title: Heat shock proteins in the human eye.
abstract: Heat shock proteins (Hsps) are believed to primarily protect and maintain cell viability under stressful conditions such as those occurring during thermal and oxidative challenges chiefly by refolding and stabilizing proteins. Hsps are found throughout the various tissues of the eye where they are thought to confer protection from disease states such as cataract, glaucoma, and cancer. This minireview summarizes the placement, properties, and roles of Hsps in the eye and aims to provide a better comprehension of their function and involvement in ocular disease pathogenesis.
authors.affiliation: Department of Ophthalmology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, 9100 Aalborg, Denmark.
authors.forename: Lærke
authors.initials: L
authors.lastname: Urbak
authors.forename: Henrik
authors.initials: H
authors.lastname: Vorum
references.citation: Oncogene. 2002 Aug 29;21(38):5844-51
references.pmid: 12185583
references.citation: J Biol Chem. 1993 Jan 25;268(3):1517-20
references.pmid: 8093612
references.citation: Invest Ophthalmol Vis Sci. 2006 Mar;47(3):786-93
references.pmid: 16505008
references.citation: Yan Ke Xue Bao. 2005 Sep;21(3):163-8
references.pmid: 17162855
references.citation: J Cell Biochem. 2002;84(2):278-84
references.pmid: 11787056
references.citation: Clin Exp Ophthalmol. 2009 Apr;37(3):299-307
references.pmid: 19472539
references.citation: Neurosci Lett. 1996 Mar 1;205(3):215-7
references.pmid: 8852596
references.citation: J Biol Chem. 2007 Jun 29;282(26):18953-9
references.pmid: 17452334
references.citation: Nat Rev Cancer. 2005 Oct;5(10):761-72
references.pmid: 16175177
references.citation: Arch Ophthalmol. 2000 Apr;118(4):511-8
references.pmid: 10766137
references.citation: Arch Int Physiol Biochim. 1969 Oct;77(4):717-30
references.pmid: 4188410
references.citation: Am J Public Health. 1995 Apr;85(4):546-50
references.pmid: 7702120
references.citation: J Korean Med Sci. 2004 Aug;19(4):591-7
references.pmid: 15308853
references.citation: FEBS Lett. 1985 Feb 11;181(1):1-6
references.pmid: 3972098
references.citation: Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2277-87
references.pmid: 9804136
references.citation: Acta Histochem. 2011 Jan;113(1):36-42
references.pmid: 19744702
references.citation: J Neurocytol. 2002 Feb;31(2):161-74
references.pmid: 12815237
references.citation: Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2082-91
references.pmid: 15914627
references.citation: Biochem Biophys Res Commun. 1995 Sep 25;214(3):1009-14
references.pmid: 7575503
references.citation: Jpn J Ophthalmol. 2002 Mar-Apr;46(2):123-9
references.pmid: 12062216
references.citation: Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1299-304
references.pmid: 12601062
references.citation: Trends Genet. 1999 May;15(5):191-6
references.pmid: 10322486
references.citation: Exp Eye Res. 1996 Nov;63(5):519-26
references.pmid: 8994355
references.citation: Ann Med. 1999 Aug;31(4):261-71
references.pmid: 10480757
references.citation: J Neurosci. 2000 May 15;20(10):3552-62
references.pmid: 10804196
references.citation: Biochem Biophys Res Commun. 2008 Jun 6;370(3):424-8
references.pmid: 18374659
references.citation: Korean J Ophthalmol. 2003 Jun;17(1):7-13
references.pmid: 12882502
references.citation: Br J Ophthalmol. 1977 Feb;61(2):126-32
references.pmid: 843509
references.citation: Proteomics. 2007 Feb;7(3):463-8
references.pmid: 17211826
references.citation: Eur J Biochem. 1994 Oct 1;225(1):1-19
references.pmid: 7925426
references.citation: Curr Eye Res. 1993 Mar;12(3):239-45
references.pmid: 8482112
references.citation: FEBS Lett. 1988 Aug 15;236(1):109-14
references.pmid: 3402607
references.citation: Korean J Ophthalmol. 2005 Jun;19(2):116-21
references.pmid: 15988927
references.citation: J Neurosci Res. 1994 May 1;38(1):19-31
references.pmid: 8057388
references.citation: Arch Ophthalmol. 2009 Feb;127(2):187-92
references.pmid: 19204237
references.citation: Fish Shellfish Immunol. 2010 Oct;29(4):600-7
references.pmid: 20541016
references.citation: Science. 2002 Mar 8;295(5561):1852-8
references.pmid: 11884745
references.citation: Annu Rev Genet. 1988;22:631-77
references.pmid: 2853609
references.citation: J Cell Biochem. 2010 May 15;110(2):311-20
references.pmid: 20336662
references.citation: Invest Ophthalmol Vis Sci. 1999 Feb;40(2):289-95
references.pmid: 9950586
references.citation: Prog Retin Eye Res. 1999 Jul;18(4):463-509
