title: [Sleep disordered breathing and nonsustained ventricular tachycardia in patients with chronic heart failure].
abstract: BACKGROUND
  Patients with chronic heart failure (CHF) have a high incidence of sleep disordered breathing (SDB). It is assumed that patients with the combination of CHF and SDB have more ventricular couplets and nonsustained ventricular tachycardia (NSVT) than patients without SDB.
  
  
  METHODS
  In 63 patients, 49 men and 14 women with chronic heart failure (EF < 45%), all-night polysomnography and long-term-ECG were performed. Mean age was 59 ± 15 years, mean BMI 27 ± 5 kg/m(2). 56% had an ischemic, 44% a nonischemic heart disease. 51% had heart insufficiency classification NYHA III.
  
  
  RESULTS
  42 of the 63 patients (67%) had sleep disordered breathing (SDB) with an AHI ≥5/h. In 24 patients (38%) SDB was central, in 18 (29%) obstructive. More patients with SDB than patients without SDB had NSVT (50% vs. 19%). Nocturnal frequency of NSVT in patients with SDB was about twice as high as the rate observed during daytime (0.48/h vs. 0.21/h). In patients without SDB there was no relevant difference between day and night (0.23/h vs. 0.21/h). AHI correlated with NSVT (r = 0.329, p < 0.01). Day/night comparison of couplets was 2.3/h vs. 1.9/h in SDB patients and 2.0/h vs. 1.6/h in patients without SDB.
  
  
  CONCLUSIONS
  Patients with chronic heart failure have a high prevalence of SDB. The combination of CHF and SDB predisposes for nocturnal malignant ventricular arrhythmias.
authors.affiliation: Klinik für Innere Medizin, SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universität Marburg, Marburg, Germany. koehleru@staff.uni-marburg.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Koehler
authors.forename: Sandra
authors.initials: S
authors.lastname: Apelt
authors.forename: Werner
authors.initials: W
authors.lastname: Cassel
authors.forename: Olaf
authors.initials: O
authors.lastname: Hildebrandt
authors.forename: Christoph
authors.initials: C
authors.lastname: Nell
authors.forename: Stephan
authors.initials: S
authors.lastname: Ranft
authors.forename: Wolfram
authors.initials: W
authors.lastname: Grimm
mesh_terms: D017677:Age Distribution; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006333:Heart Failure / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000706:statistics & numerical data; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000453:epidemiology*
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