title: Calcium carbonate nanoparticles: synthesis, characterization and biocompatibility.
abstract: The synthesis of nanoparticles and their functionalization to effectively utilize them in biological applications including drug delivery is currently a challenge. Calcium carbonate among many other inorganic nanosized particles offers promising results for such applications. We have synthesized calcium carbonate nanoparticles using polymer mediated growth technique, where one of the ions bound within polymer matrix and the other diffuses and reacts to form desired compound. The synthesized nanoparticles are characterized using X-ray diffraction, Scanning Electron Microscopy and spectroscopic techniques such as Fourier-Transform Infra-red spectroscopy and UV-Vis spectroscopy. The diameter of the calcium carbonate nanoparticles is estimated to be 39.8 nm and their biocompatibility studies showed no significant induction of oxidative stress or cell death even at higher concentrations (50 microg) upon exposure to HeLa and LE cells. Here, we report that the synthesized calcium carbonate nanosized particles using polymer mediated growth technique are biocompatible and can be safely used for biomedical applications.
authors: Molecular Toxicology Laboratory, Center for Biotechnology and Biomedical Sciences, Norfolk State University, 700 Park Avenue, Norfolk, VA 23504, USA.
authors: Santoshkumar
authors: S
authors: Biradar
authors: Prabakaran
authors: P
authors: Ravichandran
authors: Ramya
authors: R
authors: Gopikrishnan
authors: Virupaxi
authors: V
authors: Goornavar
authors: Joseph C
authors: JC
authors: Hall
authors: Vani
authors: V
authors: Ramesh
authors: Sudhakar
authors: S
authors: Baluchamy
authors: Robert B
authors: RB
authors: Jeffers
authors: Govindarajan T
authors: GT
authors: Ramesh
mesh_terms: D001672:Biocompatible Materials; D002119:Calcium Carbonate / Q000138:chemical synthesis* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008855:Microscopy, Electron, Scanning; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D002119:Calcium Carbonate