title: Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array.
abstract: Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.
authors: Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland. ivo.kwee@irb.unisi.ch
authors: Ivo
authors: I
authors: Kwee
authors: Andrea
authors: A
authors: Rinaldi
authors: Paola
authors: P
authors: Rancoita
authors: Davide
authors: D
authors: Rossi
authors: Daniela
authors: D
authors: Capello
authors: Francesco
authors: F
authors: Forconi
authors: Nicola
authors: N
authors: Giuliani
authors: Roberto
authors: R
authors: Piva
authors: Giorgio
authors: G
authors: Inghirami
authors: Gianluca
authors: G
authors: Gaidano
authors: Emanuele
authors: E
authors: Zucca
authors: Francesco
authors: F
authors: Bertoni
mesh_terms: D018899:CpG Islands; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000235:genetics; D018628:Gene Dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000601:surgery; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011184:Postoperative Period
chemical_list: D004273:DNA, Neoplasm