title: Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis.
abstract: The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
authors.affiliation: Departments of Diagnostic & Interventional Imaging, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Khader.M.Hasan@uth.tmc.edu
authors.forename: Khader M
authors.initials: KM
authors.lastname: Hasan
authors.forename: Indika S
authors.initials: IS
authors.lastname: Walimuni
authors.forename: Humaira
authors.initials: H
authors.lastname: Abid
authors.forename: Richard E
authors.initials: RE
authors.lastname: Frye
authors.forename: Linda
authors.initials: L
authors.lastname: Ewing-Cobbs
authors.forename: Jerry S
authors.initials: JS
authors.lastname: Wolinsky
authors.forename: Ponnada A
authors.initials: PA
authors.lastname: Narayana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001931:Brain Mapping; D002648:Child; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000473:pathology*; D013788:Thalamus / Q000033:anatomy & histology* / Q000254:growth & development*; D055815:Young Adult
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