title: Distributions of calcitonin gene-related peptide and substance P in the human maxillary sinus of Japanese cadavers.
abstract: BACKGROUND
  Substance P (SP) and calcitonin gene-related peptide (CGRP) are released by the nociceptive sensory nerve and are involved in blood flow, pain and inflammation in the nasal mucosa. The purpose of this study was to assess the distribution of the SP and CGRP nerve fibres related to blood supply within human Schneiderian membrane of the maxillary sinus (MS).
  
  
  METHODS
  In this study, the MS from Japanese cadavers was examined by whole-mount immunohistochemistry. Human male cadavers (ranging in age from 80 to 90 years) were used in this study.
  
  
  RESULTS
  SP- and CGRP-positive fibres were found around large vessels of the medialis superior alveolar branches and also within the floor region of the MS. The floor region of the MS was composed of complex branches of these fibres.
  
  
  CONCLUSIONS
  Our results give useful information for surgical sinus floor elevation in this region of the MS. These anatomical features may assist in the execution of a successful surgical procedure.
authors.affiliation: Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. iwaoa1@tokyo.ndu.ac.jp
authors.forename: Iwao
authors.initials: I
authors.lastname: Sato
authors.forename: Kosuke
authors.initials: K
authors.lastname: Imura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miwa
authors.forename: Shunji
authors.initials: S
authors.lastname: Yoshida
authors.forename: Masataka
authors.initials: M
authors.lastname: Sunohara
mesh_terms: D000369:Aged, 80 and over; D000880:Anthraquinones; D002102:Cadaver; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D004396:Coloring Agents; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008297:Male; D008438:Maxillary Artery / Q000033:anatomy & histology; D008442:Maxillary Nerve / Q000033:anatomy & histology; D008443:Maxillary Sinus / Q000033:anatomy & histology* / Q000098:blood supply / Q000294:innervation; D055806:Microvessels / Q000033:anatomy & histology; D009297:Nasal Mucosa / Q000098:blood supply / Q000294:innervation; D009412:Nerve Fibers / Q000648:ultrastructure; D013373:Substance P / Q000032:analysis*
chemical_list: D000880:Anthraquinones; D004396:Coloring Agents; D013373:Substance P; C004468:Alizarin Red S; D015740:Calcitonin Gene-Related Peptide