title: Cocaine self-administration in Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats.
abstract: Individuals prone to drug self-administration may be vulnerable not only to a single drug reinforcer but to a variety of drug reinforcers. It has been shown that two thirds of alcoholics regularly use drugs other than ethanol (alcohol). Up to 30% of alcohol-dependent patients report concurrent misuse of cocaine. The aim of the present study was to investigate intravenous cocaine self-administration in selectively bred, alcohol-preferring WHP (Warsaw high-preferring) and non-preferring WLP (Warsaw low-preferring) rats. It was hypothesized that WHPs could be more prone to cocaine self-administration in comparison to WLPs. Rats from both lines were allowed to nose-poke for cocaine infusions (0.33 mg/kg/infusion) under the FR-1, FR-2, and FR-3 schedule of reinforcement. Dose-response curves were assessed with increasing doses of cocaine (0.03, 0.1, 0.33, 1.0mg/kg/infusion). The WHP and WLP rats did not differ in cocaine self-administration. Both groups quickly acquired nose-poke responding for cocaine, presented a similar response profile when the schedule of reinforcement was increased from FR-1 to FR-3, and similar sensitivity to cocaine in the dose-response test. The present results may indicate that the selective breeding of alcohol-preferring WHP and alcohol non-preferring WLP rats did not lead to differences in cocaine's rewarding effects as assessed in the self-administration procedure.
authors.affiliation: Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St., PL-02957 Warsaw, Poland.
authors.forename: Albert
authors.initials: A
authors.lastname: Acewicz
authors.forename: Pawel
authors.initials: P
authors.lastname: Mierzejewski
authors.forename: Wanda
authors.initials: W
authors.lastname: Dyr
authors.forename: Agata
authors.initials: A
authors.lastname: Jastrzebska
authors.forename: Izabela
authors.initials: I
authors.lastname: Korkosz
authors.forename: Edyta
authors.initials: E
authors.lastname: Wyszogrodzka
authors.forename: Pawel
authors.initials: P
authors.lastname: Nauman
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kostowski
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Bienkowski
mesh_terms: D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D003042:Cocaine / Q000008:administration & dosage*; D004198:Disease Susceptibility / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007260:Infusion Pumps; D008297:Male; D051381:Rats; D012646:Self Administration; D019966:Substance-Related Disorders / Q000209:etiology
chemical_list: D000438:Alcohols; D003042:Cocaine