title: Economic burden of Pseudomonas aeruginosa infection in patients with cystic fibrosis.
abstract: OBJECTIVE
  Chronic infection with Pseudomonas aeruginosa (PA) is the primary cause of pulmonary deterioration in cystic fibrosis (CF). This study describes healthcare costs and resource utilization among CF patients following PA infection in the US.
  
  
  METHODS
  This retrospective study utilized data from MarketScan claims database. CF patients with an initial PA infection were identified, and their healthcare utilization, medical and pharmacy costs were extracted for 12 months, pre- and post-PA infection. Descriptive and pair-wise non-parametric statistical analyses compared healthcare utilization and costs before and after infection.
  
  
  RESULTS
  Three hundred and fifty-eight CF patients met study criteria (mean age 20.1 years; 48% female). Mean annual per-patient costs following initial PA infection increased by an estimated $18,516 (outpatient: $3113; inpatient: $10,123; pharmacy: $4943). Overall healthcare costs were significantly higher (p < 0.0001) following PA infection, as were overall inpatient visits, outpatient visits, and unique prescriptions (p < 0.0001).
  
  
  CONCLUSIONS
  PA infection in cystic fibrosis creates a significant economic burden and the cost is not uniformly distributed across the healthcare components.
  
  
  CONCLUSIONS
  Key limitations of this study include the absence of clinical parameters to characterize PA infections and data on indirect costs such as loss of productivity or caretaker-related burden.
authors.affiliation: College of Pharmacy, University of Houston , Houston, TX 77030, USA. ssansgiry@uh.edu
authors.forename: Sujit S
authors.initials: SS
authors.lastname: Sansgiry
authors.forename: Vijay N
authors.initials: VN
authors.lastname: Joish
authors.forename: Susan
authors.initials: S
authors.lastname: Boklage
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Goyal
authors.forename: Pooja
authors.initials: P
authors.lastname: Chopra
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sethi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications*; D016208:Databases, Factual; D005260:Female; D005102:Health Expenditures / Q000639:trends*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000150:complications / Q000191:economics*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012189:Retrospective Studies; D055815:Young Adult