title: Pendrin function in airway epithelia.
abstract: The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also expressed in the bronchial epithelium following exposure to the T(H)2-type cytokines, interleukin (IL)-4 and IL-13. Expression of the transporter is also upregulated in bronchial asthma and chronic obstructive pulmonary disease. Both diseases involve respiratory inflammation leading to tissue destruction/remodeling and decreased airway function, and data so far indicate that increased pendrin expression and/or activity might contribute to their pathogenesis. In this review, we summarize data that have emerged within the past years aimed at revealing the role for pendrin in the airway epithelia.
authors: Institute of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria.
authors: Charity
authors: C
authors: Nofziger
authors: Silvia
authors: S
authors: Dossena
authors: Shoichi
authors: S
authors: Suzuki
authors: Kenji
authors: K
authors: Izuhara
authors: Markus
authors: M
authors: Paulmichl
mesh_terms: D001249:Asthma / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism; D015398:Signal Transduction; D000076988:Sulfate Transporters
chemical_list: D018793:Interleukin-13; D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters; D015847:Interleukin-4