title: Salbutamol modulation of ion transport in sheep parietal pleura is protein dependent.
abstract: The formation of pleural effusion during pulmonary edema is an important physiological mechanism of resolution of alveolar flooding. In cases of pulmonary edema resulting from acute respiratory distress syndrome (ARDS) these effusions are exudative, having high protein load. To this end, the effect of salbutamol in the presence of protein, on the ion transport properties of the sheep parietal pleura was investigated by Ussing chamber experiments. Our results show that salbutamol increases ion transport in the presence of protein in sheep parietal pleura by stimulation of β(2)-adrenergic receptors since this effect was completely abolished by the specific β(2)-adrenergic blocker, ICI-118551. This finding may be of importance regarding the acceleration of the resolution of protein-rich pleural effusions occurring in cases of ARDS.
authors: Department of Physiology, University of Thessaly Medical School, 41110, Larissa, Greece. szarog@med.uth.gr
authors: Sotirios Georgios
authors: SG
authors: Zarogiannis
authors: Aristotelis Stamatios
authors: AS
authors: Filippidis
authors: Chrissi
authors: C
authors: Hatzoglou
authors: Paschalis Adam
authors: PA
authors: Molyvdas
authors: Konstantinos
authors: K
authors: Gourgoulianis
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D010994:Pleura / Q000187:drug effects* / Q000502:physiology; D011412:Propanolamines / Q000494:pharmacology; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D012756:Sheep
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D018343:Receptors, Adrenergic, beta-2; D012710:Serum Albumin, Bovine; C026777:ICI 118551; D000420:Albuterol