title: Novel insights into the molecular mechanisms of HLA class I abnormalities.
abstract: Alterations in the MHC class I surface antigens represent one mechanism of tumor cells to escape from natural or immunotherapy-induced antitumor immune responses. In order to restore MHC class I expression, knowledge about the underlying molecular mechanisms of MHC class I defects in different tumor types is required. In most cases, abnormalities of MHC class I expression are reversible by cytokines suggesting a deregulation rather than structural abnormalities of members of the antigen-processing and presentation machinery (APM). The impaired expression of APM components could be controlled at the epigenetic, transcriptional and/or posttranscriptional level. Furthermore, a direct link between altered transcription factor binding, interferon signal transduction and MHC class I APM component expression has been shown, which might be further associated with cell cycle progression. This information will not only give novel insights into the (patho) physiology of the antigen-processing and presenting pathway, but will help in the future to design effective T cell-based immunotherapies.
authors: Institute of Medical Immunology, Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany. barbara.seliger@uk-halle.de.
authors: Barbara
authors: B
authors: Seliger
mesh_terms: D017951:Antigen Presentation; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007372:Interferons / Q000276:immunology*; D008213:Lymphocyte Activation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000276:immunology; D015533:Transcriptional Activation; D019139:Tumor Escape
chemical_list: D006680:HLA Antigens; D007372:Interferons