title: Chromosomal abnormalities as a cause of recurrent abortions in Egypt.
abstract: BACKGROUND
  In 4%-8% of couples with recurrent abortion, at least one of the partners has chromosomal abnormality. Most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. These chromosomal abnormalities may be either numerical or structural.
  
  
  METHODS
  Cytogenetic study was done for 73 Egyptian couples who presented with recurrent abortion at Genetic Unit of Children Hospital, Mansoura University.
  
  
  RESULTS
  We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 9 (6.1%) of 73 couples. Seven of chromosomal abnormalities were structural and two of them were numerical.
  
  
  CONCLUSIONS
  Our results showed that 6.1% of the couples with recurrent abortion had chromosomal abnormalities, with no other abnormalities. We suggest that it is necessary to perform cytogenetic in vestigation for couples who have recurrent abortion.
authors.affiliation: Department of Genetics Unit of Children Hospital, Mansoura University, Mansoura, Egypt.
authors.forename: Faeza Abdel Mogib
authors.initials: FA
authors.lastname: El-Dahtory
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