title: [The effects of high fat diet and endurance exercise on the aorta wall structure of experimental animal].
abstract: OBJECTIVE
  Based on high fat diet induced the model of atherosclerosis (AS) in C57BL/6J mice, authors studied the effect of endurance exercise on the atherosclerostic formation.
  
  
  METHODS
  Forty eight 8-week-old C57BL/6J mice were divided into four groups randomly (n=12): control (group N), 12-week atherosclerosis model group(group H), 12-week atherosclerosis model plus 11-week treadmill training group (group H + E) and 22-week atherosclerosis model group (group HS). Then, we observed the effects of endurance exercise on the ultra structure of aorta by electron microscope.
  
  
  RESULTS
  Twenty weeks of high fat diet could result in serious AS in mice while endurance exercise could significantly antagonize or restrain the occur of AS. In addition, 10 weeks of endurance exercise could alleviate the symptom of pathological changes which already happened on aorta wall.
  
  
  CONCLUSIONS
  It indicated that endurance exercise could effectively prevent and cure AS that induced by high fat diet.
authors.affiliation: Department of Health & Exercise Science, Tianjin University of Sport, Tianjin 300381, China. liu_shanyun@163.com
authors.forename: Shan-yun
authors.initials: SY
authors.lastname: Liu
authors.forename: Yu-xiu
authors.initials: YX
authors.lastname: He
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control*; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology*
chemical_list: D004041:Dietary Fats