title: Computational flow dynamics of the severe m1 stenosis before and after stenting.
abstract: OBJECTIVE
  Computational flow dynamic (CFD) study has not been widely applied in intracranial artery stenosis due to requirement of high resolution in identifying the small intracranial artery. We described a process in CFD study applied to symptomatic severe intracranial (M1) stenosis before and after stenting.
  
  
  METHODS
  Reconstructed 3D angiography in STL format was transferred to Magics (Materialise NV, Leuven, Belgium) for smoothing of vessel surface and trimming of branch vessels and to HyperMesh (Altair Engineering Inc., Auckland, New Zealand) for generating tetra volume mesh from triangular surface-meshed 3D angiogram. Computational analysis of blood flow in the blood vessels was performed using the commercial finite element software ADINA Ver 8.5 (ADINA R & D, Inc., Lebanon, MA). The distribution of wall shear stress (WSS), peak velocity and pressure in a patient was analyzed before and after intracranial stenting.
  
  
  RESULTS
  Computer simulation of wall shear stress, flow velocity and wall pressure before and after stenting could be demonstrated three dimensionally by video mode according to flow vs. time dimension. Such flow model was well correlated with angiographic finding related to maximum degree of stenosis. Change of WSS, peak velocity and pressure at the severe stenosis was demonstrated before and after stenting. There was no WSS after stenting in case without residual stenosis.
  
  
  CONCLUSIONS
  Our study revealed that CFD analysis before and after intracranial stenting was feasible despite of limited vessel wall dimension and could reveal change of WSS as well as flow velocity and wall pressure.
authors: Department of Radiology and Research Institute of Radiology, Asan Medical Center, Seoul, Korea.
authors: Dae Chul
authors: DC
authors: Suh
authors: Young Bae
authors: YB
authors: Ko
authors: Sung-Tae
authors: ST
authors: Park
authors: Kyunghwan
authors: K
authors: Yoon
authors: Ok Kyun
authors: OK
authors: Lim
authors: Jin Sun
authors: JS
authors: Oh
authors: Yun Gyeong
authors: YG
authors: Jeong
authors: Jong Sung
authors: JS
authors: Kim