title: Regulating inflammation: ADAM8--a new player in the game.
abstract: Leukocyte recruitment to sites of inflammation proceeds in a cascade-like fashion. However, it is less clear how the complex interactions among the different adhesion molecules involved in this process are coordinately regulated. A report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2011. 41: 3436-3442] shows that ADAM8 may participate in the control of the adhesion molecule P-selectin glycoprotein ligand 1. This finding suggests a new role for ADAM8 in the regulation of inflammatory processes.
authors: Department of Anesthesiology and Critical Care Medicine, University of Münster, Münster, Germany. zarbock@uni-muenster.de
authors: Alexander
authors: A
authors: Zarbock
authors: Jan
authors: J
authors: Rossaint
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D019038:Platelet Glycoprotein GPIb-IX Complex; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C086680:ETV5 protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C084882:P-selectin ligand protein; D019038:Platelet Glycoprotein GPIb-IX Complex; D014157:Transcription Factors; C094990:adhesion receptor; D051722:ADAM Proteins; C068490:ADAM8 protein, human