title: MCP-1 and CCR2 gene variants and the risk for osteoporosis and osteopenia.
abstract: OBJECTIVE
  In this study, we investigated whether monocyte chemotactic protein 1 (MCP-1) and CC chemokine receptor 2 (CCR2) gene polymorphisms account for an increased risk of osteoporosis or osteopenia.
  
  
  METHODS
  Three hundred three postmenopausal women, 80 osteoporotic, 123 osteopenic, and 100 unrelated age-matched healthy controls, were included in the study. Genotyping of MCP-1 A2518G and CCR2 V64I gene polymorphisms were detected by PCR-RFLP.
  
  
  RESULTS
  We, for the first time, demonstrated the positive association of MCP-1 GG, CCR2 Val/Ile, and CCR2 Val+ genotype with osteoporosis risk. However, CCR2 Ile/Ile genotype frequencies were high in the control group compared with those of the patients with osteoporosis and osteopenia. Haplotype analysis confirmed the association of MCP-1/CCR2 gene variants with osteopenia and revealed that the frequency of MCP-1 A:CCR2 Val haplotype was significantly higher in patients when compared with controls.
  
  
  CONCLUSIONS
  In conclusion, our findings have suggested that MCP-1 and CCR2 gene variants were risk factors for osteoporosis and osteopenia.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Azerbaijan Medical University, Baku, Azerbaijan.
authors.forename: Hakan
authors.initials: H
authors.lastname: Eraltan
authors.forename: Canan
authors.initials: C
authors.lastname: Cacina
authors.forename: Ozlem Timirci
authors.initials: OT
authors.lastname: Kahraman
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kurt
authors.forename: Hulya Yilmaz
authors.initials: HY
authors.lastname: Aydogan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uyar
authors.forename: Ayşe
authors.initials: A
authors.lastname: Can
authors.forename: Bedia
authors.initials: B
authors.lastname: Cakmakoğlu
mesh_terms: D000328:Adult; D000368:Aged; D001851:Bone Diseases, Metabolic / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause; D054390:Receptors, CCR2 / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2; D054390:Receptors, CCR2