title: Prenatal diagnosis in a mentally retarded woman with mosaic ring chromosome 18.
abstract: We present a pregnant woman with mental retardation and mosaic for ring 18 referred for prenatal diagnosis. Major clinical features included short stature with clinodactyly in feet, foot deformity and club feet, hypotonia, kyphosis, and absence of breast development, low set ears, high arched palate, dental decay and speech disorder. Prenatal diagnosis was carried. Using amniocentesis. The fetus had a normal karyotype described as 46,XX. The fetus was evaluated for clinical features after delivery; she was healthy with no abnormal clinical characterizations.
authors.affiliation: Sarem Cell Research Center, Sarem Hospital, Tehran, Iran.
authors.forename: Eiman
authors.initials: E
authors.lastname: Bagherizadeh
authors.forename: Farkhondeh
authors.initials: F
authors.lastname: Behjati
authors.forename: Seyed Hoseinali
authors.initials: SH
authors.lastname: Saberi
authors.forename: Yousef
authors.initials: Y
authors.lastname: Shafeghati
references.citation: J Ment Defic Res. 1970 Mar;14(1):49-67
references.pmid: 5534732
references.citation: Eur J Pediatr. 1994 Feb;153(2):110-2
references.pmid: 8157016
references.citation: Ann Genet. 1964;7:17-23
references.pmid: 14242103
references.citation: J Paediatr Child Health. 1998 Feb;34(1):92-4
references.pmid: 9568951
references.citation: Clin Dysmorphol. 1997 Oct;6(4):351-8
references.pmid: 9354845
references.citation: Am J Med Genet. 1999 Aug 27;85(5):455-62
references.pmid: 10405442
references.citation: Arch Dis Child. 1988 Sep;63(9):1090-1
references.pmid: 3178273
references.citation: J Med Genet. 1993 Nov;30(11):964-5
references.pmid: 8301656
references.citation: J Med Genet. 1999 Feb;36(2):156-8
references.pmid: 10051018
references.citation: Neuropediatrics. 1997 Dec;28(6):335-7
references.pmid: 9453033