title: Prevalence of Bordetella hinzii in mice in experimental facilities in Japan.
abstract: To reveal the current status of the prevalence of Bordetella hinzii in mice in experimental facilities in Japan, a survey of this agent was performed by culture of tracheal swabs from a total of 12,923 mice from 1699 facilities (12,192 mice from 1572 facilities in universities and research institutes and 731 mice from 127 facilities in pharmaceutical companies) in total. In the results, 195 out of 12,192 mice (1.6%) from 44 out of 1572 facilities (2.8%) in universities and research institutes were positive for B. hinzii. No B. hinzii-positive mice were found in 127 pharmaceutical companies surveyed. Gross lesions in the lungs with isolation of B. hinzii were observed in seven mice from four universities, and the lesions were identified as bronchopneumonia histopathologically. To our knowledge, this is the first report to reveal the prevalence of B. hinzii in laboratory mice.
authors: Central Institute for Experimental Animals, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216-0001, Japan. nobuh@ciea.or.jp
authors: Nobuhito
authors: N
authors: Hayashimoto
authors: Hanako
authors: H
authors: Morita
authors: Masahiko
authors: M
authors: Yasuda
authors: Tomoko
authors: T
authors: Ishida
authors: Shuko
authors: S
authors: Kameda
authors: Akira
authors: A
authors: Takakura
authors: Toshio
authors: T
authors: Itoh
mesh_terms: D000818:Animals; D001884:Bordetella / Q000145:classification* / Q000302:isolation & purification*; D001885:Bordetella Infections / Q000453:epidemiology / Q000662:veterinary*; D004345:Drug Industry; D007564:Japan / Q000453:epidemiology; D007753:Laboratories; D007756:Laboratory Animal Science; D051379:Mice; D015995:Prevalence; D012376:Rodent Diseases / Q000453:epidemiology / Q000382:microbiology*