title: In vivo monitoring of organ-selective distribution of CdHgTe/SiO2 nanoparticles in mouse model.
abstract: CdHgTe/SiO(2) nanoparticles were prepared by SiO(2) capping on the surface of CdHgTe QDs. The characteristics, such as optical spectra, photostability, size and cell toxicity were investigated. The dynamic distribution of CdHgTe/SiO(2) nanoparticles was in vivo monitored by near infrared fluorescence imaging system. CdHgTe/SiO(2) nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 785 nm and high photo-stability. The hydrodynamic diameter of CdHgTe/SiO(2) nanoparticles could be adjusted to 122.3 nm. Compared to CdHgTe QDs, inhibitory effects of CdHgTe/SiO(2) nanoparticles on proliferation of HCT116 cells decreased to a certain extent. CdHgTe/SiO(2) nanoparticles had their specific dynamic distribution behavior, which provided new perspectives for bio-distribution of nanoparticles.
authors.affiliation: Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Gulou District, Nanjing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Sisi
authors.initials: S
authors.lastname: Cui
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Tu
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Gu
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019187:Cadmium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D017669:Mercury Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D017669:Mercury Compounds; C104191:mercury cadmium telluride; D012822:Silicon Dioxide
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