title: The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea.
abstract: BACKGROUND
  This study was conducted to evaluate the therapeutic performance of a new auto Servo Ventilation device (Philips Respironics autoSV Advanced) for the treatment of complex central sleep apnea (CompSA). The features of autoSV Advanced include an automatic expiratory pressure (EPAP) adjustment, an advanced algorithm for distinguishing open versus obstructed airway apnea, a modified auto backup rate which is proportional to subject's baseline breathing rate, and a variable inspiratory support. Our primary aim was to compare the performance of the advanced servo-ventilator (BiPAP autoSV Advanced) with conventional servo-ventilator (BiPAP autoSV) in treating central sleep apnea (CSA).
  
  
  METHODS
  A prospective, multicenter, randomized, controlled trial.
  
  
  METHODS
  Five sleep laboratories in the United States.
  
  
  METHODS
  Thirty-seven participants were included.
  
  
  RESULTS
  All subjects had full night polysomnography (PSG) followed by a second night continuous positive airway pressure (CPAP) titration. All had a central apnea index ≥ 5 per hour of sleep on CPAP. Subjects were randomly assigned to 2 full-night PSGs while treated with either the previously marketed autoSV, or the new autoSV Advanced device. The 2 randomized sleep studies were blindly scored centrally. Across the 4 nights (PSG, CPAP, autoSV, and autoSV Advanced), the mean ± 1 SD apnea hypopnea indices were 53 ± 23, 35 ± 20, 10 ± 10, and 6 ± 6, respectively; indices for CSA were 16 ± 19, 19 ± 18, 3 ± 4, and 0.6 ± 1. AutoSV Advanced was more effective than other modes in correcting sleep related breathing disorders.
  
  
  CONCLUSIONS
  BiPAP autoSV Advanced was more effective than conventional BiPAP autoSV in the treatment of sleep disordered breathing in patients with CSA.
authors: University of Cincinnati College of Medicine, Medical Director Sleepcare Diagnostics, Cincinnati, OH 45040, USA. javaheri@snorenomore.com
authors: Shahrokh
authors: S
authors: Javaheri
authors: Mark G
authors: MG
authors: Goetting
authors: Rami
authors: R
authors: Khayat
authors: Paul E
authors: PE
authors: Wylie
authors: James L
authors: JL
authors: Goodwin
authors: Sairam
authors: S
authors: Parthasarathy
mesh_terms: D045422:Continuous Positive Airway Pressure; D045853:Exhalation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011175:Positive-Pressure Respiration / Q000295:instrumentation* / Q000379:methods; D020182:Sleep Apnea, Central / Q000503:physiopathology / Q000628:therapy*