title: Potential Agents against Plasma Leakage.
abstract: Shock due to severe plasma leakage may happen in infectious diseases such as severe dengue and sepsis due to various bacterial infections, which may be deleterious and may lead to death. Various substances and proteins are known to modulate the effects of proleakage mediators and counteract the deleterious effect of plasma leakage. Some of the various substances and proteins such as focal adhesion kinase (FAK), the Rho GTPases, protein kinase A, and caveolin-1 have dual actions; therefore they are not suitable for therapy. However, sphingosine 1phosphate and its receptor agonists, Angiopoetin-1, Slit, and Bbeta15-42 may be promising.
authors.affiliation: Department of Histology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta 10430, Indonesia.
authors.forename: Jeanne Adiwinata
authors.initials: JA
authors.lastname: Pawitan
references.citation: J Biol Chem. 2003 May 23;278(21):19023-31
references.pmid: 12654918
references.citation: J Physiol. 2005 Dec 1;569(Pt 2):359-66
references.pmid: 16195317
references.citation: Exp Cell Res. 2007 Sep 10;313(15):3285-97
references.pmid: 17686471
references.citation: Cancer Res. 2002 Oct 1;62(19):5580-9
references.pmid: 12359771
references.citation: Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L258-67
references.pmid: 12626332
references.citation: Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2332-9
references.pmid: 17761936
references.citation: Physiol Rev. 2006 Jan;86(1):279-367
references.pmid: 16371600
references.citation: Nat Med. 2008 Apr;14(4):448-53
references.pmid: 18345009
references.citation: J Cell Sci. 2000 Feb;113 ( Pt 3):471-82
references.pmid: 10639334
references.citation: J Biol Chem. 2002 Oct 18;277(42):40091-8
references.pmid: 12167625
references.citation: Shock. 2007 Dec;28(6):650-654
references.pmid: 18092380
references.citation: J Biol Chem. 2003 Jul 4;278(27):24865-73
references.pmid: 12702722
references.citation: Cancer Biol Ther. 2009 Dec;8(23):2286-96
references.pmid: 19923922
references.citation: J Biol Chem. 2003 Nov 21;278(47):47281-90
references.pmid: 12954648
references.citation: Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L972-80
references.pmid: 12588708
references.citation: Nat Cell Biol. 2006 Nov;8(11):1223-34
references.pmid: 17060906
references.citation: Nat Cell Biol. 2009 Nov;11(11):1325-31
references.pmid: 19855388
references.citation: Curr Biol. 2000 Jun 15;10(12):719-22
references.pmid: 10873807
references.citation: Biochem Soc Trans. 2003 Dec;31(Pt 6):1216-9
references.pmid: 14641029
references.citation: J Biochem. 2003 Sep;134(3):309-13
references.pmid: 14561714
references.citation: J Clin Invest. 2009 Jul;119(7):1871-9
references.pmid: 19603543
references.citation: Nat Rev Mol Cell Biol. 2001 Nov;2(11):793-805
references.pmid: 11715046
references.citation: J Physiol. 2002 Mar 15;539(Pt 3):779-89
references.pmid: 11897849
references.citation: Curr Opin Investig Drugs. 2009 Sep;10(9):997-1003
references.pmid: 19705343
references.citation: Circ Res. 2001 Sep 14;89(6):477-9
references.pmid: 11557733
references.citation: Mol Cell Biol. 2004 May;24(9):3849-59
references.pmid: 15082779
references.citation: Circ Res. 2004 Jul 23;95(2):196-203
references.pmid: 15192021
references.citation: N Engl J Med. 2010 Aug 12;363(7):689-91
references.pmid: 20818861
references.citation: Sci Transl Med. 2010 Mar 17;2(23):23ra19
references.pmid: 20375003
references.citation: Biochem J. 2004 May 15;380(Pt 1):1-17
references.pmid: 15040784
references.citation: Thorax. 2008 Oct;63(10):903-9
references.pmid: 18559364
references.citation: Blood. 2005 Mar 1;105(5):1950-5
references.pmid: 15374886
references.citation: PLoS One. 2009;4(4):e5391
references.pmid: 19401765
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H107-18
references.pmid: 16126815
references.citation: Circ Res. 2000 Sep 29;87(7):603-7
references.pmid: 11009566
references.citation: Trends Cell Biol. 2004 Jun;14(6):303-11
references.pmid: 15183187
references.citation: J Biol Chem. 2003 Apr 18;278(16):13615-8
references.pmid: 12606561
references.citation: J Clin Invest. 2001 Sep;108(5):689-701
references.pmid: 11544274
references.citation: Curr Opin Cell Biol. 2001 Apr;13(2):153-7
references.pmid: 11248548
references.citation: Br J Pharmacol. 2003 May;139(2):329-36
references.pmid: 12770938
references.citation: Crit Care Med. 2007 Jul;35(7):1730-5
references.pmid: 17522584
references.citation: FASEB J. 2003 Dec;17(15):2240-9
references.pmid: 14656986
references.citation: Circ Res. 2004 Feb 6;94(2):159-66
references.pmid: 14656933
references.citation: J Biol Chem. 2000 Jun 16;275(24):18366-74
references.pmid: 10748018
references.citation: J Appl Physiol (1985). 2003 Mar;94(3):1193-203
references.pmid: 12482769
references.citation: J Biol Chem. 2003 Apr 11;278(15):13265-70
references.pmid: 12551902
references.citation: Vascul Pharmacol. 2002 Nov;39(4-5):187-99
references.pmid: 12747959