title: Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson's disease.
abstract: BACKGROUND
  In Parkinson's disease, sleep disturbance is a common occurrence.
  
  
  METHODS
  We evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ± 9.8 years; disease duration, 12.3 ± 2.7 years) before and after subthalamic nucleus deep brain stimulation using the Parkinson's disease sleep scale and polysomnography.
  
  
  RESULTS
  Their total sleep scale scores and daytime sleepiness subscale scores significantly improved after subthalamic nucleus-deep brain stimulation. The novel findings from this study significantly increased normal rapid eye movement sleep, and decreased abnormal rapid eye movement sleep without atonia after deep brain stimulation in patients with Parkinson's disease. The improved total sleep scale score correlated with decreased wakefulness after sleep onset. Moreover, improved daytime sleepiness correlated with increased normal rapid eye movement sleep time. Sleep improvement did not significantly correlate with resolution of motor complication or reduced dopaminergic dosages.
  
  
  CONCLUSIONS
  Subthalamic nucleus-deep brain stimulation may have beneficial effects on sleep disturbance in advanced Parkinson's disease by restoring sleep architecture and normal rapid eye movement sleep.
authors: Department of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka, Japan.
authors: Namiko
authors: N
authors: Nishida
authors: Tokiko
authors: T
authors: Murakami
authors: Kunihiro
authors: K
authors: Kadoh
authors: Rie
authors: R
authors: Tohge
authors: Miki
authors: M
authors: Yamanegi
authors: Hidemoto
authors: H
authors: Saiki
authors: Keita
authors: K
authors: Ueda
authors: Sadayuki
authors: S
authors: Matsumoto
authors: Masatsune
authors: M
authors: Ishikawa
authors: Jun A
authors: JA
authors: Takahashi
authors: Hiroki
authors: H
authors: Toda
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D017286:Polysomnography; D020923:REM Sleep Parasomnias / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000502:physiology* / Q000601:surgery; D016896:Treatment Outcome