title: Conference Scene: chromatin, replication and chromosomal stability.
abstract: The Chromatin, Replication and Chromosomal Stability Conference took place on June 20-21 in Stockholm, Sweden. In this article, I outline the broad scientific program of the meeting which reflected the wide diversity in epigenetics research. Distinct histone modifications are linked with specific chromatin structures and intranuclear positioning, thereby impacting replication timing and replication initiation, which in turn are related to gene expression and cell differentiation. Interference in any of these interconnected mechanisms can result in DNA breakage and lead to the activation of repair pathways. The DNA repair mechanisms again are influenced by the chromatin structure. In summary, the conference highlighted the functional implication of epigenetics in chromatin compaction, transcription regulation, replication control and DNA repair. The tight control of all these mechanisms defines the final cellular character.
authors: Department of Functional Genomics & Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, BP 10142-67404 ILLKIRCH Cedex, France. anneh@igbmc.fr
authors: Anne
authors: A
authors: Helmrich
mesh_terms: D002843:Chromatin / Q000502:physiology*; D043171:Chromosomal Instability; D003226:Congresses as Topic; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D042522:DNA Replication Timing / Q000502:physiology*; D057890:Epigenomics / Q000379:methods* / Q000639:trends
chemical_list: D002843:Chromatin