title: Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia.
abstract: The antioxidant, anti-α-glucosidase and anticholinesterase activity of the leaves and rhizomatous extract of Bergenia cordifolia were investigated. The rhizomes extract that showed a higher degree of 1,1-diphenyl-2-picrylhydrazyl radical scavenging and anti-α-glucosidase activity than reference compounds (rutin and acarbose respectively) were subjected to phytochemical analysis. The study revealed that previously unknown minor constituents from the plant, (+)-catechin 3-O-gallate, (+)-catechin 3,5-di-O-gallate and 1,2,4,6-tetra-O-galloyl-β-D-glucopyranoside, were the radical scavenging and anti-α-glucosidase principles. These compounds as well as the crude extracts were weak acetylcholienesterase inhibitors, suggesting a higher degree of selectivity against α-glucosidase enzyme. In comparison with the minor constituents, the previously known major constituents of the plant, bergenin and arbutin, were poor radical scavengers and enzyme inhibitors.
authors: Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Bari 'Aldo Moro', Via Orabona 4, 70125 Bari, Italy.
authors: Mariagrazia
authors: M
authors: Roselli
authors: Giovanni
authors: G
authors: Lentini
authors: Solomon
authors: S
authors: Habtemariam
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry; D002802:Cholinesterases / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*; D013379:Substrate Specificity; D000520:alpha-Glucosidases / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010851:Picrates; D002392:Catechin; C004931:1,1-diphenyl-2-picrylhydrazyl; D002802:Cholinesterases; D000520:alpha-Glucosidases