title: Assessing the degradation profile of functional aliphatic polyesters with precise control of the degradation products.
abstract: The pre-polymer poly(but-2-ene-1,4-diyl malonate) (PBM) and a series of PBM-based materials are shown to be degradable under physiological conditions in vitro and they are therefore presented as potential materials for biomedical applications. Four different PBM-based materials are synthesized: a PBM homopolymer, crosslinked PBM with and without spacer, and a triblock copolymer of PBM and PLLA with the PBM as an amorphous middle block. The polymers are subjected to hydrolytic degradation in phosphate-buffered saline at pH = 7.4 and 37 °C. The results show that all the PBM-based materials degrade without a rapid release of acidic degradation products or any substantial lowering of the pH that might jeopardize their biocompatibility.
authors.affiliation: Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Höglund
authors.forename: Sofia
authors.initials: S
authors.lastname: Målberg
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Albertsson
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis*; D008401:Gas Chromatography-Mass Spectrometry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D019344:Lactic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000737:chemistry; D011090:Polyenes / Q000737:chemistry; D011091:Polyesters / Q000032:analysis / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*; D014466:Ultraviolet Rays; D014867:Water
chemical_list: D001672:Biocompatible Materials; D008314:Malonates; D011090:Polyenes; D011091:Polyesters; D011108:Polymers; D014867:Water; D019344:Lactic Acid; C033616:poly(lactide); C008952:polybutene