title: Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis.
abstract: Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.
authors: Department of Chemistry, Korea Military Academy, Seoul 139-799, South Korea. doas1mind@kma.ac.kr
authors: Keunhong
authors: K
authors: Jeong
authors: Hye Rim
authors: HR
authors: Cho
authors: Seung Hong
authors: SH
authors: Choi
authors: Yangki
authors: Y
authors: Park
authors: Pil Seok
authors: PS
authors: Chae
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D003035:Cobalt / Q000494:pharmacology*; D056831:Coordination Complexes / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000187:drug effects; D058228:Islet Amyloid Polypeptide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats
chemical_list: D056831:Coordination Complexes; D000080027:Cyclams; D006571:Heterocyclic Compounds; D058228:Islet Amyloid Polypeptide; D003035:Cobalt; D003300:Copper; C038072:cyclen