title: Angiogenesis: the HETE is on.
abstract: In this issue of Blood, Singh and colleagues identify HMG-CoA reductase-dependent farnesylation of Rac-1 as critical for 15(S)-HETE-induced angiogenesis. These findings establish a novel link between eicosanoid and cholesterol metabolism with important biologic and therapeutic implications for angiogenesis.
authors.affiliation: Case Western Reserve University.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Nayak
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Jain