title: Administration of prednisolone intravenously or dexamethason orally in random donors reveals equal results in granulocyte collection: a single centre experience.
abstract: Since cytokine--mobilization for granulocyte collections in random donors--is not licensed in Austria, we investigated in a prospective analysis the effects of prednisolone or dexamethasone (DXM) in 153 donors (35 women/118 men) and in the collected products. Either prednisolone (50 mg) intravenously 4 h before granulocyte collection or DXM (8 mg) orally 12 h before collection was given. Collections were performed with the Cobe Spectra (CardianBCT, Lakewood). We recorded a significantly higher percentage of granulocytes in the peripheral blood of the DXM. However, the collected number of granulocytes was equal in both groups.
authors.affiliation: Department of Blood Group Serology and Transfusion Medicine, Medical University, Waehringer Guertel 18-20, Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Kolovratova
authors.forename: J
authors.initials: J
authors.lastname: List
authors.forename: N
authors.initials: N
authors.lastname: Worel
authors.forename: P
authors.initials: P
authors.lastname: Jilma
authors.forename: G
authors.initials: G
authors.lastname: Leitner
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001317:Austria; D001781:Blood Component Removal / Q000379:methods*; D001782:Blood Donors; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003907:Dexamethasone; D011239:Prednisolone