title: Diketopiperazines produced by the halophilic archaeon, Haloterrigena hispanica, activate AHL bioreporters.
abstract: The generic term "quorum sensing" has been adopted to describe the bacterial cell-to-cell communication mechanism which coordinates gene expression when the population has reached a high cell density. Quorum sensing depends on the synthesis of small molecules that diffuse in and out of bacterial cells. There are few reports about this mechanism in Archaea. We report the isolation and chemical characterization of small molecules belonging to class of diketopiperazines (DKPs) in Haloterrigena hispanica, an extremely halophilic archaeon. One of the DKPs isolated, the compound cyclo-(L-prolyl-L-valine) activated N-acyl homoserine lactone (AHL) bioreporters, indicating that Archaea may have the ability to interact with AHL-producing bacteria within mixed communities.
authors: Institute of Biomolecular Chemistry, CNR-National Research Council of Italy, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy. gtommonaro@icb.cnr.it
authors: Giuseppina
authors: G
authors: Tommonaro
authors: Gennaro Roberto
authors: GR
authors: Abbamondi
authors: Carmine
authors: C
authors: Iodice
authors: Karen
authors: K
authors: Tait
authors: Salvatore
authors: S
authors: De Rosa
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism*; D054659:Diketopiperazines / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D017930:Genes, Reporter; D006216:Halobacteriaceae / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D015398:Signal Transduction; D012965:Sodium Chloride / Q000378:metabolism*
chemical_list: D054742:Acyl-Butyrolactones; D054659:Diketopiperazines; D012965:Sodium Chloride