title: [Hypertension complicated with chronic kidney disease].
abstract: Hypertension causes exacerbation of chronic kidney disease (CKD) and vice versa. CKD has been known as an independent risk factor for death from cardiovascular disease (CVD). Proteinuria and albuminuria indicate progressive kidney injury and are risk factors for end-stage renal disease(ESRD). Corrections of blood pressure and proteinuria or albuminuria reduce the risk of occurrence of CVD and progression to ESRD. Antihypertensive therapy in CKD includes the management of salt sensitivity and renin angiotensin system. Diuretics more effectively contribute to the balance of sodium and volume of water, when used with ACE inhibitor and ARB. Direct renin inhibitor has been available and shown potential to be a first choice for the treatment of hypertension in CKD.
authors: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine.
authors: Kenji
authors: K
authors: Koizumi
authors: Sadayoshi
authors: S
authors: Ito
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D012084:Renin-Angiotensin System / Q000187:drug effects