title: Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study.
abstract: OBJECTIVE
  It is not established whether myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is associated with structural brain changes. The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS.
  
  
  METHODS
  High-resolution structural 3 T cerebral MRI scanning was carried out in 26 patients with CFS and 26 age- and gender-matched healthy volunteers. Voxel-wise generalised linear modelling was applied to the processed MR data using permutation-based non-parametric testing, forming clusters at t>2.3 and testing clusters for significance at p<0.05, corrected for multiple comparisons across space.
  
  
  RESULTS
  Significant voxels (p<0.05, corrected for multiple comparisons) depicting reduced grey matter volume in the CFS group were noted in the occipital lobes (right and left occipital poles; left lateral occipital cortex, superior division; and left supracalcrine cortex), the right angular gyrus and the posterior division of the left parahippocampal gyrus. Significant voxels (p<0.05, corrected for multiple comparisons) depicting reduced white matter volume in the CFS group were also noted in the left occipital lobe.
  
  
  CONCLUSIONS
  These data support the hypothesis that significant neuroanatomical changes occur in CFS, and are consistent with the complaint of impaired memory that is common in this illness; they also suggest that subtle abnormalities in visual processing, and discrepancies between intended actions and consequent movements, may occur in CFS.
authors: Department of Imaging, Hammersmith Hospital, London, UK. basant.puri@imperial.ac.uk
authors: B K
authors: BK
authors: Puri
authors: P M
authors: PM
authors: Jakeman
authors: M
authors: M
authors: Agour
authors: K D R
authors: KD
authors: Gunatilake
authors: K A C
authors: KA
authors: Fernando
authors: A I
authors: AI
authors: Gurusinghe
authors: I H
authors: IH
authors: Treasaden
authors: A D
authors: AD
authors: Waldman
authors: P
authors: P
authors: Gishen
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology*; D009929:Organ Size; D012016:Reference Values; D012680:Sensitivity and Specificity