title: C-type natriuretic peptide forms in adult hyperthyroidism: correlation with thyroid hormones and markers of bone turnover.
abstract: BACKGROUND
  Plasma C-type natriuretic peptide (CNP) forms correlate with linear growth velocity in juveniles. In hyperthyroid children, plasma CNP products fall in parallel with height velocity and thyroid hormones (TH) as euthyroidism is restored. The effect of TH on CNP forms after completion of endochondral growth is unknown.
  
  
  OBJECTIVE
  To determine the effect of restoring euthyroidism on plasma CNP forms and bone turnover markers (BTMs) in hyperthyroid adults.
  
  
  METHODS
  We performed a prospective observational study in 20 adults (19 women) with acquired hyperthyroidism before and during carbimazole treatment. INTERVENTION AND MAIN OUTCOMES: Blood levels of CNP, amino-terminal propeptide of CNP (NTproCNP), TH and BTMs - bone-specific alkaline phosphatase, osteocalcin, procollagen type 1 amino-terminal propeptide and type 1 collagen C-telopeptide (CTx) - were measured before and during the first 6 months of carbimazole treatment and correlations determined.
  
  
  RESULTS
  Both CNP and NTproCNP were significantly correlated with TH at baseline. As in children, decreases in CNP forms were closely associated with fall in TH. Significant associations were found between CNP forms and CTx.
  
  
  CONCLUSIONS
  CNP production from tissues other than endochondral cartilage is responsive to TH. Strong temporal links with markers of bone resorption suggest that CNP may also participate in bone remodelling in the adult skeleton.
authors: Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand.
authors: Belinda J
authors: BJ
authors: Schouten
authors: Timothy C
authors: TC
authors: Prickett
authors: Penelope J
authors: PJ
authors: Hunt
authors: A Mark
authors: AM
authors: Richards
authors: Mitchell E
authors: ME
authors: Geffner
authors: Robert C
authors: RC
authors: Olney
authors: Eric A
authors: EA
authors: Espiner
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002231:Carbimazole / Q000627:therapeutic use; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D015675:Osteocalcin / Q000097:blood; D011446:Prospective Studies; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D013963:Thyroid Hormones; D015675:Osteocalcin; D020098:Natriuretic Peptide, C-Type; D002231:Carbimazole; D000469:Alkaline Phosphatase