title: Ultrastructural characterization of pandemic (H1N1) 2009 virus.
abstract: We evaluated pandemic influenza A (H1N1) 2009 virus isolates and respiratory tissues collected at autopsy by electron microscopy. Many morphologic characteristics were similar to those previously described for influenza virus. One of the distinctive features was dense tubular structures in the nuclei of infected cells.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cgoldsmith@cdc.gov
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Goldsmith
authors.forename: Maureen G
authors.initials: MG
authors.lastname: Metcalfe
authors.forename: Dominique C
authors.initials: DC
authors.lastname: Rollin
authors.forename: Wun-Ju
authors.initials: WJ
authors.lastname: Shieh
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Paddock
authors.forename: Xiyan
authors.initials: X
authors.lastname: Xu
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
mesh_terms: D000818:Animals; D001706:Biopsy; D002460:Cell Line; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification / Q000648:ultrastructure*; D008168:Lung / Q000473:pathology / Q000821:virology; D014771:Virion / Q000648:ultrastructure
references.citation: Cell. 1991 Oct 4;67(1):117-30
references.pmid: 1913813
references.citation: Jpn J Infect Dis. 2010 Jan;63(1):67-71
references.pmid: 20093768
references.citation: Science. 2009 Jul 10;325(5937):197-201
references.pmid: 19465683
references.citation: Nature. 2006 Jan 26;439(7075):490-2
references.pmid: 16437116
references.citation: J Gen Virol. 2003 Mar;84(Pt 3):517-527
references.pmid: 12604801
references.citation: Proc Natl Acad Sci U S A. 1998 May 12;95(10):5746-51
references.pmid: 9576955
references.citation: Nature. 2009 Jun 18;459(7249):931-9
references.pmid: 19525932
references.citation: N Engl J Med. 2009 Jun 18;360(25):2605-15
references.pmid: 19423869
references.citation: EMBO J. 1998 Jan 2;17(1):288-96
references.pmid: 9427762
references.citation: J Exp Med. 1960 Nov 1;112:945-52
references.pmid: 13693270
references.citation: J Clin Virol. 2008 Dec;43(4):381-90
references.pmid: 18926763
references.citation: Am J Pathol. 2010 Jul;177(1):166-75
references.pmid: 20508031
references.citation: Virus Res. 2003 Mar;92(1):89-98
references.pmid: 12606080
references.citation: Virology. 1968 Dec;36(4):681-3
references.pmid: 5723676