title: Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation.
abstract: Allergen-specific immunotherapy is an effective clinical treatment for hypersensitivity to many allergens. Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of basophil activation as a biomarker of clinical outcomes. This review examines the evidence for different pathways of basophil modulation associated with various forms of immunotherapy. Better understanding the molecular mechanisms of basophil activation and desensitization and the relationship between suppression of these effector cells to clinical outcomes holds promise for further development and improvement in potential therapies for allergic diseases.
authors: Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Boston, MA, USA. spatil35@partners.org
authors: S U
authors: SU
authors: Patil
authors: W G
authors: WG
authors: Shreffler
mesh_terms: D000485:Allergens / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D003888:Desensitization, Immunologic; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D006636:Histamine Release / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000628:therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007165:Immunosuppression Therapy; D016032:Randomized Controlled Trials as Topic; D017455:Receptors, IgE / Q000276:immunology; D017452:Receptors, IgG / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D007074:Immunoglobulin G; D017455:Receptors, IgE; D017452:Receptors, IgG; D007073:Immunoglobulin E