title: Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
abstract: Osteoblast-specific gene transcription requires interaction between bone cell-specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain-leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibited through interaction with other leucine zipper proteins, intermediate filament proteins, components of the basic transcriptional machinery, nuclear matrix attachment molecules, or ubiquitously expressed transcription factors. We discuss the results supporting the relevance of these interactions and present the first evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription), and αNAC (nascent polypeptide-associated complex and coactivator alpha), three proteins that have been previously shown to associate using various protein-protein interaction assays.
authors.affiliation: Genetics Unit, Shriners Hospital for Children, Montreal, Canada. rst-arnaud@shriners.mcgill.ca
authors.forename: René
authors.initials: R
authors.lastname: St-Arnaud
authors.forename: Bahareh
authors.initials: B
authors.lastname: Hekmatnejad
mesh_terms: D051701:Activating Transcription Factor 4 / Q000235:genetics*; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D056970:Co-Repressor Proteins; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D010006:Osteoblasts / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D056970:Co-Repressor Proteins; D018832:Molecular Chaperones; D009687:Nuclear Proteins; C502605:Txlng protein, mouse; C096099:nascent-polypeptide-associated complex; D051701:Activating Transcription Factor 4
references.citation: Cell. 1993 Dec 3;75(5):875-86
references.pmid: 8252624
references.citation: Cell. 1990 Sep 21;62(6):1205-15
references.pmid: 2169352
references.citation: Cells Tissues Organs. 2009;189(1-4):144-52
references.pmid: 18728356
references.citation: Mol Carcinog. 2004 Dec;41(4):221-30
references.pmid: 15468293
references.citation: Cell. 2006 Jun 2;125(5):971-86
references.pmid: 16751105
references.citation: J Biol Chem. 1995 Mar 3;270(9):4748-52
references.pmid: 7876247
references.citation: J Clin Invest. 2009 Sep;119(9):2807-17
references.pmid: 19726872
references.citation: J Cell Biochem. 2008 Oct 15;105(3):859-65
references.pmid: 18680144
references.citation: J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):326-7
references.pmid: 18094495
references.citation: Biochemistry. 2004 Mar 16;43(10):2906-14
references.pmid: 15005626
references.citation: Gene. 2001 Jul 25;273(1):1-11
references.pmid: 11483355
references.citation: Science. 1986 Oct 3;234(4772):47-52
references.pmid: 3529394
references.citation: Gene Expr. 2002;10(5-6):255-62
references.pmid: 12450217
references.citation: Cell. 1990 Sep 21;62(6):1217-26
references.pmid: 2169353
references.citation: Biochem Biophys Res Commun. 2004 Jul 2;319(3):936-43
references.pmid: 15184072
references.citation: Bone. 2003 May;32(5):483-90
references.pmid: 12753864
references.citation: Cell. 2004 Apr 30;117(3):387-98
references.pmid: 15109498
references.citation: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4
references.pmid: 1827203
references.citation: Mol Cell Biol. 2001 Mar;21(6):2192-202
references.pmid: 11238952
references.citation: Proc Natl Acad Sci U S A. 1993 May 15;90(10):4679-83
references.pmid: 8506317
references.citation: Nature. 2005 Mar 24;434(7032):514-20
references.pmid: 15724149
references.citation: J Bone Miner Res. 2010 Nov;25(11):2489-503
references.pmid: 20564243
references.citation: Mol Cell Biol. 2002 Jul;22(13):4952-64
references.pmid: 12052899
references.citation: Mol Cell. 2003 Mar;11(3):619-33
references.pmid: 12667446
references.citation: J Biol Chem. 2009 Oct 30;284(44):30518-25
references.pmid: 19726676
references.citation: Nat Rev Cancer. 2007 Jun;7(6):454-63
references.pmid: 17522714
references.citation: J Cell Biochem. 2009 Jan 1;106(1):186-92
references.pmid: 19016261
references.citation: Ann N Y Acad Sci. 2006 Apr;1068:131-42
references.pmid: 16831913
references.citation: J Biol Chem. 2005 Sep 2;280(35):30689-96
references.pmid: 16000305
references.citation: Cell Metab. 2006 Dec;4(6):441-51
references.pmid: 17141628
references.citation: Cell Metab. 2010 Feb 3;11(2):147-60
references.pmid: 20142102
references.citation: Gene Expr. 2005;12(3):151-63
references.pmid: 16128000
references.citation: Endocr Rev. 1993 Oct;14(5):651-8
references.pmid: 8262011
references.citation: J Cell Physiol. 2006 Dec;209(3):935-42
references.pmid: 16972259
references.citation: Cell. 1990 Sep 21;62(6):1189-204
references.pmid: 2169351
references.citation: Cells Tissues Organs. 2009;189(1-4):122-5
references.pmid: 18701816
references.citation: Cell. 1995 Dec 29;83(7):1125-36
references.pmid: 8548800
references.citation: Cells Tissues Organs. 2009;189(1-4):133-7
references.pmid: 18728344
references.citation: Mol Cell Biol. 2010 Jan;30(1):43-53
references.pmid: 19884350
references.citation: Genes Dev. 2003 Dec 15;17(24):3048-61
references.pmid: 14701874
references.citation: Crit Rev Eukaryot Gene Expr. 2000;10(1):73-90
references.pmid: 10813396
references.citation: Science. 1988 Jun 24;240(4860):1759-64
references.pmid: 3289117
references.citation: Int J Mol Med. 2006 Mar;17(3):425-30
references.pmid: 16465388
references.citation: Nature. 1995 Jan 19;373(6511):257-61
references.pmid: 7816143
references.citation: Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5789-93
references.pmid: 1631061
references.citation: Bone. 2008 Jul;43(1):101-109
references.pmid: 18460422
references.citation: J Bone Miner Res. 1998 Dec;13(12):1846-51
references.pmid: 9844102
references.citation: Mol Cell Biol. 1998 Mar;18(3):1312-21
references.pmid: 9488446
references.citation: Genes Dev. 1996 Jul 15;10(14):1763-72
references.pmid: 8698236
references.citation: Biol Chem. 2008 Mar;389(3):279-83
references.pmid: 18208360
references.citation: J Biol Chem. 2004 Oct 15;279(42):43893-9
references.pmid: 15299025
references.citation: Curr Opin Cell Biol. 2008 Apr;20(2):126-36
references.pmid: 18394876
references.citation: Mol Cell Biol. 2005 May;25(9):3452-60
references.pmid: 15831452
references.citation: Genes Cells. 2005 May;10(5):465-76
references.pmid: 15836775
references.citation: Science. 1989 Mar 31;243(4899):1695-9
references.pmid: 2494702
references.citation: J Biol Chem. 2008 Feb 29;283(9):5542-53
references.pmid: 18171674
references.citation: J Biol Chem. 2004 Nov 5;279(45):47109-14
references.pmid: 15377660
references.citation: J Cell Biol. 2005 May 23;169(4):591-601
references.pmid: 15911876
references.citation: Cell. 1987 Dec 24;51(6):1079-90
references.pmid: 3319186
references.citation: Endocrinology. 1980 Nov;107(5):1494-503
references.pmid: 6968673
references.citation: Mol Biol Cell. 2008 Dec;19(12):5373-86
references.pmid: 18843047