title: Cellular mechanotransduction: filamin A strains to regulate motility.
abstract: A new study suggests that mechanical strain through the actin-binding protein filamin A leads to increased linkage between the extracellular matrix and cytoskeleton and decreased actin dynamics.
authors: Department of Biological Sciences, Columbia University, New York, NY, USA.
authors: Christopher D
authors: CD
authors: Lynch
authors: Michael P
authors: MP
authors: Sheetz
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D003285:Contractile Proteins / Q000737:chemistry / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D064448:Filamins; D006801:Humans; D039641:Integrin beta Chains / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits
chemical_list: D003285:Contractile Proteins; D064448:Filamins; D039641:Integrin beta Chains; D008840:Microfilament Proteins; C091368:integrin beta7