title: Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice.
abstract: Accumulating evidence has implicated neuropeptides in modulating recognition, learning and memory. However, to date, no study has investigated the effects of neuropeptide Trefoil factor 3 (TFF3) on the process of learning and memory. In the present study, we evaluated the acute effects of TFF3 administration (0.1 and 0.5mg/kg, i.p.) on the acquisition and retention of object recognition memory in mice. We found that TFF3 administration significantly enhanced both short-term and long-term memory during the retention test, conducted 90 min and 24h after training respectively. Remarkably, acute TFF3 administration transformed a learning event that would not normally result in long-term memory into an event retained for a long-term period and produced no effect on locomotor activity in mice. In conclusion, the present results provide an important role of TFF3 in improving object recognition memory and reserving it for a longer time, which suggests a potential therapeutic application for diseases with recognition and memory impairment.
authors.affiliation: Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China. shhsh001@bjmu.edu.cn
authors.forename: Hai-Shui
authors.initials: HS
authors.lastname: Shi
authors.forename: Xi
authors.initials: X
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.forename: Qing-Jun
authors.initials: QJ
authors.lastname: Guo
authors.forename: Xiang-Heng
authors.initials: XH
authors.lastname: Luo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000494:pharmacology*; D021641:Recognition, Psychology / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects*; D013997:Time Factors; D000071165:Trefoil Factor-3
chemical_list: D010455:Peptides; C082495:TFF3 protein, human; D000071165:Trefoil Factor-3