title: B-cell pathology in juvenile idiopathic arthritis.
abstract: Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.
authors.affiliation: Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Wiegering
authors.forename: H J
authors.initials: HJ
authors.lastname: Girschick
authors.forename: H
authors.initials: H
authors.lastname: Morbach
references.citation: J Rheumatol. 2004 Feb;31(2):390-2
references.pmid: 14760812
references.citation: Lancet. 2007 Mar 3;369(9563):767-778
references.pmid: 17336654
references.citation: Curr Opin Immunol. 2001 Apr;13(2):195-201
references.pmid: 11228413
references.citation: J Rheumatol. 2000 Oct;27(10):2489-93
references.pmid: 11036848
references.citation: Nat Rev Immunol. 2006 Mar;6(3):205-17
references.pmid: 16498451
references.citation: J Immunol. 2001 Oct 15;167(8):4710-8
references.pmid: 11591802
references.citation: Eur J Immunol. 2005 Dec;35(12):3433-41
references.pmid: 16259010
references.citation: J Immunol. 2000 Nov 15;165(10):5970-9
references.pmid: 11067960
references.citation: Arthritis Rheum. 2008 Jun;58(6):1582-9
references.pmid: 18512774
references.citation: J Immunol. 2001 Jan 1;166(1):377-86
references.pmid: 11123315
references.citation: Nat Immunol. 2010 Jan;11(1):14-20
references.pmid: 20016505
references.citation: J Rheumatol. 2003 Apr;30(4):825-8
references.pmid: 12672206
references.citation: J Rheumatol. 1999 Aug;26(8):1822-6
references.pmid: 10451083
references.citation: Arthritis Rheum. 1990 Sep;33(9):1378-83
references.pmid: 2403401
references.citation: Rheumatology (Oxford). 2007 Jun;46(6):1015-9
references.pmid: 17403710
references.citation: Clin Exp Immunol. 1991 May;84(2):245-9
references.pmid: 1851057
references.citation: J Immunol. 2010 May 1;184(9):4789-800
references.pmid: 20368280
references.citation: J Immunol. 1999 Mar 1;162(5):3053-62
references.pmid: 10072558
references.citation: Mol Immunol. 2008 Aug;45(14):3840-6
references.pmid: 18614233
references.citation: J Rheumatol. 1997 Mar;24(3):560-7
references.pmid: 9058666
references.citation: Rheumatology (Oxford). 2007 Feb;46(2):308-13
references.pmid: 16877460
references.citation: Ann N Y Acad Sci. 2003 Apr;987:246-8
references.pmid: 12727646
references.citation: Arthritis Rheum. 2010 Jun;62(6):1824-8
references.pmid: 20178126
references.citation: Immunol Invest. 2008;37(8):849-57
references.pmid: 18991100
references.citation: J Clin Invest. 2008 Oct;118(10):3420-30
references.pmid: 18802481
references.citation: Rheumatology (Oxford). 2005 Apr;44(4):517-20
references.pmid: 15695302
references.citation: Immunol Rev. 2008 Aug;224:201-14
references.pmid: 18759928
references.citation: Clin Rheumatol. 2002 May;21(2):103-7
references.pmid: 12086158
references.citation: Ann Rheum Dis. 2002 Jul;61(7):608-11
references.pmid: 12079901
references.citation: Clin Immunol Immunopathol. 1995 Jul;76(1 Pt 1):82-9
references.pmid: 7541736
references.citation: BMC Pediatr. 2004 Jul 09;4:13
references.pmid: 15245579
references.citation: Rheumatology (Oxford). 2006 Feb;45(2):204-8
references.pmid: 16188943
references.citation: J Rheumatol. 1994 Nov;21(11):2136-42
references.pmid: 7869324
references.citation: J Autoimmun. 2006 Sep;27(2):81-8
references.pmid: 16934956
references.citation: Arthritis Rheum. 1997 Oct;40(10):1803-9
references.pmid: 9336414
references.citation: Pediatr Int. 2009 Apr;51(2):188-92
references.pmid: 19405913
references.citation: Clin Rev Allergy Immunol. 2007 Feb;32(1):23-36
references.pmid: 17426358
