title: Quantitative comparative analysis of the bio-active and toxic constituents of leaves and spikes of Schizonepeta tenuifolia at different harvesting times.
abstract: A GC-MS-Selected Ion Monitoring (SIM) detection method was developed for simultaneous determination of four monoterpenes: (-)-menthone, (+)-pulegone, (-)-limonene and (+)-menthofuran as the main bio-active and toxic constituents, and four other main compounds in the volatile oils of Schizonepeta tenuifolia (ST) leaves and spikes at different harvesting times. The results showed that the method was simple, sensitive and reproducible, and that harvesting time was a possible key factor in influencing the quality of ST leaves, but not its spikes. The research might be helpful for determining the harvesting time of ST samples and establishing a validated method for the quality control of ST volatile oil and other relative products.
authors.affiliation: Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China; E-Mails:  yusheng1219@sina.com  (S.Y.);  owenchenlin@163.com  (Y.C.);  shanmingqiu@163.com  (M.S.);  yupingtang@njutcm.edu.cn  (Y.T.).
authors.forename: Sheng
authors.initials: S
authors.lastname: Yu
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Mingqiu
authors.initials: M
authors.lastname: Shan
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
authors.forename: Anwei
authors.initials: A
authors.lastname: Ding
mesh_terms: D000081005:Cyclohexane Monoterpenes; D008401:Gas Chromatography-Mass Spectrometry; D019686:Lamiaceae / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D008610:Menthol / Q000032:analysis; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000032:analysis* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D013997:Time Factors
chemical_list: D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D008610:Menthol; C039648:pulegone; C019466:menthone
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