title: Association of clusterin gene polymorphisms with late-onset Alzheimer's disease.
abstract: OBJECTIVE
  Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects.
  
  
  METHODS
  LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion.
  
  
  RESULTS
  Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk.
  
  
  CONCLUSIONS
  The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.
authors: Department of Neurology, Indiana University School of Medicine, Indianapolis, USA.
authors: Huiying
authors: H
authors: Gu
authors: Xing
authors: X
authors: Wei
authors: Shirley
authors: S
authors: Chen
authors: Alexander
authors: A
authors: Kurz
authors: Ulrich
authors: U
authors: Müller
authors: Thomas
authors: T
authors: Gasser
authors: Richard C
authors: RC
authors: Dodel
authors: Martin R
authors: MR
authors: Farlow
authors: Yansheng
authors: Y
authors: Du
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D051152:Clusterin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012737:Sex Factors
chemical_list: D051152:Clusterin