title: Identifying temporal codes in spontaneously active sensory neurons.
abstract: The manner in which information is encoded in neural signals is a major issue in Neuroscience. A common distinction is between rate codes, where information in neural responses is encoded as the number of spikes within a specified time frame (encoding window), and temporal codes, where the position of spikes within the encoding window carries some or all of the information about the stimulus. One test for the existence of a temporal code in neural responses is to add artificial time jitter to each spike in the response, and then assess whether or not information in the response has been degraded. If so, temporal encoding might be inferred, on the assumption that the jitter is small enough to alter the position, but not the number, of spikes within the encoding window. Here, the effects of artificial jitter on various spike train and information metrics were derived analytically, and this theory was validated using data from afferent neurons of the turtle vestibular and paddlefish electrosensory systems, and from model neurons. We demonstrate that the jitter procedure will degrade information content even when coding is known to be entirely by rate. For this and additional reasons, we conclude that the jitter procedure by itself is not sufficient to establish the presence of a temporal code.
authors.affiliation: Neuroscience Program, Ohio University, Athens, Ohio, United States of America.
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Neiman
authors.forename: David F
authors.initials: DF
authors.lastname: Russell
authors.forename: Michael H
authors.initials: MH
authors.lastname: Rowe
mesh_terms: D000200:Action Potentials; D000818:Animals; D005399:Fishes; D007257:Information Theory; D011984:Sensory Receptor Cells / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D014426:Turtles
references.citation: Science. 1991 Jun 28;252(5014):1854-7
references.pmid: 2063199
references.citation: Nat Neurosci. 2005 May;8(5):673-8
references.pmid: 15806098
references.citation: Trends Neurosci. 2008 Aug;31(8):428-34
references.pmid: 18603311
references.citation: Exp Brain Res. 2000 Feb;130(3):277-97
references.pmid: 10706428
references.citation: Eur Phys J Spec Top. 2010 Sep;187(1):179-187
references.pmid: 20975925
references.citation: J Neurosci. 2001 Jul 15;21(14):5328-43
references.pmid: 11438609
references.citation: J Comp Physiol A. 1998 Jan;182(1):89-101
references.pmid: 9447716
references.citation: J Physiol. 1926 Apr 23;61(2):151-71
references.pmid: 16993780
references.citation: Science. 2004 Jun 25;304(5679):1986-9
references.pmid: 15218153
references.citation: Exp Brain Res. 2011 May;210(3-4):353-71
references.pmid: 21267548
references.citation: Brain Res. 2012 Jan 24;1434:226-42
references.pmid: 21890114
references.citation: J Neurosci. 2007 Jan 24;27(4):771-81
references.pmid: 17251416
references.citation: Phys Rev Lett. 2009 Dec 11;103(24):248105
references.pmid: 20366234
references.citation: J Neurosci. 2000 Sep 1;20(17):6672-83
references.pmid: 10964972
references.citation: J Neurophysiol. 1996 Apr;75(4):1345-64
references.pmid: 8727382
references.citation: J Neurophysiol. 2004 Jul;92(1):492-509
references.pmid: 14573556
references.citation: Proc Biol Sci. 1995 Dec 22;262(1365):259-65
references.pmid: 8587884
references.citation: J Neurophysiol. 2006 May;95(5):2933-46
references.pmid: 16495358
references.citation: Phys Rev Lett. 2007 Dec 14;99(24):248103
references.pmid: 18233494
references.citation: PLoS Comput Biol. 2008 Mar 07;4(3):e1000025
references.pmid: 18369423
references.citation: J Neurosci. 2005 Jun 1;25(22):5323-32
references.pmid: 15930380
references.citation: Phys Rev Lett. 2008 Oct 10;101(15):154101
references.pmid: 18999602
references.citation: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):735-40
references.pmid: 9012854
references.citation: Nat Neurosci. 1999 Nov;2(11):947-57
references.pmid: 10526332
references.citation: Curr Opin Neurobiol. 1991 Aug;1(2):229-35
references.pmid: 1821186
references.citation: J Neurosci. 2011 Aug 3;31(31):11313-27
references.pmid: 21813691
references.citation: Science. 1995 Jun 9;268(5216):1503-6
references.pmid: 7770778
references.citation: J Neurophysiol. 2000 Mar;83(3):1224-42
references.pmid: 10712451
references.citation: Phys Rev Lett. 2004 Nov 12;93(20):204103
references.pmid: 15600929
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt 1):021905
references.pmid: 19391776
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Apr;71(4 Pt 2):045201
references.pmid: 15903714
references.citation: J Neurophysiol. 1973 Mar;36(2):205-25
references.pmid: 4350356
references.citation: Phys Rev Lett. 2004 Feb 27;92(8):080601
references.pmid: 14995762
references.citation: J Neurophysiol. 2007 Oct;98(4):1871-82
references.pmid: 17671103
references.citation: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5411-6
references.pmid: 9144251
references.citation: Phys Rev Lett. 2009 May 15;102(19):194102
references.pmid: 19518956
references.citation: Science. 2008 Feb 22;319(5866):1108-11
references.pmid: 18292344
references.citation: J Neurosci. 2010 Oct 13;30(41):13558-66
references.pmid: 20943897
references.citation: Pac Symp Biocomput. 1998;:621-32
references.pmid: 9697217
references.citation: J Neurophysiol. 2010 Oct;104(4):1955-68
references.pmid: 20685928
references.citation: J Neurosci. 2009 May 6;29(18):5964-73
references.pmid: 19420262
references.citation: J Neurosci. 1997 May 1;17(9):3312-21
references.pmid: 9096164
references.citation: J Comput Neurosci. 1995 Jun;2(2):149-62
references.pmid: 8521284
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 1):061915
references.pmid: 16089773
references.citation: J Neurophysiol. 2011 Apr;105(4):1798-814
references.pmid: 21307329
references.citation: J Neurophysiol. 2004 Jul;92(1):665-8
references.pmid: 14999053
references.citation: J Neurophysiol. 2006 Apr;95(4):2541-52
references.pmid: 16354733
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug;80(2 Pt 1):021919
references.pmid: 19792163
references.citation: PLoS Comput Biol. 2011 May;7(5):e1002041
references.pmid: 21573206
references.citation: J Neurosci. 2009 Jan 14;29(2):334-50
references.pmid: 19144834
references.citation: Network. 1996;7(1):61-85
references.pmid: 29480147
references.citation: Science. 1997 Mar 21;275(5307):1805-8
references.pmid: 9065407