title: Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice.
abstract: In this study, 10 already described secondary metabolites and 2 unknown metabolites were identified in an extract of Monascus purpureus by high-performance liquid chromatography-diode array detection. The unknown metabolites were isolated and their chemical structures were elucidated. The new metabolites possess the molecular formulas C(21)H(27)NO(4) and C(23)H(31)NO(4). They were named monascopyridines E and F due to their pyridine backbone. The cytotoxicity of the new compounds was studied using immortalised human kidney epithelial cells displaying IC(50) values in the micromolar range.
authors: Institute of Food Chemistry, Westfälische Wilhelms-Universität, Corrensstrasse 45, D-48149 Münster, Germany.
authors: Ines
authors: I
authors: Ferse
authors: Marina
authors: M
authors: Langlitz
authors: Karin
authors: K
authors: Kleigrewe
authors: Sebastian
authors: S
authors: Rzeppa
authors: Marlies
authors: M
authors: Lenczyk
authors: Henning
authors: H
authors: Harrer
authors: Benedikt
authors: B
authors: Cramer
authors: Hans-Ulrich
authors: HU
authors: Humpf
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D032741:Monascus / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011725:Pyridines