title: Infectious agents associated with schizophrenia: a meta-analysis.
abstract: Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p<0.01), Human Endogenous Retrovirus W (OR=19.31; CI 95%: 6.74-55.29; p<0.001), Chlamydophila pneumoniae (OR=6.34; CI 95%: 2.83-14.19; p<0.001), Chlamydophila psittaci (OR=29.05; CI 95%: 8.91-94.70; p<0.001) and Toxoplasma gondii (OR=2.70; CI 95%: 1.34-4.42; p=0.005). The implications of these findings are discussed and further research options are also explicated.
authors: CAP El Clot, Institut Català de la Salut, Barcelona, Spain.
authors: Isabel
authors: I
authors: Arias
authors: Antonio
authors: A
authors: Sorlozano
authors: Enrique
authors: E
authors: Villegas
authors: Juan
authors: J
authors: de Dios Luna
authors: Kathryn
authors: K
authors: McKenney
authors: Jorge
authors: J
authors: Cervilla
authors: Blanca
authors: B
authors: Gutierrez
authors: Jose
authors: J
authors: Gutierrez
mesh_terms: D001890:Borna Disease / Q000453:epidemiology; D023521:Chlamydophila Infections / Q000453:epidemiology; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006558:Herpes Genitalis / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology* / Q000276:immunology*; D008297:Male; D012559:Schizophrenia / Q000453:epidemiology* / Q000276:immunology*; D014123:Toxoplasmosis / Q000453:epidemiology