title: The prognostic value of serial leukocyte adhesion molecules in post-aneurysmal subarachnoid hemorrhage.
abstract: BACKGROUND
  Leukocyte recruitment and inflammatory response play an important role in the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH). We determined whether leukocyte adhesion molecules after aneurysmal SAH can predict the presence of delayed cerebral infarction (DCI).
  
  
  METHODS
  Serial changes in P-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets were prospectively examined using flow cytometry at various time points in 20 acute aneurysmal SAH patients and 21 healthy volunteers who were free of medications were enrolled as a control group.
  
  
  RESULTS
  Neutrophil (cut-off value of >44.90) and monocyte (cut-off value of >32.95) PSGL-1 expressions on admission were significantly higher in patients with DCI than in non-DCI patients, but the difference between neutrophil PGSL-1 and monocyte PGSL-1 levels between the two groups was no longer significant from Day 4 to Day 14 after aneurysmal SAH. After stepwise logistic regression analysis, only neutrophil PSGL-1 expression upon admission was independently associated with DCI. The mean hospitalization days were 44.4±26.2 for those patients with DCI and 40.5±26.4 for non-DCI patients. After a minimum 6-month follow-up period, the median BI score was 20 for DCI patients and 80 for non-DCI patients.
  
  
  CONCLUSIONS
  Higher expressions of neutrophil PSGL-1 on admission may imply a danger of DCI in patients with aneurysmal SAH.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Yuan's General Hospital, Kaohsiung, Taiwan.
authors.forename: Tzu-Ming
authors.initials: TM
authors.lastname: Yang
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Lin
authors.forename: Nai-Wen
authors.initials: NW
authors.lastname: Tsai
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Lin
authors.forename: Jih-Tsun
authors.initials: JT
authors.lastname: Ho
authors.forename: Wen-Neng
authors.initials: WN
authors.lastname: Chang
authors.forename: Ben-Chung
authors.initials: BC
authors.lastname: Cheng
authors.forename: Chia-Te
authors.initials: CT
authors.lastname: Kung
authors.forename: Tsung-Han
authors.initials: TH
authors.lastname: Lee
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Huang
authors.forename: Hung-Chen
authors.initials: HC
authors.lastname: Wang
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lu
mesh_terms: D015815:Cell Adhesion Molecules / Q000097:blood*; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications*; D013997:Time Factors
chemical_list: D015815:Cell Adhesion Molecules