title: Honatisine, a novel diterpenoid alkaloid, and six known alkaloids from Delphinium honanense and their cytotoxic activity.
abstract: A novel diterpene alkaloid named honatisine (1) has been isolated from the whole plants of Delphinium honanense, along with six known alkaloids, siwanine E (2), isoatisine (3), atisine (4), delcorinine (5), uraphine (6), and nordhagenine A (7). Their structures were deduced on the basis of their spectral data. All of them were evaluated by a SRB assay for their cytotoxicity, and compound 1 showed a significant cytotoxic activity (IC(50) =3.16 μM) against the MCF-7 cell line.
authors.affiliation: Department of Applied Chemistry, Xi'an University of Technology, Xi'an, P R China. hyq7978863@163.com
authors.forename: Yang Qing
authors.initials: YQ
authors.lastname: He
authors.forename: Zhan Ying
authors.initials: ZY
authors.lastname: Ma
authors.forename: Xiao Mei
authors.initials: XM
authors.lastname: Wei
authors.forename: Dong Jie
authors.initials: DJ
authors.lastname: Liu
authors.forename: Bao Zhong
authors.initials: BZ
authors.lastname: Du
authors.forename: Bing Hua
authors.initials: BH
authors.lastname: Yao
authors.forename: Li Ming
authors.initials: LM
authors.lastname: Gao
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D031882:Delphinium / Q000737:chemistry* / Q000254:growth & development; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C572116:honatisine