title: Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation.
abstract: The purpose of this study was the in vitro and in vivo evaluation of the masking efficiency of hot melt extruded paracetamol (PMOL) formulations. Extruded granules containing high PMOL loadings in Eudragit EPO (EPO) or Kollidon VA64 (VA64) were prepared by hot-melt extrusion (HME). The taste masking effect of the processed formulation was evaluated in vivo by a panel of six healthy human volunteers. In addition, in vitro evaluation was carried out by an Astree e-tongue equipped with seven sensors. Taste sensing technology demonstrated taste improvement for both polymers by correlating the data obtained for the placebo polymers and the pure APIs alone. The best masking effect was observed for VA64 at 30% PMOL loading. The e-tongue results were in good agreement with the in vivo evaluation. In vitro dissolution of the extruded granules showed rapid PMOL releases.
authors: School of Science, University of Greenwich, Kent, United Kingdom.
authors: Mohammed
authors: M
authors: Maniruzzaman
authors: Joshua S
authors: JS
authors: Boateng
authors: Marion
authors: M
authors: Bonnefille
authors: Attila
authors: A
authors: Aranyos
authors: John C
authors: JC
authors: Mitchell
authors: Dennis
authors: D
authors: Douroumis
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry*; D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D012995:Solubility; D013649:Taste; D013678:Technology, Pharmaceutical / Q000379:methods*; D044366:Transition Temperature; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen