title: Effect of rosmarinic and caffeic acids on inflammatory and nociception process in rats.
abstract: Rosmarinic acid is commonly found in species of the Boraginaceae and the subfamily Nepetoideae (Lamiaceae). It has a number of interesting biological activities, for example, antiviral, antibacterial, anti-inflammatory, and antioxidant. The aim of the present study was to investigate the effect of the i.p. administration of caffeic and rosmarinic acid (5 and 10 mg/kg) on anti-inflammatory and nociceptive response using carrageenan-induced pleurisy model and tail-flick assay in rats. The analysis of cells in the pleural exudates revealed a reduction of 66% of the number of leukocytes that migrated to the pleural cavity in the animals treated with 5 mg/kg caffeic acid, and of 92.9% for the animals treated with 10 mg/kg in comparison with the control group. These exudates showed a balanced distribution of polymorphonuclear (PMN) and mononuclear (MN) cells, differently from the control group, in which PMN cells were predominant. The analysis to tail-flick latency was increased in the group treated with 10 mg/kg caffeic acid characterizing a nociceptive response. While there was no difference between control group and animals treated with rosmarinic.
authors.affiliation: Departamento de Bioquímica, Universidade Federal de Pelotas, Campus Capão do Leão S/N Caixa Postal 354, 96010-900 Pelotas, RS, Brazil.
authors.forename: Giovana Duzzo
authors.initials: GD
authors.lastname: Gamaro
authors.forename: Edna
authors.initials: E
authors.lastname: Suyenaga
authors.forename: Milene
authors.initials: M
authors.lastname: Borsoi
authors.forename: Joice
authors.initials: J
authors.lastname: Lermen
authors.forename: Patrícia
authors.initials: P
authors.lastname: Pereira
authors.forename: Patrícia
authors.initials: P
authors.lastname: Ardenghi
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