title: Genome-wide crossover distribution in Arabidopsis thaliana meiosis reveals sex-specific patterns along chromosomes.
abstract: In most species, crossovers (COs) are essential for the accurate segregation of homologous chromosomes at the first meiotic division. Their number and location are tightly regulated. Here, we report a detailed, genome-wide characterization of the rate and localization of COs in Arabidopsis thaliana, in male and female meiosis. We observed dramatic differences between male and female meiosis which included: (i) genetic map length; 575 cM versus 332 cM respectively; (ii) CO distribution patterns: male CO rates were very high at both ends of each chromosome, whereas female CO rates were very low; (iii) correlations between CO rates and various chromosome features: female CO rates correlated strongly and negatively with GC content and gene density but positively with transposable elements (TEs) density, whereas male CO rates correlated positively with the CpG ratio. However, except for CpG, the correlations could be explained by the unequal repartition of these sequences along the Arabidopsis chromosome. For both male and female meiosis, the number of COs per chromosome correlates with chromosome size expressed either in base pairs or as synaptonemal complex length. Finally, we show that interference modulates the CO distribution both in male and female meiosis.
authors.affiliation: Institut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, INRA Centre de Versailles-Grignon, Versailles, France.
authors.forename: Laurène
authors.initials: L
authors.lastname: Giraut
authors.forename: Matthieu
authors.initials: M
authors.lastname: Falque
authors.forename: Jan
authors.initials: J
authors.lastname: Drouaud
authors.forename: Lucie
authors.initials: L
authors.lastname: Pereira
authors.forename: Olivier C
authors.initials: OC
authors.lastname: Martin
authors.forename: Christine
authors.initials: C
authors.lastname: Mézard
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D001482:Base Composition / Q000235:genetics; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics*; D018899:CpG Islands / Q000235:genetics; D003434:Crossing Over, Genetic; D004251:DNA Transposable Elements / Q000235:genetics; D017343:Genes, Plant; D018745:Genome, Plant; D008540:Meiosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic
chemical_list: D004251:DNA Transposable Elements
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