title: iNKTs foil fungi.
abstract: Fungal cell wall polysaccharides are potent inducers of immune responses. Cohen et al. (2011) demonstrate that innate recognition of fungal β-(1,3) glucan triggers effector functions of invariant natural killer T (iNKT) cells through indirect, cytokine-driven activation, a process that mediates optimal protection against the opportunistic mold Aspergillus fumigatus.
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mprlic@fhcrc.org
authors.forename: Martin
authors.initials: M
authors.lastname: Prlic
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Hohl
references.citation: Cell Host Microbe. 2011 Nov 17;10(5):437-50
references.pmid: 22100160
references.citation: Nat Immunol. 2011 Oct 30;12(12):1202-11
references.pmid: 22037601
references.citation: Curr Opin Microbiol. 2011 Aug;14(4):392-9
references.pmid: 21803640
references.citation: J Exp Med. 2011 Jun 6;208(6):1163-77
references.pmid: 21555485
references.citation: J Immunol. 2008 Oct 1;181(7):4452-6
references.pmid: 18802047
references.citation: J Immunol. 2009 Apr 1;182(7):4306-12
references.pmid: 19299730
references.citation: Cell Host Microbe. 2009 Nov 19;6(5):470-81
references.pmid: 19917501
references.citation: Nat Immunol. 2011 Sep 04;12(10):966-74
references.pmid: 21892173
references.citation: Nat Immunol. 2011 Jul 31;12(9):827-33
references.pmid: 21804559
references.citation: Nat Rev Microbiol. 2007 Jun;5(6):405-17
references.pmid: 17487145
references.citation: J Immunol. 2001 Dec 1;167(11):6525-32
references.pmid: 11714821