title: Profound urinary protein loss and acute renal failure caused by cyclooxygenase-2 inhibitor.
abstract: Cumulative evidence has shown that nonsteroidal anti-inflammatory drugs (NSAIDs) can induce acute renal failure and nephrotic-range proteinuria. Cyclooxygenase-2 (COX-2) inhibitors have less nephrotoxicity; however, recent data indicate that they may cause the same renal problems as NSAIDs do. Herein, we present a case of celecoxib-associated minimal change disease (MCD) with profound urinary protein loss and acute renal failure. Renal function and nephrotic syndrome in this patient resolved completely after discontinuation of celecoxib and treatment with methylprednisolone. Clinicians should keep high index of suspicions in patients developing nephrotic syndrome and acute renal failure after taking COX-2 inhibitors since secondary MCD responds well to timely cessation of COX-2 inhibitors and administration of steroid therapy.
authors: Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11221, Taiwan, Republic of China.
authors: Yu-Hsin
authors: YH
authors: Chen
authors: Der-Cherng
authors: DC
authors: Tarng
mesh_terms: D058186:Acute Kidney Injury; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D006801:Humans; D007668:Kidney; D008565:Membrane Proteins; D013449:Sulfonamides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D008565:Membrane Proteins; D013449:Sulfonamides; D051546:Cyclooxygenase 2; D000068579:Celecoxib