title: Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation.
abstract: While several models have proven to result in accurate estimations when measuring cardiac output using indicator dilution, the mono-exponential model has primarily been chosen for deriving coronary blood/plasma volume. In this study, we compared four models to derive coronary plasma volume using indicator dilution; the mono-exponential, power-law, gamma-variate, and local density random walk (LDRW) model. In anesthetized goats (N = 14), we determined the distribution volume of high molecular weight (2,000 kDa) dextrans. A bolus injection (1.0 ml, 0.65 mg/ml) was given intracoronary and coronary venous blood samples were taken every 0.5-1.0 s; outflow curves were analyzed using the four aforementioned models. Measurements were done at baseline and during adenosine infusion. Absolute coronary plasma volume estimates varied by ~25% between models, while the relative volume increase during adenosine infusion was similar for all models. The gamma-variate, LDRW, and mono-exponential model resulted in volumes corresponding with literature, whereas the power-model seemed to overestimate the coronary plasma volume. The gamma-variate and LDRW model appear to be suitable alternative models to the mono-exponential model to analyze coronary indicator-dilution curves, particularly since these models are minimally influenced by outliers and do not depend on data of the descending slope of the curve only.
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: Judith
authors.initials: J
authors.lastname: Brands
authors.forename: Hans
authors.initials: H
authors.lastname: Vink
authors.forename: Jurgen W G E
authors.initials: JW
authors.lastname: Van Teeffelen
mesh_terms: D000241:Adenosine; D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006041:Goats; D006439:Hemodynamics / Q000502:physiology; D007201:Indicator Dilution Techniques; D008955:Models, Cardiovascular; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine
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