title: Metal complexes of diisopropylthiourea: synthesis, characterization and antibacterial studies.
abstract: Co(II), Cu(II), Zn(II) and Fe(III) complexes of diisopropylthiourea have been synthesized and characterized by elemental analyses, molar conductivity, magnetic susceptibility, FTIR and electronic spectroscopy. The compounds are non-electrolytes in solution and spectroscopic data of the complexes are consistent with 4-coordinate geometry for the metal(II) complexes and six coordinate octahedral for Fe(III) complex. The complexes were screened for their antibacterial activities against six bacteria: Escherichia coli, Pseudomonas auriginosa, Klebsiella pneumoniae, Bacillus cereus, Staphylococcus aureus and Bacillus pumilus. The complexes showed varied antibacterial activities and their minimum inhibitory concentrations (MICs) were determined.
authors.affiliation: Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa; E-Mail:  nzulu@ufh.ac.za.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Ajibade
authors.forename: Nonkululeko H
authors.initials: NH
authors.lastname: Zulu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D017550:Spectroscopy, Fourier Transform Infrared; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D008670:Metals; D013890:Thiourea
references.citation: J Med Chem. 2004 Oct 7;47(21):5204-9
references.pmid: 15456263
references.citation: Semin Hematol. 2004 Apr;41(2):173-88
references.pmid: 15071793
references.citation: J Inorg Biochem. 2003 Jul 1;95(4):249-58
references.pmid: 12818795
references.citation: Parasitol Res. 2001 Mar;87(3):239-44
references.pmid: 11293573
references.citation: J Inorg Biochem. 2002 Apr 10;89(1-2):74-82
references.pmid: 11931966
references.citation: Bioorg Med Chem Lett. 2001 Jul 9;11(13):1703-7
references.pmid: 11425542
references.citation: Eur J Med Chem. 2009 Feb;44(2):736-44
references.pmid: 18571774
references.citation: Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):85-96
references.pmid: 11425181
references.citation: J Med Chem. 1996 Sep 27;39(20):3853-74
references.pmid: 8831751
references.citation: Biochem Pharmacol. 2006 Mar 30;71(7):1036-41
references.pmid: 16288993
references.citation: Bioinorg Chem Appl. 2009;:413175
references.pmid: 19865487