title: Retrobulbar hemodynamic effects of nipradilol in normal and normal-tension glaucoma eyes.
abstract: Purpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patients. Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG). Results. In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week. There were no significant changes in the placebo-treated eyes. In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks. Conclusion. Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes.
authors: Department of Ophthalmology, Mie University School of Medicine, Mie 514-8507, Japan.
authors: Mitsushi
authors: M
authors: Fukukita
authors: Masashi
authors: M
authors: Ido
authors: Syunsuke
authors: S
authors: Osawa
authors: Mikio
authors: M
authors: Sasoh
authors: Motoyasu
authors: M
authors: Furuta
authors: Kunio
authors: K
authors: Ito
authors: Masahiko
authors: M
authors: Sugimoto
authors: Yukitaka
authors: Y
authors: Uji