title: Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.
abstract: Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors: Gang
authors: G
authors: Liu
authors: Ki Young
authors: KY
authors: Choi
authors: Ashwinkumar
authors: A
authors: Bhirde
authors: Magdalena
authors: M
authors: Swierczewska
authors: Juan
authors: J
authors: Yin
authors: Sang Wook
authors: SW
authors: Lee
authors: Jae Hyung
authors: JH
authors: Park
authors: Jong In
authors: JI
authors: Hong
authors: Jin
authors: J
authors: Xie
authors: Gang
authors: G
authors: Niu
authors: Dale O
authors: DO
authors: Kiesewetter
authors: Seulki
authors: S
authors: Lee
authors: Xiaoyuan
authors: X
authors: Chen
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D058726:Nanoconjugates / Q000737:chemistry*; D009369:Neoplasms / Q000235:genetics; D009942:Organometallic Compounds / Q000737:chemistry*; D010847:Picolines / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D058726:Nanoconjugates; D009942:Organometallic Compounds; D010847:Picolines; D034741:RNA, Small Interfering; C509592:zinc(II) dipicolylamine