title: Spleen in haematological malignancies: spectrum of imaging findings.
abstract: Imaging morphology and metabolic activity of splenic lesions is of paramount importance in patients with haematological malignancies; it can alter tumour staging, treatment protocols and overall prognosis. CT, MRI and positron emission tomography (PET)/CT have been shown to be powerful tools for the non-invasive assessment of splenic involvement in various haematological malignancies. Since many haematological malignancies and non-neoplastic conditions can involve the spleen and imaging manifestations can overlap, imaging and clinical findings outside of the spleen should be looked for to narrow the differential diagnosis; confirmation can be obtained by pathological findings. Radiologists should be familiar with the cross-sectional imaging patterns of haematological malignancies involving the spleen as well as non-neoplastic splenic findings common in these patients to facilitate their care and follow-up. This pictorial review provides the common and uncommon imaging appearances and complications of various haematological malignancies involving the spleen on CT, MRI and PET/CT, and common pitfalls in diagnosis.
authors.affiliation: Department of Radiology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. ssaboo@partners.org
authors.forename: S S
authors.initials: SS
authors.lastname: Saboo
authors.forename: K M
authors.initials: KM
authors.lastname: Krajewski
authors.forename: K N
authors.initials: KN
authors.lastname: O'Regan
authors.forename: A
authors.initials: A
authors.lastname: Giardino
authors.forename: J R
authors.initials: JR
authors.lastname: Brown
authors.forename: N
authors.initials: N
authors.lastname: Ramaiya
authors.forename: J P
authors.initials: JP
authors.lastname: Jagannathan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D013160:Splenic Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
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