title: Clinical efficacy of home-use blue-light therapy for mild-to moderate acne.
abstract: BACKGROUND
  Blue-light light-emitting diode (LED) therapy has become widely used for the treatment of inflammatory acne. In this study we evaluated the efficacy of a home use blue-light LED application in improving lesions and shortening their time to clearance.
  
  
  METHODS
  This was an IRB approved randomized self-control study. For each patient (n = 30), 2 similar lesions, one of each side of the face were chosen for treatment with either a blue-light LED hand-held or sham device. Treatments (n = 4) were conducted twice daily in the clinic and lesions were followed-up till resolution. Reduction in blemishes size and erythema and the overall improvement were evaluated by both the physician and the patients. Time to lesion resolution was recorded.
  
  
  RESULTS
  There was a significant difference in the response of lesions to the blue-light LED application as opposed to the placebo in terms of reduction in lesion size and lesion erythema as well as the improvement in the overall skin condition (p < 0.025). Signs of improvement were observed as early as post 2 treatments. Time to resolution was significantly shorter for the blue-light LED therapy.
  
  
  CONCLUSIONS
  The results support the effectiveness of using blue-light LED therapy on a daily basis for better improvement and faster resolution of inflammatory acne lesions.
authors.affiliation: Gold Skin Care Center, Department of Dermatology, School of Nursing, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN 37215, USA. goldskin@goldskincare.com
authors.forename: Michael H
authors.initials: MH
authors.lastname: Gold
authors.forename: Whitney
authors.initials: W
authors.lastname: Sensing
authors.forename: Julie A
authors.initials: JA
authors.lastname: Biron
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology / Q000628:therapy*; D000328:Adult; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D010789:Phototherapy / Q000295:instrumentation; D011446:Prospective Studies; D012646:Self Administration; D012720:Severity of Illness Index