title: Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy.
abstract: A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.
authors: Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hsinchu 30013, Taiwan.
authors: Chian-Hui
authors: CH
authors: Lai
authors: Yu-Chuan
authors: YC
authors: Lin
authors: Fong-In
authors: FI
authors: Chou
authors: Chien-Fu
authors: CF
authors: Liang
authors: En-Wei
authors: EW
authors: Lin
authors: Yung-Jen
authors: YJ
authors: Chuang
authors: Chun-Cheng
authors: CC
authors: Lin
mesh_terms: D001880:Boranes / Q000737:chemistry*; D001895:Boron / Q000008:administration & dosage* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005690:Galactose / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy
chemical_list: D001880:Boranes; D050091:Dendrimers; D001895:Boron; D005690:Galactose