title: Physiology of potassium channels in the inner membrane of mitochondria.
abstract: The inner membrane of the ATP-producing organelles of endosymbiotic origin, mitochondria, has long been considered to be poorly permeable to cations and anions, since the strict control of inner mitochondrial membrane permeability is crucial for efficient ATP synthesis. Over the past 30 years, however, it has become clear that various ion channels--along with antiporters and uniporters--are present in the mitochondrial inner membrane, although at rather low abundance. These channels are important for energy supply, and some are a decisive factor in determining whether a cell lives or dies. Their electrophysiological and pharmacological characterisations have contributed importantly to the ongoing elucidation of their pathophysiological roles. This review gives an overview of recent advances in our understanding of the functions of the mitochondrial potassium channels identified so far. Open issues concerning the possible molecular entities giving rise to the observed activities and channel protein targeting to mitochondria are also discussed.
authors.affiliation: Department of Biology, University of Padova, Padova, Italy. ildiko.szabo@unipd.it
authors.forename: Ildikò
authors.initials: I
authors.lastname: Szabò
authors.forename: Luigi
authors.initials: L
authors.lastname: Leanza
authors.forename: Erich
authors.initials: E
authors.lastname: Gulbins
authors.forename: Mario
authors.initials: M
authors.lastname: Zoratti
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D051336:Mitochondrial Membranes / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000502:physiology*
chemical_list: D015221:Potassium Channels; D000255:Adenosine Triphosphate; D011188:Potassium
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