title: Effect of photodynamic therapy and endostatin on human glioma xenografts in nude mice.
abstract: The aim of this study was to investigate the effect of endostar (a recombinant human endostatin) and photodynamic therapy (PDT) on gliomas. To establish glioma xenografts, human U251 glioma cells were injected into the brain of nude mice. Mice with MRI-confirmed glioma received hematoporphyrin monomethyl ether (HMME)-mediated PDT, daily injection of endostar or their combination, respectively. After treatment, tumor volume, the expression of HIF-1α, VEGF-A and apoptosis marker, and animal survival were examined. PDT and endostar treatment can prolong survival. Changes in induction of apoptosis, tumor growth and survival were more significant in PDT+endostar group. After PDT, HIF-1α and VEGF-A expressions were markedly increased. After endostar treatment, HIF-1α and VEGF-A expressions were significantly reduced. PDT in combination with endostar can significantly inhibit the growth of glioma xenografts. This approach may represent a promising strategy in the treatment of glioma.
authors: Department of Neurosurgery, The Fourth Affiliated Hospital, Haerbin Medical University, Harbin 150001, China.
authors: Qi
authors: Q
authors: Zhan
authors: Wu
authors: W
authors: Yue
authors: Shaoshan
authors: S
authors: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D043169:Endostatins / Q000008:administration & dosage*; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043169:Endostatins; D017319:Photosensitizing Agents