title: Development of the human corpus striatum and the presence of nNOS and 5-HT2A receptors.
abstract: This study focussed on the development of the corpus striatum in the fetus, using silver impregnation and immunohistochemistry. For the latter, we looked for nNOS positive cells and 5-HT(2A) receptors positive cells in the corpus striatum during development. During the initial formation of the corpus striatum, there was migration cells of the ganglionic eminence toward the putamen by 15-17 weeks of gestation. Process formation in the neurons started by week 17 and became very complex before term (31/32 weeks of gestation). By 25-27 gestational weeks, the globus pallidus already had two parts and the corpus striatum was similar to the adult in configuration. The nNOS positive cells appeared early (21-23 weeks in gestation) while 5-HT(2A) receptors positive cells were not observed until 31/32 weeks gestation. The number of positive cells in both groups was relatively small. It is anticipated that further developmental changes would occur in the postnatal/neonatal phases.
authors.affiliation: Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou, China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Hu
authors.forename: John A
authors.initials: JA
authors.lastname: Rudd
authors.forename: Marong
authors.initials: M
authors.lastname: Fang
mesh_terms: D019521:Body Patterning / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003342:Corpus Striatum / Q000196:embryology* / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005333:Fetus; D006801:Humans; D008297:Male; D055495:Neurogenesis / Q000502:physiology*; D026602:Nitrergic Neurons / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I / Q000096:biosynthesis / Q000378:metabolism*; D011247:Pregnancy; D044402:Receptor, Serotonin, 5-HT2A / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D052248:Nitric Oxide Synthase Type I