title: 3D statistical parametric mapping of quiet sleep EEG in the first year of life.
abstract: This paper extends previously developed 3D SPM for Electrophysiological Source Imaging (Bosch et al., 2001) for neonate EEG. It builds on a prior paper by our group that established age dependent means and standard deviations for the scalp EEG Broad Band Spectral Parameters of children in the first year of life. We now present developmental equations for the narrow band log spectral power of EEG sources, obtained from a sample of 93 normal neonates from age 1 to 10 months in quiet sleep. The main finding from these regressions is that EEG power from 0.78 to 7.5 Hz decreases with age and also for 45-50 Hz. By contrast, there is an increase with age in the frequency band of 19-32 Hz localized to parietal, temporal and occipital areas. Deviations from the norm were analyzed for normal neonates and 17 with brain damage. The diagnostic accuracy (measured by the area under the ROC curve) of EEG source SPM is 0.80, 0.69 for average reference scalp EEG SPM, and 0.48 for Laplacian EEG SPM. This superior performance of 3D SPM over scalp qEEG suggests that it might be a promising approach for the evaluation of brain damage in the first year of life.
authors.affiliation: Centro de Neurociencias de Cuba, Avenida 25 y 158, Playa, La Habana, Cuba. bosch@cneuro.edu.cu
authors.forename: Jorge
authors.initials: J
authors.lastname: Bosch-Bayard
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Valdés-Sosa
authors.forename: Thalía
authors.initials: T
authors.lastname: Fernandez
authors.forename: Gloria
authors.initials: G
authors.lastname: Otero
authors.forename: Bernardo
authors.initials: B
authors.lastname: Pliego Rivero
authors.forename: Josefina
authors.initials: J
authors.lastname: Ricardo-Garcell
authors.forename: Berta
authors.initials: B
authors.lastname: González-Frankenberger
authors.forename: Lídice
authors.initials: L
authors.lastname: Galán-García
authors.forename: Antonio
authors.initials: A
authors.lastname: Fernandez-Bouzas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Aubert-Vazquez
authors.forename: Agustin
authors.initials: A
authors.lastname: Lage-Castellanos
authors.forename: René
authors.initials: R
authors.lastname: Rodríguez-Valdés
authors.forename: Thalía
authors.initials: T
authors.lastname: Harmony
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007223:Infant; D008297:Male; D012044:Regression Analysis; D012890:Sleep / Q000502:physiology*