title: Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients.
abstract: BACKGROUND
  To investigate the relationship between serum levels of cystatin C and adiponectin in patients with type 2 diabetes.
  
  
  METHODS
  We examined serum cystatin C and adiponectin levels in 234 patients with type 2 diabetes who visited our hospital.
  
  
  RESULTS
  The serum level of cystatin C was positively correlated with age (P < 0.001), duration of diabetes (P = 0.013), serum creatinine (P < 0.001), uric acid (P < 0.001), and adiponectin (p = 0.001), while it was inversely correlated with estimated glomerular filtration rate (P < 0.001). Serum adiponectin was significantly higher in patients with high serum cystatin C levels than in those with normal cystatin C levels (8.3 ± 4.7 and 6.2 ± 3.2 μg/mL, respectively; P < 0.001). Adiponectin was also significantly higher in male patients with high cystatin C levels, but not in females. In multiple regression analysis, serum adiponectin was also independently and significantly correlated to age, diastolic blood pressure, high-density lipoprotein cholesterol, triglyceride and serum cystatin C.
  
  
  CONCLUSIONS
  Serum adiponectin level was correlated with serum cystatin C level on simple and multiple regression analyses in patients with type 2 diabetes. Although circulating adiponectin is increased in advanced kidney disease, it might be biologically inactive due to binding to cystatin C and thus not display an anti-arteriosclerotic effect.
authors: Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan.
authors: Yoshiya
authors: Y
authors: Hosokawa
authors: Yuya
authors: Y
authors: Yamada
authors: Yoshinari
authors: Y
authors: Obata
authors: Megu Yamaguchi
authors: MY
authors: Baden
authors: Kenji
authors: K
authors: Saisho
authors: Arisa
authors: A
authors: Ihara
authors: Koji
authors: K
authors: Yamamoto
authors: Kiyonori
authors: K
authors: Katsuragi
authors: Yuji
authors: Y
authors: Matsuzawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D055316:Cystatin C; D014527:Uric Acid; D003404:Creatinine