title: Power cut: inhibiting mitochondrial translation to target leukemia.
abstract: In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.
authors.affiliation: Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Järås
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Ebert