title: Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth.
abstract: To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: -0.06±0.75 versus CG: 0.20±0.64 versus GG: 0.07±0.78; P=1.65 × 10(-3), adjusted P=9.90 × 10(-3)). However, this difference was not significant after adjustment for cord blood adiponectin (P=0.04, adjusted P=0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1±20.2 versus CG: 44.3±26.1 versus GG: 54.1±36.7 μg ml(-1), P=2.80 × 10(-9), adjusted P=1.68 × 10(-8)). This association remained after adjustment for birth weight s.d. score (P=6.63 × 10(-8), adjusted P=3.98 × 10(-7)). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.
authors: Department of Pediatrics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
authors: Makoto
authors: M
authors: Saito
authors: Tomohiro
authors: T
authors: Kamoda
authors: Kazunori
authors: K
authors: Nishimura
authors: Yayoi
authors: Y
authors: Miyazono
authors: Yu
authors: Y
authors: Kanai
authors: Yoshiaki
authors: Y
authors: Kato
authors: Atsushi
authors: A
authors: Iwabuchi
authors: Hiroko
authors: H
authors: Fukushima
authors: Hiromi
authors: H
authors: Hamada
authors: Tadao
authors: T
authors: Arinami
authors: Ryo
authors: R
authors: Sumazaki
authors: Emiko
authors: E
authors: Noguchi
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D001724:Birth Weight / Q000235:genetics; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D047109:Fetal Development / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D052242:Adiponectin