title: Does pain improve earlier than mood in depressed patients with painful physical symptoms treated with duloxetine?
abstract: BACKGROUND
  In depressed patients tricyclic antidepressants and selective serotonin and noradrenaline reuptake inhibitors can reduce not only depressive, but also painful physical symptoms. We investigated whether under treatment with duloxetine pain improves earlier than mood.
  
  
  METHODS
  Data were obtained within a prospective 6-month multi-centre naturalistic study in adult out-patients with depressive episodes treated with duloxetine (fl exible doses: 30-120 mg/day). Pain and mood were assessed daily by visual analogue scales. For responders (n = 622) "time to 50 % pain response" and "time to 50 % mood response" were determined by counting the earliest day between day 0 and 27, at which the patient achieved 50 % improvement.
  
  
  RESULTS
  Mean time to 50 % pain response (mean 6.3 days, SD 5.3) was significantly shorter than time to 50 % mood response (mean 7.6 days, SD 6.0, mean difference 1.3 days, SD 6.4; p < 0.0001).
  
  
  CONCLUSIONS
  In duloxetine-responders to both pain and mood, self-rated pain improved slightly earlier than self-rated mood. The short temporal dissociation between pain and mood improvement might be explained by an earlier conscious perception of pain than mood changes.
authors.affiliation: Department of Psychiatry, University of Leipzig, Leipzig, Germany. Ulrich.Hegerl@medizin.uni-leipzig.de
authors.forename: U
authors.initials: U
authors.lastname: Hegerl
authors.forename: R
authors.initials: R
authors.lastname: Mergl
authors.forename: D
authors.initials: D
authors.lastname: Quail
authors.forename: E
authors.initials: E
authors.lastname: Schneider
authors.forename: H-P
authors.initials: HP
authors.lastname: Hundemer
authors.forename: M
authors.initials: M
authors.lastname: Linden
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000928:Antidepressive Agents / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy* / Q000523:psychology*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013876:Thiophenes / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride