title: Neonatal outcomes of small for gestational age preterm infants in Canada.
abstract: To compare the effect of small for gestational age (SGA) on mortality, major morbidity and resource utilization among singleton very preterm infants (<33 weeks gestation) admitted to neonatal intensive care units (NICUs) across Canada. Infants admitted to participating NICUs from 2003 to 2008 were divided into SGA (defined as birth weight <10th percentile for gestational age and sex) and non-small gestational age (non-SGA) groups. The risk-adjusted effects of SGA on neonatal outcomes and resource utilization were examined using multivariable analyses. SGA infants (n = 1249 from a cohort of 11,909) had a higher odds of mortality (adjusted odds ratio [AOR] 2.46; 95% confidence interval [CI], 1.93-3.14), necrotizing enterocolitis (AOR 1.57; 95% CI, 1.22-2.03), bronchopulmonary dysplasia (AOR 1.78; 95% CI, 1.48-2.13), and severe retinopathy of prematurity (AOR 2.34; 95% CI, 1.71-3.19). These infants also had lower odds of survival free of major morbidity (AOR 0.50; 95% CI, 0.43-0.58) and respiratory distress syndrome (AOR 0.79; 95% CI, 0.68-0.93). In addition, SGA infants had a more prolonged stay in the NICU, and longer use of ventilation continuous positive airway pressure, and supplemental oxygen (p < 0.01 for all). SGA infants had a higher risk of mortality, major morbidities, and higher resource utilization compared with non-SGA infants.
authors: Department of Paediatrics, University of Toronto, Ontario, Canada. xqiu@mtsinai.on.ca
authors: Xiangming
authors: X
authors: Qiu
authors: Abhay
authors: A
authors: Lodha
authors: Prakesh S
authors: PS
authors: Shah
authors: K
authors: K
authors: Sankaran
authors: Mary M K
authors: MM
authors: Seshia
authors: Wendy
authors: W
authors: Yee
authors: Ann
authors: A
authors: Jefferies
authors: Shoo K
authors: SK
authors: Lee
mesh_terms: D001034:Apgar Score; D002170:Canada / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000401:mortality*; D007236:Infant, Small for Gestational Age; D007363:Intensive Care Units, Neonatal; D007902:Length of Stay / Q000706:statistics & numerical data*; D008171:Lung Diseases / Q000453:epidemiology; D008297:Male; D016017:Odds Ratio; D047928:Premature Birth / Q000401:mortality; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D018570:Risk Assessment