title: Multiple applications of flurbiprofen and chlorhexidine chips in patients with chronic periodontitis: a randomized, double blind, parallel, 2-arms clinical trial.
abstract: OBJECTIVE
  The aim of the present randomized, double blind, parallel, 2-arm clinical study was to examine the safety and efficacy of frequent applications of chlorhexidine chip (CHX) and flurbiprofen chip (FBP) in patients with chronic periodontitis.
  
  
  METHODS
  Sixty patients were randomized into CHX and FBP groups. Following OHI and scaling and root planing (SRP), baseline pocket depth (PD) measurements, gingival recession and bleeding on probing (BOP) were performed and repeated at week 4 and 8. The assigned chip was placed at weeks 0, 1, 2, 3, 5, 7.
  
  
  RESULTS
  Mean PD reduction in the CHX group was 2.08 mm (7.17 to 5.09, p < 0.0001). Mean PD reduction in the FBP group was 2.27 mm (6.72 to 4.45, p < 0.0001). Ninety-seven percentage and 95% of these sites exhibited PD reduction ≥1 mm, while 38% and 34% of the sites exhibited PD ≥3 mm (FBP and CHX, respectively). Clinical attachment level gain (1.66 and 1.95 mm, respectively) was statistically significant (p < 0.0001). Baseline BOP dropped from 98% and 100% to 24% and 30% for the CHX and FBP groups, respectively (p < 0.0001).
  
  
  CONCLUSIONS
  Frequent applications of CHX and FBP chips resulted in a significant improvement in the periodontal condition in these sites. Furthermore studies will be required to compare this new treatment regimen to SRP or SRP with single chip application.
authors.affiliation: Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus and the Faculty of Medicine - Technion (I.I.T.), Haifa, Israel. machtei@rambam.health.gov.il
authors.forename: Eli E
authors.initials: EE
authors.lastname: Machtei
authors.forename: Ilan
authors.initials: I
authors.lastname: Hirsh
authors.forename: Maher
authors.initials: M
authors.lastname: Falah
authors.forename: Eyal
authors.initials: E
authors.lastname: Shoshani
authors.forename: Avi
authors.initials: A
authors.lastname: Avramoff
authors.forename: Adel
authors.initials: A
authors.lastname: Penhasi
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D016014:Linear Models; D008297:Male
chemical_list: D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D005480:Flurbiprofen; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
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