title: Ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones and silica chloride mediated conversion to its piperidin-4-ols: synthesis and structural confinements.
abstract: The ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones was carried out by the reaction of 4-piperidone hydrochloride monohydrate with different alkylating and acylating agents. It was preferably reduced to respective piperidin-4-ols by ultrasonic irradiation using silica chloride, which maintains higher yields by acting as an effective supporting polymer. The sterically hindered phthaloyl derivative of piperidin-4-one was synthesized by ultrasonic irradiation which was difficult by conventional methods.
authors: Synthetic Organic Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India.
authors: K
authors: K
authors: Rajesh
authors: B
authors: B
authors: Palakshi Reddy
authors: V
authors: V
authors: Vijayakumar
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry* / Q000528:radiation effects; D002712:Chlorides / Q000737:chemistry* / Q000528:radiation effects; D019220:High-Energy Shock Waves; D010880:Piperidines / Q000138:chemical synthesis* / Q000528:radiation effects; D011829:Radiation Dosage; D012822:Silicon Dioxide / Q000737:chemistry* / Q000528:radiation effects; D013010:Sonication / Q000379:methods*
chemical_list: D000477:Alkylating Agents; D002712:Chlorides; D010880:Piperidines; D012822:Silicon Dioxide