title: Impact of swine influenza and quarantine measures on patients and households during the H1N1/09 pandemic.
abstract: OBJECTIVE
  To assess the secondary attack rates (SAR) and impact of the 2009 H1N1 epidemic in Melbourne, Victoria, Australia, and the measures implemented to control household transmission.
  
  
  METHODS
  Patients with polymerase chain reaction-confirmed influenza A and pandemic H1N1 (pH1N1) were identified from hospital and microbiology laboratory records and asked to take part in a retrospective survey. Information obtained included: the constellation of symptoms, contact history, secondary infection, and household information, including adherence and attitudes towards quarantine measures.
  
  
  RESULTS
  The overall SAR of pH1N1 index patients was 30.6%, but a significantly lower SAR was noted with oseltamivir treatment (36.6% vs 22.8%, p < 0.05). The greatest reduction in SAR was observed when index patients aged 0-4 y received oseltamivir (83.3% vs 22.2%, p < 0.01). Quarantine was requested of 65.8% of patients and 92.8% self-reported adhering to recommendations. pH1N1 index patients, the number of median days bed-bound is 2.5 days, being unable or too sick to work for a median of 5.0 days, and lost a median of 7.0 days of work for reasons related to an influenza-like illness.
  
  
  CONCLUSIONS
  The pH1N1 influenza pandemic had a significant clinical impact on households. Public health interventions such as oseltamivir treatment of index cases were beneficial in reducing secondary attack rates, whilst quarantine measures were found to have high rates of self-reported compliance, understanding, and acceptability.
authors: Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.
authors: Benjamin
authors: B
authors: Teh
authors: Karen
authors: K
authors: Olsen
authors: Jim
authors: J
authors: Black
authors: Allen C
authors: AC
authors: Cheng
authors: Craig
authors: C
authors: Aboltins
authors: Kirstin
authors: K
authors: Bull
authors: Paul D R
authors: PD
authors: Johnson
authors: M Lindsay
authors: ML
authors: Grayson
authors: Joseph
authors: J
authors: Torresi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D011790:Quarantine / Q000523:psychology / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires