title: Uric acid level and its association with carotid intima-media thickness in patients with cardiac syndrome X.
abstract: OBJECTIVE
  The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX).
  
  
  METHODS
  A total of 50 patients with CSX (28 females/22 males, 51.0 ± 10.9 years) and 40 controls (27 females/13 males, 53.0 ± 10.2 years) were included in the study. All subjects underwent a noninvasive stress test and conventional coronary angiography. Serum uric acid levels were measured and B mode ultrasonography was performed to assess CIMT in all subjects.
  
  
  RESULTS
  Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 ± 1.8 vs. 3.9 ± 1.3 mg/dl; p = 0.002). The CIMT was higher in patients with CSX than in the control subjects (0.75 ± 0.18 vs. 0.63 ± 0.09 mm; p < 0.001). A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001).
  
  
  CONCLUSIONS
  Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients.
authors.affiliation: Department of Cardiology, College of Medicine, Inonu University, Malatya, Turkey. nusretacikgoz@hotmail.com
authors.forename: Nusret
authors.initials: N
authors.lastname: Acikgoz
authors.forename: Necip
authors.initials: N
authors.lastname: Ermis
authors.forename: Julide
authors.initials: J
authors.lastname: Yagmur
authors.forename: Kubra
authors.initials: K
authors.lastname: Muezzinoglu
authors.forename: Yasin
authors.initials: Y
authors.lastname: Karakus
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cansel
authors.forename: Hasan
authors.initials: H
authors.lastname: Pekdemir
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000097:blood* / Q000000981:diagnostic imaging; D008875:Middle Aged; D011859:Radiography; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid