title: Analysing the composition of outpatient antibiotic use: a tutorial on compositional data analysis.
abstract: In this tutorial, statistical methods for studying outpatient use of antibiotics in Europe are described, using data provided by IMS Health. The methods are applied to two related research questions, namely the assessment of changes in the relative volume of use of different antibiotic subclasses over time and changes in the absolute volume of antibiotic use.
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, University of Hasselt, Hasselt, Belgium. christel.faes@uhasselt.be
authors.forename: Christel
authors.initials: C
authors.lastname: Faes
authors.forename: Geert
authors.initials: G
authors.lastname: Molenberghs
authors.forename: Niel
authors.initials: N
authors.lastname: Hens
authors.forename: Arno
authors.initials: A
authors.lastname: Muller
authors.forename: Herman
authors.initials: H
authors.lastname: Goossens
authors.forename: Samuel
authors.initials: S
authors.lastname: Coenen
mesh_terms: D000553:Ambulatory Care / Q000706:statistics & numerical data; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D019295:Computational Biology / Q000379:methods; D003627:Data Interpretation, Statistical; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data* / Q000639:trends; D005843:Geography; D006801:Humans; D010045:Outpatients / Q000706:statistics & numerical data*; D010406:Penicillins / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D013752:Tetracycline