title: Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  The purpose of this study was to quantify the effect of coenzyme Q10 on arterial endothelial function in patients with and without established cardiovascular disease.
  
  
  BACKGROUND
  Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis.
  
  
  RESULTS
  The search included MEDLINE, Cochrane Library, Scopus, and EMBASE to identify studies up to 1 July 2011. Eligible studies were randomized controlled trials on the effects of coenzyme Q10 compared with placebo on endothelial function. Two reviewers extracted data on study characteristics, methods, and outcomes. Five eligible trials enrolled a total of 194 patients. Meta-analysis using random-effects model showed treatment with coenzyme Q10 significantly improvement in endothelial function assessed peripherally by flow-mediated dilatation (SMD 1.70, 95% CI: 1.00-2.4, p<0.0001). However, the endothelial function assessed peripherally by nitrate-mediated arterial dilatation was not significantly improved by using fix-effects model (SMD -0.19, 95% CI: -1.75 to 1.38, p = 0.81).
  
  
  CONCLUSIONS
  Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction.
authors.affiliation: Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
authors.forename: Linggen
authors.initials: L
authors.lastname: Gao
authors.forename: Qunxia
authors.initials: Q
authors.lastname: Mao
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Yutang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014451:Ubiquinone / Q000627:therapeutic use*; D014652:Vascular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects
chemical_list: D002317:Cardiovascular Agents; D014451:Ubiquinone