title: Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study.
abstract: OBJECTIVE
  To evaluate the GABA(A) receptor in the autistic brain, we performed (123)I-IMZ SPECT in patients with ASD. We compared (123)I-IMZ SPECT abnormalities in patients who showed intellectual disturbance or focal epileptic discharge on EEG to those in patients without such findings.
  
  
  METHODS
  The subjects consisted of 24 patients with ASD (mean age, 7.3±3.5 years), including 9 with autistic disorder (mean age, 7.0±3.7 years) and 15 with Asperger's disorder (mean age, 7.5±3.2 years). We used 10 non-symptomatic partial epilepsy patients (mean age, 7.8±3.6 years) without intellectual delay as a control group. For an objective evaluation of the (123)I-IMZ SPECT results, we performed an SEE (Stereotactic Extraction Estimation) analysis to describe the decrease in accumulation in each brain lobule numerically.
  
  
  RESULTS
  In the comparison of the ASD group and the control group, there was a dramatic decrease in the accumulation of (123)I-IMZ in the superior and medial frontal cortex. In the group with intellectual impairment and focal epileptic discharge on EEG, the decrease in accumulation in the superior and medial frontal cortex was greater than that in the group without these findings.
  
  
  CONCLUSIONS
  The present results suggest that disturbance of the GABAergic nervous system may contribute to the pathophysiology and aggravation of ASD, since the accumulation of (123)I-IMZ was decreased in the superior and medial frontal cortex, which is considered to be associated with inference of the thoughts, feelings, and intentions of others (Theory of Mind).
authors.affiliation: Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan. mori-tatsu@clin.med.tokushima-u.ac.jp
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Mori
authors.forename: Kenji
authors.initials: K
authors.lastname: Mori
authors.forename: Emiko
authors.initials: E
authors.lastname: Fujii
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Toda
authors.forename: Masahito
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Kagami
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000000981:diagnostic imaging* / Q000378:metabolism; D002675:Child, Preschool; D005442:Flumazenil / Q000031:analogs & derivatives; D006801:Humans; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D005442:Flumazenil; D005680:gamma-Aminobutyric Acid; C063038:iomazenil