title: Manipulation of kinase signaling by bacterial pathogens.
abstract: Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection. These effectors divert host cell signaling pathways to the benefit of the pathogen and frequently target kinase signaling cascades. Notable pathways that are usurped include the nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated kinase (PAK) pathways. Analyzing the functions of pathogenic effectors and their intersection with host kinase pathways has provided interesting insights into both the mechanisms of virulence and eukaryotic signaling.
authors: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Anne Marie
authors: AM
authors: Krachler
authors: Andrew R
authors: AR
authors: Woolery
authors: Kim
authors: K
authors: Orth
mesh_terms: D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases