title: The insulin-like growth factor system in kidney disease and hypertension.
abstract: OBJECTIVE
  The insulin-like growth factor system plays an important role in renal physiology and it is perturbed in a range of kidney diseases.
  
  
  RESULTS
  Some insulin-like growth factor (IGF) actions in the kidney are mediated by nitric oxide. Growth hormone and IGF-binding proteins may contribute to renal diseases via effects on podocytes and proximal tubule cells. In contrast, growth hormone and IGF-I may counteract the catabolic consequences of end-stage renal disease. Polymorphisms in the IGF system are associated with hypertension.
  
  
  CONCLUSIONS
  Further studies are needed to determine whether modulating the IGF system may have a role in treating kidney diseases and/or hypertension.
authors: Department of Endocrinology and Diabetes, The Alfred, Melbourne, Australia. leon.bach@monash.edu
authors: Leon A
authors: LA
authors: Bach
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D010641:Phenotype; D011110:Polymorphism, Genetic; D017451:Receptors, Somatomedin / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000959:Antihypertensive Agents; D017451:Receptors, Somatomedin; D013002:Somatomedins