title: At-fault motor vehicle crash risk in elderly patients treated with antidepressants.
abstract: OBJECTIVE
  To assess whether antidepressant treatment is associated with a temporary increase in the risk of a motor vehicle crash among older adults.
  
  
  METHODS
  Population-based case-only time-to-event analysis.
  
  
  METHODS
  Data from transportation and healthcare databases for adults age 65 and older in Ontario, Canada, between January 1, 2000, and October 31, 2007. Consecutive adults who had a motor vehicle crash anytime following their 66th birthday.
  
  
  METHODS
  The primary exposure variable was treatment with antidepressant medication, and the primary outcome measure was a motor vehicle crash.
  
  
  RESULTS
  A total of 159,678 individuals had a crash during the study, of whom 7,393 (5%) received an antidepressant in the month prior to the crash. The hazard ratio (HR) of crash associated with second-generation antidepressants was 1.10 (95% confidence interval [CI]: 1.07-1.13, χ² = 41.77, df = 1, p <0.0001), adjusted for gender, license suspensions, and other medications, but the risk for first-generation antidepressants was not significant. The increased risk was restricted to those who were also concurrently prescribed a benzodiazepine (adjusted HR: 1.23, 95% CI: 1.17-1.28, χ² = 85.28, df = 1, p <0.0001) or a strong anticholinergic medication (adjusted HR: 1.63, 95% CI: 1.57-1.69, χ² = 627.31, df = 1, p <0.0001), and was confined to crashes where the patient was at fault. The increased risk was apparent for the first 3-4 months following initiation of an antidepressant and returned to baseline thereafter.
  
  
  CONCLUSIONS
  Prescriptions for second-generation antidepressants in older adults are associated with a modest increased risk of motor vehicle crashes, when combined with other medications that can impair cognition.
authors: University of Toronto, Toronto, Ontario, Canada. mark.rapoport@sunnybrook.ca
authors: Mark J
authors: MJ
authors: Rapoport
authors: Brandon
authors: B
authors: Zagorski
authors: Dallas
authors: D
authors: Seitz
authors: Nathan
authors: N
authors: Herrmann
authors: Frank
authors: F
authors: Molnar
authors: Donald A
authors: DA
authors: Redelmeier
mesh_terms: D000063:Accidents, Traffic / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001334:Automobile Driving / Q000706:statistics & numerical data*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D009864:Ontario; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D018680:Cholinergic Antagonists; D001569:Benzodiazepines