title: A prospective study of the associations between treated diabetes and cancer outcomes.
abstract: OBJECTIVE
  To quantify the association of treated diabetes with cancer incidence and cancer mortality as well as cancer case fatality and all-cause mortality in adults who subsequently develop cancer and to calculate attributable fractions due to diabetes on various cancer outcomes.
  
  
  METHODS
  Prospective data on 599 diabetic and 17,681 nondiabetic adults from the CLUE II (Give Us a Clue to Cancer and Heart Disease) cohort in Washington County, Maryland, were analyzed. Diabetes was defined by self-reported use of diabetes medications at baseline. Cancer incidence was ascertained using county and state cancer registries. Mortality data were obtained from death certificates.
  
  
  RESULTS
  From 1989 to 2006, 116 diabetic and 2,365 nondiabetic adults developed cancer, corresponding to age-adjusted incidence of 13.25 and 10.58 per 1,000 person-years, respectively. Adjusting for age, sex, education, BMI, smoking, hypertension treatment, and high cholesterol treatment using Cox proportional hazards regression, diabetes was associated with a higher risk of incident cancer (hazard ratio 1.22 [95% CI 0.98-1.53]) and cancer mortality (1.36 [1.02-1.81]). In individuals who developed cancer, adults with diabetes had a higher risk of cancer case fatality (1.34 [1.002-1.79]) and all-cause mortality (1.61 [1.29-2.01]). For colorectal, breast, and prostate cancers, the attributable fractions resulting from diabetes were larger for cancer fatality and mortality than cancer incidence.
  
  
  CONCLUSIONS
  In this prospective cohort, diabetes appears to exert a greater influence downstream on the risk of mortality in people with cancer than on upstream risk of incident cancer.
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. hyeh1@jhmi.edu
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Yeh
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Platz
authors.forename: Nae-Yuh
authors.initials: NY
authors.lastname: Wang
authors.forename: Kala
authors.initials: K
authors.lastname: Visvanathan
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Brancati
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality; D048909:Diabetes Complications / Q000401:mortality*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D006331:Heart Diseases / Q000401:mortality; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008396:Maryland / Q000453:epidemiology; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000401:mortality; D012042:Registries; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents
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