title: The CD4C/HIV(Nef)transgenic model of AIDS.
abstract: CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.
authors: Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada. paul.jolicoeur@ircm.qc.ca
authors: Paul
authors: P
authors: Jolicoeur
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D015497:HIV-1 / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000502:physiology*
chemical_list: D054311:nef Gene Products, Human Immunodeficiency Virus