title: Pathogenic alteration in severe burn wounds.
abstract: The present study aims to define the trend of time related changes with local bacterial alteration of bacterial resistance in severe burns in our burn center during a 12-year period. Retrospective analysis of microbiological results on severely burned wounds between 1998 and 2009 was carried out. A study of 3615 microbial isolates was performed. Staphylococcus aureus was the most commonly isolated pathogen (38.2%) followed by A. baumannii (16.2%), Streptococcus viridans (11.4%), Pseudomonas aeruginosa (10.4%), coagulase-negative staphylococci (CNS, 9.2%). The species ratios of S. aureus and A. baumannii increased significantly from 1st to 8th week of hospitalization, while those of Streptococcus viridans, P. aeruginosa and coagulase-negative staphylococci decreased during the same period. Bacterial resistance rates were compared between the periods 1998-2003 and 2004-2009. Vancomycin remained as the most sensitive antibiotic in S. aureus including methicillin-resistant S. aureus (MRSA). It was very likely that the majority of infections caused by Streptococcus viridans, P. aeruginosa and coagulase-negative staphylococci occurred in the early stage of burn course and the majority of infections caused by A. baumannii occurred 4 weeks after admission. The use of different antibiotics was probably the major contributor to these trends.
authors.affiliation: Burn Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Fu
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.forename: DaoFeng
authors.initials: D
authors.lastname: Ben
authors.forename: KaiYang
authors.initials: K
authors.lastname: Lv
authors.forename: ShiHui
authors.initials: S
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: HongTai
authors.initials: H
authors.lastname: Tang
authors.forename: DaSheng
authors.initials: D
authors.lastname: Cheng
authors.forename: Bing
authors.initials: B
authors.lastname: Ma
authors.forename: GuangYi
authors.initials: G
authors.lastname: Wang
authors.forename: ShiChu
authors.initials: S
authors.lastname: Xiao
authors.forename: GuangQing
authors.initials: G
authors.lastname: Wang
authors.forename: ZhaoFan
authors.initials: Z
authors.lastname: Xia
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D002056:Burns / Q000382:microbiology*; D005260:Female; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents