title: α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking.
abstract: Extensive work in humans using magneto- and electroencephalography strongly suggests that decreased oscillatory α-activity (8-14 Hz) facilitates processing in a given region, whereas increased α-activity serves to actively suppress irrelevant or interfering processing. However, little work has been done to understand how α-activity is linked to neuronal firing. Here, we simultaneously recorded local field potentials and spikes from somatosensory, premotor, and motor regions while a trained monkey performed a vibrotactile discrimination task. In the local field potentials we observed strong activity in the α-band, which decreased in the sensorimotor regions during the discrimination task. This α-power decrease predicted better discrimination performance. Furthermore, the α-oscillations demonstrated a rhythmic relation with the spiking, such that firing was highest at the trough of the α-cycle. Firing rates increased with a decrease in α-power. These findings suggest that α-oscillations exercise a strong inhibitory influence on both spike timing and firing rate. Thus, the pulsed inhibition by α-oscillations plays an important functional role in the extended sensorimotor system.
authors.affiliation: Donders Institute for Brain, Cognition, and Behaviour,  Radboud University Nijmegen, 6500HB Nijmegen,  The Netherlands.
authors.forename: Saskia
authors.initials: S
authors.lastname: Haegens
authors.forename: Verónica
authors.initials: V
authors.lastname: Nácher
authors.forename: Rogelio
authors.initials: R
authors.lastname: Luna
authors.forename: Ranulfo
authors.initials: R
authors.lastname: Romo
authors.forename: Ole
authors.initials: O
authors.lastname: Jensen
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000513:Alpha Rhythm / Q000502:physiology*; D000818:Animals; D004192:Discrimination, Psychological / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010812:Physical Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D013057:Spectrum Analysis; D014732:Vibration
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