title: Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells.
abstract: BACKGROUND
  Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease.
  
  
  METHODS
  KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells.
  
  
  RESULTS
  Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures.
  
  
  CONCLUSIONS
  These findings suggest that photothermal treatment of oral squamous cell carcinoma has considerable advantages.
authors: Dental Department, AJA University of Medical Sciences, Laser Research Center, Dental Faculty, Tehran University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Fekrazad
authors: Neda
authors: N
authors: Hakimiha
authors: Enice
authors: E
authors: Farokhi
authors: Mohammad Javad
authors: MJ
authors: Rasaee
authors: Mehdi Shafiee
authors: MS
authors: Ardestani
authors: Katayoun A M
authors: KA
authors: Kalhori
authors: Farzaneh
authors: F
authors: Sheikholeslami
mesh_terms: D000906:Antibodies / Q000008:administration & dosage* / Q000737:chemistry; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000628:therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000008:administration & dosage* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007624:KB Cells; D009062:Mouth Neoplasms / Q000378:metabolism / Q000628:therapy*; D057145:Nanoshells / Q000008:administration & dosage* / Q000737:chemistry; D010789:Phototherapy / Q000379:methods; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000906:Antibodies; D006046:Gold; D018719:Erb-b2 Receptor Tyrosine Kinases; D012822:Silicon Dioxide