title: Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse.
abstract: Tenascin-X (Tn-X) belongs to the tenascin family of glycoproteins and has been reported to be significantly associated with schizophrenia in a single nucleotide polymorphism analysis in humans. This finding indicates an important role of Tn-X in the central nervous system (CNS). However, details of Tn-X localization are not clear in the primate CNS. Using immunohistochemical techniques, we found novel localizations of Tn-X in the interstitial connective tissue and around blood vessels in the choroid plexus (CP) in macaque monkeys. To verify the reliability of Tn-X localization, we compared the Tn-X localization with the tenascin-C (Tn-C) localization in corresponding regions using neighbouring sections. Localization of Tn-C was not observed in CP. This result indicated consistently restricted localization of Tn-X in CP. Comparative investigations using mouse tissues showed equivalent results. Our observations provide possible insight into specific roles of Tn-X in CP for mammalian CNS function.
authors.affiliation: Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, Japan. imurako@tky.ndu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Imura
authors.forename: I
authors.initials: I
authors.lastname: Sato
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism*; D000882:Haplorhini; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000378:metabolism; D019063:Tenascin / Q000378:metabolism*
chemical_list: D019063:Tenascin; C081865:tenascin X
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