title: A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities.
abstract: A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.|Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Hongyu
authors: H
authors: Zhang
authors: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany.
authors: Hongpeng
authors: H
authors: Wang
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Hongli
authors: H
authors: Cui
authors: Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China.
authors: Zonggang
authors: Z
authors: Li
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Zeping
authors: Z
authors: Xie
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Yang
authors: Y
authors: Pu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Fuchao
authors: F
authors: Li
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Song
authors: S
authors: Qin
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D050296:Microbial Viability / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D014871:Water Microbiology
chemical_list: D000873:Anthracenes; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents