title: Targeting DNA repair and the cell cycle in glioblastoma.
abstract: Glioblastoma is a disease with poor outcomes despite standard therapy. Specific targeting of the DNA damage response is a strategy that is becoming increasingly employed in oncology and has intriguing potential for improving outcomes in glioblastoma. DNA damage targeting has implications for improving current therapy as well as the potential to leverage inherent differences in glioblastoma cells to widen the therapeutic window.
authors: Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, 75 Francis Street, ASB1-L2, Boston, MA 02115, USA. bmalexander@partners.org
authors: Brian M
authors: BM
authors: Alexander
authors: Nancy
authors: N
authors: Pinnell
authors: Patrick Y
authors: PY
authors: Wen
authors: Alan
authors: A
authors: D'Andrea
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*