title: Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin.
abstract: BACKGROUND
  In the recent case-control study, we showed an inverse association between peptic ulcer and angiotensin type 1 receptor (AT1R) blockers (ARBs) or HMG-Co A reductase inhibitors (statins). The aim was to evaluate whether the genotypes of uptake and efflux transporters of ARBs and statins relate to the presence of peptic ulcer and/or ulcer bleeding associated with aspirin use.
  
  
  METHODS
  Patients taking 100mg of enteric-coated aspirin for cardiovascular diseases who also participated in endoscopic surveillance were studied. SLCO1B, ABCC2, ABCG2, and MDR1 genotypes were determined by PCR or PCR-RFLP.
  
  
  RESULTS
  492 patients enrolled including 78 with peptic ulcer. The frequencies of the SLCO1B1 521TT genotype were significantly higher in the ulcer group (p=0.006) compared to the controls. After adjustment for significant factors, the SLCO1B1 1b haplotype was significantly associated with peptic ulcer (OR, 3.64; 95% CI, 1.81-7.29).
  
  
  CONCLUSIONS
  SLCO1B1 1b haplotype may identify patients at increased risk for aspirin-induced peptic ulcer.
authors.affiliation: Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan. shiotani@med.kawasaki-m.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.forename: Takahisa
authors.initials: T
authors.lastname: Murao
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tarumi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunoki
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects; D007564:Japan; D027381:Liver-Specific Organic Anion Transporter 1; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D000089762:Multidrug Resistance-Associated Protein 2; D027361:Organic Anion Transporters / Q000235:genetics*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C000715087:ABCC2 protein, human; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D027381:Liver-Specific Organic Anion Transporter 1; D000089762:Multidrug Resistance-Associated Protein 2; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human; D001241:Aspirin