title: Triterpenoid saponins from Ilex mamillata C.Y. Wu ex C.J. Tseng.
abstract: Two new triterpenoid saponins, ilemaminosides A and B (1 and 2) along with six known saponins (3-8) were isolated from 70% ethanolic extract of the leaves of Ilex mamillata C.Y. Wu ex C.J. Tseng. The new saponins were characterised as 3-O-α-L-arabinopyranosyl-ilexgenin B (1) and 3-O-β-D-glucopyranosyl-(1 → 3)-α-L-arabinopyranosyl-ilexgenin B (2). The structures of compounds 1 and 2 were elucidated on the basis of the chemical and spectroscopic methods, and the structures of known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The compounds showed inhibitory activities in anti-inflammatory assay in vitro with IC(50) values in the range 25.37-38.33 µg mL(-1).
authors: Key Laboratory of Modern Chinese Medicines, Ministry of Education, Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China.
authors: Che
authors: C
authors: Yan-Yun
authors: Zhang
authors: Z
authors: Liang
authors: Li
authors: L
authors: Ning
authors: Zeng
authors: Z
authors: Ke-Wu
authors: Tu
authors: T
authors: Peng-Fei
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D030017:Ilex / Q000737:chemistry; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012503:Saponins; D014315:Triterpenes; C000590673:ilemaminoside A; C000590674:ilemaminoside B; D009569:Nitric Oxide