title: Therapeutic potential of new hydrogen sulfide-releasing hybrids.
abstract: A new class of hydrogen sulfide (H(2)S)-donating hybrids combined with pharmacologically active compounds is presented in this article. The pharmacological profiles of some hybrid lead compounds in the areas of inflammation, H(2)S-donating diclofenac (ACS 15); cardiovascular, H(2)S-donating aspirin (ACS 14); urology, H(2)S-donating sildenafil (ACS 6); and neurodegenerative, H(2)S-donating latanoprost (ACS 67) for glaucoma treatment and H(2)S-donating levodopa (ACS 84) for Parkinson's disease, are described. The new H(2)S-releasing hybrids demonstrate remarkable improvement in activity and tolerability as compared with the related parent compounds, suggesting an active pharmacological role for H(2)S. Finally the mechanism(s) of action of glutathione-dependent and independent, and of gas (H(2)S) release (spontaneous or enzymatic) and its implications for clinical pharmacology perspectives will be also discussed.
authors: Department of Pharmaceutical Science "Pietro Pratesi", Università degli Studi di Milano, Via Mangiagalli, 25-20133 Milano, Italy. anna.sparatore@unimi.it
authors: Anna
authors: A
authors: Sparatore
authors: Giancarlo
authors: G
authors: Santus
authors: Daniela
authors: D
authors: Giustarini
authors: Ranieri
authors: R
authors: Rossi
authors: Piero
authors: P
authors: Del Soldato
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D004008:Diclofenac / Q000008:administration & dosage; D006801:Humans; D006862:Hydrogen Sulfide / Q000008:administration & dosage* / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D000077338:Latanoprost; D007980:Levodopa / Q000008:administration & dosage; D011355:Prodrugs / Q000008:administration & dosage; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011355:Prodrugs; D011461:Prostaglandins F, Synthetic; D004008:Diclofenac; D007980:Levodopa; D000077338:Latanoprost; D001241:Aspirin; D006862:Hydrogen Sulfide