title: Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug.
abstract: We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.
authors: Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Madurai 625 021, Tamilnadu, India.
authors: Mariappan
authors: M
authors: Babu
authors: Kasi
authors: K
authors: Pitchumani
authors: Penugonda
authors: P
authors: Ramesh
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007555:Isoxazoles / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D007555:Isoxazoles; D011804:Quinolines; C037920:decahydroquinoline-5-carboxylic acid; D009584:Nitrogen