title: Psoriasiform disorders with joint symptoms.
abstract: We present a 49-year-old man seen at the dermatology outpatient department with a 3-year history of painful swollen digits of hands and feet. On enquiry he reported dysuria. On examination we saw extensive swelling of the digits, keratosis of the nails, and some psoriasiform skin lesions on the soles of the feet. The differential diagnosis included acrodermatitis continua suppurativa, reactive arthritis and psoriatic arthritis. Radiographic imaging revealed the presence of arthritis. Testing proved negative for rheumatoid factor and positive for HLA-B27 making spondyloarthropathy the most likely diagnosis, either in the form of reactive arthritis or psoriatic arthritis. The patient was treated with combination therapy of doxycycline, methotrexate and folic acid. Because of insufficient response to therapy, the methotrexate dose was raised and eventually etanercept was added. During the last visit to the outpatient clinic, the patient still showed insufficient response to therapy.
authors.affiliation: Maastricht Universitair Medisch Centrum, Maastricht, the Netherlands. k.mosterd@mumc.nl
authors.forename: Klara
authors.initials: K
authors.lastname: Mosterd
authors.forename: Theodoor H
authors.initials: TH
authors.lastname: Kapinga
authors.forename: Herm
authors.initials: H
authors.lastname: Martens
authors.forename: Paul L H
authors.initials: PL
authors.lastname: van Mierlo
authors.forename: Thea H M
authors.initials: TH
authors.lastname: Schoonbrood
authors.forename: Pamela
authors.initials: P
authors.lastname: Poblete-Gutiérrez
mesh_terms: D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy; D016918:Arthritis, Reactive / Q000175:diagnosis / Q000188:drug therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004318:Doxycycline / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D025242:Spondylarthropathies / Q000175:diagnosis* / Q000188:drug therapy; D017211:Treatment Failure
chemical_list: D003879:Dermatologic Agents; D005492:Folic Acid; D004318:Doxycycline; D008727:Methotrexate