title: [Risk factors in the medical history of pregnant women undergoing congenital heart defect prenatal screening].
abstract: OBJECTIVE
  Evaluation of the congenital heart defects (CHDs) incidence and their prenatal detection rate in the Moravian-Silesian region. Presentation of fetal echocardiography as a screening method. Investigation of the relationship between risk factor and congenital heart defects.
  
  
  METHODS
  Long-term study between 1999-2009. Overall evaluation of CHDs incidence and their follow-up and analysis of their link to possible risk factors. The data were collected from medical notes of the gynecologist and pediatric cardiologist in the region. Fetal echocardiography was performed as a primary screening during the second term of pregnancy. A number of 22 743 pregnant women were included in the study. When any pregnancy pathology detected, more detailed examination followed (extracardial diseases, chromosomal aberrations).
  
  
  RESULTS
  In the observed period, there were a total of 453 significant CHD (3.55/1000 births). In prenatal phase 208 CHDs (45.9%) were diagnosed. At least one risk factor was mentioned in 15.9 % of the screened families. When compared with the group without and with any risk factor, the difference is significant (chi=7.28, p<0.0001). Mothers younger than 35 were compared with those aged 35 and older and the difference in values was not significant. However, generally, the probability of CHDs grow with age (GLM, z=2.468, p=0.013).
  
  
  CONCLUSIONS
  Prenatal detection of CHDs has the highest success rate as a rutine screening method during the second trimester of pregnancy. We confirmed the existence of a higher occurrence of the CHD in the group of pregnant women with a history of risk factors in comparison with the group without such a history. The risk families should be offered a detailed examination by paediatric cardiologist skilled in fetal echocardiography. Heart defects are the most common morphology anomalies, mostly occuring as an isolated issue.
authors: Oddelení detské a prenatální kardiologie FN Ostrava. jan.pavlicek@fno.cz
authors: J
authors: J
authors: Pavlícek
authors: T
authors: T
authors: Gruszka
authors: L
authors: L
authors: Jabůrek
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors; D016216:Ultrasonography, Prenatal