title: Antibacterial compounds from the mushroom Ganoderma colossum from Nigeria.
abstract: Three colossolactones (colossolactone E, colossolactone B and 23-hydroxycolossolactone E) were isolated and characterized from an n-hexane:dichloromethane (2:7) extract of Ganoderma colossum using chromatographic techniques. The antimicrobial activity of the three compounds was then tested against Gram-positive and Gram-negative bacteria. The activity was evaluated by the thin-layer chromatography agar overlay method. The results showed that colossolactone E and 23-hydroxycolossolactone E were active against Bacillus subtilis and Pseudomonas syringae. Colossolactone B was not active against the bacteria. Their structures were elucidated by spectroscopic methods. Potency of the compounds against bacteria tested supports the use of this mushroom in therapeutic medicine.
authors.affiliation: Department of Biological Sciences, Yaba College of Technology, Yaba, Lagos, Nigeria. nwannemka@yahoo.com
authors.forename: L N
authors.initials: LN
authors.lastname: Ofodile
authors.forename: N
authors.initials: N
authors.lastname: Uma
authors.forename: R J
authors.initials: RJ
authors.lastname: Grayer
authors.forename: O T
authors.initials: OT
authors.lastname: Ogundipe
authors.forename: M S J
authors.initials: MS
authors.lastname: Simmonds
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D032902:Ganoderma / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009549:Nigeria; D044224:Pseudomonas syringae / Q000187:drug effects*
chemical_list: C583736:23-hydroxycolossolactone E; D000900:Anti-Bacterial Agents; D007783:Lactones; C583737:colossolactone B; C583735:colossolactone E