title: Acellular dermis-assisted prosthetic breast reconstruction:  a systematic and critical review of efficacy and associated morbidity.
abstract: BACKGROUND
  The use of acellular dermal matrix to assist in two-stage expander/implant breast reconstruction has increased over recent years. However, there are questions regarding the potential for increased morbidity when using these techniques relative to standard submuscular coverage techniques. This systematic review combines published data comparing the techniques, to compare morbidity and advantages of acellular dermal matrix relative to standard submuscular coverage techniques.
  
  
  METHODS
  An English language literature search was performed to find articles reporting outcomes of two-stage expander/implant reconstruction using acellular dermal matrix. The outcome categories analyzed were patient/treatment demographics, tissue expander characteristics, and complications.
  
  
  RESULTS
  Nine articles met inclusion criteria for this analysis. Six of these were matched cohort studies comparing outcomes of acellular dermal matrix techniques to standard submuscular techniques. The remaining three were case series of acellular dermal matrix techniques. The only difference found in complications was a higher rate of seroma for the acellular dermal matrix group (4.3 percent versus 8.4 percent, p = 0.03). Despite this, both groups illustrated similar rates of infection leading to explantation (3.2 percent for submuscular and 3.4 percent for acellular dermal matrix, p = 0.18). In addition, acellular dermal matrix techniques illustrated greater intraoperative fill volumes and consistently fewer fills required to reach expander capacity.
  
  
  CONCLUSIONS
  The use of acellular dermal matrix in two-stage expander/implant reconstruction offers a safety profile similar to that of standard submuscular techniques. Both techniques have shown similar rates of infection ultimately requiring explantation. In addition, acellular dermal matrix offers the advantage of a more rapid reconstruction with less need for manipulation of the prosthetic through filling.
  
  
  METHODS
  Therapeutic, III.
authors.affiliation: Philadelphia, Pa. From the University of Pennsylvania.
authors.forename: Hani
authors.initials: H
authors.lastname: Sbitany
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Serletti
mesh_terms: D001672:Biocompatible Materials; D018427:Breast Implants; D015331:Cohort Studies; D003094:Collagen; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology* / Q000601:surgery; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000601:surgery; D012086:Reoperation; D049291:Seroma / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology / Q000601:surgery; D015625:Tissue Expansion Devices
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen