title: Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds.
abstract: An efficient synthetic method for the densely substituted 3-arylaminoacrylates was successfully developed via the one-pot reaction of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds such as pivaloylacetonitrile, 1,3-cyclopentanedione, and 4-hydroxycoumarin. The key step of the reaction was believed to involve the formation of a β-enamino ester and a sequential Michael addition to the in situ formed arylidene dicarbonyl compound.
authors: College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou, 225002, China.
authors: Yan
authors: Y
authors: Sun
authors: Jing
authors: J
authors: Sun
authors: Chao-Guo
authors: CG
authors: Yan
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry; D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D003517:Cyclopentanes / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015110:4-Hydroxycoumarins; D000179:Acrylates; D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D003517:Cyclopentanes; D006841:Hydrocarbons, Aromatic; D011422:Propionates; C068805:4-hydroxycoumarin