title: Angiogenic and antiangiogenic factors before and after resolution of maternal mirror syndrome.
abstract: Mirror syndrome is a rare condition that involves fetal hydrops, placentomegaly and severe maternal edema. The pathogenesis of this syndrome mimics endothelial dysfunction observed in pre-eclampsia. We report a case of maternal mirror syndrome caused by bilateral fetal hydrothorax that resolved after intrauterine pleuroamniotic shunt placement. At the time of the clinical manifestation there was an antiangiogenic state similar to that seen in pre-eclampsia, which resolved after fetal treatment. Our findings suggest that mirror syndrome is a manifestation of a broad spectrum of pathological conditions that induces an antiangiogenic state.
authors.affiliation: Obstetrics Department, Fetal Medicine Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. ellurba@vhebron.net
authors.forename: E
authors.initials: E
authors.lastname: Llurba
authors.forename: G
authors.initials: G
authors.lastname: Marsal
authors.forename: O
authors.initials: O
authors.lastname: Sanchez
authors.forename: C
authors.initials: C
authors.lastname: Dominguez
authors.forename: J
authors.initials: J
authors.lastname: Alijotas-Reig
authors.forename: E
authors.initials: E
authors.lastname: Carreras
authors.forename: L
authors.initials: L
authors.lastname: Cabero
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood; D002585:Cesarean Section; D003937:Diagnosis, Differential; D000071063:Endoglin; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006876:Hydrothorax / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D008565:Membrane Proteins / Q000097:blood; D018919:Neovascularization, Physiologic; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood; D013577:Syndrome; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D008565:Membrane Proteins; C098069:PIGF protein, human; D011956:Receptors, Cell Surface; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1