title: Synthesis of novel quinoxalinone derivatives by conventional and microwave methods and assessing their biological activity.
abstract: In this study, twenty-one arylaminoquinoxalinone derivatives were synthesized and their antibacterial activities against Staphylococci aureus, Pseudomonas aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Shigella pneumoniae were evaluated relative to known antibiotics; augmentin, ampicillin, and chloramphenicol. The insecticidal activities of the prepared compounds were also investigated against Tribolium castaneum using permethrin as a standard insecticide. The derivatives were synthesized using both conventional and microwave techniques. Their structures were confirmed using spectral techniques and elemental analysis.
authors.affiliation: Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.
authors.forename: Waqar
authors.initials: W
authors.lastname: Nasir
authors.forename: Munawar Ali
authors.initials: MA
authors.lastname: Munawar
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Ahsan
authors.initials: A
authors.lastname: Sharif
authors.forename: Saeed
authors.initials: S
authors.lastname: Ahmed
authors.forename: Amjad
authors.initials: A
authors.lastname: Ayub
authors.forename: Misbahul Ain
authors.initials: MA
authors.lastname: Khan
authors.forename: Faizul Hassan
authors.initials: FH
authors.lastname: Nasim
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001517:Coleoptera; D006540:Herbicides / Q000138:chemical synthesis / Q000494:pharmacology; D007202:Indicators and Reagents; D007306:Insecticides / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012639:Seeds / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D006540:Herbicides; D007202:Indicators and Reagents; D007306:Insecticides; D011810:Quinoxalines