title: The genetics and cell biology of fertilization.
abstract: Although the general events surrounding fertilization in many species are well described, the molecular underpinnings of fertilization are still poorly understood. Caenorhabditis elegans has emerged as a powerful model system for addressing the molecular and cell biological mechanism of fertilization. A primary advantage is the ability to isolate and propagate mutants that effect gametes and no other cells. This chapter provides conceptual guidelines for the identification, maintenance, and experimental approaches for the study fertility mutants.
authors: Waksman Institute, Rutgers University, Department of Microbiology and Molecular Genetics, Piscataway, New Jersey, USA.
authors: Brian D
authors: BD
authors: Geldziler
authors: Matthew R
authors: MR
authors: Marcello
authors: Diane C
authors: DC
authors: Shakes
authors: Andrew
authors: A
authors: Singson
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics* / Q000502:physiology; D003585:Cell Biology; D005260:Female; D005298:Fertility; D005306:Fertilization / Q000235:genetics; D005718:Gametogenesis; D007246:Infertility / Q000235:genetics; D008297:Male; D009154:Mutation; D009865:Oocytes / Q000502:physiology; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology