title: Effectiveness of an informational video method to improve enrollment and retention of a pediatric cohort.
abstract: OBJECTIVE
  The Environmental Determinants of Diabetes in the Young (TEDDY), a multinational epidemiological study, is designed to identify environmental exposures triggering autoimmunity and type 1 diabetes (T1D) in children at increased genetic risk. The objective of this analysis was to evaluate the use of an informational video in the enrollment and retention of eligible participants at the Colorado TEDDY clinical center.
  
  
  METHODS
  Eligible participants were divided into two groups based on the inclusion of the video in the enrollment materials: the No-Video Group (n=449) did not receive the video and were contacted between 7/1/07 and 6/30/08. The Video Group (n=494) received the video and were contacted between 7/1/08 and 6/30/09. Multiple logistic regression compared the enrollment rates (percent of eligible subjects deciding to enroll) of those who received the video compared to those who did not. Kaplan-Meier survival analysis and a multivariate Cox proportional hazards model compared the differences in study retention, as defined by active participation fifteen months after the baseline visit at three months of age.
  
  
  RESULTS
  Both groups were demographically similar. The enrollment rate was significantly higher for the Video Group (56.9%) compared to the No-Video Group (49.9%). Differences remained significant with adjustment for other known factors. A difference in retention between the two groups was not observed.
  
  
  CONCLUSIONS
  Methods and materials increasing understanding and more accurately informing participants of what is involved in participation may increase enrollment in a prospective observational study.
authors.affiliation: University of Colorado Denver, The Barbara Davis Center for Childhood Diabetes 1775 Aurora Court, Campus Box F-527, Aurora, CO 80045, United States. patricia.gesualdo@ucdenver.edu
authors.forename: Patricia
authors.initials: P
authors.lastname: Gesualdo
authors.forename: Lisa
authors.initials: L
authors.lastname: Ide
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
authors.forename: Judith
authors.initials: J
authors.lastname: Baxter
mesh_terms: D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening / Q000379:methods*; D019370:Observation / Q000379:methods; D018579:Patient Selection; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014741:Video Recording / Q000706:statistics & numerical data*; D055815:Young Adult
references.citation: Arch Dis Child. 2006 Feb;91(2):112-6
references.pmid: 16246853
references.citation: J Am Acad Child Adolesc Psychiatry. 2004 Aug;43(8):1037-45
references.pmid: 15266200
references.citation: Anesthesiology. 2003 Mar;98(3):603-8
references.pmid: 12606901
references.citation: Patient Educ Couns. 1997 Mar;30(3):239-45
references.pmid: 9104380
references.citation: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD003717
references.pmid: 18254029
references.citation: J Am Med Inform Assoc. 1998 May-Jun;5(3):245-56
references.pmid: 9609494
references.citation: Nurs Res. 2009 Mar-Apr;58(2):135-9
references.pmid: 19289935
references.citation: Pediatr Diabetes. 2011 May;12(3 Pt 1):165-71
references.pmid: 21029290
references.citation: JAMA. 2004 Oct 6;292(13):1593-601
references.pmid: 15467062
references.citation: J Thorac Oncol. 2008 Jan;3(1):23-9
references.pmid: 18166837
references.citation: Pediatr Diabetes. 2007 Oct;8(5):286-98
references.pmid: 17850472
references.citation: Breast Cancer Res Treat. 2009 Sep;117(2):339-47
references.pmid: 19152024