title: Testosterone and sex hormone-binding globulin have significant association with metabolic syndrome in Taiwanese men.
abstract: OBJECTIVE
  To investigate the relationship between sex hormones and metabolic syndrome (MS) in an Asian population.
  
  
  METHODS
  A cross-sectional study was conducted in 237 men aged 20-88 years (mean age 52 years). Serum lipids, glucose, insulin, total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), and dehydroepiandosterone sulfate (DHEA-S) were measured along with body height, weight, waist circumference, and blood pressure. Free testosterone (FT) and bioavailable testosterone (BT) were calculated. Correlations were determined using univariate and multivariate regression analyses.
  
  
  RESULTS
  Men with MS had lower levels of TT, BT, FT, SHBG and DHEA-S than men without MS. Multivariate analysis, after adjusting for age and smoking status, indicated that TT (OR: 0.909, 95% CI: 0.836-0.988, p = 0.003) and SHBG (OR: 0.948, 95% CI: 0.913-0.985, p = 0.006) were significantly associated with MS (R(2) = 0.314). TT was associated with waist circumference (p = 0.008) and abnormal triglycerides level (p = 0.006); SHBG was associated with blood pressure (p = 0.003), blood glucose (p = 0.043) and abnormal triglycerides (p = 0.048). A significant trend was observed between decreasing levels of TT, BT, FT, and SHBG and increasing numbers of MS components.
  
  
  CONCLUSIONS
  Results show that serum testosterone and SHBG levels inversely correlate with MS in an Asian population applying the Asian MS definition.
authors.affiliation: Division of Urology, Department of Surgery, Cardinal Tien Hospital, Taipei, Taiwan.
authors.forename: Chun-Hou
authors.initials: CH
authors.lastname: Liao
authors.forename: Chao-Yuan
authors.initials: CY
authors.lastname: Huang
authors.forename: Hung-Yuan
authors.initials: HY
authors.lastname: Li
authors.forename: Hong-Jeng
authors.initials: HJ
authors.lastname: Yu
authors.forename: Han-Sun
authors.initials: HS
authors.lastname: Chiang
authors.forename: Chih-Kuang
authors.initials: CK
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013624:Taiwan / Q000453:epidemiology; D013739:Testosterone / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate