title: The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB.
abstract: Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin transporter in Asperger's Disorder. Seventeen individuals with Asperger's Disorder (age=34.3 ± 11.1 years) and 17 healthy controls (age=33.0 ± 9.6 years) were scanned with [(11)C]MDL 100907. Of the 17 patients, eight (age=29.7 ± 7.0 years) were also scanned with [¹¹C]DASB, as were eight healthy controls (age=28.7 ± 7.0 years). Patients with Asperger's Disorder and healthy control subjects were matched for age, gender, and ethnicity, and all had normal intelligence. Metabolite-corrected arterial plasma inputs were collected and data analyzed by two-tissue compartment modeling. The primary outcome measure was regional binding potential BP(ND). Neither regional [¹¹C]MDL 100907 BP(ND) nor [¹¹C]DASB BP(ND) was statistically different between the Asperger's and healthy subjects. This study failed to find significant alterations in binding parameters of 5-HT(2A) receptors and serotonin transporters in adult subjects with Asperger's disorder.
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA. Electronic address: rg2290@columbia.edu.
authors.forename: Ragy R
authors.initials: RR
authors.lastname: Girgis
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Slifstein
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Departments of Psychiatry and Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: W Gordon
authors.initials: WG
authors.lastname: Frankle
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
authors.forename: Evdokia
authors.initials: E
authors.lastname: Anagnostou
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Wasserman
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Pepa
authors.affiliation: Seaver Autism Center for Research and Treatment, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kolevzon
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Anissa
authors.initials: A
authors.lastname: Abi-Dargham
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA; Department of Neurosciences, Imperial College, London, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Laruelle
authors.affiliation: Department of Psychiatry, Montefiore Medical Center, University Hospital of Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Hollander
mesh_terms: D000293:Adolescent; D000328:Adult; D020817:Asperger Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D001596:Benzylamines / Q000493:pharmacokinetics*; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D005260:Female; D005464:Fluorobenzenes / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001596:Benzylamines; D002250:Carbon Radioisotopes; D005464:Fluorobenzenes; C420885:N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine; D010880:Piperidines; D044402:Receptor, Serotonin, 5-HT2A; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; C079049:volinanserin
references.citation: J Autism Dev Disord. 2009 Jan;39(1):97-104
references.pmid: 18592367
references.citation: J Med Chem. 1991 Oct;34(10):3144-6
references.pmid: 1920365
references.citation: J Med Chem. 2000 Aug 10;43(16):3103-10
references.pmid: 10956218
references.citation: J Nucl Med. 2000 Sep;41(9):1465-77
references.pmid: 10994724
references.citation: Life Sci. 1996;58(10):PL 187-92
references.pmid: 8602111
references.citation: Synapse. 1999 May;32(2):93-109
references.pmid: 10231129
references.citation: Ann Neurol. 1997 Oct;42(4):666-9
references.pmid: 9382481
references.citation: J Nucl Med. 2006 May;47(5):815-26
references.pmid: 16644752
references.citation: Psychopharmacology (Berl). 2000 Mar;148(4):400-3
references.pmid: 10928313
references.citation: Arch Gen Psychiatry. 2010 Jan;67(1):59-68
references.pmid: 20048223
references.citation: Eur J Nucl Med. 2000 Nov;27(11):1719-22
references.pmid: 11105830
references.citation: Synapse. 1993 Apr;13(4):295-309
references.pmid: 7683143
references.citation: Arch Gen Psychiatry. 1996 Nov;53(11):993-1000
references.pmid: 8911222
references.citation: J Nucl Med. 2002 May;43(5):678-92
references.pmid: 11994534
references.citation: Arch Gen Psychiatry. 1989 Mar;46(3):213-21
references.pmid: 2919950
references.citation: J Cereb Blood Flow Metab. 2000 Feb;20(2):225-43
references.pmid: 10698059
references.citation: J Nucl Med. 1998 Jan;39(1):208-14
references.pmid: 9443763
references.citation: Am J Psychiatry. 2006 May;163(5):934-6
references.pmid: 16648340
references.citation: J Cereb Blood Flow Metab. 2001 Sep;21(9):1034-57
references.pmid: 11524609
references.citation: J Nucl Med. 2004 Apr;45(4):682-94
references.pmid: 15073266
references.citation: Neuroimage. 1997 Oct;6(3):209-17
references.pmid: 9344825
references.citation: J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9
references.pmid: 17519979
references.citation: Dev Med Child Neurol. 2008 Aug;50(8):593-7
references.pmid: 18754896