title: A lupane triterpenoid and other constituents of Salvia eremophila.
abstract: Phytochemical investigation of the aerial parts of Salvia eremophila led to the isolation of a lupane triterpenoid, 3β, 20-dihydroxylupane-28-oic acid (1), together with eight other compounds, comprising three diterpene, two triterpene, two flavonoids and a steroidal glucoside. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1, 2-4 and 8 were evaluated for their cytotoxicities against five human tumour cell lines. Compounds 1 and 3 hold a good potential for use in future studies due to their anti-cancer properties.
authors: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran. m_moridi@sbu.ac.ir
authors: Mahdi Moridi
authors: MM
authors: Farimani
authors: Firouz Matloubi
authors: FM
authors: Moghaddam
authors: Mohammad Ali
authors: MA
authors: Esmaeili
authors: Gholamreza
authors: G
authors: Amin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053978:Pentacyclic Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005419:Flavonoids; D013729:Terpenes; D014315:Triterpenes; C000590714:3beta,20-dihydroxylupane-28-oic acid; C480546:lupane; D053978:Pentacyclic Triterpenes