title: New antioxidant and antiglycation active triterpenoid saponins from the root bark of Aralia taibaiensis.
abstract: Four new oleanane type triterpenoid saponins (1-4) and a known saponin (5) were isolated from the root bark of Aralia taibaiensis Z.Z. Wang et H.C. Zheng. The structures of the four new compounds were elucidated as 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucurono-pyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-D-glucopyranosyl ester (1), 3-O-{β-D-gluco-pyranosyl-(1→3)-[α-l-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-D-glucopyranosyl ester (2), 3-O-{β-d-glucopyranosyl-(1→2)-[α-l-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl}-oleanolic acid 28-O-β-D-glucopyranosyl ester (3) and 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucuronopyranosyl}-oleanolic acid 28-O-β-D-glucopyranosyl ester (4), on the basis of extensive spectral analysis and chemical evidence. Compounds 1-5 exhibited moderate effects on antioxidant and antiglycation activities, which correlated with treatment of diabetes mellitus.
authors.affiliation: Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Bi
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Tian
authors.forename: Fang
authors.initials: F
authors.lastname: Dou
authors.forename: Liangjian
authors.initials: L
authors.lastname: Hong
authors.forename: Haifeng
authors.initials: H
authors.lastname: Tang
authors.forename: Siwang
authors.initials: S
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D027983:Aralia / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D012503:Saponins; D014315:Triterpenes