title: Effect of glycine on the cyclooxygenase pathway of the kidney arachidonic acid metabolism in a rat model of metabolic syndrome.
abstract: The kidneys are organs that can be severely impaired by metabolic syndrome (MS). This is characterized by the association of various pathologies such as hypertension, dyslipidemia, and type-2 diabetes. Glycine, a nonessential amino acid, is known to possess various protective effects in the kidney, such as a decrease in the deterioration of renal function and a reduction of the damage caused by hypoxia. In a rat model of MS, the effect of glycine on the cyclooxygenase (COX) pathway of arachidonic acid (AA) metabolism was studied in isolated perfused kidney. MS was induced in Wistar rats by feeding them a 30% sucrose solution for 16 weeks. The addition of 1% glycine to their drinking water containing 30% sucrose, for 8 weeks, reduced high blood pressure, triglyceride levels, insulin concentration, homeostatis model assessment (HOMA) index, albuminuria, AA concentration in kidney homogenate, renal perfusion pressure, prostaglandin levels, PLA2 expression, and COX isoform expression, compared with MS rats that did not receive the glycine supplement. Glycine receptor expression decreased significantly with MS, but glycine treatment increased it. The results suggest that in the MS model, 1% glycine treatment protects the kidney from damage provoked by the high sucrose consumption, by acting as an anti-inflammatory on the COX pathway of AA metabolism in kidney.
authors: a Departments of Pathology, Cardiovascular Biomedicine, Biochemistry and Electromechanical Instrumentation, Instituto Nacional de Cardiología "Ignacio Chávez," Juan Badiano 1, Sección XVI, Tlalpan, 14080 México DF, Mexico.
authors: Israel
authors: I
authors: Pérez-Torres
authors: Blanca
authors: B
authors: Ibarra
authors: Elizabeth
authors: E
authors: Soria-Castro
authors: Rocío
authors: R
authors: Torrico-Lavayen
authors: Natalia
authors: N
authors: Pavón
authors: Eulises
authors: E
authors: Diaz-Diaz
authors: Pedro L
authors: PL
authors: Flores
authors: Oscar
authors: O
authors: Infante
authors: Guadalupe
authors: G
authors: Baños
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D005998:Glycine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D017208:Rats, Wistar; D015398:Signal Transduction
chemical_list: D000893:Anti-Inflammatory Agents; D016718:Arachidonic Acid; D011451:Prostaglandin-Endoperoxide Synthases; D005998:Glycine