title: Study of the response of superoxide dismutase in mouse organs to radon using a new large-scale facility for exposing small animals to radon.
abstract: We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose-rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
authors: Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama 700-8558, Japan.
authors: Takahiro
authors: T
authors: Kataoka
authors: Akihiro
authors: A
authors: Sakoda
authors: Yuu
authors: Y
authors: Ishimori
authors: Teruaki
authors: T
authors: Toyota
authors: Yuichi
authors: Y
authors: Nishiyama
authors: Hiroshi
authors: H
authors: Tanaka
authors: Fumihiro
authors: F
authors: Mitsunobu
authors: Kiyonori
authors: K
authors: Yamaoka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D011886:Radon / Q000008:administration & dosage / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism / Q000528:radiation effects*; D013679:Technology, Radiologic / Q000295:instrumentation
chemical_list: D000975:Antioxidants; D013482:Superoxide Dismutase; D011886:Radon