title: [Effects of modified bazhen decoction in assistant with enteral nutrition on the growth hormone, the nutritional state, and the immune function in patients with gastric cancer after operation].
abstract: OBJECTIVE
  To observe the effects of modified Bazhen Decoction (BZD) in assistant with enteral nutrition (EN) on the growth hormone, the nutritional state, and the immune function in patients with gastric cancer after operation.
  
  
  METHODS
  The prospective, random, single-blinded, controlled clinical trial was adopted. 88 patients receiving gastric cancer operation were randomly assigned to the parenteral nutrition group (Group A, 27 cases), the EN group (Group B, 30 cases), and the comprehensive group (Group C, BZD in assistant with EN, 31 cases). Isocaloric and isonitrogenous parenteral nutritional support was given to patients in Group A from the operation day to the ninth day. Isocaloric and isonitrogenous EN was given to patients in Group B and C from the second day of operation till the ninth day. 100 mL BZD was nasal fed to patients in Group C during the second day to the ninth day after operation. The levels of the growth hormone, immune indices such as IgA, IgG, CD4+, CD8+, and CD4+/CD8+, etc., and nutritional indices such as serum albumin, prealbumin, transferrin, etc. were detected in the three groups one day before operation, on the 1st day after operation, and on the tenth day after operation.
  
  
  RESULTS
  The levels of IgA, IgG, CD4+, and CD4+/CD8+, serum albumin, prealbumin, transferrin decreased more than before operation in the three groups, with statistical difference (P<0.05). On the tenth day after operation, all indices in Group B and C were somewhat improved, showing statistical difference when compared with those in Group A (P<0.05). Besides, the aforesaid indices were higher in Group C than in Group B (P<0.05).
  
  
  CONCLUSIONS
  Modified BZD in assistant with EN could further promote the elevation of the growth hormone levels. Besides, it could further improve the nutrition state and the immune function.
authors.affiliation: Department of Clinical Nutrition, Affiliated Third Hospital of Nantong University, Jiangsu. wanghongxing83@163.com
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Wang
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004750:Enteral Nutrition; D005260:Female; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D008517:Phytotherapy; D011184:Postoperative Period; D011446:Prospective Studies; D016037:Single-Blind Method; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery
chemical_list: D004365:Drugs, Chinese Herbal; D013006:Growth Hormone