title: Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.
abstract: Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of housing complex pedigree relationships, microsatellite-based MHC typing data, as well as MHC pyrosequencing expression analysis of class I alleles. It includes a novel, automated MHC haplotype naming algorithm and has accomplished an innovative visualization protocol that allows users to view multiple familial and MHC haplotype relationships through a single, interactive graphical interface. Detailed DNA and RNA-based data can also be queried and analyzed in a highly accessible fashion, and flexible search capabilities allow experimental choices to be made based on multiple, individualized and expandable immunogenetic factors. This web application is implemented in Java, MySQL, Tomcat, and Apache, with supported browsers including Internet Explorer and Firefox on Windows and Safari on Mac OS. The software is freely available for distribution to noncommercial users by contacting Leslie.kean@emory.edu. A demonstration site for the software is available at http://typing.emory.edu/typing_demo , user name: imsdemo7@gmail.com and password: imsdemo.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Johnson
authors.forename: R D
authors.initials: RD
authors.lastname: Eady
authors.forename: S F
authors.initials: SF
authors.lastname: Ahmad
authors.forename: S
authors.initials: S
authors.lastname: Agravat
authors.forename: T
authors.initials: T
authors.lastname: Morris
authors.forename: J
authors.initials: J
authors.lastname: Else
authors.forename: S M
authors.initials: SM
authors.lastname: Lank
authors.forename: R W
authors.initials: RW
authors.lastname: Wiseman
authors.forename: D H
authors.initials: DH
authors.lastname: O'Connor
authors.forename: M C T
authors.initials: MC
authors.lastname: Penedo
authors.forename: C P
authors.initials: CP
authors.lastname: Larsen
authors.forename: L S
authors.initials: LS
authors.lastname: Kean
mesh_terms: D000465:Algorithms; D000483:Alleles; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D005838:Genotype; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D020407:Internet; D008285:Major Histocompatibility Complex / Q000235:genetics*; D018895:Microsatellite Repeats; D010375:Pedigree; D015203:Reproducibility of Results; D017422:Sequence Analysis, DNA; D012984:Software
chemical_list: D015395:Histocompatibility Antigens Class I
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