title: Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy.
abstract: BACKGROUND
  Heredity from mother or father may impact differently in complex diseases, such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates.
  
  
  OBJECTIVE
  To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates.
  
  
  METHODS
  Eighteen cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort.
  
  
  RESULTS
  Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015).
  
  
  CONCLUSIONS
  Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.
authors.affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark.
authors.forename: Nilofar V
authors.initials: NV
authors.lastname: Følsgaard
authors.forename: Bo L
authors.initials: BL
authors.lastname: Chawes
authors.forename: Morten A
authors.initials: MA
authors.lastname: Rasmussen
authors.forename: Anne L
authors.initials: AL
authors.lastname: Bischoff
authors.forename: Charlotte G
authors.initials: CG
authors.lastname: Carson
authors.forename: Jakob
authors.initials: J
authors.lastname: Stokholm
authors.forename: Louise
authors.initials: L
authors.lastname: Pedersen
authors.forename: Trevor T
authors.initials: TT
authors.lastname: Hansel
authors.forename: Klaus
authors.initials: K
authors.lastname: Bønnelykke
authors.forename: Susanne
authors.initials: S
authors.lastname: Brix
authors.forename: Hans
authors.initials: H
authors.lastname: Bisgaard
mesh_terms: D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics* / Q000378:metabolism; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D009297:Nasal Mucosa / Q000378:metabolism*; D025341:Principal Component Analysis; D011446:Prospective Studies
chemical_list: D018925:Chemokines; D016207:Cytokines