title: Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler.
abstract: In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cytotoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan(®). Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan(®). In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan(®). In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.
authors: a Department of Obstetrics and Gynecology , Taipei Medical University Hospital , Taipei , Taiwan, ROC.
authors: Ching-Wen
authors: CW
authors: Chang
authors: Hsiu-O
authors: HO
authors: Ho
authors: Yi-June
authors: YJ
authors: Lo
authors: Sheng-Yang
authors: SY
authors: Lee
authors: You-Ren
authors: YR
authors: Yang
authors: Ming-Thau
authors: MT
authors: Sheu
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D001458:Bandages; D002470:Cell Survival; D003432:Cross-Linking Reagents / Q000737:chemistry; D003764:Dental Materials / Q000138:chemical synthesis / Q000737:chemistry; D004285:Dogs; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005339:Fibrin Foam; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D005881:Gingiva / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology; D005976:Glutaral / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D023421:Models, Animal; D011095:Polyethylenes / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D014081:Tooth Extraction; D014945:Wound Healing
chemical_list: D000779:Anesthetics, Local; D003432:Cross-Linking Reagents; D003764:Dental Materials; D005339:Fibrin Foam; D020100:Hydrogels; D007097:Imines; D011095:Polyethylenes; C505405:poly(ethylene imine); D008012:Lidocaine; D011205:Povidone; D005976:Glutaral