title: Combination treatment using bipolar radiofrequency-based intense pulsed light, infrared light and diode laser enhanced clinical effectiveness and histological dermal remodeling in Asian photoaged skin.
abstract: BACKGROUND
  Combined optical and bipolar radiofrequency (RF) devices have been effective for rejuvenation, but a single modality in one session cannot solve three-dimensional skin complaints, resulting in time-consuming visits.
  
  
  OBJECTIVE
  To evaluate the safety and efficacy of single-session triple treatment using bipolar RF-based optical (intense pulsed light [IPL], infrared light, and diode laser) combination devices for treatment of photoaged Asian skin.
  
  
  METHODS
  In a split-face trial, 11 women received four treatments at 3-week intervals consisting of the combination of sequential IPL, infrared light, and diode laser, all with RF, in one session. Outcome assessments included photography, global evaluation by blinded investigators, patient assessment, and objective biophysical measurements of color and elasticity. Punch biopsies were obtained from both sides of the face 1 month after the last treatment session.
  
  
  RESULTS
  All patients showed statistically significant reduction in photoaging global score. Objective biophysical measurements showed significant improvements in melanin index and elasticity (R5, R7), as well as increases in the levels of procollagen type I and III and elastin.
  
  
  CONCLUSIONS
  A combination of three different energy sources, with bipolar RF, in one session is effective without further downtime for solving multiple problems including tone, texture, and laxity observed in photoaged Asian skin.
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Songpagu, Seoul, Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Sungeun
authors.initials: S
authors.lastname: Chang
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Chae Hwa
authors.initials: CH
authors.lastname: Kim
authors.forename: Kyeong Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Jee Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
mesh_terms: D044466:Asian People; D003131:Combined Modality Therapy; D020405:Dermis / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007259:Infrared Rays; D053685:Laser Therapy; D054023:Lasers, Semiconductor; D008875:Middle Aged; D010789:Phototherapy; D061208:Pulsed Radiofrequency Treatment; D012060:Rejuvenation; D015595:Skin Aging / Q000528:radiation effects*