title: Measuring the quality of neuronal identification in ensemble recordings.
abstract: Technological advances in electrode construction and digital signal processing now allow recording simultaneous extracellular action potential discharges from many single neurons, with the potential to revolutionize understanding of the neural codes for sensory, motor, and cognitive variables. Such studies have revealed the importance of ensemble neural codes, encoding information in the dynamic relationships among the action potential spike trains of multiple single neurons. Although the success of this research depends on the accurate classification of extracellular action potentials to individual neurons, there are no widely used quantitative methods for assessing the quality of the classifications. Here we describe information theoretic measures of action potential waveform isolation applicable to any dataset that have an intuitive, universal interpretation, that are not dependent on the methods or choice of parameters for single-unit isolation, and that have been validated using a dataset of simultaneous intracellular and extracellular neuronal recordings from Sprague Dawley rats.
authors.affiliation: State University of New York Downstate/New York University-Poly Joint Biomedical Engineering Program, Brooklyn, New York 11203, USA.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Neymotin
authors.forename: William W
authors.initials: WW
authors.lastname: Lytton
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Olypher
authors.forename: André A
authors.initials: AA
authors.lastname: Fenton
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004566:Electrodes; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology; D007257:Information Theory; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics; D011336:Probability; D051381:Rats; D020318:Rats, Long-Evans; D012984:Software; D013223:Statistics as Topic
references.citation: J Neurosci Methods. 1995 Dec;63(1-2):43-54
references.pmid: 8788047
references.citation: Prog Brain Res. 2001;130:345-57
references.pmid: 11480287
references.citation: J Neurophysiol. 2000 Jul;84(1):401-14
references.pmid: 10899214
references.citation: J Neurosci Methods. 2009 Mar 30;178(1):75-9
references.pmid: 19073214
references.citation: J Neurosci Methods. 2003 Aug 15;127(2):111-22
references.pmid: 12906941
references.citation: PLoS One. 2011;6(7):e22349
references.pmid: 21789250
references.citation: J Neurosci. 2011 Jun 15;31(24):8699-705
references.pmid: 21677152
references.citation: J Neurophysiol. 2007 Dec;98(6):3780-90
references.pmid: 17942615
references.citation: J Neurosci Methods. 1999 Dec 15;94(1):41-52
references.pmid: 10638814
references.citation: Neuroscience. 2005;131(1):1-11
references.pmid: 15680687
references.citation: Nat Neurosci. 2004 May;7(5):446-51
references.pmid: 15114356
references.citation: Neural Comput. 2004 Aug;16(8):1661-87
references.pmid: 15228749
references.citation: J Neurosci Methods. 2004 May 30;135(1-2):95-105
references.pmid: 15020094
references.citation: J Neurophysiol. 2004 May;91(5):2259-72
references.pmid: 14736863
references.citation: Nature. 2003 Jul 31;424(6948):552-6
references.pmid: 12891358
references.citation: J Neurophysiol. 2003 Aug;90(2):1314-23
references.pmid: 12904510
references.citation: J Neurophysiol. 2009 Aug;102(2):1331-9
references.pmid: 19535480
references.citation: Brain Res. 1990 Feb 19;509(2):299-308
references.pmid: 2322825
references.citation: IEEE Trans Biomed Eng. 2004 Jun;51(6):912-8
references.pmid: 15188858
references.citation: Hippocampus. 1993 Jul;3(3):317-30
references.pmid: 8353611
references.citation: J Neurosci. 2008 Oct 29;28(44):11250-62
references.pmid: 18971467
references.citation: Science. 1993 Aug 20;261(5124):1055-8
references.pmid: 8351520
references.citation: Network. 1998 Nov;9(4):R53-78
references.pmid: 10221571
references.citation: J Neurosci. 2006 Jan 4;26(1):158-68
references.pmid: 16399683
references.citation: Nat Rev Neurosci. 2008 Aug;9(8):626-37
references.pmid: 18594562
references.citation: J Neurophysiol. 2000 Jul;84(1):390-400
references.pmid: 10899213