title: The sparing effect of low-dose esmolol on sevoflurane during laparoscopic gynaecological surgery.
abstract: This double-blind, randomized, placebo-controlled study evaluated the sparing effect of esmolol on sevoflurane during laparoscopic gynaecological surgery in 54 patients between December 2009 and May 2010. The concentration of sevoflurane required to maintain adequate anaesthesia was  determined. Patients received either a 0.5 mg/kg esmolol intravenous loading dose followed by infusion of 30 μg/kg per min or an identical volume of normal saline (placebo). During surgery the input concentration of sevoflurane was adjusted every 5 min to maintain systolic blood pressure  within 15% of baseline and bispectral index at 50 - 60. Infusion of esmolol resulted in an 18.2% decrease in mean sevoflurane input concentration. Patients receiving esmolol had an earlier discharge from the postanaesthetic care unit and a lower mean fentanyl dose. In conclusion, intraoperative  esmolol infusion decreased both the requirement for sevoflurane and postoperative administration of fentanyl.
authors: Department of Anaesthesiology and Pain Medicine, Seoul St Mary's Hospital, Catholic Medical College, Seocho-gu, Seoul, Republic of Korea.
authors: Y E
authors: YE
authors: Moon
authors: W J
authors: WJ
authors: Hwang
authors: H J
authors: HJ
authors: Koh
authors: J Y
authors: JY
authors: Min
authors: J
authors: J
authors: Lee
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008738:Methyl Ethers; D008875:Middle Aged; D015999:Multivariate Analysis; D011412:Propanolamines; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D011412:Propanolamines; D000077149:Sevoflurane; C036604:esmolol