title: [The relationship between coagulation/anticoagulation imbalance and oxidative stress in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To explore the relationship between coagulation/anticoagulation imbalance and oxidative stress in the patients with chronic obstructive pulmonary disease during acute exacerbation (AECOPD) before and after treatment.
  
  
  METHODS
  Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) activity was detected by chromogenic assay in 28 AECOPD patients before and after treatment as well as in 30 healthy controls. The total antioxidative capacity (TAC), malondialdehyde (MDA) and glutathione peroxidase (GSH-PX) in plasma were measured in both groups.
  
  
  RESULTS
  The levels of plasma TF and TFPI, and their ratio (TF/TFPI) in AECOPD patients before treatment were significantly higher than those after treatment (all P < 0.01), the latter were still higher than those in the healthy persons (all P < 0.01). The levels of the TAC and GSH-PX in plasma in AECOPD patients before treatment were significantly lower than those after treatment (all P < 0.01), the latter were still lower than those in the healthy persons (all P < 0.01). The plasma MDA in AECOPD patients before treatment was significantly higher than that after treatment (P < 0.01), which was still higher than that in the healthy persons (P < 0.05). There were negative correlations between TF/TFPI ratio and TAC (r = -0.518, P < 0.01), GSH-PX (r = -0.454, P < 0.05), PaO2 (r = -0.511, P < 0.01) respectively and a positive correlation between TF/TFPI ratio and the percentage of neutrophils (r = 0.379, P < 0.05) in AECOPD patients before treatment. There still were negative correlations between TF/TFPI ratio and TAC (r = -0.420, P < 0.05), FEV(1)% to predicted (r = -0.480, P < 0.05) respectively, and a positive correlation between TF/TFPI ratio and MDA (r = 0.451, P < 0.05) in AECOPD patients after treatment.
  
  
  CONCLUSIONS
  There existed coagulation/anticoagulation imbalance and oxidation/antioxidation imbalance before and after treatment in AECOPD patients and their relationship was explored.
authors.affiliation: Department of Gerontal Respiratory Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Xiao-ju
authors.initials: XJ
authors.lastname: Liu
authors.forename: Hai-rong
authors.initials: HR
authors.lastname: Bao
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: En-li
authors.initials: EL
authors.lastname: Tan
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Liao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology*; D013925:Thromboplastin / Q000032:analysis
chemical_list: D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D008315:Malondialdehyde; D013925:Thromboplastin; D005979:Glutathione Peroxidase