title: The presence of 3-hydroxy oxylipins in pathogenic microbes.
abstract: There is a sufficient body of work documenting the distribution of 3-hydroxy oxylipins in microbes. However, there is limited information on the role of these compounds in microbial pathogenesis. When derived from mammalian cells, these compounds regulate patho-biological processes, thus an understanding of 3-hydroxy oxylipin function and metabolism could prove important in shedding light on how these compounds mediate cellular pathology and physiology. This could present 3-hydroxy oxylipin biosynthetic pathways as targets for drug development. In this minireview, we interrogate the relevant yeast and bacterial 3-hydroxy oxylipin literature in order to appreciate how these compounds may influence the inflammatory response leading to disease development.
authors: Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, 205 Nelson Mandela Drive, Park West, Bloemfontein 9301, South Africa. sebolaiom@ufs.ac.za
authors: Olihile M
authors: OM
authors: Sebolai
authors: Carolina H
authors: CH
authors: Pohl
authors: Lodewyk J F
authors: LJ
authors: Kock
authors: Vishnu
authors: V
authors: Chaturvedi
authors: Maurizio
authors: M
authors: del Poeta
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D054883:Oxylipins / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D054883:Oxylipins