title: Lignans from the heartwood of Streblus asper and their inhibiting activities to hepatitis B virus.
abstract: Three new lignans, erythro-strebluslignanol (1), threo-7'-methoxyl strebluslignanol (2) and erythro-7'-methoxyl strebluslignanol (3), together with twelve known compounds were isolated from the n-butanol and chloroform fractions of the heartwood of Streblus asper. Their structures were elucidated through extensive spectroscopic methods, including MS and 2D NMR experiments (HMQC and HMBC). The stereochemistry at the chiral center was determined using CD spectra, as well as analysis of coupling constants and optical rotation data, respectively. Primary bioassays showed that 6-hydroxyl-7-methoxyl-coumarin (5) and ursolic acid (10) showed anti-HBV activities, with IC(50) values of 29.60 μM and 89.91 μM for HBsAg at no cytotoxicity, and IC(50) values of 46.41 μM and 97.61 μM for HBeAg at no cytotoxicity, respectively.
authors: Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China), School of Environment and Resource of Guangxi Normal University, Guilin, PR China.
authors: Lu-Qing
authors: LQ
authors: Li
authors: Jun
authors: J
authors: Li
authors: Yan
authors: Y
authors: Huang
authors: Qiang
authors: Q
authors: Wu
authors: Sheng-Ping
authors: SP
authors: Deng
authors: Xiao-Jian
authors: XJ
authors: Su
authors: Rui-Yun
authors: RY
authors: Yang
authors: Ji-Guo
authors: JG
authors: Huang
authors: Zi-Zhan
authors: ZZ
authors: Chen
authors: Shan
authors: S
authors: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006514:Hepatitis B Surface Antigens / Q000187:drug effects; D006513:Hepatitis B e Antigens / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029586:Moraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014934:Wood / Q000737:chemistry; D000097245:Ursolic Acid
chemical_list: D000998:Antiviral Agents; D001713:Biphenyl Compounds; D003374:Coumarins; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017705:Lignans; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid; C579549:5-allyl-5'-(1,2-dihydroxypropyl) (1,1'-biphenyl)-2,2'-diol; C579550:5-allyl-5'-(2-hydroxy-1-methoxypropyl) (1,1-biphenyl)-2,2'-diol; C030123:coumarin