title: Tuning of the excitability of transcortical cutaneous reflex pathways during mirror-like activity.
abstract: Voluntary contraction of a muscle generates electromyographic (EMG) activity in the homologous muscle on the opposite side (mirror-like activity), not only in pathological states and in infants but also in healthy adults. Few studies have examined whether the cutaneous reflexes during the preparatory period of a reaction time task are affected by mirror-like activity. In the present study, we investigated the modulation of the cutaneous reflexes in the left first interosseous (FDI) muscle in 9 healthy subjects while they performed a quick abduction of the right index finger during a reaction time task. Cutaneous reflexes were elicited by applying non-noxious electrical stimulation to the left index finger. We found that mirror-like activity occurred in the left FDI at approximately the onset of EMG activity in the right FDI. The excitatory E2 component was selectively increased at ~75 ms after the "Go" signal, which corresponded to the onset of mirror-like activity. The inhibitory I2 (~90 ms) component was tuned consistently into excitation after the "Go" signal. These findings suggest that long latency reflexes, possibly transcortical cutaneous reflexes, are finely tuned in relation to mirror-like activity.
authors.affiliation: Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuouku, Chiba 260-8670, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohtsuka
authors.forename: Syusaku
authors.initials: S
authors.lastname: Sasada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Genki
authors.initials: G
authors.lastname: Futatsubashi
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Komiyama
mesh_terms: D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D007839:Functional Laterality; D006801:Humans; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D013997:Time Factors; D055815:Young Adult
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