title: Intratesticular benign peripheral nerve sheath tumour in a ferret (Mustela putorius furo).
abstract: A domestic ferret was submitted for sterilisation because of right testis enlargement. Oestradiol and cortisol concentrations were within normal physiological ranges, but testosterone was below and progesterone above normal. Microscopically, the right testis, with the exception of a small part of the epididymis, was replaced with neoplastic tissue. The tumour was composed of streams and bundles of closely packed spindle to ovoid cells forming whorls around collagen and capillaries, and separated by a collagenous matrix. In some areas, cells were loosely arranged and separated by a pale myxomatous matrix. The left testis showed atrophy. The majority of neoplastic cells expressed vimentin and S-100 protein, while expression of collagen IV was moderate and there was no expression of glial fibrillary acid protein. On the basis of macroscopical and histopathological findings, and supported by immunohistochemical reactivity, the diagnosis of benign peripheral nerve sheath tumour was made. This is the first report of benign peripheral nerve sheath tumour in ferret testis.
authors: Department of Veterinary Pathology, Orthopaedics and Ophthalmology Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia Zagreb Zoo, Zagreb, Croatia.
authors: M
authors: M
authors: Hohšteter
authors: O
authors: O
authors: Smolec
authors: A
authors: A
authors: Gudan Kurilj
authors: I-C
authors: IC
authors: Šoštarić-Zuckermann
authors: I
authors: I
authors: Bata
authors: Ž
authors: Ž
authors: Grabarevi
mesh_terms: D000818:Animals; D005289:Ferrets; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*