title: New driver for lipid synthesis.
abstract: Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. These findings suggest a link between lipid synthesis and cellular pathways involved in methylation.
authors.affiliation: Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. s.m.houten@amc.uva.nl
authors.forename: Sander M
authors.initials: SM
authors.lastname: Houten
authors.forename: Carmen A
authors.initials: CA
authors.lastname: Argmann