title: Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films.
abstract: We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas.
authors: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong.
authors: C K M
authors: CK
authors: Ng
authors: E Y W
authors: EY
authors: Chong
authors: V A L
authors: VA
authors: Roy
authors: K M C
authors: KM
authors: Cheung
authors: K W K
authors: KW
authors: Yeung
authors: K N
authors: KN
authors: Yu