title: Current status and trends in the treatment of acute pulmonary thromboembolism.
abstract: Untreated acute pulmonary thromboembolism (APTE) is associated with high mortality, which is reduced by prompt treatment. Anticoagulation is fundamental in the treatment of APTE and should be initiated from suspicion. The efficacy and safety of novel anticoagulant drugs, such as oral anti-Xa and anti-IIa inhibitors, are topics in the treatment of APTE and are now under investigation. Thrombolytic therapy is a widely accepted treatment strategy for massive APTE, but its use for submassive APTE is controversial. Catheter intervention, percutaneous cardiopulmonary support and surgical embolectomy are also necessary and effective for some patients with APTE. A retrievable inferior vena cava filter is preferred for transient protection against APTE. Some studies have demonstrated the feasibility of outpatient treatment in patients with APTE after risk stratification.
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan. n-yamada@clin.medic.mie-u.ac.jp
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Mashio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
mesh_terms: D000208:Acute Disease; D000553:Ambulatory Care / Q000379:methods / Q000592:standards / Q000639:trends; D000925:Anticoagulants / Q000627:therapeutic use*; D006328:Cardiac Catheterization / Q000379:methods / Q000592:standards / Q000639:trends; D017128:Embolectomy / Q000379:methods / Q000592:standards / Q000639:trends; D065427:Factor Xa Inhibitors; D006801:Humans; D011516:Prothrombin / Q000037:antagonists & inhibitors; D011655:Pulmonary Embolism / Q000401:mortality / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods* / Q000592:standards / Q000639:trends*
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D011516:Prothrombin; C025337:Factor IIa