title: Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation: preliminary results of a Japanese series.
abstract: OBJECTIVE
  We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation.
  
  
  METHODS
  The subjects were ten patients who received lung grafts preserved with EP-TU solution at three of four designated lung transplant centers between 2000 and 2005. Three of the patients underwent single lung transplantation and seven underwent bilateral lung transplantation. Postoperative graft function was evaluated by primary graft dysfunction (PGD) grade (0-3), arterial oxygen tension/inspired oxygen fraction (PaO(2)/FiO(2)) ratio, and the previously reported chest roentgenogram score (CRS, 0-4) during the first 48 h after intensive care unit admission. Survival rates were also calculated.
  
  
  RESULTS
  The average graft ischemic times for the first and second grafts were 431 and 571 min, respectively. The average PGD grade ranged from 0.5 to 1.0 and the average PaO(2)/FiO(2) ratio ranged from 350 to 400 Torr during the 48 h. The average CRS was always under 1.0. Survival rates at 30 days and 5 years were 90 and 80%, respectively.
  
  
  CONCLUSIONS
  EP-TU solution promoted excellent postoperative lung graft function and enhanced recipient survival rates, despite a long average preservation time.
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan. yokada@idac.tohoku.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Okada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Toru
authors.initials: T
authors.lastname: Bando
authors.forename: Takahiro
authors.initials: T
authors.lastname: Oto
authors.forename: Tetsu
authors.initials: T
authors.lastname: Sado
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hoshikawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Noda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000328:Adult; D002021:Buffers; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D055031:Primary Graft Dysfunction / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002021:Buffers; D019188:Organ Preservation Solutions; D010710:Phosphates
references.citation: J Heart Lung Transplant. 2009 Oct;28(10):1031-49
references.pmid: 19782285
references.citation: Semin Thorac Cardiovasc Surg. 2004 Winter;16(4):300-8
references.pmid: 15635534
references.citation: Surg Today. 2009;39(7):641-5
references.pmid: 19562458
references.citation: Transplantation. 1997 Sep 27;64(6):801-6
references.pmid: 9326401
references.citation: Transplant Proc. 1987 Feb;19(1 Pt 2):1334-6
references.pmid: 3274329
references.citation: J Heart Lung Transplant. 1998 May;17(5):525-31
references.pmid: 9628573
references.citation: Tohoku J Exp Med. 1989 Nov;159(3):205-14
references.pmid: 2623663
references.citation: J Heart Lung Transplant. 2004 Sep;23(9):1087-92
references.pmid: 15454176
references.citation: Transplantation. 1990 Apr;49(4):690-4
references.pmid: 1691536
references.citation: J Heart Lung Transplant. 1992 Mar-Apr;11(2 Pt 1):377-92
references.pmid: 1576146
references.citation: Ann Thorac Cardiovasc Surg. 2006 Feb;12(1):10-4
references.pmid: 16572068
references.citation: Ann Thorac Surg. 2003 Mar;75(3):990-5
references.pmid: 12645729
references.citation: J Thorac Cardiovasc Surg. 1992 Feb;103(2):314-25
references.pmid: 1370970
references.citation: Gen Thorac Cardiovasc Surg. 2009 Dec;57(12):635-9
references.pmid: 20013097
references.citation: J Heart Lung Transplant. 2005 Oct;24(10):1454-9
references.pmid: 16210116