title: Comparison of an intraoperative infusion of dexmedetomidine or remifentanil on perioperative haemodynamics, hypnosis and sedation, and postoperative pain control.
abstract: This prospective, randomized, double-blind study compared the effects of dexmedetomidine and remifentanil on haemodynamic stability, sedation and postoperative pain control in the postanaesthetic care unit (PACU). Fifty consecutive patients scheduled for total laparoscopic hysterectomy  were randomly assigned to receive infusions of either dexmedetomidine (1 μg/kg) i.v. over 10 min followed by 0.2 - 0.7 μg/kg per h continuous i.v. infusion or remifentanil (0.8 - 1.2 μg/kg) i.v. over 1 min followed by 0.05 - 0.1 μg/kg i.v. per min, starting at  the end of surgery to the time in the PACU. Modified observer's assessment of alertness scores were significantly lower in the dexmedetomidine group than in the remifentanil group at 0, 5 and 10 min after arrival in the PACU. Blood pressure and heart rate in the dexmedetomidine group were  significantly lower than that recorded in the remifentanil group in the PACU. Dexmedetomidine, at the doses used in this study, had a significant advantage over remifentanil in terms of postoperative haemodynamic stability.
authors: Department of Anaesthesiology and Pain Medicine, St Vincent's Hospital, The Catholic University of Korea, Suwon, Republic of Korea.
authors: H S
authors: HS
authors: Jung
authors: J D
authors: JD
authors: Joo
authors: Y S
authors: YS
authors: Jeon
authors: J A
authors: JA
authors: Lee
authors: D W
authors: DW
authors: Kim
authors: J H
authors: JH
authors: In
authors: H Y
authors: HY
authors: Rhee
authors: J W
authors: JW
authors: Choi
mesh_terms: D000328:Adult; D001794:Blood Pressure; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007044:Hysterectomy; D007432:Intraoperative Period; D010535:Laparoscopy; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control*; D059035:Perioperative Period; D010865:Pilot Projects; D010880:Piperidines / Q000008:administration & dosage*; D000077208:Remifentanil
chemical_list: D006993:Hypnotics and Sedatives; D010880:Piperidines; D020927:Dexmedetomidine; D000077208:Remifentanil