title: Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects.
abstract: We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-γ and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties.
authors.affiliation: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despota Stefana 142 11000 Belgrade, Serbia. georgije_zw@yahoo.com
authors.forename: Djordje
authors.initials: D
authors.lastname: Miljković
authors.forename: Jelena M
authors.initials: JM
authors.lastname: Poljarević
authors.forename: Filip
authors.initials: F
authors.lastname: Petković
authors.forename: Jana
authors.initials: J
authors.lastname: Blaževski
authors.forename: Miljana
authors.initials: M
authors.lastname: Momčilović
authors.forename: Ivana
authors.initials: I
authors.lastname: Nikolić
authors.forename: Tamara
authors.initials: T
authors.lastname: Saksida
authors.forename: Stanislava
authors.initials: S
authors.lastname: Stošić-Grujičić
authors.forename: Sanja
authors.initials: S
authors.lastname: Grgurić-Šipka
authors.forename: Tibor J
authors.initials: TJ
authors.lastname: Sabo
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003959:Diamines / Q000737:chemistry*; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D008024:Ligands; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D003959:Diamines; D007155:Immunologic Factors; D020381:Interleukin-17; D008024:Ligands; D009942:Organometallic Compounds; D009569:Nitric Oxide; D010984:Platinum; D007371:Interferon-gamma