title: Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.
abstract: During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the somatic and germ cell compartments of the ovarian follicle. The oocyte completes the meiotic cell cycle to become a fertilizable egg, and dramatic changes in gene expression and secretion take place in the somatic compartment of the follicle in preparation for follicular rupture and oocyte release. The concerted changes are regulated by activation of intracellular signaling pathways as well as paracrine and autocrine regulatory loops. This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation.
authors.affiliation: Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States. contim@obgyn.ucsf.edu
authors.forename: Marco
authors.initials: M
authors.lastname: Conti
authors.forename: Minnie
authors.initials: M
authors.lastname: Hsieh
authors.forename: A Musa
authors.initials: AM
authors.lastname: Zamah
authors.forename: Jeong Su
authors.initials: JS
authors.lastname: Oh
mesh_terms: D000818:Animals; D005260:Female; D017629:Gap Junctions / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism / Q000502:physiology; D008540:Meiosis; D009712:Nucleotides, Cyclic / Q000378:metabolism / Q000502:physiology; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D010060:Ovulation / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009712:Nucleotides, Cyclic; D043562:Receptors, G-Protein-Coupled; D007986:Luteinizing Hormone
references.citation: Reproduction. 2007 Apr;133(4):733-41
references.pmid: 17504917
references.citation: Acta Physiol Scand. 1990 Jul;139(3):511-7
references.pmid: 2173353
references.citation: J Clin Invest. 2004 Jul;114(2):196-205
references.pmid: 15254586
references.citation: Curr Opin Cell Biol. 1996 Dec;8(6):795-804
references.pmid: 8939679
references.citation: Reproduction. 2010 Nov;140(5):655-62
references.pmid: 20826538
references.citation: Endocrinology. 1987 Feb;120(2):445-9
references.pmid: 2433124
references.citation: J Exp Med. 1935 Oct 31;62(5):665-75
references.pmid: 19870440
references.citation: Dev Biol. 1984 Oct;105(2):488-99
references.pmid: 6207062
references.citation: Endocrinology. 2005 Jan;146(1):77-84
references.pmid: 15459120
references.citation: Endocrinology. 2007 Jul;148(7):3426-40
references.pmid: 17395697
references.citation: Science. 2010 Oct 15;330(6002):366-9
references.pmid: 20947764
references.citation: Dev Biol. 2003 Nov 1;263(1):126-38
references.pmid: 14568551
references.citation: Endocrinology. 2003 Feb;144(2):638-47
references.pmid: 12538627
references.citation: Exp Clin Endocrinol. 1993;101(4):262-4
references.pmid: 8307116
references.citation: Biol Reprod. 2009 Sep;81(3):595-604
references.pmid: 19474061
references.citation: Cell Differ. 1983 May;12(5):271-6
references.pmid: 6189621
references.citation: Biol Reprod. 2008 Apr;78(4):667-72
references.pmid: 18184921
references.citation: Anim Reprod Sci. 2008 Jan 15;103(1-2):187-92
references.pmid: 17507186
references.citation: Curr Top Cell Regul. 1980;16:271-311
references.pmid: 6249544
references.citation: J Cell Biol. 2005 Oct 24;171(2):255-65
references.pmid: 16247026
references.citation: Science. 2002 Aug 23;297(5585):1343-5
references.pmid: 12193786
references.citation: Endocrinology. 1998 Nov;139(11):4547-55
references.pmid: 9794464
references.citation: J Cell Biol. 1975 Dec;67(3):894-900
references.pmid: 1202027
references.citation: Hum Reprod. 1989 Apr;4(3):257-60
references.pmid: 2785532
references.citation: Mol Cell Biol. 2007 Mar;27(5):1914-24
references.pmid: 17194751
references.citation: Reproduction. 2004 Aug;128(2):153-62
references.pmid: 15280554
references.citation: Endocrinology. 2006 May;147(5):2280-6
references.pmid: 16439460
references.citation: Steroids. 2000 Oct-Nov;65(10-11):559-70
references.pmid: 11108860
references.citation: Dev Biol. 2003 Jun 15;258(2):385-96
references.pmid: 12798295
references.citation: Biol Reprod. 2001 Nov;65(5):1444-51
references.pmid: 11673261
references.citation: Endocrinology. 1985 Jan;116(1):406-9
references.pmid: 2578036
references.citation: Ann N Y Acad Sci. 1988;541:211-6
references.pmid: 2848437
references.citation: Biochem J. 1986 Sep 1;238(2):597-604
references.pmid: 3026357
references.citation: Hum Reprod. 2007 May;22(5):1247-52
references.pmid: 17293344
references.citation: Development. 2010 Apr;137(8):1297-304
references.pmid: 20223764
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8922-6
references.pmid: 15956199
references.citation: Mol Endocrinol. 2010 Feb;24(2):402-11
references.pmid: 20009084
references.citation: Cancer Res. 2009 Aug 15;69(16):6463-72
references.pmid: 19679546
references.citation: Cell Cycle. 2007 Dec 1;6(23):2902-5
references.pmid: 17993782
references.citation: J Cell Biochem. 2004 Aug 1;92(5):923-36
references.pmid: 15258916
references.citation: Hum Reprod. 2010 Oct;25(10):2569-78
references.pmid: 20719813
references.citation: Mol Cell Endocrinol. 2002 Feb 22;187(1-2):153-9
references.pmid: 11988323
references.citation: Fertil Steril. 2009 Apr;91(4):1035-41
references.pmid: 18325497
references.citation: Endocrinology. 2007 Apr;148(4):1858-67
references.pmid: 17218408
references.citation: Dev Biol. 1986 Apr;114(2):453-62
references.pmid: 2420661
references.citation: Dev Dyn. 2008 Dec;237(12):3777-86
references.pmid: 19035343
references.citation: Biol Reprod. 2006 Jan;74(1):177-84
references.pmid: 16207840
references.citation: PLoS One. 2011;6(6):e21574
references.pmid: 21738714
references.citation: Mol Endocrinol. 2010 Sep;24(9):1794-804
references.pmid: 20610537
references.citation: Dev Biol. 1996 Sep 15;178(2):393-402
references.pmid: 8812137
references.citation: Mol Endocrinol. 2007 Aug;21(8):1940-57
references.pmid: 17536007
references.citation: J Ovarian Res. 2009 Dec 24;2:20
references.pmid: 20034375
references.citation: Development. 2008 Oct;135(19):3229-38
references.pmid: 18776144
references.citation: Endocrinology. 1983 Jun;112(6):2212-4
references.pmid: 6851948
references.citation: Endocrinology. 1990 Mar;126(3):1504-8
references.pmid: 2155102
references.citation: Science. 2004 Dec 10;306(5703):1947-50
references.pmid: 15591206
references.citation: Hum Reprod. 2002 Aug;17(8):2079-84
references.pmid: 12151440
references.citation: Science. 2004 Jan 30;303(5658):682-4
references.pmid: 14726596
references.citation: Science. 2009 May 15;324(5929):938-41
references.pmid: 19443782
references.citation: Biol Reprod. 1985 Oct;33(3):698-704
references.pmid: 2996645
references.citation: Biol Reprod. 1996 Jul;55(1):111-9
references.pmid: 8793065
references.citation: J Biol Chem. 1977 Mar 10;252(5):1712-8
references.pmid: 190238
references.citation: Mol Endocrinol. 1992 Feb;6(2):272-8
references.pmid: 1314958
references.citation: J Biol Chem. 1996 Jul 12;271(28):16764-72
references.pmid: 8663226
references.citation: Biol Reprod. 1985 Nov;33(4):797-802
references.pmid: 2417636
references.citation: Hum Reprod. 1998 Aug;13(8):2199-205
references.pmid: 9756296
references.citation: Mol Endocrinol. 2008 Apr;22(4):924-36
references.pmid: 18187604
references.citation: Hum Reprod. 1999 Dec;14(12):3060-8
references.pmid: 10601097
