title: Serum bilirubin level is negatively correlated with disease progression of peripheral arterial disease: an observational cohort study.
abstract: We determined whether low bilirubin level is a risk factor for peripheral arterial disease (PAD). We recruited 318 patients with PAD and 100 healthy volunteers. Patients were divided into 4 groups by the Fontaine classification for PAD, namely, group 1 (grade 1, n = 4); group 2 (grade 2, n = 114), group 3 (grade 3, n = 164), and group 4 (grade 4, n = 36). Total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL) levels were compared using stepwise multiple regressions adjusted for selected factors. After adjusting for gender, age, smoking, and diastolic blood pressure, serum levels of T-BIL, D-BIL, and I-BIL were significantly lower in the PAD group (P < .05). Patients with grade 4 PAD showed significantly (P < .05) lower levels of T-BIL when compared with grade 2 patients. We concluded that serum bilirubin levels are negatively correlated with the severity and progression of PAD.
authors.affiliation: Department of General Surgery, the First Affiliated hospital of Harbin Medical University, Harbin, HeiLongjiang, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Han
authors.forename: Wei-Hui
authors.initials: WH
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Ha-Li
authors.initials: HL
authors.lastname: Li
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Ren-Ping
authors.initials: RP
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D019370:Observation; D058729:Peripheral Arterial Disease / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001663:Bilirubin