title: Function of poly (lactic-co-glycolic acid) nanofiber in reduction of adhesion bands.
abstract: BACKGROUND
  In this study, we investigated the anti-adhesive and anti-inflammatory effects of electrospun nanofibrous membranes made of polycaprolactone (PCL), poly-L-lactide (PLLA), poly (lactic-co-glycolic acid) (PLGA), and polyethersulfune (PES) in comparison with the oxidized-regenerated cellulose (Interceed).
  
  
  METHODS
  Using an adhesion induction model in mice, the membranes were sutured between the abdominal wall and peritoneum after surgical operation to reveal the best membrane for prevention of postoperative adhesion bands using two scoring adhesion systems.
  
  
  RESULTS
  Compared with other membranes, PLGA, PCL, and Interceed membranes showed a greater ability to reduce adhesions. The lowest level of inflammation in adhesive tissues as well as cell attachment in vitro was detected for PLGA nanofibrous membranes.
  
  
  CONCLUSIONS
  These results suggested that in considering the FDA approved polymers, nanofibrous membranes prepared from PLGA exhibited the highest efficacy for the prevention of postoperative adhesion bands and hold promising potential for application as a new anti-adhesive agent.
authors.affiliation: Stem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Dinarvand
authors.forename: Seyed Mahmoud
authors.initials: SM
authors.lastname: Hashemi
authors.forename: Ehsan
authors.initials: E
authors.lastname: Seyedjafari
authors.forename: Iman
authors.initials: I
authors.lastname: Shabani
authors.forename: Abdollah
authors.initials: A
authors.lastname: Mohammadi-Sangcheshmeh
authors.forename: Shirin
authors.initials: S
authors.lastname: Farhadian
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
mesh_terms: D000005:Abdomen / Q000601:surgery; D000818:Animals; D002483:Cellulose, Oxidized / Q000627:therapeutic use; D019344:Lactic Acid / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D057139:Nanofibers / Q000627:therapeutic use*; D010537:Peritoneum / Q000601:surgery; D011091:Polyesters / Q000627:therapeutic use; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000627:therapeutic use; D013450:Sulfones / Q000627:therapeutic use; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED; D011091:Polyesters; D011108:Polymers; D013450:Sulfones; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; C022840:polyether sulfone; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)