title: [The relationship between left ventricular diastolic function and arterial stiffness in diabetic coronary heart disease].
abstract: OBJECTIVE
  By measuring left ventricular diastolic function and arterial stiffness, this study aims to probe into the effect of diabetes mellitus (DM) on left ventricular diastolic function and arterial stiffness, and evaluate the correlation between left ventricular diastolic function and arterial stiffness.
  
  
  METHODS
  Seventy-six inpatients were enrolled. According to their coronary angiography, OGTT test results and past history of DM, patients were divided into controlled, CHD (coronary heart disease with no DM), and CHD + DM groups. Through invasive hemodynamic monitoring during left ventricular angiography, left ventricular end-diastolic pressure (LVEDP) and tau index were collected. Carotid-femoral pulse wave velocity (c-f PWV), reflected wave augmentation index (AIx@75) and other data reflecting the degree of arterial stiffness were collected bedside with non-invasive means. SPSS 18.0 was used for statistical analysis.
  
  
  RESULTS
  No significant difference was found between groups for LVEDP, tau index, and AIx@75. In terms of c-f PMV, The CHD + DM group (8.79 ± 1.59) cm/s differed significantly from the CHD group (7.43 ± 1.42) cm/s and the controlled group (6.83 ± 1.14) cm/s. No correlations were found between c-f PMV and LVEDP or tau index. A positive correlation was found between AIx@75 and tau index.
  
  
  CONCLUSIONS
  Compared with the controlled group and CHD patients with no DM, CHD + DM patients show worse arterial stiffness with no difference in ventricular diastolic function. There is a positive correlation between arterial stiffness and diastolic dysfunction.
authors.affiliation: Department of Cardiology, Friendship Hospital of the Capital Medical University, Beijing 100050, China.
authors.forename: Yan-kai
authors.initials: YK
authors.lastname: Lian
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Li
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Wu
authors.forename: Yong-liang
authors.initials: YL
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Shu-mei
authors.initials: SM
authors.lastname: Zhao
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D059289:Vascular Stiffness; D018487:Ventricular Dysfunction, Left / Q000209:etiology*; D016277:Ventricular Function, Left
chemical_list: D001786:Blood Glucose