title: The effect of coenzyme Q₁₀ supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study.
abstract: OBJECTIVE
  It has been shown that coenzyme Q(10) (CoQ(10)) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ(10) supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT.
  
  
  METHODS
  Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ(10) 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ(10) discontinuation.
  
  
  RESULTS
  Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ(10) therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.
  
  
  CONCLUSIONS
  CoQ(10) supplementation improves semen quality with beneficial effect on pregnancy rate.
authors.affiliation: Clinical Center for Urological Disease Diagnosis, Private Clinic Specialized in Urological and Andrological Genetics, PO Box 19395-1849, Tehran, Iran. safarinejad@urologist.md
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Safarinejad
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D007265:Inhibins / Q000097:blood / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood / Q000187:drug effects; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011388:Prolactin / Q000097:blood / Q000187:drug effects; D012661:Semen / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D014815:Vitamins / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014815:Vitamins; C422364:inhibin B; D014451:Ubiquinone; D013739:Testosterone; D007265:Inhibins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D002374:Catalase; D013482:Superoxide Dismutase; C024989:coenzyme Q10
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