title: Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host.
abstract: Aspirin is an anti-inflammatory drug demonstrated to possess a tremendous anticancer potential. As progression of some tumors is influenced by sex hormones, we investigated if the antineoplastic action of aspirin shows gender dependence. Using a murine model of T-cell lymphoma, the present investigation was undertaken to study if the antitumor actions of aspirin against lymphoma cells display gender dimorphism. The findings of the present investigation indicate that aspirin administration to male and female tumor-bearing hosts resulted in gender dependent differential tumor growth retardation. Such gender dichotomy of aspirin's antitumor action was associated with a differential impact on cell cycle progression and expression of cell survival regulatory molecules. Aspirin administration was also found to modulate crucial parameters of tumor microenvironment, including contents of glucose, lactate and cell growth regulatory cytokines, in a gender specific manner. Aspirin was found to reverse estrogen-dependent augmentation of tumor cell survival in vitro. Taken together the results of the present study suggest that the antineoplastic action of aspirin is gender-dependent and should be considered in designing of gender-specific therapeutic applications of aspirin.
authors: School of Biotechnology, Banaras Hindu University, Varanasi, U.P., India.
authors: Anjani
authors: A
authors: Kumar
authors: Naveen Kumar
authors: NK
authors: Vishvakarma
authors: Alok Chandra
authors: AC
authors: Bharti
authors: Sukh Mahendra
authors: SM
authors: Singh
mesh_terms: D000728:Androgens / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012737:Sex Factors; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000728:Androgens; D000970:Antineoplastic Agents; D004967:Estrogens; D001241:Aspirin