title: Engineered bacterially expressed polypeptides: assembly into polymer particles with tailored degradation profiles.
abstract: In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).
authors: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors: Denison H C
authors: DH
authors: Chang
authors: Angus P R
authors: AP
authors: Johnston
authors: Kim L
authors: KL
authors: Wark
authors: Kerry
authors: K
authors: Breheney
authors: Frank
authors: F
authors: Caruso
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism*; D004220:Disulfides / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D008863:Microspheres; D011099:Polyglutamic Acid / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004220:Disulfides; D004337:Drug Carriers; D011099:Polyglutamic Acid; D003545:Cysteine