title: Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
abstract: Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl(4))-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl(4) at 3 mL/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl(4) intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-α levels induced by CCl(4) intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury.
authors.affiliation: Department of General Surgery, Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China; E-Mails:  hzhhuodr7@sina.com  (H.Z.H.);  bwang5032@sina.com  (B.W.);  ykliangshyy1@sina.com  (Y.K.L.);  yybaodr28@sina.com  (Y.Y.B.).
authors.forename: Hai Zhong
authors.initials: HZ
authors.lastname: Huo
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Yong Kang
authors.initials: YK
authors.lastname: Liang
authors.forename: Yong Yang
authors.initials: YY
authors.lastname: Bao
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal; D006035:Glycyrrhiza / Q000737:chemistry* / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry*; D020011:Protective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D002251:Carbon Tetrachloride; D010088:Oxidoreductases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D006909:Hydroxyproline
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