title: Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil.
abstract: The chemical composition and the in vitro schistosomicidal effects of the essential oil of Plectranthus neochilus (PN-EO) grown in Southeast Brazil was studied. β-Caryophyllene (1; 28.23%), α-thujene (2; 12.22%), α-pinene (3; 12.63%), β-pinene (4; 6.19%), germacrene D (5; 5.36%), and caryophyllene oxide (6; 5.37%) were the major essential oil constituents. This chemical composition differed from that previously reported for specimens harvested in Africa. Concerning the in vitro schistosomicidal activity against adult Schistosoma mansoni worms, PN-EO was considered to be active, but less effective than the positive control praziquantel (PZQ) in terms of separation of coupled pairs, mortality, decrease in the motor activity, and tegumental alterations. However, PN-EO caused an interesting dose-dependent reduction in the number and the percentage of developed S. mansoni eggs. These results suggest that PN-EO might be very promising for the development of new schistosomicidal agents.
authors.affiliation: Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil.
authors.forename: Soraya C
authors.initials: SC
authors.lastname: Caixeta
authors.forename: Lizandra G
authors.initials: LG
authors.lastname: Magalhães
authors.forename: Nathalya I
authors.initials: NI
authors.lastname: de Melo
authors.forename: Kamila A L
authors.initials: KA
authors.lastname: Wakabayashi
authors.forename: Gabriela de P
authors.initials: Gde P
authors.lastname: Aguiar
authors.forename: Daniela de P
authors.initials: Dde P
authors.lastname: Aguiar
authors.forename: André L L
authors.initials: AL
authors.lastname: Mantovani
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Alves
authors.forename: Pollyanna F
authors.initials: PF
authors.lastname: Oliveira
authors.forename: Denise C
authors.initials: DC
authors.lastname: Tavares
authors.forename: Milton
authors.initials: M
authors.lastname: Groppo
authors.forename: Vanderlei
authors.initials: V
authors.lastname: Rodrigues
authors.forename: Wilson R
authors.initials: WR
authors.lastname: Cunha
authors.forename: Rodrigo C S
authors.initials: RC
authors.lastname: Veneziani
authors.forename: Ademar A
authors.initials: AA
authors.lastname: da Silva Filho
authors.forename: Antônio E M
authors.initials: AE
authors.lastname: Crotti
mesh_terms: D000818:Animals; D001938:Brazil; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry / Q000254:growth & development; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031346:Plectranthus / Q000737:chemistry* / Q000254:growth & development; D012550:Schistosoma mansoni / Q000187:drug effects / Q000254:growth & development; D012556:Schistosomicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D009822:Oils, Volatile; D010938:Plant Oils; D012556:Schistosomicides