title: Larrealignans A and B, novel lignan glycosides from the aerial parts of Larrea tridentata.
abstract: Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds (1-3) and aglycones (1a, 2a) of 1 and 2 were evaluated for their cytotoxic activities against HL-60 human leukemia cells.
authors: Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan. yokosuka@toyaku.ac.jp
authors: Akihito
authors: A
authors: Yokosuka
authors: Yukiko
authors: Y
authors: Matsuo
authors: Maki
authors: M
authors: Jitsuno
authors: Kohei
authors: K
authors: Adachi
authors: Yoshihiro
authors: Y
authors: Mimaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D032442:Larrea / Q000737:chemistry*; D007938:Leukemia / Q000188:drug therapy; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans