title: New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity.
abstract: Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Chou
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000494:pharmacology; D031369:Cryptocarya / Q000737:chemistry*; D044950:Flavanones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D044950:Flavanones; D011753:Pyrones; C548572:cryptocaryone; C016063:pinocembrin