title: [Effects of incretion hormones on growth pituitary adenoma ectomy and evaluation of long-term therapeutic efficacy].
abstract: OBJECTIVE
  To investigate the effect of incretion hormones on growth pituitary adenoma ectomy patients and evaluate its long-term therapeutic efficacy.
  
  
  METHODS
  A total of 38 growth pituitary adenoma patients were treated by adenoma ectomy between 2002 to 2009 at our hospital. The dynamic concentrations of serum prolactin (PRL), growth hormone (GH), cortisone, adrenocorticotrophic hormone (ACTH) and thyroid function (T3, T4 & thyroid-stimulating hormone) were monitored before and after microsurgery. All cases had been followed up for over one year to evaluate the long-term therapeutic efficacy.
  
  
  RESULTS
  The level of GH decreased markedly within one week after ectomy [(2.49 ± 0.22) µg/L vs (9.24 ± 0.56) µg/L, P < 0.05] and remained stable afterwards. Among 22 cases of GH-secreting pituitary adenoma with total removal, the post-operative level of GH dropped below 2.5 µg/L in 11 cases but the other 11 cases did not. And 3 cases were recurrent within 3 years post-operation.
  
  
  CONCLUSIONS
  The GH level at Week 1 post-operation is one of the major indicators for evaluating the efficacy of surgery. And the level of GH dropping below 2.5 µg/L at Week 1 post-operation may be used as a standard for clinical cure.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. kongbo1984.happy@163.com
authors.forename: Bo
authors.initials: B
authors.lastname: Kong
authors.forename: Wen-de
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000145:classification / Q000378:metabolism* / Q000601:surgery; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone