title: Coexistent findings of renal glomerular disease with Hashimoto's thyroiditis.
abstract: OBJECTIVE
  Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease with a female preponderance. Renal involvement in HT is not uncommon. In the present study, we aimed to define the frequency and characteristics of the glomerular diseases associated with HT and further the understanding of any common pathogenesis between HT and glomerular disease.
  
  
  METHODS
  We reviewed retrospectively 28 patients with HT who were referred to our Department because of unexplained haematuria, proteinuria or renal impairment from 2007 to 2011. Routine laboratory investigations including blood count, serum biochemistry, urinalysis and 24-h urinary protein excretion were performed on all patients. Renal biopsy was performed in 20 patients with HT, and the specimens were examined by light microscopy and immunofluorescence staining.
  
  
  RESULTS
  We detected four cases of focal segmental glomerulosclerosis (FSGS), four membranous glomerulonephritis (MGN), two minimal-change disease (MCD), three immunoglobulin A nephritis (IgAN), three chronic glomerulonephritis (CGN) and one amyloidosis. In three patients, the renal biopsy findings were nonspecific. Daily urinary protein excretion and glomerular filtration rates were found to be independent of the level of thyroid hormone and thyroid-specific autoantibodies.
  
  
  CONCLUSIONS
  Glomerular pathologies associated with HT are similar to those in the general population, the most common lesions being MGN, FSGS and IgA nephritis.
authors: Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey. gulaykad@hotmail.com
authors: Gülay
authors: G
authors: Koçak
authors: Bülent
authors: B
authors: Huddam
authors: Alper
authors: A
authors: Azak
authors: Levent
authors: L
authors: Ortabozkoyun
authors: Murat
authors: M
authors: Duranay
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000453:epidemiology / Q000473:pathology; D001706:Biopsy; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000453:epidemiology / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000453:epidemiology / Q000473:pathology; D050031:Hashimoto Disease / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology