title: The enzymes of bacterial census and censorship.
abstract: N-Acyl-L-homoserine lactones (AHLs) are a major class of quorum-sensing signals used by Gram-negative bacteria to regulate gene expression in a population-dependent manner, thereby enabling group behavior. Enzymes capable of generating and catabolizing AHL signals are of significant interest for the study of microbial ecology and quorum-sensing pathways, for understanding the systems that bacteria have evolved to interact with small-molecule signals, and for their possible use in therapeutic and industrial applications. The recent structural and functional studies reviewed here provide a detailed insight into the chemistry and enzymology of bacterial communication.
authors.affiliation: Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA. waltfast@mail.utexas.edu
authors.forename: Walter
authors.initials: W
authors.lastname: Fast
authors.forename: Peter A
authors.initials: PA
authors.lastname: Tipton
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000201:enzymology* / Q000378:metabolism; D008025:Ligases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular
chemical_list: C088386:homoserine lactone; D002265:Carboxylic Ester Hydrolases; C432003:N-acyl homoserine lactonase; D008025:Ligases; C449816:N-acylhomoserine lactone synthase; D015107:4-Butyrolactone
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