title: Bioactive glass-based scaffolds for bone tissue engineering.
abstract: Originally developed to fill and restore bone defects, bioactive glasses are currently also being intensively investigated for bone tissue engineering applications. In this chapter, we review and discuss current knowledge on porous bone tissue engineering scaffolds made from bioactive silicate glasses. A brief historical review and the fundamental requirements in the field of bone tissue engineering scaffolds will be presented, followed by a detailed overview of recent developments in bioactive glass-based scaffolds. In addition, the effects of ionic dissolution products of bioactive glasses on osteogenesis and angiogenic properties of scaffolds are briefly addressed. Finally, promising areas of future research and requirements for the advancement of the field are highlighted and discussed.
authors.affiliation: Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstr. 6, 91058, Erlangen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Will
authors.forename: Lutz-Christian
authors.initials: LC
authors.lastname: Gerhardt
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D018786:Bone Substitutes / Q000138:chemical synthesis*; D005898:Glass / Q000737:chemistry*; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D011474:Prosthesis Design; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes