title: Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines.
abstract: A conceptually new three-component reaction was developed to construct a six-membered fused N-heterocyclic ring affording (pyrazolo)pyrimidines/pyridines as potential inhibitors of PDE4. The reaction is catalyzed by triflic acid in acetic acid in the presence of aerial oxygen.
authors.affiliation: Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India.
authors.forename: P Mahesh
authors.initials: PM
authors.lastname: Kumar
authors.forename: K Siva
authors.initials: KS
authors.lastname: Kumar
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Mohakhud
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: R
authors.initials: R
authors.lastname: Kapavarapu
authors.forename: Kishore V L
authors.initials: KV
authors.lastname: Parsa
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D003198:Computer Simulation; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000737:chemistry* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D011720:Pyrazoles / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D006571:Heterocyclic Compounds; D008698:Mesylates; D058988:Phosphodiesterase 4 Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C012077:trifluoromethanesulfonic acid; C030986:pyrimidine; C023666:pyridine; D010100:Oxygen