title: Repetitive transcranial magnetic stimulation-induced seizure of a patient with adolescent-onset depression: a case report and literature review.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been used as an investigative and therapeutic tool in neuropsychiatry and is advocated as a therapy for the treatment of psychiatric disorders, particularly adult depression. The therapeutic efficacy of current antidepressants  applied to children or adolescents is unsatisfactory; thus innovative treatments such as rTMS are in demand. Large-scale clinical studies are required to determine the safety of rTMS for this age group. The present case report describes a 15-year-old female with depression who had seizure  and hypomania during the first session of rTMS concomitant to sertraline 100 mg/day orally. The patient continued on this regimen of sertraline therapy but rTMS was not repeated. Subsequent electroencephalogram (EEG) examination detected no abnormalities and no long-term complications were  observed. We suggest that rTMS should be used cautiously to treat adolescents with depressive disorders, particularly when used concomitant to antidepressant treatment.
authors: Department of Mental Health, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors: S-H
authors: SH
authors: Hu
authors: S-S
authors: SS
authors: Wang
authors: M-M
authors: MM
authors: Zhang
authors: J-W
authors: JW
authors: Wang
authors: J-B
authors: JB
authors: Hu
authors: M-L
authors: ML
authors: Huang
authors: N
authors: N
authors: Wei
authors: W-H
authors: WH
authors: Zhou
authors: H-L
authors: HL
authors: Qi
authors: W-J
authors: WJ
authors: Xu
authors: Y
authors: Y
authors: Xu
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D012640:Seizures / Q000209:etiology*; D020280:Sertraline / Q000627:therapeutic use; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline