title: Vascular involvement in systemic sclerosis (scleroderma).
abstract: Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to treat the vascular manifestations of SSc are discussed. Also discussed is how the hallmark pathologies (ie, how autoimmunity, vasculopathy, and fibrosis of the disease) might be effected and interconnected with modulatory input from lysophospholipids, sphingosine 1-phosphate, and lysophosphatidic acid.
authors.affiliation: Division of Connective Tissue Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Debendra
authors.initials: D
authors.lastname: Pattanaik
authors.forename: Monica
authors.initials: M
authors.lastname: Brown
authors.forename: Arnold E
authors.initials: AE
authors.lastname: Postlethwaite
references.citation: Ann Med. 2005;37(1):2-12
references.pmid: 15902842
references.citation: Arthritis Rheum. 2004 Dec;50(12):3985-93
references.pmid: 15593188
references.citation: Arthritis Rheum. 2007 Oct;56(10):3459-67
references.pmid: 17907151
references.citation: J Exp Med. 2004 Mar 15;199(6):763-74
references.pmid: 15007093
references.citation: Lancet. 1982 Jan 9;1(8263):76-7
references.pmid: 6119495
references.citation: Ann Rheum Dis. 1993 Aug;52(8):564-9
references.pmid: 8215616
references.citation: J Rheumatol. 2001 Oct;28(10):2257-62
references.pmid: 11669166
references.citation: J Invest Dermatol. 2006 Apr;126(4):756-65
references.pmid: 16456536
references.citation: Drugs. 2001;61(12):1765-74; discussion 1775-6
references.pmid: 11693465
references.citation: Ann Rheum Dis. 2010 May;69(5):822-7
references.pmid: 19596691
references.citation: Ann Rheum Dis. 2008 Oct;67(10):1455-60
references.pmid: 18174219
references.citation: J Rheumatol. 2008 Sep;35(9):1830-7
references.pmid: 18634152
references.citation: Arthritis Rheum. 2010 Oct;62(10):3128-9; author reply 3129-30
references.pmid: 20597113
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L843-61
references.pmid: 18203815
references.citation: Thromb Haemost. 2003 Dec;90(6):993-1002
references.pmid: 14652629
references.citation: Reumatismo. 2009 Apr-Jun;61(2):90-7
references.pmid: 19633795
references.citation: Exp Eye Res. 2008 Oct;87(4):367-75
references.pmid: 18687328
references.citation: Am J Respir Crit Care Med. 2008 Mar 15;177(6):604-12
references.pmid: 18096710
references.citation: J Clin Invest. 1987 Apr;79(4):1285-8
references.pmid: 3470308
references.citation: J Lipid Res. 2009 Mar;50(3):556-564
references.pmid: 18955732
references.citation: Ann Intern Med. 1981 Apr;94(4 pt 1):482-4
references.pmid: 6782927
references.citation: Arthritis Rheum. 2004 Jun;50(6):1918-27
references.pmid: 15188368
references.citation: J Cutan Pathol. 2004 Jul;31(6):431-40
references.pmid: 15186431
references.citation: Lancet. 1993 Jul 10;342(8863):80-3
references.pmid: 8100913
references.citation: Arthritis Rheum. 2008 Dec;58(12):3902-12
references.pmid: 19035499
references.citation: Blood. 2009 Sep 24;114(13):2639-48
references.pmid: 19643985
references.citation: J Immunol. 2002 Apr 1;168(7):3649-59
references.pmid: 11907131
references.citation: J Rheumatol. 1993 Aug;20(8):1325-30
references.pmid: 8230013
references.citation: Lancet. 2004 Aug 14-20;364(9434):603-10
references.pmid: 15313361
references.citation: Clin Rheumatol. 1999;18(5):425-7
references.pmid: 10524561
references.citation: Ann Intern Med. 2006 Jul 18;145(2):152-3
references.pmid: 16847299
references.citation: Am J Transplant. 2005 Oct;5(10):2565-9
references.pmid: 16162209
references.citation: Arthritis Rheum. 2006 Jun;54(6):1961-73
references.pmid: 16736506
references.citation: Rheumatology (Oxford). 2005 May;44(5):587-96
references.pmid: 15741200
references.citation: Ann Rheum Dis. 2010 Jan;69 Suppl 1:i52-56
references.pmid: 19995745
references.citation: Nat Rev Rheumatol. 2010 May;6(5):269-78
references.pmid: 20386562
references.citation: Curr Opin Rheumatol. 2002 Nov;14(6):686-93
references.pmid: 12410092
references.citation: Drugs. 2007;67(4):517-25
references.pmid: 17352512
references.citation: Rheumatology (Oxford). 2005 Feb;44(2):145-50
references.pmid: 15546967
references.citation: Rheum Dis Clin North Am. 2008 Feb;34(1):41-55; vi
references.pmid: 18329531
references.citation: Hum Pathol. 1997 Apr;28(4):434-42
references.pmid: 9104943
references.citation: Cardiovasc Res. 2009 May 1;82(2):212-20
references.pmid: 19233865
references.citation: J Clin Invest. 1991 Jun;87(6):2147-52
references.pmid: 2040697
references.citation: Rheumatology (Oxford). 2008 Apr;47(4):464-6
references.pmid: 18263597
references.citation: Cochrane Database Syst Rev. 2000;(2):CD000953
references.pmid: 10796395
references.citation: J Rheumatol. 1992 Oct;19(10):1566-71
references.pmid: 1464869
references.citation: Medicine (Baltimore). 1999 Nov;78(6):382-5
references.pmid: 10575420
references.citation: Am J Respir Crit Care Med. 2003 Aug 15;168(4):487-93
references.pmid: 12773327
references.citation: Arthritis Rheum. 2007 Oct;56(10):3448-58
references.pmid: 17907150
references.citation: Clin Exp Rheumatol. 2003;21(3 Suppl 29):S9-14
references.pmid: 12889215
references.citation: Br J Dermatol. 1992 Jun;126(6):561-8
references.pmid: 1610706
references.citation: Nat Rev Rheumatol. 2010 Aug;6(8):453-60
references.pmid: 20585340
references.citation: Clin Exp Rheumatol. 2002 Sep-Oct;20(5):641-6
references.pmid: 12412194
references.citation: J Biol Chem. 2003 Oct 17;278(42):40967-72
references.pmid: 12881513
references.citation: Ann Intern Med. 2000 Oct 17;133(8):600-3
references.pmid: 11033587
references.citation: Arthritis Rheum. 2004 Jun;50(6):1721-33
references.pmid: 15188347
references.citation: Arthritis Rheum. 1998 Apr;41(4):670-7
references.pmid: 9550476
references.citation: Circ Res. 2004 May 28;94(10):1367-74
references.pmid: 15087420
references.citation: J Invest Dermatol. 1995 Aug;105(2):280-4
references.pmid: 7636314
references.citation: J Dermatol. 2010 Jan;37(1):54-70
references.pmid: 20175840
references.citation: Rheumatology (Oxford). 2006 Jun;45(6):676-84
references.pmid: 16399843
references.citation: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12319-24
references.pmid: 14530402
references.citation: J Immunol. 2010 May 1;184(9):4654-61
references.pmid: 20335527
references.citation: Chest. 2009 Nov;136(5):1211-1219
references.pmid: 19429720
references.citation: Hum Pathol. 2006 Feb;37(2):190-7
references.pmid: 16426919
references.citation: Ann Rheum Dis. 2009 May;68(5):620-8
references.pmid: 19147617
references.citation: Hum Pathol. 2007 Jun;38(6):893-902
references.pmid: 17376507
references.citation: Immunology. 2007 Sep;122(1):38-46
references.pmid: 17442023
references.citation: Am J Kidney Dis. 2001 Jun;37(6):1152-61
references.pmid: 11382683
references.citation: Front Biosci. 2002 Mar 01;7:d608-18
references.pmid: 11861221
references.citation: Lab Invest. 1996 Aug;75(2):281-9
references.pmid: 8765328
references.citation: Can J Physiol Pharmacol. 1995 Jul;73(7):1070-4
references.pmid: 8846403
references.citation: Arthritis Res. 2002;4(6):R11
references.pmid: 12453314
references.citation: Eur J Clin Invest. 2006 Sep;36 Suppl 3:10-5
references.pmid: 16919005
references.citation: J Vasc Res. 2001 Mar-Apr;38(2):113-9
references.pmid: 11316947
references.citation: Lab Invest. 2010 May;90(5):739-52
references.pmid: 20195245
references.citation: Arthritis Rheum. 2004 Apr;50(4):1296-304
references.pmid: 15077314
references.citation: Lab Invest. 1996 Feb;74(2):452-66
references.pmid: 8780163
references.citation: Int Rev Immunol. 1995;12(2-4):187-99
references.pmid: 7650421
references.citation: Circulation. 2006 Apr 18;113(15):1857-64
references.pmid: 16606791
references.citation: Arthritis Rheum. 2009 Mar;60(3):870-7
references.pmid: 19248104
references.citation: Ann Rheum Dis. 1993 Apr;52(4):272-7
references.pmid: 8484693
references.citation: J Invest Dermatol. 2010 Nov;130(11):2583-93
references.pmid: 20613770
references.citation: FASEB J. 2007 Sep;21(11):2970-9
references.pmid: 17470567
references.citation: Acta Derm Venereol. 2009;89(3):245-9
references.pmid: 19479119
references.citation: Ann N Y Acad Sci. 2001 Dec;947:93-109; discussion 109-11
references.pmid: 11795313
references.citation: J Clin Invest. 1992 Oct;90(4):1479-85
references.pmid: 1401080
references.citation: J Rheumatol. 2008 Sep;35(9):1801-8
references.pmid: 18709692
references.citation: Exp Cell Res. 2002 Nov 15;281(1):140-7
references.pmid: 12441137
references.citation: Clin Rheumatol. 2009 Sep;28(9):1121-5
references.pmid: 19437086
references.citation: Biochim Biophys Acta. 2008 Sep;1781(9):582-7
references.pmid: 18455518
references.citation: Br J Haematol. 1993 Aug;84(4):675-80
references.pmid: 8217827
references.citation: Expert Opin Investig Drugs. 2009 Jan;18(1):23-9
references.pmid: 19053879
references.citation: Br J Rheumatol. 1990 Apr;29(2):93-6
references.pmid: 2322780
references.citation: Cardiovasc Res. 1996 Oct;32(4):687-98
references.pmid: 8915187
references.citation: Clin Exp Rheumatol. 2003 May-Jun;21(3):403
references.pmid: 12846066
references.citation: J Rheumatol. 2007 Dec;34(12):2417-22
references.pmid: 17985403
references.citation: Ann Rheum Dis. 2006 Aug;65(8):1118-20
references.pmid: 16837498
references.citation: Arthritis Rheum. 2007 Nov;56(11):3837-46
references.pmid: 17968938
references.citation: Prostaglandins Other Lipid Mediat. 2001 Jun;65(2-3):73-83
references.pmid: 11403500
references.citation: Drugs. 2009 Oct 1;69(14):2005-24
references.pmid: 19747014
references.citation: Arthritis Rheum. 1998 Jun;41(6):1111-8
references.pmid: 9627022
references.citation: Br J Dermatol. 1996 Mar;134(3):399-406
references.pmid: 8731660
references.citation: Chest. 2004 Aug;126(2):420-7
references.pmid: 15302727
references.citation: J Exp Med. 1998 Oct 5;188(7):1359-68
references.pmid: 9763615
references.citation: Cardiovasc Res. 2009 May 1;82(2):303-12
references.pmid: 19228708
references.citation: Sci Transl Med. 2010 Mar 17;2(23):23ra20
references.pmid: 20375004
references.citation: Lancet. 2001 Oct 6;358(9288):1119-23
references.pmid: 11597664
references.citation: Discov Med. 2010 Aug;10(51):134-43
references.pmid: 20807474
references.citation: J Dermatol. 2010 Jan;37(1):3-10
references.pmid: 20175836
references.citation: Arthritis Rheum. 2006 Jun;54(6):1946-51
references.pmid: 16729283
references.citation: J Invest Dermatol. 2001 Aug;117(2):269-73
references.pmid: 11511304
references.citation: Ann Rheum Dis. 2007 Nov;66(11):1467-72
references.pmid: 17472992
references.citation: J Am Soc Nephrol. 2007 Dec;18(12):3110-8
references.pmid: 18003779
references.citation: Arthritis Rheum. 1998 Feb;41(2):327-34
