title: Competing risk of atherosclerotic risk factors for arterial and venous thrombosis in a general population: the Tromso study.
abstract: OBJECTIVE
  To investigate and compare the impact of traditional atherosclerotic risk factors for the risk of arterial and venous thrombosis, taking into account competing risks.
  
  
  RESULTS
  In 1994-1995, 26,185 subjects were screened in the Tromsø study. Information on traditional atherosclerotic risk factors was obtained by physical examination, blood samples, and questionnaires. Subjects were followed to the first incident event of myocardial infarction (MI) or venous thromboembolism (VTE), or December 31, 2005. During a median of 10.8 years of follow-up, there were 1279 cases of incident MI and 341 VTE events. Advancing age and high body mass index were both associated with MI and VTE. Hazard ratio per decade of age was 2.34 (95% CI: 2.25-2.43) for MI and 1.87 (1.74-2.01) for VTE, and 3 kg/m(2) increase in body mass index was associated with 1.16 (1.11-1.21) and 1.20 (1.12-1.29) increased risk of MI and VTE, respectively. Blood pressure, high levels of triglycerides and total cholesterol, low HDL cholesterol, self-reported diabetes, and smoking were all associated with increased risk of MI but not associated with VTE.
  
  
  CONCLUSIONS
  Our findings imply that traditional atherosclerotic risk factors, such as smoking, hypertension, dyslipidemia, and diabetes mellitus are not shared by arterial and venous thrombosis.
authors.affiliation: Hematological Research Group, Department of Clinical Medicine, University of Tromsø, N-9037 Tromsø, Norway. sigrid.brakkan@uit.no
authors.forename: Sigrid K
authors.initials: SK
authors.lastname: Brækkan
authors.forename: Erin M
authors.initials: EM
authors.lastname: Hald
authors.forename: Ellisiv B
authors.initials: EB
authors.lastname: Mathiesen
authors.forename: Inger
authors.initials: I
authors.lastname: Njølstad
authors.forename: Tom
authors.initials: T
authors.lastname: Wilsgaard
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: John-Bjarne
authors.initials: JB
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications / Q000150:complications* / Q000208:ethnology; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000208:ethnology; D009664:Norway / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014280:Triglycerides / Q000097:blood; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000208:ethnology
chemical_list: D014280:Triglycerides; D002784:Cholesterol