title: Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta.
abstract: Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 (AQP4). More than 90% of NMO patients have relapse. Optimal treatments to prevent recurrence have not been established. Previous reports suggest that interferon beta (IFNB) has not been effective in NMO. However, we present a case of NMO with positive anti-myelin oligodendrocyte glycoprotein (MOG)(27-38) IgG and anti-AQP4 IgG treated with IFNB-1a successfully. The effect of IFNB on NMO and the role of anti-MOG antibodies in NMO deserve further study.
authors: Department of Neurology, Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, 100730 Beijing, China.
authors: Yan
authors: Y
authors: Xu
authors: Yao
authors: Y
authors: Zhang
authors: Jing
authors: J
authors: Ye
authors: Bin
authors: B
authors: Peng
authors: Jian-Ming
authors: JM
authors: Wang
authors: Li-Ying
authors: LY
authors: Cui
mesh_terms: D000368:Aged; D051401:Aquaporin 4 / Q000097:blood; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use*; D009471:Neuromyelitis Optica / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D013116:Spinal Cord / Q000473:pathology
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D007155:Immunologic Factors; D016899:Interferon-beta