references.pmid: 9485091
references.citation: Ann Intern Med. 1970 Aug;73(2):317-24
references.pmid: 4916764
references.citation: Mayo Clin Proc. 1985 Nov;60(11):763-71
references.pmid: 3903366
references.citation: Circulation. 2008 Nov 18;118(21):2156-65
references.pmid: 18981303
references.citation: Int Arch Allergy Immunol. 1998 Jul;116(3):188-95
references.pmid: 9693266
references.citation: Ann Rheum Dis. 2009 Feb;68(2):163-8
references.pmid: 18653485
references.citation: Br J Rheumatol. 1997 Oct;36(10):1045-50
references.pmid: 9374919
references.citation: Biochem J. 1996 Apr 15;315 ( Pt 2):549-54
references.pmid: 8615828
references.citation: N Engl J Med. 2005 Sep 29;353(13):1412-3
references.pmid: 16192491
references.citation: Mymensingh Med J. 2008 Jul;17(2):192-6
references.pmid: 18626457
references.citation: QJM. 2007 Aug;100(8):485-94
references.pmid: 17601770
references.citation: Medicine (Baltimore). 1974 Jan;53(1):1-46
references.pmid: 4808710
references.citation: J Clin Invest. 2005 Oct;115(10):2811-21
references.pmid: 16200212
references.citation: Heart. 2006 Jul;92(7):926-32
references.pmid: 16339813
references.citation: Arthritis Rheum. 1991 Aug;34(8):978-83
references.pmid: 1859492
references.citation: Rheum Dis Clin North Am. 2003 May;29(2):293-313
references.pmid: 12841296
references.citation: Clin Exp Immunol. 1987 Aug;69(2):375-84
references.pmid: 3498592
references.citation: Circulation. 2005 Nov 8;112(19):2980-5
references.pmid: 16275885
references.citation: Arthritis Res Ther. 2007;9 Suppl 2:S5
references.pmid: 17767743
references.citation: J Rheumatol. 1996 Apr;23(4):646-9
references.pmid: 8730120
references.citation: Ann Intern Med. 1990 Sep 1;113(5):352-7
references.pmid: 2382917
references.citation: Arthritis Rheum. 2008 Jul;58(7):2163-73
references.pmid: 18576347
references.citation: Nat Immunol. 2009 Jul;10(7):769-77
references.pmid: 19483717
references.citation: Arthritis Res Ther. 2005;7(5):R1113-23
references.pmid: 16207328
references.citation: Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v46-7
references.pmid: 18784143
references.citation: Arthritis Rheum. 2007 Jun;56(6):1994-2004
references.pmid: 17530639
references.citation: Life Sci. 2007 Sep 1;81(12):1009-15
references.pmid: 17850827
references.citation: Arthritis Rheum. 1999 Dec;42(12):2646-55
references.pmid: 10616013
references.citation: N Engl J Med. 2002 Mar 21;346(12):896-903
references.pmid: 11907289
references.citation: PLoS One. 2009 Jun 22;4(6):e5981
references.pmid: 19543397
references.citation: Expert Opin Pharmacother. 2010 Apr;11(5):789-806
references.pmid: 20210685
references.citation: J Heart Lung Transplant. 2010 Aug;29(8):873-80
references.pmid: 20471860
references.citation: Semin Arthritis Rheum. 2003 Apr;32(5):285-95
references.pmid: 12701039
references.citation: Rheum Dis Clin North Am. 2008 Feb;34(1):57-71; vi
references.pmid: 18329532
references.citation: PLoS One. 2008 Jul 16;3(7):e2696
references.pmid: 18648520
references.citation: Circ Res. 2003 Oct 17;93(8):783-90
references.pmid: 14500338
references.citation: Nature. 1988 Mar 31;332(6163):411-5
references.pmid: 2451132
references.citation: Arthritis Res Ther. 2007;9 Suppl 2:S3
references.pmid: 17767741
references.citation: Dermatology. 2009;219(2):171-3
references.pmid: 19590168
references.citation: Ann Rheum Dis. 2010 Aug;69(8):1475-8
references.pmid: 19900936
references.citation: Br J Dermatol. 1966 Jan;78(1):24-8
references.pmid: 5944482
references.citation: Int J Med Sci. 2009 Jun 05;6(4):168-76
references.pmid: 19521548
references.citation: Biochim Biophys Acta. 2007 Aug;1770(8):1181-6
references.pmid: 17524560
references.citation: J Immunol. 1977 May;118(5):1569-73
references.pmid: 140191
references.citation: J Rheumatol. 1994 Jul;21(7):1268-76
references.pmid: 7525957
references.citation: Circ Res. 2004 Jul 9;95(1):109-16
references.pmid: 15178641
references.citation: Trends Cardiovasc Med. 2009 Jan;19(1):26-30
references.pmid: 19467451
references.citation: Drugs. 2001;61(3):419-27
references.pmid: 11293650
references.citation: Clin Exp Rheumatol. 2007 Jan-Feb;25(1):60-6
references.pmid: 17417992
references.citation: Arthritis Rheum. 2004 Dec;50(12):3994-4001
references.pmid: 15593189
references.citation: Am J Transplant. 2004 Dec;4(12):2027-31
references.pmid: 15575905
references.citation: Ann Rheum Dis. 1996 Feb;55(2):122-7
references.pmid: 8712862
references.citation: J Rheumatol. 2009 Mar;36(3):576-82
references.pmid: 19228661
references.citation: Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2490-6
references.pmid: 16931790
references.citation: J Rheumatol. 2006 Sep;33(9):1918-9
references.pmid: 16960964
references.citation: Thromb Res. 2008;122(4):501-6
references.pmid: 18355897
references.citation: Rheumatology (Oxford). 2010 Dec;49(12):2290-7
references.pmid: 20823096
references.citation: Eur Respir J. 2007 Jul;30(1):1-2
references.pmid: 17601966
references.citation: Arthritis Rheum. 2000 Nov;43(11):2437-44
references.pmid: 11083266
references.citation: Cell Signal. 2009 Dec;21(12):1874-84
references.pmid: 19709640
references.citation: Arthritis Rheum. 1986 Apr;29(4):515-24
references.pmid: 3707629
references.citation: Curr Opin Rheumatol. 2009 Nov;21(6):617-22
references.pmid: 19633559
references.citation: Circulation. 2009 Jun 9;119(22):2894-903
references.pmid: 19470885
references.citation: J Am Coll Cardiol. 2006 May 16;47(10):2049-56
references.pmid: 16697324
references.citation: Curr Rheumatol Rep. 2004 Apr;6(2):141-8
references.pmid: 15016345
references.citation: PLoS One. 2009 Jun 17;4(6):e5903
references.pmid: 19536281
references.citation: Semin Arthritis Rheum. 1975 May;4(4):351-68
references.pmid: 1135634
references.citation: Ann Intern Med. 2004 Jan 6;140(1):37-50
references.pmid: 14706971
references.citation: J Biochem. 1994 Oct;116(4):794-800
references.pmid: 7883753
references.citation: J Immunol. 2007 May 1;178(9):5425-8
references.pmid: 17442922
references.citation: J Immunol. 1999 Oct 1;163(7):3969-75
references.pmid: 10490999
references.citation: N Engl J Med. 2009 May 7;360(19):1989-2003
references.pmid: 19420368
references.citation: Ann Rheum Dis. 2008 Aug;67(8):1121-6
references.pmid: 18029384
references.citation: Am J Respir Crit Care Med. 2008 Jul 1;178(1):81-8
references.pmid: 18420966
references.citation: J Mol Cell Cardiol. 2003 Jan;35(1):71-80
references.pmid: 12623301
references.citation: Ann Intern Med. 1967 Feb;66(2):323-34
references.pmid: 4224922
references.citation: Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11375-80
references.pmid: 12177436
references.citation: Curr Vasc Pharmacol. 2009 Jan;7(1):34-9
references.pmid: 19149638
references.citation: Arthritis Res Ther. 2006;8(4):R136
references.pmid: 16879746
references.citation: Circulation. 2004 Apr 6;109(13):1653-9
references.pmid: 15023873
references.citation: J Rheumatol. 1999 Nov;26(11):2389-94
references.pmid: 10555898
references.citation: Int Rev Immunol. 1995;12(2-4):247-58
references.pmid: 7650423
references.citation: J Dermatol Sci. 2010 Sep;59(3):153-62
references.pmid: 20663647
