title: Cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy parameter predicts cardiac and cerebrovascular events in type 2 diabetic patients without structural heart disease.
abstract: BACKGROUND
  Cardiac iodine-123 metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is an established method of assessment of cardiovascular sympathetic function. The aim of the present study was to investigate the long-term cardiovascular predictive value of cardiac (123)I-MIBG scintigraphy parameters in Japanese type 2 diabetic patients without structural heart disease.
  
  
  RESULTS
  Cardiac (123)I-MIBG scintigraphy in 108 patients with type 2 diabetes who did not have structural heart disease, was evaluated. The washout rate (WR) was considered enhanced if it was ≥40%. Accurate follow-up information for 4.6 years was obtained in 54 enhanced WR patients (27 male; mean age, 61 ± 11 years) and in 54 sex- and age-matched preserved WR patients (27 male; mean age, 61 ± 10 years). Major adverse cardiac and cerebrovascular events (MACCE) were investigated. During follow-up, 10 enhanced WR patients developed MACCE including cardiac death, coronary revascularization, stroke, and congestive heart failure, while MACCE occurred in only 3 male patients. The Kaplan-Meier curves indicated that enhanced WR patients had higher incidence of MACCE than those with preserved WR (P<0.05). Cox proportional hazards regression analysis showed that age and enhanced WR were independently associated with the incidence of MACCE (hazard ratio, 4.06; 95% confidence interval: 1.194-18.76, P = 0.0237).
  
  
  CONCLUSIONS
  Abnormal WR of cardiac (123)I-MIBG scintigraphy at baseline has long-term cardiovascular predictive value in Japanese patients with type 2 diabetes without structural heart disease.
authors: Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Japan. yufukuni@oita-u.ac.jp
authors: Kunio
authors: K
authors: Yufu
authors: Naohiko
authors: N
authors: Takahashi
authors: Norihiro
authors: N
authors: Okada
authors: Tetsuji
authors: T
authors: Shinohara
authors: Mikiko
authors: M
authors: Nakagawa
authors: Masahide
authors: M
authors: Hara
authors: Hironobu
authors: H
authors: Yoshimatsu
authors: Tetsunori
authors: T
authors: Saikawa
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000401:mortality; D006801:Humans; D007457:Iodine Radioisotopes; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000401:mortality; D009204:Myocardial Revascularization / Q000401:mortality; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011877:Radionuclide Imaging / Q000379:methods / Q000706:statistics & numerical data*; D012680:Sensitivity and Specificity; D020521:Stroke / Q000000981:diagnostic imaging* / Q000401:mortality
chemical_list: D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine