title: Targeting airway smooth muscle in airways diseases: an old concept with new twists.
abstract: Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.
authors.affiliation: Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, PA 19104-3413, USA.
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Koziol-White
authors.forename: Gautam
authors.initials: G
authors.lastname: Damera
authors.forename: Reynold A
authors.initials: RA
authors.lastname: Panettieri
mesh_terms: D055011:Ablation Techniques; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D016084:Bronchoconstriction / Q000187:drug effects; D001993:Bronchodilator Agents / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology / Q000601:surgery; D009130:Muscle, Smooth / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology / Q000601:surgery; D019141:Respiratory System Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D019141:Respiratory System Agents
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