title: Lifestyle factors and endothelial function.
abstract: Atherosclerotic disease remains a major health problem around the world. The central role of endothelium and inflammation in all stages of the atherosclerotic process is advocated by significant data. Moreover, clinical evidence supports the prognostic potential of endothelial dysfunction for the development of ischemic events and for adverse outcome after acute coronary syndromes. Interestingly, suboptimal lifestyle choices are implicated in the development and deterioration of this endothelial dysfunction, a fact with significant impact, considering the contribution of endothelial dysfunction in atherosclerosis and its complications. Many epidemiological research studies, using a variety of strategies, provide encouraging evidence suggesting that lifestyle modifications may have significant impact regarding the improvement of endothelial function. However, little is known about how individual's genetic background interacts with environmental influences on vascular health, thereby making the interpretation of the relative importance of lifestyle interventions more complicated.
authors: 1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece. drnpapageorgiou@yahoo.com
authors: Nikolaos
authors: N
authors: Papageorgiou
authors: Dimitris
authors: D
authors: Tousoulis
authors: Emmanuel
authors: E
authors: Androulakis
authors: Aris
authors: A
authors: Giotakis
authors: Gerasimos
authors: G
authors: Siasos
authors: George
authors: G
authors: Latsios
authors: Christodoulos
authors: C
authors: Stefanadis
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008019:Life Style; D012307:Risk Factors; D040242:Risk Reduction Behavior; D014652:Vascular Diseases / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*