title: Distribution of MICA haplotypes in a Chinese Han population.
abstract: The MICA gene encodes nonclassical major histocompatibility complex class I molecules, centromeric to HLA-B and telomeric to HLA-DRB1. The MICA genes are polymorphic. The immune response against MICA may correlate with a decrease in graft survival after transplantation. However, data on the frequency of MICA polymorphisms in different populations are limited. In this study, we determined MICA allelic frequencies in a Han population living in Guangdong Province in south China. A total of 15 MICA alleles were identified using sequence-based typing. The most frequent allele was MICA*010 (22.22%), followed by MICA*002:01(18.56%), MICA*008:01(16.32%), and MICA*019(14.93%). The MICA null gene (MICA*Del) exhibited a frequency of 1.743% in this population. MICA and HLA, MICA-HLA-B, and MICA-HLA-A/HLA-B/HLA-DRB1 haplotype frequencies were estimated. The most common 2-, 3- and 4-locus haplotypes were HLA-B*40:01-MICA*008:01 (13.70%), HLA-A*11:01-B*40:01-MICA*008:01(8.25%), and HLA-A*33:03-B*58:01-DRB1*03:01-MICA*002:01(5.22%). A new MICA allele, MICA*061, was identified and appears to be evolutionarily related to MICA*012:01. This study provides high-resolution information on the distribution of haplotypes with MICA, HLA-A, HLA-B, and HLA-DRB1 in China. This information should help determine the mechanisms underlying diseases and allotransplant rejection associated with MICA polymorphisms in the southern Chinese Han population.
authors.affiliation: Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, 510095 Guangdong, People's Republic of China.
authors.forename: Xiuzhang
authors.initials: X
authors.lastname: Xu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Xia
authors.forename: Linwei
authors.initials: L
authors.lastname: Tian
authors.forename: Yangkai
authors.initials: Y
authors.lastname: Chen
authors.forename: Haoqiang
authors.initials: H
authors.lastname: Ding
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shao
authors.forename: Jing
authors.initials: J
authors.lastname: Deng
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Huang
authors.forename: Sentot
authors.initials: S
authors.lastname: Santoso
authors.forename: Yongshui
authors.initials: Y
authors.lastname: Fu
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006085:Graft Survival / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A