title: A new cap for kinetochore fibre minus ends.
abstract: In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.
authors.affiliation: Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.
authors.forename: Sabine
authors.initials: S
authors.lastname: Petry
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Vale
mesh_terms: D000818:Animals; D020090:Chromosome Segregation / Q000502:physiology*; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*; D020931:ran GTP-Binding Protein / Q000502:physiology*
chemical_list: C113292:MCRS1 protein, human; D009687:Nuclear Proteins; C120587:RAN protein, human; D016601:RNA-Binding Proteins; D020931:ran GTP-Binding Protein
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