title: Influence of triiodothyronine on the contractile effect of D-nor-pseudoephedrine.
abstract: Here we contrast the vascular smooth muscle contractility produced by D-nor-pseudoephedrine, alone or combined with triiodothyronine, on the aorta and coronary vasculature of the rat. At high concentrations (greater than those found in normal therapeutic dosing) D-nor-pseudoephedrine contracted the aorta. In contrast, it produced vasodilation on pre-contracted aorta independently of the vasoconstrictor employed or the presence of vascular endothelium. D-nor-pseudoephedrine increased coronary perfusion pressure, but the effect was smaller than the vasoconstriction produced by phenylephrine (a full alpha 1 adrenergic agonist), and was blocked by the pre-treatment with triiodothyronine. These results suggest cardiovascular risks in the use of D-nor-pseudoephedrine for weight loss.
authors: Instituto Nacional de Perinatología, I.P.N., México. drcarloscastillo@hotmail.com
authors: Carlos
authors: C
authors: Castillo-Henkel
authors: Jorge
authors: J
authors: López-Canales
authors: María del Carmen
authors: Mdel C
authors: Castillo-Hernández
authors: Juan
authors: J
authors: Asbun-Bojalil
authors: Raul
authors: R
authors: Morín-Zaragoza
authors: Daniel
authors: D
authors: Rodríguez-Choreño
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D010665:Phenylpropanolamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D014284:Triiodothyronine; D010656:Phenylephrine; C005331:norpseudoephedrine; D010665:Phenylpropanolamine