title: Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.
abstract: OBJECTIVE
  FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.
  
  
  METHODS
  All studies published on the association between FTO-rs9939609 (or proxy [r (2) > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes.
  
  
  RESULTS
  The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10(-19)), overweight by 1.13-fold/allele (p = 1.0 × 10(-11)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10(-8)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 × 10(-5)). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m(2) per allele (p = 2.8 × 10(-17)), WHR by 0.003/allele (p = 1.2 × 10(-6)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12-20%) than South Asians (30-33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations.
  
  
  CONCLUSIONS
  FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI.
authors: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors: H
authors: H
authors: Li
authors: T O
authors: TO
authors: Kilpeläinen
authors: C
authors: C
authors: Liu
authors: J
authors: J
authors: Zhu
authors: Y
authors: Y
authors: Liu
authors: C
authors: C
authors: Hu
authors: Z
authors: Z
authors: Yang
authors: W
authors: W
authors: Zhang
authors: W
authors: W
authors: Bao
authors: S
authors: S
authors: Cha
authors: Y
authors: Y
authors: Wu
authors: T
authors: T
authors: Yang
authors: A
authors: A
authors: Sekine
authors: B Y
authors: BY
authors: Choi
authors: C S
authors: CS
authors: Yajnik
authors: D
authors: D
authors: Zhou
authors: F
authors: F
authors: Takeuchi
authors: K
authors: K
authors: Yamamoto
authors: J C
authors: JC
authors: Chan
authors: K R
authors: KR
authors: Mani
authors: L F
authors: LF
authors: Been
authors: M
authors: M
authors: Imamura
authors: E
authors: E
authors: Nakashima
authors: N
authors: N
authors: Lee
authors: T
authors: T
authors: Fujisawa
authors: S
authors: S
authors: Karasawa
authors: W
authors: W
authors: Wen
authors: C V
authors: CV
authors: Joglekar
authors: W
authors: W
authors: Lu
authors: Y
authors: Y
authors: Chang
authors: Y
authors: Y
authors: Xiang
authors: Y
authors: Y
authors: Gao
authors: S
authors: S
authors: Liu
authors: Y
authors: Y
authors: Song
authors: S H
authors: SH
authors: Kwak
authors: H D
authors: HD
authors: Shin
authors: K S
authors: KS
authors: Park
authors: C H D
authors: CH
authors: Fall
authors: J Y
authors: JY
authors: Kim
authors: P C
authors: PC
authors: Sham
authors: K S L
authors: KS
authors: Lam
authors: W
authors: W
authors: Zheng
authors: X
authors: X
authors: Shu
authors: H
authors: H
authors: Deng
authors: H
authors: H
authors: Ikegami
authors: G V
authors: GV
authors: Krishnaveni
authors: D K
authors: DK
authors: Sanghera
authors: L
authors: L
authors: Chuang
authors: L
authors: L
authors: Liu
authors: R
authors: R
authors: Hu
authors: Y
authors: Y
authors: Kim
authors: M
authors: M
authors: Daimon
authors: K
authors: K
authors: Hotta
authors: W
authors: W
authors: Jia
authors: J S
authors: JS
authors: Kooner
authors: J C
authors: JC
authors: Chambers
authors: G R
authors: GR
authors: Chandak
authors: R C
authors: RC
authors: Ma
authors: S
authors: S
authors: Maeda
authors: R
authors: R
authors: Dorajoo
authors: M
authors: M
authors: Yokota
authors: R
authors: R
authors: Takayanagi
authors: N
authors: N
authors: Kato
authors: X
authors: X
authors: Lin
authors: R J F
authors: RJ
authors: Loos
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human