title: EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma.
abstract: miRNAs (microRNAs) are a class of non-coding small RNAs. The Epstein-Barr-virus (EBV) encoded miR-BHRF1-1 is barely expressed in most nasopharyngeal carcinoma (NPC) cells with EBV latent infection. Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle. The data further suggested that the miR-BHRF1-1-potentiated induction of EBV lytic replication was accompanied by inhibiting p53 expression. Our results demonstrated that the EBV original pathogen miR-BHRF1-1 is involved in the control of EBV late lytic replication by directly targeting the host p53 gene.
authors: Key Laboratory of Ministry of Education, Key Laboratory of Ministry of Health, Cancer Research Institute, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China.
authors: Zijian
authors: Z
authors: Li
authors: Xue
authors: X
authors: Chen
authors: Lili
authors: L
authors: Li
authors: Sufang
authors: S
authors: Liu
authors: Lifang
authors: L
authors: Yang
authors: Xiaoqian
authors: X
authors: Ma
authors: Min
authors: M
authors: Tang
authors: Ann M
authors: AM
authors: Bode
authors: Zigang
authors: Z
authors: Dong
authors: Lunquan
authors: L
authors: Sun
authors: Ya
authors: Y
authors: Cao
mesh_terms: D002277:Carcinoma; D002460:Cell Line; D015536:Down-Regulation; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
chemical_list: D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins