title: Association between 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies.
abstract: The objective is to determine the association between the 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in an intervention and a cross-sectional studies. In the 4-weeks intervention study, Japanese men (n = 10) consumed the test diet in week 1, and the test diet plus varying amounts of α-tocopherol in the three subsequent weeks: 21 μmol/d α-tocopherol in week 2, 63 μmol/d in week 3, and 125 μmol/d in week 4. A significant association between α-tocopherol intake and urinary α-CEHC was observed in this strictly controlled experiment (r = 0.99, p<0.001). In the cross-sectional study, all foods consumed over 4 consecutive days were recorded in 76 free-living young subjects (18-33 years). The association was weak, but a significant relationship was observed (r = 0.29, p<0.05) even in the cross-sectional study. In the cross-sectional study adults, mean estimated α-tocopherol intake calculated by urinary α-CEHC and the excretory ratio was 91% of their mean intake over the 4 days. The results show that urinary α-CEHC level reflected recent α-tocopherol intake in free-living young Japanese adults, and could be used as a measure of intake during the previous few days, both for group means and for individual rankings within a group.
authors.affiliation: Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Imai
authors.forename: Tomiko
authors.initials: T
authors.lastname: Tsuji
authors.forename: Mitsue
authors.initials: M
authors.lastname: Sano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D002839:Chromans / Q000652:urine*; D003430:Cross-Sectional Studies; D015930:Diet Records; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D011422:Propionates / Q000652:urine*; D015203:Reproducibility of Results; D016482:Urinalysis / Q000592:standards; D055815:Young Adult; D024502:alpha-Tocopherol / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D002839:Chromans; D011422:Propionates; C084852:2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman; D024502:alpha-Tocopherol