title: Synergistic effect between BRAP polymorphism and diabetes on the extent of coronary atherosclerosis in the Chinese population.
abstract: OBJECTIVE
  Coronary artery disease (CAD) is a multifactorial disease and influenced by genetics. We previously reported that a single nucleotide polymorphism (rs11066001) in the BRAP gene was related to the risk of myocardial infarction. However, it is unclear whether rs11066001 is associated with the extent of coronary atherosclerosis.
  
  
  METHODS
  We enrolled 732 patients scheduled for diagnostic coronary angiography. Angiographic presence of significant CAD (0 or 1), clinical vessel score (CVS, 0-3 vessels) and diffuse score (DS, 0-11.5) were used to evaluate the extent of coronary atherosclerosis. Genotyping was carried out by the TaqMan technology.
  
  
  RESULTS
  Of all patients, 558 (76.2%) had significant CAD. The odds ratio for the GG to the AA genotype was 2.45 (95% CI 1.13-5.34, p = 0.024) for the presence of significant CAD. The CVS was correlated with the frequency of genotypes in the recessive model (p = 0.001). Regression analysis showed a significant association between rs11066001 and the presence of significant CAD and DS (all p < 0.05). There was a synergistic effect between rs11066001 and diabetes on the occurrence of significant CAD (p < 0.001 for interaction).
  
  
  CONCLUSIONS
  The BRAP rs11066001 gene is associated with the extent of coronary atherosclerosis and has a synergistic effect with diabetes on the occurrence of significant CAD in the Chinese population.
authors.affiliation: Division of Cardiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Po-Chao
authors.initials: PC
authors.lastname: Hsu
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lin
authors.forename: Ho-Ming
authors.initials: HM
authors.lastname: Su
authors.forename: Suh-Hang Hank
authors.initials: SH
authors.lastname: Juo
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Sheu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D058065:Diabetic Cardiomyopathies / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000208:ethnology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases