title: Computed tomographic cholangiography in living liver transplant donors:  factors determining the degree of contrast enhancement.
abstract: OBJECTIVE
  To determine factors affecting liver and bile duct contrast enhancement during computed tomographic cholangiography (CTC) in living-donor transplant candidates.
  
  
  METHODS
  Forty-four candidates underwent preoperative triphasic CT followed by intravenous infusion of 20 mL of iodipamide for CTC. Body size indices and liver volume were correlated to parenchymal and biliary enhancement. Bile duct visibility was compared to duct enhancement.
  
  
  RESULTS
  Poorly visualized first- and second-order bile ducts demonstrated diminished enhancement (P < 0.015). Both CTC parenchymal and biliary enhancement correlated inversely with body surface area, height, and weight (P < 0.001); inverse correlation was also seen between liver volume and parenchymal enhancement (P < 0.001). A moderately positive correlation was noted between CTC biliary and parenchymal portal venous enhancement (r = 0.421; P = 0.004).
  
  
  CONCLUSIONS
  Computed tomographic cholangiography parenchymal and biliary enhancement diminishes with increased body size and liver volume, supporting a need for adjustable contrast dosing. Portal venous parenchymal enhancement may serve as a preinfusion indicator.
authors.affiliation: Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Fetzer
authors.forename: Alessandro
authors.initials: A
authors.lastname: Furlan
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Wang
authors.forename: Stamatis
authors.initials: S
authors.lastname: Kantartzis
authors.forename: Biatta
authors.initials: B
authors.lastname: Sholosh
authors.forename: Kyongtae T
authors.initials: KT
authors.lastname: Bae
mesh_terms: D000328:Adult; D049628:Body Size; D002758:Cholangiography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007458:Iodipamide / Q000008:administration & dosage*; D016014:Linear Models; D016031:Liver Transplantation / Q000000981:diagnostic imaging*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007458:Iodipamide