title: A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage.
abstract: Amoxicillin, an antibiotic that is widely prescribed for various infections, is associated with a very low rate of drug-induced liver injury; hepatitis and cholestasis are rare complications. Here we present a case of a 39-year-old woman who was diagnosed with abdominal actinomycosis and received amoxicillin treatment. The patient displayed hepatocellular and bile-duct injury, in addition to elevated levels of liver enzymes. The patient was diagnosed with amoxicillin-induced cholestatic hepatitis. When amoxicillin was discontinued, the patient's symptoms improved and her liver enzyme levels reduced to near to the normal range.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Ju Seung
authors.initials: JS
authors.lastname: Kim
authors.forename: Young Rock
authors.initials: YR
authors.lastname: Jang
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Jin Yong
authors.initials: JY
authors.lastname: Kim
authors.forename: Young Kul
authors.initials: YK
authors.lastname: Jung
authors.forename: Dong Hae
authors.initials: DH
authors.lastname: Chung
authors.forename: Oh Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Yun Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Duck Joo
authors.initials: DJ
authors.lastname: Choi
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000196:Actinomycosis / Q000188:drug therapy; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology; D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
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