title: Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I.
abstract: OBJECTIVE
  High levels of soluble receptor for advanced glycation end products (sRAGE) have been shown to have an atheroprotective role; however, no data are available on this molecule in acute coronary syndromes (ACS). We evaluated sRAGE levels in patients with non-ST segment elevation ACS (NSTE-ACS) or with chronic stable angina.
  
  
  METHODS
  We studied 265 patients, 190 of whom had NSTE-ACS and 75 had chronic stable angina.
  
  
  RESULTS
  Plasma sRAGE values were comparable in the two groups (P=0.19). However, in the patients with NSTE-ACS, sRAGE levels were significantly higher in patients with cardiac troponin-I (cTnI) of more than or equal to 0.04 µg/l compared with those with cTnI of less than 0.04 µg/l [758 (493-1536 ) pg/ml vs. 454 (167-899) pg/ml; P=0.0037]. A significant correlation (r=0.323, P=0.0045) was found between sRAGE and cTnI levels in patients with NSTE-ACS.
  
  
  CONCLUSIONS
  Plasma sRAGE levels are elevated in patients with NSTE-ACS with positive cTnI, suggesting that they could be related to myocardial cell damage.
authors.affiliation: CNR Institute of Clinical Physiology, Pisa, Italy. lapina@ifc.cnr.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Basta
authors.forename: Serena
authors.initials: S
authors.lastname: Del Turco
authors.forename: Federica
authors.initials: F
authors.lastname: Marchi
authors.forename: Teresa
authors.initials: T
authors.lastname: Navarra
authors.forename: Debora
authors.initials: D
authors.lastname: Battaglia
authors.forename: Antonella
authors.initials: A
authors.lastname: Mercuri
authors.forename: Annamaria
authors.initials: A
authors.lastname: Mazzone
authors.forename: Sergio
authors.initials: S
authors.lastname: Berti
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D000368:Aged; D060050:Angina, Stable / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D019210:Troponin I / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D019210:Troponin I