title: The levels of zearalenone and its metabolites in plasma, urine and faeces of horses fed with naturally, Fusarium toxin-contaminated oats.
abstract: Concentration profile of zearalenone (ZON) and its metabolites in plasma, urine and faeces samples of horses fed with Fusarium toxin-contaminated oats is described. In plasma, β-zearalenol (β-ZOL) was detected at high levels on day 10 of the study (3.21-6.24 μg/l). β-Zearalenol and α-zearalenol were the major metabolites in urine. Zearalenone, α-ZOL and β-ZOL were predominantly found in faeces. Zearalanone could also be detected in urine (1.34-5.79 μg/l) and faeces (1 μg/kg). The degree of glucuronidation was established in all sample types, approximately 100% in urine and plasma. Low per cent of glucuronidation (4-15%) was found in faeces samples. The results indicate the main conversion of ZON into β-ZOL in horse. This finding could explain why horse is not susceptible to ZON in comparison with swine which produce α-ZOL as a predominant metabolite.
authors: Institute of Animal Nutrition, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinä rplatz 1,Vienna, Austria.
authors: P
authors: P
authors: Songsermsakul
authors: J
authors: J
authors: Böhm
authors: C
authors: C
authors: Aurich
authors: J
authors: J
authors: Zentek
authors: E
authors: E
authors: Razzazi-Fazeli
mesh_terms: D000818:Animals; D005243:Feces / Q000737:chemistry*; D005260:Female; D005670:Fusarium / Q000378:metabolism*; D006736:Horses / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013045:Species Specificity; D015025:Zearalenone / Q000097:blood* / Q000737:chemistry / Q000378:metabolism* / Q000652:urine
chemical_list: D015025:Zearalenone