title: Chiral nanoporous metal-organic frameworks with high porosity as materials for drug delivery.
abstract: A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil.
authors.affiliation: Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Sun
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.forename: Chun-Gang
authors.initials: CG
authors.lastname: Wang
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Su
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Guang-Sheng
authors.initials: GS
authors.lastname: Yang
authors.forename: Kui-Zhan
authors.initials: KZ
authors.lastname: Shao
authors.forename: Ya-Qian
authors.initials: YQ
authors.lastname: Lan
authors.forename: En-Bo
authors.initials: EB
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D009942:Organometallic Compounds