title: Prevention of adhesion to prosthetic mesh: comparison of oxidized generated cellulose, polyethylene glycol and hylan G-F 20.
abstract: BACKGROUND
  The aim of this study was to investigate the impact of oxidized generated cellulose, polyethylene glycol and hylan G-F 20 on adhesion formation, fibrosis and inflammation after repair of abdominal wall defect with polypropylene mesh in an animal model.
  
  
  METHODS
  Forty rats were divided into four groups and abdominal wall defect was established. The defect was repaired with polypropylene mesh alone (control group), polypropylene mesh and hylan G-F 20 as adhesion barrier, polypropylene mesh and oxidized generated cellulose as adhesion barrier, or polypropylene mesh and polyethylene glycol as adhesion barrier in Groups I, II, III, and IV, respectively. Rats were sacrificed on the 14th day in all groups.
  
  
  RESULTS
  A comparison of the groups in terms of macroscopic adhesion scores revealed statistically significant differences between the groups using an adhesion barrier and the control group. Severe fibroblast proliferation was seen in the control group and mild fibroblast proliferation was seen in polyethylene glycol group.
  
  
  CONCLUSIONS
  Polyethylene glycol is an effective adhesion prevention barrier. Laparoscopic surgery has become the standard method in most of the surgical field. With its laparoscopic apparatus, polyethylene glycol allows easy application on the damaged surface.
authors.affiliation: Department of General Surgery Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ediz
authors.initials: E
authors.lastname: Altınlı
authors.forename: Aziz
authors.initials: A
authors.lastname: Sümer
authors.forename: Neşet
authors.initials: N
authors.lastname: Köksal
authors.forename: Ender
authors.initials: E
authors.lastname: Onur
authors.forename: Serkan
authors.initials: S
authors.lastname: Senger
authors.forename: Ersan
authors.initials: E
authors.lastname: Eroğlu
authors.forename: Atilla
authors.initials: A
authors.lastname: Celik
authors.forename: Gülistan
authors.initials: G
authors.lastname: Gümrükçü
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D006555:Hernia, Ventral / Q000473:pathology / Q000601:surgery*; D006820:Hyaluronic Acid / Q000031:analogs & derivatives; D008297:Male; D011092:Polyethylene Glycols; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; C049816:hylan; D011092:Polyethylene Glycols; D006820:Hyaluronic Acid