title: Five new furostanol saponins from the rhizomes of Tupistra chinensis.
abstract: Five new furostanol saponins (1-5), together with three known compounds (6-8) were obtained from the n-butanol soluble fraction of ethanol extract from Tupistra chinensis. Their structures were determined on the basis of chemical methods and spectral data. The isolated compounds were tested in vitro for their cytotoxic activities against the A549, HepG 2 and Caski cancer cell lines. Among them, compounds 6, 7, and 8 showed cytotoxicity against A549 cancer cell lines with IC(50) values of 6.6, 6.7 and 29.1 μM, respectively.
authors: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, PR China.
authors: Cheng-Xiong
authors: CX
authors: Liu
authors: Zhi-Yong
authors: ZY
authors: Guo
authors: Yan-Hong
authors: YH
authors: Xue
authors: Jun
authors: J
authors: Cheng
authors: Nian-Yu
authors: NY
authors: Huang
authors: Yuan
authors: Y
authors: Zhou
authors: Fan
authors: F
authors: Cheng
authors: Kun
authors: K
authors: Zou
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D012503:Saponins