title: Three-component tandem reaction involving acid chlorides, terminal alkynes, and 2-aminoindole hydrochlorides: synthesis of α-carboline derivatives in aqueous conditions via regioselective [3 + 3] cyclocondensation.
abstract: An efficient synthesis toward highly diversified α-carboline derivatives via a three-component tandem reaction using acid chlorides, terminal alkynes, and 2-aminoindole hydrochlorides has been described. The salient feature of the one-pot strategy involves regioselective [3 + 3]-cyclocondensation and the presence of water in the reaction medium to facilitate cyclization. Nonaqueous conditions furnished products in poor yields.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226001, India.
authors.forename: Sahaj
authors.initials: S
authors.lastname: Gupta
authors.forename: Brijesh
authors.initials: B
authors.lastname: Kumar
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
mesh_terms: D000143:Acids / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002243:Carbolines / Q000138:chemical synthesis; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000143:Acids; D000480:Alkynes; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002243:Carbolines; D002712:Chlorides; D007211:Indoles; D014867:Water; C055571:alpha-carboline