title: PLA-based biodegradable and tunable soft elastomers for biomedical applications.
abstract: Although desirable for biomedical applications, soft degradable elastomers having balanced amphiphilic behaviour are rarely described in the literature. Indeed, mainly highly hydrophobic elastomers or very hydrophilic elastomers with hydrogel behaviours are found. In this work, we developed thermoset degradable elastomers based on the photo-cross-linking of poly(lactide)-poly(ethylene glycol)-poly(lactide) (PLA-PEG-PLA) triblock prepolymers. The originality of the proposed elastomers comes from the careful choice of the prepolymer amphiphilicity and from the possible modulation of their mechanical properties and degradation rates provided by cross-linkers of different nature. This is illustrated with the hydrophobic and rigid 2,4,6-triallyloxy-1,3,5-triazine compared to the hydrophilic and soft pentaerythritol triallyl ether. Thermal properties, mechanical properties, swelling behaviours, degradation rates and cytocompatibility have been evaluated. Results show that it is possible to generate a family of degradable elastomers covering a broad range of properties from a single biocompatible and biodegradable prepolymer.
authors.affiliation: Faculty of Pharmacy, Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247 University of Montpellier 1, University of Montpellier 2, 15 Av. C. Flahault, Montpellier 34093, France.
authors.forename: Amine
authors.initials: A
authors.lastname: Harrane
authors.forename: Adrien
authors.initials: A
authors.lastname: Leroy
authors.forename: Hélène
authors.initials: H
authors.lastname: Nouailhas
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
authors.forename: Jean
authors.initials: J
authors.lastname: Coudane
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nottelet
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry*; D019245:Compressive Strength; D020724:Elastomers / Q000737:chemistry*; D006244:Hardness; D007773:Lactates / Q000737:chemistry*; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D007773:Lactates; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols