title: Functional connectivity during language processing in acute cocaine withdrawal: a pilot study.
abstract: Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in acute cocaine withdrawal. Eight subjects in acute cocaine withdrawal were compared to controls for connectivity in language areas while performing a task involving categorization of words according to semantic and phonological relatedness. Acute withdrawal subjects had significantly less overall connectivity during semantic relatedness, and a trend towards less connectivity during phonological relatedness. Of potential future interest is whether this might serve as an imaging marker for treatment in patients.
authors.affiliation: Interdisciplinary Biomedical Science Graduate Program, The Ohio State University, Columbus, OH, USA.
authors.forename: Ananth
authors.initials: A
authors.lastname: Narayanan
authors.forename: Catherine A
authors.initials: CA
authors.lastname: White
authors.forename: Sanjida S
authors.initials: SS
authors.lastname: Saklayen
authors.forename: Amir
authors.initials: A
authors.lastname: Abduljalil
authors.forename: Petra
authors.initials: P
authors.lastname: Schmalbrock
authors.forename: Tom H
authors.initials: TH
authors.lastname: Pepper
authors.forename: Brad N
authors.initials: BN
authors.lastname: Lander
authors.forename: David Q
authors.initials: DQ
authors.lastname: Beversdorf
mesh_terms: D000208:Acute Disease; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D007802:Language; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology*; D010700:Phonetics; D010865:Pilot Projects; D012016:Reference Values; D012660:Semantics; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D014705:Verbal Behavior / Q000502:physiology; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
references.citation: J Neurosci. 2004 Oct 20;24(42):9228-31
references.pmid: 15496656
references.citation: Neurocase. 2008;14(4):378-83
references.pmid: 18766980
references.citation: Drug Alcohol Depend. 1995 Mar;37(3):247-53
references.pmid: 7796719
references.citation: Biol Psychiatry. 1994 Jul 1;36(1):5-20
references.pmid: 8080903
references.citation: Cognition. 1994 Apr-Jun;50(1-3):115-32
references.pmid: 8039356
references.citation: J Pharmacol Exp Ther. 2000 Dec;295(3):951-9
references.pmid: 11082428
references.citation: J Subst Abuse Treat. 2001 Apr;20(3):239-44
references.pmid: 11516594
references.citation: Neurocase. 2007 Oct;13(5):320-7
references.pmid: 18781429
references.citation: Psychiatry Res. 2010 Jan 30;181(1):15-23
references.pmid: 19959345
references.citation: Arch Gen Psychiatry. 1994 Sep;51(9):713-9
references.pmid: 8080348
references.citation: J Psychiatr Res. 2009 Aug;43(12):1018-24
references.pmid: 19135215
references.citation: Psychiatry Res. 1996 Mar 29;60(2-3):167-76
references.pmid: 8723307
references.citation: Psychiatry Res. 2007 Aug 15;155(3):189-201
references.pmid: 17582746
references.citation: Psychiatry Res. 2010 Mar 30;181(3):174-82
references.pmid: 20153142
references.citation: Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8734-7
references.pmid: 10900024
references.citation: Neuroreport. 1999 Sep 9;10(13):2763-7
references.pmid: 10511436
references.citation: Psychiatry Res. 2007 Apr 15;154(3):253-8
references.pmid: 17321725
references.citation: Int J Neurosci. 1991 Mar;57(1-2):73-9
references.pmid: 1938157
references.citation: Cereb Cortex. 2007 Apr;17(4):951-61
references.pmid: 16772313
references.citation: J Clin Exp Neuropsychol. 2007 Aug;29(6):610-6
references.pmid: 17691033
references.citation: Psychopharmacology (Berl). 1996 Dec;128(4):408-12
references.pmid: 8986011
references.citation: Drug Alcohol Depend. 2008 Jan 1;92(1-3):164-72
references.pmid: 17904770
references.citation: Drug Alcohol Depend. 2009 Oct 1;104(3):262-7
references.pmid: 19595517
references.citation: Neuroimage. 2005 Feb 1;24(3):810-21
references.pmid: 15652316
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1061-76
references.pmid: 9829288
references.citation: Psychopharmacology (Berl). 1999 Mar;142(4):343-51
references.pmid: 10229058
references.citation: Neuropsychopharmacology. 2010 Jun;35(7):1541-9
references.pmid: 20393459
references.citation: Brain Imaging Behav. 2010 Jun;4(2):189-97
references.pmid: 20502989
references.citation: Brain. 2006 Sep;129(Pt 9):2484-93
references.pmid: 16835247
references.citation: Brain Res Brain Res Rev. 2000 Aug;33(1):13-33
references.pmid: 10967352
references.citation: Brain. 2004 Aug;127(Pt 8):1811-21
references.pmid: 15215213
references.citation: Neuropsychopharmacology. 2005 Mar;30(3):610-7
references.pmid: 15637640
references.citation: Brain Res. 2007 Sep 26;1171:83-92
references.pmid: 17765877
references.citation: Neuroimage. 2006 Jul 1;31(3):1366-79
references.pmid: 16540350
references.citation: J Neurosci. 2003 Jan 1;23(1):12-6
references.pmid: 12514195
references.citation: PLoS One. 2010 Aug 17;5(8):e11933
references.pmid: 20808963
references.citation: J Autism Dev Disord. 2007 Jul;37(6):1040-8
references.pmid: 17191098
references.citation: Neuroimage. 2006 Apr 15;30(3):700-12
references.pmid: 16459104
references.citation: J Neurosci. 1998 Jul 15;18(14):5529-36
references.pmid: 9651233
references.citation: J Autism Dev Disord. 2000 Oct;30(5):497-502
references.pmid: 11098891
references.citation: Am J Addict. 2003 Jan-Feb;12(1):1-17
references.pmid: 12623736
references.citation: Cogn Behav Neurol. 2005 Jun;18(2):108-12
references.pmid: 15970730
references.citation: J Neurosci. 2009 May 6;29(18):6001-6
references.pmid: 19420266
references.citation: Psychopharmacology (Berl). 2006 May;185(4):479-86
references.pmid: 16550388
references.citation: Acta Psychiatr Scand. 1992 Oct;86(4):273-82
references.pmid: 1333719
references.citation: Brain Lang. 2008 Jan;104(1):42-50
references.pmid: 17418888
references.citation: Magn Reson Med. 2000 Jan;43(1):45-51
references.pmid: 10642730
references.citation: Am J Psychiatry. 1986 May;143(5):643-5
references.pmid: 3963255
references.citation: Am J Drug Alcohol Abuse. 1992;18(2):131-44
references.pmid: 1562011
references.citation: Neuropsychologia. 2003;41(3):293-303
references.pmid: 12457755
references.citation: Mol Psychiatry. 2004 Jun;9(6):557-69
references.pmid: 15098002
references.citation: J Cogn Neurosci. 2007 Mar;19(3):468-78
references.pmid: 17335395
references.citation: Pharmacol Biochem Behav. 2008 Jan;88(3):222-9
references.pmid: 17884154