title: Neurovascular aspects of skin neurogenic inflammation.
abstract: Neurogenic inflammation is involved in skin inflammation. It is hypothesized that it is involved in the pathogenesis of the common chronic cutaneous vascular disorder rosacea, but the exact mechanism of action is currently unknown. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) are widely expressed on primary sensory neuron endings and non-neuronal cells such as keratinocytes. Here we describe the potential for TRPV1 and TRPA1 receptors to be involved in the pathophysiology of rosacea due to their polymodal activation, including cold and hot temperature, pungent products from vegetable and spices, reactive oxygen species, and mechanical stimuli. We discuss the role of both receptors and the sensory neuropeptides that they release in inflammation and pain sensation and evidence suggesting that both TRPV1 and TRPA1 receptors may be promising therapeutic targets for the treatment of the inflammatory symptoms of rosacea.
authors.affiliation: Cardiovascular Division and Centre for Integrative Biomedicine, BHF King's College London Cardiovascular Centre of Excellence, King's College London, Waterloo Campus, London, UK.
authors.forename: Aisah A
authors.initials: AA
authors.lastname: Aubdool
authors.forename: Susan D
authors.initials: SD
authors.lastname: Brain
mesh_terms: D000818:Animals; D017487:Ankyrins / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D003872:Dermatitis / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006801:Humans; D008297:Male; D051379:Mice; D020078:Neurogenic Inflammation / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology; D010447:Peptide Hydrolases / Q000502:physiology; D051381:Rats; D012393:Rosacea / Q000503:physiopathology*; D012737:Sex Factors; D012867:Skin / Q000098:blood supply* / Q000294:innervation*; D013373:Substance P / Q000502:physiology; D050916:TRPV Cation Channels / Q000502:physiology
chemical_list: D017487:Ankyrins; D050916:TRPV Cation Channels; D013373:Substance P; D010447:Peptide Hydrolases; D015740:Calcitonin Gene-Related Peptide