title: Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases.
abstract: Oxidative stress plays an important part in the appearance and development of cardiovascular diseases. In this context, overproduction of reactive oxygen species leads to deregulation of metabolic pathways, such as cell proliferation or inflammation, which interferes with the homeostasis of vascular endothelium. Oxidative stress can decrease the bioavailability of nitric oxide (*NO) in vessels. This decrease is highly associated with endothelial dysfunction. The "French paradox" is a phenomenon that associates a diet rich in saturated fatty acids and a moderate consumption of wine to a low prevalence of cardiovascular diseases. During the past 10 years, the beneficial effects of wine on cardiovascular diseases have been attributed to the actions of resveratrol and other polyphenols. One of the mechanisms involved in these beneficial effects is the capacity of resveratrol and some other stilbene derivatives to maintain sufficient *NO bioavailability in vascular endothelium. This review presents the latest findings on the molecular effects of resveratrol and other stilbene derivatives on the various actors that modulate *NO bioavailability during oxidative stress.
authors: EA 4466 Stress Cellulaire, Physiopathologie, Stratégies nutritionnelles et thérapeutiques innovantes, Université Paris Descartes, Sorbonne Paris Cité, UFR des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75006 Paris, France. mathieu@newmed.fr
authors: Matthieu
authors: M
authors: Frombaum
authors: Solenn
authors: S
authors: Le Clanche
authors: Dominique
authors: D
authors: Bonnefont-Rousselot
authors: Didier
authors: D
authors: Borderie
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001682:Biological Availability; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D004036:Diet, Atherogenic; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D005227:Fatty Acids; D006801:Humans; D051379:Mice; D009569:Nitric Oxide / Q000819:agonists / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017382:Reactive Oxygen Species; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000378:metabolism*; D014920:Wine
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D059808:Polyphenols; D017382:Reactive Oxygen Species; D013267:Stilbenes; D009569:Nitric Oxide; D001120:Arginine; D000077185:Resveratrol