title: Cytotoxic palladium(II) complexes of 8-aminoquinoline derivatives and the interaction with human serum albumin.
abstract: Palladium(II) complexes are potential antitumor metallodrugs for their chemical resemblance to platinum(II) complexes. Two palladium(II) complexes (1 and 2) in the formula of [PdL(n)Cl] [L(1) = N-(tert-butoxycarbonyl)-l-methionine-N'-8-quinolylamide, L(2) = L-alanine-N'-8-quinolylamide] have been synthesized accordingly. The structures of the complexes were fully characterized by X-ray crystallography. The palladium(II) center in 1 is coordinated by two N atoms and an S atom from L(1) with one chloride anion as the leaving group; while that in 2 is coordinated by three N atoms from L(2) with one chloride anion as the leaving group. The interaction between complex 1 and human serum albumin (HSA) has been investigated using fluorescence and circular dichroism spectroscopies. The complex seems to react with HSA chiefly through hydrophobic and electrostatic interactions, and it does not alter the α-helical nature of HSA. The cytotoxicity of these complexes has been tested against the human cervical cancer (HeLa), human mammary cancer (MCF-7), and human lung cancer (A-549) cell lines. Complex 1 displays a cytotoxic activity comparable to that of cisplatin, but complex 2 is less active than cisplatin.
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, PR China.
authors: Liangliang
authors: L
authors: Yan
authors: Xiaoyong
authors: X
authors: Wang
authors: Yanqing
authors: Y
authors: Wang
authors: Yangmiao
authors: Y
authors: Zhang
authors: Yizhi
authors: Y
authors: Li
authors: Zijian
authors: Z
authors: Guo
mesh_terms: D000465:Algorithms; D000634:Aminoquinolines / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics
chemical_list: D000634:Aminoquinolines; D009944:Organoplatinum Compounds; D012709:Serum Albumin; D010165:Palladium; C080436:8-aminoquinoline