title: [Application of Susceptible-Infected-Recovered model in dealing with an outbreak of acute hemorrhagic conjunctivitis on one school campus].
abstract: To simulate intervention measures in controlling an outbreak of acute hemorrhagic conjunctivitis on one school campus by using the Susceptible-Infected-Recovered (SIR) model, to provide evidence for preparedness and response to the epidemic. Classical SIR model was used to model the epidemic. Malthusian exponential decline method was employed to estimate the infective coefficient β for interventions. The initial value of parameters was determined based on empirical data. The modeling was implemented using Matlab 7.1 software. Without interventions, the outbreak was expected to experience three phrases: (1) early stage (the first 5 days) in which the epidemic developed slowly and could be intervened easily; (2) rapid growing stage (6 - 15 days) in which the number of infected cases increased quickly and the epidemic could not be well controlled; and (3) medium and late stage (16 days and later) in which more than 90% of the susceptible persons were infected but the intervention measures failed to prevent the epidemic. With the implementation of interventions, the epidemic was predicted to be controlled in the early stage, under the SIR model. The simulation based on the SIR model kept an acceptable consistency with the actual development of epidemic after the implementation of intervention measures. The SIR model seemed effective in modeling interventions to the epidemic of acute hemorrhagic conjunctivitis in the schools.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Tian-mu
authors.initials: TM
authors.lastname: Chen
authors.forename: Ru-chun
authors.initials: RC
authors.lastname: Liu
authors.forename: Qi-qi
authors.initials: QQ
authors.lastname: Wang
authors.forename: Song-lin
authors.initials: SL
authors.lastname: Hu
authors.forename: Ai-chun
authors.initials: AC
authors.lastname: Tan
authors.forename: Qiong
authors.initials: Q
authors.lastname: He
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Guo-qing
authors.initials: GQ
authors.lastname: Hu
mesh_terms: D003232:Conjunctivitis, Acute Hemorrhagic / Q000175:diagnosis / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D008962:Models, Theoretical; D012574:Schools