title: Thermodynamic remarks on chelating ligands for aluminium related diseases.
abstract: Attention is devoted to the role of chelating agents in the treatment of aluminium related diseases. In fact, in spite of the actions that have drastically reduced the occurrence of dialysis diseases, they so far constitute a cause of great medical concern. Being aluminium chelators strictly related to iron chelators, a comparison is made of the complex formation properties of these two hard metal ions towards ligands characterized by charged oxygen donor groups. Empirical correlations between aluminium(III) and iron(III) complex formation constants, and their behavior are discussed in terms of structural and thermodynamic stabilities. Insertion of proper substituents to enhance the chelator binding capacity is debated on the bases of substituent effects on protonation and complex formation constants.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy. crisponi@unica.it
authors.forename: Guido
authors.initials: G
authors.lastname: Crisponi
authors.forename: Valeria Marina
authors.initials: VM
authors.lastname: Nurchi
mesh_terms: D000465:Algorithms; D000535:Aluminum / Q000737:chemistry* / Q000633:toxicity; D001847:Bone Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D002614:Chelating Agents / Q000737:chemistry* / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D013816:Thermodynamics
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D000535:Aluminum; D007501:Iron