title: Tissue-engineered airway: a regenerative solution.
abstract: The use of synthetic degradable or permanent polymers and biomaterials has not yet helped to achieve successful clinical whole-airway replacement. A novel, clinically successful approach involves tissue engineering (TE) replacement using three-dimensional biologic scaffolds composed of allogeneic extracellular scaffolds derived from nonautologous sources and recellularized with autologous stem cells or differentiated cells. In this paper, we discuss this novel approach and review information that can lead to a better understanding of stem cell recruitment and/or mobilization and site-specific tissue protection, which can be pharmacologically boosted in humans.
authors: Advanced Center of Translational Regenerative Medicine, Karolinska Institutet, Division of Ear, Nose, and Throat, University Hospital, Stockholm, Sweden.
authors: P
authors: P
authors: Jungebluth
authors: G
authors: G
authors: Moll
authors: S
authors: S
authors: Baiguera
authors: P
authors: P
authors: Macchiarini
mesh_terms: D000818:Animals; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods / Q000639:trends; D006801:Humans; D011108:Polymers / Q000008:administration & dosage; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000639:trends; D014132:Trachea / Q000502:physiology
chemical_list: D011108:Polymers