title: Pancreatic metastasis in a case of small cell lung carcinoma: Diagnostic role of fine-needle aspiration cytology and immunocytochemistry.
abstract: Small cell lung carcinoma represents a group of highly malignant tumors giving rise to early and widespread metastasis at the time of diagnosis. However, the pancreas is a relatively infrequent site of metastasis by this neoplasm, and there are only occasional reports on its fine needle aspiration (FNA) cytology diagnosis. A 66-year-old man presented with extensive mediastinal lymphadenopathy and a mass in the pancreatic tail. Ultrasound-guided FNA smears from the pancreatic mass contained small, round tumor cells with extensive nuclear molding. The cytodiagnosis was metastatic small cell carcinoma. Immunocytochemical staining showed that a variable number of neoplastic cell were positive for cytokeratin, chromogranin A, neurone-specific enolase and synaptophysin but negative for leukocyte common antigen. The trans-bronchial needle aspiration was non-diagnostic, but biopsy was suspicious of a small cell carcinoma. This case represents a rare metastatic lesion in the pancreas from small cell lung carcinoma, diagnosed by FNA cytology.
authors.affiliation: Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Das
authors.forename: Abdulaziz T
authors.initials: AT
authors.lastname: Muqim
authors.forename: Bahiya I
authors.initials: BI
authors.lastname: Haji
authors.forename: Khalida
authors.initials: K
authors.lastname: Al-Bishi
authors.forename: Rana
authors.initials: R
authors.lastname: Abdulghani
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