title: [Sickle cell disease: from molecular aspects to clinical practice. A case report and a literature analysis].
abstract: Sickle cell disease is the genetic disease most frequently detected at birth in France. The comprehension and knowledge of its pathophysiology allow to establish the principles of management for the drepanocytic patient, especially in the perioperative phase. In the light of recent recommendations published for anesthesia of a drepanocytic adult, this clinical case revealed allows to reexamine that subject, with a focus on biological aspects, which are transfusional strategy and antibioprophylaxy. The presented observation is a concrete feature of daily collaboration between clinician and biologist, which is an essential point of the ISO standard EN 15189 concerning laboratories' accreditation.
authors: Fédération d'anesthésie-réanimation et des urgences. sophiehuynh@gmail.com
authors: Sophie
authors: S
authors: Huynh-Moynot
authors: Jean-Clair
authors: JC
authors: Moynot
authors: Diane
authors: D
authors: Commandeur
authors: Marc
authors: M
authors: Danguy Des Deserts
authors: Etienne
authors: E
authors: Montelescaut
authors: Nadia
authors: N
authors: Kenane
authors: Isabelle
authors: I
authors: Drouillard
mesh_terms: D000755:Anemia, Sickle Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D001291:Attitude of Health Personnel; D003585:Cell Biology; D005260:Female; D006801:Humans; D008954:Models, Biological; D010820:Physicians; D011364:Professional Practice; D055815:Young Adult