title: Case report: cytomegalovirus-induced thrombosis in an immunocompetent patient.
abstract: Thrombotic manifestations of cytomegalovirus infection in immunocompetent individuals are rare. However, it has been postulated that cytomegalovirus infection can be both directly cytopathic and capable of inducing antiphospholipid antibodies due to shared "molecular mimicry" between cytomegalovirus virus antigens and antiphospholipid antibodies. The case of a previously well 30-year-old woman with primary cytomegalovirus infection complicated by splenic infarction and massive pulmonary embolus is described. The patient is unusual given the development of thromboses affecting both the arterial and venous circulation, associated with both transient anticardiolipin antibodies and persistently positive anti-β(2) glycoprotein I antibodies. The temporal relationship between the primary infection and thrombosis was suggestive of a pathogenic role for cytomegalovirus.
authors.affiliation: Department of Hematology Oncology, National University Hospital, Singapore, Singapore.
authors.forename: Michelle L M
authors.initials: ML
authors.lastname: Poon
authors.forename: Julian W
authors.initials: JW
authors.lastname: Tang
authors.forename: Yen Lin
authors.initials: YL
authors.lastname: Chee
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000473:pathology; D011860:Radiography, Abdominal; D013902:Radiography, Thoracic; D013159:Splenic Infarction / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D013927:Thrombosis / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M