title: A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies.
abstract: This report concerns a 12-year-old male with intractable seizures over a long period. The case fulfilled the diagnostic criteria for nonherpetic acute limbic encephalitis. He had frequent convulsions starting with a partial seizure at the left angle of the mouth and progressing to secondary generalized seizures. He was treated with several anticonvulsants, combined with methylprednisolone and γ-globulin under mechanical ventilation. However, his convulsions reappeared after tapering of the barbiturate. His magnetic resonance imaging showed a high intensity area in the hippocampus by FLAIR and diffusion. After five months he recovered without serious sequelae. Virological studies, including for herpes simplex virus, were all negative. He was transiently positive for antiglutamate receptor antibodies in cerebrospinal fluid and serum.
authors.affiliation: Department of Pediatrics, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Chiako
authors.initials: C
authors.lastname: Ishii
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ioi
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ogihara
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
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