title: A shared structural solution for neutralizing ebolaviruses.
abstract: Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step--probably fusion.
authors.affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
authors.forename: João M
authors.initials: JM
authors.lastname: Dias
authors.forename: Ana I
authors.initials: AI
authors.lastname: Kuehne
authors.forename: Dafna M
authors.initials: DM
authors.lastname: Abelson
authors.forename: Shridhar
authors.initials: S
authors.lastname: Bale
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Wong
authors.forename: Peter
authors.initials: P
authors.lastname: Halfmann
authors.forename: Majidat A
authors.initials: MA
authors.lastname: Muhammad
authors.forename: Marnie L
authors.initials: ML
authors.lastname: Fusco
authors.forename: Samantha E
authors.initials: SE
authors.lastname: Zak
authors.forename: Eugene
authors.initials: E
authors.lastname: Kang
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
authors.forename: Kartik
authors.initials: K
authors.lastname: Chandran
authors.forename: John M
authors.initials: JM
authors.lastname: Dye
authors.forename: Erica Ollmann
authors.initials: EO
authors.lastname: Saphire
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000502:physiology; D057134:Antibodies, Neutralizing / Q000737:chemistry* / Q000502:physiology; D018360:Crystallography, X-Ray; D029043:Ebolavirus / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D018448:Models, Immunological; D008958:Models, Molecular; D009500:Neutralization Tests; D017434:Protein Structure, Tertiary; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000276:immunology* / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000939:Epitopes; D014760:Viral Fusion Proteins
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