title: Childhood diarrhoea: failing conventional measures, what next?
abstract: BACKGROUND
  Diarrhoea is one of the leading causes of infant mortality. This article analyzes its contribution towards the realization of millennium development goal number 4 (MDG-4).
  
  
  METHODS
  A PubMed search using keywords acute infant diarrhea together with prevalence, management, or prevention 23 of the 634 generated articles were reviewed for inclusion.
  
  
  RESULTS
  WHO first expressed concern about diarrhoeal mortality in 1979. Two decades later it reported diarrhoea as the second leading cause of infant mortality worldwide. The annual death toll of 1.5 million is greater than AIDS, malaria and measles combined. Short term repercussions (dehydration, electrolyte imbalance, malnutrition, shock, death) plus long-term diminished fitness index, cognitive function, and school performance have major impact on society. Ever since its 1971 success, Oral Rehydration Therapy has been the cornerstone treatment of diarrhoea. Decreased compliance has been recorded worldwide with Kenya ranking first. Intravenous therapy is useful in preventing complications while anti-diarrhoeals and anti-microbials, are indicated in severe cases. Zinc supplementation has also proven effective, and is recommended along with rehydration. Furthermore, immunization and good hygiene prevent faecal-oral transmissions.
  
  
  CONCLUSIONS
  MDG-4 aims to reduce childhood mortality by 2/3 by 2015. Studies, however, show minimal progress, and the target is likely to be missed. Efforts must therefore be made to review existing strategies and formulate newer ones. Research priorities need to move away from perceived 'killer diseases' since far more children die in a day than have ever died from avian influenza for example.
authors: Department of Medical Physiology, University of Nairobi.
authors: Faraj
authors: F
authors: Alkizim
authors: Duncan
authors: D
authors: Matheka
authors: Anne
authors: A
authors: Muriithi
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D002648:Child; D046688:Child Mortality / Q000639:trends; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D003968:Diarrhea, Infantile / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D014943:Global Health / Q000639:trends; D006801:Humans; D007223:Infant; D007226:Infant Mortality / Q000639:trends*; D015995:Prevalence; D015532:Rehydration Solutions / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000930:Antidiarrheals; D015532:Rehydration Solutions