title: Clot retraction.
abstract: The study of clot retraction in vitro has been adopted as a simple and reproducible approach to assess platelet function. Plasma clots should retract away from the sides of a glass tube within a few hours allowing the rapid characterization of outside-in signaling through platelet integrin α(IIb)β(3). In this chapter, we describe the role of platelets in fibrin clot retraction and provide a detailed description of the methods used to assess this process.
authors: Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, The University of Reading, Reading, UK. k.l.tucker@reading.ac.uk
authors: Katherine L
authors: KL
authors: Tucker
authors: Tanya
authors: T
authors: Sage
authors: Jonathan M
authors: JM
authors: Gibbins
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D001792:Blood Platelets / Q000378:metabolism; D003018:Clot Retraction; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D051379:Mice
chemical_list: D005337:Fibrin