title: Histopathology of surgically treated renal tumours in young adults: a developing country perspective.
abstract: BACKGROUND
  There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan.
  
  
  METHODS
  We retrospectively analysed 133 young adults (age: 16 to ≤40 years) who underwent nephrectomy for suspected renal cancer from 1994 till July 2010. The demographical and pathological parameters were determined from original surgical biopsy reports and case files, and analysed.
  
  
  RESULTS
  The mean age of patients was 33.3 ± 6.2 years. Overall, 121 (88.9%) renal tumours were malignant, and 15 (11%) benign. Among malignant tumours, renal cell carcinoma (RCC) was predominant (100/121; 82.6%). The subtypes of RCC included: clear cell RCC, 84 (84%); papillary RCC, 11 (11%), chromophobe RCC, 3 (3%) and sarcomatoid RCC, 2 (2%). Other malignant tumours included: transitional cell carcinoma (9/121; 7.4%), primitive neuroectodermal tumour (5/121; 4.1%), synovial sarcoma (2/121; 1.6%), Non-Hodgkin's lymphoma (2/121; 1.6%), leiomyosarcoma (1/121; 0.8%), malignant fibrous histiocytoma (1/121; 0.8%) and squamous cell carcinoma (1/121; 0.8%). Among benign tumours, there were 11 cases of angiomyolipoma (11/15; 73.3%), three cases of oncocytoma (3/15; 20%) and one case of schwannoma (1/15; 6.6%). Almost two-third (62.7%) patients had stage I/II tumours, 22 (18.1%) stage III and 23 (19%) stage IV disease at the time of surgery.
  
  
  CONCLUSIONS
  A wide variety of renal tumours is documented in young adults with large size of the tumours and late presentation in our population.
authors.affiliation: Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200, Pakistan. drmubaraksiut@yahoo.com
authors.forename: Muhammed
authors.initials: M
authors.lastname: Mubarak
authors.forename: Javed I
authors.initials: JI
authors.lastname: Kazi
authors.forename: Rehan
authors.initials: R
authors.lastname: Mohsin
authors.forename: Altaf
authors.initials: A
authors.lastname: Hashmi
authors.forename: Syed Ali Anwer
authors.initials: SA
authors.lastname: Naqvi
authors.forename: Syed Adeeb
authors.initials: SA
authors.lastname: Ul Hassan Rizvi
mesh_terms: D000293:Adolescent; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D003906:Developing Countries; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D009392:Nephrectomy / Q000379:methods; D010154:Pakistan; D012189:Retrospective Studies; D055815:Young Adult
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