title: Long-term results of therapy with mycophenolate mofetil in ocular mucous membrane pemphigoid.
abstract: OBJECTIVE
  To assess the long-term efficacy and tolerability of mycophenolate mofetil (MMF) in the therapy of ocular mucous membrane pemphigoid (OcMMP).
  
  
  METHODS
  Ten patients (19 eyes) with OcMMP treated with MMF, who had a follow-up of at least 4 years, were retrospectively analyzed. Main outcome measures were inflammatory control, progression of cicatrization, and side effects.
  
  
  RESULTS
  Control of inflammation was achieved in 11 eyes (58%) of 6 patients (rate: 0.11/PY). Mild inflammatory activity was observed in 8 eyes (42%) of 4 patients (rate: 0.07/PY). Progression of conjunctival cicatrization was prevented in 47% (9/19) of the eyes. Mild progression of cicatrization was found in 42% (8/19) of the eyes. Conjunctival cicatrization had progressed to stage IV in 1 patient (11%). Treatment-related side effects occurred in 7 patients (rate: 0.12/PY).
  
  
  CONCLUSIONS
  MMF is an effective agent for treatment of OcMMP. However, the drug cannot always prevent disease progression.
authors: Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany. deshka.doycheva@med.uni-tuebingen.de
authors: Deshka
authors: D
authors: Doycheva
authors: Christoph
authors: C
authors: Deuter
authors: Gunnar
authors: G
authors: Blumenstock
authors: Nicole
authors: N
authors: Stuebiger
authors: Manfred
authors: M
authors: Zierhut
mesh_terms: D000368:Aged; D002921:Cicatrix / Q000188:drug therapy / Q000517:prevention & control; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid