title: Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats.
abstract: In the present study, we aimed to examine the effects of soya oligosaccharides (SOS) and soya oligopeptides (SOP) on blood lipid levels, release of vasoactive substances, antioxidant activity and faecal bile acid (FBA) excretion in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were evenly divided into five groups according to diets as follows: regular diet (control), HFD, HFD enriched with 2 % of SOS (SOS), HFD enriched with 3 % of SOP (SOP) and HFD enriched with 2 % SOS and 3 % SOP (SOSP). The results showed that SOS and SOP significantly reduced plasma total cholesterol, LDL-cholesterol and TAG, whereas HDL-cholesterol concentration was significantly increased. Furthermore, SOS and SOP reduced plasma apoB, apoE and the apoB:apoAI ratio, whereas apoAI was significantly increased. Moreover, SOS and SOP also reduced plasma thromboxane A₂ (TXA₂) and the TXA₂:prostacyclin (PGI₂) ratio, whereas plasma PGI₂ and nitric oxide were significantly increased. In addition, SOS and SOP significantly reduced serum and liver malondialdehyde concentrations and increased FBA excretion. However, we did not observe obvious influences of SOS and SOP on superoxide dismutase activities in the liver of HFD-fed rats. The combination of 2 % SOS and 3 % SOP showed a more marked effect than SOS or SOP alone in improving the lipid profile, release of vasoactive substances and increasing FBA excretion (P < 0.05). In summary, SOS and SOP might help prevent atherosclerosis through improving abnormal blood lipid levels, regulating vasoactive substances and protecting against oxidative stress.
authors.affiliation: West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Shali
authors.initials: S
authors.lastname: Xie
authors.forename: Jundong
authors.initials: J
authors.lastname: Zhu
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Shi
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Shi
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D001053:Apolipoproteins / Q000097:blood; D001647:Bile Acids and Salts / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D015777:Eicosanoids / Q000097:blood; D005243:Feces / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000627:therapeutic use*; D009844:Oligosaccharides / Q000627:therapeutic use*; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D030262:Soybean Proteins / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001053:Apolipoproteins; D001647:Bile Acids and Salts; D015777:Eicosanoids; D008055:Lipids; D009842:Oligopeptides; D009844:Oligosaccharides; D030262:Soybean Proteins; D013482:Superoxide Dismutase