title: Trithorax group proteins: switching genes on and keeping them active.
abstract: Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular analysis, they have lived in the shadow of their more famous counterparts, the PcG proteins. Recent advances have improved our understanding of TrxG protein function and demonstrated that the heterogeneous group of TrxG proteins is of critical importance in the epigenetic regulation of the cell cycle, senescence, DNA damage and stem cell biology.
authors: Institut de Génétique Humaine, CNRS, 141, Rue de la Cardonille, 34396 Montpellier Cedex 5, France.
authors: Bernd
authors: B
authors: Schuettengruber
authors: Anne-Marie
authors: AM
authors: Martinez
authors: Nicola
authors: N
authors: Iovino
authors: Giacomo
authors: G
authors: Cavalli
mesh_terms: D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D044127:Epigenesis, Genetic; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004247:DNA