title: Genetic moderation of contextual effects on negative arousal and parenting in African-American parents.
abstract: A three-stage context amplification model was tested with a sample of 345 African-American parent-child dyads. The model combined the conceptual structure of stress generation with recent findings regarding genetic susceptibility. Because the 7R + allele of the dopamine transporter (DRD4) has the potential to enhance contextual priming and arousal, this allele was examined as a potential moderator of each stage of the amplification process. Particular attention was given to the hypothesized influence of parental negative arousal on valence of parent-child interactions. The literature on genetic susceptibility led to the hypothesis that DRD4 would moderate each stage of the model in a "for better or for worse" manner. The model was partially supported. DRD4 moderated effects at all three stages of the model and, as hypothesized, DRD4 moderated contextual effects on negative arousal in a "for better or for worse" manner. Effects on parent-child interaction, however, were moderated in a "for worse" manner only. These results indicate that parenting interactions may amplify the effects of positive and negative contexts in a stress-generating manner, and that a susceptibility framework captures the way in which DRD4 moderates the impact of context on negative arousal.
authors.affiliation: Center for Contextual Genetics and Prevention Science, University of Georgia, Athens, GA, USA. srhbeach@uga.edu
authors.forename: Steven R H
authors.initials: SR
authors.lastname: Beach
authors.forename: Man Kit
authors.initials: MK
authors.lastname: Lei
authors.forename: Gene H
authors.initials: GH
authors.lastname: Brody
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Simons
authors.forename: Carolyn
authors.initials: C
authors.lastname: Cutrona
authors.forename: Robert A
authors.initials: RA
authors.lastname: Philibert
mesh_terms: D001741:Black or African American / Q000235:genetics / Q000523:psychology*; D000483:Alleles; D001143:Arousal / Q000235:genetics*; D005260:Female; D005838:Genotype; D005845:Georgia; D006801:Humans; D007407:Interviews as Topic; D007484:Iowa; D008137:Longitudinal Studies; D008297:Male; D010287:Parent-Child Relations; D016487:Parenting / Q000523:psychology*; D050638:Receptors, Dopamine D4 / Q000235:genetics* / Q000502:physiology; D012044:Regression Analysis; D013315:Stress, Psychological / Q000235:genetics / Q000523:psychology; D055815:Young Adult
chemical_list: C493599:DRD4 protein, human; D050638:Receptors, Dopamine D4
references.citation: J Fam Psychol. 2006 Jun;20(2):284-91
references.pmid: 16756404
references.citation: Hum Mol Genet. 1993 Jun;2(6):767-73
references.pmid: 8353495
references.citation: Mol Psychiatry. 2000 Jan;5(1):11-3
references.pmid: 10673763
references.citation: Pharmacogenomics J. 2003;3(6):343-8
references.pmid: 14581929
references.citation: Pers Relatsh. 2003 Sep;10(3):389-409
references.pmid: 17955056
references.citation: J Fam Psychol. 2011 Apr;25(2):174-83
references.pmid: 21480697
references.citation: Neurosci Biobehav Rev. 2000 Jan;24(1):21-5
references.pmid: 10654656
references.citation: Eur J Neurosci. 2002 Jan;15(1):158-64
references.pmid: 11860516
references.citation: Science. 1997 Aug 15;277(5328):918-24
references.pmid: 9252316
references.citation: Prev Sci. 2010 Dec;11(4):343-54
references.pmid: 20422290
references.citation: J Clin Psychol. 2006 Sep;62(9):1065-82
references.pmid: 16810666
references.citation: Mol Psychiatry. 2002;7(7):712-7
references.pmid: 12192615
references.citation: Psychol Bull. 2009 Nov;135(6):885-908
references.pmid: 19883141
references.citation: Acta Psychiatr Scand. 2005 Apr;111(4):291-9
references.pmid: 15740465
references.citation: Dev Psychopathol. 2011 Feb;23(1):7-28
references.pmid: 21262036
references.citation: J Health Soc Behav. 2007 Jun;48(2):149-63
references.pmid: 17583271
references.citation: Psychol Bull. 2000 Jan;126(1):78-108
references.pmid: 10668351
references.citation: J Pers Soc Psychol. 2000 Dec;79(6):1088-101
references.pmid: 11138756
references.citation: J Gerontol B Psychol Sci Soc Sci. 2005 Mar;60 Spec No 1:65-76
references.pmid: 15863711
references.citation: J Abnorm Child Psychol. 1988 Apr;16(2):197-206
references.pmid: 3385083
references.citation: Pers Individ Dif. 2008 Oct;45(6):503-508
references.pmid: 19088857
references.citation: J Neurosci. 2002 Nov 1;22(21):9185-93
references.pmid: 12417643
references.citation: Annu Rev Clin Psychol. 2007;3:107-35
references.pmid: 17716050
references.citation: J Pers Soc Psychol. 2004 Apr;86(4):517-29
references.pmid: 15053703
references.citation: Dev Psychobiol. 2006 Jul;48(5):406-9
references.pmid: 16770765
references.citation: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):309-14
references.pmid: 11756666
references.citation: J Appl Psychol. 2006 Jul;91(4):917-26
references.pmid: 16834514
references.citation: J Marital Fam Ther. 2012 Jan;38(1):201-19
references.pmid: 22283387
references.citation: J Fam Psychol. 2010 Oct;24(5):513-21
references.pmid: 20954761
references.citation: Behav Res Methods. 2009 Aug;41(3):924-36
references.pmid: 19587209
references.citation: Neurosci Lett. 2004 Aug 19;366(3):282-6
references.pmid: 15288435