title: Infant Aphakia Treatment Study: effects of persistent fetal vasculature on outcome at 1 year of age.
abstract: BACKGROUND
  The Infant Aphakia Treatment Study is a randomized trial that compares the treatment of unilateral congenital cataract with primary intraocular lens (IOL) implantation versus aphakic contact lens (CLs). The purpose of this study was to compare the outcomes for infants with lens opacity associated with persistent fetal vasculature (PFV) to those without.
  
  
  METHODS
  Retrospective subgroup analysis of grating visual acuity at 1 year of age and adverse events up to 1 year after surgery in eyes identified intraoperatively as having evidence of mild PFV from the IATS.
  
  
  RESULTS
  Of 83 infants, 18 (22%: 11 CL, 7 IOL) had PFV. Median logMAR visual acuity was 0.88 for patients with PFV and 0.80 for patients without PFV (P = 0.46). One or more adverse events up to 1 year after surgery occurred in 12 infants (67%) with PFV and 30 infants (46%) without PFV (P = 0.18). The incidence of adverse events was significantly greater in patients with PFV compared with patients without PFV in the CL group (55% vs 20%, P = 0.049) but not in the IOL group (86% vs 71%, P = 0.65), possibly because all children receiving IOLs had greater rates of adverse events when compared with aphakic children (73% vs 29%, P < 0.001).
  
  
  CONCLUSIONS
  Aphakic infants with mild PFV treated with CL had a greater incidence of adverse events after lensectomy compared with children with other forms of unilateral congenital cataract; nevertheless, similar visual outcomes at 1 year after surgery were obtained.
authors: Vanderbilt University School of Medicine, Nashville, TN, USA. david.morrison.1@vanderbilt.edu
authors: David G
authors: DG
authors: Morrison
authors: M Edward
authors: ME
authors: Wilson
authors: Rupal H
authors: RH
authors: Trivedi
authors: Scott R
authors: SR
authors: Lambert
authors: Michael J
authors: MJ
authors: Lynn
mesh_terms: D001036:Aphakia, Postcataract / Q000601:surgery*; D002386:Cataract / Q000150:complications / Q000151:congenital / Q000628:therapy*; D002387:Cataract Extraction / Q000009:adverse effects*; D003261:Contact Lenses / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D054514:Persistent Hyperplastic Primary Vitreous / Q000150:complications*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome