title: The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice.
abstract: The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20 mg/kg, i.p.) attenuated operant responding for morphine (0.1 mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction.
authors: Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria 3010, Australia.
authors: Robyn M
authors: RM
authors: Brown
authors: Monique R
authors: MR
authors: Stagnitti
authors: Jhodie R
authors: JR
authors: Duncan
authors: Andrew J
authors: AJ
authors: Lawrence
mesh_terms: D000701:Analgesics, Opioid; D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant; D003463:Cues; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000517:prevention & control* / Q000523:psychology*; D010880:Piperidines / Q000494:pharmacology*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D012054:Reinforcement, Psychology; D012646:Self Administration; D015819:Substance Abuse, Intravenous / Q000523:psychology; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: C541428:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)piperidine; D000701:Analgesics, Opioid; C578936:Grm5 protein, mouse; D009294:Narcotics; D010880:Piperidines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D013844:Thiazoles; D009020:Morphine