title: Prediction of all-cause mortality by B group vitamin status in the elderly.
abstract: OBJECTIVE
  Little is known about the direct relationship of B vitamins to mortality in the elderly. All-cause mortality by vitamin B status, using dietary (B-1, B-2, niacin, B-6) or biochemical data (erythrocyte transketolase reductase, erythrocyte glutathione reductase, plasma pyridoxal-phosphate, folate and serum B-12) was evaluated.
  
  
  METHODS
  The Taiwanese Elderly Nutrition and Health Survey (1999-2000) provided 1747 participants 65 years and over. Dietary and biochemical data were collected at baseline. Survivorship was determined until December 31, 2008.
  
  
  RESULTS
  Survivors had higher vitamin B-1 and niacin intakes and pyridoxal-phosphate and folate concentrations. Controlled for confounders, and relative to the lowest tertile of vitamin B-1 or B-6 intakes, the hazard ratios (95% confidence interval) for tertile 3 were 0.74 (0.58-0.95) and 0.74 (0.57-0.97); both p for trend values were <0.05. Further adjustment for dietary diversity led to insignificant findings. For pyridoxal-phosphate, compared to those with deficiency levels, the multivariable-adjusted hazard ratios (95% confidence interval) for adequacy was 0.52 (0.38-0.71) with p for trend <0.0001 and unchanged with dietary diversity adjustment.
  
  
  CONCLUSIONS
  Higher vitamin B-1 and B-6 intakes and plasma pyridoxal-phosphate were associated with lower risk of mortality up to 10 years and could be achieved by increased dietary diversity.
authors.affiliation: Division of Health Services and Preventive Medicine, Institute of Population Health Sciences, National Health Research Institutes, No 35 Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC. yichen@nhri.org.tw
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Huang
authors.forename: Meei-Shyuan
authors.initials: MS
authors.lastname: Lee
authors.forename: Mark L
authors.initials: ML
authors.lastname: Wahlqvist
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009026:Mortality; D015999:Multivariate Analysis; D009525:Niacin / Q000097:blood; D009752:Nutritional Status; D011732:Pyridoxal Phosphate / Q000097:blood; D012256:Riboflavin / Q000008:administration & dosage / Q000097:blood; D013624:Taiwan / Q000453:epidemiology; D013831:Thiamine / Q000008:administration & dosage / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000097:blood; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000097:blood*; D014804:Vitamin B Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D014803:Vitamin B Complex; D009525:Niacin; D011732:Pyridoxal Phosphate; D025101:Vitamin B 6; D005492:Folic Acid; D014805:Vitamin B 12; D012256:Riboflavin; D013831:Thiamine