title: Angiogenesis in head and neck cancer: a review of the literature.
abstract: Angiogenesis is a necessary process for tumor growth, progression and diffusion. In the last years many efforts have been made to understand the mechanisms necessary to the formation of new vessels in tumor tissue and how to integrate these findings in the treatment of different type of cancer. Thanks to these studies there are today many anti-angiogenic drugs with established activity in cancer and approved in clinical practice. Head and neck cancer is a common tumor worldwide that often has advanced stage at diagnosis and poor prognosis. Angiogenesis has a well recognized role in head and neck cancer progression and resistance to drugs and radiotherapy and many clinical trials has been conducted with antiangiogenic agents in this disease, even if they often showed limited efficacy. In this review we summarize the main trials published about angiogenesis in head and neck cancer with particular attention to factors involved in this process and the available data on the efficacy of treatment with anti-angiogenic agents in this disease.
authors: Division of Medical Oncology, A.O. San Paolo Via di Rudinì 8, 20122 Milan, Italy.
authors: Codecà
authors: C
authors: Carla
authors: Ferrari
authors: F
authors: Daris
authors: Bertuzzi
authors: B
authors: Cecilia
authors: Broggio
authors: B
authors: Francesca
authors: Crepaldi
authors: C
authors: Francesca
authors: Foa
authors: F
authors: Paolo