title: Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors.
abstract: Blockade of the renin-angiotensin system (RAS) is well recognized as an essential therapy in hypertensive, heart, and kidney diseases. There are several classes of drugs that block the RAS; these drugs are known to exhibit antifibrotic action. An analysis of the molecular mechanisms of action for these drugs can reveal potential differences in their antifibrotic roles. In this review, we discuss the antifibrotic action of RAS blockade with an emphasis on the potential importance of angiotensin I-converting enzyme (ACE) inhibition associated with the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP).
authors: Division of Diabetes & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan. kkanasak@kanazawa-med.ac.jp.
authors: Megumi
authors: M
authors: Kanasaki
authors: Takako
authors: T
authors: Nagai
authors: Munehiro
authors: M
authors: Kitada
authors: Daisuke
authors: D
authors: Koya
authors: Keizo
authors: K
authors: Kanasaki