title: Long-term survival of women with epithelial ovarian cancer detected by ultrasonographic screening.
abstract: OBJECTIVE
  To estimate the effect of ultrasonographic screening on stage at detection and long-term disease-specific survival of women with epithelial ovarian cancer.
  
  
  METHODS
  Eligibility included all asymptomatic women aged 50 years and older and women aged 25 years and older with a documented family history of ovarian cancer. From 1987 to 2011, 37,293 women received annual ultrasonographic screening. Women with abnormal screens underwent tumor morphology indexing, serum biomarker analysis, and surgery.
  
  
  RESULTS
  Forty-seven invasive epithelial ovarian cancers and 15 epithelial ovarian tumors of low malignant potential were detected. No women with low malignant potential tumors experienced recurrent disease. Stage distribution for invasive epithelial cancers was: stage I, 22 (47%); stage II, 11 (23%); stage III, 14 (30%), and stage IV, 0 (0%). Follow-up varied from 2 months to 20.1 years (mean, 5.8 years). The 5-year survival rate for invasive epithelial ovarian cancers detected by screening was: stage I, 95%±4.8%; stage II, 77.1%±14.5%; and stage III, 76.2%±12.1%. The 5-year survival rate for all women with invasive epithelial ovarian cancer detected by screening as well as interval cancers was 74.8%±6.6% compared with 53.7%±2.3% for unscreened women with ovarian cancer from the same institution treated by the same surgical and chemotherapeutic protocols (P<.001).
  
  
  CONCLUSIONS
  Annual ultrasonographic screening of asymptomatic women achieved increased detection of early-stage ovarian cancer cases and an increase in 5-year disease-specific survival rate for women with ovarian cancer.
  
  
  METHODS
  II.
authors: From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and the Department of Statistics, the University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, Kentucky.
authors: John Rensselaer
authors: JR
authors: van Nagell
authors: Rachel Ware
authors: RW
authors: Miller
authors: Christopher P
authors: CP
authors: DeSimone
authors: Frederick R
authors: FR
authors: Ueland
authors: Iwona
authors: I
authors: Podzielinski
authors: Scott T
authors: ST
authors: Goodrich
authors: Jeff W
authors: JW
authors: Elder
authors: Bin
authors: B
authors: Huang
authors: Richard J
authors: RJ
authors: Kryscio
authors: Edward John
authors: EJ
authors: Pavlik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007629:Kentucky / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D010053:Ovary / Q000473:pathology; D015996:Survival Rate; D014463:Ultrasonography