title: Histopathological safety evaluation of newly-developed MgO sealer.
abstract: We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.
authors: Hard Tissue Pathology Unit, Matsumoto Dental University, Graduate School of Oral Medicine, Shiojiri, Japan.
authors: K
authors: K
authors: Nakano
authors: M
authors: M
authors: Tomida
authors: M
authors: M
authors: Sato
authors: S
authors: S
authors: Matsuura
authors: A
authors: A
authors: Yamamoto
authors: E
authors: E
authors: Kasahara
authors: T
authors: T
authors: Kawakami
mesh_terms: D000818:Animals; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D008277:Magnesium Oxide / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D051379:Mice; D008815:Mice, Inbred Strains; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000494:pharmacology*; D040521:Subcutaneous Tissue / Q000187:drug effects
chemical_list: D012387:Root Canal Filling Materials; D008277:Magnesium Oxide