title: Platelet associated IgG may be related with thrombocytopenia in patients with myelodysplastic syndromes.
abstract: Thrombocytopenia is common in patients with myelodysplastic syndromes (MDS) and immune destruction of platelets could be an important factor for its occurrence. We prospectively analyzed platelet-associated IgG (PAIgG) through platelet immunofluorescence test (PIFT), mean platelet volume (MPV), platelet size deviation width (PDW) and glycocalicin index (GCI) of 54 patients with MDS, classified according to the International Prognostic Scoring System (IPSS). Thrombocytopenia (platelet count<100×10(9)/L) was correlated with a higher amount of PAIgG, significantly higher MPV and increased GCI. In addition, worse prognosis IPSS groups were associated with a higher positivity of PIFT, which could be indicative of advanced disease.
authors: Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil. mona@unicamp.br
authors: Simone Cristina Olenscki
authors: SC
authors: Gilli
authors: Samuel
authors: S
authors: de Souza Medina
authors: Vagner
authors: V
authors: de Castro
authors: Luís Gustavo Romani
authors: LG
authors: Fernandes
authors: Sara Teresinha Olalla
authors: ST
authors: Saad
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications*; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D013921:Thrombocytopenia / Q000453:epidemiology / Q000209:etiology*
chemical_list: D007074:Immunoglobulin G