title: [Changes of brain oxidative stress induced by nano-alumina in ICR mice].
abstract: OBJECTIVE
  To investigate the brain oxidative stress injury induced by nano-alumina particles in ICR mice.
  
  
  METHODS
  Sixty male ICR mice were randomly divided into 6 groups: control group, solvent control group, 100 mg/kg micro-alumina particles group, 3 groups exposed to nano-alumina particles at the doses of 50, 100 and 200 mg/kg. The mice were exposed by nasal drip for 30 days. Then levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-PX) in brain tissues of mice were detected.
  
  
  RESULTS
  There was no difference of SOD activity in mouse brain between control group [(17.32 +/- 6.23)U/gHb] and 50 mg/kg nano-alumina particles group [(17.89 +/- 1.82) U/gHb]. The SOD activity [(4.93 +/- 2.30)U/gHb] in 200 mg/kg nano-alumina particles group was significantly lower than that in control group (P < 0.05). The MDA levels in 3 nano-alumina particles groups were (0.76 +/- 0.13), (1.00 +/- 0.30) and (1.16 +/- 0.39)nmol/ml, respectively, which were significantly higher than that [( 0.24 +/- 0.09)nmol/ml] in control group (P < 0.05). The GSH levels in 3 nano-alumina particles groups were (0.72 +/- 0.08), (0.55 +/- 0.19) and (0.61 +/- 0.20)mg/gpro, respectively, which were significantly lower than that [(1.55 +/- 0.34)mg/gpro]] in control group (P < 0.05). The CAT activity in 50 and 100 mg/kg nano-alumina particles groups were (10.40 +/- 3.84) and (10.40 +/- 2.00)U/mgpro, respectively, which were significantly higher than that [(5.79 +/- 0.96) U/mgpro] in control group (P < 0.05). The CAT activity [(3.25 +/- 1.04)U/mgpro] in 200 mg/kg nano-alumina particles group was significantly lower than that in control group (P < 0.05 ).
  
  
  CONCLUSIONS
  Nano-alumina particles can induce the oxidative stress damage in brain tissues of mice.
authors.affiliation: Department of Occupational Health and Environmental Health, Shah xi Medical University, Taiyuan, Shanxi province 030001, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Ji
authors.forename: Qin-Li
authors.initials: QL
authors.lastname: Zhang
authors.forename: Ru
authors.initials: R
authors.lastname: Bai
authors.forename: Fu-Ping
authors.initials: FP
authors.lastname: Gao
authors.forename: Cui-Cui
authors.initials: CC
authors.lastname: Ge
authors.forename: Zhi-Wu
authors.initials: ZW
authors.lastname: Wang
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Chen
authors.forename: Ce
authors.initials: C
authors.lastname: Zhang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Niu
mesh_terms: D000537:Aluminum Oxide / Q000633:toxicity*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000633:toxicity*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000537:Aluminum Oxide