title: (111)In-pentetreotide SPET/CT in carcinoid tumours: is the role of hybrid systems advantageous in abdominal or thoracic lesions?
abstract: Our aim was to evaluate the different clinical value of (111)In-pentetreotide hybrid SPET/CT versus SPET alone in detecting carcinoid tumours located in the thoracic and abdominal region.  Twenty-four patients with carcinoid tumours histologically proven (13 of abdominal origin, 11 of thoracic origin) underwent (111)In-pentetreotide SPET/CT with hybrid system  (Millennium VG with Hawkeye, G.E.M.S., USA) composed of a dual head gamma camera equipped with a low dose X-ray tube. Single photon emission tomography images were  performed 4h and 24h after (111)In-pentetreotide intravenous administration, while SPET/CT co-registered images were performed at 4h. Scintigraphic images were first evaluated alone and  then re-interpreted by adding transmission fused data. Nine of the 13 patients with tumours of abdominal origin showed pathological SPET images, while 4/13 were negative. Seven out of the 11 patients with tumour of thoracic origin had pathological SPET findings, while 4/11 were negative.  In all, 11/24 subjects disclosed abdominal pathological uptake and 10/24 thoracic. In 6/11 abdominal cases SPET/CT allowed anatomical localization of lesions, while in 2/10 in thoracic cases.  Additional data were provided by SPET/CT in 8/24 cases (6 abdominal, 2 thoracic), by transmission images characterized as lesions not expressing somatostatin receptors.  Sensitivity of SPET alone in all carcinoids was 72%, negative predictive value (NPV) was 50% and accuracy was 78%. Considering abdominal lesions (independently of the origin) sensitivity of SPET  alone was 64.7%, NPV was 40%, accuracy was 71.4%. For thoracic lesions sensitivity of SPET alone was 83.3%, NPV was 66.7% and accuracy was 87.5%.  For SPET/CT considering together all carcinoids and also separately lesions of abdominal and of thoracic origin, sensitivity, NPV and accuracy were always 100%. In conclusion, SPET/CT imaging was more useful to anatomically detect carcinoids either in abdomen or in thorax and specifically lesions not expressing somatostatin receptors, as compared to SPET alone.
authors.affiliation: Nuclear Medicine Section, University of Perugia, S. Maria della Misericordia Perugia Hospital, S. Andrea Delle Fratte Perugia, Italy. mednuc@unipg.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Tranfaglia
authors.forename: Laura
authors.initials: L
authors.lastname: Cardinali
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gattucci
authors.forename: Michele
authors.initials: M
authors.lastname: Scialpi
authors.forename: Piero
authors.initials: P
authors.lastname: Ferolla
authors.forename: Helmut
authors.initials: H
authors.lastname: Sinzinger
authors.forename: Barbara
authors.initials: B
authors.lastname: Palumbo
mesh_terms: D002276:Carcinoid Tumor; D006801:Humans; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed