title: The frailty syndrome: a comprehensive review.
abstract: The frailty syndrome is defined as unintentional weight and muscle loss, exhaustion, and declines in grip strength, gait speed, and activity. Evidence with respect to the clinical definition, epidemiology, mechanisms, interactions, assessment, prevention, and treatment of frailty in the older adult is reviewed.
authors.affiliation: Department of Human Environmental Studies, Central Michigan University, Mt. Pleasant, Michigan 48859, USA. heube1ra@cmich.edu
authors.forename: Roschelle A
authors.initials: RA
authors.lastname: Heuberger
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D005221:Fatigue; D016330:Frail Elderly; D006801:Humans; D009142:Musculoskeletal Physiological Phenomena; D055948:Sarcopenia; D013577:Syndrome; D015431:Weight Loss