title: Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.
abstract: Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.
authors: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, United States.
authors: Rachel D
authors: RD
authors: Slack
authors: Bryan T
authors: BT
authors: Mott
authors: Lauren E
authors: LE
authors: Woodard
authors: Abhai
authors: A
authors: Tripathi
authors: Abhai
authors: A
authors: Triphati
authors: David
authors: D
authors: Sullivan
authors: Elizabeth
authors: E
authors: Nenortas
authors: Sonya C T
authors: SC
authors: Girdwood
authors: Theresa A
authors: TA
authors: Shapiro
authors: Gary H
authors: GH
authors: Posner
mesh_terms: D000284:Administration, Oral; D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D008288:Malaria / Q000188:drug therapy*; D015767:Mefloquine / Q000627:therapeutic use*; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D010962:Plasmodium berghei; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D013454:Sulfoxides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000813:Anilides; D000962:Antimalarials; D013440:Sulfides; D013450:Sulfones; D013454:Sulfoxides; D015767:Mefloquine