title: T-bet employs diverse regulatory mechanisms to repress transcription.
abstract: Lineage-defining transcription factors are responsible for activating the signature genes required for a given cell fate. They are also needed to repress the genetic programs associated with alternative lineage decisions. The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation. Numerous studies have explored the mechanisms by which T-bet activates the Th1 gene profile, but until recently not much was known about the mechanisms that T-bet utilizes to negatively regulate alternative T helper cell differentiation pathways such as the Th2 and Th17 fates. Here, we discuss new advances in the field that highlight the diverse mechanisms that T-bet employs to antagonize the gene programs for alternative T helper cell fates.
authors: Department of Immunology, University of Washington, Seattle, WA 98195, USA.
authors: Kenneth J
authors: KJ
authors: Oestreich
authors: Amy S
authors: AS
authors: Weinmann
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D020825:T-Box Domain Proteins / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell; D020825:T-Box Domain Proteins