title: Biomarkers for microglial activation in Alzheimer's disease.
abstract: Intensive research over the last decades has provided increasing evidence for neuroinflammation as an integral part in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Inflammatory responses in the central nervous system (CNS) are initiated by activated microglia, representing the first line of the innate immune defence of the brain. Therefore, biochemical markers of microglial activation may help us understand the underlying mechanisms of neuroinflammation in AD as well as the double-sided qualities of microglia, namely, neuroprotection and neurotoxicity. In this paper we summarize candidate biomarkers of microglial activation in AD along with a survey of recent neuroimaging techniques.
authors: Clinical Neurochemistry Laboratory, Department of Neurochemistry and Psychiatry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 43180 Mölndal, Sweden.
authors: Ronald
authors: R
authors: Lautner
authors: Niklas
authors: N
authors: Mattsson
authors: Michael
authors: M
authors: Schöll
authors: Kristin
authors: K
authors: Augutis
authors: Kaj
authors: K
authors: Blennow
authors: Bob
authors: B
authors: Olsson
authors: Henrik
authors: H
authors: Zetterberg