title: Fatal course of an autochthonous hepatitis E virus infection in a patient with leukemia in Germany.
abstract: An acute infection with hepatitis E virus (HEV) genotype 3 subtype c was diagnosed in a patient with chronic lymphatic B-cell leukemia 6 weeks after the infusion of donor lymphocytes. Despite intensive care the patient died 39 days after admission due to pericardial effusion that was related to acute liver failure. We suggest that diagnostic procedures for detection of HEV infection should be seriously considered for the immunocompromised patient with elevated liver enzymes in the absence of a travel history to HEV endemic countries.
authors.affiliation: Department of Hematology, Oncology and Stem Cell Transplantation, Asklepios Hospital St. Georg, Lohmühlen Strasse 5, 20099 Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Pfefferle
authors.forename: H
authors.initials: H
authors.lastname: Frickmann
authors.forename: M
authors.initials: M
authors.lastname: Gabriel
authors.forename: N
authors.initials: N
authors.lastname: Schmitz
authors.forename: S
authors.initials: S
authors.lastname: Günther
authors.forename: J
authors.initials: J
authors.lastname: Schmidt-Chanasit
mesh_terms: D000208:Acute Disease; D017809:Fatal Outcome; D005858:Germany; D016751:Hepatitis E / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D017710:Lymphocyte Transfusion / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
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