title: Magnetic particles in ultrasensitive biomarker protein measurements for cancer detection and monitoring.
abstract: IMPORTANCE OF THE FIELD: Devices for the reliable detection of panels of biomarker proteins facilitated by magnetic bead-based technologies have the potential to greatly improve future cancer diagnostics. The reason for this review is to highlight promising research on emerging procedures for protein capture, transport and detection featuring magnetic particles.  AREAS COVERED IN THIS REVIEW: The review covers applications of magnetic particles in protein immunoassays in emerging research and commercial methods, and stresses multiplexed protein assays for reliable future cancer diagnostics. Research literature over the past dozen years has been surveyed and specific examples are presented in detail.  EXPERT OPINION: Magnetic particles are important components of emerging protein detection systems. They need to be integrated into simple inexpensive systems for accurate, sensitive detection of fully validated panels of biomarker proteins to be widely useful in clinical cancer diagnostics.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269.
authors.forename: Vigneshwaran
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authors.lastname: Mani
authors.forename: Bhaskara V
authors.initials: BV
authors.lastname: Chikkaveeraiah
authors.forename: James F
authors.initials: JF
authors.lastname: Rusling
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