title: Paget disease of the breast: mammographic, US, and MR imaging findings with pathologic correlation.
abstract: Paget disease is a rare malignancy of the breast characterized by infiltration of the nipple epidermis by adenocarcinoma cells. The clinical features of Paget disease are characteristic and should increase the likelihood of the diagnosis being made. An important point is that more than 90% of cases of Paget disease are associated with an additional underlying breast malignancy. Paget disease is frequently associated with ductal carcinoma in situ (DCIS) in the underlying lactiferous ducts of the nipple-areolar complex; it may even be associated with DCIS or invasive breast cancer elsewhere in the breast, at least 2 cm from the nipple-areolar complex. Nevertheless, mammographic findings may be negative in up to 50% of cases. Magnetic resonance (MR) imaging can be useful in patients with Paget disease for evaluation of the nipple-areolar complex and identification of an additional underlying malignancy in the breast. The appropriate surgical treatment must be carefully selected and individualized on the basis of radiologic findings, especially those obtained with breast MR imaging.
authors.affiliation: Department of Radiology, Chonnam National University Medical School, 8 Hack Dong, Dong Ku, Gwangju 501-757, South Korea. nico1220@dreamwiz.com
authors.forename: Hyo Soon
authors.initials: HS
authors.lastname: Lim
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Ji Shin
authors.initials: JS
authors.lastname: Lee
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Park
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Kim
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Shin
authors.forename: Jin Gyoon
authors.initials: JG
authors.lastname: Park
authors.forename: Heoung Keun
authors.initials: HK
authors.lastname: Kang
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010144:Paget's Disease, Mammary / Q000175:diagnosis*; D013223:Statistics as Topic; D016217:Ultrasonography, Mammary / Q000379:methods*