title: Sexual function of patients with schizophrenia receiving first-generation (FGA) or second-generation antipsychotic (SGA) treatment.
abstract: OBJECTIVE
  The aim of the study was to investigate sexual function in patients with schizophrenia receiving treatment with a first-generation antipsychotic (FGA) or a second-generation antipsychotic (SGA) drug. Sexual function is an important aspect of human experience, which can be affected by antipsychotic drug treatment. Sexual dysfunction in patients with schizophrenia may be less prevalent with SGA than with FGA drug treatment.
  
  
  METHODS
  A cross-sectional prevalence study assessed sexual function in a sample of 144 patients with DSM-IV schizophrenia aged between 18 and 65, using the Derogatis Interview for Sexual Functioning (self-report version: DISF-SR). Two equal-sized groups (N = 72) received treatment with an FGA or an SGA drug for at least 12 weeks.
  
  
  RESULTS
  No significant differences were seen on DISF-SR total score or subscale score between the two treatment groups.
  
  
  CONCLUSIONS
  There are no differences in measured sexual function of non-randomised patients with schizophrenia treated with an FGA compared with SGA-treated patients.
authors: Mental Health & Neurodegeneration Research Group, School of Community Based Medicine, The University of Manchester, Manchester, UK.
authors: Ahmed
authors: A
authors: Mahmoud
authors: Karen P
authors: KP
authors: Hayhurst
authors: Richard J
authors: RJ
authors: Drake
authors: Shôn W
authors: SW
authors: Lewis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D057566:Self Report; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents