title: The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma.
abstract: OBJECTIVE
  To clarify the presence of oxidative stress in patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between oxidative stress and PACG.
  
  
  METHODS
  Fifty patients with primary angle-closure glaucoma and fifty healthy controls of matched age and gender were included in the study prospectively. Serum samples were obtained to detect the oxidation degradation products malondialdehyde (MDA), conjugated diene (CD), 4-hydroxynonenal (4-HNE), advanced oxidation protein products (AOPP), protein carbonyl (PC), ischemia-modified albumin (IMA) and 8-hydroxydeoxyguanosin (8-OHdG).
  
  
  RESULTS
  The concentration of MDA and CD in PACG patients was significantly higher than those of the control subjects (P<0.05, P<0.01). The serum 4-HNE concentrations were increased in PACG patients, but the differences with those of the healthy controls were not statistically significant. Compared to normal subjects, there was significant higher in serum AOPP and PC in PACG patients (P<0.01). PACG patients had higher levels of 8-OHdG in serum with respect to the comparative group of normal subjects (P<0.01). When plasma IMA levels in the PACG group were compared with those in the control group, significant increases in IMA were observed in the former (P<0.05).
  
  
  CONCLUSIONS
  Our study demonstrated that IMA is a new biomarker available for assessing oxidative stress in PCAG. Oxidative stress is an important risk factor in the development of primary angle-closure glaucoma. Increased levels of oxidative stress products may be associated with primary angle-closure glaucoma.
authors.affiliation: First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.forename: Qian
authors.initials: Q
authors.lastname: Sha
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhang
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Shengzhong
authors.initials: S
authors.lastname: Rong
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Pan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine / Q000031:analogs & derivatives; D000368:Aged; D000447:Aldehydes / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000097:blood* / Q000378:metabolism*; D006147:Guanine / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D000447:Aldehydes; D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D008315:Malondialdehyde; D006147:Guanine; C078307:8-oxo-7,8-dihydrodeoxyguanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; C027576:4-hydroxy-2-nonenal; D000075462:Serum Albumin, Human
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