title: Chondrosarcoma of the spine: a series of 16 cases and a review of the literature.
abstract: Only a few major studies of chondrosarcoma of the mobile spine have been reported. These studies have shown that spinal chondrosarcomas require complete surgical resection and are notoriously resistant to chemotherapy and radiation. We present 16 cases of chondrosarcoma of the mobile spine diagnosed at a median age of 54.5 (range 20 - 79) years. Diagnosis and treatment studies were based on both CT scans and MRI. Fifteen of our 16 patients had low-grade (grade 1-2) chondrosarcomas. All patients were treated with surgical resection. Fourteen patients had total resection while two patients had subtotal resection. The two patients who had subtotal resection died of their disease. Five of the fourteen patients who had total resection also died. The mean interval to death was 3.6 years. This study confirms that although chondrosarcomas of the spine are low grade, they are dangerous neoplasms. Even with complete resection, they have a high rate of recurrence and metastasis.
authors.affiliation: Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Sophia A
authors.initials: SA
authors.lastname: Strike
authors.forename: Edward F
authors.initials: EF
authors.lastname: McCarthy
mesh_terms: D000328:Adult; D000368:Aged; D002813:Chondrosarcoma / Q000401:mortality* / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012008:Recurrence; D013125:Spinal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D055815:Young Adult
references.citation: Diagn Pathol. 2006 Oct 30;1:39
references.pmid: 17074093
references.citation: Cancer. 2001 Apr 1;91(7):1201-12
references.pmid: 11283918
references.citation: Acta Radiol. 2006 Feb;47(1):77-84
references.pmid: 16498937
references.citation: Skeletal Radiol. 1987;16(1):37-44
references.pmid: 3823959
references.citation: Clin Orthop Relat Res. 2001 Oct;(391):224-33
references.pmid: 11603673
references.citation: Pediatr Radiol. 2007 Nov;37(11):1155-8
references.pmid: 17849111
references.citation: Spine (Phila Pa 1976). 2000 Apr 1;25(7):804-12
references.pmid: 10751291
references.citation: J Neurosurg Spine. 2008 Aug;9(2):120-8
references.pmid: 18764743
references.citation: Orthop Clin North Am. 2009 Jan;40(1):21-36, v
references.pmid: 19064053
references.citation: Clin Oncol (R Coll Radiol). 2007 Sep;19(7):509-16
references.pmid: 17524633
references.citation: Neoplasma. 2008;55(1):16-22
references.pmid: 18190235
references.citation: J Neurosurg Spine. 2006 May;4(5):424
references.pmid: 16703913
references.citation: J Neurosurg. 1999 Jan;90(1 Suppl):73-8
references.pmid: 10413129
references.citation: Plast Reconstr Surg. 2004 Nov;114(6):1534-8
references.pmid: 15509945
references.citation: J Bone Joint Surg Am. 1989 Sep;71(8):1158-65
references.pmid: 2777842
references.citation: Arq Neuropsiquiatr. 2004 Sep;62(3B):875-8
references.pmid: 15476087