title: Regiospecific synthesis of 1,2-disubstituted (hetero)aryl fused imidazoles with tunable fluorescent emission.
abstract: A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
authors.forename: Dongbing
authors.initials: D
authors.lastname: Zhao
authors.forename: Junyi
authors.initials: J
authors.lastname: Hu
authors.forename: Ningjie
authors.initials: N
authors.lastname: Wu
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Huang
authors.forename: Xurong
authors.initials: X
authors.lastname: Qin
authors.forename: Jingbo
authors.initials: J
authors.lastname: Lan
authors.forename: Jingsong
authors.initials: J
authors.lastname: You
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D007093:Imidazoles; D010165:Palladium