title: Microwave-assisted synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-Amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2-methyl propanoic acid derivatives.
abstract: A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70-89%) by the microwave-assisted one-pot protocol in much shorter reaction times. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activity by high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. The present investigation showed significant antihyperlipidemic and antihyperglycemic activity for all compounds of the series when compared with the standard drug. Structure-activity relationship (SAR) for the series were developed by comparing total lipid profile data of synthesized compounds with fenofibrate as standard drug.
authors.affiliation: Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad, India. santoshmokale@rediffmail.com
authors.forename: Santosh N
authors.initials: SN
authors.lastname: Mokale
authors.forename: Rupali D
authors.initials: RD
authors.lastname: Elgire
authors.forename: Nikhil S
authors.initials: NS
authors.lastname: Sakle
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D059305:Diet, High-Fat; D015195:Drug Design; D058607:Fibric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D008872:Microwaves; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D001786:Blood Glucose; D058607:Fibric Acids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids