title: A new concept in treatment of burn injury: controlled slow-release granulocyte-monocyte colony-stimulating factor chitosan gel system.
abstract: OBJECTIVE
  The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing.
  
  
  METHODS
  In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer.
  
  
  RESULTS
  The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed.
  
  
  CONCLUSIONS
  The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.
authors: Acibadem Health Group, Department of General Surgery, Atasehir Hospital, Istanbul, Turkey.
authors: Serife
authors: S
authors: Simsek
authors: Halil Ibrahim
authors: HI
authors: Canter
authors: Ersoy
authors: E
authors: Konas
authors: Petek
authors: P
authors: Korkusuz
authors: Devrim
authors: D
authors: Demir
authors: Filiz
authors: F
authors: Oner
authors: Ibrahim
authors: I
authors: Unsal
authors: Mehmet Emin
authors: ME
authors: Mavili
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy*; D048271:Chitosan / Q000008:administration & dosage* / Q000494:pharmacology*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000494:pharmacology*; D005782:Gels / Q000008:administration & dosage* / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D016179:Granulocyte Colony-Stimulating Factor; D048271:Chitosan