title: Integrating human and murine anatomical gene expression data for improved comparisons.
abstract: BACKGROUND
  Information concerning the gene expression pattern in four dimensions (species, genes, anatomy and developmental stage) is crucial for unraveling the roles of genes through time. There are a variety of anatomical gene expression databases, but extracting information from them can be hampered by their diversity and heterogeneity.
  
  
  RESULTS
  aGEM 3.1 (anatomic Gene Expression Mapping) addresses the issues of diversity and heterogeneity of anatomical gene expression databases by integrating six mouse gene expression resources (EMAGE, GXD, GENSAT, Allen Brain Atlas data base, EUREXPRESS and BioGPS) and three human gene expression databases (HUDSEN, Human Protein Atlas and BioGPS). Furthermore, aGEM 3.1 provides new cross analysis tools to bridge these resources.
  
  
  METHODS
  aGEM 3.1 can be queried using gene and anatomical structure. Output information is presented in a friendly format, allowing the user to display expression maps and correlation matrices for a gene or structure during development. An in-depth study of a specific developmental stage is also possible using heatmaps that relate gene expression with anatomical components. http://agem.cnb.csic.es
  
  
  BACKGROUND
  natalia@cnb.csic.es
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors: GN7 of the National Institute for Bioinformatics, Darwin, 3, 28049 Madrid, Spain. natalia@cnb.csic.es
authors: Natalia
authors: N
authors: Jiménez-Lozano
authors: Joan
authors: J
authors: Segura
authors: José Ramón
authors: JR
authors: Macías
authors: Juanjo
authors: J
authors: Vega
authors: José María
authors: JM
authors: Carazo
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D051379:Mice; D009928:Organ Specificity