title: [Biomarkers in spinal fluid of patients with dementia].
abstract: BACKGROUND
  We wanted to assess whether biomarkers abeta42, tau and p-tau could differentiate between Alzheimer's disease and other dementia illnesses.
  
  
  METHODS
  Following systematic Pubmed searches, 25 articles which reported sensitivity and specificity for Alzheimer's disease and other dementias were included.
  
  
  RESULTS
  Most studies showed significant differences for all three markers between Alzheimer's disease and other dementia illnesses, except abeta42 which did not differ between Alzheimer's disease and dementia with Lewy bodies. Alzheimer's disease was distinguished from vascular dementia with sensitivities and specificities 77 % - 87 % and 62-80 % (abeta42); 79-100 % and 14-100 % (tau); and 78-80 % and 63-96 % (p-tau181). Alzheimer's disease and dementia with Lewy bodies were differentiated by tau and p-tau181 with sensitivities and specificities of 72-94 % and 53-92 %, and of 68-85 % and 61-85 %. Markers separated Alzheimer's disease from frontal lobe dementia with sensitivities and specificities of 37-91 % and 59-92 % (abeta42), 58-88 % and 68-92 % (tau) and 44-91 % and 79-100 % (p-tau181).
  
  
  CONCLUSIONS
  Methodological weaknesses impede the interpretation. CSF markers are not yet sufficient to differentiate between Alzheimer's disease and other forms of dementia.
authors.affiliation: Institutt for klinisk medisin, Universitetet i Bergen.
authors.forename: Ragnhild Eide
authors.initials: RE
authors.lastname: Skogseth
authors.forename: Tormod
authors.initials: T
authors.lastname: Fladby
authors.forename: Ezra
authors.initials: E
authors.lastname: Mulugeta
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid*; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid; D057180:Frontotemporal Dementia / Q000134:cerebrospinal fluid; D006801:Humans; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid; D012680:Sensitivity and Specificity; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins