title: Animal models of maternal nutrition and altered offspring bone structure--bone development across the lifecourse.
abstract: It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the their in utero environment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother's nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation.
authors: Bone and Joint Research Group, Human Development and Health, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK. sal3@ soton.ac.uk
authors: Stuart A
authors: SA
authors: Lanham
authors: Caroline
authors: C
authors: Bertram
authors: Cyrus
authors: C
authors: Cooper
authors: Richard O C
authors: RO
authors: Oreffo
mesh_terms: D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology; D004032:Diet / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D047109:Fetal Development; D048070:Fetal Nutrition Disorders; D006801:Humans; D009751:Nutritional Requirements; D010024:Osteoporosis / Q000209:etiology*; D011247:Pregnancy