title: Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function.
abstract: The pregnancy hormone human chorionic gonadotropin (hCG) is essential to sustain early pregnancy and involved in regulation of progesterone production, decidualization, and cytotrophoblast differentiation. It binds to and activates the G-protein coupled luteinizing hormone/hCG-receptor, activating the cAMP/protein kinase A (PKA) pathway which results in the phosphorylation of specific intracellular target proteins. Specificity in cAMP signaling is ensured by generation of localized pools of cAMP controlled by phosphodiesterases and by discrete spatial and temporal activation of PKA in supramolecular signaling clusters inside the cell organized by A-kinase-anchoring proteins. Here we discuss spatiotemporal regulation of PKA signaling in response to hCG controlling placental function.
authors: The Biotechnology Centre of Oslo, Blindern, Oslo, Norway.
authors: M S
authors: MS
authors: Weedon-Fekjær
authors: K
authors: K
authors: Taskén
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005260:Female; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010929:Placentation; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011974:Receptors, LH / Q000378:metabolism*; D015398:Signal Transduction; D014327:Trophoblasts / Q000201:enzymology / Q000378:metabolism*; D058067:Wavelet Analysis
chemical_list: D054758:A Kinase Anchor Proteins; D006063:Chorionic Gonadotropin; D011257:Pregnancy Proteins; D020033:Protein Isoforms; D011974:Receptors, LH; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases