title: A concise asymmetric synthesis of (-)-rasfonin.
abstract: A very efficient total synthesis of the apoptosis inducer (-)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.
authors: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors: Yange
authors: Y
authors: Huang
authors: Adriaan J
authors: AJ
authors: Minnaard
authors: Ben L
authors: BL
authors: Feringa
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005231:Fatty Acids, Unsaturated; D011753:Pyrones; C416827:rasfonin