title: Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and (125)I radiation therapy on pancreatic cancer.
abstract: Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combination of ING4 gene-therapy and radiotherapy against pancreatic cancer had been unknown. In this study, we demonstrated that either ING4 or (125)I radiotherapy treatment could induce Panc-1 pancreatic cancer cell growth suppression and apoptosis in vitro. Furthermore, both treatments inhibited tumor growth and angiogenesis of Panc-1 pancreatic cancer subcutaneously xenografted in vivo. Moreover, the combination therapy had a synergistic effect.
authors.affiliation: Cell and Molecular Biology Institute, College of Medicine, Soochow University, Suzhou, China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chenghai
authors.initials: C
authors.lastname: Su
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhai
authors.forename: Yue
authors.initials: Y
authors.lastname: Tian
authors.forename: Weihua
authors.initials: W
authors.lastname: Sheng
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Miao
authors.forename: Jicheng
authors.initials: J
authors.lastname: Yang
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D015316:Genetic Therapy; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000532:radiotherapy / Q000628:therapy*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011897:Random Allocation; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D018952:Antigens, CD34; D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; C483230:ING4 protein, human; D007457:Iodine Radioisotopes; D018809:Proliferating Cell Nuclear Antigen; D025521:Tumor Suppressor Proteins; D042461:Vascular Endothelial Growth Factor A