title: Value of percutaneous radiofrequency ablation with or without percutaneous vertebroplasty for pain relief and functional recovery in painful bone metastases.
abstract: OBJECTIVE
  To evaluate the effectiveness of percutaneous radiofrequency (RF) ablation with or without percutaneous vertebroplasty (PV) on pain relief, functional recovery and local recurrence at 6 months' follow-up (FU), in patients with painful osseous metastases.
  
  
  METHODS
  Thirty RF ablations were performed in 24 patients (mean age: 61 years) with bone metastases. Half of the patients had an additional PV. The primary end point was pain relief evaluated by a visual analogue scale (VAS) before treatment, and at 1 and 6 months' FU. Functional outcome was assessed according to the evolution of their ability to walk at 6 months' FU. Imaging FU was available in 20 out of 24 patients with a mean delay of 4.7 months.
  
  
  RESULTS
  Reduction of pain was obtained at 6 months FU in 81% of cases (15 out of 18). Mean pretreatment VAS was 6.4 (±2.7). Mean VAS was 1.9 (±2.4) at 1 month FU, and 2.3 (±2.9) at 6 months' FU. Pain was significantly reduced at 6 months FU (mean VAS reduction = 4.1; P < 0.00001). Functional improvement was obtained in 74% of the cases. Major complications rate was 12.5 % (3 out of 24) with 2 skin burns, and 1 case of myelopathy. Local tumour recurrence or progression was recorded in 5 cases.
  
  
  CONCLUSIONS
  Radiofrequency ablation is an effective technique in terms of pain relief and functional recovery for the treatment of bone metastases, which provides a relatively low rate of local recurrence.
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47, Boulevard de l'Hôpital, 75013, Paris, France. fredclare5@msn.com
authors.forename: Frédéric
authors.initials: F
authors.lastname: Clarençon
authors.forename: Betty
authors.initials: B
authors.lastname: Jean
authors.forename: Hang-Phuong
authors.initials: HP
authors.lastname: Pham
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cormier
authors.forename: Gilbert
authors.initials: G
authors.lastname: Bensimon
authors.forename: Michèle
authors.initials: M
authors.lastname: Rose
authors.forename: Philippe
authors.initials: P
authors.lastname: Maksud
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiras
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001859:Bone Neoplasms / Q000556:secondary* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D059408:Pain Management; D010147:Pain Measurement; D011183:Postoperative Complications; D020127:Recovery of Function; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000706:statistics & numerical data*
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