title: [Significance of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and lectin-reactive alpha-fetoprotein (AFP-L3) expresssion in primary hepatic carcinoma].
abstract: OBJECTIVE
  To explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and the percentage of lectin-reactive aipha-fetoprotein (AFP-L3) of primary hepatic carcinoma (PHC), and provide a novel method for diagnosis for PHC and screening for high-risk population.
  
  
  METHODS
  ELISA was used to detect the serum level of GP73, AFP and AFP-L3% in 81 cases of PHC,176 cases chronic hepatitis and liver cirrhosis, 30 cases other tumber cancer and 40 cases of health people.
  
  
  RESULTS
  The sensitivity of GP73, AFP and AFP-L3% in PHC is 77.78%, 62.69% and 51.85%, and the specificity is 84.55%, 86.99% and 96.34%, respectively. Joint detection could increase the sensitivity up to 88.89%.
  
  
  CONCLUSIONS
  GP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3% was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.
authors.affiliation: Shaoxing Sixth People's Hospital, Zhejiang, China.
authors.forename: Wen-fang
authors.initials: WF
authors.lastname: Xu
authors.forename: Ying-ming
authors.initials: YM
authors.lastname: Fei
authors.forename: Jian-kang
authors.initials: JK
authors.lastname: Zhou
authors.forename: Hua-jing
authors.initials: HJ
authors.lastname: Shen
authors.forename: Xue-fang
authors.initials: XF
authors.lastname: Chen
authors.forename: Qiu-qiong
authors.initials: QQ
authors.lastname: Lv
authors.forename: Yu-yun
authors.initials: YY
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D020033:Protein Isoforms / Q000097:blood / Q000235:genetics / Q000378:metabolism; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C410824:GOLM1 protein, human; D008565:Membrane Proteins; D020033:Protein Isoforms; D000509:alpha-Fetoproteins