title: Comparative investigation of the effects of different materials used with a titanium barrier on new bone formation.
abstract: OBJECTIVE
  In this study, we aimed to study the effects on new bone formation of autogenous blood, deproteinized bovine bone graft (DBBG), and biphasic calcium phosphate (BCP) bioceramic graft materials placed under titanium barriers.
  
  
  METHODS
  Twenty-four adult male New Zealand white rabbits were used in this study. Two titanium barriers were fixed on each rabbit's calvarium. The study included four groups, one of which was a control group. The experiment groups, autogenous blood, DBBG (Bio-Oss(®) ; Geistlich Biomaterials, Wolhusen, Switzerland) and BCP (4Bone(TM) ; Biomatlante, Vigneux de Bretagne, France) were placed under titanium barriers; in the control group, no materials were used. Half of the animals were sacrificed after 1 month, and the rest were sacrificed after 3 months. After this, micro-computerized tomography images were taken, and a histomorphometric evaluation was carried out.
  
  
  RESULTS
  The amounts of new bone formation were found to be higher at the third month than at the first month. The differences between the groups were examined with both a micro-computerized tomography and histomorphometric analysis, and no statistical significance was noted in the first month. In contrast, the increase in the amount of new bone formation at the third month was found to be statistically significant only between the DBBG and control groups (P < 0.05).
  
  
  CONCLUSIONS
  Autogenous blood with titanium barriers in guided bone regeneration seems to be as successful as DBBG and BCP bioceramic graft material.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093- İstanbul, Turkey. seref.ezirganli@gmail.com
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Ezirganlı
authors.forename: Serkan
authors.initials: S
authors.lastname: Polat
authors.forename: Emre
authors.initials: E
authors.lastname: Barış
authors.forename: İlkan
authors.initials: İ
authors.lastname: Tatar
authors.forename: Hakan Hamdi
authors.initials: HH
authors.lastname: Çelik
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001769:Blood; D018786:Bone Substitutes / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D006882:Hydroxyapatites / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D014025:Titanium / Q000494:pharmacology*; D055114:X-Ray Microtomography
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D006882:Hydroxyapatites; D008903:Minerals; C074950:hydroxyapatite-beta tricalcium phosphate; D014025:Titanium