title: [Synthesis and spectral characteristic of pharmaceutical dipfluzine hydrochloride-benzoic acid co-crystal].
abstract: Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient (API), which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates (pseudo-polymorphs). In our study, dipfluzine hydrochloride-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.
authors.affiliation: School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China. yang_caiqin@163.com
authors.forename: Cai-Qin
authors.initials: CQ
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Zhang
mesh_terms: D019817:Benzoic Acid; D002936:Cinnarizine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003460:Crystallization; D006860:Hydrogen Bonding; D013057:Spectrum Analysis
chemical_list: D002936:Cinnarizine; C065758:dipfluzine; D019817:Benzoic Acid