title: Primary brain T-cell lymphoma in an HTLV-1 serologically positive male.
abstract: Primary central nervous system lymphoma (PCNSL) is a subgroup of extranodal non-Hodgkin lymphoma usually due to B-cells. The incidence of T-cell PCNSL is 1-4% in Western countries. Human T-lymphotropic virus (HTLV-1) causes tropical spastic paraparesis/myelopathy and adult T-cell leukemia/lymphoma. We describe the extremely rare occurrence of T-cell PCNSL in a 29 year old HTLV-1 carrier. Additional unusual features of the case included the patient's young age and normal cerebrospinal fluid cytological findings, without leptomeningeal spread. Given the long latency between HTLV-1 infection and disease manifestation, more such cases may be diagnosed in the future. We recommend that every patient with T-cell PCNSL be screened for HTLV-1.
authors: Department of Neurology, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. itayl@clalit.org.il
authors: Itay
authors: I
authors: Lotan
authors: Alexander
authors: A
authors: Khlebtovsky
authors: Edna
authors: E
authors: Inbar
authors: Julia
authors: J
authors: Strenov
authors: Ruth
authors: R
authors: Djaldetti
authors: Israel
authors: I
authors: Steiner
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001706:Biopsy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000523:psychology; D003131:Combined Modality Therapy; D004569:Electroencephalography; D017809:Fatal Outcome; D015490:HTLV-I Infections / Q000473:pathology* / Q000523:psychology / Q000628:therapy; D015368:Human T-lymphotropic virus 1; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000523:psychology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000209:etiology / Q000523:psychology; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate