title: Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer.
abstract: The therapeutic efficacy of most drugs is greatly depends on their ability to cross the cellular barrier and reach their intracellular target sites. To transport the drugs effectively through the cellular membrane and to deliver them into the intracellular environment, several interesting smart carrier systems based on both synthetic or natural polymers have been designed and developed. In recent years, hyaluronic acid (HA) has emerged as a promising candidate for intracellular delivery of various therapeutic and imaging agents because of its innate ability to recognize specific cellular receptors that overexpressed on diseased cells. The aim of this review is to highlight the significance of HA in cancer, and to explore the recent advances of HA-based drug carriers towards cancer imaging and therapeutics.
authors.affiliation: Purdue University, Department of Biomedical Engineering, West Lafayette, IN 47907, USA.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Choi
authors.forename: Gurusamy
authors.initials: G
authors.lastname: Saravanakumar
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D003952:Diagnostic Imaging / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D058990:Molecular Targeted Therapy / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D006820:Hyaluronic Acid
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