title: Stem cell senescence and regenerative paradigms.
abstract: The term "cellular senescence" denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it.
authors.affiliation: Department of Medical and Biological Sciences, University of Udine, Udine, Italy. antonio.beltrami@uniud.it
authors.forename: A P
authors.initials: AP
authors.lastname: Beltrami
authors.forename: D
authors.initials: D
authors.lastname: Cesselli
authors.forename: C A
authors.initials: CA
authors.lastname: Beltrami
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology / Q000628:therapy; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000473:pathology / Q000628:therapy; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends*; D013234:Stem Cells / Q000473:pathology* / Q000502:physiology*