title: Perthes' disease: deprivation and decline.
abstract: BACKGROUND
  Perthes' disease is a childhood hip disorder which frequently precipitates premature osteoarthritis necessitating joint replacement in young adults. The highest incidence reported worldwide is in Merseyside, UK, where a unique disease register is maintained.
  
  
  OBJECTIVE
  To describe the temporal trends in disease incidence in a geographically defined area of Merseyside, and to examine the relationship to area deprivation.
  
  
  METHODS
  Descriptive observational study utilising a regional disease register in Merseyside, UK, 1976-2009.
  
  
  METHODS
  1082 children with Perthes' disease (682 from a geographically defined area).
  
  
  RESULTS
  Disease incidence by region, year and deprivation quintile (measured by the Index of Multiple Deprivation 2007, and the Child Well-Being Index 2009).
  
  
  RESULTS
  There was a dramatic decline in incidence over the study period in Liverpool, with rates falling from 14.2 to 7.7 cases/10,000 0-14-year-olds (p<0.001). Incidence rates halved in nearby Knowsley (p=0.01) but remained largely static in the more affluent region of Sefton, where the annual incidence remained at around 7.2 cases/10,000 0-14-year-olds (p=0.73). The association with area deprivation is striking, with the most deprived quintiles having over three times the incidence of the most affluent quintiles (11.5 vs 3.8 cases/10,000 0-14-year-olds; p<0.001). Incidence by electoral ward was strongly correlated to ward deprivation score (p<0.001).
  
  
  CONCLUSIONS
  There was a marked decline in disease incidence over the study period, particularly in more deprived areas. The magnitude of the association with deprivation, and the changing incidence, strongly suggest that environmental factor(s) are a major aetiological determinant in Perthes' disease.
authors.affiliation: Department of Children's Orthopaedic Surgery, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK. danperry@doctors.org.uk
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Perry
authors.forename: Colin E
authors.initials: CE
authors.lastname: Bruce
authors.forename: Daniel
authors.initials: D
authors.lastname: Pope
authors.forename: Peter
authors.initials: P
authors.lastname: Dangerfield
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Platt
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hall
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005260:Female; D005544:Forecasting; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007873:Legg-Calve-Perthes Disease / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D011204:Poverty Areas; D012307:Risk Factors; D012959:Socioeconomic Factors