title: Risk of prostate cancer in a population-based cohort of men with coeliac disease.
abstract: BACKGROUND
  Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk.
  
  
  METHODS
  We identified 10,995 patients with CD who had undergone a small intestinal biopsy in 1969-2007. Statistics Sweden then identified 54,233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis.
  
  
  RESULTS
  During follow-up, 185 individuals with CD (expected n=200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79-1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100,000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy.
  
  
  CONCLUSIONS
  Our conclusion is that a CD diagnosis does not represent an increased risk for PC.
authors: Department of Paediatrics, Örebro University Hospital, Örebro 701 85, Sweden. jonasludvigsson@yahoo.com
authors: J F
authors: JF
authors: Ludvigsson
authors: K
authors: K
authors: Fall
authors: S
authors: S
authors: Montgomery
mesh_terms: D001706:Biopsy; D002446:Celiac Disease / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors