title: Roles of IL-8 in ocular inflammations: a review.
abstract: BACKGROUND
  This review presents the current in vitro and in vivo animal and human research on the roles of IL-8 in ocular inflammatory diseases.
  
  
  METHODS
  Data sources were a literature review using Pub Med, Medline, and ISI databases (from 1990 to 2011). Search items included interleukine-8 (IL-8), CXCL8, chemokines, cytokines, alone or in combination with the, serum, aqueous, vitreous, eye, ocular, ocular tissues, ophthalmic, and review.
  
  
  RESULTS
  IL-8 may be involved in primary or secondary ocular inflammations. Ocular effects of IL-8 differ based on the source of the secretion and site of the action. The most important effects of IL-8 in the eyes are angiogenic activities and induction of ocular inflammation.
  
  
  CONCLUSIONS
  IL-8 plays important roles in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-8 targeted immunotherapy has been introduced as an important treatment modality, provided that IL-8 signal blocking takes place in desired areas and tissues.
authors: Immunoregulation Research Center, Shahed University, Tehran, Iran. ghasemi518@yahoo.com
authors: Hassan
authors: H
authors: Ghasemi
authors: Tooba
authors: T
authors: Ghazanfari
authors: Roya
authors: R
authors: Yaraee
authors: Soghrat
authors: S
authors: Faghihzadeh
authors: Zuhair Mohammad
authors: ZM
authors: Hassan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015817:Eye Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D016209:Interleukin-8 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D011487:Protein Conformation; D051381:Rats; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016209:Interleukin-8