title: Dissimilar effects of tolterodine on detrusor overactivity in awake rats with chemical cystitis and partial bladder outlet obstruction.
abstract: OBJECTIVE
  We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the NVCs in these models.
  
  
  METHODS
  A total of 20 female Sprague-Dawley rats were used in this study. In eight rats, chemical cystitis was induced by intravesical instillation of HCl. Twelve rats were subjected to sham instillations or partial BOO. Four weeks after intravesical instillation or 2 weeks after partial BOO, cystometrograms were obtained by use of simultaneous recording of intravesical and intraabdominal pressure in all unanesthetized, unrestrained rats in metabolic cages.
  
  
  RESULTS
  A total of 17 rats survived. In the rats with acute injury by HCl, 50% showed detrusor overactivity (DO), which was not seen in the sham group. The cystitis group had lower DO pressure without a difference in DO frequency compared with the BOO group. After the administration of tolterodine, the cystitis group showed no difference in DO frequency or pressure, whereas the BOO group showed decreased values for both parameters.
  
  
  CONCLUSIONS
  Our study showed that toleterodine produced no effect on DO during the filling phase in rats with chronic chemical cystitisbut decreased the frequency and pressure of DO in rats with BOO. Clinically, studies are needed to improve the treatment effect of anticholinergic drugs ininterstitial cystitis patients with overactive bladder.
authors.affiliation: Department of Urology, Inha University College of Medicine, Incheon, Korea.
authors.forename: Long-Hu
authors.initials: LH
authors.lastname: Jin
authors.forename: Chang-Shin
authors.initials: CS
authors.lastname: Park
authors.forename: Hwa-Yeon
authors.initials: HY
authors.lastname: Shin
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Yoon
authors.forename: Tack
authors.initials: T
authors.lastname: Lee
references.citation: Eur Urol. 2003 Jan;43(1):1-5
references.pmid: 12507537
references.citation: Int Urol Nephrol. 2007;39(2):489-95
references.pmid: 17431811
references.citation: Rev Urol. 2002;4 Suppl 1:S9-S15
references.pmid: 16986036
references.citation: Curr Opin Urol. 2010 Jan;20(1):43-8
references.pmid: 19875964
references.citation: Int Neurourol J. 2010 Apr;14(1):54-60
references.pmid: 21120177
references.citation: Neurourol Urodyn. 2008;27(1):88-95
references.pmid: 17565725
references.citation: Urology. 1997 May;49(5A Suppl):76-80
references.pmid: 9146005
references.citation: Urology. 2005 Oct;66(4):702-6
references.pmid: 16230120
references.citation: Rev Urol. 2002;4 Suppl 1:S3-8
references.pmid: 16986032
references.citation: BJU Int. 2008 Jan;101(1):45-51
references.pmid: 17868419
references.citation: Urol Res. 1991;19(2):117-21
references.pmid: 1712996
references.citation: J Urol. 1988 Jul;140(1):203-6
references.pmid: 3379688
references.citation: J Urol. 2001 Sep;166(3):1111-8
references.pmid: 11490308
references.citation: J Urol. 1987 Dec;138(6):1461-6
references.pmid: 3682077
references.citation: Am Fam Physician. 2001 Oct 1;64(7):1199-206
references.pmid: 11601802
references.citation: J Urol. 2000 Aug;164(2):423-7
references.pmid: 10893601
references.citation: Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003193
references.pmid: 17054163
references.citation: J Womens Health (Larchmt). 2009 Sep;18(9):1361-8
references.pmid: 19743907
references.citation: Pain. 1993 Mar;52(3):259-285
references.pmid: 7681556
references.citation: J Urol. 1997 May;157(5):1937-40
references.pmid: 9112567
references.citation: Urol Clin North Am. 1994 Feb;21(1):41-53
references.pmid: 8284844
references.citation: Neurourol Urodyn. 2002;21(2):167-78
references.pmid: 11857671
references.citation: J Neurosci. 1999 Jun 1;19(11):4644-53
references.pmid: 10341262
references.citation: J Urol. 1986 Aug;136(2):501-4
references.pmid: 3735523
references.citation: J Urol. 2008 May;179(5):1857-61; discussion 1861-2
references.pmid: 18353390
references.citation: Urology. 2003 Nov;62(5 Suppl 2):28-37; discussion 40-2
references.pmid: 14662404