title: Acute adrenal failure associated with primary antiphospholipid syndrome and homozygosity for MTHFR C677T.
abstract: A 47-year-old woman with a recent clinical diagnosis of acute cholecystitis developed acute adrenal failure. Initial computed tomograms of the abdomen showed bilateral adrenal swelling which evolved into bilateral adrenal hemorrhage on repeat examination a few days later. Laboratory investigations revealed a previously undiagnosed primary antiphospholipid syndrome and homozygosity for the MTHFR C677T mutation with hyperhomocysteinemia. This case highlights the protean clinical manifestations of adrenal vascular accidents and the need for a thorough search for underlying prothrombotic states in this setting.
authors: The First Department of Internal Medicine, Amalia Fleming General Hospital, Greece.
authors: Anastasios
authors: A
authors: Mavridis
authors: Marina
authors: M
authors: Skopeliti
authors: Panagiota
authors: P
authors: Galani
authors: Sofia
authors: S
authors: Lafoyianni
authors: Constantinos
authors: C
authors: Christopoulos
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)