title: Role of leptin and its receptors in the pathogenesis of thyroid cancer.
abstract: Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.
authors.affiliation: Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia. Shahab@kfshrc.edu.sa
authors.forename: Shahab
authors.initials: S
authors.lastname: Uddin
authors.forename: Azhar R
authors.initials: AR
authors.lastname: Hussain
authors.forename: Abdul K
authors.initials: AK
authors.lastname: Siraj
authors.forename: Omar S
authors.initials: OS
authors.lastname: Khan
authors.forename: Prashant P
authors.initials: PP
authors.lastname: Bavi
authors.forename: Khawla S
authors.initials: KS
authors.lastname: Al-Kuraya
mesh_terms: D006801:Humans; D020738:Leptin / Q000378:metabolism*; D054411:Receptors, Leptin / Q000378:metabolism*; D015398:Signal Transduction; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin
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