title: Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches.
abstract: Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA. kefalov@wustl.edu
authors.forename: Vladimir J
authors.initials: VJ
authors.lastname: Kefalov
mesh_terms: D000818:Animals; D006801:Humans; D055355:Opsins / Q000378:metabolism*; D017949:Retinal Cone Photoreceptor Cells / Q000166:cytology / Q000502:physiology*; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology / Q000502:physiology*; D012172:Retinaldehyde / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*
chemical_list: D055355:Opsins; D012172:Retinaldehyde
references.citation: Pflugers Arch. 2007 Aug;454(5):805-19
references.pmid: 17226052
references.citation: Nature. 1975 Dec 11;258(5535):523-6
references.pmid: 1196384
references.citation: Physiol Rev. 2001 Jan;81(1):117-151
references.pmid: 11152756
references.citation: Photochem Photobiol. 1996 May;63(5):595-600
references.pmid: 8628750
references.citation: Cell Mol Life Sci. 1998 Dec;54(12):1299-315
references.pmid: 9893707
references.citation: J Physiol. 1980 Dec;309:591-621
references.pmid: 6788941
references.citation: Biochem J. 1992 Aug 1;285 ( Pt 3):907-13
references.pmid: 1497628
references.citation: J Physiol. 2005 Oct 1;568(Pt 1):83-95
references.pmid: 15994181
references.citation: J Gen Physiol. 1996 Oct;108(4):333-40
references.pmid: 8894981
references.citation: J Gen Physiol. 2000 Aug;116(2):283-97
references.pmid: 10919871
references.citation: Trends Neurosci. 1996 Nov;19(11):502-7
references.pmid: 8931277
references.citation: Vis Neurosci. 2006 Nov-Dec;23(6):899-908
references.pmid: 17266782
references.citation: Curr Opin Neurobiol. 2003 Aug;13(4):404-12
references.pmid: 12965286
references.citation: Exp Eye Res. 2010 Dec;91(6):788-92
references.pmid: 20801113
references.citation: Biophys J. 2004 Jun;86(6):3653-62
references.pmid: 15189862
references.citation: Science. 2011 Jun 10;332(6035):1307-12
references.pmid: 21659602
references.citation: Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14044-9
references.pmid: 11707584
references.citation: Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2322-6
references.pmid: 9122193
references.citation: Biochemistry. 1999 Sep 14;38(37):12012-9
references.pmid: 10508404
references.citation: Vision Res. 2003 Dec;43(28):3021-36
references.pmid: 14611938
references.citation: Methods Enzymol. 2000;316:224-52
references.pmid: 10800678
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Oct 12;364(1531):2897-910
references.pmid: 19720652
references.citation: J Physiol. 1979 Mar;288:613-34
references.pmid: 112243
references.citation: J Biol Chem. 2003 Jun 13;278(24):21655-21662
references.pmid: 12663652
references.citation: Vision Res. 1982;22(12):1451-6
references.pmid: 6222537
references.citation: Annu Rev Neurosci. 2001;24:779-805
references.pmid: 11520918
references.citation: Science. 1970 Dec 25;170(3965):1423-6
references.pmid: 4991522
references.citation: Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5804-11
references.pmid: 21642628
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2008 Aug;150(4):369-77
references.pmid: 18514002
references.citation: Methods Mol Biol. 2010;652:95-114
references.pmid: 20552424
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9329-34
references.pmid: 15958532
references.citation: Neuron. 2008 Aug 14;59(3):462-74
references.pmid: 18701071
references.citation: Biophys J. 2002 Jul;83(1):184-93
references.pmid: 12080111
references.citation: Invest Ophthalmol Vis Sci. 1994 Jan;35(1):9-32
references.pmid: 7507907
references.citation: Biochim Biophys Acta. 1975 Oct 9;404(2):300-8
references.pmid: 1182163
references.citation: Science. 1971 Nov 5;174(4009):598-600
references.pmid: 5114823
references.citation: Neuron. 2002 Sep 26;36(1):69-80
references.pmid: 12367507
references.citation: Nat Neurosci. 2009 Mar;12(3):295-302
references.pmid: 19182795
references.citation: Nature. 1967 Dec 23;216(5121):1178-81
references.pmid: 4294735
references.citation: J Gen Physiol. 2007 Jul;130(1):21-40
references.pmid: 17591985
references.citation: Neuron. 2001 Nov 8;32(3):451-61
references.pmid: 11709156
references.citation: J Biol Chem. 2007 Mar 2;282(9):6677-84
references.pmid: 17194706
references.citation: Nat Neurosci. 2008 May;11(5):565-71
references.pmid: 18425122
references.citation: J Neurosci. 2009 Feb 4;29(5):1486-95
references.pmid: 19193895
references.citation: Vis Neurosci. 1994 Mar-Apr;11(2):389-99
references.pmid: 8003460
references.citation: J Physiol. 1994 Oct 15;480 ( Pt 2):261-79
references.pmid: 7532713
references.citation: J Neurosci. 2011 May 25;31(21):7900-9
references.pmid: 21613504
references.citation: Curr Biol. 2009 Oct 13;19(19):1665-9
references.pmid: 19781940
references.citation: Am J Physiol. 1995 Dec;269(6 Pt 2):R1346-50
references.pmid: 8594936
references.citation: J Gen Physiol. 1978 Apr;71(4):369-96
references.pmid: 660156
references.citation: Methods Mol Biol. 2010;652:85-94
references.pmid: 20552423
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19565-70
references.pmid: 18048336
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9855-62
references.pmid: 18632568
references.citation: Neuron. 2001 Mar;29(3):749-55
references.pmid: 11301033
references.citation: Vision Res. 1984;24(11):1551-3
references.pmid: 6533985
references.citation: Proc R Soc Lond B Biol Sci. 1965 Mar 16;162:20-46
references.pmid: 14296430
references.citation: Prog Retin Eye Res. 2004 May;23(3):307-80
references.pmid: 15177205
references.citation: J Neurosci. 2007 Sep 19;27(38):10084-93
references.pmid: 17881515
references.citation: Nature. 2003 Oct 2;425(6957):526-31
references.pmid: 14523449
references.citation: Invest Ophthalmol Vis Sci. 2001 Jan;42(1):3-9
references.pmid: 11133841
references.citation: Nature. 1957 Feb 2;179(4553):255-6
references.pmid: 13407693
references.citation: Nat Neurosci. 2003 Jul;6(7):731-5
references.pmid: 12778053
references.citation: Neuron. 2000 Apr;26(1):181-6
references.pmid: 10798402
references.citation: Vis Neurosci. 2000 Jan-Feb;17(1):97-105
references.pmid: 10750831
references.citation: J Neurosci. 2009 Apr 8;29(14):4616-21
references.pmid: 19357286
references.citation: Prog Retin Eye Res. 2011 Mar;30(2):115-28
references.pmid: 21111842
references.citation: Nature. 1997 Oct 2;389(6650):505-9
references.pmid: 9333241
references.citation: J Neurosci. 2008 Aug 13;28(33):8208-16
references.pmid: 18701683
references.citation: Neuron. 2005 Jun 16;46(6):879-90
references.pmid: 15953417
references.citation: J Neurosci. 2011 Mar 23;31(12):4714-9
references.pmid: 21430170
references.citation: Vision Res. 2004 Dec;44(28):3235-51
references.pmid: 15535992
references.citation: Biochemistry. 2004 May 11;43(18):5532-8
references.pmid: 15122919
references.citation: Biochim Biophys Acta. 2012 Jan;1821(1):137-51
references.pmid: 21447403
references.citation: Prog Retin Eye Res. 2001 Jan;20(1):49-94
references.pmid: 11070368
references.citation: Proc Natl Acad Sci U S A. 1989 Dec;86(23):9606-10
references.pmid: 2594788
references.citation: Methods Mol Biol. 2010;652:129-47
references.pmid: 20552426
references.citation: Neuron. 2002 Sep 26;36(1):81-91
references.pmid: 12367508
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
references.pmid: 10097103
references.citation: Neuron. 1993 Sep;11(3):513-22
references.pmid: 8398144
references.citation: Prog Retin Eye Res. 2010 Nov;29(6):476-86
references.pmid: 20488254
references.citation: J Physiol. 2004 Jan 15;554(Pt 2):417-37
references.pmid: 14594984
references.citation: Prog Retin Eye Res. 2001 Jul;20(4):469-529
references.pmid: 11390257
references.citation: J Biol Chem. 1996 Aug 23;271(34):20621-30
references.pmid: 8702809
references.citation: J Physiol. 1965 Dec;181(3):641-4
references.pmid: 5880382
references.citation: Invest Ophthalmol Vis Sci. 1983 Sep;24(9):1211-26
references.pmid: 6224755
references.citation: Annu Rev Physiol. 2002;64:153-87
references.pmid: 11826267
references.citation: J Physiol. 1997 May 15;501 ( Pt 1):97-109
references.pmid: 9174997
references.citation: J Gen Physiol. 2009 Aug;134(2):137-50
references.pmid: 19635855
references.citation: Invest Ophthalmol Vis Sci. 1987 Jan;28(1):34-49
references.pmid: 3026986
references.citation: Invest Ophthalmol Vis Sci. 2000 Feb;41(2):337-48
references.pmid: 10670460
references.citation: J Gen Physiol. 1995 Sep;106(3):543-57
references.pmid: 8786347
references.citation: J Cell Biol. 2007 Jun 4;177(5):917-25
references.pmid: 17535966
references.citation: J Gen Physiol. 1999 Mar;113(3):491-503
references.pmid: 10051522
references.citation: Physiology (Bethesda). 2010 Apr;25(2):72-84
references.pmid: 20430952
references.citation: J Neurosci. 2008 Nov 5;28(45):11662-72
references.pmid: 18987202