title: Atypical necrotizing encephalitis associated with systemic canine distemper virus infection in pups.
abstract: This report describes the naturally occurring atypical neuropathological manifestation of systemic canine distemper virus (CDV) infection in two 16-day-old Pit Bull pups. CDV-induced changes affected the gray and white matter of the forebrain while sparing the hindbrain. Histologically, there was necrosis with destruction of the nervous parenchyma due to an influx of inflammatory and reactive cells associated with eosinophilic intranuclear inclusion bodies within glial cells. Positive immunoreactivity against CDV antigens was predominantly observed within astrocytes and neurons. RT-PCR was used to amplify CDV-specific amplicons from brain fragments. These findings suggest the participation of CDV in the etiopathogenesis of these lesions.
authors: Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, P.O. Box 6001, 86051-990 Paraná, Brazil.
authors: Alexandre Mendes
authors: AM
authors: Amude
authors: Selwyn Arlington
authors: SA
authors: Headley
authors: Amauri Alcindo
authors: AA
authors: Alfieri
authors: Suely Nunes Esteves
authors: SN
authors: Beloni
authors: Alice Fernandes
authors: AF
authors: Alfieri
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D002490:Central Nervous System / Q000473:pathology / Q000821:virology; D004216:Distemper / Q000821:virology*; D004217:Distemper Virus, Canine; D004285:Dogs; D004660:Encephalitis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D009336:Necrosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology
chemical_list: D000956:Antigens, Viral