title: What are the important factors in health-related quality of life for people with aphasia? A systematic review.
abstract: OBJECTIVE
  To determine factors associated with or predictive of poor health-related quality of life (HRQL) in people with aphasia poststroke. Better understanding of these factors can allow better targeting of rehabilitation programs.
  
  
  METHODS
  Electronic databases, covering medical (eg, Medline, Excerpta Medica Database, Evidence-Based Medicine Reviews, Cumulative Index to Nursing and Allied Health Literature, Ovid, Allied and Complementary Medicine Database) and social sciences (eg, PsycINFO) were searched and key experts were approached.
  
  
  METHODS
  Studies including specific information on the HRQL of people with aphasia poststroke using validated HRQL measures or established ways of analyzing qualitative data were included. Two reviewers independently screened studies against the eligibility criteria.
  
  
  METHODS
  This was undertaken independently by 2 reviewers. Discrepancies were resolved by consensus. Quantitative studies were assessed for quality with Counsell and Dennis' critical appraisal tool for systematic review of prognostic models in acute stroke; qualitative studies with the Critical Appraisal Skills Program tool for qualitative research.
  
  
  RESULTS
  Fourteen research reports met the eligibility criteria. Because of their high heterogeneity, the data synthesis was narrative. The evidence is not strong enough to determine the main predictors of HRQL in people with aphasia. Still, emotional distress/depression, severity of aphasia and communication disability, other medical problems, activity limitations, and aspects of social network and support were important factors.
  
  
  CONCLUSIONS
  Emotional distress, aphasia severity, communication and activity limitations, other medical problems, and social factors affect HRQL. Stroke HRQL studies need to include people with aphasia and report separately on them, in order to determine the main predictors of their HRQL and to identify what interventions can best address them.
authors: Department of Language, City University London, London, UK. k.hilari@city.ac.uk
authors: Katerina
authors: K
authors: Hilari
authors: Justin J
authors: JJ
authors: Needle
authors: Kirsty L
authors: KL
authors: Harrison
mesh_terms: D001037:Aphasia / Q000209:etiology* / Q000523:psychology*; D003142:Communication; D006304:Health Status; D006801:Humans; D011788:Quality of Life; D012720:Severity of Illness Index; D012944:Social Support; D013315:Stress, Psychological / Q000150:complications; D020521:Stroke / Q000150:complications* / Q000523:psychology*