title: Analysis of a genome-wide association study-linked locus (CCR6) in Asian rheumatoid arthritis.
abstract: A genome-wide association study in Japan identified the C-C chemokine receptor type 6 gene (CCR6) as associated with rheumatoid arthritis (RA). This finding has not been validated in other Asian populations. A case-control study involving 996 subjects, comprising 440 controls and 556 RA patients, was done to determine their anticyclic citrullinated peptide (anti-CCP) antibody status and CCR6 polymorphism (rs3093024) genotype. Three hundred eighty-seven patients were anti-CCP positive and 153 anti-CCP negative. Logistic regression showed that allele A was likely to increase the risk of developing RA among females via a recessive model (odds ratio [OR]=1.55, 95% confidence interval [CI]=1.01, 2.39), whereas the risk effect appeared to be reduced among males via an additive model (OR=0.60, 95% CI=0.42, 0.85). Considering only subjects who are anti-CCP positive, allele A increased RA risk among females via a recessive model (OR=1.68, 95% CI=1.07, 2.64) but decreased the risk among males via an additive model (OR=0.59, 95% CI=0.39, 0.89). We showed that CCR6 polymorphism was a risk factor among females but a protective factor among males. Functional studies are warranted to unravel the pathophysiological relevance of the gene variant and other linked variants with RA.
authors.affiliation: Department of Clinical Research, Singapore General Hospital, Singapore, Singapore.
authors.forename: Esther
authors.initials: E
authors.lastname: Teng
authors.forename: Khai Pang
authors.initials: KP
authors.lastname: Leong
authors.forename: Hui Hua
authors.initials: HH
authors.lastname: Li
authors.forename: Bernard
authors.initials: B
authors.lastname: Thong
authors.forename: Ee Tzun
authors.initials: ET
authors.lastname: Koh
authors.forename: Pooi Ling
authors.initials: PL
authors.lastname: Loi
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Eng King
authors.initials: EK
authors.lastname: Tan
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D016017:Odds Ratio; D054399:Receptors, CCR6 / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C106311:CCR6 protein, human; D054399:Receptors, CCR6
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