title: Neurosarcoidosis: report of 30 cases and a literature survey.
abstract: BACKGROUND
  Neurosarcoidosis accounts for approximately 5% of cases of sarcoidosis.
  
  
  OBJECTIVE
  To determine the frequency of Neurosarcoidosis in our setting and analyze the clinical-radiological findings and evolution of 30 patients consecutively diagnosed.
  
  
  METHODS
  The medical records of patients with a diagnosis of Neurosarcoidosis were reviewed, and data regarding the clinical features, ancillary tests performed, treatment, and outcome were recorded. We revised the literature to summarize and discuss the previous clinical series of Neurosarcoidosis.
  
  
  RESULTS
  It accounted for 6.7% of all cases of sarcoidosis. Seven patients had definite diagnosis and 23 had probable diagnosis. The mean age at onset of Neurosarcoidosis was 48.3 years and 66.7% of patients were women. Neurologic clinical features were the first manifestation of Neurosarcoidosis in 70% of cases. Cranial neuropathy was present in 17 patients and 14 of them had facial palsy. The central nervous system was affected in 10 patients and the peripheral nervous system in 5. Chest disease, the most common extraneurologic manifestation, was present in 20 patients. All patients were treated with corticosteroids, and all those with central nervous system involvement had poor outcome.
  
  
  CONCLUSIONS
  Neurosarcoidosis requires a high degree of suspicion to establish the diagnosis. Central nervous system involvement is associated with a poor prognosis.
authors.affiliation: Department of Neurology, Services of Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain. 32535jgb@comb.cat
authors.forename: J
authors.initials: J
authors.lastname: Gascón-Bayarri
authors.forename: J
authors.initials: J
authors.lastname: Mañá
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Yélamos
authors.forename: O
authors.initials: O
authors.lastname: Murillo
authors.forename: R
authors.initials: R
authors.lastname: Reñé
authors.forename: F
authors.initials: F
authors.lastname: Rubio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D011379:Prognosis; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents