title: Familial amyotrophic lateral sclerosis, a historical perspective.
abstract: Amyotrophic lateral sclerosis is a fatal neurodegenerative disease of the upper and lower motor neuron of unknown etiology. Although a familial cause for this disease has been suspected early one, it is only in the past two decades that advances in modern genetics led to the identification of more than 10 genes linked to familial ALS and helped us understand some of the complex genetic and environmental interactions that may contribute to sporadic ALS. In this article, we chronologically summarize the genetic breakthroughs in familial and sporadic ALS and depict how it shaped our understanding of disease pathogenesis and our quest for rational therapies.
authors: Davee Department of Neurology and Clinical Neurosciences & Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, USA.
authors: T
authors: T
authors: Siddique
authors: S
authors: S
authors: Ajroud-Driss
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005192:Family Health; D059647:Gene-Environment Interaction; D055106:Genome-Wide Association Study; D006801:Humans; D009046:Motor Neurons / Q000378:metabolism* / Q000473:pathology; D009434:Neural Pathways / Q000378:metabolism* / Q000473:pathology; D010375:Pedigree; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D035703:Therapies, Investigational
chemical_list: C000606290:SOD1 protein, human; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1