title: Fulminant gestational hepatitis due to primary herpes simplex type 2 infection: use of serum HSV polymerase chain reaction for noninvasive diagnosis.
abstract: Acute gestational hepatitis from herpes simplex virus (HSV) infection is a rare but potentially life-threatening condition. We present the first reported case of primary HSV type 2 hepatitis in a pregnant woman who was diagnosed by detection of HSV-2 viremia via real-time polymerase chain reaction. The patient was successfully treated with acyclovir and delivered a healthy infant.
authors: Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. nienaber.juhsien@mayo.edu
authors: Ju-Hsien J C
authors: JH
authors: Nienaber
authors: David R
authors: DR
authors: McNamara
authors: Ritu
authors: R
authors: Banerjee
authors: Bobbi S
authors: BS
authors: Pritt
authors: Tess
authors: T
authors: Karre
authors: Muhammad R
authors: MR
authors: Sohail
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006558:Herpes Genitalis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction / Q000379:methods*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D011256:Pregnancy Outcome; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir