title: [DNA sequence-specific ligands: XIV. Synthesis of fluorescent biologicaly active dimeric bisbenzimidazoles-DB(3, 4, 5, 7, 11)].
abstract: Five fluorescent symmetric dimeric bisbenzimidazoles DB(n) have been synthesized containing four 2,6-substited benzimidazole fragments and differ in length of oligomethylene linker (n=3, 4, 5, 7, 11) between the two bisbenzimidazole blocks. The ability of these dimeric bisbenzimidazoles to form complexes with double-stranded DNA (dsDNA) was shown by spectral methods. Upon binding to dsDNA DB(n) are localized in the minor groove. The DNA-methyltransferase Dnmt3a inhibition data are demonstrate the site-specific binding of dimeric bisbenzimidazoles DB(3) and DB(11) with oligonucleotide duplex.
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.forename: V I
authors.initials: VI
authors.lastname: Salianov
authors.forename: S A
authors.initials: SA
authors.lastname: Strel'tsov
authors.forename: N A
authors.initials: NA
authors.lastname: Cherepanova
authors.forename: E S
authors.initials: ES
authors.lastname: Gromova
authors.forename: A L
authors.initials: AL
authors.lastname: Zhuze
mesh_terms: D000818:Animals; D020029:Base Pairing; D001665:Binding Sites; D006690:Bisbenzimidazole / Q000138:chemical synthesis* / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors / Q000737:chemistry; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D004264:DNA Topoisomerases, Type I / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D051379:Mice; D012680:Sensitivity and Specificity
chemical_list: C000715535:Dnmt3a protein, mouse; D005456:Fluorescent Dyes; D008024:Ligands; D004247:DNA; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D004264:DNA Topoisomerases, Type I; D006690:Bisbenzimidazole