title: Deep tissue bio-imaging using two-photon excited CdTe fluorescent quantum dots working within the biological window.
abstract: A new approach to deep tissue imaging is presented based on 8 nm CdTe semiconductor quantum dots (QDs). The characteristic 800 nm emission was found to be efficiently excited via two-photon absorption of 900 nm photons. The fact that both excitation and emission wavelengths lie within the "biological window" allows for high resolution fluorescence imaging at depths close to 2 mm. These penetration depths have been used to obtain the first deep tissue multiphoton excited fluorescence image based on CdTe-QDs. Due to the large thermal sensitivity of CdTe-QDs, one may envisage, in the near future, their use in high resolution deep-tissue thermal imaging.
authors.affiliation: Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, 28049, Spain. lm.maestro@uam.es
authors.forename: L M
authors.initials: LM
authors.lastname: Maestro
authors.forename: J E
authors.initials: JE
authors.lastname: Ramírez-Hernández
authors.forename: N
authors.initials: N
authors.lastname: Bogdan
authors.forename: J A
authors.initials: JA
authors.lastname: Capobianco
authors.forename: F
authors.initials: F
authors.lastname: Vetrone
authors.forename: J García
authors.initials: JG
authors.lastname: Solé
authors.forename: D
authors.initials: D
authors.lastname: Jaque
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D010316:Particle Size; D017785:Photons; D045663:Quantum Dots; D019265:Spectroscopy, Near-Infrared; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D013691:Tellurium; C028337:cadmium telluride