title: Corin in clinical laboratory diagnostics.
abstract: Corin is a transmembrane serine protease identified in the heart, where it converts natriuretic peptides from inactive precursors to mature active forms. Studies in animal models and patients with hypertension and heart disease demonstrate that corin is critical in maintaining normal blood pressure and cardiac function. Like many proteolytic enzymes, corin expression and activity are regulated. Cell biology experiments indicate that transcriptional control, intracellular protein trafficking, cell surface targeting, zymogen activation and ectodomain shedding are important mechanisms in regulating corin expression and activity in the heart. More recently, soluble corin was detected in human blood and its levels were found to be reduced in patients with heart failure (HF). These findings indicate that corin deficiency may be involved in the pathogenesis of HF and suggest that soluble corin may be used as a biomarker for the disease. In this review, we describe the function and regulation of corin and discuss recent studies of soluble corin in human blood and its potential use as a biomarker for HF.
authors.affiliation: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China. ningzheng_dong@yahoo.com.cn
authors.forename: Ningzheng
authors.initials: N
authors.lastname: Dong
authors.forename: Shenghan
authors.initials: S
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003933:Diagnosis; D015971:Gene Expression Regulation, Enzymologic; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D017434:Protein Structure, Tertiary; D012697:Serine Endopeptidases / Q000097:blood / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: C119812:CORIN protein, human; D012697:Serine Endopeptidases
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