title: Recent mumps outbreaks in vaccinated populations: no evidence of immune escape.
abstract: Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape.
authors.affiliation: Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA. steven.rubin@fda.hhs.gov
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rubin
authors.forename: Malen A
authors.initials: MA
authors.lastname: Link
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Sauder
authors.forename: Cheryl
authors.initials: C
authors.lastname: Zhang
authors.forename: Laurie
authors.initials: L
authors.lastname: Ngo
authors.forename: Bert K
authors.initials: BK
authors.lastname: Rima
authors.forename: W Paul
authors.initials: WP
authors.lastname: Duprex
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008969:Molecular Sequence Data; D009107:Mumps / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D009109:Mumps virus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D010802:Phylogeny; D014481:United States / Q000453:epidemiology; D014611:Vaccination
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D022542:Measles-Mumps-Rubella Vaccine
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