title: [Clinical analysis of non-tuberculous mycobacteriosis cases complicated with pulmonary aspergillosis].
abstract: OBJECTIVE
  To clarify the clinical features of nontuberculous mycobacteriosis (NTM) complicated with chronic pulmonary aspergillosis (CPA), we analyzed 257 cases diagnosed with newly developed NTM during the last 12 years in our hospital.
  
  
  RESULTS
  Fifty-six per cent of the patients were females. Ten cases (3.9%) of them were complicated with CPA in their clinical course. Mean age at the diagnosis of CPA was 65.5 years, and 8 of 10 cases were males. The average period from the diagnosis of NTM to CPA was almost 7 years. Six NTM cases were classified as the cavitary type and 4 as the nodular-bronchiectasis type. At the time of the diagnosis of CPA, NTM bacilli were isolated in 5 cases, but in the other 5 bacilli were not detected. Radiologically it was found that in many cases the infiltrative shadow had increased and the cavity wall had thickened. Antifungal drug administration was effective in 67% of the cases. In particular, in cases with progressive infiltrative shadows, the antifungal drug was effective in 83% of patients.
  
  
  CONCLUSIONS
  For the clinical management of NTM, careful attention to the complication of CPA is required.
authors: Department of Pulmonary Medicine, National Hospital Organization Matsue Medical Center, Shimane, Japan. ishi-kma@matsue.hosp.go.jp
authors: Shigenori
authors: S
authors: Ishikawa
authors: Shuichi
authors: S
authors: Yano
authors: Toru
authors: T
authors: Kadowaki
authors: Kiryo
authors: K
authors: Wakabayashi
authors: Masahiro
authors: M
authors: Kimura
authors: Kanako
authors: K
authors: Kobayashi
authors: Toshikazu
authors: T
authors: Ikeda
mesh_terms: D000368:Aged; D060085:Coinfection; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D055732:Pulmonary Aspergillosis / Q000150:complications*; D012189:Retrospective Studies