references.citation: Proc Natl Acad Sci U S A. 1978 Sep;75(9):4369-73
references.pmid: 212746
references.citation: Curr Biol. 2005 Sep 20;15(18):1670-6
references.pmid: 16169490
references.citation: J Cell Biol. 2010 Jan 25;188(2):199-207
references.pmid: 20083600
references.citation: Development. 2009 Jun;136(11):1869-78
references.pmid: 19429786
references.citation: J Reprod Fertil. 1980 Jul;59(2):351-5
references.pmid: 6253633
references.citation: J Biol Chem. 2001 Apr 27;276(17):13957-64
references.pmid: 11278318
references.citation: Biol Reprod. 1976 Jun;14(5):511-6
references.pmid: 1276315
references.citation: Mol Endocrinol. 2011 Jan;25(1):104-16
references.pmid: 21047912
references.citation: Endocrinology. 1983 Sep;113(3):1170-2
references.pmid: 6191969
references.citation: J Clin Endocrinol Metab. 2003 May;88(5):2288-99
references.pmid: 12727988
references.citation: Theriogenology. 2005 Sep 1;64(4):902-16
references.pmid: 16054495
references.citation: Acta Physiol Scand. 1984 Dec;122(4):507-13
references.pmid: 6098139
references.citation: Mol Endocrinol. 2008 Aug;22(8):1853-65
references.pmid: 18511495
references.citation: Dev Biol. 1980 Mar 15;75(2):247-54
references.pmid: 6154623
references.citation: Nature. 1997 Feb 6;385(6616):525-9
references.pmid: 9020357
references.citation: Nat Cell Biol. 2006 May;8(5):539-40
references.pmid: 16715549
references.citation: Development. 2008 Jun;135(12):2127-37
references.pmid: 18506027
references.citation: J Biol Chem. 2009 May 1;284(18):12328-38
references.pmid: 19286662
references.citation: Nature. 1965 Oct 23;208(5008):349-51
references.pmid: 4957259
references.citation: Endocrinology. 1995 Apr;136(4):1549-58
references.pmid: 7895665
references.citation: Endocrinology. 2006 Jul;147(7):3419-27
references.pmid: 16614081
references.citation: Mol Cell Endocrinol. 2008 Mar 26;285(1-2):62-72
references.pmid: 18313839
references.citation: Dev Biol. 2005 Nov 15;287(2):249-61
references.pmid: 16229830
references.citation: J Cell Biol. 1989 Feb;108(2):595-605
references.pmid: 2537319
references.citation: Dev Biol. 2006 Nov 15;299(2):345-55
references.pmid: 16949564
references.citation: Biochem Biophys Res Commun. 2011 Feb 11;405(2):319-24
references.pmid: 21237132
references.citation: Dev Biol. 1983 Dec;100(2):287-93
references.pmid: 6317488
references.citation: J Exp Zool. 1974 Mar;187(3):383-6
references.pmid: 4362350
references.citation: Biol Reprod. 2001 Jul;65(1):188-96
references.pmid: 11420239
references.citation: Mol Pharmacol. 1990 May;37(5):671-81
references.pmid: 2160060
references.citation: Endocrinology. 2001 Jun;142(6):2184-93
references.pmid: 11356661
references.citation: J Mol Endocrinol. 2004 Aug;33(1):281-91
references.pmid: 15291759
references.citation: Dev Biol. 2002 Jun 15;246(2):441-54
references.pmid: 12051828
references.citation: Science. 2009 Nov 13;326(5955):991-4
references.pmid: 19965510
references.citation: J Endocrinol. 2008 May;197(2):409-19
references.pmid: 18434371
references.citation: J Mol Endocrinol. 2005 Apr;34(2):459-72
references.pmid: 15821110
references.citation: Biol Reprod. 2008 Jun;78(6):1111-8
references.pmid: 18337515
references.citation: Semin Reprod Med. 2009 Jan;27(1):52-61
references.pmid: 19197805
references.citation: Development. 2011 Mar;138(5):905-13
references.pmid: 21270054
references.citation: Cell Cycle. 2009 Feb 15;8(4):665-70
references.pmid: 19223768
references.citation: Mol Endocrinol. 2010 Mar;24(3):552-60
references.pmid: 20093417
references.citation: Endocrinology. 1991 Dec;129(6):3200-7
references.pmid: 1954899