title: Toxicological assessment of noxious inhalants.
abstract: In the past centuries mankind has been exposed to various forms of air pollution not only at his occupational but also in his social environment. He mainly gets exposed with these pollutants through the respiratory organs and partially absorbs them into the body. Many of these airborne substances can be harmful for humans and some of them may account for tumorigenic effects.The following essay describes the main features of toxicological assessment of inhalative environmental and workplace xenobiotics. The essay also explains relevant characteristics and limit values of noxious compounds and gases and depicts modern testing methods. To this end, emphasis is given on methods characterizing the different stages of tumorigenic processes. Various test systems have been developed which can be used in vivo, ex vivo or in vitro. They are to a great part based on the evidence of changes in DNA or particular genes of cells. Among others they have highlighted the impact of interindividual variability on enzymatic activation of xenobiotics and on susceptibility of the host to tumor diseases.Unfortunately, for many inhalative environmental noxious agents no sufficient risk profiles have been developed. The completion of these profiles should be the goal of toxicological assessment in order to allow reasonable socioeconomic or individual-based risk reduction.
authors.affiliation: Klinik und Poliklinik für Hals-Nasen-Ohrenkranke der Universität Regensburg.
authors.forename: N H
authors.initials: NH
authors.lastname: Kleinsasser
authors.forename: A W
authors.initials: AW
authors.lastname: Sassen
authors.forename: B W
authors.initials: BW
authors.lastname: Wallner
authors.forename: R
authors.initials: R
authors.lastname: Staudenmaier
authors.forename: U A
authors.initials: UA
authors.lastname: Harréus
authors.forename: E
authors.initials: E
authors.lastname: Richter
references.citation: Proc Soc Exp Biol Med. 1999 Apr;220(4):244-8
references.pmid: 10202397
references.citation: Br J Cancer. 2000 Aug;83(3):412-7
references.pmid: 10917561
references.citation: Mutat Res. 2004 Oct 10;563(2):131-8
references.pmid: 15364279
references.citation: Am J Ind Med. 1999 Jul;36(1):101-7
references.pmid: 10361593
references.citation: Mutagenesis. 2001 Jan;16(1):25-30
references.pmid: 11139596
references.citation: Scand J Work Environ Health. 1998 Dec;24(6):486-94
references.pmid: 9988091
references.citation: IARC Sci Publ. 1992;(116):115-34
references.pmid: 1428078
references.citation: Mutat Res. 1993 Jul;288(1):47-63
references.pmid: 7686265
references.citation: Int Arch Occup Environ Health. 1995;67(5):305-10
references.pmid: 8543378
references.citation: Food Chem Toxicol. 1997 Jan;35(1):39-66
references.pmid: 9100814
references.citation: Toxicol Pathol. 2001 Sep-Oct;29(5):550-7
references.pmid: 11695572
references.citation: Cancer Lett. 1997 Jan 30;112(2):257-62
references.pmid: 9066737
references.citation: Laryngorhinootologie. 1999 Dec;78(12):679-84
references.pmid: 10666694
references.citation: Cancer Causes Control. 1992 Nov;3(6):555-68
references.pmid: 1420859
references.citation: Mutagenesis. 1995 Nov;10(6):555-9
references.pmid: 8596477
references.citation: Drug Metab Rev. 1999 May;31(2):467-87
references.pmid: 10335448
references.citation: Curr Opin Oncol. 2001 May;13(3):176-82
references.pmid: 11307061
references.citation: Toxicol Lett. 2002 Mar 10;128(1-3):229-41
references.pmid: 11869833
references.citation: Toxicol Lett. 1996 Aug;86(2-3):99-103
references.pmid: 8711784
references.citation: Environ Mol Mutagen. 2000;35(1):9-12
references.pmid: 10692222
references.citation: Int Arch Occup Environ Health. 2002 Oct;75 Suppl:S122-32
references.pmid: 12397423
references.citation: Mutat Res. 1992 Jan;281(1):39-45
references.pmid: 1371590
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1249-52
references.pmid: 11751441
references.citation: Eur Respir J. 1998 Apr;11(4):840-7
references.pmid: 9623686
references.citation: Mutat Res. 1976 Apr;40(2):139-66
references.pmid: 934177
references.citation: Gene. 1995 Jun 14;159(1):113-21
references.pmid: 7607565
references.citation: Mutat Res. 2000 Apr 13;467(1):21-30
references.pmid: 10771268
references.citation: Environ Health Perspect. 1997 Sep;105 Suppl 5:1329-36
references.pmid: 9400747
references.citation: HNO. 2002 Aug;50(8):743-52
references.pmid: 12243030
references.citation: Mutat Res. 2001 Apr 5;491(1-2):151-61
references.pmid: 11287308
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):49-62
references.pmid: 12376116
references.citation: Int J Cancer. 2004 Feb 10;108(4):483-7
references.pmid: 14696110
references.citation: HNO. 2001 May;49(5):378-81
references.pmid: 11405146
references.citation: Int J Cancer. 1997 Dec 10;73(6):828-30
