title: KIT and PDGFRA in esophageal pure small cell carcinoma.
abstract: The author herein reports a very rare case of pure small cell carcinoma of the esophagus with an emphasis on KIT and PDGFRA. A 72-year-old man was admitted to our hospital because of dysphagia, and endoscopy showed a tumor in the esophagus. A biopsy of the esophageal tumor showed a small cell carcinoma consisting of malignant small cells with very hyperchromatic nuclei and inconspicuous nucleoli and without any differentiations. An immuno-histochemical study revealed positive reaction for cytokeratin (Dako, Glostrup, Denmark), KIT, PDGFRA, synapto-physin, p53 protein, and CD56, and negative reaction for chromogranin, CD45, CD20, CD3, and CD30. The Ki-67 labeling was 95%. A molecular genetic analysis showed no mutations of KIT and PDGFRA genes. The patient underwent radiation (50 Gray) and chemotherapy (cisplatin, 5 courses), but he developed liver and bone metastases and died of systemic carcinomatosis five months after the initial presentation.
authors.affiliation: Department of Pathology, Shizuoka City Shimizu Hospital Shizuoka, Japan. piyo0111jp@yahoo.co.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terada
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000737:chemistry* / Q000235:genetics / Q000556:secondary / Q000628:therapy; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D004945:Esophagoscopy; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis* / Q000235:genetics; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000032:analysis* / Q000235:genetics; D017211:Treatment Failure
chemical_list: D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha
references.citation: Int J Gynecol Pathol. 2009 Jan;28(1):29-34
references.pmid: 19047911
references.citation: Int J Clin Oncol. 2010 Oct;15(5):453-6
references.pmid: 20425130
references.citation: J Gastroenterol. 2007 Dec;42(12):932-8
references.pmid: 18085349
references.citation: Oncogene. 2007 Nov 29;26(54):7560-8
references.pmid: 17546049
references.citation: Appl Immunohistochem Mol Morphol. 2005 Sep;13(3):205-20
references.pmid: 16082245
references.citation: World J Gastroenterol. 2008 Dec 21;14(47):7256-9
references.pmid: 19084944
references.citation: Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4101-8
references.pmid: 15217946
references.citation: Pathology. 2009;41(7):695-7
references.pmid: 20001354
references.citation: Oncogene. 2008 Sep 18;27(42):5624-34
references.pmid: 18521081
references.citation: Am J Surg Pathol. 2008 Jun;32(6):867-73
references.pmid: 18408593
references.citation: Hum Pathol. 2006 Dec;37(12):1527-35
references.pmid: 16996566
references.citation: J Clin Oncol. 2005 Jan 1;23(1):49-57
references.pmid: 15545668
references.citation: Am J Surg Pathol. 2007 Jan;31(1):113-20
references.pmid: 17197927
references.citation: Appl Immunohistochem Mol Morphol. 2011 Oct;19(5):450-3
references.pmid: 21403518
references.citation: Endocr Relat Cancer. 2007 Sep;14(3):853-63
references.pmid: 17914114
references.citation: Med Oncol. 2009;26(2):233-7
references.pmid: 18777214
references.citation: Int J Clin Exp Pathol. 2010 May 05;3(5):461-71
references.pmid: 20606727