title: [Primary autoimmune neutropenia in children].
abstract: Primary autoimmune neutropenia (AIN) is characterised by severe neutropenia and the presence of granulocyte reactive autoantibodies. The pathogenesis of the disease remains unknown and the disease is believed to be underdiagnosed. AIN occurs predominantly at the age of 6-24 months and despite severe neutropenia the symptomatology covers mainly benign infections. Serious bacterial infections might occur and some patients thus may benefit from treatment with prophylactic antibiotics or granulocyte growth factor. Spontaneous remission usually occurs within 30 months from the time of diagnosis.
authors.affiliation: Klinisk Immunologisk Afdeling, Aarhus Universitetshospital, Aalborg Sygehus, Reberbansgade, 9100 Aalborg, Denmark. k.nielsen@rn.dk
authors.forename: Kaspar René
authors.initials: KR
authors.lastname: Nielsen
authors.forename: Merete Debois
authors.initials: MD
authors.lastname: Kølbæk
authors.forename: Kirsten
authors.initials: K
authors.lastname: Høj
authors.forename: John
authors.initials: J
authors.lastname: Baech
authors.forename: Bent Windelborg
authors.initials: BW
authors.lastname: Nielsen
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D009503:Neutropenia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology