title: The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation.
abstract: A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-carboxyanhydride ring opening polymerisation is disclosed. Poly-L-glutamic acid and poly-L-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly-L-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing polymers that are commonly employed in contemporary medical devices.
authors: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. paul.d.thornton@dcu.ie
authors: Paul D
authors: PD
authors: Thornton
authors: Ruairi
authors: R
authors: Brannigan
authors: Joanna
authors: J
authors: Podporska
authors: Brid
authors: B
authors: Quilty
authors: Andreas
authors: A
authors: Heise
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013818:Thermogravimetry
chemical_list: D000812:Anhydrides; D000900:Anti-Bacterial Agents; D010455:Peptides; D011108:Polymers; D012833:Siloxanes