title: Prevalence, pathophysiology, screening and management of osteoporosis in gastric cancer patients.
abstract: Osteoporosis in gastric cancer patients is often overlooked or even neglected despite its high prevalence in these patients. Considering that old age, malnutrition, chronic disease, chemotherapy, decreased body mass index and gastrectomy are independent risk factors for osteoporosis, it is reasonable that the prevalence of osteoporosis in gastric cancer patients would be high. Many surviving patients suffer from back pain and pathological fractures, which are related to osteoporosis. Fractures have obvious associated morbidities, negative impact on quality of life, and impose both direct and indirect costs. In the era of a >55.6% 5-year survival rate of gastric cancer and increased longevity in gastric cancer patients, it is very important to eliminate common sequelae such as osteoporosis. Fortunately, the diagnosis of osteoporosis is well established and many therapeutic agents have been shown to be effective and safe not only in postmenopausal females but also in elderly males. Recently, effective treatments of gastric cancer patients with osteoporosis using bisphosphonates, which are commonly used in postmenopausal woman, were reported.
authors.affiliation: Department of Pediatrics, Korea Cancer Central Hospital, Seoul, Korea.
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lim
authors.forename: Jong-Inn
authors.initials: JI
authors.lastname: Lee
references.citation: Calcif Tissue Int. 1985 Sep;37(5):461-6
references.pmid: 3933787
references.citation: J Bone Miner Metab. 2010 Mar;28(2):202-8
references.pmid: 19690798
references.citation: Calcif Tissue Int. 2000 Feb;66(2):119-22
references.pmid: 10652959
references.citation: Am J Vet Res. 2002 May;63(5):703-11
references.pmid: 12013472
references.citation: Sci Basis Med Annu Rev. 1970;:260-75
references.pmid: 4920182
references.citation: J Nutr. 2005 Nov;135(11):2739S-48S
references.pmid: 16251641
references.citation: Mol Cell Endocrinol. 1998 Jun 25;141(1-2):65-72
references.pmid: 9723887
references.citation: Lancet. 1996 Dec 7;348(9041):1535-41
references.pmid: 8950879
references.citation: Gastroenterology. 2003 Mar;124(3):795-841
references.pmid: 12612917
references.citation: J Orthop Sci. 2003;8(5):717-20
references.pmid: 14557940
references.citation: Gastric Cancer. 2002;5(3):177-82
references.pmid: 12378346
references.citation: Scand J Gastroenterol. 1997 Nov;32(11):1090-5
references.pmid: 9399388
references.citation: J Clin Invest. 1996 Jun 15;97(12):2692-6
references.pmid: 8675678
references.citation: World J Gastroenterol. 2007 Dec 28;13(48):6492-7
references.pmid: 18161918
references.citation: Korean J Intern Med. 2000 Jan;15(1):25-31
references.pmid: 10714088
references.citation: Mayo Clin Proc. 2008 Sep;83(9):1032-45
references.pmid: 18775204
references.citation: Ann Surg. 1997 Feb;225(2):181-92
references.pmid: 9065295
references.citation: World Health Organ Tech Rep Ser. 1994;843:1-129
references.pmid: 7941614
references.citation: Br J Cancer. 2008 Apr 22;98(8):1443-51
references.pmid: 18319718
references.citation: Bone Miner. 1990 Nov;11(2):199-208
references.pmid: 2268747
references.citation: Scand J Gastroenterol. 1982 Apr;17(3):433-9
references.pmid: 7134871
references.citation: JAMA. 1994 Dec 28;272(24):1942-8
references.pmid: 7990248
references.citation: N Engl J Med. 2007 Jul 19;357(3):266-81
references.pmid: 17634462
references.citation: Bone. 2002 Aug;31(2):319-26
references.pmid: 12151085
references.citation: J Cancer Surviv. 2009 Jun;3(2):75-88
references.pmid: 19412668
references.citation: Osteoporos Int. 2000;11(10):815-21
references.pmid: 11199184
references.citation: Gastroenterology. 1987 Mar;92(3):608-16
references.pmid: 3817384
references.citation: Bone. 2008 Jan;42(1):61-7
references.pmid: 17942383
references.citation: J Bone Miner Metab. 2008;26(6):609-17
references.pmid: 18979161
references.citation: J Cell Biochem. 2006 Dec 15;99(6):1688-704
references.pmid: 16888818
references.citation: Gut. 1991 Nov;32(11):1303-7
references.pmid: 1752460
references.citation: J Gastroenterol Hepatol. 1992 Nov-Dec;7(6):639-45
references.pmid: 1486191
references.citation: Am J Med. 1971 Apr;50(4):442-9
references.pmid: 5572594
references.citation: Bone. 1999 Jul;25(1):61-7
references.pmid: 10423023
references.citation: Am J Med. 2009 Oct;122(10):896-903
references.pmid: 19786155
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078
references.citation: Nutrition. 1999 Sep;15(9):677-82
references.pmid: 10467612
references.citation: Am J Med. 2006 Apr;119(4 Suppl 1):S3-S11
references.pmid: 16563939