title: Cytotoxic dinuclear titanium-salan complexes: structural and biological characterization.
abstract: Controlled hydrolysis of donor-substituted titanium-salan complexes led to the formation of well-defined dinuclear complexes. Structure determination by means of X-ray and NMR-studies revealed the presence of a single μ-oxo bridge and one labile alkoxide ligand per titanium center. Concomitant cytotoxicity assays of the isolated dinuclear complexes showed cytotoxicities in the low micro-molar region, surpassing in this respect even their monomeric ancestors, thus making them possible highly active metabolites of titanium-salan anti-cancer drugs.
authors: Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Konstanz, Germany.
authors: Timo A
authors: TA
authors: Immel
authors: Martin
authors: M
authors: Grützke
authors: Ellen
authors: E
authors: Batroff
authors: Ulrich
authors: U
authors: Groth
authors: Thomas
authors: T
authors: Huhn
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D014025:Titanium