title: Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus.
abstract: Bacillus subtilis induces expression of the gene ytnP in the presence of the antimicrobial streptomycin, produced by the Gram-positive bacterium Streptomyces griseus. ytnP encodes a lactonase-homologous protein that is able to inhibit the signaling pathway required for the streptomycin production and development of aerial mycelium in S. griseus.
authors.affiliation: Institute for Molecular Infection Biology IMIB, Centre for Molecular Research in Infectious Disease ZINF, University of Würzburg, Würzburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schneider
authors.forename: Ana
authors.initials: A
authors.lastname: Yepes
authors.forename: Juan C
authors.initials: JC
authors.lastname: Garcia-Betancur
authors.forename: Isa
authors.initials: I
authors.lastname: Westedt
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mielich
authors.forename: Daniel
authors.initials: D
authors.lastname: López
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D002265:Carboxylic Ester Hydrolases / Q000096:biosynthesis* / Q000235:genetics; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D008969:Molecular Sequence Data; D013305:Streptomyces griseus / Q000235:genetics / Q000378:metabolism*; D013307:Streptomycin / Q000378:metabolism*
chemical_list: D002265:Carboxylic Ester Hydrolases; C019103:delta-lactonase; D013307:Streptomycin
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