title: Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis.
abstract: Amyloids are insoluble fibrous protein aggregates which, when abnormally accumulated in the body, can result in amyloidosis and various neurodegenerative diseases. In this work, we describe a new approach to the asymptotic solution of the master equation of amyloid fiber aggregations. It is found that four distinct and successive stages (lag phase, exponential growth phase, breaking phase, and static phase) dominate the fiber formation process. On the basis of the distinctive power-law dependence of the half-time and apparent growth rate of the fiber formation on the initial protein concentration, we propose a novel classification for amyloid proteins theoretically.
authors: Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, Michigan 48109, USA.
authors: Liu
authors: L
authors: Hong
authors: Xianghong
authors: X
authors: Qi
authors: Yang
authors: Y
authors: Zhang
mesh_terms: D000682:Amyloid / Q000032:analysis* / Q000737:chemistry*; D007700:Kinetics; D012996:Solutions
chemical_list: D000682:Amyloid; D012996:Solutions