title: Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.
abstract: The progression of atherosclerosis remains a major cause of morbidity and mortality. Plaque formation is an immunological response driven by a number of risk factors, and reduction of risk is the primary goal of treatment. The role of LDL-C is well established and statins have proved effective drugs, although the relative risk reduction is only around 30%. The importance of other factors-notably low HDL-C and high TGs-has become increasingly clear and the search for alternative strategies continues. Niacin is particularly effective in achieving normalization of HDL-C but is clinically underutilized due to the side effect of cutaneous flushing. The discovery that flushing is mediated by mechanisms distinct from the lipid-lowering effects has led to the development of combination drugs with reduced side effects. This review considers the evidence regarding the clinical efficacy of extended-release niacin and the DP1 antagonist laropiprant in the treatment of hypercholesterolemia and mixed dyslipidemias.
authors.affiliation: School of Pharmacy and Life Sciences, Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, Scotland, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Vosper
references.citation: Am J Cardiol. 2008 Mar 1;101(5):625-30
references.pmid: 18308010
references.citation: Am J Cardiol. 2006 Feb 15;97(4):477-9
references.pmid: 16461040
references.citation: Arterioscler Thromb. 1992 Feb;12(2):187-95
references.pmid: 1543692
references.citation: Nat Med. 2011 Jul 07;17(7):756
references.pmid: 21738133
references.citation: Am J Cardiovasc Drugs. 2008;8(2):69-81
references.pmid: 18422390
references.citation: Clin Liver Dis. 2003 May;7(2):415-33
references.pmid: 12879992
references.citation: Platelets. 2010;21(3):191-8
references.pmid: 20163197
references.citation: J Clin Invest. 2010 Aug;120(8):2910-9
references.pmid: 20664170
references.citation: Curr Med Res Opin. 2006 Feb;22(2):417-25
references.pmid: 16466614
references.citation: Int J Clin Pract. 2009 Jan;63(1):151-9
references.pmid: 19054161
references.citation: Physiol Rev. 2006 Apr;86(2):515-81
references.pmid: 16601268
references.citation: N Engl J Med. 2008 Apr 3;358(14):1431-43
references.pmid: 18376000
references.citation: Nat Med. 2001 Jan;7(1):41-7
references.pmid: 11135614
references.citation: J Hum Hypertens. 2000 Sep;14(9):567-72
references.pmid: 10980588
references.citation: Curr Opin Investig Drugs. 2004 Mar;5(3):271-5
references.pmid: 15083592
references.citation: Circulation. 2002 Aug 20;106(8):1024-8
references.pmid: 12186811
references.citation: J Investig Med. 2009 Aug;57(6):703-8
references.pmid: 19240648
references.citation: Circulation. 1973 Mar;47(3 Suppl):I1-50
references.pmid: 4570454
references.citation: Mol Pharmacol. 2005 Nov;68(5):1271-80
references.pmid: 16099840
references.citation: J Clin Lipidol. 2008 Apr;2(2):79-90
references.pmid: 21291724
references.citation: Arch Intern Med. 2004 Apr 12;164(7):697-705
references.pmid: 15078639
references.citation: J Clin Pharmacol. 2010 Nov;50(11):1273-9
references.pmid: 20107202
references.citation: Biochem Biophys Res Commun. 2003 Mar 28;303(1):364-9
references.pmid: 12646212
references.citation: Am J Ther. 2009 May-Jun;16(3):215-23
references.pmid: 19454860
references.citation: Aliment Pharmacol Ther. 2007 May 15;25(10):1135-51
references.pmid: 17451560
references.citation: J Pharmacol Exp Ther. 2008 Dec;327(3):665-72
references.pmid: 18784348
references.citation: Ther Clin Risk Manag. 2010 Apr 15;6:183-90
references.pmid: 20421916
references.citation: Curr Atheroscler Rep. 2003 Sep;5(5):418-22
references.pmid: 12911853
references.citation: Am J Cardiol. 2009 Jul 1;104(1):74-81
references.pmid: 19576324
references.citation: J Sex Med. 2008 Feb;5(2):344-56
references.pmid: 18047485
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20979-84
references.pmid: 18077391
references.citation: J Ren Nutr. 2005 Jan;15(1):87-93
references.pmid: 15648014
references.citation: Clin Ther. 2009 Jan;31(1):115-22
references.pmid: 19243712
references.citation: Am J Cardiovasc Drugs. 2009;9(2):109-15
references.pmid: 19331439
references.citation: J Invest Dermatol. 1992 May;98(5):812-5
references.pmid: 1373750
references.citation: Diabetes Care. 2009 Jan;32 Suppl 1:S13-61
references.pmid: 19118286
references.citation: Eur Heart J. 2010 Dec;31(23):2844-53
references.pmid: 20965889
references.citation: Circulation. 2004 Dec 7;110(23):3512-7
references.pmid: 15537681
references.citation: Trends Cardiovasc Med. 2004 Jan;14(1):8-12
references.pmid: 14720468
references.citation: Am J Cardiovasc Drugs. 2005;5(6):379-87
references.pmid: 16259526
references.citation: Am J Cardiol. 1998 Dec 17;82(12A):74U-81U;  discussion 85U-86U
references.pmid: 9915666
references.citation: Arch Intern Med. 2002 Jul 22;162(14):1568-76
references.pmid: 12123399
references.citation: Arterioscler Thromb Vasc Biol. 1998 May;18(5):794-802
references.pmid: 9598839
references.citation: JAMA. 1975 Jan 27;231(4):360-81
references.pmid: 1088963
references.citation: FEBS J. 2010 Mar;277(6):1410-9
references.pmid: 20136655
references.citation: Curr Opin Pharmacol. 2007 Feb;7(1):33-8
references.pmid: 17129762
references.citation: Age (Dordr). 2010 Sep;32(3):271-82
references.pmid: 20640551
references.citation: Am J Cardiol. 2003 Mar 15;91(6):667-72
references.pmid: 12633795
references.citation: J Allergy Clin Immunol. 2009 Nov;124(5):942-8.e1-9
references.pmid: 19748656
references.citation: J Clin Invest. 2010 Aug;120(8):2651-5
references.pmid: 20664168
references.citation: J Clin Invest. 2005 Dec;115(12):3634-40
references.pmid: 16322797
references.citation: Br J Pharmacol. 1998 Dec;125(7):1601-9
references.pmid: 9884090
references.citation: J Clin Pharmacol. 2009 Apr;49(4):416-22
references.pmid: 19246721
references.citation: Prev Cardiol. 2003 Fall;6(4):179-88
references.pmid: 14605511
references.citation: Drug Metab Dispos. 2007 Jul;35(7):1196-202
references.pmid: 17431030
references.citation: Nat Rev Drug Discov. 2007 Apr;6(4):313-25
references.pmid: 17396136
references.citation: Vasc Health Risk Manag. 2007;3(1):159-64
references.pmid: 17583186
references.citation: Arch Intern Med. 1999 May 24;159(10):1097-103
references.pmid: 10335687
references.citation: Exp Neurol. 2009 Oct;219(2):481-91
references.pmid: 19576888
references.citation: J Invest Dermatol. 2006 Dec;126(12):2637-46
references.pmid: 17008871
references.citation: Expert Opin Investig Drugs. 2010 Mar;19(3):437-49
references.pmid: 20141348
references.citation: J Clin Hypertens (Greenwich). 2009 Nov;11(11):685-9
references.pmid: 19878384
references.citation: Eur Heart J. 2007 Feb;28(4):398-406
references.pmid: 17277033
references.citation: Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81
references.pmid: 17299078
references.citation: Arthritis Res Ther. 2003;5(1):8-11
references.pmid: 12716442
references.citation: Am J Cardiol. 2008 May 15;101(10):1428-36
references.pmid: 18471454
references.citation: JAMA. 2006 Apr 5;295(13):1556-65
references.pmid: 16533939
references.citation: Int J Clin Pract. 2010 May;64(6):727-38
references.pmid: 20518948
references.citation: Cardiology. 2009;114(3):192-8
references.pmid: 19602880
references.citation: Stroke. 2006 Jul;37(7):1923-32
references.pmid: 16741184
references.citation: Br J Pharmacol. 2009 Sep;158(2):429-41
references.pmid: 19627285
references.citation: Int J Cardiol. 2007 May 2;117(3):373-80
references.pmid: 16860414
references.citation: Int J Clin Pract. 2009 Sep;63(9):1369-77
references.pmid: 19691622
references.citation: J Exp Med. 2007 Feb 19;204(2):357-67
references.pmid: 17283205
references.citation: Cardiovasc Res. 2009 Aug 1;83(3):586-94
references.pmid: 19423618
references.citation: Am J Cardiol. 1998 Mar 15;81(6):805-7
references.pmid: 9527102
references.citation: J Cardiovasc Pharmacol. 2007 Nov;50(5):470-9
references.pmid: 18030055
references.citation: Am Heart J. 2011 Mar;161(3):538-43
references.pmid: 21392609
references.citation: Br J Pharmacol. 2008 Mar;153 Suppl 1:S68-75
references.pmid: 18037924
references.citation: Circ Res. 1995 May;76(5):750-7
references.pmid: 7728991
references.citation: Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8
references.pmid: 19307115
references.citation: Biochem Pharmacol. 2004 Feb 1;67(3):411-9
references.pmid: 15037193
references.citation: Am J Med Sci. 2005 Feb;329(2):62-5
references.pmid: 15711421
references.citation: Biochem Pharmacol. 2006 Feb 28;71(5):646-56
references.pmid: 16386710
references.citation: J Biol Chem. 2003 Mar 14;278(11):9869-74
references.pmid: 12522134
references.citation: Am J Cardiovasc Drugs. 2009;9(2):69-79
references.pmid: 19331435
references.citation: Toxicol Lett. 2000 Mar 15;112-113:519-29
references.pmid: 10720775
references.citation: Metabolism. 2003 Jun;52(6):699-704
references.pmid: 12800094
references.citation: Vasc Health Risk Manag. 2009;5:901-8
references.pmid: 20016845
references.citation: Cardiovasc Ther. 2009 Winter;27(4):239-45
references.pmid: 19903187
references.citation: Am J Hypertens. 2003 Jan;16(1):67-71
references.pmid: 12517686
references.citation: Cardiovasc Ther. 2008 Summer;26(2):85-8
references.pmid: 18485130
references.citation: N Engl J Med. 2001 Nov 15;345(20):1444-51
references.pmid: 11794192
references.citation: Lancet. 2009 Jun 20;373(9681):2125-35
references.pmid: 19501900
references.citation: N Engl J Med. 2006 Feb 16;354(7):731-9
references.pmid: 16481640
references.citation: N Engl J Med. 2007 Jul 5;357(1):67-9
references.pmid: 17551162
references.citation: Clin Immunol. 2005 Feb;114(2):100-9
references.pmid: 15639643
references.citation: Biochem Biophys Res Commun. 2006 Jun 23;345(1):29-37
references.pmid: 16674924
references.citation: Atherosclerosis. 2007 Jun;192(2):253-8
references.pmid: 16945375
references.citation: Expert Opin Pharmacother. 2010 Jul;11(10):1715-26
references.pmid: 20518616
references.citation: Mol Cell. 2001 Jan;7(1):161-71
references.pmid: 11172721
references.citation: J Immunol. 2004 Mar 15;172(6):3822-9
references.pmid: 15004188
references.citation: Int J Clin Pract. 2008 Dec;62(12):1959-70
references.pmid: 19166443
references.citation: Curr Med Res Opin. 2006 Nov;22(11):2243-50
references.pmid: 17076985
references.citation: Am J Cardiol. 2005 Jan 15;95(2):254-7
references.pmid: 15642562
references.citation: J Pharmacol Exp Ther. 2008 Mar;324(3):883-93
references.pmid: 18165311
references.citation: JAMA. 2006 Oct 4;296(13):1653-6
references.pmid: 16968830
references.citation: Diabetologia. 2005 Sep;48(9):1726-35
references.pmid: 16025252
references.citation: Science. 2000 Mar 17;287(5460):2013-7
references.pmid: 10720327
references.citation: Am J Cardiol. 1998 Feb 26;81(4A):52B-59B
references.pmid: 9526815
references.citation: Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1259-65
references.pmid: 15155382