title: Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia.
abstract: DCL following hematopoietic stem cell transplantation has been reported in approximately 5% of all leukemic relapses. There have been several reports on DCL, mainly AML after umbilical cord blood transplantation. In this case study, we present a young boy diagnosed with Fanconi anemia who underwent an umbilical cord blood transplantation. Because of the graft failure, he was retransplanted one month later, also with a cord blood transplant. Two years after the second transplant, he developed AML, where 100% of the cells were of female donor origin. The donor, a now 14-yr-old female, was recently reported healthy.
authors.affiliation: Astrid Lindgren Children's Hospital, Karolinska University Hospital-Huddinge, Sweden. britt.gustafsson@ki.se
authors.forename: Britt
authors.initials: B
authors.lastname: Gustafsson
authors.forename: Jacob
authors.initials: J
authors.lastname: Moell
authors.forename: Katarina
authors.initials: K
authors.lastname: Leblanc
authors.forename: Gisela
authors.initials: G
authors.lastname: Barbany
authors.forename: Stefan
authors.initials: S
authors.lastname: Söderhäll
authors.forename: Jacek
authors.initials: J
authors.lastname: Winiarski
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D005199:Fanconi Anemia / Q000150:complications* / Q000628:therapy*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014184:Transplantation, Homologous / Q000009:adverse effects*; D016896:Treatment Outcome