title: Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum.
abstract: OBJECTIVE
  To investigate the incidence of glucose intolerance postpartum in women with gestational diabetes (GDM) and assess body weight, cholesterol and triglyceride concentrations after delivery.
  
  
  METHODS
  This was a study of an initial cohort of 100 women with GDM who were tested at 6 weeks, 6 months, and 1 year postpartum. Postpartum evaluations were glucose tolerance, weight and cholesterol and triglycerides.
  
  
  RESULTS
  Impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) was present in 36.5% of 52 participants who were assessed at 6 weeks postpartum and diabetes in 17.3%; the remaining 48 women failed to return for the 3 evaluations. By 6 months, IFG/IGT was demonstrated in 55.8% and diabetes in 32.7% of the women. At 1 year, 46.2% exhibited IFG/IGT and 48% diabetes. Moreover, the weight was higher in those women who presented IFG/IGT (75.5 ± 15.2 kg, mean ± SD) and diabetes (79.0 ± 16.2 kg) compared with those who had normal glucose tolerance (65.3 ± 14.5 kg; p < 0.05). In addition, triglycerides were higher in mothers with glucose intolerance (181.3 ± 85.9 mg/dl in IFG/IGT and 230.9 ± 90.9 mg/dl in diabetes) than in women with normal glycemia (147.8 ± 11.2 mg/dl; p < 0.05).
  
  
  CONCLUSIONS
  We demonstrated an increased incidence of women exhibiting glucose intolerance within 1 year postpartum, mainly in those who remained obese.
authors.affiliation: Endocrine Research Unit, National Medical Center, Mexican Social Security Institute, Mexico City, Mexico.
authors.forename: Renata
authors.initials: R
authors.lastname: Saucedo
authors.forename: Arturo
authors.initials: A
authors.lastname: Zarate
authors.forename: Lourdes
authors.initials: L
authors.lastname: Basurto
authors.forename: Marcelino
authors.initials: M
authors.lastname: Hernandez
authors.forename: Edgardo
authors.initials: E
authors.lastname: Puello
authors.forename: Sandra
authors.initials: S
authors.lastname: Campos
authors.forename: Erika
authors.initials: E
authors.lastname: Moreno
mesh_terms: D000328:Adult; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000209:etiology* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D049590:Postpartum Period; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol