title: Giant cell tumor of bone: are we stratifying results appropriately?
abstract: BACKGROUND
  There is no consensus as to which surgical approach to the treatment of giant cell tumor of bone is most appropriate or which patients are at a higher risk for recurrence or metastasis.
  
  
  OBJECTIVE
  Therefore, we asked: (1) Are there subsets of patients who are associated with a more recalcitrant disease course? And (2) are surgeons appropriately stratifying patients by identifying risk factors for increased local recurrence and pulmonary metastases?
  
  
  METHODS
  We retrospectively reviewed the records of 230 patients with giant cell tumor of bone treated from 1980 to 2010, stratifying them by primary versus recurrent disease and by surgical treatment. From the records, we determined local recurrence, metastatic disease, and complications of treatment. The median follow up was 47 months (range, 0.1-312 months).
  
  
  RESULTS
  Overall incidence of local recurrence was 10% and pulmonary metastasis was 2%. When stratified by surgical treatment, the incidence of local recurrence among patients undergoing intralesional curettage (12%) was greater than in those undergoing resection (2%). The incidence of local recurrence among primary tumors, independent of treatment, was 9%, whereas the incidence of local recurrence after treatment of recurrent lesions was 16%. The incidence of pulmonary metastases was similar, regardless of treatment or whether primary or recurrent.
  
  
  CONCLUSIONS
  Our observations suggest there are subsets of patients with giant cell tumor of bone who are at higher risk of recurrence and should be clinically followed more closely. This should allow surgeons to provide patients with more informed expectations.
  
  
  METHODS
  Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
authors: Department of Orthopaedic Surgery, University of California Los Angeles Medical Center, Box 956902, 76-143 CHS, Los Angeles, CA, USA. tjkremen@mednet.ucla.edu
authors: Thomas J
authors: TJ
authors: Kremen
authors: Nicholas M
authors: NM
authors: Bernthal
authors: Mark A
authors: MA
authors: Eckardt
authors: Jeffrey J
authors: JJ
authors: Eckardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D002648:Child; D003475:Curettage; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011884:Radius; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000556:secondary; D013977:Tibia; D055815:Young Adult