title: Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine.
abstract: Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and anti-inflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine.
authors.affiliation: Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala s/n, CP 11340, Mexico City, DF, México.
authors.forename: María Antonieta
authors.initials: MA
authors.lastname: Suárez-Souto
authors.forename: Eleazar
authors.initials: E
authors.lastname: Lara-Padilla
authors.forename: Humberto
authors.initials: H
authors.lastname: Reyna-Garfias
authors.forename: María
authors.initials: M
authors.lastname: Viloria
authors.forename: Pedro
authors.initials: P
authors.lastname: López-Sánchez
authors.forename: Víctor
authors.initials: V
authors.lastname: Rivera-Aguilar
authors.forename: Ángel
authors.initials: Á
authors.lastname: Miliar-García
authors.forename: Alexander
authors.initials: A
authors.lastname: Kormanovski
authors.forename: María Lilia
authors.initials: ML
authors.lastname: Domínguez-López
authors.forename: Rafael
authors.initials: R
authors.lastname: Campos-Rodríguez
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004386:Duodenum / Q000201:enzymology / Q000276:immunology*; D020869:Gene Expression Profiling; D007082:Ileum / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism; D007113:Immunity, Innate; D007144:Immunoglobulin J-Chains / Q000235:genetics / Q000378:metabolism; D007137:Immunoglobulin alpha-Chains / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000235:genetics / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood; D054467:Phospholipases A2 / Q000235:genetics / Q000378:metabolism; D011961:Receptors, Fc / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D016207:Cytokines; C045281:IgA receptor; D007144:Immunoglobulin J-Chains; D007137:Immunoglobulin alpha-Chains; D011961:Receptors, Fc; D054467:Phospholipases A2; D009113:Muramidase; D003345:Corticosterone; D009638:Norepinephrine
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