title: Nicking enzyme based homogeneous aptasensors for amplification detection of protein.
abstract: A simple and highly sensitive homogeneous aptasensor is developed, which relies on nicking enzyme. The sensitivity of this newly proposed aptasensor is about three orders of magnitude higher than that of traditional homogeneous aptasensors. Furthermore, it is capable of detecting target protein in real samples.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, PR China.
authors.forename: Ai-Xian
authors.initials: AX
authors.lastname: Zheng
authors.forename: Jin-Ru
authors.initials: JR
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Song
authors.forename: Guo-Nan
authors.initials: GN
authors.lastname: Chen
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D001483:Base Sequence; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013917:Thrombin / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D004798:Enzymes; D009841:Oligonucleotides; D013917:Thrombin