title: Highly regioselective hydroaminomethylation of terminal olefins to linear amines using Rh complexes with a Tetrabi phosphorus ligand.
abstract: A highly regioselective hydroaminomethylation of terminal olefins catalyzed by Rh complexes with 2, 2', 6, 6'-tetrakis ((diphenylphosphino)methyl)-1, 1'-biphenyl (Tetrabi) ligand has been developed. Up to 99 % amine selectivity, 168 linear/branched amine product ratio (n/i), and 97.4 % linear amine yield has been obtained at a substrate/rhodium precursor ratio (S/Rh) of 1000 with this methodology. The turnover number was achieved 6930 at 10,000 S/Rh ratio, and the n/i can reach up to >525. Several different olefins and secondary amines have been applied successfully with high chemoselectivity (99 %), yield (>98 %), and regioselectivity (>120).
authors: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, PR China.
authors: Guodu
authors: G
authors: Liu
authors: Kexuan
authors: K
authors: Huang
authors: Chaoxian
authors: C
authors: Cai
authors: Bonan
authors: B
authors: Cao
authors: Mingxin
authors: M
authors: Chang
authors: Wenjun
authors: W
authors: Wu
authors: Xumu
authors: X
authors: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000588:Amines; D001713:Biphenyl Compounds; D008024:Ligands; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D012238:Rhodium