title: Mitochondrial targeting of a cationic amphiphilic polyproline helix.
abstract: The development of cell penetrating peptides (CPPs) for the cellular delivery of attached cargo is an area of growing interest. Many CPPs, however, are found trapped within endosomes, thereby limiting their use as drug delivery agents with sub-cellular applications. Herein, we detail the properties of a highly efficient class of CPPs, cationic amphiphilic polyproline helices (CAPHs), that are found localized to the mitochondria by direct transport into cells.
authors: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
authors: Deanna
authors: D
authors: Kalafut
authors: Tiffani N
authors: TN
authors: Anderson
authors: Jean
authors: J
authors: Chmielewski
mesh_terms: D001692:Biological Transport; D002412:Cations; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D015195:Drug Design; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*
chemical_list: D002412:Cations; D010455:Peptides; C011083:polyproline