title: Role of endothelin receptor signalling in squamous cell carcinoma.
abstract: Endothelin plays important roles in various physiological functions including             vascular constriction. Recent studies reported that the endothelin receptors ETA             and ETB are highly expressed in lung and skin tumor tissues. In contrast, there             are few reports on endothelin signalling in the proliferation of head and neck             cancer. We found that both ETA and ETB endothelin receptors were overexpressed             in tumor cells of tongue cancer samples by immunohistochemistry. ETA and ETB were             expressed in cultured lingual and esophageal squamous cell carcinoma (SCCs) cell             lines. When both cultured cell lines were treated with an ETA selective antagonist             (BQ123) or an ETB selective antagonist (BQ788), inhibition of cell growth was             observed. Similar results were observed when SCCs were treated with specific siRNA             for the suppression of ETA or ETB. Furthermore, inhibition of the mitogen-activated             protein (MAP) kinase pathway by the treatments with ET receptor antagonists and             siRNA was also observed. These results indicate that endothelin signalling may,             in part, play important roles in cell growth in SCCs through the MAP kinase pathway.
authors.affiliation: Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan. ishimoto@dent.osaka-u.ac.jp
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ishimoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wada
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamanishi
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihama
authors.forename: Tomonao
authors.initials: T
authors.lastname: Aikawa
authors.forename: Masaya
authors.initials: M
authors.lastname: Okura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Kogo
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kamisaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D016232:Endothelins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D009842:Oligopeptides / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics; D044022:Receptor, Endothelin A / Q000235:genetics / Q000378:metabolism*; D044023:Receptor, Endothelin B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014062:Tongue Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D016232:Endothelins; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010880:Piperidines; D034741:RNA, Small Interfering; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; C086539:BQ 788; D002945:Cisplatin; C072247:cyclo(Trp-Asp-Pro-Val-Leu)
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