title: Electrochemical sensor based on molecularly imprinted film at polypyrrole-sulfonated graphene/hyaluronic acid-multiwalled carbon nanotubes modified electrode for determination of tryptamine.
abstract: An imprinted electrochemical sensor based on polypyrrole-sulfonated graphene (PPy-SG)/hyaluronic acid-multiwalled carbon nanotubes (HA-MWCNTs) for sensitive detection of tryptamine was presented. Molecularly imprinted polymers (MIPs) were synthesized by electropolymerization using tryptamine as the template, and para-aminobenzoic acid (pABA) as the monomer. The surface feature of the modified electrode was characterized by cyclic voltammetry (CV). The proposed sensor was tested by chronoamperometry. Several important parameters controlling the performance of the molecularly imprinted sensor were investigated and optimized. The results showed that the PPy-SG composites films showed improved conductivity and electrochemical performances. HA-MWCNTs bionanocomposites could enhance the current response evidently. The good selectivity of the sensor allowed three discriminations of tryptamine from interferents, which include tyramine, dopamine and tryptophan. Under the optimal conditions, a linear ranging from 9.0×10(-8) mol L(-1) to 7.0×10(-5) mol L(-1) for the detection of tryptamine was observed with the detection limit of 7.4×10(-8) mol L(-1) (S/N=3). This imprinted electrochemical sensor was successfully employed to detect tryptamine in real samples.
authors.affiliation: College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: Xianrong
authors.initials: X
authors.lastname: Xing
authors.forename: Su
authors.initials: S
authors.lastname: Liu
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yu
authors.forename: Wenjing
authors.initials: W
authors.lastname: Lian
authors.forename: Jiadong
authors.initials: J
authors.lastname: Huang
mesh_terms: D000476:Alkanesulfonates / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D054802:Molecular Imprinting / Q000379:methods; D036103:Nanotechnology / Q000295:instrumentation; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013499:Surface Properties; D014363:Tryptamines / Q000032:analysis* / Q000737:chemistry
chemical_list: D000476:Alkanesulfonates; D008567:Membranes, Artificial; D037742:Nanotubes, Carbon; D011108:Polymers; D011758:Pyrroles; D014363:Tryptamines; C067635:polypyrrole; C030820:tryptamine; D006108:Graphite; D006820:Hyaluronic Acid