title: Biomarkers of cervical dysplasia and carcinoma.
abstract: Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential for either under- or overtreatment of women due to decreased specificity of screening tests as well as significant interobserver variability in the diagnosis of cervical dysplastic lesions. Although not completely elucidated, the HPV-driven molecular mechanisms underlying the development of cervical lesions have provided a number of potential biomarkers for both diagnostic and prognostic use in the clinical management of these women.
authors: Department of Pathology, Hospital Level 2, Room 766, Stony Brook University Medical Center, Stony Brook, NY 11794-7025, USA.
authors: Sonya J
authors: SJ
authors: Hwang
authors: Kenneth R
authors: KR
authors: Shroyer