title: Hydrogen sulfide in the endocrine and reproductive systems.
abstract: Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce H(2)S, which regulates the local insulin sensitivity and vascular responsiveness. H(2)S also acts on the hypothalamic-pituitary-adrenal axis and is involved in stress responses. The effects of H(2)S on male and female reproductive function have also attracted great interest for their potential therapeutic implications in reproductive disorders. Alterations of H(2)S biosynthesis are associated with various endocrine disorders, and hormones can be important factors in the regulation of H(2)S production. Understanding the regulatory mechanisms for H(2)S synthesis pathways may help develop new therapeutic strategies.
authors: Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China.
authors: Xiao-Yan
authors: XY
authors: Zhu
authors: Hang
authors: H
authors: Gu
authors: Xin
authors: X
authors: Ni
mesh_terms: D000818:Animals; D004702:Endocrine Glands / Q000378:metabolism; D004703:Endocrine System / Q000378:metabolism*; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism; D012098:Reproduction / Q000502:physiology*
chemical_list: D006862:Hydrogen Sulfide