title: Clinical outcomes after surgical resection of colorectal cancer in 1,294 patients.
abstract: OBJECTIVE
  This study aimed to determine the overall survival time and clinical characteristics affecting the outcomes in patients with resectable colorectal cancer (CRC).
  
  
  METHODS
  Clinical data from CRC patients who underwent surgical resections from 1994 to 2004 was analyzed retrospectively using the documented records and gastrointestinal tumor databases at the gastrointestinal institute. Univariate and multivariate analyses were conducted to investigate the association between clinical variables and overall survival time.
  
  
  RESULTS
  A consecutive series of 1.294 CRC patients were enrolled for the final analyses. The five-year survival rates were 94.1%, 80.2%, 61.7% and 23.2% of patients with stage from I to IV CRC, respectively. One hundred and seven patients (8.3%) had disease recurrence during the follow-up with a median of 50.3 months. After radical surgical resections, patients with recurrence could still expect a five-year survival rate of 44.3%. Multivariate analysis showed that patient age >60 years, infiltrative tumor type, intestinal obstruction, poor tumor differentiation, disease recurrence and late TNM stage were associated with poor survival (all p<0.05).
  
  
  CONCLUSIONS
  The overall postoperative survival in this series of patients with CRC was mainly affected by patient age, tumor morphology, bowel obstruction, histological grade, TNM stage and disease recurrence. For those patients with recurrence, surgical resection should be recommended primarily if the tumor is resectable.
authors: Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors: Yanxin
authors: Y
authors: Luo
authors: Ji
authors: J
authors: Cui
authors: Chuangqi
authors: C
authors: Chen
authors: Shunxin
authors: S
authors: Song
authors: Meijin
authors: M
authors: Huang
authors: Junsheng
authors: J
authors: Peng
authors: Ping
authors: P
authors: Lan
authors: Yihua
authors: Y
authors: Huang
authors: Lei
authors: L
authors: Wang
authors: Jianping
authors: J
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D055815:Young Adult