title: Total synthesis of hapalindoles J and U.
abstract: The total synthesis of D,L-hapalindoles J and U has been accomplished. Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially available materials. The route employs a novel silyl ether-based strategy for accessing the 6:5:6:6 ring system of the hapalindoles rapidly and in good yields.
authors: Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, Colorado 80523, United States.
authors: Ryan J
authors: RJ
authors: Rafferty
authors: Robert M
authors: RM
authors: Williams
mesh_terms: D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D026121:Indole Alkaloids; D007211:Indoles; C572544:hapalindole J; C518617:hapalindole U