title: Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children.
abstract: OBJECTIVE
  The aim of the study was to determine whether increased intake of DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) would affect the weight loss or the various biochemical parameters in the blood of obese children following dietary/physical intervention. There were 120 obese (BMIs≥30 kg/m(2); mean 33.5 ± 3.9) children included in this randomized crossover study; aged 8-12 years (10.0 ± 1.9).
  
  
  METHODS
  The children consumed an extra 300 mg DHA and 42 mg EPA (Haliborange ®) daily for a period of 3 weeks. Anthropometric and biochemical parameters were measured and documented for each of the subjects at the beginning of the study, after three weeks of treatment and at the end of the study.
  
  
  RESULTS
  The daily consumption of 300 mg DHA and 42 mg of EPA was associated with decreased body weight (with DHA: 86.4 ± 19.6 to 80.8 ± 20.4 kg vs. without DHA: 85.6 ± 20.8 to 80.9 ± 19.9 kg; p<0.005) and total cholesterol concentration (with DHA: 3.72 ± 0.78 to 3.32 ± 0.53 mmol/l vs. without DHA: 3.74 ± 0.78 to 3.56 ± 0.56 mmol/l; p<0.05 and respectively with DHA).
  
  
  CONCLUSIONS
  Daily consumption of 300 mg DHA and 42 mg EPA (Haliborange®) for 3 weeks leads to an improvement of the anthropometric and lipid parameters in obese children following dietary physical intervention.
authors.affiliation: Children's Institute Dr. L. Filip, Podebrady, Czech Republic.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Vasickova
authors.forename: Petr
authors.initials: P
authors.lastname: Stavek
authors.forename: Pavel
authors.initials: P
authors.lastname: Suchanek
mesh_terms: D000886:Anthropometry; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D018592:Cross-Over Studies; D004281:Docosahexaenoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism*; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D015525:Fatty Acids, Omega-3; D008055:Lipids; D004281:Docosahexaenoic Acids; D002097:C-Reactive Protein