title: Enantioselective preparation of P-chiral phosphine oxides.
abstract: A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides.
authors: Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
authors: Harry
authors: H
authors: Adams
authors: Rebecca C
authors: RC
authors: Collins
authors: Simon
authors: S
authors: Jones
authors: Christopher J A
authors: CJ
authors: Warner