title: Advancing nasal reconstructive surgery: the application of tissue engineering technology.
abstract: Cartilage tissue engineering is a rapidly progressing area of regenerative medicine with advances in cell biology and scaffold engineering constantly being investigated. Many groups are now capable of making neocartilage constructs with some level of morphological, biochemical, and histological likeness to native human cartilage tissues. The application of this useful technology in articular cartilage repair is well described in the literature; however, few studies have evaluated its application in head and neck reconstruction. Although there are many studies on auricular cartilage tissue engineering, there are few studies regarding cartilage tissue engineering for complex nasal reconstruction. This study therefore highlighted the challenges involved with nasal reconstruction, with special focus on nasal cartilage tissue, and examined how advancements made in cartilage tissue engineering research could be applied to improve the clinical outcomes of total nasal reconstructive surgery.
authors.affiliation: Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London, UK.
authors.forename: Adelola
authors.initials: A
authors.lastname: Oseni
authors.forename: Claire
authors.initials: C
authors.lastname: Crowley
authors.forename: Mark
authors.initials: M
authors.lastname: Lowdell
authors.forename: Martin
authors.initials: M
authors.lastname: Birchall
authors.forename: Peter E
authors.initials: PE
authors.lastname: Butler
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Seifalian
mesh_terms: D002358:Cartilage, Articular / Q000601:surgery*; D006801:Humans; D055171:Nasal Cartilages / Q000601:surgery*; D012225:Rhinoplasty / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*