title: Alien hand syndrome after epilepsia partialis continua: FDG PET and MRI studies.
abstract: Epilepsia partialis continua (EPC) is clinically defined as a syndrome of continuous focal jerking of a body part, usually a distal limb, occurring over hours, days, or even years. It is considered the status epilepticus equivalent of simple partial motor seizures. A 48-year-old right-handed man with a history of traumatic intracranial hemorrhage was admitted for right-sided hemiplegia and drowsiness after complex partial status epilepticus. An EEG showed periodic lateralized epileptiform discharges over the left hemisphere. Brain MRI revealed extensive multifocal encephalomalaciac changes in the left temporo-parieto-occpital lobe and both frontal lobes with some hemorrhagic residual change. After administration of a loading dose of intravenous phenytoin, his mental status returned to normal. However, his weakness only partially improved. [(18)F]Fluorodeoxyglucose PET (FDG-PET) demonstrated severe hypometabolism in the left cerebral hemisphere, including the basal ganglia and thalamus, with cerebellar diaschisis. At the 3-month follow-up, he complained of symptoms of alien hand phenomenon. Follow-up MRI revealed more extensive encephalomalaciac changes in previously noted regions with thinning of the posterior end of the body of the corpus callosum. Moreover, FDG-PET demonstrated persistent severe hypometabolism over the left cerebral hemisphere. We suggest that the alien hand phenomenon was a result of thinning of the corpus callosum related to EPC.
authors.affiliation: Department of Neurology, Myongji Hospital, Kwandong University College of Medicine, Republic of Korea.
authors.forename: Hye Yun
authors.initials: HY
authors.lastname: Kim
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Go Un
authors.initials: GU
authors.lastname: Kim
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Han
authors.forename: Dong-Ick
authors.initials: DI
authors.lastname: Shin
mesh_terms: D055964:Alien Limb Phenomenon / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D004569:Electroencephalography; D017036:Epilepsia Partialis Continua / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18