title: Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes.
abstract: Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.
authors: Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden. mats.bemark@immuno.gu.se
authors: M
authors: M
authors: Bemark
authors: J
authors: J
authors: Holmqvist
authors: J
authors: J
authors: Abrahamsson
authors: K
authors: K
authors: Mellgren
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D016175:B-Lymphocyte Subsets / Q000166:cytology*; D019070:Cell Lineage; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D016867:Immunocompromised Host; D007156:Immunologic Memory; D016130:Immunophenotyping; D007239:Infections / Q000209:etiology; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D008231:Lymphopenia / Q000209:etiology; D038041:Lymphopoiesis / Q000502:physiology*; D051379:Mice; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D017493:Leukocyte Common Antigens