title: Quercetin alleviates bisphenol A-induced changes in nucleic acid and protein contents in mice.
abstract: The present study was an attempt to examine toxic effects of bisphenol A in liver and kidney of mice and its alleviation by quercetin. Oral administration of bisphenol A (60 and 120 mg/kg b. w./day) for 30 days caused, as compared to vehicle control significant, dose-dependent decrease in DNA, RNA and protein contents in liver and kidney of mice. Supplementation of quercetin (60 mg/kg b. w./day) along with bisphenol A for 30 days caused, as compared to bisphenol A alone treated groups, significant alleviation in DNA, RNA and protein contents. The amelioration was comparatively higher for high dose bisphenol A plus quercetin treated group than that of low dose plus quercetin treated group.
authors: Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, Gujarat, India.
authors: Neha P
authors: NP
authors: Sangai
authors: J Ramtej
authors: JR
authors: Verma
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001559:Benzhydryl Compounds; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism*; D013997:Time Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004247:DNA; D010636:Phenols; D020011:Protective Agents; D011506:Proteins; D011794:Quercetin; D012313:RNA; C006780:bisphenol A; D000098826:Bisphenol A Compounds