title: The Goldilocks principle and antibiotic resistance in bacteria.
abstract: We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in microecology if bacteria have already acquired the phenotype of growth advantage at the stationary phase (GASP).
authors.affiliation: Department of Physics, Princeton University, Princeton, New Jersey 08544, United States.
authors.forename: Qiucen
authors.initials: Q
authors.lastname: Zhang
authors.forename: Kristelle
authors.initials: K
authors.lastname: Robin
authors.forename: David
authors.initials: D
authors.lastname: Liao
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lambert
authors.forename: Robert H
authors.initials: RH
authors.lastname: Austin
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D060833:Cellular Microenvironment / Q000502:physiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D019143:Evolution, Molecular
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin
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