title: Piezoelectric detection of bilirubin based on bilirubin-imprinted titania film electrode.
abstract: A novel quartz crystal microbalance (QCM) sensor with a high selectivity and sensitivity has been developed for bilirubin determination, based on the modification of bilirubin-imprinted titania film onto a quartz crystal by molecular imprinting and surface sol-gel techniques. The performance of the developed bilirubin biosensor was evaluated and the results indicated that a sensitive bilirubin biosensor could be fabricated. The obtained bilirubin biosensor presents high-selectivity monitoring of bilirubin, better reproducibility, shorter response time (30 min), wider linear range (0.1-50 μM), and lower detection limit (0.05 μM). The analytical application of the bilirubin biosensor confirms the feasibility of bilirubin determination in serum sample.
authors.affiliation: Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China. zhengpengyang@yahoo.com.cn
authors.forename: Zhengpeng
authors.initials: Z
authors.lastname: Yang
authors.forename: Jinlong
authors.initials: J
authors.lastname: Yan
authors.forename: Chunjing
authors.initials: C
authors.lastname: Zhang
mesh_terms: D001663:Bilirubin / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods* / Q000706:statistics & numerical data; D055664:Electrochemical Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054802:Molecular Imprinting; D044367:Phase Transition; D058525:Quartz Crystal Microbalance Techniques; D013499:Surface Properties; D014025:Titanium
chemical_list: C009495:titanium dioxide; D014025:Titanium; D001663:Bilirubin