title: Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer.
abstract: Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease.
authors: Department of Otorhinolaryngology, Virginia Commonwealth University, Richmond, VA, USA.
authors: Alexandros
authors: A
authors: Georgolios
authors: Anna
authors: A
authors: Eleftheriadou
authors: Anna
authors: A
authors: Batistatou
authors: Kostandinos
authors: K
authors: Charalabopoulos
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007473:Ion Channels; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008840:Microfilament Proteins; D009363:Neoplasm Proteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; C451410:FXYD5 protein, human; D007473:Ion Channels; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins