title: Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.
abstract: BACKGROUND
  There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production.
  
  
  OBJECTIVE
  To investigate the potential association of two polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL-18 gene with the risk of HBV recurrence after liver transplantation (LT) in Han Chinese patients.
  
  
  METHODS
  IL-18 promoter genotyping was performed by the snapshot technique in 125 patients with HBV-related end-stage liver disease (ESLD) receiving LT in our center from 2004 to 2008.
  
  
  RESULTS
  Among the study samples, no significant association between the IL-18 promoter polymorphisms ( 137G/C and 607C/A) or haplotypes and HBV recurrence after LT was found.
  
  
  CONCLUSIONS
  The polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL-18 gene may not play a key role in HBV recurrence after LT in Han Chinese population, and may not be suitable predictors for HBV recurrence in clinical practice.
authors.affiliation: Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xie
authors.forename: Bajin
authors.initials: B
authors.lastname: Wei
authors.forename: Shengyong
authors.initials: S
authors.lastname: Yin
authors.forename: Yufu
authors.initials: Y
authors.lastname: Ye
authors.forename: Weijia
authors.initials: W
authors.lastname: Fang
authors.forename: Shusen
authors.initials: S
authors.lastname: Zheng
references.citation: Br J Haematol. 2000 Jun;109(3):652-7
references.pmid: 10886219
references.citation: Genes Immun. 2005 May;6(3):211-6
references.pmid: 15789055
references.citation: Immunogenetics. 2006 Jun;58(5-6):471-3
references.pmid: 16738942
references.citation: J Autoimmun. 2004 Feb;22(1):73-8
references.pmid: 14709415
references.citation: Clin Genet. 2004 Mar;65(3):191-201
references.pmid: 14756669
references.citation: Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):502-8
references.pmid: 16286252
references.citation: World J Gastroenterol. 2005 Mar 21;11(11):1594-8
references.pmid: 15786533
references.citation: Immunol Today. 2000 Jul;21(7):312-5
references.pmid: 10871869
references.citation: Tissue Antigens. 2007 Aug;70(2):160-3
references.pmid: 17610422
references.citation: Transpl Infect Dis. 2011 Jun;13(3):250-8
references.pmid: 20977567
references.citation: Best Pract Res Clin Gastroenterol. 2007;21(1):175-90
references.pmid: 17223504
references.citation: N Engl J Med. 2008 Oct 2;359(14):1486-500
references.pmid: 18832247
references.citation: Gut. 2000 Feb;46(2):260-9
references.pmid: 10644323
references.citation: Liver Int. 2007 Nov;27(9):1202-8
references.pmid: 17919231
references.citation: Diabetes. 2002 Nov;51(11):3347-9
references.pmid: 12401730
references.citation: Arch Med Res. 2008 May;39(4):420-8
references.pmid: 18375254
references.citation: Chin Med J (Engl). 2007 Sep 20;120(18):1606-10
references.pmid: 17908480
references.citation: Gut. 2010 Oct;59(10):1430-45
references.pmid: 20525968
references.citation: Dig Dis Sci. 2010 Apr;55(4):1113-9
references.pmid: 19466545
references.citation: J Infect Dis. 2008 Oct 15;198(8):1159-65
references.pmid: 18781864
references.citation: Adv Immunol. 1998;70:281-312
references.pmid: 9755340
references.citation: Transl Res. 2009 Feb;153(2):91-6
references.pmid: 19138654
references.citation: J Neuroimmunol. 2001 Jan 1;112(1-2):146-52
references.pmid: 11108943
references.citation: Mediators Inflamm. 2008;2008:309721
references.pmid: 18949051
references.citation: Immunology. 2005 Jan;114(1):112-20
references.pmid: 15606801