title: [Bone and calcium update; bone research update. Osteoclastogenesis and osteoimmunology].
abstract: Bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption. This restructuring process called "bone remodeling" is important not only for maintaining bone mass and strength, but also for mineral homeostasis. Excessive osteoclast activity leads to pathological bone resorption, as seen in a variety of local or generalized osteopenic conditions such as rheumatoid arthritis, cancer bone metastasis and osteoporosis. The immune and skeletal systems share various molecules including cytokines, signaling molecules, transcription factors and membrane receptors. The scope of osteoimmunology has been extended to encompass a wide range of molecular and cellular interactions, the elucidation of which will provide a scientific basis for future therapeutic approaches to diseases related to the immune and skeletal systems.
authors: Department of Cell Signaling, Tokyo Medical & Dental University, Japan.
authors: Tomoki
authors: T
authors: Nakashima
authors: Mikihito
authors: M
authors: Hayashi
authors: Hiroshi
authors: H
authors: Takayanagi
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000628:therapy; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics; D016207:Cytokines / Q000502:physiology; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D050778:NFATC Transcription Factors / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology* / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D016207:Cytokines; D050778:NFATC Transcription Factors; C450519:Oscar protein, mouse; D053245:RANK Ligand; D011956:Receptors, Cell Surface; D016186:Receptor, Macrophage Colony-Stimulating Factor