title: Methylphenidate transdermal system: clinical applications for attention-deficit/hyperactivity disorder.
abstract: The methylphenidate transdermal system (MTS) provides a novel method of delivery for methylphenidate, a well-studied and effective medication for attention-deficit/hyperactivity disorder. The MTS achieves two major goals. First, the delivery system allows for administration throughout the day with a single patch, thus improving adherence. Second, it is the first approved attention-deficit/hyperactivity disorder medication that is not administered orally, thus bypassing gastrointestinal absorption and first-pass metabolism through the enteric circulation. In this article, we review the current data on MTS, including preclinical, clinical and post-marketing studies, and compare efficacy and tolerability to currently available treatments.
authors: The Children's Hospital of Philadelphia, Science Center 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA. elia@email.chop.edu
authors: Josephine
authors: J
authors: Elia
authors: Zoe
authors: Z
authors: Wilson
authors: Lilly Sehgal
authors: LS
authors: La Porta
authors: Sibel A
authors: SA
authors: Algon
authors: Matthew L
authors: ML
authors: Prowler
authors: Shanique T
authors: ST
authors: Cartwright
authors: Patricia A
authors: PA
authors: McKenna
authors: Seth
authors: S
authors: Laracy
authors: Toshinobu
authors: T
authors: Takeda
authors: Karin
authors: K
authors: Borgmann-Winter
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000378:metabolism; D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage* / Q000378:metabolism*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate