title: Presumed cytomegalovirus-associated retrobulbar optic neuritis in a patient after allogeneic stem cell transplantation.
abstract: A case of cytomegalovirus (CMV)-associated bilateral retrobulbar optic neuritis (ON) following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is reported. Abrupt onset of bilateral decreased vision occurred in a 33-year-old man 7 months after haplo-HSCT. His cerebrospinal fluid (CSF) demonstrated pleocytosis with an absence of leukemic cells. CMV DNA was detected in his blood and CSF sample. Neither encephalopathy nor retinopathy was found in this patient. He was diagnosed with bilateral retrobulbar ON. Although he was given enough antiviral treatment against CMV and immunosuppression with high-dose methylprednisolone, the patient's vision showed no improvement, and he has almost total bilateral blindness. This is the first report, to our knowledge, of CMV-associated bilateral retrobulbar ON in allogeneic stem cell transplantation.
authors.affiliation: Department of Hematology, The General Hospital of Air Force P.L.A., Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Zheng
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Yan
authors.forename: S
authors.initials: S
authors.lastname: Pan
authors.forename: H
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001766:Blindness / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D017245:Foscarnet / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009902:Optic Neuritis / Q000150:complications* / Q000821:virology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D017245:Foscarnet; D008775:Methylprednisolone