title: Amiodarone-induced thyrotoxicosis with thyroid papillary cancer in multinodular goiter: case report.
abstract: OBJECTIVE
  To report a case of amiodarone-induced thyrotoxicosis (AIT) concomitant with thyroid cancer in multinodular goiter (MNG).
  
  
  METHODS
  A 61-year-old man treated with amiodarone for 5 years presented with mild sweating. He was found to have AIT simultaneously with thyroid papillary cancer and MNG. Administration of amiodarone was stopped, and he was treated with methimazole for AIT. Five weeks after the initial treatment, thyroid function normalized. Total thyroidectomy was considered to enable use of amiodarone again.
  
  
  CONCLUSIONS
  This case showed that thyrotoxicosis, MNG and amiodarone may contribute to thyroid carcinogenesis. Amiodarone should be carefully commenced in cases with MNG.
authors.affiliation: Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan. inabaaa2000@yahoo.co.jp
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Inaba
authors.forename: Satoru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Teiji
authors.initials: T
authors.lastname: Takeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Akamizu
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Komatsu
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002277:Carcinoma; D002291:Carcinoma, Papillary / Q000150:complications*; D006044:Goiter, Nodular / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000188:drug therapy*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000150:complications*; D013971:Thyrotoxicosis / Q000139:chemically induced*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone