title: aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle.
abstract: aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India. srivaric@iict.res.in
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: Sreerangam N C V L
authors.initials: SN
authors.lastname: Pushpavalli
authors.forename: Srinivas
authors.initials: S
authors.lastname: Chatla
authors.forename: Debasmita
authors.initials: D
authors.lastname: Mukhopadhyay
authors.forename: Bogonda
authors.initials: B
authors.lastname: Ganganna
authors.forename: Kandi
authors.initials: K
authors.lastname: Vijeender
authors.forename: Pabbaraja
authors.initials: P
authors.lastname: Srihari
authors.forename: Chada Raji
authors.initials: CR
authors.lastname: Reddy
authors.forename: M
authors.initials: M
authors.lastname: Janaki Ramaiah
authors.forename: Utpal
authors.initials: U
authors.lastname: Bhadra
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004331:Drosophila melanogaster / Q000378:metabolism*; D015195:Drug Design; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy*; D013045:Species Specificity
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones; D035683:MicroRNAs; D049452:Green Fluorescent Proteins