title: Surfactant therapy for maternal blood aspiration: an unusual cause of neonatal respiratory distress syndrome.
abstract: Surfactant replacement therapy is the main treatment of neonatal respiratory distress syndrome. However, surfactant therapy has been shown to be effective in the treatment of other diseases causing neonatal respiratory diseases such as pulmonary hemorrhage, meconium aspiration syndrome, pneumonia/sepsis, pulmonary edema or acute lung injury resulting a secondary surfactant deficiency (SSD). Rarely, as like as in the present patient, exogenous blood aspiration such as breast milk or formula aspiration may lead to SSD. Blood in alveolus leads to a significant biochemical and functional disturbance of the surfactant system and inhibits surfactant production. Here, the authors report a preterm infant of 33 wk gestational age with secondary surfactant deficiency due to maternal blood aspiration because of abruptio placentae. She was received two courses of beractant, a natural bovine surfactant, therapy in 24 h. She was extubated on second day and did not require oxygen on 4(th) day. To the authors' knowledge, this is the first reported case of SSD due to maternal blood aspiration treated with surfactant. In conditions such as abruptio placentae, infant should be protected from blood aspiration and if respiratory distress occurs, surfactant inhibition and need for surfactant administration should be considered.
authors: Division of Neonatology, Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, 06230 Cebeci, Ankara, Turkey. istemihancelik@gmail.com
authors: Istemi Han
authors: IH
authors: Celik
authors: Gamze
authors: G
authors: Demirel
authors: Fuat Emre
authors: FE
authors: Canpolat
authors: Omer
authors: O
authors: Erdeve
authors: Ugur
authors: U
authors: Dilmen
mesh_terms: D000037:Abruptio Placentae; D001688:Biological Products / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008471:Meconium Aspiration Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D011650:Pulmonary Alveoli / Q000473:pathology*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D011663:Pulmonary Surfactants; C072197:beractant