references.pmid: 10217480
references.citation: Am J Ophthalmol. 2004 Apr;137(4):760-2
references.pmid: 15059723
references.citation: Physiol Genomics. 2001 Oct 10;7(1):3-13
references.pmid: 11595787
references.citation: Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5403-11
references.pmid: 18552392
references.citation: Cornea. 2006 Sep;25(8):948-55
references.pmid: 17102673
references.citation: Curr Mol Med. 2009 Sep;9(7):887-92
references.pmid: 19860667
references.citation: Cancer Res. 2007 Jan 15;67(2):616-25
references.pmid: 17234771
references.citation: Aging Cell. 2007 Dec;6(6):807-15
references.pmid: 17973972
references.citation: Ophthalmology. 2001 Feb;108(2):296-302
references.pmid: 11158802
references.citation: Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2130-8
references.pmid: 11481282
references.citation: Graefes Arch Clin Exp Ophthalmol. 1984;221(4):149-52
references.pmid: 6706143
references.citation: J Cell Physiol. 2006 Feb;206(2):301-8
references.pmid: 16114012
references.citation: Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4129-35
references.pmid: 17724197
references.citation: Exp Eye Res. 1992 Mar;54(3):461-70
references.pmid: 1381680
references.citation: Histol Histopathol. 2008 Jul;23(7):827-31
references.pmid: 18437681
references.citation: Nat Cell Biol. 2000 Aug;2(8):469-75
references.pmid: 10934466
references.citation: FEBS Lett. 1995 May 29;365(2-3):133-6
references.pmid: 7781765
references.citation: Cell Death Differ. 2004 Apr;11(4):390-402
references.pmid: 14752510
references.citation: EMBO J. 1997 Jan 15;16(2):221-9
references.pmid: 9029143
references.citation: Ageing Res Rev. 2009 Apr;8(2):128-39
references.pmid: 19274853
references.citation: J Biomed Opt. 2004 Jan-Feb;9(1):187-92
references.pmid: 14715072
references.citation: J Hepatol. 1993 Aug;19(1):159-66
references.pmid: 7905491
references.citation: Nat Biotechnol. 2004 Nov;22(11):1399-408
references.pmid: 15529165
references.citation: Exp Eye Res. 1995 Jul;61(1):33-44
references.pmid: 7556468
references.citation: Protein Sci. 2010 May;19(5):1031-43
references.pmid: 20440841
references.citation: Trends Biochem Sci. 1996 Jan;21(1):22-6
references.pmid: 8848834
references.citation: Jpn J Ophthalmol. 1999 Mar-Apr;43(2):89-96
references.pmid: 10340789
references.citation: Invest Ophthalmol Vis Sci. 1995 Apr;36(5):774-86
references.pmid: 7706025
references.citation: Cell Stress Chaperones. 2005 Summer;10(2):86-103
references.pmid: 16038406
references.citation: Eur Arch Psychiatry Clin Neurosci. 1993;242(5):262-7
references.pmid: 8499494
references.citation: J Cell Biol. 1992 May;117(4):903-14
references.pmid: 1577863
references.citation: Annu Rev Cell Biol. 1993;9:601-34
references.pmid: 8280473
references.citation: Genes Dev. 1998 Dec 15;12(24):3788-96
references.pmid: 9869631
references.citation: Biotechnol Adv. 2008 Nov-Dec;26(6):591-609
references.pmid: 18789382
references.citation: Biochem Cell Biol. 2010 Apr;88(2):291-300
references.pmid: 20453930
references.citation: EMBO J. 1997 Feb 3;16(3):659-71
references.pmid: 9034347
references.citation: Invest Ophthalmol Vis Sci. 1993 Jan;34(1):10-22
references.pmid: 8425816
references.citation: Br J Ophthalmol. 2001 Aug;85(8):996-1000
references.pmid: 11466261
references.citation: Annu Rev Cell Dev Biol. 1995;11:441-69
references.pmid: 8689565
references.citation: Acta Ophthalmol Scand. 1998 Apr;76(2):149-53
references.pmid: 9591943
references.citation: Prog Drug Res. 2003;60:205-62
references.pmid: 12790344
references.citation: Invest Ophthalmol Vis Sci. 2003 Jul;44(7):3059-65
references.pmid: 12824252
references.citation: Mol Cell Biol. 1996 Sep;16(9):4691-9
references.pmid: 8756626
references.citation: Mol Vis. 1999 Aug 19;5:17
references.pmid: 10459042
references.citation: Science. 2003 May 16;300(5622):1142-5
references.pmid: 12750521
references.citation: In Vivo. 2008 May-Jun;22(3):311-5
references.pmid: 18610741
references.citation: Proteomics. 2005 Dec;5(18):4980-93
references.pmid: 16267820
references.citation: Invest Ophthalmol Vis Sci. 1997 Nov;38(12):2483-91
references.pmid: 9375566
references.citation: Mol Vis. 2007 Oct 30;13:2058-65
references.pmid: 18079679
references.citation: Curr Eye Res. 1995 Dec;14(12):1125-33
references.pmid: 8974842
references.citation: Invest Ophthalmol Vis Sci. 2010 Jan;51(1):12-20
references.pmid: 19643972
references.citation: Annu Rev Biochem. 1988;57:479-504
references.pmid: 3052280