title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.
abstract: The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in combinatorial transcriptional control with the AP-1 transcription factor. FOXK2 binding regions are widespread throughout the genome and are often coassociated with AP-1 binding motifs. FOXK2 acts to promote AP-1-dependent gene expression changes in response to activation of the AP-1 pathway. In this context, FOXK2 is required for the efficient recruitment of AP-1 to chromatin. Thus, we have uncovered an important new molecular mechanism that controls AP-1-dependent gene expression.
authors.affiliation: University of Manchester, Manchester, United Kingdom.
authors.forename: Zongling
authors.initials: Z
authors.lastname: Ji
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Donaldson
authors.forename: Jingru
authors.initials: J
authors.lastname: Liu
authors.forename: Andrew
authors.initials: A
authors.lastname: Hayes
authors.forename: Leo A H
authors.initials: LA
authors.lastname: Zeef
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Sharrocks
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015894:Genome, Human; D006801:Humans; D011485:Protein Binding; D034741:RNA, Small Interfering / Q000235:genetics; D018808:Transcription Factor AP-1 / Q000235:genetics* / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D051858:Forkhead Transcription Factors; D034741:RNA, Small Interfering; D018808:Transcription Factor AP-1; C070635:interleukin binding factor
references.citation: Endocrinology. 2009 Nov;150(11):5085-93
references.pmid: 19797124
references.citation: Nucleic Acids Res. 2009 Dec;37(22):7498-508
references.pmid: 19822575
references.citation: J Biol Chem. 2003 Feb 7;278(6):4015-20
references.pmid: 12446708
references.citation: Nature. 2007 Jun 14;447(7146):799-816
references.pmid: 17571346
references.citation: Mol Cell. 2008 Mar 28;29(6):780-5
references.pmid: 18374651
references.citation: Bioinformatics. 2009 Oct 1;25(19):2605-6
references.pmid: 19689956
references.citation: Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7739-43
references.pmid: 1909027
references.citation: FASEB J. 2010 Feb;24(2):346-56
references.pmid: 19762556
references.citation: Nat Rev Genet. 2009 Apr;10(4):233-40
references.pmid: 19274050
references.citation: Stat Appl Genet Mol Biol. 2004;3:Article3
references.pmid: 16646809
references.citation: Nat Methods. 2008 Sep;5(9):829-34
references.pmid: 19160518
references.citation: Mol Cell. 2009 Nov 25;36(4):667-81
references.pmid: 19941826
references.citation: Genome Res. 2009 Mar;19(3):372-80
references.pmid: 19129543
references.citation: Immunity. 1995 May;2(5):461-72
references.pmid: 7749981
references.citation: Cell. 2008 Mar 21;132(6):958-70
references.pmid: 18358809
references.citation: Nat Protoc. 2009;4(1):44-57
references.pmid: 19131956
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D52-7
references.pmid: 21115458
references.citation: J Biochem. 2010 May;147(5):705-9
references.pmid: 20097901
references.citation: Genome Biol. 2009;10(11):R129
references.pmid: 19919681
references.citation: Nat Genet. 2011 Jan;43(1):27-33
references.pmid: 21151129
references.citation: J Cell Sci. 2004 Dec 1;117(Pt 25):5965-73
references.pmid: 15564374
references.citation: Genome Biol. 2010;11(8):R86
references.pmid: 20738864
references.citation: Nucleic Acids Res. 2004 Nov 01;32(19):e151
references.pmid: 15520460
references.citation: J Virol. 2010 Mar;84(6):2719-31
references.pmid: 20053746
references.citation: J Cell Biol. 2008 Dec 15;183(6):1049-60
references.pmid: 19075113
references.citation: J Biol Chem. 1997 Mar 21;272(12):7736-45
references.pmid: 9065434
references.citation: Biochem J. 2000 Jan 15;345 Pt 2:335-43
references.pmid: 10620510
references.citation: Genome Biol. 2008;9(9):R137
references.pmid: 18798982
references.citation: Dev Biol. 2002 Oct 1;250(1):1-23
references.pmid: 12297093
references.citation: J Cell Biol. 2009 May 4;185(3):439-57
references.pmid: 19398761
references.citation: Nucleic Acids Res. 2010 Sep;38(17):5735-45
references.pmid: 20460455
references.citation: Cell. 2005 Jul 15;122(1):33-43
references.pmid: 16009131
references.citation: Genome Res. 2007 Jun;17(6):877-85
references.pmid: 17179217
references.citation: Genome Res. 2009 Nov;19(11):1963-73
references.pmid: 19687146
references.citation: Nucleic Acids Res. 2007 Jul;35(Web Server issue):W253-8
references.pmid: 17478497
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6
references.pmid: 11134512
references.citation: EMBO J. 1994 Oct 17;13(20):5002-12
references.pmid: 7957066
references.citation: Nat Genet. 2010 Mar;42(3):255-9
references.pmid: 20118932
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
references.pmid: 12883005
references.citation: J Biol Chem. 2010 Nov 12;285(46):35728-39
references.pmid: 20810654
references.citation: Bioinformatics. 2003 Jan 22;19(2):185-93
references.pmid: 12538238
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12457-62
references.pmid: 16895995
references.citation: PLoS Genet. 2009 Dec;5(12):e1000778
references.pmid: 20019798
references.citation: Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W199-203
references.pmid: 15215380
references.citation: Nucleic Acids Res. 2007;35(15):5203-12
references.pmid: 17670796
references.citation: Proc Natl Acad Sci U S A. 2000 May 9;97(10):5416-21
references.pmid: 10792059