title: Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing.
abstract: We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.
authors: Organ and Tissue Transplantation Immunology, Regenerative Medicine Department, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
authors: Sara
authors: S
authors: Frison
authors: Elena
authors: E
authors: Longhi
authors: Martina
authors: M
authors: Mantovani
authors: Monica
authors: M
authors: Mantia
authors: Cinzia
authors: C
authors: Tagliaferri
authors: Daniela
authors: D
authors: Di Giorgio
authors: Mario
authors: M
authors: Scalamogna
authors: Francesca
authors: F
authors: Poli
mesh_terms: D000483:Alleles; D001483:Base Sequence; D060005:Genotyping Techniques / Q000379:methods*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D044465:White People / Q000235:genetics
chemical_list: D059811:HLA-DRB1 Chains