title: Al NMR: a novel NMR data processing program optimized for sparse sampling.
abstract: Sparse sampling in biomolecular multidimensional NMR offers increased acquisition speed and resolution and, if appropriate conditions are met, an increase in sensitivity. Sparse sampling of indirectly detected time domains combined with the direct truly multidimensional Fourier transform has elicited particular attention because of the ability to generate a final spectrum amenable to traditional analysis techniques. A number of sparse sampling schemes have been described including radial sampling, random sampling, concentric sampling and variations thereof. A fundamental feature of these sampling schemes is that the resulting time domain data array is not amenable to traditional Fourier transform based processing and phasing correction techniques. In addition, radial sampling approaches offer a number of advantages and capabilities that are also not accessible using standard NMR processing techniques. These include sensitivity enhancement, sub-matrix processing and determination of minimal sets of sampling angles. Here we describe a new software package (Al NMR) that enables these capabilities in the context of a general NMR data processing environment.
authors.affiliation: Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6059, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Gledhill
authors.forename: A Joshua
authors.initials: AJ
authors.lastname: Wand
mesh_terms: D000465:Algorithms; D001330:Electronic Data Processing; D005583:Fourier Analysis; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D012984:Software
references.citation: J Magn Reson. 2007 May;186(1):142-9
references.pmid: 17293138
references.citation: J Magn Reson. 2007 Feb;184(2):207-21
references.pmid: 17070715
references.citation: J Am Chem Soc. 2005 Sep 14;127(36):12528-36
references.pmid: 16144400
references.citation: J Magn Reson. 2006 Apr;179(2):323-8
references.pmid: 16488634
references.citation: J Biomol NMR. 2006 Nov;36(3):157-68
references.pmid: 17031529
references.citation: Magn Reson Med. 1985 Feb;2(1):86-9
references.pmid: 3831681
references.citation: Prog Nucl Magn Reson Spectrosc. 2010 Nov;57(4):420-34
references.pmid: 20920758
references.citation: J Magn Reson. 2008 Dec;195(2):169-78
references.pmid: 18835206
references.citation: J Am Chem Soc. 2002 Mar 6;124(9):1982-93
references.pmid: 11866612
references.citation: J Am Chem Soc. 2004 May 26;126(20):6429-40
references.pmid: 15149240
references.citation: J Magn Reson. 2010 Feb;202(2):250-8
references.pmid: 20004602
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10876-81
references.pmid: 16043707
references.citation: J Magn Reson. 2007 Oct;188(2):344-56
references.pmid: 17822933
references.citation: J Magn Reson. 2010 Aug;205(2):286-92
references.pmid: 20547466
references.citation: J Biomol NMR. 2003 Oct;27(2):101-13
references.pmid: 12962120
references.citation: Nat Methods. 2006 Aug;3(8):605-7
references.pmid: 16862134
references.citation: Prog Nucl Magn Reson Spectrosc. 2010 Nov;57(4):381-419
references.pmid: 20920757
references.citation: J Magn Reson. 2008 Aug;193(2):317-20
references.pmid: 18547850
references.citation: J Biomol NMR. 2009 Sep;45(1-2):233-9
references.pmid: 19633974
references.citation: J Biomol NMR. 2008 Dec;42(4):225-39
references.pmid: 18853260
references.citation: J Biomol NMR. 2003 Dec;27(4):383-7
references.pmid: 14512735
references.citation: J Am Chem Soc. 2005 Jun 22;127(24):8785-95
references.pmid: 15954785
references.citation: J Magn Reson. 2008 May;192(1):123-30
references.pmid: 18308599
references.citation: J Biomol NMR. 1995 Nov;6(3):277-93
references.pmid: 8520220
references.citation: J Am Chem Soc. 2003 Feb 5;125(5):1385-93
references.pmid: 12553842
references.citation: J Magn Reson. 2007 Aug;187(2):363-70
references.pmid: 17584509
references.citation: J Magn Reson. 2006 Sep;182(1):84-95
references.pmid: 16820311
references.citation: J Am Chem Soc. 2005 Aug 24;127(33):11562-3
references.pmid: 16104707
references.citation: J Biomol NMR. 2006 Sep;36(1):45-54
references.pmid: 16964531