title: [Effects of balance-acupuncture stimulation of "back pain" and "hip pain" points on plasma beta-endorphin and ACTH contents in rats with lumbar disc herniation].
abstract: OBJECTIVE
  To observe the effect of balance acupuncture on the thermal pain threshold and plasma beta-endorphin (beta-EP) and adrenocorticotrophic hormone (ACTH) levels in lumbar disc herniation rats so as to research its mechanisms underlying improvement of lumbar disc protrusion.
  
  
  METHODS
  A total of 120 male rats were randomly divided into blank control (control) group, model group, sham-operation(sham)group, and acupuncture group (n=30) which were further divided into 7-days (d) and 14-d subgroups. Rats in the acupuncture group were treated with balance acupuncture of "Back Pain" point (the midpoint between two eyes) and "Hip Pain"point (the midpoint between the acromial process and the axillary furrow). Thermal pain threshold was detected by using radiant heat detector. Plasma beta-EP and ACTH levels were determined by radioimmunoassay.
  
  
  RESULTS
  Compared with the control group and pre-operation and sham group, the thermal pain reaction was increased significantly in the model group (P < 0.05). In comparison with the model group, the thermal pain reaction was decreased obviously from day 10 after acupuncture treatment in the acupuncture group (P < 0.05). Compared to the control group, plasma beta-EP contents on day 7 and 14 and ACTH level on day 14 in the model group were increased significantly (P < 0.05), while in comparison with the model group, plasma beta-EP contents on day 7 and 14 and ACTH level on day 14 in the acupuncture group were down-regulated markedly (P < 0.05). No significant difference were found between the control and sham groups in plasma beta-EP contents and ACTH levels on day 7 and 14 (P > 0.05).
  
  
  CONCLUSIONS
  Balance acupuncture treatment can lower plasma ACTH level in lumbar disc herniation rats, which may contribute to its effect in easing lumbar disc herniation pain in clinic practice.
authors.affiliation: School of Acu-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China. mawenzhu@139.com
authors.forename: Wen-zhu
authors.initials: WZ
authors.lastname: Ma
authors.forename: Yi-meng
authors.initials: YM
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Wen-yuan
authors.initials: WY
authors.lastname: Wang
mesh_terms: D015667:Acupuncture Analgesia; D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000097:blood / Q000628:therapy*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone