title: The efficacy of three transection techniques of the liver resection: a randomized clinical trial.
abstract: OBJECTIVE
  Liver resection is a demanding procedure due to the risk of massive blood loss. Different instruments for liver transection are available today. The aim of this randomized clinical trial was to analyze the efficacy of three different parenchyma transection techniques of liver resection.
  
  
  METHODS
  A total of 60 non-cirrhotic patients undergoing hepatectomy were randomly selected for clamp crushing technique (CRUSH), ultrasonic dissection (CUSA) or bipolar device (LigaSure), n=20 in each group. All patients had liver resection under low central venous pressure anaesthesia (CVP), with ischemic preconditioning and intermittent inflow occlusion. Primary endpoints were surgery duration, transection duration, cumulative pedicle clamping time, intraoperative blood loss and blood transfusion. Secondary endpoints included the postoperative liver injury, postoperative morbidity and mortality.
  
  
  RESULTS
  Overall surgery duration was 295 vs. 270 vs. 240min for LigaSure, CUSA and Clamp Crushing Technique, respectively. The transection duration was 85 vs. 52.5 vs. 40 minutes, respectively. These three different resection techniques of non-cirrhotic liver produced similar outcome in terms of intraoperative blood loss, blood transfusion, postoperative complications and mortality.
  
  
  CONCLUSIONS
  The Clump Crushing Technique, CUSA and Liga Sure are equally safe for resection of non-cirrhotic liver. Liver resections can be performed safely if the entire concept is well designed and the choice of dissection device does not affect the outcome of hepatectomy.
authors: Clinical Center of Serbia, Belgrade, Serbia.
authors: Krstina
authors: K
authors: Doklestic
authors: Aleksandar
authors: A
authors: Karamarkovic
authors: Branislav
authors: B
authors: Stefanovic
authors: Branislava
authors: B
authors: Stefanovic
authors: Nataša
authors: N
authors: Milic
authors: Pavle
authors: P
authors: Gregoric
authors: Vladimir
authors: V
authors: Djukic
authors: Djordje
authors: D
authors: Bajec
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D001810:Blood Volume; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D019934:International Normalized Ratio; D007511:Ischemia / Q000209:etiology* / Q000517:prevention & control; D019194:Ischemic Preconditioning; D016014:Linear Models; D008099:Liver / Q000098:blood supply* / Q000293:injuries; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin