title: A single dose of armodafinil significantly promotes vigilance 11 hours post-dose.
abstract: OBJECTIVE
  This study was conducted to test the ability of armodafinil to promote vigilance among air traffic control operators 8 to 11 hours post-dose.
  
  
  METHODS
  Forty-eight U.S. Naval air traffic control students were assigned to one of two groups, 150 mg dose of armodafinil or placebo. At 8:00 a.m., participants were administered armodafinil or a placebo, after which they completed a standard work day. Participants returned at 3:45 p.m. to complete the 4-hour performance portion of the study, where they performed the psychomotor vigilance task.
  
  
  RESULTS
  The analysis showed a significant difference in vigilance between the armodafinil group and placebo (p < 0.05). Psychomotor vigilance task data revealed that participants receiving a 150 mg dose of armodafinil experienced significantly fewer lapses of attention compared to the control group.
  
  
  CONCLUSIONS
  These results justify additional investigation into the efficacy of armodafinil to promote sustained vigilance in military operational settings where fatigue-related performance decrements are especially problematic.
authors: Naval Aerospace Medical Research Laboratory, 280 Fred Bauer Street Building 1811, Pensacola, FL 32508, USA.
authors: Jeffrey B
authors: JB
authors: Phillips
authors: Rita G
authors: RG
authors: Simmons
authors: Richard D
authors: RD
authors: Arnold
mesh_terms: D000293:Adolescent; D000328:Adult; D000337:Aerospace Medicine; D001143:Arousal; D001288:Attention; D001559:Benzhydryl Compounds / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008889:Military Personnel; D000077408:Modafinil; D011597:Psychomotor Performance; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil