title: Silanol as a removable directing group for the Pd(II)-catalyzed direct olefination of arenes.
abstract: Need some direction? Silanol was developed as a directing group for the Pd(II)-catalyzed oxidative Heck-type reaction of arenes. A one-pot C-H activation/desilylation process of benzyldiisopropylsilanol was also demonstrated, providing a powerful approach for the synthesis of ortho-alkenyl-substituted alkylarenes. Considering the easily attachable and readily removable properties of the silanol group, this reaction will find broad synthetic applications.
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford St. Indianapolis, IN 46202, USA.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.forename: Haibo
authors.initials: H
authors.lastname: Ge
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D012821:Silanes; C082343:silanol; D010165:Palladium