title: A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel.
abstract: A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti-cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri-nuclear localization.
authors: Organic Macromolecular Chemistry, Saarland University, Saarbrücken, Germany.
authors: Prajakta
authors: P
authors: Dandekar
authors: Ratnesh
authors: R
authors: Jain
authors: Thomas
authors: T
authors: Stauner
authors: Brigitta
authors: B
authors: Loretz
authors: Marcus
authors: M
authors: Koch
authors: Gerhard
authors: G
authors: Wenz
authors: Claus-Michael
authors: CM
authors: Lehr
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D000077143:Docetaxel; D004337:Drug Carriers / Q000138:chemical synthesis*; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis*; D013213:Starch / Q000031:analogs & derivatives*; D043823:Taxoids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D004655:Emulsions; D011108:Polymers; D043823:Taxoids; D000077143:Docetaxel; D013213:Starch