title: Mcl-1 levels need not be lowered for cells to be sensitized for ABT-263/737-induced apoptosis.
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: G
authors.initials: G
authors.lastname: Perkins
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001713:Biphenyl Compounds / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051379:Mice; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009596:Nitrophenols / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: C501332:ABT-737; D000814:Aniline Compounds; D001713:Biphenyl Compounds; C579094:Mcl1 protein, mouse; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009596:Nitrophenols; D010879:Piperazines; D019253:Proto-Oncogene Proteins c-bcl-2; D013449:Sulfonamides; C528561:navitoclax
references.citation: Mol Cell. 2005 Feb 4;17(3):393-403
references.pmid: 15694340
references.citation: Cancer Cell. 2006 Nov;10(5):389-99
references.pmid: 17097561
references.citation: Oncogene. 2010 Mar 18;29(11):1641-52
references.pmid: 19966861
references.citation: Cell Death Differ. 2010 Aug;17(8):1335-44
references.pmid: 20203689
references.citation: Science. 2007 Feb 9;315(5813):856-9
references.pmid: 17289999
references.citation: PLoS One. 2011;6(9):e24102
references.pmid: 21949692
references.citation: Cancer Cell. 2006 Nov;10(5):375-88
references.pmid: 17097560
references.citation: Cancer Res. 2011 Aug 1;71(15):5204-13
references.pmid: 21670080