title: [Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis].
abstract: OBJECTIVE
  Matrix metallopeptidase (MMP) is known to be involved in tumor invasion and metastasis of cancer. This study investigated the association of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 with gastric cancer (GC) development and lymph node metastasis (LNM).
  
  
  METHODS
  Samples were obtained from 326 chronic gastritis (CG) and 153 GC patients and genotyped by using the GoldenGate® method. Chi-square test was performed to identify the difference of allele distribution between each group (CG vs. GC; CG vs. with LNM GC). The associations of genotype with risk of GC and LNM were estimated by odds ratio and the 95% confidence interval was calculated by logistic regression adjusting for age and sex.
  
  
  RESULTS
  The allele and genotype frequencies of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 were not associated with the development of GC and LNM.
  
  
  CONCLUSIONS
  In summary, MMP7 rs11568818, MMP8 rs11225395 MMP9 rs17576 and rs2250889 were not associated with the GC development and LNM in Korean population.
authors: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
authors: Ji Hye
authors: JH
authors: Kim
authors: Jung A
authors: JA
authors: Pyun
authors: Kwang Jae
authors: KJ
authors: Lee
authors: Sung Won
authors: SW
authors: Cho
authors: Kyu Bum
authors: KB
authors: Kwack
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D002908:Chronic Disease; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D020784:Matrix Metalloproteinase 8 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D020783:Matrix Metalloproteinase 7; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9