title: The incidence of postoperative nausea and vomiting after thyroidectomy using three anaesthetic techniques.
abstract: The choice of anaesthetics can affect the incidence of postoperative nausea and vomiting (PONV). This study compared the incidence of PONV in 177 female patients who underwent thyroidectomy, with anaesthesia induced and maintained using one of three regimens: (i) sevoflurane (thiopental  sodium 4 - 5 mg/kg and sevoflurane 2.0 - 2.5 vol% in 50% air); (ii) total intravenous anaesthesia (TIVA; propofol-remifentanil [target blood concentrations 2.5 - 3.5 μg/ml and 3.5 - 4.5 ng/ml, respectively]); or (iii) combined inhalation and intravenous anaesthesia  (sevoflurane 1.0 vol% in 50% air plus propofol-remifentanil [target blood concentrations 1.5 - 2.5 μg/ml and 2.5 - 3.5 ng/ml, respectively]). The incidence and severity of PONV and the need for rescue antiemetics were assessed at 0 - 24 h postoperatively. Overall,  the incidence of PONV was significantly lower in the TIVA and combined groups compared with the sevoflurane group (33.9%, 39.0% and 64.4%, respectively). In conclusion, the maintenance of anaesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased  the incidence of PONV compared with sevoflurane alone.
authors: Department of Anaesthesia and Pain Medicine, Ajou University, School of Medicine, Youngtong-Gu, Suwon, Republic of Korea.
authors: Y J
authors: YJ
authors: Won
authors: J Y
authors: JY
authors: Yoo
authors: Y J
authors: YJ
authors: Chae
authors: D H
authors: DH
authors: Kim
authors: S K
authors: SK
authors: Park
authors: H B
authors: HB
authors: Cho
authors: J S
authors: JS
authors: Kim
authors: J H
authors: JH
authors: Lee
authors: S Y
authors: SY
authors: Lee
mesh_terms: D000328:Adult; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D005260:Female; D006801:Humans; D015994:Incidence; D008738:Methyl Ethers; D008875:Middle Aged; D010880:Piperidines; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000517:prevention & control*; D015742:Propofol; D000077208:Remifentanil; D000077149:Sevoflurane; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil; D015742:Propofol