title: [Current treatment options in acute myeloid leukemia].
abstract: Genetic aberrations form the basis for diagnostic classification of patients with acute myeloid leukemia (AML) according to the World Health Organization (WHO) classification. Moreover, these aberrations predict response to induction chemotherapy, relapse-free survival, and overall survival of patients with AML. Understanding the pathogenetic role of cytogenetic and molecular changes has led to the development of targeted treatment strategies that require rapid diagnostic assessment of the genetic profile of each patient to select the best treatment available.
authors.affiliation: Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, Hannover, Germany. heuser.michael@mh-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Heuser
authors.forename: R F
authors.initials: RF
authors.lastname: Schlenk
authors.forename: A
authors.initials: A
authors.lastname: Ganser
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000639:trends*
chemical_list: D000970:Antineoplastic Agents
references.citation: Lancet Oncol. 2009 Mar;10(3):223-32
references.pmid: 19230772
references.citation: Blood. 2011 Feb 24;117(8):2469-75
references.pmid: 21177436
references.citation: Blood. 2011 Oct 6;118(14):3832-41
references.pmid: 21828126
references.citation: J Clin Oncol. 2011 Feb 10;29(5):487-94
references.pmid: 21220605
references.citation: J Clin Oncol. 2010 Feb 1;28(4):562-9
references.pmid: 20026804
references.citation: N Engl J Med. 2008 May 1;358(18):1909-18
references.pmid: 18450602
references.citation: Br J Haematol. 2007 Feb;136(4):624-7
references.pmid: 17223919
references.citation: N Engl J Med. 2009 Sep 24;361(13):1249-59
references.pmid: 19776406
references.citation: J Clin Oncol. 2010 Aug 1;28(22):3636-43
references.pmid: 20567020
references.citation: Cancer. 2007 Mar 15;109(6):1114-24
references.pmid: 17315155
references.citation: J Clin Oncol. 1989 Sep;7(9):1268-74
references.pmid: 2475589
references.citation: J Clin Oncol. 2010 May 10;28(14):2356-64
references.pmid: 20368538
references.citation: N Engl J Med. 2009 Sep 24;361(13):1235-48
references.pmid: 19776405
references.citation: J Clin Oncol. 2010 Feb 1;28(4):596-604
references.pmid: 20026798
references.citation: Br J Haematol. 2009 Jun;145(5):598-605
references.pmid: 19344426
references.citation: J Clin Oncol. 2009 Jan 1;27(1):61-9
references.pmid: 19047294
references.citation: Blood. 2010 Aug 12;116(6):971-8
references.pmid: 20442365
references.citation: J Clin Oncol. 2011 Jul 20;29(21):2889-96
references.pmid: 21670448
references.citation: J Clin Oncol. 2011 Feb 1;29(4):369-77
references.pmid: 21172891
references.citation: JAMA. 2009 Jun 10;301(22):2349-61
references.pmid: 19509382
references.citation: Blood. 2009 Apr 30;113(18):4179-87
references.pmid: 19008455
references.citation: Blood. 2010 Nov 25;116(22):4422-9
references.pmid: 20668231
references.citation: J Clin Oncol. 2011 Feb 20;29(6):682-9
references.pmid: 21205756
references.citation: J Clin Oncol. 2010 Oct 20;28(30):4642-8
references.pmid: 20805454
references.citation: Blood. 2010 Jul 29;116(4):614-6
references.pmid: 20421455
references.citation: N Engl J Med. 1994 Oct 6;331(14):896-903
references.pmid: 8078551
references.citation: Haematologica. 2009 Jan;94(1):54-60
references.pmid: 19059939
references.citation: J Clin Oncol. 2010 Feb 10;28(5):808-14
references.pmid: 20048183
references.citation: J Clin Oncol. 2010 May 10;28(14):2389-95
references.pmid: 20385984
references.citation: Blood. 2009 Oct 1;114(14):2857-8
references.pmid: 19797531
references.citation: Lancet. 2010 Dec 11;376(9757):2000-8
references.pmid: 21131036
references.citation: N Engl J Med. 2009 May 28;360(22):2289-301
references.pmid: 19474426
references.citation: Arch Intern Med. 2002 Jul 22;162(14):1597-603
references.pmid: 12123403