title: Role of biological therapies in the development of personalized medicine.
abstract: Development of personalized medicine involves integration of several biotechnologies. This editorial stresses the important role that biological therapies such as cell and gene therapies, recombinant proteins and vaccines play in personalization of treatment. Cell-based therapies, particularly vaccines made from the patient's own tumor cells, were the first therapeutic vaccines for cancer. Adoptive cell therapy is an immunotherapy based on ex vivo expansion of autologous T lymphocytes and subsequent administration to cancer patients. Stem cells as well as genetic modification of cells has been used for in vivo production of therapeutic substances best suited for individual patients. Besides cell therapy, RNAi has been used for personalized therapy of cancer. Monoclonal antibodies, designed to bind specifically to receptors in certain tumors, are also personalized medicines.
authors: K K
authors: KK
authors: Jain
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D001691:Biological Therapy / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D019295:Computational Biology / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007107:Immune System; D055432:Metabolomics / Q000379:methods; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D057285:Precision Medicine / Q000379:methods*; D034622:RNA Interference; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D000911:Antibodies, Monoclonal; D016376:Oligonucleotides, Antisense; D011994:Recombinant Proteins