title: Tail-anchored membrane protein insertion into the endoplasmic reticulum.
abstract: Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly conserved parallel pathways. The well-studied co-translational pathway uses signal recognition particle (SRP) and its receptor for targeting and the SEC61 translocon for membrane integration. A recently discovered post-translational pathway uses an entirely different set of factors involving transmembrane domain (TMD)-selective cytosolic chaperones and an accompanying receptor at the ER. Elucidation of the structural and mechanistic basis of this post-translational membrane protein insertion pathway highlights general principles shared between the two pathways and key distinctions unique to each.
authors.affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. rhegde@mrc-lmb.cam.ac.uk
authors.forename: Ramanujan S
authors.initials: RS
authors.lastname: Hegde
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Keenan
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D008565:Membrane Proteins
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