title: Class 3 semaphorins and their receptors in physiological and pathological angiogenesis.
abstract: Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axon guidance factors mediating their signal transduction by forming complexes with neuropilins and plexins. However, the wide expression pattern of Sema3 suggested additional functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis.
authors: Microcirculation Research Group, Academic Unit of Surgical Oncology, Faculty of Medicine, Dentistry and Health University of Sheffield, Sheffield S10 2RX, UK. c.a.staton@shef.ac.uk
authors: Carolyn A
authors: CA
authors: Staton
mesh_terms: D000818:Animals; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D011956:Receptors, Cell Surface / Q000378:metabolism*; D039961:Semaphorins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D039961:Semaphorins