title: Ovalicin ameliorates compound 48/80-induced atopic dermatitis-related symptoms.
abstract: Ovalicin, a secondary metabolite produced by an entomopathogenic fungus Metarhizium anisopliae var. anisopliae, is currently used as an efficient biological control agent against various agricultural insect pests, but not so many biological activities have been investigated. To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. The results revealed that ovalicin significantly reduces scratching behavior in a concentration-dependent fashion. Moreover, the treatment inhibits the levels of the degranulation of mast cells by 65%, and levels of histamine release by 51% at a concentration of 10 µg/ml. Together, the present data strongly suggest that ovalicin elicits potential anti-atopic activities in mice.
authors: Mycoplus Co., Ltd., Anyang 431–080, Korea.
authors: Cheol-Sik
authors: CS
authors: Yoon
authors: Sung-Hee
authors: SH
authors: Nam
authors: Ji-Young
authors: JY
authors: Jeon
authors: Hei-Sam
authors: HS
authors: Lee
authors: Myeong-Lyeol
authors: ML
authors: Lee
authors: Hyeong-U
authors: HU
authors: Son
authors: Sang-Han
authors: SH
authors: Lee
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D004195:Disease Models, Animal; D006632:Histamine / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D018926:Anti-Allergic Agents; D012717:Sesquiterpenes; C002781:ovalicin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine