title: Tramadol hydrochloride/acetaminophen combination for the relief of acute pain.
abstract: Tramadol hydrochloride/acetaminophen is a combination drug containing tramadol hydrochloride 37.5 mg and acetaminophen 325 mg. The use of 25% less tramadol in the combination product reduces the incidence of tramadol-related adverse events, while the addition of acetaminophen reduces the onset time of analgesia and improves the degree of analgesia. However, there was no clinically significant difference in the pharmacokinetic parameters of tramadol or acetaminophen when the fixed-dose combination was compared with the individual agents after multiple-dose administration. The onset time of tramadol hydrochloride/acetaminophen was the fastest at only 17 minutes compared 51 minutes for tramadol and 18 minutes for acetaminophen. This combination has been found to be effective in the management of postoperative pain. It improves pain relief and provides a faster onset and longer duration of action with fewer adverse events than either component separately. It also reduces the severity of pain, photophobia and phonophobia associated with migraine headache. Tramadol hydrochloride/acetaminophen has been shown to be most effective in patients with mild to moderate pain and has a lower risk of serious adverse events.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. psawaddi@med.cmu.ac.th
authors.forename: P
authors.initials: P
authors.lastname: Sawaddiruk
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D059787:Acute Pain / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D000082:Acetaminophen; D014147:Tramadol