title: Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice.
abstract: Recent studies strongly support the hypothesis that an antioxidant diet inhibits the pathologic aging process as shown in senescence-accelerated mouse prone 8 (SAM/P-8). In our previous study in coral calcium hydride (CCH), we reported that a diet rich in antioxidants inhibited the pathologic aging process, increased the endogenous antioxidant ability, and contributed to prolonging the lifespan of SAM/P-8. To test the hypothesis that antioxidant CCH supplementation to SAM/P-8 mice would change the gene expression and to understand how CCH reverses the acceleration of aging in SAM/P-8 mice, we used a DNA array to compare the expression levels in the hippocampus of the brains from 16-week-old SAM/P-8 mice that were either treated or not treated with CCH. The most significant up-regulated changes in the gene network of SAM/P-8 mice were free radical scavenging and molecular transport, whereas genes associated with cell death, cancer, and cell cycle were down-regulated. Our findings regarding the changes in these messenger RNA might be associated with the inhibition of the acceleration of aging, as observed in SAM/P-8 mice fed a CCH diet.
authors: Department of Clinical Neuroscience, Section of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan. uedayuto@gmail.com
authors: Yuto
authors: Y
authors: Ueda
authors: Toshio
authors: T
authors: Kojima
authors: Taneaki
authors: T
authors: Oikawa
mesh_terms: D000375:Aging / Q000187:drug effects; D019588:Aging, Premature / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D037421:Anthozoa; D002118:Calcium / Q000008:administration & dosage*; D016923:Cell Death / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D004032:Diet; D015870:Gene Expression; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks / Q000235:genetics; D006624:Hippocampus / Q000378:metabolism*; D007109:Immunity / Q000235:genetics; D008297:Male; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D002118:Calcium