title: Epigenetic signatures in stem cells and cancer stem cells.
abstract: The physiological properties of pluripotency in stem cells and the processes of cell specialization are governed by epigenetic mechanisms, as they are inheritable but not dependent on the cell genotype. There is cumulating evidence demonstrating the presence of cells with stem cell properties within tumors, suggesting that these cells are responsible for tumor growth and heterogeneity. As epigenetic control of self-renewal and pluripotency is a hallmark of stem cells, there is increased interest in studying similar epigenetic mechanisms governing these stemness properties in cancer stem cells. Here we will review the evidence supporting a role for epigenetic mechanisms in the induction of cancer stem cells, with an emphasis on the epigenetic regulatory networks involved in the establishment of normal self-renewal and pluripotency, and their potential deregulation in cancer. We will also discuss the data supporting the plasticity of these mechanisms and its potential therapeutic implications.
authors: Epigenetics Group, International Agency for Research on Cancer, 150 cours Albert-Thomas, Lyon cedex 08, France.
authors: Hector
authors: H
authors: Hernandez-Vargas
authors: Nino
authors: N
authors: Sincic
authors: Maria
authors: M
authors: Ouzounova
authors: Zdenko
authors: Z
authors: Herceg
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology*; D004622:Embryo, Mammalian / Q000378:metabolism / Q000503:physiopathology*; D054278:Embryonal Carcinoma Stem Cells / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000502:physiology; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000378:metabolism / Q000502:physiology*
chemical_list: D002843:Chromatin; D006657:Histones; D035683:MicroRNAs