title: [Relationship between angiotensin converting enzyme gene polymorphism and essential hypertension in children].
abstract: OBJECTIVE
  To study the relationship between insertion/deletion (I/D) polymorphism of 287 bp in the 16th intron of angiotensin converting enzyme (ACE) and essential hypertension in children.
  
  
  METHODS
  I/D polymorphism of 287 bp in the 16th intron of ACE was detected using PCR in 105 children with essential hypertension and 105 normal children as control group.
  
  
  RESULTS
  There was an I/D polymorphism in the 16th intron of ACE in the hypertension and the control groups: type II, type ID and type DD. The genotype frequencies of type DD, type ID and type II in the hypertension group were 30.5%, 47.6% and 21.9%, respectively. The genotype frequencies of type DD, type ID and type II in the control group were 14.3%, 46.7% and 39.1%, respectively. There were significant differences in the genotype frequencies of types DD and II between the two groups (P<0.01). The allele frequency of type D (54.3% vs 37.6%) was significantly higher in the hypertension group; in contrast, the allele frequency of type I (45.7% vs 62.4%) was significantly lower than in the control group (P<0.01).
  
  
  CONCLUSIONS
  Polymorphism of type II, type ID and type DD exits in ACE. The deletion of 287 bp in the 16th intron of ACE might be associated with the occurrence of essential hypertension in children.
authors.affiliation: Department of Pediatrics, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Li
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Song
authors.forename: Hai
authors.initials: H
authors.lastname: Su
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Cao
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A