title: Allelic Diversity of Major Histocompatibility Complex Class II DRB Gene in Indian Cattle and Buffalo.
abstract: The present study was conducted to study the diversity of MHC-DRB3 alleles in Indian cattle and buffalo breeds. Previously reported BoLA-DRB exon 2 alleles of Indian Zebu cattle, Bos taurus cattle, buffalo, sheep, and goats were analyzed for the identities and divergence among various allele sequences. Comparison of predicted amino acid residues of DRB3 exon 2 alleles with similar alleles from other ruminants revealed considerable congruence in amino acid substitution pattern. These alleles showed a high degree of nucleotide and amino acid polymorphism at positions forming peptide-binding regions. A higher rate of nonsynonymous substitution was detected at the peptide-binding regions, indicating that BoLA-DRB3 allelic sequence evolution was driven by positive selection.
authors.affiliation: Animal Biotechnology Centre, National Dairy Research Institute, Karnal 1, Haryana 23001, India.
authors.forename: Sachinandan
authors.initials: S
authors.lastname: De
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Singh
authors.forename: Biswajit
authors.initials: B
authors.lastname: Brahma
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