title: Analysis of skeletal muscle hypertrophy in models of increased loading.
abstract: Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.
authors: Department of Neurobiology, University of California, Davis, CA, USA. scbodine@ucdavis.edu
authors: Sue C
authors: SC
authors: Bodine
authors: Keith
authors: K
authors: Baar
mesh_terms: D000818:Animals; D006984:Hypertrophy; D008722:Methods; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology*; D011506:Proteins / Q000032:analysis; D051381:Rats
chemical_list: D011506:Proteins