title: Potential of functional MRI as a biomarker in early Alzheimer's disease.
abstract: Functional magnetic resonance imaging (fMRI) is a relative newcomer in the field of biomarkers for Alzheimer's disease (AD). fMRI has several potential advantages, particularly for clinical trials, as it is a noninvasive imaging technique that does not require the injection of contrast agent or radiation exposure and thus can be repeated many times during a longitudinal study. fMRI has relatively high spatial and reasonable temporal resolution, and can be acquired in the same session as structural magnetic resonance imaging. Perhaps most importantly, fMRI may provide useful information about the functional integrity of brain networks supporting memory and other cognitive domains, including the neural correlates of specific behavioral events, such as successful versus failed memory formation.
authors.affiliation: Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. reisa@rics.bwh.harvard.edu
authors.forename: Reisa
authors.initials: R
authors.lastname: Sperling
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D015415:Biomarkers; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003071:Cognition; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008568:Memory; D012306:Risk
chemical_list: D015415:Biomarkers
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