title: Impact of congestive heart failure treatment on peripheral microvascular tissue oxygenation.
abstract: The authors evaluated peripheral tissue oxygenation during treatment of acutely decompensated congestive heart failure (CHF) to determine whether differences exist between patients who experienced adverse outcomes (AO), defined as death or readmission within 6 months, and patients who did not (non-AO). This prospective, observational study measured differential absorption spectroscopy-derived tissue hemoglobin oxygenation (S(t) O(2) ) in CHF patients from presentation through hospital discharge to determine whether differences between the AO and non-AO groups exist. Of 52 patients, 6 died and 27 were readmitted. In the non-AO group, S(t) O(2) increased from admission to discharge by 5.2% ( P<.01; 95% confidence interval, 1.7%-8.7%). No S(t) O(2) change occurred in the AO group (2.3%; P=.42; 95% CI, -2.2%-6.8%). Tissue oxygenation increased during inpatient treatment in CHF patients without future adverse outcomes, but was unchanged for those who later died or were readmitted. Lack of improvement may be associated with higher rates of death and readmission.
authors: Virginia Commonwealth University Reanimation Engineering Science Center, Virginia Commonwealth University Medical Center, Richmond, USA. chogan@mcvh-vcu.edu
authors: Christopher J
authors: CJ
authors: Hogan
authors: Kevin R
authors: KR
authors: Ward
authors: Roland C
authors: RC
authors: Pittman
authors: Michael C
authors: MC
authors: Kontos
authors: Leroy R
authors: LR
authors: Thacker
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism; D011446:Prospective Studies; D012720:Severity of Illness Index; D013057:Spectrum Analysis; D014655:Vascular Resistance / Q000502:physiology*
chemical_list: D010108:Oxyhemoglobins