title: Lysosomal function and dysfunction: mechanism and disease.
abstract: CONCLUSIONS
  Lysosomes are organelles in which cellular degradation occurs in a controlled manner, separated from other cellular components. As several pathways terminate in the lysosome, lysosomal dysfunction has a profound impact on cell homeostasis, resulting in manifold pathological situations, including infectious diseases, neurodegeneration, and aging.
  
  
  BACKGROUND
  Lysosomal biology demonstrates that in addition to regulating the final steps of catabolic processes, lysosomes are essential up-stream modulators of autophagy and other essential lysosomal pathways.
  Lysosomal membrane permeabilization offers therapeutic potential in the treatment of cancer, though the molecular regulators of this process remain obscure. This review focuses on recent discoveries in lysosomal function and dysfunction, primarily in in vivo situations.
authors.affiliation: Department of Cell Proliferation and Development, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain. patricia.boya@csic.es
authors.forename: Patricia
authors.initials: P
authors.lastname: Boya
mesh_terms: D017209:Apoptosis; D006706:Homeostasis; D006801:Humans; D008247:Lysosomes / Q000502:physiology*