title: Direct molecule-specific glucose detection by Raman spectroscopy based on photonic crystal fiber.
abstract: This paper reports the first step toward the development of a glucose biosensor based on Raman spectroscopy and a photonic crystal fiber (PCF) probe. Historically, it has been very challenging to detect glucose directly by Raman spectroscopy due to its inherently small Raman scattering cross-section. In this work, we report the first quantitative glucose Raman detection in the physiological concentration range (0-25 mM) with a low laser power (2 mW), a short integration time (30 s), and an extremely small sampling volume (~50 nL) using the highly sensitive liquid-filled PCF probe. As a proof of concept, we also demonstrate the molecular specificity of this technique in the presence of a competing sugar, such as fructose. High sensitivity, flexibility, reproducibility, low cost, small sampling volume, and in situ remote sensing capability make PCF a very powerful platform for potential glucose detection based on Raman spectroscopy.
authors: Department of Electrical Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
authors: Xuan
authors: X
authors: Yang
authors: Alissa Y
authors: AY
authors: Zhang
authors: Damon A
authors: DA
authors: Wheeler
authors: Tiziana C
authors: TC
authors: Bond
authors: Claire
authors: C
authors: Gu
authors: Yat
authors: Y
authors: Li
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D005336:Fiber Optic Technology / Q000295:instrumentation; D005947:Glucose / Q000032:analysis*; D007834:Lasers; D015335:Molecular Probes / Q000737:chemistry*; D017785:Photons; D013059:Spectrum Analysis, Raman / Q000295:instrumentation
chemical_list: D015335:Molecular Probes; D005947:Glucose