title: Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo.
abstract: Signaling by the many ligands of the TGFβ family strongly converges towards only five receptor-activated, intracellular Smad proteins, which fall into two classes i.e. Smad2/3 and Smad1/5/8, respectively. These Smads bind to a surprisingly high number of Smad-interacting proteins (SIPs), many of which are transcription factors (TFs) that co-operate in Smad-controlled target gene transcription in a cell type and context specific manner. A combination of functional analyses in vivo as well as in cell cultures and biochemical studies has revealed the enormous versatility of the Smad proteins. Smads and their SIPs regulate diverse molecular and cellular processes and are also directly relevant to development and disease. In this survey, we selected appropriate examples on the BMP-Smads, with emphasis on Smad1 and Smad5, and on a number of SIPs, i.e. the CPSF subunit Smicl, Ttrap (Tdp2) and Sip1 (Zeb2, Zfhx1b) from our own research carried out in three different vertebrate models.
authors: Laboratory of Molecular Biology (Celgen) of Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. andrea.conidi@med.kuleuven.be
authors: Andrea
authors: A
authors: Conidi
authors: Silvia
authors: S
authors: Cazzola
authors: Karen
authors: K
authors: Beets
authors: Kathleen
authors: K
authors: Coddens
authors: Clara
authors: C
authors: Collart
authors: Frederique
authors: F
authors: Cornelis
authors: Luk
authors: L
authors: Cox
authors: Debruyn
authors: D
authors: Joke
authors: Mariya P
authors: MP
authors: Dobreva
authors: Ruben
authors: R
authors: Dries
authors: Camila
authors: C
authors: Esguerra
authors: Annick
authors: A
authors: Francis
authors: Abdelilah
authors: A
authors: Ibrahimi
authors: Roel
authors: R
authors: Kroes
authors: Flore
authors: F
authors: Lesage
authors: Elke
authors: E
authors: Maas
authors: Ivan
authors: I
authors: Moya
authors: Paulo N G
authors: PN
authors: Pereira
authors: Elke
authors: E
authors: Stappers
authors: Agata
authors: A
authors: Stryjewska
authors: Veronique
authors: V
authors: van den Berghe
authors: Liesbeth
authors: L
authors: Vermeire
authors: Griet
authors: G
authors: Verstappen
authors: Eve
authors: E
authors: Seuntjens
authors: Lieve
authors: L
authors: Umans
authors: An
authors: A
authors: Zwijsen
authors: Danny
authors: D
authors: Huylebroeck
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta