title: Clinically palpable breast abnormalities with normal imaging: is clinically guided biopsy still required?
abstract: OBJECTIVE
  To determine the need for a fine-needle or core biopsy in patients with clinically palpable breast abnormalities who have negative mammographic and sonographic findings.
  
  
  METHODS
  Over a 12-year period, 251 patients with a palpable abnormality at presentation and who had a negative ultrasound and mammogram underwent clinically guided biopsy (CGB) by breast surgeons. This was 2.7% (251/9313) of all breast biopsies performed from January 1999 to December 2010. Physical findings were qualitatively categorized into five groups as clinically "normal", "benign", "probably benign", "suspicious", and "malignant" at the time of initial assessment. The number of biopsies for each category and biopsy results were analysed retrospectively.
  
  
  RESULTS
  Three (1.2%) of the 251 CGBs were reported as malignant; two (0.8%) of which were invasive. Forty-six (18.3%) of the 251 cases were regarded as clinically suspicious or malignant while the remaining 215 examinations were categorized as benign or probably benign. All three malignancies were in the clinically suspicious or malignant group.
  
  
  CONCLUSIONS
  A negative ultrasound and mammogram in patients with a palpable abnormality does not exclude breast cancer; however, the likelihood is very low (1.2%). In this study, 81.7% of biopsies (205/251) could have been avoided if CGB was reserved for the clinically suspicious or malignant group only without missing any malignancies.
authors: Department of Radiology, Dicle University, Medical School, Diyarbakır, Turkey. drhaticegumus@hotmail.com
authors: H
authors: H
authors: Gumus
authors: M
authors: M
authors: Gumus
authors: P
authors: P
authors: Mills
authors: D
authors: D
authors: Fish
authors: H
authors: H
authors: Devalia
authors: S E
authors: SE
authors: Jones
authors: P A
authors: PA
authors: Jones
authors: Ali R
authors: AR
authors: Sever
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000706:statistics & numerical data*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D010173:Palpation; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary; D055815:Young Adult