title: Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents.
abstract: A series of new isatin-thiazoline 3a-h and isatin-benzimidazole 4a-h derivatives were synthesized via condensation of isatin Mannich bases 2a-h with either 2-aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were characterized by spectral data. The anti-breast cancer activity of some of the synthesized compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compounds 4b, 4d and 4g possess significant antiproliferative activity against MCF-7 cells.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. azzataher2005@yahoo.com
authors.forename: Azza T
authors.initials: AT
authors.lastname: Taher
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Khalil
authors.forename: Eman M
authors.initials: EM
authors.lastname: Ahmed
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D007510:Isatin / Q000138:chemical synthesis* / Q000494:pharmacology*; D061986:MCF-7 Cells; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007202:Indicators and Reagents; D013844:Thiazoles; D007510:Isatin