title: Left atrial volume predicts adverse cardiac and cerebrovascular events in patients with hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  To prospectively evaluate the relationship between left atrial volume (LAV) and the risk of clinical events in patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  We enrolled a total of 141 HCM patients with sinus rhythm and normal pump function, and 102 patients (73 men; mean age, 61±13 years) who met inclusion criteria were followed for 30.8±10.0 months. The patients were divided into two groups with or without major adverse cardiac and cerebrovascular events (MACCE), a composite of stroke, sudden death, and congestive heart failure. Detailed clinical and echocardiographic data were obtained.
  
  
  RESULTS
  MACCE occurred in 24 patients (18 strokes, 4 congestive heart failure and 2 sudden deaths). Maximum LAV, minimum LAV, and LAV index (LAVI) corrected for body surface area (BSA) were significantly greater in patients with MACCE than those without MACCE (maximum LAV: 64.3±25.0 vs. 51.9±16.0 ml, p=0.005; minimum LAV: 33.9±15.1 vs. 26.2±10.9 ml, p=0.008; LAVI: 40.1±15.4 vs. 31.5±8.7 ml/mm2, p=0.0009), while there were no differences in the other echocardiographic parameters.LAV/BSA of ≥40.4 ml/m2 to identify patients with cardiovascular complications with a sensitivity of 73% and a specificity of 88%.
  
  
  CONCLUSIONS
  LAVI may be an effective marker for detecting the risk of MACCE in patients with HCM and normal pump function.
authors.affiliation: Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. tomokot@kcho.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tani
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitai
authors.forename: Kitae
authors.initials: K
authors.lastname: Kim
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Konda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii
authors.forename: Junichi
authors.initials: J
authors.lastname: Kawai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kobori
authors.forename: Natsuhiko
authors.initials: N
authors.lastname: Ehara
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Kaji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamuro
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Morioka
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Furukawa
mesh_terms: D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D015897:Comorbidity; D004452:Echocardiography / Q000706:statistics & numerical data; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
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