title: The role of microRNAs in the biology of rare diseases.
abstract: Rare diseases (RD) are characterized by low prevalence and affect not more than five individuals per 10,000 in the European population; they are a large and heterogeneous group of disorders including more than 7,000 conditions and often involve all organs and tissues, with several clinical subtypes within the same disease. Very often information concerning either diagnosis and/or prognosis on many RD is insufficient. microRNAs are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level by either degrading or blocking translation of messenger RNA targets. Recently, microRNA expression patterns of body fluids underscored their potential as noninvasive biomarkers for various diseases. The role of microRNAs as potential biomarkers has become particularly attractive. The identification of disease-related microRNAs is essential for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. Computational analysis of microRNA-disease associations is an important complementary means for prioritizing microRNAs for further experimental examination. In this article, we explored the added value of miRs as biomarkers in a selected panel of RD hitting different tissues/systems at different life stages, but sharing the need of better biomarkers for diagnostic and prognostic purposes.
authors.affiliation: National Centre for Rare Diseases, Istituto Superiore di Sanità Viale Regina Elena, Rome 299-00161, Italy; E-Mails:  marco.salvatore@iss.it  (M.S.);  armando.magrelli@iss.it  (A.M.).
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Armando
authors.initials: A
authors.lastname: Magrelli
authors.forename: Domenica
authors.initials: D
authors.lastname: Taruscio
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D005097:Exostoses, Multiple Hereditary / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D018197:Hepatoblastoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D020388:Muscular Dystrophy, Duchenne / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D016506:Pemphigus, Benign Familial / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D035583:Rare Diseases / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D015518:Rett Syndrome / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D012751:Sezary Syndrome / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
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