title: T cell immunoglobulin and mucin-domain containing molecule 1 in peripheral blood mononuclear cells in Henoch Schonlein purpura.
abstract: The T cell immunoglobulin- and mucin domain-containing molecules (Tim) have been implicated in the pathogenesis of immune diseases. In this study, we used quantitative real time reverse transcription polymerase chain reaction to examine the Tim 1 mRNA expression in peripheral blood mononuclear cells from Henoch Schonlein purpura patients. The results showed that Tim1 mRNA expression was significantly higher in patients, which was closely correlated with serum TNFa, IL4 levels, IgA1 levels.
authors.affiliation: Department of Pediatrics, Anhui Medical University, Hefei, China. yuanliping3986@sina.com
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yuan
authors.forename: Lu
authors.initials: L
authors.lastname: Ling
authors.forename: Hu
authors.initials: H
authors.lastname: Bo
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D020869:Gene Expression Profiling; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood*; D007070:Immunoglobulin A / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000097:blood*; D016133:Polymerase Chain Reaction; D011991:Receptors, Virus / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C508598:IL4 protein, human; D007070:Immunoglobulin A; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4