title: Myxoma virus induces apoptosis in cultured feline carcinoma cells.
abstract: There is growing interest in utilizing replicating oncolytic viruses as cancer therapeutics agents. The effectiveness of myxoma virus-induced oncolysis was evaluated in two feline cancer cell cultures. Although myxoma virus is a rabbit-specific pathogen, protein expression driven by myxoma virus and production of infectious viral particles were detected. Cell death occurred in primary feline cancer cells within 48 h of inoculation with myxoma virus. Future studies to determine if other feline neoplasms are susceptible to myxoma virus infection are warranted.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA. almac@illinois.edu
authors.forename: A L
authors.initials: AL
authors.lastname: MacNeill
authors.forename: T
authors.initials: T
authors.lastname: Moldenhauer
authors.forename: R
authors.initials: R
authors.lastname: Doty
authors.forename: T
authors.initials: T
authors.lastname: Mann
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002277:Carcinoma / Q000821:virology*; D002371:Cat Diseases; D002415:Cats; D018929:Cell Culture Techniques; D005260:Female; D015674:Mammary Neoplasms, Animal; D009233:Myxoma virus / Q000502:physiology*