title: In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
abstract: AIC246 (letermovir) is a potent anticytomegalovirus drug in clinical development. Here, we report a consistent antiviral efficacy of AIC246 against human cytomegalovirus laboratory strains, clinical isolates, and virus variants resistant to approved drugs. Furthermore, we describe a remarkable selectivity of AIC246 for human cytomegaloviruses compared to that of other alpha-, beta-, or gammaherpesviruses or nonrelated pathogenic viruses, including adeno-, hepadna-, retro-, orthomyxo-, and flaviviruses. Our data confirm and support an excellent and selective anticytomegaloviral activity of AIC246.
authors: AiCuris GmbH & Co. KG, Wuppertal, Germany.
authors: Manfred
authors: M
authors: Marschall
authors: Thomas
authors: T
authors: Stamminger
authors: Andreas
authors: A
authors: Urban
authors: Steffen
authors: S
authors: Wildum
authors: Helga
authors: H
authors: Ruebsamen-Schaeff
authors: Holger
authors: H
authors: Zimmermann
authors: Peter
authors: P
authors: Lischka
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000821:virology*; D024882:Drug Resistance, Viral / Q000187:drug effects; D006564:Herpesviridae / Q000145:classification / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D014777:Virus Diseases / Q000821:virology; D014780:Viruses / Q000145:classification / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011799:Quinazolines