title: Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents.
abstract: A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00μg/ml) against Mycobacteriumtuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0μg/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl) benzothiazole showed MIC of 1.5μg/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs.
authors.affiliation: Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, India. vikastelvekar@rediffmail.com
authors.forename: Vikas N
authors.initials: VN
authors.lastname: Telvekar
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Bairwa
authors.forename: Kalpana
authors.initials: K
authors.lastname: Satardekar
authors.forename: Anirudh
authors.initials: A
authors.lastname: Bellubi
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D052160:Benzothiazoles / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009161:Mycobacterium / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D013055:Spectrophotometry, Infrared / Q000379:methods; D013329:Structure-Activity Relationship; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D052160:Benzothiazoles; D006834:Hydrazines