title: High levels of serum uric acid predict severity of coronary artery disease in patients with acute coronary syndrome.
abstract: We aimed to elucidate the relation between serum uric acid (SUA) level and severity of coronary artery disease (CAD) in nondiabetic, nonhypertensive patients (n = 246) with acute coronary syndrome (ACS). Severity of CAD was assessed by the Gensini score. One, 2, and 3 or more diseased vessels were identified in 87 (35.4%), 55 (22.4%), and 104 (42.2%) patients, respectively. Patients with hyperuricemia had higher Gensini score, high number of diseased vessels, critical lesions, and total occlusion. Serum uric acid level was significantly associated with number of diseased vessels. Serum uric acid was an independent risk factor for multivessel disease by univariate analysis. High levels of SUA associated with the severity of CAD in nondiabetic, nonhypertensive patients with ACS.
authors.affiliation: Department of Cardiology, Kayseri Education and Research Hospital, Turkey. mduran2@gmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Ozcan
authors.initials: O
authors.lastname: Orscelik
authors.forename: Deniz
authors.initials: D
authors.lastname: Elcik
authors.forename: Ayse
authors.initials: A
authors.lastname: Ocak
authors.forename: Mehmet Tugrul
authors.initials: MT
authors.lastname: Inanc
authors.forename: H Ahmet
authors.initials: HA
authors.lastname: Kasapkara
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Oguzhan
authors.forename: Namik K
authors.initials: NK
authors.lastname: Eryol
authors.forename: Ali
authors.initials: A
authors.lastname: Ergin
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D003327:Coronary Disease / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid