title: Does radioiodine therapy in patients with differentiated thyroid cancer increase the frequency of another malignant neoplasm?
abstract: Objectives. To compare the frequency of another primary malignancy in patients with differentiated thyroid carcinoma (DTC) who received radioiodine therapy or not ((131)I). Material and Methods. 168 cases of DTC patients were retrospectively evaluated as to the frequency of another neoplasia by comparing patients with and without it, taking into account clinical, laboratory, and therapeutic parameters. Results. Another primary malignancy occurred in 8.9% of patients. Of these, 53.3% showed the malignancy before (131)I and 46.7% after it. By comparing both groups, the age at the moment of diagnosis of another neoplasia was 46.1 ± 20.2 years for the group before (131)I therapy and of 69.4 ± 11.4 years for the group after it (P = 0.02). Of the 148 patients treated with (131)I, 4.7% developed another malignancy. The latter were older (61 ± 17 years) than those who did not show another cancer type (44.1 ± 14.2 years) (P < 0.05). Conclusion. The frequency of another neoplasia found after (131)I was similar to that found before (131)I.
authors.affiliation: Departamento de Clinica Medica, Faculdade de Medicina (FMB), UNESP, Rubiao Junior s/n, Botucatu, 18618-000 São Paulo, Brazil.
authors.forename: Renata Midori
authors.initials: RM
authors.lastname: Hirosawa
authors.forename: Monica
authors.initials: M
authors.lastname: Marivo
authors.forename: Juliana de Moura Leite
authors.initials: Jde M
authors.lastname: Luengo
authors.forename: Jose Vicente
authors.initials: JV
authors.lastname: Tagliarini
authors.forename: Emanuel Cellice
authors.initials: EC
authors.lastname: Castilho
authors.forename: Mariangela de Alencar
authors.initials: Mde A
authors.lastname: Marques
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kiy
authors.forename: Marilia Martins Silveira
authors.initials: MM
authors.lastname: Marone
authors.forename: Liciana Vaz de Arruda
authors.initials: LV
authors.lastname: Silveira
authors.forename: Glaucia Maria Ferreira da Silva
authors.initials: GM
authors.lastname: Mazeto
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