title: Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities.
abstract: This study sought to investigate late-onset hypogonadism (LOH) in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms (AMS) scale and androgen deficiency in aging males (ADAM) questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors (total testosterone (TT), free testosterone (fT), sex hormone-binding globulin (SHBG) and bioavailability of testosterone (Bio-T)). There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results: TT was not related to aging (P>0.05); levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.
authors: Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
authors: Kai
authors: K
authors: Sun
authors: Guo-Qing
authors: GQ
authors: Liang
authors: Xiang-Feng
authors: XF
authors: Chen
authors: Ping
authors: P
authors: Ping
authors: Wen-Liang
authors: WL
authors: Yao
authors: Shi-Jun
authors: SJ
authors: Zhang
authors: Bo
authors: B
authors: Wang
authors: Ying-Hao
authors: YH
authors: Sun
authors: Zheng
authors: Z
authors: Li
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000375:Aging / Q000097:blood; D002681:China / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone