title: [The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress].
abstract: OBJECTIVE
  To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia.
  
  
  METHODS
  Experiments were performed on Wistar rats divided into following groups: Group I (control) received saline; Group II (LA) received lipoic acid (60 mg/kg b.w.); Group III (LPS) received lipopolysaccharide (30 mg/kg b.w.); Group IV (LPS+LA) received LPS (30 mg/kg b.w.) and 30 min later LA (60 mg/kg b.w.). Five hours after last injection rats were sacrificed, and the liver and spleen were harvested for subsequent total protein assay.
  
  
  RESULTS
  Lipoic acid administration led to a significant increase in total protein concentration in the liver and spleen tissue of endotoxemic rats when compared to control.
  
  
  CONCLUSIONS
  Lipoic acid administration during early phase of LPS-induced oxidative stress increase protein level in the liver and spleen tissue, which indicate an increase of antioxidant properties of an organism.
authors.affiliation: Uniwersytet Medyczny w Łodzi, Katedra Fizjologii Doświadczalnej i Klinicznej, Zakład Fizjologii Układu Krazenia.
authors.forename: Halina
authors.initials: H
authors.lastname: Huk-Kolega
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piechota
authors.forename: Paulina
authors.initials: P
authors.lastname: Kleniewska
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Michalski
authors.forename: Anna
authors.initials: A
authors.lastname: Goraca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism*; D008063:Thioctic Acid / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008070:Lipopolysaccharides; D011506:Proteins; D008063:Thioctic Acid