title: CD133 expression associated with poor prognosis in ovarian cancer.
abstract: As a putative marker for cancer stem cells in human malignant tumors, including ovarian cancer, CD133 expression may define a tumor-initiating subpopulation of cells and is associated with the clinical outcome of patients. However, at this time its clinical significance in ovarian cancer remains uncertain. The aim of this study was to clarify the clinical role of CD133 expression in human ovarian cancer. Immunohistochemical staining of CD133 expression was performed in 400 ovarian carcinoma samples using tissue microarray. The associations among CD133 expression and clinical factors (diagnosis, tumor grade, cancer stage, and clinical response to chemotherapy), overall survival and disease-free survival time were analyzed. CD133 expression was found in 31% of ovarian carcinoma samples. Fisher's exact test and one-way analysis of variance suggested that CD133 expression was associated with high-grade serous carcinoma (P=0.035), late-stage disease (P<0.001), ascites level (P=0.010), and non-response to chemotherapy (P=0.023). CD133 expression was also associated with shorter overall survival time (P=0.007) and shorter disease-free survival time (P<0.001) by log-rank test. Moreover, CD133 expression was an independent predictor of shorter disease-free survival time in an unconditional logistic regression analysis with multiple covariates (P=0.024). Our results thus show that CD133 expression is a predictor of poor clinical outcome for patients with ovarian cancer, supporting the proposed link between CD133 and cancer stem cells.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Guo
authors.forename: Doo Young
authors.initials: DY
authors.lastname: Chang
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Rosen
authors.forename: Imelda
authors.initials: I
authors.lastname: Mercado-Uribe
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
mesh_terms: D000071916:AC133 Antigen; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003131:Combined Modality Therapy; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D010455:Peptides / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides
references.citation: Int J Oncol. 2009 Mar;34(3):717-27
references.pmid: 19212677
references.citation: Gastroenterology. 2007 Jun;132(7):2542-56
references.pmid: 17570225
references.citation: Saudi Med J. 2010 Sep;31(9):980-6
references.pmid: 20844808
references.citation: Blood. 1997 Dec 15;90(12):5002-12
references.pmid: 9389720
references.citation: J Cell Physiol. 2009 May;219(2):301-13
references.pmid: 19160414
references.citation: J Pathol. 2009 Dec;219(4):427-34
references.pmid: 19621338
references.citation: Pathology. 1979 Jul;11(3):493-532
references.pmid: 230444
references.citation: Cancer Biol Ther. 2007 May;6(5):763-8
references.pmid: 17592251
references.citation: J Biochem Mol Toxicol. 2003;17(1):7-23
references.pmid: 12616643
references.citation: Pathology. 1979 Apr;11(2):251-82
references.pmid: 460950
references.citation: Oncologist. 2002;7 Suppl 5:20-8
references.pmid: 12324630
references.citation: J Clin Oncol. 1997 Jan;15(1):172-6
references.pmid: 8996139
references.citation: Oncogene. 2008 Nov 6;27(52):6646-56
references.pmid: 18663354
references.citation: Am J Surg Pathol. 2004 Apr;28(4):496-504
references.pmid: 15087669
references.citation: Cancer Biol Ther. 2007 Sep;6(9):1490-5
references.pmid: 17881904
references.citation: Oncol Rep. 2011 Jan;25(1):141-6
references.pmid: 21109969
references.citation: Clin Cancer Res. 2008 Jan 1;14(1):123-9
references.pmid: 18172261
references.citation: Stem Cells. 2009 Dec;27(12):2875-83
references.pmid: 19816957
references.citation: Acta Biochim Biophys Sin (Shanghai). 2010 Sep;42(9):593-602
references.pmid: 20705681
references.citation: Oncol Rep. 2010 Aug;24(2):537-46
references.pmid: 20596644
references.citation: J Clin Oncol. 2008 Nov 10;26(32):5284-93
references.pmid: 18854563
references.citation: Pathology. 1979 Jan;11(1):5-26
references.pmid: 431978
references.citation: Blood. 1997 Dec 15;90(12):5013-21
references.pmid: 9389721
references.citation: Mod Pathol. 2010 Mar;23(3):376-80
references.pmid: 20062010
references.citation: Biochem Biophys Res Commun. 2007 Apr 20;355(4):855-9
references.pmid: 17307142
references.citation: Natl Cancer Inst Monogr. 1975 Oct;42:5-7
references.pmid: 1234636
references.citation: J Transl Med. 2009 Jul 07;7:56
references.pmid: 19583834
references.citation: Clin Cancer Res. 2010 Jun 15;16(12):3113-20
references.pmid: 20530701
references.citation: Cancer. 2006 May 1;106(9):1925-32
references.pmid: 16568440
references.citation: Cell Death Differ. 2008 Mar;15(3):504-14
references.pmid: 18049477
references.citation: Int J Gynecol Cancer. 2008 May-Jun;18(3):506-14
references.pmid: 17868344
references.citation: Ann Oncol. 1996 Apr;7(4):361-4
references.pmid: 8805927
references.citation: Cancer Sci. 2010 Apr;101(4):906-12
references.pmid: 20219069
references.citation: Front Biosci (Landmark Ed). 2011 Jan 01;16:368-92
references.pmid: 21196176
references.citation: Cancer. 2011 Jan 1;117(1):162-74
references.pmid: 20806346
references.citation: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references.pmid: 20610543
references.citation: Int J Gynecol Pathol. 2008 Jan;27(1):1-9
references.pmid: 18156967
references.citation: Nature. 2001 Nov 1;414(6859):105-11
references.pmid: 11689955
references.citation: Int J Clin Pract. 2008 Aug;62(8):1212-8
references.pmid: 18479363
references.citation: Breast Cancer Res. 2008;10(1):R10
references.pmid: 18241344
references.citation: Oncogene. 2009 Jan 15;28(2):209-18
references.pmid: 18836486
references.citation: Cancer Sci. 2011 May;102(5):1107-11
references.pmid: 21276138
references.citation: Br J Obstet Gynaecol. 1989 Aug;96(8):889-92
references.pmid: 2775686
references.citation: BMC Cancer. 2009 Jul 07;9:221
references.pmid: 19583859
references.citation: Genome Biol. 2008;9(5):R83
references.pmid: 18492237
references.citation: Br J Cancer. 2010 Apr 13;102(8):1276-83
references.pmid: 20354527
references.citation: Mod Pathol. 2009 Jun;22(6):817-23
references.pmid: 19329942