title: Expression of paxillin and FAK mRNA and the related clinical significance             in esophageal carcinoma.
abstract: The objective of the present study was to investigate the expression of             paxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues,             and their relationship with clinicopathological parameters, as well as to analyze             the correlation of paxillin and FAK mRNA levels in esophageal carcinoma. By using             reverse transcription polymerase chain reaction (RT-PCR), the mRNA expression             levels of paxillin and FAK were detected in 121 samples of esophageal carcinoma,             43 samples of atypical hyperplasia and 56 samples of normal esophageal mucosa.             The results showed that the positive rates of paxillin and FAK mRNA expression             in esophageal carcinoma were 87.6 and 80.17%, respectively, which were significantly             higher (P<0.05) than those in atypical hyperplasia (44.19 and 39.53%) and normal             esophageal mucosa (5.36 and 12.5%). Notably, paxillin and FAK mRNA expression             levels were significantly correlated with the differentiation degree and depth             of invasion of esophageal carcinoma and with lymph node metastasis (P<0.05).             In addition, paxillin and FAK mRNA expression levels in esophageal carcinoma were             positively correlated (r=0.4804, P=0.000). In conclusion, the combined detection             of paxillin and FAK mRNA expression is expected to provide a theoretical basis             for the molecular diagnosis of esophageal carcinoma.
authors.affiliation: Yancheng Health Vocational and Technical College, Yancheng 224006, PR China. yccaihx1962@126.com
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Cai
authors.forename: Liu-Cai
authors.initials: LC
authors.lastname: Yang
authors.forename: Xiang-He
authors.initials: XH
authors.lastname: Song
authors.forename: Zhou-Ru
authors.initials: ZR
authors.lastname: Liu
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Chen
authors.forename: Guo-Kai
authors.initials: GK
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D051419:Paxillin / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D051419:Paxillin; D012333:RNA, Messenger; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human