title: Emerging role of lipid droplets in host/pathogen interactions.
abstract: Lipid droplets (LDs) are highly dynamic cell organelles involved in energy homeostasis and membrane trafficking. Here, we review how select pathogens interact with LDs. Several RNA viruses use host LDs at different steps of their life cycle. Some intracellular bacteria and parasites usurp host LDs or encode their own lipid biosynthesis machinery, thus allowing production of LDs independently of their host. Although many mechanistic details of host/pathogen LD interactions are unknown, a picture emerges in which the unique cellular architecture and energy stored in LDs are important in the replication of diverse pathogens.
authors.affiliation: Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Herker
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D001693:Biological Transport, Active; D004734:Energy Metabolism; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D012328:RNA Viruses / Q000502:physiology*
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