title: Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial.
abstract: This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a dietary supplement (tablet form) providing 1.8 g/day free (non-esterified) plant sterols and stanols versus placebo for 6 weeks as part of a therapeutic lifestyle changes (TLC) diet in 32 men and women with primary hypercholesterolaemia. Mean ± SE baseline (end of a 5-week TLC diet lead-in) lipid concentrations (mmol/l) were total cholesterol (TC), 5.88 ± 0.08; non-high-density lipoprotein cholesterol (non-HDL-C), 4.71 ± 0.09; low-density lipoprotein cholesterol (LDL-C), 4.02 ± 0.08; HDL-C, 1.17 ± 0.06 and triglycerides (TGs), 1.51 ± 0.12. Differences from control in responses (plant sterol/stanol - control) were significant (p < 0.05) for LDL-C ( - 4.9%), non-HDL-C ( - 3.6%) and TC ( - 2.8%). HDL-C and TG responses were not significantly different between treatment conditions. These results indicate that 1.8 g/day free plant sterols/stanols administered in a tablet produced favourable lipoprotein lipid changes in men and women with hypercholesterolaemia.
authors.affiliation: Provident Clinical Research/Biofortis North America, 489 Taft Avenue, Glen Ellyn, IL 60137, USA. kmaki@providentcrc.com
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Lawless
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Reeves
authors.forename: Mary R
authors.initials: MR
authors.lastname: Dicklin
authors.forename: Belinda H
authors.initials: BH
authors.lastname: Jenks
authors.forename: Ed
authors.initials: E
authors.lastname: Shneyvas
authors.forename: James R
authors.initials: JR
authors.lastname: Brooks
mesh_terms: D002784:Cholesterol / Q000097:blood*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
chemical_list: D010840:Phytosterols; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
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