title: The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage.
abstract: In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing "one pot" hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.
authors: Network of Excellence for Functional Biomaterials, National University of Ireland Galway, IDA Business Park, Galway, Ireland.
authors: Aram O
authors: AO
authors: Saeed
authors: Ben
authors: B
authors: Newland
authors: Abhay
authors: A
authors: Pandit
authors: Wenxin
authors: W
authors: Wang
mesh_terms: D000818:Animals; D002470:Cell Survival; D004220:Disulfides / Q000737:chemistry* / Q000378:metabolism; D005782:Gels / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D041681:NIH 3T3 Cells; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004220:Disulfides; D005782:Gels; D011108:Polymers