title: Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents.
abstract: The incidence of asthma and atopic dermatitis (AD) was evaluated in HIV-infected (n = 451) compared to HIV-exposed (n = 227) but uninfected (HEU) children and adolescents by abstraction from clinical charts. Asthma was more common in HIV-infected compared to HEU children by clinical diagnosis (25% vs. 20%, p = 0.101), by asthma medication use, (31% vs. 22%, p = 0.012), and by clinical diagnosis and/or medication use, (34% vs. 25%, p = 0.012). HIV-infected children had a greater risk of asthma compared to HEU children (HR = 1.37, 95% CI: 1.01 to 1.86). AD was more common in HIV-infected than HEU children (20% vs. 12%, p = 0.009)) and children with AD were more likely to have asthma in both cohorts (41% vs. 29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide.
authors.affiliation: Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: George K
authors.initials: GK
authors.lastname: Siberry
authors.forename: Erin
authors.initials: E
authors.lastname: Leister
authors.forename: Denise L
authors.initials: DL
authors.lastname: Jacobson
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Foster
authors.forename: George R
authors.initials: GR
authors.lastname: Seage
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lipshultz
authors.forename: Mary E
authors.initials: ME
authors.lastname: Paul
authors.forename: Murli
authors.initials: M
authors.lastname: Purswani
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Colin
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Scott
authors.forename: William T
authors.initials: WT
authors.lastname: Shearer
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D004198:Disease Susceptibility; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012307:Risk Factors
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