title: In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India.
abstract: OBJECTIVE
  To identify the in vitro antiplasmodial activity of seaweed plants against Plasmodium falciparumstrains.
  
  
  METHODS
  A total of eight seaweeds were collected from Kanyakumari district, Tamilnadu, India. The in vitro antiplasmodial activity was performed in 96 well plates against Plasmodium falciparum, and preliminary phytochemcial analysis were performed for the extracts.
  
  
  RESULTS
  Of the selected plants Enteromorpha intestinalis (2.61%) showed maximum percentage of extraction. The minimum concentration of inhibitory (IC50) value was observed with Chaetomorpha antennina [(26.37±4.14) μg/mL] further, the positive controls such as chloroquine and artemether showed antiplasmodial activities (IC50) with (19.10±5.93) and (6.03±0.21) μg/mL concentrations, respectively. The preliminary phytochemical analysis of the seaweed extracts showed a variety of phytochemical constituents such as carboxylic acids, phenols, protein, resins, steroids and sugars.
  
  
  CONCLUSIONS
  The antiplasmodial activity of the seaweed extract might due to the presence of sugars and phenolic compounds. From the present findings, it is concluded that, the seaweed extract of Chaetomorpha antennina can be further used as a putative antiplasmodial drugs in near future.
authors.affiliation: School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi - 623 409, Ramanathapuram District, Tamil Nadu, India. ravibiotech201321@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Ravikumar
authors.forename: G
authors.initials: G
authors.lastname: Ramanathan
authors.forename: M
authors.initials: M
authors.lastname: Gnanadesigan
authors.forename: A
authors.initials: A
authors.lastname: Ramu
authors.forename: V
authors.initials: V
authors.lastname: Vijayakumar
mesh_terms: D044724:Gracilaria / Q000737:chemistry; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D044647:Sargassum / Q000737:chemistry; D012624:Seaweed / Q000737:chemistry*; D044445:Ulva / Q000737:chemistry
chemical_list: D010936:Plant Extracts