title: "In situ" mantle cell lymphoma associated with hyaline-vascular Castleman disease.
abstract: Mantle cell lymphoma (MCL) is a very rare non-Hodgkin B-cell lymphoma, with an aggressive clinical course and poor response to conventional therapy. Few cases of "in situ" MCL were reported in the last years. We present the case of a 31-year-old woman with a unique cervical lymphadenopathy. The morphologic findings are of hyaline-vascular Castleman disease (HV-CD). Immunohistochemical stain for cyclin D1 detects scattered cyclin D1+ cells within the mantle zones of few reactive-appearing lymphoid follicles, corresponding to the definition of "in situ" MCL. We also performed cyclin D1 in other 27 cases of CD (13 HV-CD and 14 plasma-cell CD) but the reported case was the only who associated "in situ" MCL. An adequate immunohistochemical panel, including a marker for cyclin D1, is required to differentiate this neoplasm from follicular hyperplasia. From our knowledge, this is the first reported case of "in situ" MCL associated with HV-CD.
authors: Department of Hematology-Fundeni, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cameliadobrea@yahoo.com
authors: Camelia
authors: C
authors: Dobrea
authors: Mihaela
authors: M
authors: Mihai
authors: E
authors: E
authors: Dănăilă
authors: Amelia
authors: A
authors: Găman
authors: D
authors: D
authors: Coriu
authors: Iulia
authors: I
authors: Ursuleac
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D005260:Female; D018858:Germinal Center / Q000473:pathology; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D020522:Lymphoma, Mantle-Cell / Q000150:complications* / Q000473:pathology; D009367:Neoplasm Staging