title: [Prospect of using magnetic nanoparticles for potentiating the anticarcinogenic action of dinitrosyl iron complexes with thiol-containing ligands].
abstract: Low-molecular dinitrosyl iron complexes with thiol-containing ligands (cysteine or glutathione) were recently demonstrated to be capable of apoptosis modulation. Being in the intact (undecomposed) state, the complexes protect against the apoptosis, and when decomposed, they exhibit the proapoptotic activity. The possibility of the delivery of the complexes by ferromagnetic nanoparticles to carcinogenic tissues is considered using the external magnetic field for nanoparticle accumulation in these tissues.
authors: A F
authors: AF
authors: Vanin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003545:Cysteine / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D019169:Jurkat Cells; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D009589:Nitrogen Oxides / Q000378:metabolism / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects; D051381:Rats; D012867:Skin / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D058185:Magnetite Nanoparticles; D009589:Nitrogen Oxides; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione; D003545:Cysteine