title: [The assessment of hemoperfusion for the treatment of acute methamidophos poisoning].
abstract: OBJECTIVE
  To explore the effect of hemoperfusion(HP) about the patients of methamidophos poisoning.
  
  
  METHODS
  On the basis of comprehensive treatment,15 cases of severe acute methamidophos poisoning patients were treated with HP, Blood samples were collected at 7 time points, before and 5, 15, 30, 45, 60mins following the beginning and the end of hemoperfusion. Blood samples were used for measuring the concentration of methamidophos and perfusion devices were used for measuring the volume of methamidophos adsorbed by the device after hemoperfusion.
  
  
  RESULTS
  15 patients live in 12 cases, 3 cases of death. HP (former) blood Cholinesterase vigor were 662.60 + 632.05, HP (after) blood cholinesterase vigor were 2577.52 + 920.38 IU/L; The difference of blood Cholinesterase vigor between the before and after HP was statistically significant (P < 0.01). The patients' methamidophos concentration of blood when HP treated 45, 60, 120 min were respectively (851 + 672), (680 + 529), (587 + 520) microg /ml, there were significantly lower than that the patients' methamidophos concentration of blood who were before HP (1659 + 1105) microg/ml, a statistically significant difference (P < 0.01).
  
  
  CONCLUSIONS
  HP can be cut down obviously methamidophos poisoning patients serum concentrations of toxic, the experimental method directly prove the clinical application of carbon HP can really adsorption methamidophos.
authors.affiliation: Emergency Department of the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
authors.forename: Deng-Pan
authors.initials: DP
authors.lastname: Lai
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Ju-Ping
authors.initials: JP
authors.lastname: Yao
authors.forename: Yi-Fen
authors.initials: YF
authors.lastname: Wang
authors.forename: Guo-Qin
authors.initials: GQ
authors.lastname: Cheng
mesh_terms: D000328:Adult; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014655:methamidophos; D002802:Cholinesterases