title: [Bone and calcium update; bone research update. Role of steroid hormones in regulation of the epigenesis].
abstract: Fat-soluble ligands like steroid hormones exert their actions through nuclear receptor-mediated transcriptional controls. Nuclear receptors are hormone-dependent transcription factors, and their ligand-dependent function is facilitated by transcriptional co-regulators, that were initially considered to bridge nuclear receptors with transcription initiation complex. However, recent progress in epigenome and chromatin research has uncovered that hormone-dependent transcriptional controls by nuclear receptors require a number of epigenetic/transcriptional co-regurators facilitating chromatin reorganization.
authors: IMCB, The University of Tokyo, Japan.
authors: Shigeaki
authors: S
authors: Kato
mesh_terms: D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D004268:DNA-Binding Proteins; D044127:Epigenesis, Genetic; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D012739:Gonadal Steroid Hormones; D018160:Receptors, Cytoplasmic and Nuclear