title: Effect of the edible mushroom Mycoleptodonoides aitchisonii on transient global ischemia-induced monoamine metabolism changes in rat cerebral cortex.
abstract: We performed a transient bilateral common carotid artery occlusion on rats and investigated whether feeding an aqueous extract of Mycoleptodonoides aitchisonii, an edible mushroom, affected metabolism of monoamines in the cerebral cortex, possibly protecting against ischemic damage. Seventeen days after the surgery, concentrations of the dopamine (DA) metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and of homovanillic acid (HVA) in the cerebral cortex of the M. aitchisonii-fed group (MV) were higher than in the control ischemia (CV) group. The turnover rate of DA, which was indicated by (DOPAC+HVA)/DA, for the CV group was significantly lower than for the MV group, and the MV group value was the same rate as the sham-operated group. These data indicate that M. aitchisonii affects the dopaminergic neuronal system following brain ischemia damage in the cerebral cortex.
authors.affiliation: COE Program in the 21st Century and Cooperation of Innovative Technology and Advanced Research in Evolutional Area, University of Shizuoka, Shizuoka, Japan. sokuyama@cc.matsuyama-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okuyama
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tashiro
authors.forename: Nien Vinh
authors.initials: NV
authors.lastname: Lam
authors.forename: Tamiko
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Takehiko
authors.initials: T
authors.lastname: Terashima
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000363:Agaricales; D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D020212:Carotid Artery Injuries / Q000150:complications; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D020072:Polyporales; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001688:Biological Products; D004298:Dopamine; D006719:Homovanillic Acid