title: [The effects of chronic stress on spatial cognitive ability of different sex mice].
abstract: OBJECTIVE
  To investigate the effects of chronic stress on spatial cognitive ability in different sex mice.
  
  
  METHODS
  Thirty-two adult KM mice were divided into four groups (n=8): male control and chronic stress group, female control and chronic stress group. We used the modified Kaz's methods to build on the chronic stress model of mice, and then used the place navigational testing and the probe trial testing by the Morris water maze to measure the spatial cognitive ability of mice.
  
  
  RESULTS
  Following two weeks stress treatment, in the place navigational testing, to male group, the average latency to find the platform in water maze of chronic stress group was longer than that of the control; to female group, the average latency of chronic stress group was shorter than the control. Moreover, the male stress group showed faster swimming speed but longer latency to find the platform. In the probe trial testing the female chronic stress group spent more time in the target quadrant compared to the male chronic stress group.
  
  
  CONCLUSIONS
  Two weeks' chronic stress could impair male mice's spatial cognitive ability, but improve the female's.
authors.affiliation: College of Life Science and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Nonnal University, Wuhan 430079, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Han
authors.forename: Rui-hong
authors.initials: RH
authors.lastname: Shi
authors.forename: Xin-jia
authors.initials: XJ
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.forename: Shao-hui
authors.initials: SH
authors.lastname: Wang
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Liao
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D008297:Male; D018782:Maze Learning; D051379:Mice; D012737:Sex Factors; D013312:Stress, Physiological / Q000502:physiology*