title: The relationship between the change in serum high sensitivity C-reactive protein levels and IVF success.
abstract: The aim of this study was to assess whether the extent of the change in high sensitivity C-reactive protein (hs-CRP) levels is related with in vitro fertilization (IVF) success. A total of 69 IVF cycles using long luteal GnRH agonist protocol at the IVF unit, were prospectively studied. The serum levels of hs-CRP were measured on the day of initiation of gonadotrophin stimulation and 7 days after embryo transfer. CRP ratio was defined as the levels of CRP on day 7 of transfer/day of initiation of ovarian stimulation. Clinical pregnancy rates were examined. The mean concentrations of hs-CRP were not significantly different on the first day of ovarian stimulation and on day 7 after embryo transfer among pregnant and non-pregnant women. There was a significant rise in hs-CRP levels at 7th day after embryo transfer as compared with the first day of gonadotrophin treatment in both groups (10.58 ± 11.35 versus 3.61 ± 2.86 mg/L for pregnant women and 9.14 ± 11.36 versus 3.24 ± 2.68 mg/L for non-pregnant women, p = 0.001). In addition, the mean CRP ratio was not different between the pregnant and non-pregnant groups. Our data show that serum hs-CRP levels increase during IVF treatment, but the extent of the rise in CRP levels is not a predictive marker of IVF success.
authors: Department of Reproductive Endocrinology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey. bernaseckin1@hotmail.com
authors: Berna
authors: B
authors: Seckin
authors: Gulnur
authors: G
authors: Ozaksit
authors: Sertac
authors: S
authors: Batioglu
authors: Murat
authors: M
authors: Ozel
authors: Munube
authors: M
authors: Aydoğan
authors: Bahar
authors: B
authors: Senturk
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D013379:Substrate Specificity; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein