title: The effect of contrast medium SonoVue® on the electric charge density of blood cells.
abstract: The effect of contrast medium SonoVue® on the electric charge density of blood cells (erythrocytes and thrombocytes) was measured using a microelectrophoretic method. We examined the effect of adsorbed H⁺ and OH⁻ ions on the surface charge of erythrocytes or thrombocytes. Surface charge density values were determined from electrophoretic mobility measurements of blood cells performed at various pH levels. The interaction between solution ions and the erythrocyte's or thrombocyte's surface was described by a four-component equilibrium model. The agreement between the experimental and theoretical charge variation curves of the erythrocytes and thrombocytes was good at pH 2-9. The deviation observed at a higher pH may be caused by disregarding interactions between the functional groups of blood cells.
authors: Institute of Chemistry, University in Bialystok, Al. J. Pilsudskiego 11/4, 15-443 Bialystok, Poland. aneta@uwb.edu.pl
authors: Aneta D
authors: AD
authors: Petelska
authors: Jacek R
authors: JR
authors: Janica
authors: Joanna
authors: J
authors: Kotynska
authors: Urszula
authors: U
authors: Łebkowska
authors: Zbigniew A
authors: ZA
authors: Figaszewski
mesh_terms: D000328:Adult; D000465:Algorithms; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects*; D016022:Case-Control Studies; D003287:Contrast Media / Q000494:pharmacology*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects*; D005260:Female; D006391:Hemangioma / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007525:Isoelectric Focusing; D007526:Isoelectric Point; D008113:Liver Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D013459:Sulfur Hexafluoride / Q000494:pharmacology*; D013499:Surface Properties; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D003287:Contrast Media; D011933:Reagent Kits, Diagnostic; D013459:Sulfur Hexafluoride