title: Epigenetic modifications in cancer.
abstract: Cancer initiation and progression is controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot be accounted for by genetic alterations alone but also involves epigenetic changes. Epigenetics refers to the study of mechanisms that alter gene expression without altering the primary DNA sequence. Epigenetic mechanisms are heritable and reversible, and include changes in DNA methylation, histone modifications and small noncoding microRNAs (miRNA). Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Aberrant epigenetic modifications probably occur at a very early stage in neoplastic development, and they are widely described as essential players in cancer progression. Recent advances in epigenetics offer a better understanding of the underlying mechanism(s) of carcinogenesis and provide insight into the discovery of putative cancer biomarkers for early detection, disease monitoring, prognosis, and risk assessment. In this review, we summarize the current literature on epigenetic changes causing genetic alterations that are thought to contribute to cancer, and discuss the potential impact of epigenetics future research.
authors.affiliation: Department of Urology, Case Western Reserve University, Case Comprehensive Cancer Center, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kanwal
authors.forename: S
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002843:Chromatin; D006657:Histones; D022661:RNA, Untranslated
references.citation: Leuk Res. 2006 Sep;30(9):1079-83
references.pmid: 16820204
references.citation: J Appl Physiol (1985). 2010 Aug;109(2):598-605
references.pmid: 20203073
references.citation: Mol Cancer Ther. 2009 Jun;8(6):1409-20
references.pmid: 19509247
references.citation: Curr Drug Targets. 2006 Apr;7(4):443-52
references.pmid: 16611031
references.citation: Int J Biochem Cell Biol. 2009 Jan;41(1):87-95
references.pmid: 18834952
references.citation: Curr Genomics. 2008 Sep;9(6):394-408
references.pmid: 19506729
references.citation: Cell. 2007 Feb 23;128(4):707-19
references.pmid: 17320508
references.citation: CMAJ. 2006 Jan 31;174(3):341-8
references.pmid: 16446478
references.citation: Cell. 2007 Feb 23;128(4):693-705
references.pmid: 17320507
references.citation: Nucleic Acids Res. 1995 Aug 25;23(16):3239-43
references.pmid: 7667100
references.citation: Genes Dev. 2009 Sep 15;23(18):2152-65
references.pmid: 19759263
references.citation: Nat Rev Genet. 2009 May;10(5):295-304
references.pmid: 19308066
references.citation: Nat Rev Genet. 2005 Aug;6(8):597-610
references.pmid: 16136652
references.citation: Cancer Res. 2009 Feb 1;69(3):723-7
references.pmid: 19155292
references.citation: Expert Rev Mol Diagn. 2009 Oct;9(7):651-7
references.pmid: 19817550
references.citation: Phys Chem Chem Phys. 2011 Apr 14;13(14):6471-83
references.pmid: 21380473
references.citation: Genome Res. 2009 Jan;19(1):92-105
references.pmid: 18955434
references.citation: Biochemistry. 2004 Jan 20;43(2):540-9
references.pmid: 14717610
references.citation: Biochemistry. 2009 Feb 17;48(6):1361-8
references.pmid: 19161295
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1240-7
references.pmid: 18483346
references.citation: Clin Cancer Res. 2009 Jun 15;15(12):3927-37
references.pmid: 19509173
references.citation: Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R50-9
references.pmid: 17613547
references.citation: Cell Cycle. 2009 Mar 15;8(6):843-52
references.pmid: 19221491
references.citation: Oncogene. 2012 Mar 29;31(13):1609-22
references.pmid: 21860412
references.citation: Int J Cancer. 2007 Apr 15;120(8):1684-8
references.pmid: 17230510
references.citation: N Engl J Med. 2000 Nov 9;343(19):1350-4
references.pmid: 11070098
references.citation: Mol Cancer Res. 2003 Oct;1(12):882-91
references.pmid: 14573789
