title: Osseointegration of SLActive implants in diabetic pigs.
abstract: OBJECTIVE
  Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri-implant bone formation in a diabetic animal model in comparison to healthy animals and to evaluate the differences between conventional (SLA(®) ) and modified (SLActive(®) ) titanium implant surfaces on osseointegration.
  
  
  METHODS
  Each six implants were placed in the calvaria of 11 diabetic and 4 healthy domestic pigs. At 30 and 90 days after implant placement, the bone-to-implant contact (BIC) and bone density (BD) were appraised. Additionally, the expression of the bone-matrix proteins collagen type I and osteocalcin was evaluated at both points in time by using immunohistochemical staining methods.
  
  
  RESULTS
  Overall, BIC was reduced in the diabetic group at 30 and 90 days. After 90 days, the SLActive(®)  implants showed significantly higher BICs compared with the SLA(®)  implants in diabetic animals. Peri-implant BD was higher in the SLActive(®)  group at 30 and 90 days in healthy and diabetic animals. Collagen type I protein expression was higher using SLA(®)  implants in diabetic pigs at 30 days. Values for osteocalcin expression were not consistent.
  
  
  CONCLUSIONS
  The results indicate the negative effect of untreated diabetes mellitus on early osseointegration of dental implants. The modified SLA(®)  surface (SLActive(®) ) elicited an accelerated osseointegration of dental implants, suggesting that a better prognosis for implant treatment of diabetic patients is possible.
authors: Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
authors: K A
authors: KA
authors: Schlegel
authors: C
authors: C
authors: Prechtl
authors: T
authors: T
authors: Möst
authors: C
authors: C
authors: Seidl
authors: R
authors: R
authors: Lutz
authors: C
authors: C
authors: von Wilmowsky
mesh_terms: D000818:Animals; D015519:Bone Density; D001861:Bone Regeneration; D024042:Collagen Type I / Q000378:metabolism; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019232:Dental Restoration Failure; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D016348:Osseointegration / Q000187:drug effects*; D015675:Osteocalcin / Q000378:metabolism; D012886:Skull / Q000601:surgery*; D013499:Surface Properties; D013552:Swine; D014025:Titanium / Q000494:pharmacology*
chemical_list: D024042:Collagen Type I; D015921:Dental Implants; D015675:Osteocalcin; D014025:Titanium