title: Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
abstract: Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mechanisms have not been identified. This study is the first to identify an alteration in a regulatory protein which is known to promote both dendritic length and arborization in developing neurons, Kalirin-9. We found Kalirin-9 expression to be paradoxically increased in schizophrenia. We followed up this observation by overexpressing Kalirin-9 in mature primary neuronal cultures, causing reduced dendritic length and complexity. Kalirin-9 overexpression represents a potential mechanism for dendritic changes seen in schizophrenia.
authors: Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors: Anthony J
authors: AJ
authors: Deo
authors: Michael E
authors: ME
authors: Cahill
authors: Siyu
authors: S
authors: Li
authors: Isaac
authors: I
authors: Goldszer
authors: Ruth
authors: R
authors: Henteleff
authors: Jon-Eric
authors: JE
authors: Vanleeuwen
authors: Igor
authors: I
authors: Rafalovich
authors: Ruoqi
authors: R
authors: Gao
authors: Erin K
authors: EK
authors: Stachowski
authors: Allan R
authors: AR
authors: Sampson
authors: David A
authors: DA
authors: Lewis
authors: Peter
authors: P
authors: Penzes
authors: Robert A
authors: RA
authors: Sweet
mesh_terms: D000328:Adult; D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism / Q000473:pathology; D015153:Blotting, Western; D003712:Dendrites / Q000378:metabolism / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D018613:Microscopy, Confocal; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*
chemical_list: D020662:Guanine Nucleotide Exchange Factors; C503866:KALRN protein, human; D017346:Protein Serine-Threonine Kinases