title: Care of the infant of the diabetic mother.
abstract: Gestational diabetes mellitus (GDM) from all causes of diabetes is the most common medical complication of pregnancy and is increasing in incidence, particularly as type 2 diabetes continues to increase worldwide. Despite advances in perinatal care, infants of diabetic mothers (IDMs) remain at risk for a multitude of physiologic, metabolic, and congenital complications such as preterm birth, macrosomia, asphyxia, respiratory distress, hypoglycemia, hypocalcemia, hyperbilirubinemia, polycythemia and hyperviscosity, hypertrophic cardiomyopathy, and congenital anomalies, particularly of the central nervous system. Overt type 1 diabetes around conception produces marked risk of embryopathy (neural tube defects, cardiac defects, caudal regression syndrome), whereas later in gestation, severe and unstable type 1 maternal diabetes carries a higher risk of intrauterine growth restriction, asphyxia, and fetal death. IDMs born to mothers with type 2 diabetes are more commonly obese (macrosomic) with milder conditions of the common problems found in IDMs. IDMs from all causes of GDM also are predisposed to later-life risk of obesity, diabetes, and cardiovascular disease. Care of the IDM neonate needs to focus on ensuring adequate cardiorespiratory adaptation at birth, possible birth injuries, maintenance of normal glucose metabolism, and close observation for polycythemia, hyperbilirubinemia, and feeding intolerance.
authors.affiliation: Anschutz Medical Campus, F441, Perinatal Research Center, University of Colorado School of Medicine, 13243 East 23rd Avenue, Aurora, CO 80045, USA. bill.hay@ucdenver.edu
authors.forename: William W
authors.initials: WW
authors.lastname: Hay
mesh_terms: D000328:Adult; D001238:Asphyxia Neonatorum / Q000209:etiology / Q000628:therapy; D001720:Birth Injuries / Q000209:etiology / Q000628:therapy; D001724:Birth Weight; D000013:Congenital Abnormalities / Q000209:etiology* / Q000628:therapy*; D016640:Diabetes, Gestational; D042241:Early Diagnosis; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000628:therapy*; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D008430:Maternal-Child Health Centers; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics; D012307:Risk Factors
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