title: Cross-species studies of orbitofrontal cortex and value-based decision-making.
abstract: Recent work has emphasized the role that orbitofrontal cortex (OFC) has in value-based decision-making. However, it is also clear that a number of discrepancies have arisen when comparing the findings from animal models to those from humans. Here, we examine several possibilities that might explain these discrepancies, including anatomical difference between species, the behavioral tasks used to probe decision-making and the methodologies used to assess neural function. Understanding how these differences affect the interpretation of experimental results will help us to better integrate future results from animal models. This will enable us to fully realize the benefits of using multiple approaches to understand OFC function.
authors.affiliation: Department of Psychology, University of California at Berkeley, Berkeley, California, USA. wallis@berkeley.edu
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Wallis
mesh_terms: D000818:Animals; D003657:Decision Making / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D000882:Haplorhini; D006801:Humans; D012945:Social Values
references.citation: J Comp Neurol. 1998 Nov 30;401(4):480-505
references.pmid: 9826274
references.citation: J Neurophysiol. 2009 Dec;102(6):3352-64
references.pmid: 19776363
references.citation: J Neurosci. 2011 Jul 20;31(29):10569-78
references.pmid: 21775601
references.citation: J Neurosci. 2000 Jun 1;20(11):4311-9
references.pmid: 10818166
references.citation: J Comp Neurol. 1995 Dec 25;363(4):615-641
references.pmid: 8847421
references.citation: Cereb Cortex. 2000 Mar;10(3):220-42
references.pmid: 10731218
references.citation: Nature. 2008 Jul 17;454(7202):340-4
references.pmid: 18563088
references.citation: J Neurosci. 2009 Nov 18;29(46):14617-26
references.pmid: 19923294
references.citation: J Neurosci. 2010 Jun 23;30(25):8591-601
references.pmid: 20573905
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20547-52
references.pmid: 21059901
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21767-72
references.pmid: 21118983
references.citation: J Comp Neurol. 1994 Aug 15;346(3):366-402
references.pmid: 7527805
references.citation: Science. 2003 Aug 22;301(5636):1104-7
references.pmid: 12934011
references.citation: J Neurosci. 2009 Nov 4;29(44):14004-14
references.pmid: 19890010
references.citation: J Neurosci. 2008 May 28;28(22):5623-30
references.pmid: 18509023
references.citation: Science. 2005 Apr 1;308(5718):78-83
references.pmid: 15802598
references.citation: Nature. 2008 Jun 12;453(7197):869-78
references.pmid: 18548064
references.citation: Magn Reson Med. 2001 Sep;46(3):515-22
references.pmid: 11550244
references.citation: Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17356-61
references.pmid: 20855620
references.citation: Science. 2004 Apr 9;304(5668):307-10
references.pmid: 15073380
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6010-5
references.pmid: 20231475
references.citation: Ann N Y Acad Sci. 2007 Dec;1121:54-71
references.pmid: 17698999
references.citation: Neuron. 2002 Jul 18;35(2):395-405
references.pmid: 12160756
references.citation: J Neurosci. 1999 Aug 1;19(15):6610-4
references.pmid: 10414988
references.citation: Cereb Cortex. 2000 Mar;10(3):205
references.pmid: 10731216
references.citation: Science. 2006 Sep 1;313(5791):1310-2
references.pmid: 16946075
references.citation: J Neurosci. 1995 Jul;15(7 Pt 1):4851-67
references.pmid: 7623116
references.citation: J Neurosci. 2009 Apr 8;29(14):4531-41
references.pmid: 19357278
references.citation: Neuron. 2007 Dec 6;56(5):771-83
references.pmid: 18054855
references.citation: J Neurosci. 2007 Sep 12;27(37):9984-8
references.pmid: 17855612
references.citation: Eur J Neurosci. 2003 Oct;18(7):2069-81
references.pmid: 14622240
references.citation: Annu Rev Neurosci. 2007;30:31-56
references.pmid: 17417936
references.citation: Ann N Y Acad Sci. 2007 Dec;1121:447-60
references.pmid: 17846158
references.citation: Neuron. 2006 Aug 17;51(4):509-20
references.pmid: 16908415
references.citation: J Neurosci. 2010 Sep 29;30(39):13095-104
references.pmid: 20881127
references.citation: Nature. 2009 Jan 22;457(7228):475-9
references.pmid: 19158795
references.citation: Brain. 2002 Mar;125(Pt 3):624-39
references.pmid: 11872618
references.citation: J Neurosci. 2007 Aug 1;27(31):8166-9
references.pmid: 17670960
references.citation: Science. 2007 Jan 26;315(5811):515-8
references.pmid: 17255512
references.citation: Nature. 1999 Apr 22;398(6729):704-8
references.pmid: 10227292
references.citation: J Neurosci. 2009 Feb 25;29(8):2569-74
references.pmid: 19244532
references.citation: Nat Rev Neurosci. 2006 Jul;7(7):523-34
references.pmid: 16791142
references.citation: Nat Neurosci. 2007 Dec;10(12):1625-33
references.pmid: 17982449
references.citation: J Neurosci. 2010 Dec 15;30(50):16868-75
references.pmid: 21159958
references.citation: J Neurosci. 2009 Jul 1;29(26):8388-95
references.pmid: 19571129
references.citation: Eur J Neurosci. 2010 Jun;31(12):2341-51
references.pmid: 20550569
references.citation: Learn Mem. 2007 Jun 11;14(6):446-56
references.pmid: 17562896
references.citation: J Neurosci. 2009 Jul 15;29(28):8965-76
references.pmid: 19605634
references.citation: J Neurosci. 2005 Sep 28;25(39):8854-66
references.pmid: 16192375
references.citation: J Neurosci. 2010 Jul 28;30(30):10025-38
references.pmid: 20668187
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):545-56
references.pmid: 18545266
references.citation: J Neurosci. 2009 Sep 16;29(37):11471-83
references.pmid: 19759296
references.citation: Nature. 2008 Sep 11;455(7210):227-31
references.pmid: 18690210
references.citation: Nat Neurosci. 2006 Sep;9(9):1161-8
references.pmid: 16921368
references.citation: J Neurosci. 2008 May 7;28(19):5127-38
references.pmid: 18463266
references.citation: Cognition. 1994 Apr-Jun;50(1-3):7-15
references.pmid: 8039375
references.citation: J Cogn Neurosci. 2009 Jun;21(6):1162-78
references.pmid: 18752411
references.citation: Trends Neurosci. 2008 Dec;31(12):599-608
references.pmid: 18835649
references.citation: J Neurophysiol. 2005 Oct;94(4):2457-71
references.pmid: 15958600
references.citation: J Neurosci. 2003 Oct 22;23(29):9632-8
references.pmid: 14573543
references.citation: J Comp Neurol. 1995 Dec 25;363(4):642-664
references.pmid: 8847422
references.citation: Eur J Neurosci. 2009 May;29(10):2061-73
references.pmid: 19453638
references.citation: Neuron. 2011 May 26;70(4):731-41
references.pmid: 21609828
references.citation: J Neurosci. 2009 Dec 16;29(50):15727-34
references.pmid: 20016088
references.citation: Trends Cogn Sci. 2006 Sep;10(9):424-30
references.pmid: 16899397
references.citation: Eur J Neurosci. 2010 Dec;32(11):1940-50
references.pmid: 21050280
references.citation: Neuron. 2006 Aug 17;51(4):495-507
references.pmid: 16908414
references.citation: Eur J Neurosci. 2009 Mar;29(5):1047-55
references.pmid: 19291229
references.citation: J Neurosci. 2007 Apr 11;27(15):4019-26
references.pmid: 17428979
references.citation: J Comp Neurol. 2003 Jun 2;460(3):425-49
references.pmid: 12692859
references.citation: J Neurosci. 2010 Aug 11;30(32):10799-808
references.pmid: 20702709
references.citation: J Neurosci. 2010 Feb 17;30(7):2490-5
references.pmid: 20164333
references.citation: J Neurosci. 1998 Jan 1;18(1):428-37
references.pmid: 9412519
references.citation: J Comp Neurol. 1999 Jan 11;403(2):141-57
references.pmid: 9886040
references.citation: J Comp Neurol. 1996 Jul 22;371(2):179-207
references.pmid: 8835726
references.citation: Nat Neurosci. 2001 Jan;4(1):95-102
references.pmid: 11135651
references.citation: Nature. 2001 Jul 12;412(6843):150-7
references.pmid: 11449264
references.citation: Nature. 2006 May 11;441(7090):223-6
references.pmid: 16633341
references.citation: J Neurosci. 2009 Jan 21;29(3):765-74
references.pmid: 19158302
references.citation: Neuroimage. 2009 Mar 1;45(1):143-50
references.pmid: 19071223
references.citation: Neuron. 2010 Mar 25;65(6):927-39
references.pmid: 20346766
references.citation: Neuroscience. 2009 Mar 31;159(3):1089-107
references.pmid: 19356690
references.citation: Nat Rev Neurosci. 2002 Jan;3(1):13-21
references.pmid: 11823801
references.citation: Annu Rev Neurosci. 2007;30:535-74
references.pmid: 17600525
references.citation: Annu Rev Neurosci. 2011;34:333-59
references.pmid: 21456961
references.citation: Nat Neurosci. 1998 Jun;1(2):155-9
references.pmid: 10195132
references.citation: Cereb Cortex. 2007 Nov;17(11):2669-74
references.pmid: 17259643
references.citation: Neuroimage. 2004 Mar;21(3):1155-66
references.pmid: 15006682