title: [Does paracetamol improve recovery after stroke?].
abstract: An increase in body temperature in the first days following stroke is related to poor functional outcome. High-dose paracetamol (acetaminophen) reduces the body temperature by 0.3°C and can prevent fever. Paracetamol treatment is simple, cheap and has few side effects. In the first "Paracetamol (Acetaminophen) in Stroke" (PAIS) study, there was a beneficial effect of high-dose paracetamol on functional outcome in patients with stroke and a body temperature of 37.0°C or above. Because this result was found in a subgroup analysis, a new study is needed to confirm this finding. Recently the randomised PAIS 2 study was initiated. This study aims to assess the effect of high-dose paracetamol on functional outcome in patients with acute stoke and a body temperature of 37.0°C or above.
authors: Erasmus Medisch Centrum, afd. Neurologie, Rotterdam, the Netherlands. i.deridder@erasmusmc.nl
authors: Inter R
authors: IR
authors: de Ridder
authors: H Bart
authors: HB
authors: van der Worp
authors: H Maarten A
authors: HM
authors: van Gemert
authors: A H C M L Tobien
authors: AH
authors: Schreuder
authors: Annemieke
authors: A
authors: Ruitenberg
authors: E Lisette
authors: EL
authors: Maasland
authors: Ritu
authors: R
authors: Saxena
authors: Diederik W J
authors: DW
authors: Dippel
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000517:prevention & control; D006801:Humans; D007036:Hypothermia, Induced; D020521:Stroke / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen