title: Amlodipine-induced petechial rash.
abstract: A patient of essential hypertension stabilized on 10 mg amlodipine once daily developed brownish black petechial non-blanching macular rash bilaterally covering the limbs below the knee and dorsum of the feet. History, general and clinical examinations and lab investigations revealed no abnormalities. Temporal association of the onset of rash with amlodipine use, inability to explain rash by natural history of hypertension, possibility of rash with amlodipine and rash resolution on dechallenge placed this reaction in Naranjo score of 6, a probable adverse reaction to amlodipine. Hence the drug was replaced by enalapril. The rash resolved completely over a period of eight weeks.
authors: Department of Pharmacology, Government Medical College, Pandharpur Road, Miraj, Maharashtra, India. mangala.bhaskar@gmail.com
authors: M B
authors: MB
authors: Murthy
authors: B
authors: B
authors: Murthy
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011693:Purpura / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine