title: Wnt-pathway activation in intestinal-type sinonasal adenocarcinoma.
abstract: Intestinal-type sinonasal adenocarcinoma (ITAC) is an epithelial cancer of the sinonasal sinuses that shows histological similarity to colorectal cancer (CRC) and share chronic inflammation as a possible etiological factor. The Wnt-pathway is one of the most important tumourigenic pathways in CRC. The aim of this study was to investigate if the Wnt-pathway is activated in ITAC.
  
  
  
  Protein expression profiles of E-cadherin, β-catenin, c-myc and cyclin D1 were analysed by immunohistochemistry in 83 samples of ITAC, organized into tissue microarray blocks.
  
  
  
  Nuclear β-catenin expression was observed in 31% of the cases and was twice as frequent in papillary/colonic ITAC compared to solid/mucinous subtypes. Loss of membranous β-catenin staining occurred in 24% and loss of membranous E-cadherin in 6% of the cases and this was more prominent in mucinous types. Strong c-myc and cyclin D1 expression was observed in 30% and 4% of the cases, respectively. Nuclear β-catenin expression was significantly related to poor clinical outcome, independent from established factors as tumour stage and histological type.
  
  
  
  The presence of nuclear β-catenin in 31% of patients with ITACs indicated that in a subset of patients, the Wnt-pathway is active and conveys a worse prognosis.
authors: Dept. of Otolaryngology, IUOPA, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors: Juan Pablo
authors: JP
authors: Díaz-Molina
authors: José Luis
authors: JL
authors: Llorente
authors: Blanca
authors: B
authors: Vivanco
authors: Pablo
authors: P
authors: Martínez-Camblor
authors: Manuel Florentino
authors: MF
authors: Fresno
authors: Jhudit
authors: J
authors: Pérez-Escuredo
authors: César
authors: C
authors: Álvarez-Marcos
authors: Mario A
authors: MA
authors: Hermsen
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism; D019938:Cyclin D1 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D011379:Prognosis; D040081:Protein Array Analysis; D014157:Transcription Factors / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D015820:Cadherins; D004268:DNA-Binding Proteins; C116115:MYCBP protein, human; D014157:Transcription Factors; D051176:beta Catenin; D019938:Cyclin D1