title: Neuropsychological function and past exposure to metallic mercury in female dental workers.
abstract: The aim of this study was to see if dental personnel with previous exposure to metallic mercury have later developed disturbances in cognitive function. Ninety-one female participants who had been selected from a previous health survey of dental personnel were investigated neuropsychologically within the following domains: motor function, short-term memory, working memory, executive function, mental flexibility, and visual and verbal long-term memory. The scores were mainly within normal ranges. Relationships between an exposure score, the duration of employment before 1990, and previously measured mercury in urine as independent variables and the neuropsychological findings as dependent variables, were analyzed by multiple linear regression controlling for age, general ability, length of education, alcohol consumption, and previous head injuries. The only relationship that was statistically significant in the hypothesized direction was between the previously measured urine mercury values and visual long-term memory, where the urine values explained 30% of the variability. As the study had a low statistical power and also some other methodological limitations, the results have to be interpreted with caution. Even so, we think it is right to conclude that neuropsychological findings indicative of subsequent cognitive injuries are difficult to find in groups of otherwise healthy dental personnel with previous occupational exposure to mercury.
authors.affiliation: Department of Industrial Economics and Technology Management, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Helge
authors.initials: H
authors.lastname: Sletvold
authors.forename: Kristin
authors.initials: K
authors.lastname: Svendsen
authors.forename: Oddfrid
authors.initials: O
authors.lastname: Aas
authors.forename: Tore
authors.initials: T
authors.lastname: Syversen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Hilt
mesh_terms: D000328:Adult; D000368:Aged; D003797:Dental Staff; D056344:Executive Function; D005260:Female; D006801:Humans; D008568:Memory; D008628:Mercury / Q000652:urine*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009664:Norway; D016273:Occupational Exposure
chemical_list: D008628:Mercury
references.citation: Scand J Work Environ Health. 2010 May;36(3):231-41
references.pmid: 19953215
references.citation: Br J Ind Med. 1992 Nov;49(11):782-90
references.pmid: 1463679
references.citation: Environ Toxicol Pharmacol. 2005 May;19(3):517-22
references.pmid: 21783521
references.citation: Neurotoxicology. 2009 Nov;30(6):1202-6
references.pmid: 19427330
references.citation: Lancet. 1974 Sep 14;2(7881):605-9
references.pmid: 4137603
references.citation: J Dent Res. 2010 Nov;89(11):1236-40
references.pmid: 20739704
references.citation: Int Dent J. 2003 Apr;53(2):85-91
references.pmid: 12731695
references.citation: J Clin Exp Neuropsychol. 1986 Oct;8(5):581-93
references.pmid: 3805254
references.citation: J Psychosom Res. 1997 Mar;42(3):297-306
references.pmid: 9130186
references.citation: Neurotoxicology. 2001 Apr;22(2):249-58
references.pmid: 11405256
references.citation: Neurotoxicol Teratol. 2006 Jan-Feb;28(1):39-48
references.pmid: 16343843
references.citation: Occup Environ Med. 2002 May;59(5):287-93
references.pmid: 11983843
references.citation: J Dent. 2003 Sep;31(7):487-92
references.pmid: 12927460
references.citation: J Rheumatol. 1995 Jan;22(1):137-42
references.pmid: 7699660
references.citation: FASEB J. 1998 Aug;12(11):971-80
references.pmid: 9707169
references.citation: Neurotoxicol Teratol. 1995 Mar-Apr;17(2):161-8
references.pmid: 7760775
references.citation: J Neurol Neurosurg Psychiatry. 1996 May;60(5):564-71
references.pmid: 8778265
references.citation: Clin Neuropsychol. 2006 Feb;20(1):108-32
references.pmid: 16393923
references.citation: Braz J Med Biol Res. 2007 Mar;40(3):425-33
references.pmid: 17334541
references.citation: Braz J Med Biol Res. 2007 Mar;40(3):409-14
references.pmid: 17334539
references.citation: Hum Exp Toxicol. 2007 Apr;26(4):367-74
references.pmid: 17615119
references.citation: J Am Dent Assoc. 1995 Nov;126(11):1495-501
references.pmid: 7499646
references.citation: Occup Environ Med. 1995 Dec;52(12):813-7
references.pmid: 8563844
references.citation: J Neurol Sci. 2004 Feb 15;217(2):211-6
references.pmid: 14706226
references.citation: Arch Toxicol. 2004 Apr;78(4):207-11
references.pmid: 14598023
references.citation: Neurotoxicol Teratol. 2005 Nov-Dec;27(6):781-96
references.pmid: 16301096
references.citation: Neurotoxicology. 2002 Dec;23(6):711-7
references.pmid: 12520761
references.citation: Br J Psychiatry. 1995 Jul;167(1):95-8
references.pmid: 7551618
references.citation: Neuropsychiatry Neuropsychol Behav Neurol. 2001 Oct-Dec;14(4):233-40
references.pmid: 11725217
references.citation: Toxicol Sci. 2004 Oct;81(2):354-63
references.pmid: 15254338
references.citation: Scand J Work Environ Health. 1999 Aug;25(4):342-50
references.pmid: 10505660
references.citation: Neurotoxicology. 2005 Jun;26(3):427-37
references.pmid: 15935213