title: Metastases to the oral region from pleural mesothelioma: Clinicopathologic review.
abstract: BACKGROUND
  Malignant mesothelioma is a rare neoplasm that usually develops after exposure to asbestos and particularly involves the pleural cavity. It has a poor prognosis with aggressive local invasion and metastatic spread.
  
  
  METHODS
  The literature relating to malignant mesothelioma metastatic to the oral region was reviewed.
  
  
  RESULTS
  In all, 14 cases of malignant mesothelioma metastatic to the oral cavity were found. All were from pleural mesotheliomas, the tongue was the most common site of metastasis (8/14), and most metastases (9/13) were of the epithelioid type. The newly reported case is only the second report of a mesothelioma metastasizing to the buccal mucosa. It showed strong immunopositivity for keratin markers, vimentin, calretinin, and Wilms tumor product-1.
  
  
  CONCLUSIONS
  The incidence of mesothelioma is predicted to continue to increase for at least another decade. Clinicians and pathologists should be aware of this lesion and its propensity to metastasize to the oral cavity.
authors.affiliation: MedLab Dental Oral Pathology Diagnostic Service and the Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
authors.forename: Suraya H
authors.initials: SH
authors.lastname: Sinon
authors.forename: Alison M
authors.initials: AM
authors.lastname: Rich
authors.forename: Haizal M
authors.initials: HM
authors.lastname: Hussaini
authors.forename: Han-Seung
authors.initials: HS
authors.lastname: Yoon
authors.forename: Norman A
authors.initials: NA
authors.lastname: Firth
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Seymour
mesh_terms: D006801:Humans; D008654:Mesothelioma / Q000150:complications / Q000556:secondary*; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000556:secondary*; D009362:Neoplasm Metastasis; D010997:Pleural Neoplasms / Q000150:complications / Q000473:pathology*