title: Ribosomal RNA evidence of ocular Chlamydia trachomatis infection following 3 annual mass azithromycin distributions in communities with highly prevalent trachoma.
abstract: Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7).
authors.affiliation: FI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, CA 94143-0412, USA. jeremy.keenan@ucsf.edu
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Keenan
authors.forename: Berhan
authors.initials: B
authors.lastname: Ayele
authors.forename: Teshome
authors.initials: T
authors.lastname: Gebre
authors.forename: Jeanne
authors.initials: J
authors.lastname: Moncada
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Stoller
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Zhou
authors.forename: Travis C
authors.initials: TC
authors.lastname: Porco
authors.forename: Charles E
authors.initials: CE
authors.lastname: McCulloch
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Gaynor
authors.forename: Paul M
authors.initials: PM
authors.lastname: Emerson
authors.forename: Julius
authors.initials: J
authors.lastname: Schachter
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Lietman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods; D017963:Azithromycin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification*; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D011314:Preventive Health Services; D012329:RNA, Bacterial / Q000032:analysis* / Q000235:genetics; D012335:RNA, Ribosomal / Q000032:analysis* / Q000235:genetics; D018709:Statistics, Nonparametric; D014141:Trachoma / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D017963:Azithromycin
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