title: Non-IgA mesangioproliferative glomerulonephritis: a benign entity?
abstract: BACKGROUND
  Non-IgA mesangioproliferative glomerulonephritis is a well recognized but less studied entity. The clinical manifestations, treatment response and long-term outcome have not been clearly defined.
  
  
  METHODS
  This single-centre study included patients with biopsy-proven non-IgA mesangioproliferative glomerulonephritis who had been on regular follow-up for >3 years. Their clinical features at presentation, response to therapy and long-term renal outcome are addressed in this study.
  
  
  RESULTS
  Nephrotic syndrome developed in 51 of 57 patients (89.4%). The majority of them--34 of 51(80%)--were steroid sensitive and had either infrequent or no relapse. However, steroid-dependent nephrotic syndrome occurred in eight patients (15.6%), while steroid resistance occurred in nine patients (17.6 %). Thirteen patients developed chronic kidney disease (CKD) with three progressing to end-stage renal disease, three to CKD Stage 4 and seven to CKD Stage 3.
  
  
  CONCLUSIONS
  Non-IgA mesangioproliferative glomerulonephritis is a disease, which is not benign, and is associated with significant treatment-related morbidity.
authors: Department of Nephrology, IPGMER and SSKM Hospital, Kolkata, India. rajesh.waikhom@gmail.com
authors: Rajesh
authors: R
authors: Waikhom
authors: Dipankar
authors: D
authors: Sarkar
authors: Krishna
authors: K
authors: Patil
authors: Rajendra
authors: R
authors: Pandey
authors: Sanjay
authors: S
authors: Dasgupta
authors: Jayaprada
authors: J
authors: Jadhav
authors: Anila
authors: A
authors: Abraham
mesh_terms: D000328:Adult; D001706:Biopsy; D002648:Child; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D013256:Steroids / Q000009:adverse effects
chemical_list: D007070:Immunoglobulin A; D013256:Steroids