title: Feed-control development for succinic acid production with Anaerobiospirillum succiniciproducens.
abstract: The aim of this work was the development of a feed-control for a succinic acid production fed-batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. Based on the metabolism of Anaerobiospirillum succiniciproducens, a theoretical correlation between base consumption and glucose feed was established and proved in cultivation trials. With the established fed-batch process, the succinic acid yield could be increased to 0.875 (g/g glucose) in comparison to batch processes (0.60) with similar glucose concentrations. Additionally, the results indicate that the osmolarity of the medium has a significant influence on succinic acid production.
authors: Fraunhofer Institute for Environmental, Safety, and Energy Technology UMSICHT, Business Unit Renewable Resources, Oberhausen, Germany. karlheinz.bretz@umsicht.fraunhofer.de
authors: Karlheinz
authors: K
authors: Bretz
authors: Stephan
authors: S
authors: Kabasci
mesh_terms: D044064:Anaerobiospirillum / Q000254:growth & development* / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D019802:Succinic Acid / Q000378:metabolism*
chemical_list: D003470:Culture Media; D019802:Succinic Acid; D005947:Glucose