title: In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum).
abstract: During our search to discover new antitrypanosomal compounds, eight known plant compounds (three phenolic compounds and five kawa lactones) were evaluated for in vitro activity against Trypanosoma brucei brucei. Among them, we found two phenolic compounds and three kawa lactones possessing an α-pyrone influenced antitrypanosomal property. In particular, β-phenethyl caffeate, farnesyl caffeate and dihydrokawain exhibited high or moderate selective and potent antitrypanosomal activity in vitro. We detail here the antitrypanosomal activity and cytotoxicities of the compounds, in comparison with two commonly used antitrypanosomal drugs (eflornithine and suramin). Our findings represent the first report of the promising trypanocidal activity of these compounds.
authors: Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. otoguro@lisci.kitasato-u.ac.jp
authors: Kazuhiko
authors: K
authors: Otoguro
authors: Masato
authors: M
authors: Iwatsuki
authors: Aki
authors: A
authors: Ishiyama
authors: Miyuki
authors: M
authors: Namatame
authors: Aki
authors: A
authors: Nishihara-Tsukashima
authors: Hiroaki
authors: H
authors: Kiyohara
authors: Toshihiro
authors: T
authors: Hashimoto
authors: Yoshinori
authors: Y
authors: Asakawa
authors: Satoshi
authors: S
authors: Omura
authors: Haruki
authors: H
authors: Yamada
mesh_terms: D020901:Kava / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D011429:Propolis / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: D007783:Lactones; D011753:Pyrones; D014344:Trypanocidal Agents; C510430:dihydrokawain; D011429:Propolis