title: Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice.
abstract: Renal protective effects of naringenin at 0.5, 1, and 2% of the diet in diabetic mice were examined. Naringenin supplemented at 1 and 2% increased its deposit in liver and kidney of diabetic mice. Compared with the diabetic control group, naringenin treatments at 1 and 2% lowered plasma levels of glucose and blood urea nitrogen, as well as increased insulin level and creatinine clearance (P < 0.05). Naringenin treatments dose-dependently reduced renal tumor necrosis factor-α level and expression (P < 0.05) but only at 1 and 2% significantly decreased production and expression of interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1 (P < 0.05). Naringenin intake at 2% decreased renal formation and expression of type IV collagen, fibronectin, and transforming growth factor-β1 (P < 0.05). This compound at 1 and 2% lowered protein kinase C activity and suppressed nuclear factor κB (NF-κB) p65 activity, mRNA expression, and protein production in kidney. However, this agent only at 2% diminished NF-κB p50 activity, mRNA expression, and protein production (P < 0.05). These results indicate that naringenin could attenuate diabetic nephropathy via its anti-inflammatory and antifibrotic activities.
authors: School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.
authors: Shih-Jei
authors: SJ
authors: Tsai
authors: Chin-Shiu
authors: CS
authors: Huang
authors: Mei-Chin
authors: MC
authors: Mong
authors: Wing-Yiu
authors: WY
authors: Kam
authors: Hui-Ying
authors: HY
authors: Huang
authors: Mei-Chin
authors: MC
authors: Yin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D044950:Flavanones / Q000008:administration & dosage*; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology; D007668:Kidney / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D044950:Flavanones; D015850:Interleukin-6; C005273:naringenin