title: Antioxidant and vasodilatory effects of blackberry and grape wines.
abstract: In contrast to the well-described various biological effects of grape wines, the potential effects of commonly consumed blackberry wine have not been studied. We examined in vitro antioxidant and vasodilatory effects of four blackberry wines and compared them with the effects of two red and two white grape wines. Although some blackberry wines had lower total phenolic content relative to the red grape wines, their antioxidant capacity was stronger, which may be related to a higher content of non-flavonoid compounds (most notably gallic acid) in blackberry wines. Although maximal vasodilation induced by blackberry wines was generally similar to that of red wines, blackberry wines were less potent vasodilators. Vasodilatory activity of all wines, in addition to their flavonoid and total phenolic content, was most significantly associated with their content of anthocyanins. No association of vasodilation with any individual polyphenolic compound was found. Our results indicate the biological potential of blackberry wines, which deserves deeper scientific attention.
authors.affiliation: Department of Pharmacology, University of Split School of Medicine, Split, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Mudnic
authors.forename: Danijela
authors.initials: D
authors.lastname: Budimir
authors.forename: Darko
authors.initials: D
authors.lastname: Modun
authors.forename: Grgo
authors.initials: G
authors.lastname: Gunjaca
authors.forename: Ivana
authors.initials: I
authors.lastname: Generalic
authors.forename: Danijela
authors.initials: D
authors.lastname: Skroza
authors.forename: Visnja
authors.initials: V
authors.lastname: Katalinic
authors.forename: Ivica
authors.initials: I
authors.lastname: Ljubenkov
authors.forename: Mladen
authors.initials: M
authors.lastname: Boban
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000032:analysis / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000032:analysis; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D005707:Gallic Acid / Q000032:analysis / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000032:analysis* / Q000494:pharmacology; D027843:Vitis / Q000737:chemistry*; D014920:Wine / Q000032:analysis*
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D014665:Vasodilator Agents; D000431:Ethanol; D005707:Gallic Acid
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