title: Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG).
abstract: Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based "Treviso Longeva"--TRELONG Study from Italy (n = 668, age range 70-105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose-response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.
authors: Department of Neuroscience, "Mario Negri" Institute for Pharmacological Research, via La Masa, Milan, Italy. diego.albani@marionegri.it
authors: Diego
authors: D
authors: Albani
authors: Stefano
authors: S
authors: Mazzuco
authors: Letizia
authors: L
authors: Polito
authors: Sara
authors: S
authors: Batelli
authors: Gloria
authors: G
authors: Biella
authors: Fausta
authors: F
authors: Ongaro
authors: Deborah R
authors: DR
authors: Gustafson
authors: Piero
authors: P
authors: Antuono
authors: Gianbattista
authors: G
authors: Gajo
authors: Elisabetta
authors: E
authors: Durante
authors: Livio
authors: L
authors: Caberlotto
authors: Andrea
authors: A
authors: Zanardo
authors: Marinella
authors: M
authors: Siculi
authors: Maurizio
authors: M
authors: Gallucci
authors: Gianluigi
authors: G
authors: Forloni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006720:Homozygote; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics; D007558:Italy / Q000453:epidemiology; D008136:Longevity / Q000235:genetics* / Q000502:physiology; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D012737:Sex Factors
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1