title: (99m)TC-octreotide scintigraphy and somatostatin receptor subtype expression in juvenile nasopharyngeal angiofibromas.
abstract: BACKGROUND
  The main goal of the study was the analysis of somatostatin receptor (SSTR) expression on juvenile nasopharyngeal angiofibroma (JNA) cells and a subsequent analysis of the utility of SST analog-based scintigraphy in JNA diagnostics.
  
  
  METHODS
  Nine JNA cases were analyzed. All tissue samples were analyzed for the expression of SSTRs. In 2 cases, scintigraphy was performed after the intravenous (IV) administration of an SST analog. MRI of the craniofacial region was subsequently performed.
  
  
  RESULTS
  The SST analogues were accumulated in areas matching pathologic tissue in the nasopharynx. Immunohistochemical evaluation of the tissue samples proved the overexpression of SSTRs.
  
  
  CONCLUSIONS
  SSTRs are overexpressed on JNA cells. The SST analog (99m)TC-octreotide is effectively bound to JNA cells. SST analogues might be used in the diagnostics and treatment of primary, recurrent, or residual JNA.
authors.affiliation: Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, Warsaw, Poland. wkukwa@yahoo.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kukwa
authors.forename: Renata
authors.initials: R
authors.lastname: Andrysiak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kukwa
authors.forename: Alicja
authors.initials: A
authors.lastname: Hubalewska-Dydejczyk
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Gronkiewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Wojtowicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Krolicki
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wierzchowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grochowski
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018322:Angiofibroma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D015282:Octreotide / Q000031:analogs & derivatives; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000145:classification / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C415944:technetium Tc 99m-tricine-hydrazinonicotinyl-Phe(1)-Tyr(3)-octreotide; D015282:Octreotide