title: Phenolic derivatives from Ruprechtia polystachya and their inhibitory activities on the glucose-6-phosphatase system.
abstract: Two new compounds, 5-methyl-2-(2-methylbutanoyl)phloroglucinol 1-O-(6-O-β-D-apiofuranosyl)-β-D-glucopyranoside (1) and trans-2,3-dihydrokaempferol 3-O-(4-O-sulfo)-α-L-arabinopyranoside (2), together with 14 known flavonoids, trans-dihydrokaempferol 3-O-α-L-arabinopyranoside (3), trans-taxifolin 3-O-α-L-arabinofuranoside (4), quercetin 3-O-α-L-rhamnopyranoside (5), quercetin 3'-O-α-L-arabinofuranoside (6), catechin 3-O-α-L-rhamnopyranoside (7), trans-taxifolin 3-O-α-L-arabinopyranoside (8), cis-dihydrokaempferol 3-O-α-L-arabinopyranoside (9), catechin (10), myricetin 3-O-α-L-rhamnopyranoside (11), quercetin 3-O-α-L-arabinopyranoside (12), quercetin 3-O-α-L-arabinofuranoside (13), quercetin 3-O-(3″-galloyl)-α-L-rhamnopyranoside (14), quercetin 3-O-(2″-galloyl)-α-L-rhamnopyranoside (15), and epicatechin 3-O-gallate (16), were isolated from the leaves of Ruprechtia polystachya Griseb. (Polygonaceae). Their structures were established on the basis of extensive 1D- and 2D-NMR experiments as well as MS analyses. All compounds, except 1, showed inhibition of the enzyme glucose-6-phosphatase in intact microsomes.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Pisa.
authors.forename: Maryan Bruzual
authors.initials: MB
authors.lastname: De Abreu
authors.forename: Abeer
authors.initials: A
authors.lastname: Temraz
authors.forename: Nicola
authors.initials: N
authors.lastname: Malafronte
authors.forename: Freddy
authors.initials: F
authors.lastname: Gonzalez-Mujica
authors.forename: Sandra
authors.initials: S
authors.lastname: Duque
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D019664:Polygonaceae / Q000737:chemistry*; D051381:Rats
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D010636:Phenols; D005952:Glucose-6-Phosphatase