title: Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine.
abstract: Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.
authors.affiliation: Department of Vaccination and Immune Protection, National Institute for Health and Welfare (THL), Helsinki, Finland. birgit.simell@thl.fi
authors.forename: Birgit
authors.initials: B
authors.lastname: Simell
authors.forename: Anu
authors.initials: A
authors.lastname: Nurkka
authors.forename: Mika
authors.initials: M
authors.lastname: Lahdenkari
authors.forename: Noga
authors.initials: N
authors.lastname: Givon-Lavi
authors.forename: Helena
authors.initials: H
authors.lastname: Käyhty
authors.forename: Ron
authors.initials: R
authors.lastname: Dagan
authors.forename: Jukka
authors.initials: J
authors.lastname: Jokinen
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001770:Blood Bactericidal Activity; D002353:Carrier State / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology; D009895:Opsonin Proteins / Q000097:blood; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D015995:Prevalence; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
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