title: Advances in pediatric nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common cause of pediatric liver disease in the developed world. Children have a form of NAFLD that is pathologically distinct from adults. Although NAFLD remains a pathologic diagnosis, biomarkers and imaging studies hold promise as noninvasive means of both establishing the diagnosis and following the disease course. Significant advancements have recently been made in genetics, pathophysiology, and the treatment of NAFLD. The purpose of this article is to provide a clinically relevant review of pediatric NAFLD with an emphasis on recent developments in the field.
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University, 3959 Broadway, CHN 702, New York, NY 10032, USA. jl3553@columbia.edu
authors.forename: Ali A
authors.initials: AA
authors.lastname: Mencin
authors.forename: Joel E
authors.initials: JE
authors.lastname: Lavine
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D002648:Child; D015897:Comorbidity; D003952:Diagnostic Imaging / Q000379:methods; D005234:Fatty Liver / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D015431:Weight Loss
chemical_list: D015415:Biomarkers