title: IL1 gene polymorphisms and unsuccessful dental implants.
abstract: OBJECTIVE
  This study aimed to analyse the association between polymorphisms in the IL1 gene cluster and failure of dental implants in a Portuguese population.
  
  
  METHODS
  A total of 155 Caucasian Portuguese subjects were divided into two groups: 100 with successful dental implants and 55 with unsuccessful dental implants. DNA was obtained through an oral mucosa scraping. PCR was used to identify the polymorphisms: single nucleotide changes in positions -889 of IL1A gene and +3953 of IL1B gene.
  
  
  RESULTS
  The prevalence of the polymorphisms -889IL1A gene and +3953IL1B gene, determined by the positive result of TGP (Genetic Test for Periodontitis; CGC, Genetics, Portugal), in the studied population rehabilitated with dental implants was of 33.50%. Allele 1 of the IL1B gene was the most prevalent (62.20%), followed by allele 1 of the IL1A gene (54.80%) and the least frequent was allele 2 of IL1B gene (37.40%). Success of dental implants was mainly associated with a negative TGP result, whereas no success was found to be related to a positive result. There were no statistically significant differences between the alleles 1 and 2 of the genes IL1A and IL1B and the tobacco and alcohol consumption for the success or no success of the dental implants.
  
  
  CONCLUSIONS
  The alleles 1 and 2 of IL1A gene and the alleles 1 and 2 of IL1B gene were statistically associated with the success or no success of the dental implants. Tobacco habit and alcohol consumption showed no statistically significant association with success or no success of the dental implants.
authors.affiliation: Serviço de Genética Médica e Orofacial, Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal. pvaz@fmd.up.pt
authors.forename: P
authors.initials: P
authors.lastname: Vaz
authors.forename: M M
authors.initials: MM
authors.lastname: Gallas
authors.forename: A C
authors.initials: AC
authors.lastname: Braga
authors.forename: J C
authors.initials: JC
authors.lastname: Sampaio-Fernandes
authors.forename: A
authors.initials: A
authors.lastname: Felino
authors.forename: P
authors.initials: P
authors.lastname: Tavares
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D000483:Alleles; D015921:Dental Implants; D019232:Dental Restoration Failure; D005260:Female; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011174:Portugal / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D015921:Dental Implants; D053582:Interleukin-1alpha; D053583:Interleukin-1beta