title: MTHFR gene polymorphisms in bladder cancer in the Turkish population.
abstract: Bladder cancer is the 9th most common cancer and is responsible for malignancy related death all on the world. Folate and folate related enzyme polymorphisms related to the cancer risk. The methylene tethrahydrofolate reductase (MTHFR) enzyme is folate related and association of bladder cancer and MTHFR gene. Our purpose was to assess the prevalence of MTHFR gene 677 CT and 1298 AC polymorphisms and Bladder cancer in Turkey. We intended that bladder cancer patients and controls and we used the Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods. The MTHFR gene C677T and A1298C polymorphisms were associated with an increased risk of bladder cancer in our population (For the MTHFR gene C677T polymorphism and A1298C polymorphism; p=0.036<0.05; p=0.278>0.05 respectively). Consequently, the MTHFR gene C677T polymorphism augments the risk of bladder cancer in Turkey.
authors: Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. muzeyyenizmirli@gmail.com
authors: Muzeyyen
authors: M
authors: Izmirli
authors: Nihal
authors: N
authors: Inandiklioglu
authors: Deniz
authors: D
authors: Abat
authors: Davut
authors: D
authors: Alptekin
authors: Osman
authors: O
authors: Demirhan
authors: Zuhtu
authors: Z
authors: Tansug
authors: Yildirim
authors: Y
authors: Bayazit
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014421:Turkey; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000235:genetics*
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)