title: The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis.
abstract: The National Blood Foundation (NBF) support was critical in the author's research career development. The NBF support came in the form of a start-up seed grant that she got from the American Association of Blood Banks, an organization that advances the practice and standards of transfusion medicine and cellular therapies and an organization in which she is a proud member. The NBF grant enabled her to keep up with her transfusion medicine practice while pursuing her passion to be a physician scientist. During its funding period, she was able to obtain critical preliminary bench data and to secure several National Institutes of Health grants with over a million dollars direct cost. In addition, the knowledge gained from the NBF-supported projects is currently being translated into medical practice in her lab by testing on cord blood expansion. She is looking forward to spending the upcoming years of her professional career bridging bedside observations on transfusion medicine with bench experiences and then utilizing that bench-derived knowledge in the practice of transfusion medicine.
authors.affiliation: Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. lchai@partners.org
authors.forename: Li
authors.initials: L
authors.lastname: Chai
mesh_terms: D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D016158:Genes, p53; D006410:Hematopoiesis / Q000235:genetics* / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D010051:Ovarian Neoplasms / Q000235:genetics; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics* / Q000502:physiology; D016335:Zinc Fingers / Q000235:genetics* / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D047908:Intracellular Signaling Peptides and Proteins; C104146:SALL1 protein, human; C104147:SALL2 protein, human; C484466:SALL3 protein, human; C472575:SALL4 protein, human; C491254:Sall1 protein, mouse; C403266:Sall2 protein, mouse; C484467:Sall3 protein, mouse; C509167:Sall4 protein, mouse; D014157:Transcription Factors
references.citation: Clin Dysmorphol. 1998 Oct;7(4):295-8
references.pmid: 9823498
references.citation: Am J Med Genet A. 2007 Feb 15;143(4):326-32
references.pmid: 17256792
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16319-24
references.pmid: 17060609
references.citation: Development. 2006 Aug;133(15):3005-13
references.pmid: 16790473
references.citation: Development. 1997 Aug;124(16):3147-56
references.pmid: 9272955
references.citation: PLoS One. 2009;4(5):e5577
references.pmid: 19440552
references.citation: Ann N Y Acad Sci. 1999 Apr 30;872:289-303; discussion 303-4
references.pmid: 10372131
references.citation: Clin Genet. 1988 Sep;34(3):195-200
references.pmid: 3180506
references.citation: Blood. 2006 Oct 15;108(8):2726-35
references.pmid: 16763212
references.citation: Mech Dev. 1996 May;56(1-2):117-28
references.pmid: 8798152
references.citation: Nat Cell Biol. 2006 Oct;8(10):1114-23
references.pmid: 16980957
references.citation: J Med Genet. 2003 Jul;40(7):473-8
references.pmid: 12843316
references.citation: Cell. 1997 Feb 7;88(3):287-98
references.pmid: 9039255
references.citation: EMBO J. 1994 Jan 1;13(1):168-79
references.pmid: 7905822
references.citation: PLoS One. 2010 May 21;5(5):e10766
references.pmid: 20505821
references.citation: Hum Mol Genet. 2002 Nov 1;11(23):2979-87
references.pmid: 12393809
references.citation: Genomics. 1996 Dec 15;38(3):291-8
references.pmid: 8975705
references.citation: Biochem Biophys Res Commun. 1999 Oct 14;264(1):151-6
references.pmid: 10527856
references.citation: EMBO J. 1988 Jan;7(1):189-96
references.pmid: 16453820
references.citation: Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14619-24
references.pmid: 11734654
references.citation: Mol Cell Biol. 2003 Jan;23(1):62-9
references.pmid: 12482961
references.citation: Blood. 2008 Aug 1;112(3):805-13
references.pmid: 18487508
references.citation: J Biol Chem. 2001 Dec 21;276(51):48223-30
references.pmid: 11577094
references.citation: Genomics. 1999 Dec 1;62(2):216-22
references.pmid: 10610715
references.citation: Am J Hum Genet. 2002 Nov;71(5):1195-9
references.pmid: 12395297
references.citation: Genesis. 2007 Jan;45(1):51-8
references.pmid: 17216607
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10838-43
references.pmid: 8855267
references.citation: Leukemia. 2000 Jun;14(6):973-90
references.pmid: 10865962
references.citation: Mol Cell Biol. 2004 May;24(9):3885-93
references.pmid: 15082782
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10494-9
references.pmid: 17557835
references.citation: Mech Dev. 1996 Mar;55(1):19-32
references.pmid: 8734496
references.citation: J Med Genet. 2004 Aug;41(8):e102
references.pmid: 15286162
references.citation: Am J Hum Genet. 1999 Feb;64(2):435-45
references.pmid: 9973281
references.citation: Cancer Res. 1997 Feb 1;57(3):513-5
references.pmid: 9012483
references.citation: Mol Cell Biol. 1996 Sep;16(9):4717-25
references.pmid: 8756629
references.citation: Int J Hematol. 2002 Jun;75(5):466-72
references.pmid: 12095145
references.citation: Genes Dev. 1996 Aug 1;10(15):1953-65
references.pmid: 8756352