title: Acylated flavonol glycoside from Platanus orientalis.
abstract: The ethylacetate and n-butanol fractions of ethanolic extract of Platanus orientalis leaves led to the isolation of new acylated flavonol glycoside as 3',5,7-trihydroxy-4'-methoxyflavonol 3-[O-2-O-(2,4-Dihydroxy)-E-cinnamoyl-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl (1→2)]-β-D-glucopyranoside, along with seven known compounds. All the compounds were characterized by NMR including 2D NMR techniques. The isolates were evaluated for NF-κB, nitric oxide (NO), aromatase and QR2 chemoprevention activities and some of them appeared to be modestly active.
authors: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, United States. mtantry@olemiss.edu
authors: Mudasir A
authors: MA
authors: Tantry
authors: Seema
authors: S
authors: Akbar
authors: Javid A
authors: JA
authors: Dar
authors: Syed
authors: S
authors: Irtiza
authors: Ahmed
authors: A
authors: Galal
authors: Mohammad A
authors: MA
authors: Khuroo
authors: Khalid
authors: K
authors: Ghazanfar
mesh_terms: D000215:Acylation; D001141:Aromatase / Q000378:metabolism; D002460:Cell Line; D018890:Chemoprevention; D005260:Female; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011808:Quinone Reductases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D044948:Flavonols; D006027:Glycosides; D016328:NF-kappa B; D010936:Plant Extracts; D009569:Nitric Oxide; D001141:Aromatase; C419642:NRH - quinone oxidoreductase2; D011808:Quinone Reductases