title: ¹H-magnetic resonance spectroscopy of the breast at 3.0-T: comparison of results obtained before and after administration of gadolinium-based contrast agent.
abstract: OBJECTIVE
  To assess the effects of gadolinium-based contrast agent (GBCA) on (1) H-magnetic resonance spectroscopy (MRS) of the breast at 3.0-T.
  
  
  METHODS
  Patients (n = 98) with breast cancer (98 lesions) underwent MRS (point-resolved spectroscopy sequence [PRESS]; TR/TE, 2000/100 msec; voxel size, 15 × 15 × 15 mm) before the administration of GBCA. In 52 of those patients, MRS was also performed after the administration of GBCA. The voxel-of-interest (VOI) was placed by referring to the noncontrast-enhanced MRI (diffusion-weighted images combined with fat-suppressed T2-weighted images). We reviewed and graded the appropriateness of VOI location compared to the correlating enhancement lesions. Integral values of the choline peak at a frequency of 3.2 ppm on MRS were compared before and after the administration of GBCA.
  
  
  RESULTS
  The VOI was placed correctly in 64 lesions (65%), although the VOI was placed outside the targeted lesion in 34 lesions (35%). The integral value of the choline peak on MRS decreased significantly after the administration of GBCA (P < 0.001).
  
  
  CONCLUSIONS
  Accumulation of GBCA in breast cancer could affect the choline peak on MRS. MRS of breast cancer at 3.0-T can be recommended to be acquired before contrast-enhanced study; however, some problems remain in VOI placement with reference to the noncontrast-enhanced study.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkawai@med.nagoya-u.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawai
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Satake
authors.forename: Satoko
authors.initials: S
authors.lastname: Ishigaki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Minako
authors.initials: M
authors.lastname: Mori
authors.forename: Katsuya
authors.initials: K
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018567:Breast Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D002794:Choline / Q000378:metabolism; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA; D002794:Choline