title: Lithium in the treatment of neutropenia.
abstract: OBJECTIVE
  The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged.
  
  
  RESULTS
  We review the evidence that lithium increases granulocyte colony-stimulating factor (G-CSF) and augments G-CSF effects, showing its potential use in stem cell mobilization and engraftment of stem cell transplantation.
  
  
  CONCLUSIONS
  We suggest possible therapeutic uses of lithium in neutropenia. In bone marrow transplantation, preharvest lithium-assisted hematopoietic stem cell mobilization may be useful as well.
authors: Unit of Haematology, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa-AOUP, Pisa, Italy. mario.petrini@med.unipi.it
authors: Mario
authors: M
authors: Petrini
authors: Antonio
authors: A
authors: Azzarà
mesh_terms: D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D009503:Neutropenia / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016651:Lithium Carbonate