title: Impact of lipid profile and high blood pressure on endothelial damage.
abstract: BACKGROUND
  Endothelial damage is an early component of atherosclerosis; however, the impact of cardiovascular risk factors on endothelial function is not clearly understood. We investigated the impact of lipid profiles and high blood pressure on damage.
  
  
  OBJECTIVE
  Japanese male outpatients with grade I or II hypertension, along with gender and age-matched normotensive subjects (both n = 25), were enrolled. Subjects with severe cardiovascular risk factors or illness or those taking medications were excluded. Blood was sampled for laboratory analysis and endothelial function was assessed by flow-mediated dilation (FMD).
  
  
  RESULTS
  Total cholesterol to high-density lipoprotein cholesterol ratio (total-C/HDL-C) was inversely correlated with the FMD value and positively correlated with both malondialdehyde-modified low-density lipoprotein and high-sensitivity C-reactive protein values. Stepwise regression analysis revealed total-C/HDL-C and systolic blood pressure were significant determinants of FMD. Hypertensive subjects had lower FMD values and similar lipid profiles to normotensive subjects. Grouping subjects according to total-C/HDL-C levels showed that those with high values had lower FMD values. Hypertensive subjects with low total-C/HDL-C had similar endothelial index values to those in normotensive subjects with high total-C/HDL-C. Logistic regression indicated hypertension and high total-C/HDL-C were significantly associated with low FMD values.
  
  
  CONCLUSIONS
  Impaired endothelial function was associated with increased total-C/HDL-C values, possibly as the result of increased vascular oxidative stress and inflammation. In the early stages of atherosclerosis, the impact of both total-C/HDL-C and BP may be similar in terms of endothelial damage.
authors: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. tomosugi@med.nagoya-cu.ac.jp
authors: Tomonori
authors: T
authors: Sugiura
authors: Yasuaki
authors: Y
authors: Dohi
authors: Sumiyo
authors: S
authors: Yamashita
authors: Koji
authors: K
authors: Yamamoto
authors: Yoshimasa
authors: Y
authors: Wakamatsu
authors: Satoru
authors: S
authors: Tanaka
authors: Genjiro
authors: G
authors: Kimura
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D018836:Inflammation Mediators / Q000097:blood; D007564:Japan / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000031:analogs & derivatives* / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D014463:Ultrasonography; D014664:Vasodilation; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C569869:malondialdehyde-low density lipoprotein, human; D008315:Malondialdehyde; D002097:C-Reactive Protein; D002784:Cholesterol