title: [Historical and current pathophysiological concepts of stress (Tako-Tsubo) cardiomyopathy].
abstract: Tako-Tsubo cardiomyopathy (TTC), also referred to as stress cardiomyopathy (SCM), was first described in the 1990s and is characterized by transient left ventricular dysfunction. Its incidence represents 1-2% of all acute coronary syndromes (ACS). In most cases extreme emotional or physical stress precedes this syndrome. The majority of patients affected are postmenopausal women. Since its first description, various hypotheses regarding the pathophysiology of TTC have been discussed. From a historical perspective, coronary vasospasm has often been proposed as a possible cause of this disorder. However, reviews from numerous registries were able to demonstrate that coronary vasospasm plays only a minor role in the pathogenesis of TTC. Several groups showed disturbances in myocardial microcirculation and energy metabolism in the acute phase of TTC. Nevertheless, with regard to the data currently available, it cannot be differentiated whether these changes are the cause or rather the result of TTC. However, recent concepts include an excessive catecholamine overload and morphological changes which are unequivocally documented in TTC. The relation between elevated catecholamine levels and myocardial dysfunction analogous to TTC could be confirmed in animal experiments.In summary, it can be assumed that TTC is caused by an excessive cardiotoxic release of catecholamines. Ventricular dysfunction can be explained by increased numbers of β-adrenergic receptors in the apex, leading to greater vulnerability to catecholamine overload. Individual anatomical differences in the sympathoadrenergic system and distribution from β-adrenergic receptors are presumably responsible for the interindividual occurrence of wall motion abnormalities in TTC.
authors.affiliation: Abteilung Kardiologie, Kerckhoff-Klinik Herz- und Thoraxzentrum, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Szardien
authors.forename: H
authors.initials: H
authors.lastname: Möllmann
authors.forename: A
authors.initials: A
authors.lastname: Elsässer
authors.forename: C W
authors.initials: CW
authors.lastname: Hamm
authors.forename: H M
authors.initials: HM
authors.lastname: Nef
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D054549:Takotsubo Cardiomyopathy / Q000503:physiopathology*
chemical_list: D002395:Catecholamines; D011943:Receptors, Adrenergic, beta
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