title: [Estimation of antihypertension efficiency and use of fixed combination perindopril+amlodipin by uncontrollable hypertension patients within the limits of routine  treatment].
abstract: The results of observational investigation by prescription of the fixed combination perindopril + amlodipin produced by to the uncontrollable hypertension patients by the previous therapy are described in the given article. In Kazan population 50 patients at the age of 32 to 92 with essential hypertension having blood pressure level of 140/90 mm/hg. Were included into the investigation. Before these patients took different groups of antihypertension preparation (including perindopril). The preparation was prescribed in different fixed dosage depending on duration of hypertension, quantity of taken hypertension groups of preparations and blood pressure level. Then during 1, 2, 3 months of treatment the physician had the possibility to determine the dosage necessary to prescribe. The prescription of perindopril in combination with amlodipin during 3 months led to certain lowering of systolic and diastolic arterial pressure for 38.2 and 11.6 mm/hg accordingly and 80% of patients had the required pressure level of (<140/90 mm/hg). Moreover, the frequency of heart beat reduced and necessary increase of patient compliance for treatment took place. Taking the preparation only 31% of patients had unwilling effects but it didnt require the abolition of the antihypertension therapy till the end of observation. As a result, the investigation confirmed the high efficiency, good perception, improvement of patient compliance for treatment by prescribing the fixed combination perindopril + amlodipin.
authors: G P
authors: GP
authors: Ishmurzin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D001682:Biological Availability; D018660:Blood Pressure Monitoring, Ambulatory; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D016903:Drug Monitoring / Q000379:methods*; D004351:Drug Resistance; D004357:Drug Synergism; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D017311:Amlodipine; D020913:Perindopril