title: Necrotising fasciitis: an 8.5-year retrospective case review in a New Zealand intensive care unit.
abstract: BACKGROUND
  Necrotising fasciitis is a rare, rapidly progressive soft tissue infection associated with extensive necrosis, profound shock and high morbidity and mortality. Incidence worldwide is thought to be increasing.
  
  
  OBJECTIVE
  To investigate the demographics, comorbidities, microbiological features, resource use and outcome of patients with necrotising fasciitis. We aimed to identify factors associated with mortality.
  
  
  METHODS
  A retrospective case and chart review was performed in consecutive patients with necrotising fasciitis admitted to the intensive care unit of a tertiary hospital between January 2000 and June 2008.
  
  
  RESULTS
  58 patients with necrotising fasciitis were admitted during the study period. Pacific Islander and Maori peoples were overrepresented. Comorbidities were consistent with previous studies except for a high incidence of gout. Lower limb was the most frequent site of infection (53%). Swelling (83%) and severe pain (76%) were the most common presenting features. Type 2 infection (52%) was more common than type 1 (43%). Mortality was 29%. Recent non-steroidal antiinflammatory drug use was reported by 43% of patients but not associated with mortality. Logistic regression modelling identified Acute Physiology and Chronic Health Evaluation (APACHE) II score, pre-existing abnormal renal function and gout to be associated with mortality.
  
  
  CONCLUSIONS
  There is an higher incidence of necrotising fasciitis at our hospital in South Auckland than reported elsewhere. Maori and Pacific Islander people are at increased risk. In our patient sample APACHE II score, preexisting abnormal renal function and gout were associated with mortality.
authors: Middlemore Hospital, Auckland, New Zealand. Annemarie.Mitchell@middlemore.co.nz
authors: Annemarie
authors: A
authors: Mitchell
authors: Anthony
authors: A
authors: Williams
authors: Peter
authors: P
authors: Dzendrowskyj
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D015897:Comorbidity; D019115:Fasciitis, Necrotizing / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality / Q000628:therapy; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D010139:Pacific Islands / Q000453:epidemiology; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult