title: The cellular antiviral restriction factor tetherin does not inhibit poxviral replication.
abstract: Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.
authors.affiliation: Paul-Ehrlich-Institut, Langen, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Sliva
authors.forename: Theresa
authors.initials: T
authors.lastname: Resch
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kraus
authors.forename: Christine
authors.initials: C
authors.lastname: Goffinet
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Keppler
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Schnierle
mesh_terms: D015703:Antigens, CD / Q000502:physiology*; D002460:Cell Line; D058851:GPI-Linked Proteins / Q000502:physiology; D006801:Humans; D014616:Vaccinia virus / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2
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