title: Empowering international canine inherited disorder management.
abstract: The mapping of the canine genome and the study of canine breed genomic architecture has revolutionized the discovery of genetic tests for inherited disorders in dogs. As the genetics underlying complex disorders are revealed, canine breeders and their registering organisations will be required to understand genetics in a much more sophisticated way. To facilitate the management of genetic disorders in the era of new complex information, we consider how best to apply the results of new research and analytical techniques to benefit the wider canine breeding community with the aims of improving canine health and maintaining benevolent genetic diversity. If this is not done, there is a serious risk that expensive and valuable genetic research will remain unused or be misused to the detriment of breeds. In this review, we make a case for the formation of an international organisation that will exist as a central repository for breed-based genetic analysis and information sharing. This organisation ("Inter-Dog") could be modelled on a similar organisation that is monitoring genetic improvement of dairy cattle. The formation of such an organisation will require the collaboration of international kennel management organisations, researchers, and agencies offering genetic testing services.
authors.affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Bethany J
authors.initials: BJ
authors.lastname: Wilson
authors.forename: Claire M
authors.initials: CM
authors.lastname: Wade
mesh_terms: D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D005820:Genetic Testing / Q000662:veterinary*; D014644:Genetic Variation; D016678:Genome; D007391:International Cooperation
references.citation: Vet J. 2011 Aug;189(2):197-202
references.pmid: 21741865
references.citation: Vet J. 2009 Dec;182(3):402-11
references.pmid: 19836981
references.citation: Vet J. 2010 Jan;183(1):39-45
references.pmid: 19963415
references.citation: Vet J. 2010 Mar;183(3):243-4
references.pmid: 20042354
references.citation: Int J Immunogenet. 2006 Jun;33(3):179-84
references.pmid: 16712648
references.citation: J Am Vet Med Assoc. 2010 Sep 1;237(5):532-41
references.pmid: 20807130
references.citation: BMC Genet. 2011 Apr 25;12:38
references.pmid: 21518446
references.citation: Vet J. 2011 Aug;189(2):203-10
references.pmid: 21741282
references.citation: Osteoarthritis Cartilage. 2011 Apr;19(4):420-9
references.pmid: 21215318
references.citation: Nat Genet. 2010 Mar;42(3):250-4
references.pmid: 20101241
references.citation: Vet J. 2011 Aug;189(2):147-54
references.pmid: 21742521
references.citation: J Hered. 2007;98(5):518-25
references.pmid: 17611256
references.citation: Nat Genet. 2007 Nov;39(11):1321-8
references.pmid: 17906626
references.citation: J Dairy Sci. 2008 Nov;91(11):4116-28
references.pmid: 18946115
references.citation: Vet J. 2011 Aug;189(2):160-8
references.pmid: 21727013
references.citation: Vet Rec. 2011 Apr 16;168(15):414
references.pmid: 21498460
references.citation: J Vet Intern Med. 2006 Jan-Feb;20(1):131-5
references.pmid: 16496932
references.citation: Vet J. 2011 Aug;189(2):189-96
references.pmid: 21741866
references.citation: J Dairy Sci. 2009 Feb;92(2):433-43
references.pmid: 19164653
references.citation: Genome. 2010 Nov;53(11):876-83
references.pmid: 21076503
references.citation: Genet Sel Evol. 2011 Jan 20;43(1):4
references.pmid: 21251244
references.citation: J Am Vet Med Assoc. 2005 Feb 1;226(3):387-92
references.pmid: 15702688
references.citation: Vet J. 2011 Aug;189(2):132-5
references.pmid: 21737319