title: The effect of exercise training on obstructive sleep apnea and sleep quality: a randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy of a 12-week exercise training program for reducing obstructive sleep apnea (OSA) severity and improving sleep quality, and to explore possible mechanisms by which exercise may reduce OSA severity.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Clinical exercise physiology center, sleep laboratory.
  
  
  METHODS
  Forty-three sedentary and overweight/obese adults aged 18-55 years with at least moderate-severity untreated OSA (screening apnea-hypopnea index [AHI] ≥ 15).
  
  
  METHODS
  Participants randomized to exercise training (n = 27) met 4 times/week for 12 weeks and performed 150 min/week of moderate-intensity aerobic activity, followed by resistance training twice/week. Participants randomized to a stretching control (n = 16) met twice weekly for 12 weeks to perform low-intensity exercises designed to increase whole-body flexibility.
  
  
  RESULTS
  OSA severity was assessed with one night of laboratory polysomnography (PSG) before and following the 12-week intervention. Measures of sleep quality included PSG, actigraphy (7-10 days), and the Pittsburgh Sleep Quality Index. Compared with stretching, exercise resulted in a significant AHI reduction (exercise: 32.2 ± 5.6 to 24.6 ± 4.4, stretching: 24.4 ± 5.6 to 28.9 ± 6.4; P < 0.01) as well as significant changes in oxygen desaturation index (ODI; P = 0.03) and stage N3 sleep (P = 0.03). Reductions in AHI and ODI were achieved without a significant decrease in body weight. Improvements in actigraphic sleep and subjective sleep quality were also noted following exercise compared with stretching.
  
  
  CONCLUSIONS
  Exercise training had moderate treatment efficacy for the reduction of AHI in sedentary overweight/obese adults, which suggests that exercise may be beneficial for the management of OSA beyond simply facilitating weight loss.
  
  
  BACKGROUND
  Clinicaltrials.gov identification number NCT00956423.
authors: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. klinec@upmc.edu
authors: Christopher E
authors: CE
authors: Kline
authors: E Patrick
authors: EP
authors: Crowley
authors: Gary B
authors: GB
authors: Ewing
authors: James B
authors: JB
authors: Burch
authors: Steven N
authors: SN
authors: Blair
authors: J Larry
authors: JL
authors: Durstine
authors: J Mark
authors: JM
authors: Davis
authors: Shawn D
authors: SD
authors: Youngstedt
mesh_terms: D000293:Adolescent; D000328:Adult; D005081:Exercise Therapy / Q000379:methods; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy; D010349:Patient Compliance; D017286:Polysomnography; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult