title: Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species.
abstract: Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays.
authors: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
authors: Abbas
authors: A
authors: Mollataghi
authors: Emilie
authors: E
authors: Coudiere
authors: A Hamid A
authors: AH
authors: Hadi
authors: Mat Ropi
authors: MR
authors: Mukhtar
authors: Khalijah
authors: K
authors: Awang
authors: Marc
authors: M
authors: Litaudon
authors: Athar
authors: A
authors: Ata
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D002176:Candida albicans / Q000187:drug effects; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D019770:Lauraceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000469:parasitology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C579548:2-hydroxy-9-methoxyaporphine; D000470:Alkaloids; D000935:Antifungal Agents; D001060:Aporphines; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; C081279:aporphine; D000110:Acetylcholinesterase