title: Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data.
abstract: BACKGROUND
  Psychotic conditions and especially schizophrenia, have been associated with increased morbidity and mortality. Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network.
  
  
  METHODS
  Hazard ratios are presented resulting from frailty models to assess the risk of subsequent somatic disease after a diagnosis of psychosis compared to people without psychosis matched on practice, age and gender. Diseases studied are cancer, physical trauma, diabetes mellitus, gastrointestinal disorders, joint disorders, irritable bowel syndrome, general infections, metabolic disorders other than diabetes, hearing and vision problems, anemia, cardiovascular disease, alcohol abuse, lung disorders, mouth and teeth problems, sexually transmitted diseases.
  
  
  RESULTS
  Significant higher risks after a diagnosis of psychosis were found for the emergence of diabetes, physical trauma, gastrointestinal disorders, alcohol abuse, chronic lung disease and teeth and mouth problems. With regard to diabetes, by including the type of antipsychotic medication it is clear that the significant overall effect was largely due to the use of atypical antipsychotic medication. No significant higher risk was seen for cancer, joint conditions, irritable bowel syndrome, general infections, other metabolic conditions, hearing/vision problems, anaemia, cardiovascular disease or diabetes, in case no atypical antipsychotic medication was used.
  
  
  CONCLUSIONS
  Significantly higher morbidity rates for some somatic conditions in patients with psychosis are apparent. People with a diagnosis of psychosis benefit from regular assessments for the emergence of somatic disorders and risk factors, including diabetes in case of atypical antipsychotic medication.
authors: Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium. carla.truyers@med.kuleuven.be
authors: Carla
authors: C
authors: Truyers
authors: Frank
authors: F
authors: Buntinx
authors: Jan
authors: J
authors: De Lepeleire
authors: Marc
authors: M
authors: De Hert
authors: Ruud
authors: R
authors: Van Winkel
authors: Bert
authors: B
authors: Aertgeerts
authors: Stefaan
authors: S
authors: Bartholomeeusen
authors: Emmanuel
authors: E
authors: Lesaffre
mesh_terms: D001530:Belgium; D015331:Cohort Studies; D005260:Female; D058006:General Practice; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors