title: Antifungal prophylaxis in pediatric hematology/oncology: new choices & new data.
abstract: A severe complication of the treatment of pediatric cancers is the development of an invasive fungal infection (IFI). The data to support antifungal prophylaxis in pediatric oncology patients derive primarily from adult patients, and thus the optimal agent to utilize is not clear. Fluconazole has been a standard option, but agents with antimold activity are now available, each with limitations. Pediatric dosing for voriconazole and posaconazole is uncertain and multiple drug interactions exist. The echinocandins are well-tolerated, but only available in intravenous form. Ultimately, studies demonstrating biologic risk factors for the development of IFI may lead to personalized prophylactic strategies.
authors.affiliation: Division of Pediatric Blood & Marrow Transplant, Department of Pediatrics, University of California San Francisco, San Francisco, California 94143-1278, USA. dvorakc@peds.ucsf.edu
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Dvorak
authors.forename: Brian T
authors.initials: BT
authors.lastname: Fisher
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.forename: William J
authors.initials: WJ
authors.lastname: Steinbach
authors.forename: Michael
authors.initials: M
authors.lastname: Nieder
authors.forename: Sarah
authors.initials: S
authors.lastname: Alexander
authors.forename: Theoklis E
authors.initials: TE
authors.lastname: Zaoutis
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009181:Mycoses / Q000401:mortality / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents
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