title: Neurotrophic corneal ulcer after retrobulbar injection of chlorpromazine.
abstract: An 80-year-old woman with a painful, poorly seeing right eye underwent retrobulbar chlorpromazine injection for pain control. After the injection, the patient's symptoms improved; however, a neurotrophic ulcer developed within 2 weeks after the procedure. It is postulated that chlorpromazine may lead to sensory denervation to the cornea with the subsequent development of neurotrophic keratopathy, as observed in this case. Awareness of this potential adverse effect is important for proper patient safety, education, and postinjection management.
authors.affiliation: Indiana University Department of Ophthalmology, Indianapolis, Indiana, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hauck
authors.forename: Hb Harold
authors.initials: HH
authors.lastname: Lee
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Timoney
authors.forename: Yochai
authors.initials: Y
authors.lastname: Shoshani
authors.forename: William R
authors.initials: WR
authors.lastname: Nunery
mesh_terms: D000369:Aged, 80 and over; D002746:Chlorpromazine / Q000009:adverse effects*; D003315:Cornea / Q000294:innervation*; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D018492:Dopamine Antagonists / Q000009:adverse effects*; D058447:Eye Pain / Q000188:drug therapy; D005260:Female; D006801:Humans; D056965:Injections, Intraocular; D009915:Orbit; D020433:Trigeminal Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D018492:Dopamine Antagonists; D002746:Chlorpromazine