title: Protein profiling of cerebrospinal fluid.
abstract: The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.
authors.affiliation: Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Anja.hviid.simonsen@rh.regionh.dk
authors.forename: Anja H
authors.initials: AH
authors.lastname: Simonsen
mesh_terms: D053000:Analytic Sample Preparation Methods; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis* / Q000302:isolation & purification; D040081:Protein Array Analysis; D012015:Reference Standards; D013048:Specimen Handling; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods* / Q000592:standards
chemical_list: D002556:Cerebrospinal Fluid Proteins