title: Soluble CD40 ligand, soluble P-selectin and von Willebrand factor levels in subjects with prediabetes: the impact of metabolic syndrome.
abstract: OBJECTIVE
  The data regarding circulating levels of markers of platelet activation and endothelial function in people with prediabetes are scant. The aim of the present study was to search blood levels of soluble CD40 ligand (sCD40L), soluble P-selectin (sP-sel) and von Willebrand Factor (vWF) in subjects with prediabetes, along with the effects of the metabolic syndrome (MetS) on these markers.
  
  
  METHODS
  A total of 77 prediabetic individuals and 81 age, sex and body mass index matched healthy subjects with normal glucose tolerance (NGT) were prospectively analyzed. Anthropometric parameters, fasting plasma glucose, blood d lipid profiles and insulin resistance indexes were determined. Plasma sCD40L, sP-sel and vWF levels were measured by ELISA.
  
  
  RESULTS
  sCD40L, sP-sel and vWF levels in the prediabetic group were similar to those in the controls. However, prediabetic subjects with the MetS had significantly higher level of sCD40L compared to those without MetS. Moreover, sCD40L level correlated significantly with waist circumference, systolic blood pressure and HDL-cholesterol level in the patient group.
  
  
  CONCLUSIONS
  These data imply that MetS may contribute, at least in part, to the mechanism of platelet activation and endothelial dysfunction in people with prediabetes.
authors.affiliation: Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey. zhgenc@yahoo.com
authors.forename: Halil
authors.initials: H
authors.lastname: Genc
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Ergun
authors.initials: E
authors.lastname: Bozoglu
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gok
authors.forename: Fatih
authors.initials: F
authors.lastname: Aslan
authors.forename: Gurkan
authors.initials: G
authors.lastname: Celebi
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erdem
authors.forename: Ferit
authors.initials: F
authors.lastname: Avcu
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Ural
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood; D004730:Endothelium, Vascular / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation; D014841:von Willebrand Factor / Q000096:biosynthesis*
chemical_list: D019007:P-Selectin; D014841:von Willebrand Factor; D023201:CD40 Ligand