title: Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6.
abstract: We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.
authors.affiliation: Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Shigemoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kuwahara
authors.forename: Shizuo
authors.initials: S
authors.lastname: Kayama
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimizu
authors.forename: Makoto
authors.initials: M
authors.lastname: Onodera
authors.forename: Michiya
authors.initials: M
authors.lastname: Yokozaki
authors.forename: Junzo
authors.initials: J
authors.lastname: Hisatsune
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohge
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Sugai
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D005260:Female; D022761:Gene Transfer, Horizontal; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007564:Japan; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D000077731:Meropenem; D010957:Plasmids / Q000032:analysis; D013845:Thienamycins / Q000494:pharmacology*; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; D000077731:Meropenem