title: Induction of cyclin D1 by arsenite and UVB-irradiation in human keratinocytes.
abstract: Arsenic is an environmental pollutant with carcinogenic properties that is found in many regions of the world but that poses a health risk primarily in economically disadvantaged areas. In these areas, arsenic ingestion affects various tissues, especially skin in which it acts as a comutagen with the ultraviolet component of solar radiation. Both epidemiological and experimental evidence indicates that arsenic and ultraviolet radiation act on signaling pathways that effect the expression of cyclin D1. We have previously employed an in vitro model system of human epidermal keratinocytes to study the effects of submicromolar concentrations of sodium arsenite on cyclin D1 expression. Here, we employed this system to demonstrate concordant cyclin D1-related induction profiles of ultraviolet B radiation and arsenite using cDNA microarray analysis. We also show that both of these agents act epigenetically to bring about demethylation of the cyclin D1 promoter.
authors.affiliation: Department of Chemistry, The City College of New York, Convent Avenue and 138th Street, New York, NY 10031, USA.
authors.forename: Suqing
authors.initials: S
authors.lastname: Liu
authors.forename: Julian
authors.initials: J
authors.lastname: Gonzalez
authors.forename: Bor-Jang
authors.initials: BJ
authors.lastname: Hwang
authors.forename: Mark L
authors.initials: ML
authors.lastname: Steinberg
mesh_terms: D018053:Arsenites / Q000378:metabolism / Q000494:pharmacology*; D015153:Blotting, Western; D002273:Carcinogens / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism*; D004781:Environmental Exposure; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D014466:Ultraviolet Rays / Q000009:adverse effects*; D060449:Wnt Signaling Pathway / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects
chemical_list: D018053:Arsenites; D002273:Carcinogens; D019938:Cyclin D1
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