title: Association between the PPARG gene polymorphism and the risk of diabetic nephropathy: a meta-analysis.
abstract: BACKGROUND
  The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene is suggested to associate with diabetic nephropathy.
  
  
  OBJECTIVE
  A meta-analysis was conducted to investigate the potential association of PPARG gene polymorphisms with susceptibility to diabetic nephropathy.
  
  
  METHODS
  A comprehensive search of MEDLINE (1966 to June 2011) was conducted to identify published epidemiologic studies related to polymorphisms of the PPARG gene and diabetic nephropathy. A database search yielded 5 studies involving 2758 patients. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.
  
  
  RESULTS
  The combined results based on all studies showed no significant difference in genotype distribution (Pro/Pro: OR. 1.42, 95% CI, 0.96-2.09); Pro/Ala: OR, 0.74, 95% CI, 0.50-1.10; Ala/Ala: OR, 0.85, 95% CI, 0.52-1.38) between cases and controls. After stratification for race, results were similar except that patients with diabetic nephropathy had a significantly higher frequency of Pro/Pro (OR, 1.82; 95% CI, 1.17-2.85) than controls among Asians.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the Pro12Ala polymorphism of the PPARG gene may be associated with diabetic nephropathy among Asians.
authors: Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
authors: RuiChao
authors: R
authors: Yu
authors: Hong
authors: H
authors: Bo
authors: SongMing
authors: S
authors: Huang
mesh_terms: D044466:Asian People / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D047495:PPAR gamma