title: Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes.
abstract: Cyclometalated platinum(II) complexes [Pt(II)(C^N^N)(C≡NR)](+) (HC^N^N = 6-phenyl-2,2'-bipyridyl) display significant inhibition towards TNF-α stimulated NF-κB-dependent gene transcription at concentrations down to the micromolar range.
authors.affiliation: Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D017671:Platinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D017671:Platinum Compounds; D014409:Tumor Necrosis Factor-alpha; D015082:2,2'-Dipyridyl