title: Immunossupressant and organ transplantation: immunophilins targeting agent and alternative therapies.
abstract: Since the first attempt to replace a dysfunctional organ, clinics and scientific had to overcome many setbacks in order to warrant the success and viability of both the organ and the receptor. Despite the improvement of surgical procedures, some grafts fail within the following days or week due to immunologic rejection. Many ongoing researches are still seeking the perfect immunossupresors. Calcineurin targeting agents have been consolidated as a worldwide immnunossupressant therapy, but due to its widely functional role in many cell types, this strategy often represents a highly risk therapy due to side effects observed with these agents. Here we summarized the latest and past knowledge regarding immunossupression therapies, including the promising and widely used Immunophilin-targeting antagonist therapies.
authors.affiliation: Department of renal transplantation, Infanta Cristina Hospital, Badajoz, Extremadura Spain. jcuberog@senefro.org
authors.forename: J J
authors.initials: JJ
authors.lastname: Cubero
authors.forename: E
authors.initials: E
authors.lastname: Lopez
authors.forename: P C
authors.initials: PC
authors.lastname: Redondo
authors.forename: R
authors.initials: R
authors.lastname: Alvarado
authors.forename: G
authors.initials: G
authors.lastname: Pino
authors.forename: A
authors.initials: A
authors.lastname: Cubero
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: F
authors.initials: F
authors.lastname: Ferreira
authors.forename: J
authors.initials: J
authors.lastname: Villa
authors.forename: C
authors.initials: C
authors.lastname: Martinez
mesh_terms: D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D065095:Calcineurin Inhibitors; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D020104:Immunophilins / Q000378:metabolism*; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000378:metabolism / Q000627:therapeutic use*; D016377:Organ Transplantation / Q000145:classification / Q000379:methods*
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D019703:Calcineurin; D020104:Immunophilins