title: Familial gastric cancer: genetics, diagnosis, and management.
abstract: This article focuses on the diagnosis and management of familial gastric cancer, particularly hereditary diffuse gastric cancer (HDGC). First, existing consensus guidelines are discussed and then the pathology and genetics of HDGC are reviewed. Second, patient management is covered, including surveillance gastroscopy, prophylactic total gastrectomy, and management of the risk of breast cancer.
authors.affiliation: Department of Surgery, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. vanessa.blair@northlanddhb.org.nz
authors.forename: Vanessa R
authors.initials: VR
authors.lastname: Blair
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics; D032921:Consensus; D004252:DNA Mutational Analysis; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods; D005773:Gastroscopy / Q000379:methods; D005820:Genetic Testing / Q000379:methods; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D010375:Pedigree; D019683:Penetrance; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D015431:Weight Loss
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins