title: Renal resistive index in 55 dogs with degenerative mitral valve disease.
abstract: BACKGROUND
  Azotemia occurs frequently in dogs with degenerative mitral valve disease (DMVD). It could indicate changes in renal hemodynamics.
  
  
  OBJECTIVE
  To assess the renal resistive index (RI) in dogs with DMVD, and the statistical link between heart failure class, azotemia, echo-Doppler parameters, several plasma variables, and RI.
  
  
  METHODS
  Fifty-five dogs with naturally occurring DVMD were used (ISACHC class 1 [n = 28], 2 [n = 19], and 3 [n = 8]).
  
  
  METHODS
  Observational, blinded study, performed under standardized conditions. Physical examination, renal ultrasonography, and echo-Doppler examinations were performed in awake dogs. The RI of the renal, interlobar, and arcuate arteries were measured. Plasma creatinine, urea, and N-terminal pro-B-type natriuretic peptide concentrations (NT-proBNP) were determined. Statistical links between variables and RI were tested by means of a general linear model.
  
  
  RESULTS
  Although the RI of renal and arcuate arteries were unaffected by ISACHC class, the left interlobar RI increased (P < .001) from 0.62 ± 0.05 (mean ± SD) in class 1 to 0.76 ± 0.08 in class 3. It was also higher (P < .001) in azotemic (0.74 ± 0.08) than in non-azotemic (0.62 ± 0.05) dogs. Similar findings were observed for right interlobar RI. Univariate analysis showed a positive statistical link between NT-proBNP (P = .002), urea (P < .001), creatinine (P = .002), urea-to-creatinine ratio (P < .001), left atrium-to-aorta ratio (P < .001), regurgitation fraction (P < .001), systolic pulmonary arterial pressure (P < .001), shortening fraction (P = .035), and RI.
  
  
  CONCLUSIONS
  In dogs with DMVD, interlobar RI increases with heart failure severity and azotemia but a cause and effect relationship remains to be established.
authors: Centre Hospitalier Universitaire Vétérinaire d'Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
authors: V
authors: V
authors: Chetboul
authors: T
authors: T
authors: Daste
authors: V
authors: V
authors: Gouni
authors: D
authors: D
authors: Concordet
authors: E
authors: E
authors: Trehiou-Sechi
authors: F
authors: F
authors: Serres
authors: J L
authors: JL
authors: Pouchelon
authors: C A
authors: CA
authors: Germain
authors: C
authors: C
authors: Layssol-Lamour
authors: H P
authors: HP
authors: Lefebvre
mesh_terms: D000818:Animals; D053099:Azotemia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D012044:Regression Analysis; D014508:Urea / Q000097:blood
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014508:Urea; D003404:Creatinine