title: Packaging of fat: an evolving model of lipid droplet assembly and expansion.
abstract: Lipid droplets (LDs) are organelles found in most types of cells in the tissues of vertebrates, invertebrates, and plants, as well as in bacteria and yeast. They differ from other organelles in binding a unique complement of proteins and lacking an aqueous core but share aspects of protein trafficking with secretory membrane compartments. In this minireview, we focus on recent evidence supporting an endoplasmic reticulum origin for LD formation and discuss recent findings regarding LD maturation and fusion.
authors.affiliation: Rutgers Center for Lipid Research and Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA. brasaemle@aesop.rutgers.edu
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Brasaemle
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Wolins
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D010944:Plants / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism*
references.citation: J Cell Sci. 2009 Jun 1;122(Pt 11):1834-41
references.pmid: 19461073
references.citation: Traffic. 2008 Mar;9(3):338-52
references.pmid: 18088320
references.citation: J Lipid Res. 2007 Dec;48(12):2547-59
references.pmid: 17878492
references.citation: J Biol Chem. 2003 Sep 26;278(39):37713-21
references.pmid: 12840023
references.citation: J Biol Chem. 2004 Oct 1;279(40):42062-71
references.pmid: 15292255
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20890-5
references.pmid: 18093937
references.citation: J Biol Chem. 2004 Jul 16;279(29):30490-7
references.pmid: 15136565
references.citation: J Biol Chem. 2007 Feb 23;282(8):5726-35
references.pmid: 17189257
references.citation: J Biol Chem. 2009 Dec 11;284(50):34538-44
references.pmid: 19850935
references.citation: J Lipid Res. 2011 Dec;52(12):2136-2147
references.pmid: 21957196
references.citation: J Biol Chem. 2011 May 6;286(18):15707-15
references.pmid: 21393244
references.citation: J Biol Chem. 2002 Mar 8;277(10):8635-47
references.pmid: 11739396
references.citation: Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1395-413
references.pmid: 19843876
references.citation: J Biol Chem. 2008 Oct 17;283(42):28005-9
references.pmid: 18611863
references.citation: Biochim Biophys Acta. 2009 Jun;1791(6):501-6
references.pmid: 19038363
references.citation: J Cell Biol. 1970 Aug;46(2):326-41
references.pmid: 5449178
references.citation: J Biol Chem. 2011 Jun 17;286(24):21330-9
references.pmid: 21498505
references.citation: J Biol Chem. 2009 Nov 13;284(46):32116-25
references.pmid: 19717842
references.citation: J Biol Chem. 2010 May 21;285(21):15663-7
references.pmid: 20231294
references.citation: Biochim Biophys Acta. 2007 Jul;1771(7):830-8
references.pmid: 17493869
references.citation: J Biol Chem. 2004 Jul 2;279(27):28817-25
references.pmid: 15069071
references.citation: J Lipid Res. 2007 Apr;48(4):837-47
references.pmid: 17210984
references.citation: J Lipid Res. 2010 Feb;51(2):262-73
references.pmid: 19965608
references.citation: Nat Genet. 2001 Aug;28(4):365-70
references.pmid: 11479539
references.citation: Biochim Biophys Acta. 1997 Sep 4;1348(1-2):35-44
references.pmid: 9370314
references.citation: Biochim Biophys Acta. 2010 Mar;1801(3):246-51
references.pmid: 19818872
references.citation: J Biol Chem. 2011 May 13;286(19):17338-50
references.pmid: 21454708
references.citation: FEBS Lett. 2010 Jan 4;584(1):86-92
references.pmid: 19896941
references.citation: Trends Endocrinol Metab. 2011 Jun;22(6):204-10
references.pmid: 21497513
references.citation: J Biol Chem. 1994 Nov 4;269(44):27494-502
references.pmid: 7961664
references.citation: J Biol Chem. 2001 Nov 9;276(45):42205-12
references.pmid: 11546763
references.citation: J Biol Chem. 2009 Feb 20;284(8):5352-61
references.pmid: 19049983
references.citation: Nature. 2008 May 29;453(7195):657-61
references.pmid: 18408709
references.citation: J Biol Chem. 2009 Nov 6;284(45):30941-8
references.pmid: 19748893
references.citation: J Clin Invest. 2008 Aug;118(8):2808-21
references.pmid: 18654663
references.citation: J Cell Biol. 2011 Mar 21;192(6):1043-55
references.pmid: 21422231
references.citation: Nat Cell Biol. 2007 Nov;9(11):1286-93
references.pmid: 17922004
references.citation: Plant Physiol. 1996 Apr;110(4):1055-61
references.pmid: 8934621
references.citation: Cell Metab. 2008 Apr;7(4):302-11
references.pmid: 18396136
references.citation: Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E1-9
references.pmid: 19141679
references.citation: Diabetes. 2004 May;53(5):1261-70
references.pmid: 15111495
references.citation: J Cell Biol. 2008 Feb 11;180(3):473-82
references.pmid: 18250201
references.citation: PLoS Genet. 2011 Apr;7(4):e1001364
references.pmid: 21533227
references.citation: J Lipid Res. 1995 Jun;36(6):1211-26
references.pmid: 7665999
references.citation: J Cell Sci. 2011 Jul 15;124(Pt 14):2424-37
references.pmid: 21693588
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):94-9
references.pmid: 18160536
references.citation: J Biol Chem. 2006 Dec 29;281(52):40236-41
references.pmid: 17074755
references.citation: J Biol Chem. 2007 Nov 23;282(47):34213-8
references.pmid: 17884815
references.citation: Plant Cell. 1997 Aug;9(8):1481-93
references.pmid: 9286116
references.citation: J Cell Biol. 2003 Jun 23;161(6):1093-103
references.pmid: 12810697
references.citation: Biochem J. 2009 Oct 23;424(1):61-7
references.pmid: 19708857
references.citation: J Lipid Res. 2007 May;48(5):1078-89
references.pmid: 17308334
references.citation: Biochemistry. 2010 Dec 21;49(50):10747-55
references.pmid: 21062080
references.citation: J Biol Chem. 2011 Dec 9;286(49):42188-42199
references.pmid: 22002063
references.citation: J Biol Chem. 2011 Aug 12;286(32):28235-46
references.pmid: 21680734
references.citation: Mol Cell Biochem. 2009 Jun;326(1-2):15-21
references.pmid: 19116774
references.citation: FEBS Lett. 2006 Oct 9;580(23):5484-91
references.pmid: 16962104
references.citation: Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1195-209
references.pmid: 19336658
references.citation: J Biol Chem. 2006 Dec 29;281(52):40273-82
references.pmid: 17035227
references.citation: Cell Metab. 2006 May;3(5):309-19
references.pmid: 16679289
references.citation: PLoS Biol. 2008 Nov 25;6(11):e292
references.pmid: 19067489
references.citation: J Biol Chem. 2002 Nov 15;277(46):44507-12
references.pmid: 12221100
references.citation: Cell Metab. 2011 Oct 5;14(4):504-15
references.pmid: 21982710
references.citation: J Lipid Res. 2007 Jan;48(1):9-18
references.pmid: 17057226
references.citation: J Biol Chem. 1980 Oct 25;255(20):9599-607
references.pmid: 7430088
references.citation: J Lipid Res. 2011 Dec;52(12):2159-2168
references.pmid: 21885430
references.citation: Cell. 2005 Jul 15;122(1):85-95
references.pmid: 16009135
references.citation: J Biol Chem. 2010 Apr 16;285(16):12289-98
references.pmid: 20164531
references.citation: Hum Mol Genet. 2011 Aug 1;20(15):3022-30
references.pmid: 21551454
references.citation: J Biol Chem. 2005 May 13;280(19):19146-55
references.pmid: 15731108
references.citation: J Lipid Res. 2008 Nov;49(11):2283-301
references.pmid: 18757836
references.citation: PLoS One. 2008 Aug 06;3(8):e2890
references.pmid: 18682832
references.citation: J Biol Chem. 2009 Jan 30;284(5):2593-7
references.pmid: 18812320