title: Synthesis of novel cinnamanilides as potential immunosuppressive agents.
abstract: A series of new cinnamanilides (6-40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methoxy-3-(4-methoxyphenyl)acrylamide (37) and (Z)-2-methoxy-3-(4-methoxyphenyl)-N-p-tolylacrylamide (38) exhibited potent immunosuppressive activity (IC(50) = 1.77 ± 0.33 and 0.94 ± 0.13 μM) without significant cytotoxicity.
authors: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China. shilei0828@gmail.com
authors: Lei
authors: L
authors: Shi
authors: Lu
authors: L
authors: Wang
authors: Zhi
authors: Z
authors: Wang
authors: Hai-Liang
authors: HL
authors: Zhu
authors: Qiao
authors: Q
authors: Song
mesh_terms: D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D005260:Female; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000813:Anilides; D007166:Immunosuppressive Agents