title: Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents.
abstract: Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO(2) release profiles with half-lives of SO(2) release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting  Mycobacterium tuberculosis  (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM).
authors: Department of Chemistry, Indian Institute of Science Education and Research, Pune 411 008, India.
authors: Satish R
authors: SR
authors: Malwal
authors: Dharmarajan
authors: D
authors: Sriram
authors: Perumal
authors: P
authors: Yogeeswari
authors: V Badireenath
authors: VB
authors: Konkimalla
authors: Harinath
authors: H
authors: Chakrapani
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003545:Cysteine / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000378:metabolism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013458:Sulfur Dioxide / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D000995:Antitubercular Agents; D003545:Cysteine; D013449:Sulfonamides; D013458:Sulfur Dioxide; C570923:N-benzyl-2,4-dinitrobenzenesulfonamide; D000096926:Benzenesulfonamides