title: Anti-genotoxic potential of casein phosphopeptides (CPPs): a class of fermented milk peptides against low background radiation and prevention of cancer in radiation workers.
abstract: BACKGROUND
  Radiation workers are constantly exposed to low background radiation which is their occupational hazard. This continuous and prolonged exposure produces genotoxicity and cancerous condition in many workers. The authors have tested casein phosphopeptides (CPP) as a radioprotectant against low background radiation using animal models.
  
  
  METHODS
  Fermented milk was produced by addition of a bacterial culture, Lactobacillus acidophilus to a commercially available milk brand. After the fermentation process is completed in the milk, CPP is isolated from fermented milk by enzymatic hydrolysis-based method. The radioprotective role of CPP was proved using albino mice and Catla catla fish.
  
  
  RESULTS
  The micronucleus assay showed higher level of cell deformation and micronucleus formation in the control animal cells than the test animal cells. CPP has found to be having radioprotective activity potential.
  
  
  CONCLUSIONS
  This radioprotective potential of CPP can be harnessed to produce formulations which can be used by radiation workers and personnel exposed to low ionization background as an occupational hazard, thus reducing the risk and preventing any type of cancer.
authors.affiliation: Department of Biotechnology, National Institute of Technology (NIT), Raipur, Chhattisgarh, India. balajiraja_vlr@yahoo.com
authors.forename: R Balaji
authors.initials: RB
authors.lastname: Raja
authors.forename: Kantha D
authors.initials: KD
authors.lastname: Arunachalam
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage*; D002347:Carps / Q000502:physiology*; D002364:Caseins / Q000008:administration & dosage; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D004195:Disease Models, Animal; D005285:Fermentation; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D015162:Micronucleus Tests; D008892:Milk; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D009784:Occupational Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects; D010748:Phosphopeptides / Q000008:administration & dosage*; D011827:Radiation; D011835:Radiation Protection; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D011877:Radionuclide Imaging
chemical_list: D016587:Antimutagenic Agents; D002364:Caseins; D003037:Cobalt Radioisotopes; D010748:Phosphopeptides; D011837:Radiation-Protective Agents