title: Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion.
abstract: Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.
authors.affiliation: Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
authors.forename: Tjøstil
authors.initials: T
authors.lastname: Vlaar
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Anass
authors.initials: A
authors.lastname: Znabet
authors.forename: Elwin
authors.initials: E
authors.lastname: Janssen
authors.forename: Frans J J
authors.initials: FJ
authors.lastname: de Kanter
authors.forename: Bert U W
authors.initials: BU
authors.lastname: Maes
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C569979:4-aminophthalazin-1(2H)-one; D009570:Nitriles; D010793:Phthalazines; D010165:Palladium