title: Resolution of spatial and temporal visual attention in infants with fragile X syndrome.
abstract: Fragile X syndrome is the most common cause of inherited intellectual impairment and the most common single-gene cause of autism. Individuals with fragile X syndrome present with a neurobehavioural phenotype that includes selective deficits in spatiotemporal visual perception associated with neural processing in frontal-parietal networks of the brain. The goal of the current study was to examine whether reduced resolution of spatial and/or temporal visual attention may underlie perceptual deficits related to fragile X syndrome. Eye tracking was used to psychophysically measure the limits of spatial and temporal attention in infants with fragile X syndrome and age-matched neurotypically developing infants. Results from these experiments revealed that infants with fragile X syndrome experience drastically reduced resolution of temporal attention in a genetic dose-sensitive manner, but have a spatial resolution of attention that is not impaired. Coarse temporal attention could have significant knock-on effects for the development of perceptual, cognitive and motor abilities in individuals with the disorder.
authors.affiliation: Department of Psychology, University of California, Davis, CA 95616, USA. ffarzin@stanford.edu
authors.forename: Faraz
authors.initials: F
authors.lastname: Farzin
authors.forename: Susan M
authors.initials: SM
authors.lastname: Rivera
authors.forename: David
authors.initials: D
authors.lastname: Whitney
mesh_terms: D001288:Attention / Q000502:physiology*; D002675:Child, Preschool; D015350:Contrast Sensitivity / Q000502:physiology; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005600:Fragile X Syndrome / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests; D013028:Space Perception / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
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