title: The development of fear learning and generalization in 8-13 year-olds.
abstract: The current study examined developmental changes in fear learning and generalization in 40 healthy 8-13 year-olds using an aversive conditioning paradigm adapted from Lau et al. [Lau et al. [2008] Journal of the American Academy of Child and Adolescent Psychiatry 47:94-102]. In this task, the conditioned stimuli (CS+/CS-) are two neutral female faces, and the unconditioned stimulus is a fearful, screaming face. The second phase of the study also included a generalization stimulus (GS): a 50% blend of the CS± faces. The eye-blink startle reflex was utilized to measure defensive responding. Patterns of fear learning and generalization were qualified by child age. Older children demonstrated greater fear learning (i.e., larger startle during CS+ than CS-) than younger children. In addition, older children exhibited the typical pattern of generalization observed in adults, whereas younger children did not. Finally, fear learning also related to contingency awareness; only children who correctly identified the CS+ demonstrated fear-potentiated startle to the CS+. Clinical implications and future directions are discussed.
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, New York 11794-2500, USA. cassie.glenn@gmail.com
authors.forename: Catherine R
authors.initials: CR
authors.lastname: Glenn
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Klein
authors.forename: Shmuel
authors.initials: S
authors.lastname: Lissek
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Britton
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Greg
authors.initials: G
authors.lastname: Hajcak
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D002648:Child; D002657:Child Development; D003214:Conditioning, Classical; D005239:Fear / Q000523:psychology*; D005260:Female; D005793:Generalization, Psychological / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D013216:Reflex, Startle
references.citation: Behav Res Ther. 2008 May;46(5):678-87
references.pmid: 18394587
references.citation: Behav Neurosci. 1993 Dec;107(6):970-80
references.pmid: 8136072
references.citation: Dev Psychobiol. 2000 Nov;37(3):153-75
references.pmid: 11044863
references.citation: Psychiatry Res. 2009 Aug 15;168(3):242-9
references.pmid: 19564050
references.citation: Psychophysiology. 2005 Jan;42(1):1-15
references.pmid: 15720576
references.citation: Behav Neurosci. 1986 Feb;100(1):11-22
references.pmid: 3954873
references.citation: J Abnorm Psychol. 2009 May;118(2):311-21
references.pmid: 19413406
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4500-5
references.pmid: 21368210
references.citation: Psychophysiology. 1990 Sep;27(5):513-22
references.pmid: 2274614
references.citation: Cereb Cortex. 1996 Mar-Apr;6(2):215-25
references.pmid: 8670652
references.citation: Biol Psychol. 2008 Dec;79(3):337-42
references.pmid: 18822341
references.citation: Biol Psychiatry. 1998 Nov 15;44(10):990-7
references.pmid: 9821563
references.citation: Behav Res Ther. 2006 Oct;44(10):1491-502
references.pmid: 16360117
references.citation: Acta Psychol (Amst). 2008 Mar;127(3):567-80
references.pmid: 18226795
references.citation: J Clin Child Adolesc Psychol. 2011;40(2):220-32
references.pmid: 21391019
references.citation: J Am Acad Child Adolesc Psychiatry. 2009 Jun;48(6):610-617
references.pmid: 19454917
references.citation: Brain Res. 2006 Jan 12;1068(1):213-20
references.pmid: 16403475
references.citation: Behav Res Ther. 2005 Nov;43(11):1391-424
references.pmid: 15885654
references.citation: Depress Anxiety. 2011 Jan;28(1):5-17
references.pmid: 20734364
references.citation: Dev Psychopathol. 2009 Winter;21(1):47-68
references.pmid: 19144222
references.citation: J Affect Disord. 2000 Dec;61(3):137-59
references.pmid: 11163418
references.citation: Biol Psychiatry. 2010 Feb 15;67(4):297-303
references.pmid: 19846065
references.citation: Biol Psychiatry. 2002 Jun 1;51(11):851-8
references.pmid: 12022957
references.citation: Am J Psychiatry. 2010 Jan;167(1):47-55
references.pmid: 19917595
references.citation: J Neurosci. 2000 Apr 15;20(8):3033-40
references.pmid: 10751455
references.citation: J Am Acad Child Adolesc Psychiatry. 2008 Jan;47(1):94-102
references.pmid: 18174830
references.citation: Genes Brain Behav. 2009 Feb;8(1):80-5
references.pmid: 19220486
references.citation: Psychophysiology. 1991 Sep;28(5):588-95
references.pmid: 1758934
references.citation: Behav Neurosci. 2004 Oct;118(5):916-24
references.pmid: 15506874
references.citation: Behav Neurosci. 1993 Oct;107(5):887-91
references.pmid: 8280399
references.citation: J Exp Child Psychol. 2011 Oct;110(2):159-70
references.pmid: 21440905
references.citation: Behav Res Ther. 2008 Aug;46(8):954-67
references.pmid: 18539262
references.citation: Nat Neurosci. 2001 Apr;4(4):437-41
references.pmid: 11276236
references.citation: Biol Psychol. 2012 Jan;89(1):156-62
references.pmid: 22015709
references.citation: Biol Psychiatry. 2002 Nov 15;52(10):958-75
references.pmid: 12437937
references.citation: Child Adolesc Psychiatr Clin N Am. 2005 Oct;14(4):631-48, vii
references.pmid: 16171696
references.citation: Biol Psychiatry. 1998 Dec 15;44(12):1229-38
references.pmid: 9861466