title: Peptidoglycan recognition proteins: modulators of the microbiome and inflammation.
abstract: All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.
authors.affiliation: Institut de Biologie du Développement de Marseille-Luminy, UMR6216 CNRS et Aix-Marseille Universites, Parc Scientifique de Luminy, Marseille, France. julien.royet@univmed.fr
authors.forename: Julien
authors.initials: J
authors.lastname: Royet
authors.forename: Dipika
authors.initials: D
authors.lastname: Gupta
authors.forename: Roman
authors.initials: R
authors.lastname: Dziarski
mesh_terms: D000825:Animal Structures / Q000382:microbiology; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D017124:Conserved Sequence; D004625:Embryo, Nonmammalian / Q000276:immunology / Q000382:microbiology; D056890:Eukaryota / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D007448:Invertebrates / Q000276:immunology / Q000382:microbiology; D054892:Metagenome / Q000276:immunology*; D008954:Models, Biological; D008958:Models, Molecular; D010457:Peptidoglycan / Q000276:immunology* / Q000378:metabolism; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013559:Symbiosis / Q000276:immunology*; D014714:Vertebrates / Q000276:immunology / Q000382:microbiology
chemical_list: D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D010457:Peptidoglycan; C118897:peptidoglycan recognition protein
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