title: Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo.
abstract: Cisplatin (DDP) is widely used in lung cancer chemotherapy. However, cisplatin resistance represents a major obstacle in effective clinical treatment. This study aims to investigate whether Newcastle disease virus (NDV) exhibits an oncolytic effect on cisplatin-resistant A549 lung cancer cells. We found that NDV induced A549/DDP cell apoptosis via the caspase pathway, particularly involving caspase-9, while the mitogen-activated protein kinase (MAPK) and Akt pathways also contributed to apoptotic induction. Furthermore, NDV displayed oncolytic effects in a mouse A549/DDP lung cancer model. Collectively, our data indicate that NDV could overcome the cisplatin resistance in lung cancer cells in vitro and in vivo.
authors.affiliation: State Key Laboratory of Veterinary Biotechnology, Harbin 150001, China.
authors.forename: Songshu
authors.initials: S
authors.lastname: Meng
authors.forename: Zhizhi
authors.initials: Z
authors.lastname: Zhou
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Xiangang
authors.initials: X
authors.lastname: Kong
authors.forename: Huairan
authors.initials: H
authors.lastname: Liu
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Liu
authors.forename: Maozhi
authors.initials: M
authors.lastname: Hu
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Zhang
authors.forename: Chan
authors.initials: C
authors.lastname: Ding
authors.forename: Yantao
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000628:therapy* / Q000821:virology; D000077192:Adenocarcinoma of Lung; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D053453:Caspase 9 / Q000378:metabolism; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009522:Newcastle disease virus / Q000254:growth & development / Q000472:pathogenicity*; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000254:growth & development / Q000472:pathogenicity*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014779:Virus Replication; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D051057:Proto-Oncogene Proteins c-akt; D020928:Mitogen-Activated Protein Kinases; C506433:CASP9 protein, human; D053453:Caspase 9; D002945:Cisplatin