title: Measurement of SUVmax plus ADCmin of the primary tumour is a predictor of prognosis in patients with cervical cancer.
abstract: OBJECTIVE
  The objectives of this study were to determine if measurements of the maximum standardized uptake value (SUVmax) by positron emission tomography/computed tomography and minimum apparent diffusion coefficient (ADCmin) by magnetic resonance imaging are correlated with the clinical characteristics and prognosis of primary cervical cancer.
  
  
  METHODS
  The correlations between biological parameters and prognosis and SUVmax and ADCmin of the primary tumour were determined in 66 patients with cervical cancer before radiotherapy or concurrent chemoradiotherapy.
  
  
  RESULTS
  There were significant correlations between SUVmax of the primary tumour and FIGO stage (p = 0.036), tumour maximum size (p = 0.018) and pelvic lymph node metastasis (p = 0.044). The median durations of disease-free survival (DFS) and overall survival (OS) were 16.1 and 19.2 months, respectively. The DFS and OS of patients exhibiting high SUVmax of the primary tumour were significantly lower than those of patients exhibiting low SUVmax of the primary tumour (p = 0.0171 and p = 0.0367). The OS of patients exhibiting low ADCmin of the primary tumour was significantly lower than that of patients exhibiting high ADCmin of the primary tumour (p = 0.0376). The DFS and OS of patients exhibiting high SUVmax together with low ADCmin of the primary tumour were significantly lower (p = 0.003 and p = 0.001). Multivariate analyses showed that high SUVmax together with low ADCmin of the primary tumour was an independent prognostic factor for both DFS (p = 0.0030) and OS (p = 0.0036).
  
  
  CONCLUSIONS
  High SUVmax together with low ADCmin of the primary tumour is an important predictive factor for identifying patients with cervical cancer who have a poor prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kika-ku, Okayama 700-8558, Japan. k-nakamu@cc.okayama-u.ac.jp
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ikuo
authors.initials: I
authors.lastname: Joja
authors.forename: Junichi
authors.initials: J
authors.lastname: Kodama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hongo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiramatsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004058:Diffusion; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
chemical_list: D019275:Radiopharmaceuticals
references.citation: Gynecol Oncol. 2001 Jul;82(1):17-21
references.pmid: 11426956
references.citation: AJNR Am J Neuroradiol. 2007 Oct;28(9):1693-9
references.pmid: 17885229
references.citation: J Epidemiol Biostat. 2001;6(1):7-43
references.pmid: 11385777
references.citation: Eur J Nucl Med. 1996 Oct;23(10):1372-7
references.pmid: 8781143
references.citation: Radiology. 2007 May;243(2):493-9
references.pmid: 17356177
references.citation: Radiographics. 2005 Jul-Aug;25(4):913-30
references.pmid: 16009815
references.citation: J Nucl Med. 1998 Oct;39(10):1727-35
references.pmid: 9776278
references.citation: Eur Radiol. 2005 Jan;15(1):71-8
references.pmid: 15538578
references.citation: Clin Cancer Res. 2000 Oct;6(10):3837-44
references.pmid: 11051227
references.citation: Gynecol Oncol. 2010 Oct;119(1):81-6
references.pmid: 20580064
references.citation: Am J Obstet Gynecol. 1987 Apr;156(4):988-96
references.pmid: 3578411
references.citation: Eur J Radiol. 2008 Jun;66(3):493-500
references.pmid: 18337039
references.citation: AJR Am J Roentgenol. 2001 Jun;176(6):1449-54
references.pmid: 11373212
references.citation: Radiology. 2003 Jan;226(1):71-8
references.pmid: 12511671
references.citation: Radiology. 2008 May;247(2):458-64
references.pmid: 18430878
references.citation: Nat Rev Cancer. 2002 Sep;2(9):683-93
references.pmid: 12209157
references.citation: Eur Radiol. 2008 May;18(5):1058-64
references.pmid: 18193428
references.citation: Eur J Obstet Gynecol Reprod Biol. 1987 Sep;26(1):69-84
references.pmid: 3311843
references.citation: Gynecol Oncol. 1981 Oct;12(2 Pt 1):154-65
references.pmid: 7297927
references.citation: AJR Am J Roentgenol. 2007 Jun;188(6):1622-35
references.pmid: 17515386
references.citation: Gynecol Oncol. 1989 Dec;35(3):314-20
references.pmid: 2599466
references.citation: Eur J Nucl Med Mol Imaging. 2002 Dec;29(12):1639-47
references.pmid: 12458399
references.citation: J Clin Oncol. 2002 Jan 15;20(2):379-87
references.pmid: 11786564
references.citation: Radiology. 2006 Dec;241(3):839-46
references.pmid: 17032910
references.citation: Int J Cancer. 2004 May 10;109(6):926-32
references.pmid: 15027127
references.citation: Eur J Nucl Med Mol Imaging. 2002 Oct;29(10):1317-23
references.pmid: 12271413
references.citation: Radiology. 2006 Jun;239(3):632-49
references.pmid: 16714455
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078
references.citation: AJNR Am J Neuroradiol. 2006 Aug;27(7):1419-25
references.pmid: 16908550
references.citation: Radiology. 2007 Dec;245(3):848-54
references.pmid: 17951348
references.citation: Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):4-5
references.pmid: 15093892
references.citation: Eur J Cardiothorac Surg. 2009 Apr;35(4):706-10; discussion 710-1
references.pmid: 19216085
references.citation: Radiology. 2002 Jul;224(1):177-83
references.pmid: 12091680
references.citation: Radiology. 2009 May;251(2):398-407
references.pmid: 19276322
references.citation: J Magn Reson Imaging. 2008 May;27(5):1109-13
references.pmid: 18425832
references.citation: NMR Biomed. 2009 Jan;22(1):104-13
references.pmid: 18384182
references.citation: Eur Radiol. 2006 Jul;16(7):1468-77
references.pmid: 16557366
references.citation: J Neuroradiol. 2007 Jul;34(3):183-9
references.pmid: 17568674
references.citation: Cancer. 2007 Oct 15;110(8):1738-44
references.pmid: 17786947
references.citation: Eur J Nucl Med Mol Imaging. 2009 Feb;36(2):200-8
references.pmid: 18779960