title: [New antithrombotic drugs for the treatment of venous thromboembolism].
abstract: Numerous newer anticoagulants are under advanced clinical development for the treatment of venous thromboembolism. These new drugs specifically inhibit activated factors II or X, with predictable effects and no need for dose modification and laboratory monitoring. The main direct activated factor X (FXa) inhibitors are rivaroxaban, apixaban and edoxaban. They are taken orally once or twice per day. Dabigatran is the main inhibitor of activated factor II (IIa) and is administered orally once daily. Dabigatran and rivaroxaban are already licensed for the prevention of thromboembolic events following major orthopedic surgery such as total hip and knee replacement. They will probably soon be authorized for the treatment of venous thromboembolism, if they both confirm their efficacy and safety, and can demonstrate their cost-effectiveness. However, only rivaroxaban has been tested as a stand-alone treatment, whereas dabigatran was compared to vitamin K antagonism after a standard treatment regimen based on heparin or its derivates.
authors.affiliation: Groupe de Recherche sur la Thrombose, EA 3065, Université de Saint-Étienne, Jean-Monnet, 42000 Saint-Étienne, France. laurent.bertoletti@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Bertoletti
authors.forename: P
authors.initials: P
authors.lastname: Mismetti
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods; D015507:Drugs, Investigational / Q000138:chemical synthesis / Q000627:therapeutic use*; D015951:Factor Xa / Q000276:immunology; D065427:Factor Xa Inhibitors; D006801:Humans; D008954:Models, Biological; D011516:Prothrombin / Q000037:antagonists & inhibitors / Q000276:immunology; D012106:Research / Q000639:trends; D054556:Venous Thromboembolism / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D015507:Drugs, Investigational; D065427:Factor Xa Inhibitors; D011516:Prothrombin; C025337:Factor IIa; D015951:Factor Xa