title: 18F-DOPA PET/CT biodistribution consideration in 107 consecutive patients with neuroendocrine tumours.
abstract: OBJECTIVE
  L-6-fluoro 3,4-dihydroxyphenylalanine (18F-DOPA), an amino acid-based radiopharmaceutical, is increasingly being used in the detection and management of neuroendocrine tumours. Knowledge of the normal biodistribution of this radiopharmaceutical is essential for the proper interpretation of such studies, but the literature available is scanty due to the rarity of these tumours. The aim of this study is to evaluate the biodistribution pattern and normal variants of 18F-DOPA in a cohort of patients with neuroendocrine tumours using semiquantitative analysis (maximum standardized uptake value).
  
  
  METHODS
  We analysed 107 consecutive 18F-DOPA PET/CT studies of patients referred with medullary carcinoma of the thyroid (43), phaeochromocytoma including cases of Von Hippel Lindau syndrome and multiple endocrine neoplasia type IIA cases (34), paraganglioma (14) and other neuroendocrine tumours (16). The study population were divided into two groups: those with negative 18F-DOPA PET/CT scans (32) and those with positive scans (75). The biodistribution of 18F-DOPA in each group was measured and compared between the two groups.
  
  
  RESULTS
  The physiological biodistribution in the basal ganglia and liver parenchyma showed no variability between the two groups. Conversely, uptake in the pancreas (particularly the uncinate process) and adrenals showed considerable variability between the groups. However, these differences were found not to be significant on statistical analysis.
  
  
  CONCLUSIONS
  The data presented may provide useful information in understanding the physiologic biodistribution of DOPA and its variants, for the purpose of improving the interpretation of 18F-DOPA PET/CT.
authors.affiliation: Department of Nuclear Medicine, PET/CT Center, Santa Maria della Misericordia Hospital Rovigo, Rovigo, Italy. chondrogiannis.sotirios@azisanrovigo.it
authors.forename: Sotirios
authors.initials: S
authors.lastname: Chondrogiannis
authors.forename: Gaia
authors.initials: G
authors.lastname: Grassetto
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Marzola
authors.forename: Lucia
authors.initials: L
authors.lastname: Rampin
authors.forename: Arianna
authors.initials: A
authors.lastname: Massaro
authors.forename: Elena
authors.initials: E
authors.lastname: Bellan
authors.forename: Alice
authors.initials: A
authors.lastname: Ferretti
authors.forename: Alberto
authors.initials: A
authors.lastname: Mazza
authors.forename: Adil
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine