title: Combination effects of digalloylresveratrol with arabinofuranosylcytosine and difluorodeoxycytidine in human leukemia and pancreatic cancer cells.
abstract: Digalloylresveratrol (DIG) is a newly synthesized agent aimed to combine the biological effects of the natural compounds, gallic acid and resveratrol, which both are free radical scavengers exhibiting anticancer activity. In this study, we investigated the effects of DIG on the growth of human HL-60 leukemia cells and on the colony formation of human BxPC-3 and PANC-1 pancreatic cancer cells. DIG was applied alone and in combination with arabinofuranosylcytosine (Ara-C) or difluorodeoxycytidine (dFdC), depending on the cell line employed. All IC(50) values observed were in the low micromolar range rendering DIG a promising antitumor compound in vitro. Considering the combination experiments, DIG yielded additive effects with Ara-C in HL-60 cells and-to a lesser extent-with dFdC in BxPC-3 and PANC-1 cells. Owing to our results, DIG may be further investigated in vitro and in animals.
authors: Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria.
authors: Philipp
authors: P
authors: Saiko
authors: Geraldine
authors: G
authors: Graser
authors: Sibylle
authors: S
authors: Madlener
authors: Simone
authors: S
authors: Schwarz
authors: Georg
authors: G
authors: Krupitza
authors: Walter
authors: W
authors: Jaeger
authors: Venkateswarlu
authors: V
authors: Somepalli
authors: Trimurtulu
authors: T
authors: Golakoti
authors: Monika
authors: M
authors: Fritzer-Szekeres
authors: Thomas
authors: T
authors: Szekeres
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D003561:Cytarabine / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014410:Tumor Stem Cell Assay; D000093542:Gemcitabine
chemical_list: D013267:Stilbenes; C534866:digalloylresveratrol; D003561:Cytarabine; D003841:Deoxycytidine; D005707:Gallic Acid; D000093542:Gemcitabine