title: Sleep quality and asthma control and quality of life in non-severe and severe asthma.
abstract: OBJECTIVE
  The effect of sleep quality on asthma control independent from common comorbidities like gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA) is unknown. This study examined the association between sleep quality and asthma control and quality of life after accounting for OSA and GERD in non-severe (NSA) and severe (SA) asthma.
  
  
  METHODS
  Cross-sectional data from 60 normal controls, 143 with NSA, and 79 with SA participating in the Severe Asthma Research Program was examined. Those who reported using positive airway pressure therapy or were at high risk for OSA were excluded.
  
  
  RESULTS
  Both SA and NSA had poorer sleep quality than controls, with SA reporting the worst sleep quality. All asthmatics with GERD and 92% of those without GERD had poor sleep quality (p = 0.02). The majority (88-100%) of NSA and SA participants who did not report nighttime asthma disturbances still reported having poor sleep quality. In both NSA and SA, poor sleep quality was associated with worse asthma control and quality of life after controlling for GERD and other covariates.
  
  
  CONCLUSIONS
  These results suggest that poor sleep quality is associated with poor asthma control and quality of life among asthmatics and cannot be explained by comorbid GERD and nighttime asthma disturbances.
authors.affiliation: University of Pittsburgh School of Nursing, Pittsburgh, PA, USA. luysterfs@upmc.edu
authors.forename: Faith S
authors.initials: FS
authors.lastname: Luyster
authors.forename: Mihaela
authors.initials: M
authors.lastname: Teodorescu
authors.forename: Eugene
authors.initials: E
authors.lastname: Bleecker
authors.forename: William
authors.initials: W
authors.lastname: Busse
authors.forename: William
authors.initials: W
authors.lastname: Calhoun
authors.forename: Mario
authors.initials: M
authors.lastname: Castro
authors.forename: Kian Fan
authors.initials: KF
authors.lastname: Chung
authors.forename: Serpil
authors.initials: S
authors.lastname: Erzurum
authors.forename: Elliot
authors.initials: E
authors.lastname: Israel
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Strollo
authors.forename: Sally E
authors.initials: SE
authors.lastname: Wenzel
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001249:Asthma / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D015331:Cohort Studies; D015897:Comorbidity; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011788:Quality of Life; D012189:Retrospective Studies; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
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