title: Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging.
abstract: Amyloid imaging may revolutionize Alzheimer's disease (AD) research and clinical practice but is critically limited by an inadequate correlation between cerebral cortex amyloid plaques and dementia. Also, amyloid imaging does not indicate the extent of neurofibrillary tangle (NFT) spread throughout the brain. Currently, the presence of dementia as well as a minimal brain load of both plaques and NFTs is required for the diagnosis of AD. Autopsy studies suggest that striatal amyloid plaques may be mainly restricted to subjects in higher Braak NFT stages that meet clinicopathological diagnostic criteria for AD. Striatal plaques, which are readily identified by amyloid imaging, might therefore be used to predict the presence of a higher Braak NFT stage and clinicopathological AD in living subjects. This study determined the sensitivity and specificity of striatal plaques for predicting a higher Braak NFT stage and clinicopathological AD in a postmortem series of 211 elderly subjects. Subjects included 87 clinicopathologically classified as non-demented elderly controls and 124 with AD. A higher striatal plaque density score (moderate or frequent) had 95.8% sensitivity, 75.7% specificity for Braak NFT stage V or VI and 85.6% sensitivity, 86.2% specificity for the presence of dementia and clinicopathological AD (National Institute on Aging - Reagan Institute "intermediate" or "high"). Amyloid imaging of the striatum may be useful as a predictor, in living subjects, of Braak NFT stage and the presence or absence of dementia and clinicopathological AD. Validation of this hypothesis will require autopsy studies of subjects that had amyloid imaging during life.
authors: Banner Sun Health Research Institute, Sun City, AZ 85351, USA. thomas.beach@bannerhealth.com
authors: Thomas G
authors: TG
authors: Beach
authors: Lucia I
authors: LI
authors: Sue
authors: Douglas G
authors: DG
authors: Walker
authors: Marwan N
authors: MN
authors: Sabbagh
authors: Geidy
authors: G
authors: Serrano
authors: Brittany N
authors: BN
authors: Dugger
authors: Monica
authors: M
authors: Mariner
authors: Kim
authors: K
authors: Yantos
authors: Jonette
authors: J
authors: Henry-Watson
authors: Glenn
authors: G
authors: Chiarolanza
authors: Jose A
authors: JA
authors: Hidalgo
authors: Leslie
authors: L
authors: Souders
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000032:analysis; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology*; D058225:Plaque, Amyloid / Q000473:pathology*; D011237:Predictive Value of Tests
chemical_list: D000682:Amyloid