title: Vitamin E supplementation modulates gingival crevicular fluid lipid peroxidation and antioxidant levels in patients with orthodontic tooth movement.
abstract: The aim of this study was to investigate the levels of the oxidant and antioxidant changes in orthodontic tooth movement and the effects of vitamin E on these parameters. For this purpose, 50 orthodontic patients (aged 13-18 years) required non-extracted treatment were divided randomly into the following groups: Control and Vitamin E. Same pre-adjusted appliances were applied to all patients, and vitamin E (300 mg day(-1)) was given during 1 month in vitamin E group. Gingival crevicular fluid was collected and periodontal indexes were recorded at the baseline and after 1 month. Lipid peroxidation (LP) levels as malonyldialdehyde, reduced glutathione (GSH) and glutathione peroxidase (GSH-Px), vitamin C and E levels were measured in the anterior and posterior regions of the dentition. After 1 month, orthodontic treatment LP levels increased in control group in both anterior and posterior regions in vitamin E group. LP levels also increased in vitamin E group in only posterior region. The level of GSH and vitamin C did not change statistically in control and vitamin E groups. Periodontal indexes did not show any differences in comparison with the groups. In conclusion, we observed protective role of vitamin E on LP levels in anterior region of patients with orthodontic tooth movement.
authors: Department of Orthodontics, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey. elcines@yahoo.com
authors: Elçin
authors: E
authors: Esenlik
authors: Mustafa
authors: M
authors: Naziroğlu
authors: Cahide
authors: C
authors: Açikalin
authors: Ishak Suat
authors: IS
authors: Övey
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005883:Gingival Crevicular Fluid / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D014087:Tooth Movement Techniques; D014810:Vitamin E / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005978:Glutathione; D001205:Ascorbic Acid