title: Protective potential of MMR vaccine against complete Freund's adjuvant-induced inflammation in rats.
abstract: The aim of the present study was to investigate the effect of MMR vaccine on inflammation which was induced by complete Freund's adjuvant (CFA) in male Sprague-Dawley rats. Rats were randomly divided into the control, CFA, MMR and CFA + MMR groups. Inflammatory symptoms such as paw oedema was measured in CFA-injected rats' paw. Body weight changes and alterations in some haematological parameters and oxidative stress markers following CFA injection were checked. In CFA-inflammed rats, there was a significant increase in rat paw thickness and decrease in body weight increment. MMR exhibited a significant anti-inflammatory effect as manifested by reduction in paw thickness and normal gain in body weight when administered 1 week prior to induction of inflammation. The altered haematological parameters (TLC) and oxidative stress markers (MDA, GSH, SOD) in the inflammed rats were significantly brought back to near normal by MMR treatment. In conclusion, MMR vaccine showed a reduction in rat paw thickness and it could significantly normalize the haematological and biochemical abnormalities in CFA-induced inflammatory pain model in rats. Our data suggested that MMR could be a potential protective agent against certain types of inflammatory pain. Further histopathological and radiological studies are required to confirm the possibility of developing novel therapeutic vaccines against some forms of arthritis.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
authors.forename: Rehab S
authors.initials: RS
authors.lastname: Abd El-Rahman
authors.forename: Ghada M
authors.initials: GM
authors.lastname: Suddek
authors.forename: Nariman M
authors.initials: NM
authors.lastname: Gameil
authors.forename: Hassan A
authors.initials: HA
authors.lastname: El-Kashef
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001168:Arthritis / Q000188:drug therapy / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004487:Edema / Q000188:drug therapy* / Q000378:metabolism; D005620:Freund's Adjuvant / Q000633:toxicity*; D005978:Glutathione / Q000097:blood; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D022542:Measles-Mumps-Rubella Vaccine / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D022542:Measles-Mumps-Rubella Vaccine; D008315:Malondialdehyde; D005620:Freund's Adjuvant; D013482:Superoxide Dismutase; D005978:Glutathione
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