title: Relation between eardrum flap area and healing outcome of traumatic eardrum perforation.
abstract: OBJECTIVE
  To retrospectively study the clinical effects of eardrum flap area on the healing outcome following traumatic perforation.
  
  
  METHODS
  Totally 291 traumatic eardrum perforations with in-/everted edges were included in this study. They were randomly divided into three groups and received conservative treatment, epidermal growth factor (EGF) via Gelfoam patching, or edge-approximation plus Gelfoam patching respectively. Patients in each group were further divided into two subgroups according to the eardrum flap area less than or equal to 1/2 or >1/2 of the perforation size. The healing rate and mean closure time after tympanic membrane perforation were evaluated at three months.
  
  
  RESULTS
  Of the total 291 participants, 281 were included in the final statistical analysis. The area of curled edge did not affect the healing outcome significantly in any groups (P>0.05). The healing rate varied slightly: 90.7% vs 92.3% in spontaneous healing group, 98.2% vs 97.4% in  EGF via Gelfoam patching group, and 96.5% vs 100% in  edge-approximation plus Gelfoam patching group. In addition, in all groups the area of curled edge did not affect the mean closure time significantly (P>0.05). The closure time was (32.3+/-2.4) d vs (30.6+/-3.1) d in sponaneous healing group, (13.4+/-2.5) d vs (13.1+/-1.9) d in EGF via Gelfoam patching group, and (11.9+/-3.1) d vs (12.2+/-2.1) d in edge-approximation plus Gelfoam patching group.
  
  
  CONCLUSIONS
  The eardrum flap area of traumatic eardrum perforation does not significantly affect the clinical outcomes.
authors: Department of Otorhinolaryngology, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China.
authors: Zheng-Cai
authors: ZC
authors: Lou
authors: Yong-Mei
authors: YM
authors: Tang
authors: Xiao-Hong
authors: XH
authors: Wu
authors: Jia-Hai
authors: JH
authors: Chen
mesh_terms: D005781:Gelatin Sponge, Absorbable; D006801:Humans; D012189:Retrospective Studies; D014432:Tympanic Membrane; D018058:Tympanic Membrane Perforation; D014945:Wound Healing