title: Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.
abstract: Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.
authors: Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge St., Boston, MA 02114, USA.
authors: Sarit S
authors: SS
authors: Agasti
authors: Monty
authors: M
authors: Liong
authors: Carlos
authors: C
authors: Tassa
authors: Hyun Jung
authors: HJ
authors: Chung
authors: Stanley Y
authors: SY
authors: Shaw
authors: Hakho
authors: H
authors: Lee
authors: Ralph
authors: R
authors: Weissleder
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D000906:Antibodies / Q000032:analysis* / Q000737:chemistry; D015415:Biomarkers / Q000032:analysis; D002460:Cell Line; D003505:Cyclodextrins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000032:analysis* / Q000737:chemistry
chemical_list: D000906:Antibodies; D015415:Biomarkers; D003505:Cyclodextrins; D005456:Fluorescent Dyes; D000218:Adamantane