title: Topography of cortical thinning areas associated with hippocampal atrophy (HA) in patients with Alzheimer's disease (AD).
abstract: Prior studies have shown that patients with AD have decreased functional or structural connectivity between the hippocampus and other brain areas. To the best of our knowledge, however, there have been no studies investigating the topography of cortical thinning areas and correlations with HA using surface based morphometry of three-dimensional (3D) T1-weighted magnetic resonance (MR) images. Cortical thickness was measured using SBM, and hippocampal volume was measured using an automated method, in 219 patients with AD and 54 subjects with no cognitive impairment (NCI). A partial correlation model was used in analysis of cortical thinning related to HA. Cortical thinning areas related to HA were found mostly within areas associated with polysynaptic or direct pathways of the hippocampus, a finding consistent with the disconnection hypothesis. Therefore, the cortical atrophy related to HA in patients with AD may represent disrupted cortical brain networks in connection with HA. However, since the topography of HA-related cortical thinning in groups with Clinical Dementia Ratings (CDR) of 0.5 and 1 corresponded to the stages I-II and III-IV of Braak and Braak staging, respectively, we could not exclude the possibility of the "concomitant hypothesis," i.e. that these areas are affected concomitantly with the hippocampus.
authors.affiliation: Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Irwon-dong Kangnam-ku, Seoul 135-710, Republic of Korea.
authors.forename: Geon Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jee Hoon
authors.initials: JH
authors.lastname: Roh
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Chi Hun
authors.initials: CH
authors.lastname: Kim
authors.forename: Kiho
authors.initials: K
authors.lastname: Im
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Anqi
authors.initials: A
authors.lastname: Qiu
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000473:pathology; D059906:Neuroimaging / Q000379:methods; D009929:Organ Size