title: p62 at the interface of autophagy, oxidative stress signaling, and cancer.
abstract: CONCLUSIONS
  Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis.
  
  
  BACKGROUND
  Recent evidence has revealed that p62/SQSTM1 has a critical role in an oxidative stress response pathway by its direct interaction with the ubiquitin ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), which results in constitutive activation of the transcription factor NF-E2-related factor 2 (NRF2).
  
  
  RESULTS
  Both NRF2 and KEAP1 are frequently mutated in cancer. The findings just cited uncover a link between p62/SQSTM1, autophagy, and the KEAP1-NRF2 stress response pathway in tumorigenesis and shed light on the interplay between autophagy and cancer.
  
  
  CONCLUSIONS
  Here, we review the mechanisms by which p62/SQSTM1 implements its multiple roles in the regulation of tumorigenesis with emphasis on the KEAP1-NRF2 stress response signaling pathway. Uncovering the molecular mechanisms of p62/SQSTM1 function in oxidative stress signaling might contribute to elucidating its role in tumorigenesis.
authors.affiliation: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Norway. ioannis.nezis@rr-research.no
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Nezis
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D001343:Autophagy; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein