title: Translocation (5; 11) in a conjunctival MALT lymphoma.
abstract: Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunopheno-typic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lym-phomas and ocular MALT lymphomas as well.
authors.affiliation: Departments of Pathology, University of Texas Medical Branch, Galveston, USA.
authors.forename: Cecilia G
authors.initials: CG
authors.lastname: Clement
authors.forename: Venkateswara R
authors.initials: VR
authors.lastname: Potluri
authors.forename: John
authors.initials: J
authors.lastname: Gonzales
authors.forename: You-Wen
authors.initials: YW
authors.lastname: Qian
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor
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