title: How chromatin prevents genomic rearrangements: locus colocalization induced by transcription factor binding.
abstract: The loosening of chromatin structures gives rise to unrestricted access to DNA and thus transcription factors (TFs) can bind to their otherwise masked target sequences. Regions bound by the same set of TFs tend to be located in close proximity and this might increase the probability of activating illegitimate genomic rearrangements.
authors.affiliation: INSERM AVENIR Team, Institute of Human Genetics, CNRS UPR 1142, Montpellier, France. jerome.dejardin@igh.cnrs.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Déjardin
mesh_terms: D000818:Animals; D002503:Centromere / Q000235:genetics; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D059765:Homologous Recombination; D006801:Humans; D011401:Promoter Regions, Genetic; D016615:Telomere; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014178:Translocation, Genetic
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA