title: Compatibility of different polymers for cord blood-derived hematopoietic progenitor cells.
abstract: The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility.
authors.affiliation: Institute of Pathology, RWTH Aachen University, Aachen, Germany. mventuraferreira@ukaachen.de
authors.forename: Mónica Ventura
authors.initials: MV
authors.lastname: Ferreira
authors.forename: Norina
authors.initials: N
authors.lastname: Labude
authors.forename: Daniela
authors.initials: D
authors.lastname: Piroth
authors.forename: Willi
authors.initials: W
authors.lastname: Jahnen-Dechent
authors.forename: Ruth
authors.initials: R
authors.lastname: Knüchel
authors.forename: Thomas
authors.initials: T
authors.lastname: Hieronymus
authors.forename: Martin
authors.initials: M
authors.lastname: Zenke
authors.forename: Sabine
authors.initials: S
authors.lastname: Neuss
mesh_terms: D018952:Antigens, CD34 / Q000276:immunology; D017209:Apoptosis; D001672:Biocompatible Materials; D049109:Cell Proliferation; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D011108:Polymers / Q000737:chemistry*
chemical_list: D018952:Antigens, CD34; D001672:Biocompatible Materials; D011108:Polymers
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