title: One-pot synthesis of novel 2,3-dihydro-1H-indazoles.
abstract: A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.
authors.affiliation: Department of Chemistry, Berry College, PO Box 495016, Mount Berry, GA 30101, USA. gbreton@berry.edu
authors.forename: Gary W
authors.initials: GW
authors.lastname: Breton
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Lepore
mesh_terms: D001965:Bromides / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001965:Bromides; D006834:Hydrazines; D007191:Indazoles; D003300:Copper
references.citation: Org Lett. 2007 Mar 15;9(6):973-6
references.pmid: 17311390
references.citation: J Org Chem. 2006 Apr 28;71(9):3627-9
references.pmid: 16626153
references.citation: Org Lett. 2007 Aug 30;9(18):3515-8
references.pmid: 17672471
references.citation: Org Lett. 2009 Oct 1;11(19):4354-7
references.pmid: 19731940
references.citation: Aldrichimica Acta. 2010;43(2):37-46
references.pmid: 25360052
references.citation: J Med Chem. 2009 May 14;52(9):2952-63
references.pmid: 19348472
references.citation: Beilstein J Org Chem. 2007 Mar 21;3:13
references.pmid: 17374170
references.citation: J Org Chem. 2008 Jan 18;73(2):550-7
references.pmid: 18085795