title: [Mucinous tubular and spindle cell carcinoma of kidney: a clinicopathological study].
abstract: OBJECTIVE
  To investigate the clinicopathological features, histogenesis and prognosis of mucinous tubular and spindle cell carcinoma (MTSCC).
  
  
  METHODS
  Five MTSCCs were studied with histochemical, immunohistochemical staining, electron microscopy, and review of the related literatures.
  
  
  RESULTS
  Four cases of MTSCC were females and one was male. Three patients presented with flank discomfort and two were incidentally found with health examination. In gross examination, the tumors were circumscribed. The cut surface was solid, gray-white, yellow or red. Necrosis was present in one case of high-grade MTSCC. Microscopically, low-grade MTSCC was mainly consisted of tubular, spindle cell and mucinous stroma with relatively bland morphology, and mitoses were rare. While in the high-grade area of one case, the cells were spindle or polymorphic with severe atypia and high mitotic activity, without mucinous stroma and tubular structure. Mucin was positive for Alcian blue. The neoplastic cells were positive for vimentin (5/5), CKpan (5/5), CK7 (5/5), CK19 (5/5), 34betaE12 (1/5), EMA (5/5), E-cadherin (3/5), CD10 (1/5), P504S (5/5), and CAM5.2 (5/5). The Ki-67 index was low (< or = 5%) in the low-grade component, while it was high (15%) in the high-grade component. Ultrastructural study showed short microvilli along glandular lumens. The nuclear membrane was focally invaginated. Four cases were followed up for 3 to 52 months, and recurrence and metastasis were not found.
  
  
  CONCLUSIONS
  MTSCC occurs predominantly in females and it is a rare kidney neoplasm. Most of MTSCCs are low-grade and the prognosis is relatively good. However, the patients of high-grade MTSCC should be closely followed up.
authors.affiliation: Department of Pathology, Nanjing General Hospital of People's Liberation Army, Nanjing 210002, China.
authors.forename: Hong-jie
authors.initials: HJ
authors.lastname: Song
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Hang-bo
authors.initials: HB
authors.lastname: Zhou
authors.forename: Heng-hui
authors.initials: HH
authors.lastname: Ma
authors.forename: Qun-li
authors.initials: QL
authors.lastname: Shi
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018276:Carcinoma, Medullary / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D007890:Leiomyosarcoma / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009392:Nephrectomy; D019998:Racemases and Epimerases / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: C121278:CK-34 beta E12; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase