title: Human GSTs polymorphisms in the Hakka population of south China and their associations with family history of several chronic diseases.
abstract: OBJECTIVE
  To investigate the associations of genetic polymorphisms in GSTs genes of the Hakka population of south China with family histories of certain chronic diseases.
  
  
  METHODS
  Five hundred and thirty-nine healthy Hakka natives of Meizhou city of Guangdong province in south China were involved. The genotypes of GSTM1, GSTT1, GSTP1, GSTM3, and GSTA1 were determined using PCR and restriction fragment length polymorphism analysis. The observed polymorphisms were analyzed by Chi-square and Hardy-Weinberg equilibrium tests. Logistic regression analysis was used to determine the associations of the distributions of GST genotypes with family history of certain chronic diseases.
  
  
  RESULTS
  The distributions of polymorphisms in GSTP1, GSTM3, and GSTA1 conformed to the Hardy-Weinberg equilibrium. Compared to the Cantonese, the Hakka had a lower distribution of the GSTM3 deletion genotype (3.15% vs. 11.9%). A weak association was observed between the GSTM1 genetic polymorphism and family history of hypertension. Alcohol drinkers had a higher frequency of the null-GSTM1 genotype, while smokers had a higher frequency of a variant GSTP1 genotype.
  
  
  CONCLUSIONS
  The results suggest that the Hakka is a special and distinctive Han Chinese ethnic group with different GSTs genetic polymorphisms. Smoking and drinking might be related to the distribution of GST genotypes.
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 510300, Guangdong, China.
authors: ShangXia
authors: S
authors: Pan
authors: XingFen
authors: X
authors: Yang
authors: LinQing
authors: L
authors: Yang
authors: Qing
authors: Q
authors: Wei
authors: Ying
authors: Y
authors: Yang
authors: GuangNing
authors: G
authors: Xu
authors: ZhongNing
authors: Z
authors: Lin
authors: JunMing
authors: J
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012907:Smoking / Q000235:genetics; D055815:Young Adult
chemical_list: D005982:Glutathione Transferase