title: [Effects of Kit gene on coat depigmentation in white horses].
abstract: Coat color of horse is an important basis for both species identification and individual recognition and is also one of the important references traits for breeding.  Therefore, the research on the mechanism of coat fading has become an important part of horses' coat color study. It has been found that the white phenotype is closely related to the mutation of kit gene, which is located on chromosome 3. Investigated results showed that the formation of the epidermal melanoblast and melanin  relies on the expression of kit gene, which determines the presence of white phenotype. Nevertheless, studies results have shown that the mutation of kit gene in the white horse exhibited significant differences among species. Horses that the coat color completely faded are very rare and are found occasionally in a few species. However, a larger number of horses that coat color completely faded, called Mongolian white horse, are found in West Ujimqin , Xilin Gol League, Inner Mongolia. Therefore, genetic mechanism of color fading in Mongolian white horses is still not clear. No typical mutations have been observed in 21 exons of kit gene in Mongolian white horse. This paper summarized recent international studies on molecular mechanism of color fading and tried to lay the foundation for the study of formation mechanism of Mongolian white horse. The aim of this review is to provide some valuable references to horses coat color research and breeding.
authors: Inner Mongolia Agricultural University, Hohhot, China. baidongyi1983@163.com
authors: Dong-Yi
authors: DY
authors: Bai
authors: Li-Hua
authors: LH
authors: Yang
authors: Unerhu
authors: U
authors: Unerhu
authors: Yi-Ping
authors: YP
authors: Zhao
authors: Qi-Nan
authors: QN
authors: Zhao
authors: Hasigaowa
authors: H
authors: Hasigaowa
authors: Manglai
authors: M
authors: Dugarjaviin
mesh_terms: D000818:Animals; D006200:Hair Color; D006734:Horse Diseases / Q000235:genetics* / Q000378:metabolism; D006736:Horses / Q000235:genetics / Q000378:metabolism; D017496:Hypopigmentation / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D009154:Mutation; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics* / Q000378:metabolism
chemical_list: D019009:Proto-Oncogene Proteins c-kit