title: Oral low-dose chemotherapy: successful treatment of an alveolar rhabdomyosarcoma during pregnancy.
abstract: We report for the first time the impact of neoadjuvant oral low-dose chemotherapy consisting of oral trofosfamide, idarubicin, and etoposide (O-TIE) in the case of alveolar rhabdomyosarcoma (RMS) in the lower jaw of an 18-year-old woman at 27 weeks of gestation, without fetal complications and a highly efficient anti-tumor response. Our study suggests the possible application of O-TIE treatment in a neoadjuvant setting during pregnancy and recommends a schedule that can be considered for the treatment of patients with high-risk sarcomas who cannot be treated with intensive chemotherapy for various reasons.
authors.affiliation: Clinic of Pediatric Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Meinolf
authors.initials: M
authors.lastname: Siepermann
authors.forename: Ewa
authors.initials: E
authors.lastname: Koscielniak
authors.forename: Tobias
authors.initials: T
authors.lastname: Dantonello
authors.forename: Dirk
authors.initials: D
authors.lastname: Klee
authors.forename: Joachim
authors.initials: J
authors.lastname: Boos
authors.forename: Barbara
authors.initials: B
authors.lastname: Krefeld
authors.forename: Arndt
authors.initials: A
authors.lastname: Borkhardt
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoehn
authors.forename: Alexzander
authors.initials: A
authors.lastname: Asea
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Wessalowski
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011379:Prognosis; D018232:Rhabdomyosarcoma, Alveolar / Q000188:drug therapy*
chemical_list: D005047:Etoposide; D003520:Cyclophosphamide; C003726:trofosfamide; D015255:Idarubicin
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