title: Staying alive: defensive strategies in the BCL-2 family playbook.
abstract: Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhibition that exhibit surprisingly different behavior upon repeat proapoptotic challenges by BH3-only proteins.
authors.affiliation: Science Foundation Ireland, Laboratory for Molecular Cell Biology, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Cullen
authors.forename: Conor M
authors.initials: CM
authors.lastname: Henry
authors.forename: Seamus J
authors.initials: SJ
authors.lastname: Martin