title: Gastrointestinal hormones: uroguanylin-a new gut-derived weapon against obesity?
abstract: A recent report has identified uroguanylin as an endocrine signal that exerts a physiological role in energy homeostasis, adding another factor to the gut–brain axis. From a clinical point of view, several observations highlight the uroguanylin–guanylyl cyclase C pathway as a potential therapeutic target for the development of antiobesity drugs.
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
mesh_terms: D000818:Animals; D015195:Drug Design; D015507:Drugs, Investigational / Q000627:therapeutic use; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051379:Mice; D008954:Models, Biological; D045265:Natriuretic Peptides / Q000737:chemistry / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology
chemical_list: D015507:Drugs, Investigational; D005768:Gastrointestinal Hormones; D045265:Natriuretic Peptides; C084362:uroguanylin
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