title: Synthesis and biological activity of dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazins.
abstract: Reaction of 2-guanidinobenzimidazole with halogenated active methylenes and ketones gave dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo [1,2-a][1,3,5]triazin derivatives in very good yield. The anti-bacterial evaluation of the newly synthesized products against broad spectrum of bacteria was performed. Most of products showed high inhibitory effect. All compounds have been characterized based on IR, (1)H NMR, (13)C NMR and Mass spectra.
authors.affiliation: Department of Chemistry, Sohag University, 82524 Sohag, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Soliman
authors.forename: Shaaban K
authors.initials: SK
authors.lastname: Mohamed
authors.forename: Mahmoud A A
authors.initials: MA
authors.lastname: El Remaily
authors.forename: H
authors.initials: H
authors.lastname: Abdel-Ghany
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D014227:Triazines; C029899:imidazole