title: Indatraline: synthesis and effect on the motor activity of Wistar rats.
abstract: A new approach for the synthesis of indatraline was developed using as the key step an iodine(III)-mediated ring contraction of a 1,2-dihydronaphthalene derivative. Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. On the other hand, no significant differences in motor activity were observed using indanamide. The results suggest that indatraline has a long lasting effect on motor activity and add evidence in favor of the potential use of that compound as a substitute in cocaine addiction.
authors.affiliation: Department of Experimental Psychology, Institute of Psychology, University of São Paulo, USP, São Paulo, SP CEP 05508-030, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Kameyama
authors.forename: Fernanda A
authors.initials: FA
authors.lastname: Siqueira
authors.forename: Miriam
authors.initials: M
authors.lastname: Garcia-Mijares
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Silva
authors.forename: Maria T A
authors.initials: MT
authors.lastname: Silva
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D019970:Cocaine-Related Disorders / Q000188:drug therapy; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007455:Iodine / Q000737:chemistry; D008297:Male; D008744:Methylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D009281:Naphthalenes / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007189:Indans; D008744:Methylamines; D009281:Naphthalenes; C086079:1,2-dihydronaphthalene; C418119:indatraline; D007455:Iodine
references.citation: J Org Chem. 2009 Mar 20;74(6):2561-6
references.pmid: 19231874
references.citation: Eur J Pharmacol. 1997 Oct 8;336(2-3):123-6
references.pmid: 9384223
references.citation: Pharmacol Biochem Behav. 2009 Feb;91(4):621-8
references.pmid: 18976683
references.citation: Angew Chem Int Ed Engl. 2011 Feb 11;50(7):1524-52
references.pmid: 21271626
references.citation: Nat Prod Rep. 2011 Oct;28(10):1722-54
references.pmid: 21829843
references.citation: Science. 1978 Oct 13;202(4364):227-8
references.pmid: 694530
references.citation: J Pharmacol Exp Ther. 2006 Jun;317(3):1088-96
references.pmid: 16478825
references.citation: J Med Chem. 2000 Dec 14;43(25):4868-76
references.pmid: 11123996
references.citation: Org Lett. 2007 Apr 12;9(8):1433-6
references.pmid: 17371034
references.citation: Trends Neurosci. 1991 Jul;14(7):299-302
references.pmid: 1719677
references.citation: J Org Chem. 2011 Feb 4;76(3):857-69
references.pmid: 21241065
references.citation: J Neurochem. 1985 May;44(5):1615-22
references.pmid: 2580950
references.citation: Chem Rev. 2008 Dec;108(12):5299-358
references.pmid: 18986207
references.citation: Neuropsychopharmacology. 2010 Dec;35(13):2624-37
references.pmid: 20881947
references.citation: Psychopharmacology (Berl). 2002 Mar;160(3):263-70
references.pmid: 11889495
references.citation: Addiction. 2002 Aug;97(8):931-49
references.pmid: 12144591
references.citation: Org Lett. 2005 Jul 7;7(14):2933-6
references.pmid: 15987173
references.citation: Br J Addict. 1991 Dec;86(12):1601-6
references.pmid: 1786493
references.citation: Neurosci Biobehav Rev. 2004 Jan;27(8):827-39
references.pmid: 15019432
references.citation: J Pharmacol Exp Ther. 1995 Apr;273(1):7-15
references.pmid: 7714815
references.citation: J Org Chem. 2010 May 7;75(9):2877-82
references.pmid: 20377233
references.citation: J Med Chem. 1985 Dec;28(12):1817-28
references.pmid: 2999402
references.citation: J Med Chem. 2000 Dec 28;43(26):4981-92
references.pmid: 11150168
references.citation: Org Biomol Chem. 2007 Mar 7;5(5):767-71
references.pmid: 17315062
references.citation: Psychopharmacology (Berl). 1999 Aug;145(4):370-7
references.pmid: 10460313
references.citation: J Org Chem. 2003 Feb 7;68(3):1158-60
references.pmid: 12558451
references.citation: Molecules. 2006 Jun 20;11(6):421-34
references.pmid: 17962775
references.citation: Org Lett. 2008 Dec 4;10(23):5417-20
references.pmid: 18973334
references.citation: Angew Chem Int Ed Engl. 2004 Jun 21;43(25):3224-8
references.pmid: 15213946
references.citation: Cochrane Database Syst Rev. 2010 Feb 17;(2):CD007380
references.pmid: 20166094
references.citation: Psychopharmacology (Berl). 1992;107(2-3):186-94
references.pmid: 1377395
references.citation: Psychol Rev. 1987 Oct;94(4):469-92
references.pmid: 3317472
references.citation: J Pharmacol Exp Ther. 1999 Oct;291(1):60-9
references.pmid: 10490887