title: Synthesis, characterization and biomedical properties of UV-cured polyurethane acrylates containing a phosphorylcholine structure.
abstract: In order to develop a simple, economical and rapid approach to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) with other monomers without any solvent, we prepared a series of ultraviolet cured poly(urethane acrylate) (PUA) membranes containing different MPC content. Their chemical structure and surface properties were investigated by FT-IR, XPS, water swelling ratio and water contact angle measurement, while the biocompatibilities were evaluated through fibrinogen adsorptions, platelet adhesion and plasma recalcification time determination. The results demonstrate that the phosphorylcholine (PC) groups were successfully introduced into the PUA system by the UV-curing approach and the all PC-containing membranes showed better biocompatibility than those without PC moiety. The UV-curing method is potentially to be applied in the coating of medical devices which require biocompatibility and manufacturing efficiency.
authors: a Department of Materials Science and Engineering , College of Engineering and Applied Sciences, Nanjing University , Nanjing , 210093 , P. R. China.
authors: Yihui
authors: Y
authors: Xu
authors: Anxin
authors: A
authors: Dong
authors: Yufeng
authors: Y
authors: Zhao
authors: Tao
authors: T
authors: Zhang
authors: Zhengsheng
authors: Z
authors: Jiang
authors: Shasha
authors: S
authors: Wang
authors: Hong
authors: H
authors: Chen
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D002113:Calcification, Physiologic; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008567:Membranes, Artificial; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D010949:Plasma / Q000737:chemistry; D010973:Platelet Adhesiveness; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D008567:Membranes, Artificial; D008689:Methacrylates; D011140:Polyurethanes; D012997:Solvents; C050845:urethane acrylate; D014867:Water; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; D005340:Fibrinogen; D009113:Muramidase