title: Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines.
abstract: BACKGROUND
  Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.
  
  
  OBJECTIVE
  The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).
  
  
  METHODS
  The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice.
  
  
  RESULTS
  In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.
  
  
  CONCLUSIONS
  It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.
authors.affiliation: Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Jinglou
authors.initials: J
authors.lastname: Chen
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Lei
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wu
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.forename: Chaomei
authors.initials: C
authors.lastname: Xiong
authors.forename: Jinlan
authors.initials: J
authors.lastname: Ruan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D029624:Ferns; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D009569:Nitric Oxide / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D011192:Potassium Dichromate; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011692:Puromycin Aminonucleoside; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D008055:Lipids; D059808:Polyphenols; D020011:Protective Agents; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D009569:Nitric Oxide; D011692:Puromycin Aminonucleoside; D003404:Creatinine; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D011192:Potassium Dichromate