title: Diuretic-associated hyponatremia.
abstract: Soon after their introduction in 1957, thiazide diuretics became a recognized cause of hyponatremia. Thiazides may be the sole cause and they may exacerbate hyponatremia in patients with disorders that cause the syndrome of inappropriate antidiuretic hormone secretion. Although thiazides do not inhibit the ability to concentrate the urine, they impair diluting ability in several ways: inhibition of sodium and chloride transport at cortical diluting sites; stimulation of vasopressin release; reduction of glomerular filtration and enhanced proximal water reabsorption, which reduce delivery to the distal diluting sites; and, possibly, a direct effect on water flow in the collecting duct. Water retention caused by impaired water excretion combined with cation depletion may result in severe hyponatremia. Thiazides should be avoided in frail elderly patients with chronically high water intake or in others who depend on the excretion of maximally dilute urine to maintain fluid balance, such as patients with psychogenic polydipsia or heavy beer drinking. Inadvertent rapid correction of hyponatremia is common in thiazide-induced hyponatremia because the ability to dilute the urine is restored when the diuretic is discontinued and volume deficits are repaired. Hypokalemia, which often is present, increases the susceptibility to osmotic demyelination syndrome and replacement of potassium deficits contributes to the increase in serum sodium concentration.
authors.affiliation: Nephrology Division, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA.
authors.forename: John K
authors.initials: JK
authors.lastname: Hix
authors.forename: Stephen
authors.initials: S
authors.lastname: Silver
authors.forename: Richard H
authors.initials: RH
authors.lastname: Sterns
mesh_terms: D000375:Aging; D004232:Diuretics / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007177:Inappropriate ADH Syndrome / Q000503:physiopathology; D007668:Kidney; D012307:Risk Factors; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects
chemical_list: D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors