title: Immunological alterations used to predict infections in response to strenuous physical training.
abstract: The aim of this study was to screen leukocyte cell surface markers to identify possible predictors for infection related to physical training. Ten healthy soldiers (mean age, 19.1; mean body mass, 77.4 kg; mean VO2 peak, 4.54 L min(-1)/58.6 mL min(-1) kg(-1)) were included. Blood samples were collected and number of infections recorded before and after a 6-day training course. White blood cell distributions and expression of surface receptors changed during training. Before training, expression of CD3 on CD8+ lymphocytes and percent CD8+CD3 lymphocytes was lower, whereas CD4/CD8 ratio was higher among subjects who failed compared to those who completed the training. A subclinical infection before the start of the military training may alter the CD4/CD8 ratio. Prediction of future infections may be possible from pre-exercise immunological status, findings useful in military settings and exercise, where sudden infections may result in severe consequences.
authors: Astrand Laboratory of Work Physiology, The Swedish School of Sports and Health Sciences, PO Box 5626, SE-114 86 Stockholm, Sweden.
authors: Orjan
authors: O
authors: Ekblom
authors: Björn
authors: B
authors: Ekblom
authors: Christer
authors: C
authors: Malm
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000097:blood; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D008297:Male; D008889:Military Personnel; D010806:Physical Education and Training; D005082:Physical Exertion / Q000276:immunology*; D010865:Pilot Projects; D013548:Sweden; D055815:Young Adult
chemical_list: D017252:CD3 Complex