title: Single-neuron recordings from unanesthetized mouse dorsal cochlear nucleus.
abstract: Because of the availability of disease and genetic models, the mouse has become a valuable species for auditory neuroscience that will facilitate long-term goals of understanding neuronal mechanisms underlying the perception and processing of sounds. The goal of this study was to define the basic sound-evoked response properties of single neurons in the mouse dorsal cochlear nucleus (DCN). Neurons producing complex spikes were distinguished as cartwheel cells (CWCs), and other neurons were classified according to the response map scheme previously developed in DCN. Similar to observations in other rodent species, neurons of the mouse DCN exhibit relatively little sound-driven inhibition. As a result, type III was the most commonly observed response. Our findings are generally consistent with the model of DCN function that has been developed in the cat and the gerbil, suggesting that this in vivo mouse preparation will be a useful tool for future studies of auditory physiology.
authors.affiliation: Section on Synaptic Transmission, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Wei-Li Diana
authors.initials: WL
authors.lastname: Ma
authors.forename: Stephan D
authors.initials: SD
authors.lastname: Brenowitz
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D017626:Cochlear Nucleus / Q000166:cytology / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009474:Neurons / Q000166:cytology / Q000502:physiology*
references.citation: Naturwissenschaften. 1974 Nov;61(11):506-7
references.pmid: 4449570
references.citation: J Comp Neurol. 1983 Feb 1;213(4):426-47
references.pmid: 6300199
references.citation: J Neurophysiol. 1996 Apr;75(4):1411-31
references.pmid: 8727387
references.citation: Brain Res. 1980 Oct 27;200(1):23-37
references.pmid: 7417810
references.citation: J Physiol. 1972 Oct;226(1):263-87
references.pmid: 5083170
references.citation: J Comp Neurol. 1994 Oct 8;348(2):261-76
references.pmid: 7814691
references.citation: J Comp Neurol. 1979 Feb 1;183(3):519-38
references.pmid: 759446
references.citation: J Neurophysiol. 1999 Aug;82(2):1019-32
references.pmid: 10444694
references.citation: J Neurophysiol. 1993 May;69(5):1384-97
references.pmid: 8389821
references.citation: Hear Res. 1984 Oct;16(1):55-74
references.pmid: 6511673
references.citation: Hear Res. 1988 Nov;36(2-3):221-32
references.pmid: 3209494
references.citation: J Neurophysiol. 2002 May;87(5):2520-30
references.pmid: 11976388
references.citation: Eur J Neurosci. 2011 Feb;33(3):409-20
references.pmid: 21198989
references.citation: J Neurophysiol. 1988 Mar;59(3):1014-32
references.pmid: 3367194
references.citation: J Neurosci Methods. 1996 Apr;65(2):113-36
references.pmid: 8740589
references.citation: Genes Brain Behav. 2011 Feb;10(1):28-34
references.pmid: 20345895
references.citation: Hear Res. 2009 Nov;257(1-2):75-82
references.pmid: 19695320
references.citation: J Neurophysiol. 1976 Mar;39(2):282-300
references.pmid: 1255224
references.citation: J Neurosci. 1997 Sep 1;17(17):6798-806
references.pmid: 9254690
references.citation: Hear Res. 2000 Oct;148(1-2):74-87
references.pmid: 10978826
references.citation: Hear Res. 2004 Feb;188(1-2):29-41
references.pmid: 14759568
references.citation: J Neurophysiol. 1999 Aug;82(2):648-63
references.pmid: 10444663
references.citation: J Neurophysiol. 1996 Nov;76(5):3012-24
references.pmid: 8930251
references.citation: Hear Res. 1998 Jun;120(1-2):86-108
references.pmid: 9667434
references.citation: J Comp Neurol. 1993 Mar 1;329(1):36-52
references.pmid: 8454725
references.citation: J Neurophysiol. 2011 Aug;106(2):630-40
references.pmid: 21562186
references.citation: J Comp Neurol. 1974 Jun 1;155(3):301-29
references.pmid: 4836032
references.citation: J Comp Neurol. 1985 Dec 15;242(3):381-96
references.pmid: 2418077
references.citation: J Neurophysiol. 1995 Feb;73(2):743-65
references.pmid: 7760132
references.citation: J Neurophysiol. 2007 Aug;98(2):744-56
references.pmid: 17581852
references.citation: Trends Neurosci. 2004 Feb;27(2):104-10
references.pmid: 15102490
references.citation: J Comp Neurol. 1980 Jun 15;191(4):581-606
references.pmid: 6158528
references.citation: J Neurosci. 1999 Mar 15;19(6):2195-208
references.pmid: 10066273
references.citation: J Neurophysiol. 1997 May;77(5):2549-72
references.pmid: 9163376
references.citation: J Neurosci. 1998 May 15;18(10):3955-66
references.pmid: 9570822
references.citation: J Exp Biol. 1995 Sep;198(Pt 9):2007-23
references.pmid: 7595162
references.citation: Eur J Neurosci. 2005 Jun;21(12):3334-48
references.pmid: 16026471
references.citation: J Neurophysiol. 1997 Jul;78(1):229-47
references.pmid: 9242276
references.citation: Brain Res. 1981 Apr 6;210(1-2):342-9
references.pmid: 6164444
references.citation: J Comp Neurol. 1969 Aug;136(4):453-84
references.pmid: 5801446
references.citation: Exp Brain Res. 1973 Jun 29;17(4):402-27
references.pmid: 4725899
references.citation: Hear Res. 1992 Mar;58(2):132-52
references.pmid: 1568936
references.citation: J Acoust Soc Am. 1985 Mar;77(3):1091-101
references.pmid: 3980863
references.citation: J Neurophysiol. 2002 May;87(5):2505-19
references.pmid: 11976387
references.citation: J Neurophysiol. 1999 Dec;82(6):3434-57
references.pmid: 10601474
references.citation: J Basic Clin Physiol Pharmacol. 1996;7(3):199-220
references.pmid: 8910137
references.citation: Curr Opin Neurobiol. 2011 Aug;21(4):602-8
references.pmid: 21704507
references.citation: Hear Res. 2006 Jun-Jul;216-217:176-88
references.pmid: 16630701
references.citation: Behav Brain Res. 1998 Dec;97(1-2):1-12
references.pmid: 9867226
references.citation: J Neurophysiol. 2005 Jan;93(1):557-69
references.pmid: 15456804
references.citation: J Neurophysiol. 1993 May;69(5):1409-21
references.pmid: 8389823
references.citation: J Comp Neurol. 1991 Nov 15;313(3):457-68
references.pmid: 1770169
references.citation: J Comp Neurol. 1975 Jul 15;162(2):221-45
references.pmid: 1150920
references.citation: J Assoc Res Otolaryngol. 2011 Oct;12(5):633-45
references.pmid: 21717290
references.citation: PLoS One. 2010 Apr 01;5(4):e9705
references.pmid: 20368980
references.citation: J Neurophysiol. 1985 Oct;54(4):917-39
references.pmid: 4067627
references.citation: PLoS One. 2011 Mar 09;6(3):e17460
references.pmid: 21408007
references.citation: J Neurophysiol. 1980 Jul;44(1):76-96
references.pmid: 7420140
references.citation: J Neurophysiol. 2000 Feb;83(2):926-40
references.pmid: 10669505
references.citation: J Neurophysiol. 2007 Feb;97(2):1705-25
references.pmid: 17289937
references.citation: J Comp Neurol. 1984 Apr 1;224(2):155-72
references.pmid: 19180810
references.citation: J Assoc Res Otolaryngol. 2005 Sep;6(3):280-96
references.pmid: 16075189
references.citation: PLoS One. 2011 Mar 09;6(3):e17721
references.pmid: 21408017
references.citation: Biol Cybern. 2008 Jun;98(6):491-507
references.pmid: 18491162
references.citation: J Neurophysiol. 1995 Feb;73(2):550-61
references.pmid: 7760117
references.citation: J Comp Neurol. 1974 Jun 1;155(3):251-300
references.pmid: 4134212