references.citation: Science. 2003 Sep 5;301(5638):1374-7
references.pmid: 12920303
references.citation: Clin Exp Rheumatol. 2002 Mar-Apr;20(2):239-48
references.pmid: 12051407
references.citation: J Rheumatol. 2009 Aug;36(8):1737-43
references.pmid: 19567622
references.citation: Clin Exp Rheumatol. 2004 Jul-Aug;22(4):499-501
references.pmid: 15301253
references.citation: Ann Rheum Dis. 2008 Jul;67(7):1049-51
references.pmid: 18556446
references.citation: Curr Opin Immunol. 2008 Dec;20(6):632-8
references.pmid: 18848883
references.citation: Arthritis Res Ther. 2010;12(1):203
references.pmid: 20236483
references.citation: J Immunol. 2009 Apr 1;182(7):4116-26
references.pmid: 19299709
references.citation: Autoimmunity. 2009 May;42(4):373-5
references.pmid: 19811305
references.citation: Clin Exp Rheumatol. 2010 Sep-Oct;28(5):800
references.pmid: 20822716
references.citation: Blood. 2005 Jun 1;105(11):4390-8
references.pmid: 15701725
references.citation: Nat Rev Rheumatol. 2009 Nov;5(11):616-26
references.pmid: 19806151
references.citation: Curr Rheumatol Rep. 2008 Apr;10(2):156-63
references.pmid: 18460272
references.citation: Arthritis Rheum. 2003 Aug;48(8):2146-54
references.pmid: 12905467
references.citation: J Rheumatol. 2003 Sep;30(9):1900-3
references.pmid: 12966587
references.citation: Pediatr Res. 2009 May;65(5 Pt 2):38R-45R
references.pmid: 19190531
references.citation: J Rheumatol. 2004 Sep;31(9):1829-33
references.pmid: 15338508
references.citation: Ophthalmology. 2008 Oct;115(10):1833-6
references.pmid: 18495247
references.citation: J Rheumatol. 2006 Jan;33(1):164-6
references.pmid: 16395764
references.citation: Arthritis Rheum. 2010 Nov;62(11):3249-58
references.pmid: 20662067
references.citation: Clin Exp Rheumatol. 2002 Sep-Oct;20(5):719-22
references.pmid: 12412208
references.citation: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):221-5
references.pmid: 8552609
references.citation: Arthritis Rheum. 2005 Mar;52(3):826-32
references.pmid: 15751057
references.citation: J Rheumatol. 1991 Mar;18(3):401-8
references.pmid: 1856809
references.citation: Clin Rheumatol. 2009 Dec;28(12):1461-3
references.pmid: 19789936
references.citation: N Engl J Med. 2004 Jun 17;350(25):2572-81
references.pmid: 15201414
references.citation: Arthritis Res Ther. 2006;8(6):R178
references.pmid: 17129378
references.citation: Clin Exp Rheumatol. 2008 May-Jun;26(3):492-7
references.pmid: 18578976
references.citation: Ann Rheum Dis. 2004 Dec;63(12):1687-9
references.pmid: 15547097
references.citation: Arthritis Res Ther. 2009;11(5):R150
references.pmid: 19804628
references.citation: Histol Histopathol. 2000 Jul;15(3):791-8
references.pmid: 10963123
references.citation: J Exp Med. 1998 Aug 17;188(4):765-72
references.pmid: 9705958
references.citation: Clin Rheumatol. 2000;19(3):200-3
references.pmid: 10870654
references.citation: J Immunol. 2009 May 15;182(10):5982-93
references.pmid: 19414749
references.citation: Rheumatology (Oxford). 2006 Nov;45(11):1448-9
references.pmid: 16920752
references.citation: Immunol Rev. 2008 Jun;223:284-99
references.pmid: 18613843
references.citation: Ann Rheum Dis. 2006 Oct;65(10):1351-6
references.pmid: 16504994
references.citation: Scand J Immunol. 2007 Jan;65(1):76-83
references.pmid: 17212770
references.citation: J Immunol. 2008 Jul 1;181(1):785-94
references.pmid: 18566445
references.citation: J Exp Med. 2005 May 16;201(10):1659-67
references.pmid: 15897279
references.citation: Clin Exp Rheumatol. 2006 Jul-Aug;24(4):449-51
references.pmid: 16956438