title: Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum.
abstract: We have investigated whether extremely low frequency magnetic field (ELF-MF) induces lipid peroxidation and reactive oxygen species in mouse cerebellum. After exposure to 60 Hz ELF-MF at 2.3 mT intensity for 3 hours, there was a significant increase in malondialdehyde level and hydroxyl radical. ELF-MF significantly induced concomitant increase in superoxide dismutase without alteration in glutathione peroxidase activity. While glutathione contents were not altered, ascorbic acid levels were significantly decreased by ELF-MF exposure. These results indicate that ELF-MF may induce oxidative stress in mouse cerebellum. However, the mechanism remains further to be characterized.
authors: Department of Pharmacology and Research Institute for Translational System Biomics, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, South Korea.
authors: Li Y
authors: LY
authors: Chu
authors: Jong H
authors: JH
authors: Lee
authors: Yun S
authors: YS
authors: Nam
authors: Yu J
authors: YJ
authors: Lee
authors: Won-Hee
authors: WH
authors: Park
authors: Byung-Cheon
authors: BC
authors: Lee
authors: Daejin
authors: D
authors: Kim
authors: Yoon H
authors: YH
authors: Chung
authors: Ji H
authors: JH
authors: Jeong
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002531:Cerebellum / Q000473:pathology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation; D060526:Magnetic Fields; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid