title: Genetic analysis of hantaviruses and their rodent hosts in central-south China.
abstract: Hantaan virus (HTNV) and Seoul virus (SEOV) are two major zoonotic pathogens of hemorrhagic fever with renal syndrome (HFRS) in Asia. Hubei province, which is located in the central-south China, had been one of the most severe epidemic areas of HFRS. To investigate phylogenetic relationships, genetic diversity and geographic distribution of HTNV and SEOV in their reservoir hosts, a total of 687 rodents were trapped in this area between 2000 and 2009. Sequences of partial S- and M-segments of hantaviruses and mitochondrial D-loop gene from 30 positive samples were determined. Our data indicated that SEOV and HTNV were co-circulating in Hubei. Phylogenetic analysis based on partial S- and M-segment sequences revealed two and three previously undefined lineages of SEOV, and a novel genetic lineage of HTNV, respectively. Four inter-lineage reassortment SEOVs carried by Rattus norvegicus and Apodemus agrarius were observed. It suggests that SEOV may cause spillover infections to A. agrarius naturally. The abundance of the phylogenetic lineages of SEOV suggested that central-south China was a radiation center for SEOVs.
authors: State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan 430071, PR China.
authors: Jing
authors: J
authors: Liu
authors: Dong-Ying
authors: DY
authors: Liu
authors: Wen
authors: W
authors: Chen
authors: Jin-Lin
authors: JL
authors: Li
authors: Fan
authors: F
authors: Luo
authors: Qing
authors: Q
authors: Li
authors: Jia-Xin
authors: JX
authors: Ling
authors: Yuan-Yuan
authors: YY
authors: Liu
authors: Hai-Rong
authors: HR
authors: Xiong
authors: Xiao-Hua
authors: XH
authors: Ding
authors: Wei
authors: W
authors: Hou
authors: Yun
authors: Y
authors: Zhang
authors: Shi-Yue
authors: SY
authors: Li
authors: Jie
authors: J
authors: Wang
authors: Zhan-Qiu
authors: ZQ
authors: Yang
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D004197:Disease Reservoirs; D005838:Genotype; D018063:Hantaan virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D058974:Phylogeography; D012367:RNA, Viral / Q000235:genetics; D012377:Rodentia / Q000821:virology*; D029263:Seoul virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins