title: International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18.
abstract: This international field validation study examined the psychometric properties and clinical validity of the European Organization for Research and Treatment of Cancer (EORTC) questionnaire module for hepatocellular carcinoma (HCC), the EORTC quality-of-life questionnaire (QLQ)-HCC18. The EORTC QLQ-HCC18 was administered with the core questionnaire, the EORTC QLQ-C30, to 272 patients from seven centers in 6 countries. Patient acceptability of the module was examined with a debriefing questionnaire, and psychometric and clinical properties were assessed. Multitrait scaling analyses confirmed the hypothesized scale structure without any scaling error, and the fatigue scale demonstrated satisfactory internal consistency. The test-retest reliability scores were high for all scales, except abdominal swelling and sexual interest. The correlations between all scales of the QLQ-HCC18 and the QLQ-C30 were low or moderate, and many scales could distinguish patients with different clinical conditions. The module demonstrated responsiveness to clinical change in pain before and after surgery and some borderline change in patients undergoing systemic treatment.
  
  
  CONCLUSIONS
  The EORTC QLQ-HCC18 can be used as a supplementary module for the EORTC QLQ-C30 in clinical trials for patients with HCC.
authors: Graduate Institute of Epidemiology and Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. weichu@ntu.edu.tw
authors: Wei-Chu
authors: WC
authors: Chie
authors: Jane M
authors: JM
authors: Blazeby
authors: Chin-Fu
authors: CF
authors: Hsiao
authors: Herng-Chia
authors: HC
authors: Chiu
authors: Ronnie T
authors: RT
authors: Poon
authors: Naoko
authors: N
authors: Mikoshiba
authors: Gillian
authors: G
authors: Al-Kadhimi
authors: Nigel
authors: N
authors: Heaton
authors: Jozer
authors: J
authors: Calara
authors: Peter
authors: P
authors: Collins
authors: Katharine
authors: K
authors: Caddick
authors: Anna
authors: A
authors: Costantini
authors: Valerie
authors: V
authors: Vilgrain
authors: Ludovic
authors: L
authors: Trinquart
authors: Chieh
authors: C
authors: Chiang
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000523:psychology* / Q000628:therapy*; D005060:Europe; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007391:International Cooperation; D008113:Liver Neoplasms / Q000523:psychology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents