title: Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information.
abstract: Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.
authors.forename: Teresa
authors.initials: T
authors.lastname: Correia
authors.forename: Juan
authors.initials: J
authors.lastname: Aguirre
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sisniega
authors.forename: Judit
authors.initials: J
authors.lastname: Chamorro-Servent
authors.forename: Juan
authors.initials: J
authors.lastname: Abascal
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Vaquero
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Ville
authors.initials: V
authors.lastname: Kolehmainen
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
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