title: MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines.
abstract: General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.
authors.affiliation: Department of Chemistry, Vanderbilt University and Medical Center, Nashville, TN 37232, USA.
authors.forename: Leslie N
authors.initials: LN
authors.lastname: Aldrich
authors.forename: Evan P
authors.initials: EP
authors.lastname: Lebois
authors.forename: L Michelle
authors.initials: LM
authors.lastname: Lewis
authors.forename: Natalia T
authors.initials: NT
authors.lastname: Nalywajko
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Niswender
authors.forename: C David
authors.initials: CD
authors.lastname: Weaver
authors.forename: P Jeffrey
authors.initials: PJ
authors.lastname: Conn
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
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