title: Effect of auditory input on activations in infant diverse cortical regions during audiovisual processing.
abstract: A fundamental question with regard to perceptual development is how multisensory information is processed in the brain during the early stages of development. Although a growing body of evidence has shown the early emergence of modality-specific functional differentiation of the cortical regions, the interplay between sensory inputs from different modalities in the developing brain is not well understood. To study the effects of auditory input during audio-visual processing in 3-month-old infants, we evaluated the spatiotemporal cortical hemodynamic responses of 50 infants while they perceived visual objects with or without accompanying sounds. The responses were measured using 94-channel near-infrared spectroscopy over the occipital, temporal, and frontal cortices. The effects of sound manipulation were pervasive throughout the diverse cortical regions and were specific to each cortical region. Visual stimuli co-occurring with sound induced the early-onset activation of the early auditory region, followed by activation of the other regions. Removal of the sound stimulus resulted in focal deactivation in the auditory regions and reduced activation in the early visual region, the association region of the temporal and parietal cortices, and the anterior prefrontal regions, suggesting multisensory interplay. In contrast, equivalent activations were observed in the lateral occipital and lateral prefrontal regions, regardless of sound manipulation. Our findings indicate that auditory input did not generally enhance overall activation in relation to visual perception, but rather induced specific changes in each cortical region. The present study implies that 3-month-old infants may perceive audio-visual multisensory inputs by using the global network of functionally differentiated cortical regions.
authors.affiliation: Graduate School of Education, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hama@p.u-tokyo.ac.jp
authors.forename: Hama
authors.initials: H
authors.lastname: Watanabe
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Homae
authors.forename: Tamami
authors.initials: T
authors.lastname: Nakano
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuzuki
authors.forename: Lkhamsuren
authors.initials: L
authors.lastname: Enkhtur
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nemoto
authors.forename: Ippeita
authors.initials: I
authors.lastname: Dan
authors.forename: Gentaro
authors.initials: G
authors.lastname: Taga
mesh_terms: D000161:Acoustic Stimulation; D001306:Auditory Pathways / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010108:Oxyhemoglobins / Q000378:metabolism; D010775:Photic Stimulation; D013016:Sound; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*; D014851:Wakefulness
chemical_list: D010108:Oxyhemoglobins
references.citation: Neuroimage. 2007 Feb 15;34(4):1506-18
references.pmid: 17207638
references.citation: J Neurosci. 2006 Jan 4;26(1):273-8
references.pmid: 16399697
references.citation: Cogn Psychol. 1979 Oct;11(4):478-84
references.pmid: 487747
references.citation: Neuron. 2007 Aug 2;55(3):521-32
references.pmid: 17678862
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14240-5
references.pmid: 16968771
references.citation: Exp Brain Res. 2005 Oct;166(3-4):559-71
references.pmid: 16028028
references.citation: Science. 2002 Sep 6;297(5587):1706-8
references.pmid: 12215648
references.citation: Cereb Cortex. 2009 Feb;19(2):455-63
references.pmid: 18544555
references.citation: Med Phys. 1995 Dec;22(12):1997-2005
references.pmid: 8746704
references.citation: PLoS One. 2011 Apr 14;6(4):e18746
references.pmid: 21533194
references.citation: Dev Psychol. 2000 Mar;36(2):190-201
references.pmid: 10749076
references.citation: Nat Rev Neurosci. 2002 Mar;3(3):243-9
references.pmid: 11994756
references.citation: Cogn Affect Behav Neurosci. 2004 Jun;4(2):137-47
references.pmid: 15460921
references.citation: Neuroimage. 2005 Jul 15;26(4):1184-92
references.pmid: 15961052
references.citation: Neuroimage. 2007 Jan 1;34(1):399-406
references.pmid: 16997577
references.citation: Neuroimage. 2008 Dec;43(4):721-30
references.pmid: 18761410
references.citation: Neuroreport. 1999 Aug 20;10(12):2619-23
references.pmid: 10574380
references.citation: Nat Rev Neurosci. 2004 Mar;5(3):218-28
references.pmid: 14976521
references.citation: Neuron. 2000 Mar;25(3):717-28
references.pmid: 10774738
references.citation: Nat Neurosci. 2002 Sep;5(9):905-9
references.pmid: 12195426
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: Brain. 1999 May;122 ( Pt 5):883-93
references.pmid: 10355673
references.citation: Cereb Cortex. 2007 Jul;17(7):1672-9
references.pmid: 16968869
references.citation: Neuroimage. 2008 Nov 1;43(2):346-57
references.pmid: 18691660
references.citation: Trends Neurosci. 2008 Aug;31(8):401-9
references.pmid: 18602171
references.citation: Neuron. 2008 Jan 10;57(1):11-23
references.pmid: 18184561
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11800-6
references.pmid: 11050212
references.citation: Cereb Cortex. 2002 Nov;12(11):1202-12
references.pmid: 12379608
references.citation: Cereb Cortex. 2001 Apr;11(4):298-311
references.pmid: 11278193
references.citation: Neuron. 2004 Mar 4;41(5):809-23
references.pmid: 15003179
references.citation: Nat Rev Neurosci. 2003 Mar;4(3):165-78
references.pmid: 12612630
references.citation: J Neurophysiol. 2004 Apr;91(4):1699-705
references.pmid: 15010496
references.citation: Early Hum Dev. 1986 Dec;14(3-4):233-8
references.pmid: 3803269
references.citation: J Cogn Neurosci. 2002 Apr 1;14(3):420-9
references.pmid: 11970801
references.citation: Phys Med Biol. 2007 Dec 7;52(23):6849-64
references.pmid: 18029979
references.citation: Neuroimage. 2005 Oct 1;27(4):842-51
references.pmid: 15979346
references.citation: Neuroimage. 2004 Jan;21(1):99-111
references.pmid: 14741647
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Psychol Bull. 2000 Mar;126(2):260-80
references.pmid: 10748643
references.citation: J Neurosci. 2010 Apr 7;30(14):4877-82
references.pmid: 20371807
references.citation: Neurosci Res. 2007 Sep;59(1):29-39
references.pmid: 17590470
references.citation: J Exp Psychol Hum Percept Perform. 1996 Oct;22(5):1094-106
references.pmid: 8865617
references.citation: Pediatr Res. 1998 Jun;43(6):840-3
references.pmid: 9621996
references.citation: Annu Rev Neurosci. 2004;27:649-77
references.pmid: 15217346
references.citation: Neuron. 1998 Jul;21(1):191-202
references.pmid: 9697863
references.citation: Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8135-9
references.pmid: 7667258
references.citation: Neuroimage. 2007 Jul 15;36(4):1246-52
references.pmid: 17524672
references.citation: Neuroimage. 2005 May 15;26(1):18-28
references.pmid: 15862201
references.citation: Neuroimage. 2007 Jan 1;34(1):407-15
references.pmid: 17045812
references.citation: Hum Brain Mapp. 2004 Apr;21(4):213-20
references.pmid: 15038003
references.citation: Infant Behav Dev. 2006 Jul;29(3):402-22
references.pmid: 17138294
references.citation: J Neurosci. 2008 May 14;28(20):5344-9
references.pmid: 18480290
references.citation: J Biomed Opt. 2005 Jan-Feb;10(1):11010
references.pmid: 15847576
references.citation: Br Med Bull. 1988 Oct;44(4):1052-75
references.pmid: 3076826
references.citation: Trends Neurosci. 1997 Oct;20(10):435-42
references.pmid: 9347608
references.citation: Science. 2001 Aug 24;293(5534):1506-9
references.pmid: 11520991
references.citation: Infant Behav Dev. 2009 Jan;32(1):79-90
references.pmid: 19081637
references.citation: Neuroimage. 2007 Nov 15;38(3):452-60
references.pmid: 17884584
references.citation: Neuroimage. 2006 Nov 1;33(2):542-9
references.pmid: 16959498
references.citation: J Neurosci. 2010 Feb 10;30(6):2268-76
references.pmid: 20147553
references.citation: Cereb Cortex. 2009 Feb;19(2):284-92
references.pmid: 18515298
references.citation: Neuron. 2002 Mar 28;34(1):149-59
references.pmid: 11931749
references.citation: Nat Rev Neurosci. 2003 Feb;4(2):139-47
references.pmid: 12563285
references.citation: Perception. 1983;12(6):719-32
references.pmid: 6678415
references.citation: Neuron. 2002 Aug 1;35(3):575-87
references.pmid: 12165478
references.citation: Curr Opin Neurobiol. 2001 Apr;11(2):231-9
references.pmid: 11301245
references.citation: Nat Neurosci. 2004 Nov;7(11):1190-2
references.pmid: 15475952
references.citation: Neuroimage. 2010 May 1;50(4):1536-44
references.pmid: 20109561
references.citation: J Neurosci. 2007 Apr 18;27(16):4452-9
references.pmid: 17442830
references.citation: J Neurosci. 2007 Oct 17;27(42):11431-41
references.pmid: 17942738
references.citation: Neuroimage. 2006 May 15;31(1):294-300
references.pmid: 16473022
references.citation: Neuroimage. 2002 Jan;15(1):83-97
references.pmid: 11771976
references.citation: Neuron. 2002 Dec 19;36(6):1195-210
references.pmid: 12495632
references.citation: Curr Opin Neurobiol. 2005 Apr;15(2):145-53
references.pmid: 15831395
references.citation: J Neurosci. 2007 Feb 21;27(8):1824-35
references.pmid: 17314280
references.citation: Annu Rev Psychol. 2001;52:337-67
references.pmid: 11148309
references.citation: J Neurosci. 2007 Jan 10;27(2):315-21
references.pmid: 17215392
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14222-7
references.pmid: 18768785
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11702-5
references.pmid: 14500906
references.citation: J Neurophysiol. 1996 Sep;76(3):2071-6
references.pmid: 8890315
references.citation: Nature. 2005 Mar 10;434(7030):158
references.pmid: 15758989
references.citation: Neuroimage. 2002 Sep;17(1):184-200
references.pmid: 12482076
references.citation: Perception. 1981;10(3):331-8
references.pmid: 7329755
references.citation: Nat Neurosci. 2006 Apr;9(4):569-77
references.pmid: 16547508
references.citation: Neuroscientist. 2006 Aug;12(4):327-38
references.pmid: 16840709
references.citation: Int J Psychophysiol. 2000 Mar;35(2-3):125-42
references.pmid: 10677642
references.citation: Neurosci Res. 2006 Apr;54(4):276-80
references.pmid: 16427714
references.citation: Nat Neurosci. 1999 Apr;2(4):382-7
references.pmid: 10204547
references.citation: J Exp Child Psychol. 1992 Apr;53(2):180-99
references.pmid: 1578197
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10722-7
references.pmid: 12960368
references.citation: Brain Res Cogn Brain Res. 1996 Dec;5(1-2):55-67
references.pmid: 9049071
references.citation: Nat Rev Neurosci. 2006 May;7(5):367-79
references.pmid: 16760917
references.citation: Curr Opin Neurol. 2004 Feb;17(1):17-25
references.pmid: 15090873
references.citation: Nat Neurosci. 2003 Feb;6(2):196-202
references.pmid: 12536208
references.citation: Cereb Cortex. 2005 Jun;15(6):870-6
references.pmid: 15459080
references.citation: J Neurosci. 2006 Dec 20;26(51):13128-42
references.pmid: 17182764
references.citation: Dev Sci. 2006 Sep;9(5):454-64
references.pmid: 16911447
references.citation: Nat Rev Neurosci. 2008 Apr;9(4):255-66
references.pmid: 18354398
references.citation: Nat Rev Neurosci. 2000 Oct;1(1):59-65
references.pmid: 11252769
references.citation: Int J Psychophysiol. 2003 Oct;50(1-2):19-26
references.pmid: 14511833
references.citation: J Cogn Neurosci. 1999 Sep;11(5):473-90
references.pmid: 10511637
references.citation: Brain Res Cogn Brain Res. 2002 Jun;14(1):41-63
references.pmid: 12063129
references.citation: J Neurophysiol. 2007 Jul;98(1):545-9
references.pmid: 17475717
references.citation: Nat Rev Neurosci. 2000 Nov;1(2):91-100
references.pmid: 11252779
references.citation: Cereb Cortex. 2001 Dec;11(12):1110-23
references.pmid: 11709482
references.citation: PLoS One. 2008;3(12):e3912
references.pmid: 19066629