title: [Carnitine: function, metabolism and value in hepatic failure during chronic alcohol intoxication].
abstract: Alcoholism is one of the most frequent dependences among people, leading to damage of the liver and death of the person. Chronic alcohol consumption decreases fatty acid oxidation by interfering with carnitine metabolism and citric acid cycle activity. Block in activity of the citric acid cycle caused by alcohol and its metabolites is partially compensated by increased ketone body production, which results in ketosis. Chronic administration of alcohol induces liver injury, inflammation, cirrhosis, focal necrosis and steatosis.    L-carnitine (L-3-hydroxy-4-N, N, N-trimethylaminebutyric acid) is an essential factor in fatty acid metabolism, which plays a major role in transport of activated long-chain fatty acids to sites of β-oxidation in mitochondria. Carnitine also stabilizes cell membranes by removing long-chain acyl-CoA and excess of the acyl group from the body. L-carnitine can be a useful and safe drug in the liver pathology induced by chronic ethanol exposure.
authors.affiliation: Zakład Biochemii i Medycyny Doświadczalnej, Instytut Pomnik-Centrum Zdrowia Dziecka w Warszawie. secesja71@poczta.onet.pl
authors.forename: Alina
authors.initials: A
authors.lastname: Kępka
authors.forename: Sławomir Dariusz
authors.initials: SD
authors.lastname: Szajda
authors.forename: Napoleon
authors.initials: N
authors.lastname: Waszkiewicz
authors.forename: Paweł
authors.initials: P
authors.lastname: Płudowski
authors.forename: Sylwia
authors.initials: S
authors.lastname: Chojnowska
authors.forename: Michał
authors.initials: M
authors.lastname: Rudy
authors.forename: Agata
authors.initials: A
authors.lastname: Szulc
authors.forename: Jerzy Robert
authors.initials: JR
authors.lastname: Ladny
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D002331:Carnitine / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008099:Liver / Q000378:metabolism; D017093:Liver Failure / Q000209:etiology / Q000378:metabolism*; D014803:Vitamin B Complex / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D014803:Vitamin B Complex; D002331:Carnitine