title: Effect of simvastatin on the pharmacokinetics of anastrozole.
abstract: We have prospectively tested the effects of simvastatin on the pharmacokinetics of anastrozole and on estrogen concentrations in postmenopausal women with hormone receptor-positive breast cancer who were receiving adjuvant anastrozole. Following 14 days of simvastatin, we did not observe a significant change in plasma concentrations of anastrozole or hydroxyanastrozole in nine evaluable women. Likewise, we did not observe any statistically significant change in serum concentrations of either estradiol, which remained in the undetectable range, or estrone sulfate. Simvastatin and anastrozole may be safely co-administered. Pharmacokinetic results suggest that simvastatin is not likely to compromise the activity of anastrozole.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Room 144, Baltimore, MD 21231-1000, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Bao
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Blackford
authors.forename: Vered
authors.initials: V
authors.lastname: Stearns
mesh_terms: D000368:Aged; D000077384:Anastrozole; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D018931:Antineoplastic Agents, Hormonal / Q000493:pharmacokinetics*; D047072:Aromatase Inhibitors / Q000493:pharmacokinetics*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control; D004347:Drug Interactions; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009570:Nitriles / Q000097:blood / Q000493:pharmacokinetics*; D010865:Pilot Projects; D019821:Simvastatin / Q000494:pharmacology*; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000924:Anticholesteremic Agents; D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D004970:Estrone; D000077384:Anastrozole; D004958:Estradiol; D019821:Simvastatin; C017296:estrone sulfate