title: The Two Faces of NF-κB Signaling in Cancer Development and Therapy.
abstract: Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby exerting a tumor-suppressor function.
authors.affiliation: Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. uk30@columbia.edu
authors.forename: Ulf
authors.initials: U
authors.lastname: Klein
authors.forename: Sankar
authors.initials: S
authors.lastname: Ghosh
references.citation: Genes Dev. 2011 Oct 15;25(20):2137-46
references.pmid: 21979374
references.citation: Nat Rev Cancer. 2009 Feb;9(2):81-94
references.pmid: 19132009
references.citation: PLoS Biol. 2008 Dec 2;6(12):2853-68
references.pmid: 19053174
references.citation: Genes Dev. 2011 Oct 15;25(20):2125-36
references.pmid: 21979375
references.citation: Nat Immunol. 2011 Sep 20;12(10):933-40
references.pmid: 21934679
references.citation: Nat Immunol. 2011 Jul 19;12(8):715-23
references.pmid: 21772280
references.citation: Cell. 2002 May 3;109(3):335-46
references.pmid: 12015983
references.citation: Genes Dev. 2010 Nov 15;24(22):2463-79
references.pmid: 21078816
references.citation: Cell. 2008 Feb 8;132(3):344-62
references.pmid: 18267068