title: Recurrent lobar intracerebral hemorrhage in Tangier disease.
abstract: We report a patient with familial α-lipoprotein deficiency (Tangier disease) who presented with recurrent lobar intracerebral hemorrhages and accumulating microbleeds on T*2-weighted magnetic resonance imaging, suggestive of probable cerebral amyloid angiopathy. This case provides new insight into the links between the adenotriphosphate-binding cassette A1 (ABCA1) transporter gene mutation in Tangier disease and apolipoprotein-E expression in the brain and supports further investigation of the potential role of ABCA1 transporter in cerebral amyloid angiopathy.
authors: Department of Neurology, Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors: Wuwei
authors: W
authors: Feng
authors: Evgeny
authors: E
authors: Sidorov
authors: Kara
authors: K
authors: Smith
authors: Magdy
authors: M
authors: Selim
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D001057:Apolipoproteins E / Q000378:metabolism; D016657:Cerebral Amyloid Angiopathy / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D002533:Cerebral Angiography / Q000379:methods; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D012008:Recurrence; D013631:Tangier Disease / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D001057:Apolipoproteins E