title: Electrospun polylactide/poly(ethylene glycol) hybrid fibrous scaffolds for tissue engineering.
abstract: The biodegradable polylactide/poly(ethylene glycol) (PLA/PEG) hybrid membranes were fabricated via electrospinning of PLA/PEG solution. Their structures and properties were investigated by scanning electron microscopy, differential scanning calorimetry, and water contact angle. In vitro hydrolytic degradation showed that PEG content influenced the degradation rate of the PLA/PEG hybrid mats. The mechanical property was measured by tensile test and the result revealed that the addition of PEG had an obvious plasticization on PLA matrix. In-vitro biocompatibility was investigated by culturing cell on the scaffolds and MTT assay. The results indicated that the cell could attach and proliferate on the membranes, so confirmed that the PLA/PEG hybrid membrane had good biocompatibility, and it could be a promising biomaterial for tissue engineering applications.
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China; Orthopedics department of West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors: Bei-Yu
authors: BY
authors: Wang
authors: Shao-Zhi
authors: SZ
authors: Fu
authors: Pei-Yan
authors: PY
authors: Ni
authors: Jing-Rong
authors: JR
authors: Peng
authors: Lan
authors: L
authors: Zheng
authors: Feng
authors: F
authors: Luo
authors: Hao
authors: H
authors: Liu
authors: Zhi-Yong
authors: ZY
authors: Qian
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006868:Hydrolysis; D051379:Mice; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D014867:Water; D011092:Polyethylene Glycols