title: Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model.
abstract: In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the renewal of osteoclast nuclei by cell fusion. All these features are shown to strongly influence the geometrical properties of the developing resorption cavity including its size, shape and progression rate, and are also shown to influence the distribution, resorption pattern and trajectories of individual osteoclasts within the BMU. We demonstrate that for certain parameter combinations, resorption cavity shapes can be recovered from the computational model that closely resemble resorption cavity shapes observed from microCT imaging of human cortical bone.
authors.affiliation: Faculty of Engineering, Computing and Mathematics, The University of Western Australia, WA 6009, Australia. pascal.buenzli@uwa.edu.au
authors.forename: Pascal R
authors.initials: PR
authors.lastname: Buenzli
authors.forename: Junhwan
authors.initials: J
authors.lastname: Jeon
authors.forename: Peter
authors.initials: P
authors.lastname: Pivonka
authors.forename: David W
authors.initials: DW
authors.lastname: Smith
authors.forename: Peter T
authors.initials: PT
authors.lastname: Cummings
mesh_terms: D001857:Bone Matrix / Q000378:metabolism / Q000648:ultrastructure; D016723:Bone Remodeling; D001862:Bone Resorption / Q000378:metabolism*; D002450:Cell Communication; D002465:Cell Movement; D003198:Computer Simulation; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000502:physiology*; D055114:X-Ray Microtomography
references.citation: Calcif Tissue Int. 1999 Oct;65(4):280-4
references.pmid: 10485978
references.citation: Eur J Morphol. 2002 Dec;40(5):309-15
references.pmid: 15101447
references.citation: Bone. 2009 Jul;45(1):77-83
references.pmid: 19303955
references.citation: J Biomech. 2003 Oct;36(10):1453-9
references.pmid: 14499294
references.citation: J Bone Miner Res. 2009 May;24(5):860-70
references.pmid: 19063683
references.citation: Biophys J. 2010 Jan 6;98(1):37-47
references.pmid: 20074513
references.citation: Biosystems. 2004 Aug-Oct;76(1-3):89-100
references.pmid: 15351133
references.citation: Calcif Tissue Int. 2006 Apr;78(4):241-7
references.pmid: 16604282
references.citation: Anat Rec. 1991 Nov;231(3):298-315
references.pmid: 1662472
references.citation: Phys Rev Lett. 2007 Jul 6;99(1):010602
references.pmid: 17678144
references.citation: Calcif Tissue Int. 1991 Aug;49(2):65-70
references.pmid: 1913296
references.citation: J Math Biol. 1988;26(3):263-98
references.pmid: 3411255
references.citation: J Cell Biochem. 1994 Jul;55(3):273-86
references.pmid: 7962158
references.citation: Bone Miner. 1988 Oct;5(1):1-9
references.pmid: 3214678
references.citation: Bone. 2011 Apr 1;48(4):918-26
references.pmid: 21172465
references.citation: Phys Rev Lett. 2007 Dec 14;99(24):248101
references.pmid: 18233492
references.citation: Physica A. 2007 Jan 1;373:521-532
references.pmid: 18167520
references.citation: J Cell Sci. 1987 Mar;87 ( Pt 2):241-8
references.pmid: 3654786
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul;288(7):806-16
references.pmid: 16761291
references.citation: J Theor Biol. 2002 Dec 7;219(3):343-70
references.pmid: 12419662
references.citation: Cell. 2006 Dec 1;127(5):905-15
references.pmid: 17129778
references.citation: Bone. 2008 Feb;42(2):250-9
references.pmid: 18063436
references.citation: J Math Biol. 2009 Apr;58(4-5):545-59
references.pmid: 18787828
references.citation: J Transl Med. 2004 Mar 16;2(1):6
references.pmid: 15025786
references.citation: Bone. 1998 Dec;23(6):491-4
references.pmid: 9855456
references.citation: Bone. 1994 Sep-Oct;15(5):547-9
references.pmid: 7526879
references.citation: Calcif Tissue Int. 1979 Aug 24;28(1):1-5
references.pmid: 115547
references.citation: J Bone Miner Res. 1996 Sep;11(9):1281-91
references.pmid: 8864903
references.citation: Am J Anat. 1981 Sep;162(1):35-43
references.pmid: 7304473
references.citation: J Musculoskelet Neuronal Interact. 2004 Sep;4(3):243-53
references.pmid: 15615492
references.citation: Phys Rev Lett. 1996 Apr 15;76(16):3032-3035
references.pmid: 10060853
references.citation: J Bone Miner Res. 1987 Dec;2(6):595-610
references.pmid: 3455637
references.citation: Bone. 2008 Sep;43(3):476-82
references.pmid: 18619937
references.citation: Calcif Tissue Res. 1969;3(3):211-37
references.pmid: 4894738
references.citation: J Anat. 1981 Oct;133(Pt 3):397-405
references.pmid: 7328046
references.citation: Biomech Model Mechanobiol. 2005 Nov;4(2-3):147-67
references.pmid: 15942795
references.citation: Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Mar;47(3):2128-2154
references.pmid: 9960234
references.citation: J Theor Biol. 2007 Jun 21;246(4):583-603
references.pmid: 17374383
references.citation: Phys Biol. 2005 Jul 12;2(3):133-47
references.pmid: 16224119
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9467-71
references.pmid: 10944216
references.citation: Am J Anat. 1977 Jul;149(3):301-17
references.pmid: 879049
references.citation: J Bone Miner Res. 2002 Jan;17(1):77-90
references.pmid: 11771672
references.citation: Annu Rev Biomed Eng. 2006;8:455-98
references.pmid: 16834564
references.citation: J Biomed Mater Res. 1998 Nov;42(2):278-85
references.pmid: 9773824
references.citation: Exp Hematol. 1999 Aug;27(8):1229-41
references.pmid: 10428500
references.citation: Cell Tissue Res. 1985;241(3):671-5
references.pmid: 2992797
references.citation: Clin Orthop Relat Res. 1980 Jun;(149):268-82
references.pmid: 7408312
references.citation: Metab Bone Dis Relat Res. 1983;4(5):281-90
references.pmid: 6353132
references.citation: Endocr Rev. 2000 Apr;21(2):115-37
references.pmid: 10782361
references.citation: J Bone Miner Res. 1996 Feb;11(2):150-9
references.pmid: 8822338
references.citation: J Bone Joint Surg Am. 1958 Apr;40-A(2):419-34
references.pmid: 13539066
references.citation: Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Jun;49(6):5462-5471
references.pmid: 9961873