title: A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption.
abstract: BACKGROUND
  To investigate the mechanism by which strontium ranelate (SrR) inhibits the bone resorption, this study compared the effects of SrR and calcium on parathyroid hormone (PTH) and the biochemical marker of bone resorption (serum type 1 collagen cross-linked C-telopeptide, βCTX).
  
  
  METHODS
  In 10 healthy young subjects, after overnight fasting, 1000 mg of elemental calcium and 2000 mg of SrR containing 600 mg Sr²⁺ were administered consecutively with a 1 week washout period. During the control period no drug was given. Fasting blood samples were drawn at baseline and throughout the next 5-h period.
  
  
  RESULTS
  After the ingestion of either calcium or SrR, there was a significant increase in serum calcium and strontium concentrations, and a decrease in serum βCTX and intact PTH concentrations as compared to the baseline values (p<0.05). In the fasting subjects, no significant differences in the variable were found as compared to the baseline values.
  
  
  CONCLUSIONS
  The decrease in PTH and the marker of bone resorption observed after the SrR administration is comparable to the decrease observed after the calcium administration in young adults.
authors.affiliation: Institute of Rheumatology, Faculty of Medicine 1, Charles University, Prague, Czech Republic. maresova.kristyna@seznam.cz
authors.forename: Kristyna Brabnikova
authors.initials: KB
authors.lastname: Maresova
authors.forename: Tomas
authors.initials: T
authors.lastname: Franek
authors.forename: Tomas
authors.initials: T
authors.lastname: Vondracek
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Stepan
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001862:Bone Resorption / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000494:pharmacology*; D024042:Collagen Type I / Q000097:blood*; D005215:Fasting; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000097:blood / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000097:blood*; D010455:Peptides / Q000097:blood*; D012015:Reference Standards; D013876:Thiophenes / Q000097:blood / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D009942:Organometallic Compounds; D010281:Parathyroid Hormone; D010455:Peptides; D013876:Thiophenes; C052929:collagen type I trimeric cross-linked peptide; C081587:strontium ranelate; D002118:Calcium