title: Genome-wide analysis of yeast aging.
abstract: In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes. A number of screens have been performed looking for genes that modify secondary age-associated phenotypes such as stress resistance or growth rate. More recently, moderate-throughput methods for measuring replicative life span and high-throughput methods for measuring chronological life span have allowed for the first unbiased screens aimed at directly identifying genes involved in determining yeast longevity. In this chapter we discuss large-scale life span studies performed in yeast and their implications for research related to the basic biology of aging.
authors.affiliation: Department of Pathology and the Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195-7470, USA, lothos@uw.edu.
authors.forename: George L
authors.initials: GL
authors.lastname: Sutphin
authors.forename: Brady A
authors.initials: BA
authors.lastname: Olsen
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D002455:Cell Division; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D023281:Genomics / Q000379:methods; D005838:Genotype; D008136:Longevity / Q000235:genetics; D050296:Microbial Viability; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D029701:Saccharomyces cerevisiae Proteins