title: Anti-fatigue effect of Renshen Yangrong decoction in mice.
abstract: OBJECTIVE
  To explore the anti-fatigue effect of Renshen Yangrong Decoction (RYD): in mice.
  
  
  METHODS
  One hundred Kunming mice were randomly divided into 5 groups with 20 mice in each: group. The negative control group was treated with distilled water, the positive control group was treated with Shiyiwei Shenqi Tablet (, 1.0 g/kg), the high-, medium- and low-dose RYD groups were treated with 42.0, 21.0 and 10.5 g/kg of RYD daily, respectively, by gastric infusion. At the end of the 7-day treatment, loaded swimming time, organ wet weight and coefficient, serum glucose, urea nitrogen, and hepatic glycogen levels were determined. The outcomes were compared among groups.
  
  
  RESULTS
  As compared with the negative: control group, the loaded swimming time was significantly increased in the positive control group, specifically the medium- and high-dose RYD groups (P<0.01). In addition, the wet weights and coefficients of the spleen and thymus, and the serum glucose and hepatic glycogen contents were increased, whereas serum urea nitrogen level was significantly decreased in the positive control group and the high dose RYD group (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  RYD showed an anti-fatigue effect in mice.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China.
authors.forename: Yan-zhi
authors.initials: YZ
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Lin
authors.forename: Ping-ping
authors.initials: PP
authors.lastname: Li
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005221:Fatigue / Q000097:blood / Q000188:drug therapy*; D018698:Glutamic Acid / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013550:Swimming; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; C570747:renshen yangrong decoction; D018698:Glutamic Acid; D006003:Glycogen
references.citation: Lancet. 2003 Aug 23;362(9384):640-50
references.pmid: 12944066
references.citation: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:30-3
references.pmid: 17569340
references.citation: Chin J Integr Med. 2011 Jun;17(6):453-8
references.pmid: 21465297
references.citation: Psychoneuroendocrinology. 2006 Nov;31(10):1231-44
references.pmid: 17081700
references.citation: Cancer. 2003 Nov 1;98(9):1786-801
references.pmid: 14584059
references.citation: Brain Behav Immun. 2007 May;21(4):413-27
references.pmid: 17178209