title: Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer.
abstract: OBJECTIVE
  Heat shock proteins (HSPs) are well known as tumor rejection antigens, most notable of which is HSP70. HSP110 is classified as a member of the HSP70/DnaK superfamily. The objective of this study was to clarify the clinicopathological and prognostic significance of Heat Shock Protein 110 expression and T lymphocyte infiltration in esophageal cancer.
  
  
  METHODS
  Immunohistochemical staining of HSP110, CD4 and CD8 were performed on surgical specimens obtained from 124 patients with esophageal cancer.
  
  
  RESULTS
  The expression of HSP110 correlated inversely with depth of invasion (p<0.0001), lymph node metastasis (p=0.0163), pathological stage (p<0.0001), lymphatic invasion (p=0.0104), blood vessel invasion (p=0.0027), infiltrative growth pattern (p=0.0368) and correlated positively with CD4+ T lymphocyte infiltration (p=0.0018). Reduction of HSP110 expression was significantly correlated with poor prognosis (p=0.0010).
  
  
  CONCLUSIONS
  The present findings suggest that HSP110 expression and T lymphocyte infiltration is a significant prognostic factor for esophageal cancer.
authors.affiliation: Department of General Surgical Science, Gunma University, Gunma, Japan. mnakajim@dokkyomed.ac.jp
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakajima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Masuda
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fukai
authors.forename: Makoto
authors.initials: M
authors.lastname: Sohda
authors.forename: Takanori
authors.initials: T
authors.lastname: Inose
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sano
authors.forename: Naritaka
authors.initials: N
authors.lastname: Tanaka
authors.forename: Faried
authors.initials: F
authors.lastname: Ahmad
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D050957:HSP110 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric
chemical_list: D050957:HSP110 Heat-Shock Proteins