title: Quality of life and the effect of memantine in dementia with lewy bodies and Parkinson's disease dementia.
abstract: OBJECTIVE
  To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias.
  
  
  METHODS
  A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health.
  
  
  RESULTS
  Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure.
  
  
  CONCLUSIONS
  This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.
authors: Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden. v.larsson@ucl.ac.uk
authors: Victoria
authors: V
authors: Larsson
authors: Knut
authors: K
authors: Engedal
authors: Dag
authors: D
authors: Aarsland
authors: Carina
authors: C
authors: Wattmo
authors: Lennart
authors: L
authors: Minthon
authors: Elisabet
authors: E
authors: Londos
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003704:Dementia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000188:drug therapy* / Q000523:psychology*; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D007980:Levodopa; D008559:Memantine