title: In vitro study of magnetite-amyloid β complex formation.
abstract: Biogenic magnetite (Fe(3)O(4)) has been identified in human brain tissue. However, abnormal concentration of magnetite nanoparticles in the brain has been observed in different neurodegenerative pathologies. In the case of Alzheimer's disease (AD), these magnetic nanoparticles have been identified attached to the characteristic brain plaques, which are mainly formed by fibrils of amyloid β peptide (Aβ). However, few clues about the formation of the magnetite-Aβ complex have been reported. We have investigated the interaction between these important players in AD with superconducting quantum interference, scanning electron microscope, surface plasmon resonance, and magnetic force microscopy. The results support the notion that the magnetite-Aβ complex is created before the synthesis of the magnetic nanoparticles, bringing a highly stable interaction of this couple. .
authors: Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain. mmir@ibec.pcb.ub.es
authors: Mònica
authors: M
authors: Mir
authors: Islam Bogachan
authors: IB
authors: Tahirbegi
authors: Juan José
authors: JJ
authors: Valle-Delgado
authors: Xavier
authors: X
authors: Fernàndez-Busquets
authors: Josep
authors: J
authors: Samitier
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000648:ultrastructure*; D001665:Binding Sites; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D008422:Materials Testing; D010316:Particle Size; D011485:Protein Binding; D013499:Surface Properties
chemical_list: D016229:Amyloid beta-Peptides; D058185:Magnetite Nanoparticles