title: Polyarteritis nodosa associated with essential mixed cryglobulinemia revealed by subarachnoid hemorrhage.
abstract: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis mediated by intravascular deposition of immune complexes. We report a 55-year-old man with PAN revealed by CNS vasculitis with subarachnoid hemorrhage and brainstem vasogenic oedema, associated with essential mixed cryoglobulinemia. In spite of aggressive treatment (steroids and cyclophosphamide), the patient became tetraplegic. A pathophysiological relationship between cryoglobulin and PAN can be suspected. Mixed cryoglobulinemia may trigger vasculitis with PAN features, possibly explaining the lack of treatment response.
authors: Department of Neurology, Nîmes University Medical Center, Caremeau Hospital, France. taiebguillaume@gmail.com
authors: Guillaume
authors: G
authors: Taieb
authors: Dimitri
authors: D
authors: Renard
authors: Mathieu
authors: M
authors: Briere
authors: Benjamin
authors: B
authors: Conte
authors: Pierre-Francois
authors: PF
authors: Perrigault
authors: Valerie
authors: V
authors: Rigau
authors: Alain
authors: A
authors: Bonafe
authors: Pierre
authors: P
authors: Labauge
mesh_terms: D003449:Cryoglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D003520:Cyclophosphamide