title: [Expression and clinical significance of serum VEGF and bFGF in children with acute leukemia].
abstract: OBJECTIVE
  To study the expression and clinical significance of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in children with acute leukemia (AL).
  
  
  METHODS
  The serum VEGF and bFGF level before chemotherapy from 40 cases of children with newly diagnosed AL, after 1 course of treatment from from 37 cases of children with complete remission (CR) and no- remission(NR) , and 40 cases of healthy children (control group) were detected by ELISA technology.
  
  
  RESULTS
  Before treatment, the serum VEGF and bF-GF level of the AL group and different types of AL were significantly higher than the control group(P<0.05), while the serum VEGF and bFGF level were no significant difference between the different types of AL ( P > 0.05). Before treatment, the serum VEGF and bFGF level were no significant difference between the AL CR and NR children; After treatment, the serum VEGF and bFGF level of CR children decreased significantly, compared with the prior-treatment and NR children the different was significant ( P < 0. 05); While the serum VEGF and bFGF level of NR children were no significant difference between prior-treatment and post-treatment.
  
  
  CONCLUSIONS
  The serum VEGF and bFGF level have high expression in children with AL, the serum VEGF and bFGF level can be used as indicators of AL efficacy, and are correlation with the prognosis of children with AL.
authors: Department of Pediatrics, People's Hospital of Hechuan District, Chongqing 401520, China.
authors: Huo
authors: H
authors: Hong-bing
authors: Xie
authors: X
authors: Wen-yi
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2