title: Protective role of quercetin on PCBs-induced oxidative stress and apoptosis in hippocampus of adult rats.
abstract: Polychlorinated biphenyls (PCBs) exposure produces neurodegeneration and induces oxidative stress. Neuroprotective role of quercetin, on PCBs induced apoptosis in hippocampus has not yet been studied. The present study is focused to see whether quercetin supplementation precludes against PCBs induced oxidative stress and hippocampal apoptosis. The results have shown that quercetin at 50 mg/kg bwt/30 days has protected oxidative stress in hippocampus of adult male rats. Quercetin, a free radical scavenger decreased the levels of oxidative stress markers in the hippocampus of simultaneous PCB+quercetin treated rats. The pro-apoptotic and anti-apoptotic molecules such as Bad, Bid, Bax and Bcl2 were altered in the hippocampus of experimental animals. PCBs increased the DNA damage and induced neurodegeneration were assessed by histological studies. PCB induced ROS may be linked to increased hippocampal neuronal apoptosis. Quercetin supplementation decreased the neuronal damage and scavenged the free radicals induced by PCBs and protects PCBs induced apoptosis and oxidative stress.
authors: Department of Endocrinology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India.
authors: Kandaswamy
authors: K
authors: Selvakumar
authors: Senthamilselvan
authors: S
authors: Bavithra
authors: Muralidharan
authors: M
authors: Suganthi
authors: Chellakan Selvanesan
authors: CS
authors: Benson
authors: Perumal
authors: P
authors: Elumalai
authors: Ramachandran
authors: R
authors: Arunkumar
authors: Gunasekaran
authors: G
authors: Krishnamoorthy
authors: Prabhu
authors: P
authors: Venkataraman
authors: Jagadeesan
authors: J
authors: Arunakaran
mesh_terms: D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D011794:Quercetin; D011078:Polychlorinated Biphenyls