title: Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity.
abstract: A series of resorcinaren-PAMAM dendrimers with benzodiazepines in the periphery were synthesized and their anticancer properties studied. The synthesized dendrimers showed potential anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine. The dendrimers were characterized by IR, (1)H and (13)C NMR, UV-vis absorption, electrospray (ES) and/or MALDI-TOF mass spectrometries.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, C.P. 04510, México D.F., Mexico.
authors.forename: Sandra
authors.initials: S
authors.lastname: Cortez-Maya
authors.forename: Simón
authors.initials: S
authors.lastname: Hernández-Ortega
authors.forename: Teresa
authors.initials: T
authors.lastname: Ramírez-Apan
authors.forename: Irina V
authors.initials: IV
authors.lastname: Lijanova
authors.forename: Marcos
authors.initials: M
authors.lastname: Martínez-García
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D047250:Calixarenes / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D050091:Dendrimers / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; C104700:PAMAM Starburst; C466160:resorcinarene; D001569:Benzodiazepines; D047250:Calixarenes; D010649:Phenylalanine