title: [A case of rheumatoid arthritis involving disseminated torichosporonosis].
abstract: A 75-year-old man who developed disseminated trichosporonosis had a long history of immunosuppressive therapy with weekly methotrexate and low-dose prednisolone for rheumatoid arthritis (RA). He had been administered 30 mg of prednisolone per day for organizing pneumonia, probably due to the RA, for about 3 months before admission for a lumbar compression fracture. He then developed bilateral aspiration pneumonia with pleural effusion, treated successfully with broad-spectrum antibiotics meropenem and ciprofloxacin, and fluid management. He then developed acute, progressive respiratory failure with changes in both lung lobes in chest computed tomography (CT). Meropenem, ciprofloxacin, micafungin, and pulsed steroid administration were ineffective. He died of respiratory failure, after which Trichosporon asahii was first detected in blood and urine culture. Disseminated trichosporonosis was determined based on positive blood culture, elevated serum glucuronoxylomannan antigen and beta-D glucan, and the man's lack of clinical progress. He had numerous risk factors for trichosporonosis, including neutrophilic dysfunction due to prolonged steroid therapy, administration of broad-spectrum antibiotics and micafungin, and central venous catheterization. Disseminated trichosporonosis is a chiefly hematological infection and case reports without hematological disorders are rare, so we report this instructive case.
authors: Division of Rheumatic Disease, National Center for Global Health and Medicine.
authors: Yo
authors: Y
authors: Ueda
authors: Hiroyuki
authors: H
authors: Yamashita
authors: Yuji
authors: Y
authors: Yoshida
authors: Yuko
authors: Y
authors: Takahashi
authors: Akio
authors: A
authors: Mimori
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D021821:Communicable Diseases, Emerging / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D013256:Steroids / Q000009:adverse effects; D060586:Trichosporonosis / Q000209:etiology*
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids