title: Diagnostic accuracy of ¹⁸F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis.
abstract: OBJECTIVE
  To systematically review and meta-analyse literature data on the diagnostic performance of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) in patients with Ewing sarcoma family tumours (ESFT).
  
  
  METHODS
  PubMed/MEDLINE, Embase and Scopus databases were searched for articles that evaluated FDG-PET and PET/CT in patients with ESFT from inception to 31 May 2011. Studies that fulfilled the three following criteria were included in the systematic review: FDG-PET or PET/CT performed in patients with ESFT; articles about the diagnostic accuracy of FDG-PET and PET/CT; sample size of at least 10 patients with ESFT were included. Studies in which there were sufficient data to reassess sensitivity and specificity of FDG-PET or PET/CT in ESFT were included in the meta-analysis, excluding duplicate publications. Finally, pooled sensitivity, pooled specificity and area under the receiver operating characteristic (ROC) curve of FDG-PET or PET/CT in ESFT were calculated.
  
  
  RESULTS
  We found 13 studies comprising a total of 342 patients with ESFT. The main findings of the studies included are presented. The meta-analysis of five selected studies provided these results about FDG-PET and PET/CT in ESFT: pooled sensitivity: 96% (95% confidence interval [CI] 91-99%); pooled specificity: 92% (95% CI 87-96%); area under the ROC curve: 0.97.
  
  
  CONCLUSIONS
  With regard to the staging and restaging of patients with ESFT, the sensitivity, specificity and accuracy of FDG-PET and PET/CT are high; the combination of FDG-PET or PET/CT with conventional imaging is a valuable tool for the staging and restaging of ESFT and has a relevant impact on the treatment strategy plan.
authors.affiliation: Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Treglia
authors.forename: Marco
authors.initials: M
authors.lastname: Salsano
authors.forename: Antonella
authors.initials: A
authors.lastname: Stefanelli
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Mattoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giordano
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bonomo
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D015995:Prevalence; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000453:epidemiology*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique / Q000706:statistics & numerical data; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
references.citation: Ann Oncol. 2002 Jan;13(1):157-60
references.pmid: 11863097
references.citation: J Clin Oncol. 2007 Dec 1;25(34):5435-41
references.pmid: 18048826
references.citation: Eur Radiol. 2010 Dec;20(12):2959-72
references.pmid: 20577880
references.citation: Nucl Med Commun. 2006 Jan;27(1):17-24
references.pmid: 16340719
references.citation: Clin Orthop Relat Res. 2006 Sep;450:101-4
references.pmid: 16906103
references.citation: Curr Opin Oncol. 2008 Jul;20(4):412-8
references.pmid: 18525337
references.citation: Nuklearmedizin. 2010;49(5):183-6
references.pmid: 20617278
references.citation: J Nucl Med. 2007 Dec;48(12):1932-9
references.pmid: 18006618
references.citation: AJR Am J Roentgenol. 2001 Jul;177(1):229-36
references.pmid: 11418435
references.citation: AJR Am J Roentgenol. 2005 Apr;184(4):1293-304
references.pmid: 15788613
references.citation: Pediatr Blood Cancer. 2010 Feb;54(2):222-7
references.pmid: 19890901
references.citation: Radiographics. 2009 Sep-Oct;29(5):1487-500
references.pmid: 19755607
references.citation: Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):1944-51
references.pmid: 19593561
references.citation: BMC Med Res Methodol. 2006 Jul 12;6:31
references.pmid: 16836745
references.citation: Radiology. 2007 Dec;245(3):839-47
references.pmid: 18024454
references.citation: Eur J Nucl Med. 2000 Sep;27(9):1305-11
references.pmid: 11007511
references.citation: Ann Oncol. 2001 Apr;12(4):479-86
references.pmid: 11398879