title: Phosphodiesterase I-inhibiting Diels-Alder adducts from the leaves of Morus mesozygia.
abstract: A new 2-arylbenzofuran derivative, (+)-dimethylsmoracin O (1), and three new Diels-Alder type adducts, mesozygins A–C (2–4), in addition to eight known compounds, artonin I (5), chalcomaracin (6), norartocarpetin (7), moracin L (8), mulberrofuran F (9), moracin M (10), moracin C (11), and morachalcone A (12),were isolated from the leaves of Morus mesozygia Stapf. Structures were elucidated by spectroscopic data analyses. Compounds 2-7 displayed a potent phosphodiesterase I inhibitory activity.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
authors.forename: Christian D A
authors.initials: CD
authors.lastname: Fozing
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Gilbert D W F
authors.initials: GD
authors.lastname: Kapche
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D043264:Phosphodiesterase I / Q000037:antagonists & inhibitors*; D010726:Phosphodiesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D012910:Snake Venoms / Q000737:chemistry; D012911:Snakes
chemical_list: D001572:Benzofurans; D010726:Phosphodiesterase Inhibitors; D010936:Plant Extracts; D012910:Snake Venoms; D043264:Phosphodiesterase I