title: Ruthenium-catalyzed C-H/N-O bond functionalization: green isoquinolone syntheses in water.
abstract: Ruthenium-catalyzed isoquinolone syntheses with ample scope were accomplished through carboxylate assistance in environmentally benign water as a reaction medium. The high chemoselectivity of the ruthenium(II) carboxylate complex also set the stage for the direct use of free hydroxamic acids for annulations of alkynes.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
authors.forename: Sabine
authors.initials: S
authors.lastname: Fenner
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D003124:Colorimetry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D001549:Benzamides; D002264:Carboxylic Acids; D007546:Isoquinolines; D014867:Water; D012428:Ruthenium