title: Chronic myeloid leukemia: current perspectives.
abstract: Chronic myeloid leukemia (CML), characterized by the t(9;22) and BCR/ABL1 fusion, is a disease model for studying the mechanisms of genetic abnormalities in leukemogenesis. The detection of the t(9;22), characterization of the BCR/ABL fusion, and the discovery of imatinib have elegantly reflected the success of our research efforts in CML. However, genomic instabilities that lead to the formation of the BCR/ ABL1 fusion are not fully understood. It is important to understand how various genes that are involved in regulating the signaling pathway and epigenetic deregulation cooperate with the BCR/ABL1 fusion in the initiation and progression of CML.
authors: Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry Building 7-729, Chicago, IL 60611, USA. yanming-zhang@northwestern.edu
authors: Yanming
authors: Y
authors: Zhang
authors: Janet D
authors: JD
authors: Rowley
mesh_terms: D020732:Cytogenetic Analysis; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D010677:Philadelphia Chromosome