title: A new antifungal coumarin from Clausena excavata.
abstract: A new γ-lactone coumarin, named as excavarin-A, showing antifungal activity was isolated from the leaves of Clausena excavata by bioassay guided fractionation method. The structure was elucidated by spectroscopic data analysis and identified as 7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy) coumarin. Minimum inhibitory concentration (MIC) was determined against fifteen fungal strains pathogenic against plants and human. The least MIC was recorded against the human pathogen, Candida tropicalis and the plant pathogens Rhizoctonia solani and Sclerotinia sclerotiorum. Antifungal activities against the human pathogens, Aspergillus fumigatus and Mucor circinelloides and plant pathogens, Colletotrichum gloeosporioides, Lasiodiplodia theobromae, Fusarium oxysporum and Rhizopus stolonifer were stronger than that of the standard antimicrobials.
authors.affiliation: Department of Biotechnology, North Bengal University, Dist.-Darjeeling, Siliguri-734013, India.
authors.forename: Ramashish
authors.initials: R
authors.lastname: Kumar
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Saha
authors.forename: Dipanwita
authors.initials: D
authors.lastname: Saha
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D054700:Clausena / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000494:pharmacology; D015394:Molecular Structure; D009761:Nystatin / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C571382:7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy); D000935:Antifungal Agents; D001562:Benzimidazoles; D002219:Carbamates; D003374:Coumarins; D005659:Fungicides, Industrial; D010936:Plant Extracts; D009761:Nystatin; C006698:carbendazim