title: Resident cardiac stem cells.
abstract: The introduction of stem cells in cardiology provides new tools in understanding the regenerative processes of the normal and pathologic heart and opens new options for the treatment of cardiovascular diseases. The feasibility of adult bone marrow autologous and allogenic cell therapy of ischemic cardiomyopathies has been demonstrated in humans. However, many unresolved questions remain to link experimental with clinical observations. The demonstration that the heart is a self-renewing organ and that its cell turnover is regulated by myocardial progenitor cells offers novel pathogenetic mechanisms underlying cardiac diseases and raises the possibility to regenerate the damaged heart. Indeed, cardiac stem progenitor cells (CSPCs) have recently been isolated from the human heart by several laboratories although differences in methodology and phenotypic profile have been described. The present review points to the potential role of CSPCs in the onset and development of congestive heart failure and its reversal by regenerative approaches aimed at the preservation and expansion of the resident pool of progenitors.
authors: Department of Internal Medicine and Biomedical Science University Hospital of Parma, 43100 Parma, Italy.
authors: C
authors: C
authors: Frati
authors: M
authors: M
authors: Savi
authors: G
authors: G
authors: Graiani
authors: C
authors: C
authors: Lagrasta
authors: S
authors: S
authors: Cavalli
authors: L
authors: L
authors: Prezioso
authors: P
authors: P
authors: Rossetti
authors: C
authors: C
authors: Mangiaracina
authors: F
authors: F
authors: Ferraro
authors: D
authors: D
authors: Madeddu
authors: E
authors: E
authors: Musso
authors: D
authors: D
authors: Stilli
authors: A
authors: A
authors: Rossini
authors: A
authors: A
authors: Falco
authors: A De
authors: AD
authors: Angelis
authors: F
authors: F
authors: Rossi
authors: K
authors: K
authors: Urbanek
authors: A
authors: A
authors: Leri
authors: J
authors: J
authors: Kajstura
authors: P
authors: P
authors: Anversa
authors: E
authors: E
authors: Quaini
authors: F
authors: F
authors: Quaini
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D009202:Cardiomyopathies / Q000628:therapy*; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D006321:Heart / Q000502:physiology*; D006801:Humans; D017202:Myocardial Ischemia / Q000628:therapy*; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D016896:Treatment Outcome