title: Frajunolides L-O, four new 8-Hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis.
abstract: Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
authors: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.|Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors: Chia-Ching
authors: 0000-0001-5642-4679
authors: CC
authors: Liaw
authors: National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors: Yao-Haur
authors: YH
authors: Kuo
authors: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors: Yun-Sheng
authors: YS
authors: Lin
authors: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors: Tsong-Long
authors: 0000-0002-5780-3977
authors: TL
authors: Hwang
authors: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
authors: Ya-Ching
authors: YC
authors: Shen
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010196:Pancreatic Elastase