title: High expression of CCL20 is associated with poor prognosis in patients with hepatocellular carcinoma after curative resection.
abstract: BACKGROUND
  Chemokine ligand 20 (CCL20) plays an important role in the carcinogenesis, invasion, and progression of malignancies. This study aimed to investigate the prognostic significance of CCL20 in patients with hepatocellular carcinoma (HCC) after curative resection.
  
  
  METHODS
  Expression of CCL20 was evaluated by immunohistochemistry in tumor tissue from 125 patients who underwent curative resection of HCC. The relationship between CCL20 expression and clinicopathologic features was analyzed. Univariate and multivariate analyses were performed to evaluate its predictive value for tumor recurrence and survival of HCC patients.
  
  
  RESULTS
  CCL20 expression was verified in all tumor specimens. CCL20 expression was associated with tumor size (P = 0.002), tumor number (P = 0.031), vascular invasion (P = 0.003), tumor differentiation (P = 0.024), and tumor recurrence (P < 0.001). Patients with high CCL20 expression had poorer recurrence-free survival and overall survival (both P < 0.001) than those with low CCL20 expression. Multivariate analysis showed CCL20 expression was an independent predictor of tumor recurrence (Hazard ratio 3.934, P = 0.002), recurrence-free survival (Hazard ratio 2.573, P = 0.001), and overall survival (Hazard ratio 2.930, P = 0.001).
  
  
  CONCLUSIONS
  CCL20 expression was associated with tumor recurrence and survival of HCC patients. It may be used to predict prognosis of patients with HCC and may be a new target of postoperative adjuvant therapy.
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
authors.forename: Xiangjiu
authors.initials: X
authors.lastname: Ding
authors.forename: Kexin
authors.initials: K
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Guangyong
authors.initials: G
authors.lastname: Zhang
authors.forename: Yajing
authors.initials: Y
authors.lastname: Liu
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Yang
authors.forename: Weijie
authors.initials: W
authors.lastname: Chen
authors.forename: Sanyuan
authors.initials: S
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D054418:Chemokine CCL20 / Q000378:metabolism*; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C108355:CCL20 protein, human; D054418:Chemokine CCL20
references.citation: Arch Oral Biol. 2003 Feb;48(2):171-5
references.pmid: 12642237
references.citation: World J Gastroenterol. 2006 Nov 7;12(41):6627-33
references.pmid: 17075975
references.citation: Lung Cancer. 2008 Jun;60(3):401-7
references.pmid: 18036700
references.citation: BMC Cancer. 2009 Dec 01;9:418
references.pmid: 19948069
references.citation: J Am Coll Surg. 2006 Feb;202(2):275-83
references.pmid: 16427553
references.citation: J Clin Oncol. 2007 Jun 20;25(18):2586-93
references.pmid: 17577038
references.citation: Int J Cancer. 2009 Aug 15;125(4):741-5
references.pmid: 19480006
references.citation: PLoS One. 2011 Apr 29;6(4):e19495
references.pmid: 21559338
references.citation: Mol Cell Endocrinol. 2011 Jan 1;331(1):129-35
references.pmid: 20816914
references.citation: J Clin Invest. 2000 May;105(10):1383-93
references.pmid: 10811846
references.citation: J Gastrointest Surg. 2011 Feb;15(2):321-9
references.pmid: 21061181
references.citation: J Transl Med. 2010 May 10;8:45
references.pmid: 20459729
references.citation: CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
references.pmid: 17237035
references.citation: Clin Cancer Res. 2010 Nov 15;16(22):5529-38
references.pmid: 20889918
references.citation: J Cancer Res Clin Oncol. 2008 Nov;134(11):1181-9
references.pmid: 18465142
references.citation: Scand J Immunol. 2006 Jun;63(6):468-77
references.pmid: 16764701
references.citation: Eur J Cancer. 2010 Jun;46(9):1712-23
references.pmid: 20435467
references.citation: Int J Cancer. 1999 May 17;81(4):650-7
references.pmid: 10225458
references.citation: Adv Drug Deliv Rev. 2006 Oct 1;58(8):962-74
references.pmid: 16996642
references.citation: Ann Surg. 2011 Oct;254(4):569-76
references.pmid: 21892074
references.citation: Immunity. 2000 Feb;12(2):121-7
references.pmid: 10714678
references.citation: Biochem Biophys Res Commun. 2004 Sep 24;322(3):1052-8
references.pmid: 15336571
references.citation: J Biol Chem. 1997 Feb 28;272(9):5846-53
references.pmid: 9038201
references.citation: Surgery. 2007 Feb;141(2):196-202
references.pmid: 17263976
references.citation: Clin Cancer Res. 2008 Nov 1;14(21):6979-87
references.pmid: 18980993
references.citation: Int J Mol Med. 2003 May;11(5):601-5
references.pmid: 12684696
references.citation: Lancet Oncol. 2001 Sep;2(9):533-43
references.pmid: 11905707
references.citation: Gastroenterology. 2007 Jun;132(7):2557-76
references.pmid: 17570226
references.citation: J Cell Biochem. 2006 Mar 1;97(4):709-23
references.pmid: 16215992
references.citation: J Gastrointest Surg. 2011 Jul;15(7):1205-12
references.pmid: 21562916
references.citation: J Immunol. 2004 Oct 15;173(8):4929-35
references.pmid: 15470034
references.citation: Hepatology. 2011 Feb;53(2):493-503
references.pmid: 21274871
references.citation: PLoS One. 2009;4(4):e5125
references.pmid: 19340288
references.citation: J Hepatol. 2007 Nov;47(5):684-90
references.pmid: 17854945
references.citation: Lancet. 2003 Dec 6;362(9399):1907-17
references.pmid: 14667750
references.citation: Gut. 2010 Dec;59(12):1699-708
references.pmid: 20940284