title: OGEE: an online gene essentiality database.
abstract: OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our understanding of the essentiality of genes. This is achieved by collecting not only experimentally tested essential and non-essential genes, but also associated gene features such as expression profiles, duplication status, conservation across species, evolutionary origins and involvement in embryonic development. We focus on large-scale experiments and complement our data with text-mining results. Genes are organized into data sets according to their sources. Genes with variable essentiality status across data sets are tagged as conditionally essential, highlighting the complex interplay between gene functions and environments. Linked tools allow the user to compare gene essentiality among different gene groups, or compare features of essential genes to non-essential genes, and visualize the results. OGEE is freely available at http://ogeedb.embl.de.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Pablo
authors.initials: P
authors.lastname: Minguez
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Lercher
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D015870:Gene Expression; D020131:Genes, Duplicate; D020043:Genes, Essential; D020407:Internet; D012984:Software
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