title: Evaluation of online miRNA resources for biomedical applications.
abstract: MicroRNAs (miRNAs) are endogenous single-stranded, 22-nt (nucleotide) RNAs which complement mRNA to initiate post-transcriptional regulation. This review presents updates and evaluations of the public domain resources available for miRNA identification and target prediction toward their utilization in the biomedical research approach. This study discusses the basic principles of miRNA computational studies based on the nature and mechanism of action of miRNAs. Furthermore, we have explored fifty-nine current online miRNA tools that can be categorized into three classes in this paper: (i) miRNA identification; (ii) miRNA target prediction; and (iii) specialized miRNA tools.
authors.affiliation: Department of Molecular and Cell Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya City 467-8601, Japan.
authors.forename: Neil H
authors.initials: NH
authors.lastname: Tan Gana
authors.forename: Ann F B
authors.initials: AF
authors.lastname: Victoriano
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D001483:Base Sequence; D019295:Computational Biology; D057225:Data Mining; D019143:Evolution, Molecular; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000502:physiology; D012333:RNA, Messenger / Q000737:chemistry; D012984:Software
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger