title: First cascade Mitsunobu reactions for the synthesis of 2-benzoxazole-N-phenyl and 2-benzimidazole-N-phenyl derivatives.
abstract: An efficient method has been developed via cascade Mitsunobu reactions to synthesize 2-benzoxazole-N-phenyl and 2-benzimidazole-N-phenyl derivatives, which are common structural motifs in medicinal chemistry. This method also provides a new application of the Mitsunobu reaction.
authors: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2 Nanwei Rd., Xicheng, Beijing, 100050, People's Republic of China.
authors: Yu
authors: Y
authors: Yan
authors: Qifei
authors: Q
authors: Zhong
authors: Nan
authors: N
authors: Zhao
authors: Gang
authors: G
authors: Liu
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D000069604:Dabigatran; D007202:Indicators and Reagents; D007536:Isomerism; D008956:Models, Chemical; D011725:Pyridines / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D001583:Benzoxazoles; D007202:Indicators and Reagents; D011725:Pyridines; C031000:benzimidazole; D000069604:Dabigatran