title: The impact of transsphenoidal surgery on glucose homeostasis and insulin resistance in acromegaly.
abstract: OBJECTIVE
  Impaired glucose tolerance and overt diabetes mellitus are frequently associated with acro-megaly. The aim of this study was to find out whether these alterations could be reversed after transsphenoidal surgery.
  
  
  METHODS
  Two hundred and thirty-nine acromegalic patients were studied before and 6-12 months after transsphenoidal surgery. Diagnosis of active acromegaly was established on the basis of widely recognized criteria. In each patient, glucose and insulin concentrations were assessed during the 75 γ oral glucose tolerance test (OGTT). To estimate insulin resistance, we used homeostasis model assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI).
  
  
  RESULTS
  At the moment of diagnosis, diabetes mellitus was present in 25% of the acromegalic patients. After surgery, the pre-valence of diabetes mellitus normalized to the level present in the general Polish population. We found a statistically significant reduction after surgery in plasma glucose levels both fasting (89.45 ± 13.92 mg/dL vs. 99.12 ± 17.33 mg/dL, p < 0.001) and during OGTT. Similarly, a prominent reduction in insulin secretion was found after surgery compared to the moment of diagnosis (15.44 ± 8.80 mIU/mL vs. 23.40 ± 10.24 mIU/mL, p < 0.001). After transsphenoidal surgery, there was a significant reduction in HOMA-IR (3.08 vs. 6.76, p < 0.0001) and a significant increase in QUICKI (0.32 vs. 0.29, p < 0.001). There were no statistically significant differences after surgery in fasting glucose and insulin levels between patients with controlled and in-adequately controlled disease.
  
  
  CONCLUSIONS
  We conclude that in acromegalic patients glucose homeostasis alterations and insulin sensitivity can be normalized after transsphenoidal surgery, even if strict biochemical cure criteria are not fulfilled.
authors.affiliation: Klinika Endokrynologii, Centrum Medycznego Kształcenia Podyplomowego, 01-809 Warszawa. mstelm@cmkp.edu.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Stelmachowska-Banaś
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Zieliński
authors.forename: Piotr
authors.initials: P
authors.lastname: Zdunowski
authors.forename: Jan
authors.initials: J
authors.lastname: Podgórski
authors.forename: Wocjiech
authors.initials: W
authors.lastname: Zgliczyński
mesh_terms: D000172:Acromegaly / Q000453:epidemiology / Q000601:surgery*; D000236:Adenoma / Q000453:epidemiology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult