title: Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones.
abstract: While much is known about the mechanisms that underlie sleep and circadian rhythms, the investigation into sex differences and gonadal steroid modulation of sleep and biological rhythms is in its infancy. There is a growing recognition of sex disparities in sleep and rhythm disorders. Understanding how neuroendocrine mediators and sex differences influence sleep and biological rhythms is central to advancing our understanding of sleep-related disorders. While it is known that ovarian steroids affect circadian rhythms in rodents, the role of androgen is less understood. Surprising findings that androgens, acting via androgen receptors in the master "circadian clock" within the suprachiasmatic nucleus, modulate photic effects on activity in males point to novel mechanisms of circadian control. Work in aromatase-deficient mice suggests that some sex differences in photic responsiveness are independent of gonadal hormone effects during development. In parallel, aspects of sex differences in sleep are also reported to be independent of gonadal steroids and may involve sex chromosome complement. This a summary of recent work illustrating how sex differences and gonadal hormones influence sleep and circadian rhythms that was presented at a Mini-Symposium at the 2011 annual meeting of the Society for Neuroscience.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, USA. jmong001@umaryland.edu
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Mong
authors.forename: Fiona C
authors.initials: FC
authors.lastname: Baker
authors.forename: Megan M
authors.initials: MM
authors.lastname: Mahoney
authors.forename: Ketema N
authors.initials: KN
authors.lastname: Paul
authors.forename: Michael D
authors.initials: MD
authors.lastname: Schwartz
authors.forename: Kazue
authors.initials: K
authors.lastname: Semba
authors.forename: Rae
authors.initials: R
authors.lastname: Silver
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D004703:Endocrine System / Q000502:physiology*; D005260:Female; D005783:Gender Identity; D042341:Gonadal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D012727:Sex Characteristics; D012890:Sleep / Q000502:physiology*
chemical_list: D042341:Gonadal Hormones
references.citation: Steroids. 2011 Jun;76(7):636-52
references.pmid: 21414337
references.citation: Trends Endocrinol Metab. 2007 Jan-Feb;18(1):4-11
references.pmid: 17140805
references.citation: Sleep. 2006 Jan;29(1):85-93
references.pmid: 16453985
references.citation: Eur J Neurosci. 2009 May;29(9):1820-9
references.pmid: 19473235
references.citation: Exp Neurol. 1969 Dec;25(4):616-25
references.pmid: 5391423
references.citation: Proc Natl Acad Sci U S A. 1972 Jun;69(6):1583-6
references.pmid: 4556464
references.citation: J Psychosom Res. 1976;20(5):509-13
references.pmid: 1003373
references.citation: Am J Physiol. 1980 Jan;238(1):R97-101
references.pmid: 7356053
references.citation: J Sleep Res. 2001 Mar;10(1):19-26
references.pmid: 11285051
references.citation: Sleep. 2004 May 1;27(3):440-4
references.pmid: 15164896
references.citation: J Clin Endocrinol Metab. 2011 Feb;96(2):255-64
references.pmid: 21296989
references.citation: Sleep. 2011 Apr 01;34(4):519-30
references.pmid: 21461331
references.citation: Trends Pharmacol Sci. 2005 Nov;26(11):578-86
references.pmid: 16183137
references.citation: Curr Top Med Chem. 2011;11(8):1047-57
references.pmid: 21401496
references.citation: Menopause. 2001 Jan-Feb;8(1):10-6
references.pmid: 11201509
references.citation: J Comp Neurol. 2001 Jul 16;436(1):64-81
references.pmid: 11413547
references.citation: Proc Natl Acad Sci U S A. 1976 Aug;73(8):2923-7
references.pmid: 1066703
references.citation: J Androl. 1999 Nov-Dec;20(6):731-7
references.pmid: 10591612
references.citation: Brain Res. 2009 Dec 11;1305:74-85
references.pmid: 19769952
references.citation: Brain Res. 1968 Feb;7(2):173-81
references.pmid: 5689033
references.citation: Obes Rev. 2009 Nov;10 Suppl 2:37-45
references.pmid: 19849800
references.citation: Horm Behav. 2006 May;49(5):557-74
references.pmid: 16497305
references.citation: Maturitas. 2011 Mar;68(3):224-32
references.pmid: 21295422
references.citation: J Neurosci. 2006 Feb 22;26(8):2335-42
references.pmid: 16495461
references.citation: Nat Rev Neurosci. 2006 Jun;7(6):477-84
references.pmid: 16688123
references.citation: Nature. 1971 Jan 22;229(5282):261-2
references.pmid: 4323550
references.citation: Eur J Neurosci. 2009 Feb;29(4):795-801
references.pmid: 19200066
references.citation: Sleep. 2007 Oct;30(10):1283-91
references.pmid: 17969462
references.citation: J Neurosci. 2002 Feb 1;22(3):977-90
references.pmid: 11826126
references.citation: J Am Coll Cardiol. 2004 Feb 18;43(4):678-83
references.pmid: 14975482
references.citation: J Psychiatr Res. 1997 May-Jun;31(3):333-46
references.pmid: 9306291
references.citation: Lancet. 1999 Oct 23;354(9188):1435-9
references.pmid: 10543671
references.citation: Exp Neurol. 1966 Jun;15(2):229-39
references.pmid: 4378124
references.citation: Semin Reprod Med. 2010 Sep;28(5):404-21
references.pmid: 20845239
references.citation: Sleep Med. 2011 Mar;12(3):215-21
references.pmid: 21317033
references.citation: Biol Res Nurs. 2010 Jul;12(1):47-53
references.pmid: 20453022
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):318-23
references.pmid: 12518068
references.citation: Brain Res. 1980 Mar 10;185(2):385-98
references.pmid: 6101987
references.citation: J Comp Neurol. 2005 Dec 5;493(1):92-8
references.pmid: 16254994
references.citation: Endocrinology. 2007 Dec;148(12):5640-7
references.pmid: 17901227
references.citation: Proc Natl Acad Sci U S A. 1975 Sep;72(9):3744-7
references.pmid: 1059163
references.citation: J Neurosci. 2004 Jan 7;24(1):68-75
references.pmid: 14715939
references.citation: Sleep Med. 2009 Oct;10(9):1040-6
references.pmid: 19410511
references.citation: Brain Res. 2003 Oct 10;987(1):100-6
references.pmid: 14499951
references.citation: J Clin Endocrinol Metab. 2011 Apr;96(4):E614-23
references.pmid: 21289261
references.citation: Neuroendocrinology. 2002 May;75(5):296-305
references.pmid: 12006783
references.citation: Sleep Med Rev. 2011 Jun;15(3):139-42
references.pmid: 21482156
references.citation: Endocrinology. 2005 Aug;146(8):3280-5
references.pmid: 15905317
references.citation: Horm Behav. 2008 Sep;54(4):565-70
references.pmid: 18590732
references.citation: J Neurosci. 2010 Jul 7;30(27):9140-4
references.pmid: 20610747
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15206-11
references.pmid: 14638944
references.citation: J Nerv Ment Dis. 1966 Nov;143(5):406-16
references.pmid: 5962008
references.citation: Int J Gynaecol Obstet. 2008 Dec;103(3):207-12
references.pmid: 18812241
references.citation: Horm Behav. 2011 Sep;60(4):439-47
references.pmid: 21816154
references.citation: Trends Neurosci. 2005 Mar;28(3):145-51
references.pmid: 15749168
references.citation: Brain Res. 1972 Jul 13;42(1):201-6
references.pmid: 5047187
references.citation: J Biol Rhythms. 1999 Dec;14(6):557-68
references.pmid: 10643753
references.citation: Horm Behav. 2008 Mar;53(3):422-30
references.pmid: 18164002
references.citation: Neuroscience. 2005;130(1):165-83
references.pmid: 15561433
references.citation: Climacteric. 2008 Jun;11(3):233-43
references.pmid: 18568788
references.citation: Brain Res. 1998 Nov 16;811(1-2):96-104
references.pmid: 9804908
references.citation: Physiol Behav. 1971 Jun;6(6):743-6
references.pmid: 4337177
references.citation: J Comp Neurol. 1997 Dec 1;388(4):507-25
references.pmid: 9388012
references.citation: Proc Natl Acad Sci U S A. 2011 Sep 13;108 Suppl 3:15602-8
references.pmid: 21536890
references.citation: Ann N Y Acad Sci. 2008;1129:275-86
references.pmid: 18591488
references.citation: Horm Behav. 2009 May;55(5):570-8
references.pmid: 19446073
references.citation: Am J Physiol. 1983 Jan;244(1):R93-105
references.pmid: 6849422
references.citation: Neuron. 2010 Dec 22;68(6):1023-42
references.pmid: 21172606
references.citation: Eur J Neurosci. 2005 Mar;21(6):1536-46
references.pmid: 15845081
references.citation: Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1328-40
references.pmid: 18753261
references.citation: Med Clin North Am. 2004 May;88(3):705-36, ix
references.pmid: 15087212
references.citation: Front Neuroendocrinol. 2009 Jan;30(1):1-9
references.pmid: 19028515
references.citation: J Neurosci. 1993 Mar;13(3):1065-79
references.pmid: 8441003
references.citation: Brain Res Rev. 2009 Oct;61(2):281-306
references.pmid: 19695288
references.citation: Physiol Behav. 1973 Nov;11(5):609-11
