title: New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer.
abstract: Prostate cancer is the most commonly diagnosed cancer and second most common cause of cancer deaths in American men. Its long latency, slow progression, and high incidence rate make prostate cancer ideal for targeted chemopreventative therapies. Therefore, chemoprevention studies and clinical trials are essential for reducing the burden of prostate cancer on society. Epidemiological studies suggest that tea consumption has protective effects against a variety of human cancers, including that of the prostate. Laboratory and clinical studies have demonstrated that green tea components, specifically the green tea catechin (GTC) epigallocatechin gallate, can induce apoptosis, suppress progression, and inhibit invasion and metastasis of prostate cancer. Multiple mechanisms are involved in the chemoprevention of prostate cancer with GTCs; understanding and refining models of fundamental molecular pathways by which GTCs modulate prostate carcinogenesis is essential to apply the utilization of green tea for the chemoprevention of prostate cancer in clinical settings. The objective of this article is to review and summarize the most current literature focusing on the major mechanisms of GTC chemopreventative action on prostate cancer from laboratory, in vitro, and in vivo studies, and clinical chemoprevention trials.
authors.affiliation: Department of Cancer Epidemiology, Division of Population Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA. shahnjayla.connors@moffitt.org
authors.forename: Shahnjayla K
authors.initials: SK
authors.lastname: Connors
authors.forename: Ganna
authors.initials: G
authors.lastname: Chornokur
authors.forename: Nagi B
authors.initials: NB
authors.lastname: Kumar
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D061988:Proteasome Inhibitors; D013662:Tea / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D016328:NF-kappa B; D061988:Proteasome Inhibitors; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate
references.citation: Cancer Res. 1996 Oct 15;56(20):4644-8
references.pmid: 8840978
references.citation: Urol Oncol. 2005 Mar-Apr;23(2):108-13
references.pmid: 15869995
references.citation: J Nat Prod. 2004 Dec;67(12):2063-9
references.pmid: 15620252
references.citation: Cancer. 2003 Mar 15;97(6):1442-6
references.pmid: 12627508
references.citation: Int J Oncol. 1996 Feb;8(2):221-38
references.pmid: 21544351
references.citation: Clin Cancer Res. 2003 Aug 15;9(9):3312-9
references.pmid: 12960117
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5501-7
references.pmid: 15328189
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3850-5
references.pmid: 10725400
references.citation: Endocr Relat Cancer. 2002 Mar;9(1):61-73
references.pmid: 11914183
references.citation: J Nutr. 2003 Feb;133(2):516-21
references.pmid: 12566493
references.citation: Cancer Res. 2000 Mar 15;60(6):1541-5
references.pmid: 10749120
references.citation: Prostate. 2007 Oct 1;67(14):1576-89
references.pmid: 17705241
references.citation: J Biol Chem. 2001 Apr 20;276(16):13322-30
references.pmid: 11278274
references.citation: Cancer Res. 2006 Jan 15;66(2):1234-40
references.pmid: 16424063
references.citation: Lancet Oncol. 2001 May;2(5):278-89
references.pmid: 11905783
references.citation: J Exp Med. 1997 Dec 15;186(12):2075-80
references.pmid: 9396779
references.citation: Cancer Res. 1999 May 1;59(9):2115-20
references.pmid: 10232597
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):341-5
references.pmid: 19124518
references.citation: Nutr Cancer. 1994;22(1):1-10
references.pmid: 11304906
references.citation: Biochim Biophys Acta. 2002 Mar 14;1602(1):73-87
references.pmid: 11960696
references.citation: J Agric Food Chem. 2004 Feb 11;52(3):462-6
references.pmid: 14759133
references.citation: J Nutr. 2003 Jul;133(7 Suppl):2417S-2424S
references.pmid: 12840218
references.citation: Cancer Lett. 2009 Mar 8;275(1):86-92
references.pmid: 18977589
references.citation: J Int Med Res. 2003 Mar-Apr;31(2):88-101
references.pmid: 12760312
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Cancer Detect Prev. 2000;24(2):107-18
references.pmid: 10917130
references.citation: Carcinogenesis. 2006 Jul;27(7):1310-5
references.pmid: 16311246
references.citation: Expert Opin Investig Drugs. 2004 Dec;13(12):1541-54
references.pmid: 15566312
references.citation: Mol Endocrinol. 1992 May;6(5):753-62
references.pmid: 1376410
references.citation: Arch Biochem Biophys. 2000 Apr 15;376(2):338-46
references.pmid: 10775421
references.citation: Antioxid Redox Signal. 2008 Mar;10(3):475-510
references.pmid: 18154485
references.citation: Phytomedicine. 2010 Jan;17(1):3-13
references.pmid: 19959000
references.citation: Molecules. 2007 May 03;12(5):946-57
references.pmid: 17873830
references.citation: Urology. 2001 Apr;57(4 Suppl 1):46-51
references.pmid: 11295594
references.citation: Int J Cancer. 2003 Oct 10;106(6):856-62
references.pmid: 12918062
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2473-6
references.pmid: 17164372
references.citation: Cancer Lett. 2002 Aug 8;182(1):43-51
references.pmid: 12175522
references.citation: Pharmacol Res. 2011 Aug;64(2):87-99
references.pmid: 21371557
references.citation: Antimicrob Agents Chemother. 1995 Nov;39(11):2375-7
references.pmid: 8585711
references.citation: Toxicol Appl Pharmacol. 2000 Apr 1;164(1):82-90
references.pmid: 10739747
references.citation: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10350-5
references.pmid: 11504910
references.citation: J Agric Food Chem. 2007 Jun 27;55(13):5030-7
references.pmid: 17539658
references.citation: Int J Cancer. 2004 Dec 10;112(5):823-9
references.pmid: 15386368
references.citation: Curr Opin Investig Drugs. 2001 May;2(5):684-92
references.pmid: 11569948
references.citation: J Mol Biol. 1999 Apr 16;287(5):821-8
references.pmid: 10222191
references.citation: Science. 1995 Aug 4;269(5224):682-5
references.pmid: 7624798
references.citation: Nat Rev Cancer. 2006 Jun;6(6):449-58
references.pmid: 16723991
references.citation: J Cell Biochem Suppl. 1996;26:236-57
references.pmid: 9154181
references.citation: Pharmacol Res. 2011 Aug;64(2):123-35
references.pmid: 21419224
references.citation: Int J Cancer. 2005 Feb 10;113(4):660-9
references.pmid: 15455372
references.citation: J Clin Oncol. 2003 Jan 15;21(2):383-91
references.pmid: 12525533
references.citation: Annu Rev Cell Biol. 1993;9:541-73
references.pmid: 8280471
references.citation: Mol Carcinog. 2006 Jun;45(6):431-5
references.pmid: 16652355
references.citation: J Cell Biochem. 2004 Feb 1;91(2):232-42
references.pmid: 14743383
references.citation: Prostate. 2004 Apr 1;59(1):33-42
references.pmid: 14991864
references.citation: Anticancer Agents Med Chem. 2006 Sep;6(5):389-406
references.pmid: 17017850
references.citation: BJU Int. 2000 Feb;85(3):276-80
references.pmid: 10671881
references.citation: Eur Urol. 2008 Aug;54(2):472-3
references.pmid: 18406041
references.citation: J Nutr. 2002 Aug;132(8):2307-11
references.pmid: 12163680
references.citation: Annu Rev Pharmacol Toxicol. 1999;39:19-52
references.pmid: 10331075
references.citation: Mol Oncol. 2007 Sep;1(2):196-204
references.pmid: 18521193
references.citation: J Exp Med. 1998 Sep 7;188(5):997-1001
references.pmid: 9730902
references.citation: Clin Cancer Res. 2007 Mar 1;13(5):1611-9
references.pmid: 17332308
references.citation: Cell Tissue Res. 2003 Oct;314(1):61-8
