title: Anticandidal activity of the essential oil of Nepeta transcaucasica Grossh.
abstract: Hydrodistallation of the aerial parts of Nepeta transcaucasica Grossh. (Lamiaceae), collected in Ağrı, Doğubayazıt Province, afforded an essential oil that was characterized by GC and GC/MS analyses. Twenty-seven compounds, representing 97.69% of the total oil composition, were identified, and 4aα,7α,7aβ-nepetalactone (1; 39%), 4aα,7α,7aα-nepetalactone (2; 28%), and germacrene D (3; 15%) constituted the major components. The anticandidal effects of the oil were evaluated against seven Candida strains by using the broth microdilution method. The oil showed good inhibitory effects against C. glabrata and C. tropicalis at minimal inhibitory concentrations (MICs) of 0.09 and 0.375 mg/ml, respectively.
authors.affiliation: Department of Pharmacognosy, Anadolu University, Faculty of Pharmacy, Eskişehir. giscan@anadolu.edu.tr
authors.forename: Gökalp
authors.initials: G
authors.lastname: Işcan
authors.forename: Y Bülent
authors.initials: YB
authors.lastname: Köse
authors.forename: Betül
authors.initials: B
authors.lastname: Demirci
authors.forename: K Hüsnü Can
authors.initials: KH
authors.lastname: Başer
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D027521:Nepeta / Q000737:chemistry* / Q000254:growth & development; D009822:Oils, Volatile / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry / Q000254:growth & development; D010938:Plant Oils / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile; D010938:Plant Oils