title: [Systemic autoimmune diseases and depressive disorders].
abstract: BACKGROUND
  The incidence of depression accompanying medical pathologies is elevated and have prognostic importance.
  
  
  OBJECTIVE
  To determine the frequency of depression in patients with systemic autoimmune diseases (SAD), as well as to determine the frequency of pain, fatigue and sleep disorders in these patients and their relation with depression.
  
  
  METHODS
  We performed a descriptive, prospective study on 88 patients with AID. The CES-D depression questionnaire, FSS fatigue questionnaire and the Pittsburgh sleep quality index were administered.
  
  
  RESULTS
  69% (n=61) of patients were depressed. Pain was found in 97% (59/61) of depressed patients and in 62% (17/27) of non-depressed patients (P=.0006). Sleep disorders were found in 95% of depressed patients, whereas 60% of non-depressed patients presented them (P=.00008). Depression was associated with fatigue: 80% (49/61) for depressed and 44% for non-depressed (p=0,001) persons.
  
  
  CONCLUSIONS
  A very elevated prevalence of depression was found in SAD: 69%; constituting the most frequent comorbidity. Depression was significantly associated with pain, fatigue and sleep disorders.
authors.affiliation: Policlínica de Enfermedades Autoinmunes Sistémicas, Hospital Maciel, Montevideo, Uruguay. sylviaarias@montevideo.com.uy
authors.forename: Sylvia
authors.initials: S
authors.lastname: Arias
authors.forename: Victoria
authors.initials: V
authors.lastname: Fonsalía
authors.forename: Nicolás
authors.initials: N
authors.lastname: Asteggiante
authors.forename: Verónica
authors.initials: V
authors.lastname: Bartesaghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000523:psychology; D059350:Chronic Pain / Q000453:epidemiology / Q000209:etiology; D003863:Depression / Q000453:epidemiology / Q000209:etiology*; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology*; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires; D055815:Young Adult