title: Lung malignancies after Hodgkin lymphoma: disease characteristics, detection methods and clinical outcome.
abstract: BACKGROUND
  Hodgkin lymphoma (HL) survivors have an increased risk of secondary malignancies. We analyzed outcomes in patients with lung cancers following HL treatment.
  
  
  METHODS
  Cases of thoracic malignancies were retrospectively identified from a multi-institutional database of 1976 patients treated for HL from 1969 to 2007. Data regarding risk factors, disease characteristics and outcomes were obtained from medical records.
  
  
  RESULTS
  Lung malignancies were identified in 55 patients a median of 19.5 years after initial HL therapy. Thirty-one patients (56%) had a >10 pack-year history of tobacco use, 48 (87%) received thoracic irradiation and 26 (47%) received alkylating chemotherapy. Of the 42 patients with known stage at lung cancer diagnosis, 23 (55%) were stage IV and 5 (12%) were stage III. The method of lung cancer detection was known for 35 patients; of these, 12 (34%) were detected incidentally. Median survival time after diagnosis was 10 months for all 55 patients. Median survival time for patients with incidentally detected tumors has not been reached with a median follow-up of 39 months.
  
  
  CONCLUSIONS
  Lung malignancies diagnosed in patients successfully treated for HL generally have a dismal prognosis. However, a subset of patients diagnosed incidentally may have potentially curable disease.
authors: Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA 02115, USA. jdschoenfeld@partners.org
authors: J D
authors: JD
authors: Schoenfeld
authors: P M
authors: PM
authors: Mauch
authors: P
authors: P
authors: Das
authors: B
authors: B
authors: Silver
authors: K J
authors: KJ
authors: Marcus
authors: M A
authors: MA
authors: Stevenson
authors: A K
authors: AK
authors: Ng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D033162:Incidental Findings; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000401:mortality; D012189:Retrospective Studies; D055815:Young Adult