title: Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features.
abstract: The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.
authors.affiliation: Department of Genetics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Jaqueline Carvalho
authors.initials: JC
authors.lastname: de Oliveira
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Scrideli
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Andressa Gois
authors.initials: AG
authors.lastname: Morales
authors.forename: Julia Alejandra
authors.initials: JA
authors.lastname: Pezuk
authors.forename: Rosane de Paula
authors.initials: Rde P
authors.lastname: Queiroz
authors.forename: José Andres
authors.initials: JA
authors.lastname: Yunes
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Brandalise
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000235:genetics* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D035683:MicroRNAs