title: Pulmonary edema following scorpion envenomation: mechanisms, clinical manifestations, diagnosis and treatment.
abstract: Scorpion envenomation is common in tropical and subtropical regions. Cardio-respiratory manifestations, mainly cardiogenic shock and pulmonary edema, are the leading causes of death after scorpion envenomation. The mechanism of pulmonary edema remains unclear and contradictory conclusions were published. However, most publications confirm that pulmonary edema has been attributed to acute left ventricular failure. Cardiac failure can result from massive release of catecholamines, myocardial damage induced by the venom or myocardial ischemia. Factors usually associated with the diagnosis of pulmonary edema were young age, tachypnea, agitation, sweating, or the presence of high plasma protein concentrations. Treatment of scorpion envenomation has two components: antivenom administration and supportive care. The latter mainly targets hemodynamic impairment and cardiogenic pulmonary edema. In Latin America, and India, the use of Prazosin is recommended for treatment of pulmonary edema because pulmonary edema is associated with arterial hypertension. However, in North Africa, scorpion leads to cardiac failure with systolic dysfunction with normal vascular resistance and dobutamine was recommended. Dobutamine infusion should be used as soon as we have enough evidence suggesting the presence of pulmonary edema, since it has been demonstrated that scorpion envenomation can result in pulmonary edema secondary to acute left ventricular failure. In severe cases, mechanical ventilation can be required.
authors.affiliation: Department of Intensive Care, Habib Bourguiba University Hospital, Sfax, Tunisia. bahloulmab@yahoo.fr
authors.forename: Mabrouk
authors.initials: M
authors.lastname: Bahloul
authors.forename: Anis
authors.initials: A
authors.lastname: Chaari
authors.forename: Hassen
authors.initials: H
authors.lastname: Dammak
authors.forename: Mohamed
authors.initials: M
authors.lastname: Samet
authors.forename: Kamilia
authors.initials: K
authors.lastname: Chtara
authors.forename: Hedi
authors.initials: H
authors.lastname: Chelly
authors.forename: Chokri
authors.initials: C
authors.lastname: Ben Hamida
authors.forename: Hatem
authors.initials: H
authors.lastname: Kallel
authors.forename: Mounir
authors.initials: M
authors.lastname: Bouaziz
mesh_terms: D000997:Antivenins / Q000627:therapeutic use; D006801:Humans; D011654:Pulmonary Edema / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012121:Respiration, Artificial; D012604:Scorpion Venoms / Q000009:adverse effects*
chemical_list: D000997:Antivenins; D012604:Scorpion Venoms