title: ATRA Induced Reactive Hemophagocytosis: a Case Report.
abstract: All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of hemophagocytic syndrome. We report a case of APL showing differentiated cells being phagocytosed by marrow histiocytes while patient was getting ATRA therapy.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Monica
authors.initials: M
authors.lastname: Sharma
authors.forename: Jasmita
authors.initials: J
authors.lastname: Dass
authors.forename: Seema
authors.initials: S
authors.lastname: Tyagi
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