title: Linkage and association scan for tanning ability in an isolated Mongolian population.
abstract: Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultative and constitutive skin color, respectively. In our study population consisting of isolated Mongolian subjects, with common histories of environmental UV exposure during their nomadic life, facultative skin color adjusted by constitutive skin color was used to indicate tanning ability. Through linkage analysis and family-based association tests of 345 Mongolian subjects, we identified 2 potential linkage regions regulating tanning ability on 5q35.3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17.
authors: Institute of Dermatological Science, Seoul National University College of Medicine, Korea.
authors: Seung Hwan
authors: SH
authors: Paik
authors: Hyun-Jin
authors: HJ
authors: Kim
authors: Seungbok
authors: S
authors: Lee
authors: Sun-Wha
authors: SW
authors: Im
authors: Young Seok
authors: YS
authors: Ju
authors: Je Ho
authors: JH
authors: Yeon
authors: Seong Jin
authors: SJ
authors: Jo
authors: Hee Chul
authors: HC
authors: Eun
authors: Jeong-Sun
authors: JS
authors: Seo
authors: Jong-Il
authors: JI
authors: Kim
authors: Oh Sang
authors: OS
authors: Kwon
mesh_terms: D000328:Adult; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008543:Melanins / Q000378:metabolism; D008986:Mongolia; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055108:Sunbathing
chemical_list: D008543:Melanins