title: No association between Parkinson disease alleles and the risk of melanoma.
abstract: BACKGROUND
  Recent data showed that melanoma was more common among patients with Parkinson disease than individuals without Parkinson disease and vice versa. It has been hypothesized that these two diseases may share common genetic and environmental risk factors.
  
  
  METHODS
  We evaluated the association between single-nucleotide polymorphisms (SNP) selected on the basis of recent genome-wide association studies (GWAS) on Parkinson disease risk and the risk of melanoma using 2,297 melanoma cases and 6,651 controls.
  
  
  RESULTS
  The Parkinson disease SNP rs156429 in the chromosome 7p15 region was nominally associated with melanoma risk with P value of 0.04, which was not significant after the Bonferroni correction for multiple comparisons. No association was observed between the remaining 31 Parkinson disease SNPs and the risk of melanoma. The genetic score based on the number of Parkinson disease risk allele was not associated with melanoma risk [OR for the highest genetic score quartile (30-35) vs. the lowest (15-20), 1.13, 95% confidence interval (CI), 0.47-2.70].
  
  
  CONCLUSIONS
  The Parkinson disease SNPs identified in published GWAS do not seem to play an important role in melanoma development.
  
  
  CONCLUSIONS
  The Parkinson disease susceptibility loci discovered by GWAS contribute little to the observed epidemiologic association between the Parkinson disease and melanoma.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Shasha
authors.initials: S
authors.lastname: Meng
authors.forename: Fengju
authors.initials: F
authors.lastname: Song
authors.forename: Honglei
authors.initials: H
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Lee
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
authors.forename: Abrar A
authors.initials: AA
authors.lastname: Qureshi
authors.forename: Jiali
authors.initials: J
authors.lastname: Han
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008545:Melanoma / Q000453:epidemiology* / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
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