title: Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads.
abstract: Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
authors.forename: Nadja C
authors.initials: NC
authors.lastname: Bigall
authors.forename: Alberto
authors.initials: A
authors.lastname: Curcio
authors.forename: Manuel Pernia
authors.initials: MP
authors.lastname: Leal
authors.forename: Andrea
authors.initials: A
authors.lastname: Falqui
authors.forename: Domenico
authors.initials: D
authors.lastname: Palumberi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Corato
authors.forename: Ennio
authors.initials: E
authors.lastname: Albanesi
authors.forename: Roberto
authors.initials: R
authors.lastname: Cingolani
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
mesh_terms: D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000494:pharmacology; D012542:Scattering, Radiation
chemical_list: D000838:Anions; D002412:Cations; D004337:Drug Carriers; D034741:RNA, Small Interfering; D006046:Gold