title: Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11.
abstract: Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: Katrina
authors.initials: K
authors.lastname: Sleeman
authors.forename: Tiffany G
authors.initials: TG
authors.lastname: Sheu
authors.forename: Zack
authors.initials: Z
authors.lastname: Moore
authors.forename: Susan
authors.initials: S
authors.lastname: Kilpatrick
authors.forename: Shikha
authors.initials: S
authors.lastname: Garg
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Fry
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Gubareva
mesh_terms: D000146:Acids, Carbocyclic; D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D020134:Catalytic Domain / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003517:Cyclopentanes / Q000494:pharmacology / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D007223:Infant; D009981:Influenza B virus / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics*; D009657:North Carolina / Q000453:epidemiology; D053139:Oseltamivir / Q000494:pharmacology / Q000627:therapeutic use; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D053139:Oseltamivir; D009439:Neuraminidase; C414210:peramivir
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