title: Skull base surgery for pediatric parameningeal sarcomas.
abstract: BACKGROUND
  Localized pediatric parameningeal sarcomas are usually treated exclusively by chemotherapy and radiotherapy. In this location, surgery is complicated but sometimes attempted to improve local control.
  
  
  METHODS
  A retrospective bicentric study was conducted to examine its place with particular reference to acute and long-term morbidity. Fifteen patients under the age of 20 years with parameningeal sarcoma underwent surgery between 2000 and 2007.
  
  
  RESULTS
  Surgery was performed for 8 primary sarcomas and 7 radiation-induced sarcomas, mainly in infratemporal fossa. Three children had intracranial extension, 3 had metastases, and 1 had both. Median follow-up was 46 months (16-154 months). Five children experienced local relapse. Eight presented sequelae. Eleven children are alive with no evidence of disease, and 4 died.
  
  
  CONCLUSIONS
  Skull base surgery should be considered as a possible treatment in pediatric parameningeal sarcomas. Surgery is the only option in radiation-induced sarcoma. Larger studies are necessary to more clearly define surgical indications.
authors: Department of Pediatric ENT Surgery, Robert Debré Hospital, Paris, France.
authors: Sophie
authors: S
authors: Deneuve
authors: Natacha
authors: N
authors: Teissier
authors: Thomas
authors: T
authors: Jouffroy
authors: Sylvie
authors: S
authors: Helfre
authors: Hervé
authors: H
authors: Boissonnet
authors: Paul
authors: P
authors: Freneaux
authors: Michel
authors: M
authors: Peuchmaur
authors: Hervé
authors: H
authors: Brisse
authors: Thierry
authors: T
authors: Van Den Abbeele
authors: Daniel
authors: D
authors: Orbach
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008577:Meningeal Neoplasms / Q000401:mortality / Q000628:therapy*; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000628:therapy*; D019291:Skull Base / Q000601:surgery*; D055815:Young Adult