title: Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega.
abstract: To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).
authors: Disciplina de Patologia Especial, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, Abadia 38045-440 Uberaba, MG, Brazil.
authors: Eliângela de Castro
authors: Ede C
authors: Côbo
authors: Thales Parenti
authors: TP
authors: Silveira
authors: Adilha Misson
authors: AM
authors: Micheletti
authors: Eduardo
authors: E
authors: Crema
authors: Sheila Jorge
authors: SJ
authors: Adad