title: Efficacy of acitretin for porokeratosis in a child with chronic cutaneous graft versus host disease.
abstract: Porokeratosis is a rare disorder of epidermal keratinization that is regarded as a precancerous. Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor. A 16-year-old boy who had received HSCT for acute myelogenous leukemia was referred to us for sclerodermoid chronic cutaneous GVHD. Two years later, he developed disseminated porokeratosis with a few atypical lesions. Despite cryotherapy, numerous lesions of porokeratosis recurred rapidly. Acitretin resulted in good clinical response and reduced the rate of onset of new lesions.
authors.affiliation: Molecular Diagnostics Laboratory, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. r.borroni@smatteo.pv.it
authors.forename: Riccardo G
authors.initials: RG
authors.lastname: Borroni
authors.forename: Dimitri
authors.initials: D
authors.lastname: Poddighe
authors.forename: Marco
authors.initials: M
authors.lastname: Zecca
authors.forename: Valeria
authors.initials: V
authors.lastname: Brazzelli
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000293:Adolescent; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D017499:Porokeratosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D017255:Acitretin