title: Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis.
abstract: We compared the rate and extent of anidulafungin's and fluconazole's activity in neutropenic and non-neutropenic mice with Candida albicans invasive candidiasis. In immunocompetent mice, anidulafungin significantly improved survival vs. controls and fluconazole, and significant reductions in (1→3)-β-D-glucan and fungal burden were observed. In neutropenic animals, the highest doses of anidulafungin (5 mg/kg) and fluconazole (10 mg/kg) also improved survival and reduced fungal burden. However, there were no differences in survival between these antifungals as anidulafungin's activity was attenuated in this model. These results demonstrate that the extent of anidulafungin in vivo efficacy may be dependent on host immune status.
authors: University of Texas at Austin College of Pharmacy, Austin, TX 78229, USA. wiederholdn@uthscsa.edu
authors: N P
authors: NP
authors: Wiederhold
authors: L K
authors: LK
authors: Najvar
authors: R
authors: R
authors: Bocanegra
authors: W R
authors: WR
authors: Kirkpatrick
authors: T F
authors: TF
authors: Patterson
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D001769:Blood / Q000382:microbiology; D001774:Blood Chemical Analysis; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D054714:Echinocandins / Q000008:administration & dosage*; D015725:Fluconazole / Q000008:administration & dosage*; D051379:Mice; D008813:Mice, Inbred ICR; D009503:Neutropenia / Q000150:complications; D011509:Proteoglycans; D016019:Survival Analysis; D016896:Treatment Outcome; D047071:beta-Glucans / Q000097:blood
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K; D015725:Fluconazole; D000077612:Anidulafungin