title: [3,4-methylene-dioxy-pyrovalerone (MDPV) epidemic?].
abstract: Little is known about 3,4-methylene-dioxy-pyrovalerone (MDPV), a new designer drug that has become popular in Hungary in the last couple of months. At the same time, its consumption, as a consequence of its low street-price, rises so fast that the event can be considered an epidemic. This paper reviews the chemistry, biochemistry and metabolism of MDPV. Then, on the basis of a few international reports and the author's own clinical observations, it discusses MDPV intoxication and withdrawal. In the metabolism of MDPV, the most important catalyst is the CYP2C19 isoenzyme, but the CYP1A2 and the CYP2D6 isoenzymes also play a crucial role. The formed catechols are conjugated with either glucuronic acid or sulfate. It is important to note that MDPV is consumed either together or in a sequence with other illicit drugs of abuse. As far as it can be established, MDPV use increases the activity and vigilance, decreases appetite and claim to sleep, but it can also provoke cardiac sensations and disturbance of perception. In the course of coming down, withdrawal after MDPV use, bone and muscle pain, hypersomnia, disturbance of vision are experienced, but panic attack may also occur. The appearance of new designer drugs on the market draws attention to a need of paradigm changing in spiritual field. Unless it happens these negative trends likely will speed up.
authors: Elméleti Biológiai Kutatócsoport Budapest Józsefvárosi Egészségügyi Szolgálat VIII. Támasz Gondozó Budapest Korányi S. u. 3/A 1089. mpkalapos@freemail.hu
authors: Miklós Péter
authors: MP
authors: Kalapos
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D052117:Benzodioxoles / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D015198:Designer Drugs / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D013287:Illicit Drugs / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D011619:Psychotropic Drugs / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D011759:Pyrrolidines / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000523:psychology*; D000094982:Synthetic Cathinone
chemical_list: D052117:Benzodioxoles; D015198:Designer Drugs; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D011759:Pyrrolidines; D001189:Aryl Hydrocarbon Hydroxylases; C504573:CYP1A2 protein, human; C045793:CYP2C19 protein, human; D019388:Cytochrome P-450 CYP1A2; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; D000094982:Synthetic Cathinone