title: Correlation of vitamin A nutritional status on alpha-tocopherol in the colostrum of lactating women.
abstract: The adequate supply of vitamins A and E to newborns is essential. However, factors such as maternal nutritional status and nutrient interaction may limit its bioavailability. The aim of this study was to establish nutritional status for vitamins A and E and evaluate the correlation of retinol on colostrum alpha-tocopherol in lactating women. A total of 103 lactating women were recruited at a Brazilian public maternity hospital. Fasting serum and colostrum samples were collected in the immediate post-partum. Retinol and alpha-tocopherol levels were determined by high-performance liquid chromatography and nutritional status for these vitamins was defined from specific cut-off points for serum and colostrum. Mean serum and colostrum retinol (1.49 µmol L(-1) , 2.18 µmol L(-1) ) and alpha-tocopherol (26.4 µmol L(-1) , 26.1 µmol L(-1) ) indicated satisfactory biochemical status. However, we found a prevalence of subclinical deficiency of vitamin A and vitamin E in serum (15.5% and 16%) and colostrum (50% and 60%). Lactating women with serum retinol ≥ 1.05 µmol L(-1) showed an inverse correlation between serum retinol and alpha-tocopherol concentration in the colostrum (P = 0.008, r = -0.28). This association was not observed in serum level < 1.05 µmol L(-1) . The nutritional status of lactating women for vitamins A and E was adequate, although there is a risk of subclinical deficiency. The negative correlation of serum retinol on alpha-tocopherol concentration in the colostrum must be carefully evaluated in situations of vitamin A supplementation, because alpha-tocopherol bioavailability in maternal milk may be compromised.
authors.affiliation: Postgraduate Program in Biochemistry and Molecular Biology, Federal University of Rio Grande do Norte, Natal, Brazil.
authors.forename: Larissa Queiroz
authors.initials: LQ
authors.lastname: de Lira
authors.forename: Mayara Santa Rosa
authors.initials: MS
authors.lastname: Lima
authors.forename: Jovilma Maria Soares
authors.initials: JM
authors.lastname: de Medeiros
authors.forename: Isabelle Ferreira
authors.initials: IF
authors.lastname: da Silva
authors.forename: Roberto
authors.initials: R
authors.lastname: Dimenstein
mesh_terms: D000328:Adult; D001682:Biological Availability; D001938:Brazil / Q000453:epidemiology; D002851:Chromatography, High Pressure Liquid; D003126:Colostrum / Q000737:chemistry*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000378:metabolism*; D009751:Nutritional Requirements; D009752:Nutritional Status; D014801:Vitamin A / Q000032:analysis / Q000097:blood* / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000453:epidemiology / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000453:epidemiology / Q000378:metabolism; D055815:Young Adult; D024502:alpha-Tocopherol / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D014801:Vitamin A; D024502:alpha-Tocopherol
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