title: Pulmonary tumor thrombotic microangiopathy associated with esophageal squamous cell carcinoma.
abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication that has been most frequently reported to be associated with adenocarcinoma. We present a case of PTTM which developed in a 60-year-old man with esophageal carcinoma. One year after definitive treatment of the tumor, he developed pulmonary hypertension. Transbronchial lung biopsy (TBLB) specimens showed fibrocellular intimal proliferation and luminal stenosis of the small pulmonary vessels, which contained squamous cell carcinoma cells. Thus, PTTM associated with esophageal carcinoma was diagnosed. This is the first reported case of PTTM associated with esophageal squamous cell carcinoma. TBLB seemed to be useful for obtaining a definitive diagnosis.
authors.affiliation: Department of Gastroenterology and Gastrointestional Oncology, National Cancer Center Hospital East, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
authors.forename: Nozomu
authors.initials: N
authors.lastname: Fuse
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.forename: Takahide
authors.initials: T
authors.lastname: Sasaki
authors.forename: Junko
authors.initials: J
authors.lastname: Sugiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yoshino
authors.forename: Makoto
authors.initials: M
authors.lastname: Tahara
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Doi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtsu
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D004938:Esophageal Neoplasms / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008175:Lung Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D057049:Thrombotic Microangiopathies / Q000150:complications* / Q000175:diagnosis