title: Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
abstract: To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Peter
authors: P
authors: Broderick
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Daniel
authors: D
authors: Chubb
authors: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors: David C
authors: DC
authors: Johnson
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors: Niels
authors: N
authors: Weinhold
authors: German Cancer Research Center, Heidelberg, Germany.
authors: Asta
authors: A
authors: Försti
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Amy
authors: A
authors: Lloyd
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Bianca
authors: B
authors: Olver
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Yussanne
authors: Y
authors: Ma
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Sara E
authors: SE
authors: Dobbins
authors: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors: Brian A
authors: BA
authors: Walker
authors: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors: Faith E
authors: FE
authors: Davies
authors: University of Leeds, Leeds, UK.
authors: Walter A
authors: WA
authors: Gregory
authors: University of Leeds, Leeds, UK.
authors: J Anthony
authors: JA
authors: Childs
authors: Cytogenetics Group, Wessex Regional Cytogenetic Laboratory, Salisbury, UK.
authors: Fiona M
authors: FM
authors: Ross
authors: Royal Victoria Infirmary, Newcastle-on-Tyne, UK.
authors: Graham H
authors: GH
authors: Jackson
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors: Kai
authors: K
authors: Neben
authors: Institute of Human Genetics, University of Heidelberg, Germany.
authors: Anna
authors: A
authors: Jauch
authors: Institute of Human Genetics, University of Bonn, Germany.
authors: Per
authors: P
authors: Hoffmann
authors: Institute of Human Genetics, University of Bonn, Germany.
authors: Thomas W
authors: TW
authors: Mühleisen
authors: Institute of Human Genetics, University of Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Markus M
authors: MM
authors: Nöthen
authors: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Germany.
authors: Susanne
authors: S
authors: Moebus
authors: Molecular and Population Genetics, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
authors: Ian P
authors: IP
authors: Tomlinson
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.|National Centre of Tumour Diseases, Heidelberg, Germany.
authors: Hartmut
authors: H
authors: Goldschmidt
authors: German Cancer Research Center, Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors: Kari
authors: K
authors: Hemminki
authors: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors: Gareth J
authors: GJ
authors: Morgan
authors: Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.|Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors: Richard S
authors: RS
authors: Houlston
mesh_terms: D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D012307:Risk Factors
chemical_list: D017346:Protein Serine-Threonine Kinases; C570299:Ulk4 protein, human