title: ELM--the database of eukaryotic linear motifs.
abstract: Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
authors: Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Holger
authors: H
authors: Dinkel
authors: Sushama
authors: S
authors: Michael
authors: Robert J
authors: RJ
authors: Weatheritt
authors: Norman E
authors: NE
authors: Davey
authors: Kim
authors: K
authors: Van Roey
authors: Brigitte
authors: B
authors: Altenberg
authors: Grischa
authors: G
authors: Toedt
authors: Bora
authors: B
authors: Uyar
authors: Markus
authors: M
authors: Seiler
authors: Aidan
authors: A
authors: Budd
authors: Lisa
authors: L
authors: Jödicke
authors: Marcel A
authors: MA
authors: Dammert
authors: Christian
authors: C
authors: Schroeter
authors: Maria
authors: M
authors: Hammer
authors: Tobias
authors: T
authors: Schmidt
authors: Peter
authors: P
authors: Jehl
authors: Caroline
authors: C
authors: McGuigan
authors: Magdalena
authors: M
authors: Dymecka
authors: Claudia
authors: C
authors: Chica
authors: Katja
authors: K
authors: Luck
authors: Allegra
authors: A
authors: Via
authors: Andrew
authors: A
authors: Chatr-Aryamontri
authors: Niall
authors: N
authors: Haslam
authors: Gleb
authors: G
authors: Grebnev
authors: Richard J
authors: RJ
authors: Edwards
authors: Michel O
authors: MO
authors: Steinmetz
authors: Heike
authors: H
authors: Meiselbach
authors: Francesca
authors: F
authors: Diella
authors: Toby J
authors: TJ
authors: Gibson
mesh_terms: D020816:Amino Acid Motifs; D003196:Computer Graphics; D030562:Databases, Protein; D004194:Disease / Q000235:genetics; D056890:Eukaryota; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface; D014764:Viral Proteins / Q000737:chemistry
chemical_list: D014764:Viral Proteins