title: [A neuritogenic compound from Tremella fuciformis].
abstract: OBJECTIVE
  To search for low-molecular-weight neuritogenic compounds from the traditional Chinese medicine (TCM).
  
  
  METHODS
  An extract library of TCM was prepared. Targeted isolation guided by biological screening led to the discovery of compound 1, and its structure was elucidated by analysis of spectroscopic methods and comparison of spectroscopic data with these reported from the literature.
  
  
  RESULTS
  A neuritogenic compound 1, 3-O-beta-D-glucopyranosyl-22E, 24R-5alpha, 8alpha-epidioxyergosta-6, 22-diene, was isolated and identified from the methanol extract of T. fuciformis. This compound showed a significant neuritogenic activity against PC12 cells at 3 micromol x L(-1)).
  
  
  CONCLUSIONS
  Methonal extract of T. fuciformis and targeted compound 1 both showed significant neuritogenic activity against PC12 cells. These results suggested that the extract and compound 1 might be used to prevent and treat neurodegenerative disease such as Alzheimer's disease.
authors: College of Biology and Science, Sichuan Agricultural University, Yaan 625001, China.
authors: Yang
authors: Y
authors: Zhang
authors: Liang
authors: L
authors: Pei
authors: Lijuan
authors: L
authors: Gao
authors: Qianming
authors: Q
authors: Huang
authors: Jianhu
authors: J
authors: Qi
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D020932:Nerve Growth Factor