title: High-performance image reconstruction in fluorescence tomography on desktop computers and graphics hardware.
abstract: Image reconstruction in fluorescence optical tomography is a three-dimensional nonlinear ill-posed problem governed by a system of partial differential equations. In this paper we demonstrate that a combination of state of the art numerical algorithms and a careful hardware optimized implementation allows to solve this large-scale inverse problem in a few seconds on standard desktop PCs with modern graphics hardware. In particular, we present methods to solve not only the forward but also the non-linear inverse problem by massively parallel programming on graphics processors. A comparison of optimized CPU and GPU implementations shows that the reconstruction can be accelerated by factors of about 15 through the use of the graphics hardware without compromising the accuracy in the reconstructed images.
authors.forename: Manuel
authors.initials: M
authors.lastname: Freiberger
authors.forename: Herbert
authors.initials: H
authors.lastname: Egger
authors.forename: Manfred
authors.initials: M
authors.lastname: Liebmann
authors.forename: Hermann
authors.initials: H
authors.lastname: Scharfetter
references.citation: Opt Express. 1999 May 10;4(10):353-71
references.pmid: 19396292
references.citation: Appl Opt. 1998 Aug 1;37(22):5337-43
references.pmid: 18286015
references.citation: Med Phys. 2005 Apr;32(4):992-1000
references.pmid: 15895582
references.citation: Phys Med Biol. 2005 Sep 7;50(17):4225-41
references.pmid: 16177541
references.citation: Opt Express. 2010 Sep 13;18(19):20201-14
references.pmid: 20940911
references.citation: J Appl Physiol. 1976 Apr;40(4):575-83
references.pmid: 776922
references.citation: J Photochem Photobiol B. 1992 May 15;13(3-4):307-14
references.pmid: 1506994
references.citation: J Biomed Opt. 2010 Nov-Dec;15(6):066009
references.pmid: 21198183
references.citation: Phys Med Biol. 2007 Feb 7;52(3):577-87
references.pmid: 17228106
references.citation: Opt Express. 2004 Nov 1;12(22):5402-17
references.pmid: 19484100
references.citation: IEEE Trans Biomed Eng. 2010 Nov;57(11):
references.pmid: 20562032
references.citation: Opt Express. 2002 Dec 30;10(26):1557-62
references.pmid: 19461692
references.citation: Lasers Surg Med. 2004;35(5):342-8
references.pmid: 15611954
references.citation: Phys Med Biol. 2005 May 21;50(10):2365-86
references.pmid: 15876673
references.citation: Appl Opt. 1988 May 1;27(9):1820-4
references.pmid: 20531660
references.citation: Appl Opt. 1995 Nov 1;34(31):7395-409
references.pmid: 21060614