title: Diversity oriented design of various benzophenone derivatives and their in vitro antifungal and antibacterial activities.
abstract: A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.
authors: Marine College, Shandong University, Weihai Wenhua West Road, No.180, Weihai 264209, China.
authors: Li
authors: L
authors: Sun
authors: Jie
authors: J
authors: Wu
authors: Min
authors: M
authors: Luo
authors: Xiaoli
authors: X
authors: Wang
authors: Man
authors: M
authors: Pan
authors: Zhaopin
authors: Z
authors: Gou
authors: Dequn
authors: D
authors: Sun
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D015195:Drug Design; D005670:Fusarium / Q000187:drug effects; D009025:Morpholines / Q000138:chemical synthesis / Q000494:pharmacology; D010084:Oxidation-Reduction; D010935:Plant Diseases / Q000382:microbiology; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001577:Benzophenones; D009025:Morpholines