title: [Cirrhotic cardiomyopathy: a specific entity].
abstract: Cirrhosis is a frequent and severe condition, which is the late stage of numerous chronic liver diseases. It is associated with major hemodynamic alterations characteristic of hyperdynamic circulation and with a series of structural, functional, electrophysiological and biological heart abnormalities termed cirrhotic cardiomyopathy. The pathogenesis of this syndrome is multifactorial. It is usually clinically latent or mild, likely because the peripheral vasodilatation significantly reduces the left ventricle afterload. However, sudden changes of hemodynamic state (vascular filling, surgical or transjugular intrahepatic porto-systemic shunts, peritoneo-venous shunts and orthotopic liver transplantation) or myocardial contractility (introduction of beta-blocker therapy) can unmask its presence, and sometimes convert latent to overt heart failure. Cirrhotic cardiomyopathy may also contribute to the pathogenesis of hepatorenal syndrome. This entity has been described recently, and its diagnostic criteria are still under debate. To date, current management recommendations are empirical, nonspecific measures. Recognition of cirrhotic cardiomyopathy depends on a high level of awareness for the presence of this syndrome, particularly in patients with advanced cirrhosis who undergo significant surgical, pharmacological or physiological stresses.
authors: Service de cardiologie et pathologie vasculaire, hôpital d'instruction des armées Legouest, Metz, France. abrondex@hotmail.com
authors: A
authors: A
authors: Brondex
authors: F
authors: F
authors: Arlès
authors: A-S
authors: AS
authors: Lipovac
authors: M
authors: M
authors: Richecoeur
authors: J-A
authors: JA
authors: Bronstein
mesh_terms: D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology*; D004562:Electrocardiography; D006439:Hemodynamics; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000209:etiology; D008103:Liver Cirrhosis / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation; D014655:Vascular Resistance