title: Preparation of shape-persistent macrocycles with a single pyridine unit by double cross-coupling reactions of aryl bromides and alkynes.
abstract: A double Sonogashira-type coupling reaction between aryl bromides and alkynes using a catalytic Pd/XPhos (2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl) system was introduced as an efficient method for the synthesis of shape-persistent macrocycles (SPMs). This approach is advantageous in the synthesis of SPMs with a single pyridine unit.
authors.affiliation: Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka Shinjuku, Tokyo, Japan 162-8601. yamaryu@rs.kagu.tus.ac.jp
authors.forename: Ryu
authors.initials: R
authors.lastname: Yamasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shigeto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Saito