title: [Research progress of zebrafish used in drug metabolism].
abstract: Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.
authors: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Qiu-xia
authors: QX
authors: Chen
authors: Su
authors: S
authors: Zeng
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000378:metabolism; D008658:Inactivation, Metabolic; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D000077297:Pregnane X Receptor; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism; D013723:Teratogens / Q000633:toxicity; D015262:Xenobiotics / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*; D000099148:UGT1A1 Enzyme
chemical_list: D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D004364:Pharmaceutical Preparations; D000072317:Polychlorinated Dibenzodioxins; D000077297:Pregnane X Receptor; D018336:Receptors, Aryl Hydrocarbon; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013723:Teratogens; D015262:Xenobiotics; D000099148:UGT1A1 Enzyme