title: The integral inventory for depression, a new, self-rated clinimetric instrument for the emotional and painful dimensions in major depressive disorder.
abstract: OBJECTIVE
  To assess the reliability and validity of the Integral Inventory for Depression (IID) scale using post hoc analyses of data from a multi-country study (ClinicalTrials.gov: NCT00561509) of patients with major depressive disorder (MDD).
  
  
  METHODS
  Patients (N = 1629) completed the IID (comprising two separate dimensions for emotional and physically painful symptoms; maximum score of 65) and a reference scale (16-item Quick Inventory of Depressive Symptomatology Self-Report) at baseline and at follow-up (8 and 24 weeks). Physicians rated MDD symptoms using the Clinical Global Impressions of Severity scale at each visit. Inter-item correlation, internal consistency, external validity, factor structure, and exploratory analysis of an optimal severity cut-off point were assessed.
  
  
  RESULTS
  The IID displayed two distinct dimensions (i.e. painful and emotional) with little item redundancy and good internal consistency (Cronbach's α > 0.83 at each visit). The IID displayed good external validity (Pearson's correlations coefficients >0.60 at each visit) and statistically significant agreement (McNemar's test; P < 0.001 at follow-up) with the reference scale. Results suggest that a cut-off score of ≤24 had adequate precision (>80%) to identify patients with and without moderate MDD.
  
  
  CONCLUSIONS
  Results suggest that the IID may be a reliable and valid tool for assessing emotional and painful symptoms of MDD.
authors: Eli Lilly de México, Col. San José Insurgentes, Mexico City, Mexico. duenas@lilly.com
authors: Héctor
authors: H
authors: Dueñas
authors: Carmen
authors: C
authors: Lara
authors: Richard J
authors: RJ
authors: Walton
authors: Renee E
authors: RE
authors: Granger
authors: Martin
authors: M
authors: Dossenbach
authors: Joel
authors: J
authors: Raskin
mesh_terms: D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D004644:Emotions / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D019370:Observation; D010146:Pain / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D011594:Psychometrics / Q000295:instrumentation*; D015203:Reproducibility of Results; D012720:Severity of Illness Index