title: No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese.
abstract: The Met66 allele of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been reported to be associated with anorexia nervosa (AN), and also lower minimum body mass index (BMI) and higher harm avoidance in AN. We genotyped the Val66Met polymorphism (rs6265) in 689 AN cases and 573 control subjects. There were no significant differences in the genotype or allele frequencies of the Val66Met between AN and control subjects (allele wise, odds ratio = 0.920, 95% CI 0.785-1.079, P = 0.305). No difference was found in minimum BMIs related to Val66Met in AN (one-way ANOVA, P > 0.05). Harm avoidance scores on the Temperament and Character Inventory were lower in the Met66 allele carriers (P = 0.0074) contrary to the previous report. Thus we were unable to replicate the previous findings that the Met66 allele of the BDNF is associated with AN and that the minimum BMI is lower or the harm avoidance score is higher in AN patients with the Met66 allele.
authors: Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. ando-t@ncnp.go.jp
authors: Tetsuya
authors: T
authors: Ando
authors: Toshio
authors: T
authors: Ishikawa
authors: Mari
authors: M
authors: Hotta
authors: Tetsuro
authors: T
authors: Naruo
authors: Kenjiro
authors: K
authors: Okabe
authors: Toshihiro
authors: T
authors: Nakahara
authors: Masato
authors: M
authors: Takii
authors: Keisuke
authors: K
authors: Kawai
authors: Takashi
authors: T
authors: Mera
authors: Chiemi
authors: C
authors: Nakamoto
authors: Michiko
authors: M
authors: Takei
authors: Chikara
authors: C
authors: Yamaguchi
authors: Toshihiko
authors: T
authors: Nagata
authors: Yuri
authors: Y
authors: Okamoto
authors: Kazuyoshi
authors: K
authors: Ookuma
authors: Masanori
authors: M
authors: Koide
authors: Takao
authors: T
authors: Yamanaka
authors: Shiho
authors: S
authors: Murata
authors: Naho
authors: N
authors: Tamura
authors: Nobuo
authors: N
authors: Kiriike
authors: Yuhei
authors: Y
authors: Ichimaru
authors: Gen
authors: G
authors: Komaki
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D000856:Anorexia Nervosa / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D010555:Personality Inventory; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor