title: Heritability and longitudinal stability of impulsivity in adolescence.
abstract: Impulsivity is a multifaceted personality construct that plays an important role throughout the lifespan in psychopathological disorders involving self-regulated behaviors. Its genetic and environmental etiology, however, is not clearly understood during the important developmental period of adolescence. This study investigated the relative influence of genes and environment on self-reported impulsive traits in adolescent twins measured on two separate occasions (waves) between the ages of 11 and 16. An adolescent version of the Barratt Impulsiveness Scale (BIS) developed for this study was factored into subscales reflecting inattention, motor impulsivity, and non-planning. Genetic analyses of these BIS subscales showed moderate heritability, ranging from 33-56% at the early wave (age 11-13 years) and 19-44% at the later wave (age 14-16 years). Moreover, genetic influences explained half or more of the variance of a single latent factor common to these subscales within each wave. Genetic effects specific to each subscale also emerged as significant, with the exception of motor impulsivity. Shared twin environment was not significant for either the latent or specific impulsivity factors at either wave.  Phenotypic correlations between waves ranged from r = 0.25 to 0.42 for subscales. The stability correlation between the two latent impulsivity factors was r = 0.43, of which 76% was attributable to shared genetic effects, suggesting strong genetic continuity from mid to late adolescence. These results contribute to our understanding of the nature of impulsivity by demonstrating both multidimensionality and genetic specificity to different facets of this complex construct, as well as highlighting the importance of stable genetic influences across adolescence.
authors.affiliation: Department of Psychology, University of Southern California, 3620 S. McClintock Ave., Los Angeles, CA 90089-1061, USA. sniv@usc.edu
authors.forename: Sharon
authors.initials: S
authors.lastname: Niv
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuvblad
authors.forename: Adrian
authors.initials: A
authors.lastname: Raine
authors.forename: Pan
authors.initials: P
authors.lastname: Wang
authors.forename: Laura A
authors.initials: LA
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics* / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D008957:Models, Genetic; D009483:Neuropsychological Tests; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
references.citation: Behav Genet. 2000 Jan;30(1):1-18
references.pmid: 10934795
references.citation: Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
references.pmid: 10817843
references.citation: Twin Res Hum Genet. 2006 Dec;9(6):933-40
references.pmid: 17254433
references.citation: Br J Psychiatry Suppl. 1989 Dec;(8):52-62
references.pmid: 2692640
references.citation: J Abnorm Psychol. 2007 May;116(2):219-35
references.pmid: 17516756
references.citation: Pediatr Ann. 1989 Feb;18(2):122, 124, 125 passim
references.pmid: 2648277
references.citation: J Am Acad Child Adolesc Psychiatry. 2007 Mar;46(3):309-322
references.pmid: 17314717
references.citation: J Pers Soc Psychol. 1988 Dec;55(6):950-7
references.pmid: 3216289
references.citation: J Abnorm Child Psychol. 1999 Apr;27(2):151-65
references.pmid: 10400061
references.citation: Twin Res Hum Genet. 2007 Apr;10(2):373-8
references.pmid: 17564527
references.citation: Drug Alcohol Depend. 2007 Dec 1;91(2-3):213-9
references.pmid: 17629632
references.citation: Behav Genet. 1998 May;28(3):173-86
references.pmid: 9670593
references.citation: Psychiatry Res. 1993 Sep;48(3):229-42
references.pmid: 8272445
references.citation: Child Dev. 1995 Apr;66(2):486-98
references.pmid: 7750379
references.citation: Br J Soc Clin Psychol. 1977 Feb;16(1):57-68
references.pmid: 843784
references.citation: J Pers Soc Psychol. 2002 Dec;83(6):1456-68
references.pmid: 12500824
references.citation: Int J Psychophysiol. 2005 Oct;58(1):59-70
references.pmid: 15950304
references.citation: Behav Genet. 1978 Sep;8(5):437-73
references.pmid: 570035
references.citation: Dev Sci. 2007 Mar;10(2):F8-F14
references.pmid: 17286837
references.citation: J Abnorm Psychol. 1994 May;103(2):192-205
references.pmid: 8040489
references.citation: Assessment. 2000 Dec;7(4):329-45
references.pmid: 11172584
references.citation: Percept Mot Skills. 2002 Oct;95(2):621-35
references.pmid: 12434861
references.citation: J Clin Psychol. 1995 Nov;51(6):768-74
references.pmid: 8778124
references.citation: J Abnorm Psychol. 2006 May;115(2):221-30
references.pmid: 16737387
references.citation: Dev Rev. 2008;28(1):62-77
references.pmid: 18688292
references.citation: Am J Psychiatry. 2001 Nov;158(11):1783-93
references.pmid: 11691682
references.citation: Psychol Bull. 2002 May;128(3):490-529
references.pmid: 12002699
references.citation: Clin Psychol Rev. 2011 Nov;31(7):1209-23
references.pmid: 21889436
references.citation: Psychol Rep. 1983 Feb;52(1):147-52
references.pmid: 6844483
references.citation: Psychiatry Res. 1999 Apr 19;86(1):41-57
references.pmid: 10359481
references.citation: Aggress Behav. 2006 Apr 1;32(2):159-171
references.pmid: 20798781