title: Blood pressure and TNF-α act synergistically to increase leucocyte CD11b adhesion molecule expression in the BELFAST study: implications for better blood pressure control in ageing.
abstract: Hypertension, a key risk factor for stroke, cardiovascular disease and dementia, is associated with chronic vascular inflammation, and although poorly understood, putative mechanisms include pro-inflammatory responses induced by mechanical stretching, with cytokine release and associated up-regulated expression of adhesion molecules. Because blood pressure increases with age, we measured baseline and tumour necrosis alpha (TNF-α)-stimulated CD11b/CD18 adhesion molecule expression on leucocytes to assess any association between the two. In 38 subjects (mean age 85 years), consecutively enrolled from Belfast Elderly Longitudinal Free-Living Aging Study (BELFAST), baseline and TNF-α-stimulated CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure >120 mmHg (p = 0.05) and for lymphocytes, with diastolic blood pressure >80 mmHg (p < 0.05).These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-α, and suggest mechanistic reasons why better hypertension control is important.
authors.affiliation: Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast 9, UK. i.rea@qub.ac.uk
authors.forename: I Maeve
authors.initials: IM
authors.lastname: Rea
authors.forename: Susan E
authors.initials: SE
authors.lastname: McNerlan
authors.forename: Denis H
authors.initials: DH
authors.lastname: Alexander
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Armstrong
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000592:standards*; D039481:CD11b Antigen / Q000096:biosynthesis*; D002448:Cell Adhesion / Q000187:drug effects; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D039481:CD11b Antigen; C509295:ITGAM protein, human; D014409:Tumor Necrosis Factor-alpha
references.citation: Chem Biol Interact. 2010 Apr 29;185(2):137-42
references.pmid: 20223228
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: J Hypertens. 2006 Sep;24(9):1891-8
references.pmid: 16915040
references.citation: BMJ. 2008 Jul 08;337:a399
references.pmid: 18614506
references.citation: Hypertension. 1999 Sep;34(3):466-71
references.pmid: 10489395
references.citation: J Biol Chem. 2004 Mar 26;279(13):12001-4
references.pmid: 14960578
references.citation: FASEB J. 1994 May;8(8):504-12
references.pmid: 8181668
references.citation: Biochemistry. 2002 Oct 29;41(43):12995-3002
references.pmid: 12390026
references.citation: N Engl J Med. 2008 May 1;358(18):1887-98
references.pmid: 18378519
references.citation: JAMA. 2011 Mar 2;305(9):913-22
references.pmid: 21364140
references.citation: Arch Intern Med. 1997 Nov 24;157(21):2413-46
references.pmid: 9385294
references.citation: J Gen Intern Med. 2000 Oct;15(10):702-9
references.pmid: 11089713
references.citation: Lancet. 2008 May 3;371(9623):1513-8
references.pmid: 18456100
references.citation: BMJ. 2011 Jun 24;342:d3621
references.pmid: 21705406
references.citation: Lancet. 1995 Dec 23-30;346(8991-8992):1647-53
references.pmid: 8551820
references.citation: Gerontology. 2001 Jul-Aug;47(4):180-5
references.pmid: 11408721
references.citation: Hypertension. 2007 Dec;50(6):1026-32
references.pmid: 18025294
references.citation: Circulation. 1995 Apr 1;91(7):1914-7
references.pmid: 7534663
references.citation: Mech Ageing Dev. 1984 Nov;28(1):47-55
references.pmid: 6513613
references.citation: J Rheumatol. 2005 Jul;32(7):1213-8
references.pmid: 15996054
references.citation: Am J Epidemiol. 2008 Dec 15;168(12):1444-51
references.pmid: 18953059
references.citation: Am J Hypertens. 2006 Jul;19(7):713-7
references.pmid: 16814126
references.citation: Nutr Res Pract. 2007 Winter;1(4):285-90
references.pmid: 20368952
references.citation: J Lab Clin Med. 1997 Mar;129(3):300-8
references.pmid: 9042815
references.citation: Curr Pharm Des. 2010;16(7):789-95
references.pmid: 20388089
references.citation: Circ Res. 2007 Apr 27;100(8):1226-33
references.pmid: 17395876
references.citation: N Engl J Med. 2001 Aug 16;345(7):479-86
references.pmid: 11519501
references.citation: JAMA. 1991 Jun 26;265(24):3255-64
references.pmid: 2046107
references.citation: JAMA. 2008 Dec 3;300(21):2545-7
references.pmid: 19050198
references.citation: Am J Hypertens. 2001 Jun;14(6 Pt 2):44S-54S
references.pmid: 11411765
references.citation: J Cardiovasc Pharmacol. 2004 Apr;43(4):514-21
references.pmid: 15085062
references.citation: Lancet. 2002 Dec 14;360(9349):1903-13
references.pmid: 12493255
references.citation: Age (Dordr). 2009 Dec;31(4):261-7
references.pmid: 19496022
references.citation: Hypertension. 1996 Sep;28(3):386-91
references.pmid: 8794821
references.citation: JAMA. 2003 May 21;289(19):2560-72
references.pmid: 12748199
references.citation: J Cell Biol. 2005 Apr 11;169(1):191-202
references.pmid: 15809308
references.citation: FASEB J. 2001 Aug;15(10):1822-4
references.pmid: 11481242
references.citation: Eur Heart J. 2002 Feb;23(4):286-93
references.pmid: 11812064
references.citation: Hypertension. 1999 Jul;34(1):113-7
references.pmid: 10406833
references.citation: Blood Press Monit. 1999 Dec;4(6):319-31
references.pmid: 10602536
references.citation: Haematologica. 1995 Mar-Apr;80(2):161-75
references.pmid: 7628754
references.citation: Eur J Clin Nutr. 1997 Feb;51(2):102-6
references.pmid: 9049569