title: MSLT in primary insomnia: stability and relation to nocturnal sleep.
abstract: OBJECTIVE
  To assess the stability of the multiple sleep latency test (MSLT) in primary insomnia and its relation to total sleep time.
  
  
  METHODS
  Randomized, double-blind, placebo controlled, clinical trial.
  
  
  METHODS
  Outpatient with sleep laboratory assessments in months 1 and 8 of treatment.
  
  
  METHODS
  Ninety-five primary insomniacs, 32-64 years old and 55 age- and sex-matched general population-based, representative controls.
  
  
  METHODS
  After a screening nocturnal polysomnograms (NPSG) and MSLT the following day, participants with primary insomnia were randomized to take zolpidem 10 mg (n = 50) or placebo (n = 45) nightly for 12 months. During months 1 and 8, while taking their prescribed treatments, NPSGs and MSLTs the following day were conducted. A population-based sample served as controls and received a single NPSG followed by MSLT.
  
  
  RESULTS
  Mean daily sleep latency on the screening MSLT of insomniacs was normally distributed across the full range of MSLT scores and significantly higher than those of a population-based representative control sample (P < 0.006). The insomniacs with the highest screening MSLTs had the shortest screening total sleep times (P < 0.05). The MSLTs of insomniacs during treatment in study month 1 were correlated (r = 0.44, P < 0.001) with their month 8 MSLT. The mean MSLT score of the zolpidem group did not differ from that of the placebo group, and the stability within treatment groups also did not differ.
  
  
  CONCLUSIONS
  These data support the hypothesis that some insomniacs show a reliable disorder of hyperarousal with increased wake drive both at night and during the day.
authors: Sleep Disorders & Research Center, Henry Ford Hospital, 2799 W. Grand Blvd., Detroit, Michigan 48202, USA. troehrs1@hfhs.org
authors: Timothy A
authors: TA
authors: Roehrs
authors: Surilla
authors: S
authors: Randall
authors: Erica
authors: E
authors: Harris
authors: Renee
authors: R
authors: Maan
authors: Thomas
authors: T
authors: Roth
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011725:Pyridines / Q000627:therapeutic use; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors; D000077334:Zolpidem
chemical_list: D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem