title: Peripheral assessment of the genes AQP4, PBP and TH in patients with Parkinson's disease.
abstract: Parkinson's disease (PD) typically appears in late middle-aged and in elderly persons progressing over a period of several years. The characteristic pathological features of PD patients include defective motor function and cognitive function affecting the quality of life of PD patients. Oxidative stress is considered to a play a central role along with various other factors in the pathogenesis of PD and the incidence and prevalence of the disease is incessantly increasing worldwide. The objective of the current study was to assess mRNA expressional changes of AQP4, TH and PBP in blood samples of control and patients with PD. The study included 30 healthy controls and 90 PD patients subjected to treatment through the entire period of the study. RNA isolation was carried out using blood samples of the subjects recruited in the study and used for RT-PCR analysis of AQP4, TH as well as PBP. The mRNA expressions of AQP4 and TH were found to be reduced whereas that of PBP was found to be elevated when compared with those of healthy control samples. The statistically analysed data were presented which could be helpful for appreciation of PD pathology reflecting in the blood samples of PD population.
authors.affiliation: Department of Biochemistry, University of Madras, Guindy-Maraimalai Campus, Chennai 600025, India.
authors.forename: S Thamizh
authors.initials: ST
authors.lastname: Thenral
authors.forename: A J
authors.initials: AJ
authors.lastname: Vanisree
mesh_terms: D051401:Aquaporin 4 / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*; D049488:Phosphatidylethanolamine Binding Protein / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D017931:DNA Primers; D049488:Phosphatidylethanolamine Binding Protein; D014446:Tyrosine 3-Monooxygenase
references.citation: J Investig Dermatol Symp Proc. 2001 Nov;6(1):115-21
references.pmid: 11764279
references.citation: DNA Res. 2006 Dec 31;13(6):275-86
references.pmid: 17213182
references.citation: Adv Enzymol Relat Areas Mol Biol. 1995;70:103-220
references.pmid: 8638482
references.citation: Arch Neurobiol (Madr). 1987 Sep-Oct;50(5):309-14
references.pmid: 3689090
references.citation: Neuroreport. 1999 Sep 29;10(14):2907-10
references.pmid: 10549795
references.citation: J Neurochem. 1996 Aug;67(2):443-62
references.pmid: 8764568
references.citation: J Neurosci Res. 1998 Nov 15;54(4):450-64
references.pmid: 9822156
references.citation: Biochim Biophys Acta. 1991 Oct 11;1080(1):78-82
references.pmid: 1932083
references.citation: Neurobiol Aging. 2008 Aug;29(8):1226-36
references.pmid: 17353068
references.citation: J Neurochem. 1993 Sep;61(3):1024-34
references.pmid: 8103078
references.citation: J Biol Chem. 2004 Apr 23;279(17):17515-23
references.pmid: 14766752
references.citation: Neuron. 2003 Sep 11;39(6):889-909
references.pmid: 12971891
references.citation: Arch Neurol. 2002 Oct;59(10):1541-50
references.pmid: 12374491
references.citation: J Neurosci. 1997 Jan 1;17(1):171-80
references.pmid: 8987746
references.citation: J Nucl Med. 2000 Jan;41(1):71-7
references.pmid: 10647607
references.citation: Circulation. 1996 May 1;93(9):1667-76
references.pmid: 8653872