title: Influenza neuraminidase.
abstract: Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Gillian-air@ouhsc.edu
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Air
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007252:Influenza Vaccines / Q000276:immunology; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000187:drug effects / Q000201:enzymology*; D011487:Protein Conformation; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007252:Influenza Vaccines; D014764:Viral Proteins; D009439:Neuraminidase
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