title: Chronic dietary fiber supplementation with wheat dextrin does not inhibit calcium and magnesium absorption in premenopausal and postmenopausal women.
abstract: This placebo-controlled, randomized, crossover clinical study examined the effect of chronic wheat dextrin intake on calcium and magnesium absorption. Forty premenopausal and post menopausal women (mean ± SD age 49.9 ± 9.8 years) consumed wheat dextrin or placebo (15 g/day)  for 2 weeks prior to (45)calcium ((45)Ca) and (26)magnesium ((26)Mg) absorption testing. After a standardized breakfast, serial blood and urine samples were obtained. The mean ± SD area under the curve from 0 to 9 h for (45)Ca specific activity  was 0.81 ± 0.21 for wheat dextrin and 0.82 ± 0.22 for placebo, showing that wheat dextrin had no effect on calcium absorption. The mean ± SD percentage excess of (26)Mg/(24)Mg was 7.8% ± 2.1% for wheat dextrin and 7.9% ± 2.6% for placebo,  showing that wheat dextrin had no effect on magnesium absorption. In conclusion, chronic wheat dextrin consumption did not inhibit calcium or magnesium absorption from the gastrointestinal tract in women.
authors: Osteoporosis Research Center, Creighton University, 601 North 30th Street, Suite 4820, Omaha, NE 68131, USA. larmas@creighton.edu
authors: L A G
authors: LA
authors: Armas
authors: K
authors: K
authors: Rafferty
authors: A
authors: A
authors: Hospattankar
authors: S A
authors: SA
authors: Abrams
authors: R P
authors: RP
authors: Heaney
mesh_terms: D000042:Absorption; D000328:Adult; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D018592:Cross-Over Studies; D003912:Dextrins / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D017698:Postmenopause; D017697:Premenopause; D014908:Triticum / Q000737:chemistry; D014807:Vitamin D / Q000097:blood
chemical_list: D003912:Dextrins; D010936:Plant Extracts; D014807:Vitamin D; D008274:Magnesium; D002118:Calcium