title: Effects of ultraviolet radiation exposure on FOXP3+ infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma.
abstract: OBJECTIVE
  To analyze the prevalence and significance of FOXP3+ infiltration into (pre)malignant skin carcinomas following ultraviolet radiation (UVR) exposure. The possible pathways that UVR impacts on FOXP3 are to be discussed.
  
  
  BACKGROUND
  FOXP3+ regulatory T cells (FOXP3+ Tregs) are correlated to cutaneous squamous tumor progression. However, there is no information describing the prevalence of FOXP3+ infiltration in cutaneous premalignant and malignant squamous carcinomas with UVR exposure.
  
  
  METHODS
  We investigated the prevalence of FOXP3+ infiltration in 14 patients with Bowen's disease, 40 squamous cell carcinoma SCC patients and 21 patients with basal cell carcinoma (BCC) by immunohistochemistry.
  
  
  RESULTS
  The percentages of FOXP3+ vs. total peri-neoplasm infiltration cells (FOXP3+ PCT) were significantly higher in Bowen's disease and well-differentiated SCC that were exposed to UVR than these diseases not exposed to UVR (t = 3.5776, P = 0.0038; t' = 5.9214, P < 0.01, respectively). FOXP3+ PCT was also higher in less pigmented than pigmented sites in BCC (t = 3.369, P = 0.0032).
  
  
  CONCLUSIONS
  This study shed some light on the effect of UVR on FOXP3+ infiltration in skin (pre)malignant carcinomas. Our data suggested that FOXP3+ infiltration was positively related to UVR exposure. The mechanisms merit further investigation.
authors.affiliation: Department of Dermatology, Institute of Battle Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. chenling516@gmail.com
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Zhu
authors.initials: Z
authors.lastname: Shen
authors.forename: Jinjin
authors.initials: J
authors.lastname: Wu
mesh_terms: D001913:Bowen's Disease / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D002280:Basal Cell Carcinoma / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D002465:Cell Movement / Q000276:immunology / Q000528:radiation effects; D005260:Female; D051858:Forkhead Transcription Factors; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology; D014467:Ultraviolet Therapy
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors