title: Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.
abstract: OBJECTIVE
  The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients.
  
  
  METHODS
  By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n = 319) and healthy subjects (n = 1,239) were underwent.
  
  
  RESULTS
  The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p < 0.0001).
  
  
  CONCLUSIONS
  The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Yuasa-Kawase
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Taiji
authors.initials: T
authors.lastname: Yamashita
authors.forename: Ryota
authors.initials: R
authors.lastname: Kawase
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakaoka
authors.forename: Miwako
authors.initials: M
authors.lastname: Inagaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakatani
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tsubakio-Yamamoto
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohama
authors.forename: Akifumi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishida
authors.forename: Masato
authors.initials: M
authors.lastname: Ishigami
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D018955:CD36 Antigens / Q000172:deficiency*; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism; D012307:Risk Factors
chemical_list: D018955:CD36 Antigens