title: Successful treatment of NDM-1 Klebsiella pneumoniae bacteraemia in a neutropenic patient.
abstract: The rapid emergence of novel multidrug-resistant organisms coupled with the slow development of new antibiotics is of great concern. With the discovery of New Delhi metallo-beta-lactamase 1 (NDM-1)-producing Klebsiella pneumoniae, clinicians are faced with problems in the treatment of infections caused by this multidrug-resistant organism. Therapeutic experiences are limited. We share our experience of the successful treatment of a febrile neutropenic patient with NDM-1-producing K. pneumoniae bacteraemia.
authors: Department of Infectious Diseases, Singapore General Hospital, Singapore. jaime.chien.m.f@singhealth.com.sg
authors: Jaime Mei Fong
authors: JM
authors: Chien
authors: Tse Hsien
authors: TH
authors: Koh
authors: Kian Sing
authors: KS
authors: Chan
authors: Thuan Heng Charles
authors: TH
authors: Chuah
authors: Thuan Tong
authors: TT
authors: Tan
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D009503:Neutropenia / Q000382:microbiology; D011112:Polymyxin B / Q000627:therapeutic use; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D011112:Polymyxin B