title: Factors associated with brachial-ankle pulse wave velocity in the general population.
abstract: The present study investigated factors that modify or affect arterial stiffness as assessed by brachial-ankle pulse wave velocity (baPWV) in the general population. Subjects had previously participated in a physical checkup program (n=911), and baPWV and urinary albumin and sodium excretion were also measured. Urine albumin was expressed as the ratio of urine albumin to urine creatinine. Individual salt intake was assessed by estimating 24-h urinary salt excretion and expressed as the ratio of estimated salt intake to body weight. The mean blood pressure and baPWV were 127.1±15.2/77.0±9.5 mm Hg and 15.9±3.3 m s(-1), respectively. Univariate analysis demonstrated that baPWV correlated with various factors including age, blood pressure, electrocardiogram voltage (SV(1)+RV(5)), urine albumin and salt intake. Multivariate regression analysis revealed that electrocardiogram voltage (P<0.001), systolic blood pressure (P<0.0001), urine albumin (P<0.001) and salt intake (P<0.001), independently correlated with baPWV after adjustment for other possible factors. Similar results were obtained for participants not taking any medication. These results suggest that the baPWV value is independently associated with individual salt intake and cardiac and renal damage, and could be a useful procedure for identifying individuals with concealed risk of cardiovascular disease.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sonoda
authors.forename: H
authors.initials: H
authors.lastname: Takase
authors.forename: Y
authors.initials: Y
authors.lastname: Dohi
authors.forename: G
authors.initials: G
authors.lastname: Kimura
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000419:Albuminuria / Q000652:urine; D055109:Ankle Brachial Index; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D017673:Sodium Chloride, Dietary; D016909:Tibial Arteries / Q000502:physiology*
chemical_list: D017673:Sodium Chloride, Dietary; D012964:Sodium; D003404:Creatinine