title: Significant correlation between visceral adiposity and high-sensitivity C-reactive protein (hs-CRP) in Japanese subjects.
abstract: OBJECTIVE
  High-sensitivity C-reactive protein (hs-CRP) is a marker for low-grade inflammation, as well as atherosclerosis, obesity, hyperglycemia and hypertension. Because the factor showing the strongest association with inflammation is currently unknown, we investigated the associations between hs-CRP and clinical and biochemical characteristics in Japanese subjects with mild obesity or impaired glucose tolerance.
  
  
  METHODS
  Subjects aged <65 years old, attending the Seirei Medical Examination Center, underwent complete physical and laboratory examinations. A total of 112 subjects (mean age 59.9±5.9 years old, males/females: n=50/62) with a waist circumference of >85 cm in males and >90 cm in females, homeostasis model assessment-insulin resistance (HOMA-IR) ≥1.7, or impaired glucose tolerance were eligible for this study. All subjects had normal albuminuria.
  
  
  RESULTS
  Log-transformed hs-CRP concentrations were significantly correlated with BMI (r=0.278, p<0.01), HOMA-IR (r=0.296, p<0.005), 2-h post-challenge IRI during an oral glucose tolerance test (r=0.218, p<0.05), maximum intima-media thickness (r=0.240, p<0.05), visceral fat area evaluated by computed tomography (r=0.423, p<0.0001) and subcutaneous fat area (r=0.231, p<0.05). Multiple linear regression analysis showed that visceral fat was the most significantly correlated factor with hs-CRP.
  
  
  CONCLUSIONS
  Visceral fat mass was a significant and independent predictor for serum hs-CRP levels in Japanese subjects with mild obesity and/or impaired glucose tolerance.
authors.affiliation: The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuriya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Tetsu
authors.initials: T
authors.lastname: Morioka
authors.forename: Norio
authors.initials: N
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ito
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Oki
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D050154:Adiposity / Q000502:physiology*; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000473:pathology; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000473:pathology*; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood / Q000473:pathology; D011237:Predictive Value of Tests; D050507:Subcutaneous Fat, Abdominal / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein