title: Non-human primate dendritic cells.
abstract: Non-human primates (NHP) are essential translational models for biomedical research. Dendritic cells (DC) are a group of antigen presenting cells (APC) that play pivotal roles in the immunobiology of health and disease and are attractive cells for adoptive immunotherapy to stimulate and suppress immunity. DC have been studied extensively in humans and mice but until recently, have not been well characterized in NHP. This review considers the available data about DC across a range of NHP species and summarizes the understanding of in vitro-propagated DC and in vivo-isolated DC, which is now established. It is clear that although NHP DC exist within the paradigm of human DC, there are important functional and phenotypic differences when compared with human DC subsets. These differences need to be taken into account when designing preclinical, translational studies of DC therapy using NHP models.
authors: Transplantation Immunology Laboratory and Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Adelaide, South Australia, Australia.
authors: Shilpanjali
authors: S
authors: Jesudason
authors: Michael G
authors: MG
authors: Collins
authors: Natasha M
authors: NM
authors: Rogers
authors: Svjetlana
authors: S
authors: Kireta
authors: P Toby H
authors: PT
authors: Coates
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000943:Antigens, Differentiation / Q000032:analysis; D002454:Cell Differentiation; D002469:Cell Separation; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D003713:Dendritic Cells / Q000145:classification / Q000187:drug effects / Q000276:immunology* / Q000637:transplantation; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology; D007108:Immune Tolerance; D016130:Immunophenotyping; D016219:Immunotherapy, Adoptive; D023421:Models, Animal; D011323:Primates / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D013045:Species Specificity
chemical_list: D000943:Antigens, Differentiation; D016298:Hematopoietic Cell Growth Factors