title: [Effects of combined enteral nutrition support on hemorrheologic parameters and the level of inflammatory factors in rabbits with severe acute pancreatitis].
abstract: OBJECTIVE
  To explore the effects of combined enteral nutrition (CEN) on the hemorheologic parameters and the changing levels of inflammatory factors in an animal model of severe acute pancreatitis (SAP).
  
  
  METHODS
  The experimental animals were divided randomly into 3 groups, i.e. early enteral nutrition (EEN) group, CEN group and parenteral nutrition(PN)group (n = 20 each). Enteral nutrition was administered to the EEN and CEN group animals at 24 h and 72 h post-modeling respectively. The PN group animals were supported by parenteral nutrition all time. Hemorrheologic indices of all experimental animals were examined on Days 1, 3 and 7 post-modeling. And the inflammatory factors were examined on Days 1 and 7.
  
  
  RESULTS
  Compared with the EEN and PN groups, some hemorrheologic indices of the CEN group decreased significantly (P < 0.05) on Day 7 post-modeling. They included blood sedimentation, hematocrit (HCT), whole blood high-cut reduction viscosity and whole blood low-cut reduction viscosity. As compared within the CEN group, each hemorrheologic index was lower on Day 7 than that on Day 1 (P < 0.05). Except for whole blood high-cut reduction viscosity and erythrocyte aggregation index in the EEN group after a 7-day nutrition support, there was no significant change for all hemorrheologic indices in the PN group. As to the level of inflammatory factors, the values of interleukin 8 (IL-8) and tumor necrosis factor-α (TNF-α) in the CEN group were lower than those in the PN group on Day 7 post-modeling (P < 0.05). The values of IL-8 and IL-6 in the CEN group were lower than those in the EEN group on the same day (P < 0.05). As compared within the CEN group, the values of IL-6 and TNF-α were lower on Day 7 than those on Day 1 post-modeling (P < 0.05).
  
  
  CONCLUSIONS
  The modulatory mechanism of EN over SAP should be achieved by correcting hemorrheologic index change and lowering the level of inflammatory factors. A proper timing of EN is probably the most optimal nutrition support mode of SAP therapy.
authors.affiliation: Department of Hepatobiliary & Pancreatic Surgery, Huzhou Central Hospital, Huzhou, China. yan_qiang@tom.com
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Ni
authors.forename: Guo-lei
authors.initials: GL
authors.lastname: Zhang
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Yuan
authors.forename: Jin-liang
authors.initials: JL
authors.lastname: Ping
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Jin
mesh_terms: D000818:Animals; D004750:Enteral Nutrition; D016209:Interleukin-8 / Q000378:metabolism; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000378:metabolism*; D010288:Parenteral Nutrition; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha