title: Minor histocompatibility antigens as risk factor for poor prognosis in kidney transplantation.
abstract: Progress in transplantation has relied on similar human leukocyte antigen (HLA) matching between the donor and the patient, while the role of other immunologic factors like non-HLA markers including minor histocompatibility antigens (miHA) are currently in the forefront. miHA are polymorphic proteins that vary even in monozygotic twins. The best known is the H-Y antigen, but there are also other autosomal miHA and MICA (MHC class I chain-related gene A). miHA have been well studied in transplantation of hematopoietic precursors, but not in solid organ transplantation. The most important studies in this field relate to incompatibility of H-Y antigen as a risk factor in kidney transplantation, although the findings are still inconclusive. This review presents the role of minor histocompatibility antigens in solid organ transplantation, especially of the kidney.
authors.affiliation: Organ and Tissues Transplant Group, Medical School, National University of Colombia, Bogotá, Colombia. mapabonp@unal.edu.co
authors.forename: M A
authors.initials: MA
authors.lastname: Pabón
authors.forename: C E
authors.initials: CE
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
authors.forename: I
authors.initials: I
authors.lastname: Martin
authors.forename: L
authors.initials: L
authors.lastname: Gaitán
authors.forename: A
authors.initials: A
authors.lastname: Gómez
authors.forename: E
authors.initials: E
authors.lastname: Lozano
mesh_terms: D000818:Animals; D006084:Graft Rejection; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000276:immunology; D006182:H-Y Antigen / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D051379:Mice; D015778:Minor Histocompatibility Antigens / Q000276:immunology* / Q000378:metabolism; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000628:therapy; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D006182:H-Y Antigen; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D015778:Minor Histocompatibility Antigens