title: Meat Science and Muscle Biology Symposium: stem cell niche and postnatal muscle growth.
abstract: Stem cell niche plays a critical role in regulating the behavior and function of adult stem cells that underlie tissue growth, maintenance, and regeneration. In the skeletal muscle, stem cells, called satellite cells, contribute to postnatal muscle growth and hypertrophy, and thus, meat production in agricultural animals. Satellite cells are located adjacent to mature muscle fibers underneath a sheath of basal lamina. Microenvironmental signals from extracellular matrix mediated by the basal lamina and from the host myofiber both impinge on satellite cells to regulate their activity. Furthermore, several types of muscle interstitial cells, including intramuscular preadipocytes and connective tissue fibroblasts, have recently been shown to interact with satellite cells and actively regulate the growth and regeneration of postnatal skeletal muscles. From this regard, interstitial adipogenic cells are not only important for marbling and meat quality, but also represent an additional cellular component of the satellite cell niche. At the molecular level, these interstitial cells may interact with satellite cells through cell surface ligands, such as delta-like 1 homolog (Dlk1) protein whose overexpression is thought to be responsible for muscle hypertrophy in callipyge sheep. In fact, extracellular Dlk1 protein has been shown to promote the myogenic differentiation of satellite cells. Understanding the cellular and molecular mechanisms within the stem cell niche that regulate satellite cell differentiation and maintain muscle homeostasis may lead to promising approaches to optimizing muscle growth and composition, thus improving meat production and quality.
authors.affiliation: Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: P
authors.initials: P
authors.lastname: Bi
authors.forename: S
authors.initials: S
authors.lastname: Kuang
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D008460:Meat / Q000592:standards*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000502:physiology*; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*
chemical_list: D009124:Muscle Proteins
references.citation: Gerontology. 2009;55(2):217-23
references.pmid: 19060453
references.citation: Am J Clin Nutr. 2005 Apr;81(4):903-10
references.pmid: 15817870
references.citation: Nat Cell Biol. 2010 Feb;12(2):153-63
references.pmid: 20081841
references.citation: Meat Sci. 2010 Oct;86(2):456-61
references.pmid: 20598446
references.citation: Cell Stem Cell. 2010 Oct 8;7(4):455-69
references.pmid: 20887952
references.citation: Stem Cell Rev Rep. 2012 Jun;8(2):459-71
references.pmid: 21761283
references.citation: Development. 2010 May;137(10):1586-94
references.pmid: 20430743
references.citation: Anim Genet. 2010 Dec;41(6):642-5
references.pmid: 20412126
references.citation: PLoS One. 2009;4(2):e4352
references.pmid: 19194500
references.citation: Dev Biol. 2004 Nov 15;275(2):375-88
references.pmid: 15501225
references.citation: Biochem Biophys Res Commun. 1985 Jul 16;130(1):440-6
references.pmid: 4026839
references.citation: Bioessays. 2000 Nov;22(11):1049
references.pmid: 11056484
references.citation: Anat Rec. 1971 Aug;170(4):421-35
references.pmid: 5118594
references.citation: J Cell Physiol. 1994 Sep;160(3):563-72
references.pmid: 8077294
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3287-92
references.pmid: 19966309
references.citation: Cell Stem Cell. 2008 Jan 10;2(1):22-31
references.pmid: 18371418
references.citation: Anim Sci J. 2010 Feb;81(1):11-20
references.pmid: 20163667
references.citation: Genet Sel Evol. 2009 Jun 25;41:36
references.pmid: 19555501
references.citation: Mol Biol Cell. 2002 Aug;13(8):2909-18
references.pmid: 12181355
references.citation: J Clin Invest. 2003 Feb;111(4):453-61
references.pmid: 12588883
references.citation: J Biol Chem. 2010 Jun 18;285(25):19483-90
references.pmid: 20382743
references.citation: Curr Biol. 2004 Oct 26;14(20):1858-62
references.pmid: 15498495
references.citation: Cold Spring Harb Symp Quant Biol. 2008;73:67-71
references.pmid: 19022757
references.citation: Mol Cell Endocrinol. 2009 May 25;304(1-2):49-54
references.pmid: 19433247
references.citation: Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E987-98
references.pmid: 19738037
references.citation: J Anim Sci. 2000 Jun;78(6):1485-96
references.pmid: 10875630
references.citation: J Cell Physiol. 2011 Jan;226(1):141-9
references.pmid: 20648565
references.citation: J Biochem. 2010 Jul;148(1):85-92
references.pmid: 20356822
references.citation: Am J Physiol Cell Physiol. 2006 Jun;290(6):C1487-94
references.pmid: 16684931
references.citation: Cell. 2004 Mar 19;116(6):769-78
references.pmid: 15035980
references.citation: PLoS Genet. 2009 Feb;5(2):e1000392
references.pmid: 19247431
references.citation: Nature. 2010 May 13;465(7295):175-81
references.pmid: 20418860
references.citation: Nature. 2006 Nov 30;444(7119):574-9
references.pmid: 17108972
references.citation: Anim Genet. 2009 Apr;40(2):239-41
references.pmid: 19032696
references.citation: J Anim Sci. 2002 Nov;80(11):2833-9
references.pmid: 12462250
references.citation: Curr Opin Cell Biol. 2007 Jun;19(3):281-9
references.pmid: 17467259
references.citation: Leukemia. 2005 Aug;19(8):1404-10
references.pmid: 15959531
references.citation: Stem Cell Res. 2010 Mar;4(2):77-91
references.pmid: 19962952
references.citation: Am J Anat. 1964 Mar;114:235-44
references.pmid: 14131857
references.citation: J Histochem Cytochem. 2000 Aug;48(8):1079-96
references.pmid: 10898801
references.citation: Differentiation. 1996 Mar;60(1):39-45
references.pmid: 8935927
references.citation: Nat Cell Biol. 2006 Jul;8(7):677-87
references.pmid: 16799552
references.citation: Science. 2005 Jul 8;309(5732):314-7
references.pmid: 16002622
references.citation: PLoS One. 2010 Aug 30;5(8):e12479
references.pmid: 20814569
references.citation: J Biophys Biochem Cytol. 1961 Feb;9:493-5
references.pmid: 13768451
references.citation: Exp Cell Res. 2011 Jun 10;317(10):1368-81
references.pmid: 21473864
references.citation: Dev Biol. 2010 Aug 1;344(1):259-71
references.pmid: 20478295
references.citation: Anat Rec. 1982 Mar;202(3):329-37
references.pmid: 7072981
references.citation: Skelet Muscle. 2011 Jan 24;1(1):4
references.pmid: 21798082
references.citation: Genome Res. 2002 Oct;12(10):1496-506
references.pmid: 12368241
references.citation: Annu Rev Cell Dev Biol. 2005;21:605-31
references.pmid: 16212509
references.citation: J Cardiometab Syndr. 2006 Spring;1(2):121-4
references.pmid: 17679816
references.citation: Future Med Chem. 2009 Sep;1(6):1095-1111
references.pmid: 20161478
references.citation: Aging Cell. 2008 Aug;7(4):590-8
references.pmid: 18462272
references.citation: J Mol Biol. 2008 Jun 6;379(3):428-42
references.pmid: 18466921
references.citation: Exp Cell Res. 2010 Feb 1;316(3):341-52
references.pmid: 19853598
references.citation: PLoS Biol. 2007 May;5(5):e102
references.pmid: 17439301
references.citation: Trends Pharmacol Sci. 2002 Dec;23(12):569-75
references.pmid: 12457775
references.citation: Stem Cells Dev. 2008 Aug;17(4):653-67
references.pmid: 18554087
references.citation: J Cell Sci. 2001 Jan;114(Pt 2):303-10
references.pmid: 11148132
references.citation: Int J Dev Biol. 2002;46(4):559-67
references.pmid: 12141444
references.citation: J Cell Biol. 2004 Aug 2;166(3):347-57
references.pmid: 15277541
references.citation: Science. 2010 Aug 27;329(5995):1078-81
references.pmid: 20647425
references.citation: Int J Obes (Lond). 2007 Sep;31(9):1400-5
references.pmid: 17452994
references.citation: Cell. 2002 Nov 15;111(4):589-601
references.pmid: 12437931
references.citation: Am J Med Genet C Semin Med Genet. 2010 Aug 15;154C(3):317-20
references.pmid: 20803653
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11470-5
references.pmid: 21709251
references.citation: J Mol Biol. 2007 Apr 13;367(5):1281-93
references.pmid: 17320900
references.citation: Nature. 2002 Aug 15;418(6899):797-801
references.pmid: 12181572
references.citation: PLoS One. 2011 Mar 09;6(3):e17392
references.pmid: 21408055
references.citation: Trends Mol Med. 2008 Feb;14(2):82-91
references.pmid: 18218339
references.citation: Biochim Biophys Acta. 2011 Jun;1813(6):1153-64
references.pmid: 21419176
references.citation: Cell. 2005 Jul 29;122(2):289-301
references.pmid: 16051152
references.citation: J Anim Sci. 2011 Jan;89(1):185-91
references.pmid: 20889683
references.citation: Am J Physiol Cell Physiol. 2009 Jun;296(6):C1321-8
references.pmid: 19386789
references.citation: Blood Cells. 1978;4(1-2):7-25
references.pmid: 747780
references.citation: J Histochem Cytochem. 2011 Jan;59(1):33-46
references.pmid: 21339173
references.citation: Adv Exp Med Biol. 2008;626:101-15
references.pmid: 18372794
references.citation: Biol Res. 2004;37(4):635-9
references.pmid: 15712402
references.citation: Cell Stem Cell. 2009 Jun 5;4(6):507-10
references.pmid: 19497279
references.citation: Nat Cell Biol. 2010 Mar;12(3):257-66
references.pmid: 20118923
references.citation: Nature. 2011 Jul 20;475(7356):381-5
references.pmid: 21776083
references.citation: J Muscle Res Cell Motil. 1995 Dec;16(6):619-28
references.pmid: 8750233
references.citation: Development. 2011 Sep;138(17):3625-37
references.pmid: 21828091
references.citation: Dev Biol. 2012 Jan 1;361(1):27-38
references.pmid: 22037676
references.citation: Dev Biol. 1986 May;115(1):140-7
references.pmid: 3699242
references.citation: Mol Biol Cell. 2009 Jul;20(14):3353-62
references.pmid: 19477929
references.citation: Exp Cell Res. 2010 Jun 10;316(10):1681-91
references.pmid: 20385127
references.citation: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8119-24
references.pmid: 16690740
references.citation: J Cell Biol. 2002 Oct 14;159(1):123-34
references.pmid: 12379804
references.citation: Growth Factors. 1997;15(1):1-27
references.pmid: 9401815
references.citation: Int J Biol Sci. 2010 Aug 31;6(5):465-74
references.pmid: 20827399
references.citation: Cell Stem Cell. 2009 Sep 4;5(3):298-309
references.pmid: 19733541
references.citation: J Cell Biochem. 1996 Aug;62(2):227-39
references.pmid: 8844403
references.citation: Cell. 2008 Feb 22;132(4):583-97
references.pmid: 18295577
references.citation: Mol Biol Cell. 2010 Mar 15;21(6):848-59
references.pmid: 20089845
references.citation: Am J Physiol Cell Physiol. 2003 Aug;285(2):C370-6
references.pmid: 12711593
references.citation: Anim Genet. 2003 Oct;34(5):349-53
references.pmid: 14510670
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21866-71
references.pmid: 21106753
references.citation: Dev Biol. 2006 Jun 1;294(1):50-66
references.pmid: 16554047
references.citation: Dev Dyn. 2004 Nov;231(3):489-502
references.pmid: 15390217
references.citation: PLoS One. 2010 Nov 29;5(11):e15055
references.pmid: 21124733
references.citation: Am J Physiol. 1989 Jun;256(6 Pt 1):C1262-6
references.pmid: 2735398
references.citation: Circ Res. 2011 Sep 2;109(6):670-9
references.pmid: 21778430
references.citation: Mol Ther. 2009 Oct;17(10):1788-98
references.pmid: 19603004
references.citation: Development. 2011 Sep;138(17):3639-46
references.pmid: 21828092
references.citation: Anim Genet. 2011 Aug;42(4):361-5
references.pmid: 21749418
references.citation: Science. 2001 Aug 10;293(5532):1086-9
references.pmid: 11498578
references.citation: Horm Res. 2006;65 Suppl 3:50-8
references.pmid: 16612114
references.citation: J Cell Biol. 2000 Dec 11;151(6):1221-34
references.pmid: 11121437
references.citation: Stem Cells. 2009 Apr;27(4):898-908
references.pmid: 19353518
references.citation: Am J Sports Med. 2011 Sep;39(9):1912-22
references.pmid: 21828363
references.citation: Dev Biol. 2009 Aug 1;332(1):131-41
references.pmid: 19464281
references.citation: Tissue Eng Part B Rev. 2008 Dec;14(4):419-31
references.pmid: 18817477
references.citation: Meat Sci. 2010 Sep;86(1):166-70
references.pmid: 20605337
references.citation: Mol Cancer Res. 2007 Jul;5(7):655-65
references.pmid: 17634421
references.citation: J Anim Sci. 1996 Feb;74(2):388-93
references.pmid: 8690675
references.citation: Am J Pathol. 2009 Feb;174(2):541-9
references.pmid: 19147819
references.citation: Mol Biol Rep. 2012 Apr;39(4):3943-50
references.pmid: 21748318
references.citation: Am J Physiol Cell Physiol. 2009 Aug;297(2):C238-52
references.pmid: 19515904
references.citation: Obes Rev. 2011 May;12(5):e504-15
references.pmid: 21348916
references.citation: Med Sci (Paris). 2011 May;27(5):521-6
references.pmid: 21609674
references.citation: Int J Cancer. 2009 Feb 15;124(4):869-76
references.pmid: 19035456
references.citation: J Cell Physiol. 2010 Jan;222(1):17-22
references.pmid: 19725055
references.citation: EMBO J. 2001 Nov 15;20(22):6414-23
references.pmid: 11707412
references.citation: Obesity (Silver Spring). 2006 Mar;14(3):357-67
references.pmid: 16648604
references.citation: Dev Biol. 1997 Aug 1;188(1):167-80
references.pmid: 9245520
references.citation: J Pathol. 2003 Sep;201(1):149-59
references.pmid: 12950028
references.citation: Cell. 2007 Jun 1;129(5):999-1010
references.pmid: 17540178
references.citation: J Histochem Cytochem. 1999 Jan;47(1):23-42
references.pmid: 9857210
references.citation: J Clin Invest. 2004 Jul;114(2):182-95
references.pmid: 15254585
references.citation: Physiol Rev. 1996 Apr;76(2):371-423
references.pmid: 8618961
references.citation: Cell Metab. 2008 Jan;7(1):33-44
references.pmid: 18177723
references.citation: Muscle Nerve. 1982 Feb;5(2):152-61
references.pmid: 7070396
references.citation: J Cell Biol. 1999 Nov 15;147(4):869-78
references.pmid: 10562287
references.citation: J Cell Physiol. 2012 Apr;227(4):1465-75
references.pmid: 21618537
references.citation: Development. 2011 Jan;138(2):371-84
references.pmid: 21177349
references.citation: FEBS Lett. 2007 Nov 13;581(27):5178-84
references.pmid: 17959172
references.citation: Int J Biol Sci. 2010 Nov 22;6(7):691-9
references.pmid: 21103072
references.citation: Annu Rev Biochem. 2006;75:19-37
references.pmid: 16756483
references.citation: Mol Cell Biol. 2002 Aug;22(15):5585-92
references.pmid: 12101250
references.citation: Development. 2011 Sep;138(17):3647-56
references.pmid: 21828093
references.citation: J Mol Biol. 2007 Apr 13;367(5):1270-80
references.pmid: 17320102
references.citation: Mol Biol Cell. 2007 Apr;18(4):1397-409
references.pmid: 17287398
references.citation: Nat Cell Biol. 2007 Mar;9(3):255-67
references.pmid: 17293855
references.citation: Am J Physiol Cell Physiol. 2009 Aug;297(2):C227-30
references.pmid: 19535512