title: Intracellular glutathione detection using MnO(2)-nanosheet-modified upconversion nanoparticles.
abstract: We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO(2)) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO(2) into Mn(2+). The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.
authors: Department of Chemistry, National University of Singapore, Singapore 117543.
authors: Renren
authors: R
authors: Deng
authors: Xiaoji
authors: X
authors: Xie
authors: Marc
authors: M
authors: Vendrell
authors: Young-Tae
authors: YT
authors: Chang
authors: Xiaogang
authors: X
authors: Liu
mesh_terms: D045744:Cell Line, Tumor; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D049449:Luminescence; D017895:Manganese Compounds / Q000378:metabolism*; D053758:Nanoparticles; D010087:Oxides / Q000378:metabolism*
chemical_list: D017895:Manganese Compounds; D010087:Oxides; C027424:manganese oxide; D005978:Glutathione