title: The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols.
abstract: A synthetic route towards a number of novel IBiox N-heterocyclic carbene (NHC) ligands has been developed. The resulting ligands have restricted flexibility and high steric demand. Preliminary studies have shown these ligands to give high levels of asymmetric induction in the copper-free allylic alkylation of cinnamyl bromide.
authors: Department of Chemistry, Imperial College London, London, SW7 2AZ, United Kingdom.
authors: Jean-Noël
authors: JN
authors: Levy
authors: Christopher M
authors: CM
authors: Latham
authors: Loïc
authors: L
authors: Roisin
authors: Nadine
authors: N
authors: Kandziora
authors: Paolo
authors: P
authors: Di Fruscia
authors: Andrew J P
authors: AJ
authors: White
authors: Simon
authors: S
authors: Woodward
authors: Matthew J
authors: MJ
authors: Fuchter
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007189:Indans; D008024:Ligands; D010080:Oxazoles; C116915:aminoindanol; C030011:carbene; D008697:Methane