title: [The effect of changes in the level of sex hormone on prognosis of abdominal surgical systemic inflammatory response syndrome].
abstract: OBJECTIVE
  To examine if the serum level of 3 sex hormones early after admission are correlated with the prognosis in post-abdominal surgery patients with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  39 patients admitted to our surgical intensive care unit (SICU) for abdominal surgery were divided, according to their serum level of estradiol (E2), prolactin (PRL), and testosterone (TT), into: (1) E2 elevation group (n = 20), (2) E2 normal group (n = 19), (3) PRL elevation group (n = 16), (4) PRL normal group (n = 23), (5) TT reduction group (n = 14), and (6) TT normal group (n = 25), for data collection of: acute physiology and chronic health evaluation II(APACHE II) scores, total hospitalization days, ICU stay, total hospitalization cost and 28 day outcomes.
  
  
  RESULTS
  In comparison with corresponding normal group, E2 elevation group had lower (but not statistically significant) APACHE II score (11.6 ± 7.8 vs. 15.2 ± 8.8, P > 0.05), significantly shorter ICU stay (days: 8.5 ± 4.0 vs. 12.1 ± 7.9, P < 0.05), and significantly lower 28 days mortality rate (10.0% vs. 35.7%, P < 0.05); PRL elevation group had significantly shorter ICU stay (days: 8.7 ± 3.1 vs. 12.9 ± 2.1, P < 0.01), and significantly lower total hospitalization cost (thousand yuan: 6.70 ± 3.50 vs. 13.20 ± 8.20, P < 0.05); TT reduction group had significantly lower APACHE II score (10.4 ± 5.4 vs. 15.2 ± 9.4, P < 0.05), significantly shorter ICU stay (days: 26.6 ± 12.2 vs. 28.1 ± 17.0, P < 0.01), and significantly lower 28-day mortality rate (0 vs. 31.8%, P < 0.01).
  
  
  CONCLUSIONS
  The early serum levels of sex hormones may have significant influence on the prognosis in post-abdominal surgery patients with SIRS.
authors.affiliation: Tianjin Medical University, Department of Surgical Intensive Care Unit, Tianjin, China.
authors.forename: Chuan-yong
authors.initials: CY
authors.lastname: Gong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Chao
authors.initials: C
authors.lastname: Du
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D011379:Prognosis; D011388:Prolactin / Q000097:blood; D011446:Prospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000175:diagnosis*; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin