title: Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck.
abstract: BACKGROUND
  We performed a retrospective review of patients with nonresected head and neck adenoid cystic carcinoma (ACC) treated with concurrent chemoradiation.
  
  
  METHODS
  Sixteen patients (nasopharynx 7, oropharynx 4, trachea 3, oral and nasal cavity 1 each) were treated at 3 tertiary care centers. Six patients received intraarterial cisplatin and 10 received intravenous cisplatin or carboplatin concurrently with radiation.
  
  
  RESULTS
  Thirteen patients are alive, 7 without signs of disease with a median follow-up of 61 months. Tumor progression was noted in 8 patients (50%) (distant metastasis in 5 patients and local tumor progression in 3 patients) with a median time to progression of 25 months (range, 4-52 months). Overall survival (OS), progression-free survival (PFS), and local progression-free survival (LPFS) rates at 5 years were 87%, 39%, and 61%, respectively.
  
  
  CONCLUSIONS
  Concurrent chemoradiation is a feasible treatment option and may lead to sustained locoregional tumor control in patients with nonresected ACC of the head and neck.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA. ssamant@uthsc.edu
authors.forename: Sandeep
authors.initials: S
authors.lastname: Samant
authors.forename: Michiel W
authors.initials: MW
authors.lastname: van den Brekel
authors.forename: Merrill S
authors.initials: MS
authors.lastname: Kies
authors.forename: Jim
authors.initials: J
authors.lastname: Wan
authors.forename: K Thomas
authors.initials: KT
authors.lastname: Robbins
authors.forename: David I
authors.initials: DI
authors.lastname: Rosenthal
authors.forename: Coen
authors.initials: C
authors.lastname: Rasch
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
mesh_terms: D000328:Adult; D000368:Aged; D016190:Carboplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy* / Q000532:radiotherapy; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D016190:Carboplatin; D002945:Cisplatin