title: Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population.
abstract: A recent genome-wide association study of renal cell carcinoma (RCC) in European population has identified genetic variants in the regions of 2p21 (rs7579899), 11q13.3 (rs7105934) and 12q24.31 (rs4765623) conferred susceptibility to RCC. In our study, we assessed whether these polymorphisms are also associated with RCC risk in a Chinese population. We genotyped these polymorphisms using TaqMan method and assessed their associations with RCC risk in a case-control study of 710 patients with histologically confirmed RCC and 760 cancer-free controls. Normal renal tissues adjacent to tumors were used to evaluate the functional consequences of these polymorphisms. We found that rs7105934 was significantly associated with reduced RCC risk [adjusted odds ratio (OR) = 0.67, 95% confidence intervals (CIs) = 0.47-0.95, GA+AA versus GG], particularly among subgroups of normal-weight individuals (OR = 0.51, 95%CI = 0.29-0.88), never-smokers (OR = 0.53, 95%CI = 0.33-0.85) and non-drinkers (OR = 0.57, 95%CI = 0.370.87). Furthermore, the rs7105934 GA genotype was associated with lower levels of CCND1 mRNA compared with GG genotype, although this association was only marginally significant (P = 0.055). No significant association between rs7579899 or rs7105934 and RCC risk was observed. Our results suggest that rs7105934 on 11q13.3 may confer susceptibility to RCC in our population. Large population-based prospective and functional studies are required to validate the associations between these loci and RCC risk.
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Qiang
authors: Q
authors: Cao
authors: Chao
authors: C
authors: Qin
authors: Xiaobing
authors: X
authors: Ju
authors: Xiaoxin
authors: X
authors: Meng
authors: Meilin
authors: M
authors: Wang
authors: Jian
authors: J
authors: Zhu
authors: Pu
authors: P
authors: Li
authors: Jiawei
authors: J
authors: Chen
authors: Zhengdong
authors: Z
authors: Zhang
authors: Changjun
authors: C
authors: Yin
mesh_terms: D044466:Asian People; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D051122:Scavenger Receptors, Class B / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019938:Cyclin D1; D011518:Proto-Oncogene Proteins; D051122:Scavenger Receptors, Class B; D000099162:Endothelial PAS Domain-Containing Protein 1; C530104:CCND1 protein, human; C407245:MYEOV protein, human; C495124:SCARB1 protein, human