title: Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjogren's syndrome in Taiwan.
abstract: OBJECTIVE
  Patients with primary Sjögren's syndrome (pSS) are at a higher risk of developing non-Hodgkin's lymphoma (NHL). However, little is known with regard to the risk of developing cancers other than NHL. The authors aimed in this study to compare the incidence of cancer in various sites among patients with pSS with the general population of Taiwan.
  
  
  METHODS
  The authors used National Health Insurance claims data to establish a nationwide population cohort of 7852 patients with pSS from 2000 to 2008 who did not have cancer prior to diagnosis of pSS. Incidence and standardised incidence ratios (SIRs) for cancer in various sites were calculated.
  
  
  RESULTS
  Among patients with pSS, 277 (2.9%) developed cancer. The SIR for cancer was 1.04 (95% CI 0.91 to 1.18) among patients of all ages with pSS and was 2.19 (95% CI 1.43 to 3.21) for patients aged 25-44 years. Female patients with pSS had a higher risk of NHL (SIR 7.1, 95% CI 4.3 to 10.3), multiple myeloma (SIR 6.1, 95% CI 2.0 to 14.2) and thyroid gland cancer (SIR 2.6, 95% CI 1.4 to 4.3) and a lower risk of colon cancer (SIR 0.22, 95% CI 0.05 to 0.65). In contrast, male patients with pSS were not at a higher risk of developing cancer in particular sites.
  
  
  CONCLUSIONS
  Patients with pSS, overall, did not have higher risk of cancer, and only patients aged 25-44 years were at an increased risk of cancer compared with their counterparts in the general population. Cancer screening for patients with pSS, especially female patients, should focus on NHL and multiple myeloma and thyroid gland cancer.
authors.affiliation: Department of Internal Medicine, Division of Allergy, Immunology, and Rheumatology, National Cheng-Kung University Medical College and Hospital, Tainan, Taiwan.
authors.forename: Meng-Yu
authors.initials: MY
authors.lastname: Weng
authors.forename: Yu-Tung
authors.initials: YT
authors.lastname: Huang
authors.forename: Ming-Fei
authors.initials: MF
authors.lastname: Liu
authors.forename: Tsung-Hsueh
authors.initials: TH
authors.lastname: Lu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015331:Cohort Studies; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D017678:Sex Distribution; D012859:Sjogren's Syndrome / Q000150:complications* / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology