title: Hyperactivity induced by prenatal BrdU exposure across several experimental conditions.
abstract: Behavioral results are sometimes not reproducible even in the positive controls of developmental neurotoxicity (DNT) tests. Effects of several factors on the results should be considered. In the present paper, we examined the effects of strain-, gender-, and test-condition differences on BrdU-induced hyperactivity. The results showed that BrdU-induced hyperactivity was reproducible in two rat strains (SD and F344 rats), rodent species (rat and mouse), and both sexes. When the level of background sound in a test room was increased, the hyperactivity was persistent, resulting in no effect of background sound on BrdU-induced hyperactivity. Thus, we have demonstrated that the BrdU-animal model is a useful positive control via prenatal exposure to validate the entire DNT test process.
authors: Laboratory of Pathology, Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa. kuwagata.m@fdsc.or.jp
authors: Makiko
authors: M
authors: Kuwagata
authors: Tetsuo
authors: T
authors: Ogawa
authors: Katsumasa
authors: K
authors: Muneoka
authors: Seiji
authors: S
authors: Shioda
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D006948:Hyperkinesis / Q000196:embryology / Q000209:etiology*; D051379:Mice; D008813:Mice, Inbred ICR; D020258:Neurotoxicity Syndromes / Q000196:embryology / Q000209:etiology*; D009498:Neurotoxins / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013045:Species Specificity
chemical_list: D009498:Neurotoxins; D001973:Bromodeoxyuridine