title: Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: interchangeable cancer promoters.
abstract: BACKGROUND
  Several groups are researching cancers, and showing that hCGβ is a promoter of cancer growth and malignancy. Recent research shows that some hCGβ is present as Hyperglycosylated hCGβ. Other groups studied Hyperglycosylated hCG as a promoter of choriocarcinoma and germ cell malignancies. The question therefore arises, are Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ interrelated or interchangable promoters of cancer?
  
  
  METHODS
  The actions of Hyperglycosylated hCGβ, hCGβ and Hyperglycosylated hCG are investigated in 7 cell lines, Jar and JEG-3 choriocarcinoma cell lines, NTERA germ cell cancer line, SCaBER and T24 bladder epithelial carcinoma lines, KLE and Hec-1-a endometrial adenocarcinoma and epithelial carcinoma cell lines. Actions of promoters on cell growth are investigated.
  
  
  RESULTS
  The actions of Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ appear to be interchangeable in all cell lines investigated.
  
  
  CONCLUSIONS
  All hCG-related cancer promoters seem interrelated, working through a similar mechanism, antagonism of apoptosis through know receptors such as TGFβ receptors in all cancers studied.
authors.affiliation: USA hCG Reference Service, Department of Obstetrics and Gynecology, Health Sciences Center MSC10-5580, 1 University of New Mexico, Albuquerque, NM 87104, USA. larry@hcglab.com
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Cole
authors.forename: Stephen
authors.initials: S
authors.lastname: Butler
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D017209:Apoptosis / Q000187:drug effects; D002452:Cell Count; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002822:Choriocarcinoma / Q000378:metabolism / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D006031:Glycosylation; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D013736:Testicular Neoplasms; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human