title: Flow sensing of single cell by graphene transistor in a microfluidic channel.
abstract: The electronic properties of graphene are strongly influenced by electrostatic forces arising from long-range charge scatterers and by changes in the local dielectric environment. This makes graphene extremely sensitive to the surface charge density of cells interfacing with it. Here, we developed a graphene transistor array integrated with microfluidic flow cytometry for the "flow-catch-release" sensing of malaria-infected red blood cells at the single-cell level. Malaria-infected red blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene. Together with the characteristic conductance dwell times, specific microscopic information about the disease state can be obtained.
authors.affiliation: Graphene Research Centre, Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Priscilla Kailian
authors.initials: PK
authors.lastname: Ang
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Manu
authors.initials: M
authors.lastname: Jaiswal
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Han Wei
authors.initials: HW
authors.lastname: Hou
authors.forename: John T L
authors.initials: JT
authors.lastname: Thong
authors.forename: Chwee Teck
authors.initials: CT
authors.lastname: Lim
authors.forename: Kian Ping
authors.initials: KP
authors.lastname: Loh