title: Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?
abstract: Foxp3(+) T regulatory cells (Tregs) consisting of natural and induced Treg subsets play a crucial role in the maintenance of immune homeostasis against self-antigen. The actions designed to correct defects in numbers or functions of Tregs may be therapeutic in the treatment of autoimmune diseases. While recent studies demonstrated that natural Tregs are instable and dysfunctional in the inflammatory condition, induced Tregs (iTregs) may have a different feature. Here we review the progress of iTregs, particularly focus on their stability and function in the established autoimmune diseases. The advantage of iTregs as therapeutics used under inflammatory conditions is highlighted. Proper generation and manipulation of iTregs used for cellular therapy may provide a promise for the treatment of many autoimmune and inflammatory diseases.
authors: Medicine Translation Center,  Shanghai East Hospital, Tongji University, Shanghai 200120,  China.
authors: Qin
authors: Q
authors: Lan
authors: Huimin
authors: H
authors: Fan
authors: Valerie
authors: V
authors: Quesniaux
authors: Bernhard
authors: B
authors: Ryffel
authors: Zhongmin
authors: Z
authors: Liu
authors: Song Guo
authors: SG
authors: Zheng
mesh_terms: D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D002454:Cell Differentiation; D017690:Cell Transplantation / Q000379:methods; D051858:Forkhead Transcription Factors / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D007378:Interleukins / Q000276:immunology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000637:transplantation*; D016212:Transforming Growth Factor beta / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D007378:Interleukins; D016212:Transforming Growth Factor beta