title: Genetics of Coxiella burnetii: on the path of specialization.
abstract: Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide. Coxiella is classified as a select agent based on its past and potential use as a bioweapon and its threat to public health. Despite decades of research, we know relatively little regarding Coxiella?s molecular pathogenesis, and a vaccine is not widely available. This article briefly reviews the unusual genetics of C. burnetii; a pathogen that retains telltale genetic mementos collected over the course of its evolutionary path from a free-living bacterium to an obligate intracellular parasite of eukaryotic host cell phagosomes. Understanding why these genetic elements are maintained may help us better understand the biology of this fascinating pathogen.
authors.affiliation: Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA. mike.minnick@mso.umt.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Minnick
authors.forename: Rahul
authors.initials: R
authors.lastname: Raghavan
mesh_terms: D016997:Coxiella burnetii / Q000235:genetics* / Q000472:pathogenicity; D004269:DNA, Bacterial / Q000235:genetics*; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D008954:Models, Biological; D010588:Phagosomes / Q000382:microbiology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D037521:Virulence Factors
references.citation: Proc Natl Acad Sci U S A. 1981 May;78(5):3240-4
references.pmid: 6942430
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21755-60
references.pmid: 21098666
references.citation: Trends Microbiol. 1999 Apr;7(4):149-54
references.pmid: 10217829
references.citation: J Bacteriol. 2007 Sep;189(18):6572-9
references.pmid: 17644584
references.citation: Trends Genet. 2001 Aug;17(8):465-72
references.pmid: 11485819
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4430-4
references.pmid: 19246385
references.citation: J Bacteriol. 2009 Jul;191(13):4232-42
references.pmid: 19411324
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80
references.pmid: 14681412
references.citation: Mol Microbiol. 2007 Mar;63(5):1508-23
references.pmid: 17302824
references.citation: Annu Rev Microbiol. 2011;65:111-28
references.pmid: 21639786
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2873-8
references.pmid: 8610134
references.citation: Infect Immun. 2002 Dec;70(12):6741-50
references.pmid: 12438349
references.citation: Cell. 2002 Mar 8;108(5):583-6
references.pmid: 11893328
references.citation: PLoS Genet. 2010 Sep 09;6(9):e1001107
references.pmid: 20838593
references.citation: FEMS Microbiol Lett. 2010 Apr;305(2):177-83
references.pmid: 20199576
references.citation: J Bacteriol. 2005 Sep;187(18):6265-72
references.pmid: 16159758
references.citation: J Bacteriol. 2008 Sep;190(17):5934-43
references.pmid: 18606739
references.citation: MMWR Morb Mortal Wkly Rep. 2007 Mar 30;54(53):1-92
references.pmid: 17392681
references.citation: Infect Immun. 2001 Aug;69(8):4874-83
references.pmid: 11447163
references.citation: J Bacteriol. 1998 Apr;180(7):1970-2
references.pmid: 9537403
references.citation: Science. 1992 Apr 17;256(5055):377-9
references.pmid: 1566085
references.citation: Curr Genet. 1999 Dec;36(6):345-53
references.pmid: 10654088
references.citation: Nucleic Acids Res. 2002 Jan 1;30(1):56-8
references.pmid: 11752253
references.citation: Cell Microbiol. 2005 Jul;7(7):901-9
references.pmid: 15953023
references.citation: PLoS One. 2010 Dec 21;5(12):e15321
references.pmid: 21203564
references.citation: Annu Rev Microbiol. 2002;56:263-87
references.pmid: 12142479
references.citation: Infect Immun. 1991 Sep;59(9):3243-53
references.pmid: 1715326
references.citation: J Clin Microbiol. 2006 Jun;44(6):2283-7
references.pmid: 16757641
references.citation: Bull World Health Organ. 1982;60(3):389-94
references.pmid: 6982774
references.citation: J Bacteriol. 2004 Nov;186(21):7344-52
references.pmid: 15489446
references.citation: FEMS Microbiol Lett. 2010 Oct;311(1):61-9
references.pmid: 20727011
references.citation: PLoS Comput Biol. 2011 Feb;7(2):e1001082
references.pmid: 21379323
references.citation: Int J Antimicrob Agents. 2010 Oct;36(4):380-2
references.pmid: 20599360
references.citation: FEMS Microbiol Ecol. 2007 Jan;59(1):32-46
references.pmid: 17233744
references.citation: Mol Microbiol. 2005 Jul;57(2):318-25
references.pmid: 15978067
references.citation: Infect Immun. 2007 Sep;75(9):4263-71
references.pmid: 17606599
references.citation: Mol Microbiol. 2004 Jul;53(1):29-40
references.pmid: 15225301
references.citation: Trends Biochem Sci. 2006 Jan;31(1):41-51
references.pmid: 16356725
references.citation: Science. 2008 Jun 20;320(5883):1651-4
references.pmid: 18566289
references.citation: Nucleic Acids Res. 2003 Jan 1;31(1):439-41
references.pmid: 12520045
references.citation: Cell Microbiol. 2007 Apr;9(4):891-909
references.pmid: 17087732
references.citation: Mol Biol Evol. 2001 Sep;18(9):1654-67
references.pmid: 11504846
references.citation: Infect Immun. 1985 Sep;49(3):775-9
references.pmid: 4030104
references.citation: PLoS Pathog. 2011 May;7(5):e1002056
references.pmid: 21637816
references.citation: J Gen Microbiol. 1991 Feb;137(2):269-76
references.pmid: 1673152
references.citation: Curr Opin Struct Biol. 2005 Jun;15(3):324-30
references.pmid: 15922592
references.citation: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3937-41
references.pmid: 2023942
references.citation: J Proteome Res. 2007 Aug;6(8):3032-41
references.pmid: 17602512
references.citation: Neth J Med. 2010 Dec;68(12):382-7
references.pmid: 21209463
references.citation: J Bacteriol. 2010 Apr;192(8):2077-84
references.pmid: 20173000
references.citation: J Bacteriol. 2009 Oct;191(20):6193-202
references.pmid: 19666710
references.citation: Clin Microbiol Rev. 1999 Oct;12(4):518-53
references.pmid: 10515901
references.citation: Infect Immun. 2009 Feb;77(2):642-56
references.pmid: 19047403
references.citation: Front Microbiol. 2011 Jun 27;2:136
references.pmid: 21743810
references.citation: Mol Microbiol. 1996 Oct;22(1):9-19
references.pmid: 8899704
references.citation: Arch Intern Med. 1999 Jan 25;159(2):167-73
references.pmid: 9927100
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13880-5
references.pmid: 10570167
references.citation: J Bacteriol. 1994 Aug;176(15):4761-5
references.pmid: 8045909
references.citation: PLoS Genet. 2010 Sep 09;6(9):e1001115
references.pmid: 20838599
references.citation: Nat Rev Microbiol. 2006 Apr;4(4):295-305
references.pmid: 16541137
references.citation: J Bacteriol. 2009 Jun;191(12):4044-6
references.pmid: 19376857
references.citation: PLoS Genet. 2010 Jan 15;6(1):e1000808
references.pmid: 20090831
references.citation: Infect Immun. 2009 Dec;77(12):5640-50
references.pmid: 19786560
references.citation: Infect Immun. 2007 Nov;75(11):5282-9
references.pmid: 17709406
references.citation: Biol Direct. 2009 Apr 10;4:13
references.pmid: 19361336
references.citation: Mol Microbiol. 2008 Jun;68(5):1128-48
references.pmid: 18430135
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5455-60
references.pmid: 12704232
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8722-7
references.pmid: 15939879
references.citation: Mol Microbiol. 2003 Aug;49(4):965-76
references.pmid: 12890021
references.citation: Infect Immun. 2010 Aug;78(8):3465-74
references.pmid: 20515926
references.citation: J Bacteriol. 1996 Aug;178(16):5049-52
references.pmid: 8759877
references.citation: J Bacteriol. 2006 Apr;188(7):2309-24
references.pmid: 16547017
references.citation: Proteins. 2006 Nov 15;65(3):783-6
references.pmid: 16948161
references.citation: Appl Environ Microbiol. 2003 Sep;69(9):5512-8
references.pmid: 12957940
references.citation: Curr Opin Microbiol. 2003 Apr;6(2):140-5
references.pmid: 12732303
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):826-31
references.pmid: 15613486
references.citation: Mol Microbiol. 1993 Jul;9(2):273-83
references.pmid: 8412680
references.citation: Infect Immun. 1999 Nov;67(11):6026-33
references.pmid: 10531263
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18997-9001
references.pmid: 20944063
references.citation: Cell Microbiol. 2008 Jun;10(6):1209-20
references.pmid: 18363881
references.citation: Infect Immun. 1996 Mar;64(3):796-809
references.pmid: 8641784
references.citation: Curr Opin Genet Dev. 2004 Dec;14(6):627-33
references.pmid: 15531157
references.citation: Mol Plant Microbe Interact. 2001 Dec;14(12):1351-63
references.pmid: 11768529
references.citation: Genetics. 2005 Apr;169(4):1807-14
references.pmid: 15687275
references.citation: Infect Immun. 1987 May;55(5):1144-50
references.pmid: 3570458
references.citation: Protein Sci. 2004 Jun;13(6):1435-48
references.pmid: 15152081
references.citation: J Bacteriol. 1995 May;177(10):2946-9
references.pmid: 7751314
references.citation: J Bacteriol. 1981 Sep;147(3):1063-76
references.pmid: 7275931
references.citation: Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):8994-9
references.pmid: 9256423
references.citation: Emerg Infect Dis. 2005 Apr;11(4):619-21
references.pmid: 15829205
references.citation: Infect Immun. 2003 Jul;71(7):3714-23
references.pmid: 12819052
references.citation: J Bacteriol. 2009 Mar;191(5):1369-81
references.pmid: 19114492
references.citation: BMC Microbiol. 2007 Oct 18;7:91
references.pmid: 17949485
references.citation: Trends Microbiol. 2004 Mar;12(3):103-5
references.pmid: 15058276
references.citation: Emerg Infect Dis. 2005 Aug;11(8):1211-7
references.pmid: 16102309
references.citation: Curr Opin Genet Dev. 1999 Dec;9(6):664-71
references.pmid: 10607609
references.citation: Infect Immun. 2007 Jan;75(1):290-8
references.pmid: 17088354
references.citation: J Bacteriol. 1992 Sep;174(17):5540-8
references.pmid: 1324903
references.citation: Infect Immun. 2008 May;76(5):2189-201
references.pmid: 18316381
references.citation: J Bacteriol. 2011 Apr;193(7):1493-503
references.pmid: 21216993