title: Tachyphylaxis/ tolerance to antidepressive medications: a review.
abstract: Tachyphylaxis is the appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance; the symptoms could appear also during treatment with antidepressants. Although the real frequency of the phenomenon is unclear, it may be as high as 33% during the pharmacological treatment of depression. The review deals with the possible causes and the treatment of the tachyphylaxis following antidepressant treatment.
authors: The Jerusalem Mental Health Center, Kfar Shaul Hospital, Jerusalem, Israel. ngkatz@012.net.il
authors: Gregory
authors: G
authors: Katz
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D013618:Tachyphylaxis
chemical_list: D000928:Antidepressive Agents