title: Flavonoids: A versatile source of anticancer drugs.
abstract: An exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell has been witnessed. In search for anticancer drugs compelling data from laboratories, epidemiologic investigations, and human clinical trials showed that flavonoids have important effects on cancer chemoprevention and chemotherapy. In many molecular mechanisms of action for prevention against cancer, flavonoids play a major role by interacting between different types of genes and enzymes. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, antioxidation, and reversal of multidrug resistance or a combination of these mechanisms. This review focuses on the anticancer activity of flavonoids as well as their molecular mechanisms, including the treatment of mammary and prostate cancer. This review also highlights some advanced derivatives of flavonoids, which play an important role against cancer.
authors.affiliation: Department of Chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India.
authors.forename: Maheep K
authors.initials: MK
authors.lastname: Chahar
authors.forename: Neelu
authors.initials: N
authors.lastname: Sharma
authors.forename: Mahabeer P
authors.initials: MP
authors.lastname: Dobhal
authors.forename: Yogesh C
authors.initials: YC
authors.lastname: Joshi
references.citation: Cancer Res. 1989 Sep 15;49(18):5111-7
references.pmid: 2548712
references.citation: Am J Ther. 2001 Sep-Oct;8(5):333-44
references.pmid: 11550075
references.citation: J Nutr. 2000 Feb;130(2S Suppl):472S-478S
references.pmid: 10721932
references.citation: Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2690-4
references.pmid: 7681986
references.citation: Bioorg Med Chem Lett. 2001 Dec 17;11(24):3095-7
references.pmid: 11720850
references.citation: Nutr Rev. 1998 Nov;56(11):317-33
references.pmid: 9838798
references.citation: Arch Pharm Res. 1999 Jun;22(3):309-12
references.pmid: 10403137
references.citation: Anticancer Res. 2000 Sep- Oct;20(5B):3459-65
references.pmid: 11131648
references.citation: Biochem Pharmacol. 2000 Oct 15;60(8):1051-9
references.pmid: 11007941
references.citation: Prostate. 2001 Feb 1;46(2):98-107
references.pmid: 11170137
references.citation: Cancer Res. 2005 Dec 15;65(24):11752-61
references.pmid: 16357188
references.citation: Annu Rev Nutr. 2001;21:381-406
references.pmid: 11375442
references.citation: Clin Cancer Res. 1998 Apr;4(4):1055-64
references.pmid: 9563902
references.citation: Cancer Res. 1998 Jun 1;58(11):2379-84
references.pmid: 9622078
references.citation: Mol Cell Biochem. 2006 Jul;287(1-2):109-16
references.pmid: 16645725
references.citation: Cancer Res. 1997 Jan 15;57(2):246-52
references.pmid: 9000563
references.citation: Biochim Biophys Acta. 1994 Apr 13;1205(2):325-35
references.pmid: 8155716
references.citation: Nutr Cancer. 2000;37(2):223-33
references.pmid: 11142097
references.citation: Clin Exp Metastasis. 1991 Jan-Feb;9(1):13-25
references.pmid: 1901781
references.citation: Carcinogenesis. 2000 Jan;21(1):63-7
references.pmid: 10607735
references.citation: Leukemia. 2001 Jan;15(1):1-9
references.pmid: 11243375
references.citation: In Vitro Cell Dev Biol Anim. 2001 May;37(5):275-82
references.pmid: 11513082
references.citation: Cancer Res. 2002 Feb 15;62(4):1025-9
references.pmid: 11861377
references.citation: Eur J Cancer. 1999 Oct;35(10):1517-25
references.pmid: 10673981
references.citation: Carcinogenesis. 2007 Jul;28(7):1463-70
references.pmid: 17341659
references.citation: Z Naturforsch C J Biosci. 2009 Jan-Feb;64(1-2):32-6
references.pmid: 19323263
references.citation: Prostate. 2008 Jan 1;68(1):61-71
references.pmid: 18008333
references.citation: Arch Pharm (Weinheim). 2000 Jun;333(6):181-8
references.pmid: 10909190
references.citation: Eur J Med Chem. 2009 May;44(5):1982-8
references.pmid: 19041163
references.citation: Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:95-101
references.pmid: 15298613
references.citation: Anticancer Res. 2000 Nov-Dec;20(6B):4339-45
