title: Structural perspective on the direct inhibition mechanism of EGCG on mammalian histidine decarboxylase and DOPA decarboxylase.
abstract: Histidine decarboxylase (HDC) and l-aromatic amino acid decarboxylase (DDC) are homologous enzymes that are responsible for the synthesis of important neuroactive amines related to inflammatory, neurodegenerative, and neoplastic diseases. Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, has been shown to target histamine-producing cells and to promote anti-inflammatory, antitumor, and antiangiogenic effects. Previous experimental work has demonstrated that EGCG has a direct inhibitory effect on both HDC and DDC. In this study, we investigated the binding modes of EGCG to HDC and DDC as a first step for designing new polyphenol-based HDC/DDC-specific inhibitors.
authors: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.
authors: M Victoria
authors: MV
authors: Ruiz-Pérez
authors: Almudena
authors: A
authors: Pino-Ángeles
authors: Miguel A
authors: MA
authors: Medina
authors: Francisca
authors: F
authors: Sánchez-Jiménez
authors: Aurelio A
authors: AA
authors: Moya-García
mesh_terms: D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004296:Dopa Decarboxylase / Q000737:chemistry*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors / Q000737:chemistry*; D008322:Mammals; D056004:Molecular Dynamics Simulation; D013662:Tea / Q000737:chemistry
chemical_list: D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D004296:Dopa Decarboxylase; D006640:Histidine Decarboxylase