title: The impact of ultraviolet therapy on stratum corneum ceramides and barrier function.
abstract: The ceramide profile as well as the barrier function is known to be deteriorated in atopic eczema and psoriasis, and ultraviolet (UV) light is known to improve the barrier function. The impact of UV light on ceramides, however, is not clarified. The aim of this study was to examine the effect of UV therapy in dermatological patients on ceramides and skin barrier function. We found that UV light treatment does not change the ratio of important stratum corneum lipids, but we confirm earlier findings of decreased susceptibility to irritants after UV- therapy.
authors.affiliation: Department of Dermatology, Roskilde Hospital, Copenhagen University, Roskilde, Denmark. jungersted@gmail.com
authors.forename: Jakob Mutanu
authors.initials: JM
authors.lastname: Jungersted
authors.forename: Julie K
authors.initials: JK
authors.lastname: Høgh
authors.forename: Lars I
authors.initials: LI
authors.lastname: Hellgren
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
authors.forename: Tove
authors.initials: T
authors.lastname: Agner
mesh_terms: D002518:Ceramides / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000528:radiation effects*; D008297:Male; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D014467:Ultraviolet Therapy
chemical_list: D002518:Ceramides