title: Developing a community-based genetic nomenclature for anole lizards.
abstract: BACKGROUND
  Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics.
  
  
  RESULTS
  Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) and propose a standardized evolutionary characterization code that will help researchers to define gene orthology and paralogy with tetrapod homologs, provide a system for naming novel genes in Anolis and other reptiles, furnish abbreviations to facilitate comparative studies among the Anolis species and related iguanid squamates, and classify the geographical origins of Anolis subpopulations.
  
  
  CONCLUSIONS
  This report has been generated in close consultation with members of the Anolis and genomic research communities, and using public database resources including NCBI and Ensembl. Updates will continue to be regularly posted to new research community websites such as lizardbase. We anticipate that this standardized gene nomenclature will facilitate the accessibility of reptilian sequences for comparative studies among tetrapods and will further serve as a template for other communities in their sequencing and annotation initiatives.
authors.affiliation: School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ 85287-4501, USA. kenro.kusumi@asu.edu
authors.forename: Kenro
authors.initials: K
authors.lastname: Kusumi
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Kulathinal
authors.forename: Arhat
authors.initials: A
authors.lastname: Abzhanov
authors.forename: Stephane
authors.initials: S
authors.lastname: Boissinot
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Crawford
authors.forename: Brant C
authors.initials: BC
authors.lastname: Faircloth
authors.forename: Travis C
authors.initials: TC
authors.lastname: Glenn
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Janes
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Losos
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Menke
authors.forename: Steven
authors.initials: S
authors.lastname: Poe
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Sanger
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schneider
authors.forename: Jessica
authors.initials: J
authors.lastname: Stapley
authors.forename: Juli
authors.initials: J
authors.lastname: Wade
authors.forename: Jeanne
authors.initials: J
authors.lastname: Wilson-Rawls
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005819:Genetic Markers; D023281:Genomics / Q000592:standards*; D008116:Lizards / Q000145:classification / Q000235:genetics*; D018895:Microsatellite Repeats; D012091:Repetitive Sequences, Nucleic Acid; D009626:Terminology as Topic
chemical_list: D004251:DNA Transposable Elements; D005819:Genetic Markers
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