title: Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease.
abstract: Mounting evidence suggests that amyloid beta-induced impairments in synaptic plasticity that is accompanied by cognitive decline and dementia represent key pathogenic steps of Alzheimer's disease. In this study, we review recent advances in the study of the molecular and cellular mechanisms underlying Alzheimer's disease-associated synaptic dysfunction and memory deficits, and how these mechanisms could provide novel avenues for therapeutic intervention to treat this devastating neurodegenerative disease.
authors: Center for Neural Science, New York University, New York, New York, USA.
authors: Tao
authors: T
authors: Ma
authors: Center for Neural Science, New York University, New York, New York, USA.
authors: Eric
authors: E
authors: Klann
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides