title: Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease.
abstract: Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is characterized by the invariant cerebral accumulation of β-amyloid peptide. This event occurs early in the disease process. In humans, [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) is largely used to follow-up in vivo cerebral glucose utilization (CGU) and brain metabolism modifications associated with the Alzheimer's disease pathology. Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP(SweLon)/PS1(M146L), a mouse model of amyloidosis. We showed an age-dependent increase of glucose uptake in several brain regions of APP/PS1 mice but not in control animals and a higher [18F]-FDG uptake in the cortex and the hippocampus of 12-month-old APP/PS1 mice as compared with age-matched control mice. We then developed a method of 3-D microscopic autoradiography to evaluate glucose uptake at the level of amyloid plaques and showed an increased glucose uptake close to the plaques rather than in amyloid-free cerebral tissues. These data suggest a macroscopic and microscopic reorganization of glucose uptake in relation to cerebral amyloidosis.
authors.affiliation: Therapeutic Strategic Unit Aging, Alzheimer/Parkinson/Stroke, Chilly-Mazarin, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Poisnel
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Hérard
authors.forename: Nadine
authors.initials: N
authors.lastname: El Tannir El Tayara
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bourrin
authors.forename: Andreas
authors.initials: A
authors.lastname: Volk
authors.forename: Frank
authors.initials: F
authors.lastname: Kober
authors.forename: Benoit
authors.initials: B
authors.lastname: Delatour
authors.forename: Thierry
authors.initials: T
authors.lastname: Delzescaux
authors.forename: Thomas
authors.initials: T
authors.lastname: Debeir
authors.forename: Thomas
authors.initials: T
authors.lastname: Rooney
authors.forename: Jésus
authors.initials: J
authors.lastname: Benavides
authors.forename: Philippe
authors.initials: P
authors.lastname: Hantraye
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008840:Microfilament Proteins / Q000378:metabolism; D049268:Positron-Emission Tomography; D053764:Presenilin-1 / Q000235:genetics
chemical_list: C491049:Aif1 protein, mouse; D016564:Amyloid beta-Protein Precursor; D002135:Calcium-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D019788:Fluorodeoxyglucose F18; D005947:Glucose
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