title: The value of CRP, IL-6, leptin, cortisol, and peritoneal caspase-3 monitoring in the operative strategy of secondary peritonitis.
abstract: BACKGROUND
  We aimed to investigate the impact of C-reactive protein (CRP), interleukin (IL)-6, leptin, cortisol, and caspase-3 on the decision of terminating planned abdominal repair in secondary peritonitis.
  
  
  METHODS
  Fifteen patients with peritonitis were enrolled into the study. Serum CRP, IL-6, leptin, cortisol, and peritoneal caspase-3 activities were measured.
  
  
  RESULTS
  APACHE II scores at 48 hours (h) and age were significantly higher in non-survivors. A significant decrease was observed in caspase-3 activities of patients in whom ≤4 laparotomies were performed when compared with those who underwent >4 laparotomies. For patients who underwent ≤4 laparotomies, there was a significant difference in caspase-3 levels between 0 and 72 h. There was no significant difference in caspase-3 levels in non-survivors; caspase-3 levels were significantly lower in the survivors at 48 and 72 h. Changes in CRP, IL-6, leptin, and cortisol levels were not statistically significant.
  
  
  CONCLUSIONS
  CRP, IL-6, leptin, cortisol, and caspase-3 are not valuable in discriminating the number of planned operations, even though there is a significant decrease in caspase-3 "within" survivors. The discriminative value of caspase-3 for closure should be evaluated in studies in which caspase-3 is monitored for a longer duration in a large number of patients.
authors.affiliation: Department of General Surgery, Kırıkkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Pehlivanlı
authors.forename: Fatih
authors.initials: F
authors.lastname: Ağalar
authors.forename: Canan
authors.initials: C
authors.lastname: Ağalar
authors.forename: Oral
authors.initials: O
authors.lastname: Saygun
authors.forename: Cağatay
authors.initials: C
authors.lastname: Daphan
authors.forename: Kuzey
authors.initials: K
authors.lastname: Aydınuraz
authors.forename: Unase
authors.initials: U
authors.lastname: Büyükkoçak
authors.forename: Osman
authors.initials: O
authors.lastname: Çağlayan
authors.forename: Sedat
authors.initials: S
authors.lastname: Dom
authors.forename: Tayfun
authors.initials: T
authors.lastname: Şahiner
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism*; D003657:Decision Making; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D010535:Laparoscopy; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000097:blood / Q000378:metabolism* / Q000601:surgery; D011237:Predictive Value of Tests; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein; D053148:Caspase 3; D006854:Hydrocortisone