title: Association of angiotensin converting enzyme (insertion/deletion) gene polymorphism with essential hypertension in northern Indian subjects.
abstract: OBJECTIVE
  Essential hypertension is a multifactorial disease in which genetic and environmental factors play an important role. The renin-angiotensin system (RAS) is known to play a critical role in the homeostasis of blood pressure. Angiotensin-I converting enzyme (ACE) is a significant component of RAS, and an insertion/deletion (I/D) polymorphism in its gene has been implicated in predisposition to hypertension. The purpose of the current study is to investigate the association of I/D polymorphism of the ACE gene with essential hypertension in northern Indians.
  
  
  METHODS
  Two hundred twenty-two patients with essential hypertension and 252 controls were recruited for the study. DNA samples were isolated from peripheral blood by using a kit. Polymerase chain reaction was used for genotyping.
  
  
  RESULTS
  All the genotypes and allele distribution in study subjects were in the Hardy-Weinberg equilibrium. There was a significant difference in the distribution of DD, II, and ID genotypes of ACE polymorphism in patients and controls. In the subjects having an I allele, the odds ratio is 2.08 [1.6-2.58] at 95% confidence interval, thus suggesting an association of ACE I/D gene polymorphism with essential hypertension.
  
  
  CONCLUSIONS
  Our findings suggest that the I allele of ACE I/D polymorphism is associated with essential hypertension in our population.
authors: Dr BR Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, India. kamna_srivastava@hotmail.com
authors: Kamna
authors: K
authors: Srivastava
authors: Ruchi
authors: R
authors: Sundriyal
authors: Prakash C
authors: PC
authors: Meena
authors: Jagriti
authors: J
authors: Bhatia
authors: Rajiv
authors: R
authors: Narang
authors: Daman
authors: D
authors: Saluja
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007194:India; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D044465:White People / Q000235:genetics
chemical_list: D007703:Peptidyl-Dipeptidase A