title: Neurobehavioral effects of acute exposure to isoparaffinic and cycloparaffinic hydrocarbons.
abstract: This article reports neurobehavioral tests in rats with C5-C11 isoparaffinic and cycloparaffinic hydrocarbons. Testing, conducted shortly after exposure, evaluated the effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Isopentane and cyclopentane did not produce any evidence of acute central nervous system (CNS) effects at levels up to 20 000 mg/m(3). A C(6)/C(7) mixed cycloparaffinic solvent produced minor, reversible changes in latency to response in visual discrimination testing at 14 000 mg/m(3); the no-effect level was 4200 mg/m(3). A C(8) isoparaffin produced no effects at 14 000 mg/m(3), the highest level tested. A C(9)/C(11) isoparaffinic solvent produced minor acute CNS effects at 5000 mg/m(3), with 1500 mg/m(3) as the no-effect level. A C(10) cycloparaffinic solvent did not produce any statistically significant CNS effects at 5000 mg/m(3). These studies were designed to provide data that may be useful in setting occupational exposure limits for C5-C11 isoparaffinic and cycloparaffinic hydrocarbons.
authors.affiliation: ExxonMobil Biomedical Sciences, Annandale, NJ 08801, USA. richard.h.mckee@exxonmobil.com
authors.forename: Richard H
authors.initials: RH
authors.lastname: McKee
authors.forename: J H C M
authors.initials: JH
authors.lastname: Lammers
authors.forename: H
authors.initials: H
authors.lastname: Muijser
authors.forename: David E
authors.initials: DE
authors.lastname: Owen
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D006838:Hydrocarbons / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D019055:No-Observed-Adverse-Effect Level; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000633:toxicity*; D023382:Toxicity Tests, Acute; D014796:Visual Perception / Q000187:drug effects
chemical_list: D000395:Air Pollutants, Occupational; D006838:Hydrocarbons; D012997:Solvents