title: Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities?
abstract: Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the commonest cause of exercise-related sudden cardiac death in young individuals. Most deaths have been reported in intermittent 'start-stop' sports such as football (soccer) and basketball. The theory is that individuals with HCM are unable to augment stroke volume sufficiently to meet the demands of endurance sports and are accordingly 'selected-out' of participation in such events. We report the case of an ultra-endurance athlete with 25 years of > 50 km competitive running experience, with genetically confirmed HCM; thereby demonstrating that these can be two compatible entities.
authors: St George's University of London, Division of Cardiac & Vascular Sciences, London, UK.
authors: Mathew G
authors: MG
authors: Wilson
authors: Navin
authors: N
authors: Chandra
authors: Michael
authors: M
authors: Papadakis
authors: Rory
authors: R
authors: O'Hanlon
authors: Sanjay K
authors: SK
authors: Prasad
authors: Sanjay
authors: S
authors: Sharma
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D002352:Carrier Proteins / Q000235:genetics; D004252:DNA Mutational Analysis; D018618:Echocardiography, Doppler, Color; D004562:Electrocardiography; D005080:Exercise Test; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009154:Mutation; D010641:Phenotype; D010807:Physical Endurance; D012420:Running; D000099163:Myosin Binding Protein C
chemical_list: D002352:Carrier Proteins; D000099163:Myosin Binding Protein C