title: [Effect of qufeng zhidong simplified recipe on the behavior of the tic disorder rats].
abstract: OBJECTIVE
  To study the effects qufeng zhidong Simplified Recipe (QZSR) on the behavior of the tic disorder (TD) rats.
  
  
  METHODS
  Fifty male SD rats were randomly divided to the normal group, the model group, the QZSR-1 group, the QZSR-2 group, and the QZSR group, 10 in each group. Two mg/kg apomorphine (APO) was intraperitoneally injected to rats in the model group, the QZSR-1 group, the QZSR-2 group, and the QZSR group, while equal volume of normal saline was intraperitoneally injected to rats in the normal group, both once daily for 7 successive weeks. At the 4th week equal volume of normal saline was intraperitoneally injected to rats in the model group and the normal group, while corresponding medicinal liquid was intraperitoneally injected to those in the rest groups, both once daily for 7 successive weeks. At the 2nd and 4th week of intervention, rats' improvement degrees of stereotyped behavior and the open-field test were monitored, and their experimental results were analyzed.
  
  
  RESULTS
  At the 2nd and 4th week of intervention, when compared with those of the model group, the score of stereotyped behavior decreased, the numbers of passing-panel, straightening, and dejecta pill were reduced, and the number of grooming increased in the QZSR-1 group, the QZSR-2 group, and the QZSR group. But there was no difference among the three groups (P>0.05).
  
  
  CONCLUSIONS
  QZSR could significantly reduce APO induced stereotyped behavior scores of TD rats, improve their locomotor activities, and reinforce their adaptive faculty.
authors.affiliation: Department of Chinese Medicine, Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai. xinhuayiyuan123@126.com
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Bi-tao
authors.initials: BT
authors.lastname: Ma
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Wang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013981:Tic Disorders / Q000188:drug therapy* / Q000523:psychology*
chemical_list: D004365:Drugs, Chinese Herbal; C545315:qufeng zhidong