title: Oxidative stresses and ageing.
abstract: Oxidative damage to cellular constituents has frequently been associated with aging in a wide range of organisms. The power of yeast genetics and biochemistry has provided the opportunity to analyse in some detail how reactive oxygen and nitrogen species arise in cells, how cells respond to the damage that these reactive species cause, and to begin to dissect how these species may be involved in the ageing process. This chapter reviews the major sources of reactive oxygen species that occur in yeast cells, the damage they cause and how cells sense and respond to this damage.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia, nshmay@gmail.com.
authors.forename: May T
authors.initials: MT
authors.lastname: Aung-Htut
authors.forename: Anita
authors.initials: A
authors.lastname: Ayer
authors.forename: Michael
authors.initials: M
authors.lastname: Breitenbach
authors.forename: Ian W
authors.initials: IW
authors.lastname: Dawes
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D059447:Cell Cycle Checkpoints; D004249:DNA Damage; D004798:Enzymes / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008136:Longevity; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013997:Time Factors; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D004798:Enzymes; D017382:Reactive Oxygen Species