title: Highly enantioselective Friedel-Crafts alkylation reaction catalyzed by rosin-derived tertiary amine-thiourea: synthesis of modified chromanes with anticancer potency.
abstract: We present herein for the first time the synthesis and preliminary biological evaluation of various modified chromanes via a rosin-derived tertiary amine-thiourea-catalyzed highly enantioselective Friedel-Crafts alkylation reaction.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.forename: Lipeng
authors.initials: L
authors.lastname: Wu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Xing
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.forename: Shoulei
authors.initials: S
authors.lastname: Wang
authors.forename: Zongyao
authors.initials: Z
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D002839:Chromans; D012116:Resins, Plant; C013893:rosin; D013890:Thiourea