title: Clinical and virologic outcomes in patients with oseltamivir-resistant seasonal influenza A (H1N1) infections: results from a clinical trial.
abstract: Nineteen patients with oseltamivir-resistant seasonal influenza A (H1N1) infections were randomized to receive oseltamivir or placebo. Nasopharyngeal swabs were obtained, and clinical and virologic outcomes were compared, stratified by early or late treatment. Neuraminidase inhibition assay and pyrosequencing for H275Y confirmed resistance. Twelve (63%) patients received oseltamivir; 8 (67%) received late treatment. Seven (37%) patients received placebo; 6 (86%) presented >48 hours after onset. Time to 50% decrease in symptom severity, complete symptom resolution, and first negative culture were shortest among the early treatment group. While sample size prohibits a strong conclusion, future studies should evaluate for similar trends.
authors: Epidemic Intelligence Service, Office of Workforce and Career Development assigned to Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors: Nila J
authors: NJ
authors: Dharan
authors: Alicia M
authors: AM
authors: Fry
authors: Burney A
authors: BA
authors: Kieke
authors: Laura
authors: L
authors: Coleman
authors: Jennifer
authors: J
authors: Meece
authors: Mary
authors: M
authors: Vandermause
authors: Larisa V
authors: LV
authors: Gubareva
authors: Alexander I
authors: AI
authors: Klimov
authors: Edward A
authors: EA
authors: Belongia
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use*; D012621:Seasons; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir