title: Pyrenes and pyrendiones from Uvaria lucida.
abstract: A chemical investigation of the chloroform extract of the roots of Uvaria ludida Benth. (Annonaceae), an important African traditional medicine, led to the isolation of six new compounds; three pyrenes, 2-hydroxy-1,8-dimethoxypyrene (1), 8-methoxy-1,2-methylenedioxypyrene (2), and 7-hydroxy-8-methoxy-1,2-methylenedioxypyrene (3), two pyrenediones, 2-hydroxy-1,8-pyrenedione (4) and 2-methoxy-1,8-pyrenedione (5), and a sesquiterpene, (-)-10-oxo-isodauc-3-en-15-oic acid (6), together with eight known compounds (7-14). The structural elucidation by spectroscopic studies of the compounds isolated is described. While pyrenes did not exhibit strong cytotoxicity against human promyelocytic leukemia HL-60 cells, pyrenediones showed strong cytotoxicity. The IC(50) of 4 was 70 ng mL(-1), which was close to that of etoposide (IC(50) = 60 ng mL(-1)).
authors: Department of Natural Medicinal Chemistry, Kobe pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. moriyasu@kobepharma-u.ac.jp
authors: Masataka
authors: M
authors: Moriyasu
authors: Sousuke
authors: S
authors: Takeuchi
authors: Momoyo
authors: M
authors: Ichimaru
authors: Noriyshi
authors: N
authors: Nakatani
authors: Yumi
authors: Y
authors: Nishiyama
authors: Atsushi
authors: A
authors: Kato
authors: Simon G
authors: SG
authors: Mathenge
authors: Francis D
authors: FD
authors: Juma
authors: Patrick B
authors: PB
authors: ChaloMutiso
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D011721:Pyrenes / Q000737:chemistry* / Q000494:pharmacology*; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011721:Pyrenes