title: New aspects in the clinical spectrum of neonatal lupus.
abstract: Neonatal lupus erythematosus (NLE) is a rare, passively acquired autoimmune disease, caused by maternal autoantibodies. Characteristic clinical features of NLE are transient rash and congenital heart block (CHB), but also hematological abnormalities and hepatobiliary dysfunction may occur. Complications to the transient dermatitis are rarely described. We describe two patients with NLE and cutaneous manifestations. Both patients had involvement of the sun-protected genital skin and soles. New manifestations of NLE were gastrointestinal bleeding in one patient despite normal coagulation parameters, but with mucosal telangiectatic lesions found on sigmoidoscopy. In addition, one patient developed painful atrophy after plantar dermatitis on follow-up with need of orthopedic footwear. CHB was not found. In conclusion, NLE may be complicated with sigmoidal telangiectasia with rectal bleeding and painful plantar atrophy.
authors: Department of Dermatology and Allergy Centre, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark. rlaur@hotmail.dk
authors: Rasa
authors: R
authors: Laurinaviciene
authors: Henrik Thybo
authors: HT
authors: Christesen
authors: Anette
authors: A
authors: Bygum
mesh_terms: D005076:Exanthema / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000151:congenital / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications; D012867:Skin / Q000473:pathology*