title: A review of neurobiological vulnerability factors and treatment implications for comorbid tobacco dependence in schizophrenia.
abstract: There is converging evidence that certain subpopulations of smokers, such as smokers with a serious mental illness like schizophrenia (SCZ), are more likely to become addicted to tobacco and are less likely to quit smoking. This review focuses on the unique risk factors that may increase vulnerability to the initiation and maintenance of nicotine addiction in persons with schizophrenia and other psychotic disorders and also reviews the latest approaches to treating nicotine addiction and schizophrenia based on our neurobiological understanding of central nicotinic receptor systems and related neurotransmitters. In addition, suggestions for future lines of research to better understand reasons for the comorbidity of nicotine addiction in schizophrenia are discussed.
authors: Addiction Psychiatry Program, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors: Victoria C
authors: VC
authors: Wing
authors: Caroline E
authors: CE
authors: Wass
authors: Debra W
authors: DW
authors: Soh
authors: Tony P
authors: TP
authors: George
mesh_terms: D000818:Animals; D015897:Comorbidity; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009538:Nicotine / Q000633:toxicity; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D011978:Receptors, Nicotinic / Q000737:chemistry / Q000378:metabolism; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D012565:Schizophrenic Psychology; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000378:metabolism / Q000523:psychology* / Q000628:therapy*
chemical_list: D011978:Receptors, Nicotinic; D009538:Nicotine