title: Moderate intensities of leisure-time physical activity are associated with lower levels of high-sensitivity C-reactive protein in healthy middle-aged men.
abstract: Circulating C-reactive protein (CRP), reflective of systemic chronic low-grade inflammation, is a marker associated with cardiovascular disease (CVD). One of the mechanisms through which physical activity might promote cardiovascular health is by preventing changes in inflammation biomarkers, such as CRP. The present study examined the association of self-reported physical activity with an inflammation biomarker, high-sensitivity CRP (hs-CRP), in a population-based cohort of clinically healthy 58-year-old men. Compared with a sedentary lifestyle both moderate (1.81 [0.94-3.69] vs 1.28 [0.55-2.90] mg/L; P < .05) and vigorous physical activity (1.81 [0.94-3.69] vs 0.88 [0.42-1.81] mg/L; P < .001) were associated with decrease in hs-CRP levels. In summary, we identified an association between self-reported leisure time physical activity and hs-CRP in a cross-sectional study of healthy 58-year-old men, with decreased levels of CRP by increased intensities of physical activity.
authors.affiliation: Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Bergström
authors.forename: Carl Johan
authors.initials: CJ
authors.lastname: Behre
authors.forename: Caroline
authors.initials: C
authors.lastname: Schmidt
mesh_terms: D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007899:Leisure Activities; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D012016:Reference Values; D057185:Sedentary Behavior; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein