title: Overweight and obesity in hemophilia: a systematic review of the literature.
abstract: BACKGROUND
  As life expectancy in individuals with congenital hemophilia approaches that of the general population, we hypothesize that public health risks, including overweight and obesity, also follow a similar trend.
  
  
  METHODS
  A search of the literature included terms relating to overweight, sequelae of being overweight, and hemophilia. Studies were included if they reported the frequency or clinical significance of known complications of overweight and obesity, including musculoskeletal disease, aerobic capacity, cardiovascular disease, diabetes, hyperlipidemia, decreased quality of life, and change in pharmacokinetics of infused clotting factor in hemophilia. Recommendations from medical organizations were searched for preventive and management strategies applicable to this population.
  
  
  RESULTS
  Overweight and obesity are now more prevalent in the hemophilia population than previous generations, with rates similar to and, in certain subsets even higher, than that of the general population. Increased BMI leads to limitations in joint range of motion in the general population and even more so in persons with hemophilia.
  
  
  CONCLUSIONS
  Overweight and obesity in hemophilia are an increasing problem. Simple steps can be taken to encourage patients to decrease caloric intake and increase physical activity. Prevention and management of overweight, obesity, and their sequelae must be addressed in clinical practice in order to maximize the overall health of the hemophilia population.
authors.affiliation: Puget Sound Blood Center, University of Washington, Seattle, Washington, USA. trishaw@psbc.org
authors.forename: Trisha E
authors.initials: TE
authors.lastname: Wong
authors.forename: Suvankar
authors.initials: S
authors.lastname: Majumdar
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Adams
authors.forename: Sarah
authors.initials: S
authors.lastname: Bergman
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Damiano
authors.forename: Joann
authors.initials: J
authors.lastname: Deutsche
authors.forename: Michael
authors.initials: M
authors.lastname: Recht
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005060:Europe / Q000453:epidemiology; D006467:Hemophilia A / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000150:complications / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D055815:Young Adult