title: Molecular pathology and biomarkers of bladder cancer.
abstract: Bladder cancer originates in the epithelial lining of the bladder's mucosa and develops in association with several habitual, industrial, and environmental risk factors via papillary and non-papillary pathways. In this chapter we review novel concepts concerning the molecular mechanisms of early field change in bladder neoplasia stemming from whole-organ genomic mapping studies. These mechanisms are discussed in the context of molecular pathogenesis of bladder cancer and in relation to treatment and biomarker-based detection strategies.
authors: The University of Texas M.D. Anderson Cancer Center, Division of Pathology & Laboratory Medicine, Houston, TX, USA. bczernia@mdanderson.org
authors: Bogdan
authors: B
authors: Czerniak
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D012307:Risk Factors; D015398:Signal Transduction; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor