title: [Serum and urinary homocysteine in children with steroid-dependent nephrotic syndrome].
abstract: Hyperhomocysteinemia is independent risk factor of cardiovascular diseases. Similarly to nephrotic syndrome (NS) predisposes to vein thrombosis.
  
  
  OBJECTIVE
  To evaluate serum and urinary total homocysteine (stHcy and utHcy) levels in children with the symptoms of SN, and to determine a correlation between its concentration and some parameters of hemostasis, as well as doses and the time of prednisone therapy and serum cortisol level.
  
  
  METHODS
  The examined group consisted of 18 children with NS, aged 7.64 +/- 5.1 years, divided on two groups: A--in time o proteinuria; B--during treatment with prednisone after regression of proteinuria. Control group (C) consisted of 20 children, aged 8.5 +/- 3.6 years. Serum and urinary tHcy levels were assayed by enzyme-linked immunosorbent assay method using the Axis-Shield set.
  
  
  RESULTS
  Serum total Hcy concentration in groups A and B did not differ from the control group (p > 0.05). Urinary total Hcy concentration in groups A and B was significantly higher than that of control (p < 0.05). A positive correlation was observed between stHcy and serum albumin as well as cortisol levels, and between utHcy and serum AT III level.
  
  
  CONCLUSIONS
  In children with steroid-dependent NS, subclinical disturbances in hemostasis were independent of serum tHcy concentration. There was no correlation between serum tHcy and cumulated doses, as well as time of prednisone treatment, however positive correlation was found with serum cortisone. Urinary excretion of Hcy significantly increases, in comparison to control, and correlates with serum AT III level.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Klinika Pediatrii i Nefrologii. iklinped@umwb.edu.pl
authors.forename: Edyta
authors.initials: E
authors.lastname: Tenderenda
authors.forename: Agata
authors.initials: A
authors.lastname: Korzeniecka-Kozerska
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Porowski
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
authors.forename: Walentyna
authors.initials: W
authors.lastname: Zoch-Zwierz
mesh_terms: D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood* / Q000652:urine*; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000188:drug therapy* / Q000652:urine; D011241:Prednisone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D006710:Homocysteine; D011241:Prednisone