title: Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.
abstract: Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
authors.affiliation: Department of Biopathology, University of Tor Vergata, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Ottone
authors.forename: L
authors.initials: L
authors.lastname: Cicconi
authors.forename: S K
authors.initials: SK
authors.lastname: Hasan
authors.forename: S
authors.initials: S
authors.lastname: Lavorgna
authors.forename: M
authors.initials: M
authors.lastname: Divona
authors.forename: M T
authors.initials: MT
authors.lastname: Voso
authors.forename: E
authors.initials: E
authors.lastname: Montefusco
authors.forename: L
authors.initials: L
authors.lastname: Melillo
authors.forename: E
authors.initials: E
authors.lastname: Barragán
authors.forename: U
authors.initials: U
authors.lastname: Platzbecker
authors.forename: L
authors.initials: L
authors.lastname: Giannì
authors.forename: M
authors.initials: M
authors.lastname: Hubmann
authors.forename: M
authors.initials: M
authors.lastname: Pagoni
authors.forename: S
authors.initials: S
authors.lastname: Amadori
authors.forename: F
authors.initials: F
authors.lastname: Lo-Coco
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics; D000090205:DNA Methyltransferase 3A; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D049308:Dioxygenases; D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D015473:Leukemia, Promyelocytic, Acute / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011878:Radiotherapy / Q000009:adverse effects; D055815:Young Adult; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; C000717967:DNMT3A protein, human; D011518:Proto-Oncogene Proteins; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3