title: MRI as a tool for evaluation of oral controlled release dosage forms.
abstract: The magnetic resonance imaging (MRI) studies of controlled-release (CR) dosage forms can be roughly divided into two groups. The first comprises studies performed in static conditions (small solvent volumes and ambient temperature). Such studies have provided insight into molecular phenomena in hydrating polymeric matrices. The second group covers research performed in dynamic conditions (medium flow or stirring) related to drug dissolution. An important issue is supplementation of the MRI results with data obtained by complementary techniques, such as X-ray microtomography (μCT). As we discuss here, an understanding of the mechanism underlying the release of the drug from the dosage form will lead to the development of detailed, molecularly defined, CR dosage forms.
authors.affiliation: Department of Pharmaceutical Technology and Biopharmaceutics, Pharmaceutical Faculty, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Kraków, Poland. mfdorozy@cyf-kr.edu.pl
authors.forename: Przemysław P
authors.initials: PP
authors.lastname: Dorożyński
authors.forename: Piotr
authors.initials: P
authors.lastname: Kulinowski
authors.forename: Anna
authors.initials: A
authors.lastname: Młynarczyk
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Stanisz
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D015195:Drug Design; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011108:Polymers; D012997:Solvents