title: The evolution of adjuvant therapy in the treatment of early-stage colon cancer.
abstract: Adjuvant treatment of colon cancer, one of the most common malignancies, is an important issue in oncology. This article describes the development of adjuvant therapy and how the 2 major evolution steps, the successes of fluoropyrimidines, and then of oxaliplatin, have been achieved, Problems and failures, such as those of targeted therapies, also are addressed to help us to overcome their limitations. Special situations, such as stage II disease and an elderly population in which adjuvant chemotherapy is still controversial, are reviewed from the clinician perspective. The synthesis of these data allows us to conceive a future development focused on translational research.
authors: Service d'Oncologie médicale, Hôpital Saint-Antoine, Assistance Publique des Hôpitaux de Paris, Paris, France. aimery.de-gramont@sat.aphp.fr
authors: Aimery
authors: A
authors: de Gramont
authors: Armand
authors: A
authors: de Gramont
authors: Benoist
authors: B
authors: Chibaudel
authors: Annette K
authors: AK
authors: Larsen
authors: Christophe
authors: C
authors: Tournigand
authors: Thierry
authors: T
authors: André
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy*; D006801:Humans; D009367:Neoplasm Staging; D013997:Time Factors; D016896:Treatment Outcome