title: A natural compound induced cardiogenic differentiation of endogenous MSCs for repair of infarcted heart.
abstract: An intra-myocardial injection of a cardiogenic factor (cardiogenin) was reported to induce myocardial regeneration of exogenous mesenchymal stem cell (MSCs) origin. In this study, replacement of the dangerous intra-myocardial injection with a safe method and whether the endogenous MSCs contribute to the cardiogenin-mediated myocardial regeneration were investigated. Bone marrow transplantation with labeled MSCs was performed in rats, which were subsequently subject to a permanent ligation of left anterior descending coronary artery one week after the transplantation. The rats were then treated with the cardiogenin through oral administration for 2 weeks. We not only demonstrated the substantial therapeutic effects of cardiogenin on myocardial infarction through an oral administration, but also provided direct evidences that the bone marrow derived endogenous MSCs are the major cellular source of the regenerating myocardium. Preliminary mechanistic studies suggested that miR-9 and its target E-cadherin may be required for intercalated disc formation.
authors.affiliation: Laboratory of Innovative Medicine, Hong Kong.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Lin
authors.forename: Peng
authors.initials: P
authors.lastname: Peng
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.forename: Shihui
authors.initials: S
authors.lastname: Chen
authors.forename: Karen
authors.initials: K
authors.lastname: Li
authors.forename: Zhong Yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Ye Hua
authors.initials: YH
authors.lastname: Mo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004452:Echocardiography; D005786:Gene Expression Regulation; D031986:Geum / Q000737:chemistry; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000166:cytology*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000187:drug effects; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D014916:Whole-Body Irradiation
chemical_list: D015820:Cadherins; D010936:Plant Extracts; D012503:Saponins; C539477:cardiogenin