title: Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis.
abstract: Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Yu
authors.forename: Saleh M
authors.initials: SM
authors.lastname: Ibrahim
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics* / Q000276:immunology*; D001327:Autoimmune Diseases / Q000235:genetics*; D001426:Bacterial Proteins / Q000008:administration & dosage* / Q000235:genetics*; D018834:Chaperonin 60 / Q000008:administration & dosage* / Q000235:genetics*; D007108:Immune Tolerance / Q000235:genetics*; D008297:Male; D059467:Transcriptome / Q000276:immunology*
chemical_list: D001426:Bacterial Proteins; D018834:Chaperonin 60; C074119:heat-shock protein 65, Mycobacterium
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