title: Associations of IL-23R polymorphisms with ankylosing spondylitis in East Asian population: a new case-control study and a meta-analysis.
abstract: Interleukin-23 receptor (IL-23R) has been confirmed to be associated with ankylosing spondylitis (AS) in Caucasian. However, whether they are associated with AS in East Asian population remains unidentified. Here, we conducted a new case-control study investigating this relationship in Chinese Han population and then performed a meta-analysis in East Asian population. The Chinese Han study included 200 cases and 200 controls. Genotyping was completed using the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Allelic associations were analysed using contingency tables. In the meta-analysis, 1384 cases and 1710 controls from five different studies and the new Chinese Han study were combined using Review Manager software Version 5.1.1. Mantel-Haenszel test was used to calculate fixed effects pooled ORs. No association with AS was observed in the Chinese Han study. Meta-analysis showed that no SNP was significantly associated with AS in East Asian population. In conclusion, we found no evidence for association between IL-23R and AS in East Asian population. Major attention should be paid to other genes belonged to IL-23 signalling pathway network in the future.
authors: Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, School ofRehabilitation Medicine, Capital Medical University, Beijing, China.
authors: C
authors: C
authors: Chen
authors: X
authors: X
authors: Zhang
authors: J
authors: J
authors: Li
authors: Y
authors: Y
authors: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D012307:Risk Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013167:Spondylitis, Ankylosing / Q000208:ethnology / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin