title: Efficacy and safety of a porcine collagen sponge for cranial neurosurgery: a prospective case-control study.
abstract: OBJECTIVE
  The use of dural grafts is very useful when primary dural closure cannot be achieved. Our primary objective was to study the incidence of postoperative cerebrospinal fluid leak, including fistula and pseudomeningocele, and postoperative infection by comparing autologous material and a new collagen graft.
  
  
  METHODS
  A prospective nonrandomized study with a new collagen-based product derived from porcine cells (Peridry) was performed. It was used for dural replacement in 50 patients who underwent a variety of neurosurgical procedures requiring the use of a dural graft. These results were compared with a control group of 50 patients who were treated with autologous duraplasty material. The follow-up period was 3 months.
  
  
  RESULTS
  Postoperative overall cerebrospinal fluid fistula occurred in 6% of both groups. No patient in the collagen group developed any sort of infection. One patient in the control developed osteomyelitis in the bone flap.
  
  
  CONCLUSIONS
  The new collagen-based product derived from porcine cells (Peridry), compared with an autologous tissue, is safe, effective, easy to use, as well as time saving in cranial neurosurgery.
authors: Department of Neurosurgery, Santa Casa Hospital at Belo Horizonte, Minas Gerais, Brazil. rafabrand@gmail.com
authors: Rafael Augusto Castro Santiago
authors: RA
authors: Brandão
authors: Bruno Silva
authors: BS
authors: Costa
authors: Marcos Antonio
authors: MA
authors: Dellaretti
authors: Gervásio Teles C
authors: GT
authors: de Carvalho
authors: Marcello Penholate
authors: MP
authors: Faria
authors: Atos Alves
authors: AA
authors: de Sousa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000941:Antigens / Q000737:chemistry; D001684:Biological Dressings; D016022:Case-Control Studies; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use; D003399:Craniotomy / Q000295:instrumentation*; D004388:Dura Mater / Q000637:transplantation; D005260:Female; D005402:Fistula / Q000453:epidemiology; D005612:Freeze Drying; D006801:Humans; D007223:Infant; D008297:Male; D008588:Meningocele / Q000517:prevention & control; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation*; D010019:Osteomyelitis / Q000453:epidemiology; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013524:Surgical Flaps / Q000473:pathology; D015503:Surgical Sponges; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control; D013552:Swine; D055815:Young Adult
chemical_list: D000941:Antigens; D003094:Collagen