title: Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels.
abstract: Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms.
authors: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors: Diana
authors: D
authors: Kadetoff
authors: Jon
authors: J
authors: Lampa
authors: Marie
authors: M
authors: Westman
authors: Magnus
authors: M
authors: Andersson
authors: Eva
authors: E
authors: Kosek
mesh_terms: D000328:Adult; D005260:Female; D005356:Fibromyalgia / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood / Q000134:cerebrospinal fluid* / Q000502:physiology*; D053583:Interleukin-1beta / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid*; D008875:Middle Aged
chemical_list: D018836:Inflammation Mediators; D053583:Interleukin-1beta; D016209:Interleukin-8