title: Periodontal disease: a new factor associated with the presence of multiple complex coronary lesions.
abstract: OBJECTIVE
  Periodontal disease, including bone loss, is thought to be involved in coronary artery disease. Multiple complex coronary lesions relate to multifocal destabilization of coronary plaques. We investigated whether bone loss could be associated with the presence of multiple complex coronary lesions.
  
  
  METHODS
  This cross-sectional study included 150 patients with recent myocardial infarction (<1 month). Multiple complex coronary lesions were determined at coronary angiography. A panoramic dental X-ray including bone loss >50% was performed. Patients with no or simple complex lesions were compared to patients with multiple complex lesions.
  
  
  RESULTS
  Over 20% of patients had multiple complex coronary lesions. Patients with multiple complex lesion were less likely to be women and more likely to have multivessel disease or elevated C-reactive protein (CRP) than patients with no or single complex lesion. Bone loss >50% tended to be more frequent in patients with multiple complex lesions (p = 0.063). In multivariate analysis, multivessel disease, gender and CRP were associated with multiple complex lesion. Bone loss >50% increased the risk of multiple complex lesion.
  
  
  CONCLUSIONS
  Bone loss was associated with complex multiple coronary lesions, beyond systemic inflammation. These findings may bear important clinical implications for the prevention and treatment of coronary artery disease.
authors.affiliation: CHU, Odontologie, Dijon, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Romagna
authors.forename: Laurie
authors.initials: L
authors.lastname: Dufour
authors.forename: Odile
authors.initials: O
authors.lastname: Troisgros
authors.forename: Luc
authors.initials: L
authors.lastname: Lorgis
authors.forename: Carole
authors.initials: C
authors.lastname: Richard
authors.forename: Philippe
authors.initials: P
authors.lastname: Buffet
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulat
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Casillas
authors.forename: Gilles
authors.initials: G
authors.lastname: Rioufol
authors.forename: Claude
authors.initials: C
authors.lastname: Touzery
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.forename: Yves
authors.initials: Y
authors.lastname: Laurent
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000473:pathology; D003430:Cross-Sectional Studies; D004245:DMF Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology; D016017:Odds Ratio; D010512:Periodontal Index; D010518:Periodontitis / Q000150:complications* / Q000000981:diagnostic imaging; D019252:Radiography, Dental, Digital; D011862:Radiography, Panoramic; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D016388:Tooth Loss / Q000150:complications* / Q000473:pathology