title: Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of Annona foetida Mart. (Annonaceae).
abstract: Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH(2)Cl(2) extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
authors: LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil. emmanoelvilaca@yahoo.com.br
authors: Emmanoel Vilaça
authors: EV
authors: Costa
authors: Maria Lúcia Belém
authors: ML
authors: Pinheiro
authors: Afonso Duarte Leão
authors: AD
authors: de Souza
authors: Andersson
authors: A
authors: Barison
authors: Francinete Ramos
authors: FR
authors: Campos
authors: Rodrigo Hinojosa
authors: RH
authors: Valdez
authors: Tânia
authors: T
authors: Ueda-Nakamura
authors: Benedito Prado Dias
authors: BP
authors: Filho
authors: Celso Vataru
authors: CV
authors: Nakamura
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry*; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology*; D002243:Carbolines / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D011743:Pyrimidines / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D001060:Aporphines; D002243:Carbolines; C570839:O-methylmoschatoline; D010936:Plant Extracts; D011743:Pyrimidines; D014344:Trypanocidal Agents; C508838:annomontine; C026980:liriodenine