title: Sensory handedness is not reflected in cortical responses after basic nerve stimulation: a MEG study.
abstract: Motor dominance is well established, but sensory dominance is much less clear. We therefore studied the cortical evoked magnetic fields using magnetoencephalography (MEG) in a group of 20 healthy right handed subjects in order to examine whether standard electrical stimulation of the median and ulnar nerve demonstrated sensory lateralization. The global field power (GFP) curves, as an indication of cortical activation, did not depict sensory lateralization to the dominant left hemisphere. Comparison of the M20, M30, and M70 peak latencies and GFP values exhibited no statistical differences between the hemispheres, indicating no sensory hemispherical dominance at these latencies for each nerve. Field maps at these latencies presented a first and second polarity reversal for both median and ulnar stimulation. Spatial dipole position parameters did not reveal statistical left-right differences at the M20, M30 and M70 peaks for both nerves. Neither did the dipolar strengths at M20, M30 and M70 show a statistical left-right difference for both nerves. Finally, the Laterality Indices of the M20, M30 and M70 strengths did not indicate complete lateralization to one of the hemispheres. After electrical median and ulnar nerve stimulation no evidence was found for sensory hand dominance in brain responses of either hand, as measured by MEG. The results can provide a new assessment of patients with sensory dysfunctions or perceptual distortion when sensory dominance occurs way beyond the estimated norm.
authors.affiliation: Center for Higher Brain Functions, Capital Medical University, Beijing, China. ac@ccmu.edu.cn
authors.forename: Andrew C N
authors.initials: AC
authors.lastname: Chen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Theuvenet
authors.forename: Jan C
authors.initials: JC
authors.lastname: de Munck
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Peters
authors.forename: Jan M
authors.initials: JM
authors.lastname: van Ree
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Lopes da Silva
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006225:Hand / Q000294:innervation / Q000502:physiology; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D012677:Sensation / Q000502:physiology*; D014459:Ulnar Nerve / Q000502:physiology