title: Prevalence and risk factors of muscle complications secondary to statins.
abstract: BACKGROUND
  The aim of the study was to investigate the prevalence and risk factors of muscle complications among patients using statins.
  
  
  METHODS
  We conducted a prospective comparative study on 345 patients receiving statins and compared the findings with an age- and gender-matched control group of 85 subjects. Univariate and multivariate analyses with logistic regression models were used to study the association of different patient and disease characteristics with muscle complications.
  
  
  RESULTS
  Adverse reactions were reported by 21% of patients and 5.9% of controls (P = 0.0013). Objective weakness was found in 15% of the patients who reported muscle symptoms (3.2% of the total cohort), but not in controls. Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing these symptoms.
  
  
  CONCLUSIONS
  Adverse reactions to statins may be more common than previously reported, and they may be affected by specific patient and disease characteristics.
authors.affiliation: Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. khalidelsalem@hotmail.com
authors.forename: Khalid
authors.initials: K
authors.lastname: El-Salem
authors.forename: Bashar
authors.initials: B
authors.lastname: Ababneh
authors.forename: Stacy
authors.initials: S
authors.lastname: Rudnicki
authors.forename: Ahmad
authors.initials: A
authors.lastname: Malkawi
authors.forename: Ali
authors.initials: A
authors.lastname: Alrefai
authors.forename: Yousef
authors.initials: Y
authors.lastname: Khader
authors.forename: Ruba
authors.initials: R
authors.lastname: Saadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saydam
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors