title: Follow-up study of variants of the GIGYF2 gene in Chinese patients  with Parkinson’s disease.
abstract: The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.
authors: Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
authors: Lei
authors: L
authors: Wang
authors: Ji-Feng
authors: JF
authors: Guo
authors: Wen-Wen
authors: WW
authors: Zhang
authors: Qian
authors: Q
authors: Xu
authors: Xing
authors: X
authors: Zuo
authors: Chang-He
authors: CH
authors: Shi
authors: Lin-Zi
authors: LZ
authors: Luo
authors: Jia
authors: J
authors: Liu
authors: Liang
authors: L
authors: Hu
authors: Ya-Cen
authors: YC
authors: Hu
authors: Xin-Xiang
authors: XX
authors: Yan
authors: Bei-Sha
authors: BS
authors: Tang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D002352:Carrier Proteins; C478016:GIGYF2 protein, human