title: Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.
abstract: CONCLUSIONS
  Association between ten single-nucleotide polymorphisms (SNPs) in the human ALOX12 and ALOX15 genes and variations in peak bone mineral density (BMD) in a large sample of Chinese nuclear families with female offspring using the quantitative transmission disequilibrium test (QTDT). Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.
  
  
  BACKGROUND
  The aim of this study was to investigate whether polymorphisms in the human ALOX12 and ALOX15 genes are associated with variations in peak BMD in Chinese nuclear families with female offspring.
  
  
  METHODS
  Each five SNPs in the ALOX12 and ALOX15 genes were genotyped in a total of 1,260 individuals from 401 Chinese nuclear families. The BMD of the lumbar spine, femoral neck and total hip was measured by dual-energy X-ray absorptiometry. We tested whether a single SNP or a haplotype was associated with peak BMD variations using the QTDT.
  
  
  RESULTS
  Using QTDT to measure within-family associations in ALOX15, we observed a significant association between rs916055 and BMD in the lumbar spine (p = 0.027 in the permutation 1,000 test). However, in ALOX12, rs312470 was significantly associated with BMD in the femoral neck (p = 0.029 and p = 0.036 in the permutation 1,000 test). The results of a haplotype analysis supported the findings of the single locus test for ALOX15.
  
  
  CONCLUSIONS
  Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.
authors.affiliation: Metabolic Bone Disease and Genetics Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, China.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Xiao
authors.forename: Y-H
authors.initials: YH
authors.lastname: Ke
authors.forename: J-W
authors.initials: JW
authors.lastname: He
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: J-B
authors.initials: JB
authors.lastname: Yu
authors.forename: W-W
authors.initials: WW
authors.lastname: Hu
authors.forename: J-M
authors.initials: JM
authors.lastname: Gu
authors.forename: G
authors.initials: G
authors.lastname: Gao
authors.forename: H
authors.initials: H
authors.lastname: Yue
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Hu
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Liu
authors.forename: W-Z
authors.initials: WZ
authors.lastname: Fu
authors.forename: Z-L
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001092:Arachidonate 12-Lipoxygenase / Q000235:genetics*; D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005272:Femur Neck / Q000502:physiology; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006621:Hip Joint / Q000502:physiology; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D001092:Arachidonate 12-Lipoxygenase; C476558:ALOX12 protein, human; C515716:ALOX15 protein, human; D001093:Arachidonate 15-Lipoxygenase
references.citation: J Bone Miner Metab. 2011 Sep;29(5):571-81
references.pmid: 21221677
references.citation: J Bone Miner Res. 2007 Feb;22(2):173-183
references.pmid: 17228994
references.citation: Nucleic Acids Res. 1999 Apr 15;27(8):1828-36
references.pmid: 10101190
references.citation: Calcif Tissue Int. 2007 Jul;81(1):10-7
references.pmid: 17520163
references.citation: Hum Mol Genet. 2010 Feb 15;19(4):720-30
references.pmid: 19942621
references.citation: J Biol Chem. 2011 Apr 8;286(14):12328-39
references.pmid: 21324897
references.citation: J Bone Miner Metab. 2006;24(3):226-34
references.pmid: 16622736
references.citation: Osteoporos Int. 2005 Dec;16(12):1849-56
references.pmid: 15997421
references.citation: Am J Pathol. 2004 May;164(5):1655-62
references.pmid: 15111312
references.citation: J Clin Invest. 2009 Dec;119(12):3666-77
references.pmid: 19920351
references.citation: J Bone Miner Res. 2003 Jun;18(6):1028-35
references.pmid: 12817755
references.citation: Biochim Biophys Acta. 1997 Jun 26;1352(3):267-81
references.pmid: 9224951
references.citation: Genet Epidemiol. 2000 Jul;19(1):18-29
references.pmid: 10861894
references.citation: Proc Natl Acad Sci U S A. 1990 Mar;87(6):2142-6
references.pmid: 2315307
references.citation: J Bone Miner Res. 2006 Nov;21(11):1678-95
references.pmid: 17002564
references.citation: Theor Appl Genet. 1985 Sep;70(6):650-4
references.pmid: 24253123
references.citation: Annu Rev Nutr. 2005;25:317-40
references.pmid: 16011470
references.citation: J Bone Miner Metab. 2005;23(3):226-30
references.pmid: 15838625
references.citation: J Clin Endocrinol Metab. 2006 Sep;91(9):3349-54
references.pmid: 16608888
references.citation: Osteoporos Int. 2011 Aug;22(8):2249-59
references.pmid: 21104233
references.citation: Hum Hered. 2008;65(1):1-8
references.pmid: 17652958
references.citation: J Clin Invest. 2004 Mar;113(6):846-55
references.pmid: 15067317
references.citation: Eur J Hum Genet. 2000 Jul;8(7):545-51
references.pmid: 10909856
references.citation: Am J Hum Genet. 2001 Apr;68(4):978-89
references.pmid: 11254454
references.citation: Osteoporos Int. 2008 Jan;19(1):39-47
references.pmid: 17703271
references.citation: J Bone Miner Metab. 2005;23(4):275-9
references.pmid: 15981022
references.citation: Acta Pharmacol Sin. 2004 Apr;25(4):462-8
references.pmid: 15066214
references.citation: J Biol Chem. 1994 May 13;269(19):13979-87
references.pmid: 8188678
references.citation: Int J Obes (Lond). 2011 Mar;35(3):378-86
references.pmid: 20697415
references.citation: Science. 2004 Jan 9;303(5655):229-32
references.pmid: 14716014
references.citation: Bioinformatics. 2005 Jan 15;21(2):263-5
references.pmid: 15297300
references.citation: FEBS Lett. 2008 Sep 22;582(21-22):3249-53
references.pmid: 18755188
references.citation: Osteoporos Int. 2004 Jun;15(6):489-96
references.pmid: 15205721
references.citation: Nature. 1999 Jul 22;400(6742):378-82
references.pmid: 10432118
references.citation: Eur J Hum Genet. 1998 Mar-Apr;6(2):151-7
references.pmid: 9781060
references.citation: Acta Pharmacol Sin. 2007 Feb;28(2):287-95
references.pmid: 17241533
references.citation: Osteoporos Int. 2010 May;21(5):873-82
references.pmid: 19644638
references.citation: J Bone Miner Res. 2006 Apr;21(4):556-64
references.pmid: 16598376
references.citation: BMC Med Genet. 2010 Jan 01;11:1
references.pmid: 20043861