title: A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides.
abstract: Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.
authors: Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan. j.kondo@sophia.ac.jp
authors: Jiro
authors: J
authors: Kondo
mesh_terms: D000563:Amebicides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry / Q000187:drug effects / Q000235:genetics; D018360:Crystallography, X-Ray; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D008958:Models, Molecular; D009154:Mutation / Q000187:drug effects; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry / Q000235:genetics*
chemical_list: D000563:Amebicides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; C010680:antibiotic G 418