title: Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population.
abstract: To investigate the effect of the vitamin D receptor (VDR) Fok I Bsm I Dde I Apa I Taq I polymorphism on the clinical presentation of calcium urolithiasis, 464 patients with urolithiasis and 450 age- and sex-matched healthy controls were recruited from The First Affiliated Hospital of Zhejiang University between January 2010 and March 2011. Five SNPs of VDR polymorphism were detected using polymerase chain reaction-based restriction analysis. The frequency of VDR Apa I genotypes between the patients and the healthy controls was significantly different (P = 0.006). Apa I a allele was found to be associated with increased risk of stone recurrence (P = 0.028). We also found Fok I Dde I Apa I showed a significant difference between male and female in the patients group (P < 0.05). Haplotype analysis of the five VDR polymorphisms showed a significant association with urolithiasis (global-P value = 0.0001). Genetic polymorphisms of VDR are important in the clinical presentation of patients with calcium urolithiasis in the Han population of southern China.
authors: Department of Urology, School of Medicine, The First Affiliated Hospital, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China.
authors: Shuai
authors: S
authors: Wang
authors: Xiao
authors: X
authors: Wang
authors: Jian
authors: J
authors: Wu
authors: Yiwei
authors: Y
authors: Lin
authors: Hong
authors: H
authors: Chen
authors: Xiangyi
authors: X
authors: Zheng
authors: Cheng
authors: C
authors: Zhou
authors: Liping
authors: L
authors: Xie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D052878:Urolithiasis / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; D002118:Calcium