title: Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study.
abstract: OBJECTIVE
  Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony.
  
  
  METHODS
  For the normal population 80 patients (40 men and 40 women) with normal perfusion (summed stress score ≤2 and summed rest score ≤2) and function (left ventricular ejection fraction 55-80%) on MPS were selected; 24 heart failure patients with proven dyssynchrony on MRI were selected for comparison. All patients underwent a 2-day stress/rest MPS protocol. Perfusion, function and dyssynchrony parameters were obtained by the Corridor4DM software package (Version 6.1).
  
  
  RESULTS
  For the normal population time to peak motion was 42.8 ± 5.1% RR cycle, SD of time to peak motion was 3.5 ± 1.4% RR cycle and bandwidth was 18.2 ± 6.0% RR cycle. No significant gender-related differences or differences between rest and post-stress acquisition were found for the dyssynchrony parameters. Discrepancies between the normal and abnormal populations were most profound for the mean wall motion (p value <0.001), SD of time to peak motion (p value <0.001) and bandwidth (p value <0.001).
  
  
  CONCLUSIONS
  It is feasible to quantify ventricular dyssynchrony in MPS using the geometrical approach as implemented by Corridor4DM.
authors: Department of Nuclear Medicine, Leiden University Medical Centre, Leiden, The Netherlands. b.j.van_der_veen@lumc.nl
authors: Berlinda J
authors: BJ
authors: van der Veen
authors: Imad
authors: I
authors: Al Younis
authors: Nina
authors: N
authors: Ajmone-Marsan
authors: Jos J M
authors: JJ
authors: Westenberg
authors: Jeroen J
authors: JJ
authors: Bax
authors: Marcel P M
authors: MP
authors: Stokkel
authors: Albert
authors: A
authors: de Roos
mesh_terms: D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D012146:Rest; D012189:Retrospective Studies; D013312:Stress, Physiological; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging* / Q000503:physiopathology