title: Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss.
abstract: We describe successful ovulation induction with low-dose hCG administration in addition to hMG in a patient with refractory hypothalamic amenorrhea. A 24-year-old woman with weight loss-related amenorrhea underwent ovulation induction and intracytoplasmic sperm injection (ICSI). Administration of exogenous gonadotropins was ineffective in ovulation induction. Supplementation with low-dose hCG in order to increase luteinizing hormone (LH) activity in the late follicular phase produced late folliculogenesis and steroidogenesis, and ovulation was then successfully induced. This report reacknowledges the critical role that LH plays cooperatively with follicle-stimulating hormone in both folliculogenesis and steroidogenesis.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
authors: Ryo
authors: R
authors: Tsutsumi
authors: Akihisa
authors: A
authors: Fujimoto
authors: Yutaka
authors: Y
authors: Osuga
authors: Miyuki
authors: M
authors: Harada
authors: Yuri
authors: Y
authors: Takemura
authors: Minako
authors: M
authors: Koizumi
authors: Tetsu
authors: T
authors: Yano
authors: Yuji
authors: Y
authors: Taketani
mesh_terms: D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy* / Q000209:etiology; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D008596:Menotropins / Q000008:administration & dosage*; D011247:Pregnancy; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D004338:Drug Combinations; D008596:Menotropins