title: Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology.
abstract: Growing evidence supports that mitochondrial calcium uptake is important for cell metabolism, signaling and survival. However, both the molecular nature of the mitochondrial Ca(2+) transport sites and the calcium signals they respond to remained elusive. Recent RNA interference studies have identified new candidate proteins for Ca(2+) transport across the inner mitochondrial membrane, including LETM1, MCU, MICU1 and NCLX. The sensitivity of these factors to several drugs has been tested and in parallel, some new inhibitors of mitochondrial Ca(2+) uptake have been described. This paper provides an update on the pharmacological aspects of the molecular mechanisms of the inner mitochondrial membrane Ca(2+) transport.
authors: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Gyorgy.Csordas@jefferson.edu
authors: György
authors: G
authors: Csordás
authors: Peter
authors: P
authors: Várnai
authors: Tünde
authors: T
authors: Golenár
authors: Shey-Shing
authors: SS
authors: Sheu
authors: György
authors: G
authors: Hajnóczky
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000187:drug effects / Q000502:physiology; D033681:Mitochondrial Membrane Transport Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D033681:Mitochondrial Membrane Transport Proteins; D002118:Calcium