title: Gender-related differences in the dysfunctional resting networks of migraine suffers.
abstract: BACKGROUND
  Migraine shows gender-specific incidence and has a higher prevalence in females. However, little is known about gender-related differences in dysfunctional brain organization, which may account for gender-specific vulnerability and characteristics of migraine. In this study, we considered gender-related differences in the topological property of resting functional networks.
  
  
  RESULTS
  Data was obtained from 38 migraine patients (18 males and 20 females) and 38 healthy subjects (18 males and 20 females). We used the graph theory analysis, which becomes a powerful tool in investigating complex brain networks on a whole brain scale and could describe functional interactions between brain regions. Using this approach, we compared the brain functional networks between these two groups, and several network properties were investigated, such as small-worldness, network resilience, nodal centrality, and interregional connections. In our findings, these network characters were all disrupted in patients suffering from chronic migraine. More importantly, these functional damages in the migraine-affected brain had a skewed balance between males and females. In female patients, brain functional networks showed worse resilience, more regions exhibited decreased nodal centrality, and more functional connections revealed abnormalities than in male patients.
  
  
  CONCLUSIONS
  These results indicated that migraine may have an additional influence on females and lead to more dysfunctional organization in their resting functional networks.
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.
authors.forename: Jixin
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Jiaofen
authors.initials: J
authors.lastname: Nan
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhao
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.forename: Jinbo
authors.initials: J
authors.lastname: Sun
authors.forename: Dahua
authors.initials: D
authors.lastname: Yu
authors.forename: Minghao
authors.initials: M
authors.lastname: Dong
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Karen M
authors.initials: KM
authors.lastname: von Deneen
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.forename: Fanrong
authors.initials: F
authors.lastname: Liang
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*
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