title: Prognostic value of transforming growth factor beta 1 [TGF-β1] and matrix metalloproteinase 9 [MMP-9] in oral squamous cell carcinoma.
abstract: OBJECTIVE
  The prognostic value of MMP-9 and TGF-β1 in oral squamous cell carcinoma (OSCC) is not clear. This study aimed to assess this subject.
  
  
  METHODS
  After immunohistochemistry staining of 48 OSCC biopsies with MMP-9 and TGF-β1 markers, marker expression in the stroma was estimated, and the correlations with OSCC prognosis determinants were analyzed (α = 0.05).
  
  
  RESULTS
  Mode of invasion was associated with metastasis (rho = 0.449, p = 0.008). MMP-9 was positively associated with metastasis and mode of invasion. TGF-β1 was negatively correlated to tumor histologic grade but was positively associated with metastasis.
  
  
  CONCLUSIONS
  Unlike TGF-β1, MMP-9 might be useful for prognosis determination.
authors: Department of Oral Pathology, Dental School, Qazvin University of Medical Sciences, Iran.
authors: Maryam
authors: M
authors: Elahi
authors: Vahid
authors: V
authors: Rakhshan
authors: Nasim Taghavi
authors: NT
authors: Ghasemian
authors: Mohamad
authors: M
authors: Moshref
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D053773:Transforming Growth Factor beta1 / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D053773:Transforming Growth Factor beta1; D020780:Matrix Metalloproteinase 9