title: Post-genomics of Neisseria meningitidis: an update.
abstract: Neisseria meningitidis infection still remains a major life-threatening bacterial disease worldwide. The availability of bacterial genomic sequences generated a paradigm shift in microbiological and vaccines sciences, and post-genomics (comparative genomics, functional genomics, proteomics and a combination/evolution of these techniques) played important roles in elucidating bacterial biological complexity and pathogenic traits, at the same time accelerating the development of therapeutic drugs and vaccines. This article summarizes the most recent technological and scientific advances in meningococcal biology and pathogenesis aimed at the development and characterization of vaccines against the pathogenic meningococci.
authors.affiliation: Dipartimento di Biologia Molecolare, via Fiorentina 1, Università degli Studi di Siena, 53100 Siena, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bernardini
authors.forename: Daniela
authors.initials: D
authors.lastname: Braconi
authors.forename: Paola
authors.initials: P
authors.lastname: Lusini
authors.forename: Annalisa
authors.initials: A
authors.lastname: Santucci
mesh_terms: D023281:Genomics / Q000379:methods*; D006801:Humans; D022401:Meningococcal Vaccines; D009345:Neisseria meningitidis / Q000235:genetics* / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics / Q000379:methods
chemical_list: D022401:Meningococcal Vaccines