title: Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient.
abstract: Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up.
authors: Department of Hematology, Dokuz Eylul University, Izmir, Turkey. drakatgi@gmail.com
authors: Abdullah
authors: A
authors: Katgi
authors: Pinar
authors: P
authors: Ataca
authors: Selda
authors: S
authors: Kahraman
authors: Ozden
authors: O
authors: Pişkin
authors: Mehmet A
authors: MA
authors: Ozcan
authors: Fatih
authors: F
authors: Demirkan
authors: Güner H
authors: GH
authors: Ozsan
authors: Bülent
authors: B
authors: Undar
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000139:chemically induced*; D015942:Factor VIIa / Q000009:adverse effects* / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D020521:Stroke / Q000139:chemically induced*
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa