title: Extrusion printed polymer structures: a facile and versatile approach to tailored drug delivery platforms.
abstract: A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through the spatial distribution of drug within the printed 3-dimensional structures is demonstrated. The fabricated configurations were characterised by optical microscopy and SEM to evaluate surface morphology. The results clearly demonstrate the successful encapsulation of dexamethasone within a laminated PLGA:PVA structure. The resulting drug release profiles from the structures show a two stage release profile with distinctly different release rates and minimal initial burst release observed. Dexamethasone release was monitored over a 4-month period. This approach clearly demonstrates that the extrusion printing technique provides a facile and versatile approach to fabrication of novel drug delivery platforms.
authors.affiliation: Department of Chemistry and Centre for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Parawee
authors.initials: P
authors.lastname: Rattanakit
authors.forename: Simon E
authors.initials: SE
authors.lastname: Moulton
authors.forename: Karen S
authors.initials: KS
authors.lastname: Santiago
authors.forename: Saisunee
authors.initials: S
authors.lastname: Liawruangrath
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Wallace
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; C004180:dexamethasone 21-phosphate; D019344:Lactic Acid; D003907:Dexamethasone; D011142:Polyvinyl Alcohol