title: Preliminary evaluation of Raboral V-RG® oral rabies vaccine in Arctic foxes (Vulpes lagopus).
abstract: We tested the Raboral V-RG® recombinant oral rabies vaccine for its response in Arctic foxes (Vulpes lagopus), the reservoir of rabies virus in the circumpolar North. The vaccine, which is currently the only licensed oral rabies vaccine in the United States, induced a strong antibody response and protected foxes against a challenge of 500,000 mouse intracerebral lethal dose 50% of an Arctic rabies virus variant. However, one unvaccinated control fox survived challenge with rabies virus, either indicating a high resistance of Arctic foxes to rabies infection or a previous exposure that induced immunity. This preliminary study suggested that Raboral V-RG vaccine may be efficacious in Arctic foxes.
authors.affiliation: Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks, 902 North Koyukuk Dr. Irving1 #311, Fairbanks, Alaska 99775, USA.
authors.forename: Erich
authors.initials: E
authors.lastname: Follmann
authors.forename: Don
authors.initials: D
authors.lastname: Ritter
authors.forename: Rhonda
authors.initials: R
authors.lastname: Swor
authors.forename: Mike
authors.initials: M
authors.lastname: Dunbar
authors.forename: Karsten
authors.initials: K
authors.lastname: Hueffer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018562:Disease Transmission, Infectious / Q000517:prevention & control / Q000662:veterinary; D005260:Female; D005589:Foxes / Q000276:immunology / Q000821:virology; D008297:Male; D011818:Rabies / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: D011819:Rabies Vaccines; D014614:Vaccines, Synthetic
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