title: Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies.
abstract: The aim of our meta-analysis was to assess the association between UGT1A7 polymorphisms and cancer risk. Case?control studies containing available polymorphic alleles (UGT1A7*1,*2,*3, and*4) and genotypes categorized according to enzymatic activity (High, Intermediate, and Low) were chosen to assess this association. Twenty-one case?control studies were identified. Meta-analysis indicated that UGT1A7 had a significant effect on cancer risk. In subgroup analysis, a significantly increased risk was associated with East Asians, hepatocellular cancer, and colorectal cancer. This meta-analysis suggested that there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.
authors.affiliation: Department of Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Jiangsu Province, China.
authors.forename: Pei-Hua
authors.initials: PH
authors.lastname: Lu
authors.forename: Min-Bin
authors.initials: MB
authors.lastname: Chen
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Wu
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Gu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Rong-Min
authors.initials: RM
authors.lastname: Gu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk
chemical_list: D014453:Glucuronosyltransferase; C107611:UDP-glucuronosyltransferase, UGT1A7