title: Hypersensitive reaction to praziquantel in a clonorchiasis patient.
abstract: Praziquantel is the drug of choice for clonorchiasis. Since clonorchiasis is endemic in most river basins, praziquantel has been widely used for 30 years in Korea. A 54-year-old Korean woman suffered from hypersensitive reactions, such as nausea, dyspnea, rash, and urticaria after taking the first dose of praziquantel to treat clonorchiasis. She ingested one dose again and the same symptoms appeared, and she was treated at a clinic with anti-histamines. She tried one more dose with anti-histamines but found the same symptoms. Later, she was found to pass eggs of Clonorchis sinensis and medicated with flubendazole. The hypersensitive reaction to praziquantel is rare but occurs. This is the 5th case report in the world.
authors.affiliation: Department of Parasitology and Tropical Medicine, and Institute of Endemic Diseases, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Hyun-Sul
authors.initials: HS
authors.lastname: Lim
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Hong
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects*; D003003:Clonorchiasis / Q000150:complications* / Q000188:drug therapy*; D003004:Clonorchis sinensis / Q000302:isolation & purification; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005243:Feces / Q000469:parasitology; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage; D006801:Humans; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D011223:Praziquantel / Q000008:administration & dosage* / Q000009:adverse effects*; D056910:Republic of Korea
chemical_list: D000871:Anthelmintics; D006633:Histamine Antagonists; D011223:Praziquantel; D008463:Mebendazole; C018945:flubendazole
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