title: Evaluation of the anticancer activities of thioflavanone and thioflavone             in human breast cancer cell lines.
abstract: This study investigated the anticancer effects of thioflavanone and thioflavone in the MCF-7, MDA-MB-231 and MDA-MB-453 human breast cancer cell lines. Cells were treated with either thioflavanone or thioflavone from 1 to 100 µM for 24 h, and their anti-proliferative activity and cytotoxicity was determined. Thioflavanone and thioflavone possessed similar anti-proliferative activities; their IC50 values were 62-89 and 74-128 µM, respectively, although the cytotoxicity of thioflavanone was significantly higher and occurred in a dose-dependent manner. Taken together, these results suggest that thioflavanone significantly inhibits cellular proliferation with weak cytotoxicity to a greater extent than thioflavone, and induces apoptosis in human breast cancer cell lines. Moreover, thioflavanone, but not thioflavone, induces apoptosis via p53-dependent expression of Bax.
authors.affiliation: Plant Resources Research Institute, Duksung Women's University,                     Tobong-ku, Seoul 132-714, Republic of Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Choi
authors.forename: Jae In
authors.initials: JI
authors.lastname: Lee
authors.forename: Gun-Hee
authors.initials: GH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D016466:CHO Cells; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006224:Cricetinae; D005260:Female; D044950:Flavanones / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity*; D047309:Flavones / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones; D047309:Flavones; C571254:thioflavanone; C571255:thioflavone