title: Uncovering the role of 5-hydroxymethylcytosine in the epigenome.
abstract: Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
authors.affiliation: Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK. miguel.branco@babraham.ac.uk
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Branco
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ficz
authors.forename: Wolf
authors.initials: W
authors.lastname: Reik
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism / Q000031:analogs & derivatives; D000818:Animals; D053624:Blastocyst Inner Cell Mass / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D002843:Chromatin / Q000378:metabolism; D018899:CpG Islands / Q000502:physiology; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003641:Deamination / Q000235:genetics; D049308:Dioxygenases; D053595:Embryonic Stem Cells / Q000166:cytology / Q000201:enzymology; D044127:Epigenesis, Genetic / Q000235:genetics*; D057890:Epigenomics / Q000379:methods*; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing / Q000502:physiology; D016678:Genome / Q000235:genetics; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D006899:Mixed Function Oxygenases; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D014018:Tissue Distribution / Q000235:genetics
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C540839:TET1 protein, mouse; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine; D004247:DNA; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human; C551914:Tet2 protein, mouse; C551915:Tet3 protein, mouse
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