title: Synthesis of the C1-C20 and C15-C27 segments of aplyronine A.
abstract: The synthesis of C1-C20 and C15-C27 segments of Aplyronine A is described. Oxidative cleavage of cyclic vinyl sulfones has been used to prepare key fragments of Aplyronine A. Key precursors are united by Horner-Wadsworth-Emmons and Julia-Kociensky olefination for the respective elaboration of the C1-C20 and C15-C27 segments.
authors: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
authors: Wan Pyo
authors: WP
authors: Hong
authors: Mohammad N
authors: MN
authors: Noshi
authors: Ahmad
authors: A
authors: El-Awa
authors: Philip L
authors: PL
authors: Fuchs
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry
chemical_list: D000475:Alkenes; D018942:Macrolides; D013450:Sulfones; C104057:aplyronine A