title: Detection of torque teno midi virus/small anellovirus (TTMDV/SAV) in chronic cervicitis and cervical tumors in Isfahan, Iran.
abstract: Torque teno midi virus and small anellovirus (TTMDV/SAV) are members of the genus Gammatorquevirus within the family Anelloviridae. Cervical cancer is the second most prevalent cancer after breast cancer. The aim of this study was to determine the frequency of infection by these viruses in cervicitis and cervical tumors of women from Isfahan, Iran. Formalin-fixed, paraffin-embedded tissue samples from cervical cancers (n = 42) and cervicitis cases (n = 79) were subjected to nested PCR to identify TTMDV/SAV viral sequences. Of the 42 tumor cases, 22, 18 and 2 were diagnosed as adenocarcinoma, cervical intraepithelial neoplasia and squamous cell carcinoma, respectively. In total, 23 (55%) of the tumor samples were positive for TTMDV/SAV. Of the 79 cervicitis cases, 38 (48%) were also positive for TTMDV/SAV. This is the first report of TTMDV/SAV in cervicitis and cervical tumors of women.
authors.affiliation: Department of Biology, University of Isfahan, 81746-73441 Isfahan, Iran. sharare.salmanizade@yahoo.com
authors.forename: Sharareh
authors.initials: S
authors.lastname: Salmanizadeh
authors.forename: Majid
authors.initials: M
authors.lastname: Bouzari
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000821:virology; D005260:Female; D006801:Humans; D007492:Iran; D008969:Molecular Sequence Data; D010802:Phylogeny; D022783:Torque teno virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D002575:Uterine Cervicitis / Q000821:virology*