title: Lipid-related residual risk and renal function for occurrence and prognosis among patients with first-event acute coronary syndrome and normal LDL cholesterol.
abstract: BACKGROUND
  We investigated relationship of low levels of high density lipoprotein cholesterol (HDL-C), high levels of triglycerides, and renal function for the odds, prognosis and survival following acute coronary events among patients with a first event and normal low density lipoprotein cholesterol levels.
  
  
  RESULTS
  A case-control study based on 557 patients and 1086 matched control subjects was conducted. Case patients were followed up for survival with a median of 1.9 years. Participants in the higher quintiles of HDL-C had lower odds to develop acute coronary events (the adjusted odds ratios were 0.24 for the second, 0.24 for the third, 0.10 for the fourth and 0.05 for the fifth quintile). Patients with normal glomerular filtration rate were at a lower risk for all-cause death. However, a reverse association between triglycerides and death risk was found: patients with higher triglycerides were at a lower risk for all-cause death (adjusted relative risk, 0.38 for triglycerides ranging from 82 to 132.9 mg/dL, and 0.14 for triglycerides > = 133 mg/dL).
  
  
  CONCLUSIONS
  Low HDL-C was significantly associated with acute coronary events, and triglyceride levels as well as renal function were inversely related to all-cause deaths after the coronary event.
authors.affiliation: Institute of Epidemiology & Preventive Medicine, National Taiwan University, Taipei, Taiwan. klchien@ntu.edu.tw
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Lin
authors.forename: Hsiu-Ching
authors.initials: HC
authors.lastname: Hsu
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000401:mortality*; D000368:Aged; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
references.citation: Circulation. 2007 Jan 30;115(4):450-8
references.pmid: 17190864
references.citation: Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):433-42
references.pmid: 17563461
references.citation: Am J Med. 1977 May;62(5):707-14
references.pmid: 193398
references.citation: N Engl J Med. 2004 Sep 23;351(13):1296-305
references.pmid: 15385656
references.citation: J Am Coll Cardiol. 2003 Apr 16;41(8):1364-72
references.pmid: 12706933
references.citation: JAMA. 2007 Jul 18;298(3):309-16
references.pmid: 17635891
references.citation: Diab Vasc Dis Res. 2008 Nov;5(4):319-35
references.pmid: 18958843
references.citation: Lancet. 2005 Oct 8;366(9493):1267-78
references.pmid: 16214597
references.citation: Diabetes Care. 2008 Jan;31 Suppl 1:S12-54
references.pmid: 18165335
references.citation: Eur Heart J. 2007 Oct;28(19):2375-414
references.pmid: 17726041
references.citation: Circulation. 2007 Jan 2;115(1):114-26
references.pmid: 17192512
references.citation: Eur Heart J. 2005 Jan;26(1):5-7
references.pmid: 15615792
references.citation: Kidney Int. 1999 Dec;56(6):2214-9
references.pmid: 10594797
references.citation: Circulation. 2002 Dec 17;106(25):3143-421
references.pmid: 12485966
references.citation: Curr Med Res Opin. 2010 Aug;26(8):1793-7
references.pmid: 20482323
references.citation: JAMA. 2007 Jul 18;298(3):299-308
references.pmid: 17635890
references.citation: N Engl J Med. 2005 Apr 7;352(14):1425-35
references.pmid: 15755765
references.citation: Atherosclerosis. 2008 Apr;197(2):860-7
references.pmid: 17854811
references.citation: Am J Cardiol. 2010 Sep 15;106(6):757-63
references.pmid: 20816113
references.citation: Stroke. 2007 Jun;38(6):1873-80
references.pmid: 17446429
references.citation: Ann Intern Med. 1999 Mar 16;130(6):461-70
references.pmid: 10075613
references.citation: Am J Cardiol. 1992 Sep 15;70(7):733-7
references.pmid: 1519522
references.citation: Am Heart J. 2009 Jan;157(1):111-117.e2
references.pmid: 19081406
references.citation: Kidney Int. 2002 Apr;61(4):1486-94
references.pmid: 11918756
references.citation: Circulation. 2002 Jan 22;105(3):310-5
references.pmid: 11804985
references.citation: Semin Dial. 2004 May-Jun;17(3):229-32
references.pmid: 15144550
references.citation: Arch Intern Med. 2003 Jul 14;163(13):1549-54
references.pmid: 12860577
references.citation: Clin Chem. 1977 May;23(5):882-4
references.pmid: 192488
references.citation: Stat Med. 1989 May;8(5):551-61
references.pmid: 2657958
references.citation: Am J Cardiol. 2007 Nov 15;100(10):1499-501
references.pmid: 17996508
references.citation: Lancet. 2004 Sep 11-17;364(9438):937-52
references.pmid: 15364185
references.citation: BMC Genet. 2003 Apr 23;4:7
references.pmid: 12710891
references.citation: Blood Purif. 2010;29(2):150-7
references.pmid: 20093821
references.citation: J Am Soc Nephrol. 2004 May;15(5):1307-15
references.pmid: 15100371
references.citation: Lancet. 2008 Jun 28;371(9631):2173-82
references.pmid: 18586172
references.citation: N Engl J Med. 2004 Apr 8;350(15):1495-504
references.pmid: 15007110
references.citation: Lancet. 2008 Jan 12;371(9607):117-25
references.pmid: 18191683