title: Lack of an association between -308G>A polymorphism of the TNF-α gene and liver cirrhosis risk based on a meta-analysis.
abstract: TNF-α is a potential proinflammatory cytokine that plays an  important role in the pathogenesis of liver cirrhosis. We investigated a  possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by  conducting a meta-analysis. Publications addressing the association between  TNF-α -308G>A and liver cirrhosis risk were  selected from the Pubmed and Embase databases. Data were extracted from the  studies by two independent reviewers; odds ratio (OR) with a 95% confidence  interval (CI) was calculated from these data. The meta-analysis was performed  by Review Manager Version 5.0.24 and STATA Version 9.2. Eleven studies were  retrieved, reporting a total of 1796 liver cirrhosis cases and 2113 healthy controls.  A meta-analysis of these 11 studies identified no significant association  between TNF-α -308G>A polymorphism and liver  cirrhosis risk in all comparisons of G vs A allele; GG vs GA +  AA; GG + GA vs AA; GG vs AA; GG vs GA (OR = 1.14, 95%CI =  0.85-1.55, P = 0.38; OR = 1.24, 95%CI = 0.87- 1.77, P = 0.24; OR = 0.90, 95%CI  = 0.62-1.30, P = 0.57; OR = 1.03, 95%CI = 0.56-1.89, P = 0.92; OR = 1.30, 95%CI  = 0.90-1.88, P = 0.17; respectively). In conclusion, we found no association  between TNF-α -308G>A polymorphism and liver  cirrhosis risk, both in Caucasian and Asian populations.
authors.affiliation: Department of Emergency, The Fourth Affiliated Hospital of China Medical University, Shenyang, PR China.
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: S W
authors.initials: SW
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D039781:PubMed; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha