title: Short-time scale dynamics in the responses to multiple stimuli in visual cortex.
abstract: Many previous studies have used the presentation of multiple stimuli in the receptive fields (RFs) of visual cortical neurons to explore how neurons might operate on multiple inputs. Most of these experiments have used two fixed stimulus locations within the RF of each neuron. Here the effects of using different positions within the RF of a neuron were explored. The stimuli were presented singly at one of six locations, and also at 15 pair-wise combinations, for 24 V2 cortical neurons in two macaque monkeys. There was considerable variability in how pairs of stimuli interacted within the receptive field of any given neuron: changing the position of the stimuli could result in enhancement, winner-take-all, or suppression relative to the strongest response to a stimulus presented by itself. Across the population of neurons there was no correlation between response strength and response latency. However, for many stimulus pairs the response latency was tightly locked to the shortest response latency of any single stimulus presented by itself independent of changes in response magnitude. In other words, a stimulus that by itself elicited a relatively long latency response, would often affect the magnitude of the response to a pair of stimuli, but not change the latency. These results may provide constraints on the development of models of cortical information processing.
authors.affiliation: Department of Vision Sciences, University of Alabama at Birmingham Birmingham, AL, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Gawne
references.citation: J Neurophysiol. 2001 Mar;85(3):1039-50
references.pmid: 11247974
references.citation: J Neurosci. 2007 Sep 5;27(36):9638-48
references.pmid: 17804624
references.citation: Vision Res. 1973 Apr;13(4):837-53
references.pmid: 4706354
references.citation: J Neurophysiol. 1996 Aug;76(2):1356-60
references.pmid: 8871243
references.citation: Vision Res. 2002 Oct;42(23):2593-615
references.pmid: 12446033
references.citation: Neuron. 2009 Apr 30;62(2):281-90
references.pmid: 19409272
references.citation: J Neurosci. 2007 Sep 5;27(36):9632-7
references.pmid: 17804623
references.citation: Neuron. 2002 Dec 5;36(5):791-804
references.pmid: 12467584
references.citation: Neurosci Lett. 2008 Apr 25;435(3):198-203
references.pmid: 18355960
references.citation: J Neurosci. 2005 Sep 7;25(36):8150-64
references.pmid: 16148223
references.citation: Biol Cybern. 1980;36(4):193-202
references.pmid: 7370364
references.citation: J Neurophysiol. 2004 Jun;91(6):2607-27
references.pmid: 14960559
references.citation: Science. 1994 May 27;264(5163):1333-6
references.pmid: 8191289
references.citation: J Neurophysiol. 2011 Mar;105(3):1150-8
references.pmid: 21177995
references.citation: Exp Brain Res. 1989;77(1):23-30
references.pmid: 2792266
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20961-6
references.pmid: 18087046
references.citation: Proc Natl Acad Sci U S A. 1987 Sep;84(17):6297-301
references.pmid: 3114747
references.citation: J Neurophysiol. 2002 Sep;88(3):1128-35
references.pmid: 12205134
references.citation: J Comput Neurosci. 2010 Dec;29(3):615-23
references.pmid: 20180148
references.citation: Nat Neurosci. 2003 Jan;6(1):59-65
references.pmid: 12469131
references.citation: Curr Opin Neurobiol. 1991 Aug;1(2):274-8
references.pmid: 1821190
references.citation: Nature. 1996 Jun 6;381(6582):520-2
references.pmid: 8632824
references.citation: Adv Cogn Psychol. 2008 Jul 15;3(1-2):167-76
references.pmid: 20517506
references.citation: Trends Neurosci. 2000 Nov;23(11):571-9
references.pmid: 11074267
references.citation: Perception. 1997;26(9):1169-80
references.pmid: 9509151
references.citation: J Neurophysiol. 2002 Nov;88(5):2178-86
references.pmid: 12424259
references.citation: Proc R Soc Lond B Biol Sci. 1979 May 23;204(1156):301-28
references.pmid: 37518
references.citation: Nat Neurosci. 1999 Nov;2(11):1019-25
references.pmid: 10526343
references.citation: J Neurosci. 1999 Mar 1;19(5):1736-53
references.pmid: 10024360
references.citation: Vis Neurosci. 1995 Nov-Dec;12(6):1191-210
references.pmid: 8962836
references.citation: J Neurosci. 2002 Mar 1;22(5):1976-84
references.pmid: 11880528
references.citation: J Neurophysiol. 2004 Nov;92(5):2704-13
references.pmid: 15269230
references.citation: J Neurophysiol. 1997 Jan;77(1):24-42
references.pmid: 9120566
references.citation: Science. 1985 Aug 23;229(4715):782-4
references.pmid: 4023713
references.citation: Neural Netw. 2001 Jul-Sep;14(6-7):795-803
references.pmid: 11665771
references.citation: Brain Res Brain Res Rev. 2001 Oct;36(2-3):96-107
references.pmid: 11690606
references.citation: J Neurophysiol. 2002 Dec;88(6):3398-408
references.pmid: 12466456
references.citation: J Neurosci. 2008 May 7;28(19):5115-26
references.pmid: 18463265
references.citation: J Neurosci. 2003 Jan 1;23(1):339-48
references.pmid: 12514233
references.citation: Neuron. 2003 Mar 6;37(5):853-63
references.pmid: 12628175