title: Fabrication and material properties of fibrous PHBV scaffolds depending on the cross-ply angle for tissue engineering.
abstract: Fibrous PHBV cross-ply scaffolds were fabricated using the electrospinning technique. The electrospun fibers were arranged depending on angles of alignment, which were 180°, 90°, 60°, and 45°. The stress and strain values of the fibrous PHBV cross-ply scaffolds increased as the cross-ply angle increased. At 180°, the strength and strain values of the fibers depended on tensile loading directions. At an alignment of 90°, the PHBV scaffolds had a stress value of 3.5 MPa, which was more than two times higher than the random structure. The cell morphology and proliferation of L-929 cells was strongly dependant on the fiber alignment and the best results were observed when the angle alignment was high. The results of this study showed that the cross-ply structure of the PHBV scaffold affected not only the cell adhesion and spreading properties but also dictated the mechanical properties, which were dependent on the angles of alignment.
authors.affiliation: Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, Chungnam 330-090, Republic of Korea.
authors.forename: Yang-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Young-Ki
authors.initials: YK
authors.lastname: Min
authors.forename: Byong-Taek
authors.initials: BT
authors.lastname: Lee
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D008422:Materials Testing; D051379:Mice; D011091:Polyesters / Q000737:chemistry*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates