title: Measurement of gastric emptying time of solids in healthy subjects using scintigraphic method: a revised technique.
abstract: The gastric emptying half time (GET) of solid food in 24 healthy volunteers (11M/13F) was evaluated using a revised technique and a gamma camera scan. Within 20 min and after 8 h of fasting, each volunteer ate two pieces of toast with a two-egg-omelette that was mixed with 18.5 MBq (99m)Tc-labelled phytate. The raw data were analysed in the MATLAB program to establish the gastric intestine tract (GI tract) biokinetic model. The GI tract model defines the metabolic mechanism with reference to five compartments, which are stomach, body fluid, small intestine (SI), upper large intestine and lower large intestine, according to the ICRP-30 report. The model was expressed using four simultaneous time-dependent differential equations. The gastric emptying half-time and T(1/2eff)(SI) of males were 62.6±15.4 and 149.8±204.1 min, respectively, and those of females were 98.8±16.3 and 131.6±38.4 min.
authors.affiliation: Graduate Institute of Radiological Science,  Central Taiwan University of Science and Technology, Takun, Taichung 406,  Taiwan.
authors.forename: Chia Chun
authors.initials: CC
authors.lastname: Hsu
authors.forename: Pei Yu
authors.initials: PY
authors.lastname: Chen
authors.forename: Chang Chi
authors.initials: CC
authors.lastname: Chen
authors.forename: Lung Kwang
authors.initials: LK
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010833:Phytic Acid / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values; D013270:Stomach / Q000000981:diagnostic imaging*; D013667:Technetium / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D013667:Technetium; D010833:Phytic Acid