title: A β-resorcylic macrolide from the seagrass-derived fungus Fusarium sp. PSU-ES73.
abstract: A new β-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known β-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.
authors.affiliation: Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Arunpanichlert
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Yaowapa
authors.initials: Y
authors.lastname: Sukpondma
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.forename: Orathai
authors.initials: O
authors.lastname: Supaphon
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D035961:Alismatales / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003455:Cryptococcus neoformans / Q000187:drug effects; D005285:Fermentation; D005670:Fusarium / Q000737:chemistry*; D007202:Indicators and Reagents; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D015025:Zearalenone / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007202:Indicators and Reagents; D018942:Macrolides; D015025:Zearalenone