title: Correlation of cone biopsy with findings at radical hysterectomy and use of adjuvant radiation therapy.
abstract: OBJECTIVE
  To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy.
  
  
  METHODS
  We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation.
  
  
  RESULTS
  A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy.
  
  
  CONCLUSIONS
  Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.
authors: UT Southwestern Medical Center, Department of Ob/Gyn, Division of Gynecologic Oncology, Dallas, TX 75390, USA. Todd.boren@utsouthwestern.edu
authors: Todd P
authors: TP
authors: Boren
authors: Kelley
authors: K
authors: Carrick
authors: Siobhan M
authors: SM
authors: Kehoe
authors: Jayanthia
authors: J
authors: Lea
authors: David S
authors: DS
authors: Miller
authors: Debra L
authors: DL
authors: Richardson
mesh_terms: D000328:Adult; D000368:Aged; D059186:Chemoradiotherapy, Adjuvant; D019092:Conization; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*