title: DISC1: a schizophrenia gene with multiple personalities.
abstract: Two papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue of Neuron. These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field.
authors.affiliation: Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024-1759, USA. ewexler@ucla.edu
authors.forename: Eric M
authors.initials: EM
authors.lastname: Wexler
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Geschwind
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry / Q000235:genetics*; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D055495:Neurogenesis; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D012559:Schizophrenia / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D060509:Wnt3A Protein / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C412476:DISC1 protein, human; C528597:FEZ1 protein, human; D009419:Nerve Tissue Proteins; C555510:WNT3A protein, human; D060509:Wnt3A Protein; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3