title: Preclinical studies on histone deacetylase inhibitors as therapeutic reagents for endometrial and ovarian cancers.
abstract: Histone deacetylases (HDACs) remove acetyl groups from lysine residues of histones and the deacetylation allows for tighter electrostatic interactions between DNA and histones, leading to a more compact chromatin conformation with limited access for transactivators and the suppression of transcription. HDAC mRNA and protein overexpression was observed in endometrial and ovarian cancers. Numerous in vitro studies have shown that HDAC inhibitors, through their actions on histone and nonhistone proteins, are able to reactivate the tumor suppressor genes, inhibit cell cycle progression and induce cell apoptosis in endometrial and ovarian cancer cell cultures. Results from mouse xenograft models also demonstrated the potency of HDAC inhibitors as anticancer reagents when used as single agent or in combination with classical chemotherapy drugs.
authors: Department of Biomedical Science, Mercer University School of Medicine at Savannah, Savannah, GA 31404, USA.
authors: Brahma N
authors: BN
authors: Singh
authors: Hongyuan
authors: H
authors: Zhou
authors: Jinping
authors: J
authors: Li
authors: Tracy
authors: T
authors: Tipton
authors: Bin
authors: B
authors: Wang
authors: Guo
authors: G
authors: Shao
authors: E Nickolas
authors: EN
authors: Gilbert
authors: Qiang
authors: Q
authors: Li
authors: Shi-Wen
authors: SW
authors: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases