title: Heme oxygenase-1 system and gastrointestinal inflammation: a short review.
abstract: Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.
authors.affiliation: Cancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou 510095, Guangdong Province, China. bioxzhu@yahoo.com
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.forename: Wen-Guo
authors.initials: WG
authors.lastname: Fan
authors.forename: Dong-Pei
authors.initials: DP
authors.lastname: Li
authors.forename: Hsiangfu
authors.initials: H
authors.lastname: Kung
authors.forename: Marie Cm
authors.initials: MC
authors.lastname: Lin
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D001664:Biliverdine / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000201:enzymology* / Q000473:pathology*; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000473:pathology*; D007501:Iron / Q000378:metabolism; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D015854:Up-Regulation
chemical_list: D007527:Isoenzymes; D007501:Iron; D052247:Nitric Oxide Synthase Type II; D051547:Heme Oxygenase-1; D001664:Biliverdine; D001663:Bilirubin
references.citation: Dig Dis Sci. 2006 Sep;51(9):1571-81
references.pmid: 16927154
references.citation: Clin Exp Immunol. 2008 Jul;153(1):81-5
references.pmid: 18460015
references.citation: Pathol Int. 2010 Feb;60(2):93-101
references.pmid: 20398193
references.citation: Eur J Pharmacol. 2007 Apr 30;561(1-3):164-71
references.pmid: 17292349
references.citation: Annu Rev Pharmacol Toxicol. 1997;37:517-54
references.pmid: 9131263
references.citation: Trends Mol Med. 2006 Aug;12(8):348-50
references.pmid: 16829200
references.citation: Nat Med. 2002 Mar;8(3):240-6
references.pmid: 11875494
references.citation: Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G9-G14
references.pmid: 19114681
references.citation: Int J Colorectal Dis. 2007 Jun;22(6):591-9
references.pmid: 17124609
references.citation: Circ Res. 1999 Oct 15;85(8):663-71
references.pmid: 10521239
references.citation: Shock. 2009 Jan;31(1):40-9
references.pmid: 18497709
references.citation: Toxicol Appl Pharmacol. 2009 Jan 15;234(2):202-8
references.pmid: 18992762
references.citation: Eur J Pharmacol. 2008 Mar 10;581(3):315-23
references.pmid: 18215658
references.citation: Inflamm Bowel Dis. 2006 Jul;12(7):619-29
references.pmid: 16804400
references.citation: Inflamm Bowel Dis. 2003 May;9(3):179-89
references.pmid: 12792224
references.citation: Korean J Gastroenterol. 2005 May;45(5):335-9
references.pmid: 15908766
references.citation: Cell Stress Chaperones. 2003 Winter;8(4):329-34
references.pmid: 15115285
references.citation: Gastroenterology. 2003 Feb;124(2):377-91
references.pmid: 12557144
references.citation: J Clin Invest. 1999 Jan;103(1):129-35
references.pmid: 9884342
references.citation: Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G607-13
references.pmid: 15890710
references.citation: Biochem Biophys Res Commun. 2009 Dec 18;390(3):733-7
references.pmid: 19836347
references.citation: Nat Med. 2000 Apr;6(4):422-8
references.pmid: 10742149
references.citation: Biochem Pharmacol. 2007 Sep 15;74(6):870-80
references.pmid: 17678632
references.citation: Inflamm Res. 2002 Nov;51(11):522-31
references.pmid: 12540016
references.citation: Eur J Biochem. 1997 Jul 15;247(2):725-32
references.pmid: 9266719
references.citation: World J Gastroenterol. 2010 Jul 7;16(25):3112-9
references.pmid: 20593496
references.citation: Life Sci. 2001 Nov 9;69(25-26):3113-9
references.pmid: 11758836
references.citation: Gut. 2009 Mar;58(3):347-56
references.pmid: 19022916
references.citation: Cancer Res. 2006 Dec 15;66(24):11580-4
references.pmid: 17178849
references.citation: Gastroenterology. 2004 Aug;127(2):595-606
references.pmid: 15300591
references.citation: J Exp Med. 2005 Dec 19;202(12):1703-13
references.pmid: 16365149
references.citation: Free Radic Biol Med. 2009 Aug 15;47(4):381-8
references.pmid: 19414066
references.citation: Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H643-51
references.pmid: 10666097
references.citation: World J Gastroenterol. 2010 Jun 7;16(21):2633-7
references.pmid: 20518085
references.citation: Free Radic Biol Med. 2005 Jul 1;39(1):1-25
references.pmid: 15925276
references.citation: J Pathol. 2004 Nov;204(3):296-303
references.pmid: 15476266
references.citation: Inflamm Bowel Dis. 2005 Apr;11(4):350-9
references.pmid: 15803024
references.citation: World J Gastroenterol. 2006 Jul 21;12(27):4281-95
references.pmid: 16865768
references.citation: Hepatology. 2004 Dec;40(6):1333-41
references.pmid: 15565657
references.citation: Peptides. 2006 Jun;27(6):1570-6
references.pmid: 16375990
references.citation: J Gastroenterol Hepatol. 2007 Nov;22(11):1852-8
references.pmid: 17914959
references.citation: Shock. 2009 Dec;32(6):651-8
references.pmid: 19333137
references.citation: Curr Opin Pharmacol. 2009 Aug;9(4):490-500
references.pmid: 19640789
references.citation: Lancet. 1993 Aug 7;342(8867):338-40
references.pmid: 7687730
references.citation: J Pharmacol Sci. 2009 Jul;110(3):285-94
references.pmid: 19542683
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G586-94
references.pmid: 11447040
references.citation: Nat Cell Biol. 1999 Jul;1(3):152-7
references.pmid: 10559901
references.citation: Gut. 2000 Dec;47(6):771-8
references.pmid: 11076874
references.citation: FASEB J. 2003 Sep;17(12):1724-6
references.pmid: 12958189
references.citation: Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H84-93
references.pmid: 18996987
references.citation: Crit Care Med. 2005 Jun;33(6):1317-26
references.pmid: 15942350
references.citation: J Clin Biochem Nutr. 2009 Jul;45(1):9-13
references.pmid: 19590701
references.citation: J Pharmacol Exp Ther. 2009 Oct;331(1):255-64
references.pmid: 19628634
references.citation: Physiol Rev. 2006 Apr;86(2):583-650
references.pmid: 16601269
references.citation: World J Gastroenterol. 2009 Sep 21;15(35):4392-401
references.pmid: 19764090
references.citation: Clin Exp Immunol. 2005 Jun;140(3):547-55
references.pmid: 15932518
references.citation: Science. 1987 Feb 27;235(4792):1043-6
references.pmid: 3029864
references.citation: Am J Surg. 2006 Apr;191(4):503-9
references.pmid: 16531144
references.citation: J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):132-9
references.pmid: 20081544
references.citation: J Endovasc Ther. 2003 Jun;10(3):557-65
references.pmid: 12932168
references.citation: J Nutr. 2002 Sep;132(9):2570-3
references.pmid: 12221210
references.citation: J Endovasc Ther. 2001 Oct;8(5):433-40
references.pmid: 11718398
references.citation: Nat Med. 1996 Jan;2(1):87-90
references.pmid: 8564848
references.citation: J Biol Chem. 1992 Sep 5;267(25):18148-53
references.pmid: 1517245
references.citation: Trends Immunol. 2003 Aug;24(8):449-55
references.pmid: 12909459
references.citation: Scand J Gastroenterol. 2002 Jan;37(1):17-22
references.pmid: 11858169