title: Asymmetric hydrogenation of 2- and 2,3-substituted quinoxalines with chiral cationic ruthenium diamine catalysts.
abstract: The enantioselective hydrogenation of 2-alkyl- and 2-aryl-subsituted quinoxalines and 2,3-disubstituted quinoxalines was developed by using the cationic Ru(η(6)-cymene)(monosulfonylated diamine)(BArF) system in high yields with up to 99% ee. The counteranion was found to be critically important for the high enantioselectivity and/or diastereoselectivity.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry and Graduate School, Chinese Academy of Sciences (CAS), Beijing 100190, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Ding
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.forename: Lijin
authors.initials: L
authors.lastname: Xu
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003959:Diamines / Q000737:chemistry*; D006865:Hydrogenation; D009942:Organometallic Compounds / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry
chemical_list: D003959:Diamines; D009942:Organometallic Compounds; D011810:Quinoxalines; D013450:Sulfones; D012428:Ruthenium