title: Clinical implications of microRNAs in lung cancer.
abstract: Lung cancer still represents a very deadly disease in strong need of new, effective, therapeutic approaches. MicroRNAs (miRNAs) represent a new category of noncoding RNAs with gene expression regulatory functions. Several studies have shown that miRNAs are frequently deregulated in lung cancer patients with respect to healthy individuals. These aberrations of the miRNome (defined as the full spectrum of miRNAs in a given genome) occur at several levels, including primary tumors and patient body fluids (such as blood and sputum), suggesting that miRNAs can be effectively used as biological markers with diagnostic, prognostic, and predictive implications. This review focuses on these translational aspects of research on the field of miRNAs and lung cancer.
authors.affiliation: Gene Therapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Fanini
authors.forename: Ivan
authors.initials: I
authors.lastname: Vannini
authors.forename: Dino
authors.initials: D
authors.lastname: Amadori
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs