title: Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients.
abstract: BACKGROUND
  Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease.
  
  
  METHODS
  The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications.
  
  
  RESULTS
  Diabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P<0.001 and OR 1.152 with P<0.027, respectively). However, no significant correlations were found between sdLDL and major vascular complications (P=0.342), minor vascular complications (P=0.573) or overall vascular complications (P=0.262) in diabetic subjects.
  
  
  CONCLUSIONS
  Diabetic patients had a smaller mean-LDL particle size and higher proportion of sdLDL compared to those of subjects without diabetes. Obese diabetic patients with hypertriglyceridemia have an increased risk for atherogenic small dense LDL. However, we could not verify an association between LDL particle size and vascular complications in this study.
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Sunghwan
authors: S
authors: Suh
authors: Hyung-Doo
authors: HD
authors: Park
authors: Se Won
authors: SW
authors: Kim
authors: Ji Cheol
authors: JC
authors: Bae
authors: Alice Hyun-Kyung
authors: AH
authors: Tan
authors: Hye Soo
authors: HS
authors: Chung
authors: Kyu Yeon
authors: KY
authors: Hur
authors: Jae Hyeon
authors: JH
authors: Kim
authors: Kwang-Won
authors: KW
authors: Kim
authors: Moon-Kyu
authors: MK
authors: Lee