title: Low back pain as the presenting sign in a patient with primary extradural melanoma of the thoracic spine--a metastatic disease 17 years after complete surgical resection.
abstract: Primary spinal melanomas are extremely rare lesions. In 1906, Hirschberg reported the first primary spinal melanoma, and since then only 40 new cases have been reported. A 47-year-old man was admitted suffering from low back pain, fatigue and loss of body weight persisting for three months. He had a 17-year-old history of an operated primary spinal melanoma from T7-T9, which had remained stable for these 17 years. Routine laboratory findings and clinical symptoms aroused suspicion of a metastatic disease. Multislice computed tomography and magnetic resonance imaging revealed stage-IV melanoma with thoracic, abdominal and skeletal metastases without the recurrence of the primary process. Transiliac crest core bone biopsy confirmed the diagnosis of metastatic melanoma. It is important to know that in all cases of back ore skeletal pain and unexplained weight loss, malignancy must always be considered in the differential diagnosis, especially in the subjects with a positive medical history. Patients who have back, skeletal, or joint pain that is unresponsive to a few weeks of conservative treatment or have known risk factors with or without serious etiology, are candidates for imaging studies. The present case demonstrates that complete surgical resection alone may result in a favourable outcome, but regular medical follow-up for an extended period, with the purpose of an early detection of a metastatic disease, is highly recommended.
authors.affiliation: Department of Oncology, University Hospital Centre (KBC Zagreb), University of Zagreb School of Medicine, Zagreb, Croatia. darko.katalinic@kbc-zagreb.hr
authors.forename: Darko
authors.initials: D
authors.lastname: Katalinic
authors.forename: Branimir
authors.initials: B
authors.lastname: Anic
authors.forename: Ranka
authors.initials: R
authors.lastname: Stern-Padovan
authors.forename: Miroslav
authors.initials: M
authors.lastname: Mayer
authors.forename: Mirna
authors.initials: M
authors.lastname: Sentic
authors.forename: Nada
authors.initials: N
authors.lastname: Cikes
authors.forename: Kamelija
authors.initials: K
authors.lastname: Zarkovic
authors.forename: Snjezana
authors.initials: S
authors.lastname: Dotlic
authors.forename: Stjepko
authors.initials: S
authors.lastname: Plestina
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D017116:Low Back Pain / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D011183:Postoperative Complications; D013125:Spinal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013899:Thoracic Neoplasms / Q000473:pathology*; D013904:Thoracic Vertebrae / Q000473:pathology*; D014057:Tomography, X-Ray Computed
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