title: Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward.
abstract: The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.
authors.affiliation: Brookhaven National Laboratory, Upton, NY, USA.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Parvaz
authors.forename: Anna B
authors.initials: AB
authors.lastname: Konova
authors.forename: Dardo
authors.initials: D
authors.lastname: Tomasi
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.forename: Rita Z
authors.initials: RZ
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D004569:Electroencephalography / Q000379:methods*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D012201:Reward
references.citation: J Clin Neurophysiol. 1992 Oct;9(4):456-79
references.pmid: 1464675
references.citation: Annu Rev Neurosci. 2005;28:403-50
references.pmid: 16022602
references.citation: J Cogn Neurosci. 2004 Apr;16(3):463-78
references.pmid: 15072681
references.citation: Brain Cogn. 2004 Jun;55(1):11-29
references.pmid: 15134840
references.citation: Brain Topogr. 2000 Spring;12(3):159-75
references.pmid: 10791680
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):4-26
references.pmid: 19812543
references.citation: Electroencephalogr Clin Neurophysiol. 1984 Feb;59(1):9-20
references.pmid: 6198170
references.citation: Cereb Cortex. 2003 Oct;13(10):1064-71
references.pmid: 12967923
references.citation: Neuropsychopharmacology. 1998 Apr;18(4):243-52
references.pmid: 9509492
references.citation: Neuroimage. 2003 Jul;19(3):1095-102
references.pmid: 12880835
references.citation: Neuropsychologia. 2010 Oct;48(12):3606-13
references.pmid: 20727905
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references.pmid: 10860804
references.citation: Exp Brain Res. 2009 Jan;192(3):489-97
references.pmid: 19030851
references.citation: Psychol Bull. 1981 May;89(3):506-40
references.pmid: 7255627
references.citation: Am J Addict. 2005 Mar-Apr;14(2):106-23
references.pmid: 16019961
references.citation: Prog Brain Res. 1986;70:87-102
references.pmid: 3575751
references.citation: J Subst Abuse. 1993;5(2):117-30
references.pmid: 8400835
references.citation: J Psychiatr Res. 2010 Jul;44(9):576-90
references.pmid: 20035952
references.citation: Eur Arch Psychiatry Clin Neurosci. 2004 Jun;254(3):190-8
references.pmid: 15205974
references.citation: Psychophysiology. 2011 Feb;48(2):162-75
references.pmid: 20557480
references.citation: J Neurosci. 2004 Oct 20;24(42):9353-60
references.pmid: 15496671
references.citation: J Neurosci Methods. 2010 Mar 15;187(1):138-45
references.pmid: 20035787
references.citation: Psychol Bull. 2005 Jul;131(4):510-32
references.pmid: 16060800
references.citation: Psychiatry Res. 1998 Jun 15;79(2):163-73
references.pmid: 9705054
references.citation: Arch Gen Psychiatry. 2011 Mar;68(3):283-94
references.pmid: 21383264
references.citation: Magn Reson Med. 1995 Sep;34(3):308-12
references.pmid: 7500867
references.citation: Neuroimage. 1996 Dec;4(3 Pt 1):223-35
references.pmid: 9345513
references.citation: Electroencephalogr Clin Neurophysiol. 1998 Feb;106(2):156-64
references.pmid: 9741777
references.citation: Clin Neurophysiol. 2007 Oct;118(10):2128-48
references.pmid: 17573239
references.citation: Brain Res. 2010 Oct 8;1355:126-40
references.pmid: 20691670
references.citation: JAMA. 2000 Nov 22-29;284(20):2606-10
references.pmid: 11086367
references.citation: Trends Cogn Sci. 2011 Feb;15(2):56-67
references.pmid: 21216655
references.citation: Am J Psychiatry. 2007 Jan;164(1):43-51
