title: A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues.
abstract: A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.
authors: Departamento de Química Orgánica, Universidad de Santiago, Santiago de Compostela, Spain.
authors: Olaia
authors: O
authors: Nieto-García
authors: Hugo
authors: H
authors: Lago-Santomé
authors: Fernando
authors: F
authors: Cagide-Fagín
authors: Juan Carlos
authors: JC
authors: Ortiz-Lara
authors: Ricardo
authors: R
authors: Alonso
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D008175:Lung Neoplasms / Q000188:drug therapy
chemical_list: C418326:7-deoxypancratistatin; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines