title: Glycyrrhetinic acid protects mice from Staphylococcus aureus pneumonia.
abstract: In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system.
authors.affiliation: Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, PR China.
authors.forename: Hong-en
authors.initials: HE
authors.lastname: Li
authors.forename: Jia-zhang
authors.initials: JZ
authors.lastname: Qiu
authors.forename: Zhan-qing
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Ming-jing
authors.initials: MJ
authors.lastname: Luo
authors.forename: Juan
authors.initials: J
authors.lastname: Pan
authors.forename: Xiao-han
authors.initials: XH
authors.lastname: Dai
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bai-lin
authors.initials: BL
authors.lastname: Song
authors.forename: Xu-ming
authors.initials: XM
authors.lastname: Deng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018410:Pneumonia, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000517:prevention & control*; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D006034:Glycyrrhetinic Acid