title: Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review.
abstract: Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56-year-old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis.
authors.affiliation: Liver Unit, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Dwyer
authors.forename: Shahzad
authors.initials: S
authors.lastname: Sarwar
authors.forename: Brian
authors.initials: B
authors.lastname: Egan
authors.forename: Niamh
authors.initials: N
authors.lastname: Nolan
authors.forename: John
authors.initials: J
authors.lastname: Hegarty
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D001707:Biopsy, Needle; D005260:Female; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000235:genetics*; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism; D016031:Liver Transplantation / Q000009:adverse effects*; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology*; D018962:Phlebotomy / Q000379:methods; D014019:Tissue Donors
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D005293:Ferritins; D007501:Iron