title: Changes of peroxisome proliferator-activated receptor-γ on crushed rat sciatic nerves and differentiated primary Schwann cells.
abstract: Peroxisome proliferator-activated receptor-γ (PPAR-γ) has been found to play an essential role in cell proliferation, but whether it was involved in Schwann cells differentiation has never been studied. We have found in sciatic nerve injury that expression of PPAR-γ decreases mainly in Schwann cells, and it was also increased in differentiated Schwann cells. Further, activated PPAR-γ by the endogenous ligand 15 d-PGJ(2) increased expressions of PPAR-γ level and Schwann cell differentiation, and this effect may be protected by its antagonist GDW9662. These results indicate that PPAR-γ could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.
authors.affiliation: Department of Orthopaedics, the First Affiliated Hospital, Medical College, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhengming
authors.initials: Z
authors.lastname: Zhou
authors.forename: Youhua
authors.initials: Y
authors.lastname: Wang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Ji
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D009409:Nerve Crush / Q000379:methods; D009416:Nerve Regeneration / Q000502:physiology; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D061251:Primary Cell Culture; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D020426:Sciatic Neuropathy / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology
chemical_list: D047495:PPAR gamma
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