title: Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab.
abstract: We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude that the indications for tumor necrosis factor (TNF) inhibitors should be strictly decided and that a nationwide cohort study is necessary to assess the risk of cancer in patients with JIA exposed to biologics.
authors.affiliation: Department of Pediatrics, Hokkaido University School of Medicine, North-15 West-7, Kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Takezaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okura
authors.forename: Mizuho
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
authors.forename: Junjiro
authors.initials: J
authors.lastname: Ohshima
authors.forename: Makoto
authors.initials: M
authors.lastname: Kaneda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Cho
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yamada
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Iguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D003131:Combined Modality Therapy; D057915:Drug Substitution; D018237:Germinoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D005938:Glucocorticoids; D011239:Prednisolone; D000069285:Infliximab