title: Iridoids from the roots of Valeriana jatamansi and their biological activities.
abstract: A new iridoid, jatamandoid A (1), and four known analogues (2-5) were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). Five compounds were evaluated and compounds 1, 2 and 5 showed moderate neuroprotective effects against MPP(+)-induced neuronal SH-SY5Y cell death.
authors: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 94 Weijin Road, Tianjin, P.R. China.
authors: Jing
authors: J
authors: Xu
authors: Ping
authors: P
authors: Guo
authors: Yuanqiang
authors: Y
authors: Guo
authors: Lingzhi
authors: L
authors: Fang
authors: Yushan
authors: Y
authors: Li
authors: Zhanping
authors: Z
authors: Sun
authors: Liping
authors: L
authors: Gui
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D039823:Iridoids / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014632:Valerian / Q000737:chemistry*
chemical_list: D039823:Iridoids; D018696:Neuroprotective Agents; C000590675:jatamandoid A