title: Effects of hepatitis C and HIV on cognition in women: data from the Women's Interagency HIV Study.
abstract: OBJECTIVE
  To compare neuropsychological scores in women infected with HIV, women infected with both HIV and hepatitis C, and uninfected subjects.
  
  
  BACKGROUND
  Some, but not all, studies have demonstrated that dual infection with Hepatitis C virus (HCV) and HIV has worse effects on cognition than infection with HIV alone.
  
  
  METHODS
  The Women's Interagency HIV Study is an ongoing prospective study of the natural history of HIV in women where participants are reevaluated every 6 months. In a cross-sectional analysis, we evaluated the effects of active HIV and HCV infections on scores on symbol-digit modalities test, the Stroop interference test, and trails A and B after controlling for age, ethnicity, education, depression, liver disease, and current or past substance abuse.
  
  
  RESULTS
  Data were available for 1338 women-17.8 % had detectable hepatitis C virus and 67% were HIV seropositive. In fully adjusted general linear models, HCV viremia was not associated with scores on any of the cognitive tests.
  
  
  CONCLUSIONS
  In this large sample of women, active HCV infection was not associated with scores on a small battery of neuropsychological tests.
authors: Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. howard.crystal@downstate.edu
authors: Howard
authors: H
authors: Crystal
authors: Inna
authors: I
authors: Kleyman
authors: Kathryn
authors: K
authors: Anastos
authors: Jason
authors: J
authors: Lazar
authors: Mardge
authors: M
authors: Cohen
authors: Chenglong
authors: C
authors: Liu
authors: Leigh
authors: L
authors: Pearce
authors: Elizabeth
authors: E
authors: Golub
authors: Victor
authors: V
authors: Valcour
authors: Ann
authors: A
authors: Ho
authors: Howard
authors: H
authors: Strickler
authors: Marion
authors: M
authors: Peters
authors: Andrea
authors: A
authors: Kovacs
authors: Susan
authors: S
authors: Holman
authors: Mary Jeanne
authors: MJ
authors: Kreek
authors: Jennifer
authors: J
authors: Manly
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000821:virology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents