title: P-selectin, E-selectin, and CD40L over time in chronic hemodialysis patients.
abstract: The aim of this study was to measure P-selectin, E-selectin, and CD-4L levels over time in chronic hemodialysis (HD) patients. Thirty stable patients with end-stage renal failure undergoing chronic HD were included in the study. Blood samples were obtained before HD for measurement of P-selectin, E-selectin, and CD-40L. Measurements were performed at month 0 (T0), 3 (T2), 8 (T3), and 13 (T4). The levels of P-selectin, E-selectin, and CD40L were also analyzed according to the occurrence of cardiovascular disease (CVD) and to CVD-related mortality. The levels of CD40L and P-selectin changed significantly over time, decreasing at month 3 and 6 and returning at the T0 levels at month 13. Conversely, E-selectin levels did not. The levels of CD40L, P-selectin and E-selectin over time did not differ significantly between patients with age ≤ 65 or > 65 years, between patients with or without CVD, or between patients who died or who survived during the follow-up. In end-stage renal failure patients undergoing chronic HD, CD40L and P-selectin, but not E-selectin, showed a transient decrease over time, and the serum levels of these molecules were not associated with CVD or with CVD-related mortality.
authors.affiliation: Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy. maubosso@tin.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bossola
authors.forename: Fausto
authors.initials: F
authors.lastname: Rosa
authors.forename: Luigi
authors.initials: L
authors.lastname: Tazza
authors.forename: Amalia
authors.initials: A
authors.lastname: de Curtis
authors.forename: Simona
authors.initials: S
authors.lastname: Costanzo
authors.forename: Carlo
authors.initials: C
authors.lastname: Vulpio
authors.forename: Licia
authors.initials: L
authors.lastname: Iacoviello
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D023201:CD40 Ligand / Q000097:blood*; D002318:Cardiovascular Diseases / Q000401:mortality; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D006435:Renal Dialysis
chemical_list: D019040:E-Selectin; D019007:P-Selectin; D023201:CD40 Ligand