title: Assessment of cochlear and auditory pathways in patients with migraine.
abstract: OBJECTIVE
  In this study, we aimed to determine the function of the cochlea and peripheral and central auditory pathways with migraine.
  
  
  METHODS
  Fifty-eight patients with migraine and 40 healthy subjects were assessed using routine diagnostic audiometry along with transient evoked otoacoustic emissions (TOAEs), distortion product otoacoustic emissions (DPOAEs), and auditory brainstem response (ABR) at high and low repetition rate frequencies.
  
  
  RESULTS
  Nearly two thirds of patients with migraine had one or more abnormalities in electrophysiological testing. Compared with control subjects, patients reported significant lowering of TOAEs amplitude at frequencies of 1 kHz (right: P = .0003; left: P = .002), 3 kHz (right: P = .025), and 4 kHz (right: P = .019); prolonged wave III latency (right: P = .009); and I-V interpeak latency (IPL) (left: P = .024) at high repetition rate frequencies. Significant correlations were identified between age, duration of illness and frequency of migraine and TOAEs total response and at amplitude of 4 kHz, amplitudes of DPOAEs at 1, 1.5, 2, 3, and 5 kHz and I, III and wave latencies and I-V IPL of ABR at high rate frequencies.
  
  
  CONCLUSIONS
  These data suggest that subclinical changes in cochlear function and auditory pathways are associated with chronic migraine. It is possible that migraine could be accompanied by compromise of blood supply of auditory system.
authors: Department of Neurology and Psychiatry, Assiut University Hospital, Egypt. hamed_sherifa@yahoo.com
authors: Sherifa Ahmad
authors: SA
authors: Hamed
authors: Ahmed Hamdy
authors: AH
authors: Youssef
authors: Amal Mohammad
authors: AM
authors: Elattar
mesh_terms: D000328:Adult; D001299:Audiometry; D001306:Auditory Pathways / Q000503:physiopathology*; D016022:Case-Control Studies; D002908:Chronic Disease; D003051:Cochlea / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D018709:Statistics, Nonparametric