title: Is time on cardiopulmonary bypass during cardiac surgery associated with acute kidney injury requiring dialysis?
abstract: It is commonly accepted that the longer the time on extracorporeal cardiopulmonary bypass (CPB), the higher is the likelihood of developing acute renal failure requiring dialysis (ARF-D). Nonetheless, previous works elicited conflicting evidence. We investigated the relationship between CPB duration and ARF-D occurrence. Data were extracted from a large observational study. All factors independently associated with ARF-D were detected. Overall, 11,092 case record forms were analyzed. At the univariate analyses, time on CBP was associated with an increase in the ARF-D risk (odds ratio of fifth vs. first quintile of CBP time: 3.84; 95% confidence interval: 2.58-5.7; P < 0.001). However, after adjusting for confounders, the association between time on CBP and ARF-D lost its statistical significance. In this large dataset, CBP time did not predict ARF-D occurrence. These results might suggest that an accurate risk assessment might be more important than time on CPB in determining ARF-D occurrence.
authors.affiliation: Nephrology, Dialysis and Hypertension Unit, Policlinico S.Orsola-Malpighi, Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Mancini
authors.forename: Fabio
authors.initials: F
authors.lastname: Caramelli
authors.forename: Marco
authors.initials: M
authors.lastname: Ranucci
authors.forename: Diego
authors.initials: D
authors.lastname: Sangiorgi
authors.forename: Letizia Bacchi
authors.initials: LB
authors.lastname: Reggiani
authors.forename: Guido
authors.initials: G
authors.lastname: Frascaroli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Zucchelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Bellasi
authors.forename: Antonio
authors.initials: A
authors.lastname: Santoro
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D012307:Risk Factors; D013997:Time Factors