title: [Mechanisms of cellular senescence by tumor suppressor p53].
abstract: Cellular senescence is a complexity of ageing and cancer biology. As malignant tumors can culminate individuals in life-termination, evolution has provided multicellular organisms with an acquisition of distinctive safety device, cellular senescence, to circumvent the development. Diploid cells, indeed, sense accumulation of hostile stresses such as genomic integrity, metabolic dysfunction and oncogene-induced mitotic signals, leading to activation of cell cycle arrest and/or programmed cell death. A tumor suppressor, p53, has been reported to function as a governing center to defend against these malignant transformations. Here we review how p53 cooperate with adverse stresses to drive cellular senescence, providing a framework for intricate molecular cross-talks.
authors.affiliation: Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*
chemical_list: C106253:LOC133728 protein, human; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface