title: Systematic review: generating evidence-based guidelines on the concurrent use of dietary antioxidants and chemotherapy or radiotherapy.
abstract: The risk-benefit ratio for concurrent use of dietary antioxidants with chemotherapy or radiation therapy is a controversial topic. In this review, the medical literature on concurrent antioxidant use with chemotherapy or radiotherapy was assessed and further steps for generating evidence-based guidelines are suggested. The clinical cancer research community should cooperate and focus new studies on the use of a specific combination of antioxidant and chemotherapy or radiotherapy, and determine optimal doses for a specific cancer setting. Mechanistic studies on the interaction between antioxidants and conventional cancer therapy could lead to novel biomarkers for assessing dose adequacy.
authors.affiliation: Preferred Staffing Group, Inc., Washington, District of Columbia, USA.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakayama
authors.forename: Karen P
authors.initials: KP
authors.lastname: Alladin
authors.forename: Obianuju
authors.initials: O
authors.lastname: Igbokwe
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: White
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage*; D055317:Evidence-Based Practice; D005978:Glutathione / Q000008:administration & dosage; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D017410:Practice Guidelines as Topic; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D005978:Glutathione; D000111:Acetylcysteine
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