title: Composite PLA scaffolds reinforced with PDO fibers for tissue engineering.
abstract: Novel composite scaffolds were produced using long continuous bidirectional fibers embedded in an electrospun matrix, with the aim of using them in soft tissue engineering applications. The fibers are of polydioxanone and the matrix of polylactic acid. The novel manufacturing method consists of direct electrospinning performed on both sides of a collector that supports the already arranged fibers. The scaffolds were tested in vitro using 3T3 mouse fibroblasts as-obtained or functionalized with biotin or poly (dopamine). Functionalization did not significantly affect cells attachment, metabolic activity, or proliferation, but poly (dopamine) was proven to be effective in inducing hydrophilicity to the surface.
authors.affiliation: Department of Materials Science and Technology, Faculty of Materials and Environment Engineering, Technical University of Cluj-Napoca, Romania. Liana.Cont@stm.utcluj.ro
authors.forename: Liana
authors.initials: L
authors.lastname: Cont
authors.forename: David
authors.initials: D
authors.lastname: Grant
authors.forename: Colin
authors.initials: C
authors.lastname: Scotchford
authors.forename: Milica
authors.initials: M
authors.lastname: Todea
authors.forename: Catalin
authors.initials: C
authors.lastname: Popa
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion; D049109:Cell Proliferation; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D016687:Polydioxanone / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D016687:Polydioxanone; D019344:Lactic Acid; C033616:poly(lactide)