title: Self-reported mammography use following BRCA1/2 genetic testing may be overestimated.
abstract: Adherence to mammographic screening recommendations following BRCA1/2 testing is generally assessed through self-reports. However, the validity of self-reported mammography by women who had undergone BRCA1/2 genetic testing is still unknown. This study aimed to assess the validity of self-reported mammography use in the past 12 months among women who had undergone BRCA1/2 testing. Using a self-administered questionnaire, 307 women who never had cancer were asked 1 year following BRCA1/2 test result disclosure whether they undergone a mammography in the past 12 months. For each participant, this information was compared to that provided by the Quebec Health Insurance Board administrative data set for mammography claims during the same period, here considered as the gold standard. Sensitivity (Sn), specificity (Sp), predictive values, and Cohen's kappa (κ) were calculated. The robustness of these estimates was assessed using sensitivity analysis in which we varied the administrative data time lapses up to 18 months. Overall, the agreement between self-reports and administrative data was 88% (κ = 0.74). Among the 180 participants who had a mammography according to the administrative data, 172 adequately reported this information (Sn = 96%). Sp was moderate (76%), meaning that 24% of those who did not have a mammography reported one. Extending the time lapses to 18 months increased the Sp substantially (Sp = 90%). Self-report overestimates the use of mammography, mainly because women tend to minimize the elapsed time since their last mammography. Self-reports should be used cautiously to assess adherence to mammographic screening following BRCA1/2 testing.
authors.affiliation: Faculté de pharmacie, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Quebec, QC, G1V 0A6, Canada.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Larouche
authors.forename: Karine
authors.initials: K
authors.lastname: Bouchard
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Chiquette
authors.forename: Christine
authors.initials: C
authors.lastname: Desbiens
authors.forename: Jacques
authors.initials: J
authors.lastname: Simard
authors.forename: Michel
authors.initials: M
authors.lastname: Dorval
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics*; D055088:Early Detection of Cancer; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008327:Mammography / Q000706:statistics & numerical data*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015203:Reproducibility of Results; D057566:Self Report; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human
references.citation: J Natl Compr Canc Netw. 2006 Feb;4(2):156-76
references.pmid: 16451772
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2862-7
references.pmid: 16365001
references.citation: JAMA. 1997 Mar 26;277(12):997-1003
references.pmid: 9091675
references.citation: J Obstet Gynaecol Can. 2007 Jan;29(1):45-60
references.pmid: 17346477
references.citation: Psychosom Med. 1979 May;41(3):209-18
references.pmid: 472086
references.citation: J Genet Couns. 2008 Aug;17(4):314-26
references.pmid: 18481164
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):1989-95
references.pmid: 15598752
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1182-7
references.pmid: 14652278
references.citation: Am J Epidemiol. 2003 Feb 1;157(3):267-72
references.pmid: 12543627
references.citation: Eur J Hum Genet. 2011 May;19(5):494-9
references.pmid: 21248744
references.citation: J Clin Epidemiol. 2011 Dec;64(12):1434-43
references.pmid: 21764559
references.citation: Bull Cancer. 2004 Mar;91(3):219-37
references.pmid: 15171047
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):748-57
references.pmid: 18381468
references.citation: J Genet Couns. 2007 Jun;16(3):241-60
references.pmid: 17508274
references.citation: Cancer Causes Control. 2009 Feb;20(1):1-13
references.pmid: 18802779
references.citation: Prev Med. 2008 Jun;46(6):489-91
references.pmid: 18407343
references.citation: Am J Prev Med. 1999 Oct;17(3):211-29
references.pmid: 10987638
references.citation: J Med Genet. 2007 Feb;44(2):107-21
references.pmid: 16905680
references.citation: Behav Med. 2005 Fall;31(3):93-105
references.pmid: 16252621
references.citation: JAMA. 1996 Jun 26;275(24):1885-92
references.pmid: 8648868
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1699-705
references.pmid: 19505902
references.citation: Psychooncology. 2012 May;21(5):515-23
references.pmid: 21370312