title: Toward automated oligosaccharide synthesis.
abstract: Carbohydrates have been shown to play important roles in biological processes. The pace of development in carbohydrate research is, however, relatively slow due to the problems associated with the complexity of carbohydrate structures and the lack of general synthetic methods and tools available for the study of this class of biomolecules. Recent advances in synthesis have demonstrated that many of these problems can be circumvented. In this Review, we describe the methods developed to tackle the problems of carbohydrate-mediated biological processes, with particular focus on the issue related to the development of the automated synthesis of oligosaccharides. Further applications of carbohydrate microarrays and vaccines to human diseases are also highlighted.
authors: The Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors: Che-Hsiung
authors: CH
authors: Hsu
authors: Shang-Cheng
authors: SC
authors: Hung
authors: Chung-Yi
authors: CY
authors: Wu
authors: Chi-Huey
authors: CH
authors: Wong
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D014612:Vaccines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D009844:Oligosaccharides; D014612:Vaccines