title: The biology of HIFα proteins in cell differentiation and disease.
abstract: The biology of the α subunits of the hypoxia-inducible factors (HIFα) has expanded in the past years from their original role in angiogenesis to their nowadays position in the self-renewal and differentiation of stem cells. Hypoxia is a physiological condition in different tissues-including tumors-and, may cause stem cells in the onset of genomic instability, this last associated in the scientific literature with the acquisition of a malignant phenotypes. HIFα proteins have been the subjects of excellent scientific contributions in the past years, providing new paradigms in the biology of these key proteins and their pivotal role in cell homeostasis. Over other therapeutic implications, the relevance of studies focused on the etiology of tumor-initiating cells and the characterization of the mechanisms that could lead to their malignancy, is gaining significance in the health areas of cancer and regenerative medicine.
authors: Molecular Pharmacology Unit, Molecular Medicine Department, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors: Inmaculada Royo
authors: IR
authors: González
authors: Victoria
authors: V
authors: Moreno-Manzano
authors: Francisco Javier
authors: FJ
authors: Rodríguez-Jimenez
authors: Pilar
authors: P
authors: Sepúlveda
authors: José-María
authors: JM
authors: Sánchez-Puelles
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000737:chemistry / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins; D020033:Protein Isoforms