title: Lupus nephritis: current update.
abstract: Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how the disease is currently diagnosed and treated.
authors.affiliation: Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Ramesh.saxena@utsouthwestern.edu
authors.forename: Ramesh
authors.initials: R
authors.lastname: Saxena
authors.forename: Tina
authors.initials: T
authors.lastname: Mahajan
authors.forename: Chandra
authors.initials: C
authors.lastname: Mohan
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D008181:Lupus Nephritis / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*
chemical_list: D018836:Inflammation Mediators; D003520:Cyclophosphamide
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