title: Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats.
abstract: An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo.
authors.affiliation: College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350108, China.
authors.forename: Mingqing
authors.initials: M
authors.lastname: Huang
authors.forename: Youliang
authors.initials: Y
authors.lastname: Xie
authors.forename: Lidian
authors.initials: L
authors.lastname: Chen
authors.forename: Kedan
authors.initials: K
authors.lastname: Chu
authors.forename: Shuisheng
authors.initials: S
authors.lastname: Wu
authors.forename: Jinjian
authors.initials: J
authors.lastname: Lu
authors.forename: Xiuping
authors.initials: X
authors.lastname: Chen
authors.forename: Yitao
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lai
mesh_terms: D000143:Acids / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001806:Blood Urea Nitrogen; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D059305:Diet, High-Fat / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013311:Streptozocin / Q000009:adverse effects
chemical_list: D000143:Acids; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D007328:Insulin; D010618:Phenanthrolines; D059808:Polyphenols; C028972:dan-shen root extract; D013311:Streptozocin