title: Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus.
abstract: OBJECTIVE
  To report refractive, topographic, and biomechanical outcomes, efficiency, and safety of corneal collagen crosslinking (CXL) 1, 3, 6, and 12 months after treatment.
  
  
  METHODS
  National Reference Centre for Keratoconus, Bordeaux and Toulouse, France.
  
  
  METHODS
  Case series.
  
  
  METHODS
  This retrospective uncontrolled double-center study comprised eyes with progressive keratoconus. Uncorrected distance visual acuity, corrected distance visual acuity (CDVA), corneal pachymetry, endothelial cell count, and corneal hysteresis and corneal resistance factor were evaluated at baseline and at 1, 3, 6, and 12 months.
  
  
  RESULTS
  One hundred forty-two eyes were enrolled in the study. At 6 months, the CDVA had stabilized in 53 eyes (48.1%), improved in 36 eyes (32.7%), and decreased in 18 eyes (16.3%). At 12 months, the CDVA had stabilized in 31 eyes (47.6%), improved in 26 eyes (40.0%), and decreased in 8 eyes (12%). At 6 months, keratoconus progression had stopped in 51 eyes (49.03%) and the maximum keratometry (K) value had decreased by more than 1.0 diopter (D) in 37 eyes (35.5%); it continued to progress in 16 eyes (15.3%). At 12 months, keratoconus progression had stopped in 42 eyes (68.8%) and the maximum K value had decreased by more than 2.0 D in 13 eyes (21.3%). The complication rate with loss of vision was 3.5%.
  
  
  CONCLUSIONS
  Ultraviolet-A light associated with riboflavin CXL is an efficient procedure to stabilize and improve progressive keratoconus. The results reinforce previous studies highlighting the efficacy and safety of the procedure. A large prospective randomized clinical trial is needed.
authors: Centre de Référence National du Kératocône de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Site Pellegrin, Centre Franҫois Xavier Michelet, Service d'Ophtalmologie, Bordeaux, France.
authors: Dalal
authors: D
authors: Asri
authors: David
authors: D
authors: Touboul
authors: Pierre
authors: P
authors: Fournié
authors: Florence
authors: F
authors: Malet
authors: Caroline
authors: C
authors: Garra
authors: Anne
authors: A
authors: Gallois
authors: François
authors: F
authors: Malecaze
authors: Joseph
authors: J
authors: Colin
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology; D002452:Cell Count; D003094:Collagen / Q000378:metabolism*; D055954:Corneal Endothelial Cell Loss / Q000503:physiopathology; D003319:Corneal Stroma / Q000378:metabolism*; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000627:therapeutic use; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D012256:Riboflavin / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin