title: Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity.
abstract: Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.
authors: Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom. p.wulff@abdn.ac.uk
authors: Peer
authors: P
authors: Wulff
authors: Benjamin R
authors: BR
authors: Arenkiel
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D005821:Genetic Techniques; D006801:Humans; D008024:Ligands; D009474:Neurons / Q000502:physiology*; D009488:Neurosciences / Q000379:methods* / Q000639:trends
chemical_list: D008024:Ligands