title: Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam.
abstract: Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) were isolated from the ethyl acetate extract of Fissistigma poilanei along with five known compounds: oxocrebanine (3), kuafumine (4), (2R,3R)-3',4',5,7-tetrahydroxydihydroflavonol-3-O-α-L-rhamnopyranoside (5), (+)-catechin 3-O-α-L-rhamnopyranoside (6) and quercetine 3,7-dimethoxy-3'-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (7). These two new aporphine alkaloids exhibited a moderate cytotoxic activity against four human cancer cell lines (KB, Hep-G2, MCF-7, LU) as well as antimicrobial activity against Lactobacillus fermentum, Enterococcus faecium, Staphylococcus aureus and Bacillus subtillis.
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam. tranthithanhthuygl@gmail.com
authors.forename: Tran Thi Thanh
authors.initials: TT
authors.lastname: Thuy
authors.forename: Tran Duc
authors.initials: TD
authors.lastname: Quan
authors.forename: Nguyen Thi Hoang
authors.initials: NT
authors.lastname: Anh
authors.forename: Tran Van
authors.initials: TV
authors.lastname: Sung
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D052197:Limosilactobacillus fermentum / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014744:Vietnam
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001060:Aporphines; C081279:aporphine