title: Additive-free nucleophilic addition of imidazolines and imidazoles to haloacetylenes.
abstract: Nucleophilic addition of imidazolines to 1-halo-1-alkynes takes place by simple heating in DMF without any additives to give (Z)-N-(1-halo-1-alken-2-yl)imidazolines in good yield and in a highly regio- and stereoselective manner. These reaction conditions are also valid for the similar addition of imidazoles.
authors: Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan.
authors: Masahito
authors: M
authors: Yamagishi
authors: Jun
authors: J
authors: Okazaki
authors: Ken
authors: K
authors: Nishigai
authors: Takeshi
authors: T
authors: Hata
authors: Hirokazu
authors: H
authors: Urabe
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D048288:Imidazolines / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007093:Imidazoles; D048288:Imidazolines; D002713:Chlorine; D007455:Iodine; D000114:Acetylene; D001966:Bromine