title: Synthesis of polyester nanoparticles in miniemulsion obtained by radical ring-opening of BMDO and their potential as biodegradable drug carriers.
abstract: 5,6-Benzo-2-methylene-1,3-dioxepane (BMDO) is used to obtain degradable polymeric nanoparticles via a statistical free-radical copolymerization with MMA and styrene in direct miniemulsion. The nanoparticles are analyzed by means of IR, NMR, DLS, SEM, and TEM. They show excellent cellular uptake and drug delivery properties. The cellular uptake into HeLa cells of particles resulting from copolymerization of BMDO with styrene is drastically enhanced compared to pure polystyrene. As a model drug system, paclitaxel is incorporated in PBMDO particles and its release and the effect on HeLa cells is studied and compared to commercial drug formulations. It is found that a drug delivery system based on PBMDO shows an excellent pharmacological effect.
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany.
authors.forename: Joerg Max
authors.initials: JM
authors.lastname: Siebert
authors.forename: Daniela
authors.initials: D
authors.lastname: Baumann
authors.forename: Anke
authors.initials: A
authors.lastname: Zeller
authors.forename: Volker
authors.initials: V
authors.lastname: Mailänder
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis*; D004655:Emulsions / Q000737:chemistry; D006367:HeLa Cells; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D006801:Humans; D008049:Lipase / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis*; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001672:Biocompatible Materials; D004337:Drug Carriers; D004655:Emulsions; D006573:Heterocyclic Compounds, 1-Ring; D011091:Polyesters; D013343:Styrenes; D019904:Polymethyl Methacrylate; D008049:Lipase; D017239:Paclitaxel