title: Biological aspects of angiogenesis in multiple myeloma.
abstract: Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malignant plasma cells within the bone marrow (BM). One of the hallmarks of this disease is the close interaction between myeloma cells and neighboring cells within the BM. Angiogenesis, through the activation of endothelial cells, plays an essential role in MM biology. In the current review, we describe the angiogenesis process in MM by identifying the interacting cells, the pro- and anti-angiogenic cytokines modulated, and the extracellular matrix degrading proteases liable to participate in the pathophysiology. Finally, we highlight the impact of hypoxia (through hypoxia-inducible factor-1) and constitutive activation of nuclear factor-κB in this tumor-induced neo-vascularization.
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Sart-Tilman, Belgium.
authors.forename: Eléonore
authors.initials: E
authors.lastname: Otjacques
authors.forename: Marilène
authors.initials: M
authors.lastname: Binsfeld
authors.forename: Agnes
authors.initials: A
authors.lastname: Noel
authors.forename: Yves
authors.initials: Y
authors.lastname: Beguin
authors.forename: Didier
authors.initials: D
authors.lastname: Cataldo
authors.forename: Jo
authors.initials: J
authors.lastname: Caers
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D009101:Multiple Myeloma / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines
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