title: Full range characterization of the Raman spectra of organs in a murine model.
abstract: Raman spectroscopy is a minimally-invasive optical technique with great potential for in vivo cancer detection and disease diagnosis. However, there is no systematic study of the Raman spectra from different organs to date. We measured and characterized the Raman spectra eighteen naïve mouse organs in a broad frequency range of 700 to 3100 cm⁻¹. The peaks of generic proteins and lipids appeared in Raman spectra of all organs. Some organs like bone, teeth, brain and lung had unique Raman peaks. The autofluorescence was strong in liver, spleen, heart, and kidney. These results suggest that organ specific Raman probe design and specific data processing strategies are required in order to get the most useful information.
authors: Imaging Unit - Integrative Oncology Department, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver V5Z 1L3, BC, Canada.
authors: Naiyan
authors: N
authors: Huang
authors: Michael
authors: M
authors: Short
authors: Jianhua
authors: J
authors: Zhao
authors: Hequn
authors: H
authors: Wang
authors: Harvey
authors: H
authors: Lui
authors: Mladen
authors: M
authors: Korbelik
authors: Haishan
authors: H
authors: Zeng
mesh_terms: D000818:Animals; D005453:Fluorescence; D051379:Mice; D008809:Mice, Inbred C3H; D023421:Models, Animal; D009928:Organ Specificity; D044967:Serum / Q000378:metabolism; D013059:Spectrum Analysis, Raman / Q000379:methods*