title: Susceptibility to pulmonary tuberculosis in Iranian individuals is not affected by compound KIR/HLA genotype.
abstract: Natural killer (NK) cells have distinctive functional capacities that are likely to contribute both to innate and adaptive immunity to Mycobacterium tuberculosis. Killer cell immunoglobulin-like receptors (KIR) and their ligands, i.e. human leukocyte antigen (HLA) class I molecules contribute partly in regulation of NK cell activity. In this study, the impact of compound KIR/HLA genotype on susceptibility to pulmonary tuberculosis (TB) has been evaluated in Iranian individuals. A total of 107 TB patients and 100 matched healthy controls were genotyped for 17 KIR genes and their three major HLA class I ligand groups (-C1, -C2 and -Bw4: -B Bw4(Ile80) , -B Bw4(Thr80)  and -A Bw4) by a polymerase chain reaction-sequence-specific primers assay. Various analyses including distribution of KIR and HLA ligand genes and genotypes, frequency of inhibitory and activating KIR+HLA combinations and compound genotype status regarding balance of inhibitory and activating components showed no significant difference between patient and control groups. These findings may suggest that compound KIR/HLA genotype has no major impact on limiting Mycobacterium tuberculosis infection.
authors: Immunology Research Center (IRC), Tehran University of Medical Sciences, Tehran, Iran. ntajik@tums.ac.ir
authors: N
authors: N
authors: Tajik
authors: A
authors: A
authors: Shah-hosseini
authors: A
authors: A
authors: Mohammadi
authors: M
authors: M
authors: Jafari
authors: M
authors: M
authors: Nasiri
authors: M F
authors: MF
authors: Radjabzadeh
authors: P
authors: P
authors: Farnia
authors: A
authors: A
authors: Jalali
mesh_terms: D056704:Adaptive Immunity; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007492:Iran; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: D015395:Histocompatibility Antigens Class I; D054340:Receptors, KIR