title: Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
abstract: BACKGROUND
  Fat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population.
  
  
  RESULTS
  As part of the Korean Longitudinal Study on Health and Aging, which is a community-based cohort study of people aged more than 65 years, subjects (287 male, 75.9±8.6 years and 278 female, 76.0±8.8 years) with regional body composition data using Dual energy X-ray absorptiometry for android/gynoid area, computed tomography for visceral/subcutaneous adipose tissue (VAT/SAT), and cardiometabolic markers including adiponectin and high-sensitivity CRP were enrolled. We investigated the relationship between regional body composition and MS in multivariate regression models. Mean VAT and SAT area was 131.4±65.5 cm(2) and 126.9±55.2 cm(2) in men (P = 0.045) and 120.0±46.7 cm(2) and 211.8±65.9 cm(2) in women (P<0.01). Mean android and gynoid fat amount was 1.8±0.8 kg and 2.5±0.8 kg in men and 2.0±0.6 kg and 3.3±0.8 kg in women, respectively (both P<0.01). VAT area and android fat amount was strongly correlated with most metabolic risk factors compared to SAT or gynoid fat. Furthermore, android fat amount was significantly associated with clustering of MS components after adjustment for multiple parameters including age, gender, adiponectin, hsCRP, a surrogate marker of insulin resistance, whole body fat mass and VAT area.
  
  
  CONCLUSIONS
  Our findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Seon Mee
authors.initials: SM
authors.lastname: Kang
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Yoon
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Ahn
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Kyoung Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Hayley
authors.initials: H
authors.lastname: Shin
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
authors.forename: Soo
authors.initials: S
authors.lastname: Lim
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging / Q000378:metabolism
references.citation: Am J Respir Crit Care Med. 2002 Sep 15;166(6):809-13
references.pmid: 12231489
references.citation: Am J Epidemiol. 2000 Nov 15;152(10):908-11; discussion 912
references.pmid: 11092432
references.citation: J Nutr Health Aging. 2006 Mar-Apr;10(2):154-60
references.pmid: 16554953
references.citation: Int J Obes (Lond). 2010 Jan;34(1):105-10
references.pmid: 19806159
references.citation: Nature. 2006 Dec 14;444(7121):881-7
references.pmid: 17167477
references.citation: Diabetes Care. 2001 Apr;24(4):683-9
references.pmid: 11315831
references.citation: Int J Obes (Lond). 2010 Apr;34(4):733-41
references.pmid: 20065979
references.citation: Obes Rev. 2010 Jan;11(1):11-8
references.pmid: 19656312
references.citation: Am J Clin Nutr. 2004 Aug;80(2):271-8
references.pmid: 15277145
references.citation: BJOG. 2009 Feb;116(3):442-51
references.pmid: 19187378
references.citation: Curr Opin Cardiol. 2008 Nov;23(6):591-8
references.pmid: 18830075
references.citation: Obesity (Silver Spring). 2010 Jan;18(1):153-60
references.pmid: 19498348
references.citation: Circulation. 2009 Mar 31;119(12):1586-91
references.pmid: 19289634
references.citation: Metabolism. 2009 Nov;58(11):1663-8
references.pmid: 19632696
references.citation: Int J Obes Relat Metab Disord. 2002 Jul;26(7):978-83
references.pmid: 12080453
references.citation: Radiology. 1999 Apr;211(1):283-6
references.pmid: 10189485
references.citation: Obesity (Silver Spring). 2009 Jan;17(1):188-95
references.pmid: 18948962
references.citation: Lancet. 2005 Sep 24-30;366(9491):1059-62
references.pmid: 16182882
references.citation: Physiol Rev. 2000 Apr;80(2):649-80
references.pmid: 10747204
references.citation: Obesity (Silver Spring). 2010 Apr;18(4):826-32
references.pmid: 19661959
references.citation: N Engl J Med. 2007 Nov 29;357(22):2277-84
references.pmid: 18046031
references.citation: Diabetes Metab J. 2011 Apr;35(2):138-48
references.pmid: 21738896
references.citation: Nutr Rev. 2004 Jul;62(7 Pt 2):S120-6
references.pmid: 15387477
references.citation: Atherosclerosis. 2009 Jul;205(1):156-62
references.pmid: 19095235
references.citation: Ann N Y Acad Sci. 2000 May;904:317-26
references.pmid: 10865763
references.citation: Circulation. 1975 Apr;51(4 Suppl):5-40
references.pmid: 1116248
references.citation: Eur J Clin Nutr. 2011 Jan;65(1):140-2
references.pmid: 20842171
references.citation: J Am Coll Nutr. 1989 Dec;8(6):504-14
references.pmid: 2695550
references.citation: JAMA. 2001 May 16;285(19):2486-97
references.pmid: 11368702
references.citation: JAMA. 1998 Dec 2;280(21):1843-8
references.pmid: 9846779
references.citation: Lancet. 2005 May 21-27;365(9473):1817-20
references.pmid: 15910955
references.citation: Circulation. 2007 Jul 3;116(1):39-48
references.pmid: 17576866
references.citation: Circulation. 2003 Nov 18;108(20):2460-6
references.pmid: 14581396
references.citation: Diabetologia. 1985 Jul;28(7):412-9
references.pmid: 3899825
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15430-5
references.pmid: 19706383
references.citation: J Am Coll Cardiol. 2011 May 10;57(19):1887-9
references.pmid: 21545945
references.citation: Obesity (Silver Spring). 2011 Mar;19(3):631-8
references.pmid: 20706206
references.citation: Arch Pediatr Adolesc Med. 2009 Sep;163(9):826-31
references.pmid: 19736336
references.citation: Calcif Tissue Int. 2010 Feb;86(2):116-25
references.pmid: 19957167
references.citation: Am J Clin Nutr. 1995 Sep;62(3):527-32
references.pmid: 7661113
references.citation: Crit Pathw Cardiol. 2007 Jun;6(2):51-9
references.pmid: 17667865