title: Pregnancy rates with recombinant versus urinary human chorionic gonadotropin in in vitro fertilization: an observational study.
abstract: Randomized clinical trials (RCTs) demonstrated the equal efficacy of urinary human chorionic gonadotropin (uhCG) and recombinant hCG (rhCG) products in in vitro fertilisation (IVF). However, limitations inherent with RCTs necessitate the reinforcement of RCT results in real-life. We retrospectively analyzed pregnancies after treatment with rhCG and uhCG products (n = 391, and 96, resp.). We found that laboratory-verified pregnancy occurred more frequently in rhCG patients than in those on uhCG (43% versus 30%, P = 0.02). The association remains significant (P = 0.002) after its adjustment for clinical characteristics. The prevalence of laboratory-verified pregnancies was higher with GnRH agonist use (P = 0.012) and BMI under 30 kg/m(2) (P = 0.053) while decreased the age (P = 0.014) and the number of previous failed attempts (P = 0.08). Similar (but not significant) trends were observed with rates of pregnancy filled the 24th week. These results reinforce RCTs supporting the notion that rhCG is more efficient as uhCG during IVF.
authors: Infertility Center of Buda, Szt János Hospital, H-1125 Budapest, Hungary.
authors: József
authors: J
authors: Zeke
authors: Katalin
authors: K
authors: Kanyó
authors: Helga
authors: H
authors: Zeke
authors: Aron
authors: A
authors: Cseh
authors: Barna
authors: B
authors: Vásárhelyi
authors: András
authors: A
authors: Szilágyi
authors: János
authors: J
authors: Konc
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins