title: Acute running stimulates hippocampal dopaminergic neurotransmission in rats, but has no influence on brain-derived neurotrophic factor.
abstract: Hippocampal brain-derived neurotrophic factor (BDNF) protein is increased with exercise in rats. Monoamines seem to play a role in the regulation of BDNF, and monoamine neurotransmission is known to increase with exercise. The purpose of this study was to examine the influence of acute exercise on monoaminergic neurotransmission and BDNF protein concentrations. Hippocampal microdialysis was performed in rats that were subjected to 60 min of treadmill running at 20 m/min or rest. Two hours postexercise, the rats were killed, and the hippocampus was dissected. In experiments without microdialysis, hippocampus and serum samples were collected immediately after exercise. Exercise induced a twofold increase in hippocampal dopamine release. Noradrenaline and serotonin release were not affected. Hippocampal BDNF levels were not influenced, whether they were measured immediately or 2 h after the exercise protocol. Serum BDNF levels did not change either, but serum BDNF was negatively correlated to peripheral corticosterone concentrations, indicating a possible inhibitory reaction to the stress of running. Sixty minutes of exercise enhances dopamine release in the hippocampus of the rat in vivo. However, this increase is not associated with changes in BDNF protein levels immediately nor 2 h after the acute exercise bout. An increased corticosterone level might be the contributing factor for the absence of changes in BDNF.
authors: Department of Human Physiology and Sports Medicine, Faculty of Physical Education and Physical Therapy, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
authors: Maaike
authors: M
authors: Goekint
authors: Inge
authors: I
authors: Bos
authors: Elsa
authors: E
authors: Heyman
authors: Romain
authors: R
authors: Meeusen
authors: Yvette
authors: Y
authors: Michotte
authors: Sophie
authors: S
authors: Sarre
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012420:Running / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012701:Serotonin; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine