title: [A case report-bleeding from the ulcer of wound for mastectomy after postoperative chemotherapy with bevacizumab for Sigmoid colon cancer].
abstract: We report the case of a 65-year-old woman with a delayed radiation ulcer and bleeding caused by bevacizumab. She has been undergoing chemotherapy for advanced colon cancer for two years. She received a mastectomy and adjuvant chemoradiotherapy for right breast cancer twenty-one years ago, and colon cancer with liver metastasis was detected using PET two years ago. Since last year she has been treated with bevacizumab chemotherapy bevacizumab due to increased liver metastases. As a result, her radiation ulcer worsened and bleeding occurred repeatedly. On suspicion of an adverse event, we stopped the bevacizumab, and that improved the radiation ulcer and the bleeding. In this case, we discussed radiation induced ulcers, wound healing, and adverse events caused by bevacizumab.
authors.affiliation: Dept. of Surgery I, Dokkyo Medical University.
authors.forename: Miyako
authors.initials: M
authors.lastname: Tsumuraya
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujita
authors.forename: Hiroto
authors.initials: H
authors.lastname: Muroi
authors.forename: Akira
authors.initials: A
authors.lastname: Sugawara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tsubaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab; D001943:Breast Neoplasms / Q000601:surgery; D059186:Chemoradiotherapy, Adjuvant; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008408:Mastectomy; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D012811:Sigmoid Neoplasms / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000473:pathology*; D014945:Wound Healing
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab