title: Rosacea: The cytokine and chemokine network.
abstract: Rosacea is one of the most common dermatoses of adults. Recent studies have improved our understanding of the pathophysiology of rosacea. Current concepts suggest that known clinical trigger factors of rosacea such as UV radiation, heat, cold, stress, spicy food, and microbes modulate Toll-like receptor signaling, induce reactive oxygen species, as well as enhance antimicrobial peptide and neuropeptide production. Downstream of these events cytokines and chemokines orchestrate an inflammatory response that leads to the recruitment and activation of distinct leukocyte subsets and induces the characteristic histopathological features of rosacea. Here we summarize the current knowledge of the cytokine and chemokine network in rosacea and propose pathways that may be of therapeutic interest.
authors.affiliation: Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany.
authors.forename: Peter Arne
authors.initials: PA
authors.lastname: Gerber
authors.forename: Bettina Alexandra
authors.initials: BA
authors.lastname: Buhren
authors.forename: Martin
authors.initials: M
authors.lastname: Steinhoff
authors.forename: Bernhard
authors.initials: B
authors.lastname: Homey
mesh_terms: D000328:Adult; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D003879:Dermatologic Agents / Q000276:immunology / Q000627:therapeutic use; D066246:ErbB Receptors / Q000276:immunology / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D017382:Reactive Oxygen Species / Q000009:adverse effects / Q000276:immunology; D012393:Rosacea / Q000188:drug therapy / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D012867:Skin / Q000098:blood supply / Q000276:immunology / Q000503:physiopathology; D051193:Toll-Like Receptors / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D016207:Cytokines; D003879:Dermatologic Agents; D017382:Reactive Oxygen Species; D051193:Toll-Like Receptors; D066246:ErbB Receptors
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