title: Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology.
abstract: Bone consists of type I collagen as a major protein with minor various matrix proteins. Type VI collagen is one of bone matrix proteins but its function is not known. We therefore examined the effects of type VI collagen deficiency on bone. 3D-μCT analysis revealed that type VI collagen deficiency reduced cancellous bone mass. Cortical bone mass was not affected. Type VI collagen deficiency distorted the shape of osteoblasts both in the cancellous bone and in the cambium layer of periosteal region. Furthermore, type VI collagen deficiency disorganized collagen arrangement. These data indicate that type VI collagen contributes to maintain bone mass.
authors.affiliation: Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Izu
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ezura
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Mizoguchi
authors.forename: Aya
authors.initials: A
authors.lastname: Kawamata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Nakashima
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Hayata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hemmi
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonaldo
authors.forename: Masaki
authors.initials: M
authors.lastname: Noda
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016723:Bone Remodeling / Q000235:genetics; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D024142:Collagen Type VI / Q000172:deficiency / Q000235:genetics* / Q000502:physiology; D005109:Extracellular Matrix / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008859:Microscopy, Polarization; D010006:Osteoblasts / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology; D055114:X-Ray Microtomography
chemical_list: D024142:Collagen Type VI