title: Platelet count/bipolar spleen diameter ratio for the prediction of esophageal varices: The special Egyptian situation: Noninvasive prediction of esophageal varices.
abstract: BACKGROUND
  Esophageal variceal hemorrhage is a devastating complication of portal hypertension that occurs in approximately one-third of cirrhotic patients.
  
  
  OBJECTIVE
  We assessed the value of the platelet count/ bipolar spleen diameter ratio as a noninvasive parameter for the prediction of esophageal varices (EVs) in Egyptian cirrhotic patients.
  
  
  METHODS
  Laboratory and ultrasonographic and imaging variables were prospectively evaluated in 175 patients with liver cirrhosis. All patients underwent upper gastrointestinal endoscopy. Patients with active gastrointestinal bleeding at the time of admission were excluded.
  
  
  RESULTS
  The platelet count/ bipolar spleen diameter ratio in patients with EVs was significantly lower than in patients without EVs. In an analysis of the receiver operating characteristic curves (ROCs), we calculated an optimal cutoff value of 939.7 for this ratio, which gave 100% sensitivity and negative predictive values, 86.3% specificity, a 95.6% positive predictive value, and an area under the ROC curve of 0.94 ± 0.02, reflecting its overall diagnostic accuracy. These findings were extended to a subset analysis of compensated cirrhotic patients.
  
  
  CONCLUSIONS
  The platelet count/ bipolar spleen diameter ratio has excellent accuracy in the noninvasive assessment of EVs in patients with compensated or decompensated liver cirrhosis. It is easy to calculate and can lower the financial and sanitary burdens of endoscopy units, especially in developing countries.
authors.affiliation: Department of Internal Medicine, Minia University, Minya, Egypt.
authors.forename: Mona A
authors.initials: MA
authors.lastname: Abu El Makarem
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Shatat
authors.forename: Yehya
authors.initials: Y
authors.lastname: Shaker
authors.forename: Ahmad A
authors.initials: AA
authors.lastname: Abdel Aleem
authors.forename: Ali M
authors.initials: AM
authors.lastname: El Sherif
authors.forename: Maysa Abdel
authors.initials: MA
authors.lastname: Moaty
authors.forename: Hosny S
authors.initials: HS
authors.lastname: Abdel Ghany
authors.forename: Atef
authors.initials: A
authors.lastname: Elakad
authors.forename: Amal M
authors.initials: AM
authors.lastname: Kamal Eldeen
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