title: The Philadelphia Brief Assessment of Cognition (PBAC): a validated screening measure for dementia.
abstract: The Philadelphia Brief Assessment of the Cognition (PBAC) is a brief dementia-screening instrument. The PBAC assesses five cognitive domains: working memory/executive control; lexical retrieval/language; visuospatial/visuoconstructional operations; verbal/visual episodic memory; and behavior/social comportment. A revised version of the PBAC was administered to 198 participants including patients with Alzheimer's disease (AD) (n=46) and four groups of patients with frontotemporal dementia (FTD) syndromes: behavioral-variant FTD (bvFTD; n=65), semantic-variant primary progressive aphasia (PPA) (svPPA; n=22), non-fluent/agrammatic-variant PPA (nfaPPA; n=23), and corticobasal syndrome (CBS; n=42), and a group of normal controls (n=15). The total PBAC score was highly correlated with the MMSE. The criterion validity of the PBAC was assessed relative to standard neuropsychological test performance. Using standard neuropsychological test performance as a criterion, the total PBAC score accurately identified the presence and severity of dementia. Intra-class correlations between PBAC subscales and standard neuropsychological tests were highly significant. PBAC subscales demonstrated good clinical utility in distinguishing AD and FTD subtypes using receiver operating characteristic analysis and standard diagnostic performance statistics to determine optimal subscale cut scores. The PBAC is a valid tool and able to assesses differential patterns neuropsychological/behavioral impairment in a broad range of neurodegenerative conditions.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA. dlibon@drexelmed.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Libon
authors.forename: Katya
authors.initials: K
authors.lastname: Rascovsky
authors.forename: Rachel G
authors.initials: RG
authors.lastname: Gross
authors.forename: Matthew T
authors.initials: MT
authors.lastname: White
authors.forename: Sharon X
authors.initials: SX
authors.lastname: Xie
authors.forename: Michael
authors.initials: M
authors.lastname: Dreyfuss
authors.forename: Ashley
authors.initials: A
authors.lastname: Boller
authors.forename: Lauren
authors.initials: L
authors.lastname: Massimo
authors.forename: Peachie
authors.initials: P
authors.lastname: Moore
authors.forename: Jessica
authors.initials: J
authors.lastname: Kitain
authors.forename: H Branch
authors.initials: HB
authors.lastname: Coslett
authors.forename: Anjan
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Murray
authors.initials: M
authors.lastname: Grossman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000209:etiology*; D003704:Dementia / Q000150:complications* / Q000175:diagnosis*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008570:Memory, Short-Term / Q000502:physiology; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012919:Social Behavior; D013028:Space Perception; D014706:Verbal Learning
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