title: Analysis of chicken anemia virus genome: evidence of intersubtype recombination.
abstract: BACKGROUND
  Chicken anemia virus (CAV) is the causative agent of chicken infectious anemia. CAV putative intergenotypic recombinants have been reported previously. This fact is based on the previous classification of CAV sequences into three genotypes. However, it is unknown whether intersubtype recombination occurs between the recently reported four CAV genotypes and five subtypes of genome sequences.
  
  
  RESULTS
  Phylogenetic analysis, together with a variety of computational recombination detection algorithms, was used to investigate CAV approximately full genomes. Statistically significant evidence of intersubtype recombination was detected in the parent-like and two putative CAV recombinant sequences. This event was shown to occur between CAV subgroup A1 and A2 sequences in the phylogenetic trees.
  
  
  CONCLUSIONS
  We revealed that intersubtype recombination in CAV genome sequences played a role in generating genetic diversity within the natural population of CAV.
authors.affiliation: Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou 225009, PR China.
authors.forename: Yassir M
authors.initials: YM
authors.lastname: Eltahir
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.forename: Wenjie
authors.initials: W
authors.lastname: Jin
authors.forename: Aijian
authors.initials: A
authors.lastname: Qin
mesh_terms: D017727:Chicken anemia virus / Q000145:classification* / Q000235:genetics*; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral
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