title: Cell cycle regulation in hematopoietic stem cells.
abstract: Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must persist for a lifetime, the balance between their proliferation and quiescence is carefully regulated to ensure blood homeostasis while limiting cellular damage. Cell cycle regulation therefore plays a critical role in controlling HSC function during both fetal life and in the adult. The cell cycle activity of HSCs is carefully modulated by a complex interplay between cell-intrinsic mechanisms and cell-extrinsic factors produced by the microenvironment. This fine-tuned regulatory network may become altered with age, leading to aberrant HSC cell cycle regulation, degraded HSC function, and hematological malignancy.
authors: Department of Medicine, Division of Hematology/Oncology, The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Eric M
authors: EM
authors: Pietras
authors: Matthew R
authors: MR
authors: Warr
authors: Emmanuelle
authors: E
authors: Passegué
mesh_terms: D000375:Aging; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D049109:Cell Proliferation; D004622:Embryo, Mammalian / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D018797:Cell Cycle Proteins