title: The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.
abstract: The role of specific members of the NF-κB family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-κB1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF(+) thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-κB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics.
authors: Burnet Institute, Centre for Immunology, Melbourne, Victoria, Australia. gugasyan@burnet.edu.au
authors: Raffi
authors: R
authors: Gugasyan
authors: Elisha
authors: E
authors: Horat
authors: Sarah A
authors: SA
authors: Kinkel
authors: Fiona
authors: F
authors: Ross
authors: George
authors: G
authors: Grigoriadis
authors: Daniel
authors: D
authors: Gray
authors: Meredith
authors: M
authors: O'Keeffe
authors: Stuart P
authors: SP
authors: Berzins
authors: Gabrielle T
authors: GT
authors: Belz
authors: Raelene J
authors: RJ
authors: Grumont
authors: Ashish
authors: A
authors: Banerjee
authors: Andreas
authors: A
authors: Strasser
authors: Dale I
authors: DI
authors: Godfrey
authors: Philip N
authors: PN
authors: Tsichlis
authors: Steve
authors: S
authors: Gerondakis
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology*; D016130:Immunophenotyping; D015847:Interleukin-4 / Q000096:biosynthesis; D016328:NF-kappa B / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D016328:NF-kappa B; D015847:Interleukin-4; D048049:Extracellular Signal-Regulated MAP Kinases