title: New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties.
abstract: A new bis-naphtho-γ-pyrone isomer named isochaetochromin A(1) was isolated along with known isochaetochromins B(1) and B(2) from the culture broth of Penicillium sp. FKI-4942 by solvent extraction, silica gel column chromatography and HPLC. Among them, isochaetochromin B(1) showed the most potent inhibitory activity of triacylglycerol synthesis with an IC(50) value of 5.6 μM, followed by isochaetochromins B(2) (IC(50), 11 μM) and A(1) (33 μM).
authors: Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors: Narihiro
authors: N
authors: Ugaki
authors: Daisuke
authors: D
authors: Matsuda
authors: Hiroyuki
authors: H
authors: Yamazaki
authors: Kenichi
authors: K
authors: Nonaka
authors: Rokuro
authors: R
authors: Masuma
authors: Satoshi
authors: S
authors: Omura
authors: Hiroshi
authors: H
authors: Tomoda
mesh_terms: D000818:Animals; D001483:Base Sequence; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010407:Penicillium / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014280:Triglycerides / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D004791:Enzyme Inhibitors; D009284:Naphthols; D011753:Pyrones; D014280:Triglycerides; D051048:Diacylglycerol O-Acyltransferase