title: Identification and development of 2,5-disubstituted oxadiazole as potential candidate for treatment of XDR and MDR tuberculosis.
abstract: Tuberculosis, the infection on the verge of eradication once, is now a great threat to mankind. Emergence of MDR and XDR-TB synergised with HIV and other immune-compressive diseases have increased the life threatening capacities of the disease. A small molecule has been identified here, which showed potent anti-tubercular activity. The identified hit compound has also been proved active against nearly 25 clinical isolates comparable with isoniazid.
authors.affiliation: Department of Medicinal Chemistry, Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal, Maharashtra 445001, India. nddd2011@gmail.com
authors.forename: Ravi L
authors.initials: RL
authors.lastname: Bakal
authors.forename: Surendra G
authors.initials: SG
authors.lastname: Gattani
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D055808:Drug Discovery; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy*; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000995:Antitubercular Agents; D010069:Oxadiazoles