title: Asymmetric synthesis of β-adrenergic blockers through multistep one-pot transformations involving in situ chiral organocatalyst formation.
abstract: Two birds one stone: A new atom-economical one-pot approach to enantioselective chiral drug synthesis, involving in situ multistep organocatalyst formation and the application of the reaction for multistep sequential synthesis of β-adrenergic blockers is disclosed (see scheme).
authors: Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen, Germany.
authors: Shengwei
authors: S
authors: Wei
authors: Regina
authors: R
authors: Messerer
authors: Svetlana B
authors: SB
authors: Tsogoeva
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols