title: Bacterial effectors: learning on the fly.
abstract: A common defining characteristic of pathogenic bacteria is the expression of a repertoire of effector molecules that have been named virulence factors. These bacterial factors include a -variety of proteins, such as toxins that are internalized by receptors and translocate across endosomal membranes to reach the cytosol, as well as others that are introduced directly into the cell by means of bacterial secretory apparatuses. Given the importance of these effectors for understanding bacterial pathogenicity, significant effort has been made to dissect their molecular mechanisms of action and their respective roles during infection. Herein we will discuss how Drosophila have been used as a model system to study these important microbial effectors, and to understand their contribution to pathogenicity.
authors: INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, Toxines Microbiennes dans la relation hôte pathogènes, Cedex 3, F-06204, Nice, France. laurent.boyer@unice.fr
authors: Laurent
authors: L
authors: Boyer
authors: Nicholas
authors: N
authors: Paquette
authors: Neal
authors: N
authors: Silverman
authors: Lynda M
authors: LM
authors: Stuart
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001419:Bacteria / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000276:immunology; D004331:Drosophila melanogaster / Q000276:immunology / Q000382:microbiology; D020690:GTPase-Activating Proteins / Q000378:metabolism; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation; D037521:Virulence Factors / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D020690:GTPase-Activating Proteins; D037521:Virulence Factors; C109227:YopP protein, Yersinia; C080866:cagA protein, Helicobacter pylori; D020741:rho GTP-Binding Proteins