title: Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging.
abstract: Arterial spin labeling perfusion MRI can suffer from artifacts and quantification errors when the time delay between labeling and arrival of labeled blood in the tissue is uncertain. This transit delay is particularly uncertain in broad clinical populations, where reduced or collateral flow may occur. Measurement of transit delay by acquisition of the arterial spin labeling signal at many different time delays typically extends the imaging time and degrades the sensitivity of the resulting perfusion images. Acquisition of transit delay maps at the same spatial resolution as perfusion images may not be necessary, however, because transit delay maps tend to contain little high spatial resolution information. Here, we propose the use of a reduced spatial resolution arterial spin labeling prescan for the rapid measurement of transit delay. Approaches to using the derived transit delay information to optimize and quantify higher resolution continuous arterial spin labeling perfusion images are described. Results in normal volunteers demonstrate heterogeneity of transit delay across different brain regions that lead to quantification errors without the transit maps and demonstrate the feasibility of this approach to perfusion and transit delay quantification.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. wdai@bidmc.harvard.edu
authors.forename: Weiying
authors.initials: W
authors.lastname: Dai
authors.forename: Philip M
authors.initials: PM
authors.lastname: Robson
authors.forename: Ajit
authors.initials: A
authors.lastname: Shankaranarayanan
authors.forename: David C
authors.initials: DC
authors.lastname: Alsop
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
references.citation: Magn Reson Med. 2004 Sep;52(3):679-82
references.pmid: 15334591
references.citation: Magn Reson Med. 1995 Aug;34(2):156-60
references.pmid: 7476073
references.citation: J Magn Reson Imaging. 2005 Jun;21(6):676-82
references.pmid: 15906323
references.citation: Magn Reson Med. 2006 Feb;55(2):219-32
references.pmid: 16416430
references.citation: Magn Reson Med. 2004 Jul;52(1):131-40
references.pmid: 15236376
references.citation: J Cereb Blood Flow Metab. 1996 Nov;16(6):1236-49
references.pmid: 8898697
references.citation: Magn Reson Med. 2001 Jan;45(1):71-9
references.pmid: 11146488
references.citation: Magn Reson Med. 2002 Aug;48(2):242-54
references.pmid: 12210932
references.citation: Magn Reson Med. 2008 Dec;60(6):1488-97
references.pmid: 19025913
references.citation: Radiology. 2010 Nov;257(2):507-15
references.pmid: 20959548
references.citation: Magn Reson Med. 1998 Sep;40(3):348-55
references.pmid: 9727936
references.citation: Neurology. 1998 Mar;50(3):633-41
references.pmid: 9521248
references.citation: Magn Reson Med. 1998 Sep;40(3):383-96
references.pmid: 9727941
references.citation: J Cereb Blood Flow Metab. 1985 Mar;5(1):65-9
references.pmid: 3871783
references.citation: Magn Reson Med. 1997 Oct;38(4):527-33
references.pmid: 9324317
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: AJNR Am J Neuroradiol. 2010 Nov;31(10):1892-4
references.pmid: 20110375
references.citation: Magn Reson Med. 2000 May;43(5):739-46
references.pmid: 10800040
references.citation: Neuroimaging Clin N Am. 2006 Feb;16(1):149-67, ix
references.pmid: 16543090
references.citation: Magn Reson Med. 2001 Nov;46(5):974-84
references.pmid: 11675650
references.citation: Stroke. 2000 Mar;31(3):680-7
references.pmid: 10700504
references.citation: J Magn Reson. 1998 Jul;133(1):200-3
references.pmid: 9654487
references.citation: Magn Reson Med. 2010 Apr;63(4):1111-8
references.pmid: 20373414
references.citation: Magn Reson Med. 2000 Jul;44(1):92-100
references.pmid: 10893526
references.citation: Magn Reson Med. 2010 Mar;63(3):641-7
references.pmid: 20146233
references.citation: Magn Reson Med. 1997 Nov;38(5):828-33
references.pmid: 9358458
references.citation: Magn Reson Med. 2003 Sep;50(3):599-607
references.pmid: 12939768
references.citation: Magn Reson Med. 1999 Jun;41(6):1246-54
references.pmid: 10371458
references.citation: Magn Reson Med. 2006 Jun;55(6):1334-41
references.pmid: 16700025
references.citation: J Magn Reson Imaging. 2005 Jul;22(1):13-22
references.pmid: 15971174
references.citation: Magn Reson Med. 2003 Jul;50(1):145-53
references.pmid: 12815689
references.citation: J Cereb Blood Flow Metab. 2007 Feb;27(2):404-13
references.pmid: 16736045
references.citation: Ann Neurol. 2000 Jan;47(1):93-100
references.pmid: 10632106
references.citation: Magn Reson Med. 1996 Oct;36(4):562-6
references.pmid: 8892208
references.citation: Magn Reson Med. 1999 Dec;42(6):1098-105
references.pmid: 10571931
references.citation: Magn Reson Med. 1997 Feb;37(2):226-35
references.pmid: 9001147
references.citation: Magn Reson Med. 2005 Aug;54(2):366-72
references.pmid: 16032674
references.citation: AJNR Am J Neuroradiol. 2008 Aug;29(7):1228-34
references.pmid: 18372417
references.citation: Stroke. 2002 Apr;33(4):1146-51
references.pmid: 11935075
references.citation: Magn Reson Med. 2007 Jul;58(1):41-54
references.pmid: 17659615
references.citation: Magn Reson Med. 2003 Dec;50(6):1296-301
references.pmid: 14648578
references.citation: Magn Reson Med. 1998 May;39(5):702-8
references.pmid: 9581600
references.citation: NMR Biomed. 2007 Oct;20(6):566-77
references.pmid: 17221937