title: Chemical and pharmacological studies of Oplopanax horridus, a North American botanical.
abstract: Oplopanax horridus (OH), or Devil's club, is an ethnobotanical used by the indigenous people native to the Pacific Northwest of North America. There are three species in the genus Oplopanax, and OH is the only species that is distributed in North America. Compared with the extensive research on OH's "cousin," American ginseng, there is comparatively little reported about the chemical makeup and pharmacological effects of OH. Nevertheless, there has been some research over the past few years that shows promise for the future usage perspectives of OH. To date, 17 compounds were isolated and elucidated, including polyynes, glycosides, lignans, and polyenes, with most of the attention being paid to the polyynes. Gas chromatography (GC) and high-performance liquid chromatography (HPLC) were used to determine the contents of volatile compounds and polyynes in the essential oil and extracts of OH. For the pharmacological studies, antibacterial and antidiabetes effects of polyynes were reported. Our recent study has focused more on the anticancer effects of OH and the involved mechanisms of action. In this review, we will summarize the research status in the botany, phytochemistry, and pharmacology of OH.
authors.affiliation: Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Calway
authors.forename: Guang-Jian
authors.initials: GJ
authors.lastname: Du
authors.forename: Chong-Zhi
authors.initials: CZ
authors.lastname: Wang
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Chun-Su
authors.initials: CS
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009656:North America; D028002:Oplopanax / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D053279:Polyynes / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D053279:Polyynes
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