title: Double-masked randomized clinical trial evaluating the effect of a triclosan/copolymer dentifrice on periodontal healing after one-stage full-mouth debridement.
abstract: BACKGROUND
  This study evaluates the effect of triclosan/copolymer dentifrice on the 6-month clinical response of patients with generalized severe chronic periodontitis (GSCP) treated with one-stage, full-mouth ultrasonic debridement (FMUD).
  
  
  METHODS
  Thirty patients diagnosed with GSCP (≥8 teeth presenting probing depth [PD] ≥5 mm and bleeding on probing [BOP]) were selected and randomly allocated to a control group (n = 15) subjected to FMUD and daily use of a placebo dentifrice or to a test group (n = 15) subjected to FMUD and daily use of a triclosan/copolymer dentifrice. Patients were analyzed for the following parameters: full-mouth plaque index (FMPI), full-mouth BOP score (FMBS), gingival recession, PD, and clinical attachment level (CAL). Patients were evaluated at 3 and 6 months by a calibrated and masked examiner.
  
  
  RESULTS
  Initially, the groups presented similar periodontal conditions, with no significant differences in any of the parameters evaluated (P >0.05). In both groups, improvements in all periodontal parameters (P <0.05) were seen at the completion of the experimental period. Additionally, the test group showed lower FMPI (3 months) and FMBS (3 and 6 months) than the control group (P <0.05). Moreover, the CAL gain was significantly greater in the test group, especially at initially deep pockets (PD ≤7 mm). Whereas in the control group the CAL gain in deep pockets was 2.7 ± 0.6 mm, in the test group the CAL gain was 3.6 ± 1.4 mm (P <0.05).
  
  
  CONCLUSIONS
  Within the limits of the present study, the use of triclosan/copolymer dentifrice promoted additional clinical benefits in the treatment of GSCP treated by one-stage FMUD.
authors.affiliation: Department of Periodontics, Paulista University, São Paulo, São Paulo, Brazil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Pera
authors.forename: Paulo
authors.initials: P
authors.lastname: Ueda
authors.forename: Renato Corrêa Viana
authors.initials: RC
authors.lastname: Casarin
authors.forename: Fernanda Vieira
authors.initials: FV
authors.lastname: Ribeiro
authors.forename: Suzana Peres
authors.initials: SP
authors.lastname: Pimentel
authors.forename: Márcio Zaffalon
authors.initials: MZ
authors.lastname: Casati
authors.forename: Fabiano Ribeiro
authors.initials: FR
authors.lastname: Cirano
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000628:therapy*; D003773:Dental Plaque / Q000628:therapy; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000628:therapy; D005889:Gingival Recession / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000628:therapy; D057747:Periodontal Debridement / Q000295:instrumentation / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010919:Placebos; D011108:Polymers; D012969:Sodium Fluoride / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use*; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; D011108:Polymers; D014260:Triclosan; D012969:Sodium Fluoride