title: Treatment adherence in pediatric eosinophilic gastrointestinal disorders.
abstract: OBJECTIVE
  Examine treatment adherence rates in pediatric eosinophilic gastrointestinal disorders (EGID).
  
  
  METHODS
  Participants were children aged 2.5-18 years with eosinophilic esophagitis or eosinophilic gastroenteritis (EGE) and their caregivers. A multimethod, multi-informant assessment including parent report and electronic monitoring was utilized, with a 90% cut point for nonadherence.
  
  
  RESULTS
  Medication nonadherence prevalence was 30%. Adherence frequency was 91% ± 14% (0-100%) per parent report and 100% ± 69% (0-194%) per electronic monitors. Tube-feeding adherence was 99% ± 3%. Food allergen exposures were less than 1 per 2 weeks, with 33% nonadherence prevalence. Patients with EGE and toddlers with both conditions demonstrated poorer medication adherence (p's < .05). Caregivers reported higher number of missed medication doses than food exposures (p < .05).
  
  
  CONCLUSIONS
  The prevalence and range of nonadherence demonstrates that subsets of these patients are nonadherent. Adherence to treatment in EGID is complex and multifaceted, with nonadherence varying across treatments.
authors.affiliation: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. kevin.hommel@cchmc.org
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Hommel
authors.forename: James P
authors.initials: JP
authors.lastname: Franciosi
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hente
authors.forename: Annette
authors.initials: A
authors.lastname: Ahrens
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004751:Enteritis / Q000628:therapy*; D004802:Eosinophilia / Q000628:therapy*; D057765:Eosinophilic Esophagitis / Q000628:therapy*; D005260:Female; D005756:Gastritis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010290:Parents; D010349:Patient Compliance / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires
references.citation: Med Care. 2001 Aug;39(8):800-12
references.pmid: 11468499
references.citation: Aliment Pharmacol Ther. 2007 Apr 15;25(8):941-7
references.pmid: 17402998
references.citation: J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2
references.pmid: 21477849
references.citation: Pediatrics. 2002 Jul;110(1 Pt 1):e6
references.pmid: 12093987
references.citation: Inflamm Bowel Dis. 2009 Apr;15(4):589-93
references.pmid: 18985746
references.citation: J Pediatr Psychol. 2003 Jul-Aug;28(5):323-33
references.pmid: 12808009
references.citation: J Pediatr Psychol. 2003 Sep;28(6):383-92
references.pmid: 12904450
references.citation: J Pediatr Psychol. 2005 Sep;30(6):492-502
references.pmid: 16055487
references.citation: J Pediatr Psychol. 2005 Dec;30(8):631-43
references.pmid: 15772363
references.citation: Pediatrics. 2005 Dec;116(6):e754-9
references.pmid: 16322131
references.citation: Inflamm Bowel Dis. 2005 Nov;11(11):1006-12
references.pmid: 16239847
references.citation: J Pediatr. 2005 Feb;146(2):177-82
references.pmid: 15689902
references.citation: J Pediatr Endocrinol Metab. 1999 May-Jun;12(3):433-42
references.pmid: 10821223
references.citation: Pediatr Dev Pathol. 2006 May-Jun;9(3):210-8
references.pmid: 16944979
references.citation: J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):526-43
references.pmid: 18955858