references.pmid: 12915980
references.citation: Biochem Biophys Res Commun. 2005 Aug 26;334(2):543-8
references.pmid: 16005427
references.citation: J Trace Elem Med Biol. 2007;21(2):125-31
references.pmid: 17499153
references.citation: Evid Based Complement Alternat Med. 2006 Jun;3(2):237-47
references.pmid: 16786054
references.citation: Am J Pathol. 2009 Aug;175(2):489-99
references.pmid: 19628766
references.citation: Proc Soc Exp Biol Med. 1996 Nov;213(2):138-49
references.pmid: 8931660
references.citation: Nutr Cancer. 2009;61(6):836-41
references.pmid: 20155624
references.citation: Arch Biochem Biophys. 2003 Feb 1;410(1):177-85
references.pmid: 12559991
references.citation: Nutr Cancer. 2003;47(1):13-23
references.pmid: 14769533
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Jan;10(1):53-8
references.pmid: 11205489
references.citation: Endocrinology. 2000 Mar;141(3):980-7
references.pmid: 10698173
references.citation: Inflammopharmacology. 2008 Oct;16(5):208-12
references.pmid: 18815743
references.citation: Vitam Horm. 2001;62:1-94
references.pmid: 11345896
references.citation: Clin Cancer Res. 2002 Jul;8(7):2024-34
references.pmid: 12114400
references.citation: Biochem Pharmacol. 1999 Sep 15;58(6):911-5
references.pmid: 10509743
references.citation: Drugs Aging. 1997 Sep;11(3):229-44
references.pmid: 9303281
references.citation: Aliment Pharmacol Ther. 2004 Mar 1;19(5):497-510
references.pmid: 14987318
references.citation: J Natl Cancer Inst. 1997 Dec 17;89(24):1881-6
references.pmid: 9414176
references.citation: Clin Cancer Res. 2005 Jan 1;11(1):147-53
references.pmid: 15671539
references.citation: Curr Pharm Biotechnol. 2012 Jan;13(1):191-9
references.pmid: 21466438
references.citation: Clin Cancer Res. 2005 Jun 15;11(12):4627-33
references.pmid: 15958649
references.citation: J Nutr Biochem. 2011 May;22(5):502-10
references.pmid: 20801632
references.citation: Int J Cancer. 2004 Dec 10;112(5):787-92
references.pmid: 15386386
references.citation: J Cell Biochem Suppl. 1996;25:1-14
references.pmid: 9027592
references.citation: Trends Cell Biol. 2009 Mar;19(3):89-98
references.pmid: 19168356
references.citation: J Urol. 1994 May;151(5):1283-90
references.pmid: 7512659
references.citation: Nutr Cancer. 2009;61(6):827-35
references.pmid: 20155623
references.citation: Int J Urol. 2007 Jun;14(6):545-51
references.pmid: 17593102
references.citation: J Biol Chem. 1999 Mar 19;274(12):7724-31
references.pmid: 10075662
references.citation: Life Sci. 2007 Jul 26;81(7):519-33
references.pmid: 17655876
references.citation: Int J Cancer. 2004 Jan 1;108(1):130-5
references.pmid: 14618627
references.citation: Genes Dev. 1995 Nov 15;9(22):2723-35
references.pmid: 7590248
references.citation: Urology. 1999 Sep;54(3):523-7
references.pmid: 10475365
references.citation: Oncogene. 2008 Mar 27;27(14):2055-63
references.pmid: 17998943
references.citation: Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1025-32
references.pmid: 12376503
references.citation: Arch Androl. 2004 Jan-Feb;50(1):27-32
references.pmid: 14660168
references.citation: Cancer Chemother Pharmacol. 1999;43 Suppl:S42-51
references.pmid: 10357558
references.citation: Cancer Res. 2006 Mar 1;66(5):2500-5
references.pmid: 16510563
references.citation: Nat Rev Drug Discov. 2009 Jan;8(1):33-40
references.pmid: 19116625
references.citation: Cancer Lett. 1995 Sep 25;96(2):239-43
references.pmid: 7585463
references.citation: Evid Based Complement Alternat Med. 2007 Mar;4(1):17-22
references.pmid: 17342237
references.citation: Pol J Vet Sci. 2007;10(1):57-60
references.pmid: 17388027
references.citation: Acta Pharmacol Sin. 2010 Sep;31(9):1223-40
references.pmid: 20729872
references.citation: Life Sci. 2006 Nov 17;79(25):2329-36
references.pmid: 16945390
references.citation: Carcinogenesis. 2006 Apr;27(4):833-9
references.pmid: 16387739
references.citation: J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):471-83
references.pmid: 19023648
references.citation: Life Sci. 2001 Jan 26;68(10):1207-14
references.pmid: 11228105
references.citation: J Urol. 2006 Mar;175(3 Pt 1):820-34
references.pmid: 16469560
references.citation: Ann N Y Acad Sci. 1999 Jun 30;878:271-89
references.pmid: 10415736
references.citation: Cancer Treat Rev. 2000 Jun;26(3):191-204
references.pmid: 10814561
references.citation: Clin Cancer Res. 2009 Mar 15;15(6):1947-53
references.pmid: 19276266
references.citation: Pathol Oncol Res. 2001;7(1):14-23
references.pmid: 11349215
references.citation: Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):393-9
references.pmid: 7655336
references.citation: Mol Biosyst. 2010 Oct;6(10):1911-6
references.pmid: 20577699
references.citation: Pharm Res. 2008 Sep;25(9):2135-42
references.pmid: 18317887
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1662-6
references.pmid: 17684143
references.citation: Nutr Cancer. 1999;35(1):80-6
references.pmid: 10624710
references.citation: Mutat Res. 1999 Jul 16;428(1-2):339-44
references.pmid: 10518005
references.citation: BJU Int. 2007 Apr;99(4):908-15
references.pmid: 17378849
references.citation: Carcinogenesis. 2006 May;27(5):1047-53
references.pmid: 16314398
references.citation: In Vivo. 2005 Jan-Feb;19(1):179-83
references.pmid: 15796171
references.citation: Eur J Cancer Prev. 2003 Oct;12(5):383-90
references.pmid: 14512803
references.citation: Mutat Res. 2003 Feb-Mar;523-524:201-8
references.pmid: 12628518
references.citation: Eur J Biochem. 1994 Feb 15;220(1):45-53
references.pmid: 7509746
references.citation: J Natl Cancer Inst. 1997 Sep 3;89(17):1260-70
references.pmid: 9293916
references.citation: Toxicol Appl Pharmacol. 2007 Nov 1;224(3):265-73
references.pmid: 17234229
references.citation: Prostate. 2009 Feb 1;69(2):219-24
references.pmid: 18942120
references.citation: Am J Clin Nutr. 2000 Jun;71(6 Suppl):1698S-702S; discussion 1703S-4S
references.pmid: 10837321
references.citation: Neoplasia. 2000 Jul-Aug;2(4):291-9
references.pmid: 11005563
references.citation: Prostate. 2002 Aug 1;52(3):183-200
references.pmid: 12111695
references.citation: J Nutr. 2004 Dec;134(12 Suppl):3507S-3512S
references.pmid: 15570061
references.citation: Front Biosci (Elite Ed). 2009 Jun 01;1:13-25
references.pmid: 19482620
references.citation: N Engl J Med. 2004 Oct 7;351(15):1488-90
references.pmid: 15470210
references.citation: Cancer Prev Res (Phila). 2009 Jul;2(7):673-82
references.pmid: 19542190
references.citation: Nutr Rev. 2004 May;62(5):204-11
references.pmid: 15212320
references.citation: Cancer Res. 2003 Nov 15;63(22):7563-70
references.pmid: 14633667
references.citation: Biochem Biophys Res Commun. 1995 Sep 25;214(3):833-8
references.pmid: 7575552
references.citation: Oncogene. 2006 Oct 30;25(51):6800-16
references.pmid: 17072329
references.citation: Cancer Res. 2000 Jan 1;60(1):28-34
references.pmid: 10646846
references.citation: Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):83-9
references.pmid: 9950244
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):598-605
references.pmid: 17372258
references.citation: Cancer Metastasis Rev. 2001;20(3-4):287-96
references.pmid: 12085967
references.citation: Cancer Res. 2004 Dec 1;64(23):8715-22
references.pmid: 15574782
references.citation: Oncogene. 2003 Jul 31;22(31):4851-9
references.pmid: 12894226
references.citation: Crit Rev Food Sci Nutr. 1997 Dec;37(8):693-704
references.pmid: 9447270
references.citation: J Cancer Res Clin Oncol. 1999 Nov;125(11):589-97
references.pmid: 10541965
references.citation: N Engl J Med. 2008 May 8;358(19):2039-49
references.pmid: 18463380
references.citation: J Clin Oncol. 2001 Mar 15;19(6):1830-8
references.pmid: 11251015
references.citation: Cancer Res. 1999 May 1;59(9):2203-9
references.pmid: 10232609
references.citation: Nutrition. 1999 Nov-Dec;15(11-12):946-9
references.pmid: 10575676
references.citation: Cell. 2000 Jan 7;100(1):57-70
references.pmid: 10647931
references.citation: Semin Oncol. 2010 Jun;37(3):258-81
references.pmid: 20709209
references.citation: Carcinogenesis. 2004 Nov;25(11):2217-24
references.pmid: 15358631
references.citation: Oncogene. 2004 Apr 1;23(14):2507-22
references.pmid: 14676829
references.citation: Oncogene. 2000 Apr 6;19(15):1924-32
references.pmid: 10773882
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):351-4
references.pmid: 9568793
references.citation: Chem Biol Interact. 2008 Jan 10;171(1):89-95
references.pmid: 17931610
references.citation: Drug Resist Updat. 2007 Feb-Apr;10(1-2):13-29
references.pmid: 17303468
references.citation: Clin Chem. 2008 Dec;54(12):1951-60
references.pmid: 18927246
references.citation: J Biol Chem. 2003 Mar 28;278(13):11590-600
references.pmid: 12551933
references.citation: J Nutr. 2006 Jul;136(7):1839-43
references.pmid: 16772446
references.citation: Mol Pharmacol. 2002 Oct;62(4):765-71
references.pmid: 12237322
references.citation: Biochim Biophys Acta. 2000 Jul 31;1471(1):M43-56
references.pmid: 10967424
references.citation: Eur J Cancer Prev. 2002 Apr;11(2):137-45
references.pmid: 11984131
references.citation: FASEB J. 2010 Oct;24(10):3882-94
references.pmid: 20522783
references.citation: Cancer. 1999 Jan 1;85(1):178-87
references.pmid: 9921991
references.citation: Cancer Res. 2008 Aug 15;68(16):6762-9
references.pmid: 18701501
references.citation: Mol Med. 2002 Jul;8(7):382-92
references.pmid: 12393936
references.citation: Biochem Pharmacol. 2010 Oct 15;80(8):1115-24
references.pmid: 20599789
references.citation: Br J Biomed Sci. 2004;61(2):99-102
references.pmid: 15250676
references.citation: IARC Sci Publ. 1996;(139):13-22
references.pmid: 8923016
references.citation: Mod Pathol. 2004 Mar;17(3):360-79
references.pmid: 14739906
references.citation: Crit Rev Food Sci Nutr. 2003;43(1):89-143
references.pmid: 12587987
references.citation: Biofactors. 2007;29(1):19-35
references.pmid: 17611291
references.citation: Nature. 1995 Jul 6;376(6535):37-43
references.pmid: 7596430
references.citation: J Natl Cancer Inst. 2000 Sep 20;92(18):1472-89
references.pmid: 10995803
references.citation: Biochem Biophys Res Commun. 1996 Oct 14;227(2):564-9
references.pmid: 8878553
references.citation: Cancer Lett. 1998 Aug 14;130(1-2):1-7
references.pmid: 9751250
references.citation: Nutr Cancer. 1998;31(3):151-9
references.pmid: 9795966
references.citation: Int J Vitam Nutr Res. 2004 Jul;74(4):269-78
references.pmid: 15580809
references.citation: N Engl J Med. 1991 Jan 24;324(4):236-45
references.pmid: 1985245
references.citation: Drug Metab Dispos. 1997 Sep;25(9):1045-50
references.pmid: 9311619
references.citation: Mol Carcinog. 2010 Aug;49(8):739-49
references.pmid: 20623641
references.citation: Science. 1996 Dec 6;274(5293):1672-7
references.pmid: 8939849
references.citation: Clin Exp Metastasis. 1998 Aug;16(6):513-28
references.pmid: 9872599
references.citation: Int J Cancer. 2010 Jun 1;126(11):2520-33
references.pmid: 19856314
references.citation: Cancer Sci. 2010 Mar;101(3):707-12
references.pmid: 20002680
references.citation: Biochem Pharmacol. 2002 Mar 15;63(6):1165-76
references.pmid: 11931850
references.citation: Toxicol Pathol. 2003 Jan-Feb;31(1):39-51
references.pmid: 12597448