title: Acellular dermal matrix allograft versus subepithelial connective tissue graft in treatment of gingival recessions: a 5-year randomized clinical study.
abstract: OBJECTIVE
  The present randomized clinical trial compared the long-term results of subepithelial connective tissue graft (SCTG) versus acellular dermal matrix allograft (ADMA) in treatment of gingival recessions.
  
  
  METHODS
  In 16 patients with bilateral Miller Class I/II gingival recessions, one side was treated with SCTG and the other side with ADMA. Clinical parameters were measured at baseline, 6 months, and at 5 years post-surgery.
  
  
  RESULTS
  Fifteen patients completed the study. At 6 months, all parameters showed significant improvement in ADMA and SCTG groups [complete root coverage (CRC): 73.3% versus 26.7%, p = 0.027; reduction of recession depth (RD): 2.6 ± 1.1 mm versus 2.2 ± 1.1 mm, p = 0.376; reduction of recession width (RW): 3.0 ± 1.4 mm versus 2.4 ± 1.4 mm, p = 0.207 respectively]. At 5 years, significant relapses were detected in CRC and reduction of RD and RW in both groups with no statistically significant difference (CRC: 20.0% versus 13.3%, p = 1.00; RD: 1.6 ± 1.2 mm versus 1.5 ± 1.4mm, p = 0.838; RW: 1.8 ± 1.4 mm versus 1.3 ± 1.5mm, p = 0.367). Patients practicing horizontal toothbrushing habit showed more relapse (OR = 11.2; p = 0.01). Compared with baseline, the gingival width (GW) did not increase in ADMA-treated sites (p = 0.903).
  
  
  CONCLUSIONS
  Five-year results of SCTG and ADMA were similar in terms of CRC and reduction of RD and RW. Both techniques showed a significant relapse associated with returning to horizontal toothbrushing habit. Increase of GW was stable in SCTG-treated sites, but reached to pre-surgical values in ADMA-treated cases.
authors.affiliation: Laser Research Center in Dentistry, Dental Research Center, Periodontics Department, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Moslemi
authors.forename: Mahvash
authors.initials: M
authors.lastname: Mousavi Jazi
authors.forename: Farideh
authors.initials: F
authors.lastname: Haghighati
authors.forename: Seyyedeh Pouya
authors.initials: SP
authors.lastname: Morovati
authors.forename: Raika
authors.initials: R
authors.lastname: Jamali
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use; D003238:Connective Tissue / Q000637:transplantation; D003774:Dental Plaque Index; D005500:Follow-Up Studies; D005881:Gingiva / Q000601:surgery; D005889:Gingival Recession / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D010512:Periodontal Index; D012008:Recurrence; D013524:Surgical Flaps; D014099:Toothbrushing / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen