title: Analysis of direct medical care costs of peptic ulcer disease in a Korean tertiary medical center.
abstract: OBJECTIVE
  There have been no reported data on the medical care cost of idiopathic peptic ulcer disease (PUD) compared with H. pylori (+) and/or NSAID (+) cases although H. pylori-negative idiopathic ulcers are increasing. The aim of this study was to investigate the direct medical care costs of PUD based on whether it was H. pylori infection/from NSAIDs or idiopathic.
  
  
  METHODS
  One hundred and seventy three patients with PUD comprising H. pylori and/or NSAID use-associated PUD (n = 145) and idiopathic PUD (n = 28) were prospectively enrolled in this study. The direct medical care costs were analyzed retrospectively for the patients with PUD during a one-year follow-up period.
  
  
  RESULTS
  The recurrence rate within one year was significantly higher in idiopathic PUD than H. pylori and/or NSAID-associated PUD (p = 0.002). Direct medical care costs of idiopathic PUD ($2483.8) were higher than in patients with H. pylori and/or NSAID-associated PUD ($1751.8) resulting from longer duration of medication and higher proportion of endoscopic hemostasis and hospitalization.
  
  
  CONCLUSIONS
  More clinical research is needed to improve outcome and reduce recurrence rate and medical care costs of idiopathic PUD.
authors: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors: Jung Mook
authors: JM
authors: Kang
authors: Pyoung Ju
authors: PJ
authors: Seo
authors: Nayoung
authors: N
authors: Kim
authors: Byoung Hwan
authors: BH
authors: Lee
authors: Jinweon
authors: J
authors: Kwon
authors: Dong Ho
authors: DH
authors: Lee
authors: Hyun Chae
authors: HC
authors: Jung
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000191:economics* / Q000209:etiology* / Q000628:therapy; D012008:Recurrence; D056910:Republic of Korea; D012189:Retrospective Studies
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal