title: [Genetic analysis for nicotine dependence].
abstract: Smoking cessation is extremely important to prevent the development of the serious diseases, such as COPD and cancers. Absorbed nicotine through smoking into the body is mainly metabolized by cytochrome P450 (CYP) 2A6. On the other, the nicotine acts in the brain through neuronal nicotinic acetylcholine receptors (nAChRs), which regulate the addictive properties of nicotine. Many associated studies have implicated genetic backgrounds influence smoking behavior and nicotine dependence. In these concepts, we here discuss the genes related to nicotine dependence from the pharmacokinetic and pharmacodynamic aspects of nicotine. Referring to the genome association studies, better understanding the molecular mechanisms of nicotine dependence would help to design targeted, more effective therapies for the tobacco-related diseases and smoking cessation program.
authors.affiliation: Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences.
authors.forename: Makiko
authors.initials: M
authors.lastname: Maeda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D014029:Tobacco Use Disorder / Q000235:genetics*
chemical_list: D003577:Cytochrome P-450 Enzyme System