title: Obesity, psychiatric status, and psychiatric medications.
abstract: This article has shown that obesity is related to several psychiatric disorders, the most thoroughly researched of which is depression. In both community and clinical populations, the observed relationship is more consistent in women than in men, and is stronger in more severely obese individuals. The presence of BED also is associated with elevated risk of additional psychopathology. Longitudinal research provides evidence to support a pathway from obesity to depression, as well as one from depression to obesity. Weight loss, particularly with nonpharmacologic methods, appears to have favorable group-level effects on mood, but may be associated with adverse outcomes for some individuals. Persons who require antipsychotic medications are at risk for weight gain and metabolic abnormalities, and their management should be informed by consensus guidelines.
authors.affiliation: Children's Hospital of Philadelphia, and Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, Suite 3029, Philadelphia, PA 19104, USA.
authors.forename: Robert I
authors.initials: RI
authors.lastname: Berkowitz
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Fabricatore
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D050110:Bariatric Surgery / Q000401:mortality / Q000523:psychology; D015992:Body Mass Index; D002648:Child; D015897:Comorbidity; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000139:chemically induced; D050171:Dyslipidemias / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D015201:Meta-Analysis as Topic; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000523:psychology / Q000628:therapy; D010342:Patient Acceptance of Health Care / Q000523:psychology; D015995:Prevalence; D012196:Review Literature as Topic; D012307:Risk Factors; D012720:Severity of Illness Index; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D014150:Antipsychotic Agents