title: Origin and plasticity of MHC I-associated self peptides.
abstract: Endogenous peptides presented by MHC I molecules represent the essence of self for CD8 T lymphocytes. These MHC I peptides (MIPs) regulate all key events that occur during the lifetime of CD8 T cells. CD8 T cells are selected on self-MIPs, sustained by self-MIPs, and activated in the presence of self-MIPs. Recently, large-scale mass spectrometry studies have revealed that the self-MIP repertoire is more complex and plastic than previously anticipated. The composition of the self-MIP repertoire varies from one cell type to another and can be perturbed by cell-intrinsic and -extrinsic factors including dysregulation of cellular metabolism and infection. The complexity and plasticity of the self-MIP repertoire represent a major challenge for the maintenance of self tolerance and can have pervasive effects on the global functioning of the immune system.
authors.affiliation: Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Canada.
authors.forename: Danielle
authors.initials: D
authors.lastname: de Verteuil
authors.forename: Diana Paola
authors.initials: DP
authors.lastname: Granados
authors.forename: Pierre
authors.initials: P
authors.lastname: Thibault
authors.forename: Claude
authors.initials: C
authors.lastname: Perreault
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002472:Cell Transformation, Viral / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D010455:Peptides / Q000276:immunology*; D046988:Proteasome Endopeptidase Complex / Q000276:immunology; D017634:Self Tolerance
chemical_list: D015395:Histocompatibility Antigens Class I; D010455:Peptides; D046988:Proteasome Endopeptidase Complex