title: [The endoscopic and clinical features of Indigo Naturalis-associated ischemic lesions of colonic mucosa].
abstract: OBJECTIVE
  By analysing the clinical features of Indigo Naturalis-associated ischemic lesion of colon mucosa to improve the precautionary and therapeutic level of the disease.
  
  
  METHODS
  Thirteen patients diagnosed as Indigo Naturalis-associated ischemic lesion of colon mucosa in Peking University Third Hospital from 2005 to 2010 were reviewed. The endoscopic and clinical features were analysed.
  
  
  RESULTS
  The 13 patients with an average age of (60.6 ± 14.1) years old were prescribed Chinese traditional medicine containing Indigo Naturalis for psoriasis or idiopathic thrombocytopenic purpura (ITP). The ratio of males to females was 1:1.6. The typical manifestations were abdominal pain and bloody stool with watering diarrhea before bloody stool in 61.5% patients. Endoscopic and pathological characteristics were coincident with ischemic lesion and more like a chronic index. Vasodilatic medicine was effective and the average hemostatic time was (1.7 ± 0.8) days. The prognosis was well and no recurrence was found during 3 months follow-up.
  
  
  CONCLUSIONS
  Patients having psoriasis or ITP treated with Chinese traditional medicine containing Indigo Naturalis have an inclination to colon mucosa lesions, even ischemic lesion. Careful assessment and observation before prescribing are necessary in these patients.
authors.affiliation: Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Bao-jun
authors.initials: BJ
authors.lastname: Suo
authors.forename: Li-ya
authors.initials: LY
authors.lastname: Zhou
authors.forename: Shi-gang
authors.initials: SG
authors.lastname: Ding
authors.forename: Yu-min
authors.initials: YM
authors.lastname: Lü
authors.forename: Fang
authors.initials: F
authors.lastname: Gu
authors.forename: San-ren
authors.initials: SR
authors.lastname: Lin
authors.forename: Ya-an
authors.initials: YA
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D004724:Endoscopy; D005260:Female; D006801:Humans; D007203:Indigo Carmine; D007211:Indoles; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000473:pathology
chemical_list: D004365:Drugs, Chinese Herbal; D007211:Indoles; D007203:Indigo Carmine