title: Topographic relationship between frequency-doubling technology threshold values.
abstract: OBJECTIVE
  To study the topographic relationship of retinal sensitivity evaluated by frequency-doubling perimetry (FDT) in healthy subjects and patients with glaucoma.
  
  
  METHODS
  Hundred and thirty-four eyes from 134 subjects (72 patients with glaucoma and 62 healthy controls) were prospectively and consecutively selected. Only one eye of each subject was randomly selected for evaluation. All subjects underwent a full ophthalmic examination and a reliable FDT (full-threshold C-20-5 algorithm). Pearson correlation coefficients between threshold values within the same hemifield were calculated. Maps of related points were plotted according to these correlation coefficients.
  
  
  RESULTS
  In the control group, each FDT location strongly to moderately correlated with the other FDT locations in the same hemifield. In glaucoma subjects, only a few locations significantly correlated with other threshold values in the same hemifield. The strongest correlations were observed between neighbouring locations. The pairs of points with the strongest correlation corresponded to the inferior retinal regions. In general, perimetric maps showed the retinotopic distribution of ganglion cell axons in the retinal nerve fibre layer.
  
  
  CONCLUSIONS
  The statistical correlations between the FDT threshold values in the same visual hemifield objectively highlight the structure-function relationship determined by the anatomic distribution of retinal nervous tissue. This structure is altered in patients with glaucoma.
authors: Department of Ophthalmology, Aragon Health Sciences Institute, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
authors: Isabel
authors: I
authors: Fuertes-Lazaro
authors: Ana
authors: A
authors: Sanchez-Cano
authors: Antonio
authors: A
authors: Ferreras
authors: Jose M
authors: JM
authors: Larrosa
authors: Elena
authors: E
authors: Garcia-Martin
authors: Luis E
authors: LE
authors: Pablo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult