title: [Advances on Drosophila presenilin gene].
abstract: In Drosophila, presenilin is an aspartyl protease that plays important roles in the development and calcium homeostasis. It has been expressed all through the fly developmental process. The loss of Drosophila presenilin (DPS) function causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. This subsequently led to impaired long term memory and cognitive deficits. Therefore, study of DPS is one of the most popular models for Alzheimer's disease research, and has provided important insights into the pathological mechanisms of AD. This review is to summarize the AD related function of DPS gene.
authors: College of Life Sciences, Shanghai University, Shanghai, China. zhangyucgq@yahoo.com.cn
authors: Yu
authors: Y
authors: Zhang
authors: Zeng-Zhang
authors: ZZ
authors: Zheng
authors: Jun
authors: J
authors: Ge
authors: Hong-Yan
authors: HY
authors: Zhang
authors: Yan-Wang
authors: YW
authors: Huang
authors: Hong-Sheng
authors: HS
authors: Song
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D053763:Presenilins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D053763:Presenilins; C106427:Psn protein, Drosophila; D002118:Calcium