title: Efficacy of desensitizing dentifrices to occlude dentinal tubules.
abstract: Dentine hypersensitivity occurs when patent dentinal tubules are subjected to external stimuli, with pain being reduced by products that occlude tubules. This study compared the efficacy of a recently developed arginine-containing dentifrice, two established strontium-based products, and a fluoride control to occlude tubules when subjected to acid challenge. Dentine specimens with patent tubules were divided into four groups that were treated with a slurry consisting of one of the pastes mixed with stimulated human saliva. Treated specimens were further subdivided and soaked in 0.3% citric acid for 10 s, 30 s, 2 min, 5 min or 10 min. Tubule occlusion on representative scanning electron microscopy images was scored by blind review. All three desensitizing pastes offered good tubule occlusion, which was maintained to varying degrees following acidic challenge. After immersion in acid for 10 and 30 s, the strontium acetate- and arginine-containing pastes almost fully occluded tubules, but only the strontium acetate paste retained this level of occlusion after immersion in acid for 2 min, with strong statistical evidence that this paste occluded more tubules than the other pastes after immersion in acid for 2 or 5 min. This suggests that strontium acetate pastes may be the most effective at reducing dentine hypersensitivity.
authors: Clinical Trials Group, School of Oral and Dental Science, University of Bristol, Bristol             School of Oral and Dental Science, University of Bristol, Bristol, UK.
authors: Maria
authors: M
authors: Davies
authors: Elizabeth M
authors: EM
authors: Paice
authors: Sian B
authors: SB
authors: Jones
authors: Sam
authors: S
authors: Leary
authors: Andrew R
authors: AR
authors: Curtis
authors: Nicola X
authors: NX
authors: West
mesh_terms: D001120:Arginine / Q000008:administration & dosage* / Q000737:chemistry; D045424:Complex Mixtures / Q000737:chemistry / Q000627:therapeutic use; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D003807:Dentin Sensitivity / Q000628:therapy*; D004338:Drug Combinations; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008964:Molar, Third; D009566:Nitrates / Q000737:chemistry / Q000627:therapeutic use; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use; D017680:Potassium Compounds / Q000737:chemistry / Q000627:therapeutic use; D012824:Silicic Acid / Q000737:chemistry / Q000627:therapeutic use; D013324:Strontium / Q000008:administration & dosage* / Q000737:chemistry; D014092:Tooth Root / Q000187:drug effects / Q000648:ultrastructure; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D045424:Complex Mixtures; D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D004338:Drug Combinations; D005460:Fluorides, Topical; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; D014100:Toothpastes; C444700:colgate sensitive; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D001120:Arginine; D005459:Fluorides; D013324:Strontium