title: Twenty years of Alzheimer's disease-causing mutations.
abstract: In this study, we review our finding of APP mutations in Alzheimer's disease in 1990-1991 with the benefit of 20 years' perspective. We discuss the historical context in which we made the finding, its immediate and continuing effects on research activity and our hopes for successful clinical testing of the hypothesis. We also briefly discuss the effects finding APP mutations has had on our own careers and those of our colleagues from 1991.
authors: Departments of Psychiatry, Neurology & Genetics, Washington University School of Medicine, St Louis, Missouri, USA.
authors: Alison
authors: A
authors: Goate
authors: Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, UCL Institute of Neurology, London, UK.
authors: John
authors: J
authors: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D056426:Genetic Loci; D006801:Humans; D009154:Mutation / Q000235:genetics*; D058225:Plaque, Amyloid / Q000737:chemistry / Q000209:etiology / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor