title: A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.
abstract: OBJECTIVE
  Deep brain stimulation (DBS) has been recently investigated as a treatment for major depression. One of the proposed targets for this application is the subcallosal cingulate gyrus (SCG). To date, promising results after SCG DBS have been reported by a single center. In the present study the authors investigated whether these findings may be replicated at different institutions. They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression.
  
  
  METHODS
  Twenty-one patients underwent implantation of bilateral SCG electrodes. The authors examined the reduction in Hamilton Rating Scale for Depression (HRSD-17) score from baseline (RESP50).
  
  
  RESULTS
  Patients treated with SCG DBS had an RESP50 of 57% at 1 month, 48% at 6 months, and 29% at 12 months. The response rate after 12 months of DBS, however, increased to 62% when defined as a reduction in the baseline HRSD-17 of 40% or more. Reductions in depressive symptomatology were associated with amelioration in disease severity in patients who responded to surgery.
  
  
  CONCLUSIONS
  Overall, findings from this study corroborate the results of previous reports showing that outcome of SCG DBS may be replicated across centers.
authors.affiliation: Division of Neurosurgery, University of Toronto, Canada. lozano@uhnresearch.ca
authors.forename: Andres M
authors.initials: AM
authors.lastname: Lozano
authors.forename: Peter
authors.initials: P
authors.lastname: Giacobbe
authors.forename: Clement
authors.initials: C
authors.lastname: Hamani
authors.forename: Sakina J
authors.initials: SJ
authors.lastname: Rizvi
authors.forename: Sidney H
authors.initials: SH
authors.lastname: Kennedy
authors.forename: Theodore T
authors.initials: TT
authors.lastname: Kolivakis
authors.forename: Guy
authors.initials: G
authors.lastname: Debonnel
authors.forename: Abbas F
authors.initials: AF
authors.lastname: Sadikot
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Lam
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Howard
authors.forename: Magda
authors.initials: M
authors.lastname: Ilcewicz-Klimek
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Honey
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D003337:Corpus Callosum; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D004351:Drug Resistance; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents