title: Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.
abstract: Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data. All compounds exhibited noticeable acaricidal and insecticidal activities. Especially compound 2 was found to be the most potent pesticide of the compounds evaluated with the IC(50) values of 10.2, 65.1 and 124.4 μg/ml against adult two-spotted spider mites (Tetranychus urticae Koch), two-spotted spider mite eggs, and Mythimna separata, respectively, which are comparable to those of commercial pesticide milbemycin A(3)/A(4) as positive reference.
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang, P R China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D040102:Tetranychidae / Q000187:drug effects / Q000254:growth & development
chemical_list: D056810:Acaricides; D007306:Insecticides; D007559:Ivermectin; C084101:doramectin