title: Synthesis of a dual-labeled probe of dimethyl lithospermate B with photochemical and fluorescent properties.
abstract: Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.
authors: Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors: Eunyoung
authors: E
authors: Lim
authors: Jeremy
authors: J
authors: Ricci
authors: Mankil
authors: M
authors: Jung
mesh_terms: D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry; D015335:Molecular Probes / Q000138:chemical synthesis*; D019920:Photoaffinity Labels / Q000378:metabolism*; D055668:Photochemical Processes; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
chemical_list: D004365:Drugs, Chinese Herbal; D015335:Molecular Probes; D019920:Photoaffinity Labels; C509610:dimethyl lithospermate B