title: Lyell syndrome due to ticlopidine.
abstract: The antiplatelets drug ticlopidine is widely used in patients suffering from cardiomyopathies, coronary cardiopathies and thromboembolic pathologies. The potential and frequently seen side effects are diarrhoea, hematological dyscrasias and rashes. We describe a case in which the use of ticlopidine in the treatment and prophylaxis of transit ischemic attacks triggered the unusual and rare complication of toxic epidermal necrolysis (TEN). We will then go on to analyse the clinical-pathological aspects and therapies through the use of i.v. immunoglobulins at high dosages that led to a full recovery of the patient.
authors.affiliation: Department of Dermatology, Lecco Hospital, Lecco, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Strippoli
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: V
authors.initials: V
authors.lastname: Simonetti
authors.forename: A
authors.initials: A
authors.lastname: Motolese
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D013988:Ticlopidine / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine