title: Association study on IL4, IL13 and IL4RA polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.
abstract: BACKGROUND
  The IL4, IL13, and IL4 receptor α chain (IL4RA) genes are candidate genes for atopic diseases. We hypothesized that the polymorphisms in these genes are associated with persistent allergic rhinitis (PER).
  
  
  OBJECTIVE
  To investigate the association of the potential functional polymorphisms in IL4, IL13, and IL4RA with PER induced by house dust mites in a Chinese population.
  
  
  METHODS
  Using the TaqMan method, we genotyped six single nucleotide polymorphisms (SNPs) including C-590T in IL4, C-1055T and Arg130Gln in IL13, and Ile50Val, Ser478Pro and Gln551Arg in IL4RA, in a case-control study of 265 patients with PER and 275 healthy controls.
  
  
  RESULTS
  We found that the CT/CC genotypes in IL4 C-590T were associated with a significantly decreased risk of mite-sensitized PER [adjusted odds ratio (OR)  = 0.64, 95% confidence interval (CI) 0.45-0.92], compared to the TT genotype. Furthermore, PER patients with CT/CC genotypes had significantly lower serum levels of total IgE than those with TT genotype (P = 0.001). However, there was no significant association of the IL13 and IL4RA polymorphisms with mite-sensitized PER (P>0.05).
  
  
  CONCLUSIONS
  Our results suggest that the C-590T polymorphism in IL4 may contribute to the susceptibility to mite-sensitized PER in a Chinese population.
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Lu
authors.forename: Ruo-Xi
authors.initials: RX
authors.lastname: Chen
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Wang
authors.forename: Xin-Jie
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Yin
authors.forename: Zheng-Dong
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000818:Animals; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D018793:Interleukin-13 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008925:Mites / Q000276:immunology*; D011110:Polymorphism, Genetic; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012220:Rhinitis / Q000235:genetics*
chemical_list: C508598:IL4 protein, human; D018793:Interleukin-13; D019948:Receptors, Interleukin-4; D015847:Interleukin-4
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