title: A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas.
abstract: A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2-5) from the gorgonian coral Junceellajuncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2-5) did not exhibit the activity against fungi.
authors.affiliation: Organic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam 530 003, India. murthyyln@yahoo.co.in
authors.forename: Y L N
authors.initials: YL
authors.lastname: Murthy
authors.forename: D
authors.initials: D
authors.lastname: Mallika
authors.forename: Abdul
authors.initials: A
authors.lastname: Rajack
authors.forename: G Damodar
authors.initials: GD
authors.lastname: Reddy
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation
chemical_list: C570590:11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide; D000935:Antifungal Agents; D004224:Diterpenes