title: Field application of SPME as a novel tool for occupational exposure assessment with inhalational anesthetics.
abstract: Occupational exposure to inhalational anesthetics occurs routinely in operating rooms. It could induce serious health hazards and diseases. This exposure assessment is a crucial step in determining risks. In this study, a pen-shaped holder for solid-phase microextraction (SPME) sampler was successfully applied as a time-weighted average sampling tool for workshift exposure assessment of operation room staff to halothane. It proved to be very convenient for use in occupational environments such as operation rooms. Samples were analyzed by a gas chromatography-mass spectrometry. The validity of the SPME method was checked in real-world conditions with Occupational Safety and Health Administration (OSHA) 103 standard method for the determination of inhalational anesthetics. A good agreement between OSHA 103 and SPME methods was obtained and results demonstrated no statistically significant differences in anesthetic concentrations determined by the two analytical methods (p ≥ 0.05). It is concluded that SPME in retracted mode could successfully be applied in occupational exposure assessment purposes.
authors.affiliation: Department of Occupational Health, Research Centre for Health Sciences, School of Public Health, Hamedan University of Medical Science, Hamadan, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Zare Sakhvidi
authors.forename: AbdulRahman
authors.initials: A
authors.lastname: Bahrami
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghiasvand
authors.forename: Hossein
authors.initials: H
authors.lastname: Mahjub
authors.forename: Ludovic
authors.initials: L
authors.lastname: Tuduri
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis / Q000706:statistics & numerical data; D018685:Anesthetics, Inhalation / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D006221:Halothane / Q000032:analysis*; D016273:Occupational Exposure / Q000032:analysis / Q000706:statistics & numerical data; D009873:Operating Rooms / Q000706:statistics & numerical data; D052617:Solid Phase Microextraction / Q000379:methods
chemical_list: D000395:Air Pollutants, Occupational; D018685:Anesthetics, Inhalation; D006221:Halothane
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