title: [Chromosomal translocations in soft tissue sarcomas: from molecular biology to clinical application].
abstract: Recent advances in the knowledge of the molecular biology of paediatric sarcomas, especially the characterisation of chromosomal translocations associated specifically with particular types of cancer, have established bases for the introduction of new diagnostic tools. This article reviews the main chromosomal translocations associated with paediatric tumours, and summarises their molecular characteristics regarding their oncogenic capabilities, possible usefulness as a differential diagnostic tools and possible correlation with clinical parameters.
authors.affiliation: Grupo de Investigación translacional en el cáncer del niño, Institut de Recerca, Vall d'Hebron, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Roma
authors.forename: A
authors.initials: A
authors.lastname: Masià
authors.forename: A
authors.initials: A
authors.lastname: Almazán-Moga
authors.forename: M
authors.initials: M
authors.lastname: Rebull
authors.forename: P
authors.initials: P
authors.lastname: Velasco
authors.forename: S
authors.initials: S
authors.lastname: Gallego
authors.forename: J
authors.initials: J
authors.lastname: Sánchez de Toledo
mesh_terms: D002648:Child; D006801:Humans; D008967:Molecular Biology; D012509:Sarcoma / Q000175:diagnosis* / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D014178:Translocation, Genetic