references.pmid: 17202543
references.citation: Am J Drug Alcohol Abuse. 2009;35(1):12-7
references.pmid: 19152200
references.citation: Psychophysiology. 2001 Mar;38(2):343-58
references.pmid: 11347879
references.citation: Int J Psychophysiol. 2006 Nov;62(2):272-9
references.pmid: 16876894
references.citation: Clin Neurophysiol. 2005 Aug;116(8):1808-25
references.pmid: 15996897
references.citation: Arch Gen Psychiatry. 2004 Nov;61(11):1107-15
references.pmid: 15520358
references.citation: Brain. 2009 Nov;132(Pt 11):3002-10
references.pmid: 19713281
references.citation: Neuroimage. 2009 Feb 1;44(3):827-38
references.pmid: 18996205
references.citation: Neuroimage. 2005 Mar;25(1):43-50
references.pmid: 15734342
references.citation: Neuron. 2001 May;30(2):619-39
references.pmid: 11395019
references.citation: Brain Res Bull. 2007 Jul 12;73(4-6):220-30
references.pmid: 17562387
references.citation: Biol Psychiatry. 2002 Jan 15;51(2):134-42
references.pmid: 11822992
references.citation: Hum Brain Mapp. 2007 Aug;28(8):742-63
references.pmid: 17133395
references.citation: Science. 1965 Nov 26;150(3700):1187-8
references.pmid: 5852977
references.citation: IEEE Trans Med Imaging. 2005 Dec;24(12):1548-65
references.pmid: 16350916
references.citation: Psychophysiology. 2008 Sep;45(5):705-13
references.pmid: 18513362
references.citation: Neuroimage. 2004 Mar;21(3):1045-54
references.pmid: 15006672
references.citation: Biol Psychol. 2009 Apr;81(1):1-8
references.pmid: 19162124
references.citation: Am J Psychiatry. 1987 Sep;144(9):1184-8
references.pmid: 3631315
references.citation: J Comp Neurol. 2005 Dec 5;493(1):99-110
references.pmid: 16254995
references.citation: Hum Brain Mapp. 2003 Jan;18(1):53-77
references.pmid: 12454912
references.citation: Neuroreport. 2005 Mar 15;16(4):407-11
references.pmid: 15729147
references.citation: Cereb Cortex. 2007 Sep;17 Suppl 1:i51-60
references.pmid: 17726004
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Psychophysiology. 2005 Mar;42(2):161-70
references.pmid: 15787853
references.citation: Psychophysiology. 1983 Jan;20(1):95-101
references.pmid: 6828618
references.citation: Nat Neurosci. 2001 Jan;4(1):95-102
references.pmid: 11135651
references.citation: Nat Neurosci. 2010 Apr;13(4):507-12
references.pmid: 20208526
references.citation: J Neurosci. 2004 Jul 14;24(28):6258-64
references.pmid: 15254080
references.citation: Neuroreport. 1997 Mar 24;8(5):1225-8
references.pmid: 9175118
references.citation: Neuroimage. 2005 Jul 1;26(3):839-51
references.pmid: 15955494
references.citation: Neuroimage. 2005 May 1;25(4):1325-35
references.pmid: 15850749
references.citation: Clin Neurophysiol. 2010 Jan;121(1):60-76
references.pmid: 19900840
references.citation: J Neurosci. 2003 Jan 1;23(1):303-7
references.pmid: 12514228
references.citation: Synapse. 2010 May;64(5):397-402
references.pmid: 20034014
references.citation: Eur J Neurosci. 2008 Apr;27(7):1823-35
references.pmid: 18380674
references.citation: Psychopharmacology (Berl). 2006 Jun;186(2):191-200
references.pmid: 16612617
references.citation: Cereb Cortex. 2000 Mar;10(3):263-71
references.pmid: 10731221
references.citation: Biol Psychiatry. 2009 Jan 15;65(2):160-4
references.pmid: 18801475
references.citation: Brain Res. 2009 Aug 25;1286:114-22
references.pmid: 19539614
references.citation: Neuroimage. 2008 Oct 1;42(4):1609-21
references.pmid: 18672069
references.citation: Neuropsychologia. 2010 Sep;48(11):3343-50
references.pmid: 20655319