title: Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration.
abstract: Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.
authors.affiliation: WCU Hybrid Materials Program, Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
authors.forename: Tae-Sik
authors.initials: TS
authors.lastname: Jang
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Jo
authors.forename: Jong-Myeong
authors.initials: JM
authors.lastname: Jeon
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.forename: Young-Hag
authors.initials: YH
authors.lastname: Koh
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D012822:Silicon Dioxide