title: [Osteoprotegerin--a new atherosclerosis marker].
abstract: Studies on bones metabolism regulation mechanisms leaded to discovery of RANKL/OPG/RANK signal system (receptor activator of nuclear factor kappaB ligand/osteoprotegerin/receptor activator of nuclear factor kappaB). It was found that beyond bone metabolism regulation Osteoprotegerin (OPG) is involved in some other processes: apoptosis, regulation of immunological system. Data from numerous studies performed in the last years indicate potential association between OPG and cardiovascular pathology. OPG was identified as atherosclerosis marker. Molecular mechanism by which OPG exerts its atherogenic effect is not fully elucidated.
authors.affiliation: Uniwersytet Medyczny w Poznaniu, Katedra i Klinika Chor6b Wewnetrznych, Zaburzeń Metabolicznych i Nadciśnienia Tetniczego. kasiahen@mailmix.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Hen
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
authors.forename: Danuta
authors.initials: D
authors.lastname: Pupek-Musialik
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D050197:Atherosclerosis / Q000097:blood* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D053244:Osteoprotegerin / Q000097:blood* / Q000276:immunology*
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin