title: Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007.
abstract: Since 2001, the World Health Organization classification for hematopoietic and lymphoid neoplasms has provided a framework for defining acute leukemia (AL) subtypes, although few population-based studies have assessed incidence patterns and patient survival accordingly. We assessed AL incidence rates (IRs), IR ratios (IRRs), and relative survival in the United States (2001-2007) in one of the first population-based, comprehensive assessments. Most subtypes of acute myeloid leukemia (AML) and acute lymphoblastic leukemia/lymphoma (ALL/L) predominated among males, from twice higher incidence of T-cell ALL/L among males than among females (IRR = 2.20) to nearly equal IRs of acute promyelocytic leukemia (APL; IRR = 1.08). Compared with non-Hispanic whites, Hispanics had significantly higher incidence of B-cell ALL/L (IRR = 1.64) and APL (IRR = 1.28); blacks had lower IRs of nearly all AL subtypes. All ALL/L but only some AML subtypes were associated with a bimodal age pattern. Among AML subtypes, survival was highest for APL and AML with inv(16). B-cell ALL/L had more favorable survival than T-cell ALL/L among the young; the converse occurred at older ages. Limitations of cancer registry data must be acknowledged, but the distinct AL incidence and survival patterns based on the World Health Organization classification support biologic diversity that should facilitate etiologic discovery, prognostication, and treatment advances.
authors.affiliation: Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA. doresg@mail.nih.gov
authors.forename: Graça M
authors.initials: GM
authors.lastname: Dores
authors.forename: Susan S
authors.initials: SS
authors.lastname: Devesa
authors.forename: Rochelle E
authors.initials: RE
authors.lastname: Curtis
authors.forename: Martha S
authors.initials: MS
authors.lastname: Linet
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000401:mortality*; D018426:SEER Program; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D055815:Young Adult
references.citation: Blood. 2010 Mar 25;115(12):2372-9
references.pmid: 20056794
references.citation: Blood. 2011 Aug 4;118(5):1248-54
references.pmid: 21653939
references.citation: Best Pract Res Clin Haematol. 2001 Mar;14(1):19-47
references.pmid: 11355922
references.citation: Blood. 2010 Jan 14;115(2):206-14
references.pmid: 19897583
references.citation: Leuk Res. 2010 Oct;34(10):1271-4
references.pmid: 20189245
references.citation: Leukemia. 2010 Apr;24(4):894-6
references.pmid: 20054350
references.citation: Blood. 2010 Mar 11;115(10):1985-92
references.pmid: 20040759
references.citation: Cancer Causes Control. 2009 Nov;20(9):1671-80
references.pmid: 19672681
references.citation: Blood. 2011 Dec 15;118(25):6521-8
references.pmid: 21931113
references.citation: Leuk Lymphoma. 2004 Jul;45(7):1365-8
references.pmid: 15359634
references.citation: Blood. 2006 Jan 1;107(1):265-76
references.pmid: 16150940
references.citation: Ann Hematol. 2004 Aug;83(8):513-21
references.pmid: 15173958
references.citation: Leukemia. 2010 Apr;24(4):903-7
references.pmid: 20164851
references.citation: Blood. 2009 Apr 16;113(16):3666-72
references.pmid: 19020306
references.citation: J Clin Oncol. 2006 Aug 20;24(24):3904-11
references.pmid: 16921041
references.citation: Hematology Am Soc Hematol Educ Program. 2010;2010:56-61
references.pmid: 21239771
references.citation: Blood. 2001 Jun 15;97(12):3727-32
references.pmid: 11389009
references.citation: Blood. 2009 Apr 30;113(18):4179-87
references.pmid: 19008455
references.citation: Curr Opin Pediatr. 2009 Feb;21(1):1-8
references.pmid: 19242236
references.citation: Cancer. 2009 Jul 1;115(13):2903-11
references.pmid: 19452536
references.citation: Blood. 2001 Sep 1;98(5):1312-20
references.pmid: 11520776
references.citation: Blood. 2011 Nov 10;118(19):5080-3
references.pmid: 21937689
references.citation: Blood. 2011 Jun 30;117(26):7102-11
references.pmid: 21551233
references.citation: Cancer Genet Cytogenet. 2001 Apr 15;126(2):155-61
references.pmid: 11376809
references.citation: Nat Genet. 2010 Apr;42(4):338-42
references.pmid: 20228800
references.citation: Cancer. 2008 Nov 1;113(9):2575-96
references.pmid: 18837040
references.citation: Haematologica. 2008 Apr;93(4):594-600
references.pmid: 18322250
references.citation: Eur J Cancer Prev. 2006 Aug;15(4):367-70
references.pmid: 16835508
references.citation: Blood. 2005 Dec 1;106(12):3760-7
references.pmid: 16105981
references.citation: Lancet. 2008 Mar 22;371(9617):1030-43
references.pmid: 18358930
references.citation: Leukemia. 2011 Jul;25(7):1128-34
references.pmid: 21502956
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):611-5
references.pmid: 19208664
references.citation: Blood. 1998 Oct 1;92(7):2322-33
references.pmid: 9746770
references.citation: Eur J Haematol. 2009 Nov;83(5):391-405
references.pmid: 19563518
references.citation: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references.pmid: 20610543
references.citation: Blood. 2010 Nov 11;116(19):3724-34
references.pmid: 20664057
references.citation: Blood. 2010 Jul 22;116(3):354-65
references.pmid: 20385793
references.citation: Blood. 2000 Oct 1;96(7):2405-11
references.pmid: 11001891
references.citation: Cancer Causes Control. 2008 May;19(4):379-90
references.pmid: 18064533
references.citation: Br J Haematol. 2003 Aug;122(4):563-70
references.pmid: 12899711
references.citation: Blood. 2008 Jul 1;112(1):45-52
references.pmid: 18443215
references.citation: Eur J Cancer Prev. 2010 Jul;19(4):247-55
references.pmid: 20395866
references.citation: Blood. 2007 Oct 1;110(7):2309-15
references.pmid: 17496201
references.citation: Leuk Lymphoma. 2006 Nov;47(11):2365-70
references.pmid: 17107911
references.citation: Haematologica. 2005 Nov;90(11):1502-10
references.pmid: 16266897
references.citation: Leukemia. 2000 Apr;14(4):722-6
references.pmid: 10764161