title: Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice.
abstract: Whether or not the oral intake of metals such as aluminium (Al) and zinc (Zn) is a risk for Alzheimer's disease (AD) has been a matter of controversy. Lack of AD pathology in patients with Al encephalopathy indicates Al does not cause AD. On the other hand, some epidemiological studies have suggested high Al increases the occurrence of AD. Our purpose is to test if high Al in drinking water is a risk factor for AD. We administered Al and Zn in drinking water to Tg2576, a transgenic mouse model for amyloid β-protein (Aβ) deposition with the Aβ precursor protein (AβPP) mutations (K670N/M671L), and Tg2576/tau(P301L), a model for Aβ and tau deposition. Deionized water was given to the control Tg2576 and Tg2576/tau. After administration for 4-10 months of approximately 100 mg/kg body weight Al or Zn per day, we were not able to find by quantitative immunohistochemical analyses differences in the deposition of Aβ and tau between the treated and untreated groups. Nor did the Al or Zn treatment affect the amount of soluble Aβ and Aβ*56, an Aβ oligomer, measured by ELISA or immunoblot. The oral intake of excess Al or Zn does not accelerate AD pathology in the transgenic mouse models for Aβ and tau accumulation. Such results do not seem to support the notion that excessive oral intake of Al or Zn is a risk factor for AD.
authors: Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. akiyama-hr@igakuken.or.jp
authors: Haruhiko
authors: H
authors: Akiyama
authors: Masato
authors: M
authors: Hosokawa
authors: Fuyuki
authors: F
authors: Kametani
authors: Hiromi
authors: H
authors: Kondo
authors: Momoko
authors: M
authors: Chiba
authors: Masako
authors: M
authors: Fukushima
authors: Takeshi
authors: T
authors: Tabira
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D004195:Disease Models, Animal; D060766:Drinking Water / Q000009:adverse effects / Q000737:chemistry; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D015032:Zinc / Q000633:toxicity*
chemical_list: D060766:Drinking Water; D000535:Aluminum; D015032:Zinc