title: Animal models of dyssynchrony.
abstract: Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.
authors: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. m.strik@maastrichtuniversity.nl
authors: Marc
authors: M
authors: Strik
authors: Lars B
authors: LB
authors: van Middendorp
authors: Kevin
authors: K
authors: Vernooy
mesh_terms: D000818:Animals; D002037:Bundle-Branch Block / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D058406:Cardiac Resynchronization Therapy; D004195:Disease Models, Animal; D004452:Echocardiography; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009200:Myocardial Contraction; D011379:Prognosis; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016277:Ventricular Function, Left / Q000502:physiology*