title: Programmatic impact of using QuantiFERON®-TB Gold in routine contact investigation activities.
abstract: OBJECTIVE
  To retrospectively assess the proportion of contacts tested with QuantiFERON ® -TB Gold (QFT-G) compared to the tuberculin skin test (TST) who were successfully evaluated and treated for latent tuberculosis infection (LTBI), and to assess the correlation of positive  test results with measures of TB exposure.
  
  
  METHODS
  Contacts of culture-confirmed pulmonary TB cases reported to the San Francisco Department of Public Health between 1 March 2005 and 31 December 2007 were included.
  
  
  RESULTS
  Of 1291 contacts meeting the eligibility criteria, 641 (50%)  were tested with QFT-G and 650 (50%) with TST. Contacts tested with QFT-G were more likely to complete evaluation (64% vs. 56%, OR(adj ) = 1.52, 95%CI 1.12-2.06). Infected contacts started (89% vs. 72%, OR(adj) = 5.18, 95%CI 2.10-14.18) and completed (70% vs.  53%, OR(adj) = 3.37, 95%CI 1.78-6.56) LTBI treatment more often in the group tested with QFT-G. Positive QFT-G results, but not positive TST results, correlated with the intensity, proximity and duration of TB exposure in foreign-born subjects.
  
  
  CONCLUSIONS
  More contacts  were successfully evaluated and treated for LTBI when screened with QFT-G compared to TST. Measures of exposure correlated better with QFT-G-positive results and, therefore, appropriately identified high-risk contacts for TB prevention.
authors: Tuberculosis Control Section, Department of Public Health, City and County of San Francisco, San Francisco General Hospital, Ward 94 1001 Potrero Ave, San Francisco, CA 94110, USA. Jennifer.Grinsdale@sfdph.org
authors: J A
authors: JA
authors: Grinsdale
authors: C S
authors: CS
authors: Ho
authors: H
authors: H
authors: Banouvong
authors: L M
authors: LM
authors: Kawamura
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D016358:Contact Tracing; D005260:Female; D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods*; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D012189:Retrospective Studies; D014374:Tuberculin Test / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents