title: Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs.
abstract: OBJECTIVE
  To determine the effect of maropitant, an NK-1 receptor antagonist on the minimum alveolar concentration (MAC) of sevoflurane after intravenous and epidural administration to dogs.
  
  
  METHODS
  Prospective experimental study.
  
  
  METHODS
  Seven, adult, spayed-female dogs (24.8 ± 1.9 kg).
  
  
  METHODS
  Each dog was anesthetized twice with sevoflurane in oxygen, with at least 10 days separating the anesthetic events. The minimum alveolar concentration (MAC) of sevoflurane was determined using the tail-clamp technique. During the first anesthetic event, the MAC of sevoflurane was determined initially and again after intravenous administration of maropitant (5 mg kg(-1)) and an infusion (150 μg kg(-1) hour(-1)). During the second anesthetic event, an epidural catheter was advanced to the 4th lumbar vertebra and MAC was determined after administration of saline and maropitant (1 mg kg(-1)) epidurally. All MAC determinations were done in duplicate. The MAC values were adjusted to sea level and compared using student's t-test.
  
  
  RESULTS
  The baseline MAC for sevoflurane was 2.08 ± 0.25%. Intravenous maropitant decreased (p < 0.05) MAC by 16% (1.74 ± 0.17%). In contrast, epidural administration of either saline or maropitant did not change (p > 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively).
  
  
  CONCLUSIONS
  Maropitant decreased the MAC of sevoflurane when administered intravenously to dogs but not after epidural administration.
authors: College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
authors: Brittany M
authors: BM
authors: Alvillar
authors: Pedro
authors: P
authors: Boscan
authors: Khursheed R
authors: KR
authors: Mama
authors: Tatiana H
authors: TH
authors: Ferreira
authors: Jonathan
authors: J
authors: Congdon
authors: David C
authors: DC
authors: Twedt
mesh_terms: D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000032:analysis; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007268:Injections, Epidural / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008738:Methyl Ethers / Q000008:administration & dosage / Q000032:analysis; D064729:Neurokinin-1 Receptor Antagonists; D011650:Pulmonary Alveoli / Q000737:chemistry; D011812:Quinuclidines / Q000008:administration & dosage / Q000494:pharmacology*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D008738:Methyl Ethers; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D000077149:Sevoflurane; C518176:maropitant