title: Identification and chemoprevention in subjects at moderate risk of colorectal cancer.
abstract: The risk of developing colorectal cancer (CRC) depends on both genetic factors and lifestyle-related factors. Chemoprevention's true contribution is dependent on lifetime CRC risk. There are clinical situations where chemoprevention for CRC is undoubtedly useful. There are other situations where the risk of CRC seems to be only moderately increased and in these situations, the true contribution of chemoprevention is questionable. A few specific studies assessing the effect of chemopreventive agents in these situations are available. In the present article, we will try to better define these particular situations and discuss the risk quantification and the expected chemoprevention contribution.
authors: Department of Gastroenterology, AP-HP, Avicenne Hospital, 125 rue de Stalingrad, Bobigny, France. robert.benamouzig@avc.aphp.fr
authors: Robert
authors: R
authors: Benamouzig
authors: Bernard
authors: B
authors: Uzzan
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D018579:Patient Selection; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior
chemical_list: D016588:Anticarcinogenic Agents