title: Keratocystic odontogenic tumour (KCOT)--a cyst to a tumour.
abstract: OBJECTIVE
  The World Health Organization (WHO) has reclassified 'odontogenic keratocyst' (OKC) to 'keratocystic odontogenic tumour' (KCOT) in 2005. Currently, this tumour is classified as a benign neoplasm of odontogenic origin and not as a cyst. This article reviews and discusses history, classification scheme, aetiology and pathogenesis, molecular and genetic basis, incidence, epidemiology and site, clinical features, imaging, histopathology, immunohistochemistry, treatment options, prognosis, recurrence and malignant transformation of KCOT, with emphasis on understanding the basis of reclassification as 'keratocystic odontogenic tumour'.
  
  
  METHODS
  A systematic search and review of the literature was carried out in the online database of the United States National Library of Medicine to identify eligible titles for the study.
  
  
  RESULTS
  Current evidence suggests that the scientific community still continues to use the term 'odontogenic keratocyst' more favourably than 'keratocystic odontogenic tumour'.
  
  
  CONCLUSIONS
  The online database search indicates that the scientific community still continues to use the term 'odontogenic keratocyst' more favourably than 'keratocystic odontogenic tumour'. At this juncture, where the terminology has changed from a cyst to a tumour, a thorough review of literature on KCOT is presented.
authors.affiliation: Smile Mechanics-Centre for Maxillofacial Surgery & Dental Implantology, H-3/2, B.D.A. Colony, Nayapura, Lalghati, Airport Road, Bhopal, Madhya Pradesh, 462032, India. emaildarpan@gmail.com
authors.forename: Darpan
authors.initials: D
authors.lastname: Bhargava
authors.forename: Ashwini
authors.initials: A
authors.lastname: Deshpande
authors.forename: M Anthony
authors.initials: MA
authors.lastname: Pogrel
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D003430:Cross-Sectional Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics; D008334:Mandible / Q000473:pathology; D008336:Mandibular Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008339:Mandibular Neoplasms / Q000473:pathology; D008437:Maxilla / Q000473:pathology; D008439:Maxillary Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008441:Maxillary Neoplasms / Q000473:pathology; D009807:Odontogenic Cysts / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D000072079:Patched Receptors; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics; D011862:Radiography, Panoramic; D011956:Receptors, Cell Surface / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D012008:Recurrence; D000072086:Smoothened Receptor; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D019394:Ki-67 Antigen; D000072079:Patched Receptors; D018809:Proliferating Cell Nuclear Antigen; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C491023:SMO protein, human; D000072086:Smoothened Receptor; D016159:Tumor Suppressor Protein p53
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