title: Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement.
abstract: Prothrombin fragment 1+2 is excreted in urine (uF1+2) as a result of in vivo thrombin generation and can be a marker of coagulation status after an operative procedure. This study compared uF1+2 levels in patients with symptomatic and non-symptomatic venous thromboembolism (VTE) after total knee replacement (TKR) and in event-free sex- and age-matched controls. Significantly higher median uF1+2 levels were seen in the VTE patients on days 1, 3, and the day of venography (mostly day 7) after TKR compared with controls. The uF1+2 levels tended to be high in some patients with symptomatic VTE; however, the discriminatory efficacy of the test could not be evaluated. In conclusion, this study showed that patients with VTE tend to have significantly higher uF1+2 levels compared with patients without events between days 1 and 7 after TKR surgery. Measurement of uF1+2 could provide a simple, non-invasive clinical test to identify patients at risk of VTE.
authors.affiliation: Department of Orthopaedics, Århus University Hospital, Nørrebrogade 44, 8000 Århus C, Denmark.
authors.forename: Lars C
authors.initials: LC
authors.lastname: Borris
authors.forename: Morten
authors.initials: M
authors.lastname: Breindahl
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lassen
authors.forename: Akos F
authors.initials: AF
authors.lastname: Pap
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