title: Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowment.
abstract: 1. World-wide epidemiological and experimental animal studies demonstrate that adversity in fetal life, resulting in intrauterine growth restriction, programmes the offspring for a greater susceptibility to ischaemic heart disease and heart failure in adult life. 2. After cardiogenesis, cardiomyocyte endowment is determined by a range of hormones and signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of multinucleation/terminal differentiation. 3. The small fetus may have reduced cardiomyocyte endowment owing to the impact of a suboptimal intrauterine environment on the signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of terminal differentiation.
authors: Early Origins of Adult Health Research Group, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia.
authors: K J
authors: KJ
authors: Botting
authors: K C W
authors: KC
authors: Wang
authors: M
authors: M
authors: Padhee
authors: I C
authors: IC
authors: McMillen
authors: B
authors: B
authors: Summers-Pearce
authors: L
authors: L
authors: Rattanatray
authors: N
authors: N
authors: Cutri
authors: G S
authors: GS
authors: Posterino
authors: D A
authors: DA
authors: Brooks
authors: J L
authors: JL
authors: Morrison
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D004198:Disease Susceptibility; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006321:Heart / Q000196:embryology* / Q000503:physiopathology; D006331:Heart Diseases / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D032383:Myocytes, Cardiac / Q000473:pathology*; D038081:Organogenesis; D011123:Polyploidy; D011247:Pregnancy; D013045:Species Specificity