title: HIV-associated PML: changing epidemiology and clinical approach.
abstract: Despite the availability of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) infection, there has not been a dramatic decrease in the frequency of progressive multifocal leukoencephalopathy (PML) in the HIV-infected population. Usually a multifocal progressive disease of nonenhancing lesions in white matter, PML can have distinct characteristics in HIV-infected patients, including unifocal static lesions of faint contrast enhancement on imaging and involvement of gray matter. A syndrome of cerebellar degeneration has been described in association with HIV infection in patients positive for JC virus, the papovavirus responsible for PML. The standard of care for HIV-associated PML is HAART to achieve immunologic recovery and optimal HIV virologic control. The prognosis of PML has improved greatly since the advent of HAART.
authors: Neuro-AIDS Research Program, Clinical Neurophysiology Laboratories, Mount Sinai Medical Center, New York, NY, USA. david.simpson@mssm.edu
authors: David M
authors: DM
authors: Simpson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000821:virology; D023241:Antiretroviral Therapy, Highly Active; D006801:Humans; D015994:Incidence; D007577:JC Virus; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000821:virology