title: The level of arabinitol in autistic children after probiotic therapy.
abstract: OBJECTIVE
  The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied.
  
  
  METHODS
  DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy.
  
  
  RESULTS
  The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders.
  
  
  CONCLUSIONS
  The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism.
authors.affiliation: Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland. jkaluzna@p.lodz.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Kałużna-Czaplińska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Błaszczyk
mesh_terms: D001288:Attention / Q000187:drug effects; D001321:Autistic Disorder / Q000150:complications / Q000628:therapy* / Q000652:urine; D002177:Candidiasis / Q000150:complications / Q000628:therapy* / Q000652:urine; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D019587:Dietary Supplements; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007536:Isomerism; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*; D013402:Sugar Alcohols / Q000652:urine*
chemical_list: D013402:Sugar Alcohols; C014999:arabitol