title: Steroidal alkaloids from the bulbs of Fritillaria unibracteata.
abstract: Two new steroidal alkaloids peimisine-3-O-β-D-glucopyranoside (1) and puqiedinone-3-O-β-D-glucopyranoside (3), together with three known compounds peimisine (2), puqiedinone (4), and puqiedine (5), were isolated and characterized from the bulbs of Fritillaria unibracteata. Their structures were fully elucidated by spectroscopic and chemical methods. Compound 1 showed moderate protection effect on neurotoxicity of PC12 cell lines induced by rotenone.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Qing-Jian
authors: QJ
authors: Zhang
authors: Zhong-Fei
authors: ZF
authors: Zheng
authors: De-Quan
authors: DQ
authors: Yu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002595:Cevanes / Q000737:chemistry / Q000494:pharmacology; D031410:Fritillaria / Q000737:chemistry*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D002595:Cevanes; D018696:Neuroprotective Agents; D013256:Steroids; C052510:peimisine; C069537:sinpeinine A