title: Associations between cerebral and systemic endothelial function in migraine patients: a post-hoc study.
abstract: BACKGROUND
  There is a growing interest in the role of the endothelium in migraine. Recently, our group showed differences in endothelial function between the anterior and posterior cerebral circulation in healthy subjects, reduced vasodilatatory capacity of the posterior cerebral circulation and unimpaired systemic endothelial function in migraine patients without comorbidities. However, the relationship between cerebral and systemic endothelial function and the anterior and posterior cerebral endothelial function in migraine patients is still not clear.
  
  
  METHODS
  We compared cerebral and systemic endothelial function through post-hoc linear regression analysis of cerebrovascular reactivity (CVR) to L-arginine between the middle cerebral artery (MCA) and flow-mediated vasodilatation (FMD) of the right brachial artery and the posterior cerebral artery (PCA) and FMD in migraine patients without comorbidities and in healthy subjects. The anterior and posterior cerebral endothelial function was also compared using post-hoc linear regression analysis between CVR to L-arginine in the MCA and the PCA.
  
  
  RESULTS
  No significant correlation was found between CVR to L-arginine in the MCA and FMD and in the PCA and FMD in migraine patients with aura (p = 0.880 vs. p = 0.682), without aura (p = 0.153 vs. p = 0.179) and in healthy subjects (p = 0.869 vs. p = 0.662). On the other hand, we found a significant correlation between CVR to L-arginine in the MCA and PCA in migraine patients with aura (p = 0.004), without aura (p = 0.001) and in healthy subjects (p = 0.002). Detailed analysis of the linear regression between all migraine patients and healthy subjects did not show any difference in the regression coefficient (slope) (p = 0.382). However, a significant difference in curve elevation (intercept) was found (p = 0.002).
  
  
  CONCLUSIONS
  Our study suggests that the endothelial function in the cerebral and systemic circulation might be different in migraine patients without comorbidities, while that of the anterior and posterior cerebral circulation might be coupled. These results could improve understanding of endothelial function in migraine patients without comorbidities.
authors.affiliation: Department of Neurology, University Medical Centre Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia. perkodenis@yahoo.com
authors.forename: Denis
authors.initials: D
authors.lastname: Perko
authors.forename: Janja
authors.initials: J
authors.lastname: Pretnar-Oblak
authors.forename: Mišo
authors.initials: M
authors.lastname: Šabovič
authors.forename: Marjan
authors.initials: M
authors.lastname: Zaletel
authors.forename: Bojana
authors.initials: B
authors.lastname: Žvan
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation / Q000502:physiology
references.citation: BMC Neurol. 2010 Dec 01;10:119
references.pmid: 21122149
references.citation: Cerebrovasc Dis. 2004;18(4):346-9
references.pmid: 15523176
references.citation: J Physiol. 1992 Apr;449:183-96
references.pmid: 1522509
references.citation: Crit Care Med. 2003 Apr;31(4 Suppl):S221-30
references.pmid: 12682444
references.citation: Cephalalgia. 2009 Sep;29(9):987-96
references.pmid: 19689607
references.citation: Int Angiol. 2002 Sep;21(3):256-9
references.pmid: 12384647
references.citation: Thromb Res. 2007;119(2):217-22
references.pmid: 16504253
references.citation: Rev Neurol (Paris). 2005 Jul;161(6-7):689-91
references.pmid: 16141961
references.citation: Endothelium. 2007 Mar-Apr;14(2):73-80
references.pmid: 17497363
references.citation: Cerebrovasc Dis. 2004;17(2-3):128-33
references.pmid: 14707412
references.citation: Acta Neurol Scand. 2011 Oct;124(4):269-74
references.pmid: 21198449
references.citation: J Cereb Blood Flow Metab. 1997 Mar;17(3):309-15
references.pmid: 9119904
references.citation: Gerontology. 2001 May-Jun;47(3):131-5
references.pmid: 11340318
references.citation: Br J Pharmacol. 1996 Aug;118(7):1848-54
references.pmid: 8842453
references.citation: Brain Res Bull. 1995;38(4):365-9
references.pmid: 8535859
references.citation: Am J Physiol. 1990 Nov;259(5 Pt 2):H1396-401
references.pmid: 2240240
references.citation: J Appl Physiol (1985). 1998 Aug;85(2):537-42
references.pmid: 9688731
references.citation: J Am Coll Cardiol. 2002 Jan 16;39(2):257-65
references.pmid: 11788217
references.citation: Stroke. 2003 Mar;34(3):643-7
references.pmid: 12624285
references.citation: Headache. 2002 May;42(5):352-5
references.pmid: 12047335
references.citation: Stroke. 1993 Jul;24(7):1049-53; discussion 1053-4
references.pmid: 7686696
references.citation: Neurology. 2007 May 15;68(20):1694-700
references.pmid: 17502551
references.citation: Headache. 2007 Jan;47(1):45-51
references.pmid: 17355493
references.citation: Cephalalgia. 2003 Feb;23(1):39-42
references.pmid: 12534579
references.citation: Lancet. 1992 Nov 7;340(8828):1111-5
references.pmid: 1359209
references.citation: Cerebrovasc Dis. 2011;31(4):358-64
references.pmid: 21252504
references.citation: J Rheumatol. 1993 Jul;20(7):1187-8
references.pmid: 8371215
references.citation: Headache. 2007 Jan;47(1):104-10
references.pmid: 17355503
references.citation: J Neurol Sci. 1999 Mar 1;163(2):153-8
references.pmid: 10371076
references.citation: Cephalalgia. 2011 Apr;31(6):654-60
references.pmid: 21296807
references.citation: Br J Clin Pharmacol. 2000 Nov;50(5):397-404
references.pmid: 11069434
references.citation: Neurology. 2005 May 10;64(9):1573-7
references.pmid: 15883318