title: [Short-term central nervous system symptoms and changes in blood indicators after benzene poisoning in rats].
abstract: OBJECTIVE
  To observe the central nervous system symptoms and alterations in the blood indicators in rats within a short term after benzene poisoning.
  
  
  METHODS
  Twenty-four female SD rats were randomized into 4 equal groups to receive intraperitoneal injection of low-, medium- or high-dose benzene (39.05, 78.11, and 234.33 mg/kg, respectively) or peanut oil. Blood samples were taken from the rats via the femoral artery 24 h after the injections for routine blood test and liver and kidney function test.
  
  
  RESULTS
  Intraperitoneal injection of benzene at a high dose, but not at a low or medium dose, caused obvious symptoms in the central nervous system. Benzene either at a low or medium dose did not produce obvious changes in routine blood test or liver and kidney function test as compared with the control group, but a high dose resulted in significant changes in WBC, PLT, ALT and AST (P<0.05). Abnormalities in the renal function were found in none of the groups (P>0.05).
  
  
  CONCLUSIONS
  Exposure to high-dose benzene can result in abnormalities in the central nervous system, routine blood indicators and liver function, but does not obviously affect the kidney function in rats.
authors: Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300, China. qiuyingliu@yahoo.com.cn
authors: Qiu-ying
authors: QY
authors: Liu
authors: Xiao-yang
authors: XY
authors: Liang
authors: Xiu-qin
authors: XQ
authors: Wang
authors: Nian-guang
authors: NG
authors: Chen
authors: Jie
authors: J
authors: Sun
authors: Guan-chao
authors: GC
authors: Lai
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001554:Benzene / Q000633:toxicity*; D001772:Blood Cell Count; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001554:Benzene