title: Prognostic significance of intracranial pressure monitoring and intracranial hypertension in severe brain trauma patients.
abstract: Since without prospective randomized studies it is not possible to have a clear attitude towards the importance of intracranial pressure monitoring, this study was aimed at examining the prognostic effect of the intracranial pressure monitoring and intracranial pressure oriented therapy in severe brain trauma patients, and at defining optimal intracranial pressure values for starting the treatment. Two groups of patients were treated in the study, one consisted of 32 patients undergoing intracranial pressure monitoring and the second group of 29 patients without intracranial pressure monitoring in the control group. The study was prospective with groups randomized. There were 53% survivals in the intracranial pressure monitored patients and 34% in the control group, with no significant difference in the survival rate between the two groups (chi2=2.11; p=0.15; p>0.05). The average intracranial pressure in the patients with intracranial hypertension who died was 27 mm Hg, while in the patients who survived the average intracranial pressure was significantly lower (Student's t test: t=2.91; p=0.008; p<0.01) and it was 18 mm Hg. We recommend starting intracranial pressure oriented therapy when the patient's intracranial pressure exceeds 18 mmHg during 2 hours of monitoring.
authors.affiliation: University Clinical Centre Nis, Nis, Department of Neurosurgery. aleko018@yahoo.co.uk
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kostić
authors.forename: Ivan
authors.initials: I
authors.lastname: Stefanović
authors.forename: Vesna
authors.initials: V
authors.lastname: Novak
authors.forename: Dragan
authors.initials: D
authors.lastname: Veselinović
authors.forename: Goran
authors.initials: G
authors.lastname: Ivanov
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Veselinović
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000209:etiology; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011379:Prognosis; D015996:Survival Rate