title: [Blood stream infections during agranulocytosis period after hematopoietic stem cell transplantation in one single center].
abstract: OBJECTIVE
  To analyze the epidemiologic features of blood stream infection (BSI) during the period of agranulocytosis after hematopoietic stem cell transplantation (HSCT) in our hospital, and provide the basis for the empirical therapy.
  
  
  METHODS
  The consecutive hematopoietic stem cell transplantation recipients conducted between January 2008 and October 2010 were studied retrospectively, to identify the current incidence, etiology for BSI and associated mortality during the period of agranulocytosis.
  
  
  RESULTS
  Totally 75 patients were diagnosed as BSI. The incidence of BSI was 9.6% (75/784) in HSCT during the period of agranulocytosis, 17.0% (75/441) in febrile patients. The pathogen testing showed that 64.4% were G(-) bacteria, 30.1% were G(+) bacterial and 5.5% were fungi. All G(-) bacteria except one were sensitive to carbapenems; all G(+) bacteria except one were sensitive to vancomycin. Among the 75 patients, 9 (12.0%) experienced septic shock and 5 (6.7%) died.
  
  
  CONCLUSIONS
  The pathogens of the BSI in the cohort are G(-) bacteria, followed by G(+) bacteria and fungi. Carbapenems and vancomycin are the first drugs for the experiential therapy.
authors.affiliation: Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Han
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Kai-yan
authors.initials: KY
authors.lastname: Liu
authors.forename: Dai-hong
authors.initials: DH
authors.lastname: Liu
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Feng-rong
authors.initials: FR
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000380:Agranulocytosis / Q000188:drug therapy / Q000382:microbiology*; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D005260:Female; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007239:Infections / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult