title: Impaired mitophagy at the heart of injury.
abstract: Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover.
authors.affiliation: Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA. robbieg@sciences.sdsu.edu
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Gottlieb
authors.forename: Robert M
authors.initials: RM
authors.lastname: Mentzer
authors.forename: Phyllis-Jean
authors.initials: PJ
authors.lastname: Linton
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D007249:Inflammation; D051379:Mice; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D008954:Models, Biological; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011494:Protein Kinases / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein
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