title: Antifungal susceptibility profiles of Candida isolates from a prospective survey of invasive fungal infections in Italian intensive care units.
abstract: The antifungal susceptibility pattern of 302 Candida isolates collected during an Italian survey on invasive fungal infections in an intensive care setting was investigated. The results were correlated with some epidemiological data and compared with the antifungal profiles obtained in a previous survey. No resistance to echinocandins was detected. The overall resistance levels to fluconazole, posaconazole and voriconazole were 12.6, 6.0 and 7.1 %, respectively. Candida tropicalis and Candida parapsilosis accounted for more than half of all the fluconazole resistant isolates. Reduced susceptibility to fluconazole is not uncommon among isolates (12.3 %) and appears to be increasing, particularly among C. parapsilosis isolates, which showed an increase in resistant isolates from 2 % in the 1990s to 25.8 % in the present study. Routine antifungal susceptibility testing of this species is therefore recommended.
authors.affiliation: Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, via Pascal 36, 20133 Milano, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Tortorano
authors.affiliation: Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, via Pascal 36, 20133 Milano, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Prigitano
authors.affiliation: Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, via Pascal 36, 20133 Milano, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Dho
authors.affiliation: Laboratorio di Microbiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, via F. Sforza 35, 20122 Milano, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Grancini
authors.affiliation: Laboratorio di Microbiologia, Ospedali Riuniti di Bergamo, largo Barozzi 1, 24128 Bergamo, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Passera
authors.lastname: For The Ecmm-Fimua Study Group
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D007362:Intensive Care Units; D007558:Italy; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents