title: Diabetes: impaired damage control.
abstract: A coordinated response by the innate immune system, (micro)circulation and nervous system is needed to limit tissue destruction and to initiate reparative processes after tissue damage. Alterations in danger signals in diabetes can be an important cause of the excessive tissue loss and defective tissue repair after injury and can contribute to the higher rates of cardiac failure after myocardial infarction, more severe tissue loss in the case of peripheral ischaemia and impaired wound healing. Here we discuss the mechanisms underlying this impaired damage control in diabetes, with an emphasis on the proinflammatory cytokine high mobility group box 1 and the potential role of dipeptidyl peptidase IV inhibition in improving repair responses.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre, PO Box 5600, 6202 AZ Maastricht, The Netherlands. n.schaper@mumc.nl
authors.forename: N C
authors.initials: NC
authors.lastname: Schaper
authors.forename: B
authors.initials: B
authors.lastname: Havekes
mesh_terms: D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D005260:Female; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D024243:HMGB1 Protein; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
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