title: Insights into immunophilin structure and function.
abstract: The immunophilins are proteins which are capable of influencing the immune response in combination with an immunosuppressive drug. Their natural function, however, is mainly the cis/trans isomerization of peptidyl-prolyl bonds in other proteins. This review lists all immunophilin structure coordinates currently available in the RCSB protein data bank and highlights the key active-site factors that define their catalytic and immunological action. In addition, an overview of biologically-relevant functions is provided for various immunophilin members.
authors.affiliation: Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle (Saale), Germany. luecke@enzyme-halle.mpg.de
authors.forename: C
authors.initials: C
authors.lastname: Lücke
authors.forename: M
authors.initials: M
authors.lastname: Weiwad
mesh_terms: D000818:Animals; D055162:Biocatalysis; D020134:Catalytic Domain; D030562:Databases, Protein; D006801:Humans; D020104:Immunophilins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D007536:Isomerism
chemical_list: D007166:Immunosuppressive Agents; D020104:Immunophilins