title: Cutaneous manifestations in 100 renal and reno-pancreatic recipients of Uruguay.
abstract: Uruguay is the second country of Latin America in prevalence of renal replacement therapies, including functioning kidney allografts. Long-term immunosuppressive therapy is essential for adequate graft function, but results in reduced immunosurveillance leading to an increased risk of complications such as infections and malignancies. A variety of cutaneous manifestations as well as an increase in non-melanoma skin cancers have been reported in this population. The objective of this study was to evaluate the frequency and clinical spectrum of cutaneous manifestations in renal and reno-pancreatic recipients in Uruguay. One hundred renal or reno-pancreatic recipients aged between 21- and 77-years-old were evaluated between September 2009 and September 2010. A total of 104 dermatoses were observed; 68% of the patients had at least one cutaneous manifestation. The most frequent dermatoses were cutaneous side effects due to immunosuppressive treatment (43.3%), followed by infections (27.9%), miscellaneous causes (22.1%), as well as malignant and premalignant lesions (6.7%). This is the first study evaluating dermatological complications in organ transplant recipients in our country. Most of the patients had at least one dermatological manifestation of immunosuppression, including a malignant or pre-malignant lesion, highlighting that this is a high-risk dermatological population. Cancer is one of the most important causes of death in recipients with functioning grafts. Its prevention is a major goal in the care of transplant recipients. Physicians in transplant units should be aware of the importance of dermatological screening and skin cancer surveillance.
authors.affiliation: Department of Dermatology, Hospital de Clínicas, Montevideo, Uruguay. ldufrechou@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Dufrechou
authors.forename: A
authors.initials: A
authors.lastname: Larre Borges
authors.forename: M
authors.initials: M
authors.lastname: Nin
authors.forename: L
authors.initials: L
authors.lastname: Curi
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Martínez
authors.forename: S
authors.initials: S
authors.lastname: Orihuela
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000379:methods*; D007843:Latin America; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000379:methods*; D017582:Renal Replacement Therapy / Q000379:methods; D012871:Skin Diseases / Q000209:etiology* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications / Q000209:etiology; D016896:Treatment Outcome; D014583:Uruguay
chemical_list: D007166:Immunosuppressive Agents