title: DNA methylation as a biomarker for neuropsychiatric diseases.
abstract: ABSTRACT   DNA methylation, which has been investigated extensively recently, has been studied in various human diseases, including cancer, and the analysis of DNA methylation has provided useful biomarkers for diagnosing cancer, monitoring treatment, and predicting the prognosis of cancer. Recently, aberrant DNA methylation has been reported in various neuropsychiatric diseases in both postmortem brains and peripheral blood cells. This review summarizes the current evidence on aberrant DNA methylation in peripheral blood cells from patients with neurodevelopmental, neurodegenerative, and psychiatric disorders, and we propose that DNA methylation could be a novel biomarker for these disorders.
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors: Sanxi
authors: S
authors: Ai
authors: Lu
authors: L
authors: Shen
authors: Jifeng
authors: J
authors: Guo
authors: Xiang
authors: X
authors: Feng
authors: Beisha
authors: B
authors: Tang
mesh_terms: D000328:Adult; D015415:Biomarkers; D001773:Blood Cells / Q000502:physiology; D002648:Child; D019175:DNA Methylation; D002658:Developmental Disabilities / Q000235:genetics; D057890:Epigenomics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D009422:Nervous System Diseases / Q000235:genetics*; D019636:Neurodegenerative Diseases / Q000235:genetics
chemical_list: D015415:Biomarkers