title: Percutaneous cryoablation of pulmonary metastases from colorectal cancer.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of cryoablation for metastatic lung tumors from colorectal cancer.
  
  
  METHODS
  The procedures were performed on 24 patients (36-82 years of age, with a median age of 62; 17 male patients, 7 female patients) for 55 metastatic tumors in the lung, during 30 sessions. The procedural safety, local progression free interval, and overall survival were assessed by follow-up computed tomographic scanning performed every 3-4 months.
  
  
  RESULTS
  The major complications were pneumothorax, 19 sessions (63%), pleural effusion, 21 sessions (70%), transient and self-limiting hemoptysis, 13 sessions (43%) and tract seeding, 1 session (3%). The 1- and 3-year local progression free intervals were 90.8% and 59%, respectively. The 3-years local progression free intervals of tumors ≤15 mm in diameter was 79.8% and that of tumors >15 mm was 28.6% (p = 0.001; log-rank test). The 1- and 3-year overall survival rates were 91% and 59.6%, respectively.
  
  
  CONCLUSIONS
  The results indicated that percutaneous cryoablation is a feasible treatment option. The local progression free interval was satisfactory at least for tumors that were ≤15 mm in diameter.
authors.affiliation: Department of Surgery, School of Medicine, Keio University, Tokyo, Japan. yoshikaney@2004.jukuin.keio.ac.jp
authors.forename: Yoshikane
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kawamura
authors.forename: Seishi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Hideki
authors.initials: H
authors.lastname: Yashiro
authors.forename: Norimasa
authors.initials: N
authors.lastname: Tsukada
authors.forename: Masanori
authors.initials: M
authors.lastname: Inoue
authors.forename: Keisuke
authors.initials: K
authors.lastname: Asakura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nomori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000150:complications*; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome
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