title: [Clopidogrel induced thrombotic thrombocytopenic purpura].
abstract: BACKGROUND
  Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder. Drug-induced TTP is uncommon and we report a TTP associated with the use of clopidogrel.
  
  
  METHODS
  We report a 50-year-old man who presented with acute myocardial infarction and received clopidogrel therapy. He developed acute TTP ten days after clopidogrel onset. Imputability of the drug was demonstrated during a reintroduction test. Deficiency of ADAMTS 13 was confirmed and autoantibodies against ADAMTS 13 were detected. Complete remission was obtained after 24 plasma exchange sessions and adjunction of corticosteroids.
  
  
  CONCLUSIONS
  Drug-induced TTP are probably immunologic, as was demonstrated in our patient. Clinicians should be aware of this possible uncommon adverse effect of clopidogrel because prompt therapy is imperative for life saving.
authors.affiliation: Service de médecine interne, hôpital Édouard-Herriot, Lyon 69003 cedex, France. ludovickarkowski@hotmail.fr
authors.forename: L
authors.initials: L
authors.lastname: Karkowski
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: J
authors.initials: J
authors.lastname: Lescampf
authors.forename: B
authors.initials: B
authors.lastname: Coppérré
authors.forename: A
authors.initials: A
authors.lastname: Veyradier
authors.forename: J
authors.initials: J
authors.lastname: Ninet
authors.forename: A
authors.initials: A
authors.lastname: Hot
mesh_terms: D000077144:Clopidogrel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000175:diagnosis*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine