title: Neonatal monosodium glutamate administration increases aminooxyacetic acid (AOA) susceptibility effects in adult mice.
abstract: Neonatal administration of monosodium glutamate (MSG) to mice causes neurotoxicity of the CNS resulting in endocrine, metabolic and behavioral abnormalities. Aminooxyacetic acid (AOAA) is a potent inhibitor of GABA-transaminase and increases GABA levels in the brain. In this work, we studied the effect of neonatal treatment of CFW mice with MSG (2 mg/g sc on the 2nd and 4th days after birth followed by 4 mg/g on days 6, 8 and 10) on AOAA- (100 to 250 mg/kg ip) induced hypothermia, hypnosis and lethality after six months of treatment. The control group was vehicle-treated only. MSG treatment significantly increased susceptibility to the hypothermic, hypnotic and lethal effect of AOAA acutely administered. The increased susceptibility to the depressor effects of AOAA may occur as a consequence of changes in neural excitability, up regulation of GABA-receptors or might be related to pharmacokinetic modifications induced by neonatal treatment with MSG.
authors: Department of Pharmacology, Faculty of Medicine, National University of Mexico, México, D.F., México. casam@servidor.unam.mx
authors: Alfonso Efraín
authors: AE
authors: Campos-Sepúlveda
authors: Maria Elena
authors: ME
authors: Martínez Enríquez
authors: Raúl
authors: R
authors: Rodríguez Arellanes
authors: Luz Elena
authors: LE
authors: Peláez
authors: Alyn Lizeth
authors: AL
authors: Rodríguez Amézquita
authors: Alyne
authors: A
authors: Cadena Razo
mesh_terms: D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005260:Female; D018682:GABA Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects*; D012970:Sodium Glutamate / Q000633:toxicity*
chemical_list: D018682:GABA Agents; D000625:Aminooxyacetic Acid; D012970:Sodium Glutamate