title: Intercepting bacterial indole signaling with flustramine derivatives.
abstract: Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in  Escherichia coli  and  Staphylococcus aureus . We have found dFBr derivatives that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Bunders
authors.forename: Marine J
authors.initials: MJ
authors.lastname: Minvielle
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Worthington
authors.forename: Minoshka
authors.initials: M
authors.lastname: Ortiz
authors.forename: John
authors.initials: J
authors.lastname: Cavanagh
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D004926:Escherichia coli / Q000378:metabolism*; D006842:Hydrocarbons, Brominated / Q000378:metabolism*; D026121:Indole Alkaloids / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D015398:Signal Transduction; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D006842:Hydrocarbons, Brominated; D026121:Indole Alkaloids; D007211:Indoles; C524215:desformylflustrabromine
references.citation: ISME J. 2008 Oct;2(10):1007-23
references.pmid: 18528414
references.citation: J Mol Biol. 2007 Oct 12;373(1):11-26
references.pmid: 17765265
references.citation: Int J Med Microbiol. 2006 Apr;296(2-3):149-61
references.pmid: 16503194
references.citation: J Antimicrob Chemother. 2004 Jun;53(6):1054-61
references.pmid: 15117922
references.citation: FEMS Microbiol Rev. 2010 Jul;34(4):426-44
references.pmid: 20070374
references.citation: J Am Chem Soc. 2009 Nov 4;131(43):15584-5
references.pmid: 19824634
references.citation: Emerg Infect Dis. 2007 Dec;13(12):1840-6
references.pmid: 18258033
references.citation: Trends Biotechnol. 2011 Feb;29(2):87-94
references.pmid: 21131080
references.citation: J Am Chem Soc. 2005 Sep 21;127(37):12762-3
references.pmid: 16159245
references.citation: J Bacteriol. 2007 Dec;189(24):9066-75
references.pmid: 17933888
references.citation: Chem Commun (Camb). 2009 Dec 7;(45):7033-5
references.pmid: 19904385
references.citation: Microbiology (Reading). 2002 Jan;148(Pt 1):87-102
references.pmid: 11782502
references.citation: Clin Infect Dis. 2008 Jan 15;46(2):155-64
references.pmid: 18171244
references.citation: Chem Biol Drug Des. 2009 Jul;74(1):51-6
references.pmid: 19519744
references.citation: Antimicrob Agents Chemother. 2010 May;54(5):2112-8
references.pmid: 20211901
references.citation: J Bacteriol. 2009 Jun;191(11):3504-16
references.pmid: 19329638
references.citation: Org Lett. 2007 Jan 18;9(2):283-6
references.pmid: 17217285
references.citation: J Am Chem Soc. 2008 Jul 23;130(29):9200-1
references.pmid: 18576653
references.citation: Bioorg Med Chem. 2003 Jul 31;11(15):3261-71
references.pmid: 12837536
references.citation: BMC Microbiol. 2007 May 18;7:42
references.pmid: 17511876
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1213-22
references.pmid: 17360273
references.citation: Chem Biol. 2003 Jan;10(1):81-9
references.pmid: 12573701