title: Predictors of nonsentinel nodal involvement to aid intraoperative decision making in breast cancer patients with positive sentinel lymph nodes.
abstract: Background. Up to 60% of patients with a positive sentinel lymph node (SLN) have no additional nodal involvement and do not benefit from completion axillary lymph node dissection (ALND). We aim to identify factors predicting for non-SLN involvement and to validate the MSKCC nomogram and Tenon score in our population. Methods. Retrospective review was performed of 110 consecutive patients with positive SLNs who underwent ALND over an 8-year period. Results. Fifty patients (45%) had non-SLN involvement. Non-SLN involvement correlated positively with the number of positive SLNs (P = 0.04), macrometastasis (P = 0.01), and inversely with the total number of SLNs harvested (P = 0.03). The MSKCC nomogram and Tenon score both failed to perform as previously reported. Conclusions. The MSKCC nomogram and Tenon score have limited value in our practice. Instead, we identified three independent predictors, which are more relevant in guiding the intraoperative decision for ALND.
authors.affiliation: Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
authors.forename: Ern Yu
authors.initials: EY
authors.lastname: Tan
authors.forename: Bernard
authors.initials: B
authors.lastname: Ho
authors.forename: Juliana J C
authors.initials: JJ
authors.lastname: Chen
authors.forename: Pey Woei
authors.initials: PW
authors.lastname: Ho
authors.forename: Christine
authors.initials: C
authors.lastname: Teo
authors.forename: Arul
authors.initials: A
authors.lastname: Earnest
authors.forename: Patrick M Y
authors.initials: PM
authors.lastname: Chan
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