title: Implications of the Frequent Hemodialysis Network-Daily Trial.
abstract: Despite many years of experience with hemodialysis, the outcomes of maintenance dialysis patients remain poor. The Frequent Hemodialysis Network-Daily (FHN-Daily) Trial found that six times per week in-center short hemodialysis decreased left ventricular mass and improved self-reported physical functioning over a 1-year intervention period compared with conventional thrice-weekly dialysis. Despite the promising results, caution is needed in the projection of these intermediate outcomes to hard clinical endpoints, such as cardiovascular events and death.
authors.affiliation: Division of Nephrology & Hypertension, University of Utah and Salt Lake City Veterans Affairs Health Care System, Salt Lake City, Utah, USA.
authors.forename: Kalani L
authors.initials: KL
authors.lastname: Raphael
authors.forename: Alfred K
authors.initials: AK
authors.lastname: Cheung
mesh_terms: D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis / Q000379:methods* / Q000706:statistics & numerical data*