title: Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men.
abstract: OBJECTIVE
  To investigate the association between SEPTIN12 gene variants and the risk of azoospermia caused by meiotic arrest.
  
  
  METHODS
  Mutational analysis of the SEPTIN12 gene was performed using DNA from 30 Japanese patients with azoospermia by meiotic arrest and 140 fertile male controls.
  
  
  RESULTS
  The frequencies of the c.204G>C (Gln38His) allele and the CC genotype were significantly higher in patients than in fertile controls (p < 0.05).
  
  
  CONCLUSIONS
  The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest.
authors: Department of Obstetrics and Gynecology, Asahikawa Medical University, Midorigaokahigashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan. toshim@asahikawa-med.ac.jp
authors: Toshinobu
authors: T
authors: Miyamoto
authors: Akira
authors: A
authors: Tsujimura
authors: Yasushi
authors: Y
authors: Miyagawa
authors: Eitetsu
authors: E
authors: Koh
authors: Mikio
authors: M
authors: Namiki
authors: Michiharu
authors: M
authors: Horikawa
authors: Yasuaki
authors: Y
authors: Saijo
authors: Kazuo
authors: K
authors: Sengoku
mesh_terms: D000483:Alleles; D053713:Azoospermia / Q000235:genetics*; D059447:Cell Cycle Checkpoints / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008297:Male; D008540:Meiosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058112:Septins / Q000235:genetics*
chemical_list: C502729:SEPTIN12 protein, human; D058112:Septins