title: Mesoporous multifunctional upconversion luminescent and magnetic "nanorattle" materials for targeted chemotherapy.
abstract: Nanorattles consisting of hydrophilic, rare-earth-doped NaYF(4) shells each containing a loose magnetic nanoparticle were fabricated through an ion-exchange process. The inner magnetic Fe(3)O(4) nanoparticles are coated with a SiO(2) layer to avoid iron leaching in acidic biological environments. This multifunctional mesoporous nanostructure with both upconversion luminescent and magnetic properties has excellent water dispersibility and a high drug-loading capacity. The material emits visible luminescence upon NIR excitation and can be directed by an external magnetic field to a specific target, making it an attractive system for a variety of biological applications. Measurements on cells incubated with the nanorattles show them to have low cytotoxicity and excellent cell imaging properties. In vivo experiments yield highly encouraging tumor shrinkage with the antitumor drug doxorubicin (DOX) and significantly enhanced tumor targeting in the presence of an applied magnetic field.
authors: Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People's Republic of China. zhang_fan@fudan.edu.cn
authors: Fan
authors: F
authors: Zhang
authors: Gary B
authors: GB
authors: Braun
authors: Alessia
authors: A
authors: Pallaoro
authors: Yichi
authors: Y
authors: Zhang
authors: Yifeng
authors: Y
authors: Shi
authors: Daxiang
authors: D
authors: Cui
authors: Martin
authors: M
authors: Moskovits
authors: Dongyuan
authors: D
authors: Zhao
authors: Galen D
authors: GD
authors: Stucky
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage*; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity
chemical_list: D000903:Antibiotics, Antineoplastic; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D004317:Doxorubicin