title: Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength.
abstract: Monodispersed complex nano-particles were synthesized simply by mixing alginic acid (ALG-H) with poly[(2-dimethylamino) ethyl methacrylate] (PDEMA) in pure water without any surfactants or additives. The structure and properties of the nano-particles were extensively studied. The surface charges and average sizes of the nano-particles were varied with the composition of ALG-H and PDEMA. The nano-particles were formed through electrostatic attraction force, and they were very stable in pure water, but dissociated in salt solutions. An anticancer drug (doxorubicin) was loaded in the nano-particles and released in different saline solutions. The release profiles revealed that the drug release could be controlled by adjusting the pH and salt concentrations. The nano-particles displayed apparent advantages such as simple preparation process, low cost, free of organic solvents, size controllable, biodegradable and biocompatible.
authors.affiliation: School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.forename: Caihua
authors.initials: C
authors.lastname: Ni
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry* / Q000648:ultrastructure; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009994:Osmolar Concentration; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D012995:Solubility; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000464:Alginates; D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C520965:alginic acid-poly(2-(diethylamino)ethyl methacrylate); D012965:Sodium Chloride; D004317:Doxorubicin