title: [From image-guided radiotherapy to dose-guided radiotherapy].
abstract: OBJECTIVE
  In case of tumour displacement, image-guided radiotherapy (IGRT) based on the use of cone beam CT (tomographie conique) allows replacing the tumour under the accelerator by rigid registration. Anatomical deformations require however replanning, involving an estimation of the cumulative dose, session after session. This is the objective of this study.
  
  
  METHODS
  Two examples of arc-intensity modulated radiotherapy are presented: a case of prostate cancer (total dose=80 Gy) with tomographie conique (daily prostate registration) and one head and neck cancer (70 Gy). For the head and neck cancer, the patient had a weekly scanner allowing a dose distribution calculation. The cumulative dose was calculated per voxel on the planning CT after deformation of the dose distribution (with trilinear interpolation) following the transformation given by a non-rigid registration step (Demons registration method) from: either the tomographie conique (prostate), or the weekly CT. The cumulative dose was eventually compared with the planned dose.
  
  
  RESULTS
  In cases of prostate irradiation, the "cumulative" dose corresponded to the planned dose to the prostate. At the last week of irradiation, it was above the planned dose for the rectum and bladder. The volume of rectal wall receiving more than 50 Gy (V50) was 20% at the planning and 26% at the end of treatment, increasing the risk of rectal toxicity (NTCP) of 14%. For the bladder wall, V50 were 73% and 82%, respectively. In head and neck, the "cumulative" dose to the parotid exceeded the planned dose (mean dose increasing from 46 Gy to 54 Gy) from the 5th week of irradiation on, suggesting the need for replanning within the first 5 weeks of radiotherapy.
  
  
  CONCLUSIONS
  The deformable registration estimates the cumulative dose delivered in the different anatomical structures. Validation on digital and physical phantoms is however required before clinical evaluation.
authors.affiliation: Inserm, U642, 35000 Rennes, France.
authors.forename: G
authors.initials: G
authors.lastname: Cazoulat
authors.forename: M
authors.initials: M
authors.lastname: Lesaunier
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: P
authors.initials: P
authors.lastname: Haigron
authors.forename: O
authors.initials: O
authors.lastname: Acosta
authors.forename: G
authors.initials: G
authors.lastname: Louvel
authors.forename: C
authors.initials: C
authors.lastname: Lafond
authors.forename: E
authors.initials: E
authors.lastname: Chajon
authors.forename: J
authors.initials: J
authors.lastname: Leseur
authors.forename: R
authors.initials: R
authors.lastname: de Crevoisier
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*