title: Two patients walk into a clinic...a genomics perspective on the future of schizophrenia.
abstract: Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental factors. The genetic heterogeneity underlying schizophrenia and the overlap with other neurodevelopmental disorders suggest that it will not continue to be viewed as a single disease. This has radical implications for clinical practice, as diagnosis and treatment will be guided by molecular etiology rather than clinical diagnostic criteria.
authors.affiliation: Department of Psychiatry, Trinity College Dublin, Dublin 2, Ireland. acorvin@tcd.ie
authors.forename: Aiden P
authors.initials: AP
authors.lastname: Corvin
mesh_terms: D001483:Base Sequence; D015894:Genome, Human / Q000235:genetics; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods*; D006801:Humans; D009154:Mutation / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
references.citation: Nature. 2009 Aug 6;460(7256):744-7
references.pmid: 19571808
references.citation: Am J Psychiatry. 2011 Mar;168(3):302-16
references.pmid: 21285140
references.citation: Nat Genet. 2011 Sep 18;43(10):969-76
references.pmid: 21926974
references.citation: Nat Genet. 2010 Nov;42(11):1021-6
references.pmid: 20890276
references.citation: Lancet. 2009 Jan 17;373(9659):234-9
references.pmid: 19150704
references.citation: Nat Rev Neurosci. 2010 Jun;11(6):402-16
references.pmid: 20485365
references.citation: Schizophr Bull. 2011 Jan;37(1):14-20
references.pmid: 21149852
references.citation: Nat Neurosci. 2010 Oct;13(10):1161-9
references.pmid: 20877280
references.citation: Lancet. 2010 Oct 23;376(9750):1366-7
references.pmid: 20971347
references.citation: PLoS Genet. 2011 Feb;7(2):e1001318
references.pmid: 21383861
references.citation: Lancet. 2009 Aug 22;374(9690):620-7
references.pmid: 19595447
references.citation: Nature. 2011 Mar 24;471(7339):499-503
references.pmid: 21346763
references.citation: Nature. 2008 Sep 11;455(7210):237-41
references.pmid: 18668038
references.citation: Lancet. 1990 Jul 7;336(8706):13-6
references.pmid: 1973210
references.citation: Mol Psychiatry. 2011 Jan;16(1):17-25
references.pmid: 19786961
references.citation: Hum Mol Genet. 2011 Oct 15;20(20):4076-81
references.pmid: 21791550
references.citation: Hum Mol Genet. 2009 Apr 15;18(8):1497-503
references.pmid: 19181681
references.citation: Am J Hum Genet. 2010 Sep 10;87(3):316-24
references.pmid: 20797689
references.citation: Neuron. 2010 Oct 21;68(2):245-53
references.pmid: 20955932
references.citation: Science. 2008 Apr 25;320(5875):539-43
references.pmid: 18369103
references.citation: Science. 2010 Mar 26;327(5973):1580-1
references.pmid: 20339051
references.citation: Hum Mol Genet. 2009 Mar 1;18(5):988-96
references.pmid: 18945720
references.citation: Nature. 2009 Aug 6;460(7256):748-52
references.pmid: 19571811
references.citation: Nature. 2009 Aug 6;460(7256):753-7
references.pmid: 19571809
references.citation: Nature. 2010 Oct 14;467(7317):832-8
references.pmid: 20881960
references.citation: Nat Rev Genet. 2008 May;9(5):356-69
references.pmid: 18398418
references.citation: Nat Genet. 2008 Sep;40(9):1053-5
references.pmid: 18677311
references.citation: Hum Mol Genet. 2010 Sep 1;19(17):3477-81
references.pmid: 20587603
references.citation: Nature. 2008 Sep 11;455(7210):232-6
references.pmid: 18668039
references.citation: Nature. 2011 May 12;473(7346):221-5
references.pmid: 21490598
references.citation: Nature. 2011 Sep 11;478(7367):103-9
references.pmid: 21909115