title: One-step fabrication of biocompatible chitosan-coated ZnS and ZnS:Mn2+ quantum dots via a γ-radiation route.
abstract: Biocompatible chitosan-coated ZnS quantum dots [CS-ZnS QDs] and chitosan-coated ZnS:Mn2+ quantum dots [CS-ZnS:Mn2+ QDs] were successfully fabricated via a convenient one-step γ-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS:Mn2+ QDs showed low cytotoxicity and good biocompatibility, which offered possibilities for further biomedical applications. Moreover, this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan.PACS: 81.07.Ta; 78.67.Hc; 82.35.Np; 87.85.Rs.
authors.affiliation: College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, People's Republic of China. chsq@nuaa.edu.cn.
authors.forename: Shu-Quan
authors.initials: SQ
authors.lastname: Chang
authors.forename: Bin
authors.initials: B
authors.lastname: Kang
authors.forename: Yao-Dong
authors.initials: YD
authors.lastname: Dai
authors.forename: Hong-Xu
authors.initials: HX
authors.lastname: Zhang
authors.forename: Da
authors.initials: D
authors.lastname: Chen
references.citation: Biomaterials. 2005 May;26(15):2733-9
references.pmid: 15585277
references.citation: J Biomed Mater Res A. 2005 Oct 1;75(1):56-62
references.pmid: 16086419
references.citation: Langmuir. 2004 Jul 6;20(14):6071-3
references.pmid: 16459632
references.citation: Nanoscale Res Lett. 2011 Apr 06;6(1):299
references.pmid: 21711857
references.citation: Nanoscale Res Lett. 2011 Jun 24;6(1):438
references.pmid: 21711502
references.citation: Nanoscale Res Lett. 2011 Jun 13;6(1):418
references.pmid: 21711951
references.citation: Nat Biotechnol. 2004 Aug;22(8):969-76
references.pmid: 15258594
references.citation: Nanotechnology. 2008 Jan 16;19(2):025601
references.pmid: 21817543
references.citation: Science. 2005 Jan 28;307(5709):538-44
references.pmid: 15681376
references.citation: Inorg Chem. 2007 Feb 19;46(4):1354-60
references.pmid: 17243762
references.citation: Int J Nanomedicine. 2011;6:765-74
references.pmid: 21589644
references.citation: J Nanosci Nanotechnol. 2009 Oct;9(10):5693-700
references.pmid: 19908440
references.citation: Environ Health Perspect. 2005 Jul;113(7):823-39
references.pmid: 16002369
references.citation: J Nanosci Nanotechnol. 2005 Sep;5(9):1364-75
references.pmid: 16193951