title: Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery.
abstract: The efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co(0.5)Zn(0.5))Fe(2)O(4) in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects.
authors.affiliation: Department of Mechanical Engineering, Wichita State University, KS, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Wamocha
authors.forename: H E
authors.initials: HE
authors.lastname: Misak
authors.forename: Z
authors.initials: Z
authors.lastname: Song
authors.forename: H Y
authors.initials: HY
authors.lastname: Chu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Asmatulu
authors.forename: S-Y
authors.initials: SY
authors.lastname: Yang
authors.forename: J C
authors.initials: JC
authors.lastname: Ho
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems / Q000009:adverse effects*; D005472:Fluorouracil / Q000008:administration & dosage / Q000633:toxicity; D019344:Lactic Acid; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D008422:Materials Testing; D051379:Mice; D053761:Nanocomposites / Q000008:administration & dosage / Q000633:toxicity*; D036103:Nanotechnology; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005472:Fluorouracil