title: Dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension.
abstract: OBJECTIVE
  To examine the dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension (IIH).
  
  
  METHODS
  Nonrandomized controlled trial analyzing the difference in cerebral perfusion in 13 IIH patients and 12 healthy controls using contrast-enhanced duplex sonography. In patients, an additional 3D gradient echo magnetic resonance venography (MRV) using a new technique was performed to quantify stenosis of the cerebral sinus. The cerebral perfusion parameters, including cerebral transit time (CTT) and time to peak (TTP), were analyzed.
  
  
  RESULTS
  IIH patients had a higher BMI (29.3 [95% CI 26.4, 32.2] vs. 23.3 [95% CI 20.7, 25.9], p = 0.003) and an increased prevalence of headache, but all other clinical characteristics were comparable. The CTT did not differ significantly. The TTP was significantly longer in IIH patients compared to controls (8.5 [95% CI 7.6, 9.4] vs. 7.3 s [95% CI 6.3, 8.1], p = 0.04). Twelve of 13 (92%) IIH patients showed stenosis of the cerebral sinus.
  
  
  CONCLUSIONS
  Our study is the first to report an altered cerebral venous flow in IIH patients compared to controls using a dynamic ultrasonographic technique. A simplified MRV technique confirms the high prevalence and reliable detection of venous stenosis in IIH patients.
authors.affiliation: Department of Neurology, Technische Universität München, Munich, Germany. ksander1@mac.com
authors.forename: K
authors.initials: K
authors.lastname: Sander
authors.forename: H
authors.initials: H
authors.lastname: Poppert
authors.forename: T
authors.initials: T
authors.lastname: Etgen
authors.forename: B
authors.initials: B
authors.lastname: Hemmer
authors.forename: D
authors.initials: D
authors.lastname: Sander
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003392:Cranial Sinuses / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods; D011559:Pseudotumor Cerebri / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D018616:Ultrasonography, Doppler, Duplex