title: [Reduced synthesis of coenzyme Q10 may cause statin related myopathy].
abstract: Statin treatment can cause muscular side effects. It has been suggested that the mechanism is reduced synthesis of coenzyme Q10 (coQ10) and a subsequent dysfunction of the respiratory chain. A literature review resulted in insufficient evidence supporting this theory. It is uncertain whether intramuscular levels of coQ10 and mitochondrial function are affected by statin therapy and whether the symptoms of myopathy can be alleviated with coQ10 supplementation. Nevertheless, due to a favourable safety profile, coQ10 can be tested in patients whose muscular symptoms cannot be managed otherwise.
authors.affiliation: Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, København, Denmark. mettelundgren@gmail.com
authors.forename: Mette Lundgren
authors.initials: ML
authors.lastname: Nielsen
authors.forename: Manan
authors.initials: M
authors.lastname: Pareek
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Henriksen
mesh_terms: D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009135:Muscular Diseases / Q000139:chemically induced* / Q000188:drug therapy; D012307:Risk Factors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; C024989:coenzyme Q10