title: Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination.
abstract: OBJECTIVE
  To evaluate the value of intrauterine insemination (IUI) in controlled ovarian hyperstimulation (COH) among couples with polycystic ovary syndrome (PCOS) and normal semen analysis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University teaching center.
  
  
  METHODS
  PCOS couples with normal semen analysis that underwent COH with IUI or timed intercourse (TIC).
  
  
  METHODS
  COH with clomiphene citrate, letrozole or gonadotropins with or without IUI.
  
  
  METHODS
  Clinical pregnancy rates.
  
  
  RESULTS
  Of a total 265 cycles, 151 cycles were with IUI and 114 others with TIC. No significant difference was found in the overall pregnancy rates between the TIC group (17.5%) and the IUI group (16.6%). Analysis of pregnancy rates according to the type of COH treatments did not demonstrate the advantages of IUI over TIC.
  
  
  CONCLUSIONS
  Compared to timed intercourse, IUI does not increase the pregnancy rate in couples with PCOS and normal semen analysis treated with COH.
authors: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. wiserniv@netvision.net.il
authors: Amir
authors: A
authors: Wiser
authors: Einat
authors: E
authors: Shalom-Paz
authors: Shaune Leigh
authors: SL
authors: Reinblatt
authors: Hananel
authors: H
authors: Holzer
authors: Togas
authors: T
authors: Tulandi
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000627:therapeutic use*; D006062:Gonadotropins / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007315:Insemination, Artificial / Q000009:adverse effects; D000077289:Letrozole; D009570:Nitriles / Q000009:adverse effects / Q000627:therapeutic use; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011792:Quebec; D012189:Retrospective Studies; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects / Q000627:therapeutic use; D012725:Sexual Behavior; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D006062:Gonadotropins; D009570:Nitriles; D020845:Selective Estrogen Receptor Modulators; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole