title: Bioactive composite for keratoprosthesis skirt.
abstract: In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e. 45S5, S53P4 and 1-98) and one slowly resorbing glass, FL107, with two different forms (i.e. particles and porous glass structures) were employed in the fabrication of specimens. In in vitro studies, the dissolution behaviour in simulated aqueous humour, compressive properties, and pore formation of the composites were investigated. According to the results, FL107 dissolved very slowly (2.4% of the initial glass content in three weeks); thus, the pore formation of the FL107 composite was also observed to be restricted. The dissolution rates of the bioactive glass-PMMA composites were greater (12%-17%). These faster dissolving bioactive glass particles caused some porosity on the outermost surfaces of the composite. The slight surface porosity was also confirmed by a decrease in compressive properties. During six weeks' in vitro dissolution, the compressive strength of the test specimens containing particles decreased by 22% compared to values in dry conditions (90-107 MPa). These results indicate that the bioactive composites could be stable synthetic candidates for a keratoprosthesis skirt in the treatment of severely damaged or diseased cornea.
authors.affiliation: Turku Clinical Biomaterials Centre-TCBC, Department of Biomaterials Science, University of Turku, Itäinen Pitkäkatu 4 B, FI-20520 Turku, Finland. kaisa.laattala@utu.fi
authors.forename: Kaisa
authors.initials: K
authors.lastname: Laattala
authors.forename: Reeta
authors.initials: R
authors.lastname: Huhtinen
authors.forename: Mervi
authors.initials: M
authors.lastname: Puska
authors.forename: Hanna
authors.initials: H
authors.lastname: Arstila
authors.forename: Leena
authors.initials: L
authors.lastname: Hupa
authors.forename: Minna
authors.initials: M
authors.lastname: Kellomäki
authors.forename: Pekka K
authors.initials: PK
authors.lastname: Vallittu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003315:Cornea; D005898:Glass / Q000737:chemistry; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate / Q000737:chemistry; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate