title: Effect of intense pulsed light on rat skin.
abstract: BACKGROUND
  Intense pulsed light (IPL) is widely used in treating skin conditions and has been reported to increase collagen and elastic fibers without damaging the epidermis.
  
  
  OBJECTIVE
  To evaluate the effect of variation in the number of passes and intervals of IPL treatments on photorejuvenation in rats.
  
  
  METHODS
  Groups of two rats each were exposed to two or four passes of an IPL source using a fluence of 30 J/cm(2)  and a cut-off filter of 560 nm at 1- or 3-week intervals. The collagen and elastic fiber content in stained tissue biopsies and the thickness of the collagen fibers of IPL-irradiated and unexposed skin regions were compared.
  
  
  RESULTS
  Collagen distribution and collagen fiber diameter was in IPL-irradiated than in control regions. The number of passes did not significantly affect the collagen fiber thickness, but the collagen fibers from the 3-week-interval groups were thicker than those of the 1-week-interval groups (p < .001).
  
  
  CONCLUSIONS
  IPL increased dermal collagen fibers and collagen fiber diameter, suggesting efficacy in photorejuvenation and wrinkle reduction.
authors.affiliation: Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.
authors.forename: Eun Byul
authors.initials: EB
authors.lastname: Cho
authors.forename: Hoon
authors.initials: H
authors.lastname: Park
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Park
authors.forename: In Ho
authors.initials: IH
authors.lastname: Kwon
authors.forename: Sang Seok
authors.initials: SS
authors.lastname: Kim
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Kwang Joong
authors.initials: KJ
authors.lastname: Kim
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Park
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001706:Biopsy; D003094:Collagen / Q000528:radiation effects / Q000648:ultrastructure; D007150:Immunohistochemistry; D008027:Light; D008297:Male; D008854:Microscopy, Electron; D010789:Phototherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000528:radiation effects* / Q000648:ultrastructure; D015595:Skin Aging / Q000528:radiation effects
chemical_list: D003094:Collagen