title: Acid-induced transient isotachophoretic stacking of basic drugs in co-electroosmotic flow capillary zone electrophoresis.
abstract: Online sample concentration or stacking of basic drugs by transient isotachophoresis with the injection of an acid in co-electroosmotic flow capillary zone electrophoresis was studied experimentally and with computer simulation. The acid stacking strategy afforded an order of magnitude improvement in concentration sensitivity for model tricyclic antidepressant and β blocker drugs.
authors: Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Australia. jquirino@utas.edu.au
authors: Joselito P
authors: JP
authors: Quirino
authors: Michael C
authors: MC
authors: Breadmore
mesh_terms: D000143:Acids / Q000737:chemistry; D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D000928:Antidepressive Agents / Q000032:analysis*; D003198:Computer Simulation; D053841:Electroosmosis / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*
chemical_list: D000143:Acids; D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents