title: [Genomic imprinting and carcinogenesis].
abstract: Genomic imprinting is an epigenetic marking and a stable transmission of monoallelic gene expression patterns in a parent of- origin-specific manner. Aberrant imprinting has been linked to a number of human genetic disorders, including congenital abnormalities, childhood cancer, behavior disorders, and cancer in adults. Imprinted genes play roles in carcinogenesis. Recently, progress in researched on epigenetic mechanisms of imprinted genes, in edition to analysis of the pathology of the oncogenetic mechanisms, has begun to be clinically applied to diagnostic methods, prevention, and cancer drug development.
authors.affiliation: Dept. of Informative Genetics, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Arima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hiura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okae
authors.forename: Naoko
authors.initials: N
authors.lastname: Miyauchi
authors.forename: Fumi
authors.initials: F
authors.lastname: Satou
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D018392:Genomic Imprinting; D006801:Humans; D015398:Signal Transduction