title: Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma.
abstract: Polymeric IgA (pIgA) is transcytosed by the pIgA receptor (pIgR) across mucosal epithelial cells. After transcytosis to the apical surface, the extracellular, ligand-binding portion of the pIgR is proteolytically cleaved. A missense mutation in human pIgR, A580V, is associated with IgA nephropathy and nasopharyngeal carcinoma. We report that this mutation reduces the rate of transcytosis of pIgR and pIgA, and seemingly the rate of pIgR cleavage. We propose that the defects in pIgR trafficking caused by the A580V mutation may underlie the pathogenesis of both diseases.
authors.affiliation: Department of Anatomy, University of California, San Francisco, California 94158, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Su
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Chapin
authors.forename: David M
authors.initials: DM
authors.lastname: Bryant
authors.forename: Annette M
authors.initials: AM
authors.lastname: Shewan
authors.forename: Kitty
authors.initials: K
authors.lastname: Young
authors.forename: Keith E
authors.initials: KE
authors.lastname: Mostov
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004285:Dogs; D005922:Glomerulonephritis, IGA / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000378:metabolism*; D020125:Mutation, Missense; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport / Q000235:genetics; D059748:Proteolysis; D019056:Receptors, Polymeric Immunoglobulin / Q000235:genetics / Q000378:metabolism*; D057900:Transcytosis
chemical_list: D007070:Immunoglobulin A; D009363:Neoplasm Proteins; D019056:Receptors, Polymeric Immunoglobulin
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