title: Relationship between paraglottic space invasion and cervical lymph node metastasis in patients undergoing supracricoid partial laryngectomy.
abstract: BACKGROUND
  To investigate the relationship between paraglottic space (PGS) invasion and lymph node metastasis in patients undergoing supracricoid partial laryngectomy.
  
  
  METHODS
  The study included 98 subjects with squamous cell carcinoma of the glottis.
  
  
  RESULTS
  The PGS invasion rate was 60.2% (59/98), and a significant correlation was found between PGS invasion and cervical lymph node metastasis (p = .022). Fifteen of the 59 patients (25.4%) with PGS invasion, only 3 of the 39 patients (7.7%) without any evidence of PGS invasion had lymph node metastasis. Furthermore, a significant correlation was also found between PGS invasion and T classification (p < .001), vocal cord mobility (p < .001), and subglottic extension (p = .014), and patients with no evidence of PGS invasion possibly had a survival benefit (5-year disease-specific survival rate, 84% vs 64%; p = .118).
  
  
  CONCLUSIONS
  This study shows that PGS invasion is significantly related to cervical lymph node metastasis in patients undergoing supracricoid partial laryngectomy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Joo
authors.forename: Jun-Ook
authors.initials: JO
authors.lastname: Park
authors.forename: Kwang-Jae
authors.initials: KJ
authors.lastname: Cho
authors.forename: Min-Sik
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D003238:Connective Tissue / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D016019:Survival Analysis