title: Acute Respiratory Distress Syndrome as a presenting manifestation in young patients infected with H1N1 influenza virus.
abstract: BACKGROUND
  The new strain of influenza A (H1N1) 2009, often referred to colloquially as "swine flu", which was first detected in April 2009, raised to a pandemic of which the impact was not completely predictable. As reported, numerous cases with severe respiratory failure were also seen among young previously healthy people.
  
  
  METHODS
  In the present study, we report eight cases of influenza A (H1N1) 2009 admitted to our medical intensive care with severe respiratory failure between November and December 2009 and in January 2011. All patients were older than 30 but younger than 50 years, had clinical and radiological evidence of an Acute Respiratory Distress Syndrome (ARDS) and needed invasive ventilatory support.
  
  
  RESULTS
  Six of the eight patients had no relevant underlying disease; one had a pre-existing idiopathic lung fibrosis and another had a chronic obstructive pulmonary disease (COPD), an abuse of alcohol and an adiposities grade 3. Four patients needed an extracorporeal membrane oxygenation (ECMO) due to severe respiratory failure with global respiratory insufficiency that could not be treated by conservative ventilatory support. The one patient with a pre-existing lung fibrosis died shortly after lung transplantation despite use of an extracorporeal membrane oxygenation. One other patient died due to a subarachnoidal bleeding under the anticoagulatory regime during ECMO therapy. The adipose COPD-patient died due to septic shock with multiple organ failure without possibility for ECMO support.
  
  
  CONCLUSIONS
  The clinical course of severe cases of influenza A (H1N1) 2009-infection is markedly different from the disease pattern seen during epidemics of seasonal influenza. Most of the patients admitted to our intensive care unit due to influenza A (H1N1) 2009 associated ARDS were previously healthy young people.
authors.affiliation: Department of Medicine D, Nephrology and Rheumatology, University Hospital of Muenster, Germany. dirk.pabst@ukmuenster.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Pabst
authors.forename: Joachim
authors.initials: J
authors.lastname: Kuehn
authors.forename: Susanne
authors.initials: S
authors.lastname: Schuler-Luettmann
authors.forename: Karsten
authors.initials: K
authors.lastname: Wiebe
authors.forename: Pia
authors.initials: P
authors.lastname: Lebiedz
mesh_terms: D000328:Adult; D004632:Emergency Medical Services; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000628:therapy* / Q000821:virology*; D014057:Tomography, X-Ray Computed