title: Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia.
abstract: OBJECTIVE
  Many patients with benign prostatic hyperplasia (BPH) have storage symptoms. The aim of this study was to evaluate the effects of treatment with a 5-alpha reductase inhibitor (5ARI) on storage symptoms in patients with BPH.
  
  
  METHODS
  This study was conducted in 738 patients with lower urinary tract symptoms secondary to BPH. Patients with a prostate volume of higher than 30 mL on the transrectal ultrasound were classified into two groups: group A, in which an alpha blocker was solely administered for at least 12 months, and group B, in which a combination treatment regimen of an alpha blocker plus 5ARI was used. This was followed by an analysis of the changes in parameters such as the total International Prostate Symptom Score (IPSS), voiding symptom subscore, and storage symptom subscore between the two groups. In addition, we examined whether there was a significant difference between the two groups in the degree of change in storage symptoms between before and after the pharmacological treatment.
  
  
  RESULTS
  Of the 738 men, 331 had a prostate volume ≥30 mL, including 150 patients in group A and 181 patients in group B. Total IPSS, the voiding symptom subscore, and the storage symptom subscore were significantly lower after treatment than before treatment in both groups (P<0.05). A comparison of the degree of change between before and after treatment, however, showed no significant differences in the storage symptom subscore between the two groups (P>0.05).
  
  
  CONCLUSIONS
  Alpha blocker and 5ARI combination treatment is effective for patients with BPH including storage symptoms. However, 5ARI does not exert a significant effect on storage symptoms in BPH patients.
authors.affiliation: Department of Urology, The Catholic University of Korea School of Medicine, Seoul, Korea.
authors.forename: Kang Jun
authors.initials: KJ
authors.lastname: Cho
authors.forename: Se Hee
authors.initials: SH
authors.lastname: Kang
authors.forename: Hyo Sin
authors.initials: HS
authors.lastname: Kim
authors.forename: Jun Sung
authors.initials: JS
authors.lastname: Koh
authors.forename: Joon Chul
authors.initials: JC
authors.lastname: Kim
references.citation: Prostate. 2001 Jan 1;46(1):45-51
references.pmid: 11170131
references.citation: J Urol. 1992 Nov;148(5):1467-74
references.pmid: 1279214
references.citation: Korean J Urol. 2011 Apr;52(4):274-8
references.pmid: 21556215
references.citation: Urology. 2003 Sep;62(3 Suppl 1):6-14
references.pmid: 12957195
references.citation: BJU Int. 2004 Sep;94(5):738-44
references.pmid: 15329091
references.citation: Chin Med J (Engl). 2007 Mar 5;120(5):370-4
references.pmid: 17376305
references.citation: J Urol. 1998 Sep;160(3 Pt 1):937-43
references.pmid: 9720591
references.citation: Eur Urol. 2006 Dec;50(6):1306-14; discussion 1314-5
references.pmid: 17049716
references.citation: Yonsei Med J. 2010 Mar;51(2):248-52
references.pmid: 20191018
references.citation: Scand J Urol Nephrol. 2003;37(4):322-8
references.pmid: 12944191
references.citation: J Androl. 1991 Nov-Dec;12(6):356-63
references.pmid: 1722791
references.citation: J Urol. 2003 Aug;170(2 Pt 1):530-47
references.pmid: 12853821
references.citation: BJU Int. 2011 May;107(9):1426-31
references.pmid: 21348912
references.citation: Eur Urol. 2004 Oct;46(4):488-94; discussion 495
references.pmid: 15363566
references.citation: World J Urol. 2010 Oct;28(5):609-14
references.pmid: 19834713
references.citation: Neurourol Urodyn. 2010 Apr;29(4):558-62
references.pmid: 19693954
references.citation: Prostate Cancer Prostatic Dis. 2009;12(4):369-74
references.pmid: 19901936
references.citation: Urology. 2011 Jan;77(1):171-6
references.pmid: 20691464
references.citation: Eur Urol. 2004 Nov;46(5):547-54
references.pmid: 15474261
references.citation: Eur Urol. 2007 Jan;51(1):57-66
references.pmid: 16979287
references.citation: Int J Urol. 2006 Jan;13(1):15-20
references.pmid: 16448426
references.citation: Rev Urol. 2008 Winter;10(1):14-25
references.pmid: 18470272