title: Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer.
abstract: Background. To our knowledge, the hormone receptor status of noncontiguous ductal carcinoma in situ (DCIS) occurring concurrently in ER/PgR-negative invasive cancer has not been studied. The current study was undertaken to investigate the ER/PgR receptor status of DCIS of the breast in patients with ER/PgR-negative invasive breast cancer. Methods. We reviewed the immunohistochemical (IHC) staining for ER and PgR of 187 consecutive cases of ER/PgR-negative invasive breast cancers, collected from 1995 to 2002. To meet the criteria for the study, we evaluated ER/PgR expression of DCIS cancer outside of the invasive breast cancer. Results. A total of 37 cases of DCIS meeting the above criteria were identified. Of these, 16 cases (43.2%) showed positive staining for ER, PgR, or both. Conclusions. In our study of ER/PgR-negative invasive breast cancer we found that in 8% of cases noncontiguous ER/PR-positive DCIS was present. In light of this finding, it may be important for pathologists to evaluate the ER/PgR status of DCIS occurring in the presence of ER/PgR-negative invasive cancer, as this subgroup could be considered for chemoprevention.
authors.affiliation: Division of Oncology/Hematology, Department of Medicine, Winthrop-University Hospital, 200 Old Country Road, Suite 450, Mineola, NY 11501, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Dobrescu
authors.forename: Monique
authors.initials: M
authors.lastname: Chang
authors.forename: Vatsala
authors.initials: V
authors.lastname: Kirtani
authors.forename: George K
authors.initials: GK
authors.lastname: Turi
authors.forename: Randa
authors.initials: R
authors.lastname: Hennawy
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Hindenburg
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