title: Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.
abstract: Asthma is a persistent inflammatory disease characterized by airway obstruction and hyperresponsiveness in association with airway inflammation. In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. TA significantly inhibited increases in IgE, levels of ROS and T helper cytokines, such as interleukin (IL)-4, IL-5, TNF-α, and IL-13, in bronchoalveolar lavage fluid (BALF), and effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion in the asthmatic mouse model. In addition, we found that administration of TA attenuated ovalbumin-induced increases in NF-κB activity in lungs. The efficacy of TA was comparable to that of montelukast, a currently available anti-asthmatic drug. Our results support the utility of TA as a herbal medicine for asthma treatment and may have application in the development of anti-inflammatory and anti-asthmatic drugs.
authors.affiliation: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Exporo 483, Yusung, Daejeon 305-811, South Korea.
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Kyung-Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Lim
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Yuk
authors.forename: Ok-Kyoung
authors.initials: OK
authors.lastname: Kwon
authors.forename: Kyoung-Youl
authors.initials: KY
authors.lastname: Lee
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000188:drug therapy / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D007958:Leukocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010047:Ovalbumin; D008517:Phytotherapy; D051996:Transcription Factor RelA / Q000276:immunology; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: C494851:3beta,6beta-dihydroxyolean-12-en-27-oic acid; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D051996:Transcription Factor RelA; D014315:Triterpenes; C464534:tiarellic acid; D007073:Immunoglobulin E; D009828:Oleanolic Acid; D010047:Ovalbumin