title: Scavenger receptor expressions in the kidneys of mice with lipoprotein glomerulopathy.
abstract: BACKGROUND
  To clarify whether dysfunction of the scavenger receptor (SR) participates in the development of lipoprotein glomerulopathy (LPG) in immunoglobulin F(c) receptor γ chain (F(c)Rγ)-deficient mice [F(c)Rγ knock-out (KO) mice] with induced chronic graft-versus-host disease (cGVHD).
  
  
  METHODS
  In wild-type (WT) and F(c)Rγ KO C57BL/6 mice, cGVHD was induced by injection of lymphoid cells from donor Bm12 mice. At 6 months after injection, the mice were sacrificed and histologically examined. Total RNA was extracted from the kidneys and cytokine, chemokine, and SR transcript expressions were evaluated by reverse transcription-polymerase chain reaction.
  
  
  RESULTS
  Three of 4 female cGVHD(+)/F(c)Rγ KO mice presented LPG in >60% of glomeruli. cGVHD(-) and cGVHD(+)/WT mice did not show LPG. The SRs CD36, CD68, and CXCL16 showed a significant difference in the values of their transcripts between cGVHD(+)/WT and cGVHD(+)/F(c)Rγ KO mice. Among them, only CD36 showed a drastic decline of mRNA expressions in cGVHD(+)/F(c)Rγ KO mice.
  
  
  CONCLUSIONS
  CD36 may play a crucial role in the development of LPG in F(c)Rγ KO mice with cGVHD. In addition to the apolipoprotein E mutation, dysfunction of lipid clearance in the kidney might be one of the factors for the development of LPG.
authors.affiliation: Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, Fukuoka, 814-0180, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nishimura
authors.forename: Maho
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Ito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D018955:CD36 Antigens / Q000096:biosynthesis*; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000378:metabolism*; D006086:Graft vs Host Disease / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000473:pathology*; D008074:Lipoproteins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000378:metabolism; D017452:Receptors, IgG / Q000172:deficiency; D051116:Receptors, Scavenger / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D018955:CD36 Antigens; D008074:Lipoproteins; D012333:RNA, Messenger; D017452:Receptors, IgG; D051116:Receptors, Scavenger
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