title: Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study.
abstract: BACKGROUND
  Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder.
  
  
  METHODS
  Direct-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozygotic and dizygotic matched-control twin pairs with low ADHD symptom scores. Structural equation modelling was used to quantify the genetic and environmental contributions to the phenotypic covariance between ADHD and VLF activity.
  
  
  RESULTS
  Attention deficit hyperactivity disorder was significantly associated with reduced VLF power during cognitive activation, which suggests reduced synchronization of widespread neuronal activity. Very low-frequency power demonstrated modest heritability (0.31), and the genetic correlation (-0.80) indicated a substantial degree of overlap in genetic influences on ADHD and VLF activity.
  
  
  CONCLUSIONS
  Altered VLF activity is a potential candidate intermediate phenotype of ADHD, which warrants further investigation of underlying neurobiological and genetic mechanisms.
authors: MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK. charlotte.tye@kcl.ac.uk
authors: Charlotte
authors: C
authors: Tye
authors: Frühling
authors: F
authors: Rijsdijk
authors: Corina U
authors: CU
authors: Greven
authors: Jonna
authors: J
authors: Kuntsi
authors: Philip
authors: P
authors: Asherson
authors: Gráinne
authors: G
authors: McLoughlin
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics*; D004569:Electroencephalography; D058068:Endophenotypes; D004739:England / Q000453:epidemiology; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012044:Regression Analysis; D014852:Wales / Q000453:epidemiology