title: Central nervous system regeneration does not occur.
abstract: METHODS
  Review.
  
  
  OBJECTIVE
  To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site.
  
  
  METHODS
  Worldwide.
  
  
  METHODS
  A search of publications using 'PubMed' and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator.
  
  
  RESULTS
  There is no evidence for CNS regeneration.
  
  
  CONCLUSIONS
  A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
authors: Willow Pond House, Lymore Valley, Hampshire, UK. lee@illis.co.uk
authors: L S
authors: LS
authors: Illis
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000628:therapy; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends*