title: Effect of vitamin E supplementation on carbogen-induced amelioration of noise induced hearing loss in man.
abstract: The study explores the effect of occupational noise on oxidative stress status and prophylactic effect of Vitamin E and carbogen (5% CO 2 +95%O 2 ) breathing in alleviating the oxidative damage and conserving the hearing in human volunteers exposed to intense occupational noise. Plasma total antioxidant status, blood glutathione (GSH), malondialdehyde (MDA), antioxidant enzyme activities of GSH peroxidase (EC 1.11.1.9, GPx), superoxide dismutase (EC 1.15.1.1; SOD) in erythrocytes, nitric oxide and nitric oxide synthase in plasma were assessed before and after 6 days of administration of Vitamin E and Carbogen. Results of the study indicate that the exposure to noise for 6 days increased blood concentration of MDA, decreased concentrations of reduced GSH, antioxidant enzyme activity of SOD and plasma total antioxidant status in control (noise) group. Vitamin E- supplemented group showed decline in oxidative stress reflected by significant decrease in blood concentration of MDA and increase in antioxidant enzyme activity of erythrocyte SOD. Results of audiometric studies revealed that breathing of carbogen prevented the development of temporary threshold shift; thereby reducing the risk of noise induced hearing loss.
authors: Defence Institute of Physiology and Allied Sciences, Ministry of Defence, Timarpur, Delhi, India. neeru0260@gmail.com
authors: Neeru
authors: N
authors: Kapoor
authors: Kumar Vyonkesh
authors: KV
authors: Mani
authors: Radhey
authors: R
authors: Shyam
authors: Raj Kumar
authors: RK
authors: Sharma
authors: Ambika Prasad
authors: AP
authors: Singh
authors: William
authors: W
authors: Selvamurthy
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000704:Analysis of Variance; D001299:Audiometry; D001774:Blood Chemical Analysis; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D005978:Glutathione / Q000097:blood / Q000502:physiology; D006317:Hearing Loss, Noise-Induced / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008889:Military Personnel; D009569:Nitric Oxide / Q000097:blood / Q000502:physiology; D009623:Noise, Occupational / Q000009:adverse effects* / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood / Q000502:physiology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D002245:Carbon Dioxide; D009569:Nitric Oxide; D008315:Malondialdehyde; C011700:carbogen; D013482:Superoxide Dismutase; D005978:Glutathione; D010100:Oxygen