title: Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering.
abstract: The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.
authors: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India.
authors: Anjali
authors: A
authors: Tripathi
authors: Sekaran
authors: S
authors: Saravanan
authors: Soumitri
authors: S
authors: Pattnaik
authors: Ambigapathi
authors: A
authors: Moorthi
authors: Nicola C
authors: NC
authors: Partridge
authors: Nagarajan
authors: N
authors: Selvamurugan
mesh_terms: D000327:Adsorption; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism; D048271:Chitosan / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D004926:Escherichia coli / Q000378:metabolism; D008855:Microscopy, Electron, Scanning / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013211:Staphylococcus aureus / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods; D015032:Zinc / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003300:Copper; D048271:Chitosan; D017886:Durapatite; D015032:Zinc