title: Concise survey of Staphylococcus aureus virulence factors that promote adhesion and damage to peri-implant tissues.
abstract: Staphylococcus aureus is the leading cause of infection in orthopedic implants and of osteomyelitis consequent to it. Here we focus on the wide array of virulence factors that endow S. aureus with its abilities to colonize peri-prosthesis tissues and to attack and damage them. Following an infective strategy orchestrated by agr locus, Staphylococcus aureus first deploys virulence factors for adhesion to the prosthesis and peri-prosthesis tissues and then launches its attack by delivering destructive factors.
authors.affiliation: Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy. carlarenata.arciola@ior.it
authors.forename: Carla Renata
authors.initials: CR
authors.lastname: Arciola
authors.forename: Livia
authors.initials: L
authors.lastname: Visai
authors.forename: Francesca
authors.initials: F
authors.lastname: Testoni
authors.forename: Susanna
authors.initials: S
authors.lastname: Arciola
authors.forename: Davide
authors.initials: D
authors.lastname: Campoccia
authors.forename: Pietro
authors.initials: P
authors.lastname: Speziale
authors.forename: Lucio
authors.initials: L
authors.lastname: Montanaro
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development; D004351:Drug Resistance; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D015534:Trans-Activators / Q000378:metabolism; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D018829:Adhesins, Bacterial; C095698:Agr protein, Staphylococcus aureus; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D015534:Trans-Activators; D037521:Virulence Factors; C048165:adhesin, Staphylococcus aureus