title: OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings.
abstract: The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.
authors.affiliation: Department of Advanced Research and Development, OrbusNeich Medical, Inc. 5363 NW 35th Ave, Fort Lauderdale, FL 33309, USA. rcottone@orbusneich.com
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Cottone
authors.forename: G Lawrence
authors.initials: GL
authors.lastname: Thatcher
authors.forename: Sherry P
authors.initials: SP
authors.lastname: Parker
authors.forename: Laurence
authors.initials: L
authors.lastname: Hanks
authors.forename: David A
authors.initials: DA
authors.lastname: Kujawa
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Rowland
authors.forename: Marco
authors.initials: M
authors.lastname: Costa
authors.forename: Robert S
authors.initials: RS
authors.lastname: Schwartz
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
mesh_terms: D020341:Absorbable Implants; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation*; D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D011108:Polymers / Q000737:chemistry*; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage; D013234:Stem Cells / Q000473:pathology; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D011108:Polymers; D020123:Sirolimus