title: Association of plasma epinephrine level with insulin sensitivity in metabolically healthy but obese individuals.
abstract: In the present study, we explored the association of catecholamines with insulin sensitivity in "metabolically healthy but obese" (MHO) individuals, by examining the metabolic characteristics and plasma catecholamine levels in 100 obese, sedentary postmenopausal women. Subjects were classified as MHO (n=25) or at-risk (n=25) based on the upper and lower quartiles of insulin sensitivity as measured by the hyperinsulinemic-euglycemic clamp technique. The MHO group presented a significantly higher range of plasma epinephrine levels (73 ± 21 pg/mL) than the at-risk group (39 ± 20 pg/mL) (P<0.05), though both within the normal basal range of plasma epinephrine (56 ± 30 pg/mL). Multivariate regression analysis showed that high-sensitivity C-reactive protein, plasma epinephrine, triglycerides and lean body mass index were independent predictors of glucose disposal. The plasma epinephrine level was positively correlated with the glucose disposal rate, insulin sensitivity and the HDL-cholesterol level, and negatively correlated with the triglycerides level (P<0.05). In conclusion, this study for the first time demonstrates a positive association between plasma epinephrine level and insulin sensitivity in MHO individuals.
authors.affiliation: Department of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Key Laboratory of Traditional Chinese Medicine Gan Organ of SATCM, Xiangya Hospital, Central South University, Changsha, PR China.
authors.forename: Xing-Ping
authors.initials: XP
authors.lastname: Dai
authors.forename: Zhao-Qian
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Lin-Yong
authors.initials: LY
authors.lastname: Xu
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Gong
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Dong
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002395:Catecholamines / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004837:Epinephrine / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D017698:Postmenopause / Q000502:physiology; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D002395:Catecholamines; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002097:C-Reactive Protein; D004837:Epinephrine