title: A case of severe oral self-injurious Tourette's syndrome alleviated by pregabalin.
abstract: Self-injurious behavior (SIB) associated with Tourette's syndrome (TS) is a severe neuropsychiatric condition that causes significant distress and can impair social functioning. The current treatment options for the condition include pharmacological, physical and psychosocial interventions. However, given the need for more effective interventions, especially for those patients who are unresponsive and/or intolerant to standard medications, further exploration of novel treatments is imperative. In this report, we present a case of SIB-TS that was successfully treated with pregabalin. The patient received 1-year of follow-up and was noted to have considerable improvement in symptoms. Although rigorous controlled studies are required, based on our case study, pregabalin may be a potential treatment option in some cases of SIB with TS.
authors: Scienze della Formazione, University of Catania, Catania, Italy. dott.fornaro@gmail.com
authors: Michele
authors: M
authors: Fornaro
authors: Angelo Giovanni Icro
authors: AG
authors: Maremmani
authors: Maria Giovanna
authors: MG
authors: Colicchio
authors: Anna
authors: A
authors: Romano
authors: Stefania
authors: S
authors: Fornaro
authors: Salvatore
authors: S
authors: Rizzato
authors: Giovanni
authors: G
authors: Ciampa
authors: Salvatore
authors: S
authors: Colicchio
authors: Liliana
authors: L
authors: Dell'Osso
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000293:injuries; D000069583:Pregabalin; D016728:Self-Injurious Behavior / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D005879:Tourette Syndrome / Q000150:complications*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid