title: Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study.
abstract: Bangladesh has high well water arsenic exposure. Chronic arsenic ingestion may result in diseases that manifest as dyspnoea, although information is sparse. Baseline values were obtained from an arsenic study. Trained physicians ascertained data on dyspnoea among 11,746 subjects. Data were collected on demographic factors, including smoking, blood pressure and arsenic exposure. Logistic regression models estimated odds ratios and confidence intervals for the association between arsenic exposure and dyspnoea. The adjusted odds of having dyspnoea was 1.32-fold (95% CI 1.15-1.52) greater in those exposed to high well water arsenic concentrations (≥ 50 μg · L(-1)) compared with low-arsenic-exposed nonsmokers (p<0.01). A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea. In nonsmokers, the adjusted odds of having dyspnoea were 1.36, 1.96, 2.34 and 1.80-fold greater for arsenic concentrations of 7-38, 39-90, 91-178 and 179-864 μg · L(-1), respectively, compared with the reference arsenic concentration of <7 μg · L(-1) (p<0.01; Chi-squared test for trend). Arsenic exposure through well water is associated with dyspnoea, independently of smoking status. This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Harlem Hospital, Columbia University, New York, NY 10037, USA. grp4@columbia.edu
authors.forename: Gene R
authors.initials: GR
authors.lastname: Pesola
authors.forename: Faruque
authors.initials: F
authors.lastname: Parvez
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Alauddin
authors.initials: A
authors.lastname: Ahmed
authors.forename: Rabiul
authors.initials: R
authors.lastname: Hasan
authors.forename: Habibul
authors.initials: H
authors.lastname: Ahsan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000633:toxicity*; D001459:Bangladesh / Q000453:epidemiology; D060766:Drinking Water / Q000737:chemistry*; D004417:Dyspnea / Q000139:chemically induced* / Q000453:epidemiology*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D055815:Young Adult
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic
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