title: [Effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation].
abstract: OBJECTIVE
  To assess in a growth retardation (GR) model the impact of different propranolol (P) doses on anthropomorphometric and biomechanical variables of the appendicular skeleton.
  
  
  METHODS
  Twenty-one day-old male Wistar rats were divided into the following groups: control (C), C+P3.5 (CP3.5); C+P7 (CP7); C+P10.5 (CP10.5); C+P14 (CP14); ED, ED+P3.5 (EDP3.5); ED+P7 (EDP7); ED+P10.5 (EDP10.5), and ED+P14 (EDP14). Control animals with/without P were fed a rodent diet ad libitum. GR rats with/without P were given 80% of the same diet per 100g body weight for 4 weeks (T4). Propranolol 3.5, 7, 10.5, and 14 mg/kg/day was intraperitoneally injected 5 days/week for 4 weeks to the CP3.5 and EDP3.5; CP7 and EDP7; CP10.5 and EDP10.5, and CP14 and EDP14 groups respectively.
  
  
  RESULTS
  At T4, energy restriction had negative effects upon overall growth, femur, and its mechanical competence. Propranolol improved bone rigidity in GR animals at doses of 7 and 10.5mg/kg/day, with a maximum response at 7 mg/kg/day.
  
  
  CONCLUSIONS
  Propranolol 7 mg/kg/day would be the most effective dose for modeling incorporation of bone, as shown by the increased skeletal structural and mechanic efficiency in this animal model of growth retardation. Such effect may result from maintenance of mechanosensor viability, changes in its sensitivity, the biomechanical reference point and/or effector response in GR rats.
authors.affiliation: Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, Argentina.
authors.forename: Christian
authors.initials: C
authors.lastname: Esteban Lezón
authors.forename: Patricia Mabel
authors.initials: PM
authors.lastname: Pintos
authors.forename: María Itatí
authors.initials: MI
authors.lastname: Itatí Olivera
authors.forename: Clarisa
authors.initials: C
authors.lastname: Bozzini
authors.forename: Patricia Mónica
authors.initials: PM
authors.lastname: Boyer
mesh_terms: D000818:Animals; D001699:Biometry; D015519:Bone Density / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004548:Elasticity; D005269:Femur / Q000187:drug effects / Q000473:pathology; D005508:Food Deprivation; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology; D010011:Osteocytes / Q000502:physiology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011502:Protein-Energy Malnutrition / Q000150:complications; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D016474:Weight-Bearing
chemical_list: D011433:Propranolol