title: Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang.
abstract: OBJECTIVE
  To explore the association between polymorphism of the human leukocyte antigen G (HLA-G) and susceptibility of esophageal carcinoma (EC) in Kazakh and Han nationality in Xinjiang.
  
  
  METHODS
  The 14 bp deletion/insertion (rs16375) and 0105N (rs41557518) of HLA-G genotyping were determined by PCR and PCR-RFLP, respectively in 239 patients and 467 controls.
  
  
  RESULTS
  There was a 2.69-fold (P(c) = 0.04, 95% CI: 1.30-5.55) increased risk of developing EC in individuals with the -14 bp/-14 bp genotype (rs16375) compared with those carrying +14 bp/+14 bp genotype in Kazakh after Bonferroni correction, there was no association of 0105N (rs41557518) both in Kazak and Han population. And there was a 2.82-fold (P(c) = 0.04, 95% CI: 1.32-6.04) increased risk of developing EC in individuals with -14 bp/-14 bp and C/C genotypes compared with those who had +14 bp/+14 bp and C/C genotypes in Kazakh.
  
  
  CONCLUSIONS
  The study demonstrates that EC is associated with polymorphism of HLA-G14 bp in Chinese Kazak population. The 14 bp deletion/insertion of HLA-G gene may play a role in EC susceptibility of Kazakh.
authors.affiliation: Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, China. y.chen92@gmail.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiu-jing
authors.initials: XJ
authors.lastname: Gao
authors.forename: Yan-chao
authors.initials: YC
authors.lastname: Deng
authors.forename: Hui-xia
authors.initials: HX
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D059951:HLA-G Antigens