title: Different A-type natriuretic peptide level in five strains of mice.
abstract: Atrial (A-type) natriuretic peptide (ANP) is vasodilative hormone involved in the regulation of blood pressure and volume homeostasis. In this study, we examined the differences of the auricular and plasma ANP distribution by immunohistochemistry, ultrastructural morphometry, and radioimmunoassay in five strains of mice. The ANP-immunoreactivities of the auricle were most intense in ICR, and moderate in C57BL/6J and C3H/HeN, and weakest in BALB/cA and DBA/2Cr. The number of ANP-granules was greatest in ICR followed by C57BL, C3H or BALB/c, and DBA/2 mice, in this order. The auricular ANP content was highest in ICR, but the plasma ANP concentration was comparable in all strains. The present study demonstrates that there are differences in the ANP circulating system between five strains.
authors: Institute of Animal Experimentation, Kurume University School of Medicine, Fukuoka 830-0011, Japan. mifune@med.kurume-u.ac.jp
authors: Hiroharu
authors: H
authors: Mifune
authors: Yoshihiro
authors: Y
authors: Nishi
authors: Yuji
authors: Y
authors: Tajiri
authors: Akira
authors: A
authors: Yabuki
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D006325:Heart Atria / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron / Q000662:veterinary; D009206:Myocardium / Q000378:metabolism*; D011863:Radioimmunoassay / Q000662:veterinary
chemical_list: D009320:Atrial Natriuretic Factor