title: Metastasis of a ductal breast carcinoma to the buccal mucosa of the mandible with tooth involvement.
abstract: BACKGROUND
  We present a metastatic tumour from the breast to the gingiva, with the rare finding of tooth invasion. Metastatic tumours to the oral region are uncommon. The breast is the most common primary site for metastatic tumours to the jawbones in women, with the mandible being most often affected.
  
  
  METHODS
  We report the case of a 52-year-old Caucasian woman who presented with a swelling of the buccal mucosa in the molar region of the left mandible. Biopsy revealed a metastatic lesion, with involvement of the two adjacent molars. Immunohistochemical analysis ruled out other malignancies and confirmed the diagnosis of a ductal breast carcinoma origin.
  
  
  CONCLUSIONS
  Management in such cases should be in the context of the treatment of a metastatic disease that could prolong survival and improve quality of life, but is not curative. Tooth invasion has been described since 1910 for different primary malignancies with distant metastases to the oral cavity. This report seems to describe the second case in the literature of a metastatic breast carcinoma to the mandible with tooth invasion. Management in such cases should be in the context of the treatment of a metastatic disease that could prolong survival and improve quality of life, but is not curative.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Theagenion Cancer Hospital of Thessaloniki, Davaki 18, 572 00 Lagadas, Thessaloniki, Greece. nikoskech@gmail.com
authors.forename: Nikos
authors.initials: N
authors.lastname: Kechagias
authors.forename: Aris
authors.initials: A
authors.lastname: Ntomouchtsis
authors.forename: Anna
authors.initials: A
authors.lastname: Patrikidou
authors.forename: Barbara
authors.initials: B
authors.lastname: Christoforidou
authors.forename: Charalambos
authors.initials: C
authors.lastname: Andreadis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vahtsevanos
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000556:secondary*; D059248:Chemoradiotherapy; D005260:Female; D005887:Gingival Neoplasms / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008334:Mandible / Q000473:pathology*; D008875:Middle Aged; D008963:Molar / Q000473:pathology*; D009361:Neoplasm Invasiveness; D011879:Radiotherapy Dosage
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