title: Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications.
abstract: Modified Portland cement porous scaffolds with suitable characteristics for load-bearing bone tissue engineering applications were manufactured by combining the particulate leaching and foaming methods. Non-crosslinked polydimethylsiloxane was evaluated as a potential reinforcing material. The scaffolds presented average porosities between 70 and 80% with mean pore sizes ranging from 300 μm up to 5.0 mm. Non-reinforced scaffolds presented compressive strengths and elastic modulus values of 2.6 and 245 MPa, respectively, whereas reinforced scaffolds exhibited 4.2 and 443 MPa, respectively, an increase of ∼62 and 80%. Portland cement scaffolds supported human osteoblast-like cell adhesion, spreading, and propagation (t = 1-28 days). Cell metabolism and alkaline phosphatase activity were found to be enhanced at longer culture intervals (t ≥ 14 days). These results suggest the possibility of obtaining strong and biocompatible scaffolds for bone repair applications from inexpensive, yet technologically advanced materials such as Portland cement.
authors: Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210; Grupo de Investigación en Ingeniería Biomédica EIA-CES (GIBEC), Sabaneta, Colombia.
authors: Natalia
authors: N
authors: Higuita-Castro
authors: Daniel
authors: D
authors: Gallego-Perez
authors: Alejandro
authors: A
authors: Pelaez-Vargas
authors: Felipe
authors: F
authors: García Quiroz
authors: Olga M
authors: OM
authors: Posada
authors: Luis E
authors: LE
authors: López
authors: Carlos A
authors: CA
authors: Sarassa
authors: Piedad
authors: P
authors: Agudelo-Florez
authors: Fernando J
authors: FJ
authors: Monteiro
authors: Alan S
authors: AS
authors: Litsky
authors: Derek J
authors: DJ
authors: Hansford
mesh_terms: D001843:Bone Cements / Q000737:chemistry*; D002460:Cell Line; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D016474:Weight-Bearing
chemical_list: D001843:Bone Cements; D004129:Dimethylpolysiloxanes; C013830:baysilon