title: Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1-3 Axillary Lymph Node(s) Metastasis.
abstract: We evaluated the prognostic significance of lymph node ratio (LNR), number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 1-3 metastatic axillary lymph node(s). The most significant LNR threshold value separating patients in low- and high-risk groups with significant survival difference was 0.20 for disease-free survival (P < 0.001), 0.30 for locoregional recurrence-free survival (P < 0.001), and 0.15 for distant metastasis-free survival (P < 0.001), and the patients with lower LNR had better survival. All three LNR threshold values had independent prognostic significance in Cox analysis (P < 0.001 for all three of them). In conclusion, LNR is a useful tool in separating breast carcinoma patients with 1-3 metastatic lymph node(s) into low- and high-risk prognostic groups.
authors.affiliation: Third Department of Surgery, SB Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nüvit
authors.initials: N
authors.lastname: Duraker
authors.forename: Bakır
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authors.lastname: Batı
authors.forename: Davut
authors.initials: D
authors.lastname: Demir
authors.forename: Zeynep Civelek
authors.initials: ZC
authors.lastname: Caynak
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