title: Surface properties of bacteria sensitive and resistant to the class IIa carnobacteriocin Cbn BM1.
abstract: OBJECTIVE
  Class IIa bacteriocins are small antimicrobial peptides synthesized by lactic acid bacteria. The proposed mechanisms of action for class IIa bacteriocins suggest that the physicochemical properties of the target bacterial surface govern the bacteriocin antimicrobial activity. The aim of this study is to decipher the relationship between both sensitivity and resistance to a class IIa bacteriocin, carnobacteriocin BM1 and physicochemical surface properties of bacteria.
  
  
  RESULTS
  The study was performed on 18 strains by a microbial adhesion to solvents process and with electrophoretic mobility measurements considering bacteria as soft particles. A large variation in bacterial surface properties is observed among the bacterial populations. Electro-hydrodynamic parameters values appear to be more homogeneous for sensitive strains than for the resistant ones, which can exhibit more extreme values.
  
  
  CONCLUSIONS
  Physicochemical surface properties of 18 strains determined show large variations between the strains. However, no direct link between these surface properties and the resistant/sensitive phenotypes of the strains can be stated.
  
  
  CONCLUSIONS
  The surface physicochemical properties tested have a low predictive power to discriminate sensitive or resistant strains when determined at the bacterial population scale.
authors.affiliation: Laboratoire d'Ingénierie des Biomolécules, Ecole Nationale Supérieure d'Agronomie et des Industries Alimentaires, Vandoeuvre-lès-Nancy, France.
authors.forename: T
authors.initials: T
authors.lastname: Jacquet
authors.forename: C
authors.initials: C
authors.lastname: Cailliez-Grimal
authors.forename: F
authors.initials: F
authors.lastname: Borges
authors.forename: C
authors.initials: C
authors.lastname: Gaiani
authors.forename: G
authors.initials: G
authors.lastname: Francius
authors.forename: J F L
authors.initials: JF
authors.lastname: Duval
authors.forename: Y
authors.initials: Y
authors.lastname: Waldvogel
authors.forename: A-M
authors.initials: AM
authors.lastname: Revol-Junelles
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D001430:Bacteriocins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D057446:Hydrodynamics; D057927:Hydrophobic and Hydrophilic Interactions; D007777:Lactobacillaceae / Q000187:drug effects; D010641:Phenotype; D025341:Principal Component Analysis; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins