title: Acute phase protein response in the capybara (Hydrochoerus hydrochaeris).
abstract: We evaluated the acute phase protein response in capybaras (Hydrochoerus hydrochaeris). Three animal groups were used: 1) healthy animals (n=30), 2) a group in which experimental inflammation with turpentine was induced (n=6), and 3) a group affected with sarcoptic scabies (n=14) in which 10 animals were treated with ivermectin. Haptoglobin (Hp), acid-soluble glycoprotein (ASG) and albumin were analyzed in all animals. In those treated with turpentine, Hp reached its maximum value at 2 wk with a 2.7-fold increase, whereas ASG increased 1.75-fold and albumin decreased 0.87-fold 1 wk after the induction of inflammation. Capybaras affected with sarcoptic scabies presented increases in Hp and ASG of 4.98- and 3.18-fold, respectively, and a 0.87-fold decrease in albumin, compared with healthy animals. Haptoglobin and ASG can be considered as moderate, positive acute phase proteins in capybaras because they showed less than 10-fold increases after an inflammatory process and reached their peak concentrations 1 wk after the induction of inflammation. Conversely, albumin can be considered a negative acute phase protein in capybaras because it showed a reduction in concentration after inflammatory stimulus.
authors.affiliation: Animal Medicine and Surgery Department, University of Murcia, Hospital Clínico Veterinario 4 planta, Campus de Espinardo s/n, 30100 Espinardo (Murcia), Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Bernal
authors.forename: Mariane
authors.initials: M
authors.lastname: Feser
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: Juan D
authors.initials: JD
authors.lastname: García-Martínez
authors.forename: José J
authors.initials: JJ
authors.lastname: Cerón
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D011897:Random Allocation; D012376:Rodent Diseases / Q000378:metabolism*; D012377:Rodentia / Q000378:metabolism*; D012520:Sarcoptes scabiei / Q000276:immunology; D012532:Scabies / Q000378:metabolism / Q000662:veterinary*; D012709:Serum Albumin / Q000378:metabolism; D014425:Turpentine / Q000633:toxicity
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D006023:Glycoproteins; D006242:Haptoglobins; D012709:Serum Albumin; D014425:Turpentine