title: Serum levels of calcification inhibitors in patients with intracerebral hemorrhage.
abstract: The vascular calcification regulators and inflammatory markers including fetuin-A, osteopontin (OPN), and matrix Gla protein (MGP) may play an important role in the development of intracerebral hemorrhages (ICHs). So far, the relationship between these parameters and ICH has not been studied. Therefore, this study was designed to elucidate whether fetuin-A, MGP, and OPN are involved in the pathophysiology of ICH. The ICH group consisted of 27 consecutive patients with spontaneous ICH evaluated in the neurology intensive care unit within the first 24 hours from the onset of the stroke. The serum OPN levels were significantly increased in patients with ICH compared to the controls. On the other hand, the serum MGP and fetuin-A levels were significantly decreased in the patients with ICH in comparison to the controls. In the patients with ICH, the serum MGP levels of the nonsurvivors were statistically significantly lower than the MGP levels of the survivors. In conclusion, the change in serum fetuin-A, MGP, and OPN levels after ICH indicates that these parameters play a role in the pathophysiological processes leading to an ICH. Measurement of the serum MGP levels may also be of value to estimate mortality.
authors: Department of Neurology, School of Medicine, Dicle University, Diyarbakir, Turkey. drabdullahacar@hotmail.com
authors: Abdullah
authors: A
authors: Acar
authors: Mehmet Ugur
authors: MU
authors: Cevik
authors: Adalet
authors: A
authors: Arıkanoglu
authors: Osman
authors: O
authors: Evliyaoglu
authors: Mustafa Kemal
authors: MK
authors: Basarılı
authors: Ertugrul
authors: E
authors: Uzar
authors: Faysal
authors: F
authors: Ekici
authors: Yavuz
authors: Y
authors: Yucel
authors: Nebahat
authors: N
authors: Tasdemir
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002135:Calcium-Binding Proteins / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016326:Extracellular Matrix Proteins / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood; D011859:Radiography; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism; D000097568:Matrix Gla Protein
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D053495:Osteopontin; D060749:alpha-2-HS-Glycoprotein; D000097568:Matrix Gla Protein