title: Influence of periodontal afferent inputs for human cerebral blood oxygenation during jaw movements.
abstract: Using functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS), we examined the role of periodontal afferent inputs on cerebral activation pattern evoked by masticatory muscle activity in twenty-two subjects. Statistical comparisons were used to identify brain regions with significant activation after subtraction of baseline activity from sham teeth-tapping (no periodontal input) and teeth-tapping (periodontal input) activity in an fMRI (N = 14) and NIRS study (N = 8). Both sham teeth-tapping and teeth-tapping significantly activated bilateral sensorimotor cortex and supplementary motor area in the fMRI study. NIRS revealed that oxygenated hemoglobin concentrations increased in sensorimotor cortex; however, there was no significant difference in degree of oxygenated hemoglobin changes between sham teeth-tapping and teeth-tapping. A control study (N = 8) characterized the jaw muscle activity and amplitude of the two motor tasks and demonstrated significantly higher electromyogram (EMG) activity in the jaw closing muscles during teeth contact in the teeth-tapping session. Since the cerebral activation during sham teeth-tapping and teeth-tapping was similar, we suggest that the influence of periodontal afferent inputs and associated jaw muscle activity is relatively minor compared to the rhythmic jaw movements. Although the clinical significance of the present findings remains unknown, they may have implications for the understanding of awake or sleep-related bruxism characterized by subconscious and rhythmic teeth-grinding or teeth-clenching.
authors.affiliation: Department of Oral Function and Rehabilitation, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-nishi, Matsudo Chiba 271-8587, Japan. iida.takashi96@nihon-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Iida
authors.forename: Masashi
authors.initials: M
authors.lastname: Sakayanagi
authors.forename: Peter
authors.initials: P
authors.lastname: Svensson
authors.forename: Osamu
authors.initials: O
authors.lastname: Komiyama
authors.forename: Teruyasu
authors.initials: T
authors.lastname: Hirayama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakatani
authors.forename: Misao
authors.initials: M
authors.lastname: Kawara
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D018737:Hand Strength; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007568:Jaw / Q000294:innervation* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008410:Masticatory Muscles / Q000502:physiology; D009068:Movement / Q000502:physiology*; D010063:Ovum; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared; D055815:Young Adult
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen
references.citation: Hum Brain Mapp. 2002 Oct;17(2):89-99
references.pmid: 12353243
references.citation: Neuroimage. 2005 Aug 1;27(1):240-6
references.pmid: 15878674
references.citation: J Prosthodont Res. 2010 Jan;54(1):48-52
references.pmid: 19837024
references.citation: Neurosci Lett. 2009 Jan 9;449(2):98-102
references.pmid: 18977413
references.citation: J Appl Physiol (1985). 2001 May;90(5):1657-62
references.pmid: 11299252
references.citation: Opt Express. 2001 Oct 8;9(8):417-27
references.pmid: 19424359
references.citation: J Prosthet Dent. 2001 Aug;86(2):195-202
references.pmid: 11514809
references.citation: J Cereb Blood Flow Metab. 2000 Mar;20(3):469-77
references.pmid: 10724111
references.citation: Exp Brain Res. 2003 Sep;152(1):42-51
references.pmid: 12830348
references.citation: Neuroimage. 2008 Oct 1;42(4):1463-72
references.pmid: 18634889
references.citation: J Oral Rehabil. 2007 Jul;34(7):487-96
references.pmid: 17559616
references.citation: J Oral Rehabil. 2009 May;36(5):346-61
references.pmid: 19382299
references.citation: Neurosci Lett. 2001 Feb 23;299(3):221-4
references.pmid: 11165775
references.citation: Eur J Oral Sci. 2008 Oct;116(5):387-93
references.pmid: 18821979
references.citation: Eur J Oral Sci. 2010 Dec;118(6):635-41
references.pmid: 21083626
references.citation: J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):182-4
references.pmid: 12122179
references.citation: J Biomed Opt. 2007 Nov-Dec;12(6):062110
references.pmid: 18163813
references.citation: Neurosci Lett. 2004 Apr 29;360(3):137-40
references.pmid: 15082152
references.citation: Neurosci Lett. 2010 Oct 4;482(3):198-202
references.pmid: 20654698
references.citation: Arch Oral Biol. 1997 Jan;42(1):57-61
references.pmid: 9134116
references.citation: Brain Res. 2011 Apr 6;1383:206-17
references.pmid: 21295015
references.citation: Exp Brain Res. 2006 Aug;173(1):165-73
references.pmid: 16489430
references.citation: J Oral Rehabil. 2009 Jun;36(6):427-34
references.pmid: 19422433
references.citation: Neuroimage. 2001 Nov;14(5):1186-92
references.pmid: 11697950
references.citation: Med Phys. 2001 Apr;28(4):521-7
references.pmid: 11339749
references.citation: J Dent Res. 2007 Jan;86(1):64-8
references.pmid: 17189465
references.citation: Magn Reson Imaging. 2010 Jun;28(5):646-52
references.pmid: 20117894
references.citation: J Oral Rehabil. 2003 Jun;30(6):614-22
references.pmid: 12787459
references.citation: J Orofac Pain. 1998 Winter;12(1):7-16
references.pmid: 9656894
references.citation: J Oral Rehabil. 2010 Dec;37(12):877-83
references.pmid: 20653828
references.citation: Neuroimage. 2004 Apr;21(4):1275-88
references.pmid: 15050555
references.citation: Cereb Cortex. 2001 Aug;11(8):773-82
references.pmid: 11459767
references.citation: J Prosthodont Res. 2011 Apr;55(2):89-97
references.pmid: 20951664
references.citation: J Prosthodont Res. 2009 Jul;53(3):126-35
references.pmid: 19345661
references.citation: Adv Exp Med Biol. 2010;662:479-84
references.pmid: 20204833
references.citation: J Dent Res. 2002 Nov;81(11):743-6
references.pmid: 12407087
references.citation: Neuroimage. 2004 Apr;21(4):1464-71
references.pmid: 15050571
references.citation: BMC Neurosci. 2007 Aug 02;8:62
references.pmid: 17678546
references.citation: J Cereb Blood Flow Metab. 1996 Sep;16(5):817-26
references.pmid: 8784226