title: Prothrombin fragment 1 + 2 (F1 + 2) in effluent is a useful marker for peritoneal permeability in peritoneal dialysis patients using neutral dialysate.
abstract: To clarify the influence of neutral dialysate (ND) on peritoneum, we examined changes in peritoneal permeability and in various markers of the coagulation and fibrinolytic system in effluent and the correlations between peritoneal permeability and those markers in peritoneal dialysis (PD) patients using ND. We evaluated 14 patients (8 men, 6 women; mean age: 58.6 +/- 12.0 years) who started PD using ND. The peritoneal equilibration test (PET) was performed to assess dialysate-to-plasma ratio for creatinine (D/P Cr) as peritoneal permeability. Coagulation markers [thrombin-antithrombin complex, fibrin monomer (FM), prothrombin fragment 1+2 (F1 + 2)] and fibrinolytic markers (fibrin degradation products, D-dimer) in effluent were also measured. At 2 years, FM in effluent was significantly lower (p = 0.006). The other markers and the D/P Cr did not change significantly. At the initiation of PD and at 2 years, D/P Cr was significantly correlated with F1 + 2 (r = 0.70 and 0.76 respectively, p < 0.01). Furthermore, multiple regression analysis showed that only F1 + 2 was correlated with D/P Cr at 2 years (r = 0.79, p = 0.004). These results suggest that ND has little influence on coagulation and fibrinolytic markers in effluent. In addition, F1 + 2 is a useful marker for peritoneal permeability in PD patients using ND.
authors.affiliation: Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, Japan. sakurada@marianna-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sakurada
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kojima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Oishi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Koitabashi
authors.forename: Masahito
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Sayuri
authors.initials: S
authors.lastname: Shirai
authors.forename: Yugo
authors.initials: Y
authors.lastname: Shibagaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D003404:Creatinine / Q000032:analysis; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis*; D010447:Peptide Hydrolases / Q000032:analysis; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D011516:Prothrombin / Q000032:analysis*
chemical_list: D015314:Dialysis Solutions; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C046193:antithrombin III-protease complex; C011468:fibrinmonomer; C045879:prothrombin fragment 1.2; D000990:Antithrombin III; D011516:Prothrombin; D003404:Creatinine; D010447:Peptide Hydrolases