references.pmid: 11205268
references.citation: Am J Respir Cell Mol Biol. 1997 Jul;17(1):51-9
references.pmid: 9224209
references.citation: Biofactors. 2000;12(1-4):193-9
references.pmid: 11216486
references.citation: Life Sci. 1994;55(13):1061-9
references.pmid: 8084211
references.citation: Biol Pharm Bull. 2003 Apr;26(4):560-3
references.pmid: 12673045
references.citation: Nutr Cancer. 2002;42(2):224-32
references.pmid: 12416264
references.citation: Biosci Biotechnol Biochem. 2000 Sep;64(9):1813-20
references.pmid: 11055382
references.citation: Oncol Rep. 2009 Jun;21(6):1525-8
references.pmid: 19424633
references.citation: Cancer Lett. 1997 Jun 24;116(2):131-7
references.pmid: 9215855
references.citation: Cancer Chemother Pharmacol. 1991;28(6):409-13
references.pmid: 1934244
references.citation: Cell Growth Differ. 1996 Oct;7(10):1345-51
references.pmid: 8891338
references.citation: Cancer Res. 1990 Aug 1;50(15):4504-9
references.pmid: 1973362
references.citation: Int J Oncol. 2001 Oct;19(4):837-44
references.pmid: 11562764
references.citation: Cancer Chemother Pharmacol. 1989;24(5):269-72
references.pmid: 2667786
references.citation: Nat Rev Cancer. 2003 Oct;3(10):768-80
references.pmid: 14570043
references.citation: Int J Cancer. 1999 Mar 15;80(6):827-41
references.pmid: 10074914
references.citation: Oncogene. 1999 Dec 2;18(51):7389-94
references.pmid: 10602496
references.citation: Cancer Res. 1993 Mar 15;53(6):1328-31
references.pmid: 8443813
references.citation: Cell. 1997 Oct 31;91(3):299-302
references.pmid: 9363938
references.citation: Carcinogenesis. 1997 May;18(5):957-65
references.pmid: 9163681
references.citation: Cancer Biother Radiopharm. 1998 Dec;13(6):447-52
references.pmid: 10851437
references.citation: Int J Cancer. 2000 Aug 15;87(4):595-600
references.pmid: 10918203
references.citation: Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7490-5
references.pmid: 10377442
references.citation: Carcinogenesis. 2004 Jun;25(6):987-95
references.pmid: 14742313
references.citation: World Rev Nutr Diet. 1976;24:117-91
references.pmid: 790781
references.citation: Annu Rev Biochem. 1987;56:881-914
references.pmid: 3039909
references.citation: Thyroid. 1999 Apr;9(4):369-76
references.pmid: 10319943
references.citation: Cancer Res. 1990 Jul 1;50(13):3934-9
references.pmid: 2354442
references.citation: Pharmacol Ther. 2001 May-Jun;90(2-3):157-77
references.pmid: 11578656
references.citation: Cancer Res. 2000 Jul 15;60(14):3823-31
references.pmid: 10919656
references.citation: Carcinogenesis. 2003 Oct;24(10):1651-6
references.pmid: 12869420
references.citation: Proc Soc Exp Biol Med. 1995 Jan;208(1):124-30
references.pmid: 7892286
references.citation: J Agric Food Chem. 1999 Jan;47(1):36-41
references.pmid: 10563845
references.citation: Jpn J Cancer Res. 2000 Jul;91(7):686-91
references.pmid: 10920275
references.citation: Curr Med Chem. 2001 Feb;8(2):135-53
references.pmid: 11172671
references.citation: Blood. 1997 Dec 1;90(11):4307-12
references.pmid: 9373241
references.citation: Nutr Cancer. 2000;38(1):116-22
references.pmid: 11341036
references.citation: Anticancer Res. 2000 Jul-Aug;20(4):2525-36
references.pmid: 10953322
references.citation: J Biol Chem. 1987 Apr 25;262(12):5592-5
references.pmid: 3106339
references.citation: Anticancer Res. 1999 Sep-Oct;19(5B):4297-303
references.pmid: 10628390
references.citation: Expert Opin Investig Drugs. 2000 Sep;9(9):2103-19
references.pmid: 11060796
references.citation: Food Chem Toxicol. 1998 Aug;36(8):617-21
references.pmid: 9734711
references.citation: Oncogene. 1991 Dec;6(12):2277-84
references.pmid: 1685017
references.citation: Clin Hemorheol Microcirc. 2000;23(2-4):185-90
references.pmid: 11321439
references.citation: Cancer Res. 1996 Nov 1;56(21):4904-9
references.pmid: 8895742
references.citation: Invest New Drugs. 1999;17(3):313-20
references.pmid: 10665481
references.citation: Mol Nutr Food Res. 2009 Nov;53(11):1376-85
references.pmid: 19743405
references.citation: Cancer Res. 1991 Apr 1;51(7):1898-903
references.pmid: 2004373
references.citation: Cancer Lett. 1996 Dec 20;110(1-2):41-8
references.pmid: 9018079
references.citation: Anticancer Res. 2005 Mar-Apr;25(2A):1179-85
references.pmid: 15868960
references.citation: Biochem Pharmacol. 2002 Jan 15;63(2):225-36
references.pmid: 11841797
references.citation: Pharmacol Rev. 2000 Dec;52(4):673-751
references.pmid: 11121513
references.citation: J Natl Cancer Inst. 1999 Jul 21;91(14):1227-32
references.pmid: 10413424
references.citation: Cancer Res. 2004 Aug 1;64(15):5311-21
references.pmid: 15289337
references.citation: Eur J Cancer. 1998 Nov;34(12):1927-34
references.pmid: 10023317
references.citation: Cancer Res. 1991 Mar 1;51(5):1452-9
references.pmid: 1847663
references.citation: FEBS Lett. 1998 Oct 16;437(1-2):61-4
references.pmid: 9804172
references.citation: Nutr Cancer. 1994;21(2):113-31
references.pmid: 8058523
references.citation: Life Sci. 1997;60(24):2157-63
references.pmid: 9188758
references.citation: Biochem Pharmacol. 1999 Jul 15;58(2):303-10
references.pmid: 10423172
references.citation: Anticancer Res. 2000 May-Jun;20(3A):1733-8
references.pmid: 10928101
references.citation: Cancer Biother Radiopharm. 1996 Jun;11(3):193-6
references.pmid: 10851537
references.citation: Drug Metabol Drug Interact. 2000;17(1-4):311-49
references.pmid: 11201302
references.citation: Invest New Drugs. 2005 Jun;23(3):205-11
references.pmid: 15868376
references.citation: Biochem Pharmacol. 2001 May 15;61(10):1205-15
references.pmid: 11322924
references.citation: BioDrugs. 2001;15(7):465-89
references.pmid: 11520257
references.citation: Expert Opin Investig Drugs. 2000 Dec;9(12):2903-11
references.pmid: 11093360
references.citation: Biochem Pharmacol. 1992 Jul 7;44(1):192-5
references.pmid: 1632835
references.citation: J Natl Cancer Inst. 2000 Jan 19;92(2):154-60
references.pmid: 10639518
references.citation: Curr Med Chem. 2000 Jan;7(1):39-58
references.pmid: 10637356
references.citation: Int J Oncol. 1993 Dec;3(6):1131-9
references.pmid: 21573484
references.citation: Science. 1996 Jul 5;273(5271):59-63
references.pmid: 8658196
references.citation: Cancer Chemother Pharmacol. 1993;33(1):77-81
references.pmid: 8269593
references.citation: Life Sci. 2002 Feb 8;70(12):1447-59
references.pmid: 11883719
references.citation: Cancer Chemother Pharmacol. 2000;46(4):305-12
references.pmid: 11052628
references.citation: Cell. 1990 Apr 20;61(2):203-12
references.pmid: 2158859
references.citation: Eur J Nutr. 1999 Jun;38(3):133-42
references.pmid: 10443335
references.citation: Cancer Res. 2000 Oct 15;60(20):5617-20
references.pmid: 11059749
references.citation: Mol Carcinog. 2001 Apr;30(4):224-36
references.pmid: 11346885
references.citation: J Steroid Biochem Mol Biol. 1993 May;45(5):399-405
references.pmid: 8499347
references.citation: Acta Crystallogr C. 2007 Sep;63(Pt 9):m410-2
references.pmid: 17762110
references.citation: Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75
references.pmid: 16901994
references.citation: Adv Immunol. 1997;65:111-37
references.pmid: 9238509
references.citation: Int J Cancer. 1997 Nov 27;73(5):719-24
references.pmid: 9398052
references.citation: Anticancer Res. 2000 Jan-Feb;20(1A):271-7
references.pmid: 10769666
references.citation: J Nat Prod. 2001 Feb;64(2):181-8
references.pmid: 11429996
references.citation: Pharm Res. 2002 Mar;19(3):286-91
references.pmid: 11934235
references.citation: Anticancer Res. 1993 Nov-Dec;13(6A):2165-70
references.pmid: 8297130
references.citation: Pharmazie. 2005 Mar;60(3):233-6
references.pmid: 15801681
references.citation: Clin Exp Metastasis. 2000;18(8):657-62
references.pmid: 11827069
references.citation: Endocrinology. 1978 Nov;103(5):1860-7
references.pmid: 570914
references.citation: Chem Biol Interact. 2002 Jan 22;139(1):1-21
references.pmid: 11803026
references.citation: Annu Rev Biochem. 1988;57:443-78
references.pmid: 3052279