title: IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1-13C]pyruvate.
abstract: Metabolic imaging with hyperpolarized [1-(13)C]pyruvate offers the unique opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust acquisition and reconstruction techniques are required for capturing the wealth of information present for the limited duration of the hyperpolarized state (~1 min). In this study, the Dixon/IDEAL type of water-fat separation is expanded toward spectroscopic imaging of [1-(13) C]pyruvate and its down-stream metabolites. For this purpose, the spectral-spatial encoding is based on single-shot spiral image encoding and echo-time shifting in between excitations for the chemical-shift encoding. In addition, also a free-induction decay spectrum is acquired and the obtained chemical-shift prior knowledge is efficiently used in the reconstruction. The spectral-spatial reconstruction problem is found to efficiently separate into a chemical-shift inversion followed by a spatial reconstruction. The method is successfully demonstrated for dynamic, multislice [1-(13)C]pyruvate metabolic MR imaging in phantom and in vivo rat experiments.
authors: GE Global Research, Munich, Germany. florian.wiesinger@gmail.com.
authors: Florian
authors: F
authors: Wiesinger
authors: Eliane
authors: E
authors: Weidl
authors: Marion I
authors: MI
authors: Menzel
authors: Martin A
authors: MA
authors: Janich
authors: Oleksandr
authors: O
authors: Khegai
authors: Steffen J
authors: SJ
authors: Glaser
authors: Axel
authors: A
authors: Haase
authors: Markus
authors: M
authors: Schwaiger
authors: Rolf F
authors: RF
authors: Schulte
mesh_terms: D000280:Administration, Inhalation; D000465:Algorithms; D000818:Animals; D002247:Carbon Isotopes / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008657:Metabolic Clearance Rate; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D019289:Pyruvic Acid / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D002247:Carbon Isotopes; D019289:Pyruvic Acid