title: Xenon for NMR biosensing--inert but alert.
abstract: NMR studies with hyperpolarized xenon as functionalized sensor or contrast agent recently made notable progress in developing a new approach for detecting molecular markers and parameters of biomedical interest. Combining spin polarization enhancement with novel indirect detection schemes easily enables a 10⁷-fold signal gain, thus having promising potential to solve the NMR sensitivity problem in many applications. Though an inert element, ¹²⁹Xe has exquisite NMR properties to sense molecular environments. This review summarizes recent developments in the production of hyperpolarized xenon and the design and detection schemes of xenon biosensors.
authors: ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie-FMP, Robert-Rössle-Str. 10, Berlin, Germany. lschroeder@fmp-berlin.de
authors: Leif
authors: L
authors: Schröder
mesh_terms: D000818:Animals; D001692:Biological Transport; D015374:Biosensing Techniques / Q000379:methods*; D055598:Chemical Phenomena; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D014978:Xenon / Q000737:chemistry*
chemical_list: D014978:Xenon