title: Serial measurement of lactate concentration in horses with acute colitis.
abstract: BACKGROUND
  Serial measurement of lactate concentration is utilized for therapeutic and prognostic purposes in human critical care. The prognostic value of serial lactate measurement in equine acute colitis warrants investigation.
  
  
  OBJECTIVE
  Serial lactate concentrations are predictive of outcome in horses with colitis.
  
  
  METHODS
  A total of 101 horses with colitis.
  
  
  METHODS
  Retrospective study. Plasma L-lactate concentrations were measured at admission and at 4-8 and 24 hours after admission. Associations between admission, early (4-8 hours) and late (24 hours) lactate concentrations, and survival status were determined. The percent reduction in lactate concentration between admission and the early time point, and between admission and the late time point, was calculated. Using a cutoff value, associations between percent reduction in lactate and survival status and associations between percent reduction in lactate and clinical and clinicopathologic data were determined.
  
  
  RESULTS
  There was no association between admission plasma lactate concentration and survival status (P = .26). The 4-8 and 24 hour after admission lactate concentrations were associated with survival status (P = .023, .013, respectively). Lactate cutoffs of ≤2.3 and ≤1.5 mmol/L had the maximum sensitivity and specificity for predicting survival at the 4-8 and 24 hour time points, respectively. When lactate reduction ≥30% at 4-8 hours and ≥50% at 24 hours after admission were used as the cutoffs, the percent reduction of lactate concentration was significantly associated with survival (P = .012 and .019, respectively).
  
  
  CONCLUSIONS
  The prognostic ability of serial measurement of blood lactate concentration warrants prospective study as a measure of therapeutic response in horses with colitis.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto-Hill
authors.forename: K G
authors.initials: KG
authors.lastname: Magdesian
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
mesh_terms: D000818:Animals; D003092:Colitis / Q000097:blood / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D007773:Lactates / Q000097:blood*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007773:Lactates