title: Selective adsorption of proteins on single-wall carbon nanotubes by using a protective surfactant.
abstract: The dispersion of highly hydrophobic carbon materials such as carbon nanotubes in biological media is a challenging issue. Indeed, the nonspecific adsorption of proteins occurs readily when the nanotubes are introduced in biological media; therefore, a methodology to control adsorption is in high demand. To address this issue, we developed a bifunctional linker derived from pyrene that selectively enables or prevents the adsorption of proteins on single-wall carbon nanotubes (SWNTs). We demonstrated that it is possible to decrease or completely suppress the adsorption of proteins on the nanotube sidewall by using proper functionalization (either covalent or noncovalent). By subsequently activating the functional groups on the nanotube derivatives, protein adsorption can be recovered and, therefore, controlled. Our approach is simple, straightforward, and potentially suitable for other biomolecules that contain thio or amino groups available for coupling.
authors.affiliation: Université Paris 11, Laboratoire de Physique des Solides, UMR 8502, 91405 Orsay, France. anton.knyazev@epfl.ch
authors.forename: Anton
authors.initials: A
authors.lastname: Knyazev
authors.forename: Loïc
authors.initials: L
authors.lastname: Louise
authors.forename: Michèle
authors.initials: M
authors.lastname: Veber
authors.forename: Dominique
authors.initials: D
authors.lastname: Langevin
authors.forename: Arianna
authors.initials: A
authors.lastname: Filoramo
authors.forename: Adriele
authors.initials: A
authors.lastname: Prina-Mello
authors.forename: Stéphane
authors.initials: S
authors.lastname: Campidelli
mesh_terms: D000327:Adsorption; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D011506:Proteins; D011721:Pyrenes; D011760:Pyrrolidinones; D013501:Surface-Active Agents; D012710:Serum Albumin, Bovine; C038678:N-methylpyrrolidone