title: Pleiotropic cellular, hemostatic, and biological actions of Ankaferd hemostat.
abstract: Sustaining hemostasis in clinical hemorrhages is a challenging task and requires extensive effort to stabilize medically hard-to-treat traumatic injuries. Several hemostatic agents are preferred to control external and internal bleedings, yet commercially available products are not sufficiently effective or fast-acting to achieve hemostasis in extreme cases. Ankaferd Blood Stopper (ABS) is a herbal extract traditionally used as a hemostatic agent. Recent studies have shown that ABS could be utilized successfully as a hemostatic agent for the management of clinical hemorrhages when conventional methods were ineffective. This review serves as a basis to provide recent findings on several applications of ABS, specifically preclinical, biological, and clinical studies both in vitro and in vivo. Another section focuses on the ultrastructural morphology and protein network formation of ABS in an effort to understand the hemostatic mechanisms of this unique agent at tissue level.
authors.affiliation: Department of Chemical and Environmental Engineering, Yale University, New Haven, CT 06511, USA.
authors.forename: Berat Z
authors.initials: BZ
authors.lastname: Haznedaroglu
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Beyazit
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Walker
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D002986:Clinical Trials as Topic; D019468:Disease Management; D004304:Dosage Forms; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001798:Blood Proteins; D004304:Dosage Forms; D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper