title: Significance of molecular markers in survival prediction of oral squamous cell carcinoma.
abstract: BACKGROUND
  An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for deciding appropriate therapies. The prediction accuracy of prediction models can be improved by using molecular biomarkers. We constructed a nomogram for predicting the survival of patients with OSCC using clinical variables and molecular markers.
  
  
  METHODS
  Protein 53 (p53), insulin-like growth factor II mRNA-binding protein 3 (IMP3), cyclooxygenase 2 (COX2), and HuR were localized immunohistochemistry in 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea.
  
  
  RESULTS
  On univariate and multivariate analysis, the expression of IMP3 was significantly associated with the risk of death. P53 was also significantly associated with survival of OSCC in the case of negative IMP3 and the prediction accuracy was improved by including these 2 factors in the prediction model.
  
  
  CONCLUSIONS
  Survival in OSCC can be predicted more accurately by using biomarkers. The constructed nomogram predicted survival after treatment for an individual patient with OSCC, and it can be practically used as a tool to help decide which adjuvant treatment is most appropriate.
authors: Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, 120-752, Republic of Korea.
authors: Ki-Yeol
authors: KY
authors: Kim
authors: ShengJin
authors: S
authors: Li
authors: Jeong-Dan
authors: JD
authors: Cha
authors: Xianglan
authors: X
authors: Zhang
authors: In-Ho
authors: IH
authors: Cha
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality; D051546:Cyclooxygenase 2 / Q000378:metabolism; D051959:ELAV Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality; D015999:Multivariate Analysis; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism*; D056910:Republic of Korea; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051959:ELAV Proteins; C498780:IGF2BP3 protein, human; D016601:RNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human