title: Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.
abstract: Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins.
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA. matthew.hirschey@duke.edu
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hirschey
references.citation: Trends Pharmacol Sci. 2010 May;31(5):212-20
references.pmid: 20226541
references.citation: Mol Cell Proteomics. 2011 Dec;10(12):M111.012658
references.pmid: 21908771
references.citation: Cell. 2009 May 1;137(3):560-70
references.pmid: 19410549
references.citation: Nature. 2009 Jul 30;460(7255):587-91
references.pmid: 19641587
references.citation: Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8
references.pmid: 10873683
references.citation: Nat Chem Biol. 2011 Jan;7(1):58-63
references.pmid: 21151122
references.citation: Mol Cell. 2003 Feb;11(2):437-44
references.pmid: 12620231
references.citation: Cell. 2006 Sep 8;126(5):941-54
references.pmid: 16959573
references.citation: Biochem J. 1989 Aug 15;262(1):159-64
references.pmid: 2573345