title: A pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features: a case report.
abstract: Spinal cord tumors are rare in children. We report a novel case of pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features. Clinically, the patient presented at the age of 3 years with motor deficit and urinary incontinence, and MRI demonstrated multilocular cystic lesions in the thoracic spine. Histologically the tumor consisted of solid, sheet-like components and branching papillary structures, and immunohistochemistry demonstrated positive reactivity for epithelial membrane antigen, cytokeratins (7, AE1/3, CAM5.2), E-cadherin and transthyretin, and negativity for GFAP, S-100 protein, synaptophysin and neurofilament. These histological and immunohistochemical findings appeared to be unique, and were not compatible with the features of classical ependymoma or choroid plexus papilloma. The clinical behavior, characterized by relatively rapid tumor regrowth after surgical resection and a relatively high MIB-1 labeling index, suggest that this tumor might have had moderate malignant potential. This pediatric case appears to be particularly informative with regard to the tumor biology or tumorigenesis of intramedullary spinal cord tumor with unusual solid-cystic and papillary features.
authors: Division of Molecular Pathology, Department of Microbiology and Pathology, Tottori University Faculty of Medicine, Yonago, Japan.
authors: Takeshi
authors: T
authors: Iwasaki
authors: Masako
authors: M
authors: Kato
authors: Yasushi
authors: Y
authors: Horie
authors: Shinsuke
authors: S
authors: Kato
authors: Keiichi
authors: K
authors: Akatsuka
authors: Takashi
authors: T
authors: Watanabe
authors: Satoshi
authors: S
authors: Kuwamoto
authors: Ichiro
authors: I
authors: Murakami
authors: Kazuhiko
authors: K
authors: Hayashi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013120:Spinal Cord Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013595:Syringomyelia / Q000473:pathology; D013904:Thoracic Vertebrae
chemical_list: D014408:Biomarkers, Tumor