title: Central auditory nervous system dysfunction in infants with non-syndromic cleft lip and/or palate.
abstract: OBJECTIVE
  Peripheral hearing loss has been commonly reported in children with non-syndromic cleft lip and/or palate (NSCLP) but few studies have provided information about central auditory nervous system (CANS) functioning for this group. The main objective of this study was to explore CANS functioning in infants with NSCLP through analysis of auditory evoked potentials (AEPs).
  
  
  METHODS
  AEPs including auditory brainstem response (ABR), middle latency response (MLR), and mismatch negativity (MMN) recordings were conducted in 34 infants of Chinese ethnicity with NSCLP and an equivalent number of normal controls.
  
  
  RESULTS
  There was no significant difference in ABR (all measurements, including wave I, III, V latencies, I-V inter-wave latency, and wave V amplitude), or MLR (recordable components, Na, Pa latencies, and Na-Pa amplitude) findings between the two groups. However, infants with NSCLP had a significantly smaller MMN response than their normal controls, using MMN strength as the measurement.
  
  
  CONCLUSIONS
  Significant abnormal auditory evoked potential findings at the cortical level suggest that infants with NSCLP may be at risk of central auditory discrimination dysfunction. Further effort is needed to determine auditory processing abilities in infants with NSCLP.
authors.affiliation: Center for Communication Disorders, The University of Hong Kong, Hong Kong, China. hkufrank@hotmail.com
authors.forename: Frank F
authors.initials: FF
authors.lastname: Yang
authors.forename: Bradley
authors.initials: B
authors.lastname: McPherson
authors.forename: Huang
authors.initials: H
authors.lastname: Shu
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D017677:Age Distribution; D001304:Auditory Diseases, Central / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D002681:China; D002971:Cleft Lip / Q000175:diagnosis / Q000453:epidemiology; D002972:Cleft Palate / Q000175:diagnosis / Q000453:epidemiology; D015331:Cohort Studies; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution