title: Salivary alpha amylase and cortisol levels in children with global developmental delay and their relation with the expectation of dental care and behavior during the intervention.
abstract: The purpose of this study was to analyze the alpha-amylase (sAA) and cortisol levels in children with Global developmental delay (GDD) before and after dental treatment and its association with the children's behavior during treatment. The morning salivary cortisol levels and activity of sAA of 33 children with GDD were evaluated before and after dental treatment and were compared to 19 healthy children. The behavior of children with GDD during dental care was assessed by the Frankl scale. Children with GDD showed lower levels of sAA activity than healthy children, but this result was not significant. The salivary cortisol levels were similar between GDD and healthy children. GDD children showed increased levels of sAA (but not cortisol) prior to the dental treatment as compared to the post-treatment phase. GDD children who showed less favorable behavior during dental care had higher levels of sAA and salivary cortisol than GDD children with more favorable behavior, but only the sAA results were significant. In conclusion, GDD children show hyperactivity of the SNS-axis in anticipation of dental treatment which indicates the need for strategies to reduce their anxiety levels before and during dental care.
authors: Center for Dental Care of Persons with Disabilities - CAOE, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. marciokada@hotmail.com
authors: Márcio José Possari
authors: MJ
authors: dos Santos
authors: Daniel Galera
authors: DG
authors: Bernabé
authors: Ana Cláudia de Melo Stevanato
authors: AC
authors: Nakamune
authors: Silvia Helena Venturoli
authors: SH
authors: Perri
authors: Sandra Maria Herondina Coelho Ávila
authors: SM
authors: de Aguiar
authors: Sandra Helena Penha
authors: SH
authors: de Oliveira
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002652:Child Behavior; D016854:Dental Anxiety / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology; D019140:Dental Care for Children / Q000523:psychology*; D002658:Developmental Disabilities / Q000378:metabolism / Q000523:psychology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D012463:Saliva / Q000378:metabolism; D055291:Salivary alpha-Amylases / Q000378:metabolism*; D013315:Stress, Psychological / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology
chemical_list: D015415:Biomarkers; D055291:Salivary alpha-Amylases; D006854:Hydrocortisone