title: Mesna-induced photodistributed dermatosis.
abstract: We present the case of a 41-year-old man who developed a photodistributed eruption 1 month after being started on 2-mercaptoethane sulfonate sodium (mesna) for treatment of cyclophosphamide-induced haemorrhagic cystitis. The patient had a background history of Wegener granulomatosis, and had been taking cyclophosphamide at a stable dose of 150 mg daily for the previous 3 years. Complete resolution of the rash occurred within 8 weeks of cessation of mesna. This is the first reported case, to our knowledge, of mesna-induced photodistributed dermatosis. Early recognition of this condition will ensure prompt cessation of the culprit medication, and consideration of alternative management of haemorrhagic cystitis.
authors: Department of Dermatology, Canterbury District Health Board, Christchurch, New Zealand. cyf.trust@gmail.com
authors: C Y
authors: CY
authors: Lin
authors: M
authors: M
authors: Keefe
mesh_terms: D000328:Adult; D003556:Cystitis / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D015080:Mesna / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D020011:Protective Agents / Q000009:adverse effects*
chemical_list: D020011:Protective Agents; D015080:Mesna