title: Copper and its complexes in medicine: a biochemical approach.
abstract: The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of a novel generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to summarize all the available-to-date information on these issues.
authors.affiliation: Department of Physics Chemistry & Materials Technology, Technological Educational Institute of Athens, 12210 Athens, Greece.
authors.forename: Isidoros
authors.initials: I
authors.lastname: Iakovidis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Delimaris
authors.forename: Stylianos M
authors.initials: SM
authors.lastname: Piperakis
references.citation: Chem Biol Interact. 2007 Feb 20;165(3):189-99
references.pmid: 17217939
references.citation: Biochem Pharmacol. 2003 Jun 15;65(12):1979-89
references.pmid: 12787878
references.citation: Chem Biol Interact. 2010 Jul 30;186(2):184-99
references.pmid: 20399203
references.citation: Biochimie. 2009 Oct;91(10):1212-7
references.pmid: 19332103
references.citation: Arch Neurol. 2006 Aug;63(8):1085-8
references.pmid: 16908733
references.citation: J Inorg Biochem. 2009 Dec;103(12):1644-51
references.pmid: 19822369
references.citation: Eur J Med Chem. 2005 Dec;40(12):1414-9
references.pmid: 16129515
references.citation: J Trace Elem Med Biol. 2000 Oct;14(3):174-8
references.pmid: 11130855
references.citation: Curr Opin Chem Biol. 2002 Apr;6(2):171-80
references.pmid: 12039001
references.citation: Med Res Rev. 2010 Jul;30(4):708-49
references.pmid: 19626597
references.citation: Eur J Med Chem. 2009 Nov;44(11):4353-61
references.pmid: 19559507
references.citation: Z Naturforsch C J Biosci. 2004 Jul-Aug;59(7-8):609-11
references.pmid: 15813388
references.citation: J Inorg Biochem. 2007 Jan;101(1):64-73
references.pmid: 17027085
references.citation: J Inorg Biochem. 2007 Apr;101(4):649-59
references.pmid: 17292964
references.citation: Bioorg Med Chem Lett. 2006 Dec 1;16(23):5982-7
references.pmid: 16987659
references.citation: N Engl J Med. 2008 Feb 7;358(6):605-14
references.pmid: 18256395
references.citation: J Hepatol. 2005;42 Suppl(1):S13-21
references.pmid: 15777568
references.citation: Mol Genet Metab. 2008 Nov;95(3):174-81
references.pmid: 18752978
references.citation: Biophys J. 2006 Jun 1;90(11):3865-79
references.pmid: 16513784
references.citation: Biometals. 2010 Apr;23(2):265-73
references.pmid: 20012769
references.citation: Toxicology. 2003 Jul 15;189(1-2):147-63
references.pmid: 12821289
references.citation: FASEB J. 2004 Nov;18(14):1728-30
references.pmid: 15345689
references.citation: J Inorg Biochem. 2011 Feb;105(2):119-26
references.pmid: 21194609
references.citation: Bioorg Med Chem. 2010 Feb;18(3):1227-35
references.pmid: 20045652
references.citation: J Inorg Biochem. 2011 May;105(5):728-37
references.pmid: 21463568
references.citation: Biometals. 2003 Mar;16(1):205-13
references.pmid: 12572680
references.citation: Hepatology. 2004 Apr;39(4):963-9
references.pmid: 15057900
references.citation: J Inorg Biochem. 2008 Apr;102(4):910-20
references.pmid: 18242712
references.citation: Am J Clin Nutr. 1998 May;67(5 Suppl):972S-977S
references.pmid: 9587138
references.citation: J Inorg Biochem. 2006 Feb;100(2):299-304
references.pmid: 16387362
references.citation: Appl Environ Microbiol. 2007 Apr;73(8):2748-50
references.pmid: 17259354
references.citation: Mol Aspects Med. 2005 Aug-Oct;26(4-5):313-27
references.pmid: 16112186
references.citation: Biochim Biophys Acta. 1997 Feb 27;1360(1):3-16
references.pmid: 9061035
references.citation: Indian J Cancer. 2007 Apr-Jun;44(2):62-71
references.pmid: 17938483
references.citation: Nutr J. 2005 Nov 24;4:35
references.pmid: 16307684
references.citation: Curr Opin Chem Biol. 2003 Apr;7(2):207-12
references.pmid: 12714053
references.citation: Brain Res. 2010 Mar 10;1319:118-30
references.pmid: 20026314
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11065-9
references.pmid: 12920183
references.citation: Brain Res Rev. 2007 Apr;54(1):19-33
references.pmid: 17270275
references.citation: J Neural Transm Park Dis Dement Sect. 1991;3(4):231-58
references.pmid: 1772577
references.citation: Biochem Pharmacol. 2004 Mar 15;67(6):1139-51
references.pmid: 15006550
references.citation: J Inorg Biochem. 2001 Mar;84(1-2):23-32
references.pmid: 11330478
references.citation: Clin Chem. 1993 May;39(5):883-7
references.pmid: 8387409
references.citation: Eur Cytokine Netw. 2005 Dec;16(4):261-5
references.pmid: 16464739
references.citation: Endocr Relat Cancer. 2004 Jun;11(2):255-63
references.pmid: 15163301
references.citation: Am J Clin Pathol. 2009 Feb;131(2):160-5
references.pmid: 19141375
references.citation: Agents Actions. 1984 Dec;15(5-6):513-9
references.pmid: 6099692
references.citation: Clin Chem. 1994 Aug;40(8):1479-84
references.pmid: 8044985
references.citation: J Inorg Biochem. 2009 Mar;103(3):432-40
references.pmid: 19171383
references.citation: Clin Biochem. 2008 Jun;41(9):706-11
references.pmid: 18294962
references.citation: Mol Aspects Med. 2005 Aug-Oct;26(4-5):268-98
references.pmid: 16112185
references.citation: Clin Rheumatol. 1998;17(5):378-82
references.pmid: 9805181
references.citation: J Inorg Biochem. 2000 Jul 15;81(1-2):23-7
references.pmid: 11001427
references.citation: J Med Chem. 2008 Feb 14;51(3):470-8
references.pmid: 18205294
references.citation: Neurotoxicology. 2009 Nov;30(6):996-9
references.pmid: 19732792
references.citation: Free Radic Biol Med. 2011 Jan 1;50(1):110-21
references.pmid: 20971185
references.citation: Biochim Biophys Acta. 2006 Jul;1763(7):737-46
references.pmid: 16784785
references.citation: Br J Nutr. 2008 Jun;99 Suppl 3:S10-3
references.pmid: 18598583
references.citation: Biochem J. 2008 May 15;412(1):141-52
references.pmid: 18248325
references.citation: Biomed Pharmacother. 2003 Nov;57(9):386-98
references.pmid: 14652164
references.citation: Biochem Pharmacol. 2002 May 15;63(10):1863-73
references.pmid: 12034371
references.citation: Eur J Med Chem. 2008 May;43(5):939-48
references.pmid: 17709156
references.citation: J Inorg Biochem. 2005 Nov;99(11):2102-9
references.pmid: 16144711
references.citation: Cancer Treat Rev. 2009 Feb;35(1):32-46
references.pmid: 18774652
references.citation: Gastroenterology. 2003 Dec;125(6):1868-77
references.pmid: 14724838
references.citation: Br J Nutr. 2003 Jul;90(1):161-8
references.pmid: 12844388
references.citation: Br J Nutr. 2002 May;87(5):393-403
references.pmid: 12010579
references.citation: J Inorg Biochem. 2005 Mar;99(3):677-89
references.pmid: 15708788
references.citation: Eur J Med Chem. 2010 Jul;45(7):2893-901
references.pmid: 20362358
references.citation: J Alzheimers Dis. 2009;18(4):811-7
references.pmid: 19749401
references.citation: J Am Coll Nutr. 2009 Jun;28(3):238-42
references.pmid: 20150596
references.citation: J Inorg Biochem. 2005 Dec;99(12):2403-22
references.pmid: 16271394
references.citation: J Inorg Biochem. 2006 Nov;100(11):1764-73
references.pmid: 16904184
references.citation: Front Biosci. 2005 Sep 01;10:2932-9
references.pmid: 15970547
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2002 Apr;58(6):1227-39
references.pmid: 11993471
references.citation: J Biol Chem. 2002 Nov 1;277(44):42017-27
references.pmid: 12183464
references.citation: Biochim Biophys Acta. 2002 Nov 14;1573(2):149-55
references.pmid: 12399024
references.citation: J Inorg Biochem. 2011 Jun;105(6):894-901
references.pmid: 21513690
references.citation: Toxicol Appl Pharmacol. 2008 Aug 15;231(1):24-33
references.pmid: 18501397