title: Prognostic significance of preoperative blood transfusion in stomach cancer.
abstract: OBJECTIVE
  We did a retrospective study to understand the prognostic effects of preoperative blood transfusions in stomach cancer surgery.
  
  
  METHODS
  Data for 1,360 patients who underwent gastrectomy for stomach cancer between 2001 and 2009 were retrospectively reviewed. We analyzed factors that affect preoperative transfusion and clinicopathologic features. We also analyzed 5-year and overall survival rates of the transfusion and non transfusion subgroups.
  
  
  RESULTS
  Sixty patients (4.4%) required blood transfusion within the preoperative period. The transfused group included patients who took aspirin or clopidogrel (P<0.001), with more advanced T stages (P<0.001), with more advanced nodal metastasis (P=0.00), and with more advanced stages (P=0.00) than the non transfusion group. On multivariate analysis, preoperative transfusion was a statistically significant negative influence on 5-year survival and overall survival rates (58.2% vs 79.9% (P=0.00), 58.2% vs 76.8% (P=0.00)). Applying Cox-regression analyses, blood transfusion did appear to have an effect on prognosis and on 5-year and overall survival rates.
  
  
  CONCLUSIONS
  We found a direct negative relation between preoperative transfusion and long term prognosis in patients receiving gastric cancer surgery.
authors.affiliation: Department of Surgery, Research Institute for Medical Science, Chungnam National Universuty School of Medicine, Daejeon, Korea.
authors.forename: Seok Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Sang-Il
authors.initials: SI
authors.lastname: Lee
authors.forename: Seung-Moo
authors.initials: SM
authors.lastname: Noh
references.citation: Cancer. 1990 Dec 1;66(11):2331-5
references.pmid: 2245388
references.citation: Lancet. 1996 Oct 19;348(9034):1055-60
references.pmid: 8874456
references.citation: Circulation. 1998 Feb 17;97(6):562-8
references.pmid: 9494026
references.citation: Br Med J (Clin Res Ed). 1986 Aug 30;293(6546):537-8
references.pmid: 3092905
references.citation: Arch Otolaryngol Head Neck Surg. 1987 Mar;113(3):307-10
references.pmid: 3814377
references.citation: J Chronic Dis. 1987;40(5):373-83
references.pmid: 3558716
references.citation: Arch Pathol Lab Med. 1998 Feb;122(2):145-51
references.pmid: 9499357
references.citation: Anesthesiology. 1996 Mar;84(3):732-47
references.pmid: 8659805
references.citation: J Gastrointest Surg. 2002 Sep-Oct;6(5):753-62
references.pmid: 12399066
references.citation: Neurosurgery. 2006 Oct;59(4):775-9; discussion 779-80
references.pmid: 17038943
references.citation: Lancet. 1974 Sep 21;2(7882):696-8
references.pmid: 4142966
references.citation: Zentralbl Chir. 2003 Nov;128(11):970-6
references.pmid: 14669119
references.citation: Am J Surg. 1994 Feb;167(2):256-60
references.pmid: 8135315
references.citation: Cochrane Database Syst Rev. 2006 Jan 25;(1):CD005033
references.pmid: 16437512
references.citation: Br J Surg. 1988 Apr;75(4):377-9
references.pmid: 3359155
references.citation: Clin Orthop Relat Res. 1998 Dec;(357):30-5
references.pmid: 9917697
references.citation: JAMA. 1988 Nov 11;260(18):2700-3
references.pmid: 3054179
references.citation: J Surg Oncol. 1984 Oct;27(2):124-30
references.pmid: 6482458
references.citation: Am J Surg. 1985 Apr;149(4):502-7
references.pmid: 2984952
references.citation: Ann Surg Oncol. 2002 Jan-Feb;9(1):5-12
references.pmid: 11829431
references.citation: HPB Surg. 1994;8(1):1-6; discussion 6-7
references.pmid: 7993858
references.citation: World J Surg. 1989 Sep-Oct;13(5):637-43
references.pmid: 2683404
references.citation: Surgery. 2001 Apr;129(4):433-9
references.pmid: 11283534
references.citation: Br J Haematol. 2001 Apr;113(1):24-31
references.pmid: 11328275
references.citation: Br J Anaesth. 1998 Dec;81 Suppl 1:20-4
references.pmid: 10318984
references.citation: Crit Care Med. 2002 Oct;30(10):2249-54
references.pmid: 12394952
references.citation: Surgery. 1988 Jun;103(6):665-70
references.pmid: 3375993
references.citation: Br J Haematol. 2006 Dec;135(5):634-41
references.pmid: 17107347
references.citation: Transfusion. 1998 Nov-Dec;38(11-12):1104-14
references.pmid: 9838944
references.citation: Transfusion. 1987 Sep-Oct;27(5):375-7
references.pmid: 3629666