title: Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.
abstract: The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Nguyen Thi Kim
authors.initials: NT
authors.lastname: Thuy
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Ninh Khac
authors.initials: NK
authors.lastname: Ban
authors.forename: Dan Thuy
authors.initials: DT
authors.lastname: Hang
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Tuyen
authors.forename: Vivek Bhakta
authors.initials: VB
authors.lastname: Mathema
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Koh
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D027343:Rhizome / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: C570586:15-methoxylabda-8(17),13-dien-16,15-olide; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C570587:coronarin H; C570588:hedyforrestin C; D018664:Interleukin-12