title: Effect of soy phytoestrogen on metabolic and hormonal disturbance of women with polycystic ovary syndrome.
abstract: BACKGROUND
  Phytoestrogens are a group of plants derived compounds with weekly estrogen effect that appear to have protective effects on metabolic and hormonal abnormalities of women with polycystic ovary syndrome (PCOS). So the aim of this study was to investigate the effect of soy phytoestrogens on reproductive hormones and lipid profiles in PCOS women.
  
  
  METHODS
  In this quasi-randomized trial, 146 subjects with PCOS were divided into two groups; the experimental group who received Genistein (Bergamon, Italy) 18 mg twice a day orally and the control group that received similar capsules with cellulose for 3 months. Hormonal features and lipid profiles were measured before and after 3 months of supplement therapy.
  
  
  RESULTS
  After 3 months of supplement therapy there were no statistically significant differences in high density lipoprotein cholesterol (HDL) and follicle stimulating hormone (FSH) serum levels in Genistein and placebo group before and after treatment; however serum levels of luteinizing hormone (LH), triglyceride (TG), low density lipoprotein cholesterol (LDL), dehydroepiandrostrone sulfate (DHEAS) and testosterone were significantly decreased after 3 months therapy in Genistein group.
  
  
  CONCLUSIONS
  Genistein consumption may prevent cardiovascular and metabolic disorders in PCOS patients by improving their reproductive hormonal and lipid profiles.
authors.affiliation: Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Khani
authors.forename: Ferdous
authors.initials: F
authors.lastname: Mehrabian
authors.forename: Elaheh
authors.initials: E
authors.lastname: Khalesi
authors.forename: Azadeh
authors.initials: A
authors.lastname: Eshraghi
references.citation: Fertil Steril. 2008 Nov;90(5):1826-33
references.pmid: 18166189
references.citation: J Nutr. 2004 Sep;134(9):2395-400
references.pmid: 15333734
references.citation: J Clin Endocrinol Metab. 2006 May;91(5):1714-22
references.pmid: 16492701
references.citation: Am J Clin Nutr. 2007 Apr;85(4):1148-56
references.pmid: 17413118
references.citation: Eur J Clin Nutr. 2003 Aug;57(8):940-6
references.pmid: 12879088
references.citation: J Res Med Sci. 2010 Nov;15(6):317-23
references.pmid: 21526104
references.citation: Am J Med. 2001 Dec 1;111(8):607-13
references.pmid: 11755503
references.citation: Life Sci. 2003 Dec 26;74(6):733-42
references.pmid: 14654166
references.citation: J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):37-45
references.pmid: 17588743
references.citation: Diabetes Res Clin Pract. 2003 Jul;61(1):29-37
references.pmid: 12849921
references.citation: Fertil Steril. 2005 May;83(5):1343-6
references.pmid: 15866567
references.citation: Am J Clin Nutr. 2000 Aug;72(2):395-400
references.pmid: 10919933
references.citation: Nutrition. 2006 Feb;22(2):104-13
references.pmid: 16459222
references.citation: Endokrynol Pol. 2011;62(3):238-42
references.pmid: 21717406
references.citation: Fertil Steril. 2004 Jan;81(1):19-25
references.pmid: 14711538
references.citation: Am J Clin Nutr. 2002 Dec;76(6):1191-201
references.pmid: 12450882
references.citation: N Engl J Med. 2005 Mar 24;352(12):1223-36
references.pmid: 15788499
references.citation: J Nutr. 2000 Mar;130(3):660S-1S
references.pmid: 10702604
references.citation: J Am Coll Cardiol. 2000 May;35(6):1403-10
references.pmid: 10807439
references.citation: Fertil Steril. 2005 May;83(5):1454-60
references.pmid: 15866584
references.citation: Can J Cardiol. 2006 Feb;22 Suppl B:85B-90B
references.pmid: 16498518
references.citation: Circulation. 2000 Nov 14;102(20):2555-9
references.pmid: 11076833
references.citation: Diabetes Care. 2002 Oct;25(10):1709-14
references.pmid: 12351466