title: In vivo activity of aryl ozonides against Schistosoma species.
abstract: We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
authors: Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland. jennifer.keiser@unibas.ch
authors: Jennifer
authors: J
authors: Keiser
authors: Katrin
authors: K
authors: Ingram
authors: Mireille
authors: M
authors: Vargas
authors: Jacques
authors: J
authors: Chollet
authors: Xiaofang
authors: X
authors: Wang
authors: Yuxiang
authors: Y
authors: Dong
authors: Jonathan L
authors: JL
authors: Vennerstrom
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D012548:Schistosoma haematobium / Q000187:drug effects*; D012550:Schistosoma mansoni / Q000187:drug effects*; D012553:Schistosomiasis haematobia / Q000188:drug therapy* / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: C503429:1,2,4-trioxane; D000871:Anthelmintics; D006571:Heterocyclic Compounds