title: Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy.
abstract: Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.
authors.affiliation: Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY 10016, USA. tab2006@med.cornell.edu
authors.forename: Tracy
authors.initials: T
authors.lastname: Butler
authors.forename: Karen
authors.initials: K
authors.lastname: Blackmon
authors.forename: Carrie R
authors.initials: CR
authors.lastname: McDonald
authors.forename: Chad
authors.initials: C
authors.lastname: Carlson
authors.forename: William B
authors.initials: WB
authors.lastname: Barr
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
authors.forename: Ruben
authors.initials: R
authors.lastname: Kuzniecky
authors.forename: Jonathan
authors.initials: J
authors.lastname: DuBois
authors.forename: Jacqueline
authors.initials: J
authors.lastname: French
authors.forename: Eric
authors.initials: E
authors.lastname: Halgren
authors.forename: Thomas
authors.initials: T
authors.lastname: Thesen
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D003863:Depression / Q000209:etiology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales
references.citation: Biol Psychiatry. 2002 Feb 15;51(4):273-9
references.pmid: 11958777
references.citation: Epilepsy Behav. 2007 Mar;10(2):242-9
references.pmid: 17215168
references.citation: J Clin Psychol. 1999 Jan;55(1):117-28
references.pmid: 10100838
references.citation: J Comp Neurol. 1990 Oct 22;300(4):549-71
references.pmid: 2273093
references.citation: Psychol Med. 2004 Aug;34(6):1059-64
references.pmid: 15554576
references.citation: Neurology. 2004 Jan 27;62(2):258-61
references.pmid: 14745064
references.citation: Epilepsia. 2006 Dec;47(12):2125-30
references.pmid: 17201712
references.citation: Prog Neurobiol. 2008 Nov;86(3):216-44
references.pmid: 18824074
references.citation: Epilepsia. 2009 May;50(5):1067-71
references.pmid: 19054394
references.citation: Psychol Med. 2009 Jul;39(7):1087-96
references.pmid: 18845012
references.citation: Lancet Neurol. 2006 May;5(5):399-405
references.pmid: 16632310
references.citation: Neurology. 1999;53(5 Suppl 2):S3-8
references.pmid: 10496228
references.citation: Neurology. 2010 Jun 1;74(22):1776-84
references.pmid: 20513813
references.citation: J Neurol Neurosurg Psychiatry. 2007 Nov;78(11):1226-30
references.pmid: 17259350
references.citation: Arch Neurol. 1992 Jun;49(6):617-23
references.pmid: 1596197
references.citation: Biol Psychiatry. 2003 Aug 1;54(3):388-98
references.pmid: 12893113
references.citation: Epilepsy Behav. 2001 Apr;2(2):124-128
references.pmid: 12609195
references.citation: Epilepsy Res. 2000 Apr;39(2):121-5
references.pmid: 10759300
references.citation: J Nerv Ment Dis. 1993 Jul;181(7):444-7
references.pmid: 8320547
references.citation: Neuroimage. 2008 Jan 1;39(1):10-8
references.pmid: 17942325
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13
references.pmid: 8632988
references.citation: Neuron. 2005 Mar 3;45(5):651-60
references.pmid: 15748841
references.citation: Biol Psychiatry. 1999 Dec 15;46(12):1614-23
references.pmid: 10624542
references.citation: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
references.pmid: 10984517
references.citation: Epilepsy Behav. 2003 Oct;4 Suppl 3:S31-8
references.pmid: 14592638
references.citation: Neuroimage. 2006 Dec;33(4):1093-103
references.pmid: 17011792
references.citation: Epilepsy Behav. 2011 Sep;22(1):63-8
references.pmid: 21741882
references.citation: Hum Brain Mapp. 2009 Nov;30(11):3719-35
references.pmid: 19441021
references.citation: Epilepsy Behav. 2001 Jun;2(3):170-186
references.pmid: 12609362
references.citation: J Neurosci. 2008 Nov 19;28(47):12341-8
references.pmid: 19020027