title: Association of six-minute walk distance (6MWD) with resting pulmonary function in patients with chronic obstructive pulmonary disease (COPD).
abstract: BACKGROUND
  The six-minute walk test (6MWT) is widely used for integrated assessment of patients with chronic obstructive pulmonary disease (COPD). However, little is known concerning which resting pulmonary function test measurements relate to six-minute walk distance (6MWD).
  
  
  METHODS
  We retrospectively analyzed consecutive data of spirometry, lung volume analysis, and measurements of diffusing capacity of the lung for carbon monoxide (DLCO) and 6MWT from total of one-hundred and thirty patients with COPD. Univariate and multivariate analyses were performed to examine the relationships between 6MWD and variables.
  
  
  RESULTS
  By linear regression analysis, 6MWD was significantly associated with age, weight, BMI, FEV1.0, FEV1.0 (% predicted), IC, TLC, IC/TLC, FEF25-75, DLCO (% predicted), and DLCO/VA. Stepwise multiple regression analysis revealed that age (r2 = 0.173; p < 0.0001), IC (r2 = 0.18; p < 0.0001), and DLCONA (r2 = 0.238; p < 0.0001) significantly accounted for 6MWD.
  
  
  CONCLUSIONS
  The present results suggest that age, IC, and DLCONA were significantly associated with 6MWD in patients with COPD.
authors: Department of Respiratory Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan. pattypoti@hotmail.com
authors: Hiroki
authors: H
authors: Fujimoto
authors: Kazuhisa
authors: K
authors: Asai
authors: Tetsuya
authors: T
authors: Watanabe
authors: Hiroshi
authors: H
authors: Kanazawa
authors: Kazuto
authors: K
authors: Hirata
mesh_terms: D000367:Age Factors; D000368:Aged; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007564:Japan; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D011237:Predictive Value of Tests; D011653:Pulmonary Diffusing Capacity; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013147:Spirometry; D013997:Time Factors; D014109:Total Lung Capacity; D016138:Walking