title: Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF).
abstract: Macrophagic myofasciitis (MMF) is characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and cognitive dysfunction. Representative features of MMF-associated cognitive dysfunction (MACD) include (i) dysexecutive syndrome; (i) visual memory; (iii) left ear extinction at dichotic listening test. In present study we retrospectively evaluated the progression of MACD in 30 MMF patients. Most patients fulfilled criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits seemed unusually severe. MACD remained stable over time, although dysexecutive syndrome tended to worsen. Long-term follow-up of a subset of patients with 3 or 4 consecutive neuropsychological evaluations confirmed the stability of MACD with time, despite marked fluctuations.
authors.affiliation: Paris Est-Creteil University & Henri-Mondor University Hospital (APHP): Reference Center for Neuromuscular Diseases Garches-Necker-Mondor-Hendaye, Creteil, F-94010, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Passeri
authors.forename: Chiara
authors.initials: C
authors.lastname: Villa
authors.forename: Maryline
authors.initials: M
authors.lastname: Couette
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
authors.forename: Pierre
authors.initials: P
authors.lastname: Brugieres
authors.forename: Pierre
authors.initials: P
authors.lastname: Cesaro
authors.forename: Romain K
authors.initials: RK
authors.lastname: Gherardi
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bachoud-Levi
authors.forename: François-Jérôme
authors.initials: FJ
authors.lastname: Authier
mesh_terms: D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000150:complications / Q000523:psychology; D003863:Depression / Q000209:etiology; D005208:Fasciitis / Q000139:chemically induced* / Q000150:complications / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced* / Q000150:complications / Q000523:psychology; D009483:Neuropsychological Tests; D012189:Retrospective Studies
chemical_list: D000536:Aluminum Hydroxide