title: Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.
abstract: An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively. bla(CIA-1)-like genes were detected from clinical isolates. In addition to the metallo-β-lactamase IND of Ambler class B, C. indologenes has a class A ESBL gene, bla(CIA-1), located on the chromosome.
authors.affiliation: Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan. ggatcc@shinshu-u.ac.jp
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Mika
authors.initials: M
authors.lastname: Nagata
authors.forename: Nau
authors.initials: N
authors.lastname: Ishimine
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Eiko
authors.initials: E
authors.lastname: Hidaka
authors.forename: Eriko
authors.initials: E
authors.lastname: Kasuga
authors.forename: Kazuki
authors.initials: K
authors.lastname: Horiuchi
authors.forename: Kozue
authors.initials: K
authors.lastname: Oana
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Takayuki
authors.initials: T
authors.lastname: Honda
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002876:Chromosomes, Bacterial / Q000235:genetics; D045247:Chryseobacterium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D003001:Cloning, Molecular; D004926:Escherichia coli; D045826:Flavobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000145:classification / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D001618:beta-Lactamases
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