title: [Use of cyanoacrylate in the endoscopic therapy of gastric varices: experience in the National Hospital Edgardo Rebagliati Martins from 2006 to 2010].
abstract: OBJECTIVE
  To evaluate the therapeutic success of the injection of N-butyl-2 cyanoacrylate in the treatment of gastric varices.
  
  
  METHODS
  Cross-sectional study included 33 patients with gastric varices who only received cyanoacrylate endoscopic therapy between 2006 and 2010. Intravariceally, cyanoacrylate was injected in a 1:1 dilution with lipiodol until the obliteration of varices. The therapeutic situation was: active bleeding, varices with stigmata of recent bleeding and secondary prophylaxis. Treatment success was evaluated according to hemostasis, recurrent bleeding and obliteration.
  
  
  RESULTS
  Of the 33 patients, 3 (9.1%) were for active bleeding, 20 (60.6%) with stigmata of recent bleeding and 10 (30.3%) as secondary prophylaxis. Gastric varices were GOV2, 17 (51.5%); IGV1, 14 (42.4%); GOV1, 2 (6.1%). Hemostasis was achieved in 21 (91.3%) and in 2 (66.7%) of 3 patients with active bleeding. Five (15.6%) patients had recurrent bleeding and 2 of them used cyanoacrylate with successful hemostasis. Obliteration was achieved. Four patients died and one for failure of control bleeding. A high severity of Child-Pugh classification was related to treatment endoscopic failure (p=0.034). The main complication was bleeding after the injection of cyanoacrylate.
  
  
  CONCLUSIONS
  Our results support the use of cyanoacrylate in the treatment of gastric varices with few major complications.
authors.affiliation: Departamento de Aparato Digestivo del Hospital Edgardo Rebagliati Martins, Essalud - Lima, Perú. brisaida2@yahoo.es
authors.forename: Ofelia
authors.initials: O
authors.lastname: Castillo
authors.forename: Fernando
authors.initials: F
authors.lastname: Palacios
authors.forename: Max
authors.initials: M
authors.lastname: Yoza
authors.forename: Carlos
authors.initials: C
authors.lastname: Contardo
authors.forename: César
authors.initials: C
authors.lastname: Soriano
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004659:Enbucrilate / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D005773:Gastroscopy; D016558:Hemostasis, Endoscopic; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D015911:Sclerotherapy; D016896:Treatment Outcome
chemical_list: D012597:Sclerosing Solutions; D004659:Enbucrilate