title: Porcine-derived xenograft combined with a soft cortical membrane versus extraction alone for implant site development: a clinical study in humans.
abstract: BACKGROUND
  An adequate alveolar crest is essential for implant placement in terms of esthetics and function. The objective of this randomized clinical trial was to compare the preservation of the alveolar ridge dimensions following tooth extraction using porcine-derived xenograft combined with a membrane versus extraction-alone (EXT) sites.
  
  
  METHODS
  Fifteen patients who required double extraction of contralateral premolars and delayed implant placement were randomly selected to receive both ridge-preservation procedure and EXT. The test sites (alveolar ridge preservation [ARP]) included 15 sockets treated using a corticocancellous porcine bone xenograft (OsteoBiol® Gen-Os; Tecnoss srl, Giaveno, Italy) associated with a soft cortical membrane (OsteoBiol® Lamina; Tecnoss srl), while the corresponding control sites (EXT) were left without grafting for EXT. Horizontal and vertical ridge dimensions were recorded at baseline and 6 months after extractions.
  
  
  RESULTS
  After 6 months, the EXT sites showed a significantly greater reabsorption of the buccolingual/palatal dimension of the alveolar ridge (3.7 ± 1.2 mm) compared with the ARP sites (1.8 ± 1.3 mm). The mean vertical ridge height reduction in the control sockets was 3.1 ± 1.3 mm at the buccal sites and 2.4 ± 1.6 mm at the lingual sites compared with 0.6 ± 1.4 and 0.5 ± 1.3 mm, respectively, in the test sockets. The differences between test and control sockets were not significant for the mesial and distal measurements.
  
  
  CONCLUSIONS
  The placement of a porcine xenograft with a membrane in an extraction socket can be used to reduce the hard tissue reabsorption after tooth extraction compared with EXT.
authors.affiliation: Resident of oral and maxillofacial surgery, Stomatology Department, Second University of Naples (SUN), Naples, Italy; PhD in stomatology, Stomatology Department, Second University of Naples (SUN), Naples, Italy; associate professor of oral and maxillofacial surgery, Stomatology Department, Second University of Naples (SUN), Naples, Italy.
authors.forename: Vincenzo Maria
authors.initials: VM
authors.lastname: Festa
authors.forename: Francesco
authors.initials: F
authors.lastname: Addabbo
authors.forename: Luigi
authors.initials: L
authors.lastname: Laino
authors.forename: Felice
authors.initials: F
authors.lastname: Femiano
authors.forename: Rosario
authors.initials: R
authors.lastname: Rullo
mesh_terms: D000328:Adult; D000818:Animals; D015921:Dental Implants; D005260:Female; D064593:Heterografts; D006801:Humans; D008297:Male; D008875:Middle Aged; D013552:Swine; D014081:Tooth Extraction
chemical_list: D015921:Dental Implants