title: Deep vein thrombosis prophylaxis increases perioperative surgical site infection in a prospective cohort of patients undergoing colorectal surgery.
abstract: We hypothesize that use of postoperative heparin deep vein thrombosis prophylaxis influences development of surgical site infection (SSI) after colorectal surgery. From July 2008 to June 2009, patients undergoing an abdominal operation by colorectal surgeons at a single university-affiliated  teaching hospital were prospectively followed and more than 80 variables collected. One hundred eighty-one patients were identified. Forty-five per cent (n = 82) received heparin prophylaxis and 55 per cent (n = 99) did not. SSI occurred in 23 per cent (n = 19) of patients receiving heparin  versus 9 per cent (n = 9) who did not (P = 0.02). Univariate analysis found SSI to be associated with heparin (P = 0.02) and increased operative time (P = 0.03). Multivariate analysis showed that SSI was associated only with heparin use (P = 0.04; OR, 2.6;  95% CI, 1.1 to 6.6).
authors: Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA.
authors: Scott S
authors: SS
authors: Short
authors: Yosef
authors: Y
authors: Nasseri
authors: Alexandra
authors: A
authors: Gangi
authors: Dror
authors: D
authors: Berel
authors: Phillip
authors: P
authors: Fleshner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D002140:California / Q000453:epidemiology; D002648:Child; D003108:Colonic Diseases / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012002:Rectal Diseases / Q000601:surgery*; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000209:etiology; D020246:Venous Thrombosis / Q000150:complications / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006493:Heparin