title: The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.
abstract: A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abundance in the nervous system is dependent on food intake, showing environmental modulation of pathway signaling. DAF-2 abundance is not dependent on downstream PI-3 kinase to DAF-16 transcription factor signaling. The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest.
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors: K D
authors: KD
authors: Kimura
authors: D L
authors: DL
authors: Riddle
authors: G
authors: G
authors: Ruvkun
mesh_terms: D000483:Alleles; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D004777:Environment; D009154:Mutation / Q000235:genetics; D009420:Nervous System / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D021381:Protein Transport; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin