title: Treatment of equine sarcoid in seven Cape mountain zebra (Equus zebra zebra).
abstract: Equine sarcoid has been diagnosed in endangered Cape mountain zebra (Equus zebra zebra) in at least two game reserves in South Africa, with prevalence as high as 53% in Bontebok National Park. Seven Cape mountain zebras with sarcoids were treated with either surgical excision, 5-fluorouracil, allogenous vaccine, or a combination of 5-fluorouracil and allogenous vaccine. One of the two sarcoids on one of the 5-fluorouracil-treated zebras was left untreated. The microscopic features of the tumors evaluated showed either all or most of the typical epidermal and dermal histologic features of equine sarcoid. The zebras were examined 2 yr posttreatment to determine outcome. All sarcoids had resolved except on the zebra on which one of the sarcoids was left untreated. The efficacy of the three treatment methods in Cape mountain zebra is encouraging.
authors.affiliation: Department of Companion Animal Clinical Studies, Private Bag X04, Faculty of Veterinary Science, Onderstepoort, University of Pretoria, South Africa. johan.marais@up.ac.za
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Marais
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Page
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000662:veterinary; D056727:Endangered Species; D018397:Equidae; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D008297:Male; D012507:Sarcoidosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil