title: Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives.
abstract: BACKGROUND
  4-(3-Trifluoromethylphenyl)pyridazine represents a new series of compounds with bleaching and herbicidal activities.
  
  
  RESULTS
  A total of 43 novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives were synthesised, and their bleaching and herbicidal activities were evaluated through Spirodela polyrrhiza and greenhouse tests. Some compounds exhibited excellent herbicidal activities, even at a dose of 7.5 g ha(-1).
  
  
  CONCLUSIONS
  The results showed that a substituted phenoxy group at the 3-position of the pyridazine ring and the electron-withdrawing group at the para-position on the benzene ring were essential for high herbicidal activity.
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, National Engineering Research Center of Pesticide (Tianjin), Nankai University, Tianjin, China.
authors.forename: Han
authors.initials: H
authors.lastname: Xu
authors.forename: You-Quan
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Xiao-Mao
authors.initials: XM
authors.lastname: Zou
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Fang-Zhong
authors.initials: FZ
authors.lastname: Hu
authors.forename: Hua-Zheng
authors.initials: HZ
authors.lastname: Yang
mesh_terms: D006540:Herbicides / Q000138:chemical synthesis*; D019684:Magnoliopsida; D015394:Molecular Structure; D011724:Pyridazines / Q000737:chemistry*
chemical_list: D006540:Herbicides; D011724:Pyridazines