title: [Correlation studies between urinary retinol binding  protein and renal tubular damage].
abstract: OBJECTIVE
  To study correlation between urinary retinol binding protein (RBP) content and renal tubular damage.
  
  
  METHODS
  A total of 1 353 healthy people and 186 patients with renal tubular damage diagnosed by renal biopsy were enrolled. The indicators such as endogenous creatinine clearance rate (Ccr), creatinine(Cr), urinary retinol binding protein(RBP), urinary β(2)-microglobulin(β(2)-MG), urinary N-acety1-beta-D-glucosaminidase (NAG), urine specific gravity(SG), urine osmolality of the 2 groups were examined and compared. Score of tubulointerstitial impairing and all indicators were analyzed by Spearman rank correlation analysis, and the sensitivity and specificity of indicators were calculated.
  
  
  RESULTS
  Renal tubular damage was positively correlated with urinary RBP, β2-MG, NAG (r=0.863, P<0.001; r=0.777, P<0.001; r=0.374, P=0.002, respectively), while negatively correlated with urine osmolaling, SG (r=-0.519, P<0.001; r=-0.624, P<0.001, respectively). The specificity and sensitivity for renal tubular damage of RBP were 91.03% and 72.06%.
  
  
  CONCLUSIONS
  RBP is an idea marker for renal tubular damage, and is useful to diagnose renal tubular damage and assess the extent of the damage.
authors.affiliation: Huazhong University of Science and Technology,Wuhan, China. xyc0188@yahoo.com.cn
authors.forename: Yuncheng
authors.initials: Y
authors.lastname: Xia
authors.forename: Canhui
authors.initials: C
authors.lastname: Peng
authors.forename: Shen
authors.initials: S
authors.lastname: Qu
authors.forename: Fuyou
authors.initials: F
authors.lastname: Liu
authors.forename: Youming
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine*; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D054840:Retinol-Binding Proteins, Cellular / Q000652:urine*; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D015415:Biomarkers; D054840:Retinol-Binding Proteins, Cellular; D001613:beta 2-Microglobulin; D003404:Creatinine; D000118:Acetylglucosaminidase