title: Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.
abstract: Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.
authors: Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
authors: Youcai
authors: Y
authors: Hu
authors: John B
authors: JB
authors: MacMillan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D042301:Sphingomonadaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D052160:Benzothiazoles; C569990:erythrazole A; C569991:erythrazole B