title: Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning.
abstract: One of the archetypal task manipulations known to depend on frontal-lobe function is reversal learning, where a dominant response must be overridden due to changes in the contingencies relating stimuli, responses, and environmental feedback. Previous studies have indicated that the lateral prefrontal cortex (LPFC), the lateral orbitofrontal cortex (LOFC), the anterior cingulate cortex (ACC), and the caudate nucleus (CN) all contribute to reversal learning. However, the exact contributions that they make during this cognitively complex task remain poorly defined. Here, using functional magnetic resonance imaging, we examine which of the cognitive processes that contribute to the performance of a reversal best predicts the pattern of activation within distinct sub-regions of the frontal lobes. We demonstrate that during reversal learning the LOFC is particularly sensitive to the implementation of the reversal, whereas the LPFC is recruited more generally during attentional control. By contrast, the ACC and CN respond when new searches are initiated regardless of whether the previous response is available, whilst medial orbitofrontal cortex (MOFC) activity is correlated with the positive affect of feedback. These results accord well with the hypothesis that distinct components of adaptable behaviour are supported by anatomically distinct components of the executive system.
authors.affiliation: Medical Research Council Cognition and Brain Sciences Unit, Chaucer Road, Cambridge, UK. ahampshi@uwo.ca
authors.forename: Adam
authors.initials: A
authors.lastname: Hampshire
authors.forename: Amir M
authors.initials: AM
authors.lastname: Chaudhry
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Owen
authors.forename: Angela C
authors.initials: AC
authors.lastname: Roberts
mesh_terms: D000328:Adult; D002755:Choice Behavior / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D012193:Reversal Learning / Q000502:physiology*; D012201:Reward; D055815:Young Adult
references.citation: J Neurosci. 2002 Jun 1;22(11):4563-7
references.pmid: 12040063
references.citation: Nat Neurosci. 2009 Jul;12(7):939-45
references.pmid: 19503087
references.citation: Neuron. 2003 Aug 28;39(5):731-3
references.pmid: 12948440
references.citation: Neuron. 2001 Nov 8;32(3):537-51
references.pmid: 11709163
references.citation: J Neurosci. 2003 Oct 22;23(29):9632-8
references.pmid: 14573543
references.citation: J Neurosci. 2007 Apr 25;27(17):4587-97
references.pmid: 17460071
references.citation: Neuron. 2004 Jan 22;41(2):281-92
references.pmid: 14741108
references.citation: J Cell Biochem. 2010 Oct 15;111(3):543-53
references.pmid: 20626031
references.citation: J Cogn Neurosci. 2008 Sep;20(9):1670-86
references.pmid: 18345987
references.citation: Biol Psychiatry. 2009 Jun 1;65(11):966-72
references.pmid: 19217613
references.citation: Eur J Neurosci. 2005 Jul;22(2):513-23
references.pmid: 16045504
references.citation: J Neurosci. 2008 Oct 22;28(43):10972-82
references.pmid: 18945905
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20547-52
references.pmid: 21059901
references.citation: J Cogn Neurosci. 2004 Apr;16(3):463-78
references.pmid: 15072681
references.citation: Brain. 2003 Aug;126(Pt 8):1830-7
references.pmid: 12821528
references.citation: Cereb Cortex. 2003 Oct;13(10):1064-71
references.pmid: 12967923
references.citation: Neuroimage. 2007 Feb 15;34(4):1754-65
references.pmid: 17188518
references.citation: Science. 2008 Jul 18;321(5887):421-2
references.pmid: 18635808
references.citation: Science. 2004 Apr 16;304(5669):452-4
references.pmid: 15087550
references.citation: J Neurosci. 2010 Oct 27;30(43):14552-9
references.pmid: 20980613
references.citation: Nature. 2005 Feb 24;433(7028):873-6
references.pmid: 15729344
references.citation: Neuroimage. 2010 Apr 15;50(3):1313-9
references.pmid: 20056157
references.citation: Neuroreport. 2002 May 7;13(6):885-90
references.pmid: 11997707
references.citation: Cogn Affect Behav Neurosci. 2009 Mar;9(1):103-12
references.pmid: 19246331
references.citation: Trends Cogn Sci. 2004 Apr;8(4):170-7
references.pmid: 15050513
references.citation: Nat Rev Neurosci. 2003 Aug;4(8):662-71
references.pmid: 12894241
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: J Neurosci. 2003 Sep 24;23(25):8771-80
references.pmid: 14507977
references.citation: Neuroimage. 2011 Jan 15;54(2):1432-41
references.pmid: 20850555
references.citation: Cereb Cortex. 2006 Dec;16(12):1679-89
references.pmid: 16436686
references.citation: J Cogn Neurosci. 2000 Jan;12(1):142-62
references.pmid: 10769312
references.citation: Prog Neurobiol. 2008 Nov;86(3):141-55
references.pmid: 18824075
references.citation: Science. 2002 Mar 1;295(5560):1737-40
references.pmid: 11834781
references.citation: J Neurosci. 2009 Jul 1;29(26):8388-95
references.pmid: 19571129
references.citation: Nature. 1996 Mar 7;380(6569):69-72
references.pmid: 8598908
references.citation: J Neurosci. 1997 Dec 1;17(23):9285-97
references.pmid: 9364074
references.citation: Science. 1998 May 1;280(5364):747-9
references.pmid: 9563953
references.citation: J Neurosci. 2004 Aug 25;24(34):7540-8
references.pmid: 15329401
references.citation: Neuropsychologia. 2003;41(2):147-55
references.pmid: 12459213
references.citation: Nat Rev Neurosci. 2005 Sep;6(9):691-702
references.pmid: 16136173
references.citation: J Cogn Neurosci. 2006 Jul;18(7):1198-211
references.pmid: 16839292
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: J Neurosci. 2001 Aug 15;21(16):RC159
references.pmid: 11459880
references.citation: Trends Cogn Sci. 2004 Dec;8(12):539-46
references.pmid: 15556023
references.citation: Exp Brain Res. 1970 Nov 26;11(4):376-86
references.pmid: 4993199
references.citation: Neuroimage. 2003 Jan;18(1):127-42
references.pmid: 12507450
references.citation: Cereb Cortex. 2010 Aug;20(8):1843-52
references.pmid: 19915091
references.citation: Cereb Cortex. 2000 Mar;10(3):308-17
references.pmid: 10731225
references.citation: Science. 2003 Nov 14;302(5648):1181-5
references.pmid: 14615530
references.citation: Cereb Cortex. 1999 Dec;9(8):815-23
references.pmid: 10601000
references.citation: Cereb Cortex. 2011 May;21(5):1155-65
references.pmid: 20923963
references.citation: Nat Neurosci. 2008 Apr;11(4):389-97
references.pmid: 18368045
references.citation: Nat Neurosci. 2001 Jan;4(1):95-102
references.pmid: 11135651
references.citation: Cereb Cortex. 2001 Sep;11(9):837-48
references.pmid: 11532889
references.citation: Neuroimage. 2003 Sep;20(1):351-8
references.pmid: 14527595
references.citation: PLoS One. 2008 Jun 25;3(6):e2520
references.pmid: 18575585