title: Somatic mutations in aging, cancer and neurodegeneration.
abstract: The somatic mutation theory of aging posits that the accumulation of mutations in the genetic material of somatic cells as a function of time results in a decrease in cellular function. In particular, the accumulation of random mutations may inactivate genes that are important for the functioning of the somatic cells of various organ systems of the adult, result in a decrease in organ function. When the organ function decreases below a critical level, death occurs. A significant amount of research has shown that somatic mutations play an important role in aging and a number of age related pathologies. In this review, we explore evidence for increases in somatic nuclear mutation burden with age and the consequences for aging, cancer, and neurodegeneration. We then review evidence for increases in mitochondrial mutation burden and the consequences for dysfunction in the disease processes.
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195-7705, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Kennedy
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Loeb
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Herr
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics* / Q000473:pathology; D000818:Animals; D004272:DNA, Mitochondrial; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000473:pathology; D010641:Phenotype
chemical_list: D004272:DNA, Mitochondrial
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