title: Application of RIFLE criteria in Chinese patients with ANCA-associated renal vasculitis.
abstract: OBJECTIVE
  Antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (AASV) constitutes a group of life-threatening diseases and renal involvement is its most severe and common manifestation. Acute kidney injury (AKI) is common in patients with AASV but the value of RIFLE criteria is still unclear in those patients.
  
  
  METHODS
  We performed a retrospective study on patients with AASV in Shanghai Ruijin Hospital from 1997 to 2008.
  
  
  RESULTS
  A total of 147 ANCA-associated renal vasculitis patients were studied and 92 developed AKI at diagnosis. According to RIFLE classification, 8 (8/147, 5.44%) patients had AKI-R, 15 (15/147, 10.20%) had AKI-I and 69 (69/147, 46.94%) had AKI-F. Our results demonstrated that more hypertensive patients and higher BVAS were found in patients with AKI-F than those in other groups (p<0.01 and p<0.01, respectively). Survival rate was significantly lower among patients with advanced RIFLE categories during remission-induction therapy (p<0.05). Survival rate of 1 year and total survival rate were significantly lower among patients with advanced RIFLE categories (p<0.01, p=0.001, respectively). Cox regression analysis demonstrated that advanced RIFLE categories were associated with a worse prognosis of the patients (OR=1.706, 95%CI: 1.262-2.307, p<0.01). The area under the ROC curve for mortality was 0.718 (95% CI: 0.63-0.81, p<0.001).
  
  
  CONCLUSIONS
  The RILFE criteria is a valid measurement of both prognosis and progression in patients with AASV.
authors: Department of Nephrology, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.
authors: Yong-Xi
authors: YX
authors: Chen
authors: Wen
authors: W
authors: Zhang
authors: Xiao-Nong
authors: XN
authors: Chen
authors: Ping-Yan
authors: PY
authors: Shen
authors: Hao
authors: H
authors: Shi
authors: Yao-Wen
authors: YW
authors: Xu
authors: Hong
authors: H
authors: Ren
authors: Nan
authors: N
authors: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D044466:Asian People; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate