title: Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: a single institutional experience.
abstract: Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.
authors: Institute of Microbiology, Madras Medical College and Rajiv Gandhi Govt. General Hospital, Chennai 600 003, India. deeparsn@yahoo.co.in
authors: R
authors: R
authors: Deepa
authors: P
authors: P
authors: Balapriya
authors: K G
authors: KG
authors: Venkatesh
authors: T
authors: T
authors: Sabeetha
authors: J
authors: J
authors: Sasikala
authors: G
authors: G
authors: Jayalakshmi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods*; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003165:Complement System Proteins