title: Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia.
abstract: Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.
authors: Grupo de Gastrohepatologia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors: Maria-Cristina
authors: MC
authors: Navas
authors: Iris
authors: I
authors: Suarez
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authors: A
authors: Carreño
authors: Diego
authors: D
authors: Uribe
authors: Wilson Alfredo
authors: WA
authors: Rios
authors: Fabian
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authors: Cortes-Mancera
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authors: Martel
authors: Beatriz
authors: B
authors: Vieco
authors: Diana
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authors: Lozano
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authors: Jimenez
authors: Doriane
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authors: Gouas
authors: German
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authors: Osorio
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authors: Hoyos
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authors: Restrepo
authors: Gonzalo
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authors: Correa
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authors: Jaramillo
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authors: Lopez
authors: Luis Eduardo
authors: LE
authors: Bravo
authors: Maria Patricia
authors: MP
authors: Arbelaez
authors: Jean-Yves
authors: JY
authors: Scoazec
authors: Behnoush
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authors: Abedi-Ardekani
authors: Regina M
authors: RM
authors: Santella
authors: Isabelle
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authors: Chemin
authors: Pierre
authors: P
authors: Hainaut