title: Cell tropism and entry of porcine circovirus 2.
abstract: Porcine circovirus 2 (PCV2) may induce reproductive failure (return to oestrus, embryonic death, mummification, weak- and stillborn piglets) and postweaning multisystemic wasting syndrome (PMWS). Furthermore, it may modulate the immunity in such a way that it aggravates the outcome of many bacterial and viral infections. In the present paper, the cellular tropism and entry of PCV2 are described and linked with the pathological and clinical consequences.
authors.affiliation: Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. hans.nauwynck@ugent.be
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauwynck
authors.forename: R
authors.initials: R
authors.lastname: Sanchez
authors.forename: P
authors.initials: P
authors.lastname: Meerts
authors.forename: D J
authors.initials: DJ
authors.lastname: Lefebvre
authors.forename: D
authors.initials: D
authors.lastname: Saha
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: G
authors.initials: G
authors.lastname: Misinzo
mesh_terms: D000818:Animals; D018173:Circoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000472:pathogenicity*; D008954:Models, Biological; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000821:virology*; D056189:Viral Tropism; D053586:Virus Internalization