title: Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: a review of molecular mechanisms.
abstract: Sulfur mustard (SM) is a bifunctional alkylating agent with strong blistering, irritant, mutagenic and cytotoxic properties. SM has been widely deployed as a chemical warfare agent for over a century, leading to extensive casualties. Skin is among the first and most heavily damaged organs upon SM exposure. Unfortunately, a considerable fraction of SM-intoxicated patients are still suffering from chronic cutaneous complications. While these complications adversely affect patients' quality of life, there is as yet no ideal treatment for them and therapeutic options are limited and mainly symptomatic. During recent decades, remarkable progress has been made in understanding molecular mechanisms underlying SM-induced dermatotoxicity and several intra- and extracellular targets have been identified. This review argues that baicalin, a bioactive flavonoid from the roots of Scutellaria spp., could counteract different molecular and biochemical abnormalities that mediate SM dermatotoxicity and could therefore be regarded as a promising therapeutic option for the management of SM-induced cutaneous lesions.
authors: Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. sahebkarah811@mums.ac.ir
authors: Amirhossein
authors: A
authors: Sahebkar
mesh_terms: D020013:Calcium Signaling; D002619:Chemical Warfare Agents / Q000506:poisoning*; D004249:DNA Damage; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D020782:Matrix Metalloproteinases / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009151:Mustard Gas / Q000506:poisoning*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D011788:Quality of Life; D012871:Skin Diseases / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D002619:Chemical Warfare Agents; D005419:Flavonoids; D009569:Nitric Oxide; C038044:baicalin; D020928:Mitogen-Activated Protein Kinases; D020782:Matrix Metalloproteinases; D009151:Mustard Gas