title: Chromobility: the rapid movement of chromosomes in interphase nuclei.
abstract: There are an increasing number of studies reporting the movement of gene loci and whole chromosomes to new compartments within interphase nuclei. Some of the movements can be rapid, with relocation of parts of the genome within less than 15 min over a number of microns. Some of these studies have also revealed that the activity of motor proteins such as actin and myosin are responsible for these long-range movements of chromatin. Within the nuclear biology field, there remains some controversy over the presence of an active nuclear acto-myosin motor in interphase nuclei. However, both actin and myosin isoforms are localized to the nucleus, and there is a requirement for rapid and directed movements of genes and whole chromosomes and evidence for the involvement of motor proteins in this relocation. The presence of nuclear motors for chromatin movement is thus an important and timely debate to have.
authors: Laboratory of Nuclear and Genomic Health, Centre of Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, London UB8 3PH, UK. Joanna.bridger@brunel.ac.uk
authors: Joanna M
authors: JM
authors: Bridger
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism*; D056426:Genetic Loci / Q000235:genetics; D006801:Humans; D007399:Interphase; D009068:Movement; D009218:Myosins / Q000378:metabolism
chemical_list: D000199:Actins; D009218:Myosins