title: Genome-wide association study of vascular dementia.
abstract: OBJECTIVE
  Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia.
  
  
  METHODS
  We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples.
  
  
  RESULTS
  In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 ± 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 × 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).
  
  
  CONCLUSIONS
  Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required.
authors: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors: Elisabeth M C
authors: EM
authors: Schrijvers
authors: Britta
authors: B
authors: Schürmann
authors: Peter J
authors: PJ
authors: Koudstaal
authors: Hendrik
authors: H
authors: van den Bussche
authors: Cornelia M
authors: CM
authors: Van Duijn
authors: Frank
authors: F
authors: Hentschel
authors: Reinhard
authors: R
authors: Heun
authors: Albert
authors: A
authors: Hofman
authors: Frank
authors: F
authors: Jessen
authors: Heike
authors: H
authors: Kölsch
authors: Johannes
authors: J
authors: Kornhuber
authors: Oliver
authors: O
authors: Peters
authors: Fernando
authors: F
authors: Rivadeneira
authors: Eckart
authors: E
authors: Rüther
authors: André G
authors: AG
authors: Uitterlinden
authors: Steffi
authors: S
authors: Riedel-Heller
authors: Martin
authors: M
authors: Dichgans
authors: Jens
authors: J
authors: Wiltfang
authors: Wolfgang
authors: W
authors: Maier
authors: Monique M B
authors: MM
authors: Breteler
authors: M Arfan
authors: MA
authors: Ikram
mesh_terms: D000368:Aged; D000483:Alleles; D002877:Chromosomes, Human / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D015140:Dementia, Vascular / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D055106:Genome-Wide Association Study; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D011153:Population; D011944:Receptors, Androgen / Q000235:genetics; D012737:Sex Factors
chemical_list: D011944:Receptors, Androgen; D004247:DNA