title: The haplotypes of TNFRSF17 polymorphisms are associated with colon cancer in a Korean population.
abstract: OBJECTIVE
  We previously found that the haplotypes of TNFRSF17 single nucleotide polymorphisms (SNPs) were associated with the susceptibility to inflammatory bowel disease on Korean population. The present study aimed to investigate whether the polymorphisms in the TNFRSF17 gene are associated with susceptibility to colorectal cancer (CRC).
  
  
  METHODS
  Genotype analysis in the TNFRSF17 SNPs was performed by high-resolution melting and TaqMan probe analysis, and the genotype and allele frequencies of TNFRSF17 SNPs were compared between the CRC patients and the healthy controls. The haplotype frequencies of TNFRSF17 for multiple loci were estimated using the expectation maximization algorithm.
  
  
  RESULTS
  Although, the genotype and allelic frequencies of these SNPs, in the colon cancer and rectal cancer patients, were not significantly different from those in the healthy controls, the genotype and allele frequency of g.2493G>A was significantly different between the healthy controls and the right colon cancer patients (P = 0.014 and 0.004, respectively). Moreover, the haplotypes frequencies in the healthy controls were significantly different from those in the colon cancer patients.
  
  
  CONCLUSIONS
  Our results suggest that TNFRSF17 may be a candidate gene associated with the pathogenesis of colon cancer, and the haplotypes of the TNFRSF17 polymorphisms might be one of the markers for colon cancer susceptibility.
authors: Department of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea.
authors: Soo-Cheon
authors: SC
authors: Chae
authors: Ji-In
authors: JI
authors: Yu
authors: Tai-Boong
authors: TB
authors: Uhm
authors: Sam-Yun
authors: SY
authors: Lee
authors: Dong-Baek
authors: DB
authors: Kang
authors: Jeong-Kyun
authors: JK
authors: Lee
authors: Won-Cheol
authors: WC
authors: Park
authors: Ki-Jung
authors: KJ
authors: Yun
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D053301:B-Cell Maturation Antigen / Q000235:genetics*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D053301:B-Cell Maturation Antigen; C086966:TNFRSF17 protein, human