title: Elevated plasma platelet-activating factor acetylhydrolase activity and its relationship to the presence of coronary artery disease.
abstract: BACKGROUND
  Platelet-activating factor acetylhydrolase (PAF-AH) is a circulating enzyme that has an important role in the development of coronary artery disease (CAD). The correlations between PAF-AH and CAD are controversial. Furthermore, the differences of the enzyme levels between patients with stable and unstable CAD are not fully determined. The purpose of this study was to evaluate plasma PAF-AH levels and its association with the presence of CAD and some clinical risk factors in the patients.
  
  
  METHODS
  This case-control study included 50 control subjects without CAD, 50 stable CAD patients and 50 unstable CAD patients with angiographically documented CAD. Plasma PAF-AH activity was determined by a commercial kit. The inflammatory markers, high sensitivity C-reactive protein (hsCRP) and oxidized low density lipoprotein (ox-LDL), and lipid profile were also measured. Comparisons of biochemical risk factors among all groups were performed by one way ANOVA. The association of PAF-AH activity with the presence of CAD was analyzed by multiple logistic regression.
  
  
  RESULTS
  Plasma PAF-AH activity levels were higher in unstable CAD patients (0.040 ± 0.012 μmol/min/ml) than in stable CAD patients (0.032 ± 0.010 μmol/min/ml) and control subjects (0.026 ± 0.009 μmol/min/ml) (p < 0.01). Plasma PAF-AH activity was also independently associated with the presence of CAD (p< 0.01).
  
  
  CONCLUSIONS
  Plasma PAF-AH activity levels were highly increased in unstable and stable CAD patients as compared to control subjects and may be a useful biomarker for CAD prediction.
authors.affiliation: Assistant Professor, Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Saedziaaldin
authors.initials: S
authors.lastname: Samsamshariat
authors.forename: Gholam
authors.initials: G
authors.lastname: Basati
authors.forename: Ahmad
authors.initials: A
authors.lastname: Movahedian
authors.forename: Morteza
authors.initials: M
authors.lastname: Pourfarzam
authors.forename: Nizal
authors.initials: N
authors.lastname: Sarrafzadegan
references.citation: Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2909-17
references.pmid: 10591668
references.citation: Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1172-8
references.pmid: 18356553
references.citation: Eur Heart J. 2007 Mar;28(6):699-704
references.pmid: 17314110
references.citation: Circulation. 2004 Oct 5;110(14):1903-8
references.pmid: 15451783
references.citation: Atherosclerosis. 2000 Jun;150(2):413-9
references.pmid: 10856534
references.citation: Eur J Intern Med. 2004 Aug;15(5):291-297
references.pmid: 15450986
references.citation: Am J Cardiol. 1990 Jan 1;65(1):1-5
references.pmid: 2294675
references.citation: Cardiol Rev. 2009 Sep-Oct;17(5):222-9
references.pmid: 19690473
references.citation: Expert Rev Cardiovasc Ther. 2010 Mar;8(3):425-38
references.pmid: 20222820
references.citation: Biochim Biophys Acta. 1994 Jun 23;1213(1):34-8
references.pmid: 8011677
references.citation: Mayo Clin Proc. 2007 Feb;82(2):159-65
references.pmid: 17290721
references.citation: Curr Atheroscler Rep. 2010 Mar;12(2):140-4
references.pmid: 20425250
references.citation: Diabetes Res Clin Pract. 2003 Mar;59(3):219-24
references.pmid: 12590019
references.citation: East Mediterr Health J. 2009 Jan-Feb;15(1):157-66
references.pmid: 19469439
references.citation: J Lipid Res. 2003 Jul;44(7):1381-6
references.pmid: 12730297
references.citation: N Engl J Med. 2004 Apr 1;350(14):1387-97
references.pmid: 15070788
references.citation: Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2523-9
references.pmid: 16960105
references.citation: Atherosclerosis. 2000 May;150(1):209-16
references.pmid: 10781653
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: Arterioscler Thromb Vasc Biol. 2005 May;25(5):923-31
references.pmid: 15731492
references.citation: Circulation. 2006 Apr 11;113(14):1745-52
references.pmid: 16537575
references.citation: Tex Heart Inst J. 2010;37(1):25-39
references.pmid: 20200624
references.citation: FEBS Lett. 2001 Sep 21;505(3):357-63
references.pmid: 11576528
references.citation: Expert Rev Mol Diagn. 2002 Jan;2(1):17-22
references.pmid: 11963798
references.citation: Metabolism. 1998 Feb;47(2):177-81
references.pmid: 9472966