title: On the origin of hematopoietic stem cells: progress and controversy.
abstract: Hematopoietic Stem Cells (HSCs) are responsible for the production and replenishment of all blood cell types during the entire life of an organism. Generated during embryonic development, HSCs transit through different anatomical niches where they will expand before colonizing in the bone marrow, where they will reside during adult life. Although the existence of HSCs has been known for more than fifty years and despite extensive research performed in different animal models, there is still uncertainty with respect to the precise origins of HSCs. We review the current knowledge on embryonic hematopoiesis and highlight the remaining questions regarding the anatomical and cellular identities of HSC precursors.
authors.affiliation: Erasmus University Medical Center, Department of Cell Biology, Erasmus Stem Cell Institute, 3000 CA, Rotterdam, The Netherlands.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Boisset
authors.forename: Catherine
authors.initials: C
authors.lastname: Robin
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000166:cytology; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008954:Models, Biological