title: Metal to ligand charge transfer induced DNA photobinding in a Ru(II)-Pt(II) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification.
abstract: The Ru(II)-Pt(II) supramolecular complex, [(Ph(2)phen)(2)Ru(dpp)PtCl(2)](2+), displays a new mechanism for DNA modification: photobinding through a (3)MLCT excited state. Gel shift analysis, selective DNA precipitation, and DNA melting point experiments support efficient covalent DNA binding following visible light excitation.
authors.affiliation: Virginia Polytechnic Institute and State University, Department of Chemistry, Blacksburg, VA 24061-0212, USA.
authors.forename: Samantha L H
authors.initials: SL
authors.lastname: Higgins
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Tucker
authors.forename: Brenda S J
authors.initials: BS
authors.lastname: Winkel
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Brewer
mesh_terms: D000818:Animals; D002417:Cattle; D011232:Chemical Precipitation; D003116:Color; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004579:Electron Transport; D008024:Ligands; D008027:Light; D009691:Nucleic Acid Denaturation; D010778:Photochemotherapy / Q000379:methods*; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism; D044366:Transition Temperature
chemical_list: D008024:Ligands; D010984:Platinum; D012428:Ruthenium; D004247:DNA