title: Novel effect of adenosine 5'-monophosphate on ameliorating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats.
abstract: The aim of the study was to investigate the effects of adenosine 5'-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food.
authors: Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. ardy@biochem.tohoku.ac.jp
authors: Ardiansyah
authors: Hitoshi
authors: H
authors: Shirakawa
authors: Takuya
authors: T
authors: Koseki
authors: Kazuyuki
authors: K
authors: Hiwatashi
authors: Saori
authors: S
authors: Takahasi
authors: Yoshinobu
authors: Y
authors: Akiyama
authors: Michio
authors: M
authors: Komai
mesh_terms: D000249:Adenosine Monophosphate / Q000008:administration & dosage*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet; D006943:Hyperglycemia / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D006973:Hypertension / Q000188:drug therapy*; D008099:Liver / Q000737:chemistry; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D012333:RNA, Messenger; D014280:Triglycerides; D009569:Nitric Oxide; D000249:Adenosine Monophosphate