title: Ocular surface squamous neoplasia in an anophthalmic socket 60 years after enucleation.
abstract: Ocular surface squamous cell neoplasia in an anophthalmic socket is an exceptionally rare occurrence. We report a 62-year-old white man who had his left eye enucleated at age 2 and developed an invasive squamous cell carcinoma 60 years later. He received multiple treatments, including excisional biopsy, topical mitomycin C chemotherapy, cryotherapy, and finally exenteration. We review the literature to evaluate the clinical characteristics, time of onset following enucleation, treatment, and outcome of previously reported cases. Our case emphasizes the importance of a thorough examination of the anophthalmic socket, including upper and lower lid eversion.
authors: Department of Cornea, External Disease and Refractive Surgery, The Cleveland Clinic, Cleveland, Ohio, USA.
authors: Edgar M
authors: EM
authors: Espana
authors: Mark
authors: M
authors: Levine
authors: Lynn
authors: L
authors: Schoenfield
authors: Arun D
authors: AD
authors: Singh
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000628:therapy; D017679:Cryotherapy; D015353:Eye Enucleation; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009918:Orbital Neoplasms / Q000473:pathology* / Q000628:therapy