title: Synthesis and study of new paramagnetic resveratrol analogues.
abstract: New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNFα production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents.
authors.affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, H-7602 Pécs, PO Box 99, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Kálai
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Borza
authors.forename: Csenge
authors.initials: C
authors.lastname: Antus
authors.forename: Balázs
authors.initials: B
authors.lastname: Radnai
authors.forename: Gergely
authors.initials: G
authors.lastname: Gulyás-Fekete
authors.forename: Andrea
authors.initials: A
authors.lastname: Fehér
authors.forename: Balázs
authors.initials: B
authors.lastname: Sümegi
authors.forename: Kálmán
authors.initials: K
authors.lastname: Hideg
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000378:metabolism; D002460:Cell Line; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D052160:Benzothiazoles; D016166:Free Radical Scavengers; D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D013267:Stilbenes; D013451:Sulfonic Acids; D014409:Tumor Necrosis Factor-alpha; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D000077185:Resveratrol