title: Synthesis, antibacterial, antielastase, antiurease and antioxidant activities of new methoxy substitued bis-1,2,4-triazole derivatives.
abstract: The methoxy substitued two novel bis triazole-schiff bases (6 a-b) were synthesized with 4-amino-3,5-diethyl-4H-1,2,4-triazole and various bis-aldehydes. Their amine derivatives prepared by reduced with NaBH(4) (5 a-b). The obtained products 6 a-b and 7 a-b were identified by FT-IR, (1)H-NMR, (13)C-NMR. The bis triazole-schiff bases and amine derivatives were tested for antimicrobial activity using the agar diffusion technique against 11 bacteria. The synthesized compounds (6 a-b and 7 a-b) were screened for their antielastase, antiurease and antioxidant activities. The resuts showed that the synthesized compounds (6 a-b and 7 a-b) had effective antielastase and antiurease activities.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey. baharsokmen@yahoo.com
authors.forename: Bahar Bilgin
authors.initials: BB
authors.lastname: Sokmen
authors.forename: Nurhan
authors.initials: N
authors.lastname: Gumrukcuoglu
authors.forename: Serpil
authors.initials: S
authors.lastname: Ugras
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Ugras
authors.forename: Refiye
authors.initials: R
authors.lastname: Yanardag
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012545:Schiff Bases / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D012545:Schiff Bases; D014230:Triazoles; C045575:1,2,4-triazole; D010196:Pancreatic Elastase; D014510:Urease