title: Estimation of sample size and testing power (part 2).
abstract: This article introduces definitions of three special tests, namely, non-inferiority test (to verify that the efficacy of the experimental drug is clinically not inferior to that of the positive control drug), equivalence test (to verify that the efficacy of the experimental drug is equivalent to that of the control drug) and superiority test (to verify that the efficacy of the experimental drug is superior to that of the control drug), and methods of sample size estimation under the three different conditions. By specific examples, the article introduces formulas of sample size estimation for the three special tests, and their SAS realization in detail.
authors.affiliation: Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China. lphu812@sina.com
authors.forename: Liang-ping
authors.initials: LP
authors.lastname: Hu
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Bao
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Tao
authors.forename: Shi-guo
authors.initials: SG
authors.lastname: Zhou
authors.forename: Xue
authors.initials: X
authors.lastname: Guan
mesh_terms: D003627:Data Interpretation, Statistical; D015507:Drugs, Investigational; D012107:Research Design; D018401:Sample Size
chemical_list: D015507:Drugs, Investigational