title: First danish single-institution experience with radical prostatectomy: biochemical outcome in 1200 consecutive patients.
abstract: Radical retropubic prostatectomy (RRP) as intended curative therapy for patients with clinically localized prostate cancer (PC) was initiated in 1995 in Denmark. This paper reports single-institution results from the first 1200 consecutive patients operated during a 15-year period. Median age at surgery was 63 years. Median PSA was 9 ng/mL. Palpable tumors (≤cT2) were present in 48% of patients. Gleason score at biopsy was ≤7 for 85% of patients. In sixty-five percent of patients, histopathology revealed localized PCa after RRP. Positive surgical margins were found in 39.2% of the cases. Biochemical recurrence (BR) occurred for 214 (18%) of patients. The estimated biochemical recurrence free survival (BRFS) was 71.7% and 63.2% after 5 and 10 years, respectively. When patients were stratified according to the D'Amico criteria, BRFS after 10 years was 75.3%, 59.7%, and 39.3% for low-, medium- and high-risk patients, respectively. In univariate analysis, clinical stage, PSA at diagnosis and type of surgery were significant predictors of BR. In multivariate analysis, Gleason score > 7, PSA > 10, and higher clinical stage were significant predictors of BR. Early Danish results in a population not subjected to screening demonstrate BRFS rates comparable with earlier reports from the prescreening era.
authors.affiliation: Department of Urology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Afsnit 2112, 2100 Copenhagen Ø, Denmark.
authors.forename: M Andreas
authors.initials: MA
authors.lastname: Røder
authors.forename: Kasper D
authors.initials: KD
authors.lastname: Berg
authors.forename: Lisa
authors.initials: L
authors.lastname: Gruschy
authors.forename: Klaus
authors.initials: K
authors.lastname: Brasso
authors.forename: Peter
authors.initials: P
authors.lastname: Iversen
references.citation: Urology. 2007 Nov;70(5):931-5
references.pmid: 18068450
references.citation: J Urol. 1995 Aug;154(2 Pt 1):429-34
references.pmid: 7541860
references.citation: J Natl Cancer Inst. 1998 May 20;90(10):766-71
references.pmid: 9605647
references.citation: Am J Surg Pathol. 1994 Oct;18(10):979-91
references.pmid: 7522415
references.citation: Ugeskr Laeger. 2009 Apr 27;171(18):1492-6
references.pmid: 19419627
references.citation: N Engl J Med. 2002 Sep 12;347(11):781-9
references.pmid: 12226148
references.citation: J Urol. 1994 Nov;152(5 Pt 2):1850-7
references.pmid: 7523733
references.citation: JAMA. 1998 Sep 16;280(11):969-74
references.pmid: 9749478
references.citation: J Urol. 2001 Dec;166(6):2185-8
references.pmid: 11696732
references.citation: J Urol. 2005 Apr;173(4):1126-31
references.pmid: 15758720
references.citation: Ugeskr Laeger. 2007 Jan 8;169(2):129-32
references.pmid: 17227660
references.citation: J Urol. 2008 Apr;179(4):1354-60; discussion 1360-1
references.pmid: 18289596
references.citation: BJU Int. 2002 Oct;90(6):561-6
references.pmid: 12230618
references.citation: N Engl J Med. 2005 May 12;352(19):1977-84
references.pmid: 15888698
references.citation: J Urol. 2002 Feb;167(2 Pt 1):528-34
references.pmid: 11792912
references.citation: Cancer. 2002 Jul 15;95(2):281-6
references.pmid: 12124827
references.citation: J Urol. 2001 Jan;165(1):119-25
references.pmid: 11125379
references.citation: Ugeskr Laeger. 2007 May 14;169(20):1883-6
references.pmid: 17553361
references.citation: JAMA. 1996 Aug 28;276(8):615-9
references.pmid: 8773633
references.citation: Prostate Suppl. 1994;5:9-14
references.pmid: 7513532
references.citation: Ugeskr Laeger. 2001 Oct 8;163(41):5669-73
references.pmid: 11665470