title: [Association of polymorphic markers of CCL2 gene with essential hypertension].
abstract: Chemokine CCL2, or monocytic chemoatractant protein 1 (CCL2/MCP-1) plays an important role in the development of cardiovascular diseases. In the present study, genotypes of four polymorphic markers (rs1860190, rs1024611, rs3917887, and rs991804) of the CCL2gene were identified in the population of Tatars (residents of the Republic of Bashkortostan). Analysis of associations of these markers with essential hypertension (EH) was carried out. It was demonstrated that haplotype CCL2*A*G*D*T was associated with the increased risk of EH (P = 0.01; OR = 1.53).
authors: T R
authors: TR
authors: Nasibullin
authors: V A
authors: VA
authors: Belonogova
authors: I A
authors: IA
authors: Tuktarova
authors: I E
authors: IE
authors: Nikolaeva
authors: I M
authors: IM
authors: Karamova
authors: O E
authors: OE
authors: Mustafina
mesh_terms: D000328:Adult; D001486:Bashkiria; D018932:Chemokine CCL2 / Q000235:genetics*; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005819:Genetic Markers