title: Inherited bleeding disorders in pregnancy.
abstract: Women with inherited bleeding disorders may face several haemostatic challenges during pregnancy and childbirth. Pregnancy in these women requires specialised and individualised care. Prenatal diagnosis is primarily considered in families affected by severe bleeding disorder such as haemophilia. Non-invasive fetal sex determination by analysis of free fetal DNA in maternal blood offers carriers of haemophilia a means of avoiding invasive testing and its associated risks in female pregnancies. With the exception of fibrinogen and factor XIII deficiencies, it is currently unclear whether women with inherited bleeding disorders are at increased risk of miscarriage or antepartum haemorrhage. However, they are at increased risk of primary and secondary postpartum haemorrhage. The fetus, if severely affected, is at risk of cranial bleeding during labour and delivery. Appropriate haemostatic cover during labour and delivery, avoidance of prolonged labour and traumatic delivery, and active management of third stage of labour can minimise the risk of bleeding complications for the mother and her fetus.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Free Hospital, Pond Street, London, UK.
authors.forename: Claudia
authors.initials: C
authors.lastname: Chi
authors.forename: Rezan A
authors.initials: RA
authors.lastname: Kadir
mesh_terms: D025861:Blood Coagulation Disorders, Inherited / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D002836:Hemophilia B / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007743:Labor, Obstetric; D011181:Postnatal Care; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011296:Prenatal Diagnosis; D014842:von Willebrand Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy