title: Adult urologic sarcoma: experience during 2 decades.
abstract: OBJECTIVE
  To identify factors associated with long-term outcome and to report possibly meaningful clinical features in a unicentric sample of adult urologic sarcomas.
  
  
  METHODS
  Thirty-five patients treated between 1992 and 2011 were studied. Except for 3 patients, surgery was the initial treatment. The median follow-up in the surviving (censored) patients was 11.3 years. Kaplan-Meier method and competing risk analysis were used to evaluate outcome. Disease recurrence, disease-specific mortality, and overall mortality were the study endpoints. Comparisons were made with the log rank and the Pepe-Mori tests. Cox proportional hazard models were used to identify independent predictors of disease recurrence.
  
  
  RESULTS
  Only disease grade was significantly associated with all 3 study endpoints. The primary tumor site was significantly associated with disease-specific and recurrence-free survival but did not reach the significance level concerning overall survival. In the multivariate analysis, primary site and tumor grade were identified as predictors of disease recurrence. Whereas 10-year disease-specific survival was 100% in patients with low grade inguinoscrotal tumors, it was 0% in patients with high grade disease arising from other sites.
  
  
  CONCLUSIONS
  Low grade and inguinoscrotal origin are factors associated with favorable outcome in urologic sarcomas. Repeat interventions to remove or to inactivate recurrent tumors or metastases seem to provide clinical benefit in individual cases.
authors.affiliation: Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany. Electronic address: Michael.Froehner@uniklinikum-dresden.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Froehner
authors.forename: Rebecca R
authors.initials: RR
authors.lastname: Schober
authors.forename: Rainer
authors.initials: R
authors.lastname: Koch
authors.forename: Arndt
authors.initials: A
authors.lastname: Lossnitzer
authors.forename: Michael
authors.initials: M
authors.lastname: Laniado
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Wirth
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D014571:Urologic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*