title: Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment.
abstract: BACKGROUND
  We attempted to determine the preferences of women regarding the benefits they considered necessary to make adjuvant therapy worthwhile, and to compare preferences for adjuvant endocrine therapy, chemotherapy, and trastuzumab therapy. We also investigated the effect of information about cost on women's treatment preferences.
  
  
  METHODS
  Consecutive women who had a medical examination at the Breast Clinic, Ota General Hospital, were included in our study. We collected a questionnaire from a total of 365 women; 297 completed responses were included in the study.
  
  
  RESULTS
  Among 297 women, 105 had breast cancer that had been treated and 192 did not have breast cancer; 38% of women judged that a 5% or less gain in the probability of survival was sufficient to make endocrine therapy worthwhile; 28% of participants judged that chemotherapy was worthwhile; 24% of participants judged that trastuzumab therapy was worthwhile. Women indicated that they were more likely to receive adjuvant endocrine therapy than chemotherapy or trastuzumab therapy, for the same gains in the probability of survival. Cost information about treatments did not affect women's treatment preferences. Younger women tended to judge improvements in survival sufficient to make adjuvant endocrine and chemotherapy worthwhile, as compared to older women. The comparisons were statistically significant in the 10 and 20% categories for endocrine therapy and chemotherapy.
  
  
  CONCLUSIONS
  Women prefer endocrine therapy to chemotherapy or trastuzumab therapy, given the same projected treatment benefits. Younger women prefer both chemotherapy and endocrine therapy as compared with older woman.
authors: Department of Breast and Endocrine Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. niikura@is.icc.u-tokai.ac.jp
authors: Naoki
authors: N
authors: Niikura
authors: Morihiko
authors: M
authors: Kimura
authors: Takayuki
authors: T
authors: Iwamoto
authors: Naoki
authors: N
authors: Hayashi
authors: Junichi
authors: J
authors: Shintoku
authors: Yuki
authors: Y
authors: Saito
authors: Yasuhiro
authors: Y
authors: Suzuki
authors: Yutaka
authors: Y
authors: Tokuda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000523:psychology*; D017024:Chemotherapy, Adjuvant / Q000191:economics; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D007564:Japan; D008875:Middle Aged; D057240:Patient Preference; D011795:Surveys and Questionnaires; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab