title: The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity.
abstract: Spirulina platensis is a microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-carcinogenic properties. We investigated the mechanism of cisplatin induced hepatotoxicity and whether this natural antioxidant provided protection against cisplatin hepatotoxicity. The study was carried out in a mice model where the animals were segregated into different groups according to their treatments, e.g. control group with no treatment, cisplatin treated, cisplatin + Spirulina treated, cisplatin + vitamin C treated and cisplatin + Spirulina + vitamin C treated. The liver marker enzymes were found to be elevated following cisplatin treatment, signifying hepatotoxicity. The supplementation of Spirulina and vitamin C could effectively bring down the levels of these enzymes. Light microscopy also showed that cisplatin treatment induced liver injury and that histopathological abnormalities were prevented by Spirulina and vitamin C supplementation. This protective effect was further substantiated by the estimation of antioxidant levels and extent of lipid peroxidation in the Spirulina, vitamin C and Spirulina + vitamin C supplemented groups as compared to cisplatin alone.
authors: Department of Biophysics, PGIMER, Chandigarh, India. shalmoli2007@yahoo.co.in
authors: Shalmoli
authors: S
authors: Bhattacharyya
authors: Pooja
authors: P
authors: Mehta
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002945:Cisplatin / Q000633:toxicity*; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D053545:Spirulina / Q000737:chemistry*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001205:Ascorbic Acid; D002945:Cisplatin