title: [A man with blisters on hand and feet].
abstract: A 41-year-old man with metastases of a gastrointestinal stroma tumour was treated with an angiogenesis inhibitor. He presented with a distinct painful erythematous hyperkeratotic bullous hand-foot skin reaction. This was thought to be caused by the oral angiogenesis inhibitor and resolved after discontinuation of the therapy. This is a known adverse effect of angiogenesis inhibitors and is dose dependent.
authors.affiliation: Leids Universitair Medisch Centrum, Leiden, the Netherlands. A.J.Gelderblom@lumc.nl
authors.forename: A J Hans
authors.initials: AJ
authors.lastname: Gelderblom
authors.forename: Jasper I
authors.initials: JI
authors.lastname: van der Rhee
authors.forename: Jan
authors.initials: J
authors.lastname: Ouwerkerk
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D020533:Angiogenesis Inhibitors