title: SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.
abstract: In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
authors.affiliation: Research Institute, National Cancer Center, 809 Madu 1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do 411-764, South Korea. yoons@ncc.re.kr
authors.forename: Sungpil
authors.initials: S
authors.lastname: Yoon
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Yi
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Ju-Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Won Sang
authors.initials: WS
authors.lastname: Park
authors.forename: Suk Woo
authors.initials: SW
authors.lastname: Nam
mesh_terms: D020869:Gene Expression Profiling; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D009928:Organ Specificity; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D050826:Suppressor of Cytokine Signaling Proteins / Q000096:biosynthesis* / Q000235:genetics; D013964:Thyroid Neoplasms / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; C408990:SOCS5 protein, human; C473085:SOCS6 protein, human; D050826:Suppressor of Cytokine Signaling Proteins
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