title: Pamidronate infusion improved two cases of intractable seronegative rheumatoid arthritise.
abstract: Pamidronate is a bisphosphonate derivative that can inhibit bone resorption by actions on osteoclasts and increase bone density in spite of treatment with steroids. This drug has the anti-inflammatory effect by increase apoptosis of monocytes. 5-10 percent of rheumatoid arthritis patients is seronegative and may be resistant to conventional disease modifying anti rheumatic drugs (DMARDs). Intravenous (IV) pamidronate can be effective in disease control in seronegative rheumatoid arthritis. We report two cases of seronegative and drug resistant rheumatoid arthritis that favorably responds to pamidronate.
authors.affiliation: Assistant professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mansour
authors.initials: M
authors.lastname: Salesi
authors.forename: Peyman
authors.initials: P
authors.lastname: Mottaghi
references.citation: Ann Rheum Dis. 2011 Apr;70(4):583-9
references.pmid: 21330639
references.citation: J Rheumatol. 2004 Sep;31(9):1732-7
references.pmid: 15338492
references.citation: Clin Exp Rheumatol. 2001 Jan-Feb;19(1):13-20
references.pmid: 11247319
references.citation: Iran Biomed J. 2007 Jan;11(1):7-13
references.pmid: 18051699
references.citation: J Rheumatol. 1994 Nov;21(11):2016-20
references.pmid: 7869303
references.citation: Acta Oncol. 1996;35 Suppl 5:50-4
references.pmid: 9142965