title: Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status.
abstract: BACKGROUND
  The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters.
  
  
  METHODS
  A total of 80 dental implants (mean time of loading, 4.16 ± 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples.
  
  
  RESULTS
  HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis.
  
  
  CONCLUSIONS
  The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.
authors: Department of Periodontics, School of Dentistry, University of Belgrade, Belgrade, Serbia. drsashaj@gmail.com
authors: S
authors: S
authors: Jankovic
authors: Z
authors: Z
authors: Aleksic
authors: B
authors: B
authors: Dimitrijevic
authors: V
authors: V
authors: Lekovic
authors: I
authors: I
authors: Milinkovic
authors: B
authors: B
authors: Kenney
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000235:genetics* / Q000302:isolation & purification; D015921:Dental Implants / Q000009:adverse effects; D003773:Dental Plaque / Q000821:virology; D003774:Dental Plaque Index; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D009061:Mouth Mucosa / Q000821:virology; D052016:Mucositis / Q000209:etiology / Q000821:virology; D057873:Peri-Implantitis / Q000821:virology*; D010512:Periodontal Index; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013280:Stomatitis / Q000209:etiology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D015921:Dental Implants