title: Collaboration between PcG proteins and MLL fusions in Leukemogenesis: an emerging paradigm.
abstract: PcG and TrxG proteins mostly with opposite transcriptional activities play key roles in normal and malignant development. In this issue of Cancer Cell, Tan et al. report an unexpected collaboration between CBX8 and MLL-AF9 in leukemia, revealing a far more complicated functional crosstalk between these master epigenetic regulators in oncogenesis.
authors.affiliation: Leukaemia and Stem Cell Biology Group, Department of Haematological Medicine, Rayne Institute, King's College London, SE5 9NU London, UK.
authors.forename: Bernd B
authors.initials: BB
authors.lastname: Zeisig
authors.forename: Mari-Francis
authors.initials: MF
authors.lastname: Arteaga
authors.forename: Cecile
authors.initials: C
authors.lastname: Thirant
authors.forename: Chi Wai Eric
authors.initials: CW
authors.lastname: So