title: Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis.
abstract: The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P < 0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.
authors: Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors: Koichi
authors: K
authors: Tsuneyama
authors: Yen-Chen
authors: YC
authors: Chen
authors: Makoto
authors: M
authors: Fujimoto
authors: Yoshiyuki
authors: Y
authors: Sasaki
authors: Wataru
authors: W
authors: Suzuki
authors: Tsutomu
authors: T
authors: Shimada
authors: Seiichi
authors: S
authors: Iizuka
authors: Mitsunobu
authors: M
authors: Nagata
authors: Masaki
authors: M
authors: Aburada
authors: Shao-Yuan
authors: SY
authors: Chen
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000150:complications / Q000628:therapy*; D006931:Hyperbaric Oxygenation; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000628:therapy*; D007150:Immunohistochemistry; D050152:Intra-Abdominal Fat / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D009765:Obesity / Q000150:complications / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha