title: Preparation and investigation of bioactive transferrin-iron complexes formed with different synergistic anions.
abstract: Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions. The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin. The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters.
authors.affiliation: Applied Chemistry and Material Science, Politehnica University of Bucharest, 010737, Bucharest, Romania. galiczajudit@yahoo.com
authors.forename: Judit
authors.initials: J
authors.lastname: Gálicza
authors.forename: Andrea
authors.initials: A
authors.lastname: Vargová
authors.forename: Viktor
authors.initials: V
authors.lastname: Sándor
authors.forename: Csongor Kálmán
authors.initials: CK
authors.lastname: Orbán
authors.forename: Csaba Dezso
authors.initials: CD
authors.lastname: András
authors.forename: Beáta
authors.initials: B
authors.lastname: Abrahám
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Lányi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Kilár
mesh_terms: D000818:Animals; D000838:Anions / Q000737:chemistry* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001388:Aziridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001692:Biological Transport; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D019075:Electrophoresis, Capillary; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D007525:Isoelectric Focusing; D010070:Oxalates / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D014168:Transferrin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000838:Anions; D000970:Antineoplastic Agents; D001388:Aziridines; D010070:Oxalates; D014168:Transferrin; C073440:aziridine-2-carboxylic acid; D007501:Iron
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