title: NRPSsp: non-ribosomal peptide synthase substrate predictor.
abstract: CONCLUSIONS
  Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity. The discovery and characterization of non-ribosomal peptides are of great interest for the biotechnological industries. We have applied computational mining methods in order to build a database of NRPSs modules that bind to specific substrates. We have used this database to build a hidden Markov model predictor of substrates that bind to a given NRPS.
  
  
  BACKGROUND
  The database and the predictor are freely available on an easy-to-use website at www.nrpssp.com.
  
  
  BACKGROUND
  carlos.prieto@unileon.es
  
  
  BACKGROUND
  Supplementary data is available at Bioinformatics online.
authors: Institute of Biotechnology of Leon, INBIOTEC, Parque Científico de León, 24006 León, Spain. carlos.prieto@unileon.es
authors: Carlos
authors: C
authors: Prieto
authors: Carlos
authors: C
authors: García-Estrada
authors: Diego
authors: D
authors: Lorenzana
authors: Juan Francisco
authors: JF
authors: Martín
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000378:metabolism; D005658:Fungi / Q000201:enzymology / Q000378:metabolism; D008390:Markov Chains; D010453:Peptide Synthases / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase