title: Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.
abstract: Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of growth factors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite outgrowth. Recent studies have also revealed the role of CS/DS chains in the orchestration of the neural stem/progenitor cell micromilieu. Individual functional proteins recognize a set of multiple overlapping oligosaccharide sequences decorated to give different sulfation patterns, which are termed here "wobble CS/DS oligosaccharide motifs," and induce signaling pathways essential for the proliferation, self-renewal, and cell lineage commitment of neural stem/progenitor cells.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. anuragp@uab.edu
authors.forename: Anurag
authors.initials: A
authors.lastname: Purushothaman
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
authors.forename: Andreas
authors.initials: A
authors.lastname: Faissner
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002809:Chondroitin Sulfates / Q000378:metabolism*; D003871:Dermatan Sulfate / Q000378:metabolism*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D011509:Proteoglycans; D003871:Dermatan Sulfate; D002809:Chondroitin Sulfates
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