title: Kinase inhibitors from marine sponges.
abstract: Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
authors.affiliation: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.|Centre for Medicinal Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Danielle
authors.initials: D
authors.lastname: Skropeta
authors.affiliation: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Natalie
authors.initials: N
authors.lastname: Pastro
authors.affiliation: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Ana
authors.initials: A
authors.lastname: Zivanovic
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018844:Cyclin-Dependent Kinases / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D011161:Porifera / Q000737:chemistry*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors
chemical_list: D001688:Biological Products; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D018844:Cyclin-Dependent Kinases; D020928:Mitogen-Activated Protein Kinases; D038362:Glycogen Synthase Kinase 3
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