title: MicroRNA regulation in cancer-associated fibroblasts.
abstract: The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bldg.37, Rm. 4054, 9000 Rockville Pike, Bethesda, MD, 20892, USA. apreliko@mail.nih.gov.
authors.forename: Olga
authors.initials: O
authors.lastname: Aprelikova
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bldg.37, Rm. 4054, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Green
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D019139:Tumor Escape
chemical_list: D035683:MicroRNAs
references.citation: Cell. 2001 Dec 28;107(7):823-6
references.pmid: 11779458
references.citation: Hepatology. 2008 Mar;47(3):897-907
references.pmid: 18176954
references.citation: Science. 2004 Feb 6;303(5659):848-51
references.pmid: 14764882
references.citation: Cancer Res. 2008 Aug 1;68(15):6241-50
references.pmid: 18676848
references.citation: Panminerva Med. 1997 Sep;39(3):174-7
references.pmid: 9360417
references.citation: Nature. 1996 Jan 4;379(6560):88-91
references.pmid: 8538748
references.citation: Clin Chem. 2010 Jul;56(7):1107-18
references.pmid: 20431052
references.citation: Genes Dev. 2003 Dec 15;17(24):3048-61
references.pmid: 14701874
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
references.pmid: 16885212
references.citation: Nat Genet. 2008 May;40(5):650-5
references.pmid: 18408720
references.citation: Nat Rev Cancer. 2007 Nov;7(11):834-46
references.pmid: 17957189
references.citation: Cell. 2005 Dec 16;123(6):1001-11
references.pmid: 16360031
references.citation: Genes Dev. 2009 Sep 15;23(18):2152-65
references.pmid: 19759263
references.citation: Arch Pathol Lab Med. 2002 Jul;126(7):829-36
references.pmid: 12088453
references.citation: Lung Cancer. 2004 Aug;45 Suppl 2:S163-75
references.pmid: 15552797
references.citation: Annu Rev Pathol. 2006;1:119-50
references.pmid: 18039110
references.citation: Oral Oncol. 2008 May;44(5):509-17
references.pmid: 17826300
references.citation: Cell. 2005 May 6;121(3):335-48
references.pmid: 15882617
references.citation: Cancer Res. 2004 Dec 1;64(23):8492-5
references.pmid: 15574751
references.citation: Cancer Cell. 2010 Feb 17;17(2):135-47
references.pmid: 20138012
references.citation: Cell Cycle. 2010 Nov 1;9(21):4387-98
references.pmid: 20980827
references.citation: Nat Genet. 2005 Aug;37(8):899-905
references.pmid: 16007089
references.citation: Clin Sci (Lond). 2011 Aug;121(4):141-58
references.pmid: 21526983
references.citation: J Cell Biochem. 2007 Jul 1;101(4):830-9
references.pmid: 17211838
references.citation: Int J Cancer. 2004 Nov 1;112(2):213-8
references.pmid: 15352032
references.citation: Semin Cell Dev Biol. 2010 Feb;21(1):19-25
references.pmid: 19857592
references.citation: Cancer Res. 2006 Jan 1;66(1):29-33
references.pmid: 16397211
references.citation: Adv Cancer Res. 2008;100:159-202
references.pmid: 18620096
references.citation: Cancer Cell. 2004 Jul;6(1):17-32
references.pmid: 15261139
references.citation: Nat Rev Cancer. 2006 May;6(5):392-401
references.pmid: 16572188
references.citation: Trends Genet. 2009 Jan;25(1):30-8
references.pmid: 19054589
references.citation: J Biol Chem. 2010 Jun 4;285(23):17442-52
references.pmid: 20353945
references.citation: J Immunol. 2010 Dec 15;185(12):7244-51
references.pmid: 21068402
references.citation: J Clin Invest. 2007 Nov;117(11):3155-63
references.pmid: 17975657
references.citation: Nature. 2009 Oct 22;461(7267):1084-91
references.pmid: 19847259
references.citation: Cancer Res. 1999 Oct 1;59(19):5002-11
references.pmid: 10519415
references.citation: Commun Integr Biol. 2010 Sep;3(5):447-50
references.pmid: 21057637
references.citation: Cancer Res. 2000 May 1;60(9):2562-6
references.pmid: 10811140
references.citation: Cancer Biol Ther. 2008 Jun;7(6):882-8
references.pmid: 18344687
references.citation: Oncogene. 2011 Oct 13;30(41):4231-42
references.pmid: 21532615
references.citation: Nature. 2007 Oct 4;449(7162):557-63
references.pmid: 17914389
references.citation: Cancer Cell. 2002 May;1(4):339-53
references.pmid: 12086849
references.citation: Nat Genet. 2002 Nov;32(3):355-7
references.pmid: 12379854
references.citation: Cancer Res. 2004 Oct 15;64(20):7231-6
references.pmid: 15492239
references.citation: PLoS Med. 2008 Jan 29;5(1):e19
references.pmid: 18232728
references.citation: Cancer Res. 2010 Jul 15;70(14):5706-16
references.pmid: 20570886
references.citation: Mol Cell. 2010 Aug 27;39(4):493-506
references.pmid: 20797623
references.citation: Int J Dev Biol. 2004;48(5-6):509-17
references.pmid: 15349825
references.citation: Eur J Immunol. 2009 Jun;39(6):1608-18
references.pmid: 19408243
references.citation: Cytokine. 2008 Aug;43(2):194-9
references.pmid: 18572414
references.citation: Biochem Biophys Res Commun. 2003 Sep 12;309(1):232-40
references.pmid: 12943687
references.citation: Cell. 2009 Jun 12;137(6):1032-46
references.pmid: 19524507
references.citation: Cancer Biol Ther. 2006 Dec;5(12):1640-6
references.pmid: 17106243
references.citation: Mol Carcinog. 2004 Jun;40(2):116-21
references.pmid: 15170816
references.citation: Nat Rev Cancer. 2001 Oct;1(1):46-54
references.pmid: 11900251
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13556-61
references.pmid: 18768788
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: J Pathol. 2003 Jul;200(4):429-47
references.pmid: 12845611
references.citation: Cancer Res. 2008 Dec 1;68(23):9900-8
references.pmid: 19047171