title: Magnitude and variability of the glucagon-like peptide-1 response in patients with type 2 diabetes up to 2 years following gastric bypass surgery.
abstract: OBJECTIVE
  To characterize the magnitude and variance of the change of glucose and glucagon-like peptide-1 (GLP-1) concentrations, and to identify determinants of glucose control up to 2 years after gastric bypass (GBP).
  
  
  METHODS
  Glucose and GLP-1 concentrations were measured during an oral glucose challenge before and 1, 12, and 24 months after GBP in 15 severely obese patients with type 2 diabetes.
  
  
  RESULTS
  Glucose area under the curve from 0 to 180 min (AUC(0-180)) started decreasing in magnitude (P < 0.05) 1 month after surgery. GLP-1 AUC(0-180) increased in magnitude 1 month after GBP (P < 0.05), with increased variance only after 1 year (P(σ)(2) ≤ 0.001). GLP-1 AUC(0-180) was positively associated with insulin AUC(0-180) (P = 0.025).
  
  
  CONCLUSIONS
  The increase in variance of GLP-1 at 1 and 2 years after GBP suggests mechanisms other than proximal gut bypass to explain the enhancement of GLP-1 secretion. The association between GLP-1 and insulin concentrations supports the idea that the incretins are involved in glucose control after GBP.
authors: New York Obesity Nutrition Research Center, St. Luke’s Roosevelt Hospital Center, New York, NewYork, USA.
authors: Bart J
authors: BJ
authors: Van der Schueren
authors: Peter
authors: P
authors: Homel
authors: Mariam
authors: M
authors: Alam
authors: Keesandra
authors: K
authors: Agenor
authors: Gary
authors: G
authors: Wang
authors: David
authors: D
authors: Reilly
authors: Blandine
authors: B
authors: Laferrère
mesh_terms: D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D054795:Incretins; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology* / Q000601:surgery*
chemical_list: D001786:Blood Glucose; D054795:Incretins; D052216:Glucagon-Like Peptide 1