title: New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell.
abstract: BACKGROUND
  Solid lipid nanoparticles (SLNs) are colloidal carrier systems which provide controlled-release profiles for many substances. In this study, we prepared aqueous dispersions of lipid nanoparticles using a modified, pH-sensitive derivative of phosphatidylethanolamine.
  
  
  METHODS
  SLNs were prepared using polysorbate 80 as the surfactant and tripalmitin glyceride and N-glutaryl phosphatidylethanolamine as the lipid components. Particle size, polydispersity index, and zeta potential were examined by photon correlation spectroscopy. Morphological evaluation was performed using scanning electron microscopy, atomic force microscopy, and differential scanning calorimetry.
  
  
  RESULTS
  Photon correlation spectroscopy revealed a particle hydrodynamic diameter of 165.8 nm and zeta potential of -41.6.0 mV for the drug-loaded nanoparticles. Atomic force microscopy investigation showed the nanoparticles to be 50-600 nm in length and 66.5 nm in height. Differential scanning calorimetry indicated that the majority of SLNs possessed less ordered arrangements of crystals compared with corresponding bulk lipids, which is favorable for improving drug-loading capacity. Drug-loading capacity and drug entrapment efficiency values for the SLNs were 25.32% and 94.32%, respectively.
  
  
  CONCLUSIONS
  The SLNs prepared in this study were able to control the release of triamcinolone acetonide under acidic conditions.
authors: School of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, Kermanshah, Iran.
authors: Soheila
authors: S
authors: Kashanian
authors: Abbas Hemati
authors: AH
authors: Azandaryani
authors: Katayoun
authors: K
authors: Derakhshandeh
mesh_terms: D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008853:Microscopy; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D014222:Triamcinolone Acetonide / Q000493:pharmacokinetics; D014280:Triglycerides / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; C049392:N-glutarylphosphatidylethanolamine; D010714:Phosphatidylethanolamines; D014280:Triglycerides; C005859:tripalmitin; D014222:Triamcinolone Acetonide