title: Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by 'click chemistry'.
abstract: Novel analogs of SGLT2 inhibitors containing the 1,2,3-triazole motif were designed and synthesized for urinary glucose excretion evaluation. The C-glucosides with triazole aglycone can be easily constructed by click chemistry. Most of the synthesized compounds increased urinary glucose excretion and demonstrated inhibition of glucose transport.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Lan-Tao
authors.initials: LT
authors.lastname: Li
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Zhou
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001692:Biological Transport; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D057930:Click Chemistry / Q000379:methods; D003920:Diabetes Mellitus / Q000188:drug therapy; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008956:Models, Chemical; D051381:Rats; D017207:Rats, Sprague-Dawley; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013997:Time Factors; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D014230:Triazoles; D005947:Glucose