title: Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease.
abstract: Abnormal immunological responses to certain microbial agents may play a crucial role in the pathogenesis of Kawasaki disease (KD). The association studies between histo-blood group genes (Lewis and ABO blood types) and various types of infectious diseases or vasculopathy have been carried out based on the fact that glycosylated antigens could directly mediate microbial infections. We attempted to clarify the role of blood type antigens in the development of KD and coronary artery lesions in KD patients. The subjects included 164 KD patients enrolled from 1998 to 2003 (1st group), 232 patients from 2004 to 2009 (2nd group), and 223 healthy children and 118 patients with growth hormone deficiency as controls. The genotyping of the FUT2 and FUT3 genes, and ABO genotypes, was determined with the TaqMan SNP assay and allele-specific polymerase chain reaction. No significant differences were observed in the genotypes and allele frequencies of the FUT2 and FUT3 genes between the groups. The frequency of the BB blood genotype was significantly higher in KD patients with coronary artery lesions in the 1st and 2nd groups than in the controls (17% and 14% vs. 5%, P = 0.0020). This is the first report to investigate the roles of ABO and Lewis blood types in the development of KD, and in the formation of coronary artery lesions in KD patients. These data suggest that the ABO blood type may play a role in the development of coronary artery lesions in KD patients.
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. yamamura@pediatr.med.kyushu-u.ac.jp
authors: K
authors: K
authors: Yamamura
authors: K
authors: K
authors: Ihara
authors: K
authors: K
authors: Ikeda
authors: H
authors: H
authors: Nagata
authors: Y
authors: Y
authors: Mizuno
authors: T
authors: T
authors: Hara
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D007223:Infant; D007983:Lewis Blood Group Antigens / Q000235:genetics; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000235:genetics / Q000473:pathology; D011110:Polymorphism, Genetic; D012621:Seasons; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D000017:ABO Blood-Group System; D005647:Fucosyltransferases; D007983:Lewis Blood Group Antigens; D000097631:Galactoside 2-alpha-L-fucosyltransferase; C019818:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase