title: [A case of Oguchi disease with disappearance of golden tapetal-like fundus reflex after vitreous resection].
abstract: BACKGROUND
  Oguchi disease is a form of congenital stationary night-blindness characterized by a golden tapetal fundus reflex. This reflex is known to disappear in the dark-adapted state ("Mizuo-Nakamura phenomenon"). The origin of the reflex is not clear. We report a case of Oguchi disease with the disappearance of the golden tapetal reflex after vitreous resection.
  
  
  METHODS
  An 80-year-old man was referred for rhegmatogenous retinal detachment of the left eye. Golden tapetal reflex was observed in both eyes. Negative b-wave in the electroretinogram and mutation in the SAG gene indicated Oguchi disease. Pars plana vitrectomy and posterior hyaloid membrane peeling were performed. The tapetal reflex in the all regions of the fundus in the operated eye disappeared after the retina was reattached. The reflex partially recovered 2 years after the operation.
  
  
  CONCLUSIONS
  It is suggested that the change in vitreo-retinal interface after a vitreous operation leads to the disappearance of the reflex. This report presents a hypothesis on the origin of the golden tapetal reflex in Oguchi disease.
authors: Department of Ophthalmology, Kobe City Medical Center General Hospital, 2-1-1 Minatojimaminamimachi, Chuo-ku, Kobe-shi, Hyogo-ken 650-0047, Japan. mkuroda-kyt@umin.net
authors: Masako
authors: M
authors: Kuroda
authors: Yasuhiko
authors: Y
authors: Hirami
authors: Akihiro
authors: A
authors: Nishida
authors: Zi-Bing
authors: ZB
authors: Jin
authors: Chie
authors: C
authors: Ishigami
authors: Masayo
authors: M
authors: Takahashi
authors: Yasuo
authors: Y
authors: Kurimoto
mesh_terms: D000369:Aged, 80 and over; D015785:Eye Diseases, Hereditary; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D009755:Night Blindness / Q000503:physiopathology / Q000601:surgery*; D012021:Reflex, Abnormal / Q000502:physiology*; D014821:Vitrectomy