title: Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis.
abstract: Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (< 60 years old) and old (≥ 60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p=0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p=0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.
authors.affiliation: Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA. m.koren.michowitz@gmail.com
authors.forename: Maya
authors.initials: M
authors.lastname: Koren-Michowitz
authors.forename: Aiko
authors.initials: A
authors.lastname: Sato-Otsubo
authors.forename: Arnon
authors.initials: A
authors.lastname: Nagler
authors.forename: Torsten
authors.initials: T
authors.lastname: Haferlach
authors.forename: Seishi
authors.initials: S
authors.lastname: Ogawa
authors.forename: H Phillip
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D006801:Humans; D053208:Kaplan-Meier Estimate; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D019656:Loss of Heterozygosity; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D055815:Young Adult
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