title: Prompt initiation of ART With therapeutic food is associated with improved outcomes in HIV-infected Malawian children with malnutrition.
abstract: This retrospective observational study of 140 HIV-infected children with uncomplicated malnutrition in urban Malawi tested the hypothesis that initiation of antiretroviral therapy (ART) within 21 days of outpatient therapeutic feeding (prompt ART) improved clinical outcomes. Children receiving prompt ART were more likely to recover nutritionally (86% vs. 60%, P < 0.01) and had higher rates of weight gain (3.6 vs. 1.6 g/k/day; P = 0.02). Logistic regression modeling found prompt ART was associated with increased likelihood of nutritional recovery (odds ratio: 5.4, 95% confidence interval: 2.0 to 14.5). This suggests that prompt ART is associated with improved outcomes in HIV-infected Malawian children with uncomplicated malnutrition.
authors: Baylor College of Medicine International Pediatrics AIDS Initiative at Texas Children's Hospital, Houston, TX, USA. mhkim@bcm.edu
authors: Maria H
authors: MH
authors: Kim
authors: Carrie
authors: C
authors: Cox
authors: Anjalee
authors: A
authors: Dave
authors: Heather R
authors: HR
authors: Draper
authors: Mark
authors: M
authors: Kabue
authors: Gordon E
authors: GE
authors: Schutze
authors: Saeed
authors: S
authors: Ahmed
authors: Peter N
authors: PN
authors: Kazembe
authors: Mark W
authors: MW
authors: Kline
authors: Mark
authors: M
authors: Manary
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005526:Food, Formulated; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008295:Malawi; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000178:diet therapy*; D012189:Retrospective Studies
chemical_list: D019380:Anti-HIV Agents