references.pmid: 9399660
references.citation: N Z Med J. 2001 Mar 23;114(1128):114-20
references.pmid: 11346157
references.citation: Carcinogenesis. 1995 Apr;16(4):775-9
references.pmid: 7728954
references.citation: Mutat Res. 2004 Jul 11;561(1-2):63-73
references.pmid: 15238231
references.citation: Eur Arch Otorhinolaryngol. 2000;257(6):337-42
references.pmid: 10993555
references.citation: Laryngorhinootologie. 2001 Jan;80(1):23-6
references.pmid: 11272243
references.citation: Eur Arch Otorhinolaryngol. 1991;248(4):222-9
references.pmid: 1859655
references.citation: Cancer Res. 1993 Feb 15;53(4):733-6
references.pmid: 8381327
references.citation: Acta Otolaryngol Suppl. 1997;527:160-4
references.pmid: 9197510
references.citation: Mutat Res. 1985 Feb-Apr;147(1-2):29-36
references.pmid: 3974610
references.citation: Food Chem Toxicol. 2002 Aug;40(8):1223-8
references.pmid: 12067587
references.citation: Epidemiology. 1998 Jul;9(4):405-11
references.pmid: 9647904
references.citation: Laryngorhinootologie. 2001 Apr;80(4):187-90
references.pmid: 11383119
references.citation: Carcinogenesis. 1988 Sep;9(9):1687-93
references.pmid: 3409474
references.citation: Epidemiology. 2000 Sep;11(5):487-95
references.pmid: 10955399
references.citation: Mutat Res. 2002 Sep 30;506-507:21-8
references.pmid: 12351141
references.citation: Inhal Toxicol. 2003 May;15(6):619-38
references.pmid: 12692733
references.citation: J Nutr. 2001 Mar;131(3s):1041S-5S
references.pmid: 11238812
references.citation: Hum Genet. 1997 Mar;99(3):319-25
references.pmid: 9050916
references.citation: Cancer Causes Control. 2001 May;12(4):365-74
references.pmid: 11456233
references.citation: Arch Otorhinolaryngol. 1988;245(1):1-15
references.pmid: 2839136
references.citation: Mutat Res. 2002 Sep 30;506-507:65-77
references.pmid: 12351146
references.citation: Mutat Res. 1975 Dec;31(6):347-64
references.pmid: 768755
references.citation: Chem Res Toxicol. 1998 Jun;11(6):559-603
references.pmid: 9625726
references.citation: Am J Ind Med. 2000 Jun;37(6):581-9
references.pmid: 10797501
references.citation: Mutat Res. 2001 Oct 18;497(1-2):101-9
references.pmid: 11525912
references.citation: Strahlenther Onkol. 1997 Sep;173(9):462-8
references.pmid: 9340836
references.citation: Int J Cancer. 1991 Nov 11;49(5):758-63
references.pmid: 1937962
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):465-8
references.pmid: 9641488
references.citation: Food Chem Toxicol. 1989 Jan;27(1):53-63
references.pmid: 2649425
references.citation: Mutat Res. 1990 Nov-Dec;233(1-2):105-16
references.pmid: 2233792
references.citation: Carcinogenesis. 1989 Dec;10(12):2269-74
references.pmid: 2591016
references.citation: J Occup Environ Med. 1995 Jan;37(1):37-43
references.pmid: 7620941
references.citation: Toxicol Lett. 1995 Dec;82-83:627-32
references.pmid: 8597119
references.citation: Eur Respir J. 2001 Sep;18(3):598-611
references.pmid: 11589359
references.citation: HNO. 2003 Feb;51(2):134-9
references.pmid: 12589419
references.citation: Biochem Biophys Res Commun. 1984 Aug 30;123(1):291-8
references.pmid: 6477583
references.citation: Laryngorhinootologie. 2002 Jul;81(7):528-33
references.pmid: 12173065
references.citation: Drug Metab Rev. 2000 Aug-Nov;32(3-4):395-411
references.pmid: 11139137
references.citation: Allergy. 2003 Jul;58(7):572-9
references.pmid: 12823113
references.citation: Laryngorhinootologie. 1999 Apr;78(4):176-81
references.pmid: 10407822
references.citation: Carcinogenesis. 1998 Oct;19(10):1789-94
references.pmid: 9806160
references.citation: Eur Arch Otorhinolaryngol. 2005 Jul;262(7):561-6
references.pmid: 15619126
references.citation: Eur Respir J. 2001 Feb;17(2):214-9
references.pmid: 11334122
references.citation: Ann N Y Acad Sci. 1993 May 28;686:186-201; discussion 201-2
references.pmid: 8512247
references.citation: Int J Cancer. 2001 Mar 15;91(6):876-87
references.pmid: 11275995
references.citation: Toxicol Lett. 1998 Dec 28;102-103:173-83
references.pmid: 10022251
references.citation: Environ Mol Mutagen. 2000;35(3):206-21
references.pmid: 10737956
references.citation: Mutat Res. 2000 Jul;463(1):13-31
references.pmid: 10838207
references.citation: Chest. 2002 Sep;122(3):1086-90
references.pmid: 12226059
references.citation: Semin Oncol. 1996 Oct;23(5):536-45
references.pmid: 8893866
references.citation: Pharmacology. 2000 Sep;61(3):212-27
references.pmid: 10971208
references.citation: Toxicol Lett. 2003 Apr 11;140-141:183-93
references.pmid: 12676465
references.citation: J Agric Food Chem. 2002 Aug 14;50(17):4909-15
references.pmid: 12166981
references.citation: ORL J Otorhinolaryngol Relat Spec. 2001 May-Jun;63(3):141-7
references.pmid: 11359091
references.citation: Crit Rev Toxicol. 1996;26(2):199-211
references.pmid: 8688161