title: Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase.
abstract: A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC(50) 91.13 μM) against PfENR.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Akhtar
authors.initials: A
authors.lastname: Muhammad
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Sufyan
authors.initials: S
authors.lastname: Awadelkarim
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.forename: Asaad
authors.initials: A
authors.lastname: Khalid
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Galal
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Iqbal Choudhary
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D047309:Flavones / Q000138:chemical synthesis* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D010936:Plant Extracts / Q000494:pharmacology*; D010944:Plants / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D047309:Flavones; D005419:Flavonoids; D010936:Plant Extracts; C574029:methylenebissantin; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)