title: Armenin and isoarmenin--two prenylated coumarins from the aerial parts of Artemisia armeniaca.
abstract: The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of Artemisia armeniaca yielded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin), lacarol, and deoxylacarol, together with five other compounds, including three flavonoid glycosides, quercetin 3-O-β-D-glucopyranoside, rutin, and kaempferol 3-O-β-D-glucopyranoside, and chlorogenic acid, and tryptophan. (10E,12Z)-9-Hydroxyoctadeca-10,12-dienoic acid (β-dimorphecolic acid) was isolated from the CH(2)Cl(2) extract. Armenin and isoarmenin were new coumarins. Structures of all compounds were determined by spectroscopic means, including UV, MS, 1D- and 2D-NMR. The in vitro free-radical-scavenging property of the extracts and isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Mojarrab
authors.forename: Abbas
authors.initials: A
authors.lastname: Delazar
authors.forename: Sadeighe Bamdad
authors.initials: SB
authors.lastname: Moghadam
authors.forename: Hossein
authors.initials: H
authors.lastname: Nazemiyeh
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
authors.forename: Yashodharan
authors.initials: Y
authors.lastname: Kumarasamy
authors.forename: Solmaz
authors.initials: S
authors.lastname: Asnaashari
authors.forename: Abbas
authors.initials: A
authors.lastname: Hadjiakhoondi
authors.forename: Satyajit Dey
authors.initials: SD
authors.lastname: Sarker
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D007536:Isomerism; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D054876:Prenylation
chemical_list: D001713:Biphenyl Compounds; D003374:Coumarins; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; C572115:armenin; C004931:1,1-diphenyl-2-picrylhydrazyl