title: Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.
abstract: Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response. No ideal treatment exists. Triflusal is an antiplatelet salicylate derivative with anti-inflammatory effects. S-adenosylmethionine is a metabolic precursor for glutathione, an endogenous antioxidant. Dextromethorphan is a low-affinity N-methyl-D-aspartate receptor inhibitor. There is evidence that these agents modulate some of the pathways involved in I/R physiopathology. Intestinal I/R was induced in rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion. Rats either received saline or the drugs studied. At the end of the procedure, serum concentrations of tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined and intestinal morphology analyzed. I/R resulted in tissue damage, serum TNF-alpha and MDA elevations, and depletion of TAC. All drugs showed tissue protection. Only triflusal reduced TNF-alpha levels. All drugs lowered MDA levels, but only triflusal and S-adenosylmethionine maintained the serum TAC.
authors: Departamento de Fisiología, Facultad de Medicina, UANL, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Col. Mitras Centro, 64460 Monterrey, NL, Mexico. crcamara83@hotmail.com
authors: Carlos R
authors: CR
authors: Cámara-Lemarroy
authors: Francisco J
authors: FJ
authors: Guzmán-de la Garza
authors: Paula
authors: P
authors: Cordero-Pérez
authors: Gabriela
authors: G
authors: Alarcón-Galván
authors: Liliana
authors: L
authors: Torres-Gonzalez
authors: Linda E
authors: LE
authors: Muñoz-Espinosa
authors: Nancy E
authors: NE
authors: Fernández-Garza
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003915:Dextromethorphan / Q000627:therapeutic use*; D007422:Intestines / Q000098:blood supply*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000975:Antioxidants; D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; D014409:Tumor Necrosis Factor-alpha; C016167:triflusal; D008315:Malondialdehyde; D003915:Dextromethorphan; D012436:S-Adenosylmethionine