title: Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age.
abstract: This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The study group consisted of 90 patients; the men were ≤ 50 years old and the women were ≤ 55 years old. Amplicons of exons 4 and 5 including fragments of introns were analyzed by DHPLC. Two polymorphisms were found: IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892). The C allele of the IVS3-6 T/C polymorphism was associated with higher prevalence of obesity and diabetes, higher hsCRP, lower Lp(a) serum concentrations, and younger age at myocardial infarction. The A allele of the IVS4-10 G/A polymorphism was associated with older age of myocardial infarction and higher white blood cell count. The functional role of CD36 polymorphisms in CAD development needs further research.
authors: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. carmon12@gmail.com
authors: Monika Ewa
authors: ME
authors: Rać
authors: Janina
authors: J
authors: Suchy
authors: Grzegorz
authors: G
authors: Kurzawski
authors: Agnieszka
authors: A
authors: Kurlapska
authors: Krzysztof
authors: K
authors: Safranow
authors: Michał
authors: M
authors: Rać
authors: Dagmara
authors: D
authors: Sagasz-Tysiewicz
authors: Andrzej
authors: A
authors: Krzystolik
authors: Wojciech
authors: W
authors: Poncyljusz
authors: Katarzyna
authors: K
authors: Jakubowska
authors: Maria
authors: M
authors: Olszewska
authors: Beata
authors: B
authors: Krupa
authors: Dariusz
authors: D
authors: Chlubek
mesh_terms: D000328:Adult; D018955:CD36 Antigens / Q000235:genetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D009765:Obesity / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D011044:Poland; D011110:Polymorphism, Genetic
chemical_list: D018955:CD36 Antigens