title: Epstein-Barr virus-associated lymphoproliferative disorder presenting with classical Hodgkin lymphoma and developing as peripheral T-cell lymphoma 9 years later: a case report of composite lymphoma.
abstract: We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67-years-old and peripheral T-cell lymphoma, not otherwise specified (PTCL) at 76-years-old, and died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed with neoplastic cells. Hodgkin and Reed-Sternberg cells in the swollen lymph node were positive for CD30 and EBV-encoded RNA (EBER). PTCL cells in the skin tumor were positive for cytoplasmic CD3ε, CD4 and EBER. A rearrangement band of the T-cell receptor gene was detected in the skin tumor. This case is the first documented EBV-associated composite lymphoma composed of CHL and PTCL. The patient may show the possibility that both EBV infection and/or immunodeficiency induce the development of CHL and PTCL.
authors: Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan. oka-k@gb3.so-net.ne.jp
authors: Kuniyuki
authors: K
authors: Oka
authors: Reizo
authors: R
authors: Nagayama
authors: Shigeruko
authors: S
authors: Iijima
authors: Nobuo
authors: N
authors: Yonekawa
authors: Kunihiro
authors: K
authors: Hirosawa
authors: Yasushi
authors: Y
authors: Yatabe
authors: Naoyoshi
authors: N
authors: Mori
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology; D015897:Comorbidity; D058617:Composite Lymphoma / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000821:virology*