title: [Relationship between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility of ischemic stroke: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the relationship between the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and the susceptibility of ischemic stroke among different ethnic populations.
  
  
  METHODS
  The databases of MEDLINE, EMBASE, Cochrane Library and others were searched. And a total of 17 studies published in English between 2000 and October 2010 on the association of MTHFR gene C677T polymorphism with ischemic stroke were selected. A comprehensive quantitative analysis was performed by meta-analysis.
  
  
  RESULTS
  The results showed that the pooled OR values of ischemic stroke with TT and CC genotype were 1.30 (95%CI: 1.11 to 1.52) and 0.88 (95%CI: 0.79 to 0.98) respectively. And when sub-grouped by ethnic populations, the Caucasians were more likely than other populations to suffer ischemic stroke. There was a low probability of publication bias.
  
  
  CONCLUSIONS
  The presence of MTHFR TT gene is associated with an elevated risk of developing ischemic stroke, especially in Caucasians.
authors.affiliation: Department of Clinical Epidemiology, China Medical University, Shenyang, China.
authors.forename: Hui-hui
authors.initials: HH
authors.lastname: Yu
authors.forename: Wen-liang
authors.initials: WL
authors.lastname: Zhang
authors.forename: Jing-pu
authors.initials: JP
authors.lastname: Shi
mesh_terms: D002545:Brain Ischemia / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D020521:Stroke / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)