title: Two successful pregnancies in a patient with chemotherapy-induced ovarian failure while on hormone replacement therapy.
abstract: Chemotherapeutic agents administered for the treatment of malignancies can result in the incidence of premature ovarian failure (POF). Ovarian failure is reflected by elevated serum follicle-stimulating hormone (FSH) levels that may reach menopausal levels, at which the chances of a pregnancy are considered extremely rare. We report a case of a 26-year-old female who experienced two successful pregnancies, despite her diagnosis with chemotherapy-induced POF. This case suggests that patients who suffer from POF secondary to chemotherapy might still retain enough ovarian function with good quality oocytes that could support a healthy pregnancy.
authors: Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. gg02@aub.edu.lb
authors: Ghina
authors: G
authors: Ghazeeri
authors: Johnny
authors: J
authors: Awwad
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D009918:Orbital Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D012208:Rhabdomyosarcoma / Q000188:drug therapy* / Q000473:pathology