title: Redox regulation of p53, redox effectors regulated by p53: a subtle balance.
abstract: CONCLUSIONS
  Reactive oxygen species (ROS), generated by cells as side products of biological reactions, function as secondary messengers by impacting a host of cellular networks involved in maintaining normal homeostatic growth as well as pathological disease states. Redox-sensitive proteins, such as the tumor suppressor protein p53, are susceptible to ROS-dependent modifications, which could impact their activities and/or biological functions.
  
  
  BACKGROUND
  p53 is a transcription factor that controls a wide variety of target genes and regulates numerous cellular functions in response to stresses that lead to genomic instability. Thus, redox modifications of p53 could impact cell fate signaling and could have profound effects on pathways fundamental to maintaining cell and tissue integrity.
  
  
  RESULTS
  Recent studies present evidence that ROS function upstream of p53 in some model systems, while in others ROS production could be a downstream effect of p53 activation.
  
  
  CONCLUSIONS
  In this review, we describe how ROS production regulates p53 activity and how p53 can, in turn, influence cellular ROS production.
authors: ROS, Apoptosis and Cancer Biology Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors: Agnès
authors: A
authors: Maillet
authors: Shazib
authors: S
authors: Pervaiz
mesh_terms: D000818:Animals; D006801:Humans; D010084:Oxidation-Reduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53