title: Dysidavarones A-D, new sesquiterpene quinones from the marine sponge Dysidea avara.
abstract: Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated.
authors: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
authors: Wei-Hua
authors: WH
authors: Jiao
authors: Xiao-Jun
authors: XJ
authors: Huang
authors: Ji-Si
authors: JS
authors: Yang
authors: Fan
authors: F
authors: Yang
authors: Shu-Jian
authors: SJ
authors: Piao
authors: Hao
authors: H
authors: Gao
authors: Jia
authors: J
authors: Li
authors: Wen-Cai
authors: WC
authors: Ye
authors: Xin-Sheng
authors: XS
authors: Yao
authors: Wan-Sheng
authors: WS
authors: Chen
authors: Hou-Wen
authors: HW
authors: Lin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D047088:Dysidea / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D011809:Quinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D011809:Quinones; D012717:Sesquiterpenes; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1