title: Long-lasting TMS motor threshold elevation in mild traumatic brain injury.
abstract: OBJECTIVE
  Mild traumatic brain injury (mTBI) is very common, and part of the patients experience persistent symptoms. These may be caused by diffuse neuronal damage and could therefore affect cortical excitability. The motor threshold (MT), measured by transcranial magnetic stimulation (TMS), is a measure of cortical excitability and cortico-spinal tract integrity.
  
  
  METHODS
  We used navigated TMS (nTMS) and electromyography to determine subjects' left hemisphere MTs. Nineteen subjects with mTBI (11 with persistent symptoms and eight fully recovered) and nine healthy controls were tested. The injuries had occurred on average 5 years earlier. All participants had normal brain MRIs, that is, no signs of injury. None used centrally acting medication.
  
  
  RESULTS
  The mean MT in controls was 43.0% (SD 2.5) of maximum stimulator output. The mTBI subjects mean MT was 53.4% (SD 9.7), being higher than the controls' threshold. Subjective recovery did not correlate with MT.
  
  
  CONCLUSIONS
  The results show chronic MT elevation in a sample of subjects with symptomatic or recovered mTBI. This suggests that mTBI may be compensated, although not fully recovered, years after the injury. While the cause for MT elevation cannot be concluded from these preliminary observations, possible explanations include decreased cortical excitability and impaired subcortical conduction.
authors: Centre for Cognitive Neuroscience, Department of Psychology, University of Turku, Finland. jptall@utu.fi
authors: J
authors: J
authors: Tallus
authors: P
authors: P
authors: Lioumis
authors: H
authors: H
authors: Hämäläinen
authors: S
authors: S
authors: Kähkönen
authors: O
authors: O
authors: Tenovuo
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D011712:Pyramidal Tracts / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult