title: Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.
abstract: The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations. The limited number of studies assessing its significance in Asian populations has been somewhat conflicting. We performed a genetic association study of 51 tagging, genome-wide association studies, and imputed single nucleotide polymorphisms with 12 measures of adiposity and skeletal robustness in two Samoan populations of Polynesia. We included 465 and 624 unrelated American Samoan and Samoan individuals, respectively; these populations derive from a single genetic background traced to Southeast Asia and represent one sociocultural unit, although they are economically disparate with distinct environmental exposures. American Samoans were significantly larger than Samoans in all measures of obesity and most measures of skeletal robustness. In separate analyses of American Samoa and Samoa, we found a total of 36 nominal associations between FTO variants and skeletal and obesity measures. The preponderance of these nominal associations (32 of 36) was observed in the Samoan population, and predominantly with skeletal rather than fat mass measures (28 of 36). All significance disappeared, however, following corrections for multiple testing. Based on these findings, it could be surmised that FTO is not likely a major obesity locus in Polynesian populations.
authors.affiliation: Department of Environmental Health, University of Cincinnati College of Medicine, OH, USA.
authors.forename: Rebekah
authors.initials: R
authors.lastname: Karns
authors.forename: Satupaitea
authors.initials: S
authors.lastname: Viali
authors.forename: John
authors.initials: J
authors.lastname: Tuitele
authors.forename: Guangyun
authors.initials: G
authors.lastname: Sun
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Weeks
authors.forename: Stephen T
authors.initials: ST
authors.lastname: McGarvey
authors.forename: Ranjan
authors.initials: R
authors.lastname: Deka
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D018948:American Samoa; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D018947:Samoa
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
references.citation: Diabetes. 2008 Jan;57(1):264-8
references.pmid: 17959933
references.citation: PLoS Genet. 2007 Jul;3(7):e115
references.pmid: 17658951
references.citation: Science. 2007 May 11;316(5826):889-94
references.pmid: 17434869
references.citation: Nat Genet. 2008 Jun;40(6):768-75
references.pmid: 18454148
references.citation: Hum Genomics. 2004 Aug;1(5):327-34
references.pmid: 15588493
references.citation: Obesity (Silver Spring). 2008 Sep;16(9):2187-9
references.pmid: 18551112
references.citation: Diabetes Metab Res Rev. 2010 Feb;26(2):128-32
references.pmid: 20186840
references.citation: Annu Rev Genomics Hum Genet. 2009;10:387-406
references.pmid: 19715440
references.citation: J Hum Genet. 2007;52(12):1031-1035
references.pmid: 17928949
references.citation: Nat Genet. 2007 Jun;39(6):724-6
references.pmid: 17496892
references.citation: Diabetologia. 2009 Feb;52(2):247-52
references.pmid: 19005641
references.citation: Am J Clin Nutr. 1991 Jun;53(6 Suppl):1586S-1594S
references.pmid: 2031491
references.citation: Am J Hum Genet. 2011 Feb 11;88(2):239-47
references.pmid: 21295281
references.citation: Am J Hum Genet. 2004 Jan;74(1):106-20
references.pmid: 14681826
references.citation: Am J Hum Biol. 2006 Jan;18(1):112-22
references.pmid: 16378333
references.citation: BMC Med Genet. 2010 Sep 22;11:136
references.pmid: 20858286
references.citation: Pac Health Dialog. 2001 Mar;8(1):157-62
references.pmid: 12017817
references.citation: Hum Biol. 1994 Oct;66(5):805-22
references.pmid: 8001911
references.citation: Diabetes. 2008 Oct;57(10):2851-7
references.pmid: 18599522
references.citation: Am J Hum Genet. 2005 May;76(5):887-93
references.pmid: 15789306
references.citation: Bioinformatics. 2005 Jan 15;21(2):263-5
references.pmid: 15297300
references.citation: Nat Rev Genet. 2010 Jul;11(7):499-511
references.pmid: 20517342
references.citation: PLoS One. 2008 Mar 12;3(3):e1746
references.pmid: 18335027
references.citation: Am J Hum Genet. 2007 Sep;81(3):559-75
references.pmid: 17701901
references.citation: Science. 2006 Apr 14;312(5771):279-83
references.pmid: 16614226
references.citation: Diabetes. 2008 Aug;57(8):2226-33
references.pmid: 18469204
references.citation: Nat Genet. 2008 Jun;40(6):716-8
references.pmid: 18454146
references.citation: J Am Diet Assoc. 1999 Feb;99(2):184-90
references.pmid: 9972185
references.citation: Int J Obes Relat Metab Disord. 1999 Nov;23(11):1178-83
references.pmid: 10578208
references.citation: Nat Genet. 2009 Jan;41(1):18-24
references.pmid: 19079260