title: Processed nerve allografts for peripheral nerve reconstruction: a multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions.
abstract: OBJECTIVE
  As alternatives to autograft become more conventional, clinical outcomes data on their effectiveness in restoring meaningful function is essential. In this study we report on the outcomes from a multicenter study on processed nerve allografts (Avance® Nerve Graft, AxoGen, Inc).
  
  
  METHODS
  Twelve sites with 25 surgeons contributed data from 132 individual nerve injuries. Data was analyzed to determine the safety and efficacy of the nerve allograft. Sufficient data for efficacy analysis were reported in 76 injuries (49 sensory, 18 mixed, and 9 motor nerves). The mean age was 41 ± 17 (18-86) years. The mean graft length was 22 ± 11 (5-50) mm. Subgroup analysis was performed to determine the relationship to factors known to influence outcomes of nerve repair such as nerve type, gap length, patient age, time to repair, age of injury, and mechanism of injury.
  
  
  RESULTS
  Meaningful recovery was reported in 87% of the repairs reporting quantitative data. Subgroup analysis demonstrated consistency, showing no significant differences with regard to recovery outcomes between the groups (P > 0.05 Fisher's Exact Test). No graft related adverse experiences were reported and a 5% revision rate was observed.
  
  
  CONCLUSIONS
  Processed nerve allografts performed well and were found to be safe and effective in sensory, mixed and motor nerve defects between 5 and 50 mm. The outcomes for safety and meaningful recovery observed in this study compare favorably to those reported in the literature for nerve autograft and are higher than those reported for nerve conduits.
authors: The Buncke Clinic, San Francisco, CA 94114, USA. Rangerstudy@gmail.com
authors: Darrell N
authors: DN
authors: Brooks
authors: Renata V
authors: RV
authors: Weber
authors: Jerome D
authors: JD
authors: Chao
authors: Brian D
authors: BD
authors: Rinker
authors: Jozef
authors: J
authors: Zoldos
authors: Michael R
authors: MR
authors: Robichaux
authors: Sebastian B
authors: SB
authors: Ruggeri
authors: Kurt A
authors: KA
authors: Anderson
authors: Ekkehard E
authors: EE
authors: Bonatz
authors: Scott M
authors: SM
authors: Wisotsky
authors: Mickey S
authors: MS
authors: Cho
authors: Christopher
authors: C
authors: Wilson
authors: Ellis O
authors: EO
authors: Cooper
authors: John V
authors: JV
authors: Ingari
authors: Bauback
authors: B
authors: Safa
authors: Brian M
authors: BM
authors: Parrett
authors: Gregory M
authors: GM
authors: Buncke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods; D010525:Peripheral Nerves / Q000601:surgery* / Q000637:transplantation; D019651:Plastic Surgery Procedures; D013242:Sterilization; D014184:Transplantation, Homologous; D055815:Young Adult