title: Localised Mycobacterium ulcerans infection in four dogs.
abstract: Localised infection caused by Mycobacterium ulcerans is described in two Kelpies, a Whippet and a Koolie domiciled on the Bellarine Peninsula, Victoria, Australia. The diagnosis was confirmed using real-time polymerase chain reaction (PCR) targeting the M. ulcerans-specific insertion sequence (IS2404) in DNA extracted from swabs of ulcerated lesions in all cases. Where available, molecular typing confirmed that three of the dogs were infected with a strain of M. ulcerans that was indistinguishable from a disease-causing strain in people and other animals in Victoria. One dog was still undergoing treatment at the time of writing, but the remaining three dogs were successfully treated with a combination of surgical debridement and medical therapy in one case, and medical therapy alone in the other two. Investigation of the home environs of three of the dogs using real-time PCR revealed low amounts of M. ulcerans DNA in various environmental samples. Mycobacterium ulcerans infection should be included in the differential diagnoses of any ulcerated skin lesions in dogs that live in or visit endemic areas of Victoria and Queensland.
authors: University of Melbourne, Faculty of Veterinary Science, Parkville, Victoria, Australia. cob@catvet.net.au
authors: C R
authors: CR
authors: O'Brien
authors: E
authors: E
authors: McMillan
authors: O
authors: O
authors: Harris
authors: D P
authors: DP
authors: O'Brien
authors: C J
authors: CJ
authors: Lavender
authors: M
authors: M
authors: Globan
authors: A R
authors: AR
authors: Legione
authors: J A
authors: JA
authors: Fyfe
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D054312:Buruli Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D003131:Combined Modality Therapy / Q000662:veterinary; D004269:DNA, Bacterial / Q000235:genetics; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D019911:Mycobacterium ulcerans / Q000235:genetics / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial