title: A manganese-ferritin nanocomposite as an ultrasensitive T2 contrast agent.
abstract: T(2) contrast is gaining importance in high field strength MRI. We report a strategy for developing a T(2) contrast agent from paramagnetic metal ions synthesized within an engineered protein cage. The manganese-ferritin nanocomposite showed high T(2) relaxivity indicating its potential as an ultrasensitive T(2) contrast agent.
authors: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457.
authors: Barindra
authors: B
authors: Sana
authors: Chueh Loo
authors: CL
authors: Poh
authors: Sierin
authors: S
authors: Lim
mesh_terms: D019611:Archaeoglobus fulgidus / Q000235:genetics; D003287:Contrast Media / Q000737:chemistry*; D004926:Escherichia coli / Q000235:genetics; D005293:Ferritins / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D011994:Recombinant Proteins / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission
chemical_list: D003287:Contrast Media; D011994:Recombinant Proteins; D008345:Manganese; D005293:Ferritins