title: Characterization of neuritin as a novel angiogenic factor.
abstract: Neuritin (NRN1), a neurotrophic factor, plays an important role in neurite growth and neuronal survival. In this study, we identify a new function of neuritin as a novel angiogenic factor in vitro and in vivo. Recombinant neuritin protein had no effect on the proliferation and adhesion of human umbilical vein endothelial cells (HUVEC), but it dose-dependently increased endothelial cell migration. Furthermore, overexpression of neuritin significantly promoted tumor angiogenesis, and surprisingly, it inhibited tumor growth in a xenograft tumor model. Thus, our results indicate that neuritin may act as an important angiogenic factor and serve as a potential target for cancer therapy.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China.
authors.forename: Dingding
authors.initials: D
authors.lastname: Han
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.forename: Guoqing
authors.initials: G
authors.lastname: Liu
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.forename: Guoqing
authors.initials: G
authors.lastname: Ji
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.forename: Long
authors.initials: L
authors.lastname: Yu
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D058851:GPI-Linked Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D043925:Angiogenesis Inducing Agents; D058851:GPI-Linked Proteins; C484539:NRN1 protein, human; D009479:Neuropeptides; D011994:Recombinant Proteins