title: Survival study and treatment strategy for second primary tumors in the oral cavity in patients with nasopharyngeal carcinoma after definitive radiation.
abstract: BACKGROUND
  The purpose of this study was to investigate the clinicopathologic characteristics and prognostic factors of second primary tumors (SPTs) in the oral cavity in patients with nasopharyngeal carcinoma (NPC) after definitive radiation, and to determine an optimal treatment strategy for these patients.
  
  
  METHODS
  This retrospective study enrolled consecutive patients who were admitted to the Sun Yat-Sen University Cancer Center between 1990 and 2005.
  
  
  RESULTS
  The key prognostic factors influencing the survival were age when NPC was diagnosed, TNM stage, and surgery treatment modality. Multivariate analysis revealed that the clinical TNM stage was an independent risk factor for patient survival.
  
  
  CONCLUSIONS
  Clinical TNM stage was an independent prognostic factor that influenced the treatment outcome. Our data indicate that the survival of patients with SPTs in the oral cavity can be improved by modifying treatment strategy, and that surgery is preferred when SPTs are diagnosed at an earlier stage.
authors: State Key Laboratory of Oncology in South China and Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.
authors: Ming
authors: M
authors: Song
authors: Shi-Min
authors: SM
authors: Zhuang
authors: Shu-Wei
authors: SW
authors: Chen
authors: Quan
authors: Q
authors: Zhang
authors: An-Kui
authors: AK
authors: Yang
authors: Li-Ping
authors: LP
authors: Wang
authors: Zhu-Ming
authors: ZM
authors: Guo
mesh_terms: D000328:Adult; D002277:Carcinoma; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth; D009062:Mouth Neoplasms / Q000401:mortality* / Q000532:radiotherapy; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000401:mortality* / Q000532:radiotherapy; D016609:Neoplasms, Second Primary / Q000401:mortality* / Q000532:radiotherapy; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome