title: The level of native and oxidized lipoprotein(a) in children with nephrotic syndrome.
abstract: OBJECTIVE
  To investigate lipoprotein(a) [Lp(a)], oxidized Lp(a) [ox-Lp(a)] and Lp(a) immune complex [Lp(a)-IC] levels in children with nephrotic syndrome (NS).
  
  
  METHODS
  Plasma Lp(a), ox-Lp(a) and Lp(a)-IC levels were determined in 106 NS children in acute-period, 42 in remission and 155 controls.
  
  
  RESULTS
  Lp(a) and ox-Lp(a) levels were significantly higher in acute-period and remission NS than in control. Ox-Lp(a) levels in acute-period NS were higher than in remission. Lp(a)-IC levels in acute-period NS were higher than in control. Lp(a), ox-Lp(a) and Lp(a)-IC were found negatively related with albumin in NS. Lp(a), ox-Lp(a) and Lp(a)-IC levels decreased after use of steroid therapy. Multiple linear regression analysis found relative change of albumin, creatinine, urea, triglyceride and high density lipoprotein cholesterol accounted for 78.9% of variation in ox-Lp(a).
  
  
  CONCLUSIONS
  Lp(a), ox-Lp(a) and Lp(a)-IC levels were increased in NS children, which may play an important role in the processes of atherosclerosis.
authors: Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China.
authors: Han-qing
authors: HQ
authors: Li
authors: Jia
authors: J
authors: Wu
authors: Dong-Mei
authors: DM
authors: Niu
authors: Yong-Hui
authors: YH
authors: Shi
authors: Chun-ni
authors: CN
authors: Zhang
authors: Jun-jun
authors: JJ
authors: Wang
mesh_terms: D000418:Albumins / Q000378:metabolism; D050197:Atherosclerosis; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007107:Immune System; D007223:Infant; D007668:Kidney / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry*; D012044:Regression Analysis; D012074:Remission Induction
chemical_list: D000418:Albumins; D008055:Lipids; D017270:Lipoprotein(a); D010100:Oxygen