title: Synthesis of (+)-phenserine using an interrupted Fischer indolization reaction.
abstract: A concise synthesis of the Alzheimer's therapeutic (+)-phenserine is described. The approach features an interrupted Fischer indolization to construct the pyrrolidinoindoline core, in addition to a classical resolution to arrive at phenserine in enantioenriched form.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
authors.forename: Alex W
authors.initials: AW
authors.lastname: Schammel
authors.forename: Grace
authors.initials: G
authors.lastname: Chiou
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002800:Cholinesterase Inhibitors; D007211:Indoles; D011759:Pyrrolidines; D010830:Physostigmine; C092280:phenserine