title: Is the myonuclear domain size fixed?
abstract: It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely related with the oxidative capacity of a fibre. Overall, the observations of an increase in myonuclear domain size during both maturational growth and overload-induced hypertrophy, and the decrease in myonuclear domain size during disuse- and ageing-associated muscle atrophy suggest that the concept of a constant myonuclear domain size needs to be treated cautiously. It also suggests that only when the myonuclear domain size exceeds a certain threshold during growth or overload-induced hypertrophy acquisition of new myonuclei is required for further fibre hypertrophy.
authors: Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Chester Street,  Manchester M1 5GD, United Kingdom.
authors: S F T
authors: SF
authors: Van der Meer
authors: R T
authors: RT
authors: Jaspers
authors: H
authors: H
authors: Degens
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology* / Q000648:ultrastructure*