title: Hyperglycemic hyperosmolar state associated with low-dose quetiapine treatment in a patient with bipolar disorder.
abstract: There is increasing concern about the development of diabetes mellitus and associated complications in patients administrating second-generation antipsychotics. Previous reports indicate that the risk of quetiapine, although relatively lower, is not negligible. We report a patient with bipolar disorder who, after treating with low-dose quetiapine, develops newly-onset diabetes and hyperglycemic hyperosmolar state. Clinical manifestations and managements of quetiapine-associated diabetes are addressed, and we recommend routine monitoring of serum glucose after initiating quetiapine treatment at any given dose.
authors: Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
authors: Wen-Yin
authors: WY
authors: Chen
authors: Chiao-Chicy
authors: CC
authors: Chen
authors: Galen C L
authors: GC
authors: Hung
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy; D001786:Blood Glucose / Q000187:drug effects; D003920:Diabetes Mellitus / Q000139:chemically induced*; D003987:Dibenzothiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D016903:Drug Monitoring; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D009994:Osmolar Concentration; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate