title: The placebo effect: advances from different methodological approaches.
abstract: There is accumulating evidence from different methodological approaches that the placebo effect is a neurobiological phenomenon. Behavioral, psychophysiological, and neuroimaging results have largely contributed to accepting the placebo response as real. A major aspect of recent and future advances in placebo research is to demonstrate linkages between behavior, brain, and bodily responses. This article provides an overview of the processes involved in the formation of placebo responses by combining research findings from behavioral, psychophysiological, and neuroimaging methods. The integration of these different methodological approaches is a key objective, motivating our scientific pursuits toward a placebo research that can inform and guide important future scientific knowledge.
authors.affiliation: Institute of Medical Psychology, Ludwig-Maximilians-University of Munich, D-80336 Munich, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Meissner
authors.forename: Ulrike
authors.initials: U
authors.lastname: Bingel
authors.forename: Luana
authors.initials: L
authors.lastname: Colloca
authors.forename: Tor D
authors.initials: TD
authors.lastname: Wager
authors.forename: Alison
authors.initials: A
authors.lastname: Watson
authors.forename: Magne Arve
authors.initials: MA
authors.lastname: Flaten
mesh_terms: D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D006801:Humans; D009422:Nervous System Diseases / Q000523:psychology / Q000628:therapy; D059906:Neuroimaging; D015990:Placebo Effect; D010919:Placebos / Q000494:pharmacology / Q000627:therapeutic use; D011603:Psychophysiology
chemical_list: D010919:Placebos
references.citation: Lancet Neurol. 2004 Nov;3(11):679-84
references.pmid: 15488461
references.citation: J Neurophysiol. 1999 Oct;82(4):1934-43
references.pmid: 10515983
references.citation: Scand J Psychol. 2009 Dec;50(6):652-9
references.pmid: 19930266
references.citation: Eval Health Prof. 2002 Dec;25(4):410-20
references.pmid: 12449084
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1922-30
references.pmid: 21576150
references.citation: J Psychosom Res. 2005 Feb;58(2):121-7
references.pmid: 15820839
references.citation: Pain. 2005 Jun;115(3):338-347
references.pmid: 15911161
references.citation: Pain. 2010 Mar;148(3):368-374
references.pmid: 19875233
references.citation: N Engl J Med. 2011 Jul 14;365(2):119-26
references.pmid: 21751905
references.citation: Auton Neurosci. 2011 Oct 28;164(1-2):62-6
references.pmid: 21752726
references.citation: Psychopharmacology (Berl). 2011 Jun;215(3):537-48
references.pmid: 21384106
references.citation: J Neurosci. 2005 Nov 9;25(45):10390-402
references.pmid: 16280578
references.citation: Psychopharmacology (Berl). 1999 Jul;145(1):105-12
references.pmid: 10445379
references.citation: Arch Gen Psychiatry. 2008 Feb;65(2):220-31
references.pmid: 18250260
references.citation: Psychosom Med. 2011 Feb-Mar;73(2):193-9
references.pmid: 21217098
references.citation: J Neurosci. 2011 Jan 12;31(2):439-52
references.pmid: 21228154
references.citation: Trends Cogn Sci. 2006 Feb;10(2):59-63
references.pmid: 16406760
references.citation: Psychosom Med. 2008 Sep;70(7):811-8
references.pmid: 18725424
references.citation: Proc Natl Acad Sci U S A. 1979 Jul;76(7):3528-31
references.pmid: 291020
references.citation: Sci Transl Med. 2011 Feb 16;3(70):70ra14
references.pmid: 21325618
references.citation: J Neurosci. 2007 Oct 31;27(44):11934-9
references.pmid: 17978033
references.citation: Pain. 2003 Sep;105(1-2):17-25
references.pmid: 14499416
references.citation: Science. 2004 Feb 20;303(5661):1162-7
references.pmid: 14976306
references.citation: Psychosom Med. 1992 Mar-Apr;54(2):192-216
references.pmid: 1565756
references.citation: Pain. 2008 Jun;136(3):250-261
references.pmid: 17703886
references.citation: BMC Med. 2007 Mar 19;5:3
references.pmid: 17371590
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11056-61
references.pmid: 17578917
references.citation: Neuroimage. 2008 Aug 15;42(2):998-1031
references.pmid: 18579414
references.citation: Neuropsychologia. 2010 Jun;48(7):1958-64
references.pmid: 20331992
references.citation: Science. 2002 Mar 1;295(5560):1737-40
references.pmid: 11834781
references.citation: Pain. 2009 Sep;145(1-2):24-30
references.pmid: 19523766
references.citation: Pain. 2011 Oct;152(10):2405-2412
references.pmid: 21875771
references.citation: Mayo Clin Proc. 1993 Oct;68(10):988-1001
references.pmid: 8412366
references.citation: Cogn Affect Behav Neurosci. 2003 Dec;3(4):255-74
references.pmid: 15040547
