title: Rapid emergence and spread of OXA-48-producing carbapenem-resistant Enterobacteriaceae isolates in Belgian hospitals.
abstract: During a polymerase chain reaction (PCR)-based surveillance study of β-lactam resistance, 19 OXA-48-positive enterobacterial isolates were detected at nine Belgian hospitals from January 2010 to April 2011. Most cases were presumed to have been locally acquired and were detected in patients who had not travelled abroad. Clonally related outbreaks occurred in two different cities. The majority of isolates co-produced several β-lactamases as well as non-β-lactam resistance genes. This report highlights the rapid emergence and spread of OXA-48-producing Enterobacteriaceae in Belgium.
authors: National Reference Laboratory for Antibiotic Resistance Monitoring in Gram-negative Bacteria, CHU Mont-Godinne, Université Catholique de Louvain, 1 avenue Dr Gaston Thérasse, B-5530 Yvoir, Belgium. youri.glupczynski@skynet.be
authors: Youri
authors: Y
authors: Glupczynski
authors: Te-Din
authors: TD
authors: Huang
authors: Warda
authors: W
authors: Bouchahrouf
authors: Roberta
authors: R
authors: Rezende de Castro
authors: Caroline
authors: C
authors: Bauraing
authors: Michèle
authors: M
authors: Gérard
authors: Anne-Marie
authors: AM
authors: Verbruggen
authors: Ariane
authors: A
authors: Deplano
authors: Olivier
authors: O
authors: Denis
authors: Pierre
authors: P
authors: Bogaerts
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001530:Belgium / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases