title: [Effect of total flavonoids from Chrysanthemun morifolium on learning and memory in aging mice].
abstract: OBJECTIVE
  To investigate the effect of total fiavonoids from Chrysanthemun morifolium (TFCM) on learning and memory, and cholinergic system function in aging mice.
  
  
  METHODS
  The aging mice model was established by subcutaneous injection of D-galactose. ICR mice were divided into five groups (n=10): contrA group, model group, and TFCM groups. Mice in TFCM groups were given TFCM (50,100 or 150 mg/kg) by gastric irrigation once a day. Learning and memory ability were evaluated by Morris water maze test. The MDA content, SOD and Ach E activity were also measured.
  
  
  RESULTS
  Compared with control group, learning and memory ability declined in the D-galactose-induced aging mice; meanwhile MDA content and AchE activity increased, SOD activity decreased. Treatment with TFCM (100, 150 mg/kg) ameliorated the decrease in learning and memory ability of aging mice. Compared with model group, TFCM (100, 150 mg/kg) could also decrease MDA content and Ach E activity, and increase SOD activity in aging mice.
  
  
  CONCLUSIONS
  TFCM may improve the learning and memory ability of aging mice. The mechanism is involved in its antioxidative characteristic and improvement of central cholinergic system function.
authors.affiliation: The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
authors.forename: Pian-hong
authors.initials: PH
authors.lastname: Zhang
authors.forename: Hu-qiang
authors.initials: HQ
authors.lastname: Tang
authors.forename: Ming-zhi
authors.initials: MZ
authors.lastname: Zheng
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Chen
authors.forename: Yue-liang
authors.initials: YL
authors.lastname: Shen
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D059329:Cholinergic Neurons / Q000502:physiology; D031202:Chrysanthemum / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D000975:Antioxidants; D005419:Flavonoids