title: Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.
abstract: Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, and HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.
authors: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. niklas.bjorkstrom@ki.se
authors: Niklas K
authors: NK
authors: Björkström
authors: Alexandra
authors: A
authors: Svensson
authors: Karl-Johan
authors: KJ
authors: Malmberg
authors: Kristina
authors: K
authors: Eriksson
authors: Hans-Gustaf
authors: HG
authors: Ljunggren
mesh_terms: D018959:CD57 Antigens / Q000378:metabolism; D015550:Cell Degranulation / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006558:Herpes Genitalis / Q000276:immunology* / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000378:metabolism; D010641:Phenotype; D054340:Receptors, KIR / Q000378:metabolism; D012008:Recurrence
chemical_list: D018959:CD57 Antigens; C527059:KLRC2 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D054340:Receptors, KIR