title: High resolution colonoscopy in a bowel cancer screening program improves polyp detection.
abstract: OBJECTIVE
  To compare high resolution colonoscopy (Olympus Lucera) with a megapixel high resolution system (Pentax HiLine) as an in-service evaluation.
  
  
  METHODS
  Polyp detection rates and measures of performance were collected for 269 colonoscopy procedures. Five colonoscopists conducted the study over a three month period, as part of the United Kingdom bowel cancer screening program.
  
  
  RESULTS
  There were no differences in procedure duration (χ² P = 0.98), caecal intubation rates (χ² P = 0.67), or depth of sedation (χ² P = 0.64). Mild discomfort was more common in the Pentax group (χ² P = 0.036). Adenoma detection rate was significantly higher in the Pentax group (χ² test for trend P = 0.01). Most of the extra polyps detected were flat or sessile adenomas.
  
  
  CONCLUSIONS
  Megapixel definition colonoscopes improve adenoma detection without compromising other measures of endoscope performance. Increased polyp detection rates may improve future outcomes in bowel cancer screening programs.
authors.affiliation: Department of Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW12BU, United Kingdom.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Banks
authors.forename: Rehan
authors.initials: R
authors.lastname: Haidry
authors.forename: M Adil
authors.initials: MA
authors.lastname: Butt
authors.forename: Lisa
authors.initials: L
authors.lastname: Whitley
authors.forename: Judith
authors.initials: J
authors.lastname: Stein
authors.forename: Louise
authors.initials: L
authors.lastname: Langmead
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Bloom
authors.forename: Austin
authors.initials: A
authors.lastname: O'Bichere
authors.forename: Sara
authors.initials: S
authors.lastname: McCartney
authors.forename: Kalpesh
authors.initials: K
authors.lastname: Basherdas
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez-Justo
authors.forename: Laurence B
authors.initials: LB
authors.lastname: Lovat
mesh_terms: D003111:Colonic Polyps / Q000175:diagnosis* / Q000601:surgery; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006113:United Kingdom
references.citation: Gut. 2008 Jan;57(1):65-70
references.pmid: 17682000
references.citation: Clin Gastroenterol Hepatol. 2009 Mar;7(3):288-95
references.pmid: 19168154
references.citation: Gastroenterology. 1997 Jan;112(1):24-8
references.pmid: 8978338
references.citation: Gastrointest Endosc. 2009 Mar;69(3 Pt 1):399-407
references.pmid: 19231483
references.citation: Am J Gastroenterol. 2002 Jun;97(6):1296-308
references.pmid: 12094842
references.citation: Lancet Oncol. 2009 Dec;10(12):1171-8
references.pmid: 19910250
references.citation: Gastrointest Endosc. 2007 May;65(6):757-66
references.pmid: 17466195
references.citation: Gastrointest Endosc. 2009 Mar;69(3 Pt 2):716-22
references.pmid: 19251016
references.citation: World J Gastroenterol. 2010 Mar 7;16(9):1043-9
references.pmid: 20205272
references.citation: Am J Gastroenterol. 2010 Dec;105(12):2588-96
references.pmid: 20877348
references.citation: Dig Dis Sci. 2011 Aug;56(8):2384-8
references.pmid: 21318587
references.citation: Endoscopy. 2011 Aug;43(8):683-91
references.pmid: 21623556
references.citation: Lancet. 2000 Apr 8;355(9211):1211-4
references.pmid: 10770302
references.citation: Gastrointest Endosc. 2005 Mar;61(3):385-91
references.pmid: 15758908
references.citation: Clin Gastroenterol Hepatol. 2008 Oct;6(10):1091-8
references.pmid: 18639495
references.citation: Gastrointest Endosc. 2008 Feb;67(2):280-6
references.pmid: 18155210
references.citation: Gastrointest Endosc. 2006 Apr;63(4 Suppl):S16-28
references.pmid: 16564908
references.citation: Am J Gastroenterol. 2009 Mar;104(3):739-50
references.pmid: 19240699
references.citation: Endoscopy. 2003 Jun;35(6):506-10
references.pmid: 12783349
references.citation: CA Cancer J Clin. 2006 May-Jun;56(3):143-59; quiz 184-5
references.pmid: 16737947
references.citation: N Engl J Med. 2006 Dec 14;355(24):2533-41
references.pmid: 17167136
references.citation: N Engl J Med. 2010 May 13;362(19):1795-803
references.pmid: 20463339
references.citation: Gastroenterology. 2007 Jan;132(1):96-102
references.pmid: 17241863
references.citation: Gastroenterology. 2007 Jul;133(1):42-7
references.pmid: 17631129