title: Planar cell polarity signaling pathway in congenital heart diseases.
abstract: Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and cardiogenesis in vertebrates, has been shown to play multiple roles during cardiac differentiation and development. The disrupted function of PCP signaling is connected to some CHDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of CHD.
authors: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors: Gang
authors: G
authors: Wu
authors: Jiao
authors: J
authors: Ge
authors: Xupei
authors: X
authors: Huang
authors: Yimin
authors: Y
authors: Hua
authors: Dezhi
authors: D
authors: Mu
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000235:genetics*; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000235:genetics; D054262:Gastrulation / Q000235:genetics*; D006321:Heart / Q000254:growth & development*; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D060449:Wnt Signaling Pathway