title: Seizure recency and quality of life in adolescents with childhood-onset epilepsy.
abstract: Health-related quality of life (HRQOL) is associated with seizure recency among adults with epilepsy. In a prospective, community-based study of long-term outcomes of childhood-onset epilepsy, we evaluated whether worse HRQOL is associated with more recent seizures among children and adolescents with epilepsy. We used the Child Health Questionnaire (CHQ), a generic measure with child and parent-proxy versions, to measure HRQOL. Among 277 children with epilepsy (CWE) assessed 9 years after diagnosis, parent-proxy reported but not child self-reported HRQOL was significantly worse for those having seizures in the prior year than for those who were seizure free ≥1 year across the majority of scales. There were no differences between CWE in remission for 1-5 years and those seizure free ≥5 years for child and parent-proxy reported HRQOL with the exception of the parent Emotional Impact scale, suggesting that HRQOL differences related to seizure recency level off after the initial year of remission.
authors: Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA. cbower@mednet.ucla.edu
authors: Christine B
authors: CB
authors: Baca
authors: Barbara G
authors: BG
authors: Vickrey
authors: Stefanie D
authors: SD
authors: Vassar
authors: Anne T
authors: AT
authors: Berg
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010287:Parent-Child Relations; D010290:Parents / Q000523:psychology; D019727:Proxy; D011594:Psychometrics; D011788:Quality of Life; D012189:Retrospective Studies; D012640:Seizures / Q000503:physiopathology* / Q000523:psychology*; D011795:Surveys and Questionnaires