title: [Antiphospholipid antibodies in practice].
abstract: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the occurrence of thrombotic or obstetrical events associated with the presence in the serum of patients of antibodies that are associated with thrombosis. For the diagnosis of APS, the presence of either lupus anticoagulant, anticardiolipin or anti-β2-glycoprotein1 antibodies of IgG or IgM isotype is required through laboratory testing. Other autoantibodies such as antiphosphatidylethanolamin or antiphosphatidylserin/prothrombin complex antibodies may be interesting in the diagnosis of APS when common antiphospholipid antibodies are missing. These autoantibodies are still under evaluation for their diagnostic contribution. Despite numerous attempts, the assays that are available for the identification of antiphospholipid antibodies have not been standardized yet, which leads to high variability between reagents and laboratories. Thus, to optimize the biological monitoring of APS syndromes, it is mandatory to have consecutive samples analyzed in the same laboratory.
authors.affiliation: Laboratoire d'immunochimie, centre de référence maladies auto-immunes et systémiques rares lupus et syndrome des anticorps antiphospholipides, groupe hospitalier Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. makoto.miyara@psl.aphp.fr
authors.forename: M
authors.initials: M
authors.lastname: Miyara
authors.forename: M-C
authors.initials: MC
authors.lastname: Diemert
authors.forename: Z
authors.initials: Z
authors.lastname: Amoura
authors.forename: L
authors.initials: L
authors.lastname: Musset
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007155:Immunologic Factors / Q000097:blood*; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013927:Thrombosis / Q000276:immunology*; D053482:beta 2-Glycoprotein I / Q000097:blood
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007155:Immunologic Factors; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I