title: Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case-control studies.
abstract: The C3435T (Ile1142Ile) polymorphism of the multidrug resistance gene (MDR1) has been implicated in leukemia risk, but the reported results are inconsistent. Here we performed a meta-analysis to evaluate the association between C3435T polymorphism and the risk of leukemia using all case-control studies published before June 2011 according to PubMed. A total of 10 case-control studies were included in this analysis. We found that variant genotypes of C3435T (CT/TT) were significantly associated with an increased risk of leukemia (CT/TT vs. CC: odds ratio [OR] = 1.29; 95% confidence interval [CI] = 1.11-1.50, p = 0.284 for heterogeneity test). Additionally, the association was more significant in chronic leukemia (specifically B-cell chronic lymphocytic leukemia [B-CLL]) (OR = 1.94; 95% CI = 1.32-2.85, p = 0.648 for heterogeneity test) than in acute leukemia (OR = 1.19; 95% CI = 1.01-1.40, p = 0.616 for heterogeneity test), p = 0.021 for heterogeneity test between groups. These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia.
authors.affiliation: Department of Hematology, Nanjing Medical University, Wuxi, Jiangsu Province, China.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Qian
authors.forename: Songyu
authors.initials: S
authors.lastname: Cao
authors.forename: Guohua
authors.initials: G
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Shen
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1