title: Serum microRNA expression in pregnancies with  preeclampsia.
abstract: Preeclampsia continues to be a mortal disease of pregnant  women throughout the world. Recently, geneticists, allied with obstetricians,  have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small,  noncoding RNA molecules. They are critical posttranscriptional regulators of  gene expression. We extracted circulating miRNA from maternal plasma and  quantified mir-152 and mir-210. We found up-regulated miR-210 levels as well as  down-regulated mir-152 levels in preeclampsia patients.We propose that  detection of increased mir-210 levels in maternal serum could be used to  improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
authors.affiliation: Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey. gunel@istanbul.edu.tr
authors.forename: T
authors.initials: T
authors.lastname: Gunel
authors.forename: Y G
authors.initials: YG
authors.lastname: Zeybek
authors.forename: P
authors.initials: P
authors.lastname: Akçakaya
authors.forename: I
authors.initials: I
authors.lastname: Kalelioğlu
authors.forename: A
authors.initials: A
authors.lastname: Benian
authors.forename: H
authors.initials: H
authors.lastname: Ermis
authors.forename: K
authors.initials: K
authors.lastname: Aydınlı
mesh_terms: D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation
chemical_list: C550856:MIRN152 microRNA, human; C543800:MIRN210 microRNA, human; D035683:MicroRNAs