title: Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives.
abstract: A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil. hstefani@usp.br
authors.forename: Hélio A
authors.initials: HA
authors.lastname: Stefani
authors.forename: Giancarlo V
authors.initials: GV
authors.lastname: Botteselle
authors.forename: Julio
authors.initials: J
authors.lastname: Zukerman-Schpector
authors.forename: Ignez
authors.initials: I
authors.lastname: Caracelli
authors.forename: Denis
authors.initials: D
authors.lastname: da Silva Corrêa
authors.forename: Sandra H P
authors.initials: SH
authors.lastname: Farsky
authors.forename: Isabel D
authors.initials: ID
authors.lastname: Machado
authors.forename: José R
authors.initials: JR
authors.lastname: Santin
authors.forename: Cristina B
authors.initials: CB
authors.lastname: Hebeda
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D020134:Catalytic Domain; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008958:Models, Molecular
chemical_list: D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2