title: MicroRNAs: toward the clinic for breast cancer patients.
abstract: Expression of microRNAs (miRNAs) has been found to be deregulated in all human cancers, where they may behave either as oncogenes or as tumor-suppressor genes. In the last 5 years, miRNA investigations in breast cancer represented an exciting area of discovery, which produced new knowledge on the molecular basis of this disease, tools for molecular classification, and new markers with diagnostic and prognostic relevance, as well as the discovery of novel breast cancer-predisposing genes. In this review, we describe current knowledge of the role of microRNAs in breast cancer.
authors.affiliation: Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy. manuela.ferracin@unife.it
authors.forename: Manuela
authors.initials: M
authors.lastname: Ferracin
authors.forename: Patrizia
authors.initials: P
authors.lastname: Querzoli
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Massimo
authors.initials: M
authors.lastname: Negrini
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009362:Neoplasm Metastasis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D035683:MicroRNAs