title: Coanalgesics for chronic pain therapy: a narrative review.
abstract: Chronic pain is inadequately treated in many patients, which has led clinicians and researchers to investigate new indications for existing medications with pain-relieving or adjuvant properties. These medications are known as coanalgesics. This review provides an evidence-based overview of select coanalgesics that are used in clinical practice for a variety of neuropathic and musculoskeletal pain disorders. The coanalgesics include antidepressants, anticonvulsants, topical agents, skeletal muscle relaxants, and antispasmodic agents. An update on emergent treatments and uses is also presented. The goals of this article are to highlight coanalgesic treatment options that are currently available for patients with chronic pain as well as provide guidelines for their use in clinical practice.
authors: Roudebush VA Medical Center of Excellence on Implementing Evidence-Based Practice, Indianapolis, IN 46202, USA. mbair@iupui.edu
authors: Matthew J
authors: MJ
authors: Bair
authors: Tamara R
authors: TR
authors: Sanderson
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy*; D006801:Humans; D009465:Neuromuscular Agents / Q000627:therapeutic use; D056687:Off-Label Use; D010276:Parasympatholytics / Q000627:therapeutic use; D026941:Sodium Channel Blockers / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D000927:Anticonvulsants; D000928:Antidepressive Agents; D009465:Neuromuscular Agents; D010276:Parasympatholytics; D026941:Sodium Channel Blockers