title: Effect of angiotensin II on the left ventricular function in a near-term fetal sheep with metabolic acidemia.
abstract: We tested the hypothesis that, in acute metabolic acidemia, the fetal left ventricle (LV) has the capacity to increase its contractility in response to angiotensin II infusion. Eleven ewes and their fetuses were instrumented at 127-138/145 days of gestation. The effect of angiotensin II on fetal LV function was assessed using intraventricular pressure catheter and tissue Doppler imaging (TDI). Angiotensin II increased fetal arterial blood pressure, whereas pH and pO(2) decreased. The heart rate and systemic venous pressure were not affected significantly. The LV end-diastolic and end-systolic pressures, as well as dP/dt(max), increased. The TDI-derived LV longitudinal myocardial isovolumic contraction velocity and its acceleration and velocity during early filling were higher than those at baseline. The incidence of absent isovolumic relaxation velocity was greater during angiotensin II infusion. In summary, during acute metabolic acidemia, the fetal left ventricle could increase its contractility in response to inotropic stimulus even in the presence of increased afterload. The diastolic LV function parameters were altered by angiotensin II.
authors: Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø and Department of Obstetrics and Gynecology, University Hospital of Northern Norway, 9038 Tromsø, Norway. ganesh.acharya@uit.no
authors: Ganesh
authors: G
authors: Acharya
authors: James C
authors: JC
authors: Huhta
authors: Mervi
authors: M
authors: Haapsamo
authors: Ole-Jakob
authors: OJ
authors: How
authors: Tiina
authors: T
authors: Erkinaro
authors: Juha
authors: J
authors: Räsänen
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000196:embryology / Q000503:physiopathology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D015150:Echocardiography, Doppler; D005260:Female; D005333:Fetus; D006340:Heart Rate, Fetal / Q000187:drug effects; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000196:embryology; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D011247:Pregnancy; D012756:Sheep; D013599:Systole / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D016276:Ventricular Function / Q000187:drug effects*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II