title: Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease.
abstract: Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI=500ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model.
authors.affiliation: Laboratory of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. kishimot@kph.bunri-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Ikuko
authors.initials: I
authors.lastname: Oku
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nishigawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishimoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kirino
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D001767:Blinking / Q000235:genetics / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D004195:Disease Models, Animal; D004576:Electromyography; D006801:Humans; D007859:Learning Disabilities / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics; D009154:Mutation / Q000235:genetics; D011930:Reaction Time / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor