title: Dynamics of Moraxella bovis infection and humoral immune response to bovine herpes virus type 1 during a natural outbreak of infectious bovine keratoconjunctivitis in beef calves.
abstract: Infectious bovine keratoconjunctivitis (IBK) is an acute disease caused by Moraxella bovis (Mb). Several factors may predispose animals to an IBK outbreak; one commonly observed is infection with bovine herpes virus type 1 (BHV-1). The aim of this study was to investigate the dynamics of BHV-1 virus infection and its relation with clinical cases of IBK in weaned calves from a beef herd with a high prevalence of lesions caused by Mb. Sampling was carried out in six stages and included conjunctival swabs for isolating Mb as well as blood samples for identifying antibodies specific for BHV-1. A score for IBK lesions after observing each eye was determined. The findings of this study showed a high prevalence of BHV-1 virus infection (100% of animals were infected at the end of the trial); 67% of animals were culture-positive for Mb, but low rates of clinical IBK (19% of calves affected) were detected at the end of the trial. These results suggest that infection with BHV-1 did not predispose these animals to IBK, and that Mb infection produced clinical and subclinical disease in the absence of BHV-1 co-infection.
authors: Departamento de Salud Publica Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza, C.P. S3080HOF, Provincia de Santa Fe, Argentina. virginiazbrun@yahoo.com.ar
authors: M V
authors: MV
authors: Zbrun
authors: G C
authors: GC
authors: Zielinski
authors: H C
authors: HC
authors: Piscitelli
authors: C
authors: C
authors: Descarga
authors: L A
authors: LA
authors: Urbani
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D004196:Disease Outbreaks / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D056724:Immunity, Humoral; D007639:Keratoconjunctivitis, Infectious / Q000150:complications / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D016955:Moraxella bovis; D045828:Moraxellaceae Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology
chemical_list: D000914:Antibodies, Viral