title: Hypermethylation of repetitive DNA elements in livers of mice fed an atherogenic diet.
abstract: OBJECTIVE
  DNA methylation status was examined in C57BL/6J obese mice fed an atherogenic diet (AD) to establish the correlation between epigenetic alterations and obesity-related abnormalities.
  
  
  METHODS
  Six-week-old male C57BL/6J mice were fed a normal diet (ND) or AD for 8 wk. Methylation levels of global DNA and repetitive DNA elements in livers of ND-fed mice and AD-fed mice were examined.
  
  
  RESULTS
  The total amounts of 5-MeC genomic contents in livers of AD-fed mice were increased as compared with those of ND-fed mice. Hypermethylation of repetitive DNA elements was observed in livers of AD-fed mice.
  
  
  CONCLUSIONS
  Hypermethylation of repetitive DNA elements in livers of AD-fed mice proposes epigenetic changes by nutritional intervention.
authors.affiliation: Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Taekyung
authors.initials: T
authors.lastname: Yoo
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Yoon
authors.forename: Soo Hee
authors.initials: SH
authors.lastname: Ryu
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Ahn
authors.forename: Suna
authors.initials: S
authors.lastname: Kim
authors.forename: Tae Youl
authors.initials: TY
authors.lastname: Ha
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Chung
authors.forename: Cheol O
authors.initials: CO
authors.lastname: Joe
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D019175:DNA Methylation; D004036:Diet, Atherogenic; D044127:Epigenesis, Genetic; D016678:Genome; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004247:DNA