title: On the benefit of magnetic magnesium nanocarrier in cardiovascular toxicity of aluminum phosphide.
abstract: The present study was designed to determine the effect of a new (25)Mg(2+)-carrying nanoparticle ((25)MgPMC16) on energy depletion, oxidative stress, and electrocardiographic (ECG) parameters on heart tissue of the rats poisoned by aluminum phosphide (AlP). (25)MgPMC16 at doses of 0.025, 0.05, and 0.1 median lethal dose (LD50 = 896 mg/kg) was administered intravenously (iv) 30 min after a single intragastric administration of AlP (0.25 LD50). Sodium bicarbonate (Bicarb; 2 mEq/kg, iv) was used as the standard therapy. After anesthesia, the animals were rapidly connected to an electronic cardiovascular monitoring device for monitoring of ECG, blood pressure (BP), and heart rate (HR). Later lipid peroxidation, antioxidant power, ATP/ADP ratio, and Mg concentration in the heart were evaluated. Results indicated that after AlP administration, BP and HR decreased while R-R duration increased. (25)MgPMC16 significantly increased the BP and HR at all doses used. We found a considerable increase in antioxidant power, Mg level in the plasma and the heart and a reduction in lipid peroxidation and ADP/ATP ratio at various doses of (25)MgPMC16, but (25)MgPMC16-0.025 + Bicarb was the most effective combination therapy. The results of this study support that (25)MgPMC16 can increase heart energy by active transport of Mg inside the cardiac cells.(25)MgPMC16 seems ameliorating AlP-induced toxicity and cardiac failure necessitating further studies.
authors.affiliation: Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Baeeri
authors.forename: Marjan
authors.initials: M
authors.lastname: Shariatpanahi
authors.forename: Amir
authors.initials: A
authors.lastname: Baghaei
authors.forename: Seyedeh Farnaz
authors.initials: SF
authors.lastname: Ghasemi-Niri
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mohammadi
authors.forename: Azadeh
authors.initials: A
authors.lastname: Mohammadirad
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Hassani
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bayrami
authors.forename: Asieh
authors.initials: A
authors.lastname: Hosseini
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Rezayat
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000284:Administration, Oral; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000493:pharmacokinetics / Q000494:pharmacology*; D008280:Magnetics; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D010720:Phosphines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D017607:Aluminum Compounds; D010720:Phosphines; D014874:Water Pollutants, Chemical; D008278:Magnesium Sulfate; C001864:aluminum phosphide