title: Contact lens-related dry eye and ocular surface changes with mapping technique in long-term soft silicone hydrogel contact lens wearers.
abstract: OBJECTIVE
  To evaluate ocular surface changes in long-term silicone hydrogel contact lens wearers.
  
  
  METHODS
  Thirty patients were included in this study. Twenty patients (40 eyes) using contact lenses constituted group 1 and 10 (20 eyes) volunteers constituted group 2. The duration of average contact lens usage was 7.74 ± 3.3 years. Ocular surface was evaluated by surface staining, tear film break-up time (TBUT), Schirmer I test, and conjunctival impression cytology with color-coded mapping technique and by the Ocular Surface Disease Index (OSDI).
  
  
  RESULTS
  The mean break-up time was lower and staining scores were higher in group 1 (p<0.001) but Schirmer values were not significantly different from group 2 (p>0.05). The mean OSDI score was 34.59 ± 11.93 to 19.28 ± 6.7 in group 1 and 2. Increased metaplastic predominant changes of grade II and III were observed in the interpalpebral and perilimbal areas in group 1. Significant correlations were observed in TBUT, cornea staining, and grade II to grade III metaplasia ratios between duration of the lens usage and contact lens wear time in a day.
  
  
  CONCLUSIONS
  Silicone hydrogel lenses produce significant changes on tear film and impression cytology of the ocular surface in long-term use.
authors.affiliation: Ophthalmology Clinic, Fatih Sultan Mehmet Education and Training Hospital, Istanbul - Turkey.
authors.forename: Tomris
authors.initials: T
authors.lastname: Sengor
authors.forename: Sevda
authors.initials: S
authors.lastname: Aydin Kurna
authors.forename: Nurver
authors.initials: N
authors.lastname: Ozbay
authors.forename: Semahat
authors.initials: S
authors.lastname: Ertek
authors.forename: Suat
authors.initials: S
authors.lastname: Aki
authors.forename: Ahmet
authors.initials: A
authors.lastname: Altun
mesh_terms: D000328:Adult; D004396:Coloring Agents; D003229:Conjunctival Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000009:adverse effects*; D008086:Lissamine Green Dyes; D008297:Male; D011092:Polyethylene Glycols; D012828:Silicones; D011795:Surveys and Questionnaires; D013666:Tears / Q000502:physiology
chemical_list: D004396:Coloring Agents; D008086:Lissamine Green Dyes; D012828:Silicones; C095420:silicone polyethylene glycol copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols