title: Effectiveness of rotavirus vaccines in preventing cases and hospitalizations due to rotavirus gastroenteritis in Navarre, Spain.
abstract: Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and June 2011. About 9% had received the pentavalent vaccine (RotaTeq) and another 8% received the monovalent vaccine (Rotarix). Cases were the 756 children with confirmed rotavirus and controls were the 6036 children who tested negative for rotavirus. Thirty-five percent of cases and 9% of controls had required hospitalization (p<0.0001). The adjusted effectiveness of complete vaccination was 78% (95% CI: 68-85%) in preventing rotavirus gastroenteritis and 83% (95% CI: 65-93%) in preventing hospitalization for rotavirus gastroenteritis. No differences between the two vaccines were detected (p=0.4523). Both vaccines were highly effective in preventing cases and hospital admissions in children due to rotavirus gastroenteritis.
authors: Instituto de Salud Pública de Navarra, Pamplona, Spain. jcastilc@navarra.es
authors: Jesús
authors: J
authors: Castilla
authors: Xabier
authors: X
authors: Beristain
authors: Víctor
authors: V
authors: Martínez-Artola
authors: Ana
authors: A
authors: Navascués
authors: Manuel
authors: M
authors: García Cenoz
authors: Nerea
authors: N
authors: Alvarez
authors: Isabel
authors: I
authors: Polo
authors: Ana
authors: A
authors: Mazón
authors: Alberto
authors: A
authors: Gil-Setas
authors: Aurelio
authors: A
authors: Barricarte
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008297:Male; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D013030:Spain
chemical_list: D022243:Rotavirus Vaccines