title: Recombinant human IGF-1 (insulin-like growth factor) therapy: where do we stand today?
abstract: Recombinant human (rh) IGF-1 has been available for therapy since the 1980s and has been commercially available for over 5 y, yet the role of rhIGF-1 in treating children with short stature remains ambiguous. This is consequent to the inherent difficulty in defining criteria for IGF-1 deficiency, and in determining the outcome of rhIGF-1 therapy in terms of growth rate and adult height. The rationale for its efficacy compared with rhGH (recombinant human growth hormone) for treatment of short stature is still widely debated. Additionally, adverse events such as increased intracranial pressure and hypoglycemia are of therapeutic concern. The goal of this article is to review published data that describes the impact of IGF-1 therapy in treatment of short stature and other growth disorders.
authors.affiliation: Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Room 539, 175 Cambridge Street, Boston, MA 02114, USA.
authors.forename: Bharti
authors.initials: B
authors.lastname: Balhara
authors.forename: Madhusmita
authors.initials: M
authors.lastname: Misra
authors.forename: Lynne L
authors.initials: LL
authors.lastname: Levitsky
mesh_terms: D002648:Child; D006130:Growth Disorders / Q000188:drug therapy*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I
references.citation: J Clin Endocrinol Metab. 1993 Dec;77(6):1465-71
references.pmid: 7505286
references.citation: Acta Paediatr Suppl. 1994 Apr;399:137-9
references.pmid: 7949599
references.citation: J Clin Endocrinol Metab. 2010 Jul;95(7):3149-53
references.pmid: 20427500
references.citation: N Engl J Med. 1987 Jul 16;317(3):137-40
references.pmid: 3299085
references.citation: Horm Res. 2006;65 Suppl 1:21-7
references.pmid: 16508330
references.citation: J Pediatr Endocrinol Metab. 1995 Jul-Sep;8(3):149-58
references.pmid: 8521188
references.citation: Best Pract Res Clin Endocrinol Metab. 2002 Sep;16(3):433-47
references.pmid: 12464227
references.citation: J Pediatr. 1986 Sep;109(3):428-33
references.pmid: 3746530
references.citation: Endocr Rev. 1989 Feb;10(1):68-91
references.pmid: 2666112
references.citation: Growth Horm IGF Res. 2006 Jul;16 Suppl A:S3-5
references.pmid: 16690339
references.citation: J Clin Endocrinol Metab. 2007 Mar;92(3):902-10
references.pmid: 17192294
references.citation: J Clin Endocrinol Metab. 1995 Apr;80(4):1393-8
references.pmid: 7536209
references.citation: J Clin Endocrinol Metab. 2006 Nov;91(11):4235-6
references.pmid: 16954153
references.citation: J Clin Endocrinol Metab. 2001 Nov;86(11):5176-83
references.pmid: 11701674
references.citation: Endocr Rev. 2003 Dec;24(6):782-801
references.pmid: 14671005
references.citation: J Biol Chem. 1998 Mar 13;273(11):6074-9
references.pmid: 9497324
references.citation: J Clin Endocrinol Metab. 2006 Nov;91(11):4232-4
references.pmid: 16954154
references.citation: Endocr Rev. 2007 Feb;28(1):20-47
references.pmid: 16931767
references.citation: Horm Res. 1999;51(3):128-34
references.pmid: 10461018
references.citation: J Clin Endocrinol Metab. 2008 Jan;93(1):10-8
references.pmid: 18165284
references.citation: Endocrinol Metab Clin North Am. 1996 Sep;25(3):591-614
references.pmid: 8879988
references.citation: J Clin Endocrinol Metab. 1997 Dec;82(12):3944-51
references.pmid: 9398693
references.citation: J Pediatr. 2007 Jan;150(1):7-11
references.pmid: 17188604
references.citation: J Bone Miner Res. 2010 Dec;25(12):2543-52
references.pmid: 20836088
references.citation: Lancet. 2006 Aug 12;368(9535):612-6
references.pmid: 16905026
references.citation: Hormones (Athens). 2008 Jan-Mar;7(1):24-7
references.pmid: 18359741
references.citation: Horm Res. 1994;42(4-5):140-4
references.pmid: 7532612
references.citation: J Clin Endocrinol Metab. 1997 Feb;82(2):629-33
references.pmid: 9024266
references.citation: J Clin Endocrinol Metab. 2010 Feb;95(2):611-9
references.pmid: 19880790
references.citation: Eur J Endocrinol. 2011 Apr;164(4):485-9
references.pmid: 21292919
references.citation: J Clin Endocrinol Metab. 2004 Jan;89(1):425-32
references.pmid: 14715881
references.citation: Diabetologia. 1991 Jan;34(1):17-20
references.pmid: 1647334
references.citation: Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):277-89
references.pmid: 17101287
references.citation: Exp Neurol. 1997 Oct;147(2):418-27
references.pmid: 9344566
references.citation: J Hepatol. 2005 Oct;43(4):630-6
references.pmid: 16024131
references.citation: Acta Paediatr. 2005 Sep;94(9):1232-7
references.pmid: 16203673
references.citation: Horm Res. 2003;60(5):237-46
references.pmid: 14614229
references.citation: Clin Endocrinol (Oxf). 1998 Jan;48(1):81-7
references.pmid: 9509072
references.citation: Curr Opin Investig Drugs. 2005 Apr;6(4):373-7
references.pmid: 15898344
references.citation: Endocr Rev. 1994 Jun;15(3):369-90
references.pmid: 8076588
references.citation: Acta Paediatr Suppl. 1994 Apr;399:117-24
references.pmid: 7949595
references.citation: J Clin Endocrinol Metab. 2002 Oct;87(10):4754-65
references.pmid: 12364470