title: The impact in the agnors expression and apoptosis in the prostate of hamster-mesocricetus auratus (HMA) submitted to finasteride application.
abstract: OBJECTIVE
  To evaluate the impact on the AgNORs expression and apoptosis in the prostate of the hamster-Mesocricetus auratus (HMA) submitted to the application of finasteride.
  
  
  METHODS
  Twenty male rodents of the species HMA (n = 20) were randomly assigned to groups of ten animals: Finasteride group (n = 10) and the Control group (n = 10). In the finasteride group 7.14 ng / mL finasteride was subcutaneously (SC) administered on the back of the animals three times a week for 90 days. AgNOR expression was evaluated as a marker of cell proliferation and apoptosis as a marker of cell death.
  
  
  RESULTS
  The expression of AgNORs was lower in the finasteride group, 2.846 ± 0.877 vs. 3.68 ± 1.07 argyrophilic regions per square micrometer (µm2) in the control group, p = <0.0001. Apoptosis was more frequent in the finasteride group, 53.62 ± 1.389 versus 14.76 ± 2.13 per µm2 in the control group, p = 0.0408.
  
  
  CONCLUSIONS
  We observed decreased expression of AgNORs and promotion of apoptosis in the prostate of rodents treated with finasteride.
authors: Brazilian Society of Urology. dimas@barbacena.com.br
authors: Dimas José Araújo
authors: DJ
authors: Vidigal
authors: Alcino Lázaro da
authors: AL
authors: Silva
authors: Felipe Eduardo Costa
authors: FE
authors: Vidigal
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000494:pharmacology*; D000818:Animals; D034961:Antigens, Nuclear / Q000096:biosynthesis* / Q000187:drug effects*; D017209:Apoptosis / Q000187:drug effects*; D006224:Cricetinae; D018120:Finasteride / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D011467:Prostate / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
chemical_list: D058891:5-alpha Reductase Inhibitors; D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins; D018120:Finasteride