title: Accelerated phase-contrast cine MRI using k-t SPARSE-SENSE.
abstract: Phase-contrast (PC) cine MRI is a promising method for assessment of pathologic hemodynamics, including cardiovascular and hepatoportal vascular dynamics, but its low data acquisition efficiency limits the achievable spatial and temporal resolutions within clinically acceptable breath-hold durations. We propose to accelerate PC cine MRI using an approach which combines compressed sensing and parallel imaging (k-t SPARSE-SENSE). We validated the proposed 6-fold accelerated PC cine MRI against 3-fold accelerated PC cine MRI with parallel imaging (generalized autocalibrating partially parallel acquisitions). With the programmable flow pump, we simulated a time varying waveform emulating hepatic blood flow. Normalized root mean square error between two sets of velocity measurements was 2.59%. In multiple blood vessels of 12 control subjects, two sets of mean velocity measurements were in good agreement (mean difference = -0.29 cm/s; lower and upper 95% limits of agreement = -5.26 and 4.67 cm/s, respectively). The mean phase noise, defined as the standard deviation of the phase in a homogeneous stationary region, was significantly lower for k-t SPARSE-SENSE than for generalized autocalibrating partially parallel acquisitions (0.05 ± 0.01 vs. 0.19 ± 0.06 radians, respectively; P < 0.01). The proposed 6-fold accelerated PC cine MRI pulse sequence with k-t SPARSE-SENSE is a promising investigational method for rapid velocity measurement with relatively high spatial (1.7 mm × 1.7 mm) and temporal (∼35 ms) resolutions.
authors.affiliation: Department of Radiology, New York University School of Medicine, New York, NY, USA. kimd10@nyumc.org
authors.forename: Daniel
authors.initials: D
authors.lastname: Kim
authors.forename: Hadrien A
authors.initials: HA
authors.lastname: Dyvorne
authors.forename: Ricardo
authors.initials: R
authors.lastname: Otazo
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Sodickson
authors.forename: Vivian S
authors.initials: VS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000465:Algorithms; D001783:Blood Flow Velocity; D055424:Cardiac-Gated Imaging Techniques; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000098:blood supply*; D019028:Magnetic Resonance Imaging, Cine / Q000295:instrumentation / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging
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