title: Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization.
abstract: OBJECTIVE
  The aim of the present study was to analyze the long-term outcome of cervical intraepithelial neoplasia 3 (CIN 3) after treatment with the Shimodaira-Taniguchi conization procedure, based on the status of the resection margins.
  
  
  METHODS
  In the Osaka University Hospital, conization using the Shimodaira-Taniguchi procedure has been routinely performed for CIN 3. Medical records of patients during the period from 2001 to 2008, whose post-conization diagnosis was CIN 3, were retrospectively analyzed for outcome versus margin status.
  
  
  RESULTS
  During the median follow-up period of 565 days (range 34-3,013), CIN disease was again detected in 14 of 243 patients; it was found in 7 patients among 198 margin-negative cases, and in 7 patients among 45 margin-positive cases. There was a significant difference in the reappearance rate demonstrated between the cases with positive and negative margins (p = 0.0018). Among the patients whose first follow-up post-conization cytology was normal, recurrence-free probability was significantly higher in margin-negative cases than in margin-positive ones (hazard ratio, 5.19; 95% CI, 1.175-22.994; p = 0.0041).
  
  
  CONCLUSIONS
  For the first time, we demonstrate that after treatment of CIN 3 lesions by Shimodaira-Taniguchi conization the status of the resection margin was a significant predictor for long-term outcome.
authors: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Yukari
authors: Y
authors: Miyoshi
authors: Takashi
authors: T
authors: Miyatake
authors: Yutaka
authors: Y
authors: Ueda
authors: Akiko
authors: A
authors: Morimoto
authors: Takuhei
authors: T
authors: Yokoyama
authors: Shinya
authors: S
authors: Matsuzaki
authors: Toshihiro
authors: T
authors: Kimura
authors: Kiyoshi
authors: K
authors: Yoshino
authors: Masami
authors: M
authors: Fujita
authors: Hiroshi
authors: H
authors: Ohashi
authors: Eiichi
authors: E
authors: Morii
authors: Takayuki
authors: T
authors: Enomoto
authors: Tadashi
authors: T
authors: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D019092:Conization / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000601:surgery*