title: DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes.
abstract: The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO(3) (Oct-dtc = Octyldithiocarbamate and bpy = 2,2' -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO(3), have been synthesized and characterized by elemental analyses, molar conductivity measurements, IR, (1)H NMR, and electronic spectra studies. Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out. They show Ic(50) values lower than that of cisplatin. The complexes have been investigated for their interaction with calf thymus DNA (CT-DNA) by utilizing the electronic absorption spectroscopy, fluorescence spectra, and ethidium bromide displacement and gel filtration techniques. Both of these water-soluble complexes bound cooperatively and intercalatively to the CT-DNA at very low concentrations. Several binding and thermodynamic parameters are also described.
authors: Department of Chemistry, University of Sistan and Baluchestan, Zahedan 98167-45345, Iran.
authors: Hassan
authors: H
authors: Mansouri-Torshizi
authors: Maryam
authors: M
authors: Saeidifar
authors: Fatemeh
authors: F
authors: Khosravi
authors: Adeleh
authors: A
authors: Divsalar
authors: Ali Akbar
authors: AA
authors: Saboury
authors: Fatemeh
authors: F
authors: Hassani