title: Maturation profiles of peripheral blood dendritic cells in patients with endogenous uveitis.
abstract: To determine whether or not maturation of dendritic cells (DCs) is associated with pathogenesis of endogenous uveitis, we analyzed expression of maturation markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in peripheral blood (PB) DCs for comparison between healthy controls (HCs) and uveitis patients. A total of 21 patients and 16 HCs were included. Flow cytometric analysis was performed using PB DCs during the active phase of intraocular inflammation. CD86 and HLA-DR expression was higher in PB DCs from uveitis patients versus HCs, whereas that of CD80 was not significantly different. Levels of CD86 and HLA-DR expression tended to parallel those of inflammatory activity, and decreased after anti-inflammatory therapy. However, expression of CD86 and HLA-DR, even in remission, was not completely down-regulated to the low levels found in HCs. Our results indicate the maturation of DCs may play a role in the pathogenesis of endogenous uveitis. The relatively high expression of HLA-DR and co-stimulatory molecules even in the quiescence of inflammation suggests maturation of DCs may be associated with chronicity and recurrence of uveitis.
authors: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Tae Wan
authors: TW
authors: Kim
authors: Jae Seung
authors: JS
authors: Kang
authors: Joo Myoung
authors: JM
authors: Kong
authors: Seyeon
authors: S
authors: Bae
authors: Yeonsil
authors: Y
authors: Yu
authors: Hum
authors: H
authors: Chung
authors: Hyeong Gon
authors: HG
authors: Yu
mesh_terms: D000328:Adult; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen / Q000378:metabolism; D016022:Case-Control Studies; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014605:Uveitis / Q000276:immunology* / Q000503:physiopathology
chemical_list: D018122:B7-1 Antigen; D051940:B7-2 Antigen; D006684:HLA-DR Antigens