title: Actinic granuloma occurring in an unusual association with cutaneous B-cell chronic lymphocytic leukemia.
abstract: Granulomatous cutaneous reactions are well described in association with T-cell non-Hodgkin lymphoma and Hodgkin lymphoma, but are rarely seen in association with B-cell non-Hodgkin lymphoma or leukemia. We report a case of a 65-year-old woman with B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented with multiple, tender, firm pink papules on the face, upper trunk and upper extremities 6 years after diagnosis of CLL. Biopsy revealed both palisading granulomatous dermatitis consistent with actinic granuloma and a dense perivascular lymphocytic infiltrate consistent with the patient's known history of leukemia. This is an unusual manifestation of cutaneous B-cell CLL that is rarely seen.
authors.affiliation: Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA. juliakauffman@hotmail.com
authors.forename: Julia A
authors.initials: JA
authors.lastname: Kauffman
authors.forename: Doina
authors.initials: D
authors.lastname: Ivan
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Cutlan
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Hymes
mesh_terms: D000368:Aged; D003872:Dermatitis / Q000473:pathology; D005153:Facial Neoplasms / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*