title: Carvedilol compared with metoprolol on left ventricular ejection fraction after coronary artery bypass graft.
abstract: A number of elective coronary artery bypass graft (CABG) surgery patients have impaired underlying left ventricular function (poor ejection fraction). This study was performed to compare the effect of postoperative oral carvedilol versus metoprolol on left ventricular ejection fraction (LVEF) after CABG compared with metoprolol. In a double-blind clinical trial, 60 patients with coronary artery disease, aged 35 to 65 years, who had an ejection fraction of 15% to 35% were included. Either carvedilol or metoprolol was administered the day after CABG. The patients were evaluated by the same cardiologist 14 days before and 2 and 6 months after elective CABG. The results demonstrated better improvements in LVEF in the carvedilol group. No difference regarding postoperative arrhythmias or mortality was detected. The results suggest that carvedilol may exert more of an improved myocardial effect than metoprolol for the low ejection fraction patients undergoing CABG in the early postoperative months.
authors.affiliation: Department of Cardiac Surgery, Shahid Beheshti University of Medicine, Tehran, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Shahzamani
authors.forename: Arash
authors.initials: A
authors.lastname: Ghanavati
authors.forename: Azam Nouri
authors.initials: AN
authors.lastname: Froutagheh
authors.forename: Mahnoosh
authors.initials: M
authors.lastname: Foroughi
authors.forename: Hosein
authors.initials: H
authors.lastname: Rahimian
authors.forename: Azadeh
authors.initials: A
authors.lastname: Shahsanaei
authors.forename: Seyed Ahmad
authors.initials: SA
authors.lastname: Hasantash
authors.forename: Ali
authors.initials: A
authors.lastname: Dabbagh
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D008790:Metoprolol