references.pmid: 4355941
references.citation: Nat Neurosci. 2002 Oct;5(10):933-4
references.pmid: 12244322
references.citation: Maturitas. 2007 Feb 20;56(2):212-5
references.pmid: 16950577
references.citation: Neuroscience. 2004;124(3):695-707
references.pmid: 14980739
references.citation: Behav Sleep Med. 2003;1(2):69-80
references.pmid: 15600130
references.citation: Brain Res Gene Expr Patterns. 2002 Oct;1(3-4):151-7
references.pmid: 12638125
references.citation: Neurosci Lett. 2010 Apr 19;474(1):17-21
references.pmid: 20193744
references.citation: Eur J Neurosci. 2002 Oct;16(7):1195-213
references.pmid: 12405980
references.citation: Sleep. 2009 Jul;32(7):857-64
references.pmid: 19639748
references.citation: Biochem Biophys Res Commun. 1998 Nov 18;252(2):445-9
references.pmid: 9826549
references.citation: Sleep Med Rev. 2007 Dec;11(6):429-38
references.pmid: 17936039
references.citation: Pflugers Arch. 2001 Aug;442(5):729-37
references.pmid: 11512029
references.citation: Sleep. 2010 Jul;33(7):956-61
references.pmid: 20614855
references.citation: Recent Prog Horm Res. 1984;40:143-83
references.pmid: 6148772
references.citation: Physiol Behav. 1984 Mar;32(3):357-68
references.pmid: 6463124
references.citation: Int J Endocrinol. 2010;2010:259345
references.pmid: 20145718
references.citation: Eur J Neurosci. 2008 Apr;27(7):1780-92
references.pmid: 18371078
references.citation: Sleep. 1988 Dec;11(6):556-61
references.pmid: 3148991
references.citation: J Clin Endocrinol Metab. 1996 Feb;81(2):728-35
references.pmid: 8636295
references.citation: Neurosci Lett. 2009 Oct 9;463(3):239-43
references.pmid: 19647784
references.citation: Chronobiol Int. 2005;22(5):859-72
references.pmid: 16298772
references.citation: Nat Neurosci. 2011 Jun;14(6):677-83
references.pmid: 21613996
references.citation: Sleep. 1999 Aug 1;22(5):540-55
references.pmid: 10450590
references.citation: Physiol Behav. 1981 Jan;26(1):21-5
references.pmid: 7195042
references.citation: Endocrinology. 1959 Sep;65:369-82
references.pmid: 14432658
references.citation: J Biol Rhythms. 2010 Aug;25(4):288-96
references.pmid: 20679498
references.citation: Science. 1977 Apr 15;196(4287):305-7
references.pmid: 557840
references.citation: Physiol Behav. 1981 May;26(5):825-38
references.pmid: 7267776
references.citation: Hypertension. 2006 May;47(5):833-9
references.pmid: 16585410
references.citation: Sleep. 2006 Sep;29(9):1211-23
references.pmid: 17040009
references.citation: J Neuroendocrinol. 2006 Aug;18(8):567-76
references.pmid: 16867177
references.citation: Nat Rev Neurosci. 2004 Sep;5(9):701-8
references.pmid: 15322528
references.citation: Endocrinology. 2011 May;152(5):1970-8
references.pmid: 21363939
references.citation: J Neurosci. 2003 Nov 19;23(33):10691-702
references.pmid: 14627654
references.citation: J Psychiatr Res. 2005 Jan;39(1):55-76
references.pmid: 15504424
references.citation: Sleep. 2003 Sep;26(6):667-72
references.pmid: 14572118
references.citation: JAMA. 1979 Nov 30;242(22):2405-4
references.pmid: 226735
references.citation: J Appl Physiol (1985). 1996 Jan;80(1):25-9
references.pmid: 8847311
references.citation: Curr Psychiatry Rep. 2002 Dec;4(6):449-60
references.pmid: 12441025
references.citation: Brain Res Brain Res Rev. 2005 Nov;49(3):429-54
references.pmid: 16269313
references.citation: Br Med J. 1971 Apr 24;2(5755):208-10
references.pmid: 5575954
references.citation: J Sleep Res. 2011 Jun;20(2):298-302
references.pmid: 21199039
references.citation: Hypertension. 2007 Oct;50(4):693-700
references.pmid: 17785629
references.citation: Sleep. 2009 Jul;32(7):865-77
references.pmid: 19639749
references.citation: Hum Mol Genet. 1998 Apr;7(4):715-27
references.pmid: 9499427
references.citation: Trends Cogn Sci. 2010 Jun;14(6):259-67
references.pmid: 20418150
references.citation: Am J Obstet Gynecol. 2010 Feb;202(2):171.e1-171.e11
references.pmid: 20035910
references.citation: Am J Physiol. 1981 Jul;241(1):R62-6
references.pmid: 7246802
references.citation: Pediatrics. 2006 Feb;117(2):e247-56
references.pmid: 16452333
references.citation: J Neurosci. 2002 Oct 15;22(20):9005-14
references.pmid: 12388607
references.citation: Physiol Behav. 2011 Oct 24;104(5):962-71
references.pmid: 21722658
references.citation: J Womens Health (Larchmt). 2008 Sep;17(7):1201-8
references.pmid: 18710368