title: Novel PVC-membrane electrode for flow injection potentiometric determination of Biperiden in pharmaceutical preparations.
abstract: The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs suspension solution. Electrode matrices were optimized referring to the effect of modifier content and nature, plasticizer and the method of modification. The proposed electrodes work satisfactorily in the BP concentration range from 10(-5) to 10(-2)mol L(-1), with fast response time (7s) and adequate operational lifetime (28 days). The electrode potential is pH independent within the range 2.0-7.0, with good selectivity towards BP in presence of various interfering species. The developed electrodes have been applied for potentiometric determination of BP in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. FIA offers the advantages of accuracy and automation feasibility with high sampling frequency. The dissolution profile for Akineton tablets (2mg BP/tablet) was studied using the proposed electrode in comparison with the official methods.
authors.affiliation: Microanalysis Laboratory, National Research Centre, Dokki, Giza, Egypt. elmorsykhaled@yahoo.com
authors.forename: Elmorsy
authors.initials: E
authors.lastname: Khaled
authors.forename: Inas A
authors.initials: IA
authors.lastname: El-Sabbagh
authors.forename: N G
authors.initials: NG
authors.lastname: El-Kholy
authors.forename: E Y Abdel
authors.initials: EY
authors.lastname: Ghahni
mesh_terms: D000978:Antiparkinson Agents / Q000032:analysis*; D001712:Biperiden / Q000032:analysis*; D004566:Electrodes; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*; D011199:Potentiometry / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D004364:Pharmaceutical Preparations; D001712:Biperiden; D011143:Polyvinyl Chloride