title: Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo.
abstract: Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association. With four regression models obtained, two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 locus were associated with psoriasis. More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.
authors: Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Kun-Ju
authors: KJ
authors: Zhu
authors: Yong-Mei
authors: YM
authors: Lv
authors: Xian-Yong
authors: XY
authors: Yin
authors: Zai-Xing
authors: ZX
authors: Wang
authors: Liang-Dan
authors: LD
authors: Sun
authors: Su-Min
authors: SM
authors: He
authors: Hui
authors: H
authors: Cheng
authors: Da-Yan
authors: DY
authors: Hu
authors: Zheng
authors: Z
authors: Zhang
authors: Yang
authors: Y
authors: Li
authors: Xian-Bo
authors: XB
authors: Zuo
authors: You-Wen
authors: YW
authors: Zhou
authors: Sen
authors: S
authors: Yang
authors: Xing
authors: X
authors: Fan
authors: Xue-Jun
authors: XJ
authors: Zhang
authors: Feng-Yu
authors: FY
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D012044:Regression Analysis; D014820:Vitiligo / Q000235:genetics*; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; C103596:HLA-DQA2 antigen