title: Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi.
abstract: Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
authors.affiliation: These authors contributed equally to the work..
authors.forename: Chi-Jen
authors.initials: CJ
authors.lastname: Tai
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Ming-Shyan
authors.initials: MS
authors.lastname: Huang
authors.affiliation: These authors contributed equally to the work..
authors.forename: Zhi-Hong
authors.identifier: 0000-0003-4411-044X
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.affiliation: These authors contributed equally to the work..|Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy
chemical_list: C577609:2-(ethylthio)ethyl 6-(furan-2-yl)-3-methyl-4-oxo-4,5,6,7,tetrahydro-1H-indole-2-carboxylate; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D003603:Cytotoxins; D004224:Diterpenes; D005663:Furans; D007211:Indoles; C577614:krempfielin B; C577615:krempfielin C
references.citation: J Nat Prod. 2002 Oct;65(10):1475-8
references.pmid: 12398546
references.citation: Eur J Pharmacol. 2008 Jan 14;578(2-3):323-31
references.pmid: 17916350
references.citation: J Nat Prod. 2010 Nov 29;73(11):1785-91
references.pmid: 20979397
references.citation: J Nat Prod. 2005 Jul;68(7):1051-5
references.pmid: 16038547
references.citation: Org Biomol Chem. 2011 Feb 7;9(3):834-44
references.pmid: 21109855
references.citation: J Asian Nat Prod Res. 2006 Jun;8(4):287-91
references.pmid: 16864437
references.citation: Br J Pharmacol. 2009 Oct;158(3):713-25
references.pmid: 19663884
references.citation: Cancer Res. 1988 Feb 1;48(3):589-601
references.pmid: 3335022
references.citation: Mar Drugs. 2011;9(6):934-43
references.pmid: 21747739
references.citation: Cancer Res. 1988 Sep 1;48(17):4827-33
references.pmid: 3409223
references.citation: J Nat Prod. 1994 Sep;57(9):1212-9
references.pmid: 7798956
references.citation: Org Biomol Chem. 2010 May 21;8(10):2363-6
references.pmid: 20448893
references.citation: J Nat Prod. 2009 Jun;72(6):994-1000
references.pmid: 19391605
references.citation: J Nat Prod. 1994 May;57(5):574-80
references.pmid: 7914912