title: Pericytes and myofibroblasts reaction in experimental thermal third degree skin burns.
abstract: Pericytes and myofibroblasts are two types of connective cells that appear in large quantities in reparative processes. In order to evaluate their response and any relationships between them, we have inflicted third degree skin burns to seven groups of five common Wistar rats each from which we sampled granulation tissue at three days interval for histological and immunohistochemical studies. Alpha-SMA and CD34 antibodies revealed that granulation tissue myofibroblasts do not express CD34 and do not arise from pericytes. The parallel arrangement of myofibroblasts in relation to the burned wound surface suggests that their main function is mechanical traction on granulation tissue and wound edges.
authors: Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania.
authors: Florina Carmen
authors: FC
authors: Popescu
authors: Cristina Jana
authors: CJ
authors: Busuioc
authors: G D
authors: GD
authors: Mogoşanu
authors: O T
authors: OT
authors: Pop
authors: H
authors: H
authors: Pârvănescu
authors: I
authors: I
authors: Lascăr
authors: Corina Ivona
authors: CI
authors: Nicolae
authors: L
authors: L
authors: Mogoantă
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology*; D006097:Granulation Tissue / Q000473:pathology; D008297:Male; D058628:Myofibroblasts / Q000473:pathology*; D020286:Pericytes / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology*; D014945:Wound Healing