title: Measuring impulsivity in mice: the five-choice serial reaction time task.
abstract: BACKGROUND
  Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented.
  
  
  OBJECTIVE
  This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity.
  
  
  METHODS
  The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms.
  
  
  RESULTS
  Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable.
  
  
  CONCLUSIONS
  The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.
authors.affiliation: School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sanchez-Roige
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Peña-Oliver
authors.forename: David N
authors.initials: DN
authors.lastname: Stephens
mesh_terms: D000818:Animals; D001288:Attention / Q000187:drug effects / Q000502:physiology*; D002755:Choice Behavior / Q000187:drug effects*; D059329:Cholinergic Neurons / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology; D056726:Genetic Association Studies / Q000379:methods; D018698:Glutamic Acid / Q000502:physiology; D007175:Impulsive Behavior / Q000235:genetics / Q000523:psychology*; D051379:Mice; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012691:Serial Learning / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors
chemical_list: D018698:Glutamic Acid; D004298:Dopamine
references.citation: Behav Brain Res. 2010 Dec 25;214(2):216-24
references.pmid: 20580749
references.citation: Psychopharmacology (Berl). 1997 Oct;133(4):329-42
references.pmid: 9372531
references.citation: J Neurosci. 2004 Jul 28;24(30):6733-40
references.pmid: 15282276
references.citation: Neuropsychopharmacology. 2002 Jun;26(6):716-28
references.pmid: 12007742
references.citation: Neuron. 2011 Feb 24;69(4):680-94
references.pmid: 21338879
references.citation: Neuropsychopharmacology. 2004 May;29(5):891-900
references.pmid: 14970827
references.citation: Hum Mol Genet. 2007 Jul 15;16(14):1708-19
references.pmid: 17517691
references.citation: Psychopharmacology (Berl). 1999 Oct;146(4):348-61
references.pmid: 10550486
references.citation: Psychopharmacology (Berl). 2011 Oct;217(3):433-42
references.pmid: 21509502
references.citation: Neuron. 2008 Mar 13;57(5):705-18
references.pmid: 18341991
references.citation: Behav Brain Res. 1983 Sep;9(3):361-80
references.pmid: 6639741
references.citation: Neurobiol Aging. 2011 Jan;32(1):75-84
references.pmid: 19178986
references.citation: Psychopharmacology (Berl). 2002 Oct;163(3-4):362-80
references.pmid: 12373437
references.citation: Behav Brain Res. 2003 Jun 16;142(1-2):69-79
references.pmid: 12798267
references.citation: PLoS One. 2011 Mar 07;6(3):e17586
references.pmid: 21408181
references.citation: Behav Brain Res. 2006 Jun 30;170(2):197-203
references.pmid: 16616787
references.citation: Nat Protoc. 2008;3(5):759-67
references.pmid: 18451784
references.citation: BMC Biol. 2009 Jul 08;7:37
references.pmid: 19586522
references.citation: Drug Alcohol Depend. 2003 Dec 11;72(3):287-95
references.pmid: 14643946
references.citation: Neuropsychopharmacology. 2002 Nov;27(5):712-22
references.pmid: 12431846
references.citation: J Neurosci. 2011 Mar 2;31(9):3500-7
references.pmid: 21368062
references.citation: Eur J Neurosci. 1999 Aug;11(8):2813-23
references.pmid: 10457178
references.citation: Genes Brain Behav. 2012 Mar;11(2):137-46
references.pmid: 22142176
references.citation: J Neurosci. 2011 May 18;31(20):7264-74
references.pmid: 21593311
references.citation: Neurosci Biobehav Rev. 2010 Nov;35(2):303-14
references.pmid: 20227436
references.citation: Biochem Biophys Res Commun. 1999 Nov 30;265(3):630-5
references.pmid: 10600472
references.citation: Biol Psychiatry. 2007 Jun 15;61(12):1351-60
references.pmid: 17161381
references.citation: Neuroinformatics. 2003;1(4):343-57
references.pmid: 15043220
references.citation: Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3169-79
references.pmid: 18640918
references.citation: Neuron. 2000 Jan;25(1):239-52
references.pmid: 10707987
references.citation: Neurosci Biobehav Rev. 2004 Nov;28(7):771-84
references.pmid: 15555683
references.citation: Psychopharmacology (Berl). 2005 Apr;179(1):68-76
references.pmid: 15678361
references.citation: Behav Pharmacol. 1994 Feb;5(1):4-14
references.pmid: 11224246
references.citation: Physiol Behav. 2006 Dec 30;89(5):692-703
references.pmid: 16987534
references.citation: J Neurosci. 2010 Jul 7;30(27):9241-52
references.pmid: 20610759
references.citation: Ann N Y Acad Sci. 2007 Dec;1121:639-55
references.pmid: 17846162
references.citation: Brain Res. 2002 Sep 6;948(1-2):1-7
references.pmid: 12383949
references.citation: Cell Death Differ. 2004 Oct;11(10):1102-11
references.pmid: 15153940
references.citation: Trends Pharmacol Sci. 2008 Apr;29(4):192-9
references.pmid: 18304658
references.citation: J Neurosci. 2004 Jan 28;24(4):773-80
references.pmid: 14749421
references.citation: Behav Brain Res. 2001 Nov 1;125(1-2):215-27
references.pmid: 11682113
references.citation: Trends Cogn Sci. 2002 Sep 1;6(9):361
references.pmid: 12200169
references.citation: Biol Psychiatry. 2009 Aug 15;66(4):360-7
references.pmid: 19251250
references.citation: Curr Protoc Neurosci. 2005 May;Chapter 8:Unit 8.5H
references.pmid: 18428627
references.citation: Neuropsychopharmacology. 2011 Jan;36(1):3-25
references.pmid: 20668434
references.citation: Pharmacol Biochem Behav. 2008 Aug;90(2):250-60
references.pmid: 18272211
references.citation: Genes Brain Behav. 2009 Nov;8(8):817-28
references.pmid: 19751396
references.citation: Trends Cogn Sci. 2008 Jan;12(1):7-12
references.pmid: 18042423
references.citation: Psychopharmacology (Berl). 1997 Jul;132(2):107-24
references.pmid: 9266608
references.citation: Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:43-9
references.pmid: 8534423
references.citation: Genes Brain Behav. 2007 Aug;6(6):579-87
references.pmid: 17116168
references.citation: Eur J Neurosci. 2010 Jan;31(1):156-64
references.pmid: 20092561
references.citation: Pharmacol Biochem Behav. 2006 Mar;83(3):428-40
references.pmid: 16626795
references.citation: Behav Brain Res. 2001 Nov 1;125(1-2):189-93
references.pmid: 11682110
references.citation: Behav Brain Res. 2006 May 15;169(2):325-34
references.pmid: 16529827
references.citation: Trends Neurosci. 1999 Apr;22(4):173-9
references.pmid: 10203855
references.citation: Psychopharmacology (Berl). 2010 Feb;208(3):387-99
references.pmid: 19997843
references.citation: Behav Brain Res. 2009 Jan 23;196(2):310-6
references.pmid: 18940201
references.citation: J Neurosci. 1998 Apr 15;18(8):3023-34
references.pmid: 9526019
references.citation: Biol Psychiatry. 2010 Jul 1;68(1):5-16
references.pmid: 20488434
references.citation: Psychopharmacology (Berl). 2006 Dec;189(2):211-23
references.pmid: 17019565
references.citation: Development. 2006 Nov;133(22):4399-408
references.pmid: 17035295
references.citation: Psychopharmacology (Berl). 2009 Jul;204(4):679-92
references.pmid: 19263039
references.citation: Neuropsychopharmacology. 2007 May;32(5):1195-206
references.pmid: 17035931
references.citation: Psychopharmacology (Berl). 2007 Dec;195(2):223-34
references.pmid: 17673981
references.citation: Psychopharmacology (Berl). 2002 Jul;162(2):129-37
references.pmid: 12110990
references.citation: Biol Psychiatry. 2011 Sep 15;70(6):545-52
references.pmid: 21612768
references.citation: J Neurosci. 2005 Mar 2;25(9):2255-66
references.pmid: 15745951