title: Clinical course of grade I-III megaureters detected on prenatal ultrasound.
abstract: OBJECTIVE
  Primary obstructive megaureter has always been considered a developmental defect. The aim of this study was evaluate the clinical course of grade I-III megaureter at a single Institution through a longitudinal observational study.
  
  
  METHODS
  Between April 2004 and April 2006 35 cases of megaureter were observed prenatally. Inclusion criteria were created. Conservative treatment was used for all patients and its efficacy was assessed with routine laboratory tests, ultrasounds and renal scintigraphy. Follow-up was at least three years for all patients.
  
  
  RESULTS
  Twenty patients were considered for the study. Single or relapsing infections (36% of patients had more than three urinary tract infections during follow-up) did not seem absolute indications for surgical treatment in these patients, although they are currently the first indication for surgery.
  
  
  CONCLUSIONS
  Clinical results of the study showed that conservative treatment is an effective treatment option. Single or relapsing infections are not a clear indication for surgery. Long-term follow-up for these patients is mandatory.
authors.affiliation: Department of Anesthetic and Surgical Sciences, University of Verona, Verona, Italy. dr.zampieri@libero.it
authors.forename: N
authors.initials: N
authors.lastname: Zampieri
authors.forename: C
authors.initials: C
authors.lastname: Zamboni
authors.forename: F S
authors.initials: FS
authors.lastname: Camoglio
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000628:therapy; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011877:Radionuclide Imaging; D012075:Remission, Spontaneous; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal; D014513:Ureter / Q000002:abnormalities*; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents