title: Development of hydrophilic photolabile hydroxyl protecting groups.
abstract: Hydrophilic photolabile protecting groups (PPGs) for hydroxyl protection have been developed. The new PPGs are derived from 3-(dimethylamino)trityl (DMATr) by replacing the two methyl groups with two hydrophilic butyryl groups. The new PPG reagents can be readily prepared and installed. They are stable in the dark but can be removed cleanly and efficiently in aqueous environments upon irradiation with a UV lamp or sunlight.
authors.affiliation: Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States. wangp@uab.edu
authors.forename: Haishen
authors.initials: H
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang