title: Microsporidial keratoconjunctivitis in an immunocompetent patient with a past history of laser in situ keratomilieusis surgery.
abstract: Ocular infection with microsporidia has been documented in both immunocompetent and immunocompromised patients. Sources and mode of human infection with microsporidia have been difficult to ascertain although exposure to water may be an important risk factor. Of four genera that have been reported in human disease, only the genera Nosema, Encephalitozoon and Septata are documented to cause ocular infection. Here, in our case a healthy 30-year-old man who had undergone bilateral laser in situ keratomilieusis surgery two and half years back presented with a 10-day history of redness and 4-day history of blurring of vision in the right eye. On presentation, his best-corrected visual acuity was 20/20 partial in both eyes. Slit lamp examination revealed multiple pin head shaped infiltrates in the right cornea. Examination of the left eye was unremarkable. Based on microscopic demonstration of numerous microsporidial spores in the corneal scrapings, a diagnosis of microsporidial keratitoconjunctivitis was made. On treatment with oral albendazole, the cornea became clear with complete resolution of symptoms and signs within two weeks.
authors: Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad 500 034, India. bml_1625@yahoo.com
authors: M L
authors: ML
authors: Bommala
authors: S
authors: S
authors: Nalamada
authors: S
authors: S
authors: Sharma
authors: P
authors: P
authors: Garg
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D006801:Humans; D007637:Keratoconjunctivitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D016814:Microsporidia / Q000302:isolation & purification*; D016881:Microsporidiosis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015766:Albendazole