title: Image-guided microwave ablation of hepatic tumours: preliminary experience.
abstract: OBJECTIVE
  Microwave thermal ablation (MWA) opens up a new scenario in the field of image-guided tumour ablation thanks to its potential advantages over validated radiofrequency ablation (RFA). In this pilot study, we assessed the technical success, safety and efficacy of MWA in treating hepatic malignancies.
  
  
  METHODS
  After obtaining informed consent, we enrolled 15 inoperable patients, for a total of 19 lesions (ten metastases, nine hepatocellular carcinoma) with a mean diameter of 47 mm (range 14-78 mm). Mean follow-up was 8 (range 1-14) months.
  
  
  RESULTS
  Technical success reached 100%. Complications (one major and one minor) occurred in two cases. Complete ablation, obtained in 68.4% of cases, showed no significant correlation with either cancer histological type or with lesion diameter. At follow-up, treatment failures occurred in 60% of cases; lesion diameter was the only prognostic factor for maintaining complete ablation.
  
  
  CONCLUSIONS
  Our preliminary results should encourage further trials of this technique. MWA proved to be feasible and safe in treating advanced-stage liver tumours and represented an additional therapeutic attempt to be validated in further and larger efficacy studies.
authors.affiliation: Istituto di Radiologia, Università di Torino, Facoltà San Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, Torino, Italy. andrea.veltri@unito.it
authors.forename: A
authors.initials: A
authors.lastname: Veltri
authors.forename: C
authors.initials: C
authors.lastname: Gazzera
authors.forename: C
authors.initials: C
authors.lastname: Rotondella
authors.forename: F
authors.initials: F
authors.lastname: Camerano
authors.forename: M
authors.initials: M
authors.lastname: Busso
authors.forename: G
authors.initials: G
authors.lastname: Gandini
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008872:Microwaves / Q000627:therapeutic use*; D010865:Pilot Projects; D016896:Treatment Outcome
references.citation: World J Gastroenterol. 2010 Feb 28;16(8):927-33
references.pmid: 20180230
references.citation: Am J Surg. 2008 Apr;195(4):508-20
references.pmid: 18361927
references.citation: Crit Rev Biomed Eng. 2010;38(1):65-78
references.pmid: 21175404
references.citation: J Vasc Interv Radiol. 2010 Aug;21(8 Suppl):S192-203
references.pmid: 20656229
references.citation: Liver Transpl. 2007 Apr;13(4):543-51
references.pmid: 17394152
references.citation: Surg Oncol. 2010 Mar;19(1):e22-32
references.pmid: 19268571
references.citation: Semin Liver Dis. 2010 Feb;30(1):52-60
references.pmid: 20175033
references.citation: J Vasc Interv Radiol. 2003 Sep;14(9 Pt 2):S199-202
references.pmid: 14514818
references.citation: J Vasc Interv Radiol. 2009 Jul;20(7 Suppl):S377-90
references.pmid: 19560026
references.citation: J Clin Oncol. 2010 Jan 20;28(3):493-508
references.pmid: 19841322
references.citation: Radiology. 2011 Feb;258(2):351-69
references.pmid: 21273519
references.citation: Ann Surg. 2005 Aug;242(2):158-71
references.pmid: 16041205
references.citation: World J Surg. 1985 Feb;9(1):136-43
references.pmid: 3984365
references.citation: Radiology. 2002 May;223(2):331-7
references.pmid: 11997534
references.citation: Cardiovasc Intervent Radiol. 2008 Sep-Oct;31(5):948-56
references.pmid: 18506519
references.citation: Ann Surg Oncol. 2010 Jan;17(1):171-8
references.pmid: 19707829
references.citation: Eur J Gastroenterol Hepatol. 2009 Jun;21(6):599-605
references.pmid: 19282763
references.citation: J Gastrointest Surg. 2008 Jan;12(1):183-91
references.pmid: 17874276
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078