title: Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5'-untranslated region.
abstract: Coinfection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) accelerates hepatitis C disease progression; however, the mechanism underlying this effect is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV gene expression. We further revealed that Rev binds to the internal loop of the HCV 5'-untranslated region (5'-UTR) to stimulate HCV IRES-mediated translation.
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Weiyong
authors.initials: W
authors.lastname: Liu
authors.forename: Youxing
authors.initials: Y
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Ding
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Yingle
authors.initials: Y
authors.lastname: Liu
authors.forename: Zishu
authors.initials: Z
authors.lastname: Pan
authors.forename: Biao
authors.initials: B
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wu
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D001120:Arginine; D001483:Base Sequence; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D015497:HIV-1; D016174:Hepacivirus / Q000235:genetics*; D008969:Molecular Sequence Data; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D015854:Up-Regulation / Q000235:genetics; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020121:5' Untranslated Regions; D012367:RNA, Viral; D054321:rev Gene Products, Human Immunodeficiency Virus; C514860:rev protein, Human Immunodeficiency Virus-1; D001120:Arginine