title: One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.
abstract: The HIV-1, HIV-2 and SIV Nef protein are known to modulate the expression of several cell surface receptors and molecules to escape the immune system, to alter T cell activation, to enhance viral replication, infectivity and transmission and overall to ensure the optimal environment for infection outcome. Consistent and continuous efforts have been made over the years to characterize the modulation of expression of each of these molecules, in the hope that a better understanding of these processes essential for HIV infection and/or pathogenesis will eventually highlight new therapeutic targets. In this article we provide an extensive review of the knowledge gained so far on this important and evolving topic.
authors: Department of Clinical Biology, Immunology and Microbiology, Ghent University, Gent, Belgium.
authors: Alessia
authors: A
authors: Landi
authors: Veronica
authors: V
authors: Iannucci
authors: Anouk Van
authors: AV
authors: Nuffel
authors: Pieter
authors: P
authors: Meuwissen
authors: Bruno
authors: B
authors: Verhasselt
mesh_terms: D015536:Down-Regulation; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000276:immunology* / Q000502:physiology
chemical_list: D011956:Receptors, Cell Surface; D054311:nef Gene Products, Human Immunodeficiency Virus