title: IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.
abstract: BACKGROUND
  The role of interleukin (IL) 13 and IL-17A in aspirin-exacerbated respiratory disease (AERD) remains unknown.
  
  
  OBJECTIVE
  To analyze the IL-13 and IL-17A gene polymorphisms in Japanese patients with AERD.
  
  
  METHODS
  The single-nucleotide polymorphisms in each gene were examined in patients with AERD, patients with aspirin-tolerant asthma (ATA), and healthy controls.
  
  
  RESULTS
  Frequencies of the TT/CT genotype of the IL-13 -1111C>T gene were higher than frequencies of the CC genotype in AERD patients compared with ATA patients (P < .001). In female patients with AERD, frequencies of the TT/CT genotype were higher than those of the CC genotype compared with female patients with ATA (P < .001). However, genotype frequencies of IL-13 Arg110Gln did not differ between AERD and ATA patients. Frequencies of the CC genotype of the IL-17A -737C>T gene were higher than those of the TT/CT genotype in AERD patients compared with ATA patients (P = .02). In female patients with AERD, frequencies of the CC genotype were higher than those of the TT/CT genotype compared with female patients with ATA (P = .03). Forced expiratory volume in 1 second (percentage predicted) in AERD patients with the CC genotype of the IL-13 -1111C>T gene was lower than that in the patients with the TT/CT genotype. AERD patients with the TT/CT genotype of the IL-17A -737C>T gene had a higher peripheral total eosinophil count compared with the patients with the CC genotype. The comparison of the clinical characteristics according to the IL-13 Arg110Gln gene polymorphism showed no difference.
  
  
  CONCLUSIONS
  These findings suggest that the IL-13 -1111C>T and IL-17A -737C>T gene sequence variations might have a role in the development of AERD.
authors: Gunma Institute for Allergy and Asthma, Gunma Hospital for Allergic and Respiratory Diseases, Ohra-machi, Gunma, Japan.
authors: Kenya
authors: K
authors: Kohyama
authors: Shyuzo
authors: S
authors: Abe
authors: Kazumi
authors: K
authors: Kodaira
authors: Tatsuo
authors: T
authors: Yukawa
authors: Soichiro
authors: S
authors: Hozawa
authors: Hironori
authors: H
authors: Sagara
authors: Motohiro
authors: M
authors: Kurosawa
mesh_terms: D055963:Asthma, Aspirin-Induced / Q000235:genetics* / Q000276:immunology*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004802:Eosinophilia / Q000097:blood; D005541:Forced Expiratory Volume / Q000276:immunology; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D018793:Interleukin-13 / Q000235:genetics* / Q000276:immunology*; D020381:Interleukin-17 / Q000235:genetics* / Q000276:immunology*; D007564:Japan; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: C508717:IL17A protein, human; D018793:Interleukin-13; D020381:Interleukin-17; D007073:Immunoglobulin E; D004247:DNA