title: High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer.
abstract: Recent studies indicate that ER/PR/HER-2-negative (triple-negative, TN) breast cancers may be "CTA-rich" tumors, suggesting the possibility of CTA-based cancer vaccines as a treatment option for patients bearing these tumors. MAGE-A10 together with NY-ESO-1 is probably the most immunogenic CTA, representing a potentially highly attractive target of active specific immunotherapies. Paraffin-embedded tumor sections were collected retrospectively from 165 breast cancer patients diagnosed between 2002 and 2003. Immunohistochemical staining for MAGE-A10 and NY-ESO-1 was performed. The expression of MAGE-A10 and NY-ESO-1 was correlated with other clinicopathological variables. MAGE-A10 expression (score ≥ 2+) was detected in 105/164 (64%), and NY-ESO-1 expression (score ≥ 2+) was observed in 14/164 (8.5%) patients. No correlation between MAGE-A10 and NY-ESO-1 expression and tumor size, tumor grade, Ki-67 and lymph nodes status was detectable. MAGE-A10 expression was significantly associated with ER-negative (P = 0.002), PR-negative (P = 0.002) and HER-2-negative (P = 0.044) tumors. We clearly showed that MAGE-A10 is frequently expressed in the group of TN patients, where the majority (85.7%) of tumors express this CTA. Because of limited therapeutic options for the triple-negative breast cancer, the frequent expression of MAGE-A10 CTA in these cancers may offer the opportunity for a much needed additional treatment for this group of patients.
authors: Oncology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, Croatia. tanja.badovinac@zg.t-com.hr
authors: Tanja
authors: T
authors: Badovinac Črnjević
authors: Badovinac Črnjević
authors: BČ
authors: Tanja
authors: Giulio
authors: G
authors: Spagnoli
authors: Spagnoli
authors: S
authors: Giulio
authors: Antonio
authors: A
authors: Juretić
authors: Juretić
authors: J
authors: Antonio
authors: Jasminka
authors: J
authors: Jakić-Razumović
authors: Jakić-Razumović
authors: JR
authors: Jasminka
authors: Paula
authors: P
authors: Podolski
authors: Podolski
authors: P
authors: Paula
authors: Nera
authors: N
authors: Šarić
authors: Šarić
authors: Š
authors: Nera
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis*; D012189:Retrospective Studies; D046888:Tissue Array Analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C104948:CTAG1B protein, human; C119317:MAGE-A10 antigen; D008565:Membrane Proteins; D009363:Neoplasm Proteins