title: Constipation-predominant irritable bowel syndrome associated to hyperprolactinemia.
abstract: Irritable bowel syndrome (IBS) is considered to be a physical disorder that mainly affects the bowel and is clinically characterized by lower abdominal pain or discomfort, diarrhea, constipation (or alternating diarrhea/constipation), gas, bloating, and nausea. According to recent studies, it appears that there is an association with increased prolactin levels in patients suffering from IBS. We report a rare case of regression of IBS symptoms (constipation type) in a 16-year-old female adolescent after receiving cabergoline for treating hyperprolactinemia due to pituitary macroadenoma. Our hypothesis is that increased prolactin levels, for instance due to a pituitary adenoma, may suppress prolactin-releasing peptide release and lead to a reverse feedback interaction, consequently resulting in oversecretion of cholecystokinin, inducing the development of IBS.
authors.affiliation: Gastrointestinal Endoscopy Department, Argos Hospital, Argos, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Seretis
authors.forename: F
authors.initials: F
authors.lastname: Seretis
authors.forename: N
authors.initials: N
authors.lastname: Liakos
authors.forename: A
authors.initials: A
authors.lastname: Pappas
authors.forename: D
authors.initials: D
authors.lastname: Keramidaris
authors.forename: S
authors.initials: S
authors.lastname: Gourgiotis
authors.forename: N
authors.initials: N
authors.lastname: Salemis
authors.forename: E
authors.initials: E
authors.lastname: Lagoudianakis
references.citation: J Trop Pediatr. 2004 Feb;50(1):37-40
references.pmid: 14984168
references.citation: Endocrinology. 2001 May;142(5):2032-8
references.pmid: 11316770
references.citation: Peptides. 1994;15(4):731-55
references.pmid: 7937354
references.citation: Dev Immunol. 2001;8(3-4):319-30
references.pmid: 11785680
references.citation: Rev Esp Enferm Dig. 2010 Nov;102(11):637-47
references.pmid: 21142384
references.citation: Gastroenterology. 1983 Jul;85(1):17-21
references.pmid: 6303889
references.citation: World J Gastroenterol. 2008 Aug 21;14(31):4889-96
references.pmid: 18756596
references.citation: Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1275-80
references.pmid: 16874932
references.citation: Endocrinology. 2002 Feb;143(2):360-7
references.pmid: 11796487
references.citation: Lancet. 1973 Jan 6;1(7793):1-3
references.pmid: 4118538
references.citation: Physiol Behav. 2001 Nov-Dec;74(4-5):669-82
references.pmid: 11790430
references.citation: BMC Cancer. 2004 Dec 23;4:97
references.pmid: 15617576
references.citation: Digestion. 2008;78(2-3):72-6
references.pmid: 18948690
references.citation: J Neuroendocrinol. 1992 Apr;4(2):149-52
references.pmid: 21554590
references.citation: Brain Res. 1999 Mar 20;822(1-2):276-9
references.pmid: 10082910
references.citation: Am J Physiol. 1995 Mar;268(3 Pt 1):G431-42
references.pmid: 7534993
references.citation: Gut. 1988 Sep;29(9):1236-43
references.pmid: 3197998