title: Synthesis of chromans via Pd-catalyzed alkene carboetherification reactions.
abstract: A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C-O bond and a C-C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives.
authors: University of Michigan, Department of Chemistry, 930 N. University Ave., Ann Arbor, MI 48109-1055, USA.
authors: Amanda F
authors: AF
authors: Ward
authors: Yan
authors: Y
authors: Xu
authors: John P
authors: JP
authors: Wolfe
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002839:Chromans; D004987:Ethers; D010165:Palladium