title: Non-coding RNAs in human disease.
abstract: The relevance of the non-coding genome to human disease has mainly been studied in the context of the widespread disruption of microRNA (miRNA) expression and function that is seen in human cancer. However, we are only beginning to understand the nature and extent of the involvement of non-coding RNAs (ncRNAs) in disease. Other ncRNAs, such as PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), transcribed ultraconserved regions (T-UCRs) and large intergenic non-coding RNAs (lincRNAs) are emerging as key elements of cellular homeostasis. Along with microRNAs, dysregulation of these ncRNAs is being found to have relevance not only to tumorigenesis, but also to neurological, cardiovascular, developmental and other diseases. There is great interest in therapeutic strategies to counteract these perturbations of ncRNAs.
authors.affiliation: Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain. mesteller@idibell.cat
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics / Q000628:therapy; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D009422:Nervous System Diseases / Q000235:genetics / Q000628:therapy; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism*
chemical_list: D022661:RNA, Untranslated
references.citation: Nat Rev Genet. 2010 Aug;11(8):559-71
references.pmid: 20628352
references.citation: Nucleic Acids Res. 2011 Aug;39(15):6596-607
references.pmid: 21546553
references.citation: Science. 2007 May 4;316(5825):744-7
references.pmid: 17446352
references.citation: J Med Genet. 2002 Dec;39(12):872-5
references.pmid: 12471198
references.citation: Biochem Soc Trans. 2008 Dec;36(Pt 6):1197-200
references.pmid: 19021524
references.citation: Adv Exp Med Biol. 2010;685:215-9
references.pmid: 20687509
references.citation: Hum Mol Genet. 2006 Jan 15;15(2):201-11
references.pmid: 16377660
references.citation: Nature. 2008 Dec 18;456(7224):980-4
references.pmid: 19043405
references.citation: Dev Cell. 2007 Apr;12(4):503-14
references.pmid: 17395546
references.citation: Nature. 2008 Jan 10;451(7175):202-6
references.pmid: 18185590
references.citation: Cold Spring Harb Symp Quant Biol. 2010;75:325-31
references.pmid: 21502407
references.citation: Hum Reprod. 2010 Dec;25(12):2955-61
references.pmid: 20940137
references.citation: BMC Med Genomics. 2010 Nov 23;3:54
references.pmid: 21092253
references.citation: Nat Med. 2008 Jul;14(7):723-30
references.pmid: 18587408
references.citation: Cell. 2006 Mar 24;124(6):1169-81
references.pmid: 16564011
references.citation: Hum Mol Genet. 2008 Apr 1;17(7):1031-42
references.pmid: 18202102
references.citation: Nature. 2006 May 4;441(7089):87-90
references.pmid: 16625209
references.citation: Int J Clin Exp Pathol. 2010 Mar 20;3(4):328-37
references.pmid: 20490325
references.citation: Science. 2009 Dec 11;326(5959):1549-54
references.pmid: 20007902
references.citation: J Neurosci. 2008 Jan 30;28(5):1213-23
references.pmid: 18234899
references.citation: Cell. 2010 Aug 6;142(3):409-19
references.pmid: 20673990
references.citation: Nat Rev Cancer. 2009 Apr;9(4):293-302
references.pmid: 19262572
references.citation: Nat Neurosci. 2008 Oct;11(10):1137-9
references.pmid: 18758459
references.citation: Nature. 2007 Jun 14;447(7146):799-816
references.pmid: 17571346
references.citation: Cell. 2007 Apr 20;129(2):303-17
references.pmid: 17397913
references.citation: Science. 2010 Dec 24;330(6012):1824-7
references.pmid: 21205669
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9136-41
references.pmid: 16754881
references.citation: J Exp Med. 2007 Jul 9;204(7):1553-8
references.pmid: 17606634
references.citation: Oncogene. 2012 Apr 19;31(16):2062-74
references.pmid: 21874049
references.citation: FEBS Lett. 2010 Sep 10;584(17):3812-8
references.pmid: 20655916
references.citation: Clin Chim Acta. 2011 Aug 17;412(17-18):1621-5
references.pmid: 21616063
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60
references.pmid: 17108080
references.citation: Science. 2007 Jun 8;316(5830):1484-8
references.pmid: 17510325
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004
references.pmid: 14973191
references.citation: Nat Genet. 2009 May;41(5):614-8
references.pmid: 19363478
references.citation: J Cell Sci. 2008 Apr 1;121(Pt 7):939-46
references.pmid: 18354083
references.citation: Oncogene. 2010 Dec 2;29(48):6390-401
references.pmid: 20802525
references.citation: PLoS Genet. 2010 Dec 02;6(12):e1001233
references.pmid: 21151960
references.citation: Nat Rev Genet. 2009 Mar;10(3):155-9
references.pmid: 19188922
references.citation: Nucleic Acids Res. 2009 Feb;37(3):e24
references.pmid: 19136465
references.citation: Genome Res. 2007 May;17(5):556-65
references.pmid: 17387145
references.citation: Epigenetics. 2010 Oct 1;5(7):656-63
references.pmid: 20716963
references.citation: Nat Genet. 2007 May;39(5):673-7
references.pmid: 17401365
references.citation: Science. 2009 Aug 21;325(5943):965
references.pmid: 19556464
references.citation: Circ Res. 2007 Jun 8;100(11):1579-88
references.pmid: 17478730
references.citation: Cancer Cell. 2007 Sep;12(3):215-29
references.pmid: 17785203
references.citation: Nat Genet. 2009 May;41(5):572-8
references.pmid: 19377478
references.citation: Nature. 2005 Dec 1;438(7068):685-9
references.pmid: 16258535
references.citation: Nat Genet. 2011 Mar;43(3):242-5
references.pmid: 21278745
references.citation: Nat Genet. 2008 Jun;40(6):719-21
references.pmid: 18500341
references.citation: Nat Med. 2007 Apr;13(4):486-91
references.pmid: 17401374
references.citation: Nat Biotechnol. 2008 Aug;26(8):933-40
references.pmid: 18641635
references.citation: Cell. 2006 Apr 21;125(2):301-13
references.pmid: 16630818
references.citation: Nat Genet. 2007 May;39(5):582-3
references.pmid: 17460676
references.citation: Angew Chem Int Ed Engl. 2010 Jun 21;49(27):4674-7
references.pmid: 20533473
references.citation: Science. 2004 May 28;304(5675):1321-5
references.pmid: 15131266
references.citation: Cell. 1996 Jun 28;85(7):1077-88
references.pmid: 8674114
references.citation: Cell Cycle. 2005 Sep;4(9):1179-84
references.pmid: 16096373
references.citation: Methods. 2008 Jan;44(1):55-60
references.pmid: 18158133
references.citation: Nat Rev Cancer. 2006 Apr;6(4):259-69
references.pmid: 16557279
references.citation: Cell. 1997 May 16;89(4):565-73
references.pmid: 9160748
references.citation: Mol Cell. 2003 Feb;11(2):425-35
references.pmid: 12620230
references.citation: Ann Neurol. 2009 Dec;66(6):843-57
references.pmid: 20035504
references.citation: Science. 2005 Sep 2;309(5740):1559-63
references.pmid: 16141072
references.citation: Carcinogenesis. 2010 Feb;31(2):208-15
references.pmid: 19926640
references.citation: Hum Mol Genet. 2010 Oct 15;19(20):3959-69
references.pmid: 20660113
references.citation: Mamm Genome. 2008 Aug;19(7-8):526-40
references.pmid: 18636290
references.citation: Cell. 2007 Jun 29;129(7):1311-23
references.pmid: 17604720
references.citation: Nature. 2010 Apr 15;464(7291):1071-6
references.pmid: 20393566
references.citation: Cell Cycle. 2008 Aug 15;7(16):2570-83
references.pmid: 18719369
references.citation: Blood. 2001 Jan 15;97(2):426-34
references.pmid: 11154219
references.citation: Cancer Cell. 2010 Oct 19;18(4):303-15
references.pmid: 20951941
references.citation: Cell. 2007 Mar 23;128(6):1089-103
references.pmid: 17346786
references.citation: Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1118-26
references.pmid: 20378849
references.citation: Nat Rev Genet. 2010 Sep;11(9):597-610
references.pmid: 20661255
references.citation: Nat Med. 2011 Mar;17(3):330-9
references.pmid: 21386836
references.citation: Am J Hum Genet. 2007 Aug;81(2):405-13
references.pmid: 17668390
references.citation: Epigenetics. 2010 Jul 1;5(5):427-43
references.pmid: 20448464
references.citation: Brain Res. 2008 Oct 3;1233:176-84
references.pmid: 18708037
references.citation: Nature. 2010 Jul 29;466(7306):637-41
references.pmid: 20671708
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9
references.pmid: 21368194
references.citation: Nat Rev Genet. 2004 Jul;5(7):522-31
references.pmid: 15211354
references.citation: Immunotherapy. 2011 Jul;3(7):829-31
references.pmid: 21751952
references.citation: J Biol Chem. 2010 Jan 8;285(2):1529-43
references.pmid: 19897480
references.citation: Nat Cell Biol. 2010 Mar;12(3):247-56
references.pmid: 20173740
references.citation: Mutat Res. 2011 Mar 15;708(1-2):59-68
references.pmid: 21310163
references.citation: J Biol Chem. 2009 Jan 23;284(4):1971-81
references.pmid: 18986979
references.citation: Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20
references.pmid: 18434550
references.citation: Science. 2007 Aug 31;317(5842):1220-4
references.pmid: 17761882
references.citation: Neuron. 2010 Feb 11;65(3):373-84
references.pmid: 20159450
references.citation: Horm Res. 2009 Apr;71 Suppl 2:30-5
references.pmid: 19407494
references.citation: Biochimie. 2011 Nov;93(11):1987-92
references.pmid: 21664409
references.citation: J Genet Genomics. 2009 Aug;36(8):447-54
references.pmid: 19683667
references.citation: Int J Cancer. 2006 Apr 15;118(8):1922-9
references.pmid: 16287078
references.citation: Nat Methods. 2009 Dec;6(12):873-4
references.pmid: 19935840
references.citation: Nat Genet. 2009 Mar;41(3):365-70
references.pmid: 19219043
references.citation: Cancer Res. 2011 Jan 1;71(1):3-7
references.pmid: 21199792
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references.pmid: 12434020
references.citation: PLoS One. 2007 Mar 14;2(3):e293
references.pmid: 17356702
references.citation: Oncogene. 2007 Feb 15;26(7):1098-100
references.pmid: 16953229
references.citation: Science. 2008 Dec 19;322(5909):1851-4
references.pmid: 19056938
references.citation: PLoS Genet. 2011 Mar;7(3):e1001347
references.pmid: 21455290
references.citation: Science. 2010 Aug 6;329(5992):689-93
references.pmid: 20616235
references.citation: Science. 2006 Jan 13;311(5758):230-2
references.pmid: 16357227
references.citation: Science. 2003 Apr 4;300(5616):131-5
references.pmid: 12649488
references.citation: Cell. 2009 Jun 12;137(6):1005-17
references.pmid: 19524505
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13318-23
references.pmid: 20624952
references.citation: BMB Rep. 2010 Sep;43(9):635-41
references.pmid: 20846497
references.citation: Science. 2007 Mar 16;315(5818):1587-90
references.pmid: 17322028
references.citation: Genes Dev. 2010 May;24(9):887-92
references.pmid: 20439430
references.citation: Nature. 2009 Aug 6;460(7256):705-10
references.pmid: 19578358
references.citation: J Immunol. 2010 Aug 15;185(4):2009-12
references.pmid: 20631304
references.citation: Development. 2004 Feb;131(4):839-49
references.pmid: 14736746
references.citation: Nat Rev Genet. 2009 Oct;10(10):704-14
references.pmid: 19763153
references.citation: Nature. 2009 Mar 12;458(7235):223-7
references.pmid: 19182780
references.citation: Brain Res. 2011 Feb 10;1373:183-8
references.pmid: 21138738
references.citation: Science. 2011 May 13;332(6031):848-52
references.pmid: 21566194
references.citation: Cancer Cell. 2006 Jun;9(6):435-43
references.pmid: 16766263
references.citation: Biochem Biophys Res Commun. 2002 Nov 29;299(2):196-200
references.pmid: 12437969
references.citation: Science. 2008 Dec 19;322(5909):1849-51
references.pmid: 19056940
references.citation: Am J Hum Genet. 2008 Feb;82(2):283-9
references.pmid: 18252210
references.citation: Am J Med Genet A. 2008 Aug 15;146A(16):2041-52
references.pmid: 18627066
references.citation: Cancer Res. 2007 Feb 15;67(4):1424-9
references.pmid: 17308079
references.citation: PLoS One. 2010 Aug 11;5(8):e12132
references.pmid: 20711463
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13052-7
references.pmid: 19628698
references.citation: Nature. 2010 Apr 22;464(7292):1196-200
references.pmid: 20364122
references.citation: Nat Genet. 2006 Jul;38(7):813-8
references.pmid: 16751773
references.citation: Nature. 2008 Apr 17;452(7189):896-9
references.pmid: 18368051
references.citation: Mol Cancer. 2010 Jul 27;9:198
references.pmid: 20663213
references.citation: Nat Rev Genet. 2011 May;12(5):316-28
references.pmid: 21468099
references.citation: Oncogene. 2009 Jan 15;28(2):195-208
references.pmid: 18836484
references.citation: BMC Cancer. 2009 Dec 15;9:441
references.pmid: 20003513
references.citation: Nature. 2010 Sep 2;467(7311):86-90
references.pmid: 20693987
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):786-91
references.pmid: 21187392
references.citation: Science. 2004 Jan 30;303(5658):669-72
references.pmid: 14752161
references.citation: Annu Rev Neurosci. 2006;29:77-103
references.pmid: 16776580
references.citation: RNA Biol. 2010 Sep-Oct;7(5):606-14
references.pmid: 20864815
references.citation: Genes Dev. 2006 Oct 15;20(20):2787-92
references.pmid: 17043308
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13450-5
references.pmid: 20624982
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13111-6
references.pmid: 20616011
references.citation: Nature. 2011 Aug 28;477(7364):295-300
references.pmid: 21874018
references.citation: Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18161-6
references.pmid: 20921386
references.citation: J Neuroimmunol. 2010 Sep 14;226(1-2):165-71
references.pmid: 20637509
references.citation: Nat Med. 2010 Jan;16(1):49-58
references.pmid: 19898489
references.citation: Nat Rev Genet. 2011 Jan;12(1):19-31
references.pmid: 21116305
references.citation: Biochimie. 2002 Aug;84(8):775-90
references.pmid: 12457565
references.citation: Drug Discov Today. 2009 May;14(9-10):446-52
references.pmid: 19429503