title: Biological potential of sixteen legumes in China.
abstract: Phenolic acids have been identified in a variety of legumes including lima bean, broad bean, common bean, pea, jack bean, goa bean, adzuki bean, hyacinth bean, chicking vetch, garbanzo bean, dral, cow bean, rice bean, mung bean and soybean. The present study was carried out with the following aims: (1) to identify and quantify the individual phenolic acid and determine the total phenolic content (TPC); (2) to assess their antioxidant activity, inhibition activities of α-glucosidase, tyrosinase, and formation of advanced glycation endproducts; and (3) to investigate correlations among the phytochemicals and biological activity. Common bean possesses the highest antioxidant activity and advanced glycation endproducts formation inhibition activity. Adzuki bean has the highest α-glucosidase inhibition activity, and mung bean has the highest tyrosinase inhibition activity. There are significant differences in phytochemical content and functional activities among the bean species investigated. Selecting beans can help treat diseases such as dermatological hyperpigmentation illness, type 2 diabetes and associated cardiovascular diseases.
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, South Xueyuan Road, Haidian District No.80, Beijing 100081, China; E-Mails:  yaoyang@caas.net.cn  (Y.Y.);  chengxz@caas.net.cn  (X.C.);  wanglx@caas.net.cn  (L.W.);  wangsh@caas.net.cn  (S.W.).
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Cheng
authors.forename: Lixia
authors.initials: L
authors.lastname: Wang
authors.forename: Suhua
authors.initials: S
authors.lastname: Wang
authors.forename: Guixing
authors.initials: G
authors.lastname: Ren
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D002681:China; D002851:Chromatography, High Pressure Liquid; D007887:Fabaceae / Q000737:chemistry* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D011485:Protein Binding; D000520:alpha-Glucosidases / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D062385:Hydroxybenzoates; D010636:Phenols; D014442:Monophenol Monooxygenase; D000520:alpha-Glucosidases; C017616:phenolic acid
references.citation: J Invest Dermatol. 1989 Jul;93(1):100-7
references.pmid: 2501395
references.citation: J Agric Food Chem. 2006 May 31;54(11):3807-14
references.pmid: 16719500
references.citation: Diabetes Res Clin Pract. 1998 Jul;40 Suppl:S27-8
references.pmid: 9740499
references.citation: J Agric Food Chem. 2008 Oct 8;56(19):8869-73
references.pmid: 18767859
references.citation: Nitric Oxide. 2004 Jun;10(4):179-93
references.pmid: 15275864
references.citation: Redox Rep. 2002;7(1):23-8
references.pmid: 11981451
references.citation: Free Radic Res. 1995 Apr;22(4):375-83
references.pmid: 7633567
references.citation: Int J Food Sci Nutr. 2012 Feb;63(1):117-24
references.pmid: 21809904
references.citation: J Nutr Biochem. 2003 May;14(5):288-94
references.pmid: 12832033
references.citation: Naturwissenschaften. 1977 Oct;64(10):536-7
references.pmid: 927538
references.citation: Bioorg Med Chem. 2001 May;9(5):1233-40
references.pmid: 11377181
references.citation: J Ethnopharmacol. 2011 Jul 14;136(3):496-503
references.pmid: 20633623
references.citation: J Cell Sci. 2001 Jun;114(Pt 12):2335-44
references.pmid: 11493672
references.citation: J Food Sci. 2010 Jan-Feb;75(1):C9-13
references.pmid: 20492156
references.citation: J Pept Sci. 2006 Aug;12(8):509-14
references.pmid: 16680798
references.citation: J Agric Food Chem. 2006 Oct 4;54(20):7544-55
references.pmid: 17002420
references.citation: J Food Sci. 2007 Mar;72(2):S167-77
references.pmid: 17995859
references.citation: J Agric Food Chem. 2001 Mar;49(3):1620-4
references.pmid: 11312905
references.citation: Biosci Biotechnol Biochem. 2004 Dec;68(12):2421-6
references.pmid: 15618610
references.citation: Eur J Pharmacol. 2008 Mar 17;582(1-3):162-7
references.pmid: 18230397
references.citation: J Agric Food Chem. 2010 Feb 24;58(4):2221-9
references.pmid: 20095617
references.citation: J Agric Food Chem. 2010 Jan 27;58(2):770-4
references.pmid: 19904935