title: A comparison of MR imaging of a mouse model of glioma at 0.2 T and 9.4 T.
abstract: Both 0.2 T and 9.4 T MRI systems were used to image a mouse model of glioma. RF coils were designed for both fields. A spin-echo, multi-echo pulse sequence was used to determine T(2) relaxation times of both brain and tumor tissues. Contrast-to-noise ratio was calculated based on the selected echo time. The results showed that 0.2 T is suitable for mouse model imaging, however total scan time must be long to achieve high enough SNR. T(2) relaxation times of the tumor and brain tissues can be measured at 0.2 T and are 2.1 and 1.8 times respectively longer at 0.2 T than at 9.4 T. Contrast to noise ratio for tumor and brain was better at high field than at the low field. We concluded that 0.2 T may be used to study mouse model of glioma using spin echo pulse sequence, yet the total scan time is long (about 40 min), resolution is lower (∼250 μm × 250 μm) and slice thickness (3mm) must be large enough to obtain sufficient SNR.
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada; Polish Academy of Sciences, Institute of Nuclear Physics, Krakow, 152 Radzikowskiego, Krakow, Malopolska 31-342, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Blasiak
authors.affiliation: Institute for Biodiagnostics, National Research Council of Canada, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada.
authors.forename: Vyacheslav
authors.initials: V
authors.lastname: Volotovskyy
authors.affiliation: Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada.
authors.forename: Charlie
authors.initials: C
authors.lastname: Deng
authors.affiliation: Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Foniok
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada; Polish Academy of Sciences, Institute of Nuclear Physics, Krakow, 152 Radzikowskiego, Krakow, Malopolska 31-342, Poland; Institute for Biodiagnostics, National Research Council of Canada, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada; Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada. Electronic address: Boguslaw.tomanek@nrc.ca.
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Tomanek
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000662:veterinary*; D008280:Magnetics / Q000295:instrumentation*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity