title: Hla-a and hla-B alleles associated in psoriasis patients from mumbai, Western India.
abstract: BACKGROUND
  Psoriasis, a common autoimmune disorder characterized by T cell-mediated keratinocyte hyperproliferation, is known to be associated with the presence of certain specific Human Leukocyte Antigen (HLA) alleles.
  
  
  OBJECTIVE
  To evaluate distribution of HLA-A and HLA-B alleles and hence identify the susceptible allele of psoriasis from patients in Western India.
  
  
  METHODS
  The study design included 84 psoriasis patients and 291 normal individuals as controls from same geographical region. HLA-A and HLA-B typing was done using Serology typing. Standard statistical analysis was followed to identify the odds ratio (OR), allele frequencies, and significant P value using Graphpad software.
  
  
  RESULTS
  The study revealed significant increase in frequencies of HLA-A2 (OR-3.976, P<0.0001), B8 (OR-5.647, P<0.0001), B17 (OR-5.452, P<0.0001), and B44 (OR-50.460, P<0.0001), when compared with controls. Furthermore, the frequencies of HLA-A28 (OR-0.074, P=0.0024), B5 (OR-0.059, P<0.0001), B12 (OR-0.051, P=0.0002), and B15 (OR-0.237, P=0.0230) were significantly decreased in psoriasis patients.
  
  
  CONCLUSIONS
  This study shows the strong association of HLA-A2, B8, and B17 antigens with psoriasis conferring susceptibility to psoriasis patients from Western India, while the antigens HLA-A28, B5, and B12 show strong negative association with the disease.
authors: National Institute of Immunohaematology, Indian Council of Medical Research, 13 Floor, K.E.M. Hospital, Parel, Mumbai, India.
authors: Shankarkumar
authors: S
authors: Umapathy
authors: Aruna
authors: A
authors: Pawar
authors: R
authors: R
authors: Mitra
authors: D
authors: D
authors: Khuperkar
authors: J P
authors: JP
authors: Devaraj
authors: K
authors: K
authors: Ghosh
authors: U
authors: U
authors: Khopkar