title: The neurophysiology and pathology of brain zinc.
abstract: Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.
authors.affiliation: Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI-Center for Excellence on Aging, University "G. d'Annunzio," Chieti 66013, Italy. ssensi@uci.edu
authors.forename: Stefano L
authors.initials: SL
authors.lastname: Sensi
authors.forename: Pierre
authors.initials: P
authors.lastname: Paoletti
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Koh
authors.forename: Elias
authors.initials: E
authors.lastname: Aizenman
authors.forename: Ashley I
authors.initials: AI
authors.lastname: Bush
authors.forename: Michal
authors.initials: M
authors.lastname: Hershfinkel
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology* / Q000502:physiology; D001927:Brain Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D009482:Neurophysiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D015032:Zinc / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D015032:Zinc
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