title: Recombinant human growth hormone replacement in a Japanese man with a novel PROP1 gene mutation (R112X).
abstract: Congenital combined pituitary hormone deficiency (CPHD) is associated with deficiencies of anterior pituitary hormones. PROP1 gene mutations are often responsible for CPHD, but few such cases have been reported in Japan. This study describes a 37-year-old Japanese man with CPHD, treated with hydrocortisone, testosterone, and L-thyroxine, who was evaluated for adult growth hormone deficiency (GHD). Gene analysis revealed a previously unknown PROP1 mutation (R112X). After 10 months of recombinant human growth hormone (rhGH) administration, cortisol and urinary free cortisol levels were significantly lower than before therapy. This case underscores the importance of reassessing hypothalamic-pituitary-adrenal axis function in GHD patients, especially those with a PROP1 mutation, during rhGH therapy.
authors: Department of Metabolism and Endocrinology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center. aogo@kyumed.jp
authors: Atsushi
authors: A
authors: Ogo
authors: Tetsushi
authors: T
authors: Maruta
authors: Chiharu
authors: C
authors: Ide
authors: Yoshiyuki
authors: Y
authors: Sakai
authors: Yuka
authors: Y
authors: Matoba
authors: Shinsuke
authors: S
authors: Hiramatsu
authors: Takeshi
authors: T
authors: Usui
authors: Mitsuhide
authors: M
authors: Naruse
authors: Akira
authors: A
authors: Shimatsu
mesh_terms: D000328:Adult; D013006:Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008297:Male; D009154:Mutation; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D018398:Homeodomain Proteins; C102134:Prophet of Pit-1 protein; D011994:Recombinant Proteins; D013006:Growth Hormone; D006854:Hydrocortisone