title: Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid.
abstract: A drug carrier based on glycyrrhetinic acid-modified sulfated chitosan (GA-SCTS) was synthesized. The glycyrrhetinic acid (GA) acted as both a hydrophobic group and a liver-targeting ligand. The GA-SCTS micelles displayed rapid and significant ability to target the liver in vivo. The IC(50) for doxorubicin (DOX)-loaded GA-SCTS micelles (DOX/SA-SCTS micelles) against HepG2 cells was 54.7 ng/mL, which was extremely lower than the amount of no-GA-modified DOX-loaded micelles. In addition, DOX/SA-SCTS micelles could target specifically the liver cancer cells. They had higher affinity for the liver cancer cells (HepG2 cells) than for the normal liver cells (Chang liver cells). There was nearly 2.18-fold improvement in uptake of the DOX/SA-SCTS micelles by HepG2 cells than that by Chang liver cells. These results indicate that GA-SCTS is not only an excellent carrier for drugs, but also a potential vehicle for liver-cancer targeting.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin, P. R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tian
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Chuang-Nian
authors.initials: CN
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006034:Glycyrrhetinic Acid / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000378:metabolism*; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry
chemical_list: D053769:Nanocapsules; D013431:Sulfates; D004317:Doxorubicin; D048271:Chitosan; D006034:Glycyrrhetinic Acid