title: Brain natriuretic peptide in the evaluation of emergency department dyspnea: is there a role?
abstract: BACKGROUND
  Acute decompensated congestive heart failure (ADCHF) is a common etiology of dyspnea in emergency department (ED) patients. Delayed diagnosis of ADCHF increases morbidity and mortality. Two cardiac biomarkers, N-terminal-pro brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) have demonstrated excellent sensitivity in diagnostic accuracy studies, but the clinical impact on patient-oriented outcomes of these tests remains in question.
  
  
  OBJECTIVE
  Does emergency physician awareness of BNP or NT-proBNP level improve ADCHF patient-important outcomes including ED length of stay, hospital length of stay, cardiovascular mortality, or overall health care costs?
  
  
  METHODS
  Five trials have randomized clinicians to either knowledge of or no knowledge of ADCHF biomarker levels in ED patients with dyspnea and some suspicion for heart failure. In assessing patient-oriented outcomes such as length-of-stay, return visits, and overall health care costs, the randomized controlled trials fail to provide evidence of unequivocal benefit to patients, clinicians, or society.
  
  
  CONCLUSIONS
  Clinician awareness of BNP or NT-proBNP levels in ED dyspnea patients does not necessarily improve outcomes. Future ADCHF biomarker trials must assess patient-oriented outcomes in conjunction with validated risk-stratification instruments.
authors: Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
authors: Christopher R
authors: CR
authors: Carpenter
authors: Samuel M
authors: SM
authors: Keim
authors: Andrew
authors: A
authors: Worster
authors: Peter
authors: P
authors: Rosen
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004417:Dyspnea / Q000175:diagnosis*; D004635:Emergency Medicine; D004636:Emergency Service, Hospital / Q000191:economics / Q000706:statistics & numerical data; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality; D017721:Hospital Costs; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010351:Patient Discharge / Q000706:statistics & numerical data; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain