title: Neurodegeneration the RNA way.
abstract: The expression, processing, transport and activities of both coding and non-coding RNAs play critical roles in normal neuronal function and differentiation. Over the past decade, these same pathways have come under scrutiny as potential contributors to neurodegenerative disease. Here we focus broadly on the roles of RNA and RNA processing in neurodegeneration. We first discuss a set of "RNAopathies", where non-coding repeat expansions drive pathogenesis through a surprisingly diverse set of mechanisms. We next explore an emerging class of "RNA binding proteinopathies" where redistribution and aggregation of the RNA binding proteins TDP-43 or FUS contribute to a potentially broad range of neurodegenerative disorders. Lastly, we delve into the potential contributions of alterations in both short and long non-coding RNAs to neurodegenerative illness.
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, 4005 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
authors.forename: Abigail J
authors.initials: AJ
authors.lastname: Renoux
authors.forename: Peter K
authors.initials: PK
authors.lastname: Todd
mesh_terms: D000818:Animals; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000503:physiopathology*; D012313:RNA; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D016601:RNA-Binding Proteins; D012313:RNA
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