title: Bronchoscopic treatments for emphysema.
abstract: In late stage chronic obstructive pulmonary disease, emphysema can worsen respiratory symptoms, not only via the loss of surface for gas exchange, but also via alterations in mechanical properties of the respiratory system (dynamic and static hyperinflation). Emphysematous lung volume reduction aims at improving respiratory mechanics and symptomatology in patients with advanced emphysema. Lung volume reduction surgery (LVRS) has been shown to be effective in selected patient populations, but its morbidity and costs are quite elevated. Alternatives to LVRS do not remove emphysematous lung tissue per se, but rather consist of devices aiming to: 1) reduce the volume that affected lung parenchyma occupies (unidirectional endobronchial valves or plugs, parenchymal injection of bioactive scarring agents); 2) redistribute ventilatory flow (airway bypass systems). Preliminary studies of these devices have shown that they are relatively safe. These also show modest benefits in exercise capacity, although individual subjects can experience spectacular improvement. Current objective is to identify predictors of response to therapy with such devices.
authors.affiliation: Service de Pneumologie, Oncologie Thoracique et Soins Intensifs Respiratoires, Hôpital Pasteur, CHU de Nice, pavillon H, 30, avenue de la Voie-Romaine, BP 1069, 06002 Nice cedex 1, France.
authors.forename: A
authors.initials: A
authors.lastname: Delage
authors.forename: C-H
authors.initials: CH
authors.lastname: Marquette
mesh_terms: D001999:Bronchoscopy / Q000295:instrumentation / Q000379:methods*; D004864:Equipment and Supplies; D006801:Humans; D011013:Pneumonectomy / Q000295:instrumentation / Q000379:methods; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D011656:Pulmonary Emphysema / Q000601:surgery*; D015656:Respiratory Mechanics / Q000502:physiology