title: Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities.
abstract: Helicobacter pylori seroprevalence levels in US adults participating in the continuous National Health and Nutrition Examination Survey (1999-2000) increased with age in all racial/ethnic groups, with significantly higher age-standardized levels in Mexican Americans (64.0%, 95% confidence interval (CI): 58.8, 69.2) and non-Hispanic blacks (52.0%, 95% CI: 48.3, 55.7) compared with non-Hispanic whites (21.2%, 95% CI: 19.1, 23.2). Although seroprevalence levels remained similar to those found in National Health and Nutrition Examination Surveys from 1988 to 1991 among non-Hispanic blacks and Mexican Americans, they were significantly lower in non-Hispanic whites, especially at older ages. The factors driving the decline in H. pylori seroprevalence appear to be acting preferentially on the non-Hispanic white population.
authors.affiliation: Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
authors.forename: Yonatan H
authors.initials: YH
authors.lastname: Grad
authors.forename: Marc
authors.initials: M
authors.lastname: Lipsitch
authors.forename: Allison E
authors.initials: AE
authors.lastname: Aiello
mesh_terms: D000328:Adult; D001741:Black or African American; D017677:Age Distribution; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D003430:Cross-Sectional Studies; D054624:Health Status Disparities; D016481:Helicobacter Infections / Q000097:blood / Q000208:ethnology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006630:Hispanic or Latino; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009749:Nutrition Surveys; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D000907:Antibodies, Bacterial
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