title: From systems biology to systems biomedicine.
abstract: Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to furthermore translate mechanistic insights in biological systems to clinical application, with the central aim of improving patients' quality of life. The challenge is to find theoretically well-chosen models for the contextually correct and intelligible representation of multi-scale biological systems. In this review, we discuss the current state of Systems Biology, highlight the emergence of Systems Biomedicine, and highlight some of the topics and views that we think are important for the efficient application of Systems Theory in Biomedicine.
authors: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg. paul.antony@uni.lu
authors: Paul M A
authors: PM
authors: Antony
authors: Rudi
authors: R
authors: Balling
authors: Nikos
authors: N
authors: Vlassis
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D006801:Humans; D008519:Medicine, Traditional; D008954:Models, Biological; D011788:Quality of Life; D049490:Systems Biology; D013812:Therapeutics