title: Growth velocity during infancy and onset of asthma in school-aged children.
abstract: BACKGROUND
  Growth velocities during infancy might affect the risk of asthma in childhood. This study examines the association between peak height and weight velocities during the first 2 years of life and onset of asthma and wheeze up to 10 years of age.
  
  
  METHODS
  Data from 9086 children who participated in the GINIplus and LISAplus birth cohorts were analyzed. Information on asthma was requested annually from 1 to 10 years and information on wheeze at 1, 2, 4, 6, and 10 years. Peak height and weight velocities were calculated using height and weight measurements obtained between birth and 2 years of age. Cox proportional hazards models and generalized linear mixed models were calculated after adjustment for potential confounding factors including birth weight and body mass index at 10 years of age.
  
  
  RESULTS
  Per interquartile range increase in peak weight velocity (PWV), the risk of asthma increased significantly (adjHR: 1.22; CI: 1.02-1.47). The relationship between peak height velocity (PHV) and onset of asthma was nonsignificant (adjHR: 1.08; CI: 0.88-1.31). Wheeze was not significantly associated with PHV or with PWV (adjOR: 1.07; CI: 0.64-1.77 and adjOR: 1.11; CI: 0.68-1.79, respectively).
  
  
  CONCLUSIONS
  Weight gain during infancy is positively associated with physician-diagnosed asthma in school-aged children.
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Flexeder
authors.forename: E
authors.initials: E
authors.lastname: Thiering
authors.forename: I
authors.initials: I
authors.lastname: Brüske
authors.forename: S
authors.initials: S
authors.lastname: Koletzko
authors.forename: C-P
authors.initials: CP
authors.lastname: Bauer
authors.forename: H-E
authors.initials: HE
authors.lastname: Wichmann
authors.forename: U
authors.initials: U
authors.lastname: Mansmann
authors.forename: A
authors.initials: A
authors.lastname: von Berg
authors.forename: D
authors.initials: D
authors.lastname: Berdel
authors.forename: U
authors.initials: U
authors.lastname: Krämer
authors.forename: B
authors.initials: B
authors.lastname: Schaaf
authors.forename: I
authors.initials: I
authors.lastname: Lehmann
authors.forename: O
authors.initials: O
authors.lastname: Herbarth
authors.forename: J
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology*; D015992:Body Mass Index; D049628:Body Size / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D057238:Growth Charts; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence