title: Development and applications of a microfluidic reactor with multiple analytical probes.
abstract: We report the development of a versatile microfluidic (MF) reactor with multiple analytical probes, which can be used for (i) quantitative characterisation of molecular vibrational signatures of reactants or products, (ii) the localised real-time monitoring of temperature and (iii) site-specific measurements of pH of the reaction system. The analytical probes utilised for in situ reaction analysis include an ATR-FTIR probe, a temperature probe, and a pH probe. We demonstrate the applications of the MF reactor with integrated probes for the parallel monitoring of multiple variables in acid/base neutralisation reaction, of changes in buffer pH, temperature, and vibrational absorption bands, and for monitoring the kinetics of the reaction between CO(2) and a buffer system with therapeutic applications.
authors: Department of Chemistry, University of Toronto, 80 Saint George street, Toronto, Ontario M5S 3H6, Canada.
authors: Jesse
authors: J
authors: Greener
authors: Ethan
authors: E
authors: Tumarkin
authors: Michael
authors: M
authors: Debono
authors: Chi-Hang
authors: CH
authors: Kwan
authors: Milad
authors: M
authors: Abolhasani
authors: Axel
authors: A
authors: Guenther
authors: Eugenia
authors: E
authors: Kumacheva
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046210:Microfluidic Analytical Techniques; D018625:Microscopy, Atomic Force; D015335:Molecular Probes; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D015335:Molecular Probes; D002245:Carbon Dioxide