title: GLUT4 associated proteins as therapeutic targets for diabetes.
abstract: Type 2 diabetes is a complex, multifactorial disease resulting from insulin resistance in target tissues and the impairment of insulin secretion from the pancreas. One of the key metabolic actions of insulin is to control blood sugar levels by promoting glucose uptake into adipocyte and muscle cells. This is achieved by activation of a complex signal transduction cascade that stimulates the trafficking of the insulin responsive glucose transporter protein, GLUT4, from specific intracellular sites to the plasma membrane. This review is divided into two major sections. The first section gives an overview of GLUT4 trafficking and the second section focuses on the patents that have been acquired for GLUT4 associated proteins and which demonstrate potential as therapeutic targets for the treatment of diabetes. Inventions in this area include methods and agents to translocate GLUT4 to the plasma membrane independent of insulin and methods to increase the level of GLUT4 in insulin responsive cells.
authors.affiliation: Florey Neurosciences Institutes, University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Broden J
authors.initials: BJ
authors.lastname: Morgan
authors.forename: Siew Yeen
authors.initials: SY
authors.lastname: Chai
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Albiston
mesh_terms: D010122:Cystinyl Aminopeptidase / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use*; D005786:Gene Expression Regulation / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends*; D010330:Patents as Topic; D021381:Protein Transport / Q000187:drug effects* / Q000502:physiology
chemical_list: D015507:Drugs, Investigational; D051275:Glucose Transporter Type 4; D010122:Cystinyl Aminopeptidase; C105964:leucyl-cystinyl aminopeptidase