title: Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells.
abstract: Cadmium is a typical environmental pollutant and the causative agent of itai-itai disease. Ubiquitin ligases potentially involved in mediating the effects of cadmium toxicity were investigated by RNA interference using a panel of small inhibitory (si)RNAs. The results demonstrated that the inhibition of gene expression of FBXO6 sensitizes HEK293 cells to cadmium.
authors: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohoku University, Sendai, Miyagi, Japan.
authors: Gi-Wook
authors: GW
authors: Hwang
authors: Ke
authors: K
authors: Du
authors: Tsutomu
authors: T
authors: Takahashi
authors: Akira
authors: A
authors: Naganuma
mesh_terms: D002104:Cadmium / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D015870:Gene Expression / Q000187:drug effects*; D057809:HEK293 Cells; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics*; D014162:Transfection
chemical_list: D004785:Environmental Pollutants; D034741:RNA, Small Interfering; D002104:Cadmium; C479752:FBXO6 protein, human; D044843:SKP Cullin F-Box Protein Ligases