title: Successful treatment of severe asthma-associated plastic bronchitis with extracorporeal membrane oxygenation.
abstract: We describe a case of near-fatal asthma requiring extracorporeal membrane oxygenation (ECMO). The patient presented with severe respiratory distress, which was not responsive to conventional pharmacological therapy. The patient also failed to respond to mechanical ventilation and thus was placed on venovenous ECMO for temporary pulmonary support. A fiberoptic bronchoscopy revealed that large amounts of thick bronchial secretions had occluded the main bronchus, which suggested plastic bronchitis secondary to asthma. Aggressive airway hygiene with frequent bronchoscopies and application of biphasic cuirass ventilation for facilitation of secretion clearance were performed to improve the patient's respiratory status. The patient achieved a full recovery and suffered no neurological sequelae. This case illustrates that aggressive pulmonary hygiene with ECMO is a useful therapy for patients with asthma-associated plastic bronchitis.
authors.affiliation: Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Momoka
authors.initials: M
authors.lastname: Tonan
authors.forename: Soshi
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Akio
authors.initials: A
authors.lastname: Kimura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Matsuyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kinose
authors.forename: Maiko
authors.initials: M
authors.lastname: Sawada
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shime
authors.forename: Natsuko
authors.initials: N
authors.lastname: Tokuhira
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kato
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Higaki
authors.forename: Tadaki
authors.initials: T
authors.lastname: Oomae
authors.forename: Satoru
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D001249:Asthma / Q000150:complications / Q000628:therapy*; D001991:Bronchitis / Q000150:complications / Q000628:therapy*; D002648:Child; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans
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