title: [Endosymbionts of arthropods and nematodes: allies to fight infectious diseases?].
abstract: Arthropods and nematodes are important protagonists in human health because either they act as vectors of pathogens (bacteria, protozoa, viruses or fungus), or are themselves parasites. Fighting infectious diseases is based essentially on vaccination (prevention) or chemotherapeutic (curative) approaches in human, but one can envisage as an alternative to reduce the number of vectors or limit their ability to spread pathogens. Such strategies controlling dissemination will undoubtedly benefit from the knowledge accumulated by recent works on powerful mechanisms developed by symbiotic insect bacteria such as Wolbachia to popagate in arthropods and nematods. This review summarizes these recent data, and indicate how these mechanisms can be manipulated to reduce the dissemination of insect vectors propagating human diseases.
authors: Université Lyon 1, Laboratoire de biométrie et biologie évolutive, Villeurbanne, France. fabrice.vavre@univ-lyon1.fr
authors: Fabrice
authors: F
authors: Vavre
authors: Patrick
authors: P
authors: Mavingui
mesh_terms: D000818:Animals; D001181:Arthropods / Q000235:genetics / Q000382:microbiology*; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D003141:Communicable Diseases / Q000628:therapy*; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D009348:Nematoda / Q000235:genetics / Q000382:microbiology*; D013559:Symbiosis / Q000235:genetics / Q000502:physiology*