title: Synthesis enables a structural revision of the Mycobacterium tuberculosis-produced diterpene, edaxadiene.
abstract: A stereodivergent synthesis of the [3.3.1] bicyclic core of edaxadiene was completed utilizing a key intramolecular oxidative ketone allylation. Significant discrepancies between the spectroscopic data obtained for the synthetic construct and the natural isolate raised questions about the structural assignment of edaxadiene. A subsequent structural reassignment was validated by completion of a total synthesis of the correct structure of the natural product.
authors: Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ, 08544, USA.
authors: Jillian E
authors: JE
authors: Spangler
authors: Cheryl A
authors: CA
authors: Carson
authors: Erik J
authors: EJ
authors: Sorensen