title: Population-based human papillomavirus 16, 18, 6 and 11 DNA positivity and seropositivity in Chinese women.
abstract: To optimize HPV vaccination implementation at the population-level in China, data are needed on age-specific HPV 16, 18, 6 and 11 prevalence. This cross-sectional, population-based study evaluated the age- and type-specific HPV 16, 18, 6 and 11 prevalence of DNA and serum antibodies among women in China. From July 2006 to April 2007, 17-54 year old women from three rural provinces (Xinjiang, Shanxi and Henan) and two cities (Beijing and Shanghai) provided cervical exfoliated cells for HPV DNA and liquid-based cervical cytology (SurePath). High- and low-risk HPV types were detected with HC-II (Qiagen), with genotyping of HPV-positive samples using Linear Array (Roche). HPV 16, 18, 6 and 11 serum antibodies were detected using a Luminex-based, competitive immunoassay (Merck). A total of 4,206 women with DNA and serum antibody results were included. HPV 16 DNA prevalence peaked in women aged 30-34 (4.2%) and 45-49 yr (3.8%), while HPV 18 DNA prevalence peaked at ages 40-44 yr (1.3%). Most women were dually DNA and serum antibody negative: HPV 16 (92.2%), 18 (97.2%), HPV 16 and 18 (90.2%), 6 (92.0%), 11 (96.6%), 6 and 11(89.9%) and HPV 16, 18, 6 and 11 (82.5%). Future national HPV vaccination programs in China should target younger women due to increased exposure to HPV types 16, 18, 6 and 11 with increasing age. Cumulative exposure of HPV may be underreported in this population, as cross-sectional data do not accurately reflect exposure to HPV infections over time.
authors: Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC 27599, USA. JenniferS@unc.edu
authors: Jennifer S
authors: JS
authors: Smith
authors: Adam K
authors: AK
authors: Lewkowitz
authors: You-Lin
authors: YL
authors: Qiao
authors: Jia
authors: J
authors: Ji
authors: Shangying
authors: S
authors: Hu
authors: Wen
authors: W
authors: Chen
authors: Rong
authors: R
authors: Zhang
authors: Kai Li
authors: KL
authors: Liaw
authors: Mark
authors: M
authors: Esser
authors: Frank J
authors: FJ
authors: Taddeo
authors: Robert G
authors: RG
authors: Pretorius
authors: Jerome L
authors: JL
authors: Belinson
mesh_terms: D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D000914:Antibodies, Viral / Q000097:blood*; D002681:China; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000097:blood* / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral