title: Lipid peroxidation, DNA damage and coenzyme Q10 in lung cancer patients--markers for risk assessment?
abstract: OBJECTIVE
  Early diagnosis and prevention is very important for lung cancer patients. Previous studies have emphasized that the level of coenzyme Q10 (CoQ10), present primarily in mitochondria, decreases with age and is low in patients with chronic diseases. Our goal was to find out if there is any relationship between lung cancer and CoQ10 and lipid peroxidation levels.
  
  
  METHODS
  Blood samples from lung cancer patients were collected. Total and oxide CoQ10 levels, 8-OHdG (product of DNA damage), and malondialdehyde (MDA) levels (lipid peroxidation) were analyzed with high performance liquid chromatography (HPLC).
  
  
  RESULTS
  The MDA level (P<0.001) and DNA damage rate (8-OHdG) (P<0.001) was higher in cancer patients than in the control group; in contrast, theCoQ10 enzyme level was significantly lower (P<0.001).
  
  
  CONCLUSIONS
  The results suggest that the aforementioned parameters can be useful for lung cancer risk assessment.
authors: Department of Thoracic Surgery, Divison of Biochemistry, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: Ufuk
authors: U
authors: Cobanoglu
authors: Halit
authors: H
authors: Demir
authors: Aysegul
authors: A
authors: Cebi
authors: Fuat
authors: F
authors: Sayir
authors: Hamit Hakan
authors: HH
authors: Alp
authors: Zafer
authors: Z
authors: Akan
authors: Tugba
authors: T
authors: Gur
authors: Ebubekir
authors: E
authors: Bakan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008175:Lung Neoplasms / Q000175:diagnosis*; D008315:Malondialdehyde / Q000097:blood; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress; D018570:Risk Assessment / Q000379:methods; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D014451:Ubiquinone; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; C024989:coenzyme Q10; D003849:Deoxyguanosine