title: Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei.
abstract: We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.
authors: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors: Peng-Yu
authors: PY
authors: Yang
authors: Min
authors: M
authors: Wang
authors: Cynthia Y
authors: CY
authors: He
authors: Shao Q
authors: SQ
authors: Yao
mesh_terms: D000977:Antiparasitic Agents / Q000494:pharmacology*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D020869:Gene Expression Profiling; D010649:Phenylalanine / Q000031:analogs & derivatives; D010879:Piperazines; D040901:Proteomics; D015800:Protozoan Proteins / Q000378:metabolism*; D014105:Tosyl Compounds; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000378:metabolism; D014753:Vinyl Compounds / Q000494:pharmacology*
chemical_list: D000977:Antiparasitic Agents; D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; D010879:Piperazines; D015800:Protozoan Proteins; D014105:Tosyl Compounds; D014753:Vinyl Compounds; C487484:N-pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl; D010649:Phenylalanine