title: [Expression of psoriasin in mycosis fungoides and its significance].
abstract: OBJECTIVE
  To investigate the role of psoriasin in mycosis fungoides.
  
  
  METHODS
  Psoriasin protein expressions in normal skin tissues and mycosis fungoides tissues were detected by immunohistochemistry.
  
  
  RESULTS
  Psoriasin protein was not expressed in normal skin tissues. In 21 mycosis fungoides tissue specimens, psoriasin was expressed in the stratum corneum and stratum spinosum but not in the stratum basale, with a positivity rate of 90.5% in these specimens.  Psoriasin expression was significantly higher in mycosis fungoidesa tissues than in normal tissues (P<0.001).
  
  
  CONCLUSIONS
  Psoriasin may play a role in the pathogenesis of mycosis fungoides by chemotaxis of CD4+ T lymphocytes.
authors: Department of Dermatology, the Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi an 710004, China. xulei5270@sina.com
authors: Lei
authors: L
authors: Xu
authors: Wei-hui
authors: WH
authors: Zeng
authors: Yan
authors: Y
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000209:etiology / Q000378:metabolism*; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D055815:Young Adult
chemical_list: D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human