title: Uterine glomeruloid hemangioma in a patient without POEMS syndrome.
abstract: Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometrial vessels, a lobular, glomeruloid proliferation of capillary-like CD31 and vascular endothelial growth factor receptor-1-positive endothelial cells was found. The capillary loops were lined by endothelial cells, most of them containing PAS-positive and immunoglobulin-positive eosinophilic hyaline globules (thanatosomes). This vascular proliferation was consistent with a glomeruloid hemangioma. Although an extracutaneous glomeruloid vascular proliferation has been found in the retroperitoneal adipose tissue in a patient with POEMS syndrome, this study reports what seems to be the first case of visceral glomeruloid hemangioma in a patient without POEMS syndrome. The authors hypothesize that the glomeruloid endothelial cell proliferation with vascular endothelial growth factor receptor-1 expression may be a paraneoplastic phenomenon.
authors: University Clinic Hospital, University of Valencia, Valencia, Spain.
authors: Francisco
authors: F
authors: Giner
authors: Amparo
authors: A
authors: Compañ
authors: Carlos
authors: C
authors: Monteagudo
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006391:Hemangioma / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009378:Neoplasms, Multiple Primary; D016878:POEMS Syndrome; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor