title: [Role of the blood-brain barrier in Alzheimer's disease].
abstract: The blood-brain barrier (BBB), which isolates the brain from the whole body, restricts exchanges between the brain and the peripheral compartments. Several studies highlight the importance of this barrier in neurodegenerative diseases such as Alzheimer's disease (AD). This pathology is characterized by an abnormal accumulation and aggregation of Aβ peptides which contribute to the neurodegenerative processes and the BBB seems to play a key role for the brain Aβ peptides metabolism. This review focuses on recent data demonstrating the important role of the BBB in AD, suggesting that this barrier is a possible new therapeutic target in this disease.
authors: Université d'Artois, Université Lille-Nord de France, Laboratoire de physiopathologie de la barrière hématoencéphalique, F-62300 Lens, France. fabien.gosselet@univ-artois.fr
authors: Fabien
authors: F
authors: Gosselet
authors: Pietra
authors: P
authors: Candela
authors: Roméo
authors: R
authors: Cecchelli
authors: Laurence
authors: L
authors: Fenart
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D002463:Cell Membrane Permeability / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008954:Models, Biological; D020286:Pericytes / Q000378:metabolism / Q000502:physiology; D021381:Protein Transport / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides