title: [Immunoglobulin G4-associated to multiorganic lymphoproliferative disease].
abstract: We report a case of a woman with lymphoproliferative multiorganic immunoglobulin G4 (IgG4) related disease with extensive involvement showing dacryoadenitis, sialoadenitis, parotiditis, pancreatitis, pneumonitis, lymphadenopathy and immune thrombocytopenic purpura. Serum elevation of acute phase reactant, polyclonal hypergammaglobulinemia, positivity for antinuclear antibodies and rheumatoid factor was found. Hystologically plasma cell infiltration was demonstrated on glandular and lymphatic tissue and immunochemistry was positive for IgG4 in > 30%. Immunosuppressive treatment with steroids and azathioprine was given with an excellent clinical response, the marked radiologic evidence of improvement and the decrease in inflammatory makers that conducted to symptom remission are shown in the text.
authors: Departamento de Medicina Interna, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. maitebourlon@gmail.com
authors: María T
authors: MT
authors: Bourlon
authors: Mónica
authors: M
authors: Chapa
authors: Fredy
authors: F
authors: Chablé Montero
authors: Jorge
authors: J
authors: Hernández Calleros
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D012074:Remission Induction
chemical_list: D007074:Immunoglobulin G