title: Cunninghamella bertholletiae pneumonia showing a reversed halo sign on chest computed tomography scan following cord blood transplantation.
abstract: This is the first reported case of a patient who developed fungal pneumonia caused by Cunninghamella bertholletiae (= C. elegans) following cord blood transplantation and who showed a reversed halo sign on a chest computed tomography scan (CT). In addition, the pathological findings related to the reversed halo sign are described in detail for the first time. The patient died due to respiratory failure and at autopsy, a consolidation corresponding to the reversed halo sign noted on CT was found histologically to be composed of a central infarct with some retained air spaces surrounded by a peripheral ring-like hemorrhagic band. Pulmonary vasculatures were occluded by thrombi containing numerous Zygomycetes hyphae within the central infarct and less frequently along the surrounding hemorrhagic band. A reversed halo sign may be an early marker to initiate preemptive therapy against Zygomycetes including C. bertholletiae.
authors: Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan.
authors: Muneyoshi
authors: M
authors: Kimura
authors: Hideki
authors: H
authors: Araoka
authors: Naoyuki
authors: N
authors: Uchida
authors: Hideaki
authors: H
authors: Ohno
authors: Yoshitsugu
authors: Y
authors: Miyazaki
authors: Takeshi
authors: T
authors: Fujii
authors: Aya
authors: A
authors: Nishida
authors: Koji
authors: K
authors: Izutsu
authors: Atsushi
authors: A
authors: Wake
authors: Shuichi
authors: S
authors: Taniguchi
authors: Akiko
authors: A
authors: Yoneyama
mesh_terms: D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D020093:Cunninghamella / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007238:Infarction / Q000175:diagnosis / Q000473:pathology; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D008853:Microscopy; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D011014:Pneumonia / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed