title: European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. A subgroup analysis of the European Consortium of stem cell mobilization.
abstract: The effectiveness of the novel hematopoietic stem cell mobilizing agent plerixafor was evaluated in nationwide compassionate use programs in 13 European countries. A total of 580 poor mobilizers with non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) and multiple myeloma (MM) were enrolled. All patients received plerixafor plus granulocyte CSF with or without chemotherapy. Overall, the collection yield was significantly higher in MM patients (>2.0 × 10(6) CD34+ cells/kg: 81.6%; >5.0 × 10(6) CD34+ cells/kg: 32.0%) than in NHL patients (>2.0 × 10(6) CD34+ cells/kg: 64.8%; >5.0 × 10(6) CD34+ cells/kg: 12.6%; P<0.0001) and also significantly higher in HL patients (>2.0 × 10(6) CD34+ cells/kg: 81.5%; >5.0 × 10(6) CD34+ cells/kg: 22.2%) than in NHL patients (P=0.013). In a subgroup analysis, there were no significant differences in mobilization success comparing patients with diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. Our data emphasize the role of plerixafor in poor mobilizers, but further strategies to improve the apheresis yield especially in patients with NHL are required.
authors.affiliation: Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hübel
authors.forename: M M
authors.initials: MM
authors.lastname: Fresen
authors.forename: J F
authors.initials: JF
authors.lastname: Apperley
authors.forename: G W
authors.initials: GW
authors.lastname: Basak
authors.forename: K W
authors.initials: KW
authors.lastname: Douglas
authors.forename: I H
authors.initials: IH
authors.lastname: Gabriel
authors.forename: C
authors.initials: C
authors.lastname: Geraldes
authors.forename: O
authors.initials: O
authors.lastname: Jaksic
authors.forename: Z
authors.initials: Z
authors.lastname: Koristek
authors.forename: N
authors.initials: N
authors.lastname: Kröger
authors.forename: F
authors.initials: F
authors.lastname: Lanza
authors.forename: R M
authors.initials: RM
authors.lastname: Lemoli
authors.forename: G
authors.initials: G
authors.lastname: Mikala
authors.forename: D
authors.initials: D
authors.lastname: Selleslag
authors.forename: N
authors.initials: N
authors.lastname: Worel
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.forename: R F
authors.initials: RF
authors.lastname: Duarte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D001596:Benzylamines; D001781:Blood Component Removal / Q000379:methods; D002648:Child; D000080027:Cyclams; D005062:European Union; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006689:Hodgkin Disease / Q000097:blood / Q000628:therapy*; D006801:Humans; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000628:therapy*; D014184:Transplantation, Homologous
chemical_list: D019380:Anti-HIV Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor