title: Cerebral thrombosis complicating Crohn's disease: two cases.
abstract: Cerebrovenous thrombosis is quite rare in infammatory bowel disease. There are only a few reports of this association in the literature. We report 2 cases of patients with Crohn's disease (CD) who developed cerebral thrombophlebitis confirmed by neuroimaging. The first case was a 35-year-old man with a history of CD who presented with acute confusion. Brain magnetic resonance imaging demonstrated a left temporoparietal infarction and thrombosis of the left lateral sinus. Coagulation studies showed a marked protein S deficiency. His condition improved significantly after initiation of anticoagulant therapy. The second case was a 38-year-old woman who was admitted for a sudden loss of consciousness with tetraplegia. Brain computed tomography revealed a profound cerebrovenous thrombosis. She died within a few days after admission. Inflammatory bowel disease carries an increased risk of venous and arterial thrombosis. Although the pathogenic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested. In these cases, both fibrinolysis and coagulation are activated as well.
authors.affiliation: Neurology A and Neuropsychology Department, Specialities Hospital, Rabat, Morocco. laila13ma@yahoo.fr
authors.forename: Laïla
authors.initials: L
authors.lastname: Benjilali
authors.forename: Saadia
authors.initials: S
authors.lastname: Aidi
authors.forename: Hanane
authors.initials: H
authors.lastname: El Mansouri
authors.forename: Maria
authors.initials: M
authors.lastname: Benabdejlil
authors.forename: Mohamed
authors.initials: M
authors.lastname: Jiddane
authors.forename: Mostafa
authors.initials: M
authors.lastname: El Alaoui Faris
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography / Q000379:methods; D003221:Confusion / Q000209:etiology; D003424:Crohn Disease / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008297:Male; D010690:Phlebography / Q000379:methods; D018455:Protein S Deficiency / Q000150:complications; D011782:Quadriplegia / Q000209:etiology; D013924:Thrombophlebitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014474:Unconsciousness / Q000209:etiology
chemical_list: D000925:Anticoagulants