title: Palladium-catalyzed Heck-type reactions of alkyl iodides.
abstract: A palladium-catalyzed Heck-type reaction of unactivated alkyl iodides is described. This process displays broad substrate scope with respect to both alkene and alkyl iodide components and provides efficient access to a variety of cyclic products. The reaction is proposed to proceed via a hybrid organometallic-radical mechanism, facilitating the Heck-type process with alkyl halide coupling partners. Initial intermolecular studies are also reported, demonstrating the potentially wide applicability of this approach in synthesis.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors.forename: Kayla S
authors.initials: KS
authors.lastname: Bloome
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: McMahen
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Alexanian