title: Endogenous TWIST expression and differentiation are opposite during human muscle development.
abstract: TWIST is a transcription factor expressed during early embryonic development. In this study we investigate the expression of TWIST during human muscle development. Human TWIST was found to be endogenously expressed in human fetal myoblasts, and its expression decreased during late stages of development. Myoblasts showed an increasing capacity to differentiate in vitro during development. This inversely proportional relation between TWIST and differentiation capacity of myoblasts suggests that TWIST is involved in the regulation of muscle development.
authors.affiliation: Department of Molecular Genetics, Function & Therapy, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
authors.forename: Andrie
authors.initials: A
authors.lastname: Koutsoulidou
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Mastroyiannopoulos
authors.forename: Denis
authors.initials: D
authors.lastname: Furling
authors.forename: James B
authors.initials: JB
authors.lastname: Uney
authors.forename: Leonidas A
authors.initials: LA
authors.lastname: Phylactou
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D047109:Fetal Development / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007231:Infant, Newborn; D024510:Muscle Development / Q000502:physiology*; D009687:Nuclear Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D051879:Twist-Related Protein 1 / Q000096:biosynthesis*
chemical_list: D009687:Nuclear Proteins; C103173:TWIST1 protein, human; D051879:Twist-Related Protein 1