title: Critical neural substrates for correcting unexpected trajectory errors and learning from them.
abstract: Our proficiency at any skill is critically dependent on the ability to monitor our performance, correct errors and adapt subsequent movements so that errors are avoided in the future. In this study, we aimed to dissociate the neural substrates critical for correcting unexpected trajectory errors and learning to adapt future movements based on those errors. Twenty stroke patients with focal damage to frontal or parietal regions in the left or right brain hemispheres and 20 healthy controls performed a task in which a novel mapping between actual hand motion and its visual feedback was introduced. Only patients with frontal damage in the right hemisphere failed to correct for this discrepancy during the ongoing movement. However, these patients were able to adapt to the distortion such that their movement direction on subsequent trials improved. In contrast, only patients with parietal damage in the left hemisphere showed a clear deficit in movement adaptation, but not in online correction. Left frontal or right parietal damage did not adversely impact upon either process. Our findings thus identify, for the first time, distinct and lateralized neural substrates critical for correcting unexpected errors during ongoing movements and error-based movement adaptation.
authors.affiliation: NM VA Healthcare System, Research Service 151, 1501 San Pedro Dr SE, Albuquerque, NM 87108, USA. pkm117@psu.edu
authors.forename: Pratik K
authors.initials: PK
authors.lastname: Mutha
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sainburg
authors.forename: Kathleen Y
authors.initials: KY
authors.lastname: Haaland
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000368:Aged; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology*
references.citation: Nature. 2000 Feb 3;403(6769):544-9
references.pmid: 10676962
references.citation: J Neurophysiol. 2000 May;83(5):2661-75
references.pmid: 10805666
references.citation: Neural Netw. 1996 Nov;9(8):1265-1279
references.pmid: 12662535
references.citation: Curr Biol. 2001 Sep 18;11(18):R729-32
references.pmid: 11566114
references.citation: J Neurosci. 2006 Mar 1;26(9):2424-33
references.pmid: 16510720
references.citation: Brain. 1996 Aug;119 ( Pt 4):1183-98
references.pmid: 8813282
references.citation: Electroencephalogr Clin Neurophysiol. 1988 Dec;70(6):499-509
references.pmid: 2461284
references.citation: J Neurosci. 2011 May 11;31(19):6972-81
references.pmid: 21562259
references.citation: J Cogn Neurosci. 2006 Dec;18(12):1973-83
references.pmid: 17129185
references.citation: Curr Biol. 2010 Jul 27;20(14):1290-5
references.pmid: 20598886
references.citation: Cereb Cortex. 2011 Jul;21(7):1602-12
references.pmid: 21084453
references.citation: Neuropsychologia. 2009 May;47(6):1449-59
references.pmid: 18692079
references.citation: Neuroimage. 2003 Nov;20 Suppl 1:S89-100
references.pmid: 14597301
references.citation: Cereb Cortex. 2007 Dec;17(12):2972-9
references.pmid: 17389629
references.citation: J Neurosci. 2004 Nov 3;24(44):9971-6
references.pmid: 15525782
references.citation: Exp Brain Res. 2000 Jan;130(2):159-68
references.pmid: 10672469
references.citation: Brain. 2000 Nov;123 ( Pt 11):2306-13
references.pmid: 11050030
references.citation: Exp Brain Res. 2010 Oct;206(3):257-69
references.pmid: 20820760
references.citation: J Neurophysiol. 2003 Sep;90(3):1503-13
references.pmid: 12736237
references.citation: Neuropsychologia. 1998 Jan;36(1):11-24
references.pmid: 9533383
references.citation: Cereb Cortex. 2011 Aug;21(8):1761-70
references.pmid: 21139077
references.citation: J Neurophysiol. 2005 May;93(5):2809-21
references.pmid: 15625094
references.citation: Brain Res. 2009 Nov 17;1298:78-91
references.pmid: 19728993
references.citation: Adv Exp Med Biol. 2009;629:405-21
references.pmid: 19227512
references.citation: J Neurosci. 2006 Apr 5;26(14):3642-5
references.pmid: 16597717
references.citation: Nat Neurosci. 2000 Jul;3(7):729-36
references.pmid: 10862707
references.citation: Science. 2007 Mar 30;315(5820):1860-2
references.pmid: 17395832
references.citation: Nat Neurosci. 1999 Jun;2(6):563-7
references.pmid: 10448222
references.citation: J Neurophysiol. 2002 Nov;88(5):2408-21
references.pmid: 12424282
references.citation: PLoS Biol. 2007 Nov;5(11):e316
references.pmid: 18044990
references.citation: Science. 1997 Aug 8;277(5327):821-5
references.pmid: 9242612
references.citation: Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17751-6
references.pmid: 20876098
references.citation: J Cogn Neurosci. 2009 Dec;21(12):2263-75
references.pmid: 19199405
references.citation: Brain. 2004 May;127(Pt 5):1145-58
references.pmid: 15033898
references.citation: J Neurosci. 2009 Oct 7;29(40):12675-85
references.pmid: 19812342
references.citation: Nature. 1996 Oct 17;383(6601):618-21
references.pmid: 8857536
references.citation: Exp Brain Res. 2002 Jan;142(2):241-58
references.pmid: 11807578
references.citation: Neuropsychologia. 2009 Nov;47(13):2953-66
references.pmid: 19573544
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Brain Res. 2000 Jul 14;871(1):127-45
references.pmid: 10882792
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Scand J Rehabil Med. 1975;7(1):13-31
references.pmid: 1135616
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13240-5
references.pmid: 20622155
references.citation: Eur J Neurosci. 2008 Oct;28(8):1696-704
references.pmid: 18973586
references.citation: Neuropsychologia. 2010 Nov;48(13):3855-67
references.pmid: 20875439
references.citation: J Neurophysiol. 1999 Mar;81(3):1045-56
references.pmid: 10085332
references.citation: J Neurosci. 2005 Oct 26;25(43):9919-31
references.pmid: 16251440
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3843-6
references.pmid: 8632977
references.citation: Exp Brain Res. 2010 May;203(1):75-87
references.pmid: 20237773
references.citation: J Cogn Neurosci. 2004 May;16(4):621-36
references.pmid: 15165352
references.citation: J Neurosci. 2007 Apr 4;27(14):3743-52
references.pmid: 17409238
references.citation: Nat Neurosci. 2000 Nov;3 Suppl:1212-7
references.pmid: 11127840
references.citation: Brain. 2007 Aug;130(Pt 8):2146-58
references.pmid: 17626039
references.citation: J Neurosci. 2001 Apr 15;21(8):2919-28
references.pmid: 11306644
references.citation: J Neurophysiol. 2004 Feb;91(2):924-33
references.pmid: 14523069
references.citation: Cortex. 2007 Apr;43(3):411-23
references.pmid: 17533764
references.citation: Exp Brain Res. 2007 Mar;177(4):447-57
references.pmid: 16988818
references.citation: J Neurophysiol. 2007 Jul;98(1):54-62
references.pmid: 17507504
references.citation: Exp Brain Res. 2002 Oct;146(4):451-9
references.pmid: 12355273
references.citation: Exp Brain Res. 2007 Jun;179(4):551-61
references.pmid: 17171336