title: Nuclear phospholipase C in biological control and cancer.
abstract: Inositol lipids are key regulators of several cellular functions. The identification of an independent nuclear polyphosphoinositides signaling machinery has led the way to find new roles for these molecules. PI-PLC-β1 is the most extensively studied PLC isoform in the nuclear compartment and a key player in the regulation of nuclear lipid signaling. Nuclear PI-PLC-β1 is involved in cell cycle progression and differentiation in response to growth factor stimulation. A growing body of evidence has demonstrated that nuclear phosphoinositides are also involved in cancer cell generation, proliferation, and resistance to apoptosis. Evidence on ex vivo human cancer cells from patients with myelodysplastic syndromes (MDS) confirmed these observations, suggesting the involvement of PI-PLC-β1 both in the pathogenesis of the disease and in the progression of MDS to acute myeloid leukemia. These studies have offered new targets for the development of novel therapeutic strategies as well as new prognostic tools.
authors: Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy.
authors: Giulia
authors: G
authors: Ramazzotti
authors: Irene
authors: I
authors: Faenza
authors: Matilde Y
authors: MY
authors: Follo
authors: Roberta
authors: R
authors: Fiume
authors: Manuela
authors: M
authors: Piazzi
authors: Roberto
authors: R
authors: Giardino
authors: Milena
authors: M
authors: Fini
authors: Lucio
authors: L
authors: Cocco
mesh_terms: D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D010716:Phosphatidylinositols; D010738:Type C Phospholipases