title: A case of hereditary angioedema involving recurrent abdominal attacks.
abstract: A 44-year-old Japanese woman was diagnosed with type 1 hereditary angioedema (HAE) at the age of 30. In March 2007, she began suffering from severe abdominal pain due to intestinal edema. After treatment with C1-INH concentrate, her symptoms disappeared. However, during the subsequent three years, the frequency of the attacks increased continuously, and C1-INH concentrate was necessary for treatment of every attack. The increase in the number of attacks might have been due to the frequent injection of C1-INH concentrate or the deterioration of her disease course. In a genetic investigation, the patient was found to have a novel mutation in the C1-INH gene.
authors: Department of Respiratory Medicine, Matsushita Memorial Hospital, Japan. kasamatsu.yoshihiro@jp.panasonic.com
authors: Yoshihiro
authors: Y
authors: Kasamatsu
authors: Kiyokazu
authors: K
authors: Yoshinoya
authors: Yu
authors: Y
authors: Kasamatsu
authors: Tetsuro
authors: T
authors: Yamamoto
authors: Takahiko
authors: T
authors: Horiuchi
authors: Masatoshi
authors: M
authors: Kadoya
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis* / Q000209:etiology*; D000328:Adult; D050718:Complement C1 Inhibitor Protein / Q000235:genetics / Q000627:therapeutic use; D005260:Female; D056829:Hereditary Angioedema Types I and II / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D012008:Recurrence
chemical_list: D050718:Complement C1 Inhibitor Protein