title: Impact of a prophylactic strategy on the incidence of nausea and vomiting after general surgery.
abstract: BACKGROUND
  This study aimed to evaluate the implementation of a strategy to prevent postoperative nausea and vomiting (PONV) in patients undergoing general surgery.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  A first period was observational. During a second period, a strategy to prevent PONV was based on five risk factors (RF) identified after the first phase. From two RF, antiemetic treatment was given according to the number of RF. The incidence of PONV was recorded in postoperative anaesthesic care unit (PACU) and at the 24th postoperative hour (24h).
  
  
  RESULTS
  We prospectively enrolled 823 patients. Implementation of a prophylactic PONV strategy was associated with a decrease of nausea in PACU from 29.9 to 9.8% (P<0.001) and at 24h from 19 to 10.3% (P<0.001). Vomiting decreased from 12.4 to 2.3% (P<0.001) in PACU and from 5.6 to 3.7% at 24h (non-significant).
  
  
  CONCLUSIONS
  Prophylaxis of PONV by the administration of antiemetic treatment according to a strategy based on a local risk score was efficient and associated with a significant decrease of PONV.
authors: Clinique d'anesthésie-réanimation, hôpital Claude-Huriez, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France.
authors: C
authors: C
authors: Mayeur
authors: E
authors: E
authors: Robin
authors: E
authors: E
authors: Kipnis
authors: B
authors: B
authors: Vallet
authors: G
authors: G
authors: Andrieu
authors: M
authors: M
authors: Fleyfel
authors: P
authors: P
authors: Petillot
authors: G
authors: G
authors: Lebuffe
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000517:prevention & control*; D011300:Preoperative Care; D011446:Prospective Studies; D013514:Surgical Procedures, Operative
chemical_list: D000932:Antiemetics