title: Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme.
abstract: The direct three-component aza-Diels-Alder reaction of aromatic aldehyde, aromatic amine, and 2-cyclohexen-1-one was catalyzed by hen egg white lysozyme for the first time. Under the optimized conditions investigated in this paper, the enzyme-catalyzed aza-Diels-Alder reaction gave yields up to 98% and stereoselectivity of endo/exo ratios up to 90:10.
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors: Yan-Hong
authors: YH
authors: He
authors: Wen
authors: W
authors: Hu
authors: Zhi
authors: Z
authors: Guan
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003512:Cyclohexanones / Q000737:chemistry*; D004529:Egg White / Q000737:chemistry*; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001372:Aza Compounds; D003512:Cyclohexanones; C028215:2-cyclohexen-1-one; C421864:hen egg lysozyme; D009113:Muramidase