title: Activation of autophagy is required for muscle homeostasis during physical exercise.
abstract: Skeletal muscle fibers of collagen VI null (Col6a12/2) mice show signs of degeneration due to a block in autophagy, leading to the accumulation of damaged mitochondria and excessive apoptosis. Attempts to induce autophagic flux by subjecting these mutant mice to long-term or shorter bursts of physical activity are unsuccessful (see Grumati, et al., pp. 1415–23). In normal mice, the induction of autophagy in the skeletal muscles post-exercise is able to prevent the accumulation of damaged organelles and maintain cellular homeostasis. Thus, these studies provide an important connection between autophagy and exercise physiology.
authors.forename: Usha
authors.initials: U
authors.lastname: Nair
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klionsky
mesh_terms: D000818:Animals; D001343:Autophagy; D024142:Collagen Type VI / Q000172:deficiency*; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology*; D010805:Physical Conditioning, Animal
chemical_list: C540085:Col6a1 protein, mouse; D024142:Collagen Type VI
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