title: Minimum alveolar concentration for blunting adrenergic responses (MAC-BAR) of sevoflurane in dogs.
abstract: It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.
authors: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. yamasita@rakuno.ac.jp
authors: Kazuto
authors: K
authors: Yamashita
authors: Erika
authors: E
authors: Furukawa
authors: Takaharu
authors: T
authors: Itami
authors: Tomohito
authors: T
authors: Ishizuka
authors: Jun
authors: J
authors: Tamura
authors: Kenjirou
authors: K
authors: Miyoshi
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008738:Methyl Ethers / Q000008:administration & dosage*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane