title: Increased IL-17-producing CD4(+) T cells in patients with esophageal cancer.
abstract: Increased interleukin-17 (IL-17)-producing Th (Th17) cells have been described in a variety of human carcinoma cases, however, the mechanism of Th17 cells' accumulation in a tumor microenvironment remains elusive. This study was designed to investigate whether Th17 cells were involved in the development of esophageal cancer. We found that the proportion of Th17 cells increased within the peripheral blood and tumor tissues of esophageal cancer patients. Furthermore, the proportion of circulating Th17 cells was higher in advanced esophageal cancer patients than that in early esophageal cancer patients. In addition, the Th17 cells differentiation-related cytokines (IL-23, IL-1β, and IL-6) and accumulation-related chemokines (CCL22 and CCL20) were present in a tumor microenvironment. Therefore, the findings may partly explain the cause for the increased proportion of Th17 cells and indicate a potential prognostic marker of Th17 cells in esophageal cancer.
authors.affiliation: Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. cdeyu@hotmail.com
authors.forename: Deyu
authors.initials: D
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.forename: Chaoming
authors.initials: C
authors.lastname: Mao
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Jiao
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wang
authors.forename: Lichao
authors.initials: L
authors.lastname: Yu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Dongfang
authors.initials: D
authors.lastname: Dai
authors.forename: Lijia
authors.initials: L
authors.lastname: Yin
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002465:Cell Movement / Q000235:genetics / Q000276:immunology*; D054418:Chemokine CCL20 / Q000378:metabolism; D054422:Chemokine CCL22 / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000276:immunology* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D054398:Receptors, CCR4 / Q000378:metabolism; D054399:Receptors, CCR6 / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology
chemical_list: C108355:CCL20 protein, human; C515482:CCL22 protein, human; C515354:CCR4 protein, human; C106311:CCR6 protein, human; D054418:Chemokine CCL20; D054422:Chemokine CCL22; D020381:Interleukin-17; D054398:Receptors, CCR4; D054399:Receptors, CCR6