title: Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter             in clear cell renal cell carcinomas.
abstract: The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor             suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently             altered in colon and gastric cancers and also in leukaemias. In this study we             investigated the promoter region methylation as a possible mechanism of LRRC3B             gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B             gene promoter was methylated in 43% of clear cell renal carcinoma samples. However,             no correlation between DNA methylation and LRRC3B expression was found.
authors.affiliation: Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine. o.g.kondratov@imbg.org.ua
authors.forename: A G
authors.initials: AG
authors.lastname: Kondratov
authors.forename: L A
authors.initials: LA
authors.lastname: Stoliar
authors.forename: S M
authors.initials: SM
authors.lastname: Kvasha
authors.forename: V V
authors.initials: VV
authors.lastname: Gordiyuk
authors.forename: Y M
authors.initials: YM
authors.lastname: Zgonnyk
authors.forename: A V
authors.initials: AV
authors.lastname: Gerashchenko
authors.forename: A F
authors.initials: AF
authors.lastname: Vozianov
authors.forename: A V
authors.initials: AV
authors.lastname: Rynditch
authors.forename: E R
authors.initials: ER
authors.lastname: Zabarovsky
authors.forename: V I
authors.initials: VI
authors.lastname: Kashuba
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000503:physiopathology*; D019175:DNA Methylation; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D009367:Neoplasm Staging; D011401:Promoter Regions, Genetic
chemical_list: C477813:LRRC3B protein, human; D009363:Neoplasm Proteins