title: Narrow-band imaging flexible cystoscopy in the detection of clinically unconfirmed positive urine cytology.
abstract: BACKGROUND
  The objective of this study was to investigate the value of narrow-band imaging (NBI) cystoscopy in the detection of patients with positive voided urine cytology (VUC) who have no evidence of disease after standard initial investigations.
  
  
  METHODS
  Between February 2009 and December 2010, 12 patients with positive or suspicious VUC but no regular endoscopic evidence of cancer were investigated with NBI flexible cystoscopy. All the specimens were biopsied both under NBI and white light imaging (WLI). Random biopsies of bladder and prostatic urethra were performed in cases without suspect lesions.
  
  
  RESULTS
  Fourteen NBI cystoscopies were carried out in 12 patients. Non-muscle-invasive bladder cancer was diagnosed in 5 of 12 (42%) patients on the first NBI. One patient had carcinoma in situ diagnosed on repeat NBI 3 months later. The sensitivity and specificity in diagnosing unconfirmed positive VUC was 78 and 91% for NBI vs. 50 and 80% for WLI.
  
  
  CONCLUSIONS
  NBI cystoscopy significantly improves detection of unconfirmed positive VUC over WLI. It should be carried out early in the investigation of such patients before random biopsies and ureteroscopy.
authors: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Yi-Ping
authors: YP
authors: Zhu
authors: Yi-Jun
authors: YJ
authors: Shen
authors: Ding-Wei
authors: DW
authors: Ye
authors: Chao-Fu
authors: CF
authors: Wang
authors: Xu-Dong
authors: XD
authors: Yao
authors: Shi-Lin
authors: SL
authors: Zhang
authors: Bo
authors: B
authors: Dai
authors: Hai-Liang
authors: HL
authors: Zhang
authors: Guo-Hai
authors: GH
authors: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology* / Q000652:urine*; D002681:China; D003558:Cystoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000652:urine*; D014556:Urine / Q000166:cytology*; D019459:Urothelium / Q000473:pathology