title: Can cytosine, thymine and uracil be formed in interstellar regions? A theoretical study.
abstract: This theoretical study investigates possible synthetic routes to cytosine, uracil and thymine in the gas phase from precursor molecules that have been detected in interstellar media. Studies at the CCSD(T)/6-311++G(d,p)//B3LYP/6-311++G(d,p) level of theory suggest that: The reactions between :CCCNH and :CCCO with monosolvated urea may constitute viable interstellar syntheses of cytosine and uracil. No low energy equilibration between cytosine and uracil has been demonstrated. The interaction of :CH(2) with the 5 C-H bond of uracil may form thymine in an energetically favourable reaction, but competing reactions where :CH(2) reacts with double bonds and other CH and NH bonds of uracil, reduce the effectiveness of this synthesis. The reaction between the hydrated propional enolate anion and isocyanic acid may produce thymine, in a reaction sequence where ΔG(reaction)(298 K) is -22 kJ mol(-1) and the maximum energy requirement (barrier to the first transition state) is only 47 kJ mol(-1).
authors: Department of Chemistry, The University of Adelaide, South Australia 5005, Australia.
authors: Tianfang
authors: T
authors: Wang
authors: John H
authors: JH
authors: Bowie
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000737:chemistry; D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D003596:Cytosine / Q000737:chemistry*; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry; D013696:Temperature; D013941:Thymine / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
chemical_list: D009570:Nitriles; C513097:cyanoacetylene; D014498:Uracil; C000522:cyanoacetaldehyde; D003596:Cytosine; D014508:Urea; D000079:Acetaldehyde; D000114:Acetylene; D013941:Thymine