title: Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia.
abstract: The galloylated cyanogenic glucosides based on prunasin (1-7), gallotannins (8-14), ellagitannins (15-17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H(2)O(2))-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. tanhp@frim.gov.my
authors.forename: Hooi Poay
authors.initials: HP
authors.lastname: Tan
authors.forename: Daniel Zin Hua
authors.initials: DZ
authors.lastname: Wong
authors.forename: Sui Kiong
authors.initials: SK
authors.lastname: Ling
authors.forename: Cheng Hock
authors.initials: CH
authors.lastname: Chuah
authors.forename: Habsah Abdul
authors.initials: HA
authors.lastname: Kadir
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000633:toxicity; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000494:pharmacology*
chemical_list: D005960:Glucosides; D047348:Hydrolyzable Tannins; D018696:Neuroprotective Agents; D006861:Hydrogen Peroxide