title: Association of genetic loci with blood lipids in the Chinese population.
abstract: BACKGROUND
  Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population.
  
  
  RESULTS
  We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese cohorts, comprising 2533 and 2105 individuals respectively. SNPs in APO(A1/C3/A4/A5), TIMD4-HAVCR1, DOCK7, TRIB1, ABCA1, and TOMM40-APOE showed strong associations with at least one lipids trait, and rs174546 in FADS1/2/3 showed modest association with triglyceride in the Chinese population.
  
  
  CONCLUSIONS
  We successfully replicated 7 loci associated plasma lipid concentrations in the Chinese population. Our study confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1, DOCK7, TIMD4-HAVCR1, TRIB1 and FADS1/2 in plasma lipid and lipoprotein concentrations in Chinese population.
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhang
authors.forename: Liming
authors.initials: L
authors.lastname: Tao
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Daizhan
authors.initials: D
authors.lastname: Zhou
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Kan
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Can
authors.initials: C
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D002681:China; D015331:Cohort Studies; D000090943:Delta-5 Fatty Acid Desaturase; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D008055:Lipids; C000716847:FADS1 protein, human
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