title: Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR.
abstract: Exercise-induced collapse (EIC) is an autosomal recessive disorder in Labrador retrievers. In this study, an allele-specific PCR was developed to detect the point mutation G767T in exon 6 of canine DNM1, previously shown to be responsible for canine EIC. Of 133 Labrador retrievers tested in Japan, 6 (4.5%) were homozygous (EIC) and 50 (37.6%) were heterozygous (carriers) for the G767T mutation.
authors: Nasunogahara Animal Clinic, 2-3574-98, Asaka, Ohtawara-shi, Tochigi 324-0043, Japan. mtakanosu@hotmail.com
authors: Masamine
authors: M
authors: Takanosu
authors: Hirokazu
authors: H
authors: Mori
authors: Hiroetsu
authors: H
authors: Suzuki
authors: Katsushi
authors: K
authors: Suzuki
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000503:physiopathology; D004285:Dogs; D034284:Dynamin I / Q000235:genetics*; D060005:Genotyping Techniques / Q000662:veterinary; D007564:Japan; D018908:Muscle Weakness / Q000235:genetics / Q000503:physiopathology / Q000662:veterinary*; D010375:Pedigree; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods* / Q000662:veterinary; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D034284:Dynamin I