title: Transcription co-activator SAYP mediates the action of STAT activator.
abstract: Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven transcription of numerous genes. Mutation of SAYP leads to maldevelopments similar to those observed in STAT mutants. Thus, SAYP is a novel co-activator mediating the action of STAT.
authors: Department of Regulation of Genes Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia.
authors: Vladislav V
authors: VV
authors: Panov
authors: Julia L
authors: JL
authors: Kuzmina
authors: Semen A
authors: SA
authors: Doronin
authors: Marina R
authors: MR
authors: Kopantseva
authors: Elena N
authors: EN
authors: Nabirochkina
authors: Sofia G
authors: SG
authors: Georgieva
authors: Nadezhda E
authors: NE
authors: Vorobyeva
authors: Yulii V
authors: YV
authors: Shidlovskii
mesh_terms: D000818:Animals; D002460:Cell Line; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010641:Phenotype; D054730:Protein Interaction Domains and Motifs; D050791:STAT Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D029721:Drosophila Proteins; D050791:STAT Transcription Factors; D014157:Transcription Factors; C499490:e(y)3 protein, Drosophila