title: Clostridium difficile mixed infection and reinfection.
abstract: Isolates from consecutive Clostridium difficile infection (CDI) fecal samples underwent multilocus sequence typing. Potential reinfections with different genotypes were identified in 88/560 (16%) sample pairs taken 1 to 1,414 days (median, 24; interquartile range [IQR], 1 to 52 days) apart; odds of reinfection increased by 58% for every doubling of time between samples. Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype.
authors.affiliation: NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom. david.eyre@ndm.ox.ac.uk
authors.forename: David W
authors.initials: DW
authors.lastname: Eyre
authors.forename: A Sarah
authors.initials: AS
authors.lastname: Walker
authors.forename: David
authors.initials: D
authors.lastname: Griffiths
authors.forename: Mark H
authors.initials: MH
authors.lastname: Wilcox
authors.forename: David H
authors.initials: DH
authors.lastname: Wyllie
authors.forename: Kate E
authors.initials: KE
authors.lastname: Dingle
authors.forename: Derrick W
authors.initials: DW
authors.lastname: Crook
authors.forename: Tim E A
authors.initials: TE
authors.lastname: Peto
mesh_terms: D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000175:diagnosis* / Q000382:microbiology*; D016000:Cluster Analysis; D060085:Coinfection / Q000175:diagnosis* / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D058885:Multilocus Sequence Typing; D012008:Recurrence
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