title: Multifocal presentation of medulloblastoma in adulthood.
abstract: Medulloblastoma in adulthood is uncommon but not rare; annual incidence is 2-20/1,000,000. Some peculiarities characterize medulloblastoma in adult patients compared with the child type: lateral cerebellar location, heterogeneous signal intensity on magnetic resonance imaging, desmoplastic histological variant, and more favourable prognosis. Preoperative diagnosis is crucial for correct management of these patients. However, because of the low incidence of medulloblastoma in the adult population, preoperative diagnosis remains challenging and prognostic factors and best treatment options are still controversial. In this setting, some unusual findings, for example multifocal presentation and extra-axial location, can confound diagnosis and make treatment difficult. We present a short case-illustrated review on these remarkable issues.
authors.affiliation: Department of Neurosurgery, Padua University Hospital, Via Giustiniani 2, Azienda Ospedaliera di Padova, 35128 Padua, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Ciccarino
authors.forename: Antonino
authors.initials: A
authors.lastname: Rotilio
authors.forename: Marta
authors.initials: M
authors.lastname: Rossetto
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Enrico
authors.initials: E
authors.lastname: Orvieto
authors.forename: Franco
authors.initials: F
authors.lastname: Berti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lombardi
authors.forename: Domenico
authors.initials: D
authors.lastname: d'Avella
authors.forename: Renato
authors.initials: R
authors.lastname: Scienza
authors.forename: Alessandro
authors.initials: A
authors.lastname: Della Puppa
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery
references.citation: J Neurooncol. 2002 Aug;59(1):49-61
references.pmid: 12222838
references.citation: Clin Neurol Neurosurg. 2009 Jul;111(6):540-3
references.pmid: 19285790
references.citation: Can J Surg. 2009 Aug;52(4):E101-E102
references.pmid: 19680492
references.citation: Cancer. 2007 Jun 15;109(12):2557-65
references.pmid: 17487854
references.citation: Cancer. 1994 Oct 15;74(8):2352-60
references.pmid: 7922986
references.citation: J Pediatr Hematol Oncol. 2001 Oct;23(7):431-6
references.pmid: 11878577
references.citation: Ann Neurol. 1993 Mar;33(3):308-11
references.pmid: 8498814
references.citation: Acta Neurochir (Wien). 2011 Jul;153(7):1511-7; discussion 1517
references.pmid: 21553317
references.citation: Acta Neurochir (Wien). 1998;140(7):723-4
references.pmid: 9781288
references.citation: Int J Radiat Oncol Biol Phys. 1985 Dec;11(12):2051-6
references.pmid: 4066436
references.citation: Cancer. 1981 Jul 15;48(2):384-94
references.pmid: 7237407
references.citation: J Neurosurg. 1989 Apr;70(4):536-44
references.pmid: 2926493
references.citation: Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):855-60
references.pmid: 12377339
references.citation: Semin Ultrasound CT MR. 1992 Jun;13(3):182-206
references.pmid: 1642905
references.citation: Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1255-7
references.pmid: 7607951
references.citation: J Comput Assist Tomogr. 1988 Sep-Oct;12(5):894
references.pmid: 3170856
references.citation: Neuro Oncol. 2001 Jul;3(3):167-73
references.pmid: 11465397
references.citation: Clin Neuropathol. 2009 Mar-Apr;28(2):83-90
references.pmid: 19353838
references.citation: J Neurooncol. 2009 Nov;95(2):271-279
references.pmid: 19521664
references.citation: J Neurol. 2005 Mar;252(3):291-9
references.pmid: 16189725
references.citation: J Natl Cancer Inst. 1996 May 15;88(10):675-9
references.pmid: 8627644
references.citation: J Neurosurg Sci. 1990 Jul-Dec;34(3-4):323-5
references.pmid: 2098514
references.citation: Hered Cancer Clin Pract. 2010 Jun 17;8(1):6
references.pmid: 20565722
references.citation: J Neurooncol. 2011 Jan;101(2):325-8
references.pmid: 20532810
references.citation: Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):951-7
references.pmid: 7607969
references.citation: Cancer Radiother. 1997;1(1):60-7
references.pmid: 9265535