title: [Clinical application of pain-related evoked potentials].
abstract: Pain-related evoked potentials (PREPs) represent a novel method for the evaluation of peripheral and central nociceptive pathways, e.g. in the diagnosis of small fiber neuropathy (SFN) or after therapeutic interventions for headache. Compared to contact heat-evoked and laser-evoked potentials, recording of PREPs is less stressful for the subjects and technically less demanding. The clinical usefulness of PREPs has been described for SFN associated with diabetes, HIV and hepatitis C infections as well as in headache and facial pain disorders. They have also been evaluated after interventional methods, such as direct current stimulation (tDCS). The article reviews and discusses the advantages and pitfalls of this technique in the context of recent clinical studies as compared to other paradigms of peripheral electrical stimulation and delineates perspectives and possible indications.
authors: Neurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Strasse 11, Würzburg, Germany. hansen_n@klinik.uni-wuerzburg.de
authors: N
authors: N
authors: Hansen
authors: M
authors: M
authors: Obermann
authors: N
authors: N
authors: Uçeyler
authors: D
authors: D
authors: Zeller
authors: D
authors: D
authors: Mueller
authors: M S
authors: MS
authors: Yoon
authors: K
authors: K
authors: Reiners
authors: C
authors: C
authors: Sommer
authors: Z
authors: Z
authors: Katsarava
mesh_terms: D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007834:Lasers; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology*; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology*; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000294:innervation; D013697:Thermosensing / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000700:Analgesics