title: Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols.
abstract: 6,7-Bis(arylthio)-quinazoline-5,8-dione and furo[2,3-f]quinazolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many of furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones showed good antifungal activity. The compounds completely inhibited the growth of all against Candida and Aspergillus species tested at the MIC level of 12.5μg/mL. The results suggest that furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones would be promising antifungal agents.
authors: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr
authors: Chung-Kyu
authors: CK
authors: Ryu
authors: Yang Hui
authors: YH
authors: Kim
authors: Hyun Ah
authors: HA
authors: Im
authors: Ji Young
authors: JY
authors: Kim
authors: Joo Hee
authors: JH
authors: Yoon
authors: Aram
authors: A
authors: Kim
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000378:metabolism*; D002175:Candida / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003455:Cryptococcus neoformans / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D015725:Fluconazole / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D011799:Quinazolines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D011799:Quinazolines; D013438:Sulfhydryl Compounds; D015725:Fluconazole