title: Role of apoptosis in adverse ventricular remodeling.
abstract: Apoptosis is a key feature in the progression of heart disease. Stage B heart failure is characterized by a structurally abnormal heart in which the remodeled myocardium is prone to apoptosis. Elimination of the proapoptotic stimuli or inhibition of the apoptotic cascade could presumably rescue the myocardium and halt the progression of adverse remodeling and heart failure. In this article, the authors review the role of apoptosis (or programmed cell death) in determining the evolution of symptomatic heart failure and particularly the adverse remodeling in the aftermath of acute myocardial infarction.
authors: VCU Pauley Heart Center, Virginia Commonwealth University, VCU Medical Center, 1200 East Broad Street, Richmond, VA 23298, USA. abbatea@yahoo.com
authors: Antonio
authors: A
authors: Abbate
authors: Jagat
authors: J
authors: Narula
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018450:Disease Progression; D006333:Heart Failure / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D020257:Ventricular Remodeling / Q000502:physiology*