title: Palladium-catalyzed cascade cyclization of ynamides to azabicycles.
abstract: Cascade reactions: A modular assembly of azabicycles by using a cascade cyclization/Suzuki coupling/6π-electrocyclization of bromoenynamides is reported. The reaction offers a wide substituent scope on the bicyclic aminodiene products, which can be selectively oxidized as a general approach to aromatic azabicycles.
authors: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors: Rebecca L
authors: RL
authors: Greenaway
authors: Craig D
authors: CD
authors: Campbell
authors: Oliver T
authors: OT
authors: Holton
authors: C Adam
authors: CA
authors: Russell
authors: Edward A
authors: EA
authors: Anderson
mesh_terms: D000577:Amides / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D053961:Azabicyclo Compounds; D006842:Hydrocarbons, Brominated; D010165:Palladium