title: Chemoselective aromatic C-H insertion of α-diazo-β-ketoesters catalyzed by dirhodium(II) carboxylates.
abstract: The ability of α-diazo-β-ketoesters bearing a substituent on the benzylic position to undergo aromatic C-H insertion is described. Good to excellent yields of the aromatic C-H insertion products were observed with Rh(2)(tpa)(4) or Rh(2)(esp)(2) catalysts. This is an attractive strategy to prepare tetralins carrying a methyl group on the benzylic position, a structural motif found in several types of natural products.
authors: Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, Iowa 52242, USA.
authors: Esdrey
authors: E
authors: Rodriguez-Cárdenas
authors: Rocío
authors: R
authors: Sabala
authors: Moisés
authors: M
authors: Romero-Ortega
authors: Aurelio
authors: A
authors: Ortiz
authors: Horacio F
authors: HF
authors: Olivo
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D002264:Carboxylic Acids; D004952:Esters; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium