title: Identification of human salivary transglutaminases.
abstract: Transglutaminases (TGs) expression and enzymatic activities in human saliva were investigated. Specific antibodies showed the co-existence of TG1, TG2, TG3 and TG4. TG2 and TG3 were found in native and multiple proteolytic forms. Our data indicate that TG1 and TG2 isoenzymes are highly active with the major activity attributed to TG1. These findings pave the way for future studies on the physiological role of TG in the oral cavity and the potential impact of their deregulation in TG-associated oral diseases.
authors.affiliation: CovalAb, Research Department, 11 Avenue Albert Einstein, 69100 Villeurbanne, Lyon, France. m.perez@aston.ac.uk
authors.forename: Mileidys
authors.initials: M
authors.lastname: Perez Alea
authors.forename: Vincent
authors.initials: V
authors.lastname: Thomas
authors.forename: Guillaume
authors.initials: G
authors.lastname: Martin
authors.forename: Saïd
authors.initials: S
authors.lastname: El Alaoui
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry; D005260:Female; D019204:GTP-Binding Proteins; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000737:chemistry; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012463:Saliva / Q000201:enzymology*; D011503:Transglutaminases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010446:Peptide Fragments; C418702:transglutaminase 4; D000091345:Protein Glutamine gamma Glutamyltransferase 2; C498712:TGM3 protein, human; D011503:Transglutaminases; C105804:transglutaminase 1; D019204:GTP-Binding Proteins