title: Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines.
abstract: A series of novel C-5 benzimidazolyl-2'-deoxyuridines was synthesized in good yields under solvent-free conditions and microwave irradiation from 5-formyl-2'-deoxyuridine and arylenediamine derivatives in the presence of NaHSO(3) as catalyst. Their absorption and fluorescence spectra were measured. They showed intense fluorescence around 400-500nm with quantum yields between 0.3 and 0.5. All compounds studied in this work were screened for their antibacterial activities against a series of Gram positive and negative bacteria. The trifluoromethyl substituted benzimidazole derivatives showed some antibacterial activity.
authors.affiliation: Laboratoire de Chimie Bioorganique et Macromoléculaire, Faculté des Sciences et Techniques-Guéliz, 40000 Marrakech, Morocco.
authors.forename: Jamal
authors.initials: J
authors.lastname: Krim
authors.forename: Christian
authors.initials: C
authors.lastname: Grünewald
authors.forename: Moha
authors.initials: M
authors.lastname: Taourirte
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Engels
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry*; D002384:Catalysis; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D017693:Sodium Bicarbonate / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; C061519:5-formyl-2'-deoxyuridine; D017693:Sodium Bicarbonate; C031000:benzimidazole; D003857:Deoxyuridine