title: Covalent linkage of N-methyl-6-oxyquinolinium betaine to trehalose.
abstract: The common route to link quinolinium and pyridinium fluorophores to biomolecules via bromoacetic acid has failed in labeling the disaccharide trehalose with N-methyl-6-oxyquinolinium betaine: the unexpected, extremely high instability of the N-carboxymethyl ester was overcome by direct N-alkylation of the quinoline derivative with trehalose triflate.
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
authors.forename: Falko
authors.initials: F
authors.lastname: Berndt
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sajadi
authors.forename: Nikolaus P
authors.initials: NP
authors.lastname: Ernsting
authors.forename: Rainer
authors.initials: R
authors.lastname: Mahrwald
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014199:Trehalose / Q000737:chemistry*
chemical_list: D001622:Betaine; D014199:Trehalose