title: Asymmetric synthesis of sulfinamides using (-)-quinine as chiral auxiliary.
abstract: A process has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as auxiliary. A variety of chiral sulfinamides including N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselectivity starting from easily available and inexpensive reagents. The auxiliary quinine could be recovered and recycled.
authors: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States. yongda.zhang@boehringer-ingelheim.com
authors: Yongda
authors: Y
authors: Zhang
authors: Sampada
authors: S
authors: Chitale
authors: Navneet
authors: N
authors: Goyal
authors: Guisheng
authors: G
authors: Li
authors: Zhengxu S
authors: ZS
authors: Han
authors: Sherry
authors: S
authors: Shen
authors: Shengli
authors: S
authors: Ma
authors: Nelu
authors: N
authors: Grinberg
authors: Heewon
authors: H
authors: Lee
authors: Bruce Z
authors: BZ
authors: Lu
authors: Chris H
authors: CH
authors: Senanayake
mesh_terms: D007202:Indicators and Reagents / Q000737:chemistry; D015394:Molecular Structure; D011803:Quinine / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013452:Sulfonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D013449:Sulfonamides; D013452:Sulfonium Compounds; D011803:Quinine