title: Polyvalent DNA-graphene nanosheets "click" conjugates.
abstract: Graphene is an increasingly important nanomaterial exhibiting great promise in the area of nanotechnology. In this study, the azide-functionalized graphene derivative was synthesized as the 'click' reagent for preparation of polyvalent DNA-graphene conjugates, which provide an effective and stable platform to construct new functional nano-architectures. Assembled with Au nanoparticles, the prepared Au-DNA-graphene nanocomplex exhibits excellent stability that could prevent the nanocomplex from being destroyed by surfactants. Assembled with DNA tetrahedron-structured probes (TSPs), the nanocomplex displays outstanding sensitive electrochemiluminescence properties, which might be used as a biosensor for DNA detection. Therefore, this DNA-graphene conjugates could be explored as the assembly unit for advanced DNA nano-architectures in the field of DNA nanotechnology.
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Zihao
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Ge
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Zheng
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D003460:Crystallization / Q000379:methods; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D006108:Graphite / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D046911:Macromolecular Substances; D006108:Graphite; D004247:DNA