title: Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines.
abstract: The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship.
authors: Chemistry Centre, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors: Carla S
authors: CS
authors: Francisco
authors: Lígia R
authors: LR
authors: Rodrigues
authors: Nuno M F S A
authors: NM
authors: Cerqueira
authors: Ana M F
authors: AM
authors: Oliveira-Campos
authors: Lígia M
authors: LM
authors: Rodrigues
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins