title: International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.
abstract: Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.
authors.affiliation: Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, Mission Bay Campus, San Francisco, CA 94158-2811, USA.
authors.forename: Fen
authors.initials: F
authors.lastname: Huang
authors.forename: Xiuming
authors.initials: X
authors.lastname: Wong
authors.forename: Lily Y
authors.initials: LY
authors.lastname: Jan
mesh_terms: D000818:Animals; D000075369:Anoctamin-1; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000145:classification / Q000502:physiology*; D055724:Electrophysiological Phenomena; D006031:Glycosylation; D006801:Humans; D007390:International Agencies; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000145:classification / Q000502:physiology*; D009928:Organ Specificity; D010766:Phosphorylation; D011487:Protein Conformation; D009626:Terminology as Topic; D029867:Xenopus Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000145:classification / Q000502:physiology*
chemical_list: C476213:ANO1 protein, human; C531181:ANO1 protein, mouse; D000075369:Anoctamin-1; D018118:Chloride Channels; D009363:Neoplasm Proteins; D029867:Xenopus Proteins; C559904:xANO2 protein, Xenopus
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