title: Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis.
abstract: BACKGROUND
  Chemerin has been implicated to be correlated with inflammation.
  
  
  OBJECTIVE
  This study aims to determine the association of chemerin levels in serum and synovial fluid (SF) with the disease severity of patients with knee Osteoarthritis (OA).
  
  
  METHODS
  124 patients with knee OA and 76 healthy controls were enrolled in this study.
  
  
  RESULTS
  Chemerin levels in serum were significant higher with regard to paired SF. Chemerin levles in SF of knee OA patients were correlated with disease severity evaluated by KL grading criteria.
  
  
  CONCLUSIONS
  Chemerin levels may be involved in the pathophysiology of the development and progression of OA.
authors.affiliation: Department of Orthopaedic Surgery, The Second People's Hospital of Nanning, Guangxi, PR China. gxhuangke@126.com
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Hongsuo
authors.initials: H
authors.lastname: Liang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D018925:Chemokines / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D011859:Radiography; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry* / Q000378:metabolism
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human