title: Cell delivery of therapeutic nanoparticles.
abstract: Nanomedicine seeks to manufacture drugs and other biologically relevant molecules that are packaged into nanoscale systems for improved delivery. This includes known drugs, proteins, enzymes, and antibodies that have limited clinical efficacy based on delivery, circulating half-lives, or toxicity profiles. The <100 nm nanoscale physical properties afford them a unique biologic potential for biomedical applications. Hence they are attractive systems for treatment of cancer, heart and lung, blood, inflammatory, and infectious diseases. Proposed clinical applications include tissue regeneration, cochlear and retinal implants, cartilage and joint repair, skin regeneration, antimicrobial therapy, correction of metabolic disorders, and targeted drug delivery to diseased sites including the central nervous system. The potential for cell and immune side effects has necessitated new methods for determining formulation toxicities. To realize the potential of nanomedicine from the bench to the patient bedside, our laboratories have embarked on developing cell-based carriage of drug nanoparticles to improve clinical outcomes in infectious and degenerative diseases. The past half decade has seen the development and use of cells of mononuclear phagocyte lineage, including dendritic cells, monocytes, and macrophages, as Trojan horses for carriage of anti-inflammatory and anti-infective medicines. The promise of this new technology and the perils in translating it for clinical use are developed and discussed in this chapter.
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, Omaha, NE, USA.
authors.forename: JoEllyn
authors.initials: J
authors.lastname: McMillan
authors.forename: Elena
authors.initials: E
authors.lastname: Batrakova
authors.forename: Howard E
authors.initials: HE
authors.lastname: Gendelman
mesh_terms: D000818:Animals; D002477:Cells / Q000378:metabolism*; D004194:Disease; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000295:instrumentation; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines
references.citation: Nanomedicine. 2011 Apr;7(2):242-7
references.pmid: 20692375
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2199-204
references.pmid: 11854516
references.citation: Neurosci Lett. 2009 May 22;455(3):187-90
references.pmid: 19429118
references.citation: Biochim Biophys Acta. 1996 Jan 12;1278(1):59-67
references.pmid: 8611608
references.citation: Curr Opin Biotechnol. 2007 Dec;18(6):565-71
references.pmid: 18160274
references.citation: J Biol Chem. 1990 Mar 25;265(9):5226-31
references.pmid: 2318890
references.citation: Breast Cancer Res Treat. 2007 Oct;105(2):157-67
references.pmid: 17221158
references.citation: Neurosurgery. 2003 Sep;53(3):697-702; discussion 702-3
references.pmid: 12943585
references.citation: Nanomedicine. 2011 Dec;7(6):797-805
references.pmid: 21419872
references.citation: Biochemistry. 1998 Sep 15;37(37):12875-83
references.pmid: 9737866
references.citation: Nat Nanotechnol. 2007 Sep;2(9):535-6
references.pmid: 18654361
references.citation: Toxicology. 2011 May 10;283(2-3):65-87
references.pmid: 21414382
references.citation: J Control Release. 2011 Mar 10;150(2):204-11
references.pmid: 21108978
references.citation: Int J Pharm. 2011 Feb 14;404(1-2):180-90
references.pmid: 21087660
references.citation: AJR Am J Roentgenol. 1995 May;164(5):1147-52
references.pmid: 7717222
references.citation: Cancer Chemother Pharmacol. 2008 Jan;61(1):133-44
references.pmid: 17393166
references.citation: Eur J Neurosci. 1996 Apr;8(4):727-35
references.pmid: 9081624
references.citation: Curr Pharm Biotechnol. 2005 Feb;6(1):3-5
references.pmid: 15727551
references.citation: Curr Drug Deliv. 2011 Jan;8(1):59-69
references.pmid: 21034421
references.citation: Pharm Res. 2003 Feb;20(2):221-8
references.pmid: 12636160
references.citation: Int J Nanomedicine. 2007;2(1):3-7
references.pmid: 17722505
references.citation: Nat Rev Microbiol. 2010 Nov;8(11):827-34
references.pmid: 20938454
references.citation: Prog Neurobiol. 2009 Feb;87(3):133-70
references.pmid: 18926873
references.citation: Nanomedicine (Lond). 2007 Dec;2(6):789-803
references.pmid: 18095846
references.citation: Nano Lett. 2005 Apr;5(4):709-11
references.pmid: 15826113
references.citation: Cell Res. 2003 Dec;13(6):503-7
references.pmid: 14728808
references.citation: Biochim Biophys Acta. 1992 Jan 31;1103(2):185-97
references.pmid: 1543703
references.citation: Occup Environ Med. 2007 Sep;64(9):609-15
references.pmid: 17409182
references.citation: Nanomedicine (Lond). 2009 Dec;4(8):951-66
references.pmid: 19958231
references.citation: Anal Biochem. 2004 Jan 1;324(1):60-7
references.pmid: 14654046
references.citation: Nature. 2001 Apr 5;410(6829):701-5
references.pmid: 11287958
references.citation: Cancer Lett. 2004 Jun 25;209(2):171-6
references.pmid: 15159019
references.citation: Expert Opin Pharmacother. 2006 Jun;7(8):1041-53
references.pmid: 16722814
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11613-8
references.pmid: 18697944
references.citation: Trends Immunol. 2006 Dec;27(12):573-9
references.pmid: 17049307
references.citation: Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502
references.pmid: 16407415
references.citation: Int J Pharm. 2010 Nov 15;400(1-2):194-200
references.pmid: 20801205
references.citation: Occup Environ Med. 2004 Sep;61(9):727-8
references.pmid: 15317911
references.citation: Nanomedicine. 2010 Oct;6(5):651-61
references.pmid: 20348031
references.citation: Cancer Res. 2003 Sep 15;63(18):5838-43
references.pmid: 14522907
references.citation: Drugs. 2009;69(3):361-92
references.pmid: 19275278
references.citation: Nat Rev Neurosci. 2006 Jan;7(1):75-84
references.pmid: 16371952
references.citation: Transplantation. 2001 Dec 27;72(12 Suppl):S105-12
references.pmid: 11833142
references.citation: Drug Discov Today. 2010 Oct;15(19-20):842-50
references.pmid: 20727417
references.citation: Biomacromolecules. 2007 Mar;8(3):998-1003
references.pmid: 17274654
references.citation: Biomaterials. 2011 Jan;32(2):387-94
references.pmid: 20880575
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10211-6
references.pmid: 17553967
references.citation: Mol Pharm. 2008 May-Jun;5(3):449-63
references.pmid: 18393438
references.citation: J Control Release. 2008 Aug 25;130(1):64-8
references.pmid: 18582980
references.citation: Virulence. 2010 Mar-Apr;1(2):62-7
references.pmid: 21178416
references.citation: Methods Mol Biol. 2010;610:123-44
references.pmid: 20013176
references.citation: J Nanosci Nanotechnol. 2005 Oct;5(10):1688-93
references.pmid: 16245529
references.citation: Eur J Pharm Biopharm. 2008 Feb;68(2):153-68
references.pmid: 17869074
references.citation: Pharm Res. 2011 Feb;28(2):200-14
references.pmid: 20821040
references.citation: J Am Chem Soc. 2008 Nov 19;130(46):15437-43
references.pmid: 18954050
references.citation: Med Mycol. 2011 Aug;49(6):561-80
references.pmid: 21366509
references.citation: J Nanosci Nanotechnol. 2010 Dec;10(12):7906-18
references.pmid: 21121278
references.citation: Biomaterials. 2010 Nov;31(32):8393-401
references.pmid: 20688391
references.citation: Blood. 2006 Oct 15;108(8):2827-35
references.pmid: 16809617
references.citation: Crit Rev Ther Drug Carrier Syst. 2003;20(5):357-403
references.pmid: 14959789
references.citation: Adv Drug Deliv Rev. 2010 Feb 17;62(2):258-71
references.pmid: 19909776
references.citation: J Biomed Mater Res A. 2009 Apr;89(1):24-35
references.pmid: 18404707
references.citation: J Control Release. 2011 Jun 10;152(2):310-6
references.pmid: 21402114
references.citation: Science. 2008 Aug 29;321(5893):1218-21
references.pmid: 18669821
references.citation: Nature. 2005 Jul 28;436(7050):568-72
references.pmid: 16049491
references.citation: Mol Pharm. 2010 Jun 7;7(3):763-74
references.pmid: 20230026
references.citation: Science. 2006 Feb 3;311(5761):622-7
references.pmid: 16456071
references.citation: J Proteome Res. 2010 Dec 3;9(12):6759-73
references.pmid: 20954747
references.citation: Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):487-503
references.pmid: 16863457
references.citation: Environ Health Perspect. 2006 Feb;114(2):165-72
references.pmid: 16451849
references.citation: Acta Biomater. 2011 May;7(5):2185-99
references.pmid: 21284960
references.citation: J Natl Cancer Inst. 2004 Nov 3;96(21):1593-603
references.pmid: 15523088
references.citation: Nano Lett. 2006 Aug;6(8):1682-6
references.pmid: 16895356
references.citation: Eur J Pharm Biopharm. 2008 Sep;70(1):98-108
references.pmid: 18501572
references.citation: J Magn Reson Imaging. 2001 Oct;14(4):355-61
references.pmid: 11599058
references.citation: J Drug Target. 2006 Sep;14(8):546-56
references.pmid: 17050121
references.citation: Biomacromolecules. 2005 Sep-Oct;6(5):2726-31
references.pmid: 16153112
references.citation: Anal Chem. 2011 Mar 15;83(6):2125-32
references.pmid: 21351748
references.citation: Nanoscale. 2010 Jan;2(1):60-8
references.pmid: 20648364
references.citation: Nanomedicine. 2010 Aug;6(4):523-9
references.pmid: 20085824
references.citation: Bioconjug Chem. 2007 Mar-Apr;18(2):403-9
references.pmid: 17284011
references.citation: Biomaterials. 2008 Apr;29(12):1912-9
references.pmid: 18242692
references.citation: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10344-9
references.pmid: 11504914
references.citation: Sci Transl Med. 2011 Mar 23;3(75):75cm8
references.pmid: 21430266
references.citation: Microbes Infect. 2011 Feb;13(2):134-42
references.pmid: 21034846
references.citation: Cell Microbiol. 2000 Oct;2(5):379-86
references.pmid: 11207593
references.citation: J Gene Med. 2011 Mar;13(3):158-70
references.pmid: 21344542
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12897-902
references.pmid: 19620717
references.citation: Clin Pharmacol Ther. 2008 May;83(5):761-9
references.pmid: 17957183
references.citation: Biomed Microdevices. 2008 Oct;10(5):693-700
references.pmid: 18350380
references.citation: Nat Nanotechnol. 2007 Nov;2(11):713-7
references.pmid: 18654411
references.citation: Am J Sports Med. 2011 Jun;39(6):1180-90
references.pmid: 21310939
references.citation: Nanomedicine (Lond). 2006 Aug;1(2):235-49
references.pmid: 17716113
references.citation: Mol Cancer Ther. 2008 Dec;7(12):3878-88
references.pmid: 19074860
references.citation: Adv Drug Deliv Rev. 2004 Sep 22;56(11):1649-59
references.pmid: 15350294
references.citation: Proteomics. 2009 Jan;9(1):205-9
references.pmid: 19053139
references.citation: Stem Cells. 2009 Sep;27(9):2320-30
references.pmid: 19544410
references.citation: Cancer. 2006 Aug 1;107(3):459-66
references.pmid: 16795065
references.citation: Cancer Res. 2005 Apr 15;65(8):3307-18
references.pmid: 15833864
references.citation: Nat Med. 2010 Sep;16(9):1035-41
references.pmid: 20711198
references.citation: Chem Soc Rev. 2004 Jan 10;33(1):43-63
references.pmid: 14737508
references.citation: Cancer Res. 2006 Sep 1;66(17):8740-8
references.pmid: 16951190
references.citation: Curr Mol Med. 2010 Oct;10(7):640-52
references.pmid: 20712588
references.citation: Cancer Res. 1996 Oct 15;56(20):4625-9
references.pmid: 8840975
references.citation: Cell. 1993 Nov 5;75(3):409-18
references.pmid: 8221884
references.citation: Colloids Surf B Biointerfaces. 2008 Oct 15;66(2):274-80
references.pmid: 18722754
references.citation: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Jul-Aug;1(4):405-14
references.pmid: 20049806
references.citation: Acta Physiol Hung. 2010 Sep;97(3):247-55
references.pmid: 20843763
references.citation: Environ Health Perspect. 2005 Nov;113(11):1555-60
references.pmid: 16263511
references.citation: Toxicol Appl Pharmacol. 2007 Jun 15;221(3):339-48
references.pmid: 17482224
references.citation: Nano Lett. 2006 Dec;6(12):2826-32
references.pmid: 17163713
references.citation: Biomol Eng. 2006 Sep;23(4):171-84
references.pmid: 16843058
references.citation: Nat Biotechnol. 2007 Oct;25(10):1159-64
references.pmid: 17873867
references.citation: Adv Mater. 2009;21:419-424
references.pmid: 19606281
references.citation: Nanomedicine (Lond). 2011 Jan;6(1):25-42
references.pmid: 21182416
references.citation: J Pharm Bioallied Sci. 2010 Oct;2(4):282-9
references.pmid: 21180459
references.citation: Cancer Res. 1987 Aug 1;47(15):4202-7
references.pmid: 3496957
references.citation: Mol Ther. 2010 Feb;18(2):370-6
references.pmid: 19997090
references.citation: Pharmacol Ther. 2009 Feb;121(2):192-204
references.pmid: 19103221
references.citation: Toxicol Sci. 2008 Nov;106(1):140-52
references.pmid: 18632727
references.citation: Biochem Biophys Res Commun. 2005 Jul 15;332(4):1053-60
references.pmid: 15922303
references.citation: Science. 2004 Mar 19;303(5665):1818-22
references.pmid: 15031496
references.citation: Cancer Res. 2002 Jul 1;62(13):3603-8
references.pmid: 12097260
references.citation: Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9
references.pmid: 7882925
references.citation: Immunol Lett. 2010 Jan 18;128(1):29-35
references.pmid: 19895847
references.citation: Toxicol Appl Pharmacol. 2008 May 15;229(1):121-34
references.pmid: 18355886
references.citation: Pharmacol Rev. 2001 Jun;53(2):283-318
references.pmid: 11356986
references.citation: Arch Toxicol. 2011 Jul;85(7):733-41
references.pmid: 20502881
references.citation: Circulation. 2003 Nov 4;108(18):2270-4
references.pmid: 14557370
references.citation: Folia Neuropathol. 2010;48(4):231-7
references.pmid: 21225505
references.citation: Adv Drug Deliv Rev. 2009 Jun 21;61(6):422-7
references.pmid: 19389437
references.citation: Int J Nanomedicine. 2010 Oct 21;5:853-60
references.pmid: 21042547
references.citation: J Control Release. 2005 Jun 20;105(1-2):68-76
references.pmid: 15955367
references.citation: J Control Release. 2011 Aug 10;153(3):255-61
references.pmid: 21295089
references.citation: Nat Biotechnol. 2003 Jan;21(1):47-51
references.pmid: 12459736
references.citation: Curr Eye Res. 2010 Dec;35(12):1081-9
references.pmid: 20961207
references.citation: J Control Release. 2010 Dec 20;148(3):380-7
references.pmid: 20869412
references.citation: Nature. 2011 Feb 24;470(7335):543-7
references.pmid: 21350488
references.citation: Crit Rev Toxicol. 2009;39(7):613-26
references.pmid: 19650720
references.citation: Expert Opin Drug Deliv. 2011 Apr;8(4):415-33
references.pmid: 21348773
references.citation: Biomaterials. 2010 Jan;31(1):91-8
references.pmid: 19783039
references.citation: Annu Rev Pharmacol Toxicol. 2010;50:63-88
references.pmid: 20055698
references.citation: Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4 Suppl):3-10
references.pmid: 17291399
references.citation: Radiology. 2007 Nov;245(2):333-56
references.pmid: 17940297
references.citation: Nat Biotechnol. 2006 Oct;24(10):1211-7
references.pmid: 17033654
references.citation: Int J Nanomedicine. 2009;4:261-75
references.pmid: 20011243
references.citation: Pharm Res. 2002 Sep;19(9):1310-6
references.pmid: 12403067
references.citation: Biomaterials. 2010 Apr;31(10):2874-81
references.pmid: 20044131
references.citation: Drug Metab Dispos. 2008 Aug;36(8):1709-15
references.pmid: 18490436
references.citation: Eur J Pharm Biopharm. 2008 Jan;68(1):112-28
references.pmid: 17804211
references.citation: PLoS One. 2009;4(2):e4343
references.pmid: 19183814
references.citation: Science. 2000 Nov 24;290(5496):1526-7
references.pmid: 11185512
references.citation: Stem Cells. 2008 Mar;26(3):831-41
references.pmid: 18192232
references.citation: Nature. 2008 Sep 4;455(7209):58-63
references.pmid: 18668040
references.citation: Toxicol Sci. 2011 Mar;120 Suppl 1:S109-29
references.pmid: 21177774
references.citation: Biomaterials. 2008 Jan;29(2):238-46
references.pmid: 17935779
references.citation: J Control Release. 2011 Jan 20;149(2):159-67
references.pmid: 20950659
references.citation: Clin Exp Allergy. 2004 Feb;34(2):315-21
references.pmid: 14987314
references.citation: J Antimicrob Chemother. 2008 Aug;62(2):376-80
references.pmid: 18453526
references.citation: Biomaterials. 2011 Mar;32(9):2274-84
references.pmid: 21193228
references.citation: J Chem Phys. 2009 Apr 14;130(14):144902
references.pmid: 19368466
references.citation: Blood. 2009 Sep 17;114(12):2417-26
references.pmid: 19605850
references.citation: J Nanosci Nanotechnol. 2010 Dec;10(12):7919-30
references.pmid: 21121279
references.citation: Environ Mol Mutagen. 2009 Oct;50(8):708-17
references.pmid: 19774611
references.citation: Methods Mol Biol. 2011;726:95-110
references.pmid: 21424445
references.citation: Nat Biotechnol. 2003 Jan;21(1):41-6
references.pmid: 12459735
references.citation: Curr Opin Biotechnol. 2007 Feb;18(1):26-30
references.pmid: 17254762
references.citation: J Virol. 2007 Mar;81(6):2700-12
references.pmid: 17182671
references.citation: Biochem Biophys Res Commun. 1975 Apr 7;63(3):651-8
references.pmid: 1131256
references.citation: Int J Nanomedicine. 2010 Aug 09;5:533-47
references.pmid: 20957115
references.citation: Adv Drug Deliv Rev. 2010 Aug 30;62(11):1005-22
references.pmid: 20851156
references.citation: Nanomedicine (Lond). 2009 Dec;4(8):903-17
references.pmid: 19958227
references.citation: Eur J Pharm Biopharm. 2005 Feb;59(2):263-72
references.pmid: 15661498
references.citation: Curr Clin Pharmacol. 2010 Nov;5(4):257-80
references.pmid: 20925643
references.citation: Int J Pharm. 2003 Aug 11;261(1-2):43-55
references.pmid: 12878394
references.citation: Int J Nanomedicine. 2011 Jan 06;6:77-84
references.pmid: 21289984
references.citation: Trends Biochem Sci. 1992 Apr;17(4):141-6
references.pmid: 1585457
references.citation: Small. 2007 Nov;3(11):1941-9
references.pmid: 17963284
references.citation: Magn Reson Med. 2005 Mar;53(3):621-7
references.pmid: 15723405
references.citation: Small. 2005 Mar;1(3):325-7
references.pmid: 17193451
references.citation: Langmuir. 2011 Apr 5;27(7):3703-12
references.pmid: 21361304
references.citation: J Neuroimmune Pharmacol. 2010 Dec;5(4):592-601
references.pmid: 20237859
references.citation: Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):394-407
references.pmid: 19931581
references.citation: J Immunol. 2009 Jul 1;183(1):661-9
references.pmid: 19535632
references.citation: Environ Health Perspect. 2005 Jul;113(7):823-39
references.pmid: 16002369
references.citation: Nanomedicine (Lond). 2010 Oct;5(8):1237-60
references.pmid: 21039200
references.citation: Virology. 2007 Feb 5;358(1):148-58
references.pmid: 16997345
references.citation: Biomaterials. 2007 Jul;28(21):3217-27
references.pmid: 17445882
references.citation: Bioconjug Chem. 2006 Sep-Oct;17(5):1109-15
references.pmid: 16984117
references.citation: Biochem Biophys Res Commun. 2004 Feb 6;314(2):529-34
references.pmid: 14733939
references.citation: Ann Biomed Eng. 2006 Jan;34(1):23-38
references.pmid: 16496086
references.citation: Mol Biosyst. 2010 Oct;6(10):1813-20
references.pmid: 20697616
references.citation: Nanotechnology. 2010 Oct 8;21(40):405101
references.pmid: 20823498
references.citation: Biomaterials. 2011 Jan;32(1):28-38
references.pmid: 20875915
references.citation: Expert Opin Biol Ther. 2009 Apr;9(4):427-40
references.pmid: 19344280
references.citation: Toxicol Sci. 2008 Feb;101(2):239-53
references.pmid: 17872897
references.citation: Adv Mater. 2011 Mar 25;23(12):H18-40
references.pmid: 21433100
references.citation: Biochem Biophys Res Commun. 2003 Mar 14;302(3):496-501
references.pmid: 12615061
references.citation: Anal Bioanal Chem. 2011 Apr;400(2):483-92
references.pmid: 21373833
references.citation: J Neuroimmune Pharmacol. 2006 Sep;1(3):340-50
references.pmid: 18040810
references.citation: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15256-61
references.pmid: 10611372
references.citation: Chem Pharm Bull (Tokyo). 2011;59(2):272-8
references.pmid: 21297311
references.citation: Nano Lett. 2011 Feb 9;11(2):814-9
references.pmid: 21210706
references.citation: Eur J Pharm Biopharm. 2007 Mar;65(3):270-81
references.pmid: 17027243
references.citation: Int J Pharm. 2008 Feb 28;350(1-2):312-9
references.pmid: 17897801
references.citation: J Microencapsul. 2011;28(2):134-41
references.pmid: 21142697
references.citation: ACS Nano. 2008 Aug;2(8):1639-44
references.pmid: 19206367
references.citation: Science. 1994 Mar 18;263(5153):1600-3
references.pmid: 8128245
references.citation: Nano Lett. 2007 Nov;7(11):3452-61
references.pmid: 17949046
references.citation: Pharm Res. 2011 Feb;28(2):215-36
references.pmid: 20721603
references.citation: Int J Pharm. 2007 Feb 1;329(1-2):192-8
references.pmid: 17005341
references.citation: J Neuroimmune Pharmacol. 2012 Mar;7(1):279-88
references.pmid: 21431472
references.citation: FASEB J. 2005 Mar;19(3):311-30
references.pmid: 15746175
references.citation: Pharm Res. 2008 Jul;25(7):1521-30
references.pmid: 18172580
references.citation: Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):547-59
references.pmid: 19914315
references.citation: J Am Chem Soc. 2009 Jan 21;131(2):406-7
references.pmid: 19105654
references.citation: Methods. 2006 Sep;40(1):86-97
references.pmid: 16997717
references.citation: Biomaterials. 2011 Mar;32(8):2106-16
references.pmid: 21183214
references.citation: J Neurosci. 2004 Nov 3;24(44):9799-810
references.pmid: 15525765
references.citation: Nanotoxicology. 2011 Mar;5(1):66-78
references.pmid: 21417689
references.citation: Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):560-75
references.pmid: 19914313
references.citation: J Am Chem Soc. 2009 Jul 8;131(26):9311-20
references.pmid: 19527027
references.citation: J Chemother. 2004 Nov;16 Suppl 4:94-7
references.pmid: 15688621
references.citation: Pharm Res. 2011 Jul;28(7):1631-42
references.pmid: 21374102
references.citation: Curr Cancer Drug Targets. 2011 Feb;11(2):135-46
references.pmid: 21158724
references.citation: J Immunol. 2011 Apr 1;186(7):4422-32
references.pmid: 21357545
references.citation: ACS Nano. 2010 Sep 28;4(9):5321-31
references.pmid: 20690607
references.citation: Nanomedicine. 2011 Aug;7(4):489-96
references.pmid: 21215329
references.citation: Nanomedicine (Lond). 2011 Aug;6(6):975-94
references.pmid: 21417829
references.citation: J Neurosci. 2011 Mar 2;31(9):3148-57
references.pmid: 21368026
references.citation: Cancer Res. 1994 Feb 15;54(4):987-92
references.pmid: 8313389
references.citation: Nat Biotechnol. 2004 Aug;22(8):969-76
references.pmid: 15258594
references.citation: J Pathol. 2000 Oct;192(2):150-8
references.pmid: 11004690
references.citation: Nanomedicine (Lond). 2010 Apr;5(3):379-96
references.pmid: 20394532
references.citation: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun;2(3):205-18
references.pmid: 20391461
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1858-63
references.pmid: 9465107
references.citation: Nanomedicine. 2011 Aug;7(4):497-504
references.pmid: 21272666
references.citation: Nat Biotechnol. 2009 Mar;27(3):213-4
references.pmid: 19270655
references.citation: Biomaterials. 2011 Apr;32(11):2894-906
references.pmid: 21256584
references.citation: Bioconjug Chem. 2007 Sep-Oct;18(5):1498-506
references.pmid: 17760417
references.citation: Science. 2009 Apr 3;324(5923):59-63
references.pmid: 19342581
references.citation: Nat Rev Mol Cell Biol. 2003 May;4(5):385-96
references.pmid: 12728272
references.citation: Nanomedicine. 2005 Sep;1(3):193-212
references.pmid: 17292079
references.citation: Eur J Radiol. 2011 Dec;80(3):699-705
references.pmid: 20810233
references.citation: Chem Biol. 2005 Jan;12(1):5-6
references.pmid: 15664507
references.citation: ACS Nano. 2010 Feb 23;4(2):625-31
references.pmid: 20121215
references.citation: Biomaterials. 2007 Nov;28(31):4717-32
references.pmid: 17686516
references.citation: Toxicol Lett. 2006 Aug 1;165(1):88-100
references.pmid: 16527436
references.citation: Biomaterials. 2008 May;29(15):2378-87
references.pmid: 18313139
references.citation: Int J Nanomedicine. 2009;4:217-25
references.pmid: 19918368
references.citation: ACS Nano. 2010 Mar 23;4(3):1493-500
references.pmid: 20201555
references.citation: Nano Lett. 2006 Apr;6(4):662-8
references.pmid: 16608261
references.citation: Pharm Res. 2011 Apr;28(4):776-87
references.pmid: 21132352
references.citation: Photochem Photobiol. 2003 Jun;77(6):638-44
references.pmid: 12870850
references.citation: Virology. 2010 Dec 5;408(1):80-8
references.pmid: 20880566
references.citation: Pharm Res. 2009 Jun;26(6):1324-31
references.pmid: 19214716
references.citation: Immunology. 2001 Jan;102(1):2-7
references.pmid: 11168630
references.citation: J Antimicrob Chemother. 2004 Jul;54(1):60-8
references.pmid: 15163652