title: Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse.
abstract: In this paper the performance of cerebrospinal fluid (CSF) protein biomarkers important for monitoring damage of brain astrocytes and neurons for MS is reviewed. We estimated neurofilament, tau and phospho-tau proteins, β-APP, Aβ, S-100B and neuron-specific enolase in CSF of MS patients during relapse. We noted elevation of neurofilament, tau and phospho-tau proteins, S-100B, neuron-specific enolase and c-terminal epitopes of β-APP; concomitantly decrease of Aβ was observed. These CSF biomarkers for MS relapse should reflect the central pathogenic processes in the brain, i.e., axonal and neuronal degeneration.
authors.affiliation: Department of Neurology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Mitosek-Szewczyk
authors.forename: Wanda
authors.initials: W
authors.lastname: Gordon-Krajcer
authors.forename: Dorota
authors.initials: D
authors.lastname: Flis
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Stelmasiak
mesh_terms: D000328:Adult; D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid*; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D012008:Recurrence; D009418:S100 Proteins / Q000134:cerebrospinal fluid; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers; D009418:S100 Proteins; D016875:tau Proteins; D010751:Phosphopyruvate Hydratase