title: Raman microscopy of bone.
abstract: Raman microscopy is a non-destructive technique requiring minimal sample preparation that can be used to measure the chemical properties of the mineral and collagen parts of bone simultaneously. Modern Raman instruments contain the necessary components and software to acquire the standard information required in most bone studies. The spatial resolution of the technique is about a micron. As it is non-destructive and small samples can be used, it forms a useful part of a bone characterisation toolbox.
authors: Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK. s.goodyear@abdn.ac.uk
authors: Simon R
authors: SR
authors: Goodyear
authors: Richard M
authors: RM
authors: Aspden
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000737:chemistry; D001842:Bone and Bones / Q000737:chemistry*; D004867:Equipment Design; D051379:Mice; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D008903:Minerals / Q000032:analysis; D025341:Principal Component Analysis; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods*
chemical_list: D008903:Minerals