title: Clinical efficacy of a xenogeneic collagen matrix in augmenting keratinized mucosa around implants: a randomized controlled prospective clinical trial.
abstract: OBJECTIVE
  The aim of this controlled randomized clinical trial was to evaluate the efficacy of a xenogeneic collagen matrix (CM) to augment the keratinized tissue around implants supporting prosthetic restorations at 6 months when compared with the standard treatment, the connective tissue autograft, CTG).
  
  
  METHODS
  This randomized longitudinal parallel controlled clinical trial studied 24 patients with at least one location with minimal keratinized tissue (≤1 mm).
  
  
  METHODS
  The 6-month width of keratinized tissue. As secondary outcomes the esthetic outlook, the maintenance of peri-implant mucosal health and the patient morbidity were assessed pre-operatively and 1, 3, and 6 months post-operatively.
  
  
  RESULTS
  At 6 months, Group CTG attained a mean width of keratinized tissue of 2.75 (1.5) mm, while the corresponding figure in Group CM was 2.8 (0.4) mm, the inter-group differences not being statistically significant. The surgical procedure in both groups did not alter significantly the mucosal health in the affected abutments. There was a similar esthetic result and significant increase in the vestibular depth in both groups as a result of the surgery. In the CM group it changed from 2.2 (3.3) to 5.1 (2.5) mm at 6 months. The patients treated with the CM referred less pain, needed less pain medication, and the surgical time was shorter, although these differences were not statistically significant when compared with the CTG group.
  
  
  CONCLUSIONS
  These results prove that this new CM was as effective and predictable as the CTG for attaining a band of keratinized tissue.
authors.affiliation: Graduate Periodontology, Faculty of Odontology, University Complutense of Madrid and Branemark Osseointegration Center, Madrid.
authors.forename: Ramón
authors.initials: R
authors.lastname: Lorenzo
authors.forename: Virginia
authors.initials: V
authors.lastname: García
authors.forename: Marco
authors.initials: M
authors.lastname: Orsini
authors.forename: Conchita
authors.initials: C
authors.lastname: Martin
authors.forename: Mariano
authors.initials: M
authors.lastname: Sanz
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use*; D003238:Connective Tissue / Q000637:transplantation; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004955:Esthetics, Dental; D005260:Female; D005889:Gingival Recession / Q000517:prevention & control; D006801:Humans; D007633:Keratins; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery; D017622:Periodontal Attachment Loss / Q000517:prevention & control; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D013997:Time Factors; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D007633:Keratins; D003094:Collagen