title: Regulation of RAGE for attenuating progression of diabetic vascular complications.
abstract: Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease.
authors: Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan.
authors: Myat Thu Thu
authors: MT
authors: Win
authors: Yasuhiko
authors: Y
authors: Yamamoto
authors: Seiichi
authors: S
authors: Munesue
authors: Hidehito
authors: H
authors: Saito
authors: Dong
authors: D
authors: Han
authors: So
authors: S
authors: Motoyoshi
authors: Tarek
authors: T
authors: Kamal
authors: Takuro
authors: T
authors: Ohara
authors: Takuo
authors: T
authors: Watanabe
authors: Hiroshi
authors: H
authors: Yamamoto
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D003925:Diabetic Angiopathies / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D003928:Diabetic Nephropathies / Q000209:etiology; D003929:Diabetic Neuropathies / Q000209:etiology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000502:physiology; D006801:Humans; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic