title: The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study.
abstract: BACKGROUND
  Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization.
  
  
  METHODS
  Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis.
  
  
  RESULTS
  The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin.
  
  
  CONCLUSIONS
  As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: Z
authors: Z
authors: Wang
authors: T
authors: T
authors: Jiang
authors: S
authors: S
authors: Sauro
authors: D H
authors: DH
authors: Pashley
authors: M
authors: M
authors: Toledano
authors: R
authors: R
authors: Osorio
authors: S
authors: S
authors: Liang
authors: W
authors: W
authors: Xing
authors: Y
authors: Y
authors: Sa
authors: Y
authors: Y
authors: Wang
mesh_terms: D000328:Adult; D002118:Calcium / Q000032:analysis; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D005898:Glass; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000032:analysis; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014089:Tooth Remineralization / Q000379:methods*; D014100:Toothpastes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D057133:Dentin Desensitizing Agents; C510984:NovaMin; D010710:Phosphates; D014100:Toothpastes; D002118:Calcium