title: NMDA receptors at the endplate of rat skeletal muscles: precise postsynaptic localization.
abstract: In this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction.
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan 420111, Russia. artur57@gmail.com
authors.forename: Artem I
authors.initials: AI
authors.lastname: Malomouzh
authors.forename: Leniz F
authors.initials: LF
authors.lastname: Nurullin
authors.forename: Svetlana S
authors.initials: SS
authors.lastname: Arkhipova
authors.forename: Evgeny E
authors.initials: EE
authors.lastname: Nikolsky
mesh_terms: D000818:Animals; D009045:Motor Endplate / Q000737:chemistry* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000378:metabolism; D017729:Presynaptic Terminals / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*; D012508:Sarcolemma / Q000737:chemistry / Q000378:metabolism; D055366:Synaptic Potentials / Q000502:physiology
chemical_list: C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate