title: Molecular phylogenetic and evolutionary analysis of Japanese encephalitis virus in China.
abstract: We elucidated the molecular epidemiology and evolution of Japanese encephalitis virus (JEV) strains isolated from 1949 to 2009 in China in this study. Three genotypes (I, III, V) were confirmed to be co-circulating in China in both high- and low-prevalence areas. Genotype III consisted of two clades (mainland clade and Taiwan clade). Compared to the mainland clade, genotype I and the Taiwan clade were newly introduced and evolved more rapidly. We also demonstrated that JEV strains in China, especially those in the mainland clade, were not only under purifying selection, but also probably under positive selection (aa 227 and 408 in the envelope protein).
authors: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China. shpchen@hotmail.com
authors: S P
authors: SP
authors: Chen
mesh_terms: D002681:China / Q000453:epidemiology; D004664:Encephalitis Virus, Japanese / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D004672:Encephalitis, Japanese / Q000453:epidemiology / Q000821:virology*; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D017720:Molecular Epidemiology; D010802:Phylogeny; D015995:Prevalence; D017422:Sequence Analysis, DNA; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D014759:Viral Envelope Proteins