title: Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis.
abstract: A phytochemical investigation of Monanthotaxis congoensis afforded eight polyoxygenated cyclohexenes as well as the known crotepoxide. Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells.
authors: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., St. Louis, MO 63114, United States. cstarks@sequoiasciences.com
authors: Courtney M
authors: CM
authors: Starks
authors: Russell B
authors: RB
authors: Williams
authors: Stephanie M
authors: SM
authors: Rice
authors: Vanessa L
authors: VL
authors: Norman
authors: Julie A
authors: JA
authors: Lawrence
authors: Matt G
authors: MG
authors: Goering
authors: Mark
authors: M
authors: O'Neil-Johnson
authors: Jin-Feng
authors: JF
authors: Hu
authors: Gary R
authors: GR
authors: Eldridge
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D053138:Cyclohexenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053138:Cyclohexenes; D004852:Epoxy Compounds; D010936:Plant Extracts; C011828:futoxide