title: The importance of tumor proliferation markers in assessing lesions of the palatine tonsil.
abstract: Oropharyngeal cancer, and especially squamous cell carcinoma, is one of the most common cancers worldwide, and its incidence is increasing, with the palatine tonsil being one of the main locations. The etiopathogenic factors, together with its location as well as the available immunohistochemical methods, make this type of cancer an accessible one in terms of diagnosis. However, it is usually diagnosed in late stages. Therefore, we tried to elucidate the causes of treatment failures and development of local recurrence. For this, we reassessed the proliferative pattern of tonsil lesions using the anti-p53, anti-PCNA and anti-Ki67 antibodies on 73 tonsil fragments collected after curative surgery on adults aged between 28 and 86 years. Following the reevaluation of the histopathological examination using markers for cell proliferation, the diagnosis was modified in 16 cases, representing about 22% of the cases take into study. By using immunohistochemical markers in the histopathological examination the diagnosis is improved, leading to a more appropriate therapeutical approach.
authors: Department of ENT, University of Medicine and Pharmacy of Craiova, Romania. carmen_mogo@yahoo.com
authors: Carmen Aurelia
authors: CA
authors: Mogoantă
authors: Daniela Adriana
authors: DA
authors: Ion
authors: G
authors: G
authors: Stanciu
authors: Elena
authors: E
authors: Ioniţă
authors: Adriana
authors: A
authors: Bold
authors: Garofiţa Olivia
authors: GO
authors: Mateescu
authors: O T
authors: OT
authors: Pop
authors: Irina
authors: I
authors: Gheorghişor
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D014066:Palatine Tonsil / Q000378:metabolism* / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D017154:Stromal Cells / Q000473:pathology; D014067:Tonsillar Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53