title: Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic  lupus erythematosus in the Malaysian  population.
abstract: Regulated  on activation, normal T-cell expressed and secreted (RANTES) and stromal  cell-derived factor 1 (SDF-1) are members of the CC- and CXC-chemokine  families, respectively. Both genes have been postulated to be involved in the  pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR  of the SDF-1 gene at position 801, in 130 patients presenting SLE at the  Malaya University Medical Centre. Screening of 130 healthy volunteer controls  using RFLP was also performed. RANTES-28 polymorphism analysis showed no  significant (P = 0.3520) relationship, even though homozygous C/C was more  frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent  in healthy controls (OR = 0.7051). There were no significant (P = 0.2650)  associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289)  genotypes in the SDF-1 gene polymorphism with SLE. We conclude that  there is no significant association of RANTES-28 and SDF-1 gene  polymorphisms and occurrence of SLE in Malaysia.
authors.affiliation: Department of Molecular Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: L-H
authors.initials: LH
authors.lastname: Lian
authors.forename: B-P
authors.initials: BP
authors.lastname: Kee
authors.forename: H-L
authors.initials: HL
authors.lastname: Ng
authors.forename: K-H
authors.initials: KH
authors.lastname: Chua
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D018946:Chemokine CCL5 / Q000235:genetics*; D054377:Chemokine CXCL12 / Q000235:genetics*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D008296:Malaysia / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; C483024:CCL5 protein, human; C515255:CXCL12 protein, human; D018946:Chemokine CCL5; D054377:Chemokine CXCL12