title: Hereditary thrombophilia, anti-beta2 glycoprotein 1 IgM, and anti-annexin V antibodies in recurrent pregnancy loss.
abstract: OBJECTIVE
  We investigated the beta2-glycoprotein I and anti-annexin V antibodies as anti-phospholipid-cofactor antibodies; and factor V G1691A Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations as hereditary thrombophilia in recurrent pregnancy losses (RPL).
  
  
  METHODS
  Study group consisted of 84 women with recurrent pregnancy loss and control group consisted of 84 women having at least one live birth.
  
  
  RESULTS
  Methylenetetrahydrofolate reductase C677T homozygous mutation was detected in 28.5% of the study group and in 14.2% of the controls, and the difference was highly significant (P < 0.001). Heterozygous mutation of this gene was found in 64.3% of the study population and in 38.1% of the controls, and difference in heterozygous mutation frequency was also significant (P < 0.001). Both homozygous and heterozygous mutations of PT G20210A and factor V G1691A were not different between the groups. There was no significant difference in anti-annexin V levels and anti-beta2-gp 1 levels of the groups.
  
  
  CONCLUSIONS
  We concluded that both homozygous and heterozygous mutations of MTHFR C677T were related with RPL in Caucasian women.
authors: Obstetrics and Gynecology, Istanbul University, Istanbul, Turkey.
authors: Suat
authors: S
authors: Karata
authors: Yavuz
authors: Y
authors: Aydin
authors: Fahri
authors: F
authors: Ocer
authors: Aysenur
authors: A
authors: Buyru
authors: Huriye
authors: H
authors: Balci
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D011247:Pregnancy
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)