title: Canine cutaneous perivascular wall tumors at first presentation: clinical behavior and prognostic factors in 55 cases.
abstract: BACKGROUND
  Canine cutaneous perivascular wall tumors (c-PWT) are soft tissue sarcomas recently identified when hemangiopericytomas were reclassified. No previous clinical data are available for c-PWT.
  
  
  OBJECTIVE
  To define the clinical behavior and prognostic role of clinical and pathological variables in a homogeneous population of c-PWT.
  
  
  METHODS
  Fifty-five c-PWT in 53 client-owned dogs at first presentation undergoing surgery.
  
  
  METHODS
  Retrospective case series. The endpoint was the relapse of tumor (local and/or distant). The prognostic values of clinical (age, sex, weight, site and tumor size, adjuvant therapy) and pathological (status of surgical margins, histological grade, mitosis, percentage of tumor necrosis) variables were investigated by univariate and bivariate analyses (P < .05). The pattern of associations between variables was explored by multivariate correspondence analysis (MCA).
  
  
  RESULTS
  Twelve dogs had a relapse. Ten dogs had local recurrence, 1 had metastatic disease, and 1 had both. The estimated probability of local recurrence was 0.02, 0.08, 0.20, and 0.24 at 6 months, 1, 2, and 3 years, respectively. Size of the tumor was a significant prognostic factor while status of margins had only a clinically relevant hazard ratio. In MCA evaluation, young age, tumor size (< 5 cm), grade I, and location in the extremities were associated. Association was also observed for older age, tumor size (> 5 cm), grade II, and other location.
  
  
  CONCLUSIONS
  C-PWT tend to locally recur a long time after surgery. An early diagnosis of c-PWT associated with small tumor size (< 5 cm) and clean surgical margins ensures a good prognosis independently of histological grade.
authors.affiliation: Dipartimento di Scienze Cliniche Veterinarie, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy. damiano.stefanello@unimi.it
authors.forename: D
authors.initials: D
authors.lastname: Stefanello
authors.forename: G
authors.initials: G
authors.lastname: Avallone
authors.forename: R
authors.initials: R
authors.lastname: Ferrari
authors.forename: P
authors.initials: P
authors.lastname: Roccabianca
authors.forename: P
authors.initials: P
authors.lastname: Boracchi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D009383:Neoplasms, Vascular Tissue / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology / Q000662:veterinary; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*