title: Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling.
abstract: A unified, convenient, and efficient strategy for the preparation of rhodamines and N,N'-diacylated rhodamines has been developed. Fluorescein ditriflates were found to undergo palladium-catalyzed C-N cross-coupling with amines, amides, carbamates, and other nitrogen nucleophiles to provide direct access to known and novel rhodamine derivatives, including fluorescent dyes, quenchers, and latent fluorophores.
authors.affiliation: Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Grimm
authors.forename: Luke D
authors.initials: LD
authors.lastname: Lavis
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D005452:Fluoresceins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012235:Rhodamines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005452:Fluoresceins; D005456:Fluorescent Dyes; D012235:Rhodamines; D010165:Palladium
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