title: Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis.
abstract: OBJECTIVE
  To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients.
  
  
  METHODS
  From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations.
  
  
  RESULTS
  When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63).
  
  
  CONCLUSIONS
  GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.
authors: Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan.
authors: Yu-Wei
authors: YW
authors: Chen
authors: Han-Hsiang
authors: HH
authors: Chen
authors: Tsang-En
authors: TE
authors: Wang
authors: Ching-Wei
authors: CW
authors: Chang
authors: Chen-Wang
authors: CW
authors: Chang
authors: Chih-Jen
authors: CJ
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005355:Fibrosis / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D017052:Hospital Mortality; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D003404:Creatinine