title: Screening and identification of potential active components in crude Fructus Corni using solid-phase extraction and LC-LTQ-linear ion trap mass spectrometry.
abstract: BACKGROUND
  Fructus Corni is derived from the dry ripe sarcocarp of Cornus officinalis Sieb. et Zucc. (Cornaceae). It has attracted increasingly much attention as one of the most popular and valuable herbal medicine in clinic. This paper applied a rapid and validated method to the intrinsic quality control of Fructus Corni.
  
  
  METHODS
  The components of crude Fructus Corni were investigated by means of solid-phase extraction (SPE) and LTQ-linear ion trap mass spectrometry (MS) technique in the negative ion mode.
  
  
  RESULTS
  The 29 detected compounds were identified by comparing the retention time and mass spectrometry data and retrieving the reference literatures.
  
  
  CONCLUSIONS
  It was concluded that a rapid and validated method was successfully applied based on SPE-LC-DAD-LTQ-linear-MS(n) which showed high sensitivity and resolution that was more suitable for identifying main components in Traditional Chinese medicines (TCMs) and their prescriptions, which would be helpful to their quality control.
authors.affiliation: Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.forename: Chengrong
authors.initials: C
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Cong
authors.forename: Hao
authors.initials: H
authors.lastname: Cai
authors.forename: Baochang
authors.initials: B
authors.lastname: Cai
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D029768:Cornus / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D011786:Quality Control; D052616:Solid Phase Extraction / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*