title: Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.
abstract: OBJECTIVE
  To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd-M) and daughters of women who belong to a healthy comparison group (HCd).
  
  
  METHODS
  Descriptive and analytic study.
  
  
  METHODS
  Unit of endocrinology and reproductive medicine.
  
  
  METHODS
  Fifteen PCOSd+M, 23 PCOSd-M, and 35 HCd were studied at 2-3 months of age.
  
  
  METHODS
  A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).
  
  
  METHODS
  Differences in AMH levels between PCOSd+M, PCOSd-M and HCd.
  
  
  RESULTS
  AMH and peak E(2) concentrations were significantly higher in PCOSd-M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E(2) levels similar to those observed in HCd.
  
  
  CONCLUSIONS
  The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.
authors.affiliation: Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Crisosto
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: Manuel
authors.initials: M
authors.lastname: Maliqueo
authors.forename: Virginia
authors.initials: V
authors.lastname: Pérez
authors.forename: Amanda
authors.initials: A
authors.lastname: Ladrón de Guevara
authors.forename: Jessica
authors.initials: J
authors.lastname: Preisler
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D001724:Birth Weight; D016640:Diabetes, Gestational / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D017588:Hyperandrogenism / Q000453:epidemiology / Q000378:metabolism*; D006946:Hyperinsulinism / Q000453:epidemiology / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D016729:Leuprolide / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000378:metabolism / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000378:metabolism*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D007328:Insulin; D013739:Testosterone; D054304:Anti-Mullerian Hormone; D008687:Metformin; D016729:Leuprolide