title: Neutrons, magnets, and photons: a career in structural biology.
abstract: The purpose of Reflections articles, it seems, is to give elderly scientists a chance to write about the "good old days," when everyone walked to school in the snow. They enjoy this activity so much that your editor, Martha Fedor, must have known that I would accept her invitation to write such an article, no matter how much I demurred at first. As everyone knows, flattery will get you everywhere. It may comfort the apprehensive reader to learn that there is not going to be much walking to school in the snow in this story. On the contrary, rather than thinking how hard I had it during my scientific career, I find it inconceivable that anyone could have had a smoother ride. At the time I began my career, science was an expanding enterprise in the United States that welcomed the young. Only in such an opportunity-rich environment would someone like me have stood a chance. The contrast between that world and the dog-eat-dog world young scientists confront today is stark.
authors.affiliation: Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA. peter.moore@yale.edu
authors.forename: Peter B
authors.initials: PB
authors.lastname: Moore
mesh_terms: D001671:Biochemistry / Q000266:history* / Q000379:methods; D049673:History, 20th Century; D049674:History, 21st Century; D059346:Magnets; D009502:Neutrons; D017785:Photons
references.citation: Mol Cell. 2007 Apr 27;26(2):205-15
references.pmid: 17466623
references.citation: Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9581-5
references.pmid: 8415744
references.citation: J Mol Biol. 1966 Jun;18(1):21-37
references.pmid: 5337556
references.citation: Proc Natl Acad Sci U S A. 1975 Oct;72(10):3888-92
references.pmid: 1105567
references.citation: J Mol Biol. 1970 Jun 14;50(2):279-95
references.pmid: 5476917
references.citation: Proc Natl Acad Sci U S A. 1964 Dec;52:1367-74
references.pmid: 14243510
references.citation: J Mol Biol. 1968 Feb 14;31(3):441-61
references.pmid: 4866333
references.citation: Science. 2000 Aug 11;289(5481):905-20
references.pmid: 10937989
references.citation: RNA. 2004 Jun;10(6):954-64
references.pmid: 15146079
references.citation: Science. 2010 Nov 26;330(6008):1203-9
references.pmid: 21109664
references.citation: Science. 1987 Dec 4;238(4832):1403-6
references.pmid: 3317832
references.citation: Cell. 1997 Nov 28;91(5):705-12
references.pmid: 9393863
references.citation: Biochemistry. 1969 Jul;8(7):2897-905
references.pmid: 4897206
references.citation: Cold Spring Harb Symp Quant Biol. 2001;66:607-14
references.pmid: 12762062
references.citation: Nature. 2000 Sep 21;407(6802):327-39
references.pmid: 11014182
references.citation: J Mol Biol. 2006 Jul 21;360(4):893-906
references.pmid: 16784753
references.citation: Proc Natl Acad Sci U S A. 1967 May;57(5):1294-301
references.pmid: 5341237
references.citation: J Mol Biol. 2009 May 29;389(1):146-56
references.pmid: 19362093
references.citation: J Mol Biol. 1988 Mar 5;200(1):65-87
references.pmid: 3288761
references.citation: Nature. 1968 Jan 13;217(5124):130-4
references.pmid: 23610788
references.citation: Science. 2011 Feb 11;331(6018):730-6
references.pmid: 21205638
references.citation: Proc Natl Acad Sci U S A. 1968 Mar;59(3):777-84
references.pmid: 4868216
references.citation: J Mol Biol. 1964 Nov;10:319-36
references.pmid: 14235590
references.citation: Curr Opin Struct Biol. 2007 Jun;17(3):302-9
references.pmid: 17574829
references.citation: Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2023-8
references.pmid: 10696113
references.citation: Proc Natl Acad Sci U S A. 1961 Jan 15;47:18-23
references.pmid: 13782837
references.citation: Biochem Cell Biol. 1995 Nov-Dec;73(11-12):757-65
references.pmid: 8721992
references.citation: J Mol Biol. 1970 Sep 14;52(2):355-69
references.pmid: 5485914
references.citation: EMBO J. 1994 Aug 15;13(16):3661-8
references.pmid: 8070396
references.citation: Proc Natl Acad Sci U S A. 1972 Aug;69(8):1997-9
references.pmid: 4506067
references.citation: Cell. 2000 Sep 1;102(5):615-23
references.pmid: 11007480
references.citation: EMBO J. 1994 Aug 15;13(16):3669-77
references.pmid: 8070397
references.citation: J Mol Biol. 2003 Jul 25;330(5):1061-75
references.pmid: 12860128
references.citation: Mol Gen Genet. 1975 Oct 3;140(3):253-74
references.pmid: 1107798
references.citation: J Mol Biol. 2000 Aug 11;301(2):401-14
references.pmid: 10926517
references.citation: J Mol Biol. 1991 Nov 5;222(1):11-5
references.pmid: 1942063
references.citation: RNA. 2000 Aug;6(8):1091-105
references.pmid: 10943889
references.citation: Science. 2000 Aug 11;289(5481):920-30
references.pmid: 10937990
references.citation: J Mol Biol. 1983 Dec 5;171(2):207-15
references.pmid: 6197527
references.citation: Cell. 1998 Jun 26;93(7):1105-15
references.pmid: 9657144
references.citation: J Mol Biol. 2008 Jun 6;379(3):505-19
references.pmid: 18455733
references.citation: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13436-41
references.pmid: 9811818
references.citation: Annu Rev Biophys. 2012;41:1-19
references.pmid: 22577819
references.citation: Nat Struct Biol. 2002 Mar;9(3):225-30
references.pmid: 11828326
references.citation: Science. 1995 Dec 1;270(5241):1464-72
references.pmid: 7491491
references.citation: RNA. 2003 Jan;9(1):44-51
references.pmid: 12554875
references.citation: FEBS Lett. 1983 Mar 7;153(1):199-203
references.pmid: 6186533