title: Neuronal basis for object location in the vibrissa scanning sensorimotor system.
abstract: An essential issue in perception is how the location of an object is estimated from tactile signals in the context of self-generated changes in sensor configuration. Here, we review the pathways and dynamics of neuronal signals that encode touch in the rodent vibrissa sensorimotor system. Rodents rhythmically scan an array of long, facial hairs across a region of interest. Behavioral evidence shows that these animals maintain knowledge of the azimuthal position of their vibrissae. Electrophysiological measurements have identified a reafferent signal of the azimuth that is coded in normalized coordinates, broadcast throughout primary sensory cortex and provides strong modulation of signals of vibrissa contact. Efferent signals in motor cortex report the range of the scan. Collectively, these signals allow the rodent to form a percept of object location.
authors.affiliation: Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA. dk@physics.ucsd.edu
authors.forename: David
authors.initials: D
authors.lastname: Kleinfeld
authors.forename: Martin
authors.initials: M
authors.lastname: Deschênes
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D006801:Humans; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics; D010507:Periodicity; D010812:Physical Stimulation; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation / Q000502:physiology*
references.citation: Neuron. 2007 Jan 4;53(1):117-33
references.pmid: 17196535
references.citation: J Comp Neurol. 1993 Feb 8;328(2):232-51
references.pmid: 8423242
references.citation: Neuron. 2002 Jun 13;34(6):1021-34
references.pmid: 12086648
references.citation: Front Neuroanat. 2008 Sep 12;2:4
references.pmid: 18958201
references.citation: Exp Neurol. 1988 Feb;99(2):369-87
references.pmid: 3338529
references.citation: Somatosens Mot Res. 2003;20(2):163-9
references.pmid: 12850826
references.citation: Nature. 2009 Oct 15;461(7266):923-9
references.pmid: 19829372
references.citation: Neuron. 2007 Oct 4;56(1):43-57
references.pmid: 17920014
references.citation: PLoS Biol. 2007 Feb;5(2):e15
references.pmid: 17227143
references.citation: J Neurosci. 2000 Oct 1;20(19):7455-62
references.pmid: 11007905
references.citation: Acta Neurobiol Exp (Wars). 2004;64(2):229-38
references.pmid: 15366255
references.citation: J Neurosci. 2007 Dec 26;27(52):14231-8
references.pmid: 18160630
references.citation: Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1717-27
references.pmid: 12626006
references.citation: J Physiol. 2010 Oct 1;588(Pt 19):3757-83
references.pmid: 20724365
references.citation: Neuron. 2010 Feb 11;65(3):422-35
references.pmid: 20159454
references.citation: J Neurophysiol. 1986 Oct;56(4):1196-223
references.pmid: 3783236
references.citation: J Physiol. 2011 Jan 15;589(Pt 2):263-81
references.pmid: 21059765
references.citation: Exp Brain Res. 1994;99(2):223-32
references.pmid: 7523173
references.citation: Curr Opin Neurobiol. 2002 Aug;12(4):441-7
references.pmid: 12139993
references.citation: J Neurophysiol. 2003 Jan;89(1):104-17
references.pmid: 12522163
references.citation: Nature. 2004 Feb 19;427(6976):704-10
references.pmid: 14973477
references.citation: PLoS Biol. 2006 May;4(5):e124
references.pmid: 16605304
references.citation: Ann N Y Acad Sci. 2011 Apr;1225:110-8
references.pmid: 21534998
references.citation: J Comput Neurosci. 2009 Oct;27(2):277-90
references.pmid: 19353260
references.citation: Somatosens Mot Res. 2001;18(3):211-22
references.pmid: 11562084
references.citation: Somatosens Mot Res. 1995;12(1):1-9
references.pmid: 7571939
references.citation: J Neurophysiol. 2010 Sep;104(3):1661-72
references.pmid: 20610783
references.citation: J Neurosci. 2007 Dec 26;27(52):14404-14
references.pmid: 18160648
references.citation: Neuron. 2005 Feb 3;45(3):447-57
references.pmid: 15694330
references.citation: Nat Neurosci. 2011 Jul 10;14(8):1089-93
references.pmid: 21743473
references.citation: J Neurosci. 2007 Nov 7;27(45):12407-12
references.pmid: 17989305
references.citation: Brain Res. 1969 Jan;12(1):138-56
references.pmid: 5802473
references.citation: J Neurosci. 2006 Aug 16;26(33):8451-64
references.pmid: 16914670
references.citation: Prog Brain Res. 2005;149:31-40
references.pmid: 16226574
