title: Syncope and autonomic cardiovascular dysfunction in Parkinson disease.
abstract: OBJECTIVE
  The aim of the study was to investigate the relationship between syncope or presyncope occurrence and dysfunction of the cardiovascular autonomic system in patients with Parkinson disease (PD).
  
  
  METHODS
  Twenty-four PD patients were studied, including 10 subjects with syncope/presyncope and 14 con-trols without those symptoms. Ambulatory blood pressure monitoring (ABPM), Holter electrocardiographic monitoring, carotid sinus massage, tilt test, and cardiac scintigraphy with 123I metaiodobenzylguanidine (MIBG) were performed.
  
  
  RESULTS
  Differences between the two groups were found in myocardial scintigraphy and ABPM. The stepwise regression analyses suggest that the values of late phase reduced uptake of MIBG (95% CI: 0.0-0.77; p < 0.05) and day-time minimum systolic blood pressure (95% CI: 0.78-0.98; p = 0.007) may be related to the occurrence of syncope/presyncope.
  
  
  CONCLUSIONS
  The findings suggest an association between syncope/presyncope occurrence and dysfunction of the cardiovascular autonomic system in PD patients. Both 123I MIBG myocardial scintigraphy and ABPM may help identify a group of patients with an elevated risk for syncopic episodes which, in turn, may affect the choice of treatment.
authors.affiliation: Klinika Neurologii i Epileptologii CMKP, ul. Czerniakowska 231, Warszawa. martalenska@wp.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Leńska-Mieciek
authors.forename: Igneborga
authors.initials: I
authors.lastname: Derecka-Charzyńska
authors.forename: Urszula
authors.initials: U
authors.lastname: Fiszer
authors.forename: Leszek
authors.initials: L
authors.lastname: Królicki
authors.forename: Piotr
authors.initials: P
authors.lastname: Kułakowski
mesh_terms: D019797:3-Iodobenzylguanidine; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011044:Poland; D011877:Radionuclide Imaging; D012044:Regression Analysis; D012307:Risk Factors; D013575:Syncope / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology
chemical_list: D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine