title: [An inadequate intake of manganese may favour insulin resistance in girls].
abstract: OBJECTIVE
  to study the relationship between an adequate manganese (Mn) intake and glucose, insulin levels and insulin resistance among healthy children from Madrid (Spain).
  
  
  METHODS
  573 schoolchildren between 8 and 13 years old were studied. Energy and nutrients intake (especially Mn) was calculated with a "3-day diet record". Mn intake was compared to Adequate Intakes (AI) for this mineral. Weight and height were measured and body mass index (BMI) calculated. Fasting glucose and insulin were determined and the HOMA index was calculated to establish the presence of insulin resistance in children.
  
  
  RESULTS
  Girls with and inadequate intake (below the 100% of the AI value) had higher insulin and HOMA values than girls with adequate AI values (equal or higher to 100% of AI). Having in mind confounding factors (energy, carbohydrates and lipids intake, BMI and age), a significant positive correlation was found between the contribution of Mn intake to AI and HOMA levels in girls.
  
  
  CONCLUSIONS
  It seems important to ensure an adequate Mn intake in girls in order to prevent insulin resistance and diabetes type 2 in the future.
authors.affiliation: Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense de Madrid, and Instituto de Investigación Sanitaria IdiPAZ, Hospital Universitario La Paz, Madrid, Spain. elerodri@farm.ucm.es
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Rodríguez
authors.forename: L M
authors.initials: LM
authors.lastname: Bermejo
authors.forename: A M
authors.initials: AM
authors.lastname: López-Sobaler
authors.forename: R M
authors.initials: RM
authors.lastname: Ortega
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008345:Manganese / Q000172:deficiency*; D012737:Sex Factors; D013030:Spain
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008345:Manganese