title: Biomimetic tissues on a chip for drug discovery.
abstract: Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.
authors.affiliation: Division of Immunology, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Ghaemmaghami
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hancock
authors.forename: Helen
authors.initials: H
authors.lastname: Harrington
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kaji
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D040761:Biomimetic Materials / Q000378:metabolism; D032701:Biomimetics / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D046210:Microfluidic Analytical Techniques; D055616:Microtechnology / Q000379:methods; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials
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