title: Association of epidermal growth factor receptor mutations with metastatic presentations in non-small cell lung cancer.
abstract: We performed this retrospective study to assess the association of epidermal growth factor receptor (EGFR) with metastatic presentations in advanced non-small cell lung cancer (NSCLC). The data from 125 patients with stage III or IV NSCLC were analyzed. We detected EGFR mutations in 36 NSCLC patients. EGFR mutations were predominant in never-smokers (P < .001), patients with adenocarcinomas (P < .001), and female patients (P < .001). When the metastatic sites were analyzed, pleural metastases were associated with a high incidence of EGFR mutations (P = .028). Particularly, pleural metastases with minimal effusion (PMME) were associated with EGFR mutational status (P = .001). Patients with N3 lesions were less likely to harbor EGFR mutations (P = .033). On multivariate analysis, N3 lesions (P = .017) and PMME (P < .001) remained significant factors for EGFR mutations. EGFR mutations may be associated with different presentations of pleural and N3 nodal metastases.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, 215-4, Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea.
authors.forename: Im Il
authors.initials: II
authors.lastname: Na
authors.forename: Jong Heon
authors.initials: JH
authors.lastname: Park
authors.forename: Du Hwan
authors.initials: du H
authors.lastname: Choe
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Jae Soo
authors.initials: JS
authors.lastname: Koh
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