title: Comparing the performance of QuantiFERON-TB Gold and Mantoux test in detecting latent tuberculosis infection among Iranian health care workers.
abstract: OBJECTIVE
  The risk of transmission of Mycobacterium tuberculosis from patients with tuberculosis to health care workers (HCWs) has been well documented but little is known about the prevalence of latent tuberculosis infection (LTBI) in Iranian HCWs. The aim of this study was to determine the prevalence of LTBI among HCWs by using IFNgamma-release assay and compare the results with those of tuberculin skin test (TST).
  
  
  METHODS
  Two hundred HCWs were evaluated with both TST and QuantiFERON-TB Gold In Tube test (QFT-GIT). The obtained data were analyzed by SPSS v.16 Software.
  
  
  RESULTS
  The participants were 73 males and 127 females with the mean age of 34.36±8.26 years. TST was positive in 105 cases (52.5%) and the QFT results were positive in 17 cases (8.5%). There was poor agreement between the two tests (53%, κ = 0.115). Induration diameter of TST ≥ 10 mm and working duration ≥ 10 years were independent predictors for positive QFT (p = 0.004).
  
  
  CONCLUSIONS
  Due to the fact that BCG vaccination has been administered routinely to all HCWs in Iran, specific tests should be introduced for high risk groups. QFT thus seems to be more effective for LTBI diagnosis than TST among HCWs with BCG immunization history.
authors.affiliation: Antimicrobial Resistance Research Center, Infectious Diseases Department, Tehran University of Medical Sciences, Tehran, Iran. m-talebitaher@tums.ac.ir
authors.forename: Mahshid
authors.initials: M
authors.lastname: Talebi-Taher
authors.forename: Seied-Ali
authors.initials: SA
authors.lastname: Javad-Moosavi
authors.forename: Amir-Hossein
authors.initials: AH
authors.lastname: Entezari
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shekarabi
authors.forename: Baran
authors.initials: B
authors.lastname: Parhizkar
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006282:Health Personnel; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D007492:Iran / Q000453:epidemiology; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D016273:Occupational Exposure; D011237:Predictive Value of Tests; D014374:Tuberculin Test / Q000592:standards*; D055815:Young Adult