title: Palmaenones A and B, two new antimicrobial chlorinated cyclopentenones from discomycete Lachnum palmae.
abstract: Two new antimicrobial chlorinated cyclopentenones, palmaenones A (1) and B (2) were isolated from the culture broth of discomycete Lachnum palmae (NBRC-106495), and the structures of 1 and 2 were elucidated by spectroscopic data and the stereochemistry of 1 was directly determined by a single-crystal X-ray diffraction analysis. Palmaenones A (1) and B (2) are cyclopentenones containing three chlorines. Compound 1 exhibited potent antimicrobial activity against Micrococcus luteus, Mycobacterium smegmatis, Escherichia coli, Xanthomonas campestris, and Mucor racemosus, while the activities of compound 2 were weaker than 1.
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305–8572, Japan.
authors: Takunori
authors: T
authors: Matsumoto
authors: Tsuyoshi
authors: T
authors: Hosoya
authors: Hiroshi
authors: H
authors: Tomoda
authors: Motoo
authors: M
authors: Shiro
authors: Hideyuki
authors: H
authors: Shigemori
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D054879:Halogenation; D006801:Humans; D016982:Micrococcus luteus / Q000187:drug effects; D008958:Models, Molecular; D009089:Mucor / Q000187:drug effects; D009091:Mucormycosis / Q000188:drug therapy; D020102:Mycobacterium smegmatis / Q000187:drug effects; D016959:Xanthomonas campestris / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D003517:Cyclopentanes; C013905:cyclopentenone