title: Bicelles: lipid nanostructured platforms with potential dermal applications.
abstract: Bicelles emerge as promising membrane models, and because of their attractive combination of lipid composition, small size and morphological versatility, they become new targets in skin research. Bicelles are able to modify skin biophysical parameters and modulate the skin's barrier function, acting to enhance drug penetration. Because of their nanostructured assemblies, bicelles have the ability to penetrate through the narrow intercellular spaces of the stratum corneum of the skin to reinforce its lipid lamellae. The bicelle structure also allows for the incorporation of different molecules that can be carried through the skin layers. All of these characteristics can be modulated by varying the lipid composition and experimental conditions. The remarkable versatility of bicelles is their most important characteristic, which makes their use possible in various fields. This system represents a platform for dermal applications. In this review, an overview of the main properties of bicelles and their effects on the skin are presented.
authors: Dept. of Chemical Technology and Surfactants, Institut de Química Avançada de Catalunya-I.Q.A.C., Consejo Superior de Investigaciones Científicas-C.S.I.C., C/Jordi Girona 18-26, 08034 Barcelona, Spain. l.barbosa.barros@ub.edu
authors: Lucyanna
authors: L
authors: Barbosa-Barros
authors: Gelen
authors: G
authors: Rodríguez
authors: Clara
authors: C
authors: Barba
authors: Mercedes
authors: M
authors: Cócera
authors: Laia
authors: L
authors: Rubio
authors: Joan
authors: J
authors: Estelrich
authors: Carmen
authors: C
authors: López-Iglesias
authors: Alfonso
authors: A
authors: de la Maza
authors: Olga
authors: O
authors: López
mesh_terms: D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures; D012867:Skin
chemical_list: D008055:Lipids