title: [The multidisciplinary practice guideline "The responsible use of biologicals"].
abstract: A multidisciplinary working group has developed a practice guideline containing various recommendations on the responsible and efficient use of biologicals. These biologicals include both soluble immune-receptor proteins and monoclonal antibodies that are aimed at immune mediators, receptors or cells. They are produced by biotechnology. Biologicals are used to treat patients with immune-mediated inflammatory disorders (IMIDs) such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis, juvenile idiopathic arthritis (JIA), psoriasis, ulcerative colitis, Crohn's disease, uveitis and sarcoidosis. This article summarises the most important recommendations contained in the practice guideline. The practice guideline is intended for members of the medical profession in addition to patients, who are considering, or are already, using biologicals.
authors.affiliation: Universitair Medisch Centrum Utrecht, afd. Reumatologie & Klinische Immunologie, Utrecht, the Netherlands.
authors.forename: J W J Hans
authors.initials: JW
authors.lastname: Bijlsma
authors.forename: J W Annemarie
authors.initials: JW
authors.lastname: Hagemeijer
authors.forename: Marc
authors.initials: M
authors.lastname: Bijl
authors.forename: Tim L Th A
authors.initials: TL
authors.lastname: Jansen
authors.forename: Mart A F J
authors.initials: MA
authors.lastname: van de Laar
authors.forename: Robert B M
authors.initials: RB
authors.lastname: Landewé
authors.forename: Mike T
authors.initials: MT
authors.lastname: Nurmohamed
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy*; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D001688:Biological Products; D007155:Immunologic Factors