title: Elimination of onchocerciasis from Africa: possible?
abstract: Human onchocerciasis, a parasitic disease found in 28 African countries, six Latin American countries and Yemen, causes blindness and severe dermatological problems. In 1987, efforts to control this infection shifted from vector approaches to include the mass distribution of ivermectin - a drug donated by Merck & Co. for disease control in Africa and for disease elimination in the Americas. Currently, almost 25 years later, with the Americas being highly successful and now approaching elimination, new evidence points towards the possibility of successful elimination in Africa. We suggest several major changes in the programmatic approach that through focused goal-directed effort could achieve global elimination of onchocerciasis by 2025.
authors.affiliation: Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA. mackenz8@msu.edu
authors.forename: Charles D
authors.initials: CD
authors.lastname: Mackenzie
authors.forename: Mamoun M
authors.initials: MM
authors.lastname: Homeida
authors.forename: Adrian D
authors.initials: AD
authors.lastname: Hopkins
authors.forename: Joni C
authors.initials: JC
authors.lastname: Lawrence
mesh_terms: D000349:Africa / Q000453:epidemiology; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D007300:Insect Control / Q000379:methods*; D007303:Insect Vectors / Q000469:parasitology; D007559:Ivermectin / Q000627:therapeutic use; D009855:Onchocerciasis / Q000453:epidemiology / Q000517:prevention & control*; D012843:Simuliidae / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D007559:Ivermectin