title: Caffeine-induced synaptic potentiation in hippocampal CA2 neurons.
abstract: Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A(1) adenosine receptors (A(1)Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A(1)R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.
authors.affiliation: National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Simons
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Caruana
authors.forename: Meilan
authors.initials: M
authors.lastname: Zhao
authors.forename: Serena M
authors.initials: SM
authors.lastname: Dudek
mesh_terms: D000818:Animals; D056651:CA2 Region, Hippocampal / Q000187:drug effects* / Q000502:physiology; D002110:Caffeine / Q000494:pharmacology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D002110:Caffeine
references.citation: Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16994-8
references.pmid: 20837545
references.citation: Neuron. 1994 May;12(5):1139-48
references.pmid: 8185949
references.citation: Neuron. 1991 Jul;7(1):17-25
references.pmid: 1648939
references.citation: Biol Psychiatry. 1998 Jul 15;44(2):88-97
references.pmid: 9646890
references.citation: Neurosci Lett. 2005 Mar 16;376(3):160-5
references.pmid: 15721214
references.citation: Neurosci Lett. 1992 Jan 20;135(1):10-2
references.pmid: 1311819
references.citation: Life Sci. 1988;43(5):387-98
references.pmid: 2456442
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14080-4
references.pmid: 19666491
references.citation: Hippocampus. 1995;5(1):71-7
references.pmid: 7787948
references.citation: Neuroscience. 1999;93(3):955-67
references.pmid: 10473260
references.citation: Mol Psychiatry. 2002;7(9):975-84
references.pmid: 12399951
references.citation: Biol Psychiatry. 1990 Jul 1;28(1):35-40
references.pmid: 2375945
references.citation: Annu Rev Neurosci. 2001;24:31-55
references.pmid: 11283304
references.citation: J Neurosci. 2007 Oct 31;27(44):12025-32
references.pmid: 17978044
references.citation: Brain Res. 1992 Dec 11;598(1-2):173-84
references.pmid: 1486479