title: Highly enantioselective Mukaiyama aldol reaction in aqueous conditions using a chiral iron(II) bipyridine catalyst.
abstract: A highly enantioselective method for the catalytic Mukaiyama aldol reaction of silyl enol ethers with aldehydes in aqueous conditions was developed. The desired aldol products were obtained in excellent yields, diastereo- and enantioselectivities. Structural evidence of the pre-catalyst revealed an unprecedented heptadentate Fe(II) complex with the chiral bipyridine ligand.
authors.affiliation: Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec (Québec), G1V 0A6, Canada. thierry.ollevier@chm.ulaval.ca
authors.forename: Thierry
authors.initials: T
authors.lastname: Ollevier
authors.forename: Baptiste
authors.initials: B
authors.lastname: Plancq