title: Clinical pathology of Greyhounds and other sighthounds.
abstract: Owing to the development of Greyhounds as racing sighthounds, these dogs have acquired unique physiologic adaptations that distinguish them from other breeds. Reference intervals for many analytes in retired racing Greyhounds (RRGs) differ from those of other breeds; most of the hematologic differences have also been described in other sighthounds. In this review, we provide a survey of the literature on clinical pathology of Greyhounds and other sighthounds and results of laboratory testing, including analysis of CBCs, biochemical profiles, coagulation tests, and blood gases, in RRGs at The Ohio State University. Major clinicopathologic differences in this breed include higher RBC mass, creatinine concentration, glomerular filtration rate, activities of hepatic enzymes, and concentration of cardiac troponin, as well as lower WBC, neutrophil, and platelet counts, thromboelastographic values, and concentrations of serum haptoglobin, total globulins, and T4.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.|Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: S
authors.initials: S
authors.lastname: Zaldívar-López
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Marín
authors.affiliation: Veterinary Medical Center, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Iazbik
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.|Veterinary Medical Center, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: N
authors.initials: N
authors.lastname: Westendorf-Stingle
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hensley
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.|Veterinary Medical Center, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.|Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Couto
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood* / Q000652:urine; D004285:Dogs / Q000097:blood* / Q000652:urine; D004573:Electrolytes / Q000097:blood / Q000652:urine; D004909:Erythrocyte Indices / Q000662:veterinary; D006403:Hematologic Tests / Q000662:veterinary*; D006454:Hemoglobins / Q000032:analysis; D006487:Hemostasis; D008099:Liver / Q000201:enzymology; D012016:Reference Values; D013045:Species Specificity; D013963:Thyroid Hormones / Q000097:blood; D014336:Troponin / Q000097:blood
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D006454:Hemoglobins; D013963:Thyroid Hormones; D014336:Troponin; D003404:Creatinine
references.citation: J Vet Intern Med. 2003 Jul-Aug;17(4):593-6
references.pmid: 12892315
references.citation: J Am Vet Med Assoc. 1971 Dec 1;159(11):1603-6
references.pmid: 5153880
references.citation: Blood. 2003 Jun 1;101(11):4416-22
references.pmid: 12576335
references.citation: J Am Vet Med Assoc. 2010 Feb 1;236(3):302-8
references.pmid: 20113242
references.citation: Vet Clin Pathol. 2004;33(1):32-8
references.pmid: 15048625
references.citation: J Vet Intern Med. 2009 Jan-Feb;23(1):87-90
references.pmid: 19175726
references.citation: Am J Vet Res. 2001 Dec;62(12):1969-72
references.pmid: 11763190
references.citation: J Natl Med Assoc. 2006 Mar;98(3):398-402
references.pmid: 16573304
references.citation: J Small Anim Pract. 2011 Jan;52(1):4-10
references.pmid: 21143231
references.citation: J Clin Pharm Ther. 2012 Jun;37(3):286-90
references.pmid: 21767284
references.citation: J Anat. 1989 Dec;167:225-33
references.pmid: 2630537
references.citation: Aust Vet J. 1993 Oct;70(10):361-4
references.pmid: 8257312
references.citation: Vet Radiol Ultrasound. 2009 Mar-Apr;50(2):224-9
references.pmid: 19400473
references.citation: Vet Clin Pathol. 2005 Dec;34(4):397-400
references.pmid: 16270267
references.citation: J Vet Intern Med. 2008 Mar-Apr;22(2):374-9
references.pmid: 18346139
references.citation: J Am Vet Med Assoc. 1970 Oct 15;157(8):1064-70
references.pmid: 5475182
references.citation: Hematol Oncol Clin North Am. 2007 Feb;21(1):1-11
references.pmid: 17258114
references.citation: J Vet Intern Med. 2007 Jan-Feb;21(1):107-12
references.pmid: 17338157
references.citation: Clin Hemorheol Microcirc. 1998 Jul;18(4):291-8
references.pmid: 9741670
references.citation: J Vet Intern Med. 2006 Jan-Feb;20(1):78-82
references.pmid: 16496926
references.citation: Blood Coagul Fibrinolysis. 2011 Apr;22(3):167-75
references.pmid: 21330915
references.citation: Am J Vet Res. 1988 Oct;49(10):1722-5
references.pmid: 3142321
references.citation: J Vet Intern Med. 1990 May-Jun;4(3):140-3
references.pmid: 2366222
references.citation: Am J Med. 1973 May;54(5):682-8
references.pmid: 4701949
references.citation: J Vet Intern Med. 2008 May-Jun;22(3):525-33
references.pmid: 18466249
references.citation: Vet Clin Pathol. 2007 Sep;36(3):274-7
references.pmid: 17806076
references.citation: Am J Cardiol. 1978 Jul;42(1):82-8
references.pmid: 150223
references.citation: J Small Anim Pract. 2011 Jun;52(6):301-9
references.pmid: 21627658
references.citation: J Hered. 1999 Jan-Feb;90(1):112-8
references.pmid: 9987916
references.citation: Vet Clin Pathol. 2010 Dec;39(4):436-9
references.pmid: 21198733
references.citation: J Vet Intern Med. 2006 Mar-Apr;20(2):365-70
references.pmid: 16594595
references.citation: Am J Vet Res. 2001 Jul;62(7):1130-3
references.pmid: 11453491
references.citation: Vet Clin Pathol. 2005 Jun;34(2):140-3
references.pmid: 15902666
references.citation: J Am Vet Med Assoc. 1994 Sep 15;205(6):838-41
references.pmid: 7829376
references.citation: J Am Vet Med Assoc. 1972 Dec 15;161(12):1661-4
references.pmid: 4640497
references.citation: Exp Hematol. 1993 Sep;21(10):1316-20
references.pmid: 8135919
references.citation: Am J Vet Res. 2010 Sep;71(9):1033-8
references.pmid: 20807142
references.citation: Vet Clin Pathol. 2009 Jun;38(2):219-23
references.pmid: 19470149
references.citation: J Am Vet Med Assoc. 1986 Jun 1;188(11):1299-303
references.pmid: 3721985
references.citation: Vet J. 2006 Jul;172(1):135-40
references.pmid: 16772138
references.citation: Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):395-402
references.pmid: 21543841
references.citation: Basic Res Cardiol. 1986 Jul-Aug;81(4):417-24
references.pmid: 2946286
references.citation: Am J Vet Res. 1996 May;57(5):739-42
references.pmid: 8723892
references.citation: Aust Vet J. 2006 Nov;84(11):393-7
references.pmid: 17092324
references.citation: Basic Res Cardiol. 1984 Jan-Feb;79(1):98-109
references.pmid: 6233966
references.citation: Vet Clin Pathol. 2003;32(1):40-2
references.pmid: 12655489
references.citation: Nord Vet Med. 1986 May-Jun;38(3):148-55
references.pmid: 3675721
references.citation: Vet Rec. 2007 Nov 3;161(18):616-9
references.pmid: 17982140
references.citation: Vet Clin Pathol. 2010 Dec;39(4):433-5
references.pmid: 21198732
references.citation: J Vet Intern Med. 2006 May-Jun;20(3):544-6
references.pmid: 16734087
references.citation: Vet Radiol Ultrasound. 2007 Jul-Aug;48(4):332-4
references.pmid: 17691632
references.citation: Vet Clin Pathol. 2002;31(2):83-9
references.pmid: 12040490
references.citation: J Vet Emerg Crit Care (San Antonio). 2011 Feb;21(1):24-8
references.pmid: 21288290
references.citation: J Am Vet Med Assoc. 2004 Jan 15;224(2):226-31
references.pmid: 14736066