title: Effect of Ginkgo biloba extract (GbE-761) on the survival of fasciocutaneous flaps in rats.
abstract: Cutaneous and fasciocutaneous flaps are used widely in the surgical reconstruction of various body segments, especially to cover exposed vital tissues. Partial or total necrosis of these flaps, secondary to insufficient tissue irrigation, is one possible complication. Therefore, investigations into antiplatelet aggregation, vasodilation and antioxidant properties are highly significant. The aim of the present study was to analyse the effect of GbE 761 on the survival of fasciocutaneous flaps in rats. For that purpose, GbE 761 was administered to 30 rats after the creation of 10 × 3 cm dorsal flaps on each animal. The rats were divided into three equal groups. GbE 761 was administered to Group A, starting immediately after surgery; Group B received it 24 h after the flap was cut; and Group C (controls) received 0.9% NaCl solution. The average area of necrosis was 29.53% in Group A, 26.25% in Group B and 46.12% in Group C. The difference between Groups B and C was statistically significant (p = 0.026). These initial findings suggest that GbE 761 administered on day 1 after surgery reduces the percentage of necrosis in fasciocutaneous flaps, relative to not giving GbE at all.
authors.affiliation: Department of Orthopedics and Traumatology, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, SP, Brazil.
authors.forename: Marina T C
authors.initials: MT
authors.lastname: Sambuy
authors.forename: Antonio C da
authors.initials: AC
authors.lastname: Costa
authors.forename: Carina
authors.initials: C
authors.lastname: Cohen
authors.forename: Ivan
authors.initials: I
authors.lastname: Chakkour
mesh_terms: D000818:Animals; D020441:Ginkgo biloba / Q000737:chemistry; D009336:Necrosis / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps / Q000473:pathology; D000096983:Ginkgo Extract
chemical_list: D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract