title: A case of concurrent sarcoidosis, aortitis syndrome and Crohn's disease.
abstract: A 24-year-old man was referred to our hospital due to bilateral hilar lymphadenopathy on chest radiography. He had been under medication for aortitis syndrome and Crohn's disease for 12 years. Surgical biopsy from the anterior segment of the left upper lobe and mediastinal lymph nodes was performed under video-assisted thoracoscopy. Histopathological examination revealed epithelioid cell granulomas without caseous necrosis, compatible with sarcoidosis. Full sequence analysis of the CARD15 gene, which is reportedly related to the formation of granulomatous lesions in Crohn's disease and sarcoidosis revealed no mutation of CARD15 gene. This is the first report of concurrent sarcoidosis, Crohn's disease and aortitis syndrome in an individual.
authors: Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan. koizumik@nagasaki-u.ac.jp
authors: Koichi
authors: K
authors: Izumikawa
authors: Noriko
authors: N
authors: Motoi
authors: Hisashi
authors: H
authors: Takaya
authors: Atsushi
authors: A
authors: Miyamoto
authors: Yoshinobu
authors: Y
authors: Eishi
authors: Kunihiko
authors: K
authors: Yoshimura
authors: Kazuma
authors: K
authors: Kishi
mesh_terms: D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis*; D004252:DNA Mutational Analysis; D006801:Humans; D008297:Male; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis*; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein