title: Triglycerides are independently associated with albuminuria in Taiwanese Type 2 diabetic patients.
abstract: BACKGROUND
  Lipid abnormalities in albuminuria in patients with Type 2 diabetes differ by race.
  
  
  OBJECTIVE
  To perform a biochemical investigation of association between dyslipidemia and albuminuria in Type 2 diabetes in Taiwan. MATERIALS/ SUBJECTS AND METHODS: We recruited a total of 2349 Chinese patients with Type 2 diabetes from two medical centers in Taiwan over a 1-yr period. Patients were categorized into those with normoalbuminuria, microalbuminuria, and macroalbuminuria defined as albumin-to-creatinine ratio of <30, 30- 299, and ≥300 μg/mg. We then investigated the significance of the clinical and biochemical parameters and risk of albuminuria.
  
  
  RESULTS
  We found significant differences in total cholesterol (TC) between those with normoalbuminuria and micro/ macroalbuminuria, no significant difference in LDL cholesterol (LDL-C) among the 3 subgroups, a significant difference in HDL cholesterol (HDL-C) between those with normoalbuminuria and macroalbuminuria, and significant increases in triglyceride (TG) paralleling increases in albuminuria. TG was found by logistic regression to be significantly associated with micro/macroalbuminuria in our unadjusted model [odds ratio (OR) = 1.859 (1.596~2.165)], and remained significant after adjusting for various confounders [OR = 1.415 (1.123~1.784)]. Increases in albuminuria paralleled quartile increases in serum TG (p<0.001).
  
  
  CONCLUSIONS
  We conclude that TG increases significantly throughout the 3 stages of albuminuria in Taiwanese Type 2 diabetic patients, but TC, HDL-C, and LDL-C do not.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: K-J
authors.initials: KJ
authors.lastname: Tien
authors.forename: S-T
authors.initials: ST
authors.lastname: Tu
authors.forename: H-C
authors.initials: HC
authors.lastname: Chen
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hsiao
authors.forename: M-C
authors.initials: MC
authors.lastname: Hsieh
mesh_terms: D000419:Albuminuria / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D048909:Diabetes Complications / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013624:Taiwan; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
references.citation: Ann Intern Med. 1951 Mar;34(3):592-607
references.pmid: 14811285
references.citation: Diabetes Metab. 2000 Sep;26(4):254-64
references.pmid: 11011217
references.citation: Diabetes Care. 2007 Jan;30 Suppl 1:S4-S41
references.pmid: 17192377
references.citation: Kidney Int. 2005 Apr;67(4):1547-53
references.pmid: 15780110
references.citation: Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S169-72
references.pmid: 15563971
references.citation: J Coll Physicians Surg Pak. 2004 Feb;14(2):84-7
references.pmid: 15228869
references.citation: J Am Coll Nutr. 2006 Apr;25(2):155-63
references.pmid: 16582033
references.citation: Diabetes Res Clin Pract. 1999 Oct;46(1):47-55
references.pmid: 10580616
references.citation: Diabetes Care. 1995 Feb;18(2):182-7
references.pmid: 7729295
references.citation: Kidney Int. 2006 Jun;69(11):2057-63
references.pmid: 16612330
references.citation: J Clin Invest. 2003 Aug;112(3):326-8
references.pmid: 12897200
references.citation: Lancet. 1993 Sep 25;342(8874):781-7
references.pmid: 8103879
references.citation: Diabet Med. 1990 Nov;7(9):810-4
references.pmid: 2148134
references.citation: Trends Cardiovasc Med. 2004 Jul;14(5):196-202
references.pmid: 15261892
references.citation: Arch Intern Med. 1997 Jul 14;157(13):1413-8
references.pmid: 9224218
references.citation: BMJ. 1997 Mar 15;314(7083):783-8
references.pmid: 9080995
references.citation: Lancet. 1982 Jun 26;1(8287):1430-2
references.pmid: 6123720
references.citation: Diabetes Care. 2003 Jul;26(7):2150-5
references.pmid: 12832328
references.citation: Kidney Int. 2006 May;69(10):1899-903
references.pmid: 16598198
references.citation: Arteriosclerosis. 1987 Sep-Oct;7(5):483-90
references.pmid: 3675308
references.citation: Acta Endocrinol (Copenh). 1982 Aug;100(4):550-5
references.pmid: 6812342
references.citation: Diabetes. 2006 Jun;55(6):1832-9
references.pmid: 16731850
references.citation: Kidney Int Suppl. 2005 Apr;(94):S14-8
references.pmid: 15752232