title: ARID2: a new tumor suppressor gene in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.
authors.affiliation: Department of abdominal surgical oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Han
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Jianming
authors.initials: J
authors.lastname: Ying
authors.forename: Xinyu
authors.initials: X
authors.lastname: Bi
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhou
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.forename: Yefan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.forename: Linfang
authors.initials: L
authors.lastname: Wang
authors.forename: Michael S
authors.initials: MS
authors.lastname: Torbenson
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C512511:ARID2 protein, human; D014157:Transcription Factors
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