title: Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction.
abstract: An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
authors.forename: Karen Ka-Yan
authors.initials: KK
authors.lastname: Kung
authors.forename: Gai-Li
authors.initials: GL
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Zou
authors.forename: Hiu-Chi
authors.initials: HC
authors.lastname: Chong
authors.forename: Yun-Chung
authors.initials: YC
authors.lastname: Leung
authors.forename: Ka-Hing
authors.initials: KH
authors.lastname: Wong
authors.forename: Vanessa Kar-Yan
authors.initials: VK
authors.lastname: Lo
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Man-Kin
authors.initials: MK
authors.lastname: Wong
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D009844:Oligosaccharides; D006046:Gold