title: Three-dimensional impedance map analysis of rabbit liver.
abstract: Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5  ±  1.3 and 7.0  ±  0.3 μm for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA. pawlick2@illinois.edu
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Pawlicki
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Dapore
authors.forename: Sandhya
authors.initials: S
authors.lastname: Sarwate
authors.forename: William D
authors.initials: WD
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D011817:Rabbits; D012542:Scattering, Radiation; D013194:Staining and Labeling; D014465:Ultrasonics; D014463:Ultrasonography
references.citation: J Acoust Soc Am. 1978 Aug;64(2):423-57
references.pmid: 361793
references.citation: J Biol Chem. 1957 May;226(1):497-509
references.pmid: 13428781
references.citation: J Ultrasound Med. 2006 Aug;25(8):1031-40
references.pmid: 16870896
references.citation: J Acoust Soc Am. 1990 Jan;87(1):179-92
references.pmid: 2299033
references.citation: IEEE Trans Image Process. 1998;7(1):27-41
references.pmid: 18267377
references.citation: IEEE Trans Med Imaging. 2011 Jun;30(6):1206-13
references.pmid: 21278015
references.citation: J Acoust Soc Am. 2008 Feb;123(2):1195-1208
references.pmid: 18247919
references.citation: J Acoust Soc Am. 2005 Jan;117(1):413-23
references.pmid: 15704434
references.citation: J Acoust Soc Am. 1980 Jul;68(1):93-108
references.pmid: 11683186