title: Vascularized anal autotransplantation model in rats: preliminary report.
abstract: Ostomy has served as an effective surgery for various anorectal disfunctions. However, it must also be noted that those patients suffered greatly from stresses caused by their stoma. Many alternative therapies have been developed, but none have solved this critical issue. Meanwhile, due to the improvements in operative methods and immunosuppressive therapy, allotranplantation has gained great popularity in recent years. Therefore, we began development of an anal transplantation model. The operation was performed in six adult Wistar rats that were divided into two groups. Group 1 underwent vascular anastomoses, while group 2 did not Group 1 grafts survived, fully recovering anal function. However, many of the group 2 grafts did not survive; those that did survive showed major defects in their anus, never recovering anal function. We succeeded in establishing the rat anal transplantation model utilizing super-microsurgery. While research in anal transplantation was behind compared to that in other fields, we hope that this model will bring significant possibilities for the future.
authors.affiliation: Department of Plastic Surgery, University of Tokyo, Tokyo, Japan. arakij-pla@h.u-tokyo.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Araki
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: M
authors.initials: M
authors.lastname: Narushima
authors.forename: T
authors.initials: T
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: I
authors.initials: I
authors.lastname: Koshima
mesh_terms: D001003:Anal Canal / Q000601:surgery* / Q000637:transplantation*; D000714:Anastomosis, Surgical; D000818:Animals; D003672:Defecation; D006085:Graft Survival; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents