title: [Two cases of juvenile-onset and adult-onset recurrent respiratory papillomatosis].
abstract: We recently experienced one each of 2 types of recurrent respiratory papillomatosis (RRP). Case 1 (juvenile-onset type): A 30-year-old woman presenting with bloody sputum and large tumors with cavities on her chest Xray film, was referred to our hospital. She had been diagnosed with laryngeal papillomatosis when she was three years old. According to our bronchoscopical examination biopsy, she was diagnosed with squamous cell carcinoma of the lung in addition to papillomatosis of the trachea and bronchus. Although chemotherapy was performed, she died 2 years after the diagnosis of lung cancer without any distinct treatment efficacy. Case 2 (adult-onset type): A 43 year-old woman presenting with fever and dry cough visited our hospital. Chest CT revealed that there was narrowing of bilateral main bronchi and hilar lymphadenopathy. Bronchoscopic examination revealed diffuse papilloma distributed extensively from the trachea to bilateral main bronchi. However, she recovered spontaneously in 6 months and has remained stable without recurrence. Both cases were diagnosed with RRP based on the separation of HPV in case 1 and pathological findings of koilocytosis in case 2. Case 1 was complicated with squamous cell carcinoma of the lung in the clinical course, presumably due to occurrence of malignant conversion of papillomatosis. Since RRP is a rare but refractory disease, novel effective treatment is necessary.
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Shiobara
authors.forename: Hideto
authors.initials: H
authors.lastname: Goto
authors.forename: Masako
authors.initials: M
authors.lastname: Hoshino
authors.forename: Toshinori
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Masaru
authors.initials: M
authors.lastname: Ito
authors.forename: Akinori
authors.initials: A
authors.lastname: Nozawa
authors.forename: Jun
authors.initials: J
authors.lastname: Tsukiji
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology