title: p53 overexpression impacts on the prognosis of laryngeal squamous cell carcinomas.
abstract: OBJECTIVE
  To investigate the prognostic implications of p53 expression in the surgical margins of laryngeal squamous cell carcinomas.
  
  
  METHODS
  Thirty one patients with T3-4N0M0 cancers with pathologically negative margins were analyzed by immunohistochemistry (IHC) to detect expression of p53.
  
  
  RESULTS
  The p53 positive rates by IHC in the surgical margin were 16.1% (5/31). In the p53 positive margin group, the recurrent rate was higher than those without (80% vs 19.2%, P = 0.006). Also, the median free of disease period in the p53 positive margin group was shorter than other group (22.2 vs 47.8 months, P < 0.0001).
  
  
  CONCLUSIONS
  We found that the overexpression of p53 can serve a prognostic role for both recurrence and disease-specific mortality in head and neck squamous cell carcinoma. p53 expression could stratify patients, in an easy and inexpensive way, according to their risk of local or regional recurrence.
authors: Otolaryngology, Head and Neck Surgery Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Guilan, Iran. mmjalali@gums.ac.ir
authors: Mir Mohammad
authors: MM
authors: Jalali
authors: Abtin
authors: A
authors: Heidarzadeh
authors: Mansour Jamali
authors: MJ
authors: Zavarei
authors: Hadi
authors: H
authors: Sarmast
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012907:Smoking; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53