title: Drug release from electric-field-responsive nanoparticles.
abstract: We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.
authors: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
authors: Jun
authors: J
authors: Ge
authors: Evgenios
authors: E
authors: Neofytou
authors: Thomas J
authors: TJ
authors: Cahill
authors: Ramin E
authors: RE
authors: Beygui
authors: Richard N
authors: RN
authors: Zare
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects*; D004058:Diffusion; D004574:Electromagnetic Fields; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000528:radiation effects; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects*
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D004364:Pharmaceutical Preparations; D011108:Polymers