title: Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
abstract: Subspecies of the African trypanosome, Trypanosoma brucei, which cause human African trypanosomiasis, are transmitted by the tsetse fly, with transmission-essential lifecycle stages occurring in both the insect vector and human host. During infection of the human host, the parasite is limited to using glycolysis of host sugar for ATP production. This dependence on glucose breakdown presents a series of targets for potential therapeutic development, many of which have been explored and validated as therapeutic targets experimentally. These include enzymes directly involved in glucose metabolism (e.g., the trypanosome hexokinases), as well as cellular components required for development and maintenance of the essential subcellular compartments that house the major part of the pathway, the glycosomes.
authors.affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
authors.forename: April F
authors.initials: AF
authors.lastname: Coley
authors.forename: Heidi C
authors.initials: HC
authors.lastname: Dodson
authors.forename: Meredith T
authors.initials: MT
authors.lastname: Morris
authors.forename: James C
authors.initials: JC
authors.lastname: Morris
references.citation: J Cell Biol. 2006 May 22;173(4):521-32
references.pmid: 16717127
references.citation: J Cell Biol. 2002 Feb 18;156(4):643-51
references.pmid: 11839773
references.citation: Mol Biochem Parasitol. 2008 Mar;158(1):72-81
references.pmid: 18178267
references.citation: Plant J. 2009 Jan;57(1):146-59
references.pmid: 18785999
references.citation: Bioorg Med Chem. 1995 Nov;3(11):1423-7
references.pmid: 8634823
references.citation: EMBO J. 2002 Sep 2;21(17):4429-38
references.pmid: 12198145
references.citation: PLoS Negl Trop Dis. 2010 Apr 13;4(4):e659
references.pmid: 20405000
references.citation: Mol Biochem Parasitol. 2010 Jan;169(1):50-4
references.pmid: 19748525
references.citation: Exp Parasitol. 1997 Jan;85(1):16-23
references.pmid: 9024198
references.citation: Traffic. 2010 Feb;11(2):175-84
references.pmid: 20015113
references.citation: Mol Biochem Parasitol. 2008 Apr;158(2):202-7
references.pmid: 18262292
references.citation: J Biol Chem. 1994 Feb 25;269(8):6001-10
references.pmid: 8119946
references.citation: J Biol Chem. 1997 Feb 7;272(6):3207-15
references.pmid: 9013556
references.citation: J Biol Chem. 2006 May 5;281(18):12817-23
references.pmid: 16520372
references.citation: Drug Resist Updat. 2001 Feb;4(1):50-65
references.pmid: 11512153
references.citation: J Cell Sci. 2006 Jul 15;119(Pt 14):2968-74
references.pmid: 16787942
references.citation: Plant Cell. 2007 Jan;19(1):333-50
references.pmid: 17220199
references.citation: Biochem J. 2001 Jul 1;357(Pt 1):117-25
references.pmid: 11415442
references.citation: EMBO J. 1994 Oct 17;13(20):4908-18
references.pmid: 7957058
references.citation: J Cell Biol. 1995 Apr;129(2):345-55
references.pmid: 7721939
references.citation: Mol Biol Cell. 2003 Oct;14(10):4316-28
references.pmid: 14517338
references.citation: Exp Cell Res. 2007 May 1;313(8):1675-86
references.pmid: 17408615
references.citation: Nat Struct Biol. 2000 Dec;7(12):1091-5
references.pmid: 11101887
references.citation: Autophagy. 2006 Apr-Jun;2(2):107-18
references.pmid: 16874069
references.citation: J Biol Chem. 2008 May 30;283(22):14963-70
references.pmid: 18387941
references.citation: Exp Mol Pathol. 1983 Jun;38(3):322-35
references.pmid: 6852206
references.citation: J Cell Biol. 1999 Jan 25;144(2):255-66
references.pmid: 9922452
references.citation: J Biol Chem. 2005 Mar 11;280(10):9030-6
references.pmid: 15637070
references.citation: J Med Chem. 2006 Jan 12;49(1):215-23
references.pmid: 16392806
references.citation: Eukaryot Cell. 2006 Dec;5(12):2014-23
references.pmid: 17028241
references.citation: Mol Biochem Parasitol. 2005 Jul;142(1):47-55
references.pmid: 15907560
references.citation: J Med Chem. 2000 Nov 2;43(22):4135-50
references.pmid: 11063610
references.citation: J Cell Biol. 1995 Feb;128(4):509-23
references.pmid: 7860627
references.citation: Biochim Biophys Acta. 2007 Apr;1773(4):521-35
references.pmid: 17320990
references.citation: Mol Biochem Parasitol. 2010 May;171(1):45-9
references.pmid: 20138091
references.citation: Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):159-73
references.pmid: 8920004
references.citation: Eukaryot Cell. 2006 Sep;5(9):1539-49
references.pmid: 16963636
references.citation: Ann N Y Acad Sci. 1988;551:358-60
references.pmid: 3245672
references.citation: Annu Rev Microbiol. 1987;41:127-51
references.pmid: 3120638
references.citation: FEBS J. 2010 Aug;277(16):3279-88
references.pmid: 20629743
references.citation: Semin Oncol. 1991 Apr;18(2 Suppl 4):11-7
references.pmid: 2031191
references.citation: FEBS Lett. 1977 Aug 15;80(2):360-4
references.pmid: 142663
references.citation: J Cell Sci. 2006 Oct 1;119(Pt 19):3994-4001
references.pmid: 16968746
references.citation: Mol Biol Cell. 2010 Jun 15;21(12):2057-65
references.pmid: 20427571
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17718-23
references.pmid: 19008351
references.citation: J Mol Biol. 2000 Jul 21;300(4):697-707
references.pmid: 10891264
references.citation: J Cell Sci. 2008 May 15;121(Pt 10):1633-40
references.pmid: 18445678
references.citation: J Cell Biol. 1998 Apr 20;141(2):373-83
references.pmid: 9548716
references.citation: Parasit Vectors. 2008 Feb 12;1(1):3
references.pmid: 18275594
references.citation: Bioorg Med Chem Lett. 2006 Jul 1;16(13):3440-3
references.pmid: 16632348
references.citation: Mol Biochem Parasitol. 1990 Sep-Oct;42(2):293-6
references.pmid: 2270112
references.citation: EMBO J. 1988 Apr;7(4):1167-73
references.pmid: 3402435
references.citation: Biochem Biophys Res Commun. 1998 Nov 18;252(2):529-33
references.pmid: 9826565
references.citation: J Biol Chem. 2004 Mar 12;279(11):10692-701
references.pmid: 14670954
references.citation: J Bacteriol. 1997 Aug;179(15):4699-705
references.pmid: 9244255
references.citation: Biochim Biophys Acta. 1977 May 11;460(2):364-73
references.pmid: 15595
references.citation: J Cell Biol. 1996 Oct;135(1):123-37
references.pmid: 8858168
references.citation: Autophagy. 2008 Apr;4(3):294-308
references.pmid: 18365344
references.citation: EMBO J. 1996 Jun 17;15(12):2901-13
references.pmid: 8670791
references.citation: Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2087-92
references.pmid: 10681445
references.citation: Mol Microbiol. 2001 Mar;39(6):1443-51
references.pmid: 11260462
references.citation: Antimicrob Agents Chemother. 2004 Mar;48(3):924-9
references.pmid: 14982785
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8
references.pmid: 10200252
references.citation: Chem Biol. 2002 Jul;9(7):839-47
references.pmid: 12144928
references.citation: Proteomics. 2006 Jun;6(11):3275-93
references.pmid: 16622829
references.citation: Mol Biol Cell. 2005 Nov;16(11):5077-86
references.pmid: 16107562
references.citation: J Cell Biol. 2008 Apr 21;181(2):281-92
references.pmid: 18426976
references.citation: EMBO J. 1998 Jul 1;17(13):3542-55
references.pmid: 9649425
references.citation: J Biol Chem. 2005 Aug 5;280(31):28306-15
references.pmid: 15955817
references.citation: Mol Biochem Parasitol. 2010 Mar;170(1):41-4
references.pmid: 19925831
references.citation: Hum Mol Genet. 1998 Aug;7(8):1195-205
references.pmid: 9668159
references.citation: Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14177-82
references.pmid: 12386344
references.citation: Mol Biochem Parasitol. 2001 Jun;115(1):19-28
references.pmid: 11377736
references.citation: J Biol Chem. 2010 Feb 26;285(9):6670-80
references.pmid: 20028986
references.citation: J Biol Chem. 2003 Nov 21;278(47):46596-600
references.pmid: 12972414
references.citation: J Cell Biol. 1989 May;108(5):1657-64
references.pmid: 2654139
references.citation: J Cell Biol. 1995 Apr;129(1):65-80
references.pmid: 7535304
references.citation: Exp Parasitol. 2011 Feb;127(2):423-8
references.pmid: 20971104
references.citation: J Biol Chem. 1994 Mar 11;269(10):7558-63
references.pmid: 8125978
references.citation: J Biol Chem. 2007 Apr 27;282(17):12377-87
references.pmid: 17329254
references.citation: J Mol Biol. 2008 Sep 12;381(4):867-80
references.pmid: 18598704
references.citation: Cell. 2005 Jul 15;122(1):85-95
references.pmid: 16009135
references.citation: Prog Drug Res. 2007;64:171, 173-89
references.pmid: 17195475
references.citation: Eukaryot Cell. 2007 Aug;6(8):1439-49
references.pmid: 17586720
references.citation: Mol Cell Biol. 1998 Jan;18(1):388-99
references.pmid: 9418886