title: Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
abstract: New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.
authors.affiliation: Laboratory of Glycochemistry and Asymmetric Synthesis, Swiss Federal Institute of Technology (EPFL), Batochime, CH-1015 Lausanne, Switzerland.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Dal Bello
authors.forename: Michele
authors.initials: M
authors.lastname: Cea
authors.forename: Aimable
authors.initials: A
authors.lastname: Nahimana
authors.forename: Dominique
authors.initials: D
authors.lastname: Aubry
authors.forename: Anna
authors.initials: A
authors.lastname: Garuti
authors.forename: Giulia
authors.initials: G
authors.lastname: Motta
authors.forename: Eva
authors.initials: E
authors.lastname: Moran
authors.forename: Floriana
authors.initials: F
authors.lastname: Fruscione
authors.forename: Paolo
authors.initials: P
authors.lastname: Pronzato
authors.forename: Francesco
authors.initials: F
authors.lastname: Grossi
authors.forename: Franco
authors.initials: F
authors.lastname: Patrone
authors.forename: Alberto
authors.initials: A
authors.lastname: Ballestrero
authors.forename: Marc
authors.initials: M
authors.lastname: Dupuis
authors.forename: Bernard
authors.initials: B
authors.lastname: Sordat
authors.forename: Kaspar
authors.initials: K
authors.lastname: Zimmermann
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Loretan
authors.forename: Markus
authors.initials: M
authors.lastname: Wartmann
authors.forename: Michel A
authors.initials: MA
authors.lastname: Duchosal
authors.forename: Alessio
authors.initials: A
authors.lastname: Nencioni
authors.forename: Pierre
authors.initials: P
authors.lastname: Vogel
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D019169:Jurkat Cells; D009369:Neoplasms / Q000188:drug therapy; D012255:Ribitol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D012255:Ribitol