title: Biological activities of Indian celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh.
abstract: In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH-H(2) O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abbaskhan
authors.forename: Muhammed Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Mohammed Nabeel
authors.initials: MN
authors.lastname: Ghayur
authors.forename: Zeba
authors.initials: Z
authors.lastname: Parween
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
authors.forename: Anwar-ul-Hassan
authors.initials: AU
authors.lastname: Gilani
authors.forename: Takuro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Kiran
authors.initials: K
authors.lastname: Iqbal
authors.forename: Yoshisuke
authors.initials: Y
authors.lastname: Tsuda
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004232:Diuretics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010276:Parasympatholytics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D052117:Benzodioxoles; D003374:Coumarins; D004232:Diuretics; D011564:Furocoumarins; D010276:Parasympatholytics; D010936:Plant Extracts; C583738:anthriscinol methyl ether; C015304:isopimpinellin; C516746:seselin