references.citation: Clin Exp Immunol. 2010 Sep;161(3):426-35
references.pmid: 20529088
references.citation: PLoS One. 2008 Jan 16;3(1):e1452
references.pmid: 18197262
references.citation: J Am Acad Dermatol. 1980 Feb;2(2):161-70
references.pmid: 7364973
references.citation: Clin Rheumatol. 2009 Dec;28(12):1379-84
references.pmid: 19690939
references.citation: J Cell Biol. 1998 Aug 10;142(3):873-81
references.pmid: 9700173
references.citation: Clin Exp Rheumatol. 1984 Apr-Jun;2(2):119-23
references.pmid: 6532617
references.citation: Presse Med. 2006 Apr;35(4 Pt 1):587-92
references.pmid: 16614599
references.citation: Br J Rheumatol. 1995 Jul;34(7):636-41
references.pmid: 7670782
references.citation: Discov Med. 2010 Aug;10(51):161-7
references.pmid: 20807477
references.citation: Arthritis Rheum. 2004 May;50(5):1578-85
references.pmid: 15146428
references.citation: Arterioscler Thromb Vasc Biol. 2002 Feb 1;22(2):243-8
references.pmid: 11834523
references.citation: Eur Respir J. 2006 Dec;28(6):1195-203
references.pmid: 16899485
references.citation: Nat Med. 2008 Jan;14(1):45-54
references.pmid: 18066075
references.citation: J Clin Invest. 1996 Aug 1;98(3):785-92
references.pmid: 8698871
references.citation: Br J Dermatol. 1990 Dec;123(6):725-34
references.pmid: 2176091
references.citation: Rheumatology (Oxford). 2005 Apr;44(4):488-94
references.pmid: 15695304
references.citation: Cochrane Database Syst Rev. 2000;(2):CD000956
references.pmid: 10796398
references.citation: J Pathol. 1992 Mar;166(3):255-63
references.pmid: 1517881
references.citation: J Clin Invest. 1974 Oct;54(4):880-9
references.pmid: 4430718
references.citation: Mod Rheumatol. 2009;19(5):530-5
references.pmid: 19590932
references.citation: N Engl J Med. 2002 Aug 1;347(5):322-9
references.pmid: 12151469
references.citation: J Rheumatol. 2000 Jan;27(1):149-54
references.pmid: 10648031
references.citation: Curr Opin Rheumatol. 2007 Nov;19(6):574-9
references.pmid: 17917538
references.citation: J Biol Chem. 2003 Jan 24;278(4):2750-7
references.pmid: 12429738
references.citation: Curr Opin Rheumatol. 2005 Nov;17(6):752-60
references.pmid: 16224254
references.citation: Am J Respir Crit Care Med. 2004 Feb 15;169(4):441-7
references.pmid: 14630619
references.citation: Ann Intern Med. 2000 Mar 21;132(6):425-34
references.pmid: 10733441
references.citation: Arthritis Rheum. 2008 Jun;58(6):1810-22
references.pmid: 18512816
references.citation: J Dermatol. 2007 Nov;34(11):769-72
references.pmid: 17973818
references.citation: Curr Rheumatol Rep. 2002 Apr;4(2):136-42
references.pmid: 11890879
references.citation: Br J Rheumatol. 1988 Aug;27(4):281-5
references.pmid: 3136816
references.citation: J Am Acad Dermatol. 2008 Oct;59(4):633-53
references.pmid: 18656283
references.citation: Springer Semin Immunopathol. 1999;21(4):397-414
references.pmid: 10945033
references.citation: Arch Dermatol. 1976 Nov;112(11):1553-7
references.pmid: 984860
references.citation: Nat Med. 2003 Jun;9(6):685-93
references.pmid: 12778167
references.citation: Autoimmun Rev. 2006 Feb;5(2):125-8
references.pmid: 16431342
references.citation: Arthritis Rheum. 2008 Sep;58(9):2854-65
references.pmid: 18759267
references.citation: Ann Rheum Dis. 2011 Jan;70(1):32-8
references.pmid: 20805294
references.citation: Am J Med. 1969 Mar;46(3):428-40
references.pmid: 5780367
references.citation: Arthritis Rheum. 1999 May;42(5):930-41
references.pmid: 10323448
references.citation: Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v10-1
references.pmid: 18784126