title: Mortality from Parkinson's disease and other causes among a workforce manufacturing paraquat: a retrospective cohort study.
abstract: Objective To assess the risk of Parkinson's disease (PD) and update information on mortality from major causes of death among a UK workforce who manufactured paraquat (PQ) between 1961 and 1995. There have been no previous studies of the incidence of PD among PQ production workers, although much epidemiological literature exists concerning the relationship between pesticides and PD, and interest has focused on PQ and its users.  Methods The cohort included all employees who had ever worked on any of the four plants at Widnes where PQ was manufactured between 1961 and 1995, and 926 male and 42 female workers were followed through 30 June 2009. Mortalities for males were compared with national and local rates, including rates for PD as a mentioned cause of death.  Results Overall, 307 workers had died by 30 June 2009. One male death was due to PD, and no other death certificate mentioned PD. At least 3.3 death certificates of male employees would have been expected to have mentioned PD (standardised mortality ratio=31; 95% CI 1 to 171). Personal monitoring results were indicative that the exposure of a PQ production worker on a daily basis was at least comparable with that of a PQ sprayer or mixer/loader. Reduced mortalities compared with local rates were found for major causes of death.  Conclusions The study provided no evidence of an increased risk of PD, or increased mortalities from other causes.
authors.affiliation: Causation Ltd, Macclesfield, UK.
authors.forename: John Andrew
authors.initials: JA
authors.lastname: Tomenson
authors.forename: Clive
authors.initials: C
authors.lastname: Campbell
references.citation: Bull World Health Organ. 1993;71(5):625-32
references.pmid: 8261566
references.citation: Br J Ind Med. 1982 Feb;39(1):76-81
references.pmid: 7066224
references.citation: Am J Epidemiol. 2007 Feb 15;165(4):364-74
references.pmid: 17116648
references.citation: J Epidemiol Community Health. 1999 Sep;53(9):587-8
references.pmid: 10562888
references.citation: Mov Disord. 2005 Mar;20(3):315-21
references.pmid: 15580618
references.citation: Neurology. 1996 May;46(5):1275-84
references.pmid: 8628466
references.citation: Scand J Work Environ Health. 1991 Jun;17(3):175-8
references.pmid: 2068555
references.citation: Mov Disord. 2006 Oct;21(10):1791-2; author reply 1792
references.pmid: 16544292
references.citation: Acta Neurol Scand. 1995 Jul;92(1):55-8
references.pmid: 7572061
references.citation: Environ Health Perspect. 2009 Jun;117(6):964-9
references.pmid: 19590691
references.citation: J Occup Environ Med. 1998 Apr;40(4):351-62
references.pmid: 9571527
references.citation: J Occup Environ Med. 2005 Oct;47(10):1059-87
references.pmid: 16217247
references.citation: Eur J Neurosci. 2003 Aug;18(3):589-600
references.pmid: 12911755
references.citation: Occup Environ Med. 2001 Sep;58(9):582-9
references.pmid: 11511745
references.citation: Am J Epidemiol. 1999 Feb 15;149(4):347-52
references.pmid: 10025477
references.citation: Int Arch Occup Environ Health. 2009 Mar;82(4):455-62
references.pmid: 18762966
references.citation: J Neurol. 2010 May;257(5):706-15
references.pmid: 19946783
references.citation: Am J Ind Med. 2010 Mar;53(3):217-23
references.pmid: 20025075
references.citation: Neurobiol Dis. 2002 Jul;10(2):119-27
references.pmid: 12127150
references.citation: Mov Disord. 1999 Nov;14(6):928-39
references.pmid: 10584666
references.citation: Neurology. 1997 Jun;48(6):1583-8
references.pmid: 9191770
references.citation: Mov Disord. 1994 Jan;9(1):69-75
references.pmid: 8139607
references.citation: Acta Neurol Scand. 2001 Jan;103(1):7-11
references.pmid: 11153892
references.citation: Am J Epidemiol. 2009 Apr 15;169(8):919-26
references.pmid: 19270050
references.citation: Environ Health Perspect. 2007 May;115(5):684-9
references.pmid: 17520053
references.citation: Environ Health Perspect. 2006 Feb;114(2):156-64
references.pmid: 16451848
references.citation: Arch Neurol. 2009 Sep;66(9):1106-13
references.pmid: 19752299
references.citation: Am J Ind Med. 1990;17(3):349-55
references.pmid: 2305814
references.citation: Cell Death Differ. 2010 Jul;17(7):1115-25
references.pmid: 20094060
references.citation: Mov Disord. 1995 Sep;10(5):678
references.pmid: 8552125
references.citation: Health Stat Q. 2006 Summer;(30):6-14
references.pmid: 16759077
references.citation: Mov Disord. 2003 Nov;18(11):1312-6
references.pmid: 14639673