title: [Effects of Ginkgo biloba extract on anticoagulation and blood drug level of warfarin in healthy wolunteers].
abstract: OBJECTIVE
  To study the effects of Ginkgo biloba extract (GBE) on the pharmacokinetics and pharmacodynamics of warfarin and observe the anticoagulant activity of GBE.
  
  
  METHODS
  A randomized, double-blinded, placebo-controlled, two-way cross-over trial was conducted. Twelve healthy volunteers (sex ratio was 1: 1) were randomized into two groups and received GBE (three pill, tid) or placebo (three pill, tid) for 5 weeks respectively. the subjects received a single dose of warfarin (5 mg) on the day 29. Blood samples for pharmacokinetics and pharmacodynamics assessment were collectd.
  
  
  RESULTS
  Compared with placebo, BE had no significant pharmacodynamics effects on warfarin and had no effects on prothrombin time (PT) and activated partial thromboplastin time (APTT). GBE extract increased C(max), AUC(0-144 min), AUC(0-infinity), t1/2, of warfarin significantly and decreased CL(F) of warfarin significantly (P < 0.05), and there were no singnificant difference of V(d) (F).
  
  
  CONCLUSIONS
  GBE has limited effects on the pharmacokinetics but no effects on the pharmacodynamics of single dose warfain in health subjects. GBE has no effects on clotting process alone.
authors.affiliation: The Third Xiangya Hospital of Central South University, Changsha 410013, China. yulu0027@126.com
authors.forename: Yulu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Rong
authors.initials: R
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D020441:Ginkgo biloba; D041743:Herb-Drug Interactions; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D010936:Plant Extracts; D014859:Warfarin