title: Immunohistochemical expression of types I and III collagen antibodies in the temporomandibular joint disc of human foetuses.
abstract: The objective was to study the morphology of the articular disc and analyse the immunohistochemical expression of types I and III collagen markers in the temporomandibular joint (TMJ) disc of human foetuses of different gestational ages. Twenty TMJ from human foetuses supplied by Universidade Federal de Uberaba with gestational ages from 17 to 24 weeks were studied. The gestational age of the foetuses was determined by measuring the crown-rump (CR) length. Macroscopically, the foetuses were fixed in 10% formalin solution and dissected by removing the skin and subcutaneous tissue and exposing the deep structures. Immunohistochemical markers of type I and III were used to characterize the existence of collagen fibres. Analysis of the immunohistochemical markers of types I and III collagen revealed the presence of heterotypical fibril networks.
authors.affiliation: Departamento de Morfologia e Genética, Universidade Federal de São Paulo, Brasil.
authors.forename: L O C
authors.initials: LO
authors.lastname: de Moraes
authors.forename: F R
authors.initials: FR
authors.lastname: Lodi
authors.forename: T S
authors.initials: TS
authors.lastname: Gomes
authors.forename: S R
authors.initials: SR
authors.lastname: Marques
authors.forename: C T F
authors.initials: CT
authors.lastname: Oshima
authors.forename: C L P
authors.initials: CL
authors.lastname: Lancellotti
authors.forename: J F
authors.initials: JF
authors.lastname: Rodríguez-Vázquez
authors.forename: J R
authors.initials: JR
authors.lastname: Mérida-Velasco
authors.forename: L G
authors.initials: LG
authors.lastname: Alonso
mesh_terms: D024042:Collagen Type I / Q000096:biosynthesis*; D024043:Collagen Type II / Q000096:biosynthesis*; D005260:Female; D005333:Fetus / Q000166:cytology / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019224:Temporomandibular Joint Disc / Q000166:cytology / Q000196:embryology*
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II
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