title: [Magnetic resonance imaging findings of lesions in limbic system related structures in general paresis of insane].
abstract: OBJECTIVE
  To analyze the magnetic resonance imaging (MRI) findings of lesions in the limbic system related structures in general paresis of insane (GPI) patients so as to explore its pathogenesis and provide a new MRI diagnostic method.
  
  
  METHODS
  The clinical data and MRI findings of lesions in the limbic system related structures were retrospectively analyzed for a total of 31 GPI patients. The parameters were volume and signal abnormality.
  
  
  RESULTS
  On MRI, structural abnormalities were found in amygdaloid body (n = 29), hippocampus (n = 28), insular lobe (n = 24), parahippocampal gyrus (n = 23), lenticular nucleus (n = 23), corpus callosum (n = 20), caudate nucleus (n = 11), hypothalamus (n = 10), anterior nucleus of thalamus (n = 10), cingulate gyrus (n = 8) and thalamus (n = 2). The frequent manifestations were atrophy, swelling, T2 hyperintensity in various structures and T2 hypointensity in lenticular nucleus.
  
  
  CONCLUSIONS
  A frequent involvement of limbic system structures in GPI patients may be related with dementia and other psychiatric symptoms. Swelling and T2 hyperintensity of involved structures may be the characteristic MRI manifestations of GPI.
authors.affiliation: Department of Radiology, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.forename: Shao-qiong
authors.initials: SQ
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Shan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Zhang
authors.forename: Xiu-zhen
authors.initials: XZ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008032:Limbic System / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000473:pathology*; D012189:Retrospective Studies