title: Bissilyl enal: a useful linchpin for synthesis of functionalized vinylsilane species by anion relay chemistry.
abstract: Bissilyl enal, prepared by a Mannich reaction of 3,3-bissilyl aldehyde with formaldehyde, has proven to be a useful linchpin in an efficient three-component coupling process. The reaction features a [1,4]-Brook rearrangement to generate the silylallyl anion, which adopts a predominant endo-orientation and can undergo addition to electrophiles in a regio- and stereoselective manner, giving various E-vinylsilane species in good yields.
authors: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
authors: Lu
authors: L
authors: Gao
authors: Xinglong
authors: X
authors: Lin
authors: Jian
authors: J
authors: Lei
authors: Zhenlei
authors: Z
authors: Song
authors: Zhi
authors: Z
authors: Lin
mesh_terms: D000838:Anions / Q000737:chemistry; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000138:chemical synthesis*
chemical_list: D000838:Anions; D012821:Silanes; D014753:Vinyl Compounds; C476909:vinylsilane