title: Regulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis.
abstract: There is growing body of evidence that nitric oxide (NO)-cGMP-PKG signaling plays a central role in negative regulation of cardiovascular (CV) responses and its disorders through suppressed Ca(2+) dynamics. Other lines of evidence also reveal the stimulatory effects of this signaling on some CV functions. Recently, transient receptor potential (TRP) channels have received much attention as non-voltage-gated Ca(2+) channels involved in CV physiology and pathophysiology. Available information suggests that these channels undergo both inhibition and activation by NO via PKG-mediated phosphorylation and S-nitrosylation, respectively, and also act as upstream regulators to promote endothelial NO production. This review summarizes the roles of NO-cGMP-PKG signaling pathway, particularly in regulating TRP channel functions with their associated physiology and pathophysiology.
authors: Department of Physiology, Graduate School of Medcial Sciences, Fukuoka University, Fukuoka, Japan. inouery@fukuoka-u.ac.jp
authors: Ryuji
authors: R
authors: Inoue
authors: Juan
authors: J
authors: Shi
authors: Zhong
authors: Z
authors: Jian
authors: Yuko
authors: Y
authors: Imai