title: Sinonasal problems and reflux.
abstract: Extraesophageal reflux has been implicated in many disorders affecting the upper airway. This article reviews the recent literature regarding the relationship of refractory chronic rhinosinusitis with extraesophageal reflux. Recent studies have shown that patients with refractory chronic rhinosinusitis have an increased prevalence of extraesophageal reflux. An association may exist between gastroesophageal reflux and rhinosinusitis, especially in individuals with medically and surgically refractory disease. These studies have a poor level of evidence and data supporting causation are lacking. However, evaluation and treatment should be considered in patients with chronic rhinosinusitis, especially in those with refractory disease.
authors.affiliation: Department of Otolaryngology and Communication Sciences, Zablocki VA Medical Center, Medical College of Wisconsin, 5000 West National Avenue, Milwaukee, WI 53202, 53214, USA. tloehrl@mcw.edu
authors.forename: Todd A
authors.initials: TA
authors.lastname: Loehrl
mesh_terms: D002908:Chronic Disease; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012220:Rhinitis / Q000209:etiology*; D012852:Sinusitis / Q000209:etiology*
chemical_list: D054328:Proton Pump Inhibitors