title: Stability of Boolean and continuous dynamics.
abstract: Regulatory dynamics in biology is often described by continuous rate equations for continuously varying chemical concentrations. Binary discretization of state space and time leads to Boolean dynamics. In the latter, the dynamics has been called unstable if flip perturbations lead to damage spreading. Here, we find that this stability classification strongly differs from the stability properties of the original continuous dynamics under small perturbations of the state vector. In particular, random networks of nodes with large sensitivity yield stable dynamics under small perturbations.
authors: Bioinformatics Group, Institute for Computer Science, University of Leipzig, Härtelstraße 16-18, D-04107 Leipzig, Germany. fakhteh@bioinf.uni-leipzig.de
authors: Fakhteh
authors: F
authors: Ghanbarnejad
authors: Konstantin
authors: K
authors: Klemm
mesh_terms: D008954:Models, Biological; D011336:Probability; D013997:Time Factors