title: Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002-2006.
abstract: BACKGROUND
  Recent trends indicate a change in the epidemiology of inflammatory bowel diseases (IBD), with previously low incidence areas now reporting a progressive rise in the incidence. Our aim was to analyze the incidence and disease phenotype at diagnosis in IBD in the population-based Veszprem Province database, which included incident patients diagnosed between January 1, 2002 and December 31, 2006.
  
  
  METHODS
  Data of 393 incident patients were analyzed (ulcerative colitis [UC]: 220, age-at-diagnosis: 40.5 years; Crohn's disease [CD]: 163, age-at-diagnosis: 32.5 years; and indeterminate colitis [IC]: 10). Both hospital and outpatient records were collected and comprehensively reviewed.
  
  
  RESULTS
  Adjusted mean incidence rates were 8.9/10(5) person-years for CD and 11.9/10(5) person-years in UC. Peak onset age in both CD and UC patients was 21-30 years old. Location at diagnosis in UC was proctitis in 26.8%, left-sided colitis in 50.9%, and pancolitis in 22.3%. The probability of proximal extension and colectomy after 5 years was 12.7% and 2.8%. The disease location in CD was ileal in 20.2%, colonic in 35.6%, ileocolonic in 44.2%, and upper gastrointestinal in four patients. Behavior at diagnosis was stenosing/penetrating in 35.6% and perianal in 11.1%. Patients with colonic disease were older at diagnosis compared to patients with ileal or ileocolonic disease. In a Kaplan-Meier analysis, probability of surgical resection was 9.8%, 18.5%, and 21.3% after 1, 3, and 5 years of disease duration, respectively.
  
  
  CONCLUSIONS
  The incidence of IBD in Veszprem Province in the last decade was high, equal to that in high-incidence areas in Western European countries. Early disease course is milder compared to data reported in the literature.
authors.affiliation: Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Lakatos
authors.forename: Lajos S
authors.initials: LS
authors.lastname: Kiss
authors.forename: Gyula
authors.initials: G
authors.lastname: David
authors.forename: Tunde
authors.initials: T
authors.lastname: Pandur
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Erdelyi
authors.forename: Gabor
authors.initials: G
authors.lastname: Mester
authors.forename: Mihaly
authors.initials: M
authors.lastname: Balogh
authors.forename: Istvan
authors.initials: I
authors.lastname: Szipocs
authors.forename: Csaba
authors.initials: C
authors.lastname: Molnar
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Komaromi
authors.forename: Peter Laszlo
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D003424:Crohn Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult