title: [Rho proteins - the key regulators of cytoskeleton in the progression of mitosis and cytokinesis].
abstract: The Rho proteins are members of the Ras superfamily of small GTPases. They are thought to be crucial regulators of multiple signal transduction pathways that influence a wide range of cellular functions, including migration, membrane trafficking, adhesion, polarity and cell shape changes. Thanks to their ability to control the assembly and organization of the actin and microtubule cytoskeletons, Rho GTPases are known to regulate mitosis and cytokinesis progression. These proteins are required for formation and rigidity of the cortex during mitotic cell rounding, mitotic spindle formation and attachment of the spindle microtubules to the kinetochore. In addition, during cytokinesis, they are involved in promoting division plane determination, contractile ring and cleavage furrow formation and abscission. They are also known as regulators of cell cycle progression at the G1/S and G2/M transition. Thus, the signal transduction pathways in which Rho proteins participate, appear to connect dynamics of actin and microtubule cytoskeletons to cell cycle progression. We review the current state of knowledge concerning the molecular mechanisms by which Rho GTPase signaling regulates remodeling of actin and microtubule cytoskeletons in order to control cell division progression.
authors.affiliation: Katedra i Zakład Histologii i Embriologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu.
authors.forename: Anna
authors.initials: A
authors.lastname: Klimaszewska
authors.forename: Anna
authors.initials: A
authors.lastname: Stenzel
authors.forename: Jakub Marcin
authors.initials: JM
authors.lastname: Nowak
authors.forename: Alina
authors.initials: A
authors.lastname: Grzanka
mesh_terms: D048749:Cytokinesis / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020741:rho GTP-Binding Proteins