title: Coverage and yield of tuberculosis contact investigations in the Netherlands.
abstract: METHODS
  An increasing proportion of tuberculosis (TB) patients in low-incidence countries are immigrants. It is unclear whether contact investigations among immigrant patients are adequate.
  
  
  OBJECTIVE
  To determine whether ethnicity of pulmonary TB patients was associated with coverage and yield of contact investigations in the Netherlands.
  
  
  METHODS
  Contact investigation results were extracted from records of patients reported in the nationwide surveillance register in 2006 and 2007. Prevalence odds ratios (PORs) with 95% confidence intervals (CIs) were calculated to determine the association between patient ethnicity and coverage of contact investigations and the yield of individuals with Mycobacterium tuberculosis infection or TB.
  
  
  RESULTS
  Of the 1040 pulmonary TB patients reported, 642 (62%) were eligible for analysis. Compared to close contacts of Dutch patients, close contacts of immigrant patients were significantly less likely to be examined for TB (89% vs. 93%, POR 0.6, 95%CI 0.5-0.7) and infection (50% vs. 75%, POR 0.3, 95%CI 0.3-0.4), whereas the yield was significantly higher for disease (1.5% vs. 0.4%, POR 3.4, 95%CI 1.8-6.4) and infection (13% vs. 10%, POR 1.2, 95%CI 1.0-1.5).
  
  
  CONCLUSIONS
  The effectiveness of contact investigations in the Netherlands can be optimised by expanding the investigation of contacts of immigrant patients.
authors: KNCV Tuberculosis Foundation, The Hague, The Netherlands. mulderc@kncvtbc.nl
authors: C
authors: C
authors: Mulder
authors: H
authors: H
authors: van Deutekom
authors: E M
authors: EM
authors: Huisman
authors: W
authors: W
authors: Meijer-Veldman
authors: C G M
authors: CG
authors: Erkens
authors: J
authors: J
authors: van Rest
authors: M W
authors: MW
authors: Borgdorff
authors: F
authors: F
authors: van Leth
mesh_terms: D000328:Adult; D000368:Aged; D016358:Contact Tracing / Q000706:statistics & numerical data*; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data*; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012042:Registries; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult