title: [Lipid profile modifications in post-menopausal women treated with testosterone gel].
abstract: OBJECTIVE
  To assess lipid profile changes in post-menopausal women treated with testosterone gel.
  
  
  METHODS
  Thirty-six oophorectomized women on estradiol treatment who received transdermal testosterone gel (5mg daily) were enrolled into our study. Cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density-lipoprotein cholesterol (VLDL-C), and lipoprotein (a) were tested before and after 6 months of treatment.
  
  
  RESULTS
  Selected participants had a mean age of 50.9±4.6 years and a body mass index of 30.1±3.8 kg/m(2). Significantly decreased cholesterol levels were found after 6 months of treatment (204.5±35.1 mg/dL before treatment as compared to 183.1±21.9 mg/dL after treatment; p<0.05). A significant reduction was also seen in LDL-C levels after 6 months of treatment with testosterone gel as compared to baseline (130.9±29.7 mg/dL versus 118.5±21.3 mg/dL; p<0.05). No differences were found in triglyceride, HDL-C, VLDL-C, and lipoprotein (a) levels (p=ns).
  
  
  CONCLUSIONS
  El gel de testosterona, asociado a tratamiento estrogénico en mujeres ooforectomizadas, produce disminución de las concentraciones de colesterol y LDL-C posterior a 6 meses de tratamiento, sin afectar las concentraciones de triglicéridos, HDL-C, VLDL-C y lipoproteína (a)Testosterone gel, associated to estrogen treatment in oophorectomized women, decreased cholesterol and LDL-C levels after 6 months of treatment, without affecting serum triglyceride, HDL-C, VLDL-C, and lipoprotein (a) levels.
authors: Servicio de Medicina Interna, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
authors: Johanna
authors: J
authors: Fernández-Carvajal
authors: Hedy
authors: H
authors: Luz-Araujo
authors: Mery
authors: M
authors: Guerra-Velázquez
authors: Eduardo
authors: E
authors: Reyna-Villasmil
authors: Joel
authors: J
authors: Santos-Bolívar
authors: Duly
authors: D
authors: Torres-Cepeda
authors: Jorly
authors: J
authors: Mejia-Montilla
authors: Nadia
authors: N
authors: Reyna-Villasmil
mesh_terms: D000279:Administration, Cutaneous; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D005782:Gels; D006801:Humans; D007044:Hysterectomy; D008050:Lipid A / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood*; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D005782:Gels; D008050:Lipid A; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol; D002784:Cholesterol