title: New wrinkles in lipoprotein lipase biology.
abstract: OBJECTIVE
  We summarize recent progress on GPIHBP1, a molecule that transports lipoprotein lipase (LPL) to the capillary lumen, and discuss several newly studied molecules that appear important for the regulation of LPL activity.
  
  
  RESULTS
  LPL, the enzyme responsible for the lipolytic processing of triglyceride-rich lipoproteins, interacts with multiple proteins and is regulated at multiple levels. Several regulators of LPL activity have been known for years and have been investigated thoroughly, but several have been identified only recently, including an endothelial cell protein that transports LPL to the capillary lumen, a microRNA that reduces LPL transcript levels, a sorting protein that targets LPL for uptake and degradation, and a transcription factor that increases the expression of apolipoproteins that regulate LPL activity.
  
  
  CONCLUSIONS
  Proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues. Recent studies have identified GPIHBP1 as the molecule that transports LPL to the capillary lumen, and have also identified other molecules that are potentially important for regulating LPL activity. These new discoveries open new doors for understanding basic mechanisms of lipolysis and hyperlipidemia.
authors: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. bdavies@mednet.ucla.edu
authors: Brandon S J
authors: BS
authors: Davies
authors: Anne P
authors: AP
authors: Beigneux
authors: Loren G
authors: LG
authors: Fong
authors: Stephen G
authors: SG
authors: Young
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism; D008053:Lipid Mobilization; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D018110:Receptors, Lipoprotein
chemical_list: D001053:Apolipoproteins; D002352:Carrier Proteins; C523701:GPIHBP1 protein, human; D026502:LDL-Receptor Related Proteins; C532045:MIRN29a microRNA, human; D026901:Membrane Transport Proteins; D035683:MicroRNAs; D018110:Receptors, Lipoprotein; C102582:SORL1 protein, human; D008071:Lipoprotein Lipase