title: The relationship between the antioxidant system and anaemia in haemodialysis patients.
abstract: Anaemia and oxidative stress are common features of chronic kidney disease, and both are associated with an increase in morbidity and mortality. There is growing evidence, from experimental and clinical studies, that oxidative stress may be implicated in the pathogenesis of anaemia.  This study investigated the relationship between total antioxidant capacity, anaemia and serum albumin levels in 127 non-diabetic patients requiring haemodialysis. Total serum antioxidant capacity levels were determined and were found to be significantly correlated with levels of haemoglobin,  haematocrit, serum albumin, serum total protein, malondialdehyde (a product of lipid peroxidation), potassium, phosphorus and alanine transaminase. There was also a significant correlation between serum albumin levels and haemoglobin and haematocrit levels. In conclusion, total antioxidant  capacity was found to be inversely correlated with malondialdehyde levels and positively correlated with haemoglobin and haematocrit levels in non-diabetic patients requiring haemodialysis. Patients with high serum albumin concentrations and high total antioxidant capacity may also have high  (i.e. normal) levels of haemoglobin.
authors: Department of Internal Medicine, Division of Nephrology, Selçuklu School of Medicine, Selçuk University, 42250 Selçuklu, Konya, Turkey. gulpericelik@gmail.com
authors: G
authors: G
authors: Celik
authors: M
authors: M
authors: Yöntem
authors: M
authors: M
authors: Bilge
authors: M
authors: M
authors: Cilo
authors: M
authors: M
authors: Ünaldi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D006454:Hemoglobins; D012709:Serum Albumin; D008315:Malondialdehyde