title: A hybrid form of retinopathy of prematurity.
abstract: OBJECTIVE
  To study a hybrid pattern of retinopathy of prematurity (ROP) demonstrating both ridge tissue (simulating staged ROP) and flat neovascularisation (simulating aggressive posterior retinopathy of prematurity (APROP)) in the same eye.
  
  
  METHODS
  Retrospective chart review from January 2006 to June 2010. We reviewed the retinal drawings and Retcam images for a hybrid pattern of ROP, that is, presence of ridge tissue (characteristic of staged ROP) along with flat neovascular syncytium (characteristic of APROP) in the same eye.
  
  
  RESULTS
  28 eyes of 18 infants had hybrid characteristics. All eyes had severe plus disease, flat new vessels at the junction of the vascular and avascular retina and ridge tissue at variable locations. Three patterns were noted: I Ridge at the junction of vascular and avascular retina (14 (50%) eyes); II Ridge in the vascularised posterior retina (10 (35.71%) eyes); III Ill-defined ridge close to the optic disc, with mat-like fibrous proliferation into the vitreous (4 (14.29%) eyes). After confluent laser photocoagulation, we observed favourable outcome in 92.3% eyes with pattern I, 100% eyes with pattern II and 25% eyes with pattern III disease.
  
  
  CONCLUSIONS
  Some eyes with ROP may have abnormal neovascularisation resembling both APROP and classical staged ROP. It is difficult to characterise these eyes according to the international classification of ROP. However, the presence of plus disease should serve as guide to treatment.
authors.affiliation: Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sanghi
authors.forename: Mangat R
authors.initials: MR
authors.lastname: Dogra
authors.forename: Mohit
authors.initials: M
authors.lastname: Dogra
authors.forename: Deeksha
authors.initials: D
authors.lastname: Katoch
authors.forename: Amod
authors.initials: A
authors.lastname: Gupta
mesh_terms: D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation; D011379:Prognosis; D012160:Retina / Q000473:pathology* / Q000601:surgery; D015861:Retinal Neovascularization / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery; D012171:Retinal Vessels / Q000002:abnormalities*; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000601:surgery; D042262:Retinoscopy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014792:Visual Acuity