title: Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide.
abstract: We report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin-positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug-induced photoleukomelanoderma.
authors.affiliation: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Masuoka
authors.forename: Toshinori
authors.initials: T
authors.lastname: Bito
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Chikako
authors.initials: C
authors.lastname: Nishigori
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D044466:Asian People; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D000305:Adrenal Cortex Hormones; D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents; D006852:Hydrochlorothiazide; D016559:Tacrolimus