title: Three-dimensional in silico breast phantoms for multimodal image simulations.
abstract: Anatomic simulators have provided researchers with the realistic objects needed to develop and evaluate medical imaging approaches. Today we have new insights into the cellular biology of breast tissues that is driving many new targeted diagnostic and therapeutic approaches, including molecular imaging. We report on our initial efforts to build a scalable framework for the construction of realistic 3-D in silico breast phantoms (ISBP) capable of leveraging existing knowledge and yet adaptable to fully integrate future discoveries. The ISBP frames are developed with scalable anatomical shapes and morphologic features as adapted from a rich literature on this topic. Frames are populated with tissue subtypes essential for imaging and object contrast functions are assigned. These data can be resampled to match the intrinsics scales of various imaging modalities; we explore mammography, sonography and computed tomography. Initial comparisons between simulated and clinical images demonstrate reasonable agreement and provides guidance for future development of a more realistic ISBP. An end-to-end simulation of breast images is described to demonstrate techniques for including stochastic variability and deterministic physical principles on which image formation is based.
authors.affiliation: Department of Bioengineering, Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Mahr
authors.forename: Rohit
authors.initials: R
authors.lastname: Bhargava
authors.forename: Michael F
authors.initials: MF
authors.lastname: Insana
mesh_terms: D001940:Breast / Q000033:anatomy & histology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D008327:Mammography / Q000295:instrumentation* / Q000379:methods; D008953:Models, Anatomic; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods; D016217:Ultrasonography, Mammary / Q000295:instrumentation* / Q000379:methods
references.citation: Aesthetic Plast Surg. 2002 Sep-Oct;26(5):348-55
references.pmid: 12432473
references.citation: J Acoust Soc Am. 1997 Aug;102(2 Pt 1):1177-90
references.pmid: 9265762
references.citation: J Acoust Soc Am. 2005 Jan;117(1):413-23
references.pmid: 15704434
references.citation: J Acoust Soc Am. 2003 Feb;113(2):1166-76
references.pmid: 12597210
references.citation: Radiology. 2008 Mar;246(3):725-33
references.pmid: 18195383
references.citation: J Plast Reconstr Aesthet Surg. 2008;61(3):314-8
references.pmid: 18267311
references.citation: J Clin Pathol. 1996 Jan;49(1):48-52
references.pmid: 8666685
references.citation: Ultrasound Med Biol. 2006 Jun;32(6):857-74
references.pmid: 16785008
references.citation: J Clin Ultrasound. 1982 Feb;10(2):67-75
references.pmid: 6804504
references.citation: Phys Med Biol. 1996 May;41(5):909-23
references.pmid: 8735257
references.citation: Breast Cancer Res Treat. 2007 Dec;106(2):171-9
references.pmid: 17221150
references.citation: Cancer. 2001 Jun 15;91(12):2263-72
references.pmid: 11413514
references.citation: Med Phys. 2002 Sep;29(9):2131-9
references.pmid: 12349935
references.citation: Med Phys. 2009 Jul;36(7):3122-31
references.pmid: 19673211
references.citation: Breast Cancer Res. 2006;8(4):107
references.pmid: 16879731
references.citation: Phys Med Biol. 1990 Feb;35(2):235-47
references.pmid: 2315379
references.citation: Phys Med Biol. 2003 Nov 21;48(22):3699-719
references.pmid: 14680268
references.citation: J Midwifery Womens Health. 2007 Nov-Dec;52(6):556-63
references.pmid: 17983992
references.citation: Acad Radiol. 2003 Feb;10(2):198-204
references.pmid: 12583572
references.citation: J Anat. 2005 Jun;206(6):525-34
references.pmid: 15960763
references.citation: Plast Reconstr Surg. 1997 Aug;100(2):468-79
references.pmid: 9252618
references.citation: Cancer. 2004 Nov 1;101(9):1947-57
references.pmid: 15382093
references.citation: J Pathol. 2004 May;203(1):538-44
references.pmid: 15095476
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 1992;39(2):262-7
references.pmid: 18263145
references.citation: Phys Med Biol. 2006 Mar 7;51(5):1299-312
references.pmid: 16481695
references.citation: Int J Clin Oncol. 2005 Apr;10(2):112-6
references.pmid: 15864696
references.citation: Med Phys. 2003 Jul;30(7):1914-25
references.pmid: 12906210
references.citation: Breast Cancer Res Treat. 2006 Jun;97(3):285-91
references.pmid: 16791485