title: Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence.
abstract: The efflux pump AcrAB is important in the antibiotic resistance and virulence of several pathogenic bacteria. We report that deletion of the Yersinia pestis AcrAB-TolC homolog leads to increased susceptibility to diverse substrates, including, though unlike in Escherichia coli, the aminoglycosides. Neither is the Y. pestis pump affected by the efflux pump inhibitor phenylalanine-arginine beta-naphthylamide. In mouse plague models, pump deletion does not have a significant effect on tissue colonization.
authors.affiliation: Center of Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Ida M
authors.initials: IM
authors.lastname: Lister
authors.forename: Connor
authors.initials: C
authors.lastname: Raftery
authors.forename: Joan
authors.initials: J
authors.lastname: Mecsas
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Levy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D005260:Female; D017353:Gene Deletion; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010930:Plague / Q000382:microbiology; D014774:Virulence; D015010:Yersinia pestis / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins
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