title: Outcomes of a cancer clinical trial matching service.
abstract: The American Cancer Society (ACS) and Coalition of Cancer Cooperative Groups (CCCG) provide a clinical trial (CT) information/matching/eligibility service (Clinical Trials Matching Service [CTMS]). Patients' demographic and clinical data, enrollment status, and self-reported barriers to CT participation were analyzed to assess enrollment rates and determinants of enrollment. During 3 years beginning October 1, 2007, the CTMS served 6,903 patients via the ACS call center. Among the 1,987 patients with follow-up information on enrollment, 219 (11.0%) enrolled in a CT; 48 of these 219 enrollees chose a CT they found via the CTMS. Patients were less likely to enroll if they had poor ECOG performance status (P = 0.032); were African American (P = 0.0003), were uninsured or had Medicaid coverage (P = 0.024), or had lower stage disease (P = 0.018). Enrollment varied by trial type/cancer site/system (P = .026). Several barriers significantly predicted nonenrollment. Broader availability of a CTMS might help improve patient participation in cancer clinical trials.
authors: Department of Health Promotion, American Cancer Society, Atlanta, GA 30303, USA. Ted.gansler@cancer.org
authors: Ted
authors: T
authors: Gansler
authors: Man
authors: M
authors: Jin
authors: Joseph
authors: J
authors: Bauer
authors: Katie
authors: K
authors: Dahlquist
authors: Larissa
authors: L
authors: Tis
authors: Katherine
authors: K
authors: Sharpe
authors: Robert
authors: R
authors: Comis
authors: Kimberly
authors: K
authors: Naples
authors: James
authors: J
authors: Kepner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D005260:Female; D006297:Health Services Accessibility; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008913:Minority Groups / Q000706:statistics & numerical data*; D009369:Neoplasms / Q000517:prevention & control*; D010358:Patient Participation; D018579:Patient Selection; D011379:Prognosis; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult