title: Applying the PRECIS criteria to describe three effectiveness trials of weight loss in obese patients with comorbid conditions.
abstract: OBJECTIVE
  To characterize Practice-Based Opportunities for Weight Reduction (POWER) trials along the pragmatic-explanatory continuum.
  
  
  METHODS
  The POWER trials consist of three individual studies that target obesity treatment in primary care settings.
  
  
  METHODS
  Using the PRagmatic Explanatory Continuum Indicator Summary (PRECIS) criteria, nine reviewers independently scored each trial.
  
  
  METHODS
  Average and median ratings, inter-rater reliability, and relationships to additional ratings of the extent to which study designs were explanatory (i.e., efficacy) versus pragmatic (i.e., practical) and related to external validity were determined.
  
  
  RESULTS
  One trial was consistently rated as being significantly more pragmatic than the others (R(2) =0.43, p< .001), although all three were in the moderate range on the PRECIS scales. Ratings varied across PRECIS dimensions, being most pragmatic on comparison condition and primary outcome. Raters, although undergoing training and using identical definitions, scored their own study as more pragmatic than the other studies/interventions.
  
  
  CONCLUSIONS
  These results highlight the need for more comprehensive reporting on PRECIS and related criteria for research translation. The PRECIS criteria provide a richer understanding of the POWER studies. It is not clear whether the original criteria are sufficient to provide a comprehensive profile.
authors.affiliation: Dissemination and Implementation Science, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd., Room 6144, Rockville, MD 20852, USA. glasgowre@mail.nih.gov
authors.forename: Russell E
authors.initials: RE
authors.lastname: Glasgow
authors.forename: Bridget
authors.initials: B
authors.lastname: Gaglio
authors.forename: Gary
authors.initials: G
authors.lastname: Bennett
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Jerome
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Yeh
authors.forename: David B
authors.initials: DB
authors.lastname: Sarwer
authors.forename: Lawrence
authors.initials: L
authors.lastname: Appel
authors.forename: Graham
authors.initials: G
authors.lastname: Colditz
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wadden
authors.forename: Barbara
authors.initials: B
authors.lastname: Wells
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D030881:Disclosure; D006801:Humans; D009765:Obesity / Q000453:epidemiology / Q000534:rehabilitation*; D017712:Peer Review, Research / Q000379:methods*; D011320:Primary Health Care; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012107:Research Design; D058028:Research Report; D014481:United States; D015431:Weight Loss
references.citation: Obes Weight Manag. 2009 Oct;5(5):216-221
references.pmid: 34745430
references.citation: Ann Behav Med. 2006 Feb;31(1):5-13
references.pmid: 16472033
references.citation: CMAJ. 2009 May 12;180(10):E47-57
references.pmid: 19372436
references.citation: JAMA. 2003 Sep 24;290(12):1624-32
references.pmid: 14506122
references.citation: Ann Behav Med. 1996 Fall;18(4):290-304
references.pmid: 18425675
references.citation: Am J Prev Med. 1998 Nov;15(4):413-30
references.pmid: 9838981
references.citation: Ann Behav Med. 2004 Feb;27(1):3-12
references.pmid: 14979858
references.citation: Ann Behav Med. 2008 Feb;35(1):19-25
references.pmid: 18347901
references.citation: N Engl J Med. 2003 Jun 26;348(26):2635-45
references.pmid: 12826639
references.citation: BMJ. 2008 Nov 11;337:a2390
references.pmid: 19001484
references.citation: Lancet. 2005 Jan 1-7;365(9453):82-93
references.pmid: 15639683
references.citation: N Engl J Med. 2005 Oct 13;353(15):1621-3
references.pmid: 16221788
references.citation: Am J Prev Med. 2007 Aug;33(2):139-154
references.pmid: 17673103
references.citation: Clin Trials. 2010 Aug;7(4):322-32
references.pmid: 20573639