title: Perioperative genomics.
abstract: Since the completion of the Human Genome Project 10 years ago, the world has witnessed an incredible progress in human genetics and genomics.(1) This progress was largely driven by the availability of better, faster and cheaper sequencing technology.(2) While it took more than 10 years and more than 1 billion dollars to complete the Human Genome Project,(3-5) an individual in the year 2011 can have his whole genome sequenced within a week for less than $30,000. With cheaper and faster sequencing came a wealth of novel discoveries which makes it timely to review how these newly found insights into the human genome are relevant for perioperative medicine. This article summarises the basics of genetic inheritance, the human genome and modern sequencing methods, as well as genetic variation and how this knowledge may be applied to patient care and research in the perioperative setting.
authors.affiliation: Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA. nagelp@wustl.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Nagele
mesh_terms: D001483:Base Sequence / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D016045:Human Genome Project; D006801:Humans; D059035:Perioperative Period
references.citation: Am J Hum Genet. 2007 Oct;81(4):768-79
references.pmid: 17847001
references.citation: N Engl J Med. 2010 Jul 8;363(2):166-76
references.pmid: 20647212
references.citation: Nature. 2011 Feb 10;470(7333):187-97
references.pmid: 21307931
references.citation: Gene. 2010 Nov 1;467(1-2):1-12
references.pmid: 20655368
references.citation: Anesthesiology. 2008 Jul;109(1):36-43
references.pmid: 18580170
references.citation: Blood. 1985 Sep;66(3):479-89
references.pmid: 2862932
references.citation: Annu Rev Biochem. 2007;76:679-99
references.pmid: 17408359
references.citation: Pharmacol Ther. 2007 Dec;116(3):496-526
references.pmid: 18001838
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19428-33
references.pmid: 18040051
references.citation: Nature. 2011 Feb 10;470(7333):198-203
references.pmid: 21307932
references.citation: Nat Rev Genet. 2009 Apr;10(4):241-51
references.pmid: 19293820
references.citation: Science. 2007 Apr 20;316(5823):445-9
references.pmid: 17363630
references.citation: Curr Atheroscler Rep. 2007 Nov;9(5):389-96
references.pmid: 18001622
references.citation: Science. 1999 Nov 19;286(5444):1488-90
references.pmid: 10610548
references.citation: Curr Opin Genet Dev. 2009 Jun;19(3):212-9
references.pmid: 19481926
references.citation: Science. 2009 Oct 9;326(5950):289-93
references.pmid: 19815776
references.citation: N Engl J Med. 2010 Dec 16;363(25):2424-33
references.pmid: 21067377
references.citation: N Engl J Med. 2008 Aug 21;359(8):789-99
references.pmid: 18650507
references.citation: Anesthesiology. 2008 Oct;109(4):707-22
references.pmid: 18813051
references.citation: Lancet. 2006 Aug 19;368(9536):704
references.pmid: 16920476
references.citation: Science. 2008 Nov 7;322(5903):881-8
references.pmid: 18988837
references.citation: Annu Rev Genomics Hum Genet. 2008;9:387-402
references.pmid: 18576944
references.citation: Drug Metab Rev. 2003 May-Aug;35(2-3):99-106
references.pmid: 12959412
references.citation: J Clin Invest. 2007 Apr;117(4):850-8
references.pmid: 17404610
references.citation: Biochim Biophys Acta. 2007 Mar;1770(3):489-94
references.pmid: 17113714
references.citation: Nat Genet. 2008 Jun;40(6):695-701
references.pmid: 18509313
references.citation: Am Heart J. 2007 Nov;154(5):815-23, 823.e1-6
references.pmid: 17967584
references.citation: JAMA. 2009 Jan 7;301(1):74-81
references.pmid: 19126812
references.citation: Nature. 2008 May 1;453(7191):56-64
references.pmid: 18451855
references.citation: Nature. 2010 Jul 15;466(7304):368-72
references.pmid: 20531469
references.citation: Curr Opin Drug Discov Devel. 2010 May;13(3):350-8
references.pmid: 20443168
references.citation: Methods Mol Biol. 2009;509:1-14
references.pmid: 19212711
references.citation: Pharmacogenet Genomics. 2009 Jul;19(7):559-62
references.pmid: 19512959
references.citation: JAMA. 2009 Jan 14;301(2):191-7
references.pmid: 19141767
references.citation: Science. 1949 Apr 29;109(2835):443
references.pmid: 18213804
references.citation: Anesthesiology. 2011 Jul;115(1):54-64
references.pmid: 21694509
references.citation: Science. 2001 Feb 16;291(5507):1304-51
references.pmid: 11181995
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):23-37
references.pmid: 14618296
references.citation: Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7
references.pmid: 271968
references.citation: N Engl J Med. 2009 Sep 10;361(11):1058-66
references.pmid: 19657110
references.citation: Nature. 2010 Oct 14;467(7317):832-8
references.pmid: 20881960
references.citation: Pharmacogenetics. 1996 Jun;6(3):193-201
references.pmid: 8807658
references.citation: Nature. 2001 Feb 15;409(6822):860-921
references.pmid: 11237011
references.citation: Nat Genet. 1995 May;10(1):111-3
references.pmid: 7647779
references.citation: Nature. 2008 Nov 6;456(7218):66-72
references.pmid: 18987736
references.citation: Trends Pharmacol Sci. 2001 Apr;22(4):195-201
references.pmid: 11282420
references.citation: Nature. 2004 Oct 21;431(7011):931-45
references.pmid: 15496913
references.citation: Pharmacogenomics. 2008 Sep;9(9):1195-206
references.pmid: 18781847
references.citation: Nature. 2008 Nov 6;456(7218):18-21
references.pmid: 18987709
references.citation: Nature. 2008 Sep 11;455(7210):232-6
references.pmid: 18668039
references.citation: Nature. 2005 Sep 1;437(7055):88-93
references.pmid: 16136132
references.citation: Pediatrics. 2010 Oct;126(4):e986-9
references.pmid: 20837591
references.citation: Clin Pharmacokinet. 2009;48(11):689-723
references.pmid: 19817501
references.citation: Br J Anaesth. 1987 Jan;59(1):3-13
references.pmid: 3548788
references.citation: Genet Res (Camb). 2010 Dec;92(5-6):371-9
references.pmid: 21429269