title: UniPathway: a resource for the exploration and annotation of metabolic pathways.
abstract: UniPathway (http://www.unipathway.org) is a fully manually curated resource for the representation and annotation of metabolic pathways. UniPathway provides explicit representations of enzyme-catalyzed and spontaneous chemical reactions, as well as a hierarchical representation of metabolic pathways. This hierarchy uses linear subpathways as the basic building block for the assembly of larger and more complex pathways, including species-specific pathway variants. All of the pathway data in UniPathway has been extensively cross-linked to existing pathway resources such as KEGG and MetaCyc, as well as sequence resources such as the UniProt KnowledgeBase (UniProtKB), for which UniPathway provides a controlled vocabulary for pathway annotation. We introduce here the basic concepts underlying the UniPathway resource, with the aim of allowing users to fully exploit the information provided by UniPathway.
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland. anne.morgat@isb-sib.ch
authors.forename: Anne
authors.initials: A
authors.lastname: Morgat
authors.forename: Eric
authors.initials: E
authors.lastname: Coissac
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Coudert
authors.forename: Kristian B
authors.initials: KB
authors.lastname: Axelsen
authors.forename: Guillaume
authors.initials: G
authors.lastname: Keller
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Alan
authors.initials: A
authors.lastname: Bridge
authors.forename: Lydie
authors.initials: L
authors.lastname: Bougueleret
authors.forename: Ioannis
authors.initials: I
authors.lastname: Xenarios
authors.forename: Alain
authors.initials: A
authors.lastname: Viari
mesh_terms: D016208:Databases, Factual; D030562:Databases, Protein; D004798:Enzymes / Q000378:metabolism; D008239:Lysine / Q000096:biosynthesis; D053858:Metabolic Networks and Pathways; D058977:Molecular Sequence Annotation
chemical_list: D004798:Enzymes; D008239:Lysine
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