title: In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL.
abstract: The combination of gene therapy and chemotherapy may increase the therapeutic efficacy in the treatment of patients. In this work, the anti-cancer drug Dox and therapeutic gene pTRAIL-loaded host-guest co-delivery system was assayed for the possibility of in vivo synergistically treating tumors. The introduced Dox could act as an auxiliary component to human tumor necrosis factor-related apoptosis-inducing ligand-encoding plasmid gene pTRAIL. Such delivery system possessed the good ability of in vivo retention of chemotherapeutic drugs, achieved good therapeutic effects in the inhibition of tumor growth and significantly prolonged the survival time of tumor-bearing mice. With the efficient ability to co-deliver drug and gene, such host-guest assembly should have great potential applications in cancer therapy.
authors.affiliation: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Fan
authors.forename: Qi-Da
authors.initials: QD
authors.lastname: Hu
authors.forename: Fu-Jian
authors.initials: FJ
authors.lastname: Xu
authors.forename: Wen-Quan
authors.initials: WQ
authors.lastname: Liang
authors.forename: Gu-Ping
authors.initials: GP
authors.lastname: Tang
authors.forename: Wan-Tai
authors.initials: WT
authors.lastname: Yang
mesh_terms: D000218:Adamantane / Q000737:chemistry; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010957:Plasmids / Q000235:genetics*; D011094:Polyethyleneimine / Q000737:chemistry; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics* / Q000627:therapeutic use*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; D047392:beta-Cyclodextrins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D004317:Doxorubicin; D011094:Polyethyleneimine; C031215:betadex; D000218:Adamantane