title: Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia.
abstract: OBJECTIVE
  To characterize the impact of Mannheimia haemolytica infection on feed intake and weight gain in feedlot heifers and to evaluate the clinical efficacy of isoflupredone acetate administered in combination with oxytetracycline.
  
  
  METHODS
  96 weanling heifers in a research feedlot facility.
  
  
  METHODS
  Bronchopneumonia was induced by intrabronchial infusion of M haemolytica. Control heifers underwent a sham procedure. Infected heifers were treated with oxytetracycline alone or in combination with isoflupredone acetate (OXY-ISO) or with nothing. Clinical variables were recorded daily for 7 days following disease induction, and feedlot performance indices were measured over a 12-week period.
  
  
  RESULTS
  Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers that received no treatment. Oxytetracycline treatment alone did not prevent reductions in feed intake and ADG during the first week after infection was induced, whereas OXY-ISO treatment did prevent these reductions. Treatment with OXY-ISO also resulted in faster clinical improvement. No significant differences were evident between the oxytetracycline and OXY-ISO groups with respect to dry-matter intake or ADG throughout the study period.
  
  
  CONCLUSIONS
  Isoflupredone acetate appeared to be a useful clinical adjunct to treatment with oxytetracycline in cattle with acute M haemolytica bronchopneumonia.
authors: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada. jhewson@uoguelph.ca
authors: Joanne
authors: J
authors: Hewson
authors: Laurent
authors: L
authors: Viel
authors: Jeff L
authors: JL
authors: Caswell
authors: Patricia E
authors: PE
authors: Shewen
authors: Jock G
authors: JG
authors: Buchanan-Smith
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001996:Bronchopneumonia / Q000382:microbiology / Q000662:veterinary*; D002417:Cattle; D003612:Dairying; D004359:Drug Therapy, Combination / Q000662:veterinary; D005247:Feeding Behavior; D005260:Female; D005477:Fluprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use*; D006854:Hydrocortisone / Q000097:blood; D016978:Mannheimia haemolytica / Q000187:drug effects*; D009864:Ontario; D010118:Oxytetracycline / Q000627:therapeutic use*; D012766:Pasteurellosis, Pneumonic / Q000188:drug therapy* / Q000382:microbiology; D011897:Random Allocation; D015430:Weight Gain
chemical_list: D000907:Antibodies, Bacterial; D005938:Glucocorticoids; C065592:isoflupredone acetate; D005477:Fluprednisolone; D006854:Hydrocortisone; D010118:Oxytetracycline