title: Usefulness of the secretory unit of islet transplant objects (SUITO) index for evaluation of clinical autologous islet transplantation.
abstract: BACKGROUND
  Assessing the engrafted islet mass is important in evaluating the efficacy of islet transplantation. We previously demonstrated that the average secretory unit of islet transplant objects (SUITO) index within 1 month of allogeneic islet transplantation was an excellent predictor of insulin independence. However, the usefulness of the SUITO index for evaluating autologous islet transplantation has not been explored. The purpose of the present study was to assess the relationship between the SUITO index and clinical outcomes after total pancreatectomy followed by autologous islet transplantation.
  
  
  METHODS
  We performed 27 total pancreatectomies followed by autologous islet transplantation from October 2006 to January 2011. Cases were divided into an insulin-independent group (IIG; n = 12) and an insulin-dependent group (lDG; n = 15). The SUITO index was calculated by the formula [fasting C-peptide (ng/mL)/fasting glucose (mg/dL) -63] × 1,500. The average SUITO index within the first month of transplantation except for days 0, 1, and 2, maximum SUITO index, and most recent SUITO index were calculated in each case, and values were compared between the IIG and the IDG.
  
  
  RESULTS
  The average SUITO index within 1 month was significantly higher in the IIG than in the IDG (24.6 ± 3.4 vs 14.9 ± 2.0, respectively; P < .02). The maximum SUITO indices were 45.7 ± 7.7 in the IIG and 30.1 ± 8.1 in the IDG (not significant), and the recent SUITO indices were 36.9 ± 6.7 in the IIG and 22.8 ± 6.1 in the IDG (not significant).
  
  
  CONCLUSIONS
  The average SUITO index within 1 month was an excellent predictor of insulin independence after total pancreatectomy followed by autologous islet transplantation.
authors.affiliation: Baylor Research Institute, Dallas, Texas, USA. shinichi41@mac.com
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Takita
authors.forename: M
authors.initials: M
authors.lastname: Shimoda
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Iwahashi
authors.forename: D
authors.initials: D
authors.lastname: Chujo
authors.forename: J A
authors.initials: JA
authors.lastname: SoRelle
authors.forename: Y
authors.initials: Y
authors.lastname: Tamura
authors.forename: A
authors.initials: A
authors.lastname: Rahman
authors.forename: K
authors.initials: K
authors.lastname: Purcell
authors.forename: N
authors.initials: N
authors.lastname: Onaca
authors.forename: B
authors.initials: B
authors.lastname: Naziruddin
authors.forename: M F
authors.initials: MF
authors.lastname: Levy
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism; D002470:Cell Survival; D003920:Diabetes Mellitus / Q000517:prevention & control; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000166:cytology; D016381:Islets of Langerhans Transplantation / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D012737:Sex Factors; D013997:Time Factors; D014182:Transplantation, Autologous / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin