title: Pathogenic role of effector cells and immunoglobulins in cationic bovine serum albumin-induced membranous nephropathy.
abstract: Membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis. The roles of effector cells and immunoglobulins (Igs) in the mediation of glomerular injury in MN have not been fully elucidated. MN was induced by cationic bovine serum albumin (cBSA), and passive disease was induced by transferring effector cells or serum into severe combined immunodeficient (SCID) mice. MN could not be induced in SCID mice. Transfer of serum from MN mice, but not from normal control mice, to SCID mice induced granular immune complex deposits and pathologic proteinuria. Increased immunofluorescent staining for complement, oxidative stress, terminal deoxynucleotidyl transferase-mediated nick end-labeling assay-positive cells, and augmented phospho-NF-κB staining were evident in the kidneys of MN serum recipients. However, no histological or clinical manifestations were exhibited by SCID mice that received an adoptive transfer of splenocytes. Adaptive immunity was essential for the development of MN. Specific Igs and their subsequent response contribute to the development of renal injury in cBSA-induced MN.
authors.affiliation: Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. wucc@ndmctsgh.edu.tw
authors.forename: Chia-Chao
authors.initials: CC
authors.lastname: Wu
authors.forename: Kuo-Cheng
authors.initials: KC
authors.lastname: Lu
authors.forename: Yuh-Feng
authors.initials: YF
authors.lastname: Lin
authors.forename: Jin-Shuen
authors.initials: JS
authors.lastname: Chen
authors.forename: Ching-Feng
authors.initials: CF
authors.lastname: Huang
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Chen
authors.forename: Shih-Hua
authors.initials: SH
authors.lastname: Lin
authors.forename: Pauling
authors.initials: P
authors.lastname: Chu
authors.forename: Huey-Kang
authors.initials: HK
authors.lastname: Sytwu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002417:Cattle; D003167:Complement Activation / Q000276:immunology; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress; D012710:Serum Albumin, Bovine / Q000009:adverse effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D016328:NF-kappa B; D012710:Serum Albumin, Bovine
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