title: Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation on the CCL-110 skin fibroblast cell line.
abstract: Coenzyme Q10 (CoQ10) is a major ingredient in skin care products because of its anti-wrinkle effects, although it has some side effects especially at higher amounts. In this study, we compare the anti-wrinkle related properties of CoQ10 and a proprietary Commiphora mukul gum resin (guggul) and triheptanoin preparation (GU-TC7). GU-TC7 is prepared with a supercritical CO₂-co-solvent extraction with ethanol, standardized to 2% guggulsterones and triheptanoin, a triglyceride composed of three 7-carbon fatty acids. Treatment of CCL-110 skin fibroblasts with GU-TC7 demonstrates a mild proliferative effect compared to CoQ10 and increased type I collagen synthesis. Additionally, GU-TC7 inhibited matrix metalloproteinase-1 (MMP-1) expression in a dose-dependent manner at 20-100 μg mL⁻¹ and inhibited human elastase expression by more than 50% as compared to no elastase inhibition with CoQ10 treatment. These results suggest that GU-TC7 possesses properties that are applicable to the treatment of wrinkles and may be considered for its further evaluation in skin care products.
authors.affiliation: Dharma Biomedical LLC, 12777 Old Cutler Road, Miami, FL 33156, USA. cheppail.ramachandran@mch.com
authors.forename: C
authors.initials: C
authors.lastname: Ramachandran
authors.forename: K-W
authors.initials: KW
authors.lastname: Quirin
authors.forename: A
authors.initials: A
authors.lastname: Resek
authors.forename: S J
authors.initials: SJ
authors.lastname: Melnick
mesh_terms: D002460:Cell Line; D024042:Collagen Type I / Q000096:biosynthesis / Q000378:metabolism; D029744:Commiphora / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D024042:Collagen Type I; D010936:Plant Extracts; D014280:Triglycerides; C531010:triheptanoin; D010196:Pancreatic Elastase; D020781:Matrix Metalloproteinase 1