title: Central nervous system regulation of food intake and energy expenditure: role of galanin-mediated feeding behavior.
abstract: Galanin is a neuropeptide widely expressed in the brain. It is implicated in energy expenditure, feeding, and the regulation of body weight. Numerous studies have revealed that galanin regulates food intake via galanin receptors, 5-HT(1A) receptor and adrenergic α-2 receptor. In this review, we summarize recent findings that reveal the essential role of galanin in increasing food intake as well as body weight and that identify the individual galanin receptor subtypes involved in the brain's modulation of food intake and energy expenditure, to provide a theoretical basis for further studies of different aspects of galanin action.
authors: Department of Physiology, Laboratory of Physiology, Laboratory of Pharmacy, School of Medicine, Yangzhou University, Yangzhou 225001, China.
authors: Peng-Hua
authors: PH
authors: Fang
authors: Mei
authors: M
authors: Yu
authors: Yin-Ping
authors: YP
authors: Ma
authors: Jian
authors: J
authors: Li
authors: Yu-Mei
authors: YM
authors: Sui
authors: Ming-Yi
authors: MY
authors: Shi
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects; D019004:Galanin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D051379:Mice; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D044088:Receptors, Galanin / Q000378:metabolism
chemical_list: D018341:Receptors, Adrenergic, alpha-2; D044088:Receptors, Galanin; D044282:Receptor, Serotonin, 5-HT1A; D019004:Galanin