title: Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats.
abstract: Tacrolimus is a well-known potent immunosuppressant agent, which has various drug-drug or food-drug interactions. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. So, we investigated the effect of pomelo after its administration for one day or 3 consecutive days on the pharmacokinetics of tacrolimus in rats. We also confirmed the effects of grapefruit, turmeric, and ginger. The tacrolimus blood concentrations of the rats pre-treated with 100% pomelo juice were significantly higher than those pre-treated with water. On the other hand, the tacrolimus blood concentrations of the rats pre-treated with 50% pomelo juice were not significantly different from those pre-treated with water. The pomelo-tacrolimus interaction showed concentration dependency. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration. The inhibitory effect of 100% pomelo juice disappeared 3 days after intake. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. We could confirm the pomelo-tacrolimus interaction, which we discovered in a case study, quantitatively. We newly found the influence of turmeric and ginger on tacrolimus pharmacokinetics, comparable to pomelo.
authors: Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki.
authors: Kanoko
authors: K
authors: Egashira
authors: Hitoshi
authors: H
authors: Sasaki
authors: Shun
authors: S
authors: Higuchi
authors: Ichiro
authors: I
authors: Ieiri
mesh_terms: D000818:Animals; D001628:Beverages; D002957:Citrus; D032083:Citrus paradisi / Q000378:metabolism; D030024:Curcuma / Q000378:metabolism*; D018565:Food-Drug Interactions / Q000502:physiology*; D020939:Zingiber officinale / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016559:Tacrolimus / Q000378:metabolism*
chemical_list: D010936:Plant Extracts; C012596:turmeric extract; D016559:Tacrolimus