title: [Antimicrobial susceptibility of helicobacter pylori to levofloxacin determined in a miniwell format and disk diffusion tests using egg yolk agar].
abstract: OBJECTIVE
  To determine the Minimum inhibitory concentration (MIC) of Levofloxacin against HELICOBACTER PYLORI (HP).
  
  
  METHODS
  95 HP Peruvian strains were evaluated in Agar dilution and Disk diffusion tests, as well as the Pearson Coefficient (r) and the inoculum's effect.
  
  
  RESULTS
  36.9% (35 of 95) were resistant (MIC>1 μg/ml) to Levofloxacin. MIC₉₀ was 16 ug/ml (CI:90%). MIC of Levofloxacin did not change at different inoculum concentrations. r: -0.733 (p<0.001).
  
  
  CONCLUSIONS
  The proportion of HP Levofloxacin resistant strains in Peru is higher than in developed countries. Periodic testing of antibiotic susceptibility is warranted to select the most accurate therapies.
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Perú.
authors.forename: Humberto
authors.initials: H
authors.lastname: Mochizuki Tamayo
authors.forename: Adrián Pedro
authors.initials: AP
authors.lastname: Noriega Aldave
mesh_terms: D000362:Agar; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods*; D024881:Drug Resistance, Bacterial; D004530:Egg Yolk; D016480:Helicobacter pylori / Q000187:drug effects*; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D010568:Peru
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D000362:Agar; D015242:Ofloxacin