title: Assessment of gastric motor function in childhood functional dyspepsia and obesity.
abstract: BACKGROUND
  The aim was to compare gastric emptying rate and nutrient tolerance during a satiety drinking test in children with functional dyspepsia (FD) and obesity and to study the relationship between daily caloric intake and the satiety drinking test.
  
  
  METHODS
  A total of 28 dyspeptic children (22 girls, mean age 12.5 ± 3.1 years) and 15 obese children (five girls, 13.3 ± 1.8 years) were studied. The patients underwent an octanoic acid gastric emptying breath test and a satiety drinking test. Prior to both tests, a dyspepsia questionnaire was filled out to calculate the mean calorie intake.
  
  
  RESULTS
  The most prevalent dyspeptic symptoms were early satiety (96.4%), postprandial fullness (89.2%), and epigastric pain (78.6%), followed by nausea (50%). All dyspeptic and obese children (n = 43) started the satiety drinking test and 41 children completed the test until a score of 5 was reached. The maximum ingested volume in FD was significantly lower than in obesity or in age-matched healthy controls (252 ± 85 vs 479 ± 199 and 359 ± 29 mL respectively, both P < 0.05). As a group, dyspeptic children had significantly slower gastric emptying than obese children (89.7 ± 54.8 min vs 72.5 ± 26.0 min, P = 0.05). Daily calorie intake was significantly higher in obese children than that in dyspeptic children (2325 ± 469 vs 1503 ± 272 cal, P < 0.0001). The endpoint of the satiety drinking test was significantly correlated with body weight or BMI (both R = 0.41, P = 0.04), but not with daily calorie intake, gastric emptying rate or age.
  
  
  CONCLUSIONS
  The satiety drinking test is a potentially useful non-invasive tool in the investigation of children with FD and obesity.
authors: Department of Paediatric Gastroenterology, University Hospitals Leuven, Leuven, Belgium. ilse.hoffman@uzleuven.be
authors: I
authors: I
authors: Hoffman
authors: J
authors: J
authors: Tack
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001944:Breath Tests; D002648:Child; D004415:Dyspepsia / Q000503:physiopathology*; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D019518:Postprandial Period; D012528:Satiety Response / Q000502:physiology; D013270:Stomach / Q000503:physiopathology*