title: Artificial sweetener use among children: epidemiology, recommendations, metabolic outcomes, and future directions.
abstract: This review summarizes the literature pertaining to the epidemiology and current recommendations for pediatric artificial sweetener use and presents the results of studies investigating metabolic responses to artificial sweeteners among children. An understanding of the research previously conducted and the gaps that remain will inform future clinical and translational research, to develop evidence-based recommendations for artificial sweetener use in the prevention and treatment of pediatric obesity.
authors.affiliation: Graduate Division of Biological and Biomedical Sciences, Emory University, 1462 Clifton Road, Suite 314, Atlanta, GA 30322, USA. asylvet@emory.edu
authors.forename: Allison
authors.initials: A
authors.lastname: Sylvetsky
authors.forename: Kristina I
authors.initials: KI
authors.lastname: Rother
authors.forename: Rebecca
authors.initials: R
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D016739:Behavior, Addictive / Q000139:chemically induced; D001786:Blood Glucose / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009765:Obesity / Q000517:prevention & control*; D013549:Sweetening Agents / Q000009:adverse effects / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D013549:Sweetening Agents
references.citation: Neuroimage. 2011 Jan 15;54(2):1367-74
references.pmid: 20804848
references.citation: Crit Rev Toxicol. 2007;37(8):629-727
references.pmid: 17828671
references.citation: Am J Clin Nutr. 2006 Aug;84(2):274-88
references.pmid: 16895873
references.citation: Am J Clin Nutr. 2010 May;91(5):1499S-1505S
references.pmid: 20335542
references.citation: Pediatr Res. 2007 Jun;61(6):745-9
references.pmid: 17426650
references.citation: Int J Food Sci Nutr. 2003 Jul;54(4):297-307
references.pmid: 12850891
references.citation: J Am Coll Nutr. 2005 Apr;24(2):93-8
references.pmid: 15798075
references.citation: J Chromatogr A. 2010 Feb 26;1217(9):1463-70
references.pmid: 20102764
references.citation: Eur J Clin Nutr. 2011 Apr;65(4):508-13
references.pmid: 21245879
references.citation: Arch Pediatr Adolesc Med. 2003 Sep;157(9):882-6
references.pmid: 12963593
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15075-80
references.pmid: 17724332
references.citation: J Nutr Sci Vitaminol (Tokyo). 1985 Oct;31(5):533-40
references.pmid: 3908628
references.citation: Appetite. 2007 Nov;49(3):644-51
references.pmid: 17537539
references.citation: Am J Clin Nutr. 1997 Feb;65(2):409-18
references.pmid: 9022524
references.citation: Neuroscience. 2005;134(3):737-44
references.pmid: 15987666
references.citation: Diabetes Care. 2009 Dec;32(12):2184-6
references.pmid: 19808921
references.citation: Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G735-9
references.pmid: 19221011
references.citation: Obesity (Silver Spring). 2008 Aug;16(8):1894-900
references.pmid: 18535548
references.citation: J Pediatr. 2006 Feb;148(2):183-7
references.pmid: 16492426
references.citation: Pediatrics. 2006 Oct;118(4):e1010-8
references.pmid: 17015497
references.citation: Clin Nutr. 2010 Jun;29(3):288-303
references.pmid: 20056521
references.citation: Obesity (Silver Spring). 2008 Aug;16(8):1802-8
references.pmid: 18535546
references.citation: FDA Consum. 2006 Jul-Aug;40(4):27-8
references.pmid: 17243285
references.citation: Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R632-9
references.pmid: 19535679
references.citation: Br J Nutr. 2011 May;105(9):1320-8
references.pmid: 21255472
