title: Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury.
abstract: Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.
authors.affiliation: Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA.
authors.forename: Amy E B
authors.initials: AE
authors.lastname: Packard
authors.forename: Jason C
authors.initials: JC
authors.lastname: Hedges
authors.forename: Frances R
authors.initials: FR
authors.lastname: Bahjat
authors.forename: Susan L
authors.initials: SL
authors.lastname: Stevens
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Conlin
authors.forename: Andres M
authors.initials: AM
authors.lastname: Salazar
authors.forename: Mary P
authors.initials: MP
authors.lastname: Stenzel-Poore
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D002478:Cells, Cultured; D016207:Cytokines / Q000097:blood; D007369:Interferon Inducers / Q000627:therapeutic use*; D019194:Ischemic Preconditioning / Q000379:methods*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011070:Poly I-C / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D016207:Cytokines; D007369:Interferon Inducers; D018696:Neuroprotective Agents; D011070:Poly I-C
references.citation: Anesthesiology. 2008 Jan;108(1):18-30
references.pmid: 18156878
references.citation: Kidney Int. 2004 Feb;65(2):713-8
references.pmid: 14717946
references.citation: J Cereb Blood Flow Metab. 2007 Oct;27(10):1663-74
references.pmid: 17327883
references.citation: J Neurosci. 2009 Aug 5;29(31):9839-49
references.pmid: 19657036
references.citation: Neurol Res. 1997 Dec;19(6):641-8
references.pmid: 9427967
references.citation: Am J Cardiol. 2010 Dec 15;106(12):1728-34
references.pmid: 21126617
references.citation: J Neurosci Methods. 2002 Jun 30;117(2):207-14
references.pmid: 12100987
references.citation: J Cereb Blood Flow Metab. 2008 May;28(5):1040-7
references.pmid: 18183029
references.citation: Stroke. 2008 May;39(5):1427-33
references.pmid: 18323490
references.citation: Neuro Oncol. 2010 Oct;12(10):1071-7
references.pmid: 20615924
references.citation: Trends Neurosci. 2003 May;26(5):248-54
references.pmid: 12744841
references.citation: Antivir Chem Chemother. 2005;16(2):91-102
references.pmid: 15889532
references.citation: Am J Pathol. 2000 Jan;156(1):287-93
references.pmid: 10623677
references.citation: Transpl Int. 2007 Mar;20(3):219-29
references.pmid: 17291215
references.citation: Surg Today. 2004;34(1):11-5
references.pmid: 14714222