title: Altered expression of NFY-C and RORA in colorectal adenocarcinomas.
abstract: NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.
authors: Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, Medical School, University of Patras, Greece. agathonisiotisa@yahoo.gr
authors: Anastasia E
authors: AE
authors: Kottorou
authors: Anna G
authors: AG
authors: Antonacopoulou
authors: Fotinos-Ioannis D
authors: FI
authors: Dimitrakopoulos
authors: Athanasios C
authors: AC
authors: Tsamandas
authors: Chrisoula D
authors: CD
authors: Scopa
authors: Theodore
authors: T
authors: Petsas
authors: Haralabos P
authors: HP
authors: Kalofonos
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D023081:CCAAT-Binding Factor / Q000032:analysis / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000032:analysis / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D023081:CCAAT-Binding Factor; C469358:NFYC protein, human; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D012333:RNA, Messenger; C539738:RORA protein, human