title: Serum metabolic profile in multiple sclerosis patients.
abstract: Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established. Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions. According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric acid undergoes to decrease, increase, or no change under this pathological condition. In this study, we report the serum metabolic profile in terms of purines, pyrimidines, creatinine, malondialdehyde, ascorbic acid, nitrite, and nitrate in a group of 170 MS patients. The results show increase in circulating uric acid and other oxypurines (hypoxanthine and xanthine), as well as in uridine and β-pseudouridine. The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid, demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.
authors.affiliation: Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tavazzi
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Batocchi
authors.forename: Angela Maria
authors.initials: AM
authors.lastname: Amorini
authors.forename: Viviana
authors.initials: V
authors.lastname: Nociti
authors.forename: Serafina
authors.initials: S
authors.lastname: D'Urso
authors.forename: Salvatore
authors.initials: S
authors.lastname: Longo
authors.forename: Stefano
authors.initials: S
authors.lastname: Gullotta
authors.forename: Marika
authors.initials: M
authors.lastname: Picardi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lazzarino
references.citation: J Biol Chem. 2006 Oct 20;281(42):31950-62
references.pmid: 16920708
references.citation: J Chromatogr. 1988 Jul 29;429:255-78
references.pmid: 3062020
references.citation: Subcell Biochem. 2005;38:65-78
references.pmid: 15709473
references.citation: Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):675-80
references.pmid: 9435251
references.citation: Free Radic Res. 2003 Apr;37(4):453-60
references.pmid: 12747740
references.citation: Lipids Health Dis. 2010 Feb 18;9:19
references.pmid: 20163740
references.citation: Anal Biochem. 2003 Nov 1;322(1):51-9
references.pmid: 14705780
references.citation: J Rehabil Med. 2010 Sep;42(8):719-23
references.pmid: 20809053
references.citation: Clin Biochem. 2005 Nov;38(11):997-1008
references.pmid: 16139832
references.citation: Ann Nutr Metab. 1986;30(2):137-42
references.pmid: 2421633
references.citation: Eur Neurol. 1992;32(5):248-52
references.pmid: 1521544
references.citation: Neurosci Lett. 1997 Nov 28;238(1-2):25-8
references.pmid: 9464646
references.citation: Neurol Sci. 2002 Oct;23(4):183-8
references.pmid: 12536287
references.citation: Clin Neurol Neurosurg. 2006 Sep;108(6):527-31
references.pmid: 16202511
references.citation: J Neurol. 2001 Feb;248(2):121-6
references.pmid: 11284129
references.citation: Mult Scler. 2010 May;16(5):549-54
references.pmid: 20194579
references.citation: Free Radic Biol Med. 1992 Nov;13(5):489-98
references.pmid: 1459475
references.citation: Exp Brain Res. 1997 Dec;117(3):411-8
references.pmid: 9438708
references.citation: Cardiol J. 2007;14(6):573-9
references.pmid: 18651524
references.citation: J Neurol Sci. 2005 Apr 15;231(1-2):41-4
references.pmid: 15792819
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 15;851(1-2):257-67
references.pmid: 17324645
references.citation: Clin Biochem. 2009 Jul;42(10-11):1001-6
references.pmid: 19341721
references.citation: Nutr Neurosci. 2003 Jun;6(3):189-96
references.pmid: 12793524
references.citation: J Pharmacol Exp Ther. 2008 Jan;324(1):1-7
references.pmid: 17890445
references.citation: Neurology. 1983 Nov;33(11):1444-52
references.pmid: 6685237
references.citation: Mol Cell Biochem. 1992 Oct 21;116(1-2):193-6
references.pmid: 1480149
references.citation: Neurochem Int. 1984;6(3):393-401
references.pmid: 20488061
references.citation: J Neurol. 2004 Mar;251(3):261-8
references.pmid: 15015004
references.citation: Eur J Neurol. 2002 May;9(3):221-6
references.pmid: 11985629
references.citation: J Neurotrauma. 1999 Oct;16(10):903-13
references.pmid: 10547099
references.citation: J Neurol Sci. 2000 Aug 15;177(2):95-103
references.pmid: 10980305
references.citation: Disabil Rehabil. 2010;32 Suppl 1:S59-67
references.pmid: 20929340
references.citation: Mol Cell Biochem. 2010 Jan;333(1-2):269-77
references.pmid: 19688182
references.citation: J Neural Transm (Vienna). 2007;114(8):1011-5
references.pmid: 17393066
references.citation: Neurology. 2004 Oct 26;63(8):1439-45
references.pmid: 15505162
references.citation: J Neurol. 2009 Oct;256(10):1643-8
references.pmid: 19468784
references.citation: Clin Chem Lab Med. 2009;47(7):848-53
references.pmid: 19496733
references.citation: Mult Scler. 2004 Jun;10(3):281-3
references.pmid: 15222692
references.citation: Cell Death Differ. 2005 Sep;12(9):1202-4
references.pmid: 16094397
references.citation: Cell. 1996 May 3;85(3):299-302
references.pmid: 8616884
references.citation: Arch Biochem Biophys. 2000 Apr 15;376(2):333-7
references.pmid: 10775420
references.citation: J Pathol. 2009 Oct;219(2):193-204
references.pmid: 19591199
references.citation: Clin Biochem. 2005 Jan;38(1):97-100
references.pmid: 15607325
references.citation: Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1363-71
references.pmid: 16910783
references.citation: Ann Neurol. 2006 Mar;59(3):478-89
references.pmid: 16392116
references.citation: Muscle Nerve. 1995 Dec;18(12):1403-11
references.pmid: 7477063
references.citation: Nature. 1999 Jun 24;399(6738 Suppl):A40-7
references.pmid: 10392579
references.citation: Disabil Rehabil. 2006 Sep 30;28(18):1119-26
references.pmid: 16966232
references.citation: J Neurol. 2003 May;250(5):588-92
references.pmid: 12736739
references.citation: Eur J Neurol. 2008 Apr;15(4):394-7
references.pmid: 18312403
references.citation: Mult Scler. 2008 Mar;14(2):188-96
references.pmid: 17942520
references.citation: J Neurol. 2006 Feb;253(2):224-30
references.pmid: 16307201
references.citation: Neurol Res. 2006 Apr;28(3):316-9
references.pmid: 16687059