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2926-31
references.pmid: 20133639
references.citation: Gut. 2009 Nov;58(11):1546-54
references.pmid: 19834118
references.citation: Nat Biotechnol. 2010 Oct;28(10):1057-68
references.pmid: 20944598
references.citation: Carcinogenesis. 2011 May;32(5):772-8
references.pmid: 21349819
references.citation: Cell. 2009 May 15;137(4):647-58
references.pmid: 19409607
references.citation: Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R60-6
references.pmid: 17613548
references.citation: Chromosoma. 2009 Oct;118(5):549-65
references.pmid: 19506892
references.citation: Cell Res. 2011 Mar;21(3):381-95
references.pmid: 21321607
references.citation: Hum Mutat. 2003 Mar;21(3):192-200
references.pmid: 12619105
references.citation: Biochim Biophys Acta. 2009 Sep;1790(9):920-4
references.pmid: 19162126
references.citation: Cell. 1999 Oct 29;99(3):247-57
references.pmid: 10555141
references.citation: Birth Defects Res C Embryo Today. 2009 Dec;87(4):335-50
references.pmid: 19960550
references.citation: J Natl Cancer Inst. 2005 Oct 19;97(20):1498-506
references.pmid: 16234563
references.citation: Hum Mol Genet. 1997 Oct;6(11):1791-801
references.pmid: 9302255
references.citation: Am J Transl Res. 2010 May 15;2(3):254-84
references.pmid: 20589166
references.citation: Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):694-701
references.pmid: 20493980
references.citation: Nat Med. 2011 Mar;17(3):330-9
references.pmid: 21386836
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10
references.pmid: 17890317
references.citation: Nat Biotechnol. 2009 Sep;27(9):858-63
references.pmid: 19684580
references.citation: Nucleic Acids Res. 2002 Aug 15;30(16):3566-73
references.pmid: 12177298
references.citation: Annu Rev Biochem. 2011;80:473-99
references.pmid: 21529160
references.citation: Dis Markers. 2007;23(1-2):105-12
references.pmid: 17325430
references.citation: Nucleic Acids Res. 2004 Aug 09;32(14):4100-8
references.pmid: 15302911
references.citation: Cancer Lett. 2008 Jul 18;266(1):6-11
references.pmid: 18372104
references.citation: Genes Cancer. 2011 Jun;2(6):631-47
references.pmid: 21941619
references.citation: J Clin Oncol. 2006 Jan 10;24(2):268-73
references.pmid: 16330673
references.citation: EMBO Rep. 2011 Jul 01;12(7):647-56
references.pmid: 21660058
references.citation: Nature. 2005 Jun 9;435(7043):834-8
references.pmid: 15944708
references.citation: Curr Pharm Biotechnol. 2007 Dec;8(6):388-400
references.pmid: 18289048
references.citation: Obstet Gynecol Int. 2010;2010:302051
references.pmid: 20671914
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references.pmid: 12434020
references.citation: Genes Dev. 2009 Apr 1;23(7):781-3
references.pmid: 19339683
references.citation: Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20
references.pmid: 20683471
references.citation: Nucleic Acids Res. 2002 Sep 1;30(17):3831-8
references.pmid: 12202768
references.citation: Nat Rev Cancer. 2011 Jul 07;11(8):588-96
references.pmid: 21734722
references.citation: Cell Mol Life Sci. 2009 Feb;66(4):596-612
references.pmid: 18985277
references.citation: Brief Funct Genomics. 2010 Dec;9(5-6):429-43
references.pmid: 21266346
references.citation: Clin Cancer Res. 2009 Jun 15;15(12):3970-7
references.pmid: 19509171
references.citation: Curr Opin Oncol. 2011 Jan;23(1):69-76
references.pmid: 21119515
references.citation: PLoS Genet. 2007 Oct;3(10):2023-36
references.pmid: 17967063
references.citation: J Clin Pathol. 2009 Sep;62(9):771-6
references.pmid: 19734473
references.citation: Mol Cancer. 2006 Nov 08;5:60
references.pmid: 17092350
references.citation: Nat Rev Cancer. 2010 Jul;10(7):457-69
references.pmid: 20574448
references.citation: Nature. 2010 Jan 21;463(7279):360-3
references.pmid: 20054297
references.citation: Int J Cancer. 2010 Jun 1;126(11):2520-33
references.pmid: 19856314