title: Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.
abstract: MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized expression (DP) group were 50 (39.7%), 35 (27.8%), and 41 (32.5%), respectively. Depolarized MUC1 expression was significantly associated with poor outcome and was closely correlated with glucose metabolism (Glut1), hypoxia (HIF-1α), angiogenesis (vascular endothelial growth factor and microvessel density), amino acid metabolism (LAT1), and EGFR expression. High-grade polarized MUC1 expression was associated with favorable prognosis and adenocarcinoma. Depolarized MUC1 expression was significantly associated with poor outcome. Glucose metabolism, hypoxia, angiogenesis, amino acid metabolism, and EGFR pathway may play an important role in the development of depolarized MUC1 expression.
authors: Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan. kkaira1970@yahoo.co.jp
authors: Kyoichi
authors: K
authors: Kaira
authors: Kazuo
authors: K
authors: Nakagawa
authors: Yasuhisa
authors: Y
authors: Ohde
authors: Takehiro
authors: T
authors: Okumura
authors: Toshiaki
authors: T
authors: Takahashi
authors: Haruyasu
authors: H
authors: Murakami
authors: Masahiro
authors: M
authors: Endo
authors: Haruhiko
authors: H
authors: Kondo
authors: Takashi
authors: T
authors: Nakajima
authors: Nobuyuki
authors: N
authors: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015687:Cell Hypoxia; D066246:ErbB Receptors / Q000096:biosynthesis; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000096:biosynthesis*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015398:Signal Transduction / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1; C512478:EGFR protein, human; D066246:ErbB Receptors