title: Preferential base pairing modes of T·T mismatches.
abstract: It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
authors.forename: Guoyun
authors.initials: G
authors.lastname: He
authors.forename: Chun Kit
authors.initials: CK
authors.lastname: Kwok
authors.forename: Sik Lok
authors.initials: SL
authors.lastname: Lam
mesh_terms: D020137:Base Pair Mismatch; D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D009682:Magnetic Resonance Spectroscopy; D013941:Thymine
chemical_list: D004247:DNA; D013941:Thymine