title: Intracytoplasmic sperm injection in partial globozoospermia.
abstract: OBJECTIVE
  To compare the outcome of intracytoplasmic sperm injection (ICSI) in patient couples where the male partner has partial globozoospermia with the outcome in a general ICSI population.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Center for Reproductive Medicine, Radboud University Nijmegen Medical Center, the Netherlands, a tertiary referral center.
  
  
  METHODS
  Between 1997 and 2005, 42 couples were identified in which the male presented with partial globozoospermia; 27 couples treated with ICSI were matched with 263 control couples from a general ICSI population regarding female age and year of first ICSI cycle.
  
  
  METHODS
  One ICSI treatment (1-10 ICSI cycles).
  
  
  METHODS
  Live birth rate after one ICSI treatment (1-10 ICSI cycles).
  
  
  RESULTS
  In the partial globozoospermia group, the live birth rate was 66.7% compared with 50.0% in the control group. In partial globozoospermia, three out of 21 pregnancies ended in a miscarriage, one major birth defect occurred, and one pregnancy ended in a neonatal death due to sepsis in a premature child, compared with four stillborn in the control group.
  
  
  CONCLUSIONS
  ICSI is an effective treatment in couples that failed to conceive spontaneously within 1 year combined with male infertility due to partial globozoospermia. The fertilization rates and the live birth rates in this specific group did not differ from those of the general ICSI population.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.dam@obgyn.umcn.nl
authors.forename: Anika H D M
authors.initials: AH
authors.lastname: Dam
authors.forename: Adriënne J E
authors.initials: AJ
authors.lastname: Pijnenburg
authors.forename: Jan C M
authors.initials: JC
authors.lastname: Hendriks
authors.forename: Hans
authors.initials: H
authors.lastname: Westphal
authors.forename: Liliana
authors.initials: L
authors.lastname: Ramos
authors.forename: Jan A M
authors.initials: JA
authors.lastname: Kremer
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000473:pathology / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012720:Severity of Illness Index; D056826:Single Embryo Transfer / Q000379:methods; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013094:Spermatozoa / Q000473:pathology; D050497:Stillbirth; D055815:Young Adult