title: [The analysis of effect of Th1/Th2 cytokine in the different prognosis in severe influenza A (H1N1)].
abstract: OBJECTIVE
  To explore the effect of cytokine in the different prognosis of patients with severe influenza A (H1N1) infection.
  
  
  METHODS
  28 cases with severe influenza A (H1N1) were enrolled in the study including 16 cured cases and 12 dead cases. The cytokine level in serum was detected by Luminex technology.
  
  
  RESULTS
  The levels of IL-2, IL-12 (P70) and IFN-gamma in dead group was lower than cured and normal control group and the difference were significant, P <0.05, respectively. IL-4 level in the dead group was significantly lower than cured group and normal control group, P value was 0.0310 and 0.0012, respectively.
  
  
  CONCLUSIONS
  The Thl cytokine level in the severe 2009 epidemic H1N1 influeaze cases shows decreased trend, and the trend is more obvious in dead cases. The decrease of Th1 cytokine may be one of reasons leading to severe clinical situation and related withthe bad prognosis.
authors.affiliation: Beijing Yuan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Da-yan
authors.initials: DY
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Yan
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Dan-tong
authors.initials: DT
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Zi-kang
authors.initials: ZK
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D016207:Cytokines / Q000097:blood / Q000276:immunology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality / Q000821:virology; D011379:Prognosis; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines