title: CYP8A1 gene polymorphisms and left main coronary artery disease.
abstract: BACKGROUND
  Left main (LM) disease is rare but the most hazardous phenotype of coronary artery disease (CAD). Thus, early detection of participants at high risk of developing left main coronary heart disease (LM-CAD) is crucial. The aim of this study was to identify gene polymorphisms which could distinguish participants who are at high risk of developing LM-CAD. Such a candidate can be the prostaglandin I(2) or prostacyclin (PGI(2)) gene.
  
  
  METHODS
  The DNA of 254 participants (151 participants with angiographically documented LM-CAD and 103 healthy controls) was analyzed for the frequency of C1117A polymorphism in the gene coding CYP8A1.
  
  
  RESULTS
  The genotype distribution was different between the LM-CAD and the control group. Particularly, the CC genotype of CYP8A1 was commoner in the LM-CAD than in the healthy group (P < .001). Allele frequencies were also differently distributed between the 2 groups. C allele frequency was higher in LM-CAD group (P = .016).
  
  
  CONCLUSIONS
  The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD, which prospectively may have potential importance in screening high-risk populations. However, further investigations in larger populations are required to confirm these findings.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Bousoula
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vasiliadis
authors.forename: Agathi
authors.initials: A
authors.lastname: Karakosta
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
authors.forename: Elizabeth O
authors.initials: EO
authors.lastname: Johnson
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Skandalakis
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase