title: A novel and versatile computational tool to model translation.
abstract: BACKGROUND
  Much is now known about the mechanistic details of gene translation. There are also rapid advances in high-throughput technologies to determine quantitative aspects of the system. As a consequence-realistic and system-wide simulation models of translation are now feasible. Such models are also needed as devices to integrate a large volume of highly fragmented data known about translation. Software: In this application note, we present a novel, highly efficient software tool to model translation. The tool represents the main aspects of translation. Features include a representation of exhaustible tRNA pools, ribosome-ribosome interactions and differential initiation rates for different mRNA species. The tool is written in Java, and is hence portable and can be parameterized for any organism.
  
  
  BACKGROUND
  The model can be obtained from the authors or directly downloaded from the authors' home-page (http://goo.gl/JUWvI).
authors: School of Computing, University of Kent, Kent CT2 7NF, UK. d.f.chu@kent.ac.uk
authors: Dominique
authors: D
authors: Chu
authors: Nicolae
authors: N
authors: Zabet
authors: Tobias
authors: T
authors: von der Haar
mesh_terms: D003062:Codon; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D012984:Software
chemical_list: D003062:Codon; D012333:RNA, Messenger; D012343:RNA, Transfer