title: CNTRICS imaging biomarkers final task selection: Long-term memory and reinforcement learning.
abstract: Functional imaging paradigms hold great promise as biomarkers for schizophrenia research as they can detect altered neural activity associated with the cognitive and emotional processing deficits that are so disabling to this patient population. In an attempt to identify the most promising functional imaging biomarkers for research on long-term memory (LTM), the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative selected "item encoding and retrieval," "relational encoding and retrieval," and "reinforcement learning" as key LTM constructs to guide the nomination process. This manuscript reports on the outcome of the third CNTRICS biomarkers meeting in which nominated paradigms in each of these domains were discussed by a review panel to arrive at a consensus on which of the nominated paradigms could be recommended for immediate translational development. After briefly describing this decision process, information is presented from the nominating authors describing the 4 functional imaging paradigms that were selected for immediate development. In addition to describing the tasks, information is provided on cognitive and neural construct validity, sensitivity to behavioral or pharmacological manipulations, availability of animal models, psychometric characteristics, effects of schizophrenia, and avenues for future development.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California at Davis Imaging Research Center, Sacramento, CA 95817, USA. jdragland@ucdavis.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Ragland
authors.forename: Neal J
authors.initials: NJ
authors.lastname: Cohen
authors.forename: Roshan
authors.initials: R
authors.lastname: Cools
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Frank
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Hannula
authors.forename: Charan
authors.initials: C
authors.lastname: Ranganath
mesh_terms: D015415:Biomarkers; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D057567:Memory, Long-Term / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D011594:Psychometrics / Q000295:instrumentation; D012054:Reinforcement, Psychology; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*
chemical_list: D015415:Biomarkers
references.citation: Front Hum Neurosci. 2010 Oct 08;4:166
references.pmid: 21151363
references.citation: Science. 2006 Feb 10;311(5762):861-3
references.pmid: 16469930
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16311-6
references.pmid: 17913879
references.citation: J Cogn Neurosci. 2007 Oct;19(10):1690-705
references.pmid: 17854282
references.citation: Biol Psychiatry. 2010 Oct 1;68(7):617-24
references.pmid: 20655509
references.citation: Neuroscientist. 2007 Jun;13(3):280-91
references.pmid: 17519370
references.citation: J Neurosci. 2006 May 17;26(20):5360-9
references.pmid: 16707788
references.citation: Neuropsychopharmacology. 2007 Jan;32(1):180-9
references.pmid: 16841074
references.citation: Schizophr Bull. 2012 Jan;38(1):114-24
references.pmid: 22124089
references.citation: Neuron. 2009 Sep 10;63(5):592-9
references.pmid: 19755103
references.citation: Arch Gen Psychiatry. 2006 Jun;63(6):611-21
references.pmid: 16754834
references.citation: J Cogn Neurosci. 2008 Aug;20(8):1478-89
references.pmid: 18303974
references.citation: J Neurosci. 2011 Feb 2;31(5):1606-13
references.pmid: 21289169
references.citation: Nat Neurosci. 2011 Sep 25;14(11):1462-7
references.pmid: 21946325
references.citation: J Neurosci. 2008 Oct 22;28(43):10972-82
references.pmid: 18945905
references.citation: J Cogn Neurosci. 2004 Apr;16(3):463-78
references.pmid: 15072681
references.citation: Biol Psychiatry. 2008 Jul 1;64(1):18-25
references.pmid: 18495087
references.citation: Neuropsychology. 2009 Sep;23(5):571-80
references.pmid: 19702411
references.citation: Dev Sci. 2009 Jul;12(4):549-56
references.pmid: 19635082
references.citation: Biol Psychiatry. 2011 Jul 1;70(1):7-12
references.pmid: 21529781
references.citation: Neuropsychopharmacology. 2010 May;35(6):1290-301
references.pmid: 20107431
references.citation: J Neurosci. 2002 Jun 1;22(11):4563-7
references.pmid: 12040063
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19179-84
references.pmid: 19850878
references.citation: Brain. 1999 Aug;122 ( Pt 8):1469-93
references.pmid: 10430832
references.citation: Science. 2007 Nov 23;318(5854):1309-12
references.pmid: 17962524
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2157-62
references.pmid: 12578977
references.citation: Science. 2004 Apr 16;304(5669):452-4
references.pmid: 15087550
references.citation: J Neurosci. 2009 Apr 15;29(15):4690-6
references.pmid: 19369539
references.citation: J Cogn Neurosci. 2006 Nov;18(11):1863-76
references.pmid: 17069477
references.citation: Behav Brain Res. 1989 Jan 1;31(3):231-42
references.pmid: 2914074
references.citation: Cereb Cortex. 2001 Dec;11(12):1136-43
references.pmid: 11709484
references.citation: Am J Psychiatry. 2005 Oct;162(10):1840-8
references.pmid: 16199830
references.citation: Psychol Med. 2005 Jul;35(7):1031-41
references.pmid: 16045069
references.citation: Psychopharmacology (Berl). 2001 Dec;159(1):10-20
references.pmid: 11797064
references.citation: Behav Neurosci. 2006 Jun;120(3):497-517
references.pmid: 16768602
references.citation: Neuron. 2008 Oct 23;60(2):378-89
references.pmid: 18957228
references.citation: J Neurosci. 2007 May 16;27(20):5515-22
references.pmid: 17507573
references.citation: Biol Psychiatry. 2007 Oct 1;62(7):756-64
references.pmid: 17300757
references.citation: Genes Brain Behav. 2007 Jun;6(4):314-20
references.pmid: 16848782
references.citation: Neuroimage. 2010 Feb 15;49(4):3198-209
references.pmid: 19969093
references.citation: Neuropsychopharmacology. 2007 Jul;32(7):1583-99
references.pmid: 17164816
references.citation: Science. 2004 Dec 10;306(5703):1940-3
references.pmid: 15528409
references.citation: Cortex. 1991 Dec;27(4):613-22
references.pmid: 1782795
references.citation: Brain Res. 2010 Mar 4;1317:180-91
references.pmid: 20051237
references.citation: J Neurosci. 2008 Jun 4;28(23):5976-82
references.pmid: 18524902
references.citation: Neuropsychologia. 1999 Nov;37(12):1359-74
references.pmid: 10606011
references.citation: Schizophr Res. 2007 Jul;93(1-3):296-303
references.pmid: 17482797
references.citation: J Neurosci. 2010 Jan 20;30(3):930-8
references.pmid: 20089901