title: Gender differences in the prevalence of metabolic syndrome in 50-year-old Swedish men and women with hypertension born in 1953.
abstract: To investigate potential gender differences in the role of hypertension as a risk factor for metabolic syndrome (MetS) we used a random population sample of 50-year-old men (n=595) and women (n=667; all born in 1953) who were examined in 2003-2004. Systolic (SBP) and diastolic (DBP) blood pressure values were dichotomized at ≥ 140 mm Hg and ≥ 90 mm Hg, respectively. MetS was defined using NCEP (National Cholesterol Education Programme) and IDF (International Diabetes Federation) criteria. MetS was more prevalent in men than in women (NCEP 16% versus 10%, P=0.003; IDF 26% versus 16%, P=0.000) and systolic hypertension was more common in men than in women (high SBP 24% versus 18%, P=0.003; high DBP 29% versus 24%, P=0.074). Women with high SBP had about a seven-fold increased NCEP risk compared with normotensive women (odds ratio (OR) 6.91, confidence interval (CI) 2.90-16.42), whereas high SBP in men was associated with about a three-fold increased NCEP risk (OR 2.72, CI 1.69-4.38). A similar pattern was observed for the IDF criterion of MetS. All interaction terms (sex × hypertension) were significant at P<0.01. At middle age, despite that fewer women had hypertension or MetS than men, hypertension carries a relatively greater risk for MetS in women than in men.
authors: Department of Emergency and Cardiovascular Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. masuma.novak@gu.se
authors: M
authors: M
authors: Novak
authors: L
authors: L
authors: Björck
authors: L
authors: L
authors: Welin
authors: C
authors: C
authors: Welin
authors: K
authors: K
authors: Manhem
authors: A
authors: A
authors: Rosengren
mesh_terms: D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012727:Sex Characteristics; D013548:Sweden; D013599:Systole