title: Case report: identical twins revealing discordant hypodontia. The rationale of dental arch differences in monozygotic twins.
abstract: BACKGROUND
  While it is generally accepted that monozygotic (MZ) twins are identical with respect to inherited traits, because they share 100% of their genetic material, clinical findings and scientific evidence does not support this belief. In addition to environmental factors and stochastic developmental events, a number of genetic mechanisms, detectable by new techniques in molecular genetics, explain the differences frequently observed in MZ twins.
  
  
  METHODS
  Nine-year-old twin girls requested treatment for a dental malocclusion. Their facial and occlusal features were very similar. Panoramic radiographs revealed hypodontia of two permanent teeth in one twin (35 and 45) and of only one tooth in the other (45). An incorrect diagnosis of dizygosity (DZ) had been made at birth based on the presence of two amniotic sacs. Despite discordance in the dental complement of both girls their orthodontist suspected that the twins might be identical. A genetic study performed by quantitative fluorescence-polymerase chain reaction (QFPCR) analysis of chromosomes 13, 15, 16, 18, 21, 22, and X confirmed that the twins were MZ.
  
  
  CONCLUSIONS
  Discordances in dental complement between MZ twins are not uncommon and do not exclude monozygosity.
authors: Dept Orthodontics, Jiménez Díaz Foundation, Autonomous University, Madrid, Spain. memoriavarela@gmail.com
authors: M
authors: M
authors: Varela
authors: M J
authors: MJ
authors: Trujillo-Tiebas
authors: P
authors: P
authors: Garcia-Camba
mesh_terms: D000848:Anodontia / Q000235:genetics*; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D059785:Karyotype; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D014430:Twins, Monozygotic