title: [Effects of the induction of anesthesia with propofol on hemodynamics in patients with Parkinson's disease].
abstract: BACKGROUND
  Patients with Parkinson's disease frequently suffer from impaired autonomic nervous function. To elucidate the effects of the induction of anesthesia with propofol on cardiovascular hemodynamics has become important, since the number of patients with Parkinson's disease undergoing deep brain stimulation under general anesthesia has increased recently.
  
  
  METHODS
  Effects of induction with propofol in patients with Parkinson's disease on cardiovascular hemodynamics and autonomic nervous activity were compared with those of the control patients. Moreover, possible different effect on hemodynamics between the propofol alone and the combination of propofol and fentanyl for the induction were examined in patients with Parkinson's disease.
  
  
  RESULTS
  Although heart rate or blood pressure was not different between patients with Parkinson's disease and the control patients before the induction, sympathetic vasomotor activity was lower in patients with Parkinson's disease than the control patients. The induction of anesthesia significantly decreased blood pressure in patients with Parkinson's disease. However the decreasing systolic blood pressure after the induction of anesthesia was more marked in patients with Parkinson's disease than the control patients. We did not find differences in the changes of blood pressure between the propofol alone and the combination of propofol and fentanyl in patients with Parkinson's disease.
  
  
  CONCLUSIONS
  No abnormal responses to the induction of anesthesia with propofol were found in the patients with Parkinson's disease.
authors: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo 173-8610.
authors: Ryo
authors: R
authors: Nakajima
authors: Jitsu
authors: J
authors: Kato
authors: Ken-ichi
authors: K
authors: Iwasaki
authors: Yojiro
authors: Y
authors: Ogawa
authors: Dai
authors: D
authors: Gokan
authors: Setsuro
authors: S
authors: Ogawa
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D017776:Autonomic Pathways / Q000503:physiopathology; D046690:Deep Brain Stimulation; D005260:Female; D005283:Fentanyl; D006439:Hemodynamics; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery; D015742:Propofol; D014666:Vasomotor System / Q000503:physiopathology
chemical_list: D005283:Fentanyl; D015742:Propofol