title: MiR-146a in Immunity and Disease.
abstract: MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR-146a in innate and adaptive immune responses, as well as in disease.
authors.affiliation: Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
authors.forename: Nicole
authors.initials: N
authors.lastname: Rusca
authors.forename: Silvia
authors.initials: S
authors.lastname: Monticelli
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