title: A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3).
abstract: Although most patients with peripheral T-cell lymphoma (PTCL) show clonal rearrangement of T-cell receptor genes, few PTCLs show recurrent chromosomal abnormalities. We describe here a rare chromosomal rearrangement, t(14;19)(q11.2;q13.3), in a Lennert's lymphoma, a variant of PTCL, not otherwise specified. Sequential fluorescence in situ hybridization assays showed that the breakpoint in 19q13.3 was located distal to the BCL3 and PVRL2 genes, both of which may be candidate proto-oncogenes. These findings suggest that another gene is involved in the pathogenic characteristics observed in this patient with Lennert's lymphoma.
authors: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
authors: S Y
authors: SY
authors: Shin
authors: S
authors: S
authors: Jang
authors: C-J
authors: CJ
authors: Park
authors: H-S
authors: HS
authors: Chi
authors: K H
authors: KH
authors: Lee
authors: J
authors: J
authors: Huh
authors: E-J
authors: EJ
authors: Seo
mesh_terms: D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged