title: Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes.
abstract: 3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) is a successful iron chelator, which has been widely investigated for its activity in mitigating iron overload and in protecting against oxidative stress due to Reactive Oxygen Species (ROS). Herein, we present the synthesis, characterisation, physicochemical properties and antioxidant activity of two novel bioconjugates of β-cyclodextrin bearing the deferiprone moiety either on the upper rim (1) or on the lower rim (2) of the cyclodextrin and their iron(III) complexes. Protonation and iron stability constants were measured by spectrophotometric titration for the two systems and antioxidant activity studied for both the ligands and the iron(III) complexes.
authors: School of Science, University of Greenwich at Medway, Chatham, Kent, UK. a.puglisi@greenwich.ac.uk
authors: Antonino
authors: A
authors: Puglisi
authors: John
authors: J
authors: Spencer
authors: Valentina
authors: V
authors: Oliveri
authors: Graziella
authors: G
authors: Vecchio
authors: Xiaole
authors: X
authors: Kong
authors: James
authors: J
authors: Clarke
authors: John
authors: J
authors: Milton
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D000077543:Deferiprone; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D011522:Protons; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008024:Ligands; D009942:Organometallic Compounds; D011522:Protons; D011728:Pyridones; D047392:beta-Cyclodextrins; D000077543:Deferiprone; D007501:Iron; D013482:Superoxide Dismutase