title: Update on ischemia-reperfusion injury for the plastic surgeon:  2011.
abstract: Ischemia-reperfusion injury occurs when tissue is reperfused following a prolonged period of ischemia. It is a subject of interest to plastic surgeons involved in replantation, free tissue transfer, and composite tissue allotransplantation, as it can have a significant impact on the overall success of these procedures. The purpose of this article is to review the recent progress in the investigation of ischemia-reperfusion injury in skeletal muscle and skin and to highlight the potential clinical implications of therapeutic interventions aimed at reducing ischemia-reperfusion injury.
authors.affiliation: Las Vegas, Nev. From the Department of Surgery, Division of Plastic Surgery, University of Nevada School of Medicine.
authors.forename: Wei Z
authors.initials: WZ
authors.lastname: Wang
authors.forename: Richard C
authors.initials: RC
authors.lastname: Baynosa
authors.forename: William A
authors.initials: WA
authors.lastname: Zamboni
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D058752:Free Tissue Flaps / Q000098:blood supply*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019194:Ischemic Preconditioning / Q000379:methods; D053078:Membrane Potential, Mitochondrial / Q000502:physiology; D051379:Mice; D008866:Microsurgery; D008931:Mitochondria, Muscle / Q000502:physiology; D051336:Mitochondrial Membranes / Q000502:physiology; D018482:Muscle, Skeletal / Q000098:blood supply*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000628:therapy; D012092:Replantation; D012867:Skin / Q000098:blood supply*; D014022:Tissue Survival; D014184:Transplantation, Homologous; D019737:Transplants
chemical_list: D017382:Reactive Oxygen Species