title: Cytochrome c signalosome in mitochondria.
abstract: Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome c that lead to cell death are amazingly stable. Interestingly, the contacts of cytochrome c with its counterparts shift from the area surrounding the heme crevice for the redox complexes to the opposite molecule side when the electron flow is not necessary. The cytochrome c signalosome shows a higher level of regulation by post-translational modifications-nitration and phosphorylation-of the hemeprotein. Understanding protein interfaces, as well as protein modifications, would puzzle the mitochondrial cytochrome c-controlled pathways out and enable the design of novel drugs to silence the action of pro-survival and pro-apoptotic partners of cytochrome c.
authors.affiliation: Instituto de Bioquímica Vegetal y Fotosíntesis, Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla-CSIC, Sevilla, Spain. idiazmoreno@us.es
authors.forename: Irene
authors.initials: I
authors.lastname: Díaz-Moreno
authors.forename: José M
authors.initials: JM
authors.lastname: García-Heredia
authors.forename: Antonio
authors.initials: A
authors.lastname: Díaz-Quintana
authors.forename: Miguel A
authors.initials: MA
authors.lastname: De la Rosa
mesh_terms: D000975:Antioxidants / Q000502:physiology; D017209:Apoptosis / Q000502:physiology*; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism*; D004579:Electron Transport / Q000502:physiology*; D016166:Free Radical Scavengers / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D045304:Cytochromes c
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