title: One-year clinical and parasitological follow-up of dogs treated with marbofloxacin for canine leishmaniosis.
abstract: The purpose of this international, multicentric, and non-comparative field trial was to obtain complementary data on long-term clinical and parasitological follow-up of dogs treated with marbofloxacin for canine leishmaniosis (CanL). Seventy-four dogs with clinical signs of CanL and without severe renal failure were recruited in France, Spain and Italy, and 61 of them were part of the analysis. Each dog was treated with palatable tablets of marbofloxacin at 2 mg/kg once a day for 28 days. A clinical and parasitological follow-up was performed regularly up to 12 months. Efficacy was demonstrated in 42 dogs (68.9%), within 51 days (mean value), 10 of them (23.8%) being clinically cured after 3 months. A decrease of 61% in the sum of clinical scores was observed after 3 months. Haemato-biochemical parameters improved in general, supporting the observed clinical efficacy. Relapse was observed in 20/38 dogs (52.6%) approximately 5.5 months after treatment completion. The blood parasite load generally developed in conformity with the clinical outcome, even if exceptions were not rare. Lymph nodes remained positive by culture or PCR for a long time, even in dogs for which a good clinical response was observed. Despite the incomplete parasite clearance, as is also the case with other anti-leishmanial drugs, these results nevertheless confirm the relevance of marbofloxacin as a CanL treatment.
authors: Vétoquinol Laboratory, Magny Vernois, BP 189, 70204 Lure Cedex, France. sandrine.rougier@vetoquinol.com
authors: Sandrine
authors: S
authors: Rougier
authors: Lilia
authors: L
authors: Hasseine
authors: Pascal
authors: P
authors: Delaunay
authors: Grégory
authors: G
authors: Michel
authors: Pierre
authors: P
authors: Marty
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004334:Drug Administration Schedule; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D007896:Leishmaniasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D012698:Serologic Tests
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C080260:marbofloxacin