title: Successful liver transplantation following veno-arterial extracorporeal membrane oxygenation in a child with fulminant Wilson disease and severe pulmonary hemorrhage: a case report.
abstract: Massive pulmonary hemorrhage and other serious cardiopulmonary diseases in patients with fulminant hepatitis result not only in graft failure but also mortality after LT. ECMO is used to treat children with cardiorespiratory failure refractory to conventional intensive care. We describe a five-yr-old girl with genetically confirmed fulminant Wilson disease and severe pulmonary hemorrhage who underwent successful primary LT following veno-arterial ECMO. To our knowledge, this is the first report of successful primary LT in a patient using veno-arterial ECMO. The present case demonstrates that ECMO, as a bridging modality to LT, may be necessary to manage both massive pulmonary hemorrhage and possible graft loss because of hypoxemia.
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seung Kook
authors.initials: SK
authors.lastname: Son
authors.forename: Seak Hee
authors.initials: SH
authors.lastname: Oh
authors.forename: Kyung Mo
authors.initials: KM
authors.lastname: Kim
authors.forename: Yeoun Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Won Kyoung
authors.initials: WK
authors.lastname: Jhang
authors.forename: Seong Jong
authors.initials: SJ
authors.lastname: Park
authors.forename: Hong Ju
authors.initials: HJ
authors.lastname: Shin
authors.forename: Jeong-Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Dae Yeon
authors.initials: DY
authors.lastname: Kim
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Park
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Sung-Gyu
authors.initials: SG
authors.lastname: Lee
mesh_terms: D002675:Child, Preschool; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006085:Graft Survival; D006470:Hemorrhage / Q000628:therapy; D006527:Hepatolenticular Degeneration / Q000628:therapy*; D006801:Humans; D000860:Hypoxia; D016031:Liver Transplantation / Q000379:methods*; D008168:Lung / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism; D013902:Radiography, Thoracic / Q000379:methods; D012131:Respiratory Insufficiency / Q000150:complications
chemical_list: D010100:Oxygen