title: Role of JNK in mammary gland development and breast cancer.
abstract: cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.
authors: Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors: Cristina
authors: C
authors: Cellurale
authors: Nomeda
authors: N
authors: Girnius
authors: Feng
authors: F
authors: Jiang
authors: Julie
authors: J
authors: Cavanagh-Kyros
authors: Shaolei
authors: S
authors: Lu
authors: David S
authors: DS
authors: Garlick
authors: Arthur M
authors: AM
authors: Mercurio
authors: Roger J
authors: RJ
authors: Davis
mesh_terms: D000818:Animals; D048708:Cell Growth Processes / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005260:Female; D015870:Gene Expression; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008321:Mammary Glands, Animal / Q000201:enzymology* / Q000254:growth & development*; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D008822:Mice, Transgenic; D048055:Mitogen-Activated Protein Kinase 8 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D048056:Mitogen-Activated Protein Kinase 9 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D048056:Mitogen-Activated Protein Kinase 9; D048055:Mitogen-Activated Protein Kinase 8