title: Effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial.
abstract: BACKGROUND
  Due to enhanced fat storage primarily during the mid-pregnancy period, pregnancy is associated with elevated levels of lipid profiles. To our knowledge, no reports are available indicating the effects of probiotic yoghurt consumption on serum lipid profiles in pregnant women.
  
  
  OBJECTIVE
  This study was designed to determine the effects of daily consumption of probiotic yoghurt on lipid profiles of Iranian pregnant women.
  
  
  METHODS
  This randomized single-blinded controlled clinical trial was performed among 70 pregnant women, primigravida, aged 18-30 years old who were carrying singleton pregnancy at their third trimester. Subjects were randomly assigned to consume 200 g/d of conventional (n=33) or the probiotic group (n=37) for 9 weeks. The probiotic yoghurt was a commercially available product prepared with the starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus, enriched with probiotic culture of two strains of lactobacilli (Lactobacillus acidophilus LA5) and bifidobacteria (Bifidobacterium animalis BB12) with a total of min 1 × 10(7) colony-forming units. The conventional yoghurt contained the starter cultures of S. thermophilus and L. bulgaricus. Fasting blood samples were taken at baseline and after 9-weeks intervention to measure serum lipid profiles.
  
  
  RESULTS
  Although consumption of probiotic yogurt for 9 weeks had been resulted in a significant reduction in serum total- (-53.7 mg/dL, p=0.001), LDL- (-35.2 mg/dL, p=0.006) and HDL-cholesterol levels (-9.8 mg/dL, p=0.002) as well as serum triglyceride concentrations (-42.8 mg/dL, p=0.029), no significant differences were found comparing probiotic and conventional yogurts in terms of their effect on serum lipid profiles. Within-Group differences in conventional yogurt group revealed a significant reduction in HDL-cholesterol levels (-8.4 mg/dL, p=0.005) and borderline significant reduction in serum total cholesterol concentrations (-21.6 mg/dL, p=0.08).
  
  
  CONCLUSIONS
  In conclusion, consumption of probiotic yogurt among pregnant women could not affect serum lipid profiles as compared to the conventional yogurt.
authors.affiliation: Department of Biochemistry and Nutrition, School of Medicine, Kashan University of Medical Sciences, Iran.
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
authors.forename: Mansoreh
authors.initials: M
authors.lastname: Samimi
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Tabasi
authors.forename: Parisa
authors.initials: P
authors.lastname: Talebian
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Azarbad
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hydarzadeh
authors.forename: Ahmad
authors.initials: A
authors.lastname: Esmaillzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D001644:Bifidobacterium / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D007779:Lactobacillus acidophilus / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D011247:Pregnancy / Q000097:blood / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000378:metabolism; D037841:Pregnant People; D019936:Probiotics / Q000008:administration & dosage* / Q000494:pharmacology*; D016037:Single-Blind Method; D015014:Yogurt; D055815:Young Adult
chemical_list: D008055:Lipids