title: Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6')-Ib-cr gene.
abstract: Two closely related Enterobacter aerogenes isolates presented a new identical aac(6')-Ib-cr genetic environment, including IS26. One isolate showed lower MICs of ciprofloxacin, norfloxacin, tobramycin, and amikacin and decreased expression of aac(6')-Ib-cr, which might be related to a 12-bp deletion causing a displacement of the -10 box upstream of the aac(6')-Ib-cr gene.
authors: Universidad La Rioja, Logroño, Spain.
authors: Elena
authors: E
authors: Ruiz
authors: Alain A
authors: AA
authors: Ocampo-Sosa
authors: Julia
authors: J
authors: Alcoba-Flórez
authors: Elena
authors: E
authors: Román
authors: Guillaume
authors: G
authors: Arlet
authors: Carmen
authors: C
authors: Torres
authors: Luis
authors: L
authors: Martínez-Martínez
mesh_terms: D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D021902:Enterobacter aerogenes / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D000123:Acetyltransferases; C056532:aminoglycoside N(6')-acetyltransferase