references.citation: Neuron. 2008 Sep 25;59(6):1037-50
references.pmid: 18817740
references.citation: Curr Opin Anaesthesiol. 2007 Oct;20(5):435-9
references.pmid: 17873596
references.citation: Neuroimage. 2011 Feb 1;54(3):2237-49
references.pmid: 20932917
references.citation: Am Heart J. 2011 Sep;162(3):507-11
references.pmid: 21884868
references.citation: J Neurosci. 2006 Nov 15;26(46):12014-22
references.pmid: 17108175
references.citation: Am J Physiol Regul Integr Comp Physiol. 2001 Sep;281(3):R683-98
references.pmid: 11506981
references.citation: Psychopharmacology (Berl). 2001 Oct;157(4):373-80
references.pmid: 11605096
references.citation: Psychosom Med. 1972 Jul-Aug;34(4):290-4
references.pmid: 5074954
references.citation: J Neurosci. 2005 Aug 24;25(34):7754-62
references.pmid: 16120776
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1808-17
references.pmid: 21576138
references.citation: J Allergy Clin Immunol. 2007 Jun;119(6):1375-81
references.pmid: 17451796
references.citation: J Neurosci. 2010 Sep 29;30(39):12964-77
references.pmid: 20881115
references.citation: Pain. 2011 Jun;152(6):1233-1237
references.pmid: 21342747
references.citation: Pain. 2008 May;136(1-2):211-8
references.pmid: 18372113
references.citation: Pain. 2010 Dec;151(3):816-824
references.pmid: 20943318
references.citation: Psychosom Med. 1999 Mar-Apr;61(2):250-5
references.pmid: 10204979
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: J Psychosom Res. 2010 Apr;68(4):369-77
references.pmid: 20307704
references.citation: Eur J Pain. 2005 Aug;9(4):463-84
references.pmid: 15979027
references.citation: J Clin Epidemiol. 2005 May;58(5):433-5
references.pmid: 15845328
references.citation: Pain. 2008 Oct 15;139(2):306-314
references.pmid: 18538928
references.citation: Nat Med. 2010 Nov;16(11):1277-83
references.pmid: 20948533
references.citation: Pain. 2010 Nov;151(2):430-439
references.pmid: 20817355
references.citation: J Psychosom Res. 2006 Jul;61(1):81-9
references.pmid: 16813849
references.citation: Pain. 2006 Jan;120(1-2):8-15
references.pmid: 16364549
references.citation: J Abnorm Psychol. 1969 Jun;74(3):363-71
references.pmid: 5805738
references.citation: Science. 2009 Oct 16;326(5951):404
references.pmid: 19833962
references.citation: Am Psychol. 1988 Mar;43(3):151-60
references.pmid: 3364852
references.citation: Neurophysiol Clin. 2003 Dec;33(6):279-92
references.pmid: 14678842
references.citation: Pain. 2009 Jul;144(1-2):28-34
references.pmid: 19278785
references.citation: J Neurosci. 2006 Jan 11;26(2):559-63
references.pmid: 16407554
references.citation: Pain. 2007 Jan;127(1-2):63-72
references.pmid: 16963184
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1799-807
references.pmid: 21576137
references.citation: Br J Clin Psychol. 1986 Sep;25 ( Pt 3):173-83
references.pmid: 3768575
references.citation: Nat Neurosci. 2004 Jun;7(6):587-8
references.pmid: 15146189
references.citation: J Neurosci. 1999 Jan 1;19(1):484-94
references.pmid: 9870976
references.citation: J Psychosom Res. 2009 May;66(5):391-8
references.pmid: 19379955
references.citation: FASEB J. 2002 Dec;16(14):1869-73
references.pmid: 12468450
references.citation: Pain. 2007 Jul;130(1-2):137-43
references.pmid: 17215080
references.citation: Pain. 2006 Sep;124(1-2):126-33
references.pmid: 16701952
references.citation: Lancet. 1978 Sep 23;2(8091):654-7
references.pmid: 80579
references.citation: Nat Rev Neurosci. 2005 Jul;6(7):545-52
references.pmid: 15995725
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1818-27
references.pmid: 21576139
references.citation: Psychosom Med. 2003 Sep-Oct;65(5):786-90
references.pmid: 14508021
references.citation: Pain. 2006 Mar;121(1-2):133-44
references.pmid: 16473462
references.citation: Neuroimage. 2009 Sep;47(3):1135-40
references.pmid: 19524045
references.citation: FASEB J. 2009 Apr;23(4):1161-7
references.pmid: 19103649
references.citation: Brain Res. 2010 Nov 4;1359:137-41
references.pmid: 20735999
references.citation: J Pain Res. 2011 Mar 24;4:79-83
references.pmid: 21559353
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1859-69
references.pmid: 21576143
references.citation: Learn Behav. 2008 Aug;36(3):242-52
references.pmid: 18683468
references.citation: J Neurosci. 2006 Jan 11;26(2):381-8
references.pmid: 16407533
references.citation: J Pain. 2010 Nov;11(11):1165-71
references.pmid: 20627818
references.citation: Nat Rev Neurosci. 2011 Mar;12(3):154-67
references.pmid: 21331082
references.citation: J Neurosci. 1999 May 1;19(9):3639-48
references.pmid: 10212322
references.citation: Neuron. 2009 Aug 27;63(4):533-43
references.pmid: 19709634