title: Sugars and alcohol: IgA-associated renal diseases in alcoholic cirrhosis.
abstract: Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abnormal glycosylation of IgA1 N-linked as well as O-linked glycans. Furthermore, their work reveals unique biological properties of immune complexes in these patients as compared with those in patients with primary IgA nephropathy.
authors: Jan
authors: J
authors: Novak
authors: Bruce A
authors: BA
authors: Julian
mesh_terms: D000936:Antigen-Antibody Complex; D015703:Antigens, CD / Q000097:blood*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007668:Kidney / Q000276:immunology*; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008297:Male; D011961:Receptors, Fc / Q000097:blood*
chemical_list: D000936:Antigen-Antibody Complex; D015703:Antigens, CD; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011961:Receptors, Fc