title: Acute liver failure secondary to khat (Catha edulis)-induced necrotic hepatitis requiring liver transplantation: case report.
abstract: We describe the case of a 26-year-old man with acute liver failure secondary to ingestion of khat (Catha edulis) leaves. In fact, this is the first case of acute liver failure due to khat reported outside the United Kingdom. The combination of specific epidemiologic data (young man of East African origin) and clinical features (central nervous system stimulation, withdrawal reactions, toxic autoimmune-like hepatitis) led to the diagnosis. Mechanisms of action and potential side effects of khat are elaborated on.
authors.affiliation: Hepatology Department, University Hospitals Leuven, Leuven, Belgium. philip.roelandt@uzleuven.be
authors.forename: P
authors.initials: P
authors.lastname: Roelandt
authors.forename: C
authors.initials: C
authors.lastname: George
authors.forename: F
authors.initials: F
authors.lastname: d'Heygere
authors.forename: R
authors.initials: R
authors.lastname: Aerts
authors.forename: D
authors.initials: D
authors.lastname: Monbaliu
authors.forename: W
authors.initials: W
authors.lastname: Laleman
authors.forename: D
authors.initials: D
authors.lastname: Cassiman
authors.forename: C
authors.initials: C
authors.lastname: Verslype
authors.forename: W
authors.initials: W
authors.lastname: van Steenbergen
authors.forename: J
authors.initials: J
authors.lastname: Pirenne
authors.forename: A
authors.initials: A
authors.lastname: Wilmer
authors.forename: F
authors.initials: F
authors.lastname: Nevens
mesh_terms: D000328:Adult; D001706:Biopsy; D029754:Catha / Q000009:adverse effects*; D006085:Graft Survival; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D009336:Necrosis; D010936:Plant Extracts / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts