title: Longitudinal analyses of polysomnographic variables, serum androgens, and parameters of glucose metabolism in obese adolescents with polycystic ovarian syndrome.
abstract: OBJECTIVE
  The prevalence of obstructive sleep apnea syndrome (OSAS) is clearly increased in adults with polycystic ovarian syndrome (PCOS), whereas OSAS does not seem to be frequent in adolescents with PCOS, pointing towards the fact that some patients with PCOS develop OSAS in the further course of the disease. We therefore aimed to analyze the changes of polysomnographic variables in obese adolescents with PCOS in a longitudinal analysis.
  
  
  METHODS
  Fifteen adolescents with PCOS (age 15.3 years ± 1.2, BMI 32.9 kg/m(2) ± 6.4, SDS-BMI 2.5 ± 0.8) underwent overnight 12-channel polysomnography at baseline and after a mean duration of 28 ± 6 months (age 17.8 years ± 1.1, BMI 32.7 kg/m(2) ± 7.0, SDS-BMI 2.1 ± 0.9). After performing the initial polysomnography, we treated hyperandrogenemia and insulin resistance in the study group. We determined parameters of body weight/body composition, parameters of glucose metabolism, and serum androgens in all patients at baseline and follow-up. At follow-up, we compared the polysomnographic variables of the study group to those of healthy female adults.
  
  
  RESULTS
  The polysomnographic variables, the parameters of body weight/body composition, and the parameters of glucose metabolism in the study group did not change significantly during the observation period. The serum levels of total testosterone and sex hormone binding globulin increased significantly, whereas free androgen index decreased significantly. At follow-up, the polysomnographic variables of the study group did not differ from those of healthy female adults.
  
  
  CONCLUSIONS
  OSAS does not seem to develop in adolescents with PCOS being treated for hyperandrogenism and insulin resistance. The pathogenesis of OSAS in PCOS needs to be examined in larger controlled studies.
authors.affiliation: Vestische Kinder- und Jugendklinik, University of Witten/Herdecke, Dr.-Friedrich-Steiner-Str. 5, 45711, Datteln, Germany. GandM@web.de
authors.forename: Gideon
authors.initials: G
authors.lastname: de Sousa
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schlüter
authors.forename: Thomas
authors.initials: T
authors.lastname: Menke
authors.forename: Eckardt
authors.initials: E
authors.lastname: Trowitzsch
authors.forename: Werner
authors.initials: W
authors.lastname: Andler
authors.forename: Thomas
authors.initials: T
authors.lastname: Reinehr
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood*; D001521:Behavior Therapy; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003131:Combined Modality Therapy; D015897:Comorbidity; D015444:Exercise; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008019:Life Style; D008137:Longitudinal Studies; D044623:Nutrition Therapy; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy
chemical_list: D000728:Androgens; D001786:Blood Glucose
references.citation: J Clin Endocrinol Metab. 2006 Jan;91(1):36-42
references.pmid: 16219719
references.citation: Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1527-32
references.pmid: 10228121
references.citation: J Clin Endocrinol Metab. 2001 Feb;86(2):517-20
references.pmid: 11158002
references.citation: Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10
references.pmid: 11422885
references.citation: Sleep Breath. 2012 Mar;16(1):169-75
references.pmid: 21221823
references.citation: Circulation. 2002 Dec 17;106(25):3143-421
references.pmid: 12485966
references.citation: Sleep Breath. 2010 Feb;14(1):33-8
references.pmid: 19585163
references.citation: Trends Endocrinol Metab. 2003 Oct;14(8):365-70
references.pmid: 14516934
references.citation: Am J Clin Nutr. 2006 Sep;84(3):490-6
references.pmid: 16960161
references.citation: J Clin Endocrinol Metab. 2005 Oct;90(10):5588-95
references.pmid: 16014405
references.citation: J Clin Invest. 2000 Aug;106(4):473-81
references.pmid: 10953022
references.citation: J Clin Endocrinol Metab. 1998 Sep;83(9):3078-82
references.pmid: 9745406
references.citation: BMJ. 2000 May 6;320(7244):1240-3
references.pmid: 10797032
references.citation: Sleep Med. 2002 Sep;3(5):401-4
references.pmid: 14592171
references.citation: Sleep Breath. 2012 Sep;16(3):695-701
references.pmid: 21796489
references.citation: Eur J Clin Nutr. 1990 Jan;44(1):45-60
references.pmid: 2354692
references.citation: Int J Obes (Lond). 2007 Jul;31(7):1074-7
references.pmid: 17471300
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):1175-80
references.pmid: 11238505
references.citation: Obes Res. 2005 Jul;13(7):1175-9
references.pmid: 16076986
references.citation: J Sleep Res. 2011 Sep;20(3):472-8
references.pmid: 21199038
references.citation: Hum Biol. 1988 Oct;60(5):709-23
references.pmid: 3224965
references.citation: J Clin Endocrinol Metab. 2008 Oct;93(10):3878-84
references.pmid: 18647805
references.citation: N Engl J Med. 2005 Nov 10;353(19):2034-41
references.pmid: 16282178
references.citation: J Nutr. 2001 Feb;131(2):354S-60S
references.pmid: 11160560
references.citation: Sleep Breath. 2007 Dec;11(4):233-7
references.pmid: 17541663
references.citation: Sleep. 1992 Apr;15(2):173-84
references.pmid: 11032543
references.citation: N Engl J Med. 2005 Mar 24;352(12):1223-36
references.pmid: 15788499
references.citation: Sleep Breath. 2012 Mar;16(1):123-33
references.pmid: 21213062
references.citation: Sleep. 1999 Aug 1;22(5):667-89
references.pmid: 10450601
references.citation: Sleep Breath. 2012 Dec;16(4):1091-5
references.pmid: 22033627
references.citation: Diabetologia. 1985 Jul;28(7):412-9
references.pmid: 3899825