title: Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles.
abstract: This study investigated the accumulation of cadmium (0-8 mg Cd L⁻¹) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at ≥ 4 mg L⁻¹ Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue.
authors.affiliation: Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Shan
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Ye
authors.forename: Shuozeng
authors.initials: S
authors.lastname: Dou
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism*; D005432:Flounder / Q000033:anatomy & histology* / Q000254:growth & development / Q000378:metabolism*; D005880:Gills / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D018384:Oxidative Stress; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014874:Water Pollutants, Chemical; D002104:Cadmium; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione