title: Study on antibacterial dental resin using tri-n-butyl(4-vinylbenzyl)phosphonium chloride.
abstract: The antibacterial properties of a polymeric phosphonium salt were studied to determine its suitability as an additive to develop an antibacterial dental resin. The phosphonium salt monomer studied was tri-n-butyl(4-vinylbenzyl)phosphonium chloride (VP), and acrylic acid (AC) and methacryloyloxyethyl trimethyl ammonium chloride (MA) were used as controls. The antibacterial activity of these monomers and their corresponding polymers (PVP, PAC, and PMA) against Streptococcus mutans (S. mutans) was examined. When incubating S. mutans in a medium containing 10 μmol/mL for 24 hours, the antibacterial activity of PVP against S. mutans was high, while the antibacterial activity of PMA and VP was lower. AC, PAC and PMA exhibited the lowest antibacterial activity. The mechanical properties of the copolymers of methyl methacrylate, 2-hydroxyethyl methacrylate, and VP decreased as VP content increased, and were lower than those of poly(methyl methacrylate).
authors: Department of Biomaterials and Devices, Kanagawa Dental College.
authors: Shigeaki
authors: S
authors: Kurata
authors: Nobushiro
authors: N
authors: Hamada
authors: Akihiko
authors: A
authors: Kanazawa
authors: Takeshi
authors: T
authors: Endo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008826:Microbial Sensitivity Tests; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D012117:Resins, Synthetic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D009943:Organophosphorus Compounds; D011108:Polymers; D012117:Resins, Synthetic; C113117:tributylmethyl phosphonium chloride