title: Genotypes of Candida albicans involved in development of candidiasis and their distribution in oral cavity of non-candidiasis individuals.
abstract: Genotype characteristics and distribution of commensal Candida albicans should be studied to predict the development of candidiasis, however, extensive genotype analysis of commensal C. albicans has not been made. In this study, 508 C. albicans isolates were collected from patients with/without candidiasis and divided into 4 isolate groups (SG-1, oral cavity of non-candidiasis patients; SG-2, patients with cutaneous candidiasis; SG-3, patients with vaginal candidiasis; SG-4, patients with candidemia). These isolates were characterized to study the relationship between genotypes and pathogenicity using microsatellite analysis. Using CDC3 and CAI, 5 genotypes (I, 111: 115/33: 41; II, 115: 119/23: 23; III, 115: 123/18: 27; IV, 115: 123/33: 40; and V, 123: 127/32: 41) were found in 4.2%, 8.9%, 7.1%, 2.2% and 3.1% of the isolates, respectively. Genotypes II and III were commonly found in all isolate groups. These genotypes were further divided into 28 types by additional HIS3 and CAIII microsatellite markers. In this analysis, C. albicans with type 6 and type 23 was widely distributed as a commensal species in the oral cavity of non-candidiasis patients and found to be related with candidiasis development. Additionally, genotypes I and IV were found in SG-2 and/or SG-4, suggesting that the fungus with those genotypes is also involved in this development. In contrast, genotype V was not identified in any infective isolates.
authors: Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry.
authors: Yuki
authors: Y
authors: Takagi
authors: Hisao
authors: H
authors: Hattori
authors: Hidesada
authors: H
authors: Adachi
authors: Shunji
authors: S
authors: Takakura
authors: Toshinobu
authors: T
authors: Horii
authors: Ariya
authors: A
authors: Chindamporn
authors: Hiroki
authors: H
authors: Kitai
authors: Reiko
authors: R
authors: Tanaka
authors: Takashi
authors: T
authors: Yaguchi
authors: Hideo
authors: H
authors: Fukano
authors: Fumihiko
authors: F
authors: Kawamoto
authors: Kazuo
authors: K
authors: Shimozato
authors: Toshio
authors: T
authors: Kanbe
mesh_terms: D002176:Candida albicans / Q000235:genetics* / Q000302:isolation & purification*; D002177:Candidiasis / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D009055:Mouth / Q000382:microbiology*