title: Metabolic adaptation of Pseudomonas pseudoalcaligenes CECT5344 to cyanide: role of malate-quinone oxidoreductases, aconitase and fumarase isoenzymes.
abstract: In general, the biodegradation of a toxic compound by a micro-organism requires the concurrence of, at least, two features in the biological system: first, the capability of the micro-organism to metabolize the toxic compound, and secondly, the capacity to resist its toxic effect. Pseudomonas pseudoalcaligenes CECT5344 is a bacterium used in the biodegradation of cyanide because it is capable to use it as a nitrogen source. The present review is mainly focused on the putative role of iron-containing enzymes of the tricarboxylic acid cycle in cyanide resistance by P. pseudoalcaligenes CECT5344.
authors: Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de Universidad s/n, 10003 Cáceres, Spain.
authors: M Isabel
authors: MI
authors: Igeño
authors: Gracia
authors: G
authors: Becerra
authors: M Isabel
authors: MI
authors: Guijo
authors: Faustino
authors: F
authors: Merchán
authors: Rafael
authors: R
authors: Blasco
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism*; D000222:Adaptation, Physiological; D003486:Cyanides / Q000633:toxicity*; D005649:Fumarate Hydratase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D044205:Pseudomonas pseudoalcaligenes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism*
chemical_list: D003486:Cyanides; D010088:Oxidoreductases; C471971:malate dehydrogenase, FAD-dependent; D005649:Fumarate Hydratase; D000154:Aconitate Hydratase