title: Thermal intravascular photoacoustic imaging.
abstract: Intravascular photoacoustics (IVPA)-a minimally invasive imaging technique with contrast related to optical absorption properties of tissue, can be used to visualize atherosclerotic plaques. However, the amplitude of photoacoustic signals is also related to a temperature dependent, tissue specific parameter-the Grüneisen parameter. Therefore, photoacoustic signals measured at different temperatures may reveal information about tissue composition. In this study, thermal IVPA (tIVPA) imaging was introduced. The imaging studies were performed using an ex vivo atherosclerotic rabbit aorta. Temperature dependent photoacoustic responses from lipid in plaques and lipid in periadventitial tissue were different, thus allowing tIVPA images to delineate the location of lipid-rich plaques. The results indicate that tIVPA imaging has a potential to characterize tissue composition in atherosclerotic vessels.
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712,  USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
references.citation: Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 May;59(5 Pt B):5772-89
references.pmid: 11969559
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2007 May;54(5):978-86
references.pmid: 17523562
references.citation: Prog Cardiovasc Dis. 2002 Mar-Apr;44(5):349-56
references.pmid: 12024333
references.citation: Arch Pathol Lab Med. 2007 Mar;131(3):481-7
references.pmid: 17516753
references.citation: Circulation. 2002 Oct 22;106(17):2200-6
references.pmid: 12390948
references.citation: J Biomed Biotechnol. 2011;2011:406473
references.pmid: 21541231
references.citation: Opt Express. 2008 Mar 3;16(5):3362-7
references.pmid: 18542427
references.citation: Nano Lett. 2009 Jun;9(6):2212-7
references.pmid: 18844426
references.citation: Atherosclerosis. 2009 Nov;207(1):1-7
references.pmid: 19389675
references.citation: Opt Lett. 2011 Mar 1;36(5):597-9
references.pmid: 21368919
references.citation: J Lipid Res. 2004 Sep;45(9):1583-93
references.pmid: 15102877
references.citation: J Biomed Opt. 2008 May-Jun;13(3):034024
references.pmid: 18601569
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2005 May;52(5):844-50
references.pmid: 16048186
references.citation: Opt Express. 2010 Mar 1;18(5):4889-97
references.pmid: 20389501
references.citation: Phys Med Biol. 1997 Jan;42(1):177-98
references.pmid: 9015817
references.citation: Circulation. 2001 Jan 30;103(4):604-16
references.pmid: 11157729
references.citation: Arteriosclerosis. 1982 Nov-Dec;2(6):467-74
references.pmid: 6960858
references.citation: J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C7-12
references.pmid: 16631513
references.citation: Circulation. 2002 Apr 9;105(14):1627-30
references.pmid: 11940537