title: Tandem one-pot synthesis of polysubstituted pyridines using the Blaise reaction intermediate and 1,3-enynes.
abstract: A tandem one-pot method for the construction of a pyridine moiety with selective control of substitution patterns has been developed through the sequential reactions of nitrile with a Reformatsky reagent and 1,3-enyne involving regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, followed by isomerization, cyclization, and an aromatization cascade.
authors.affiliation: Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Chun
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Ko
authors.forename: Sang-gi
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D009570:Nitriles; D011725:Pyridines