title: Millimeter wave radiation induces apoptosis via affecting the ratio             of Bax/Bcl-2 in SW1353 human chondrosarcoma cells.
abstract: The efficacy and safety of millimeter wave radiation has been proven for             various types of malignant tumors. However, the mechanisms underlying effects             of millimeter wave radiation on apoptosis are still unclear. The present study             was undertaken to examine the effects of millimeter wave radiation on cell apoptosis             and mitochondrial membrane potential, and to determine the molecular mechanism             of millimeter wave radiation-induced apoptosis by investigating the expression             of Bcl-2 family proteins (Bcl-2, Bax), caspase-9 and caspase-3 in SW1353 cells.             We found that millimeter wave radiation suppressed the viability of SW1353 cells,             demonstrating that millimeter wave radiation induced cell apoptosis and reduced             cell viability in a time-dependent manner. Furthermore, we observed that treatment             of cells with millimeter wave radiation significantly induced loss of mitochondrial             membrane potential, upregulated proapoptotic Bax, caspase-9 and caspase-3, but             did not significantly change levels of antiapoptotic Bcl-2. These data suggested             that millimeter wave radiation may induce apoptosis via affecting the ratio of             Bax/Bcl-2 in SW1353 cells.
authors: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, PR China.
authors: Xihai
authors: X
authors: Li
authors: Hongzhi
authors: H
authors: Ye
authors: Liangliang
authors: L
authors: Cai
authors: Fangrong
authors: F
authors: Yu
authors: Wenlie
authors: W
authors: Chen
authors: Ruhui
authors: R
authors: Lin
authors: Chunsong
authors: C
authors: Zheng
authors: Huifeng
authors: H
authors: Xu
authors: Jinxia
authors: J
authors: Ye
authors: Guangwen
authors: G
authors: Wu
authors: Xianxiang
authors: X
authors: Liu
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects*; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D061945:Caspase Inhibitors; D002470:Cell Survival / Q000528:radiation effects; D002813:Chondrosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D004789:Enzyme Activation / Q000528:radiation effects; D015870:Gene Expression / Q000528:radiation effects; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000528:radiation effects; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015854:Up-Regulation / Q000528:radiation effects
chemical_list: D061945:Caspase Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D053148:Caspase 3; D053453:Caspase 9