title: Antitumor peptides from marine organisms.
abstract: The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Lan-Hong
authors.initials: LH
authors.lastname: Zheng
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Yue-Jun
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Pharmacology, Capital Medical University, Beijing 100069, China.|Institute of Oceanology, Chinese Academy of Science, Qingdao 266071, China.
authors.forename: Xiu-Kun
authors.initials: XK
authors.lastname: Lin
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Sun
mesh_terms: D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms / Q000737:chemistry*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008870:Microtubules / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D014404:Tubulin / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D010455:Peptides; D014404:Tubulin
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