title: Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates.
abstract: Bisphosphonates have a long history in the treatment of osteoporosis and bone-related disease. This review focuses on the use of a specific nonaminobisphosphonate, clodronate, which appears to be much better tolerated than other bisphosphonates and free of high-risk contraindications. Specifically, this paper reviews its use in the prevention of osteoporosis in postmenopausal women, taking into account its tolerability profile and recent safety issues arising regarding the use of bisphosphonates.
authors.affiliation: Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy. mamuratore@libero.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muratore
authors.forename: Eugenio
authors.initials: E
authors.lastname: Quarta
authors.forename: Antonella
authors.initials: A
authors.lastname: Grimaldi
authors.forename: Fabio
authors.initials: F
authors.lastname: Calcagnile
authors.forename: Laura
authors.initials: L
authors.lastname: Quarta
mesh_terms: D004002:Clodronic Acid / Q000009:adverse effects* / Q000191:economics / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000517:prevention & control*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D004164:Diphosphonates; D004002:Clodronic Acid
references.citation: Age Ageing. 2005 Nov;34(6):633-6
references.pmid: 16267191
references.citation: N Engl J Med. 2001 Feb 1;344(5):333-40
references.pmid: 11172164
references.citation: Arch Intern Med. 2004 May 24;164(10):1108-12
references.pmid: 15159268
references.citation: N Engl J Med. 2007 May 3;356(18):1895-6
references.pmid: 17476024
references.citation: Clin Drug Investig. 2011;31(1):43-50
references.pmid: 20932069
references.citation: Osteoporos Int. 2007 Aug;18(8):1033-46
references.pmid: 17323110
references.citation: J Support Oncol. 2007 Nov-Dec;5(10):475-82
references.pmid: 18240669
references.citation: Minerva Med. 2003 Oct;94(5):353-7
references.pmid: 14973430
references.citation: Clin Drug Investig. 2009;29(6):359-79
references.pmid: 19432497
references.citation: Am J Med. 1997 Feb 17;102(2A):43-9
references.pmid: 9217586
references.citation: Rheumatol Int. 2009 Dec;30(2):213-21
references.pmid: 19430791
references.citation: Crit Rev Oncol Hematol. 2007 Dec;64(3):198-207
references.pmid: 17855108
references.citation: Curr Med Res Opin. 2008 May;24(5):1337-44
references.pmid: 18380910
references.citation: J Oral Maxillofac Surg. 2004 May;62(5):527-34
references.pmid: 15122554
references.citation: J Rheumatol. 2000 Jun;27(6):1477-83
references.pmid: 10852274
references.citation: Adv Ther. 2010 May;27(5):314-20
references.pmid: 20526703
references.citation: Bone. 2003 Oct;33(4):575-81
references.pmid: 14555261
references.citation: Br J Pharmacol. 1999 Feb;126(4):903-10
references.pmid: 10193770
references.citation: N Engl J Med. 2007 May 3;356(18):1809-22
references.pmid: 17476007
references.citation: Am J Med. 2003 Aug 15;115(3):209-16
references.pmid: 12947959
references.citation: Osteoporos Int. 2010 May;21(5):837-46
references.pmid: 19657689
references.citation: N Engl J Med. 2002 Feb 28;346(9):642
references.pmid: 11870240
references.citation: Inflammation. 2004 Feb;28(1):15-21
references.pmid: 15072226
references.citation: J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75
references.pmid: 16243172
references.citation: Bone. 1998 May;22(5):577-82
references.pmid: 9600795
references.citation: Clin Ther. 2004 Feb;26(2):245-56
references.pmid: 15038947
references.citation: G Ital Med Lav Ergon. 2000 Oct-Dec;22(4):328-31
references.pmid: 11284157
references.citation: Lancet. 1980 May 17;1(8177):1043-7
references.pmid: 6103389
references.citation: J Bone Miner Res. 2007 Oct;22(10):1479-91
references.pmid: 17663640
references.citation: Clin Ther. 2005 Apr;27(4):361-76
references.pmid: 15922811
references.citation: Ann Pharmacother. 1993 Sep;27(9 Suppl):S1-24
references.pmid: 8400462
references.citation: J Dent Res. 2006 Aug;85(8):757-60
references.pmid: 16861295
references.citation: JAMA. 1999 Oct 13;282(14):1344-52
references.pmid: 10527181
references.citation: Int J Cardiol. 2010 Jul 23;142(3):213-7
references.pmid: 20051297
references.citation: J Bone Miner Res. 2004 May;19(5):728-36
references.pmid: 15068495
references.citation: J Bone Miner Res. 1995 May;10(5):697-703
references.pmid: 7639104
references.citation: Clin Pharmacokinet. 2005;44(6):551-70
references.pmid: 15932344
references.citation: Osteoporos Int. 2009 May;20(5):811-7
references.pmid: 19002369
references.citation: Osteoporos Int. 2004 Oct;15(10):792-8
references.pmid: 15071723
references.citation: Expert Opin Pharmacother. 2002 Nov;3(11):1643-56
references.pmid: 12437497
references.citation: Bone. 1996 Feb;18(2):179-84
references.pmid: 8833212
references.citation: Prescrire Int. 2011 Apr;20(115):96-7
references.pmid: 21648212
references.citation: Arthritis Res Ther. 2010;12(1):R30
references.pmid: 20170505
references.citation: Bone. 2001 May;28(5):465-73
references.pmid: 11344045
references.citation: Eur Rev Med Pharmacol Sci. 2004 Mar-Apr;8(2):97-102
references.pmid: 15267123
references.citation: Arch Oral Biol. 2000 Sep;45(9):787-95
references.pmid: 10869492
references.citation: Br J Pharmacol. 2000 Aug;130(7):1646-54
references.pmid: 10928970
references.citation: J Clin Endocrinol Metab. 2005 May;90(5):2787-93
references.pmid: 15728213
references.citation: J Bone Miner Res. 2007 Jan;22(1):135-41
references.pmid: 17042717
references.citation: Drugs Aging. 2004;21(14):949-62
references.pmid: 15554753
references.citation: JAMA. 1998 Dec 23-30;280(24):2077-82
references.pmid: 9875874
references.citation: Minerva Med. 2001 Aug;92(4):251-68
references.pmid: 11535969
references.citation: Reumatismo. 2009 Oct-Dec;61(4):260-84
references.pmid: 20143003
references.citation: Pain. 2001 Apr;91(3):269-275
references.pmid: 11275384
references.citation: Osteoporos Int. 2010 Jun;21 Suppl 2:S407-13
references.pmid: 20464374
references.citation: Osteoporos Int. 2006;17(6):914-21
references.pmid: 16538553
references.citation: Osteoporos Int. 2000;11(1):83-91
references.pmid: 10663363
references.citation: Inflamm Res. 2000 Aug;49(8):424-33
references.pmid: 11028760
references.citation: Ann Rheum Dis. 2006 May;65(5):654-61
references.pmid: 16339289
references.citation: Bone. 1993 Mar-Apr;14(2):137-41
references.pmid: 8334031