title: Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
abstract: In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide.
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.
authors.forename: Marc R
authors.initials: MR
authors.lastname: Mansour
authors.forename: A Thomas
authors.initials: AT
authors.lastname: Look