title: Vaccines for malaria: how close are we?
abstract: Vaccines are the most powerful public health tools mankind has created, but malaria parasites are bigger, more complicated, and wilier than the viruses and bacteria that have been conquered or controlled with vaccines. Despite decades of research toward a vaccine for malaria, this goal has remained elusive. Nevertheless, recent advances justify optimism that a licensed malaria vaccine is within reach. A subunit recombinant protein vaccine that affords in the neighborhood of 50% protective efficacy against clinical malaria is in the late stages of clinical evaluation in Africa. Incremental improvements on this successful vaccine are possible and worth pursuing, but the best hope for a highly efficacious malaria vaccine that would improve prospects for malaria eradication may lie with the use of attenuated whole parasites and powerful immune-boosting adjuvants.
authors.affiliation: Malaria Research and Training Center, Faculty of Medicine, University of Bamako, Bamako, Mali, West Africa. mthera@icermali.org
authors.forename: Mahamadou A
authors.initials: MA
authors.lastname: Thera
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Plowe
mesh_terms: D000349:Africa; D006801:Humans; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000627:therapeutic use*; D011634:Public Health / Q000639:trends*
chemical_list: D017780:Malaria Vaccines
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13004-9
references.pmid: 19625622
references.citation: Vaccine. 2009 May 18;27(23):3090-8
references.pmid: 19428923
references.citation: Infect Immun. 2007 May;75(5):2283-90
references.pmid: 17307942
references.citation: J Infect Dis. 1998 Jun;177(6):1664-73
references.pmid: 9607847
references.citation: PLoS One. 2008 Jul 09;3(7):e2636
references.pmid: 18612426
references.citation: Insect Biochem Mol Biol. 2005 Jan;35(1):1-10
references.pmid: 15607650
references.citation: Science. 1984 Aug 10;225(4662):593-9
references.pmid: 6204383
references.citation: Lancet. 2004 Oct 16-22;364(9443):1411-20
references.pmid: 15488216
references.citation: PLoS One. 2010 Feb 04;5(2):e9041
references.pmid: 20140214
references.citation: PLoS Pathog. 2008 Sep 05;4(9):e1000147
references.pmid: 18773118
references.citation: PLoS Clin Trials. 2006 Nov 24;1(7):e34
references.pmid: 17124530
references.citation: Infect Immun. 2010 Feb;78(2):661-71
references.pmid: 19948834
references.citation: Infect Immun. 2004 Jan;72(1):154-8
references.pmid: 14688092
references.citation: Trends Parasitol. 2002 Mar;18(3):129-35
references.pmid: 11854091
references.citation: Mol Microbiol. 2004 Apr;52(1):159-68
references.pmid: 15049818
references.citation: N Engl J Med. 2011 Sep 15;365(11):1004-13
references.pmid: 21916638
references.citation: PLoS One. 2009;4(3):e4708
references.pmid: 19262754
references.citation: N Engl J Med. 2011 Sep 15;365(11):1062-4
references.pmid: 21916656
references.citation: Cell. 1995 Jul 14;82(1):101-10
references.pmid: 7606775
references.citation: PLoS One. 2009;4(4):e5254
references.pmid: 19390585
references.citation: Science. 1985 May 24;228(4702):996-9
references.pmid: 2988126
references.citation: Vaccine. 2010 Jul 12;28(31):5135-44
references.pmid: 19737527
references.citation: Parasite Immunol. 1992 May;14(3):321-37
references.pmid: 1625908
references.citation: Nature. 2002 Oct 3;419(6906):520-6
references.pmid: 12368866
references.citation: J Infect Dis. 1995 Jun;171(6):1576-85
references.pmid: 7769295
references.citation: PLoS Med. 2007 Mar;4(3):e93
references.pmid: 17355170
references.citation: Science. 2011 Oct 28;334(6055):475-80
references.pmid: 21903775
references.citation: Am J Med Sci. 1973 Sep;266(3):169-77
references.pmid: 4583408
references.citation: Lancet. 1993 Mar 20;341(8847):705-10
references.pmid: 8095622
references.citation: N Engl J Med. 1997 Jan 9;336(2):86-91
references.pmid: 8988885
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12488-93
references.pmid: 17636123
references.citation: Sci Transl Med. 2009 Oct 14;1(2):2ra5
references.pmid: 20165550
references.citation: J Exp Biol. 2003 Nov;206(Pt 21):3803-8
references.pmid: 14506215
references.citation: Vaccine. 2005 Mar 18;23(17-18):2243-50
references.pmid: 15755604
references.citation: J Infect Dis. 2009 Aug 1;200(3):329-36
references.pmid: 19569964
references.citation: Hum Vaccin. 2010 Jan;6(1):97-106
references.pmid: 19946222
references.citation: Nature. 2002 Oct 3;419(6906):498-511
references.pmid: 12368864
references.citation: Parasite Immunol. 2009 Sep;31(9):560-73
references.pmid: 19691559
references.citation: PLoS Med. 2011 Jan 25;8(1):e1000398
references.pmid: 21311586
references.citation: N Engl J Med. 2008 Dec 11;359(24):2521-32
references.pmid: 19064627
references.citation: Science. 1945 Aug 24;102(2643):202-4
references.pmid: 17787140
references.citation: Parasitology. 2007;134(Pt 13):1877-81
references.pmid: 17958923
references.citation: Mol Cell Biol. 1989 Jul;9(7):3151-4
references.pmid: 2701947
references.citation: Lancet. 1994 Oct 29;344(8931):1175-81
references.pmid: 7934537
references.citation: Vaccine. 2004 Dec 16;23(5):718-28
references.pmid: 15542195
references.citation: Infect Immun. 2001 May;69(5):3286-94
references.pmid: 11292751
references.citation: Vaccine. 1999 Oct 29;17 Suppl 3:S53-5
references.pmid: 10559535
references.citation: Hum Vaccin. 2010 Jan;6(1):78-83
references.pmid: 20061802
references.citation: Infect Immun. 2008 Jun;76(6):2660-70
references.pmid: 18378635
references.citation: PLoS One. 2010 Aug 19;5(8):e12294
references.pmid: 20808868
references.citation: PLoS One. 2010 Oct 21;5(10):e13490
references.pmid: 21042404
references.citation: Malar J. 2010 Jun 21;9:175
references.pmid: 20565971
references.citation: J Infect Dis. 2009 Dec 1;200(11):1646-9
references.pmid: 19877844
references.citation: Lancet. 2001 Dec 8;358(9297):1927-34
references.pmid: 11747915
references.citation: J Immunol. 2009 Dec 1;183(11):7268-77
references.pmid: 19915055
references.citation: J Exp Med. 1991 Nov 1;174(5):1203-8
references.pmid: 1940798
references.citation: J Immunol. 1984 Feb;132(2):909-13
references.pmid: 6317752
references.citation: Lancet. 1995 Aug 19;346(8973):462-7
references.pmid: 7637479
references.citation: Cell. 1995 Jul 14;82(1):89-100
references.pmid: 7606788
references.citation: Infect Immun. 2010 May;78(5):2248-56
references.pmid: 20194590
references.citation: Hum Vaccin. 2010 Jan;6(1):114-23
references.pmid: 19946204
references.citation: Bull World Health Organ. 2008 Feb;86(2):82
references.pmid: 18297155