title: Coumarin incorporated triazoles: a new class of anticonvulsants.
abstract: A series of coumarin incorporated 1,2,4- triazole compounds (1-14) were evaluated for their possible anticonvulsant and neurotoxic properties, log P values, pharmacophoric mapping and three dimensional structure analysis. Compound (6) with para-fluoro substitution showed significant anticonvulsant activity.
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box. 2457, Riyadh 11451, Kingdom of Saudi Arabia. mashooqbhat@rediffmail.com
authors: Mashooq A
authors: MA
authors: Bhat
authors: Mohammed A
authors: MA
authors: Al-Omar
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D003374:Coumarins / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004558:Electric Stimulation; D007274:Injections, Intraperitoneal; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000209:etiology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D003374:Coumarins; D014230:Triazoles; C045575:1,2,4-triazole; D010433:Pentylenetetrazole