title: Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats.
abstract: OBJECTIVE
  To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarckii (A. lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.
  
  
  METHODS
  Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water (2g/kg). Single dose of alcoholic leaves extract of A. lamarckii (250 and 500 mg/kg, p.o.) were administered to normoglycemic, hyperglycemic rats. Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide (110 mg/kg) followed by streptozotocin (65mg/kg). The study also included estimations of blood plasma glucose, lipid profile, liver glycogen, body weight and antioxidant status in normal and diabetic rats.
  
  
  RESULTS
  Admistration of alcoholic extract of A. lamarckii at two dosage 250 and 500 mg/kg, p.o. did not showed any significant change in blood glucose level of normoglycemic rats (P>0.05), whereas, oral glucose tolerance test depicted reduction in blood glucose level (P<0.05). The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level (P<0.001) comparable to glibenclamide (10 mg/kg), restored the lipid profile and showed improvement in liver glycogen, body weight and antioxidant status in diabetic rats.
  
  
  CONCLUSIONS
  Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of A. lamarckii.
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Pate
authors.forename: Satyendra Kuldip
authors.initials: SK
authors.lastname: Prasad
authors.forename: Kirshnamurthy
authors.initials: K
authors.lastname: Sairam
authors.forename: Siva
authors.initials: S
authors.lastname: Hemalatha
mesh_terms: D032604:Alangiaceae / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009536:Niacinamide; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D008055:Lipids; D008112:Liver Glycogen; D010936:Plant Extracts; D009536:Niacinamide; D013311:Streptozocin; D013482:Superoxide Dismutase