title: Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH: A Retrospective Study in 32 Children.
abstract: Thirty-two consecutive children aged 0-18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children's University Hospital Brno. The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients. There were no adverse events or increased bleeding reported in any patients. No recurrences were observed during a followup period of 6 months. Although continuous infusion should not replace subcutaneous (SC) administration of LMWH, CI appeared to be safe and efficient and may provide an alternate method of administering LMWH in a subset of the paediatric population where SC administration may not be feasible. Further prospective studies are needed to support the promising findings of our pilot clinical observation.
authors.affiliation: Department of Clinical Haematology, Centre for Thrombosis and Haemostasis. Children's University Hospital, Masaryk University, 62500 Brno, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Fiamoli
authors.forename: Jan
authors.initials: J
authors.lastname: Blatny
authors.forename: Ondrej
authors.initials: O
authors.lastname: Zapletal
authors.forename: Svetlana
authors.initials: S
authors.lastname: Kohlerova
authors.forename: Eva
authors.initials: E
authors.lastname: Janousova
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