title: Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa.
abstract: Probiotic bacteria can modulate immune responses in the host gastrointestinal tract to promote health. The genomics era has provided novel opportunities for the discovery and characterization of bacterial probiotic effector molecules that elicit specific responses in the intestinal system. Furthermore, nutrigenomic analyses of the response to probiotics have unravelled the signalling and immune response pathways which are modulated by probiotic bacteria. Together, these genomic approaches and nutrigenomic analyses have identified several bacterial factors that are involved in modulation of the immune system and the mucosal barrier, and have revealed that a molecular 'bandwidth of human health' could represent a key determinant in an individual's physiological responsiveness to probiotics. These approaches may lead to improved stratification of consumers and to subpopulation-level probiotic supplementation to maintain or improve health, or to reduce the risk of disease.
authors.affiliation: Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Bron
authors.forename: Peter
authors.initials: P
authors.lastname: van Baarlen
authors.forename: Michiel
authors.initials: M
authors.lastname: Kleerebezem
mesh_terms: D001419:Bacteria / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology*; D019936:Probiotics / Q000378:metabolism*
chemical_list: D007155:Immunologic Factors
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