title: Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineering.
abstract: The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications.
authors: Seadev-FermenSys SAS, Technopole Brest Iroise, 185 rue René Descartes, Plouzané 29280, France.
authors: Karim
authors: K
authors: Senni
authors: INSERM U765, Faculté de Pharmacie, UMR-S765, Université Paris Descartes, Sorbonne Paris Cité, 4 avenue de l'Observatoire, Paris 75006, France.
authors: Jessica
authors: J
authors: Pereira
authors: Biochemistry Department, Faculty of Dental Surgery, Paris Descartes University, Montrouge 92120, France.
authors: Farida
authors: F
authors: Gueniche
authors: Laboratory of Biotechnology and Marine Molecules, Ifremer, Rue de l'Ile d'Yeu, BP 21105, Nantes Cedex 03 44311, France.
authors: Christine
authors: C
authors: Delbarre-Ladrat
authors: Laboratory of Biotechnology and Marine Molecules, Ifremer, Rue de l'Ile d'Yeu, BP 21105, Nantes Cedex 03 44311, France.
authors: Corinne
authors: 0000-0002-8930-9535
authors: C
authors: Sinquin
authors: Laboratory of Biotechnology and Marine Molecules, Ifremer, Rue de l'Ile d'Yeu, BP 21105, Nantes Cedex 03 44311, France.
authors: Jacqueline
authors: J
authors: Ratiskol
authors: Biochemistry Department, Faculty of Dental Surgery, Paris Descartes University, Montrouge 92120, France.
authors: Gaston
authors: G
authors: Godeau
authors: INSERM U765, Faculté de Pharmacie, UMR-S765, Université Paris Descartes, Sorbonne Paris Cité, 4 avenue de l'Observatoire, Paris 75006, France.|AP-HP, Biological Hematology Department, European Hospital Georges Pompidou, 20 rue Leblanc, Paris 75015, France.
authors: Anne-Marie
authors: AM
authors: Fischer
authors: INSERM U765, Faculté de Pharmacie, UMR-S765, Université Paris Descartes, Sorbonne Paris Cité, 4 avenue de l'Observatoire, Paris 75006, France.|AP-HP, Biological Hematology Department, European Hospital Georges Pompidou, 20 rue Leblanc, Paris 75015, France.
authors: Dominique
authors: D
authors: Helley
authors: Laboratory of Biotechnology and Marine Molecules, Ifremer, Rue de l'Ile d'Yeu, BP 21105, Nantes Cedex 03 44311, France.
authors: Sylvia
authors: S
authors: Colliec-Jouault
mesh_terms: D000464:Alginates / Q000494:pharmacology; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D000458:Cyanobacteria / Q000378:metabolism; D020723:Glucuronic Acid / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000494:pharmacology; D006801:Humans; D009792:Oceans and Seas; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D023822:Tissue Engineering
chemical_list: D000464:Alginates; D006025:Glycosaminoglycans; D006603:Hexuronic Acids; D011134:Polysaccharides; D020723:Glucuronic Acid; C007789:fucoidan