title: Polymorphic variant Ser128Arg of E-Selectin is associated with breast cancer risk and high grade tumors.
abstract: BACKGROUND
  The present study aimed to evaluate the association between the E-Selectin Ser128Arg polymorphism and breast cancer risk and clinicopathological characteristics of the patients.
  
  
  METHODS
  The genotypes of 387 breast cancer patients and 252 healthy women who had no history of any malignancy were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a hospital-based Malaysian population.
  
  
  RESULTS
  The frequency of the Arg allele was significantly (p = 0.030) higher in breast cancer patients than in healthy individuals. Women who were Ser/Arg heterozygotes (adjusted odds ratio (OR(adj)) = 1.607; 95% confidence interval (CI) = 1.008-2.564), and carriers of the Arg allele genotype (OR(adj) = 1.587; 95% CI = 1.037-2.430) or Arg allele (OR(adj) = 1.509; 95% CI = 1.040-2.189) showed a significantly increased risk of breast cancer. Patients who were carriers of the Arg allele genotype showed a significant association with poorly differentiated tumors (p = 0.002).
  
  
  CONCLUSIONS
  The Ser128Arg polymorphism might confer an increased susceptibility to breast cancer and contribute to aggressive phenotypic characteristics.
authors: School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Selangor Darul Ehsan, Malaysia. kdrakeshna@hotmail.com
authors: Rakesh
authors: R
authors: Naidu
authors: Yip C
authors: YC
authors: Har
authors: Nur A M
authors: NA
authors: Taib
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D019040:E-Selectin / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008875:Middle Aged; D060787:Neoplasm Grading; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D019040:E-Selectin; C546936:SELE protein, human