title: A continuous and adsorptive bioprocess for efficient production of the natural aroma chemical 2-phenylethanol with yeast.
abstract: Natural 2-phenylethanol is a high value aroma chemical and can be produced from l-phenylalanine via Ehrlich pathway by yeasts. Due to serious product inhibition, the space-time yield is usually low. A continuous approach using macroporous resin as in situ adsorbent made it possible that the quantity and viability of the cells were improved simultaneously. With Saccharomyces cerevisiae sp. strain R-UV3, the highest space-time yield of 0.90 gL(-1)h(-1) reported so far was obtained.
authors: College of Biological Science and Technology, Fuzhou University, No. 2 Xuan Yuan Road, Fuzhou, Fujian 350108, China.
authors: Hang
authors: H
authors: Wang
authors: Qingfeng
authors: Q
authors: Dong
authors: Chun
authors: C
authors: Meng
authors: Xian Ai
authors: XA
authors: Shi
authors: Yanghao
authors: Y
authors: Guo
mesh_terms: D000327:Adsorption; D019149:Bioreactors / Q000382:microbiology*; D001709:Biotechnology / Q000379:methods*; D002480:Cellulase / Q000378:metabolism*; D002482:Cellulose / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D010636:Phenols / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D010649:Phenylalanine / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000254:growth & development / Q000378:metabolism*
chemical_list: D010636:Phenols; D010649:Phenylalanine; D002482:Cellulose; D002480:Cellulase; D010626:Phenylethyl Alcohol