title: Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders.
abstract: BACKGROUND
  The mechanisms underlying the development of impulse control disorders (ICDs) like compulsive gambling, buying, sexual, and eating behaviors in Parkinson's disease (PD) are debated. We assessed whether allelic variants of dopamine D2 receptors (DRD2), catechol-O-methyltransferase (COMT) and dopamine transporter (DAT) were associated with the development of ICDs in PD.
  
  
  METHODS
  We enrolled 89 idiopathic PD patients (48 without ICDs and 41 with ICDs). All patients were screened with the Minnesota Impulsive Disorders Interview (MIDI) and fulfilled DSM-IV criteria for the ICD positive cohort. Differences in the frequency of the genotypes between ICDs and non-ICDs groups were assessed using the χ(2) test.
  
  
  RESULTS
  Genotyping was performed for variants of the DRD2 Taq1A (rs1800497), COMT Val(158)Met (rs4680), DAT1 (3' UTR 40bp VNTR). Variants of DRD2 Taq1A, COMT and DAT1 were not associated with the risk of developing ICDs.
  
  
  CONCLUSIONS
  In our study, there were no differences in the frequency of variant of DRD2 Taq1A, COMT and DAT1 between the two groups. Polymorphisms of dopaminergic genes do not play a relevant role in the development of ICD in PD suggesting that ICD originate from inability to filter inappropriate behaviors triggered by dopaminergic therapy.
authors: Molecular Neurobiology Laboratory, IRCCS San Camillo, via Alberoni 70, 35126 Venice Lido, Italy. biologia.molecolare@ospedalesancamillo.net
authors: Annamaria
authors: A
authors: Vallelunga
authors: Raffaella
authors: R
authors: Flaibani
authors: Patrizia
authors: P
authors: Formento-Dojot
authors: Roberta
authors: R
authors: Biundo
authors: Silvia
authors: S
authors: Facchini
authors: Angelo
authors: A
authors: Antonini
mesh_terms: D000368:Aged; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D015331:Cohort Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000209:etiology*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D001068:Feeding and Eating Disorders / Q000209:etiology; D005260:Female; D005715:Gambling / Q000209:etiology; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D010300:Parkinson Disease / Q000150:complications* / Q000235:genetics*; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; D002394:Catechol O-Methyltransferase