title: The effect of omega-3 on the serum visfatin concentration in patients with type II diabetes.
abstract: BACKGROUND
  Visfatin is an adipocytokine which is secreted from adipose tissue and can affect on the diabetes inflammatory reaction and also serum lipids level. On the other hand, Omega-3 can also prevent formation of insulin resistance. In the present study, the effect of Omega-3 on the serum visfatin concentration was evaluated.
  
  
  METHODS
  71 women with type II diabetes were randomly assigned to the group that took Omega-3 capsules or control group with placebo capsules. In the first step, study subjects filled a questionnaire collecting their age, height, weight, waist circumference, and hip circumference. Also their blood samples were taken for blood tests. In the second step, the intervention was done for 8 weeks and in the third step the aforementioned were collected again. In the blood samples visfatin and lipid profiles (low density lipoprotein [LDL], high density lipoprotein [HDL], triglyceride [TG], and cholesterol), glucose and HbA1c were measured.
  
  
  RESULTS
  There was no significant difference in serum visfatin level between Omega-3 and placebo groups before the intervention (p = 0.14), while after the intervention, the mean serum visfatin level in the Omega-3 group was significantly higher (p < 0.001). In addition, the mean difference between the serum visfatin level before and after the intervention in both groups was significant (p < 0.001).
  
  
  CONCLUSIONS
  This study showed an increase in visfatin level following consuming Omega-3 fats but according to controversial issues on insulin-like function of visfatin, the effects of Omega-3 on diabetes should be studied more in further studies.
authors.affiliation: Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hajianfar
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Hosseinzadeh
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bahonar
authors.forename: Kazem
authors.initials: K
authors.lastname: Mohammad
authors.forename: Golam Reza
authors.initials: GR
authors.lastname: Askari
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Entezari
authors.forename: Ali
authors.initials: A
authors.lastname: Keshavarz
authors.forename: Nazli
authors.initials: N
authors.lastname: Ansari
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