title: Synthesis of a novel pentasaccharide core component from the lipooligosaccharide of Moraxella catarrhalis.
abstract: The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranosyl-6-O-[2-O-(α-D-glucopyranosyl)-β-D-glucopyranosyl]-α-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.
authors.affiliation: School of Medical Science, Griffith University Gold Coast Campus, Queensland 4222, Australia.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Pearson
authors.forename: Ian R
authors.initials: IR
authors.lastname: Peak
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Wilson
authors.forename: I Darren
authors.initials: ID
authors.lastname: Grice
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008070:Lipopolysaccharides / Q000737:chemistry*; D008969:Molecular Sequence Data; D001936:Moraxella catarrhalis; D009844:Oligosaccharides / Q000138:chemical synthesis*
chemical_list: C570780:(p-(trifluoroacetamido)phenyl)ethyl 3-O-glucopyranosyl-4-O-glucopyranosyl-6-O-(2-O-(glucopyranosyl)glucopyranosyl)glucopyranoside; D008070:Lipopolysaccharides; D009844:Oligosaccharides