title: Spontaneous staphylococcal cassette chromosome mec element excision in Staphylococcus aureus nasal carriers.
abstract: Among 23 patients carrying methicillin-resistant Staphylococcus aureus (MRSA) in their anterior nares, 6 (26%) also carried methicillin-susceptible S. aureus (MSSA) as less prevalent flora. In 4 of the 6 patients, the MSSA was unrelated to prevalent MRSA, as determined by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and staphylococcal protein A (spa) typing. However, in two patients, the strains were identical except for the absence of spontaneous staphylococcal cassette chromosome mec (SCCmec). We consider this evidence of spontaneous SCCmec excision in vivo.
authors: Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
authors: Sam
authors: S
authors: Boundy
authors: Qixun
authors: Q
authors: Zhao
authors: Carly
authors: C
authors: Fairbanks
authors: Lauren
authors: L
authors: Folgosa
authors: Michael
authors: M
authors: Climo
authors: Gordon L
authors: GL
authors: Archer
mesh_terms: D002353:Carrier State / Q000382:microbiology*; D002876:Chromosomes, Bacterial; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D009297:Nasal Mucosa / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D004269:DNA, Bacterial