title: Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery.
abstract: The aim of this study was to assess the efficacy of Normast 300 mg in reducing swelling and pain after the surgical extraction of impacted lower third molars. Materials and Methods. A randomized, split-mouth, single-blind study was conducted on 30 patients between 18 and 30 years of age requiring lower third molar extraction. Patients underwent bilateral extractions in a randomized sequence, one extraction being performed under Normast treatment. The Normast treatment involved 2 tablets a day for 15 days. The parameters assessed at each procedure were trismus, swelling, pain, NSAID consumption, postoperative complications, drug tolerability, and safety. The results obtained were processed using repeated measures analysis of variance. Results. Perceived postoperative pain was reportedly significantly milder on Normast treatment than control. The trend of the means differed over time (P < .0001) and between the two extraction groups (P < .0221). On the other hand, for edema and trismus, the trend differed over time for both groups but did not differ between the two groups. Discussion. Our analyses indicate that patients experienced significantly less postoperative pain when they were treated with Normast. Conclusions. Administering Normast improves the postoperative course-in terms of pain-after lower third molar extraction.
authors.affiliation: Department of Medical and Surgical Specialities and Unit of Oral Surgery, Institute of Clinical Dentistry, University of Padua, Via Venezia, 90, 35100 Padua, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Bacci
authors.forename: Giulia
authors.initials: G
authors.lastname: Cassetta
authors.forename: Bruno
authors.initials: B
authors.lastname: Emanuele
authors.forename: Mario
authors.initials: M
authors.lastname: Berengo
references.citation: J Can Dent Assoc. 2007 May;73(4):325
references.pmid: 17484797
references.citation: Br J Oral Maxillofac Surg. 2004 Jun;42(3):209-14
references.pmid: 15121265
references.citation: Int J Oral Maxillofac Surg. 2006 Mar;35(3):241-6
references.pmid: 16188428
references.citation: Curr Med Chem. 2002 Mar;9(6):663-74
references.pmid: 11945130
references.citation: J Oral Maxillofac Surg. 2009 Jun;67(6):1206-10
references.pmid: 19446205
references.citation: J Oral Maxillofac Surg. 2010 Feb;68(2):309-12
references.pmid: 20116700
references.citation: Eur J Pharmacol. 1996 Apr 11;300(3):227-36
references.pmid: 8739213
references.citation: Eur J Pharmacol. 2009 Jun 24;613(1-3):54-9
references.pmid: 19386271
references.citation: Med Oral Patol Oral Cir Bucal. 2010 Jan 01;15(1):e74-8
references.pmid: 19767694
references.citation: Eur J Clin Pharmacol. 2006 Sep;62(9):693-8
references.pmid: 16902792
references.citation: Br J Pharmacol. 2002 Jan;135(1):181-7
references.pmid: 11786493
references.citation: Med Oral Patol Oral Cir Bucal. 2008 Aug 01;13(8):E499-504
references.pmid: 18667984
references.citation: Br J Pharmacol. 2002 Oct;137(4):413-20
references.pmid: 12359622
references.citation: Br J Pharmacol. 2007 Aug;151(7):1117-28
references.pmid: 17558434
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 May;107(5):630-40
references.pmid: 19157919
references.citation: J Oral Maxillofac Surg. 2007 Jan;65(1):83-8
references.pmid: 17174769
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov;96(5):535-9
references.pmid: 14600686
references.citation: Pain. 2008 Oct 31;139(3):541-550
references.pmid: 18602217
references.citation: Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3376-80
references.pmid: 7724569
references.citation: Med Oral Patol Oral Cir Bucal. 2005 Nov-Dec;10(5):422-31
references.pmid: 16264374
references.citation: Med Princ Pract. 2009;18(1):48-52
references.pmid: 19060491
references.citation: J Oral Maxillofac Surg. 2003 Dec;61(12):1379-89
references.pmid: 14663801