title: Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.
abstract: OBJECTIVE
  The assessment of the serum gastrin concentrations and the role of enterohormone in children with primary acid gastroesophageal reflux (GER) and GER secondary to cow's milk allergy (CMA).
  
  
  METHODS
  138 children were diagnosed with pathological acid GER on the basis of pH-metric examination. 76 (28.8%) patients had primary GER and 62 (23.5%) patients had GER secondary to CMA.Serum gastrin concentration (fasting and postprandial) was assessed before treatment and 1 and 2 years after initiation of the therapy.
  
  
  RESULTS
  The children with primary GER had the fasting gastrin concentration 69.46 ± 11.87 μU/ml before treatment, 77.86 ± 26.35 μU/ml after 1 year and 83.78 ± 25.21 μU/ml after 2 years of treatment. The children with GER secondary to CMA had gastrin concentrations 89.61 ± 26.75, 73.17 ± 19.49 and 73.90 ± 20.31 μU/ml respectively. The mean postprandial gastrin concentration after treatment was higher than before treatment in children with both primary and secondary GER. The primary GER group had postprandial gastrin concentration 96.07 ± 33.51 μU/ml before treatment and 116.06 ± 33.95 μU/ml and 118.48 ± 33.96 μU/ml after 1st and 2nd year of therapy respectively. The secondary GER group had postprandial gastrin concentration 85.33 ± 14.12 μU/ml before treatment and 106.55 ± 24.51 μU/ml and 110.36 ± 24.67 μU/ml after 1st and 2nd year of therapy respectively.
  
  
  CONCLUSIONS
  The mean fasting serum gastrin concentrations in patients with primary and secondary GER were similar and mean postprandial concentrations were higher than fasting concentrations in both study groups.
authors: Department of Pediatrics, Pediatric Gastroenterology and Allergology, Medical University of Bialystok, Bialystok, Poland. janexik@poczta.onet.pl
authors: J
authors: J
authors: Semeniuk
authors: M
authors: M
authors: Kaczmarski
authors: J
authors: J
authors: Wasilewska
mesh_terms: D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D050782:Esophageal pH Monitoring; D005260:Female; D005512:Food Hypersensitivity; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D005764:Gastroesophageal Reflux / Q000097:blood* / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D008892:Milk; D016269:Milk Hypersensitivity / Q000097:blood* / Q000150:complications; D019518:Postprandial Period; D013997:Time Factors
chemical_list: D005755:Gastrins