title: The relationship between glutathione peroxidase and bioimpedance parameters in nondiabetic hemodialysis patients.
abstract: There is growing evidence from experimental and clinical studies that oxidative stress is involved in the pathogenesis of malnutrition. This cross-sectional study aimed to investigate the relationship between glutathione peroxidase (GPx) levels as a marker of antioxidant status and the nutritional status assessed by bioimpedance analysis (BIA). Ninety-seven nondiabetic stable outpatient uremic adults undergoing chronic hemodialysis (HD) were recruited for this study. Impedance measurements were performed using a multifrequency bioelectrical impedance analyzer after dialysis. GPx levels correlated with intracellular water (ICW) (r = 0.341, P = 0.011), ICW/total body weight (r = 0.320, P = 0.017), lean body mass (r = 0.300, P = 0.026) and total body cell mass (r = 0.339, P = 0.011). When patients were divided into two groups according to mean GPx levels (83.9 U/gr hemoglobin), the patients with higher GPx (GPx > 83.9 U/gr hemoglobin) had higher albumin (P = 0.038), lean body mass (P = 0.026), ICW (P = 0.011), and total body cell mass (P = 0.011) compared with those with lower GPx (GPx ≤ 83.9 U/gr hemoglobin). Furthermore, in the patients with higher GPx, body fat; extracellular water/total body water; illness marker and body fat mass index were lower than other group. In conclusion, our results reveal correlation indicating a relationship between antioxidant status (as measured by GPx) and nutritional status as assessed by BIA in nondiabetic HD patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Selçuklu School of Medicine, Selçuk University, Konya, Turkey. gulpericelik@gmail.com
authors.forename: Gülperi
authors.initials: G
authors.lastname: Çelik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yöntem
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cilo
authors.forename: Murat
authors.initials: M
authors.lastname: Bilge
authors.forename: İdris
authors.initials: İ
authors.lastname: Mehmetoğlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ünaldi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D044342:Malnutrition / Q000097:blood / Q000201:enzymology; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D006435:Renal Dialysis / Q000379:methods*; D014511:Uremia / Q000097:blood / Q000201:enzymology* / Q000628:therapy*; D055815:Young Adult
chemical_list: D005979:Glutathione Peroxidase