title: [Measurement of bird specific antibody in bird-related hypersensitivity pneumonitis].
abstract: Since the avian antigen is one of the important causative antigens in hypersensitivity pneumonitis, measurement of bird-specific antibody should be readily available. We measured IgG and IgA antibodies against pigeons and budgerigars by the ImmunoCap system in bird-related hypersensitivity pneumonitis (BRHP) to evaluate their diagnostic utility. In acute BRHP, antibodies markedly increased and showed high sensitivity and specificity ranging from 75-100% based on the cut-off values determined by ROC analysis. In chronic BRHP, antibody reactivity slightly increased, showing a sensitivity of 27-73% and specificity of 45-100%. Pigeon antibodies evaluated by the ImmunoCap system showed a good correlation with anti-pigeon dropping extract antibodies measured by ELISA. In conclusion, measurement of antibodies against pigeons and budgerigars are helpful for the diagnosis of BRHP.
authors: Department of Integrated Pulmonology, Tokyo Medical and Dental University.
authors: Naohiko
authors: N
authors: Inase
authors: Koji
authors: K
authors: Unoura
authors: Yasunari
authors: Y
authors: Miyazaki
authors: Makito
authors: M
authors: Yasui
authors: Yasuyuki
authors: Y
authors: Yoshizawa
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood*; D001716:Bird Fancier's Lung / Q000175:diagnosis / Q000276:immunology*; D001717:Birds / Q000276:immunology*; D010856:Columbidae / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D046408:Melopsittacus / Q000276:immunology; D012680:Sensitivity and Specificity
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G