title: Emerging technologies for enabling proangiogenic therapy.
abstract: Ischemic disease causes a large number of deaths and significant clinical problems worldwide. Therapeutic angiogenesis, strengthened by advances in growth-factor-based therapies, is a promising solution to ischemic pathologies. Major challenges in therapeutic angiogenesis are the lack of stability of native angiogenic proteins and also providing sustained delivery of biologically active proteins at the ischemic sites. This paper will discuss various protein engineering strategies to develop stabilized proangiogenic proteins and several biomaterial technologies used to amplify the angiogenic outcome by delivering biologically active growth factors in a sustained manner.
authors.affiliation: Department of Biological and Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur Campus, P O BCKV Campus Mail Office, West Bengal 741252, India. rituparna@iiserkol.ac.in
authors.forename: Rituparna Sinha
authors.initials: RS
authors.lastname: Roy
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Roy
authors.forename: Shiladitya
authors.initials: S
authors.lastname: Sengupta
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use*; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry; D018919:Neovascularization, Physiologic / Q000187:drug effects; D015202:Protein Engineering / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D043925:Angiogenesis Inducing Agents; D036341:Intercellular Signaling Peptides and Proteins