title: Is hyperandrogenemia protective for fibrocystic breast disease in PCOS?
abstract: The aim of this study is to evaluate the fibrocystic breast disease rates and its association with different clinical, endocrine and metabolic parameters between main polycystic ovary syndrome (PCOS) phenotypes. One hundred thirty two consecutive women were included in the study. Body mass index, serum follicle-stimulating hormone, luteinizing hormone (LH), progesterone, estradiol, testosterone, dehydroepiandrosterone sulphate, fasting glucose, low density lipoprotein (LDL-C), total cholesterol, high density lipoprotein, insulin, insulin sensitivity and fibrocystic breast disease rates were compared among different phenotypes of PCOS. Group 1: Polycystic ovaries (PCO)-anovulation (n = 32), Group 2: Hyperandrogenemia (HA)-anovulation (n = 28), Group 3: HA-PCO (n = 29), Group 4: HA-PCO-anovulation (n = 43). There were statistically significant differences between the different phenotype groups in terms of waist-hip ratio (p = 0.006), serum LDL-C (p = 0.008), LH (p = 0.002), estradiol (p = 0.022), fasting glucose (p = 0.001), progesterone (p = 0.007), free testosterone levels (p < 0.001) and Ferriman-Gallwey (FG) scores (p < 0.001). Different phenotype groups had significantly different fibrocystic breast disease rates. (p = 0.016). Higher free testosterone >3 pg/dl was protective for fibrocystic disease (RR = 0.316, 95:% CI 0.109-0.912, p = 0.033). Higher FG scores were more protective for fibrocystic disease (RR = 0.005, 95:% CI 0.001-0.042, p < 0.001). Group 3 ovulatory PCOS patients with PCO and hyperandrogenemia phenotype had lower risk to develop fibrocystic disease, while higher rates were observed in group 1 anovulatory-normoandrogenemic PCOS patients. Hyperandrogenemia is protective for fibrocystic diseases in PCOS.
authors: Department of Obstetrics and Gynecology, Dr. Sami Ulus Women's Health Teaching and Research Hospital, Ankara, Turkey. enozkaya1979@gmail.com
authors: Enis
authors: E
authors: Ozkaya
authors: Evrim
authors: E
authors: Cakir
authors: Mehmet
authors: M
authors: Cinar
authors: Fadil
authors: F
authors: Kara
authors: Eralp
authors: E
authors: Baser
authors: Caner
authors: C
authors: Cakir
authors: Tuncay
authors: T
authors: Kucukozkan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005348:Fibrocystic Breast Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D011374:Progesterone / Q000097:blood; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol