title: Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107.
abstract: Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin-related compounds. They represent promising compounds to treat infections caused by multiresistant Gram-positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure-activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D (1)H NMR spectra, high-resolution 3D structures are determined using molecular dynamics simulations.
authors.affiliation: Organic and Industrial Chemistry Department, University of Milano, Milan, Italy. francesca.vasile@unimi.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Vasile
authors.forename: Donatella
authors.initials: D
authors.lastname: Potenza
authors.forename: Barbara
authors.initials: B
authors.lastname: Marsiglia
authors.forename: Sonia
authors.initials: S
authors.lastname: Maffioli
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000595:Amino Acid Sequence; D001430:Bacteriocins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D001430:Bacteriocins; D010455:Peptides; C528150:microbisporicin; C520832:planosporicin