title: Anacetrapib: a new weapon against dyslipidemia.
abstract: Anacetrapib is a cholesteryl-ester-transfer-protein (CETP) inhibitor, a new class of experimental drugs in the treatment of primary hypercholesterolemia and dyslipidaemia associated with the metabolic syndrome. One of the major advantages of this agent is, apart from the significant decrease in LDL-C it produces a substantial increase in HDL-C. Phase I, II, and III clinical trials have shown that anacetrapib is safe alone or in combination with statins. However, longterm clinical trials are required in order to assess whether it reduces mortality in individuals at high-risk of cardiovascular disease.
authors.affiliation: Nephrology Department, General Hospital of Rhodes, Agioi Apostoloi, Greece. gaperis@yahoo.com
authors.forename: Georgios
authors.initials: G
authors.lastname: Aperis
authors.forename: Christos
authors.initials: C
authors.lastname: Paliouras
authors.forename: Eirini
authors.initials: E
authors.lastname: Tsampikaki
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papakonstantinou
authors.forename: Polichronis
authors.initials: P
authors.lastname: Alivanis
mesh_terms: D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000473:pathology; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000473:pathology; D023303:Oxazolidinones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D023303:Oxazolidinones; C530884:anacetrapib