title: A surprisingly singular role for endophilin in synaptic vesicle recycling.
abstract: Synaptic vesicle endocytosis requires membrane curvature, fission, and uncoating. Endophilin has been proposed to play a role in all three steps, but in this issue of Neuron, De Camilli and colleagues show that at mammalian central synapses it is primarily involved in clathrin uncoating.
authors.affiliation: Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA. jmsull@uw.edu
authors.forename: Jane M
authors.initials: JM
authors.lastname: Sullivan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002966:Clathrin; D047908:Intracellular Signaling Peptides and Proteins; C498434:Sh3gl2 protein, mouse; C528010:endophilin II, mouse