title: [Clinical characteristics of Rett Syndrome].
abstract: BACKGROUND
  Rett Syndrome is a neurodevelopmental disorder, one of the least commonly occurring autism spectrum disorders (ASD),affecting mainly females.
  
  
  OBJECTIVE
  To describe features and molecular specificities of Rett syndrome.
  
  
  METHODS
  To identify articles for this review, a Pubmed search was conducted using the following keywords: Rett syndrome, regression,mutation, stereotypes.
  
  
  RESULTS
  This syndrome is characterized by cognitive impairment,communication dysfunction, stereotypic movement disorder, and growth failure. It is generally caused by mutations in the MECP2 gene. Rett Syndrome has a prevalence ranging from 10-20 000 females. Specific treatment is not available, but patients need a careful planning for long-term care, with multidisciplinary approaches.
authors.affiliation: Service de Pedopsychiatrie, Hopital Razi, Manouba.
authors.forename: Zeineb
authors.initials: Z
authors.lastname: Abbes
authors.forename: Asma
authors.initials: A
authors.lastname: Bouden
authors.forename: Soumaya
authors.initials: S
authors.lastname: Halayem
authors.forename: Sami
authors.initials: S
authors.lastname: Othman
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bechir Halayem
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis; D015518:Rett Syndrome / Q000175:diagnosis* / Q000235:genetics