title: Nanoporous polymeric nanofibers based on selectively etched PS-b-PDMS block copolymers.
abstract: One-dimensional nanoporous polymeric nanofibers have been fabricated within an anodic aluminum oxide (AAO) membrane by a facile approach based on selective etching of poly(dimethylsiloxane) (PDMS) domains in polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) block copolymers that had been formed within the AAO template. It was observed that prior to etching, the well-ordered PS-b-PDMS nanofibers are solid and do not have any porosity. The postetched PS nanofibers, on the other hand, had a highly porous structure having about 20-50 nm pore size. The nanoporous polymeric fibers were also employed as a drug carrier for the native, continuous, and pulsatile drug release using Rhodamine B (RB) as a model drug. These studies showed that enhanced drug release and tunable drug dosage can be achieved by using ultrasound irradiation.
authors: Bio-inspired Materials Research Laboratory (BIMREL), Department of Chemistry, Gazi University, 06500 Ankara, Turkey.
authors: Gokcen B
authors: GB
authors: Demirel
authors: Fatih
authors: F
authors: Buyukserin
authors: Michael A
authors: MA
authors: Morris
authors: Gokhan
authors: G
authors: Demirel
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D057139:Nanofibers / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004129:Dimethylpolysiloxanes; D004337:Drug Carriers; D011108:Polymers; D011137:Polystyrenes; D012235:Rhodamines; C013830:baysilon; C029773:rhodamine B; D000537:Aluminum Oxide