title: Target of γ-secretase modulators, presenilin marks the spot.
authors: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Christina J
authors: CJ
authors: Crump
authors: Douglas S
authors: DS
authors: Johnson
authors: Yue-Ming
authors: YM
authors: Li
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D053764:Presenilin-1; D011487:Protein Conformation / Q000187:drug effects*
chemical_list: D016229:Amyloid beta-Peptides; C508853:PSEN1 protein, human; D010446:Peptide Fragments; D010880:Piperidines; D053764:Presenilin-1; C078639:amyloid beta-protein (1-38); C075222:amyloid beta-protein (1-42); D053829:Amyloid Precursor Protein Secretases