title: Assessment of glomerular filtration rate with dynamic computed tomography in normal Beagle dogs.
abstract: The objective of our study was to determine individual and global glomerular filtration rates (GFRs) using dynamic renal computed tomography (CT) in Beagle dogs. Twenty-four healthy Beagle dogs were included in the experiment. Anesthesia was induced in all dogs by using propofol and isoflurane prior to CT examination. A single slice of the kidney was sequentially scanned after a bolus intravenous injection of contrast material (iohexol, 1 mL/kg, 300 mgI/mL). Time attenuation curves were created and contrast clearance per unit volume was calculated using a Patlak plot analysis. The CT-GFR was then determined based on the conversion of contrast clearance per unit volume to contrast clearance per body weight. At the renal hilum, CT-GFR values per unit renal volume (mL/min/mL) of the right and left kidneys were 0.69 ± 0.04 and 0.57 ± 0.05, respectively. No significant differences were found between the weight-adjusted CT-GFRs in either kidney at the same renal hilum (p = 0.747). The average global GFR was 4.21 ± 0.25 mL/min/kg and the whole kidney GFR was 33.43 ± 9.20 mL/min. CT-GFR techniques could be a practical way to separately measure GFR in each kidney for clinical and research purposes.
authors: Department of Medical Imaging, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea.
authors: Jinhwa
authors: J
authors: Chang
authors: Sujin
authors: S
authors: Kim
authors: Joohyun
authors: J
authors: Jung
authors: Heechun
authors: H
authors: Lee
authors: Hojung
authors: H
authors: Choi
authors: Dongwoo
authors: D
authors: Chang
authors: Youngwon
authors: Y
authors: Lee
authors: Junghee
authors: J
authors: Yoon
authors: Mincheol
authors: M
authors: Choi
mesh_terms: D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D008297:Male; D012016:Reference Values; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*