title: Transient receptor potential vanilloid type 1 and pain development.
abstract: Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up regulated in neuropathic pain conditions. Owing to its role as pain integrator, its widespread expression in pain neuraxis and its involvement in pain development TRPV1 offers an exciting opportunity for therapeutic interventions in pain management. In particular, its supraspinal expression within the antinociceptive descending pathway, which includes periaqueductal grey (PAG) and rostral ventromedial medulla (RVM), represents an endogenous switch for extinguishing pain in pathological conditions.
authors: Department of Experimental Medicine, Pharmacology Division, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. enza.palazzo@unina2.it
authors: Enza
authors: E
authors: Palazzo
authors: Livio
authors: L
authors: Luongo
authors: Vito
authors: V
authors: de Novellis
authors: Francesco
authors: F
authors: Rossi
authors: Ida
authors: I
authors: Marabese
authors: Sabatino
authors: S
authors: Maione
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D059350:Chronic Pain / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D059408:Pain Management; D011984:Sensory Receptor Cells / Q000502:physiology; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D000700:Analgesics; D050916:TRPV Cation Channels; C494484:TRPV1 receptor