title: Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
abstract: Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.
authors: Natural Product Microbes Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180 001, India.
authors: Ajay
authors: A
authors: Kumar
authors: Bhahwal A
authors: BA
authors: Shah
authors: Samar
authors: S
authors: Singh
authors: Abid
authors: A
authors: Hamid
authors: Shashank K
authors: SK
authors: Singh
authors: Vijay K
authors: VK
authors: Sethi
authors: Ajit K
authors: AK
authors: Saxena
authors: Jaswant
authors: J
authors: Singh
authors: Subhash C
authors: SC
authors: Taneja
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005434:Flow Cytometry / Q000379:methods; D018922:HL-60 Cells; D006801:Humans; D008956:Models, Chemical; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation; D050791:STAT Transcription Factors / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D050791:STAT Transcription Factors; D014315:Triterpenes; C054625:boswellic acid