title: Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function?
abstract: In several species and in many vascular beds, ultrastructural studies describe close contact sites between the endothelium and smooth muscle of <∼20nm. Such sites are thought to facilitate the local action of signaling molecules and/or the passage of current, as metabolic and electrical coupling conduits between the arterial endothelium and smooth muscle. These sites have the potential for bidirectional communication between the endothelium and smooth muscle, as a key pathway for coordinating vascular function. The aim of this brief review is to summarize the literature on the ultrastructural anatomy and distribution of key components of MECC sites in arteries. In addition to their traditional role of facilitating electrical coupling between the two cell layers, data on the role of MECC sites in arteries, as signaling microdomains involving a spatial localization of channels, receptors and calcium stores are highlighted. Diversity in the density and specific characteristics of MECC sites as signaling microdomains suggests considerable potential for functional diversity within and between arteries in health and disease.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia. Shaun.Sandow@unsw.edu.au
authors.forename: Shaun L
authors.initials: SL
authors.lastname: Sandow
authors.forename: Sevvandi
authors.initials: S
authors.lastname: Senadheera
authors.forename: Paul P
authors.initials: PP
authors.lastname: Bertrand
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Murphy
authors.forename: Marianne
authors.initials: M
authors.lastname: Tare
mesh_terms: D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology; D004730:Endothelium, Vascular / Q000033:anatomy & histology / Q000502:physiology; D017629:Gap Junctions / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000033:anatomy & histology / Q000502:physiology