title: Combined optical and acoustical detection of single microbubble dynamics.
abstract: A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.
authors.affiliation: Physics of Fluids Group and MIRA Institute of Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Sijl
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Vos
authors.forename: Timo
authors.initials: T
authors.lastname: Rozendal
authors.forename: Nico
authors.initials: N
authors.lastname: de Jong
authors.forename: Detlef
authors.initials: D
authors.lastname: Lohse
authors.forename: Michel
authors.initials: M
authors.lastname: Versluis
mesh_terms: D003287:Contrast Media; D005466:Fluorocarbons; D016014:Linear Models; D045423:Microbubbles; D017711:Nonlinear Dynamics; D009991:Oscillometry; D010316:Particle Size; D010743:Phospholipids; D010784:Photomicrography / Q000295:instrumentation; D011312:Pressure; D012815:Signal Processing, Computer-Assisted; D013499:Surface Properties; D013997:Time Factors; D014159:Transducers; D014465:Ultrasonics / Q000295:instrumentation
chemical_list: C471302:BR14 contrast agent; D003287:Contrast Media; D005466:Fluorocarbons; D010743:Phospholipids