title: [Expression and clinical significance of FOX04 in colorectal cancer].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of FOXO4 in colorectal cancer tissues.
  
  
  METHODS
  Immunohistochemistry assay was performed to detect the FOXO4 expression in 80 colorectal cancer and matched noncancerous tissues (18 cases in stage I, 32 in stage II, 24 in stage III and 6 in stage IV). The relationship between FOXO4 expression and the patients' clinicopathologic features including gender, differentiation and TNM staging was also analyzed.
  
  
  RESULTS
  The positive expression rate of FOXO4 protein in colorectal cancer tissues was 47.50%, which was significantly lower than that in matched noncancerous tissues (91.25%, P<O. 01). Statistical analysis showed that the expression of FOXO4 in colorectal cancer tissues were not obviously correlated with the patients' age, gender , tumor sizes and depth( P >0.05) . however, there were significant differences of FOXO4 expression in tumor differentiation, TNM stage and lymph node metastasis (P<0.05).
  
  
  CONCLUSIONS
  The expression of FOXO4 was significantly decreased or deleted in colorectal cancer, indicating that FOXO4 may function as a tumor suppressor in the development and progression of colorectal cancer.
authors: Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
authors: Liu
authors: L
authors: Xiang-qiang
authors: Tang
authors: T
authors: Shan-hong
authors: Zhang
authors: Z
authors: Zhi-yong
authors: Jin
authors: J
authors: Hai-feng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018797:Cell Cycle Proteins; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D051858:Forkhead Transcription Factors; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C108803:FOXO4 protein, human; D051858:Forkhead Transcription Factors; D014157:Transcription Factors