title: Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors.
abstract: Cancer cachexia is a multifaceted syndrome whose aetiology is extremely complex and is directly related to poor patient prognosis and survival. Changes in lipid metabolism in cancer cachexia result in marked reduction of total fat mass, increased lipolysis, total oxidation of fatty acids, hyperlipidaemia, hypertriglyceridaemia, and hypercholesterolaemia. These changes are believed to be induced by inflammatory mediators, such as tumour necrosis factor-α (TNF-α) and other factors. Attention has recently been drawn to the current theory that cachexia is a chronic inflammatory state, mainly caused by the host's reaction to the tumour. Changes in expression of numerous inflammatory mediators, notably in white adipose tissue (WAT), may trigger several changes in WAT homeostasis. The inhibition of adipocyte differentiation by PPARγ is paralleled by the appearance of smaller adipocytes, which may partially account for the inhibitory effect of PPARγ on inflammatory gene expression. Furthermore, inflammatory modulation and/or inhibition seems to be dependent on the IKK/NF-κB pathway, suggesting that a possible interaction between NF-κB and PPARγ is required to modulate WAT inflammation induced by cancer cachexia. In this article, current literature on the possible mechanisms of NF-κB and PPARγ regulation of WAT cells during cancer cachexia are discussed. This review aims to assess the role of a possible interaction between NF-κB and PPARγ in the setting of cancer cachexia as well as its significant role as a potential modulator of chronic inflammation that could be explored therapeutically.
authors.affiliation: Laboratory of Adipose Tissue Biology, Center for Integrated Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, Sao Paulo, Brazil. miguelj@umc.br
authors.forename: M L
authors.initials: ML
authors.lastname: Batista
authors.forename: S B
authors.initials: SB
authors.lastname: Peres
authors.forename: M E
authors.initials: ME
authors.lastname: McDonald
authors.forename: P S M
authors.initials: PS
authors.lastname: Alcantara
authors.forename: M
authors.initials: M
authors.lastname: Olivan
authors.forename: J P
authors.initials: JP
authors.lastname: Otoch
authors.forename: S R
authors.initials: SR
authors.lastname: Farmer
authors.forename: M
authors.initials: M
authors.lastname: Seelaender
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D002100:Cachexia / Q000150:complications* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology; D009369:Neoplasms / Q000150:complications* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors