title: Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML.
abstract: Improved outcome of acute myeloid leukemia (AML) depends on the better differentiation of subtypes to predict treatment response and the identification of new target for treatment. In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis.
authors: Division of Hematology and Hemotherapy, UNIFESP/Escola Paulista de Medicina, Rua Botucatu740, 3º andar, São Paulo CEP: 04023-900, Brazil.
authors: Ana Rosa S
authors: AR
authors: Costa
authors: Sintia I
authors: SI
authors: Belangero
authors: Maria Isabel
authors: MI
authors: Melaragno
authors: Maria de Lourdes
authors: Mde L
authors: Chauffaille
mesh_terms: D059786:Abnormal Karyotype; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction