title: Iron depletion: an ameliorating factor for sickle cell disease?
abstract: We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS in favor of HbF, possibly reducing the severity of the disease. We believe that it would be worthwhile to monitor the course of the disease comparing cases with identical genotypes with and without iron depletion, and we advise to consider chelation therapy to reduce iron overload in patients with SCD.
authors.affiliation: Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2300RC Leiden, The Netherlands.
authors.forename: P C
authors.initials: PC
authors.lastname: Giordano
authors.forename: W
authors.initials: W
authors.lastname: Huisman
authors.forename: C L
authors.initials: CL
authors.lastname: Harteveld
references.citation: Haematologica. 2006 Sep;91(9):1275-6
references.pmid: 16956833
references.citation: Hum Genet. 1988 Oct;80(2):157-60
references.pmid: 3169739
references.citation: Clin Biochem. 2009 Dec;42(18):1757-66
references.pmid: 19591814
references.citation: J Assoc Physicians India. 2002 Nov;50:1368-71
references.pmid: 12583463
references.citation: Haematologica. 2011 Jan;96(1):5-8
references.pmid: 21193427
references.citation: Haematologica. 2004 Oct;89(10):1172-8
references.pmid: 15477200
references.citation: Blood. 1995 Jul 15;86(2):776-83
references.pmid: 7606007
references.citation: Pharmacogenomics J. 2003;3(4):215-26
references.pmid: 12931135
references.citation: Haematologica. 2006 Aug;91(8):1076-83
references.pmid: 16885048
references.citation: Hemoglobin. 2000 Aug;24(3):259-63
references.pmid: 10975447
references.citation: Br J Haematol. 2010 Dec;151(5):425-9
references.pmid: 20955412