title: Genomewide association studies in cardiovascular disease--an update 2011.
abstract: BACKGROUND
  Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.
  
  
  BACKGROUND
  We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome").
  
  
  CONCLUSIONS
  Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.
authors: Department of General and Interventional Cardiology, The University Heart Center at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Tanja
authors: T
authors: Zeller
authors: Stefan
authors: S
authors: Blankenberg
authors: Patrick
authors: P
authors: Diemert
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D059467:Transcriptome / Q000235:genetics; D000099183:Sortilin
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D000099183:Sortilin