title: Low-dose doxycycline plus additional therapies may lower systemic inflammation in postmenopausal women with periodontitis.
abstract: BACKGROUND
  The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial. Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ. J Am Dent Assoc 2011;142;262-73.
  
  
  METHODS
  Walter A. Bretz, DDS, PhD.
  
  
  OBJECTIVE
  To determine whether long-term subantimicrobial-dose-doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitis.
  
  
  BACKGROUND
  NIH/NIDCR grant R01DE012872.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Level 2: Limited-quality, patient-oriented evidence.
  
  
  METHODS
  Not applicable.
authors.affiliation: New York University, College of Dentistry, New York, NY 10010, USA. wb36@nyu.edu
authors.forename: Walter A
authors.initials: WA
authors.lastname: Bretz