title: Cytotoxic effects of polybasic acids, poly(alkenoic acid)s, and the monomers with various functional groups on human pulp fibroblasts.
abstract: This study evaluated the cytotoxicity of various polybasic acids, poly(alkenoic acid)s, and the monomers with various acidic functional groups such as carboxyl, phosphoryl, and sulfo group. The cell growth of fibroblasts cultivated in medium containing polybasic acids and polymers up to the concentration to 5 mmol/L was not significantly different compared with that of control without their acids. On the other hand, the cell growth fibroblasts cultivated in medium containing 1 mmol/L of the monomers with acryloyloxy and phosphoryl or carboxyl group decreased remarkably compared with that of the control and the cells were probably lifeless. Those exposed to the monomers with a ether bond and a carboxyl group or a amide bond and a sulfo group was not significantly different compared with that of control.
authors: Department of Biomaterials and Devices, Kanagawa Dental College.
authors: Shigeaki
authors: S
authors: Kurata
authors: Kumiko
authors: K
authors: Morishita
authors: Toshio
authors: T
authors: Kawase
authors: Kozo
authors: K
authors: Umemoto
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects*; D005899:Glass Ionomer Cements / Q000633:toxicity*; D006801:Humans; D008689:Methacrylates / Q000633:toxicity; D011076:Polycarboxylate Cement / Q000633:toxicity*; D011108:Polymers / Q000633:toxicity; D011109:Polymethacrylic Acids / Q000633:toxicity*; D019279:Resin Cements / Q000633:toxicity*
chemical_list: D005899:Glass Ionomer Cements; D008689:Methacrylates; D011076:Polycarboxylate Cement; D011108:Polymers; D011109:Polymethacrylic Acids; D019279:Resin Cements