title: Follicular-patterned tumors of the thyroid: the battle of benign vs. malignant vs. so-called uncertain.
abstract: This article will review the controversial area of follicular-patterned thyroid tumors. The literature is discussed with emphasis on pathologic diagnosis and the criteria for malignancy. In addition, the current state of knowledge regarding molecular markers and their utility in diagnosing benign from malignant nodules is described. Finally, the apparent lack of consistency with regard to results of certain immunohistochemical markers is included.
authors.affiliation: Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA. linus@mail.med.upenn.edu
authors.forename: Virginia A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: Zubair W
authors.initials: ZW
authors.lastname: Baloch
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000097:blood; D044963:Biopsy, Fine-Needle / Q000379:methods; D018265:Carcinoma, Papillary, Follicular / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
references.citation: Cancer. 1984 Aug 1;54(3):535-40
references.pmid: 6733684
references.citation: Cancer. 2001 Feb 1;91(3):505-24
references.pmid: 11169933
references.citation: Head Neck. 2010 Dec;32(12):1629-34
references.pmid: 20848402
references.citation: Arch Pathol Lab Med. 2011 May;135(5):569-77
references.pmid: 21526955
references.citation: Am J Clin Pathol. 2002 Jan;117(1):19-21
references.pmid: 11789725
references.citation: Am J Pathol. 1990 Sep;137(3):553-62
references.pmid: 1975986
references.citation: Otolaryngol Head Neck Surg. 2011 Feb;144(2):210-5
references.pmid: 21493418
references.citation: Am J Surg Pathol. 2002 Nov;26(11):1508-14
references.pmid: 12409728
references.citation: Surg Oncol. 2011 Mar;20(1):1-6
references.pmid: 19596568
references.citation: Am J Clin Pathol. 2002 Jan;117(1):143-50
references.pmid: 11789719
references.citation: Diagn Mol Pathol. 1995 Jun;4(2):113-21
references.pmid: 7551291
references.citation: Br J Clin Pract. 1994 Nov-Dec;48(6):334-6
references.pmid: 7848802
references.citation: Surgery. 1986 Dec;100(6):1068-77
references.pmid: 3787462
references.citation: Mod Pathol. 2000 Aug;13(8):861-5
references.pmid: 10955452
references.citation: J Med Assoc Thai. 1998 Oct;81(10):799-802
references.pmid: 9803073
references.citation: Am J Surg Pathol. 1992 Apr;16(4):392-400
references.pmid: 1373582
references.citation: Am J Clin Pathol. 2002 Oct;118(4):603-5; author reply 605-6
references.pmid: 12375649
references.citation: Endocr Pract. 2010 Nov-Dec;16(6):952-9
references.pmid: 20497934
references.citation: Head Neck. 1994 Nov-Dec;16(6):533-8
references.pmid: 7822175
references.citation: Am J Surg Pathol. 1996 Oct;20(10):1205-11
references.pmid: 8827026
references.citation: Virchows Arch. 2003 Jan;442(1):71-6
references.pmid: 12536317
references.citation: Thyroid. 1994 Summer;4(2):233-6
references.pmid: 7920009
references.citation: Cancer. 2004 Mar 15;100(6):1123-9
references.pmid: 15022277
references.citation: J Clin Pathol. 2007 Mar;60(3):244-50
references.pmid: 16798933
references.citation: Virchows Arch A Pathol Anat Histol. 1980;385(2):125-41
references.pmid: 7355566
references.citation: Am J Clin Pathol. 1999 Sep;112(3):311-6
references.pmid: 10478135
references.citation: Isr Med Assoc J. 2000 Sep;2(9):720-1
references.pmid: 11062782
references.citation: Surgery. 1995 Dec;118(6):1131-6; discussion 1136-8
references.pmid: 7491533
references.citation: Mod Pathol. 2001 Apr;14(4):338-42
references.pmid: 11301350
references.citation: Compr Ther. 1981 May;7(5):6-14
references.pmid: 7016424
references.citation: Endocr Pathol. 1997 Winter;8(4):283-292
references.pmid: 12114789
references.citation: Endocr Relat Cancer. 2005 Jun;12(2):245-62
references.pmid: 15947100
references.citation: Am J Clin Oncol. 2000 Feb;23(1):1-5
references.pmid: 10683064
references.citation: Mod Pathol. 2011 Apr;24 Suppl 2:S34-43
references.pmid: 21455199
references.citation: Am J Clin Pathol. 2008 Nov;130(5):736-44
references.pmid: 18854266
references.citation: Oncogene. 2005 Oct 6;24(44):6646-56
references.pmid: 16007166
references.citation: Surg Gynecol Obstet. 1985 May;160(5):409-13
references.pmid: 3992444
references.citation: Cancer. 2009 Dec 1;115(23):5421-31
references.pmid: 19658182
references.citation: Mod Pathol. 2011 Apr;24 Suppl 2:S10-8
references.pmid: 21455197
references.citation: Thyroid. 1999 May;9(5):421-7
references.pmid: 10365671
references.citation: Pathol Annu. 1994;29 ( Pt 2):99-120
references.pmid: 7936753
references.citation: Am J Surg Pathol. 1977 Jun;1(2):123-30
references.pmid: 602974
references.citation: Pathol Annu. 1983;18 Pt 1:221-53
references.pmid: 6877876
references.citation: Am J Surg Pathol. 2004 Oct;28(10):1336-40
references.pmid: 15371949
references.citation: Semin Diagn Pathol. 1985 May;2(2):101-22
references.pmid: 3843689
references.citation: Am J Clin Pathol. 2002 Jan;117(1):16-8
references.pmid: 11791591
references.citation: J Pathol. 2004 Feb;202(2):247-51
references.pmid: 14743508
references.citation: Arch Pathol Lab Med. 1993 Jun;117(6):631-5
references.pmid: 8503737
references.citation: Am J Pathol. 2002 Jun;160(6):2157-67
references.pmid: 12057919
references.citation: Int J Surg Pathol. 2000 Jul;8(3):181-183
references.pmid: 11493987
references.citation: Minerva Chir. 1998 Sep;53(9):751-6
references.pmid: 9866945
references.citation: Cancer Sci. 2011 Jan;102(1):288-94
references.pmid: 21070478
references.citation: Eur J Surg Oncol. 1999 Dec;25(6):599-605
references.pmid: 10556007
references.citation: Br J Surg. 1998 Aug;85(8):1125-8
references.pmid: 9718012