title: Modeling powder encapsulation in dosator-based machines: II. Experimental evaluation.
abstract: A theoretical model was previously derived to predict powder encapsulation in dosator-based machines. The theoretical basis of the model was discussed earlier. In this part; the model was evaluated experimentally using two powder formulations with substantially different flow behavior. Encapsulation experiments were performed using a Zanasi encapsulation machine under two sets of experimental conditions. Model predicted outcomes such as encapsulation fill weight and plug height were compared to those experimentally obtained. Results showed a high correlation between predicted and actual outcomes demonstrating the model's success in predicting the encapsulation of both formulations. The model is a potentially useful in silico analysis tool that can be used for capsule dosage form development in accordance to quality by design (QbD) principles.
authors.affiliation: Department of Pharmaceutics, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877, USA. ammar.khawam@boehringer-ingelheim.com
authors.forename: Ammar
authors.initials: A
authors.lastname: Khawam
authors.forename: Leon
authors.initials: L
authors.lastname: Schultz
mesh_terms: D002214:Capsules; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D011208:Powders; D012212:Rheology
chemical_list: D002214:Capsules; D011208:Powders