title: Bifunctional 3,3'-Ph2-BINOL-Mg catalyzed direct asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam.
abstract: Bifunctional 3,3'-Ph(2)-BINOL-Mg catalyzed direct asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam has been developed. The catalytic activity of this protocol was slightly affected by different types of Michael acceptors, such as a variety of enones as well as α,β-unsaturated N-acylpyrroles. The Michael products were obtained with high diastereoselectivities (up to 20:1) and excellent enantioselectivities (up to 98%).
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ma
authors.forename: Xu
authors.initials: X
authors.lastname: Fu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D015107:4-Butyrolactone / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D009942:Organometallic Compounds; D011758:Pyrroles; D008274:Magnesium; D015107:4-Butyrolactone