title: Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families.
abstract: BACKGROUND
  To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein-Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan.
  
  
  METHODS
  Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity.
  
  
  RESULTS
  Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31-50 years of age (vs <30, adjusted ORs 0.51-0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender.
  
  
  CONCLUSIONS
  Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., EPS 7073, Rockville, MD, USA. changcm@mail.nih.gov
authors.forename: C M
authors.initials: CM
authors.lastname: Chang
authors.forename: K J
authors.initials: KJ
authors.lastname: Yu
authors.forename: W L
authors.initials: WL
authors.lastname: Hsu
authors.forename: J M
authors.initials: JM
authors.lastname: Major
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: P J
authors.initials: PJ
authors.lastname: Lou
authors.forename: M Y
authors.initials: MY
authors.lastname: Liu
authors.forename: S R
authors.initials: SR
authors.lastname: Diehl
authors.forename: A M
authors.initials: AM
authors.lastname: Goldstein
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Hildesheim
mesh_terms: D000293:Adolescent; D000328:Adult; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology*; D005190:Family; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D007070:Immunoglobulin A; C417029:EBV-encoded nuclear antigen 1
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