title: Striatal hypermetabolism in limbic encephalitis.
abstract: Striatal hypermetabolism on 18FDG-PET scan is a neuroradiological finding that has been described in association with autoimmune disorders such as Sydenham chorea, lupus or antiphospholipid syndrome. Here, we report three patients with non-paraneoplastic limbic encephalitis characterized by 18FDG-PET hypermetabolism of both striata, in contrast with diffuse hypometabolism in the rest of the brain. All patients developed subacute dementia, and antibodies to voltage-gated potassium channels were found in all cases. Brain metabolism and neurological status improved within a few months of immunosuppressive therapy. The finding of striatal hypermetabolism on 18FDG-PET images could thus be highly indicative of limbic encephalitis associated with anti-neuropil antibodies. It could be of significant help in the diagnosis of this rare and treatable condition, and may also provide a useful marker of disease outcome.
authors.affiliation: Pôle de Neurosciences Cliniques, CHU Timone, Marseille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Rey
authors.forename: Lejla
authors.initials: L
authors.lastname: Koric
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.forename: Olivier
authors.initials: O
authors.lastname: Felician
authors.forename: Elsa
authors.initials: E
authors.lastname: Kaphan
authors.forename: José
authors.initials: J
authors.lastname: Boucraut
authors.forename: Mathieu
authors.initials: M
authors.lastname: Ceccaldi
mesh_terms: D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D020363:Limbic Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18
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