title: Using three legacy measures to develop a health-related quality of life tool for young adult survivors of childhood cancer.
abstract: BACKGROUND
  Little attention has been paid to selecting and developing health-related quality of life (HRQOL) measurement tools for young adult survivors of childhood cancer (YASCC). The primary purpose of this study was to develop a HRQOL tool for YASCC based on three legacy instruments.
  
  
  METHODS
  Data collected from 151 YASCC were analyzed. HRQOL was measured using the Medical Outcomes Study SF-36, Quality of Life in Adult Cancer Survivors, and Quality of Life-Cancer Survivor. We used the following stages to develop our HRQOL tool: mapping items from three instruments into a common HRQOL construct, checking dimensionality using confirmatory factor analyses (CFA), and equating items using Rasch modeling.
  
  
  RESULTS
  We assigned 123 items to a HRQOL construct comprised of six generic and eight survivor-specific domains. CFA retained 107 items that meet the assumptions of unidimensionality and local independence. Rasch analysis retained 68 items that satisfied the indices of information-weighted/outlier-sensitive fit statistic mean square. However, items in most domains possess relatively easy measurement properties, whereas YASCC's underlying HRQOL was on the middle to higher levels.
  
  
  CONCLUSIONS
  Psychometric properties of the established tool for measuring HRQOL of YASCC were not satisfied. Future studies need to refine this tool, especially adding more challenging items.
authors.affiliation: Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA. ichuang@ufl.edu
authors.forename: I-Chan
authors.initials: IC
authors.lastname: Huang
authors.forename: Gwendolyn P
authors.initials: GP
authors.lastname: Quinn
authors.forename: Pey-Shan
authors.initials: PS
authors.lastname: Wen
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Shenkman
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Revicki
authors.forename: Kevin
authors.initials: K
authors.lastname: Krull
authors.forename: Zhushan
authors.initials: Z
authors.lastname: Li
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Shearer
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000367:Age Factors; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D009369:Neoplasms / Q000523:psychology*; D010147:Pain Measurement; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D012042:Registries; D013315:Stress, Psychological; D017741:Survivors / Q000523:psychology*; D013997:Time Factors; D055815:Young Adult
references.citation: J Natl Cancer Inst. 2008 Nov 5;100(21):1530-41
references.pmid: 18957678
references.citation: Qual Health Res. 2003 Feb;13(2):227-46
references.pmid: 12643030
references.citation: Semin Oncol. 2009 Oct;36(5):468-77
references.pmid: 19835742
references.citation: Psychooncology. 2003 Mar;12(2):141-52
references.pmid: 12619146
references.citation: Qual Life Res. 2007;16 Suppl 1:5-18
references.pmid: 17375372
references.citation: Qual Health Res. 2005 Oct;15(8):1055-73
references.pmid: 16221879
references.citation: Int J Hematol. 2010 Jun;91(5):865-76
references.pmid: 20467848
references.citation: Qual Life Res. 2010 Mar;19(2):207-18
references.pmid: 20058086
references.citation: Psychooncology. 2006 Jan;15(1):31-43
references.pmid: 15751002
references.citation: Cancer Nurs. 2010 Jan-Feb;33(1):E18-24
references.pmid: 19926973
references.citation: Med Pediatr Oncol. 1997 Dec;29(6):582-8
references.pmid: 9324350
references.citation: JAMA. 2007 Jun 27;297(24):2705-15
references.pmid: 17595271
references.citation: Int J Hematol. 2010 Jul;92(1):95-104
references.pmid: 20577841
references.citation: Eur J Cancer. 2007 Jan;43(1):122-30
references.pmid: 16987653
references.citation: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references.pmid: 19474385
references.citation: J Clin Oncol. 1997 Feb;15(2):547-56
references.pmid: 9053476
references.citation: Support Care Cancer. 2002 Nov;10(8):579-600
references.pmid: 12436217
references.citation: Acta Paediatr. 2007 Sep;96(9):1265-8
references.pmid: 17718778
references.citation: Qual Life Res. 2001;10(4):319-29
references.pmid: 11763245
references.citation: J Adv Nurs. 2009 Oct;65(10):2131-41
references.pmid: 19674170
references.citation: N Engl J Med. 2006 Oct 12;355(15):1572-82
references.pmid: 17035650
references.citation: J Pain Symptom Manage. 2007 Dec;34(6):657-65
references.pmid: 17618079
references.citation: J Clin Oncol. 2006 Jun 1;24(16):2527-35
references.pmid: 16735705
references.citation: Qual Life Res. 2007 Sep;16(7):1211-20
references.pmid: 17624814
references.citation: Med Care. 2000 Sep;38(9 Suppl):II28-42
references.pmid: 10982088
references.citation: Psychooncology. 2004 Oct;13(10):689-99
references.pmid: 15386645
references.citation: Sleep. 2008 Feb;31(2):271-81
references.pmid: 18274275
references.citation: Qual Life Res. 2005 May;14(4):1007-23
references.pmid: 16041897
references.citation: Eur J Cancer. 2002 Feb;38(3):339-48
references.pmid: 11818198
references.citation: Med Care. 1992 Jun;30(6):473-83
references.pmid: 1593914
references.citation: Blood. 2005 Jun 1;105(11):4215-22
references.pmid: 15701723
references.citation: J Clin Epidemiol. 2002 Jan;55(1):32-40
references.pmid: 11781120
references.citation: Qual Health Res. 2009 Mar;19(3):312-22
references.pmid: 19224875
references.citation: Support Care Cancer. 2005 Jan;13(1):49-56
references.pmid: 15565275
references.citation: Eur J Cancer. 1996 Jul;32A(8):1354-8
references.pmid: 8869099
references.citation: J Psychosoc Oncol. 2006;24(3):125-45
references.pmid: 17088244
references.citation: Med Care. 2003 May;41(5):582-92
references.pmid: 12719681
references.citation: Semin Radiat Oncol. 2003 Jul;13(3):176-81
references.pmid: 12903007
references.citation: Cancer. 1998 Jul 1;83(1):69-75
references.pmid: 9655295
references.citation: Qual Life Res. 2007;16 Suppl 1:95-108
references.pmid: 17530450
references.citation: Health Qual Life Outcomes. 2010 Mar 06;8:25
references.pmid: 20205922
references.citation: J Surg Oncol. 2000 Apr;73(4):192-7
references.pmid: 10797331
references.citation: Qual Life Res. 2007 May;16(4):647-60
references.pmid: 17334829
references.citation: Qual Life Res. 1995 Dec;4(6):523-31
references.pmid: 8556012
references.citation: J Pediatr Oncol Nurs. 2008 May-Jun;25(3):164-74
references.pmid: 18353751
references.citation: Pediatr Hematol Oncol. 1997 Nov-Dec;14(6):513-24
references.pmid: 9383804
references.citation: J Pediatr Hematol Oncol. 1997 May-Jun;19(3):220-5
references.pmid: 9201144
references.citation: Chronic Illn. 2007 Dec;3(4):278-95
references.pmid: 18083682