title: Resetting of brain dynamics: epileptic versus psychogenic nonepileptic seizures.
abstract: We investigated the possibility of differential diagnosis of patients with epileptic seizures (ES) and patients with psychogenic nonepileptic seizures (PNES) through an advanced analysis of the dynamics of the patients' scalp EEGs. The underlying principle was the presence of resetting of brain's preictal spatiotemporal entrainment following onset of ES and the absence of resetting following PNES. Long-term (days) scalp EEGs recorded from five patients with ES and six patients with PNES were analyzed. It was found that: (1) Preictal entrainment of brain sites was reset at ES (P<0.05) in four of the five patients with ES, and not reset (P=0.28) in the fifth patient. (2) Resetting did not occur (p>0.1) in any of the six patients with PNES. These preliminary results in patients with ES are in agreement with our previous findings from intracranial EEG recordings on resetting of brain dynamics by ES and are expected to constitute the basis for the development of a reliable and supporting tool in the differential diagnosis between ES and PNES. Finally, we believe that these results shed light on the electrophysiology of PNES by showing that occurrence of PNES does not assist patients in overcoming a pathological entrainment of brain dynamics. This article is part of a Supplemental Special Issue entitled The Future of Automated Seizure Detection and Prediction.
authors.affiliation: Department of Electrical Engineering, Ira Fulton Schools of Engineering, Arizona State University, Tempe, AZ 85287, USA.
authors.forename: Balu
authors.initials: B
authors.lastname: Krishnan
authors.forename: Aaron
authors.initials: A
authors.lastname: Faith
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vlachos
authors.forename: Austin
authors.initials: A
authors.lastname: Roth
authors.forename: Korwyn
authors.initials: K
authors.lastname: Williams
authors.forename: Katie
authors.initials: K
authors.lastname: Noe
authors.forename: Joe
authors.initials: J
authors.lastname: Drazkowski
authors.forename: Lisa
authors.initials: L
authors.lastname: Tapsell
authors.forename: Joseph
authors.initials: J
authors.lastname: Sirven
authors.forename: Leon
authors.initials: L
authors.lastname: Iasemidis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves; D003291:Conversion Disorder / Q000175:diagnosis*; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011602:Psychophysiologic Disorders / Q000175:diagnosis* / Q000523:psychology; D055815:Young Adult
references.citation: Clin Electroencephalogr. 1997 Oct;28(4):225-8
references.pmid: 9343716
references.citation: Epilepsia. 2000 Oct;41(10):1330-4
references.pmid: 11051130
references.citation: Phys Rev A Gen Phys. 1986 Dec;34(6):4971-4979
references.pmid: 9897880
references.citation: Seizure. 1997 Aug;6(4):243-53
references.pmid: 9304716
references.citation: Neurology. 2001 Sep 11;57(5):915-7
references.pmid: 11552032
references.citation: Neuroscience. 1999;91(4):1315-9
references.pmid: 10391438
references.citation: J Neurol. 2003 Mar;250(3):338-46
references.pmid: 12638026
references.citation: Clin Neurol Neurosurg. 2009 Jan;111(1):1-9
references.pmid: 19019531
references.citation: Seizure. 1992 Mar;1(1):19-26
references.pmid: 1344315
references.citation: Seizure. 2009 Oct;18(8):543-53
references.pmid: 19682927
references.citation: Neuropsychol Rev. 2002 Mar;12(1):31-64
references.pmid: 12090718
references.citation: Seizure. 2000 Jun;9(4):280-1
references.pmid: 10880289
references.citation: IEEE Trans Biomed Eng. 2004 Mar;51(3):493-506
references.pmid: 15000380
references.citation: Epilepsy Behav. 2003 Jun;4(3):354-9
references.pmid: 12791342
references.citation: Am J Psychiatry. 2002 Apr;159(4):660-3
references.pmid: 11925308
references.citation: Epilepsia. 1975 Mar;16(1):1-66
references.pmid: 804401
references.citation: Epilepsy Behav. 2003 Jun;4(3):241-5
references.pmid: 12791325
references.citation: Brain Res Bull. 2002 May;58(1):115-28
references.pmid: 12121821
references.citation: Epilepsia. 2010 Jul;51(7):1159-68
references.pmid: 20384722
references.citation: Epilepsy Behav. 2004 Dec;5(6):818-25
references.pmid: 15582828
references.citation: Seizure. 1998 Oct;7(5):385-90
references.pmid: 9808114
references.citation: Seizure. 2002 Apr;11(3):193-7
references.pmid: 12018963
references.citation: Psychosomatics. 2007 May-Jun;48(3):230-8
references.pmid: 17478592
references.citation: Neurol Clin. 1994 Feb;12(1):153-73
references.pmid: 8183208
references.citation: Epilepsy Behav. 2003 Jun;4(3):205-16
references.pmid: 12791321
references.citation: Neurosurg Clin N Am. 2011 Oct;22(4):489-506, vi
references.pmid: 21939848
references.citation: Epilepsy Behav. 2008 May;12(4):622-35
references.pmid: 18164250
references.citation: Dev Med Child Neurol. 2001 Aug;43(8):547-51
references.pmid: 11508920
references.citation: J Clin Neurophysiol. 2003 Feb;20(1):42-4
references.pmid: 12684557
references.citation: Brain Topogr. 1990 Spring;2(3):187-201
references.pmid: 2116818
references.citation: Epilepsia. 1999 Apr;40(4):485-91
references.pmid: 10219276
references.citation: Neurology. 2002 Feb 12;58(3):493-5
references.pmid: 11839862
references.citation: Seizure. 1999 Jun;8(4):223-7
references.pmid: 10452920
references.citation: Seizure. 2003 Jul;12(5):287-94
references.pmid: 12810341
references.citation: J Comb Optim. 2009 Jan;17(1):74-97
references.pmid: 21709753
references.citation: Australas Phys Eng Sci Med. 2001 Mar;24(1):37-48
references.pmid: 11458571
references.citation: Epilepsia. 2004 Nov;45(11):1344-50
references.pmid: 15509235
references.citation: Epilepsy Behav. 2005 Mar;6(2):174-8
references.pmid: 15710300
references.citation: Epilepsy Behav. 2005 Jun;6(4):593-600
references.pmid: 15907754