title: Stress-related noradrenergic activity prompts large-scale neural network reconfiguration.
abstract: Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes. β-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting.
authors: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. erno.hermans@donders.ru.nl
authors: Erno J
authors: EJ
authors: Hermans
authors: Hein J F
authors: HJ
authors: van Marle
authors: Lindsey
authors: L
authors: Ossewaarde
authors: Marloes J A G
authors: MJ
authors: Henckens
authors: Shaozheng
authors: S
authors: Qin
authors: Marlieke T R
authors: MT
authors: van Kesteren
authors: Vincent C
authors: VC
authors: Schoots
authors: Helena
authors: H
authors: Cousijn
authors: Mark
authors: M
authors: Rijpkema
authors: Robert
authors: R
authors: Oostenveld
authors: Guillén
authors: G
authors: Fernández
mesh_terms: D000293:Adolescent; D059331:Adrenergic Neurons / Q000502:physiology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000339:Affect; D001288:Attention; D001341:Autonomic Nervous System / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D059907:Functional Neuroimaging; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008125:Locus Coeruleus / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D009415:Nerve Net / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012463:Saliva / Q000737:chemistry; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology; D055815:Young Adult; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D018377:Neurotransmitter Agents; D011943:Receptors, Adrenergic, beta; D000516:alpha-Amylases; D006854:Hydrocortisone; D009638:Norepinephrine; D008797:Metyrapone