title: Pediatric intracranial aneurysms: new and enlarging aneurysms after index aneurysm treatment or observation.
abstract: OBJECTIVE
  Children with brain aneurysms may be at higher risk than adults to develop new or enlarging aneurysms in a relatively short time. We sought to identify comorbidities and angiographic features in children that predict new aneurysm formation or enlargement of untreated aneurysms.
  
  
  METHODS
  Retrospective analysis of the University of California-San Francisco Pediatric Aneurysm Cohort data base including medical records and imaging studies was performed.
  
  
  RESULTS
  Of 83 patients harboring 114 intracranial aneurysms not associated with brain arteriovenous malformations or intracranial arteriovenous fistulas, 9 (8.4%) developed new or enlarging brain aneurysms an average of 4.2 years after initial presentation. Comorbidities that may be related to aneurysm formation were significantly higher in patients who developed new aneurysms (89%) as opposed to patients who did not develop new or enlarging aneurysms (41%; RR, 9.5; 95% CI, 1.9%-48%; P = .0099). Patients with multiple aneurysms at initial presentation were more likely than patients with a single aneurysm at presentation to develop a new or enlarging aneurysm (RR, 6.2; 95% CI, 2.1%-185; P = .0058). Patients who initially presented with at least 1 fusiform aneurysm were more likely to develop a new or enlarging aneurysm than patients who did not present with a fusiform aneurysm (RR, 22; 95% CI, 3.6%-68%; P = .00050). Index aneurysm treatment with parent artery occlusion also was associated with higher risk of new aneurysm formation (RR, 4.2; 95% CI, 1.3%-13%; P = .024). New aneurysms did not necessarily arise near index aneurysms. The only fatality in the series was due to subarachnoid hemorrhage from a new posterior circulation aneurysm arising 20 months after index anterior circulation aneurysm treatment in an immunosuppressed patient.
  
  
  CONCLUSIONS
  Patients who presented with a fusiform aneurysm had a significantly greater incidence of developing a new aneurysm or enlargement of an index aneurysm than did those who presented with a saccular aneurysm. In our patient cohort, 8 of the 9 children who eventually developed new or enlarging brain aneurysms initially presented with fusiform aneurysm morphology. Other comorbidities or multiple aneurysms were also common in these patients at initial presentation.
authors.affiliation: Department of Radiology, University of California, San Francisco, CA, USA. steven.hetts@radiology.ucsf.edu
authors.forename: S W
authors.initials: SW
authors.lastname: Hetts
authors.forename: J D
authors.initials: JD
authors.lastname: English
authors.forename: C F
authors.initials: CF
authors.lastname: Dowd
authors.forename: R T
authors.initials: RT
authors.lastname: Higashida
authors.forename: J T
authors.initials: JT
authors.lastname: Scanlon
authors.forename: V V
authors.initials: VV
authors.lastname: Halbach
mesh_terms: D000293:Adolescent; D002140:California / Q000453:epidemiology; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000196:embryology* / Q000601:surgery*; D008297:Male; D011859:Radiography; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors
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