title: Absolute blood eosinophil count and 1-year mortality risk following hospitalization with acute heart failure.
abstract: OBJECTIVE
  In acute heart failure (AHF), hemoglobin, red cell distribution width, mean platelet volume, leukocytes, and relative lymphocyte count have been associated with mortality. It is not known whether absolute blood neutrophil, eosinophil, and monocyte counts are mortality predictors.
  
  
  METHODS
  One hundred and seventy-six patients hospitalized due to AHF were enrolled. Treatment modalities and comorbidities influencing leukocyte counts were excluded. Hemogram, pro-brain natriuretic peptide, D-dimer, biochemistry, thyroid hormones, sensitive C-reactive protein, and echocardiography were obtained. Cardiovascular deaths during the first year after hospitalization were determined.
  
  
  RESULTS
  Leukocyte and absolute neutrophil count were significantly higher and absolute lymphocyte count and absolute eosinophil count (AEC) were significantly lower in deceased patients than patients who survived. Groups were similar in terms of monocyte counts. BMI albumin, estimated glomerular filtration rate, free T3, ejection fraction were significantly lower, and ferritin, uric acid, D-dimer, pro-brain natriuretic peptide were significantly higher in deceased patients. Mitral regurgitation, hypotension, hyponatremia, and acute renal failure were also significantly more frequent among the deceased group. Binary logistic regression analysis employing significant variables showed that lower BMI, lower ejection fraction, hyponatremia, lower free T3, and lower AEC were independent predictors of death and as a whole were responsible from 81.8% of cardiovascular deaths. Death rate among patients with an AEC of 0.02 n/l×10 or less was 4.4-fold higher than patients with an AEC of more than 0.02 n/l×10.
  
  
  CONCLUSIONS
  AEC of AHF patients measured at admission was found to be a stronger predictor of mortality than all other hemogram parameters and this is consistent with the increased sympatho-adrenal activity theory.
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Fatih, Istanbul, Turkey. malicikrikcioglu@yahoo.com
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Cikrikcioglu
authors.forename: Pinar
authors.initials: P
authors.lastname: Soysal
authors.forename: Digdem
authors.initials: D
authors.lastname: Dikerdem
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakirca
authors.forename: Rumeyza
authors.initials: R
authors.lastname: Kazancioglu
authors.forename: Servet
authors.initials: S
authors.lastname: Yolbas
authors.forename: Hafize
authors.initials: H
authors.lastname: Erkal
authors.forename: Mehmet
authors.initials: M
authors.lastname: Hursitoglu
authors.forename: Tulin Kurt
authors.initials: TK
authors.lastname: Karakose
authors.forename: Muharrem
authors.initials: M
authors.lastname: Kiskac
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akkaya
authors.forename: Mehmet
authors.initials: M
authors.lastname: Zorlu
authors.forename: Muhammed Emin
authors.initials: ME
authors.lastname: Akkoyunlu
authors.forename: Tufan
authors.initials: T
authors.lastname: Tukek
mesh_terms: D000208:Acute Disease; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D004804:Eosinophils; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000401:mortality*; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000097:blood; D007958:Leukocyte Count / Q000706:statistics & numerical data*; D008297:Male; D016017:Odds Ratio; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods; D013223:Statistics as Topic; D018709:Statistics, Nonparametric
chemical_list: D002097:C-Reactive Protein