title: Hepatitis C and hepatitis B seroprevalence and associated risk factors in hemodialysis patients in Guilan province, north of Iran: HCV and HBV seroprevalence in hemodialysis patients.
abstract: BACKGROUND
  Hepatitis C virus (HCV) and hepatitis B virus (HBV) infection are especially problematic in patients with end-stage renal disease who are undergoing hemodialysis (HD).
  
  
  OBJECTIVE
  To determine the prevalence of HCV and HBV infection in HD population in Guilan, north of Iran.
  
  
  METHODS
  In a cross-sectional study, from May to September 2009, in 11 different hemodialysis units in Guilan province, North of Iran, clinical data such as age, gender, duration of dialysis, HBsAg and anti-HCV antibody of 514 HD patients were recorded. Patients with positive antibodies against HCV were tested for HCV RNA.
  
  
  RESULTS
  From 514 patients, 286 (55.64%) were male. 61 (11.9%) patients were anti-HCV-positive and 31 (50.8%) were HCV PCR-positive. There was significant relationship between HCV Ab-positivity with gender and HD duration (p < 0.05). There was significant difference between the mean HD duration in anti-HCV-positive and anti-HCV-negative patients (p < 0.05). Also, significant relationship was found between HCV RNA-positivity with gender and HD duration (p < 0.05). Seven (1.4%) patients were positive for HBsAg. Two (0.38 %) were found positive for both HBsAg and anti-HCV antibody.
  
  
  CONCLUSIONS
  There is low a prevalence of HCV and HBV in HD patients in our region. The rate can be decreased by HBV vaccination of end-stage renal disease patients before setting chronic HD, antiviral treatment and isolation of infected individuals.
authors.affiliation: Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Joukar
authors.forename: Sepiedeh
authors.initials: S
authors.lastname: Besharati
authors.forename: Hasan
authors.initials: H
authors.lastname: Mirpour
authors.forename: Fariborz
authors.initials: F
authors.lastname: Mansour-Ghanaei
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