title: Willingness to participate in future HIV prevention studies among gay and bisexual men in Scotland, UK: a challenge for intervention trials.
abstract: This article examines willingness to participate in future HIV prevention research among gay and bisexual men in Scotland, UK. Anonymous, self-complete questionnaires and Orasure™ oral fluid samples were collected in commercial gay venues. 1,320 men were eligible for inclusion. 78.2% reported willingness to participate in future HIV prevention research; 64.6% for an HIV vaccine, 57.4% for a behaviour change study, and 53.0% for a rectal microbicide. In multivariate analysis, for HIV vaccine research, greater age, minority ethnicity, and not providing an oral fluid sample were associated with lower willingness; heterosexual orientation and not providing an oral fluid sample were for microbicides; higher education and greater HIV treatment optimism were for behaviour change. STI testing remained associated with being more willing to participate in microbicide research and frequent gay scene use remained associated with being more willing to participate in behaviour change research. Having an STI in the past 12 months remained significantly associated with being willing to participate in all three study types. There were no associations between sexual risk behaviour and willingness. Although most men expressed willingness to participate in future research, recruitment of high-risk men, who have the potential to benefit most, is likely to be more challenging.
authors.affiliation: MRC/CSO Social and Public Health Sciences Unit, Lilybank Gardens, Glasgow, UK. l.mcdaid@sphsu.mrc.ac.uk
authors.forename: Lisa M
authors.initials: LM
authors.lastname: McDaid
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Hart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001294:Attitude to Health; D001727:Bisexuality / Q000523:psychology* / Q000706:statistics & numerical data; D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000517:prevention & control*; D015438:Health Behavior; D018451:Homosexuality, Male / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D010358:Patient Participation / Q000523:psychology; D012107:Research Design; D012606:Scotland; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
references.citation: N Engl J Med. 2010 Dec 30;363(27):2587-99
references.pmid: 21091279
references.citation: BMJ. 2008 Sep 29;337:a1655
references.pmid: 18824488
references.citation: AIDS. 2006 Jan 9;20(2):143-57
references.pmid: 16511407
references.citation: AIDS. 2004 Nov 5;18(16):2216-7
references.pmid: 15577662
references.citation: AIDS. 2002 Jul 26;16(11):1537-44
references.pmid: 12131192
references.citation: Sex Transm Infect. 2010 Oct;86(5):404-6
references.pmid: 20595141
references.citation: AIDS Care. 2004 Jul;16(5):565-71
references.pmid: 15223525
references.citation: JAMA. 2004 Jul 14;292(2):224-36
references.pmid: 15249572
references.citation: Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001230
references.pmid: 18646068
references.citation: Sex Transm Dis. 1998 Jul;25(6):296-302
references.pmid: 9662763
references.citation: AIDS Educ Prev. 2010 Feb;22(1):28-36
references.pmid: 20166785
references.citation: N Engl J Med. 2009 Dec 3;361(23):2279-80
references.pmid: 19843556
references.citation: J Acquir Immune Defic Syndr. 2006 Jun;42(2):238-41
references.pmid: 16639347
references.citation: Lancet. 2008 Aug 23;372(9639):669-84
references.pmid: 18687459
references.citation: AIDS Care. 2008 Jan;20(1):106-15
references.pmid: 18278621
references.citation: AIDS. 2008 May 31;22(9):1063-70
references.pmid: 18520350
references.citation: Sex Transm Infect. 2005 Oct;81(5):367-72
references.pmid: 16199733
references.citation: Curr Opin Infect Dis. 2006 Feb;19(1):26-32
references.pmid: 16374214
references.citation: AIDS. 2010 Mar 13;24(5):621-35
references.pmid: 20179575
references.citation: AIDS Care. 2007 Oct;19(9):1118-27
references.pmid: 17851989
references.citation: Curr Opin Infect Dis. 2010 Feb;23(1):45-52
references.pmid: 19935420
references.citation: AIDS Care. 2002 Oct;14(5):665-74
references.pmid: 12419116
references.citation: Sex Transm Infect. 1999 Aug;75(4):242-6
references.pmid: 10615310
references.citation: Sex Transm Infect. 2009 Dec;85(7):550-4
references.pmid: 19276103
references.citation: Soc Sci Med. 2005 Jan;60(2):319-30
references.pmid: 15522488
references.citation: AIDS. 2008 Mar 12;22(5):567-74
references.pmid: 18316997
references.citation: Sex Transm Infect. 2001 Dec;77(6):427-32
references.pmid: 11714941
references.citation: BMJ. 2007 Mar 3;334(7591):455-9
references.pmid: 17332585
references.citation: Ann Epidemiol. 2009 Jun;19(6):423-31
references.pmid: 19460672
references.citation: J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):359-64
references.pmid: 15980699
references.citation: J Acquir Immune Defic Syndr. 2000 Aug 15;24(5):451-7
references.pmid: 11035616
references.citation: N Engl J Med. 2009 Dec 3;361(23):2209-20
references.pmid: 19843557
references.citation: Int J STD AIDS. 2002 Feb;13(2):102-8
references.pmid: 11839164
references.citation: AIDS. 2004 Mar 26;18(5):834-5
references.pmid: 15075529
references.citation: J Acquir Immune Defic Syndr. 2003 Apr 15;32(5):545-50
references.pmid: 12679708
references.citation: Lancet. 2007 Jul 7;370(9581):10-1
references.pmid: 17617254
references.citation: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Nov 1;16(3):195-203
references.pmid: 9390572
references.citation: J Acquir Immune Defic Syndr. 2007 Jun 1;45(2):224-30
references.pmid: 17417102