title: Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: a case report.
abstract: Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.
authors.affiliation: Department of Nephrology, Cork University Hospital, Wilton, Cork, Ireland. marek.mazur@hse.ie
authors.forename: M J
authors.initials: MJ
authors.lastname: Mazur
authors.forename: A C
authors.initials: AC
authors.lastname: Lowney
authors.forename: J
authors.initials: J
authors.lastname: Prigoff
authors.forename: R L
authors.initials: RL
authors.lastname: Heilman
authors.forename: H
authors.initials: H
authors.lastname: Chakkera
authors.forename: A
authors.initials: A
authors.lastname: Moss
authors.forename: D
authors.initials: D
authors.lastname: Mulligan
authors.forename: K
authors.initials: K
authors.lastname: Reddy
authors.forename: K
authors.initials: K
authors.lastname: Hamawi
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation; D016030:Kidney Transplantation / Q000379:methods; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000150:complications / Q000628:therapy*; D016035:Pancreas Transplantation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents