title: XCL1 and XCR1 in the immune system.
abstract: XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells. This review summarizes the expression and function of XCL1 and XCR1 in the immune system.
authors.affiliation: Key Laboratory of Molecular Biology for Infectious Disease, People's Republic of China Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Takahama
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019744:Chemokines, C / Q000235:genetics / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D019707:Receptors, Chemokine / Q000276:immunology*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000276:immunology*; D017634:Self Tolerance; D013154:Spleen / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D019744:Chemokines, C; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; C551408:XC chemokine receptor 1, mouse; C092390:XCL1 protein, human; C091671:XCR1 protein, human; C486249:Xcl1 protein, mouse