title: Health-related quality of life in pediatric patients with long-standing pancreatitis.
abstract: OBJECTIVE
  There are limited data on health-related quality of life (HRQOL) in pediatric patients with long-standing pancreatitis (including acute relapsing and chronic pancreatitis) using age-appropriate measurement instruments.
  
  
  METHODS
  We evaluated HRQOL in children with long-standing pancreatitis using the PedsQL 4.0 Generic Core Scales by patient self-report as well as parent proxy report. Additionally, patient self-reports and parent proxy reports were completed for the PedsQL Multidimensional Fatigue Scale.
  
  
  RESULTS
  Across all of the dimensions, significantly impaired HRQOL and higher fatigue were noted for both pediatric patient self-report and parent proxy report in comparison with the matched healthy children samples. Higher fatigue was associated with lower HRQOL. There was moderate to good agreement between patient self-reports and parent proxy reports.
  
  
  CONCLUSIONS
  Given the impaired HRQOL and fatigue documented in the present study, future studies are needed to determine whether specific factors can modify HRQOL and fatigue in this patient population.
authors.affiliation: Division of Pediatric Gastroenterology, Primary Children's Medical Center, University of Utah, Salt Lake City, UT 84113-1103, USA. john.pohl@imail.org
authors.forename: John F
authors.initials: JF
authors.lastname: Pohl
authors.forename: Christine A
authors.initials: CA
authors.lastname: Limbers
authors.forename: Marie
authors.initials: M
authors.lastname: Kay
authors.forename: Annette
authors.initials: A
authors.lastname: Harman
authors.forename: Michael
authors.initials: M
authors.lastname: Rollins
authors.forename: James W
authors.initials: JW
authors.lastname: Varni
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005221:Fatigue / Q000150:complications / Q000503:physiopathology; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000503:physiopathology*; D010372:Pediatrics / Q000379:methods*; D019727:Proxy; D011788:Quality of Life; D057566:Self Report; D018434:Sickness Impact Profile