title: A systematic review comparing hysterectomy with less-invasive treatments for abnormal uterine bleeding.
abstract: OBJECTIVE
  To compare hysterectomy with less-invasive alternatives for abnormal uterine bleeding (AUB) in 7 clinically important domains.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Randomized clinical trials comparing bleeding, quality of life, pain, sexual health, satisfaction, need for subsequent surgery, and adverse events between hysterectomy and less-invasive treatment options.
  
  
  METHODS
  Women with AUB, predominantly from ovulatory disorders and endometrial causes.
  
  
  METHODS
  Systematic review of the literature (from inception to January 2011) comparing hysterectomy with alternatives for AUB treatment. Eligible trials were extracted into standardized forms. Trials were graded with a predefined 3-level rating, and the strengths of evidence for each outcome were evaluated with the Grades for Recommendation, Assessment, Development and Evaluation system.
  
  
  RESULTS
  Nine randomized clinical trials (18 articles) were eligible. Endometrial ablation, levonorgestrel intrauterine system, and medications were associated with lower risk of adverse events but higher risk of additional treatments than hysterectomy. Compared to ablation, hysterectomy had superior long-term pain and bleeding control. Compared with the levonorgestrel intrauterine system, hysterectomy had superior control of bleeding. No other differences between treatments were found.
  
  
  CONCLUSIONS
  Less-invasive treatment options for AUB result in improvement in quality of life but carry significant risk of retreatment caused by unsatisfactory results. Although hysterectomy is the most effective treatment for AUB, it carries the highest risk for adverse events.
authors.affiliation: Women and Infants Hospital, Providence, Rhode Island, USA.
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Matteson
authors.forename: Husam
authors.initials: H
authors.lastname: Abed
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Wheeler
authors.forename: Vivian W
authors.initials: VW
authors.lastname: Sung
authors.forename: David D
authors.initials: DD
authors.lastname: Rahn
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Schaffer
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Balk
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D003271:Contraceptive Agents, Female / Q000627:therapeutic use*; D055356:Endometrial Ablation Techniques / Q000009:adverse effects; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007436:Intrauterine Devices, Medicated / Q000009:adverse effects; D016912:Levonorgestrel / Q000627:therapeutic use*; D011788:Quality of Life; D012725:Sexual Behavior; D014592:Uterine Hemorrhage / Q000601:surgery / Q000628:therapy*
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel
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