title: Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population.
abstract: BACKGROUND
  Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population.
  
  
  RESULTS
  We conducted a two-stage case-control study in a Chinese Han population. The first-stage, consisting of 1,376 CHD cases and 1,376 sex and age- frequency matched controls, examined 5 novel lipid-associated single-nucleotide polymorphisms (SNPs) identified from GWAS among Caucasians in relation to CHD risk in Chinese. We then validated significant SNPs in the second-stage, consisting of 1,269 cases and 2,745 controls. We also tested associations between SNPs within the five novel loci and blood lipid levels in 4,121 controls. We identified two novel SNPs (rs599839 in CELSR2-PSRC1-SORT1 and rs16996148 in NCAN-CILP2) that were significantly associated with reduced CHD risk in Chinese (odds ratios (95% confidence intervals) in the dominant model 0.76 (0.61-0.90; P = 0.001), 0.67 (0.57-0.77; P = 3.4×10(-8)), respectively). Multiple linear regression analyses using dominant model showed that rs599839 was significantly associated with decreased LDL levels (P = 0.022) and rs16996148 was significantly associated with increased LDL and HDL levels (P = 2.9×10(-4) and 0.001, respectively).
  
  
  CONCLUSIONS
  We identified two novel SNPs (rs599839 and rs16996148) at newly identified lipid-associated loci that were significantly associated with CHD susceptibility in a Chinese Han population.
authors: Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors: Li
authors: L
authors: Zhou
authors: Hu
authors: H
authors: Ding
authors: Xiaomin
authors: X
authors: Zhang
authors: Meian
authors: M
authors: He
authors: Suli
authors: S
authors: Huang
authors: Yujun
authors: Y
authors: Xu
authors: Ying
authors: Y
authors: Shi
authors: Guanglin
authors: G
authors: Cui
authors: Longxian
authors: L
authors: Cheng
authors: Qing K
authors: QK
authors: Wang
authors: Frank B
authors: FB
authors: Hu
authors: Daowen
authors: D
authors: Wang
authors: Tangchun
authors: T
authors: Wu
mesh_terms: D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics* / Q000378:metabolism*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*