title: Structure-activity relationships of N-phenyl-N'-benzothiazol-6-ylurea synthetic derivatives: cytokinin-like activity and adventitious rooting enhancement.
abstract: Some years ago we demonstrated the cytokinin-like activity of the synthetic N-phenyl-N'-benzothiazol-6-ylurea (PBU) and a relevant adventitious rooting adjuvant activity of symmetric urea derivatives devoid of any cytokinin- or auxin-like activity per se. Here we report the synthesis and the biological activity evaluation of nine symmetric or asymmetric ureas/thioureas, structurally related to PBU. None of them show cytokinin-like activity, while we demonstrate for the first time that PBU interacts with Arabidopsis cytokinin receptor CRE1/AHK4 in a heterologous bioassay system. Among the PBU derivatives, all the symmetric ureas/thioureas show an adventitious rooting adjuvant activity in various bioassays, confirming that this activity is strictly dependent on their chemical structure.
authors: Dipartimento di Biologia Evolutiva e Funzionale, Viale GP Usberti 11/A, 43124 Parma, Italy.
authors: Enrico
authors: E
authors: Rolli
authors: Matteo
authors: M
authors: Incerti
authors: Federica
authors: F
authors: Brunoni
authors: Paola
authors: P
authors: Vicini
authors: Ada
authors: A
authors: Ricci
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D052160:Benzothiazoles / Q000737:chemistry / Q000378:metabolism*; D003583:Cytokinins / Q000378:metabolism*; D018517:Plant Roots / Q000254:growth & development / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D029681:Arabidopsis Proteins; D052160:Benzothiazoles; D003583:Cytokinins; C572837:N-phenyl-N'-benzothiazol-6-ylurea; D011956:Receptors, Cell Surface; D011494:Protein Kinases; C421783:WOL protein, Arabidopsis