title: The antibody response to pandemic H1N1 2009 influenza vaccine in adult organ transplant patients.
abstract: Limited data are available regarding antibody response and the safety of the monovalent influenza A H1N1/09 vaccine for immunocompromised patients. In this study, the humoral response to this vaccine in solid organ transplant (SOT) recipients and healthy individuals was evaluated. Eighty-two SOT recipients and 28 healthy individuals received two doses of the influenza A H1N1/09 AS03 adjuvanted vaccine containing 3.75 mg of haemagglutinin at a 3- to 4-week interval. Serum samples were drawn at baseline and 3-4 weeks after the first and second vaccine doses. Seroprotective titres were measured with a haemagglutination inhibition. After the first dose seroprotective titres were observed in 69% of the SOT patients and in 96% of the healthy controls (P = 0.006), and increased after the second dose to 80% and 100%, respectively (P = 0.003). All controls and 77% of the SOT recipients achieved a ≥4-fold titre rise after the first immunisation (P = 0.005). The vaccine was well tolerated and no acute rejection was observed. Influenza A H1N1/09 vaccine elicited a protective antibody response in the majority of SOT recipients, but the response was lower when compared with controls. A second dose significantly improved vaccine immunogenicity in SOT recipients. (ClinicalTrials.gov number: NCT01254955).
authors: Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden. marie.felldin@surgery.gu.se
authors: Marie
authors: M
authors: Felldin
authors: Marie
authors: M
authors: Studahl
authors: Bo
authors: B
authors: Svennerholm
authors: Vanda
authors: V
authors: Friman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology; D008875:Middle Aged; D016377:Organ Transplantation; D058873:Pandemics; D013997:Time Factors; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines