title: Anti-NMDA receptor encephalitis presenting with focal non-convulsive status epilepticus in a child.
abstract: A previously healthy 9-year-old girl presented to an emergency department (ED) with headache, dizziness, blurry vision, and abnormal visual perceptions. She was diagnosed with migraine, treated symptomatically, and discharged. Over the course of days, she became progressively somnolent, and returned to the ED, where she was found to have a right inferior quadrantanopsia and sixth nerve palsy. Magnetic resonance imaging (MRI) of the brain showed gyral swelling of the left parieto-occipital lobe. Continuous electroencephalogram (EEG) monitoring revealed focal non-convulsive status epilepticus (NCSE) in the left occipital region. Cerebrospinal fluid (CSF) was positive for antibodies directed against the N-methyl-d-aspartate receptor (NMDAR). This case is the first report of anti-NMDAR encephalitis presenting with focal non-convulsive status epilepticus (NCSE).
authors: Department of Neurology, The Hospital of the University of Pennsylvania, Philadelphia, PA, USA. goldberge@email.chop.edu
authors: E M
authors: EM
authors: Goldberg
authors: K S
authors: KS
authors: Taub
authors: S K
authors: SK
authors: Kessler
authors: N S
authors: NS
authors: Abend
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000927:Anticonvulsants; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors