title: Biotransformation of BMOV in the presence of blood serum proteins.
abstract: The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.
authors.affiliation: Istituto CNR di Chimica Biomolecolare, Trav. La Crucca 3, I-07040 Sassari, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Sanna
authors.forename: Linda
authors.initials: L
authors.lastname: Bíró
authors.forename: Péter
authors.initials: P
authors.lastname: Buglyó
authors.forename: Giovanni
authors.initials: G
authors.lastname: Micera
authors.forename: Eugenio
authors.initials: E
authors.lastname: Garribba
mesh_terms: D001711:Biotransformation; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism*; D014638:Vanadates / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D007004:Hypoglycemic Agents; D011753:Pyrones; C074212:bis(maltolato)oxovanadium(IV); D014638:Vanadates; D017027:Protein Tyrosine Phosphatases