title: Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction.
abstract: OBJECTIVE
  Mean platelet volume (MPV) is an indicator of platelet activation, which is a central process in the pathophysiology of coronary heart disease. Metabolic syndrome (MS) may lead to worsened left ventricular systolic function by causing recurrent thrombotic events and by aggravating systemic inflammation in the course of acute myocardial infarction. The present study was designed to investigate the relationship between MPV and left ventricular systolic function in patients with metabolic syndrome who had first ST-elevation myocardial infarction.
  
  
  METHODS
  MPV was measured on admission in 33 patients who had preserved left ventricle systolic function (mean age, 56.9±10.2 years) and in 48 patients who had depressed left ventricle systolic function (mean age, 57.9±10.5 years) with metabolic syndrome and first ST elevation myocardial infarction. Depressed left ventricle systolic function was defined as ≤50% ejection fraction value. MPV levels were compared in the two groups.
  
  
  RESULTS
  MPV was significantly higher in patients with depressed left ventricle systolic function in comparison with patients showing preserved left ventricle systolic function (p=0.02). Logistic regression analysis showed an independent relationship between MPV and deteriorated left ventricular systolic function, even after adjustment for potential confounders (1.08 (1.04-1.20), CI: 95%, p=0.02).
  
  
  CONCLUSIONS
  Increased MPV on admission can be associated with degree of left ventricle systolic depression in patients with metabolic syndrome with first ST-elevation myocardial infarction. MPV may prove to be useful as a prognostic marker in patients with metabolic syndrome and ST elevation MI.
authors: Department of Cardiology, Gazi University School of Medicine, Ankara, Turkey. drhyazici@gmail.com
authors: Huseyin U
authors: HU
authors: Yazici
authors: Fatih
authors: F
authors: Poyraz
authors: Nihat
authors: N
authors: Sen
authors: Yusuf
authors: Y
authors: Tavil
authors: Murat
authors: M
authors: Turfan
authors: Murat
authors: M
authors: Tulmaç
authors: Adnan
authors: A
authors: Abacı
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000473:pathology*; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D010976:Platelet Count / Q000706:statistics & numerical data; D011379:Prognosis; D016277:Ventricular Function, Left