title: Two new terpenoids from endophytic fungus Periconia sp. F-31.
abstract: Two new terpenoids, (+)-(3S,6S,7R,8S)-periconone A (1) and (-)-(1R,4R,6S,7S)-2-caren-4,8-olide (2), have been isolated from an endophytic fungus Periconia sp., which was collected from the plant Annona muricata. Their structures were elucidated on the basis of extensive spectroscopic analyses. In the in vitro assays, the two compounds showed low cytotoxic activities against six human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, A2780 and MCF-7) with IC(50)>10(-5) M.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products, Ministry of Health, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P. R. China.
authors: Han-Lin
authors: HL
authors: Ge
authors: De-Wu
authors: DW
authors: Zhang
authors: Li
authors: L
authors: Li
authors: Dan
authors: D
authors: Xie
authors: Jian-Hua
authors: JH
authors: Zou
authors: Yi-Kang
authors: YK
authors: Si
authors: Jungui
authors: J
authors: Dai
mesh_terms: D031041:Annona / Q000382:microbiology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D013729:Terpenes; C484833:periconicin A