title: Determination of trace elements in patients with chronic hepatitis B.
abstract: Chronic hepatitis B virus (HBV) infection is a major liver disease worldwide and its clinical manifestations are linked to immune response. The purpose of this study was to evaluate the relationship between selenium, copper, and zinc in comparison with transaminase level in chronic HBV patients. Serum samples of the HBV infected patients were obtained from Tooba medical center, Sari, Iran. Sixty patients were enrolled in this study (36 men and 24 women), mean age: 39.6 ± 12.2 years. The concentration of zinc, selenium, copper and transaminases were determined using an autoanalyzer system. Concentrations of selenium (0.273 ± 0.056 μg/dl) and zinc (2.1 ± 0.037) was elevated in patients with low transaminase levels as were significantly different in comparison with patients with high transaminase level (P<0.05). Serum copper concentration was similar in two groups of patients. Elevated levels of transaminase concentrations were independently associated with low zinc and selenium concentrations in chronic HBV patients. It is concluded that serum zinc and selenium levels are associated with less hepatic damage in chronic HBV patients and might have a protective role during liver injury.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, Mazandaran University of medical Sciences, Sari, Iran. abedianks@razi.tums.ac.ir
authors.forename: Saeid
authors.initials: S
authors.lastname: Abediankenari
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Nasehi
authors.forename: Siavash
authors.initials: S
authors.lastname: Abedi
authors.forename: Vahid
authors.initials: V
authors.lastname: Hosseini
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D003300:Copper / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D006801:Humans; D007492:Iran; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D015415:Biomarkers; D014131:Trace Elements; D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012643:Selenium; D015032:Zinc