title: Serum antibodies and anthropometric data at diagnosis in pediatric Crohn's disease.
abstract: BACKGROUND
  Serum antibodies, including ASCA, anti-OmpC, and ANCA, correlate with disease location and predict disease phenotype in inflammatory bowel disease.
  
  
  OBJECTIVE
  The objective of this study was to determine relationships between serum antibody status and anthropometric data for children with newly diagnosed Crohn's disease.
  
  
  METHODS
  A retrospective review was conducted on children diagnosed with Crohn's disease at our institution from 2003 to 2008. Patients who had ASCA IgA, ASCA IgG, anti-OmpC, and pANCA antibodies, and anthropometric data measured before diagnosis and therapy were included. Z-scores for height and weight were compared among groups according to the presence of specific antibodies. Spearman's rank correlation was used to assess association between antibodies and growth data.
  
  
  RESULTS
  One hundred and two patients, mean age 11.9 years, met the inclusion criteria. Patients with the presence of any of the four antibodies had lower mean height and weight z-scores than patients without any antibodies present. When individual antibodies were studied, patients with positive ASCA titers had lower mean weight and height z-scores than patients without any antibodies present. Spearman's rank correlation coefficient demonstrated a significant association between increasing ASCA titers and lower weight z-scores, but not lower height z-scores.
  
  
  CONCLUSIONS
  Pediatric patients with newly diagnosed Crohn's disease and the presence of ASCA antibodies have lower mean height and weight z-scores. This study provides evidence that specific subsets of children with Crohn's disease may be at greater risk of growth impairment.
authors.affiliation: Division of Pediatric Gastroenterology/Hepatology/Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive/ROC 4210, Indianapolis, IN 46202-5225, USA.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Trauernicht
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Steiner
mesh_terms: D000906:Antibodies / Q000097:blood*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000907:Antibodies, Bacterial / Q000097:blood; D000908:Antibodies, Fungal / Q000097:blood; D001827:Body Height; D001835:Body Weight; D002648:Child; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D018272:Porins / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000276:immunology
chemical_list: D000906:Antibodies; D019268:Antibodies, Antineutrophil Cytoplasmic; D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; C113724:OmpC protein; D018272:Porins
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