title: Synthesis of the asperparaline core by a radical cascade.
abstract: A concise access to the pentacyclic core structure of the asperparalines is described. The key step is a radical cascade sequence comprised of a 1,6-hydrogen atom transfer followed by 6-exo-trig and 5-exo-trig cyclizations.
authors.affiliation: School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Crick
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Simpkins
authors.forename: Adrian
authors.initials: A
authors.lastname: Highton
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D005609:Free Radicals; D010879:Piperazines; D013141:Spiro Compounds; C109708:aspergillimide