title: Polymorphisms and noncardioembolic stroke in three case-control studies.
abstract: BACKGROUND
  Gene variants associated with disease could reveal novel mechanisms. We searched for single nucleotide polymorphisms (SNPs) associated with noncardioembolic stroke (nonCES).
  
  
  METHODS
  We tested 24,926 SNPs in or near genes for association with nonCES in the Vienna Study (551 cases, 815 controls) and then evaluated the associated SNPs in the UCSF-CC Study (570 cases, 1,604 controls) first in pooled DNA samples and then in individual DNA samples. We then asked whether the risk alleles of the SNPs associated with increased risk in both studies were also associated with increased risk of nonCES in the German Study (728 cases, 1,041 controls).
  
  
  RESULTS
  Six of the 46 SNPs that were associated with nonCES in both the Vienna and the UCSF-CC Studies were also associated with nonCES in the German Study: rs362277 in HTT (OR 1.39, 90% CI 1.12-1.71), rs2924914 near CSMD1 (OR 1.22, 90% CI 1.04-1.43), rs1264352 near DDR1 (OR 1.20, 90% CI 1.02-1.41), rs544115 in NEU3 (OR 1.63, 90% CI 1.02-2.62), rs12481805 in UMODL1 (OR 1.31, 90% CI 1.01-1.81), and rs2857595 near NCR3 (OR 1.15, 90% CI 1.00-1.32). Accounting for multiple testing of 46 SNPs, these 6 SNPs had a false discovery rate of 0.69.
  
  
  CONCLUSIONS
  Some of the 6 SNPs may be associated with nonCES but most may be false positives. These 6 SNPs merit investigation in additional nonCES study populations.
authors: Celera, Alameda, CA 94502, USA. may.luke@celera.com
authors: May M
authors: MM
authors: Luke
authors: Klaus
authors: K
authors: Berger
authors: Charles M
authors: CM
authors: Rowland
authors: Joseph J
authors: JJ
authors: Catanese
authors: Carmen H
authors: CH
authors: Tong
authors: David A
authors: DA
authors: Ross
authors: Veronica
authors: V
authors: Garcia
authors: Gregor
authors: G
authors: Kuhlenbaeumer
authors: E Bernd
authors: EB
authors: Ringelstein
authors: Clive R
authors: CR
authors: Pullinger
authors: Mary J
authors: MJ
authors: Malloy
authors: Prakash
authors: P
authors: Deedwania
authors: Stephen G
authors: SG
authors: Ellis
authors: John P
authors: JP
authors: Kane
authors: James J
authors: JJ
authors: Devlin
authors: Wolfgang
authors: W
authors: Lalouschek
authors: Christine
authors: C
authors: Mannhalter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001317:Austria; D002135:Calcium-Binding Proteins / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D000070819:Discoidin Domain Receptor 1; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D016015:Logistic Models; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000235:genetics; D009439:Neuraminidase / Q000235:genetics; D016017:Odds Ratio; D009820:Ohio; D020641:Polymorphism, Single Nucleotide; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D012495:San Francisco; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D020521:Stroke / Q000235:genetics*; D025521:Tumor Suppressor Proteins
chemical_list: C477880:CSMD1 protein, human; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C431710:NCR3 protein, human; D055628:Natural Cytotoxicity Triggering Receptor 3; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D025521:Tumor Suppressor Proteins; C488198:UMODL1 protein, human; C092030:DDR1 protein, human; D000070819:Discoidin Domain Receptor 1; D020794:Receptor Protein-Tyrosine Kinases; C465436:Neu3 protein, human; D009439:Neuraminidase