title: Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses.
abstract: Herpes virus infections are chronic and co-exist with acquired immune responses that generally prevent severe damage to the host, while allowing periodic shedding of virus and maintenance of its transmission in the community. Herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) are typical in this regard and are representative of the viral subfamily Alphaherpesvirinae, which has a tropism for neuronal and epithelial cells. This review will emphasize recent progress in decoding the physiologically important CD8(+) and CD4(+) T cell responses to HSV in humans. The expanding data set is discussed in the context of the search for an effective HSV vaccine as therapy for existing infections and to prevent new infections.
authors: Department of Medicine, University of Washington, Seattle, WA, USA.
authors: K J
authors: KJ
authors: Laing
authors: L
authors: L
authors: Dong
authors: J
authors: J
authors: Sidney
authors: A
authors: A
authors: Sette
authors: D M
authors: DM
authors: Koelle
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology* / Q000517:prevention & control; D022283:Herpesvirus Vaccines; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018139:Simplexvirus / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
chemical_list: D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D022283:Herpesvirus Vaccines; D016056:Immunodominant Epitopes; D014764:Viral Proteins