title: Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats.
abstract: Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats. Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days. Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.
authors.affiliation: Pharmacology Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India.
authors.forename: Gulam Mohammed
authors.initials: GM
authors.lastname: Husain
authors.forename: Shyam Sunder
authors.initials: SS
authors.lastname: Chatterjee
authors.forename: Paras Nath
authors.initials: PN
authors.lastname: Singh
authors.forename: Vikas
authors.initials: V
authors.lastname: Kumar
references.citation: Metabolism. 1980 Oct;29(10):970-3
references.pmid: 6999292
references.citation: Drug Discov Ther. 2009 Oct;3(5):215-20
references.pmid: 22495631
references.citation: Indian J Exp Biol. 1999 Dec;37(12):1171-6
references.pmid: 10865882
references.citation: Int J Biochem Cell Biol. 2008;40(8):1509-21
references.pmid: 18226577
references.citation: Clin Chem. 1972 Jun;18(6):499-502
references.pmid: 4337382
references.citation: Can J Physiol Pharmacol. 2009 Nov;87(11):900-7
references.pmid: 19935897
references.citation: Free Radic Res. 2007 Feb;41(2):234-41
references.pmid: 17364950
references.citation: Phytother Res. 2002 May;16(3):210-6
references.pmid: 12164263
references.citation: J Clin Biochem Nutr. 2007 Nov;41(3):218-23
references.pmid: 18299719
references.citation: Am J Physiol. 1997 Aug;273(2 Pt 2):R725-30
references.pmid: 9277561
references.citation: Diabetes Care. 2010 Dec;33(12):2611-6
references.pmid: 20823343
references.citation: Am J Physiol. 1990 Dec;259(6 Pt 2):R1103-10
references.pmid: 2260721
references.citation: J Clin Psychiatry. 2010 Oct;71(10):1259-72
references.pmid: 21062615
references.citation: Pharmacopsychiatry. 1997 Sep;30 Suppl 2:102-7
references.pmid: 9342769
references.citation: Obesity (Silver Spring). 2007 Apr;15(4):798-808
references.pmid: 17426312
references.citation: Am J Physiol Renal Physiol. 2006 Mar;290(3):F625-31
references.pmid: 16234313
references.citation: Biochem J. 1992 Mar 15;282 ( Pt 3):753-7
references.pmid: 1554357
references.citation: Phytother Res. 2006 Dec;20(12):1023-35
references.pmid: 16909441
references.citation: Pharmacol Res. 2005 Oct;52(4):313-20
references.pmid: 15979893
references.citation: Nutrition. 2007 Jan;23(1):62-8
references.pmid: 17084593
references.citation: J Ethnopharmacol. 2000 Sep;72(1-2):119-28
references.pmid: 10967462
references.citation: Neurosci Lett. 2006 Aug 14;404(1-2):6-8
references.pmid: 16782272
references.citation: Physiol Rev. 2006 Oct;86(4):1237-61
references.pmid: 17015489