title: Near-infrared autofluorescence and indocyanine green angiography in central serous chorioretinopathy.
abstract: OBJECTIVE
  To evaluate the diagnostic potential of near-infrared (NIR) autofluorescence (AF) in central serous chorioretinopathy (CSC) and to present a method to analyze NIR-AF findings quantitatively.
  
  
  METHODS
  NIR-AF images, indocyanine green (ICG) angiograms, blue-light autofluorescence (BL-AF) images and fluorescein angiograms were recorded with the use of a confocal scanning laser ophthalmoscope in 19 eyes of 17 patients with CSC. Gray-value ratios were calculated to compare the methods.
  
  
  RESULTS
  Using NIR-AF, hypofluorescent spots were observed at the leakage site in 18 of 19 eyes (94.7%). The mean gray-value ratio (±SD) was 0.55 ± 0.22 for the site of the leakage point with NIR-AF and 0.65 ± 0.35 with BL-AF. ICG angiography showed a gray-value ratio of 2.37 ± 2.07. Fluorescein angiography had the best contrast, with a gray-value ratio of 13.44 ± 15.02.
  
  
  CONCLUSIONS
  NIR-AF demonstrated CSC in 94.7% of the cases. NIR-AF may be a noninvasive alternative to detect CSC.
authors.affiliation: Department of Ophthalmology, General Hospital Klagenfurt, Klagenfurt, Austria. ewald.lindner@lkh-klu.at
authors.forename: E
authors.initials: E
authors.lastname: Lindner
authors.forename: A
authors.initials: A
authors.lastname: Weinberger
authors.forename: T
authors.initials: T
authors.lastname: Kirschkamp
authors.forename: Y
authors.initials: Y
authors.lastname: El-Shabrawi
authors.forename: A
authors.initials: A
authors.lastname: Barounig
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D009887:Ophthalmoscopy
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green