title: Hepatoregenerative role of bone morphogenetic protein-9.
abstract: Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in hepatocytes; therefore it is proposed to be a candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due to the portocaval shunt, insulin bypasses the organ and the liver undergoes atrophy. Parenteral administration of insulin reverses atrophy by stimulating mitogenic activity of the hepatocytes. Because BMP-9 has a signaling pathway similar to other BMPs and insulin, it is to be expected that BMP-9 has a certain regenerative role in the liver, supporting the above-mentioned is evidence of BMP-9 expression in Dissè's spaces and BMP-7's mitogenic activity in mucosal cells. However, further studies are needed to confirm the possible regenerative role of BMP-9.
authors: Department of Forensic Medicine and Criminalistics, Rijeka University School of Medicine, Rijeka, Croatia.
authors: Ivan
authors: I
authors: Sosa
authors: Olga
authors: O
authors: Cvijanovic
authors: Tanja
authors: T
authors: Celic
authors: Drazen
authors: D
authors: Cuculic
authors: Zeljka
authors: Z
authors: Crncevic-Orlic
authors: Lucian
authors: L
authors: Vukelic
authors: Sanja
authors: S
authors: Zoricic Cvek
authors: Luka
authors: L
authors: Dudaric
authors: Alan
authors: A
authors: Bosnar
authors: Dragica
authors: D
authors: Bobinac
mesh_terms: D000818:Animals; D055427:Growth Differentiation Factor 2 / Q000378:metabolism*; D006801:Humans; D008115:Liver Regeneration / Q000502:physiology*; D051379:Mice; D008954:Models, Biological
chemical_list: D055427:Growth Differentiation Factor 2