title: An organoselenium compound inhibits Staphylococcus aureus biofilms on hemodialysis catheters in vivo.
abstract: Colonization of central venous catheters (CVCs) by pathogenic bacteria leads to catheter-related bloodstream infections (CRBSIs). These colonizing bacteria form highly antibiotic-resistant biofilms. Staphylococcus aureus is one of the most frequently isolated pathogens in CRBSIs. Impregnating CVC surfaces with antimicrobial agents has various degrees of effectiveness in reducing the incidence of CRBSIs. We recently showed that organoselenium covalently attached to disks as an antibiofilm agent inhibited the development of S. aureus biofilms. In this study, we investigated the ability of an organoselenium coating on hemodialysis catheters (HDCs) to inhibit S. aureus biofilms in vitro and in vivo. S. aureus failed to develop biofilms on HDCs coated with selenocyanatodiacetic acid (SCAA) in either static or flowthrough continuous-culture systems. The SCAA coating also inhibited the development of S. aureus biofilms on HDCs in vivo for 3 days. The SCAA coating was stable and nontoxic to cell culture or animals. This new method for coating the internal and external surfaces of HDCs with SCAA has the potential to prevent catheter-related infections due to S. aureus.
authors: Department of Ophthalmology & Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
authors: Phat L
authors: PL
authors: Tran
authors: Nathan
authors: N
authors: Lowry
authors: Thomas
authors: T
authors: Campbell
authors: Ted W
authors: TW
authors: Reid
authors: Daniel R
authors: DR
authors: Webster
authors: Eric
authors: E
authors: Tobin
authors: Arash
authors: A
authors: Aslani
authors: Thomas
authors: T
authors: Mosley
authors: Janet
authors: J
authors: Dertien
authors: Jane A
authors: JA
authors: Colmer-Hamood
authors: Abdul N
authors: AN
authors: Hamood
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D055499:Catheter-Related Infections / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000382:microbiology*; D004866:Equipment Contamination / Q000517:prevention & control; D016566:Organoselenium Compounds / Q000494:pharmacology*; D006435:Renal Dialysis / Q000295:instrumentation*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D016566:Organoselenium Compounds