title: Gold nanoparticle induces masking of amines and some therapeutic implications.
abstract: Citrate capped gold nanoparticles (GNP) are effective in masking protein amines. The extent of such masking is quantified using Fourier Transform Infra Red (FTIR) spectroscopy. A strong correlation is shown to exist between a shift of amide-II peak intensity (1600-1500 cm(-1)) caused by GNP and the number of exposed amines in a given protein. The result is validated using eight different proteins. The expected out-come of such masking is inhibition of interaction between any external ligand and such amines. The prediction is validated using a simple non-enzymatic glycation of clinically important protein like crystallin.
authors.affiliation: Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, India.
authors.forename: Santiswarup
authors.initials: S
authors.lastname: Singha
authors.forename: Anjan K
authors.initials: AK
authors.lastname: Dasgupta
authors.forename: Himadri
authors.initials: H
authors.lastname: Datta
mesh_terms: D000588:Amines / Q000737:chemistry*; D017127:Glycation End Products, Advanced; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D038201:alpha-Crystallins / Q000737:chemistry
chemical_list: D000588:Amines; D017127:Glycation End Products, Advanced; D038201:alpha-Crystallins; D006046:Gold