title: Measurement of vascular tone and stroke volume baroreflex gain.
abstract: The arterial baroreflex system (BRS) consists of at least three closed-loop control systems: the heart rate (HR), vascular tone (VT), and stroke volume (SV) BRSs. Whereas HR-BRS gain is well studied, VT-BRS and SV-BRS gain are not. This study aimed to develop a method for quantifying VT-BRS and SV-BRS gain using an established HR-BRS gain measurement approach. ECG and beat-to-beat blood pressure (BP) were recorded in 31 young healthy participants during three tasks. Sequences of R-to-R wave intervals (RRI) of the ECG, pulse transit time (PTT), and SV were measured to assess HR-, VT-, and SV-BRS gain using the cross-spectral technique of computing the BP-RRI, BP-PTT, and BP-SV transfer functions. Gain in each BRS arch was measured in individuals with intact BRS functioning. Functional overlap and independence was noted in the BRS arches. The implications of the proposed method are discussed.
authors.affiliation: Center of Alcohol Studies, Rutgers-The State University of New Jersey, Piscataway, New Jersey 08854, USA. evaschil@rci.rutgers.edu
authors.forename: Evgeny G
authors.initials: EG
authors.lastname: Vaschillo
authors.forename: Bronya
authors.initials: B
authors.lastname: Vaschillo
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Buckman
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Pandina
authors.forename: Marsha E
authors.initials: ME
authors.lastname: Bates
mesh_terms: D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D013318:Stroke Volume / Q000502:physiology*; D055815:Young Adult
references.citation: J Physiol. 1999 Jun 1;517 ( Pt 2):617-28
references.pmid: 10332107
references.citation: Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2252-73
references.pmid: 15231503
references.citation: Sleep Med. 2005 May;6(3):199-203
references.pmid: 15854849
references.citation: Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2274-86
references.pmid: 15231504
references.citation: Physiol Meas. 2009 Feb;30(2):201-13
references.pmid: 19179747
references.citation: Biol Psychol. 2004 Nov;67(3):385-95
references.pmid: 15294394
references.citation: Eur Heart J. 2006 Feb;27(3):302-9
references.pmid: 16267075
references.citation: Psychosom Med. 2003 Sep-Oct;65(5):796-805
references.pmid: 14508023
references.citation: J Cardiovasc Electrophysiol. 2005 Jul;16(7):727-31
references.pmid: 16050830
references.citation: J Appl Physiol (1985). 2007 Apr;102(4):1348-56
references.pmid: 17185500
references.citation: Thorax. 1999 May;54(5):452-7
references.pmid: 10212114
references.citation: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:888-91
references.pmid: 19963478
references.citation: Exp Physiol. 2005 Jul;90(4):437-46
references.pmid: 15802289
references.citation: Psychophysiology. 2006 Jan;43(1):41-5
references.pmid: 16629684
references.citation: Psychophysiology. 2009 Sep;46(5):932-8
references.pmid: 19497015
references.citation: J Physiol. 1992 Mar;448:539-50
references.pmid: 1593476
references.citation: J Affect Disord. 2000 Dec;61(3):201-16
references.pmid: 11163422
references.citation: Circ Res. 1969 Jan;24(1):109-21
references.pmid: 4303309