title: A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma.
abstract: Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.
authors.affiliation: Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Tamar
authors.initials: T
authors.lastname: Stone
authors.forename: Alexandra
authors.initials: A
authors.lastname: Berger
authors.forename: Sheila
authors.initials: S
authors.lastname: Blumberg
authors.forename: Daniel
authors.initials: D
authors.lastname: O'Neill
authors.forename: Frank
authors.initials: F
authors.lastname: Ross
authors.forename: Alexander
authors.initials: A
authors.lastname: McMeeking
authors.forename: Weiliam
authors.initials: W
authors.lastname: Chen
authors.forename: Irena
authors.initials: I
authors.lastname: Pastar
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002908:Chronic Disease; D003646:Debridement; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D007871:Leg Ulcer / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D015580:Mohs Surgery; D011087:Polycythemia Vera / Q000150:complications / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016038:Skin Transplantation; D014945:Wound Healing
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea
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