title: Stage of hepatocellular carcinoma is associated with periodontitis.
abstract: OBJECTIVE
  Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis.
  
  
  METHODS
  We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels.
  
  
  RESULTS
  The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p < 0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p < 0.001).
  
  
  CONCLUSIONS
  HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.
authors.affiliation: Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Tamaki
authors.forename: Akinobu
authors.initials: A
authors.lastname: Takaki
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tomofuji
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Endo
authors.forename: Kenta
authors.initials: K
authors.lastname: Kasuyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ekuni
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yasunaka
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Morita
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017382:Reactive Oxygen Species / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D017382:Reactive Oxygen Species