title: Three initial diets for management of mild acute pancreatitis: a meta-analysis.
abstract: OBJECTIVE
  To compare non-liquid and clear-liquid diets, and to assess whether the latter is the optimal treatment for mild acute pancreatitis.
  
  
  METHODS
  The Cochrane Library, PUBMED, EMBASE, EBM review databases, Science Citation Index Expanded, and several Chinese databases were searched up to March 2011. Randomized controlled trials (RCTs) that compared non-liquid with clear-liquid diets in patients with mild acute pancreatitis were included. A meta-analysis was performed using available evidence from RCTs.
  
  
  RESULTS
  Three RCTs of adequate quality involving a total of 362 participants were included in the final analysis. Compared to liquid diet, non-liquid diet significantly decreased the length of hospitalization [mean difference (MD): 1.18, 95% CI: 0.82-1.55; P﹤0.00001] and total length of hospitalization (MD: 1.31, 95% CI: 0.45-2.17; P = 0.003). The subgroup analysis showed solid diet was more favorable than clear liquid diet in the length of hospitalization, with a pooled MD being -1.05 (95% CI: -1.43 to -0.66; P﹤0.00001). However, compared with clear liquid diet, both soft and solid diets did not show any significant differences for recurrence of pain after re-feeding, either alone [relative risk (RR): 0.95; 95% CI: 0.51-1.87; P = 0.88] and (RR: 1.22; 95% CI: 0.69-2.16; P = 0.49), respectively, or analyzed together as non-liquid diet (RR: 0.80; 95% CI: 0.47-1.36; P = 0.41).
  
  
  CONCLUSIONS
  The non-liquid soft or solid diet did not increase pain recurrence after re-feeding, compared with the clear-liquid diet. The non-liquid diet reduced hospitalization.
authors.affiliation: Key Laboratory of Digestive System Tumors, Gansu Province, Lanzhou 730000, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Meng
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Li
authors.forename: Wen-Ce
authors.initials: WC
authors.lastname: Zhou
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Zhu
mesh_terms: D000328:Adult; D016208:Databases, Factual; D004032:Diet; D019468:Disease Management; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000178:diet therapy*; D016032:Randomized Controlled Trials as Topic
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