title: Anti-cyclic citrullinated peptide antibodies in adult patients with juvenile idiopathic arthritis.
abstract: BACKGROUND
  Antibodies to cyclic citrullinated peptide (anti-CCP) have been found in different proportions in the juvenile idiopathic arthritis (JIA) population. The majority of studies have been done in children or mixed population (children plus adults).
  
  
  OBJECTIVE
  The objective of the study was to study the prevalence of anti-CCP in JIA adult patients.
  
  
  METHODS
  Anti-CCP3 was searched for in 49 adult patients with JIA and associated with clinical and demographics data. As comparisons, 156 patients with adult rheumatoid arthritis (RA) and 100 healthy volunteers were studied.
  
  
  RESULTS
  Nine patients (18.3%) were positive for anti-CCP3. All of them had the polyarthritis form. This antibody was more common in JIA than in control subjects (P = 0.0002) and less common in JIA than in adult RA patients (P < 0.0001), but the rheumatoid factor polyarticular form of JIA had the same prevalence as in adult RA patients (P = 0.33).In JIA patients, anti-CCP had a positive association with the presence of rheumatoid factor (P < 0.0001), worse functional status (P = 0.04), need for orthopedic surgery (P = 0.01), and later disease onset (P = 0.0007).
  
  
  CONCLUSIONS
  In adult patients with JIA, the prevalence of anti-CCP3 is 18%, and its presence may define a sample of patients with worse prognosis.
authors.affiliation: Evangelical University Hospital of Curitiba, Paraná, Brazil.
authors.forename: Thelma S
authors.initials: TS
authors.lastname: Skare
authors.forename: Renato M
authors.initials: RM
authors.lastname: Nisihara
authors.forename: Rafael Mourato
authors.initials: RM
authors.lastname: Silva
authors.forename: Danilo J
authors.initials: DJ
authors.lastname: Munhoz da Silva
authors.forename: Marilia B
authors.initials: MB
authors.lastname: Gameiro Silva
authors.forename: Shirley R R
authors.initials: SR
authors.lastname: Utiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001171:Arthritis, Juvenile / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011379:Prognosis; D012217:Rheumatoid Factor / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor