title: [Two new asterosaponins from the antarctic starfish Diplasterias brucei. Structures and cytotoxic activities].
abstract: Two new asterosaponins, diplasteriosides A and B, with the same oligosaccharide chains beta-D-Fucp-(1-->2)-beta-D-Galp-(1-->4)-[beta-D-Quip-(1-->2)]-beta-D-Quip-(1-->3)-beta-D-Quip-(1-->, linked to C6 of known genins, 3-O-sulfates of thornasterols A and B, respectively, were isolated along with the previously known asteriidoside A from the Antarctic starfish Diplasterias brucei. The structures of new compounds were elucidated by spectroscopic methods (mainly 2D NMR and mass spectrometry). The cytotoxicity of isolated asterosaponins against human colon cancer cell line HCT-116, human breast cancer cell line T-47D, and human melanoma cancer cell line RPMI-7951 was investigated.
authors.forename: N V
authors.initials: NV
authors.lastname: Ivanchina
authors.forename: T V
authors.initials: TV
authors.lastname: Maliarenko
authors.forename: A A
authors.initials: AA
authors.lastname: Kicha
authors.forename: A I
authors.initials: AI
authors.lastname: Kalinovskiĭ
authors.forename: P S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: S P
authors.initials: SP
authors.lastname: Ermakova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012503:Saponins; C568734:diplasterioside A; C568735:diplasterioside B