title: Prevalence of antibodies against enterovirus 71 in children from Lu'an City in Central China.
abstract: We performed preepidemic and postepidemic serologic surveys to elucidate the rate of  enterovirus 71 (EV71) infection in Lu'an City, Anhui Province, Central China. For the preepidemic  study, a total of 472 healthy infants and children (age range, neonates to 15 years) were randomly  selected before the 2008 outbreak of EV71 in the region. Blood samples were collected and tested  for neutralizing antibodies (NAbs) against EV71 by performing a microneutralization assay. The  results of preepidemic serological survey showed that 43.2% (204/472) of the tested samples yielded  positive results for NAbs against EV71. The seropositivity rates were 29.6% (93/314) in children  who were 0-7 years of age and 74.6% (59/79) in children who were 12-15 years of age. The overall  geometric mean titer was 18.1, and the highest antibody titers were detected in children who were  5-7 years of age; this suggests that this group was frequently exposed to EV71 infection. For the  postepidemic study, 83 serum samples were collected from healthy children ≤15 years of age in 2010.  The seropositivity rate of EV71 NAbs increased in this young population after the 2008 outbreak,  especially in 2- to 11-year-old children. This report shows that EV71 was spreading in Lu'an City  before the 2008 outbreak, and children under 7 years of age were the main susceptible population.
authors: Department of Microbiology, Anhui Medical University, Hefei, China.
authors: Haiyang
authors: H
authors: Yu
authors: Mingli
authors: M
authors: Wang
authors: Hongwei
authors: H
authors: Chang
authors: Jie
authors: J
authors: Lu
authors: Baojing
authors: B
authors: Lu
authors: Jingpei
authors: J
authors: Li
authors: Wei
authors: W
authors: Chen
authors: Renshu
authors: R
authors: Tang
authors: Lin
authors: L
authors: Gan
authors: Jun
authors: J
authors: Zhao
authors: Boyu
authors: B
authors: Liu
authors: Jason
authors: J
authors: Chen
mesh_terms: D000293:Adolescent; D000367:Age Factors; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D001769:Blood / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000276:immunology / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009500:Neutralization Tests; D016036:Seroepidemiologic Studies
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral