title: Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair.
abstract: BACKGROUND
  HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established.
  
  
  METHODS
  We designed a multicentre, prospective, randomised, open label trial to evaluate the effect of the HMGcoA-reductase-inhibitor (Atorvastatin) on atherosclerotic progression in adult post-coarctectomy patients. The primary endpoint in this study is the carotid intima-media thickness as measured by Bmode ultrasonography of the carotid arteries.
  
  
  CONCLUSIONS
  This large prospective, randomised, open label trial will establish the effect of HMG-coA-reductase inhibitors (Atorvastatin) on cardiovascular risk in adult patients after successful coarctation repair.
authors: Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors: Paul
authors: P
authors: Luijendijk
authors: Berto J
authors: BJ
authors: Bouma
authors: Joris W J
authors: JW
authors: Vriend
authors: Maarten
authors: M
authors: Groenink
authors: Hubert W
authors: HW
authors: Vliegen
authors: Eric
authors: E
authors: de Groot
authors: Petronella G
authors: PG
authors: Pieper
authors: Arie P J
authors: AP
authors: van Dijk
authors: Gertjan T
authors: GT
authors: Sieswerda
authors: Gerrit
authors: G
authors: Veen
authors: Aeilko H
authors: AH
authors: Zwinderman
authors: Barbara J M
authors: BJ
authors: Mulder
mesh_terms: D000328:Adult; D001017:Aortic Coarctation / Q000150:complications / Q000601:surgery*; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000069059:Atorvastatin; D006348:Cardiac Surgical Procedures; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006538:Heptanoic Acids / Q000008:administration & dosage*; D049690:History, Ancient; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D011758:Pyrroles / Q000008:administration & dosage*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin