title: Optimization of microalgal productivity using an adaptive, non-linear model based strategy.
abstract: The optimization of biomass and oil productivities in heterotrophic cultures of Auxenochlorella protothecoides was achieved using a non-linear model-based approach. A 10-fold increase in the average biomass productivity, and a 16-fold increase in the maximum productivity, was observed with respect to batch cultures as a result of the proposed optimization strategy. Final cell density in the optimized culture was 144 g/L (dry weight), with 49.4%w/w oil content. Maximum lipid productivity was 20.16 g/L d, achieved during the exponential growth phase at an average cell density of 86 g/L. Lipid productivity in the optimized microalgal culture was higher than previously reported values for other oleaginous microorganisms. Oil composition analysis showed that the oil has a high quality as biodiesel precursor. The higher productivity and excellent lipid profile of the optimized microalgal culture make A. protothecoides an exceptional source for biodiesel production and a potential source of single cell oil for other applications.
authors: Chemical and Materials Engineering Department, University of Alberta, Edmonton, Canada T6G 2V4.
authors: H
authors: H
authors: De la Hoz Siegler
authors: W C
authors: WC
authors: McCaffrey
authors: R E
authors: RE
authors: Burrell
authors: A
authors: A
authors: Ben-Zvi
mesh_terms: D056804:Biofuels / Q000382:microbiology*; D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods*; D049108:Cell Enlargement; D000460:Chlorophyta / Q000145:classification / Q000378:metabolism*; D003198:Computer Simulation; D050356:Lipid Metabolism / Q000502:physiology*; D008954:Models, Biological; D017711:Nonlinear Dynamics; D013045:Species Specificity
chemical_list: D056804:Biofuels