title: Favorable outcome of chronic disseminated candidiasis in four pediatric patients with hematological malignancies.
abstract: Four children were diagnosed with chronic disseminated candidiasis (CDC) during treatment for hematological malignancies. All presented with persistent fever, not responsive to broad-spectrum antibiotics, abdominal distension and hepatosplenomegaly. Two children needed artificial ventilation because of respiratory insufficiency. The time between onset of neutropenic fever and diagnosis of CDC ranged from 20-49 days. Ultrasound and computed tomography failed to demonstrate CDC during the neutropenic phase. All children needed a liver or spleen biopsy to establish the diagnosis of CDC. Three of four patients continued chemotherapy during treatment for the fungal infection. All patients had a favorable outcome, both in terms of the invasive Candida infections, as well as their underlying malignancies.
authors: Department of Pediatric Hematology and Oncology, Harbor Hospital, Rotterdam, the Netherlands. a.donker@cukz.umcn.nl
authors: Albertine E
authors: AE
authors: Donker
authors: Annelies M C
authors: AM
authors: Mavinkurve-Groothuis
authors: Lya E
authors: LE
authors: van Die
authors: Paul E
authors: PE
authors: Verweij
authors: Peter M
authors: PM
authors: Hoogerbrugge
authors: Adilia
authors: A
authors: Warris
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D001706:Biopsy; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis* / Q000473:pathology; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000473:pathology; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents