title: Immersion autometallographic demonstration of pathological zinc accumulation in human acute neural diseases.
abstract: Zinc is the second most prevalent trace element in the body and is present in particularly large concentrations in the mammalian brain. In animal experiments, several lines of studies show that zinc is involved in the pathological process of ischemia, epilepsy, and mechanical head trauma. However, little is known about the change of zinc in the human neural diseases. In the present study, using immersion autometallography, we found that pathological zinc accumulation was extensively present in the human neurons following ischemia, epilepsy, and mechanical head trauma. Under H&E, apparently damaged neurons were observed in all of the brain regions that showed zinc ions labeled neuronal somata. In conclusion, the data provide the evidence of an active involvement of zinc in neuronal damage.
authors.affiliation: Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, 210002 Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Wang
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Pan
mesh_terms: D000208:Acute Disease; D000328:Adult; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002648:Child; D003460:Crystallization; D005260:Female; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036103:Nanotechnology; D009422:Nervous System Diseases / Q000473:pathology*; D055815:Young Adult; D015032:Zinc / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D015032:Zinc
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