title: SERS assisted ultra-fast peptidic screening: a new tool for drug discovery.
abstract: Herein we present a direct label-free ultra-fast method for the identification and classification of the active members of a combinatorial library directly on the solid support used for their synthesis. The method is based on the appropriate functionalization of polyethylene glycol grafted polystyrene (TentaGel®) microbeads with Au@Ag nanoparticles, the use of these materials directly as solid-phase supports for the synthesis of combinatorial libraries of peptides and the subsequent SERS analysis for identification of each peptide on each bead.
authors.affiliation: National Institute for Nanotechnology, National Research Council, 11421 Saskatchewan Drive, Edmonton, AB, Canada. perezpin@ualberta.ca
authors.forename: Rolando
authors.initials: R
authors.lastname: Pérez-Pineiro
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Correa-Duarte
authors.forename: Veronica
authors.initials: V
authors.lastname: Salgueirino
authors.forename: Ramon A
authors.initials: RA
authors.lastname: Alvarez-Puebla
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D019151:Peptide Library; D010455:Peptides; D011137:Polystyrenes; D012834:Silver; D006046:Gold