title: Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron microscopic study.
abstract: Ovarian Brenner tumors are typically of surface epithelial-stromal origin; however, cases associated with mature cystic teratoma and/or struma ovarii possibly have a teratomatous derivation. Although argyrophil cells have been described in ovarian Brenner tumors and in urinary bladder epithelium, we are not aware of any previous reports of carcinoid arising from a malignant Brenner tumor of the ovary. In this study, we describe an 85-year-old woman who had a low-grade malignant Brenner tumor with progressive proliferation of neuroendocrine cells and transformation to trabecular carcinoid as demonstrated by immunocytochemistry and electron microscopy.
authors: Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. lroth@iupui.edu
authors: Lawrence Max
authors: LM
authors: Roth
authors: Michael P
authors: MP
authors: Goheen
authors: John R
authors: JR
authors: Broshears
mesh_terms: D000369:Aged, 80 and over; D001948:Brenner Tumor / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D002276:Carcinoid Tumor / Q000473:pathology* / Q000648:ultrastructure; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D055099:Neuroendocrine Cells; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D010053:Ovary / Q000473:pathology*; D013330:Struma Ovarii / Q000473:pathology