title: Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau.
abstract: OBJECTIVE
  To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home.
  
  
  METHODS
  Children were enrolled on IPT if they were aged ≤ 5 years or 5-15 years and presented a tuberculin skin test induration of ≥ 10 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence.
  
  
  RESULTS
  A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged ≤ 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking > 80% of their doses. In all, 51% completed more than 6 consecutive months of IPT.
  
  
  CONCLUSIONS
  Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.
authors: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau. victorfranciscogomes@yahoo.co.uk
authors: V F
authors: VF
authors: Gomes
authors: C
authors: C
authors: Wejse
authors: I
authors: I
authors: Oliveira
authors: A
authors: A
authors: Andersen
authors: F J
authors: FJ
authors: Vieira
authors: L J
authors: LJ
authors: Carlos
authors: C S
authors: CS
authors: Vieira
authors: P
authors: P
authors: Aaby
authors: P
authors: P
authors: Gustafson
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau / Q000453:epidemiology; D006798:Housing; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D055118:Medication Adherence; D011446:Prospective Studies; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid