title: [Comparative study of the efficacy and safety of two anti-emetic protocols in gynecological chemotherapy].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of an update to an anti-emetic protocol in chemotherapy for gynecological tumours.
  
  
  METHODS
  Prospective observational study performed over 12 months in a general hospital with 400 beds. We evaluated the efficacy of the old anti-emetic protocol, a new protocol was implemented, and its efficacy was determined. We included patients with gynaecological tumours that sought treatment at the Day Hospital. After each chemotherapy cycle, patients filled out a survey that registered the number and severity of episodes of nausea/vomiting and other adverse effects. The efficacy of treatment was measured as complete response (no nausea or vomit) in the acute phase (first 24h after chemotherapy) and late phase (2-5 days after chemotherapy). We also evaluated whether age, the type of protocol, and the emetogenous power of the different treatment schemes could influence patient response.
  
  
  RESULTS
  We analysed 102 chemotherapy cycles under the old protocol (52 patients) and 293 cycles under the new protocol (98 patients). We observed significant differences in complete response rates in the late phase between old and new protocols (36.27% vs 67.38%, P<.0001). The probability of obtaining a complete response using the new protocol was twice as high as with the old protocol in acute emesis (OR=1.85, 95% CI: 1.05-3.24, P=.03) and four times higher in late emesis (OR=4.27, 95% CI: 2.59-7.02, P<.0001).
  
  
  CONCLUSIONS
  A greater percentage of complete responses to late emesis was obtained using the new protocol. Age and the low emetogenous power of the treatment schemes were predictive factors for complete response in acute emesis.
authors: Servicio de Farmacia, Hospital de Galdakao-Usansolo, Bizkaia, España. anamaria.dejuanarroyo@osakidetza.net
authors: A
authors: A
authors: de Juan Arroyo
authors: A
authors: A
authors: Urrutia Losada
authors: A
authors: A
authors: López de Torre Querejazu
authors: A
authors: A
authors: Santos Ibáñez
authors: E
authors: E
authors: Ibarra García
authors: I
authors: I
authors: Palacios Zabalza
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000932:Antiemetics