title: East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians.
abstract: Prostate cancer is the most prevalent cancer in males in Western countries. The reported incidence in Asia is much lower than that in African Americans and European Caucasians. Although the lack of systematic prostate cancer screening system in Asian countries explains part of the difference, this alone cannot fully explain the lower incidence in Asian immigrants in the United States and west-European countries compared to the black and non-Hispanic white in those countries, nor the somewhat better prognosis in Asian immigrants with prostate cancer in the United States. Soy food consumption, more popular in Asian populations, is associated with a 25% to 30% reduced risk of prostate cancer. Prostate-specific antigen(PSA) is the only established and routinely implemented clinical biomarker for prostate cancer detection and disease status. Other biomarkers, such as urinary prostate cancer antigen 3 RNA, may increase accuracy of prostate cancer screening compared to PSA alone. Several susceptible loci have been identified in genetic linkage analyses in populations of countries in the West, and approximately 30 genetic polymorphisms have been reported to modestly increase the prostate cancer risk in genome-wide association studies. Most of the identified polymorphisms are reproducible regardless of ethnicity. Somatic mutations in the genomes of prostate tumors have been repeatedly reported to include deletion and gain of the 8p and 8q chromosomal regions, respectively; epigenetic gene silencing of glutathione S-transferase Pi(GSTP1); as well as mutations in androgen receptor gene. However, the molecular mechanisms underlying carcinogenesis, aggressiveness, and prognosis of prostate cancer remain largely unknown. Gene-gene and/or gene-environment interactions still need to be learned. In this review, the differences in PSA screening practice, reported incidence and prognosis of prostate cancer, and genetic factors between the populations in East and West factors are discussed.
authors.affiliation: Epidemiology, Janssen Pharmaceutical K.K., Tokyo 101-0065, Japan. tkimura1@its.jnj.com
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D020868:Gene Silencing; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D011110:Polymorphism, Genetic; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D044465:White People / Q000208:ethnology* / Q000235:genetics
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D017430:Prostate-Specific Antigen
references.citation: Cancer Lett. 2011 Feb 1;301(1):1-6
references.pmid: 21093148
references.citation: Cancer Causes Control. 2006 Aug;17(6):803-11
references.pmid: 16783608
references.citation: Hum Mutat. 2004 Jun;23(6):527-33
references.pmid: 15146455
references.citation: Am J Epidemiol. 2009 Apr 15;169(8):937-45
references.pmid: 19240222
references.citation: BJU Int. 2003 Jun;91(9):789-94
references.pmid: 12780833
references.citation: J Immigr Health. 2004 Jan;6(1):41-8
references.pmid: 14762323
references.citation: J Hum Genet. 2004;49(1):9-15
references.pmid: 14666403
references.citation: Cancer Causes Control. 2008 Apr;19(3):227-56
references.pmid: 18066673
references.citation: Eur Urol. 2009 Oct;56(4):584-91
references.pmid: 19660851
references.citation: Jpn J Clin Oncol. 2006 Sep;36(9):602-7
references.pmid: 16870692
references.citation: Prostate Cancer Prostatic Dis. 2011 Sep;14(3):225-31
references.pmid: 21647176
references.citation: Cancer. 2007 Sep 15;110(6):1255-63
references.pmid: 17701951
references.citation: Br J Cancer. 2003 Aug 18;89(4):691-6
references.pmid: 12915880
references.citation: N Engl J Med. 2009 Mar 26;360(13):1320-8
references.pmid: 19297566
references.citation: Zhonghua Yi Xue Za Zhi. 2010 Nov 2;90(40):2811-4
references.pmid: 21162788
references.citation: Med Oncol. 2011 Mar;28(1):357-64
references.pmid: 20077039
references.citation: Cancer. 2003 Apr 15;97(8):1894-903
references.pmid: 12673715
references.citation: Prostate. 2010 Mar 1;70(4):425-32
references.pmid: 19866473
references.citation: Am J Clin Nutr. 2009 Apr;89(4):1155-63
references.pmid: 19211820
references.citation: Prostate. 2010 Feb 1;70(2):170-8
references.pmid: 19760631
references.citation: Cancer. 2002 Feb 15;94(4):1175-82
references.pmid: 11920489
references.citation: Nat Genet. 2010 Sep;42(9):751-4
references.pmid: 20676098
references.citation: Cancer. 2011 Jun 15;117(12):2762-9
references.pmid: 21656755
references.citation: J Urol. 2004 Oct;172(4 Pt 1):1297-301
references.pmid: 15371827
references.citation: Br J Cancer. 2006 Apr 10;94(7):1079-85
references.pmid: 16523198
references.citation: Lancet Oncol. 2010 Aug;11(8):725-32
references.pmid: 20598634
references.citation: N Engl J Med. 2000 Jul 13;343(2):78-85
references.pmid: 10891514
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1285-9
references.pmid: 19318432
references.citation: Prostate. 2010 May 15;70(7):735-44
references.pmid: 20333727
references.citation: Prostate. 2007 May 15;67(7):692-700
references.pmid: 17342750
references.citation: BJU Int. 2008 Nov;102(10):1407-12
references.pmid: 18540931
references.citation: Int J Public Health. 2012 Feb;57(1):57-62
references.pmid: 21681451
references.citation: Eur J Hum Genet. 2008 Apr;16(4):496-505
references.pmid: 18231127
references.citation: BJU Int. 2011 Mar;107(6):882-91
references.pmid: 21392207
references.citation: Int J Urol. 2008 Feb;15(2):156-60; discussion 161
references.pmid: 18269453
references.citation: J Urol. 2003 Sep;170(3):901-4
references.pmid: 12913726
references.citation: PLoS One. 2011 Feb 24;6(2):e17142
references.pmid: 21390317
references.citation: Eur J Cancer. 2010 Sep;46(14):2647-59
references.pmid: 20843493
references.citation: BJU Int. 2006 Jun;97(6):1190-3
references.pmid: 16686710
references.citation: BJU Int. 2009 Dec;104(11):1592-8
references.pmid: 19549125
references.citation: Clin Cancer Res. 2006 Oct 1;12(19):5713-9
references.pmid: 17020975
references.citation: CMAJ. 2006 Mar 14;174(6):787-91
references.pmid: 16534085
references.citation: Acta Oncol. 2011 Jan;50(1):14-24
references.pmid: 20874046
references.citation: Prostate. 2006 Sep 1;66(12):1285-91
references.pmid: 16741923
references.citation: Mol Nutr Food Res. 2009 Feb;53(2):171-84
references.pmid: 19101947
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):538-45
references.pmid: 17337648
references.citation: Eur J Cancer. 2007 Mar;43(5):901-8
references.pmid: 17258450
references.citation: Aging Male. 2010 Mar;13(1):10-7
references.pmid: 19883296
references.citation: Asian J Androl. 2009 Jan;11(1):9-13
references.pmid: 19050685
references.citation: Mt Sinai J Med. 2010 Nov-Dec;77(6):643-54
references.pmid: 21105126
references.citation: Urology. 2009 Sep;74(3):648-53
references.pmid: 19428062
references.citation: Med J Aust. 2011 Mar 21;194(6):293-6
references.pmid: 21426283
references.citation: Am J Public Health. 2003 Oct;93(10):1753-9
references.pmid: 14534233
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2528-39
references.pmid: 19706844
references.citation: Am J Epidemiol. 2010 Jan 1;171(1):1-13
references.pmid: 19914946
references.citation: Jpn J Clin Oncol. 2011 Jan;41(1):40-51
references.pmid: 20819833
references.citation: Exp Mol Pathol. 2011 Feb;90(1):97-100
references.pmid: 20970419
references.citation: Jpn J Clin Oncol. 2011 Jan;41(1):139-47
references.pmid: 20819836
references.citation: MMWR Surveill Summ. 2010 Dec 10;59(10):1-221
references.pmid: 21150869
references.citation: CA Cancer J Clin. 2007 Jul-Aug;57(4):190-205
references.pmid: 17626117
references.citation: Cancer Control. 2009 Apr;16(2):176-85
references.pmid: 19337204
references.citation: Prostate Cancer Prostatic Dis. 2010 Sep;13(3):270-7
references.pmid: 20231859
references.citation: Mol Cell Endocrinol. 2012 Sep 5;360(1-2):25-37
references.pmid: 21782882
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1395-402
references.pmid: 14693728
references.citation: Pathology. 2007 Jun;39(3):299-304
references.pmid: 17558856
references.citation: BMC Public Health. 2009 May 15;9:144
references.pmid: 19442312
references.citation: Nutr Cancer. 2009;61(5):598-606
references.pmid: 19838933
references.citation: Prostate. 2011 Feb 1;71(2):209-24
references.pmid: 20690139
references.citation: BJU Int. 2011 Apr;107(8):1216-22
references.pmid: 21040364
references.citation: J Urol. 2006 Mar;175(3 Pt 1):907-12
references.pmid: 16469577
references.citation: Int J Cancer. 2006 Sep 15;119(6):1447-54
references.pmid: 16596645
references.citation: Int J Cancer. 2003 Dec 10;107(5):797-803
references.pmid: 14566830
references.citation: Int J Cancer. 1994 Sep 1;58(5):638-43
references.pmid: 8077046
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1765-71
references.pmid: 15533905
references.citation: BJU Int. 2011 Nov;108(9):1402-8
references.pmid: 21481132
references.citation: Cancer Causes Control. 2008 Jun;19(5):443-50
references.pmid: 18095173
references.citation: Am J Epidemiol. 2006 Aug 15;164(4):376-84
references.pmid: 16829552
references.citation: Korean J Urol. 2011 Jan;52(1):9-12
references.pmid: 21344024
references.citation: Prostate. 2011 Mar 1;71(4):421-30
references.pmid: 20878950
references.citation: Hum Hered. 2010;69(3):193-201
references.pmid: 20203524
references.citation: Am J Hum Genet. 2005 Aug;77(2):219-29
references.pmid: 15988677
references.citation: Cancer Res. 2010 Jul 1;70(13):5207-12
references.pmid: 20516122