title: Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae.
abstract: To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.
authors: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohoku University, Sendai, Miyagi, Japan.
authors: Tsutomu
authors: T
authors: Takahashi
authors: Shingo
authors: S
authors: Nakashima
authors: Takuro
authors: T
authors: Masuda
authors: Shigehiro
authors: S
authors: Yoneda
authors: Gi-Wook
authors: GW
authors: Hwang
authors: Akira
authors: A
authors: Naganuma
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D016213:Cyclins / Q000235:genetics; D004317:Doxorubicin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
chemical_list: D000903:Antibiotics, Antineoplastic; C082719:CLN1 protein, S cerevisiae; C082721:CLN2 protein, S cerevisiae; D016213:Cyclins; D029701:Saccharomyces cerevisiae Proteins; D004317:Doxorubicin; D006904:Hydroxymethylglutaryl-CoA Synthase