title: [Lung volume reduction surgery for severe pulmonary emphysema in Iceland].
abstract: Lung volume reduction surgery (LVRS) can benefit patients with severe emphysema. The aim of this study was to evaluate the outcome of LVRS performed in Iceland.
  
  
  
  A prospective study of 16 consecutive patients who underwent bilateral LVRS through median sternotomy between January 1996 and December 2008. All patients had disabling dyspnea, lung hyperinflation, and emphysema with upper lobe predominance. Preoperatively all patients underwent pulmonary rehabilitation. Spirometry, lung volumes, arterial blood gases and exercise capacity were measured before and after surgery. Mean follow-up time was 8.7 years.
  
  
  
  Mean age was 59.2 ± 5.9 years. All patients had a history of heavy smoking. There was no perioperative mortality and survival was 100%, 93%, and 63% at 1, 5, and 10 years, respectively. The forced expiratory volume in 1 second (FEV1) and the forced vital capacity (FVC) improved significantly after surgery by 35% (p<0.001) and 14% (p<0.05), respectively. The total lung capacity, residual volume and partial pressure of CO2 also showed statistically significant improvements but exercise capacity, O2 consumption and diffusing capacity of the lung for CO did not change. Prolonged air leak (≥ 7 days) was the most common complication (n=7). Five patients required reoperation, most commonly for sternal dehiscence (n=4).
  
  
  
  In this small prospective study, FEV1 and FVC increased and lung volumes and PaCO2 improved after LVRS. Long term survival was satisfactory although complications such as reoperations for sternal dehiscence were common and hospital stay therefore often prolonged.
authors: Hjarta-og lungnaskurodelid.
authors: Sverrir I
authors: SI
authors: Gunnarsson
authors: Kristinn B
authors: KB
authors: Johannsson
authors: Marta
authors: M
authors: Guðjónsdóttir
authors: Steinn
authors: S
authors: Jónsson
authors: Hans J
authors: HJ
authors: Beck
authors: Bjorn
authors: B
authors: Magnusson
authors: Tomas
authors: T
authors: Gudbjartsson
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D005080:Exercise Test; D017079:Exercise Tolerance; D006801:Humans; D007055:Iceland; D007902:Length of Stay; D008168:Lung / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D011013:Pneumonectomy; D011446:Prospective Studies; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function; D012086:Reoperation; D012720:Severity of Illness Index; D013147:Spirometry; D056346:Sternotomy; D013997:Time Factors; D016896:Treatment Outcome