title: Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.
abstract: The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.
authors.affiliation: University of Wisconsin, Madison, Wisconsin, USA. nnj@medicine.wisc.edu
authors.forename: Nizar N
authors.initials: NN
authors.lastname: Jarjour
authors.forename: Serpil C
authors.initials: SC
authors.lastname: Erzurum
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Bleecker
authors.forename: William J
authors.initials: WJ
authors.lastname: Calhoun
authors.forename: Mario
authors.initials: M
authors.lastname: Castro
authors.forename: Suzy A A
authors.initials: SA
authors.lastname: Comhair
authors.forename: Kian Fan
authors.initials: KF
authors.lastname: Chung
authors.forename: Douglas
authors.initials: D
authors.lastname: Curran-Everett
authors.forename: Raed A
authors.initials: RA
authors.lastname: Dweik
authors.forename: Sean B
authors.initials: SB
authors.lastname: Fain
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fitzpatrick
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Gaston
authors.forename: Elliot
authors.initials: E
authors.lastname: Israel
authors.forename: Annette
authors.initials: A
authors.lastname: Hastie
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
authors.forename: Fernando
authors.initials: F
authors.lastname: Holguin
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Levy
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Meyers
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Moore
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Peters
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Sorkness
authors.forename: W Gerald
authors.initials: WG
authors.lastname: Teague
authors.forename: Sally E
authors.initials: SE
authors.lastname: Wenzel
authors.forename: William W
authors.initials: WW
authors.lastname: Busse
mesh_terms: D000293:Adolescent; D000328:Adult; D056151:Airway Remodeling; D001249:Asthma / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis; D001999:Bronchoscopy; D002648:Child; D002985:Clinical Protocols; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
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