title: Old friends form alliance against podocytes.
abstract: Wang and colleagues identify the activation of Wnt signaling as an important downstream event in transforming growth factor-β-mediated podocyte injury. Supported by other recent studies, canonical Wnt signaling is emerging as a critical stress pathway in podocytes and may be exploited for therapeutic strategies in the treatment of glomerulopathies.
authors.affiliation: Center for Systems Biology, ZBSA, Albert Ludwig University of Freiburg, Freiburg, Germany. matias.simons@uniklinik-freiburg.de
authors.forename: Matias
authors.initials: M
authors.lastname: Simons
authors.forename: Tobias B
authors.initials: TB
authors.lastname: Huber
mesh_terms: D000818:Animals; D050199:Podocytes / Q000473:pathology*; D011507:Proteinuria / Q000209:etiology*; D053773:Transforming Growth Factor beta1 / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C495267:CTNNB1 protein, mouse; D053773:Transforming Growth Factor beta1; D051153:Wnt Proteins; D051176:beta Catenin