title: Research and discovery of the first human cancer virus, HTLV-1.
abstract: Human T-cell lymphoma virus (HTLV)-1 was the first human retrovirus to be discovered. It has been recognized as the cause of adult T-cell leukemia (ATL). In addition to giving a historical perspective on HTLV-1 and other retrovirus research, this paper discusses the origin of HTLV-1; the modes of transmission and global epidemiology of HTLV-1 infection; the genome of HTLV-1 and the mechanism of HTLV-1-induced leukemogenesis; the role of HTLV-1 in other diseases, and recent breakthroughs in ATL therapy.
authors: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. rgallo@ihv.umaryland.edu
authors: Robert C
authors: RC
authors: Gallo
mesh_terms: D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001151:Arsenic / Q000008:administration & dosage / Q000627:therapeutic use; D049109:Cell Proliferation; D002472:Cell Transformation, Viral / Q000235:genetics*; D015490:HTLV-I Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D015215:Zidovudine; D007372:Interferons; D001151:Arsenic