title: Paclitaxel-induced peripheral neuropathy in patients receiving adjuvant chemotherapy for breast cancer.
abstract: BACKGROUND
  The long-term outcomes and risk factors of paclitaxel-induced peripheral neuropathy (PIPN) have not yet been fully elucidated.
  
  
  METHODS
  We identified 219 breast cancer patients who received paclitaxel as adjuvant chemotherapy between 2002 and 2009. We retrospectively analyzed the incidence, time to onset, duration, and risk factors for PIPN by chart review.
  
  
  RESULTS
  Of the 219 patients, 212 developed PIPN (97%) during a median follow-up time of 57 months (range 5.3-95.5). Median time to PIPN onset was 21 days (range 11-101) for the entire patient population: 35 days (range 14-77) for weekly administration and 21 days (range 11-101) for tri-weekly administration. PIPN caused termination of paclitaxel treatment in 7 patients (4%). Median duration of PIPN was 727 days (range 14-2621 days). PIPN persisted in 64 and 41% of patients at 1 and 3 years after initiating paclitaxel, respectively. Age ≥60 years and severity of PIPN were significantly associated with PIPN duration.
  
  
  CONCLUSIONS
  PIPN persists longer in older patients and in those who experience severe neuropathy. Further studies to identify the risk factors for PIPN are warranted.
authors: Department of Breast Oncology and Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors: Yuko
authors: Y
authors: Tanabe
authors: Kenji
authors: K
authors: Hashimoto
authors: Chikako
authors: C
authors: Shimizu
authors: Akihiro
authors: A
authors: Hirakawa
authors: Kenichi
authors: K
authors: Harano
authors: Mayu
authors: M
authors: Yunokawa
authors: Kan
authors: K
authors: Yonemori
authors: Noriyuki
authors: N
authors: Katsumata
authors: Kenji
authors: K
authors: Tamura
authors: Masashi
authors: M
authors: Ando
authors: Takayuki
authors: T
authors: Kinoshita
authors: Yasuhiro
authors: Y
authors: Fujiwara
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage* / Q000009:adverse effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D017239:Paclitaxel