title: Synthesis and antitubercular activity of novel amino acid derivatives.
abstract: In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20 μg/mL).
authors.affiliation: Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100 Manguinhos, 21041-250 Rio de Janeiro, RJ, Brazil.
authors.forename: Cristiane F
authors.initials: CF
authors.lastname: Da Costa
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Pinheiro
authors.forename: Mauro V
authors.initials: MV
authors.lastname: De Almeida
authors.forename: Maria C S
authors.initials: MC
authors.lastname: Lourenço
authors.forename: Marcus V N
authors.initials: MV
authors.lastname: De Souza
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000995:Antitubercular Agents; D006835:Hydrazones; D003523:Cycloserine