title: [Evaluation of measurement method of a bacterial sepsis marker, procalcitonin].
abstract: Procalcitonin (PCT) is a novel biomarker for diagnosis and severity evaluation of bacterial sepsis. PCT measurement methods provided by Wako Pure Chemical Industries, Ltd. include a fully automated chemiluminescent immunoassay system SphereLight Wako and fully automated immunoanalyzer microTASWako i30 for a quantitative measurement, and immunochromatographic assay method, B R A H M S PCT-Q kit. This time, basic performance of SphereLight Wako and microTASWako i30 was evaluated as quantitative determination methods for PCT. The lower limit of detection for the both methods was 0.02 ng/ml. Correlation coefficients of 0.993 to 0.997 indicated good correlation between the two methods. The both methods allow quick and easy measurement of PCT, therefore they are helpful for diagnosis and severity evaluation of bacterial sepsis.
authors.affiliation: Wako Pure Chemical Industries., Ltd., 1-2 Doshomachi 3-chome, Chuo-ku, Osaka 541-0045, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Adachi
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakao
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation; D008163:Luminescent Measurements / Q000295:instrumentation; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide