title: Robotic stereotactic body radiotherapy in the treatment of sinonasal mucosal melanoma: report of four cases.
abstract: BACKGROUND
  Sinonasal mucosal melanoma (SNMM) is a rare entity originating from melanocytes of the sinonasal mucosa. Postoperative radiotherapy is recommended in all cases to increase local control. However, external radiotherapy is rarely used as a definitive treatment modality. In this report, we present 4 cases of SNMM treated with CyberKnife (Accuray, Sunnyvale, CA).
  
  
  METHODS
  All patients were immobilized with a thermoplastic mask. A planning CT scan with 1-mm thickness was obtained, and these images were fused with MRI for the contouring procedure. Multiplan (Accuray) inverse planning software was used for treatment planning. Robotic stereotactic body radiotherapy (SBRT) was delivered with CyberKnife.
  
  
  RESULTS
  Median follow-up was 26 months. Three patients had complete response to CyberKnife, and 1 patient had partial response.
  
  
  CONCLUSIONS
  Robotic SBRT seems to be an appealing treatment option for local control. Effective systemic treatment is required to prevent distant metastases.
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Radiation Oncology, Ankara, Turkey. gozyigit@hacettepe.edu.tr
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozyigit
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cengiz
authors.forename: Gozde
authors.initials: G
authors.lastname: Yazici
authors.forename: Ferah
authors.initials: F
authors.lastname: Yildiz
authors.forename: Duygu
authors.initials: D
authors.lastname: Sezen
authors.forename: Demet
authors.initials: D
authors.lastname: Yildiz
authors.forename: Murat
authors.initials: M
authors.lastname: Gurkaynak
authors.forename: Faruk
authors.initials: F
authors.lastname: Zorlu
authors.forename: Fadil
authors.initials: F
authors.lastname: Akyol
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008545:Melanoma / Q000601:surgery*; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D012371:Robotics / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome