title: Characteristics of cochlear microphonics in infants and young children with auditory neuropathy.
abstract: CONCLUSIONS
  Cochlear microphonics (CMs) play an important role in the diagnosis of auditory neuropathy (AN). It is necessary and helpful to diagnose the sites-of-lesion in infants and children with AN by analyzing the patterns of CM amplitudes and I/O functions together.
  
  
  OBJECTIVE
  To investigate the characteristics and clinical significance of CMs in the diagnosis of AN among infants and children.
  
  
  METHODS
  A total of 36 infants and children (16 males and 20 females) were divided into two groups. Group A included 15 children (30 ears) with auditory brainstem response (ABR) absent and distortion product otoacoustic emissions (DPOAEs) present and group B included 21 children (30 ears) with ABR absent and DPOAEs absent. Fifteen normal-hearing infants (30 ears) made up the control group. Click eliciting CMs were recorded at stimulus levels of 100, 90, 80, and 70 dB nHL for each ear using a button electrode placed at the top of the forehead. A tube-clamping method was used to distinguish CMs from artifacts, and an averaging algorithm was used to obtain a clear CM waveform. The time delay and amplitude of CMs were measured in both children with AN and normal-hearing infants on (C-R)/2 waveforms, and an I/O function curve for each group was plotted with the stimulating level as input and the CM amplitude as output.
  
  
  RESULTS
  The largest identifiable CMs were generally found between 0.5 and 0.8 ms after stimulation with mean delay of 0.63 ± 0.04 ms in both group A and the control group, and 0.63 ± 0.07 ms in group B. There was no significant difference between the AN group and the control group in CM time delay. There was no significant difference (p > 0.05) between group A (AN with OAEs present, 0.47 ± 0.15 μV) and the control group (0.45 ± 0.13 μV) in CM amplitude, while CM amplitudes in children with AN with DPOAEs absent (0.24 ± 0.08 μV) were significantly lower than those in either the control group or group A (p < 0.01). The amplitude of CMs reduced with stimulus intensity in all the subjects. There was obvious nonlinearity in group A and the control group, while there was a more linear tendency in amplitude increasing on the I/O function curve in group B.
authors: Department of Otolaryngology/Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.
authors: Wei
authors: W
authors: Shi
authors: Fei
authors: F
authors: Ji
authors: Lan
authors: L
authors: Lan
authors: Si-Chao
authors: SC
authors: Liang
authors: Hai-Na
authors: HN
authors: Ding
authors: Hui
authors: H
authors: Wang
authors: Na
authors: N
authors: Li
authors: Qian
authors: Q
authors: Li
authors: Xing-Qi
authors: XQ
authors: Li
authors: Qiu-Ju
authors: QJ
authors: Wang
mesh_terms: D000704:Analysis of Variance; D001300:Audiometry, Evoked Response; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006313:Hearing Loss, Central / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology