title: Telling the story of XX sex reversal in the goat: highlighting the sex-crossroad in domestic mammals.
abstract: The conditions for sex reversal in vertebrate species have been studied extensively and have highlighted numerous key factors involved in sex differentiation. We review here the history of the development of knowledge, referring to one example of complete female-to-male XX sex reversal associated with a polled phenotype in the goat. The results and hypotheses concerning this polled intersex syndrome (PIS) are then presented, firstly with respect to the transcriptional regulatory effects of the PIS mutation, and secondly regarding the role of the main ovarian-differentiating factor in this PIS locus, the FOXL2 gene.
authors.affiliation: INRA, UMR 1198, ENVA, Biologie du Développement et de la Reproduction, Jouy-en-Josas, France.
authors.forename: M
authors.initials: M
authors.lastname: Pannetier
authors.forename: M
authors.initials: M
authors.lastname: Elzaiat
authors.forename: D
authors.initials: D
authors.lastname: Thépot
authors.forename: E
authors.initials: E
authors.lastname: Pailhoux
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D012734:Disorders of Sex Development / Q000235:genetics / Q000662:veterinary*; D004967:Estrogens; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics; D015511:Goat Diseases / Q000235:genetics*; D006041:Goats; D009154:Mutation; D010053:Ovary / Q000196:embryology / Q000378:metabolism; D012733:Sex Differentiation / Q000235:genetics; D013256:Steroids / Q000096:biosynthesis
chemical_list: D004268:DNA-Binding Proteins; D004967:Estrogens; D051858:Forkhead Transcription Factors; D013256:Steroids