title: Indices of central aortic blood pressure and their impact on cardiovascular outcomes.
abstract: Elevated peripheral (brachial) blood pressure (PBP) is related to hard cardiovascular outcomes and remains the main target for antihypertensive therapy. However, central aortic blood pressure (CABP) can be measured noninvasively and could potentially prove to be a more important marker of cardiovascular diseases in future. Several studies have shown association of CABP with cardiovascular mortality, coronary artery disease, left-ventricular hypertrophy and atherosclerosis. Furthermore, the impact of various classes of antihypertensive agents on CABP is different from their impact on PBP. We review the significance of CABP in cardiovascular outcomes and the differential impact of antihypertensive therapy on CABP.
authors: Department of Internal Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA.
authors: Bhavin C
authors: BC
authors: Patel
authors: Raghav
authors: R
authors: Gupta
authors: Faisal
authors: F
authors: Latif
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D004548:Elasticity; D006801:Humans; D011237:Predictive Value of Tests; D011673:Pulsatile Flow; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents