title: [Association of type 1 diabetes mellitus and epilepsy in children. A cohort of 10 cases].
abstract: The association of type 1 diabetes mellitus (DM) and epilepsy has been previously reported. However, the physiopathology of this association remains misunderstood.
  
  
  OBJECTIVE
  To describe epilepsy combined with type 1 DM in children.
  
  
  METHODS
  Retrospective monocentric study of all the epileptic and type 1 diabetic children consulting at the Timone University Hospital, Marseille, France. For each patient, the type of epilepsy and its electroclinical and radiographic characteristics were studied as well as the type of diabetes (biological characteristics, glycemic control), and the onset of these 2 diseases.
  
  
  RESULTS
  Ten patients are reported. Five suffered from generalized epilepsy (4 idiopathic, 1 nonidiopathic) and 5 from focal epilepsy (4 non-idiopathic, 1 idiopathic). For most of these cases, presence of GAD (glutamic acid decarboxylase) autoantibodies were confirmed and epilepsy followed diabetes.
  
  
  CONCLUSIONS
  The 2 most common types of epilepsy in this association are idiopathic generalized epilepsy and non-idiopathic temporal epilepsy. Several mechanisms could be involved (immune, glycemia, and genetic disorders).
authors: Service de neurologie pédiatrique, Assistance publique-Hôpitaux de Marseille, CHU La Timone, 264, rue Saint-Pierre, 13005 Marseille, France. emilie.caietta@ap-hm.fr
authors: E
authors: E
authors: Caietta
authors: C
authors: C
authors: Halbert
authors: A
authors: A
authors: Lépine
authors: A
authors: A
authors: Khammar
authors: A
authors: A
authors: Cano
authors: M
authors: M
authors: Gavaret
authors: J
authors: J
authors: Mancini
authors: N
authors: N
authors: Villeneuve
authors: B
authors: B
authors: Chabrol
authors: G
authors: G
authors: Simonin
authors: R
authors: R
authors: Reynaud
authors: M
authors: M
authors: Milh
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004829:Epilepsy, Generalized / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005968:Glutamate Decarboxylase / Q000097:blood*; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D005968:Glutamate Decarboxylase