title: Adhesion prevention in patients with multiple cesarean deliveries.
abstract: Adhesion formation is a well-known complication of abdominal surgery. Although one third of all deliveries in the United States are by cesarean delivery (CD), little is known about adhesions in the obstetric setting. Various surgical techniques for reducing adhesion formation following CD have been investigated. The relative benefits of peritoneal closure and single-layer uterine closure are areas of continued research and debate. Adhesion prevention products are also becoming more commonplace in gynecologic surgery. Two membrane/adhesion barriers have been approved in the United States. A barrier consisting of oxidized regenerated cellulose (Interceed absorbable adhesion barrier) has been shown to reduce adhesions during microsurgery. Its use may be limited following CD because complete hemostasis is crucial to its efficacy. Seprafilm adhesion barrier, composed of hyaluronic acid and carboxymethylcellulose, is approved for use in abdominal or pelvic laparotomy. Preliminary data suggest that it may be effective for reducing adhesions following CD. This article discusses what is currently known about adhesion prevention in the obstetric population and highlights the paucity of level I evidence available to clinicians in this setting.
authors: Department of Obstetrics and Gynecology, University of Alabama-Birmingham, Birmingham, AL 35233, USA. wbates@uab.edu
authors: Gordon Wright
authors: GW
authors: Bates
authors: Stacy
authors: S
authors: Shomento
mesh_terms: D002266:Carboxymethylcellulose Sodium; D002482:Cellulose; D002483:Cellulose, Oxidized; D002585:Cesarean Section / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D017604:Cesarean Section, Repeat / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid; D008567:Membranes, Artificial; D010537:Peritoneum / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D011247:Pregnancy; D012307:Risk Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED; D008567:Membranes, Artificial; C118198:Seprafilm; D002482:Cellulose; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium