title: Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate.
abstract: In contrast to the Pt(IV) derivatives of cisplatin, Pt(IV) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
authors: School of Chemistry, The University of Sydney, NSW 2006, Australia.
authors: Jenny Z
authors: JZ
authors: Zhang
authors: Ezequiel
authors: E
authors: Wexselblatt
authors: Trevor W
authors: TW
authors: Hambley
authors: Dan
authors: D
authors: Gibson
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry*; D000077150:Oxaliplatin; D010084:Oxidation-Reduction; D011355:Prodrugs / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011355:Prodrugs; D000077150:Oxaliplatin; D001205:Ascorbic Acid