title: The impact of off-pump coronary artery bypass surgery on postoperative renal function.
abstract: OBJECTIVE
  A number of risk factors have been recognised for postoperative renal dysfunction following on-pump coronary artery bypass surgery (CABG). There are, however, few studies that have evaluated the potential reno-protective effects of off-pump CABG in the presence of other confounding risk factors. The aim of this study was to determine if off-pump CABG reduces the risk of renal injury.
  
  
  METHODS
  Serum creatinine values (preoperatively and day 1, 2 and 4 postoperatively) and other clinical data were prospectively collected on 1580 consecutive patients who underwent first-time CABG from 2002 to 2005. Creatinine clearance was calculated using the Cockcroft and Gault equation. The effect of on-pump vs. off-pump CABG on renal function was analysed, adjusting for age, gender, diabetes mellitus, left ventricular (LV) function and preoperative creatinine clearance, using multiple regression analysis.
  
  
  RESULTS
  One thousand one hundred and forty-five (73%) patients underwent on-pump CABG and 435 (27%) underwent off-pump CABG. The two groups were similar with respect to age, gender and diabetes. Two hundred and seventy-four (17%) patients were females and 274 (17%) patients had diabetes. Multivariate analysis demonstrated significantly lower creatinine clearance postoperatively in patients with diabetes (P<0.001) and advanced age (P<0.001). The on-pump group had significantly lower postoperative creatinine clearance in comparison to the off-pump group (P= 0.01). The effect remained consistent after adjusting for potential risk factors (age, diabetes, gender, LV function and preoperative creatinine clearance) in the multivariate analysis.
  
  
  CONCLUSIONS
  Off-pump surgery is associated with a reduction in postoperative renal injury.
authors: Department of Cardiothoracic Surgery, Papworth Hospital NHS Trust, Cambridge, UK. y.abuomar@nhs.net
authors: Y
authors: Y
authors: Abu-Omar
authors: F J
authors: FJ
authors: Taghavi
authors: M
authors: M
authors: Navaratnarajah
authors: A
authors: A
authors: Ali
authors: A
authors: A
authors: Shahir
authors: L-M
authors: LM
authors: Yu
authors: C K
authors: CK
authors: Choong
authors: D P
authors: DP
authors: Taggart
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011184:Postoperative Period; D012307:Risk Factors
chemical_list: D003404:Creatinine