title: [The present state of the clinical and epidemiologic research on chemical and carcinogenic risks in the metalworking industry].
abstract: In this report several publications on clinical-epidemiologic patterns are presented regarding chemical and oncogenic risk in the metalworking industry. Sources of information were mainly PubMed and TOXNET. As far as cancer is concerned the body of the epidemiological data is difficult to interpret, mainly due to the fact that even the most recent papers and reviews refer to past exposure to MWF. Moreover, the great number of cancer sites are hardly explainable as to the biological plausibility. However, it is likely that current problems might be overcome by the almost total elimination of PAH and some additives. Moreover, cancer risk for welders and painters should be considered according to the different techniques used. Several studies reported repeated outbreaks of Hypersensitivity Pneumonitis, especially in US, most probably caused by mycobacterial antigens present in water-based oils. In Italy this disease is probably misdiagnosed or underreported. Some cross-sectional studies on respiratory disease and hearing loss, caused by the interaction of noise and chemical agent (mainly solvents), provided limited information because of the nature itself of this type of studies. Dermal pathologies still affect MWF exposed workers. Some antigens present in compounds, which are now gradually substituted, have been identified for allergic dermatitis (ADC).
authors.affiliation: Dipartimento di Traumatologia, Ortopedia e Medicina del Lavoro dell'Università degli Studi di Torino, CTO - Via Zuretti n. 29 10126 Torino. giorgio.piolatto@unito.it
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Piolatto
authors.forename: Simona
authors.initials: S
authors.lastname: Catalani
mesh_terms: D035843:Biomedical Research; D006801:Humans; D008669:Metallurgy; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000453:epidemiology; D012307:Risk Factors