title: Chemomodulatory potential of Glycine max against murine skin and cervical papillomagenesis.
abstract: In the present study, chemopreventive potential of Glycine max (G. Max) seeds was examined against DMBA-induced skin and MCA-induced cervical papillomagenesis in Swiss albino mice. Different doses (2.5, 5, and 7.5% w/w) of G. max were provided to animals in feed. Results exhibited a significant reduction in skin as well as cervical tumor incidence and tumor multiplicity (up to 75%) at all doses of test diet as compared to the control. Relatively, 7.5% test diet was most effective in protecting the animals against carcinogenesis. Further, detoxifying enzymes and antioxidative status was also evaluated in the liver of mice to understand the role of G. max in prevention of cancer. It was observed that the test diet containing G. max significantly elevated the specific activities of glutathione-S-transferase (GST), DT-diaphorase (DTD), superoxide dismutase (SOD), catalase (CAT), and glyoxalase I (Gly I). The test diet also elevated the content of reduced glutathione whereas it decreased the level of the peroxidative damage along with the specific activity of lactate dehydrogenase. It appeared that G. max seeds provided chemoprevention against skin and cervical papillomagenesis probably by modulating the detoxifying and antioxidative enzymes. It could be inferred that intake of G. max might help in reducing the risk of cancer.
authors: Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
authors: M
authors: M
authors: Singh
authors: E
authors: E
authors: Mendez
authors: A Ramesha
authors: AR
authors: Rao
authors: R K
authors: RK
authors: Kale
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D018890:Chemoprevention; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D007791:Lactoylglutathione Lyase / Q000378:metabolism; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D010212:Papilloma / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D013025:Glycine max / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*
chemical_list: D002273:Carcinogens; D010936:Plant Extracts; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D002374:Catalase; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone); D005982:Glutathione Transferase; D007791:Lactoylglutathione Lyase