title: Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties.
abstract: Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.
authors.affiliation: Department of Chemistry, University of Pavia, Pavia, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Grandi
authors.forename: Valentina
authors.initials: V
authors.lastname: Cassinelli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bini
authors.forename: Enrica
authors.initials: E
authors.lastname: Saino
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Mustarelli
authors.forename: Carla Renata
authors.initials: CR
authors.lastname: Arciola
authors.forename: Marcello
authors.initials: M
authors.lastname: Imbriani
authors.forename: Livia
authors.initials: L
authors.lastname: Visai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018786:Bone Substitutes; D002516:Ceramics; D020099:Coated Materials, Biocompatible; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D053768:Metal Nanoparticles; D053761:Nanocomposites; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; C022107:Bioglass; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D006046:Gold