title: No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.
abstract: The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts.
authors.affiliation: The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA. smb2174@columbia.edu
authors.forename: Sandra
authors.initials: S
authors.lastname: Barral
authors.forename: Israel
authors.initials: I
authors.lastname: Fernández-Cadenas
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Bis
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
authors.forename: Arfan M
authors.initials: AM
authors.lastname: Ikram
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.forename: Helena
authors.initials: H
authors.lastname: Schmidt
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D020520:Brain Infarction / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D017691:Caribbean Region / Q000208:ethnology; D016022:Case-Control Studies; D015331:Cohort Studies; D056726:Genetic Association Studies; D006239:Haplotypes / Q000235:genetics; D006630:Hispanic or Latino / Q000208:ethnology / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human
references.citation: Arch Neurol. 2008 Aug;65(8):1053-61
references.pmid: 18695055
references.citation: Arch Neurol. 2009 Jul;66(7):834-40
references.pmid: 19433651
references.citation: Eur J Hum Genet. 2009 Nov;17(11):1448-53
references.pmid: 19417766
references.citation: Stat Med. 2002 Jan 15;21(1):35-50
references.pmid: 11782049
references.citation: Bioinformatics. 2003 Jan;19(1):149-50
references.pmid: 12499305
references.citation: Stroke. 2010 Feb;41(2):210-7
references.pmid: 20044523
references.citation: Nat Genet. 2004 Mar;36(3):233-9
references.pmid: 14770184
references.citation: Stroke. 2006 Aug;37(8):2007-11
references.pmid: 16778124