title: Ten-year survival after liver resection for colorectal metastases: systematic review and meta-analysis.
abstract: Background. Liver resection in metastatic colorectal cancer is proved to result in five-year survival of 25-40%. Several factors have been investigated to look for prognostic factors stratifications such as resection margins, node involvement in the primary disease, and interval between the primary disease and liver metastases. Methods. We searched MEDLINE and EMBASE for studies that reported ten-year survival. Metaanalysis was performed to analyse the effect of recognised prognostic factors on cure rate for colorectal metastases. The meta-analysis was performed according to Ottawa-Newcastle method of analysis for nonrandomised trials and according to the guidelines of the PRISMA. Results. Eleven studies were included in the analysis, which showed a ten-year survival rate of 12-36%. Factors that have favourable impact are clear resection margin, low level of CEA, single metastatic deposit, and node negative disease. The only factor that excluded patients from cure is the positive status of the resection margin. Conclusion. Predicted ten-year survival after liver resection for colorectal metastases varies from 12 to 36%. Only positive resection margins resulted in no 10-year survivors. No patient can be excluded from consideration for liver resection so long the result is negative margins.
authors.affiliation: Westmead Hospital, Wentworthville, NSW 2145, Australia.
authors.forename: Saleh
authors.initials: S
authors.lastname: Abbas
authors.forename: Vincent
authors.initials: V
authors.lastname: Lam
authors.forename: Michael
authors.initials: M
authors.lastname: Hollands
references.citation: J Clin Oncol. 2000 Aug;18(16):2938-47
references.pmid: 10944126
references.citation: J Surg Oncol. 2009 Dec 1;100(7):538-45
references.pmid: 19722234
references.citation: World J Surg. 1995 Jan-Feb;19(1):59-71
references.pmid: 7740812
references.citation: Radiology. 2001 Jan;218(1):55-60
references.pmid: 11152779
references.citation: Ann Surg. 2002 Jun;235(6):759-66
references.pmid: 12035031
references.citation: Ann Surg. 2000 Apr;231(4):487-99
references.pmid: 10749608
references.citation: Ann Surg. 2004 Jun;239(6):818-25; discussion 825-7
references.pmid: 15166961
references.citation: Ann Surg. 1984 May;199(5):502-8
references.pmid: 6721600
references.citation: N Engl J Med. 2000 Sep 28;343(13):905-14
references.pmid: 11006366
references.citation: Ann Surg Oncol. 2006 May;13(5):668-76
references.pmid: 16523369
references.citation: Am J Clin Oncol. 2005 Dec;28(6):547-54
references.pmid: 16317262
references.citation: Eur J Surg Oncol. 2006 Jun;32(5):557-63
references.pmid: 16580811
references.citation: Ann Surg Oncol. 2002 Jun;9(5):430-8
references.pmid: 12052752
references.citation: Surgery. 2008 Mar;143(3):384-93
references.pmid: 18291260
references.citation: J Am Coll Surg. 2006 Mar;202(3):468-75
references.pmid: 16500252
references.citation: Arch Surg. 2004 Nov;139(11):1168-72
references.pmid: 15545561
references.citation: Langenbecks Arch Surg. 2007 Sep;392(5):535-8
references.pmid: 17294210
references.citation: Ann Surg Oncol. 2004 Mar;11(3):238-9
references.pmid: 14993015
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000097
references.pmid: 19621072
references.citation: J Clin Oncol. 2007 Oct 10;25(29):4575-80
references.pmid: 17925551
references.citation: N Engl J Med. 2004 Jun 3;350(23):2335-42
references.pmid: 15175435
references.citation: World J Surg. 1987 Aug;11(4):511-20
references.pmid: 3630196
references.citation: Ann Surg. 2000 Dec;232(6):777-85
references.pmid: 11088072
references.citation: Arch Surg. 2007 Mar;142(3):269-76; discussion 277
references.pmid: 17372052
references.citation: Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21
references.pmid: 10493478
references.citation: Arch Surg. 1997 May;132(5):505-10; discussion 511
references.pmid: 9161393
references.citation: Ann Surg. 2007 Aug;246(2):183-91
references.pmid: 17667495
references.citation: Cancer. 1996 Apr 1;77(7):1254-62
references.pmid: 8608500
references.citation: Arch Surg. 1996 Mar;131(3):322-9
references.pmid: 8611099
references.citation: N Engl J Med. 1999 Dec 30;341(27):2039-48
references.pmid: 10615075
references.citation: J Am Coll Surg. 1997 Dec;185(6):554-9
references.pmid: 9404879
references.citation: Ann Surg. 2004 Sep;240(3):438-47; discussion 447-50
references.pmid: 15319715
references.citation: J Surg Oncol. 2005 Apr 1;90(1):36-42
references.pmid: 15786433
references.citation: Dis Colon Rectum. 2003 Oct;46(10 Suppl):S22-31
references.pmid: 14530655
references.citation: Br J Surg. 2005 Mar;92(3):362-9
references.pmid: 15672427
references.citation: Ann Surg. 2002 Jun;235(6):863-71
references.pmid: 12035044
references.citation: Surgery. 1994 Oct;116(4):703-10; discussion 710-1
references.pmid: 7940169
references.citation: Br J Surg. 2003 Aug;90(8):963-9
references.pmid: 12905549
references.citation: AJR Am J Roentgenol. 1998 May;170(5):1341-7
references.pmid: 9574613