title: Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation.
abstract: The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin = pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late-stage trifluoromethylation of a number of biologically active molecules.
authors: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors: Tianfei
authors: T
authors: Liu
authors: Xinxin
authors: X
authors: Shao
authors: Yaming
authors: Y
authors: Wu
authors: Qilong
authors: Q
authors: Shen
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D017611:Fluorine Compounds / Q000737:chemistry*; D054879:Halogenation; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D008745:Methylation
chemical_list: D017611:Fluorine Compounds; D006841:Hydrocarbons, Aromatic; D007495:Iridium; D003300:Copper