title: The analgesic effect of dexketoprofen when added to lidocaine for intravenous regional anaesthesia: a prospective, randomized, placebo-controlled study.
abstract: This prospective, randomized, placebo-controlled study evaluated the effects of dexketoprofen as an adjunct to lidocaine in intravenous regional anaesthesia (IVRA) or as a supplemental intravenous (i.v.) analgesic. Patients scheduled for elective hand or forearm soft-tissue surgery were  randomly divided into three groups. All 45 patients received 0.5% lidocaine as IVRA. Dexketoprofen was given either i.v. or added into the IVRA solution and the control group received an equal volume of saline both i.v. and as part of the IVRA. The times of sensory and motor block onset, recovery  time and postoperative analgesic consumption were recorded. Compared with controls, the addition of dexketoprofen to the IVRA solution resulted in more rapid onset of sensory and motor block, longer recovery time, decreased intra- and postoperative pain scores and decreased paracetamol use.  It is concluded that coadministration of dexketoprofen with lidocaine in IVRA improves anaesthetic block and decreases postoperative analgesic requirements.
authors: Department of Anaesthesiology and Reanimation, Zonguldak Karaelmas University, School of Medicine, Kozlu, Zonguldak, Turkey.
authors: S
authors: S
authors: Yurtlu
authors: V
authors: V
authors: Hanci
authors: E
authors: E
authors: Kargi
authors: G
authors: G
authors: Erdoğan
authors: B G
authors: BG
authors: Köksal
authors: Ş
authors: Ş
authors: Gül
authors: R D
authors: RD
authors: Okyay
authors: H
authors: H
authors: Ayoğlu
authors: I Ö
authors: IÖ
authors: Turan
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001132:Arm / Q000601:surgery; D001794:Blood Pressure; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006225:Hand / Q000601:surgery; D006339:Heart Rate; D006801:Humans; D007432:Intraoperative Period; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D011446:Prospective Studies; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D014325:Tromethamine; D007660:Ketoprofen; D008012:Lidocaine; C118296:dexketoprofen trometamol