title: Synthesis of 1,2,3-triazole-fused heterocycles via Pd-catalyzed cyclization of 5-iodotriazoles.
abstract: A convenient approach toward polycyclic frameworks containing fused 1,2,3-triazoles is described. The synthesis consists of a Cu-catalyzed cycloaddition and an intramolecular Pd-catalyzed direct arylation or Heck reaction, and affords the products in good to excellent yields.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada M5S 3H6.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Schulman
authors.forename: Adam A
authors.initials: AA
authors.lastname: Friedman
authors.forename: Jane
authors.initials: J
authors.lastname: Panteleev
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D054879:Halogenation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D014230:Triazoles; D010165:Palladium