title: Genetics of canine olfaction and receptor diversity.
abstract: Olfaction is a particularly important sense in the dog. Humans selected for this capacity during the domestication process, and selection has continued to be employed to enhance this ability. In this review we first describe the different olfactory systems that exist and the different odorant receptors that are expressed in those systems. We then focus on the dog olfactory receptors by describing the olfactory receptor gene repertoire and its polymorphisms. Finally, we discuss the different uses of dog olfaction and the questions that still need to be studied.
authors.affiliation: Institut de Génétique et Développement de Rennes, UMR6061 CNRS Université de Rennes 1, Faculté de Médecine, 2 avenue Prof. Léon Bernard, CS34317, 35043 Rennes Cedex, France. pascale.quignon@univ-rennes1.fr
authors.forename: Pascale
authors.initials: P
authors.lastname: Quignon
authors.forename: Maud
authors.initials: M
authors.lastname: Rimbault
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Robin
authors.forename: Francis
authors.initials: F
authors.lastname: Galibert
mesh_terms: D000818:Animals; D004285:Dogs / Q000235:genetics* / Q000502:physiology; D009666:Nose / Q000033:anatomy & histology; D009812:Odorants; D009833:Olfactory Pathways / Q000502:physiology*; D044042:Receptors, Formyl Peptide / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology; D018035:Receptors, Odorant / Q000235:genetics*; D012903:Smell / Q000235:genetics*; D019147:Vomeronasal Organ / Q000502:physiology; D000095383:Trace Amine-Associated Receptors
chemical_list: D044042:Receptors, Formyl Peptide; D043562:Receptors, G-Protein-Coupled; D018035:Receptors, Odorant; D000095383:Trace Amine-Associated Receptors
references.citation: Genome Res. 2009 Mar;19(3):500-9
references.pmid: 19015322
references.citation: Nat Neurosci. 2007 Mar;10(3):348-54
references.pmid: 17310245
references.citation: Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14168-73
references.pmid: 15377787
references.citation: Genomics. 1999 Feb 15;56(1):98-110
references.pmid: 10036190
references.citation: Am J Hum Genet. 2008 Aug;83(2):228-42
references.pmid: 18674749
references.citation: J Neurosci. 2005 Feb 16;25(7):1806-15
references.pmid: 15716417
references.citation: Proc Natl Acad Sci U S A. 2005 May 10;102(19):6639-40
references.pmid: 15870190
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20421-6
references.pmid: 18077390
references.citation: Cell. 1999 Mar 5;96(5):713-23
references.pmid: 10089886
references.citation: Genome Res. 2007 Feb;17(2):166-74
references.pmid: 17210926
references.citation: Integr Cancer Ther. 2006 Mar;5(1):30-9
references.pmid: 16484712
references.citation: Ann N Y Acad Sci. 1998 Nov 30;855:182-93
references.pmid: 9929603
references.citation: Genomics. 1999 Oct 1;61(1):24-36
references.pmid: 10512677
references.citation: J Anat. 2003 Sep;203(3):329-38
references.pmid: 14529050
references.citation: Cell. 1997 Aug 22;90(4):775-84
references.pmid: 9288756
references.citation: Nature. 1987 Jan 29-Feb 4;325(6103):442-4
references.pmid: 3027574
references.citation: BMC Genomics. 2009 Dec 02;10:572
references.pmid: 19954510
references.citation: Nat Genet. 2000 Oct;26(2):221-4
references.pmid: 11017082
references.citation: J Hered. 2011 Sep-Oct;102 Suppl 1:S47-61
references.pmid: 21846747
references.citation: Hum Mol Genet. 2002 Jun 1;11(12):1381-90
references.pmid: 12023980
references.citation: Genome Biol. 2003;4(12):R80
references.pmid: 14659017
references.citation: J Comp Physiol A. 1998 Nov;183(5):635-50
references.pmid: 9839455
references.citation: Neuron. 1995 Dec;15(6):1383-92
references.pmid: 8845161
references.citation: Cell. 1996 Nov 15;87(4):675-86
references.pmid: 8929536
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10897-902
references.pmid: 8855279
references.citation: Science. 2003 Mar 28;299(5615):2054-8
references.pmid: 12663925
references.citation: Genomics. 2005 Mar;85(3):372-85
references.pmid: 15718104
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5767-72
references.pmid: 15790682
references.citation: Lancet. 1989 Apr 1;1(8640):734
references.pmid: 2564551
references.citation: Talanta. 2001 May 10;54(3):487-500
references.pmid: 18968273
references.citation: Nature. 1992 Jan 30;355(6359):453-5
references.pmid: 1370859
references.citation: Nat Rev Neurosci. 2003 Jul;4(7):551-62
references.pmid: 12838330
references.citation: Genome Res. 2005 Feb;15(2):231-40
references.pmid: 15653832
references.citation: J Biol Chem. 1998 Apr 17;273(16):9378-87
references.pmid: 9545261
references.citation: Biochem Biophys Res Commun. 1996 Apr 16;221(2):240-7
references.pmid: 8619840
references.citation: Genome Res. 2010 Jan;20(1):10-8
references.pmid: 19952141
references.citation: J Cell Biol. 1993 Dec;123(6 Pt 1):1441-52
references.pmid: 8253843
references.citation: Brain Res. 1986 Feb 26;366(1-2):329-32
references.pmid: 3697687
references.citation: Cell. 1991 Apr 5;65(1):175-87
references.pmid: 1840504
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9842-7
references.pmid: 19497865
references.citation: Nature. 2005 Dec 8;438(7069):803-19
references.pmid: 16341006
references.citation: J Hered. 2007;98(5):500-5
references.pmid: 17660504
references.citation: Lancet. 2001 Sep 15;358(9285):930
references.pmid: 11575380
references.citation: Nature. 2007 Sep 27;449(7161):468-72
references.pmid: 17873857
references.citation: BMC Genomics. 2009 Jan 14;10:21
references.pmid: 19144169
references.citation: Genome Res. 2001 May;11(5):685-702
references.pmid: 11337468
references.citation: Gene. 2005 Feb 14;346:13-21
references.pmid: 15716120
references.citation: J Hered. 2005;96(7):812-6
references.pmid: 16251519
references.citation: Nat Genet. 2003 Jun;34(2):143-4
references.pmid: 12730696
references.citation: Genome Biol. 2005;6(10):R83
references.pmid: 16207354
references.citation: PLoS Biol. 2007 Oct 30;5(11):e284
references.pmid: 17973576
references.citation: BMC Bioinformatics. 2007 Nov 22;8:460
references.pmid: 18034891
references.citation: J Comp Neurol. 2005 Sep 5;489(4):491-500
references.pmid: 16025460
references.citation: Cell. 1995 Oct 20;83(2):195-206
references.pmid: 7585937
references.citation: Nature. 2006 Aug 10;442(7103):645-50
references.pmid: 16878137
references.citation: Nature. 2009 May 28;459(7246):574-7
references.pmid: 19387439
references.citation: Genome Res. 2003 May;13(5):781-93
references.pmid: 12727898
references.citation: Genome Res. 2000 Dec;10(12):1968-78
references.pmid: 11116091
references.citation: Mol Biol Evol. 2007 Sep;24(9):2099-107
references.pmid: 17634392
references.citation: Genomics. 2004 May;83(5):802-11
references.pmid: 15081110
references.citation: BMC Genomics. 2006 May 22;7:121
references.pmid: 16716209
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2156-61
references.pmid: 14769939
references.citation: Trends Genet. 2007 May;23(5):212-5
references.pmid: 17382427
references.citation: Eur Urol. 2011 Feb;59(2):197-201
references.pmid: 20970246
references.citation: Mol Phylogenet Evol. 2005 May;35(2):470-82
references.pmid: 15804416
references.citation: Genome Res. 2009 Mar;19(3):491-9
references.pmid: 19129542
references.citation: Mol Biol Evol. 2003 Mar;20(3):307-14
references.pmid: 12644552
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2584-9
references.pmid: 14983052
references.citation: Gene. 2000 Dec 30;260(1-2):87-94
references.pmid: 11137294
references.citation: BMJ. 2004 Sep 25;329(7468):712
references.pmid: 15388612
references.citation: Hum Mol Genet. 2002 Mar 1;11(5):535-46
references.pmid: 11875048
references.citation: Nat Neurosci. 2002 Feb;5(2):124-33
references.pmid: 11802173
references.citation: PLoS Genet. 2008 Nov;4(11):e1000249
references.pmid: 18989455
references.citation: Genome Biol. 2003;4(11):R71
references.pmid: 14611657
references.citation: Genomics. 2005 Sep;86(3):306-15
references.pmid: 16024217
references.citation: Cell. 1997 Aug 22;90(4):763-73
references.pmid: 9288755
references.citation: Chem Senses. 2007 Jul;32(6):623-31
references.pmid: 17556730
references.citation: J Neurosci. 2004 Sep 22;24(38):8383-90
references.pmid: 15385621
references.citation: Cytokine Growth Factor Rev. 2006 Dec;17(6):501-19
references.pmid: 17084101
references.citation: Genomics. 2007 Apr;89(4):441-50
references.pmid: 17303377
references.citation: Neuron. 1997 Aug;19(2):371-9
references.pmid: 9292726
references.citation: Hum Mol Genet. 1994 Feb;3(2):229-35
references.pmid: 8004088
references.citation: Gene. 2005 Dec 5;362:70-84
references.pmid: 16229975
references.citation: J Neurosci Res. 2004 May 15;76(4):442-52
references.pmid: 15114616
references.citation: Genomics. 1997 Feb 1;39(3):239-46
references.pmid: 9119360
references.citation: PLoS One. 2010 Jun 15;5(6):e11133
references.pmid: 20559446
references.citation: Nucleic Acids Res. 1997 Dec 15;25(24):4876-82
references.pmid: 9396791
references.citation: Br J Pharmacol. 2006 Dec;149(8):967-78
references.pmid: 17088868
references.citation: Nat Neurosci. 2002 Feb;5(2):134-40
references.pmid: 11802169
references.citation: Nat Neurosci. 2001 Nov;4 Suppl:1192-8
references.pmid: 11687829
references.citation: J Cell Sci. 2004 Nov 15;117(Pt 24):5835-45
references.pmid: 15522887