title: A practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines.
abstract: Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of an unsaturated δ-keto ester derivative with (R)-phenylglycinol and the stereoselective hydrogenation of the resulting tricyclic oxazoloquinolone lactams.
authors: Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028-Barcelona, Spain. amat@ub.edu
authors: Mercedes
authors: M
authors: Amat
authors: Laura
authors: L
authors: Navío
authors: Núria
authors: N
authors: Llor
authors: Elies
authors: E
authors: Molins
authors: Joan
authors: J
authors: Bosch
mesh_terms: D006865:Hydrogenation; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D011804:Quinolines; C037920:decahydroquinoline-5-carboxylic acid