title: Effects of erythropoietin on the bone microenvironment.
abstract: It has been well established that blood and bone share a unique, regulatory relationship with one another, though the specifics of this relationship still remain unanswered. Erythropoietin (Epo) is known primarily for its role as a hematopoietic hormone. However, after the discovery of Epo receptor outside the hematopoietic tissues, Epo has been avidly studied for its possible nonhematopoietic effects. It has been proposed that Epo interacts with bone both directly, by activating bone marrow stromal cells, and indirectly, through signaling pathways on hematopoietic stem cells. Yet, the role of Epo in regulating skeletal maintenance and regeneration remains controversial. Here, we review the current state of knowledge pertaining to the effects of Epo on the skeleton.
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109-1078, USA.
authors: S J
authors: SJ
authors: McGee
authors: A M
authors: AM
authors: Havens
authors: Y
authors: Y
authors: Shiozawa
authors: Y
authors: Y
authors: Jung
authors: R S
authors: RS
authors: Taichman
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D002478:Cells, Cultured; D004921:Erythropoietin / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010012:Osteogenesis / Q000187:drug effects; D011817:Rabbits
chemical_list: D004921:Erythropoietin