title: Determinants of progression of aortic valve stenosis and outcome of adverse events in hemodialysis patients.
abstract: BACKGROUND
  Hemodialysis (HD) is an important risk factor for progression of aortic valve stenosis (AS). However, there are varying degrees of disease progression among patients with AS on HD. The aim of this study was to find determinants of rapid progression of AS in patients on HD.
  
  
  METHODS
  We enrolled 30 patients with AS on HD with a mean follow-up period of 4 years. The peak pressure gradient (PPG) between the initial echocardiography and the last echocardiography at least 3 months interval (ΔPPG) was adopted as the indicator of AS progression. We divided the patients into two groups according to ΔPPG per year [rapid progression (ΔPPG>4.5 mmHg/year), slow progression (ΔPPG<4.5 mmHg/year)] and compared the clinical characteristics between the two groups.
  
  
  RESULTS
  Overall mean ΔPPG was 4.5 mmHg/year. Systolic blood pressure (SBP), serum calcium, and calcium-phosphate product were significantly higher in rapid progression group compared with slow progression group (p<0.05).
  
  
  CONCLUSIONS
  High systolic blood pressure, serum calcium, and calcium-phosphate product were associated with rapid progression of AS in patients on chronic HD.
authors.affiliation: Division of Cardiovascular Medicine, Department of Integrated Medicine I, Saitama Medical Center, Jichi Medical University, Omiya, Saitama, Japan.
authors.forename: Mizuho
authors.initials: M
authors.lastname: Hoshina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kubo
authors.forename: Nahoko
authors.initials: N
authors.lastname: Ikeda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Momomura
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D002130:Calcium Phosphates / Q000097:blood; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D006435:Renal Dialysis; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D002118:Calcium