title: Successful pregnancy complicated by persistent pneumothorax in a patient with lymphangioleiomyomatosis (LAM) on sirolimus.
abstract: We report a successful pregnancy in a patient with longstanding LAM on treatment with sirolimus. During temporary discontinuation fo sirolimus in early pregnancy, lung function declined but recovered after resumption of sirolimus. Pregnancy was complicated by a persistent pneumothorax which was treated surgically postnatally. The child has had a normal development despite exposure to low dose sirolimus intermittently during early embryonal and mid-fetal life.
authors: Klinik für Kardiologie und Pneumologie, Klinikum Esslingen, Esslingen; 2Lungenfacharztpraxis, Esslingen. m.faehling@klinikum-es.de
authors: M
authors: M
authors: Faehling
authors: S
authors: S
authors: Frohnmayer
authors: M
authors: M
authors: Leschke
authors: B
authors: B
authors: Trinajstic-Schulz
authors: J
authors: J
authors: Weber
authors: F
authors: F
authors: Liewald
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D050498:Live Birth; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D018192:Lymphangioleiomyomatosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011859:Radiography; D020123:Sirolimus / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D020123:Sirolimus