title: Spiking signatures of spontaneous activity bursts in hippocampal cultures.
abstract: Dense dissociated hippocampal cultures are known to generate spontaneous bursting electrical activity which can be recorded by multielectrode arrays. We have analyzed spatio-temporal profiles of the distribution of spikes in the bursts recorded after 2 weeks in vitro. We have found a statistically significant similarity between the spiking patterns in sequential bursting events, we refer to these spiking patterns as spiking signatures. Such spiking signatures may appear in different parts of the bursts, including the activation patterns - the first spike times in the bursts, and deactivation patterns - the last spike times in the bursts. Moreover, these patterns may display apparent time scaling, e.g., they may be replayed in the subsequent bursts at different speeds, while preserving the spiking order. We discuss how such properties of the bursts may be associated with the formation of repeatable signaling pathways in cultured networks in vitro.
authors.affiliation: Department of Neurodynamics and Neurobiology, Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Pimashkin
authors.forename: Innokentiy
authors.initials: I
authors.lastname: Kastalskiy
authors.forename: Alexander
authors.initials: A
authors.lastname: Simonov
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Koryagina
authors.forename: Irina
authors.initials: I
authors.lastname: Mukhina
authors.forename: Victor
authors.initials: V
authors.lastname: Kazantsev
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