title: α-glucosidase inhibitors from plants: A natural approach to treat diabetes.
abstract: Diabetes is a common metabolic disease characterized by abnormally high plasma glucose levels, leading to major complications, such as diabetic neuropathy, retinopathy, and cardiovascular diseases. One of the effective managements of diabetes mellitus, in particular, non-insulin-dependent diabetes mellitus (NIDDM) to decrease postprandial hyperglycemia, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as α-glucosidase and α-amylase, in the digestive organs. α-Glucosidase is the key enzyme catalyzing the final step in the digestive process of carbohydrates. Hence, α-glucosidase inhibitors can retard the liberation of d-glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postprandial hyperglycemia. In recent years, many efforts have been made to identify effective α-glucosidase inhibitors from natural sources in order to develop a physiologic functional food or lead compounds for use against diabetes. Many α-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants. In the present review, we focus on the constituents isolated from different plants having α-glucosidase inhibitory potency along with IC50 values.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra - 136 119, Haryana, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.forename: Smita
authors.initials: S
authors.lastname: Narwal
authors.forename: Vipin
authors.initials: V
authors.lastname: Kumar
authors.forename: Om
authors.initials: O
authors.lastname: Prakash
references.citation: J Nat Prod. 1998 Nov;61(11):1413-5
references.pmid: 9834167
references.citation: J Am Chem Soc. 2004 Jan 14;126(1):187-93
references.pmid: 14709083
references.citation: Biosci Biotechnol Biochem. 2007 Jan;71(1):69-76
references.pmid: 17213665
references.citation: J Am Soc Mass Spectrom. 2009 Aug;20(8):1496-503
references.pmid: 19443236
references.citation: Phytochemistry. 2008 Mar;69(5):1173-8
references.pmid: 18221760
references.citation: Chem Pharm Bull (Tokyo). 2002 Jan;50(1):112-4
references.pmid: 11824569
references.citation: J Ethnopharmacol. 2006 Dec 6;108(3):445-9
references.pmid: 16872768
references.citation: J Agric Food Chem. 2002 Dec 4;50(25):7244-8
references.pmid: 12452639
references.citation: J Nat Med. 2008 Jul;62(3):349-53
references.pmid: 18409066
references.citation: Fitoterapia. 2006 Dec;77(7-8):568-73
references.pmid: 17071014
references.citation: J Biol Chem. 1975 Oct 10;250(19):7802-9
references.pmid: 1176448
references.citation: Eur J Med Chem. 2006 Feb;41(2):213-8
references.pmid: 16387392
references.citation: Phytochemistry. 2008 May;69(8):1726-31
references.pmid: 18400239
references.citation: J Agric Food Chem. 2008 Jun 25;56(12):4367-71
references.pmid: 18498168
references.citation: J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):149-53
references.pmid: 16802696
references.citation: Yakugaku Zasshi. 2001 May;121(5):371-8
references.pmid: 11360491
references.citation: Biol Pharm Bull. 2006 Feb;29(2):302-5
references.pmid: 16462036
references.citation: Carbohydr Res. 2008 May 19;343(7):1278-81
references.pmid: 18374320
references.citation: Appl Microbiol Biotechnol. 2004 Feb;63(6):613-25
references.pmid: 14669056
references.citation: Bioorg Med Chem. 2008 Mar 15;16(6):2912-20
references.pmid: 18194870
references.citation: Carbohydr Res. 1994 Feb 3;253:235-45
references.pmid: 8156550
references.citation: Phytochemistry. 2007 Mar;68(5):591-5
references.pmid: 17270224
references.citation: Phytochemistry. 2008 Sep;69(12):2347-53
references.pmid: 18639907
references.citation: Biochem J. 1974 Apr;139(1):285-8
references.pmid: 4463948
references.citation: Food Chem. 2008 Jun 1;108(3):965-72
references.pmid: 26065759
references.citation: Plant Foods Hum Nutr. 2008 Dec;63(4):163-9
references.pmid: 18958624
references.citation: J Chem Ecol. 1996 Oct;22(10):1877-99
references.pmid: 24227114
references.citation: Fitoterapia. 2001 Aug;72(6):686-8
references.pmid: 11543970
references.citation: J Agric Food Chem. 2006 Jun 28;54(13):4588-92
references.pmid: 16787002
references.citation: Chem Pharm Bull (Tokyo). 2004 Jul;52(7):785-9
references.pmid: 15256696
references.citation: Nat Rev Drug Discov. 2005 May;4(5):367-8
references.pmid: 15902771
references.citation: Curr Med Chem. 2006;13(10):1203-18
references.pmid: 16719780
references.citation: Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1362-5
references.pmid: 11605673
references.citation: J Ethnopharmacol. 2007 Jan 3;109(1):48-53
references.pmid: 16920301
references.citation: J Ethnopharmacol. 2006 Oct 11;107(3):449-55
references.pmid: 16678367
references.citation: Diabetes Care. 1999 Jun;22(6):960-4
references.pmid: 10372249
references.citation: Phytochemistry. 2008 Nov;69(16):2820-5
references.pmid: 18951591
references.citation: Endocrinol Metab Clin North Am. 1997 Sep;26(3):539-51
references.pmid: 9314014
references.citation: Bioorg Med Chem. 2009 Jul 15;17(14):5170-5
references.pmid: 19515570
references.citation: J Nutr Sci Vitaminol (Tokyo). 2003 Oct;49(5):346-9
references.pmid: 14703310
references.citation: J Nat Prod. 2008 Dec;71(12):2068-72
references.pmid: 19061390
references.citation: Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):298-301
references.pmid: 17441354
references.citation: Biosci Biotechnol Biochem. 2007 May;71(5):1130-5
references.pmid: 17485835
references.citation: World J Gastroenterol. 2001 Apr;7(2):270-4
references.pmid: 11819773
references.citation: J Agric Food Chem. 2001 Apr;49(4):1952-6
references.pmid: 11308352
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):166-72
references.pmid: 17537687
references.citation: Biosci Biotechnol Biochem. 2003 Feb;67(2):445-7
references.pmid: 12729019
references.citation: Nutrition. 2005 Jun;21(6):756-61
references.pmid: 15925302
references.citation: Fitoterapia. 2008 Sep;79(6):456-7
references.pmid: 18508205
references.citation: Diabetes Res Clin Pract. 2007 Jul;77(1):41-6
references.pmid: 17098323
references.citation: Tetrahedron. 1968 Mar;24(5):2125-44
references.pmid: 5636917
references.citation: J Agric Food Chem. 2004 May 5;52(9):2541-5
references.pmid: 15113153
references.citation: Biochim Biophys Acta. 1985 Apr 29;828(3):213-21
references.pmid: 3872681
references.citation: J Ethnopharmacol. 2008 Feb 28;116(1):27-32
references.pmid: 18082348
references.citation: Carbohydr Res. 2004 Apr 28;339(6):1035-40
references.pmid: 15063189
references.citation: J Enzyme Inhib Med Chem. 2009 Feb;24(1):65-9
references.pmid: 18615280
references.citation: Phytochemistry. 2007 Aug;68(15):2096-100
references.pmid: 17434189
references.citation: J Ethnopharmacol. 2009 Jul 30;124(3):619-24
references.pmid: 19422900