title: Change in cardiovascular disease status in peritoneal dialysis patients: a 5-year single-center experience.
abstract: BACKGROUND
  We compared patient characteristics, atherosclerosis, left ventricular hypertrophy, and dialysis practice patterns of peritoneal dialysis (PD) patients with change in cardiovascular disease (CVD) status and no change in CVD status in Chinese PD center.
  
  
  METHODS
  This study included all patients who started on PD between 1 January 2003 and 30 June 2009 at the Renji Hospital, Shanghai Jiaotong University School of Medicine, China. They were followed up from the date of PD initiation until new-onset CVD.
  
  
  RESULTS
  The median follow-up time was 44.13 months. In patients with preexisting CVD, both high triglyceride (1.43 ± 0.89 mmol/L vs. 2.64 ± 1.58 mmol/L, p < 0.001) and the duration of dialysis (45.76 ± 13.28 months vs. 58.68 ± 13.74 months, p < 0.01) were independent predictors of CVD progression and the left atrial dimension, left ventricle septal thickness, left ventricle mass index (LVMI), and intima-media thickness (IMT) also had the difference. On the other hand, in patients without preexisting CVD, the dialysis adequacy and nutritional status are important during the follow-up. Serum albumin in CVD group was lower than in no CVD group (30.86 ± 4.77 g/L vs. 36.04 ± 6.40 g/L, p < 0.05). Creatinine clearance (CCr) and Kt/V in CVD group were lower than in no CVD group (CCr 57.24 ± 13.86 L/week vs. 71.06 ± 23.96 L/week, p < 0.05; Kt/V 1.82 ± 0.41 vs. 2.23 ± 0.57, p < 0.05).
  
  
  CONCLUSIONS
  In patients with preexisting CVD, it is important to address traditional risk factors such as LVMI, IMT, and lipid profile. In patients without preexisting CVD, we should pay more attention to the nutritional status and PD prescription in order to lower the morbidity of CVD in these PD patients.
authors: Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.
authors: Shan
authors: S
authors: Mou
authors: Qin
authors: Q
authors: Wang
authors: Wei
authors: W
authors: Fang
authors: Aiwu
authors: A
authors: Lin
authors: Beili
authors: B
authors: Shi
authors: Liou
authors: L
authors: Cao
authors: Wenyan
authors: W
authors: Zhou
authors: Jiaqi
authors: J
authors: Qian
authors: Zhaohui
authors: Z
authors: Ni
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors