title: Subversion of membrane transport pathways by vacuolar pathogens.
abstract: Mammalian phagocytes control bacterial infections effectively through phagocytosis, the process by which particles engulfed at the cell surface are transported to lysosomes for destruction. However, intracellular pathogens have evolved mechanisms to avoid this fate. Many bacterial pathogens use specialized secretion systems to deliver proteins into host cells that subvert signaling pathways controlling membrane transport. These bacterial effectors modulate the function of proteins that regulate membrane transport and alter the phospholipid content of membranes. Elucidating the biochemical function of these effectors has provided a greater understanding of how bacteria control membrane transport to create a replicative niche within the host and provided insight into the regulation of membrane transport in eukaryotic cells.
authors: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
authors: Eric
authors: E
authors: Alix
authors: Shaeri
authors: S
authors: Mukherjee
authors: Craig R
authors: CR
authors: Roy
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001424:Bacterial Infections / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism; D015398:Signal Transduction; D014617:Vacuoles / Q000378:metabolism*
chemical_list: D058947:Bacterial Secretion Systems; D026901:Membrane Transport Proteins; D010743:Phospholipids; D020558:GTP Phosphohydrolases