title: An omics perspective of protein disorder.
abstract: Disordered regions within proteins have increasingly been associated with various cellular functions. Identifying the specific roles played by disorder in these functions has proved difficult. However, the development of reliable prediction algorithms has expanded the study of disorder from a few anecdotal examples to a proteome-wide scale. Moreover, the recent omics revolution has provided the sequences of numerous organisms as well as thousands of genome-wide data sets including several types of interactomes. Here, we review the literature regarding genome-wide studies of disorder and examine how these studies give rise to new characterizations and categories of this elusive phenomenon.
authors.affiliation: Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Bellay
authors.forename: Magali
authors.initials: M
authors.lastname: Michaut
authors.forename: TaeHyung
authors.initials: T
authors.lastname: Kim
authors.forename: Sangjo
authors.initials: S
authors.lastname: Han
authors.forename: Recep
authors.initials: R
authors.lastname: Colak
authors.forename: Chad L
authors.initials: CL
authors.lastname: Myers
authors.forename: Philip M
authors.initials: PM
authors.lastname: Kim
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D006801:Humans; D011485:Protein Binding; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D040901:Proteomics
chemical_list: D011506:Proteins