title: Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes.
abstract: BACKGROUND
  Single-walled carbon nanotubes (SWNT) are poorly soluble in water, so their applications are limited. Therefore, aqueous solutions of SWNT, designed by noncovalent functionalization and without toxicity, are required for biomedical applications.
  
  
  METHODS
  In this study, we conjugated docetaxel with SWNT via π-π accumulation and used a surfactant to functionalize SWNT noncovalently. The SWNT were then conjugated with docetaxel (DTX-SWNT) and linked with NGR (Asn-Gly-Arg) peptide, which targets tumor angiogenesis, to obtain a water-soluble and tumor-targeting SWNT-NGR-DTX drug delivery system.
  
  
  RESULTS
  SWNT-NGR-DTX showed higher efficacy than docetaxel in suppressing tumor growth in a cultured PC3 cell line in vitro and in a murine S180 cancer model. Tumor volumes in the S180 mouse model decreased considerably under near-infrared radiation compared with the control group.
  
  
  CONCLUSIONS
  The SWNT-NGR-DTX drug delivery system may be promising for high treatment efficacy with minimal side effects in future cancer therapy.
authors: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors: Lei
authors: L
authors: Wang
authors: Mingyue
authors: M
authors: Zhang
authors: Nan
authors: N
authors: Zhang
authors: Jinjin
authors: J
authors: Shi
authors: Hongling
authors: H
authors: Zhang
authors: Min
authors: M
authors: Li
authors: Chao
authors: C
authors: Lu
authors: Zhenzhong
authors: Z
authors: Zhang
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009842:Oligopeptides / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D043823:Taxoids / Q000493:pharmacokinetics / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; C526428:NGR peptide; D037742:Nanotubes, Carbon; D009842:Oligopeptides; D013501:Surface-Active Agents; D043823:Taxoids; D000077143:Docetaxel