title: Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus.
abstract: Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not. Bone is an optimal substratum for S. aureus, since this bacterium expresses various adhesins by which can adhere to bone proteins and to the biomaterial surfaces coated with the proteins of the host extracellular matrix. S. aureus is able not only to colonize bone tissues, but also to invade and disrupt them by entering bone cells and inducing cell death and osteolysis. Here we illustrate the pathogenetic mechanisms that can explain how the osteomyelitis sets in and develops around an implant.
authors.affiliation: Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Montanaro
authors.forename: Francesca
authors.initials: F
authors.lastname: Testoni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poggi
authors.forename: Livia
authors.initials: L
authors.lastname: Visai
authors.forename: Pietro
authors.initials: P
authors.lastname: Speziale
authors.forename: Carla Renata
authors.initials: CR
authors.lastname: Arciola
mesh_terms: D000818:Animals; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D010019:Osteomyelitis / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000254:growth & development / Q000472:pathogenicity*