title: Effects of continuous haemofiltration on serum enzyme concentrations, endotoxemia, homeostasis and survival in dogs with severe heat stroke.
abstract: OBJECTIVE
  To examine the effectiveness of continuous haemofiltration as a treatment for severe heat stroke in dogs.
  
  
  METHODS
  Dogs were randomly allocated to a control or continuous haemofiltration group (both n=8). Heat stroke was induced by placing anaesthetised dogs in a high temperature cabin simulator. Upon confirmation of heat stroke (rectal temperature>42 °C, mean arterial pressure (MAP) decrease>25 mmHg), dogs were removed from the chamber and continuous haemofiltration was initiated and continued for 3h for dogs in the continuous haemofiltration group. Dogs in the control group were observed at room temperature.
  
  
  RESULTS
  Rectal temperature, haemodynamics, pH, blood gases and electrolyte concentrations rapidly returned to baseline in the continuous haemofiltration group, but not the control group. After 3h, rectal temperature was 36.68±0.51 °C in the continuous haemofiltration group and 39.83±1.10 °C in the control group (P<0.05). Continuous haemofiltration prevented endotoxin and all serum enzyme concentrations from increasing and caused malondialdehyde concentrations to decrease. After 3h, endotoxin concentrations were 0.14±0.02 EU ml(-1) in the continuous haemofiltration group and 0.23±0.05 EU ml(-1) in the control group (P=0.003), while malondialdehyde concentrations were 4.86±0.61 mmol l(-1) in the continuous haemofiltration group and 8.63±0.66 mmol l(-1) in the control group (P<0.001). Five dogs died in the control group within 3h, whereas no dogs died in the continuous haemofiltration group.
  
  
  CONCLUSIONS
  Continuous haemofiltration rapidly reduced body temperature, normalised haemodynamics and electrolytes, improved serum enzyme concentrations and increased survival in dogs with heat stroke. Continuous haemofiltration may be an effective treatment for heat stroke.
authors.affiliation: Fuzhou General Hospital, Nanjing Military Command, Fuzhou 350025, China.
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Chen
authors.forename: Hui-na
authors.initials: HN
authors.lastname: Xu
authors.forename: Li-fang
authors.initials: LF
authors.lastname: Gao
authors.forename: Jin-fu
authors.initials: JF
authors.lastname: Lu
authors.forename: Wen-rui
authors.initials: WR
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D001831:Body Temperature; D004285:Dogs; D004573:Electrolytes; D019446:Endotoxemia / Q000097:blood*; D004798:Enzymes / Q000097:blood*; D006339:Heart Rate; D018883:Heat Stroke / Q000628:therapy*; D006439:Hemodynamics; D006440:Hemofiltration / Q000379:methods*; D006487:Hemostasis; D056152:Respiratory Rate; D015996:Survival Rate
chemical_list: D004573:Electrolytes; D004798:Enzymes