title: Epidermal growth factor receptors: a functional perspective.
abstract: The epidermal growth factor receptors (EGFRs) belong to the ErbB family of receptor tyrosine kinases (TKs) involved in the proliferation of normal and malignant cells. EGFR has attracted considerable attention as a target for cancer therapy. This article considers various functional roles of EGFR-based systems that are relevant for the early detection and staging of cancers overexpressing EGFR.
authors.affiliation: Indian Institute of Technology Roorkee, India. petar.mitrasinovic@yahoo.com
authors.forename: Petar M
authors.initials: PM
authors.lastname: Mitrasinovic
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D055088:Early Detection of Cancer / Q000379:methods; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D049268:Positron-Emission Tomography / Q000379:methods; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D016719:Radioimmunodetection / Q000379:methods; D019275:Radiopharmaceuticals
chemical_list: D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors; D019275:Radiopharmaceuticals; D066246:ErbB Receptors