title: Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. in alloxan induced diabetic albino mice.
abstract: OBJECTIVE
  To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth. bark in alloxan induced diabetic mice.
  
  
  METHODS
  Group-I (normal control) mice received only basal diet without any treatment. In Group- II (Diabetic control) mice, diabetes was induced by alloxan (150 mg/kg i.p.) and received only Tween 80, 5% v/v in normal saline. Group- III and Group- IV mice received metformin (10mg/kg) and gliclazide (10 mg/kg) as standard drugs. Group- V and VI mice received methanolic bark extract of Albizia odoratissimaat doses of 250 and 500 mg/kg body weight p.o., respectively.
  
  
  RESULTS
  The results of the study indicates that Albizia odoratissima bark extract significantly (P<0.01) reduced the blood sugar level. The bark extract also significantly reduced the levels of serum cholesterol, triglycerides, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.
  
  
  CONCLUSIONS
  Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues (pancreas, kidney, liver, heart and spleen), thereby reducing the causation of diabetes in experimental animals.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India. dineshbarbola@yahoo.co.in
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kumar
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.forename: Sonia
authors.initials: S
authors.lastname: Kohli
authors.forename: Renu
authors.initials: R
authors.lastname: Arya
authors.forename: Jyoti
authors.initials: J
authors.lastname: Gupta
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D031289:Albizzia / Q000737:chemistry*; D000469:Alkaline Phosphatase / Q000097:blood; D000496:Alloxan; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D010936:Plant Extracts; D014280:Triglycerides; D000496:Alloxan; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase