title: Second- and third-trimester termination of pregnancy in women with uterine scar - a retrospective analysis of 111 gemeprost-induced terminations of pregnancy after previous cesarean delivery.
abstract: BACKGROUND
  This study was conducted to evaluate and analyze the efficacy and safety of using gemeprost for second- and third-trimester termination of pregnancy (TOP) in women with uterine scar due to previous cesarean section.
  
  
  METHODS
  Retrospective analysis of 111 medical TOPs for fetal anomaly or death at 14 to 34 weeks of gestation in women with a history of cesarean section was performed at a German tertiary care center from 2005 to 2009. Abortion was induced via intravaginal application of the prostaglandin analogue gemeprost (1 mg) every 6 h.
  
  
  RESULTS
  One hundred eleven women with one (89.2%) or two (10.8%) previous cesarean sections underwent medical TOP with gemeprost. The median induction-to-expulsion interval was 18 h 24 min (range, 2 h 20 min-168 h 28 min), and in 34 (30.6%) cases, the induction interval was longer than 24 h. The overall incidence of severe complications was 9/111 (8.1%), including one case of silent uterine rupture (with the need for blood transfusion), four cases of atonic and three secondary hemorrhages and one case of peritonitis due to uterine perforation during curettage. Failure of induction (induction-to-expulsion >48 h) occurred in 11 cases (9.9%).
  
  
  CONCLUSIONS
  Gemeprost-induced TOP in the second and third trimester in women with uterine scar due to previous cesarean section is effective and has a low complication rate.
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany. Christian.Domroese@ukb.uni-bonn.de
authors.forename: Christian M
authors.initials: CM
authors.lastname: Domröse
authors.forename: Annegret
authors.initials: A
authors.lastname: Geipel
authors.forename: Christoph
authors.initials: C
authors.lastname: Berg
authors.forename: Henning
authors.initials: H
authors.lastname: Lorenzen
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gembruch
authors.forename: Arne
authors.initials: A
authors.lastname: Willruth
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D002585:Cesarean Section / Q000009:adverse effects*; D002921:Cicatrix / Q000150:complications*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D014591:Uterine Diseases / Q000150:complications
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; C021182:gemeprost; D000527:Alprostadil