title: No appetite efficacy of a commercial structured lipid emulsion in minimally processed drinks.
abstract: OBJECTIVE
  Fabuless (Olibra) is a commercially structured lipid emulsion, claimed to be a food ingredient that is effective for food intake and appetite reduction. The present study assessed its efficacy in a yoghurt-based mini-drink undergoing low or minimal food manufacturing (thermal and shear) processes.
  
  
  METHODS
  Study 1: Twenty-four healthy volunteers (16 female, 8 male; age: 18-47 years; body mass index (BMI): 17-28 kg m(-2)) took part in a randomised, placebo-controlled, double-blind parallel crossover trial. Consumption of a minimally processed 'preload' mini-drink (containing two different doses of Fabuless or a control fat) at 2 h after breakfast was followed by appetite and mood ratings, and food intake measured in ad libitum meals at 3 and 7 h post consumption of the preload. Study 2: As Study 1 (16 female, 8 male; age: 20-54 years; BMI: 21-30 kg m(-2)). A chilled, virtually unprocessed, preload breakfast mini-drink (containing minimally processed Fabuless or a control fat) was provided 5 min after a standardised breakfast, followed by appetite and mood ratings, and food intake measured in ad libitum meals at 4 and 8 h post consumption of the preload.
  
  
  RESULTS
  The structured lipid emulsion tested had no significant effect on the primary measures of food intake or appetite.
  
  
  CONCLUSIONS
  Even when exposed to minimal food-manufacturing conditions, Fabuless showed no efficacy on measures of appetite and food intake.
authors: School of Experimental Psychology, University of Bristol, Bristol, UK. henk.smit@bristol.ac.uk
authors: H J
authors: HJ
authors: Smit
authors: E
authors: E
authors: Keenan
authors: E M R
authors: EM
authors: Kovacs
authors: S A
authors: SA
authors: Wiseman
authors: D J
authors: DJ
authors: Mela
authors: P J
authors: PJ
authors: Rogers
mesh_terms: D000704:Analysis of Variance; D001066:Appetite / Q000187:drug effects* / Q000502:physiology; D001067:Appetite Depressants / Q000494:pharmacology*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D004655:Emulsions / Q000494:pharmacology; D002149:Energy Intake / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006801:Humans; D008055:Lipids / Q000494:pharmacology; D008297:Male; D062407:Meals; D008875:Middle Aged; D006113:United Kingdom; D015014:Yogurt; D055815:Young Adult
chemical_list: D001067:Appetite Depressants; D004041:Dietary Fats; D004655:Emulsions; D008055:Lipids