title: Early pregnancy testosterone after ovarian stimulation and pregnancy outcome.
abstract: OBJECTIVE
  To examine early pregnancy (EP) testosterone (T) after ovarian stimulation and its effect on singleton pregnancy outcomes.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University-based tertiary care center.
  
  
  METHODS
  Subfertile women who conceived with or without fertility treatment.
  
  
  METHODS
  Ovarian stimulation for assisted reproduction, collection of serum total T levels in early pregnancy, and pregnancy follow-up.
  
  
  METHODS
  Rate of preterm delivery, low birth weight (LBW) (<2,500 g), and hypertensive disorders of pregnancy.
  
  
  RESULTS
  EP serum samples were measured from 266 singleton pregnancies. The mean T level among spontaneous conceptions was 74.90 ng/dL (SD 48.35 ng/dL); 103 ng/mL was the 90th percentile. Mean EP T was increased among patients who underwent ovarian stimulation compared with nonstimulated control subjects. In patients undergoing IVF, T levels in EP were linearly correlated with the number of oocytes retrieved. When pregnancy outcomes in women with normal T were compared with women with elevated T (>90th percentile), we did not see an increased risk for preterm delivery, hypertensive disorders of pregnancy, LBW infants, or cesarean delivery (odds ratio ratios 1.43, 0.38, 1.39, and 0.85, respectively).
  
  
  CONCLUSIONS
  Elevations in EP T are associated with ovarian stimulation but do not appear to be associated with adverse pregnancy outcome. Further investigation to determine the etiology of increased maternal and neonatal morbidity among subfertile women is warranted.
authors: Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA. sfisher@stanford.edu
authors: Stephanie L F
authors: SL
authors: Gustin
authors: Gourab
authors: G
authors: Mukherjee
authors: Valerie L
authors: VL
authors: Baker
authors: Lynn M
authors: LM
authors: Westphal
authors: Amin A
authors: AA
authors: Milki
authors: Ruth B
authors: RB
authors: Lathi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000453:epidemiology*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007247:Infertility, Female / Q000453:epidemiology / Q000628:therapy; D008297:Male; D009017:Morbidity; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D047928:Premature Birth / Q000097:blood / Q000453:epidemiology*; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood*
chemical_list: D015415:Biomarkers; D013739:Testosterone