title: Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas.
abstract: OBJECTIVE
  Gliomas are a group of center nervous system tumors of glial origin. Most are characterized by diffuse infiltrative growth in the surrounding brain. Patients almost always ultimately die from their disease. The drastically increased knowledge about the molecular abnormalities, these are linked with tumor grade and patient prognosis. The aim of this study was to examine the role of KIF2C and AURKB as prognostic factors in gliomas.
  
  
  METHODS
  A total 40 tumor samples and 6 normal brain tissue samples were collected. Biomarker KIF2C and AURKB were tested by qRT-PCR. Using Western blot validate the results.
  
  
  RESULTS
  We found that KIF2C and AURKB genes were higher expression in glioma samples when were compared with normal brain tissues. KIF2C and AURKB expression were associated with histopathological grades. We found that KIF2C as a potential independent prognostic marker for patient with glioma by Cox analysis.
  
  
  CONCLUSIONS
  The expression level of KIF2C mRNA could be a potential independent marker to evaluate patient prognosis.
authors: Department of Neurosurgery of the First Clinical Hospital, Jilin University, China. lbie@uci.edu
authors: Li
authors: L
authors: Bie
authors: Gang
authors: G
authors: Zhao
authors: Yin-ping
authors: YP
authors: Wang
authors: Bo
authors: B
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064107:Aurora Kinase B; D064127:Aurora Kinases; D014408:Biomarkers, Tumor / Q000235:genetics; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000235:genetics* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005910:Glioma / Q000235:genetics* / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000235:genetics; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D012313:RNA / Q000096:biosynthesis / Q000302:isolation & purification; D060888:Real-Time Polymerase Chain Reaction; D016019:Survival Analysis; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; C091489:KIF2C protein, human; D019394:Ki-67 Antigen; D012313:RNA; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D016547:Kinesins