title: Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series.
abstract: OBJECTIVE
  To evaluate survival, locoregional control and toxicity in a series of 56 mesothelioma patients treated from May 2005 to May 2010 with post-operative radiotherapy after extrapleural pneumonectomy (EPP) in three Italian Institutions (Brescia, Florence, and Modena).
  
  
  METHODS
  Fifty-six patients treated with adjuvant radiotherapy (RT) after EPP were analyzed. Four patients were treated with 3DCRT, 50 with IMRT and two with helical tomotherapy. Forty-five to 50 Gy in 25 fractions were given to the affected hemithorax and to ipsilateral mediastinum, with a simultaneous integrated boost to the sites of microscopically involved margins up to 60 Gy in 20/56 cases.
  
  
  RESULTS
  Three year locoregional control (LRC), distant metastasis free (DMF), disease free (DF), disease specific (DSS) and overall survival (OS) rates are 90%, 66%, 57%, 62%, and 60%, respectively.
  
  
  CONCLUSIONS
  Postoperative RT with modern techniques is an effective method to obtain excellent local control and cure rates in mesothelioma patients submitted to EPP.
authors.affiliation: Department of Radiation Oncology, Brescia University, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Tonoli
authors.forename: Paola
authors.initials: P
authors.lastname: Vitali
authors.forename: Vieri
authors.initials: V
authors.lastname: Scotti
authors.forename: Filippo
authors.initials: F
authors.lastname: Bertoni
authors.forename: Luigi
authors.initials: L
authors.lastname: Spiazzi
authors.forename: Barbara
authors.initials: B
authors.lastname: Ghedi
authors.forename: Fabrizio Banci
authors.initials: FB
authors.lastname: Buonamici
authors.forename: Livia
authors.initials: L
authors.lastname: Marrazzo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Guidi
authors.forename: Icro
authors.initials: I
authors.lastname: Meattini
authors.forename: Paolo
authors.initials: P
authors.lastname: Bastiani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Amichetti
authors.forename: Marco
authors.initials: M
authors.lastname: Schwarz
authors.forename: Stefano Maria
authors.initials: SM
authors.lastname: Magrini
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000528:radiation effects; D006801:Humans; D007558:Italy; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008297:Male; D008654:Mesothelioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010997:Pleural Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011013:Pneumonectomy / Q000379:methods*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016896:Treatment Outcome