references.citation: J Neurophysiol. 2006 Jul;96(1):27-39
references.pmid: 16641375
references.citation: J Neurosci. 2001 Jul 15;21(14):5251-61
references.pmid: 11438600
references.citation: J Physiol. 2006 Feb 15;571(Pt 1):101-20
references.pmid: 16357010
references.citation: J Gen Physiol. 2011 Sep;138(3):291-301
references.pmid: 21875978
references.citation: J Comp Neurol. 1981 Sep 10;201(2):221-42
references.pmid: 7287928
references.citation: J Neurophysiol. 1980 Apr;43(4):1156-67
references.pmid: 6766997
references.citation: Cells Tissues Organs. 2011;193(3):207-14
references.pmid: 21311188
references.citation: J Comp Neurol. 2010 Nov 15;518(22):4546-66
references.pmid: 20886621
references.citation: J Neurophysiol. 2008 Aug;100(2):681-9
references.pmid: 18234976
references.citation: Curr Opin Neurobiol. 2007 Aug;17(4):408-16
references.pmid: 17702566
references.citation: J Comp Neurol. 1993 Nov 15;337(3):386-99
references.pmid: 8282849
references.citation: Cereb Cortex. 2008 May;18(5):979-89
references.pmid: 17702950
references.citation: J Comp Neurol. 2004 Nov 22;479(4):360-73
references.pmid: 15514982
references.citation: Neuron. 2007 Nov 21;56(4):714-25
references.pmid: 18031687
references.citation: Somatosens Mot Res. 1999;16(2):69-88
references.pmid: 10449057
references.citation: Proc Biol Sci. 2007 Apr 22;274(1613):1035-41
references.pmid: 17331893
references.citation: J Neurophysiol. 1989 Feb;61(2):311-30
references.pmid: 2918357
references.citation: Psychol Bull. 1977 May;84(3):477-88
references.pmid: 859958
references.citation: J Comp Neurol. 1996 Nov 18;375(3):481-501
references.pmid: 8915844
references.citation: J Comp Neurol. 2003 Nov 24;466(4):525-44
references.pmid: 14566947
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16446-50
references.pmid: 19805318
references.citation: Nature. 2001 Aug 23;412(6849):787-92
references.pmid: 11518957
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12348-53
references.pmid: 15297618
references.citation: J Comp Neurol. 1985 Feb 1;232(1):55-69
references.pmid: 3973083
references.citation: Somatosens Mot Res. 1995;12(3-4):249-75
references.pmid: 8834301
references.citation: PLoS Biol. 2006 Nov;4(12):e382
references.pmid: 17121453
references.citation: Neurosci Res. 2009 Jul;64(3):323-9
references.pmid: 19376165
references.citation: Nat Rev Neurosci. 2008 Aug;9(8):601-12
references.pmid: 18641667
references.citation: J Comp Neurol. 1979 Nov 1;188(1):75-86
references.pmid: 500855
references.citation: J Neurosci. 2011 Jun 15;31(24):8699-705
references.pmid: 21677152
references.citation: J Neurosci. 2010 Mar 24;30(12):4256-60
references.pmid: 20335461
references.citation: Cereb Cortex. 2010 Oct;20(10):2287-303
references.pmid: 20534783
references.citation: J Neurophysiol. 2012 Jan;107(2):551-63
references.pmid: 21994257
references.citation: J Neurosci. 2005 Sep 7;25(36):8250-8
references.pmid: 16148232
references.citation: J Neurophysiol. 1978 May;41(3):798-820
references.pmid: 660231
references.citation: J Neurosci. 2008 Mar 26;28(13):3438-55
references.pmid: 18367610
references.citation: J Neurosci. 2006 Aug 23;26(34):8838-46
references.pmid: 16928873
references.citation: Brain Struct Funct. 2007 Jul;212(1):3-17
references.pmid: 17717695
references.citation: J Neurophysiol. 2010 Nov;104(5):2532-42
references.pmid: 20844105
references.citation: J Neurosci. 2008 Feb 20;28(8):1789-97
references.pmid: 18287495
references.citation: Exp Brain Res. 2010 Jan;200(3-4):197-222
references.pmid: 19937232
references.citation: Prog Brain Res. 2001;130:75-87
references.pmid: 11480290
references.citation: Front Integr Neurosci. 2011 Oct 04;5:53
references.pmid: 22065951
references.citation: Nat Neurosci. 2009 Apr;12(4):492-501
references.pmid: 19270688
references.citation: Behav Brain Res. 1997 Mar;84(1-2):81-97
references.pmid: 9079775
references.citation: J Physiol. 1974 Apr;238(2):387-401
references.pmid: 4840852
references.citation: J Physiol. 2004 Apr 1;556(Pt 1):203-19
references.pmid: 14766934
references.citation: Neuron. 2003 Oct 30;40(3):621-30
references.pmid: 14642284
references.citation: Brain Struct Funct. 2007 Sep;212(2):107-19
references.pmid: 17717691
references.citation: Anat Rec (Hoboken). 2010 Jul;293(7):1192-206
references.pmid: 20583263
