title: [Prevention of peri-operative infection with sequential therapy of levofloxacin in patients undergoing laparoscopic hysterectomy, laparoscopic assisted vaginal hysterectomy and transvaginal hysterectomy].
abstract: OBJECTIVE
  To investigate the effect and safety of sequential therapy of levofloxacin in the prevention of peri-operative infections among patients undergoing laparoscopic hysterectomy (LH), laparoscopic assisted vaginal hysterectomy (LAVH) and transvaginal hysterectomy (TVH).
  
  
  METHODS
  During 2009 - 2010, a total of 50 patients with the indications for LH, LAVH or TVH at our hospital were recruited. Their age range was 18 - 65 years old. In fair general conditions, they had no severe infection of female reproductive system. Levofloxacin 500 mg was administered by an intravenous injection once daily and then orally once daily.
  
  
  RESULTS
  The average duration of intravenous injection of levofloxacin was 4.3 days while and the duration of its oral administration 4.5 days. No infection was seen in 48 patients with an efficient prevention rate of 96.0%. Only 1 patient showed mild gastroenterological reactions. The side reaction rate was 2.0%.
  
  
  CONCLUSIONS
  The sequential therapy of levofloxacin is both effective and safe in the prevention of peri-operative infections among patients undergoing LH, LAVH and TVH.
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, China.
authors.forename: Jin-hui
authors.initials: JH
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Zhu
authors.forename: Zhi-jing
authors.initials: ZJ
authors.lastname: Sun
authors.forename: Lei
authors.initials: L
authors.lastname: Li
mesh_terms: D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D007432:Intraoperative Period; D064704:Levofloxacin; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D064704:Levofloxacin; D015242:Ofloxacin