title: Caveolin-1, cellular senescence and age-related diseases.
abstract: According to the "free radical theory" of aging, normal aging occurs as the result of tissue damages inflicted by reactive oxygen species (ROS) when ROS production exceeds the antioxidant capacity of the cell. ROS induce cellular dysfunctions such as stress-induced premature senescence (SIPS), which is believed to contribute to normal organismal aging and play a role in age-related diseases. Consistent with this hypothesis, increased oxidative damage of DNA, proteins, and lipids have been reported in aged animals and senescent cells accumulate in vivo with advancing age. Caveolin-1 acts as a scaffolding protein that concentrates and functionally regulates signaling molecules. Recently, great progress has been made toward understanding of the role of caveolin-1 in stress-induced premature senescence. Data show that caveolin-mediated signaling may contribute to explain, at the molecular level, how oxidative stress promotes the deleterious effects of cellular senescence such as aging and age-related diseases. In this review, we discuss the cellular mechanisms and functions of caveolin-1 in the context of SIPS and their relevance to the biology of aging.
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
authors.forename: Huafei
authors.initials: H
authors.lastname: Zou
authors.forename: Elena
authors.initials: E
authors.lastname: Stoppani
authors.forename: Daniela
authors.initials: D
authors.lastname: Volonte
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Galbiati
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D051242:Caveolin 1 / Q000378:metabolism*; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology*; D005355:Fibrosis; D006801:Humans; D007239:Infections / Q000209:etiology; D055959:Intervertebral Disc Degeneration / Q000209:etiology; D008954:Models, Biological; D010003:Osteoarthritis / Q000209:etiology; D018384:Oxidative Stress; D011656:Pulmonary Emphysema / Q000209:etiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D059016:Tumor Microenvironment; D014945:Wound Healing
chemical_list: D051242:Caveolin 1; D017382:Reactive Oxygen Species
references.citation: EMBO Rep. 2009 Dec;10(12):1334-40
references.pmid: 19820694
references.citation: Arthritis Res Ther. 2007;9(3):R45
references.pmid: 17498290
references.citation: Ann N Y Acad Sci. 2000 Jun;908:111-25
references.pmid: 10911952
references.citation: Spine (Phila Pa 1976). 2000 Feb 15;25(4):487-92
references.pmid: 10707396
references.citation: J Biol Chem. 1997 Jul 25;272(30):18522-5
references.pmid: 9228013
references.citation: J Gerontol. 1956 Jul;11(3):298-300
references.pmid: 13332224
references.citation: J Biol Chem. 1997 Nov 28;272(48):30429-38
references.pmid: 9374534
references.citation: Biochem Biophys Res Commun. 2002 Oct 25;298(2):203-6
references.pmid: 12387816
references.citation: Trends Mol Med. 2001 Oct;7(10):435-41
references.pmid: 11597517
references.citation: J Cell Sci. 2000 Jun;113 ( Pt 12):2103-9
references.pmid: 10825283
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Apr;56(4):B172-9
references.pmid: 11283188
references.citation: J Biol Chem. 1996 Apr 19;271(16):9690-7
references.pmid: 8621645
references.citation: Ann N Y Acad Sci. 2000;899:191-208
references.pmid: 10863540
references.citation: J Cell Sci. 2002 Jan 15;115(Pt 2):241-56
references.pmid: 11839776
references.citation: Curr Biol. 2000 Sep 21;10(18):1119-22
references.pmid: 10996792
references.citation: Cancer Res. 2009 Apr 1;69(7):2878-86
references.pmid: 19318577
references.citation: Ann Med. 2004;36(8):584-95
references.pmid: 15768830
references.citation: Cell Cycle. 2010 Aug 15;9(16):3256-76
references.pmid: 20814239
references.citation: Exp Gerontol. 2003 Nov-Dec;38(11-12):1271-83
references.pmid: 14698807
references.citation: J Gerontol. 1979 May;34(3):328-34
references.pmid: 429765
references.citation: Cell. 1997 Mar 7;88(5):593-602
references.pmid: 9054499
references.citation: Mol Cancer Res. 2009 Sep;7(9):1446-55
references.pmid: 19737975
references.citation: J Neurosci Res. 1997 Jun 15;48(6):580-7
references.pmid: 9210528
references.citation: Anat Histol Embryol. 2007 Oct;36(5):361-5
references.pmid: 17845226
references.citation: Proc Natl Acad Sci U S A. 1995 May 9;92(10):4337-41
references.pmid: 7753808
references.citation: J Cell Biol. 1994 Feb;124(3):307-13
references.pmid: 8294514
references.citation: FEBS Lett. 2009 Feb 18;583(4):597-606
references.pmid: 19167383
references.citation: Int J Biochem Cell Biol. 2002 Nov;34(11):1401-14
references.pmid: 12200035
references.citation: Proc Natl Acad Sci U S A. 1994 May 10;91(10):4130-4
references.pmid: 8183882
references.citation: Neurobiol Aging. 2004 Jul;25(6):753-9
references.pmid: 15165700
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13666-70
references.pmid: 9391083
references.citation: Science. 1994 Dec 23;266(5193):2011-5
references.pmid: 7605428
references.citation: Mech Ageing Dev. 2009 Jan-Feb;130(1-2):10-7
references.pmid: 18639575
references.citation: Am J Physiol. 1999 Sep;277(3):H1167-77
references.pmid: 10484439
references.citation: J Neurochem. 1999 Jan;72(1):120-8
references.pmid: 9886062
references.citation: J Cell Physiol. 2002 Jul;192(1):1-15
references.pmid: 12115731
references.citation: Kidney Int. 2003 Jun;63(6):2134-43
references.pmid: 12753300
references.citation: Diabetologia. 2008 Jun;51(6):1025-34
references.pmid: 18408913
references.citation: Cell. 2001 Aug 24;106(4):403-11
references.pmid: 11525727
references.citation: J Cell Biochem. 2005 Oct 15;96(3):653-64
references.pmid: 16088946
references.citation: Oncogene. 1998 Mar 5;16(9):1113-23
references.pmid: 9528853
references.citation: Science. 1998 Jan 16;279(5349):349-52
references.pmid: 9454332
references.citation: PLoS One. 2010 Dec 23;5(12):e15697
references.pmid: 21203469
references.citation: Cell. 2005 Feb 25;120(4):513-22
references.pmid: 15734683
references.citation: J Biol Chem. 1997 Feb 14;272(7):4398-403
references.pmid: 9020162
references.citation: Curr Opin Cell Biol. 2000 Dec;12(6):705-9
references.pmid: 11063935
references.citation: Nature. 2003 Jan 30;421(6922):499-506
references.pmid: 12556884
references.citation: Cell. 2008 Aug 22;134(4):657-67
references.pmid: 18724938
references.citation: Eur Respir J. 2004 Oct;24(4):575-9
references.pmid: 15459135
references.citation: Cell. 1992 Jun 26;69(7):1237-45
references.pmid: 1535557
references.citation: Nat Cell Biol. 2010 Jul;12(7):676-85
references.pmid: 20526329
references.citation: Arthritis Rheum. 2006 Mar;54(3):818-31
references.pmid: 16508959
references.citation: J Cell Biol. 1994 Jul;126(2):353-63
references.pmid: 7518463
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L865-73
references.pmid: 18192592
references.citation: FASEB J. 2008 Sep;22(9):3207-15
references.pmid: 18495757
references.citation: Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9407-11
references.pmid: 7568142
references.citation: Oncogene. 2005 Jun 2;24(24):3853-63
references.pmid: 15824742
references.citation: Cancer Biol Ther. 2008 Aug;7(8):1212-25
references.pmid: 18458534
references.citation: J Exp Med. 2006 Dec 25;203(13):2895-906
references.pmid: 17178917
references.citation: Genes Dev. 2004 Feb 1;18(3):306-19
references.pmid: 14871929
references.citation: Cell Cycle. 2011 Jun 1;10(11):1784-93
references.pmid: 21566463
references.citation: Cancer Res. 2006 Nov 15;66(22):10805-14
references.pmid: 17108117
references.citation: Exp Cell Res. 2000 Apr 10;256(1):291-9
references.pmid: 10739676
references.citation: J Biol Chem. 1996 Nov 15;271(46):29182-90
references.pmid: 8910575
references.citation: Adv Drug Deliv Rev. 2001 Jul 28;49(3):237-50
references.pmid: 11551397
references.citation: Traffic. 2003 Nov;4(11):724-38
references.pmid: 14617356
references.citation: J Biol Chem. 1996 May 17;271(20):11930-5
references.pmid: 8662667
references.citation: Am J Pathol. 2009 Jun;174(6):2023-34
references.pmid: 19411448
references.citation: Cancer Res. 1995 Jun 1;55(11):2284-92
references.pmid: 7757977
references.citation: Exp Cell Res. 1992 Aug;201(2):373-9
references.pmid: 1322316
references.citation: Int J Biochem Cell Biol. 2007;39(10):1964-74
references.pmid: 17662641
references.citation: Mech Ageing Dev. 2007 Jan;128(1):36-44
references.pmid: 17116315
references.citation: Mol Biol Cell. 1995 Jul;6(7):911-27
references.pmid: 7579702
references.citation: Annu Rev Nutr. 2001;21:453-73
references.pmid: 11375445
references.citation: Mech Ageing Dev. 2005 May;126(5):551-9
references.pmid: 15811424
references.citation: J Pathol. 1999 Jan;187(1):100-11
references.pmid: 10341711
references.citation: Arthritis Res Ther. 2008;10(4):R87
references.pmid: 18681962
references.citation: Exp Mol Med. 2006 Apr 30;38(2):126-33
references.pmid: 16672766
references.citation: Mech Ageing Dev. 2000 Sep 1;118(1-2):23-34
references.pmid: 10989122
references.citation: Mol Med. 2010 Nov-Dec;16(11-12):527-34
references.pmid: 20644900
references.citation: Nucleic Acids Res. 1995 Aug 25;23(16):3244-51
references.pmid: 7667101
references.citation: Mol Cancer Ther. 2008 Jun;7(6):1365-75
references.pmid: 18524846
references.citation: Mol Biol Cell. 2001 Aug;12(8):2229-44
references.pmid: 11514613
references.citation: J Biol Chem. 2001 Jan 26;276(4):2531-7
references.pmid: 11060295
references.citation: Science. 1990 Sep 28;249(4976):1570-4
references.pmid: 2218499
references.citation: Mech Ageing Dev. 2008 Dec;129(12):706-13
references.pmid: 18848576
references.citation: FASEB J. 2005 Feb;19(2):237-9
references.pmid: 15545301
references.citation: Cell Cycle. 2009 Dec;8(23):3984-4001
references.pmid: 19923890
references.citation: Ann N Y Acad Sci. 1999 Jun 30;874:134-7
references.pmid: 10415527
references.citation: J Biol Chem. 2004 Oct 1;279(40):42270-8
references.pmid: 15263006
references.citation: J Cell Biochem. 2009 Oct 1;108(2):519-28
references.pmid: 19626662
references.citation: Curr Med Chem. 2002 Nov;9(22):2055-75
references.pmid: 12369870
references.citation: Nature. 1997 May 15;387(6630):299-303
references.pmid: 9153396
references.citation: J Biol Chem. 2001 Jun 15;276(24):21951-9
references.pmid: 11290740
references.citation: Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7
references.pmid: 7568133
references.citation: Carcinogenesis. 2000 Mar;21(3):361-70
references.pmid: 10688856
references.citation: Mol Biol Cell. 2002 Jul;13(7):2502-17
references.pmid: 12134086
references.citation: Oncogene. 1998 Mar;16(11):1391-7
references.pmid: 9525738
references.citation: Int Immunol. 1997 Oct;9(10):1581-8
references.pmid: 9352364
references.citation: J Biol Chem. 1995 Jun 16;270(24):14399-404
references.pmid: 7782301
references.citation: Mech Ageing Dev. 2007 Nov-Dec;128(11-12):662-71
references.pmid: 18022214
references.citation: Eur Spine J. 2006 Aug;15 Suppl 3:S312-6
references.pmid: 16773379
references.citation: Int J Rheum Dis. 2009 Jul;12(2):90-9
references.pmid: 20374325
references.citation: Nature. 2002 Jan 3;415(6867):45-53
references.pmid: 11780111
references.citation: Cell Cycle. 2010 Sep 1;9(17):3515-33
references.pmid: 20855962
references.citation: Biochem J. 2000 Feb 15;346 Pt 1:1-8
references.pmid: 10657232
references.citation: J Gerontol. 1989 Nov;44(6):55-62
references.pmid: 2681364
references.citation: EMBO J. 2004 Nov 10;23(22):4451-61
references.pmid: 15510216
references.citation: Biochem J. 1998 May 15;332 ( Pt 1):43-50
references.pmid: 9576849
references.citation: Am J Respir Cell Mol Biol. 2006 Dec;35(6):681-8
references.pmid: 16840774
references.citation: Cell Cycle. 2011 Jul 1;10(13):2140-50
references.pmid: 21670602
references.citation: Science. 2006 Mar 3;311(5765):1257
references.pmid: 16456035
references.citation: J Biol Chem. 2009 Feb 27;284(9):5462-6
references.pmid: 19103597
references.citation: J Biol Chem. 1995 Jun 30;270(26):15693-701
references.pmid: 7797570
references.citation: J Biol Chem. 2003 Oct 10;278(41):39527-33
references.pmid: 12890678
references.citation: Respir Res. 2006 Feb 21;7:32
references.pmid: 16504044
references.citation: Curr Opin Cell Biol. 2003 Apr;15(2):247-54
references.pmid: 12648682
references.citation: Cell. 2000 Aug 18;102(4):407-10
references.pmid: 10966103
references.citation: EMBO J. 1998 Nov 16;17(22):6633-48
references.pmid: 9822607
references.citation: Nat Rev Cancer. 2001 Oct;1(1):46-54
references.pmid: 11900251
references.citation: Free Radic Biol Med. 2002 Nov 15;33(10):1334-46
references.pmid: 12419465
references.citation: Can J Physiol Pharmacol. 2008 Nov;86(11):761-9
references.pmid: 19011671
references.citation: J Biol Chem. 1996 Sep 13;271(37):22810-4
references.pmid: 8798458
references.citation: Ann N Y Acad Sci. 2004 Jun;1019:521-6
references.pmid: 15247079
references.citation: Genes Dev. 1998 Oct 1;12(19):2997-3007
references.pmid: 9765202
references.citation: Spine (Phila Pa 1976). 2007 Feb 1;32(3):321-7
references.pmid: 17268263
references.citation: J Biol Chem. 2000 Jul 7;275(27):20847-52
references.pmid: 10781609
references.citation: J Biol Chem. 2005 Jul 1;280(26):25134-45
references.pmid: 15802273
references.citation: FEBS Lett. 2008 May 28;582(12):1685-92
references.pmid: 18439424
references.citation: J Cell Physiol. 2001 May;187(2):226-35
references.pmid: 11268002
references.citation: J Biol Chem. 2003 Jul 25;278(30):27789-95
references.pmid: 12730243
references.citation: Exp Cell Res. 1961 Dec;25:585-621
references.pmid: 13905658
references.citation: Eur J Cancer. 1997 Apr;33(5):703-9
references.pmid: 9282108
references.citation: Mol Biol Cell. 2006 Apr;17(4):1583-92
references.pmid: 16436515
references.citation: J Cell Biol. 1992 Sep;118(5):1003-14
references.pmid: 1512286
references.citation: Proc Am Thorac Soc. 2005;2(1):50-60
references.pmid: 16113469
references.citation: J Biol Chem. 1997 Mar 7;272(10):6525-33
references.pmid: 9045678
references.citation: Aging Cell. 2010 Apr;9(2):243-51
references.pmid: 20096033
references.citation: Nature. 1990 May 31;345(6274):458-60
references.pmid: 2342578
references.citation: Exp Cell Res. 1989 Sep;184(1):138-47
references.pmid: 2551704
references.citation: J Biol Chem. 2008 Feb 15;283(7):4210-8
references.pmid: 18077459
references.citation: Trends Cell Biol. 1994 Jul;4(7):231-5
references.pmid: 14731661