title: Programmed necrosis: backup to and competitor with apoptosis in the immune system.
abstract: Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. jhan@xmu.edu.cn
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
authors.forename: Chuan-Qi
authors.initials: CQ
authors.lastname: Zhong
authors.forename: Duan-Wu
authors.initials: DW
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D009336:Necrosis / Q000276:immunology*; D015398:Signal Transduction
references.citation: J Bone Joint Surg Br. 2000 May;82(4):601-13
references.pmid: 10855892
references.citation: Brain Res. 2010 Jul 9;1343:206-12
references.pmid: 20451505
references.citation: Eur J Immunol. 2007 Nov;37 Suppl 1:S61-70
references.pmid: 17972347
references.citation: J Biol Chem. 2010 Mar 26;285(13):9535-9544
references.pmid: 20042608
references.citation: Semin Immunopathol. 2007 Sep;29(3):213-29
references.pmid: 17703304
references.citation: J Biol Chem. 2005 Nov 4;280(44):36560-6
references.pmid: 16115877
references.citation: Mol Cell. 2006 Apr 21;22(2):245-57
references.pmid: 16603398
references.citation: Nat Immunol. 2003 May;4(5):410-5
references.pmid: 12719730
references.citation: Mol Cell Biol. 2001 Dec;21(24):8276-88
references.pmid: 11713265
references.citation: J Immunol. 2004 Sep 1;173(5):2976-84
references.pmid: 15322156
references.citation: Cell Host Microbe. 2010 Apr 22;7(4):302-313
references.pmid: 20413098
references.citation: Infect Immun. 2005 Jan;73(1):504-13
references.pmid: 15618190
references.citation: Nat Immunol. 2004 May;5(5):503-7
references.pmid: 15064760
references.citation: FEBS Lett. 2005 Jun 13;579(15):3287-96
references.pmid: 15943973
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16677-82
references.pmid: 18946037
references.citation: Oncogene. 2008 Oct 27;27(50):6434-51
references.pmid: 18955971
references.citation: J Immunol. 2008 Nov 1;181(9):6427-34
references.pmid: 18941233
references.citation: Mol Cell Biol. 2007 Jul;27(13):4844-62
references.pmid: 17470554
references.citation: Nature. 2011 Sep 14;477(7364):335-9
references.pmid: 21921917
references.citation: Nature. 2007 Jul 26;448(7152):501-5
references.pmid: 17618271
references.citation: Science. 2002 Jul 12;297(5579):259-63
references.pmid: 12114629
references.citation: J Immunol. 2005 Apr 15;174(8):4942-52
references.pmid: 15814722
references.citation: Nature. 2011 Mar 17;471(7338):373-6
references.pmid: 21368761
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21695-700
references.pmid: 21098270
references.citation: Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):439-52
references.pmid: 21697901
references.citation: Immunity. 2011 Mar 25;34(3):340-51
references.pmid: 21419663
references.citation: Cell. 2009 Jun 12;137(6):1100-11
references.pmid: 19524512
references.citation: Genes Dev. 1999 Oct 1;13(19):2514-26
references.pmid: 10521396
references.citation: Nat Immunol. 2000 Dec;1(6):489-95
references.pmid: 11101870
references.citation: J Immunol. 2006 Jun 1;176(11):6852-61
references.pmid: 16709845
references.citation: Cell. 2008 May 16;133(4):693-703
references.pmid: 18485876
references.citation: Eur J Biochem. 1991 Jan 30;195(2):465-75
references.pmid: 1847684
references.citation: Infect Immun. 2000 Mar;68(3):1289-96
references.pmid: 10678940
references.citation: J Exp Med. 2009 Sep 28;206(10):2161-77
references.pmid: 19720838
references.citation: J Exp Med. 2004 Aug 16;200(4):425-35
references.pmid: 15314073
references.citation: J Neurosci. 2007 Aug 29;27(35):9278-93
references.pmid: 17728442
references.citation: Nature. 2011 Mar 17;471(7338):368-72
references.pmid: 21368762
references.citation: Mol Cell Biol. 2011 Sep;31(18):3745-58
references.pmid: 21746883
references.citation: Cell Death Differ. 2002 Sep;9(9):981-94
references.pmid: 12181749
references.citation: Cell. 2008 Dec 26;135(7):1311-23
references.pmid: 19109899
references.citation: Cell Mol Immunol. 2010 Jul;7(4):243-9
references.pmid: 20383176
references.citation: Prog Neurobiol. 2009 Dec;89(4):343-58
references.pmid: 19772886
references.citation: Mol Biol Cell. 2002 Mar;13(3):978-88
references.pmid: 11907276
references.citation: Cell. 2003 Jul 25;114(2):181-90
references.pmid: 12887920
references.citation: J Immunol. 2005 Sep 15;175(6):3469-73
references.pmid: 16148088
references.citation: EMBO Rep. 2009 Aug;10(8):916-22
references.pmid: 19590578
references.citation: Annu Rev Immunol. 2008;26:389-420
references.pmid: 18304003
references.citation: J Immunol. 1988 Oct 15;141(8):2629-34
references.pmid: 3171180
references.citation: Cancer Res. 1989 May 15;49(10):2722-8
references.pmid: 2713856
references.citation: Mol Cell. 2011 Aug 5;43(3):449-63
references.pmid: 21737330
references.citation: Sci Signal. 2010 Mar 30;3(115):re4
references.pmid: 20354226
references.citation: Nature. 2010 Jan 28;463(7280):549-53
references.pmid: 20111001
references.citation: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7
references.pmid: 21876153
references.citation: Hepatology. 2009 Jul;50(1):198-206
references.pmid: 19441101
references.citation: J Biol Chem. 2004 Mar 12;279(11):10822-8
references.pmid: 14701813
references.citation: Cell Signal. 2007 Oct;19(10):2056-67
references.pmid: 17644308
references.citation: Protein Cell. 2010 Feb;1(2):161-73
references.pmid: 21088703
references.citation: Cell. 2011 Apr 29;145(3):341-55
references.pmid: 21529710
references.citation: J Exp Med. 2005 Sep 19;202(6):727-32
references.pmid: 16157684
references.citation: Pathology. 1999 Aug;31(3):230-8
references.pmid: 10503269
references.citation: Mol Cell Biol. 2004 Feb;24(4):1464-9
references.pmid: 14749364
references.citation: Free Radic Biol Med. 2007 Feb 15;42(4):567-77
references.pmid: 17275689
references.citation: Mol Cell. 2011 Aug 5;43(3):432-48
references.pmid: 21737329
references.citation: J Immunol. 2003 Jul 1;171(1):247-56
references.pmid: 12817005
references.citation: Immunol Rev. 2010 Jul;236:41-53
references.pmid: 20636807
references.citation: Nature. 2011 Mar 17;471(7338):363-7
references.pmid: 21368763
references.citation: Mol Cell. 2008 Jun 20;30(6):689-700
references.pmid: 18570872
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22249-54
references.pmid: 21135236
references.citation: J Intern Med. 2010 May;267(5):526-42
references.pmid: 20433579
references.citation: J Exp Med. 2005 Dec 19;202(12):1691-701
references.pmid: 16365148
references.citation: Cell. 2009 Jun 12;137(6):1112-23
references.pmid: 19524513
references.citation: Immunity. 2004 Sep;21(3):415-28
references.pmid: 15357952
references.citation: Free Radic Biol Med. 2010 Jan 15;48(2):306-17
references.pmid: 19897030
references.citation: Immunol Today. 1995 Jan;16(1):39-43
references.pmid: 7533498
references.citation: Virology. 1996 Mar 1;217(1):384-91
references.pmid: 8599227
references.citation: Cell Death Differ. 2003 Oct;10(10):1156-64
references.pmid: 14502239
references.citation: Mol Biol Cell. 2004 Mar;15(3):1089-100
references.pmid: 14668480
references.citation: Mol Cell Biol. 2003 Jan;23(2):665-76
references.pmid: 12509464
references.citation: J Biol Chem. 1992 Mar 15;267(8):5317-23
references.pmid: 1312087
references.citation: Science. 1996 Nov 1;274(5288):787-9
references.pmid: 8864120
references.citation: Nat Chem Biol. 2005 Jul;1(2):112-9
references.pmid: 16408008
references.citation: Science. 2009 Jul 17;325(5938):332-6
references.pmid: 19498109
references.citation: Cell Death Differ. 2010 Mar;17(3):482-7
references.pmid: 19927158
references.citation: J Exp Med. 1998 May 4;187(9):1477-85
references.pmid: 9565639
references.citation: Neurochem Res. 2005 Aug;30(8):969-79
references.pmid: 16258846
references.citation: J Exp Med. 2011 Apr 11;208(4):633-41
references.pmid: 21402742
references.citation: Nature. 2011 Jul 31;477(7364):330-4
references.pmid: 21804564
references.citation: Nature. 1992 Mar 26;356(6367):314-7
references.pmid: 1372394
references.citation: J Biol Chem. 2005 Dec 23;280(51):41827-34
references.pmid: 16246838
references.citation: Sci STKE. 2006 Oct 17;2006(357):re13
references.pmid: 17047224
references.citation: Hepatology. 2007 Apr;45(4):1014-24
references.pmid: 17385212
references.citation: Nat Immunol. 2008 Sep;9(9):1037-46
references.pmid: 18641654
references.citation: Cell Host Microbe. 2010 Jul 22;8(1):44-54
references.pmid: 20638641
references.citation: Nat Rev Mol Cell Biol. 2010 Oct;11(10):700-14
references.pmid: 20823910
references.citation: J Immunol. 2007 Jun 1;178(11):7376-84
references.pmid: 17513788
references.citation: Mol Cell. 2007 Jun 8;26(5):675-87
references.pmid: 17560373
references.citation: Mol Cell Biol. 2006 Mar;26(6):2215-25
references.pmid: 16507998
references.citation: Curr Opin Cell Biol. 2010 Apr;22(2):263-8
references.pmid: 20045303