title: Hyperleptinaemia positively correlated with metabolic syndrome in hemodialysis patients.
abstract: OBJECTIVE
  To evaluate the relationship between metabolic syndrome (MetS) and the fasting serum leptin concentration in hemodialysis (HD) patients.
  
  
  METHODS
  Fasting blood samples were obtained from 101 HD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation.
  
  
  RESULTS
  Forty-eight patients (47.5%) had MetS. Serum leptin concentrations were positively correlated with MetS (p<0.001). Serum leptin levels correlated with increasing numbers of MetS criteria in HD patients (p=0.001). Univariate linear regression analysis showed that the pre-HD body weight (p<0.001), waist circumference (p<0.001), body mass index (p=0.001), triglycerides (p=0.003), insulin level (p=0.043), and homeostasis model assessment of insulin resistance (p=0.003) positively correlated with serum leptin levels in HD patients and high-density lipoprotein-cholesterol (p=0.016) negatively correlated with serum leptin levels in HD patients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that pre-HD body weight (R(2)=0.175; p<0.001) was the independent predictor of the fasting serum leptin concentration.
  
  
  CONCLUSIONS
  Fasting serum leptin levels positively correlated with MetS and the pre-HD body weight could influence serum leptin in HD patients.
authors.affiliation: Division of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.
authors.forename: Jen-Pi
authors.initials: JP
authors.lastname: Tsai
authors.forename: Chen-Chi
authors.initials: CC
authors.lastname: Tsai
authors.forename: Hsiang-Man
authors.initials: HM
authors.lastname: Liu
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.forename: Hung-Hsiang
authors.initials: HH
authors.lastname: Liou
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000368:Aged; D001835:Body Weight / Q000502:physiology; D005215:Fasting; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000453:epidemiology* / Q000628:therapy; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D020738:Leptin