title: [Postprandial lipemia induces endothelial dysfunction and higher insulin resistance in healthy subjects].
abstract: OBJECTIVE
  To assess the effect of postprandial lipemia on endothelial function, insulin resistance, and lipid profile in healthy subjects.
  
  
  METHODS
  A prospective', interventional study in 14 healthy young men aged 18-25 years who were given a high-fat meal. Endothelial function was measured using flow-mediated dilation (FMD) in the brachial artery, flow velocity, mean arterial pressure and serum nitrite/nitrate levels (NO(2)/NO(3)). Glucose, insulin, total cholesterol, and triglyceride levels were also tested. Insulin resistance was determined by calculating the HOMA-IR index (Homeostatic Model Assessment-Insulin Resistance).
  
  
  RESULTS
  Baseline FMD was 5.9 ± 1.1%. Postprandial lipemia reduced endothelial function by approximately 50% in the first (3.3 ± 0.5%, p=0.03) and second (3.3 ± 0.4%, p=0.04) moment respectively. This finding was associated to an increased flow rate in the brachial artery and lower NO(2)/NO(3) levels (p<0.05). Higher cholesterol and triglyceride levels were found 1h and 2h postprandial (p<0.05). HOMA-IR was significantly increased 1h and 2h postprandial (p<0.05).
  
  
  CONCLUSIONS
  Postprandial lipemia causes changes in circulating lipid profile and induces endothelial dysfunction and higher insulin resistance.
authors.affiliation: School of Medicine, University of Valle, Cali, Colombia. robin640@hotmail.com
authors.forename: Robinson
authors.initials: R
authors.lastname: Ramírez-Vélez
mesh_terms: D000293:Adolescent; D000328:Adult; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*; D007333:Insulin Resistance; D008297:Male; D019518:Postprandial Period; D011446:Prospective Studies; D055815:Young Adult