title: Imaging carotid body chemodectomas with ⁶⁸Ga-DOTA-NOC PET-CT.
abstract: OBJECTIVE
  The purpose of the present study was to evaluate the role of 68-gallium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-1-Nal3-octreotide ((68)Ga-DOTA-NOC) positron emission tomography CT (PET-CT) in carotid body chemodectomas (CBCs).
  
  
  METHODS
  5 patients with known CBCs (conventional imaging and angiography) were evaluated retrospectively (3 males, 2 females; mean age 36.6 years). All underwent PET-CT after injection of 148 MBq (4 mCi) of (68)Ga-DOTA-NOC.
  
  
  RESULTS
  At baseline there were four bilateral CBCs and one unilateral CBC with an additional glomus tympanicum and bilateral glomus jugulare tumour in these five patients. All these lesions showed intense uptake on (68)Ga-DOTA-NOC PET-CT. Apart from these known lesions, additional tumours were detected in three patients; glomus jugulare in one, aortic body tumour and multiple abdominal paragangliomas in another and unsuspected vertebral metastasis in the last. Overall it led to a change in management in 3 of the 5 patients (60%).
  
  
  CONCLUSIONS
  (68)Ga-DOTA-NOC PET-CT is a promising non-invasive imaging modality in the detection and characterisation of CBCs.
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: N
authors.initials: N
authors.lastname: Naswa
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: C
authors.initials: C
authors.lastname: Bal
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: R
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000328:Adult; D002345:Carotid Body Tumor / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D010236:Paraganglioma, Extra-Adrenal / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals
references.citation: J Nucl Med. 2007 Oct;48(10):1741-8
references.pmid: 17873136
references.citation: J Nucl Med. 1993 Jun;34(6):873-8
references.pmid: 8389841
references.citation: Chin Med J (Engl). 2010 Oct;123(20):2816-9
references.pmid: 21034589
references.citation: Ann Otol Rhinol Laryngol. 2001 Jan;110(1):36-40
references.pmid: 11201806
references.citation: Ann Vasc Surg. 1996 Sep;10(5):464-8
references.pmid: 8905066
references.citation: Eur J Nucl Med Mol Imaging. 2010 Jan;37(1):67-77
references.pmid: 19618183
references.citation: Oral Oncol. 2004 Jul;40(6):563-75
references.pmid: 15063383
references.citation: Ann Vasc Surg. 1993 Mar;7(2):140-4
references.pmid: 8518130
references.citation: Fam Cancer. 2005;4(1):61-8
references.pmid: 15883712
references.citation: Ann Surg. 1963 Apr;157:633-6
references.pmid: 13975591