title: Relationship between vitamin D and hyperglycemia in older people from a nationally representative population survey.
abstract: OBJECTIVE
  To investigate the association between vitamin D levels and hyperglycemia in a national community sample of older people.
  
  
  METHODS
  Cross-sectional, nationally representative sample.
  
  
  METHODS
  Community.
  
  
  METHODS
  Two thousand thirty-eight noninstitutitionalized adults aged 65 and older taking part in the Health Survey for England 2005.
  
  
  METHODS
  Serum 25-hydroxy vitamin D (25(OH) D) levels, glycosylated hemoglobin (HbA1c), and covariates: age, sex, social class, season of examination, use of vitamin supplements, and physical health status.
  
  
  RESULTS
  Hyperglycemia was independently associated with low vitamin D levels (odds ratio (OR) = 2.30, 95% confidence interval (CI) = 1.20-4.42 for 25(OH)D <25.0 nmol/L and OR = 2.09, 95% CI = 1.22-3.58 for 25(OH)D 25.0-49.9 nmol/L) but not for 25(OH)D between 50.0 and 74.9 nmol/L (OR = 1.49, 95% CI = 0.85-2.62).
  
  
  CONCLUSIONS
  The higher-than-expected co-occurrence of low vitamin D levels and hyperglycemia (HbA1c ≥ 6.5%) are important public health concerns for older populations living in northern latitudes because both are common, and both have substantial adverse health consequences. Ensuring adequate vitamin D levels may help reverse the increasing trend in the development of diabetes mellitus and related complications in older people.
authors.affiliation: Department of Epidemiology and Public Health, Royal Free and University College London, London, UK. v.hirani@ucl.ac.uk
authors.forename: Vasant
authors.initials: V
authors.lastname: Hirani
mesh_terms: D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004739:England; D005260:Female; D015577:Geriatric Assessment; D006442:Glycated Hemoglobin / Q000378:metabolism; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D017711:Nonlinear Dynamics; D016017:Odds Ratio; D012621:Seasons; D012737:Sex Factors; D012959:Socioeconomic Factors; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D006442:Glycated Hemoglobin; D014807:Vitamin D; C517652:hemoglobin A1c protein, human; C104450:25-hydroxyvitamin D