title: Diagnosis and management of type I and type V hyperlipoproteinemia.
abstract: Both type I and type V hyperlipoproteinemia are characterized by severe hypertriglyceridemia due to an increase in chylomicrons. Type I hyperlipoproteinemia is caused by a decisive abnormality of the lipoprotein lipase (LPL)- apolipoprotein C-II system, whereas the cause of type V hyperlipoproteinemia is more complicated and more closely related to acquired environmental factors. Since the relationship of hypertriglyceridemia with atherosclerosis is not as clear as that of hypercholesterolemia, and since type I and V hyperlipoproteinemia are relatively rare, few guidelines for their diagnosis and treatment have been established; however, type I and V hyperlipoproteinemia are clinically important as underlying disorders of acute pancreatitis, and appropriate management is necessary to prevent or treat such complications. Against such a background, here we propose guidelines primarily concerning the diagnosis and management of type I and V hyperlipoproteinemia in Japanese.
authors: Department of Clinical and Molecular Epidemiology, 22nd Century Medical and Research Center, University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan. gotoda-tky@umin.ac.jp
authors: Takanari
authors: T
authors: Gotoda
authors: Koji
authors: K
authors: Shirai
authors: Takao
authors: T
authors: Ohta
authors: Junji
authors: J
authors: Kobayashi
authors: Shinji
authors: S
authors: Yokoyama
authors: Shinichi
authors: S
authors: Oikawa
authors: Hideaki
authors: H
authors: Bujo
authors: Shun
authors: S
authors: Ishibashi
authors: Hidenori
authors: H
authors: Arai
authors: Shizuya
authors: S
authors: Yamashita
authors: Mariko
authors: M
authors: Harada-Shiba
authors: Masaaki
authors: M
authors: Eto
authors: Toshio
authors: T
authors: Hayashi
authors: Hirohito
authors: H
authors: Sone
authors: Hiroaki
authors: H
authors: Suzuki
authors: Nobuhiro
authors: N
authors: Yamada
mesh_terms: D019468:Disease Management; D006801:Humans; D008072:Hyperlipoproteinemia Type I / Q000175:diagnosis* / Q000628:therapy*; D006954:Hyperlipoproteinemia Type V / Q000175:diagnosis* / Q000628:therapy*; D008071:Lipoprotein Lipase / Q000378:metabolism; D017410:Practice Guidelines as Topic
chemical_list: D008071:Lipoprotein Lipase