title: Impact of vaccination against Haemophilus influenzae type b with and without a booster dose on meningitis in four South American countries.
abstract: To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either a primary, three-dose immunization schedule without a booster dose or with a booster dose in the second year of life. Surveillance data suggest that high coverage of Hib conjugate vaccine sustained low incidence of Hib meningitis and low prevalence of Hib carriage whether or not a booster dose was used.
authors.affiliation: Pan American Health Organization, Washington, DC, USA. garciasa@paho.org
authors.forename: Salvador
authors.initials: S
authors.lastname: Garcia
authors.forename: Rosanna
authors.initials: R
authors.lastname: Lagos
authors.forename: Alma
authors.initials: A
authors.lastname: Muñoz
authors.forename: Teresa
authors.initials: T
authors.lastname: Picón
authors.forename: Raquel
authors.initials: R
authors.lastname: Rosa
authors.forename: Adriana
authors.initials: A
authors.lastname: Alfonso
authors.forename: Graciela
authors.initials: G
authors.lastname: Abriata
authors.forename: Angela
authors.initials: A
authors.lastname: Gentile
authors.forename: Viviana
authors.initials: V
authors.lastname: Romanin
authors.forename: Mabel
authors.initials: M
authors.lastname: Regueira
authors.forename: Laura
authors.initials: L
authors.lastname: Chiavetta
authors.forename: Clara Inés
authors.initials: CI
authors.lastname: Agudelo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Castañeda
authors.forename: Fernando
authors.initials: F
authors.lastname: De la Hoz
authors.forename: Ana Betty
authors.initials: AB
authors.lastname: Higuera
authors.forename: Patricia
authors.initials: P
authors.lastname: Arce
authors.forename: Adam L
authors.initials: AL
authors.lastname: Cohen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Verani
authors.forename: Patrick
authors.initials: P
authors.lastname: Zuber
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Gabastou
authors.forename: Desiree
authors.initials: D
authors.lastname: Pastor
authors.forename: Brendan
authors.initials: B
authors.lastname: Flannery
authors.forename: Jon
authors.initials: J
authors.lastname: Andrus
mesh_terms: D002675:Child, Preschool; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods; D015994:Incidence; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D013020:South America / Q000453:epidemiology; D014611:Vaccination / Q000379:methods*
chemical_list: D018073:Haemophilus Vaccines