title: [Myocardial protection of cardioplegic solution with Salvia miltiorrhizae in extracorporeal circulation of coronary artery bypass graft].
abstract: OBJECTIVE
  To observe the myocardial protection of cardioplegic solution with Salvia miltiorrhizae (SM) in extracorporeal circulation of coronary artery bypass graft (CABG) and to investigate the mechanisms of SM.
  
  
  METHODS
  30 patients who received CABG under extracorporeal circulation were randomly assigned to two groups, the observation group (15 cases) and the control group (15 cases). Patients in the observation group received the cardioplegic solution with SM and those in the control group received the cardioplegic solution without SM. The indices such as serum SOD activities, MDA contents, LDH, CK-MB, cTnl levels, the rate of heart reskip, activated coagulation time (ACT), the time of assisted respiration, and the days of in-hospital after operation were observed in the two groups pre-operation, post-operation, 6 h and 24 h post-operation, respectively.
  
  
  RESULTS
  When compared with the control group, MDA contents, LDH, CK-MB, cTnl levels were lower, SOD activities (all P<0.05) and heart re-skip rate (P>0.05) higher in the observation group. There was no statistical significance in the time of assisted respiration, the days of in-hospital, or ACT in the two groups (P>0.05).
  
  
  CONCLUSIONS
  The application of cardioplegic solution with SM in extracorporeal circulation of CABG showed obvious myocardial protection. It had better effects than the cardioplegic solution with no SM.
authors.affiliation: Fourth Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Ma
authors.forename: Shi-xiao
authors.initials: SX
authors.lastname: Sun
mesh_terms: D000368:Aged; D002314:Cardioplegic Solutions / Q000494:pharmacology / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D027561:Salvia miltiorrhiza
chemical_list: D002314:Cardioplegic Solutions; D004365:Drugs, Chinese Herbal