title: A PLA1-2 punch regulates the Golgi complex.
abstract: The mammalian Golgi complex, trans Golgi network (TGN) and ER-Golgi intermediate compartment (ERGIC) are comprised of membrane cisternae, coated vesicles and membrane tubules, all of which contribute to membrane trafficking and maintenance of their unique architectures. Recently, a new cast of players was discovered to regulate the Golgi and ERGIC: four unrelated cytoplasmic phospholipase A (PLA) enzymes, cPLA(2)α (GIVA cPLA(2)), PAFAH Ib (GVIII PLA(2)), iPLA(2)-β (GVIA-2 iPLA(2)) and iPLA(1)γ. These ubiquitously expressed enzymes regulate membrane trafficking from specific Golgi subcompartments, although there is evidence for some functional redundancy between PAFAH Ib and cPLA(2)α. Three of these enzymes, PAFAH Ib, cPLA(2)α and iPLA(2)-β, exert effects on Golgi structure and function by inducing the formation of membrane tubules. We review our current understanding of how PLA enzymes regulate Golgi and ERGIC morphology and function.
authors: Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853, USA.
authors: Marie E
authors: ME
authors: Bechler
authors: Paul
authors: P
authors: de Figueiredo
authors: William J
authors: WJ
authors: Brown
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000201:enzymology; D006056:Golgi Apparatus / Q000201:enzymology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D054467:Phospholipases A2 / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D008869:Microtubule-Associated Proteins; D054467:Phospholipases A2