title: Antagonistic effects of cadmium on lead accumulation in pregnant and non-pregnant mice.
abstract: People are frequently exposed to combinations of contaminants but there is a paucity of data on the effects of mixed contaminants at low doses. This study investigated the influence of cadmium (Cd) on lead (Pb) accumulation in pregnant and non-pregnant mice following exposure to contaminated soil. Exposure to Pb from contaminated soils increased Pb accumulation in both pregnant and non-pregnant mice compared to unexposed control animals (pregnant and non-pregnant). Lead accumulation in the liver and kidneys of exposure pregnant mice (40 ± 15 mg Pb kg(-1)) was significantly higher (P<0.05) than concentrations detected in control pregnant mice (<1 mg Pb kg(-1)). The presence of Cd in contaminated soil had a major effect on the Pb and Fe accumulation in the kidneys and liver, respectively. This study shows that Pb uptake is mediated by the presence of Cd in the co-contaminated soil and demonstrates that further research is required to investigate the influence of co-contaminants on human exposure at sub-chronic concentrations.
authors: Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095, Australia. euan.smith@unisa.edu.au
authors: Euan
authors: E
authors: Smith
authors: Dorota
authors: D
authors: Gancarz
authors: Allan
authors: A
authors: Rofe
authors: Ivan M
authors: IM
authors: Kempson
authors: John
authors: J
authors: Weber
authors: Albert L
authors: AL
authors: Juhasz
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D007854:Lead / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy
chemical_list: D002104:Cadmium; D007854:Lead