title: Soft tissue surrounding switched platform implants: an immunohistochemical evaluation.
abstract: OBJECTIVE
  This clinical and immunohistochemical study was designed to characterize the cellular and molecular patterns for bone loss of soft tissues surrounding implants restored with different implant platform configurations.
  
  
  METHODS
  A total of 32 implants were restored using abutments with the following mismatches: 0 mm (control group), 0.25 mm (test group(1)), 0.5 mm (test group(2)) and 0.85 mm (test group(3)). Four years after, loading all sites were clinically healthy, and soft tissue samples were harvested and processed for immunohistochemical analysis. Amounts of lymphocytes T (LyT) -B (LyB), IL-17 and RANKL were assessed.
  
  
  RESULTS
  No significant difference was found between groups (P > 0.05) in terms of infiltrated T and B cell counts, IL-17 and RANKL expressions. When pooled data were analysed, lymphocytes T counts and IL-17 were higher than lymphocytes B counts and RANKL. LyT and LyB counts were highly negatively correlated (Pearson's r > 0.7) and IL-17 was correlated (Pearson's r > 0.4, <0.7) to LyT and LyB.
  
  
  CONCLUSIONS
  After prolonged exposure of abutments in the oral cavity, the configuration of the implant abutment interface does not seem to affect the inflammatory cellular and molecular pattern responsible for bone loss.
authors.affiliation: Department of Human Morphology and Biomedical Sciences Città Studi, Università degli Studi di Milano, Milan, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Dellavia
authors.forename: Luigi
authors.initials: L
authors.lastname: Canullo
authors.forename: Cristina
authors.initials: C
authors.lastname: Allievi
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.forename: Gaia
authors.initials: G
authors.lastname: Pellegrini
mesh_terms: D016301:Alveolar Bone Loss / Q000276:immunology* / Q000473:pathology*; D018951:Antigens, CD20 / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000276:immunology; D008297:Male; D057873:Peri-Implantitis / Q000276:immunology; D053245:RANK Ligand / Q000276:immunology; D011897:Random Allocation; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D018951:Antigens, CD20; D015921:Dental Implants; D020381:Interleukin-17; D053245:RANK Ligand