title: Therapeutic effects of intravenous infusion of hyperoxygenated solution on acute haemorrhagic shock in rabbits.
abstract: Tissue anoxia is the main mechanism of the shock reaction. Here, the effect of hyperoxygenated solution (HOS) on acute haemorrhagic shock was studied in rabbits. At 60 min after shock, rabbits were infused intravenously with hyperoxygenated solution at 10 (HOS1 group) or 20 ml/kg (HOS2  group) or with Ringer's solution at 10 ml/kg (RS group). Compared with values before shock, values after shock were lower for mean arterial pressure (MAP), more negative for base excess (BE) and higher for blood lactate (BL) and blood viscosity. After infusion, MAP declined more slowly in  the HOS1 and HOS2 groups than in the RS group. At 30 and 60 min after infusion, arterial partial pressure of oxygen (PaO(2)) and oxygen saturation (SaO(2)) were higher and BE was less negative in the HOS1 and HOS2 groups than in the RS group, BL was lower in the HOS1 and  HOS2 groups than in the RS group, and PaO(2) and SaO(2) were higher in the HOS2 group than in the HOS1 group. It was concluded that HOS infusion can rectify changes in vital signs more effectively than Ringer's solution after acute haemorrhagic shock in rabbits.
authors: Department of Anaesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: H
authors: H
authors: Xu
authors: L C
authors: LC
authors: Han
authors: W
authors: W
authors: Gao
authors: X X
authors: XX
authors: Sun
authors: Y
authors: Y
authors: Zhou
authors: X Z
authors: XZ
authors: Meng
authors: H
authors: H
authors: Zhang
authors: L X
authors: LX
authors: Xu
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001809:Blood Viscosity; D001810:Blood Volume; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D011817:Rabbits; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy*; D012996:Solutions
chemical_list: D012996:Solutions; D019344:Lactic Acid; D008315:Malondialdehyde; D010100:Oxygen