title: [Intensity-modulated radiotherapy and involved-node concept in patients with Hodgkin lymphoma: experience of the Gustave-Roussy Institute].
abstract: OBJECTIVE
  To assess the clinical outcome of the involved-node radiotherapy concept with the use of intensity modulated radiotherapy (IMRT) in patients with localized supradiaphragmatic Hodgkin lymphoma.
  
  
  METHODS
  Patients with early-stage supradiaphragmatic Hodgkin lymphoma were treated with chemotherapy prior to irradiation. Radiation treatments were delivered using the involved-node radiotherapy (INRT) concept according to the EORTC guidelines. Intensity modulated radiotherapy was performed free-breathing.
  
  
  RESULTS
  Forty-seven patients with Hodgkin lymphoma (44 patients with primary Hodgkin lymphoma and three patients with recurrent disease) entered the study from January 2003 to December 2010. The median age was 31 years (range 17 to 62). Thirty patients had stage I-IIA, 14 had stage I-IIB disease and three had relapse. Forty-two patients received three to six cycles of adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). The median radiation dose to patients was 36 Gy (range: 20-40). Protection of various organs at risk was satisfactory. The median follow-up was 57.4 months (range: 5.4-94.3). For patients with primary Hodgkin lymphoma, the 5-year survival and 5-year progression-free survival rates were 96% (95% confidence interval: 80-99) and 92% (95% confidence interval: 78-97), respectively. None of the three patients with recurrent disease has relapsed. Recurrences occurred in three patients: one was in-field relapse and two were visceral recurrences. Grade 3 acute lung toxicity (transient pneumonitis) occurred in one case.
  
  
  CONCLUSIONS
  Our results suggest that patients with localized Hodgkin lymphoma can be safely and efficiently treated using the involved node irradiation concept and intensity modulated irradiation.
authors: Département de Radiothérapie, Institut de Cancérologie Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif, France. amaury.paumier@igr.fr
authors: A
authors: A
authors: Paumier
authors: W
authors: W
authors: Khodari
authors: A
authors: A
authors: Beaudre
authors: M
authors: M
authors: Ghalibafian
authors: P
authors: P
authors: Blanchard
authors: H
authors: H
authors: Al Hamokles
authors: M
authors: M
authors: Bhari
authors: N
authors: N
authors: Lessard
authors: T
authors: T
authors: Girinsky
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006268:Health Facilities; D006689:Hodgkin Disease / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D055815:Young Adult