title: [Persistent swelling after flushing of an abscess with Octenisept®].
abstract: We report the case of a long-lasting cutaneous side effect after inappropriate use of Octenisept® solution (containing octenidine and phenoxyethanol). Following lavage of an abscess in the inguinal region, a painful erythematous induration mimicking cellulitis persisted for several months. Manual lymphatic drainage considerably improved the symptoms. Octenisept® shows considerable tissue toxicity in vivo including - but not restricted to - blood vessel damage. Deterioration of endothelial cells followed by oedema and continued tissue damage can be seen histologically. Despite the fact that there is a circular letter issued by the manufacturer as well as a boxed warning on the bottles, the awareness to avoid this misuse of Octenisept® is still lacking.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinkum Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Deutschland. Bauer_B1@klinik.uni-wuerzburg.de
authors.forename: B
authors.initials: B
authors.lastname: Bauer
authors.forename: M
authors.initials: M
authors.lastname: Majic
authors.forename: S
authors.initials: S
authors.lastname: Rauthe
authors.forename: E-B
authors.initials: EB
authors.lastname: Bröcker
authors.forename: A
authors.initials: A
authors.lastname: Kerstan
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000627:therapeutic use; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D007097:Imines; D011725:Pyridines / Q000009:adverse effects* / Q000627:therapeutic use*; D007507:Therapeutic Irrigation / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; C034213:octenidine
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