title: Periodically reactivated context memory retains its precision and dependence on the hippocampus.
abstract: Hippocampus is hypothesized to play a temporary role in the retrieval of context memories. Similarly, previous studies have reported that the expression of context memories becomes more generalized as memory ages. We report, first, that contextual fear memory expression changes from being sensitive to dorsal hippocampus inactivation by muscimol at 2 days post-conditioning, to insensitive at 28 days, and second, that over the same period rats lose their ability to discriminate between a novel and conditioned context. Furthermore, we show that repeated brief memory reactivation sessions prevent memory from becoming both hippocampus-independent and generalized.
authors: Laboratório de Psicobiologia e Neurocomputação, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors: Lucas de Oliveira
authors: Lde O
authors: Alvares
authors: Einar Örn
authors: EÖ
authors: Einarsson
authors: Fabiana
authors: F
authors: Santana
authors: Ana Paula
authors: AP
authors: Crestani
authors: Josué
authors: J
authors: Haubrich
authors: Lindsey Freitas
authors: LF
authors: Cassini
authors: Karim
authors: K
authors: Nader
authors: Jorge Alberto
authors: JA
authors: Quillfeldt
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D004597:Electroshock; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D058785:GABA-A Receptor Agonists / Q000008:administration & dosage; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D058785:GABA-A Receptor Agonists; D009118:Muscimol