title: The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
abstract: Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of cancer-induced immunosuppression. Differentiating dendritic cells (DCs) exposed to tumor-derived factors may be arrested at an immature stage becoming inept at initiating immune responses and may induce effector T-cell anergy or deletion. These tolerogenic DCs, which accumulate in patients with different types of cancers, are also involved in the generation of Treg. In turn, Treg that expand during tumor progression contribute to the immune tolerance of cancer by impeding DCs' ability to orchestrate immune responses and by directly inhibiting antitumoral T lymphocytes. Herein we review these bidirectional communications between DCs and Treg as they relate to the promotion of cancer-induced tolerance.
authors: Faculty of Medicine, INSERM UMR 866, IFR 100, 21000 Dijon, France.
authors: Nona
authors: N
authors: Janikashvili
authors: Bernard
authors: B
authors: Bonnotte
authors: Emmanuel
authors: E
authors: Katsanis
authors: Nicolas
authors: N
authors: Larmonier
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation; D002478:Cells, Cultured; D017635:Clonal Anergy; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D009369:Neoplasms; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019139:Tumor Escape
chemical_list: D000951:Antigens, Neoplasm