title: Beyond base pairs to bedside: a population perspective on how genomics can improve health.
abstract: A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care.  Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of translation.  A population approach should assess the contribution of genomics to health in the context of social and environmental determinants of disease; evaluate genomic applications that may improve health care; design strategies for integrating genomics into practice; address ethical, legal, and social issues; and measure the population health impact of new technologies.
authors.affiliation: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. muk1@cdc.gov
authors.forename: Muin J
authors.initials: MJ
authors.lastname: Khoury
authors.forename: Marta
authors.initials: M
authors.lastname: Gwinn
authors.forename: M Scott
authors.initials: MS
authors.lastname: Bowen
authors.forename: W David
authors.initials: WD
authors.lastname: Dotson
mesh_terms: D003695:Delivery of Health Care; D023281:Genomics / Q000458:organization & administration; D006304:Health Status; D006801:Humans; D057170:Translational Research, Biomedical / Q000458:organization & administration
references.citation: Occup Environ Med. 2008 Jun;65(6):430-6; quiz 436, 397
references.pmid: 18487431
references.citation: PLoS Med. 2010 Oct 12;7(10):
references.pmid: 20967240
references.citation: Adv Exp Med Biol. 2009;646:119-23
references.pmid: 19536670
references.citation: Am J Prev Med. 2011 Apr;40(4):486-93
references.pmid: 21406285
references.citation: Genet Med. 2010 Dec;12(12 Suppl):S256-60
references.pmid: 21150372
references.citation: Genet Med. 2010 Nov;12(11):686-93
references.pmid: 20808229
references.citation: Ann Intern Med. 2005 Sep 6;143(5):362-79
references.pmid: 16144895
references.citation: Am J Public Health. 2002 Jul;92(7):1057-9
references.pmid: 12084677
references.citation: JAMA. 2005 Apr 13;293(14):1729-36
references.pmid: 15827311
references.citation: N Engl J Med. 2011 Feb 10;364(6):524-34
references.pmid: 21226570
references.citation: Genet Med. 2010 Dec;12(12):785-91
references.pmid: 21189494
references.citation: Am J Public Health. 2005 Dec;95(12):2139-43
references.pmid: 16257942
references.citation: Perspect Psychol Sci. 2010 Sep;5(5):527-45
references.pmid: 26162196
references.citation: Public Health Genomics. 2010;13(4):193-6
references.pmid: 20395687
references.citation: Am J Epidemiol. 2005 May 1;161(9):799-805
references.pmid: 15840611
references.citation: Public Health Genomics. 2011;14(1):1-8
references.pmid: 20051673
references.citation: Int J Epidemiol. 2010 Feb;39(1):97-106
references.pmid: 19820105
references.citation: Int J Epidemiol. 2006 Jun;35(3):562-71
references.pmid: 16540539
references.citation: JAMA. 2008 Dec 3;300(21):2542-4
references.pmid: 19050197
references.citation: J Natl Cancer Inst. 2010 Aug 4;102(15):1114-30
references.pmid: 20585105
references.citation: JAMA. 2003 Mar 12;289(10):1278-87
references.pmid: 12633190
references.citation: N Engl J Med. 2009 May 7;360(19):1925-7
references.pmid: 19420360
references.citation: Lancet. 2010 May 1;375(9725):1525-35
references.pmid: 20435227
references.citation: Nature. 2011 Feb 10;470(7333):204-13
references.pmid: 21307933
references.citation: Am J Prev Med. 2010 May;38(5):556-65
references.pmid: 20409503
references.citation: Clin Pharmacol Ther. 2010 Jun;87(6):635-8
references.pmid: 20485318
references.citation: Am J Epidemiol. 2009 Jan 1;169(1):54-66
references.pmid: 18936436
references.citation: Health Aff (Millwood). 2008 Nov-Dec;27(6):1600-11
references.pmid: 18997217
references.citation: Am J Public Health. 2003 Mar;93(3):380-3
references.pmid: 12604476
references.citation: Genet Med. 2007 Oct;9(10):665-74
references.pmid: 18073579
references.citation: Am J Prev Med. 2011 Jan;40(1):61-6
references.pmid: 21146769
references.citation: Genet Med. 2011 Feb;13(2):161-5
references.pmid: 21233720
references.citation: Am J Prev Med. 2008 Aug;35(2 Suppl):S196-203
references.pmid: 18619400
references.citation: Genet Med. 2009 Aug;11(8):559-67
references.pmid: 19617843