references.citation: J Toxicol Environ Health. 1976 Nov;2(2):417-28
references.pmid: 796476
references.citation: Nat Neurosci. 2005 May;8(5):555-60
references.pmid: 15856062
references.citation: Physiol Behav. 1989 Jun;45(6):1093-9
references.pmid: 2813533
references.citation: Chem Senses. 2011 Nov;36(9):763-70
references.pmid: 21653241
references.citation: Int J Food Sci Nutr. 2007 May;58(3):217-30
references.pmid: 17514539
references.citation: J Am Diet Assoc. 2004 Feb;104(2):255-75
references.pmid: 14760578
references.citation: Am J Clin Nutr. 2009 Jun;89(6):1723-8
references.pmid: 19369382
references.citation: Brain Res Mol Brain Res. 2004 May 19;124(2):134-42
references.pmid: 15135221
references.citation: Am J Clin Nutr. 2006 Jun;83(6):1276-82
references.pmid: 16762937
references.citation: Br J Nutr. 2010 Sep;104(6):803-6
references.pmid: 20420761
references.citation: Lancet. 2001 Feb 17;357(9255):505-8
references.pmid: 11229668
references.citation: Am J Clin Nutr. 2009 Jan;89(1):1-14
references.pmid: 19056571
references.citation: Appetite. 2004 Dec;43(3):235-45
references.pmid: 15527925
references.citation: Addiction. 2010 Apr;105(4):666-75
references.pmid: 20148789
references.citation: J Am Diet Assoc. 2003 Dec;103(12):1607-12
references.pmid: 14647086
references.citation: Am J Clin Nutr. 2011 Sep;94(3):726-34
references.pmid: 21753067
references.citation: Neurosci Biobehav Rev. 2008;32(1):20-39
references.pmid: 17617461
references.citation: Pediatrics. 2006 Mar;117(3):673-80
references.pmid: 16510646
references.citation: Appetite. 1996 Aug;27(1):25-40
references.pmid: 8879417
references.citation: Appetite. 1989 Oct;13(2):93-103
references.pmid: 2802596
references.citation: Am J Clin Nutr. 2007 Mar;85(3):651-61
references.pmid: 17344485
references.citation: Nutrition. 2007 Jul-Aug;23(7-8):557-63
references.pmid: 17616342
references.citation: Am J Clin Nutr. 1994 Feb;59(2):338-45
references.pmid: 8310983
references.citation: Lancet. 1986 May 10;1(8489):1092-3
references.pmid: 2871354
references.citation: Pediatrics. 2007 Oct;120(4):e869-79
references.pmid: 17908743
references.citation: J Am Diet Assoc. 1995 Sep;95(9):993-8
references.pmid: 7657914
references.citation: Behav Neurosci. 2009 Aug;123(4):772-80
references.pmid: 19634935
references.citation: Early Hum Dev. 2000 Jul;59(1):51-60
references.pmid: 10962167
references.citation: Appetite. 1986 Dec;7(4):323-31
references.pmid: 3789709
references.citation: Int J Obes (Lond). 2006 Nov;30(11):1685-92
references.pmid: 16552399
references.citation: Physiol Behav. 2002 Feb 1-15;75(1-2):83-90
references.pmid: 11890956
references.citation: Physiol Behav. 1995 Jun;57(6):1089-95
references.pmid: 7652029
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15069-74
references.pmid: 17724330
references.citation: Am J Clin Nutr. 1997 Mar;65(3):737-43
references.pmid: 9062523
references.citation: Int J Pediatr Obes. 2010 Aug;5(4):305-12
references.pmid: 20078374
references.citation: Obes Res. 2004 May;12(5):778-88
references.pmid: 15166298
references.citation: Physiol Behav. 1989 Feb;45(2):387-95
references.pmid: 2756027
references.citation: Br J Nutr. 2010 Nov;104(10):1415-20
references.pmid: 20619074
references.citation: Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):391-5
references.pmid: 21505330
references.citation: J Psychoactive Drugs. 2010 Jun;42(2):147-51
references.pmid: 20648910
references.citation: J Physiol. 2007 Jul 1;582(Pt 1):379-92
references.pmid: 17495045
references.citation: Neuron. 2008 Mar 27;57(6):930-41
references.pmid: 18367093