title: [Changing the protective properties of the receptor domain of protective antigen anthrax exotoxin, depending on the orientation of the presentation on nanoparticles].
abstract: Polysterene particles bearing on its surface recombinant protein receptor domain of protective antigen anthrax exotoxin, exposed in different orientations have been constructed. Particles with exposed COOH region of receptor domain induced the highest protective immunity in mice anthrax model (95%). We revealed that immunization with these particles causes a specific induction of Th1-response, characterized by increased levels ofcytokine TNF-alpha and IL-2.
authors.forename: K A
authors.initials: KA
authors.lastname: Noskov
authors.forename: O N
authors.initials: ON
authors.lastname: Shcheglovitova
authors.forename: O D
authors.initials: OD
authors.lastname: Skliarov
authors.forename: A N
authors.initials: AN
authors.lastname: Noskov
mesh_terms: D000818:Animals; D000881:Anthrax / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000737:chemistry / Q000276:immunology; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D001408:Bacillus anthracis / Q000276:immunology; D001427:Bacterial Toxins / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D053758:Nanoparticles / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: D022122:Anthrax Vaccines; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin