title: Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis.
abstract: Fibrosis can be considered as wound healing that never ceases, and activated fibroblasts (myofibroblasts) probably play a critical role in this unabated tissue repair process. In the setting of renal fibrosis, two central questions remain unanswered: Where do activated myofibroblasts come from; and what mechanism or mechanisms keep them activated? The study by Chen and colleagues addresses the role of platelet-derived growth factor receptor (PDGFR) signaling in the activation of myofibroblasts.
authors.affiliation: Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. vlebleu@bidmc.harvard.edu
authors.forename: Valerie S
authors.initials: VS
authors.lastname: LeBleu
authors.forename: Raghu
authors.initials: R
authors.lastname: Kalluri
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000209:etiology*; D007674:Kidney Diseases / Q000473:pathology*; D058628:Myofibroblasts / Q000473:pathology*; D020286:Pericytes / Q000473:pathology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*; D015427:Reperfusion Injury / Q000473:pathology*; D014517:Ureteral Obstruction / Q000473:pathology*
chemical_list: D017479:Receptors, Platelet-Derived Growth Factor
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