title: Mechanosensing can result from adhesion molecule dynamics.
abstract: When plated onto a substrate, cells spread. Many cell types, including smooth muscle cells and fibroblasts, spread more effectively on stiffer substrates, and a simple empirical relationship has been determined that relates a cell's spread area to the substrate stiffness. In addition, some crawling cells when plated onto a stiff substrate will not migrate onto soft substrate, a process called "durotaxis". Here we show that the resistive force predicted previously for dynamic adhesion molecules can account for both of these mechanosensory effects.
authors.affiliation: Department of Cell Biology and the Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, USA.
authors.forename: Paulina
authors.initials: P
authors.lastname: Krzyszczyk
authors.forename: Charles W
authors.initials: CW
authors.lastname: Wolgemuth
mesh_terms: D000199:Actins / Q000378:metabolism*; D002448:Cell Adhesion; D002465:Cell Movement; D002477:Cells / Q000166:cytology* / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D058105:Polymerization; D011554:Pseudopodia / Q000378:metabolism
chemical_list: D000199:Actins
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