title: Different incidence of synchronous liver metastasis between proximal and distal colon cancer.
abstract: OBJECTIVE
  The clinicopathological features of colon cancer differ between proximal and distal sites; however, the influence of tumor location on liver metastasis has not been fully examined. The aim of this study was to evaluate the differences in the features of liver metastasis between proximal and distal colon cancer.
  
  
  METHODS
  The clinicopathological data from 931 colon cancer patients who were treated surgically were examined retrospectively using a multivariate analysis.
  
  
  RESULTS
  The incidence of synchronous liver metastasis was 7.1% (31/438) in proximal colon patients and 11.6% (57/493) in distal colon patients. Both univariate and multivariate analyses showed distal colon cancer to be a risk factor for synchronous liver metastasis.
  
  
  CONCLUSIONS
  The incidence of synchronous liver metastasis differs between proximal and distal colon cancer.
authors.affiliation: Department of Surgery, Fukuoka Teishin Hospital, 2-6-11 Yakuin, Chuo-ku, Fukuoka, 810-8798, Japan. alfadai@pearl.ocn.ne.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Waki
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kakeji
authors.forename: Shunichi
authors.initials: S
authors.lastname: Tsujitani
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
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