title: Dyslipidemia and pediatric obesity.
abstract: Cardiovascular disease is the leading cause of death in the United States despite a reduction in mortality over the past 4 decades. Much of this success is attributed to public health efforts and more aggressive treatment of clinical disease. The rising rates of obesity and diabetes, especially among adolescents and young adults, raise concern for increases in mortality. National vital statistics have shown a leveling of cardiovascular disease death rates in the fifth decade of life. Public health efforts have begun to address childhood obesity. This article reviews the dyslipidemia associated with obesity in childhood and outlines a proposed approach to management.
authors.affiliation: Department of Pediatrics, Golisano Children's Hospital, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 777, Rochester, NY 14642, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Cook
authors.forename: Rae Ellen W
authors.initials: RE
authors.lastname: Kavey
mesh_terms: D000293:Adolescent; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004032:Diet; D050171:Dyslipidemias / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D015444:Exercise; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology*; D015995:Prevalence; D014481:United States / Q000453:epidemiology
chemical_list: D000960:Hypolipidemic Agents
references.citation: Int J Obes Relat Metab Disord. 1999 Aug;23(8):889-95
references.pmid: 10490792
references.citation: J Am Coll Cardiol. 2010 Sep 21;56(13):1034-41
references.pmid: 20846602
references.citation: J Pediatr. 2008 Feb;152(2):165-70
references.pmid: 18206683
references.citation: J Pediatr. 2008 Jun;152(6):873-8
references.pmid: 18492534
references.citation: Circulation. 2011 Mar 1;123(8):933-44
references.pmid: 21262990
references.citation: Arch Dis Child. 1985 Jan;60(1):34-7
references.pmid: 3882058
references.citation: Circulation. 2002 Oct 8;106(15):1930-7
references.pmid: 12370215
references.citation: N Engl J Med. 2007 Sep 27;357(13):1301-10
references.pmid: 17898099
references.citation: Arterioscler Thromb Vasc Biol. 2008 May;28(5):1012-7
references.pmid: 18309111
references.citation: Circulation. 2006 Jan 3;113(1):20-9
references.pmid: 16380547
references.citation: Arteriosclerosis. 1990 Mar-Apr;10(2):223-31
references.pmid: 2180396
references.citation: J Pediatr. 2007 Jan;150(1):12-17.e2
references.pmid: 17188605
references.citation: N Engl J Med. 2007 Jun 7;356(23):2388-98
references.pmid: 17554120
references.citation: Med Sci Sports Exerc. 2002 Dec;34(12):1920-7
references.pmid: 12471297
references.citation: Am J Clin Nutr. 2005 May;81(5):976-82
references.pmid: 15883418
references.citation: J Pediatr. 2004 May;144(5):620-5
references.pmid: 15126996
references.citation: Pediatrics. 1992 Mar;89(3):495-501
references.pmid: 1741227
references.citation: JAMA. 2007 May 16;297(19):2092-102
references.pmid: 17507345
references.citation: J Clin Endocrinol Metab. 2008 Nov;93(11):4200-9
references.pmid: 18697860
references.citation: Arch Pediatr Adolesc Med. 2003 Aug;157(8):773-9
references.pmid: 12912783
references.citation: Int J Obes Relat Metab Disord. 2000 Oct;24(10):1286-96
references.pmid: 11093290
references.citation: Circulation. 2002 Jun 11;105(23):2712-8
references.pmid: 12057983
references.citation: Eur J Pediatr. 1993 Nov;152(11):939-43
references.pmid: 8276030
references.citation: Curr Opin Endocrinol Diabetes Obes. 2008 Apr;15(2):167-74
references.pmid: 18316953
references.citation: Am J Dis Child. 1989 Apr;143(4):454-7
references.pmid: 2929526
references.citation: Pediatrics. 2006 Nov;118(5):e1390-8
references.pmid: 17079540
references.citation: Atherosclerosis. 2011 Jan;214(1):220-4
references.pmid: 21122858
references.citation: J Pediatr. 2003 Mar;142(3):253-8
references.pmid: 12640371
references.citation: JAMA. 2004 Nov 24;292(20):2482-90
references.pmid: 15562127
references.citation: JAMA. 2010 Jan 20;303(3):242-9
references.pmid: 20071470
references.citation: Pediatrics. 2005 Apr;115(4):e443-9
references.pmid: 15805347
references.citation: Obesity (Silver Spring). 2009 Sep;17(9):1768-75
references.pmid: 19498345
references.citation: Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1998-2004
references.pmid: 10938023
references.citation: J Clin Lipidol. 2007 Dec;1(6):583-92
references.pmid: 19657464
references.citation: J Pediatr. 2005 Jun;146(6):732-7
references.pmid: 15973308
references.citation: Pediatrics. 2004 Dec;114(6):1534-44
references.pmid: 15574612
references.citation: N Engl J Med. 1998 Jun 4;338(23):1650-6
references.pmid: 9614255
references.citation: Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1175-80
references.pmid: 12117734
references.citation: Am J Cardiol. 2005 Apr 1;95(7):869-71
references.pmid: 15781019
references.citation: Circulation. 2007 Oct 16;116(16):1832-44
references.pmid: 17938300
references.citation: Circulation. 2009 Mar 3;119(8):1108-15
references.pmid: 19221218
references.citation: Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):794-801
references.pmid: 8640407
references.citation: MMWR Morb Mortal Wkly Rep. 2010 Jan 22;59(2):29-33
references.pmid: 20094024
references.citation: Pediatrics. 1988 May;81(5):605-12
references.pmid: 3357722
references.citation: Pediatrics. 1993 Jul;92(1):78-82
references.pmid: 8516088
references.citation: N Engl J Med. 2007 Dec 6;357(23):2371-9
references.pmid: 18057339
references.citation: Atherosclerosis. 2002 Aug;163(2):287-96
references.pmid: 12052475
references.citation: Circulation. 2005 Oct 25;112(17):2735-52
references.pmid: 16157765
references.citation: Pediatrics. 2008 Jul;122(1):198-208
references.pmid: 18596007
references.citation: Circulation. 2004 Apr 27;109(16):1981-6
references.pmid: 15066949
references.citation: Arch Pediatr Adolesc Med. 2003 Aug;157(8):821-7
references.pmid: 12912790
references.citation: Acad Pediatr. 2009 Sep-Oct;9(5):322-9
references.pmid: 19560993
references.citation: Lipids. 2010 Oct;45(10):907-14
references.pmid: 20524075
references.citation: J Am Coll Cardiol. 2007 Nov 27;50(22):2128-32
references.pmid: 18036449