title: Salicylic acid derivatives: synthesis, features and usage as therapeutic tools.
abstract: BACKGROUND
  In the field of medicinal chemistry, there is a growing interest in the use of small molecules. Although acetyl salicylic acid is well known for medical applications, little is known about other salicylic acid derivatives, and there is serious lack of data and information on the effects and biological evaluation that connect them.
  
  
  METHODS
  This review covers the synthesis and drug potencies of salicylic acid derivatives. After a brief overview of the information on salicylic acid and its features, a detailed review of salicylic acids as drugs and prodrugs, usage as cyclooxygenase inhibitors, properties in plants, synthesis and recent patents, is developed.
  
  
  CONCLUSIONS
  Salicylic acid research is still an important area and innovations continue to arise, which offer hope for new therapeutics in related fields. It is anticipated that this review will guide the direction of long-term drug/nutraceutical safety trials and stimulate ideas for future research.
authors.affiliation: Ondokuz Mayıs University, Agricultural Faculty, Department of Agricultural Biotechnology, Samsun, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ekinci
authors.forename: Murat
authors.initials: M
authors.lastname: Sentürk
authors.forename: Ömer İrfan
authors.initials: Öİ
authors.lastname: Küfrevioğlu
mesh_terms: D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D008297:Male; D010330:Patents as Topic; D010944:Plants / Q000187:drug effects; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D012459:Salicylates / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016861:Cyclooxygenase Inhibitors; D011355:Prodrugs; D012459:Salicylates