title: Role of T cell-nuclear factor κB in transplantation.
abstract: Nuclear factor (NF) κB is a pleiotropic transcription factor that is ubiquitously expressed. After transplantation of solid organs, NF-κB in the graft is activated within a few hours as a consequence of ischemia/reperfusion and then again after a few days in intragraft infiltrating cells during the process of acute allograft rejection. In the present article, we review the components of the NF-κB pathway, their mechanisms of activation, and their role in T cell and antigen-presenting cell activation and differentiation and in solid organ allograft rejection. Targeted inhibition of NF-κB in selected cell types may promote graft survival with fewer adverse effects compared with global immunosuppressive therapies.
authors.affiliation: Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USA. lmoliner@medicine.bsd.uchicago.edu
authors.forename: Luciana L
authors.initials: LL
authors.lastname: Molinero
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Alegre
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000502:physiology; D015427:Reperfusion Injury / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology
chemical_list: D016328:NF-kappa B
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