title: The myeloperoxidase-463 G>A polymorphism influences risk of colorectal cancer in southern China: a case-control study.
abstract: OBJECTIVE
  Oxidative stress may be involved in colorectal carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). We hypothesized that the MPO -463 locus polymorphism might therefore contribute to genetic susceptibility to colorectal adenomas.
  
  
  METHODS
  RFLP-PCR analysis identified the MPO genotypes in 325 Chinese colorectal adenomas cases and 345 controls matched by age, sex, smoking status, and alcohol use. An epidemiological interview elicited detailed information on demographic data and lifestyle characteristics.
  
  
  RESULTS
  Individuals with a GA/AA genotype had a significantly lower risk of colorectal cancer (adjusted OR = 0.57, 95% CI, 0.41-0.79) than those with the GG genotype. On stratification analysis, the decreased risk was more pronounced among older subjects (adjusted OR = 0.56, 95% CI, 0.39-0.81), males (0.47, 0.33-0.68), smokers (0.54, 0.35-0.85), and ever-drinkers (0.44, 0.27-0.71).
  
  
  CONCLUSIONS
  For a similar level of exposure to established carcinogens, individuals with MPO A-allele genotypes appear to have a reduced risk of colorectal adenomas in southern Chinese population, especially among older subjects, men, smokers, and ever-drinkers.
authors: Department of Chemotherapy, The Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, China.
authors: Ying
authors: Y
authors: Li
authors: Yuan
authors: Y
authors: Qin
authors: Mei-Lin
authors: ML
authors: Wang
authors: Huan-Feng
authors: HF
authors: Zhu
authors: Xin-En
authors: XE
authors: Huang
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017382:Reactive Oxygen Species; D012307:Risk Factors
chemical_list: D017382:Reactive Oxygen Species; D009195:Peroxidase