title: Acute urine retention induced by ceftriaxone.
abstract: Ceftriaxone is known to cause biliary pseudolithiasis and, rarely, nephrolithiasis. When used in neonates receiving intravenous calcium, fatal lung and kidney calcifications occur. There is no satisfactory explanation for the pseudolithiasis, and the mechanism of stone formation remains unknown. Herein, we report a child with acute urinary retention (AUR) secondary to ceftriaxone therapy. The AUR developed on the second hospital day. The urinary excretion of uric acid was elevated. In retrospect, there was a positive paternal family history of gout and stones. A positive family history of gout or stones is a pointer to the possibility of AUR or urolithiasis in patients on treatment with ceftriaxone. If urinary symptoms develop, it is worth checking for crystalluria. This will avoid many unnecessary investigations and procedures.
authors.affiliation: Department of Pediatrics Nephrology, University of Jordan, Amman, Jordan. kachbl@yahoo.com
authors.forename: Kamal F
authors.initials: KF
authors.lastname: Akl
authors.forename: Amira T
authors.initials: AT
authors.lastname: Masri
authors.forename: Maali M
authors.initials: MM
authors.lastname: Hjazeen
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008581:Meningitis / Q000188:drug therapy; D014527:Uric Acid / Q000652:urine; D016055:Urinary Retention / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D014527:Uric Acid; D002443:Ceftriaxone