references.citation: J Neurophysiol. 1992 Oct;68(4):1345-58
references.pmid: 1432088
references.citation: Neuron. 2007 Apr 19;54(2):205-18
references.pmid: 17442243
references.citation: Neuron. 2011 Oct 20;72(2):344-56
references.pmid: 22017992
references.citation: Science. 2002 May 24;296(5572):1480-2
references.pmid: 12029137
references.citation: J Neurophysiol. 2008 Sep;100(3):1245-54
references.pmid: 18562549
references.citation: Neuron. 2011 Oct 6;72(1):111-23
references.pmid: 21982373
references.citation: Trends Neurosci. 1999 Nov;22(11):513-20
references.pmid: 10529819
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19557-62
references.pmid: 19889973
references.citation: J Comp Neurol. 2001 Jan 15;429(3):372-87
references.pmid: 11116226
references.citation: Neuron. 2006 Aug 17;51(4):399-407
references.pmid: 16908406
references.citation: J Neurosci. 2001 Aug 1;21(15):5752-63
references.pmid: 11466447
references.citation: Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11633-8
references.pmid: 9326662
references.citation: J Neurosci. 2010 Feb 3;30(5):1947-67
references.pmid: 20130203
references.citation: Exp Brain Res. 2011 May;210(3-4):377-88
references.pmid: 21286693
references.citation: J Neurophysiol. 2009 Apr;101(4):1836-46
references.pmid: 19109457
references.citation: Neurobiol Learn Mem. 2005 Mar;83(2):134-42
references.pmid: 15721797
references.citation: J Neurophysiol. 2004 Dec;92(6):3244-54
references.pmid: 15306632
references.citation: Neuron. 2009 Dec 24;64(6):841-56
references.pmid: 20064391
references.citation: J Neurophysiol. 2011 Apr;105(4):1950-62
references.pmid: 21307326
references.citation: Somatosens Mot Res. 1996;13(2):115-27
references.pmid: 8844960
references.citation: Annu Rev Neurosci. 2005;28:503-32
references.pmid: 16033324
references.citation: Eur J Neurosci. 2002 Sep;16(6):999-1014
references.pmid: 12383229
references.citation: Trends Neurosci. 2009 Feb;32(2):101-9
references.pmid: 19070909
references.citation: Trends Cogn Sci. 2011 Apr;15(4):177-84
references.pmid: 21414835
references.citation: J Comp Neurol. 2000 May 1;420(2):233-43
references.pmid: 10753309
references.citation: J Neurosci. 2001 Jul 15;21(14):5374-80
references.pmid: 11438614
references.citation: Science. 2010 Nov 26;330(6008):1240-3
references.pmid: 21109671
references.citation: Neuron. 2007 Oct 25;56(2):339-55
references.pmid: 17964250
references.citation: Nat Neurosci. 2006 May;9(5):608-10
references.pmid: 16617340
references.citation: Nature. 2009 Oct 15;461(7266):900-7
references.pmid: 19829369
references.citation: Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10749-53
references.pmid: 8248166
references.citation: Prog Neurobiol. 2004 Nov;74(4):213-47
references.pmid: 15556288
references.citation: Z Naturforsch C J Biosci. 1998 Jul-Aug;53(7-8):542-9
references.pmid: 9840949
references.citation: Nature. 2006 Oct 5;443(7111):525
references.pmid: 17024083
references.citation: Neuron. 2010 Sep 23;67(6):1048-61
references.pmid: 20869600
references.citation: Somatosens Mot Res. 2010;27(3):111-20
references.pmid: 20722492
references.citation: J Neurosci. 2010 Jan 20;30(3):1057-63
references.pmid: 20089914
references.citation: Curr Opin Neurobiol. 2006 Aug;16(4):435-44
references.pmid: 16837190
references.citation: J Neurophysiol. 1997 Aug;78(2):1144-9
references.pmid: 9307141
references.citation: J Comp Neurol. 1992 May 1;319(1):66-84
references.pmid: 1592906
references.citation: Neuron. 2011 Sep 22;71(6):962-73
references.pmid: 21943596
references.citation: J Comp Neurol. 1977 Sep 15;175(2):129-57
references.pmid: 408380
references.citation: PLoS Biol. 2005 May;3(5):e159
references.pmid: 15836427
references.citation: J Neurophysiol. 2005 Jul;94(1):699-711
references.pmid: 15728764
references.citation: Philos Trans R Soc Lond B Biol Sci. 2011 Nov 12;366(1581):3037-48
references.pmid: 21969685
references.citation: J Neurophysiol. 2011 Jul;106(1):332-46
references.pmid: 21525369
references.citation: J Comp Neurol. 2005 Jul 18;488(1):82-100
references.pmid: 15912501
references.citation: J Comp Neurol. 2002 Jan 14;442(3):266-76
references.pmid: 11774341
references.citation: Psychol Rev. 1962 Nov;69:477-91
references.pmid: 13947730
references.citation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Jun;192(6):573-86
references.pmid: 16645885