title: Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats.
abstract: OBJECTIVE
  To study the combinative effects of nanocerium and selenium in a murine model of diabetes.
  
  
  METHODS
  Cerium oxide (CeO(2)) nanoparticles (60 mg/kg per day) and sodium selenite (5 μmol/kg per day) alone or in combination, or the metal form of CeO(2) (60 mg/kg) were administered for 2 wk by intraperitoneal injection to streptozotocin-induced diabetic rats. At the end of treatment blood was collected, liver tissue dissected and then oxidative stress markers, extent of energy depletion and lipid profile were evaluated.
  
  
  RESULTS
  Antioxidant enzymes and high density lipoprotein decreased whereas oxidative stress, adenosine diphosphate/adenosine triphospahte levels, cholesterol, triglyceride and low density lipoprotein increased on induction of diabetes. All were improved by a combination of nanocerium and sodium selenite. There was a relative amelioration by CeO(2) nanoparticles or sodium selenite alone, but the metal form of CeO(2) showed no significant improvement.
  
  
  CONCLUSIONS
  The combination of nanocerium and sodium selenite is more effective than either alone in improving diabetes-induced oxidative stress.
authors.affiliation: Nazila Pourkhalili, Amir Nili-Ahmadabadi, Shokoufeh Hassani, Mohsen Pakzad, Maryam Baeeri, Azadeh Mohammadirad, Mohammad Abdollahi, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical sciences, Tehran 1417614411, Iran.
authors.forename: Nazila
authors.initials: N
authors.lastname: Pourkhalili
authors.forename: Asieh
authors.initials: A
authors.lastname: Hosseini
authors.forename: Amir
authors.initials: A
authors.lastname: Nili-Ahmadabadi
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Hassani
authors.forename: Mohsen
authors.initials: M
authors.lastname: Pakzad
authors.forename: Maryam
authors.initials: M
authors.lastname: Baeeri
authors.forename: Azadeh
authors.initials: A
authors.lastname: Mohammadirad
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
references.citation: J Trace Elem Med Biol. 2004;18(1):81-8
references.pmid: 15487768
references.citation: Arch Med Res. 2005 Jul-Aug;36(4):376-81
references.pmid: 15950078
references.citation: Toxicol Mech Methods. 2011 Mar;21(3):200-8
references.pmid: 21247366
references.citation: Pharmacogn Mag. 2010 Jan;6(21):34-41
references.pmid: 20548934
references.citation: Chem Commun (Camb). 2007 Mar 14;(10):1056-8
references.pmid: 17325804
references.citation: Biol Trace Elem Res. 2004 Summer;99(1-3):27-40
references.pmid: 15235139
references.citation: Evid Based Complement Alternat Med. 2010 Dec;7(4):465-70
references.pmid: 18955324
references.citation: Biomed Pharmacother. 2005 Aug;59(7):365-73
references.pmid: 16081237
references.citation: Hum Exp Toxicol. 2001 Jan;20(1):28-33
references.pmid: 11339622
references.citation: Exp Diabetes Res. 2011;2011:754132
references.pmid: 21437212
references.citation: Hum Exp Toxicol. 2010 Oct;29(10):851-64
references.pmid: 20194575
references.citation: Int J Nanomedicine. 2010 Aug 09;5:517-23
references.pmid: 20957114
references.citation: Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):295-9
references.pmid: 16285004