title: HSV-2: in pursuit of a vaccine.
abstract: Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.
authors: Department of Medicine, University of Washington, Seattle, Washington, USA. cjohnsto@u.washington.edu
authors: Christine
authors: C
authors: Johnston
authors: David M
authors: DM
authors: Koelle
authors: Anna
authors: A
authors: Wald
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D015897:Comorbidity; D004195:Disease Models, Animal; D005260:Female; D005544:Forecasting; D005727:Ganglia, Spinal / Q000821:virology; D015658:HIV Infections / Q000453:epidemiology; D006558:Herpes Genitalis / Q000151:congenital / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D018258:Herpesvirus 2, Human / Q000276:immunology*; D022283:Herpesvirus Vaccines; D006801:Humans; D057131:Immune Evasion; D018928:Immunity, Mucosal; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D016036:Seroepidemiologic Studies; D014611:Vaccination; D017735:Virus Latency; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines