title: [Invasive carcinoma arising in breast microglandular adenosis: a clinicopathologic study of three cases and review of the literature].
abstract: OBJECTIVE
  To study the clinicopathologic features, immunophenotypes and differential diagnoses of invasive carcinoma arising in breast microglandular adenosis (MGACA).
  
  
  METHODS
  Clinical and pathologic findings of 3 cases of MGACA were analyzed by histomorphology and immunohistochemical staining of CK7, S-100 protein, ER, PR, HER2, SMA, MSA, p63 and PAS. Literatures were reviewed.
  
  
  RESULTS
  (1) Histologically, 3 tumors all showed a spectrum of glandular proliferations ranging from microglandular adenosis (MGA) to atypical microglandular adenosis (AMGA) to in situ carcinoma (DCIS) to invasive carcinoma. The invasive carcinoma component was ductal in case 1, and matrix-producing in case 2 and case 3. (2) All epithelial cells in MGA, AMGA, DCIS and MGACA were positive for CK7 and S-100 protein, but were negative for ER and HER2. PR was negative in case 1 and case 2 but was low positive in case 3. Myoepithelial cell differentiation was not demonstrated in MGA, AMGA, DCIS and MGACA by immunohistochemical staining for SMA, MSA or p63. PAS staining showed the presence of basement membrane in MGA, AMGA and DCIS, except MGACA.
  
  
  CONCLUSIONS
  MGACA is an extremely rare tumor of the breast and has distinct morphological and immunohistochemical features. Further studies are needed to evaluate the clinical behavior of this rare neoplasm.
authors.affiliation: Department of Pathology, Cancer Hospital and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Ruo-hong
authors.initials: RH
authors.lastname: Shui
authors.forename: Yu-fan
authors.initials: YF
authors.lastname: Cheng
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Yang
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005348:Fibrocystic Breast Disease / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000378:metabolism; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D011230:Precancerous Conditions / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D011980:Receptors, Progesterone / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D053552:Keratin-7; D011980:Receptors, Progesterone; D009418:S100 Proteins