title: Application of activity-based protein profiling to the study of microbial pathogenesis.
abstract: Activity-based protein profiling (ABPP) is a powerful technology for the dissection of dynamic and complex enzyme interactions. The mechanisms involved in microbial pathogenesis are an example of just such a system, with a plethora of highly regulated enzymatic interactions between the infecting organism and its host. In this review we will discuss some of the cutting-edge applications of ABPP to the study of bacterial and parasitic pathogenesis and virulence, with an emphasis on Clostridium difficile, methicillin-resistant Staphylococcus aureus, quorum sensing, and malaria.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
authors.forename: William P
authors.initials: WP
authors.lastname: Heal
authors.forename: Edward W
authors.initials: EW
authors.lastname: Tate
mesh_terms: D001419:Bacteria / Q000472:pathogenicity*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D040081:Protein Array Analysis; D011506:Proteins / Q000737:chemistry*; D040901:Proteomics / Q000379:methods*; D053038:Quorum Sensing
chemical_list: D011506:Proteins