title: Computer-based route-definition system for peripheral bronchoscopy.
abstract: Multi-detector computed tomography (MDCT) scanners produce high-resolution images of the chest. Given a patient's MDCT scan, a physician can use an image-guided intervention system to first plan and later perform bronchoscopy to diagnostic sites situated deep in the lung periphery. An accurate definition of complete routes through the airway tree leading to the diagnostic sites, however, is vital for avoiding navigation errors during image-guided bronchoscopy. We present a system for the robust definition of complete airway routes suitable for image-guided bronchoscopy. The system incorporates both automatic and semiautomatic MDCT analysis methods for this purpose. Using an intuitive graphical user interface, the user invokes automatic analysis on a patient's MDCT scan to produce a series of preliminary routes. Next, the user visually inspects each route and quickly corrects the observed route defects using the built-in semiautomatic methods. Application of the system to a human study for the planning and guidance of peripheral bronchoscopy demonstrates the efficacy of the system.
authors.affiliation: Department of Electrical Engineering, Penn State University, University Park, Pennsylvania, PA 16802, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Graham
authors.forename: Jason D
authors.initials: JD
authors.lastname: Gibbs
authors.forename: William E
authors.initials: WE
authors.lastname: Higgins
mesh_terms: D000465:Algorithms; D001995:Bronchography / Q000379:methods*; D001999:Bronchoscopy / Q000379:methods*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015641:Radiography, Interventional / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014584:User-Computer Interface
references.citation: Comput Biol Med. 2009 Mar;39(3):266-79
references.pmid: 19217089
references.citation: IEEE Trans Med Imaging. 2010 Apr;29(4):982-97
references.pmid: 20335095
references.citation: J Digit Imaging. 2010 Feb;23(1):39-50
references.pmid: 19050956
references.citation: Chest. 1994 Jun;105(6):1658-62
references.pmid: 8205857
references.citation: Chest. 2008 Nov;134(5):1017-1026
references.pmid: 18583513
references.citation: Acad Radiol. 2002 Oct;9(10):1153-68
references.pmid: 12385510
references.citation: Chest. 2000 Oct;118(4):936-9
references.pmid: 11035659
references.citation: Chest. 2006 Apr;129(4):988-94
references.pmid: 16608948
references.citation: Am J Respir Crit Care Med. 2006 Nov 1;174(9):961-2
references.pmid: 17060664
references.citation: Am J Respir Crit Care Med. 2010 Sep 1;182(5):589-97
references.pmid: 20378726
references.citation: Radiographics. 2005 Sep-Oct;25(5):1409-28
references.pmid: 16160120
references.citation: Clin Chest Med. 1999 Mar;20(1):201-17
references.pmid: 10205726
references.citation: Radiographics. 1998 May-Jun;18(3):761-78
references.pmid: 9599397
references.citation: Chest. 2007 Feb;131(2):549-53
references.pmid: 17296660
references.citation: AJR Am J Roentgenol. 1984 Jan;142(1):47-52
references.pmid: 6606964
references.citation: IEEE Trans Med Imaging. 2000 Feb;19(2):103-14
references.pmid: 10784282
references.citation: Radiology. 1996 Sep;200(3):857-62
references.pmid: 8756944
references.citation: Chest. 2004 Sep;126(3):748-54
references.pmid: 15364752
references.citation: Chest. 2008 Apr;133(4):897-905
references.pmid: 18263679
references.citation: Comput Med Imaging Graph. 2008 Apr;32(3):159-73
references.pmid: 18096365
references.citation: Lung Cancer. 2008 Jun;60(3):366-73
references.pmid: 18055063
references.citation: Chest. 2006 Aug;130(2):559-66
references.pmid: 16899859
references.citation: Lung Cancer. 2007 May;56(2):201-6
references.pmid: 17229486
references.citation: IEEE Trans Med Imaging. 2004 Nov;23(11):1353-64
references.pmid: 15554124
references.citation: Clin Chest Med. 2010 Mar;31(1):75-85, Table of Contents
references.pmid: 20172434
references.citation: J Med Invest. 2004 Aug;51(3-4):163-70
references.pmid: 15460902
references.citation: IEEE Trans Med Imaging. 2003 Aug;22(8):940-50
references.pmid: 12906248