title: MetalionRNA: computational predictor of metal-binding sites in RNA structures.
abstract: BACKGROUND
  Metal ions are essential for the folding of RNA molecules into stable tertiary structures and are often involved in the catalytic activity of ribozymes. However, the positions of metal ions in RNA 3D structures are difficult to determine experimentally. This motivated us to develop a computational predictor of metal ion sites for RNA structures.
  
  
  RESULTS
  We developed a statistical potential for predicting positions of metal ions (magnesium, sodium and potassium), based on the analysis of binding sites in experimentally solved RNA structures. The MetalionRNA program is available as a web server that predicts metal ions for RNA structures submitted by the user.
  
  
  BACKGROUND
  The MetalionRNA web server is accessible at http://metalionrna.genesilico.pl/.
authors: Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland.
authors: Anna
authors: A
authors: Philips
authors: Kaja
authors: K
authors: Milanowska
authors: Grzegorz
authors: G
authors: Lach
authors: Michal
authors: M
authors: Boniecki
authors: Kristian
authors: K
authors: Rother
authors: Janusz M
authors: JM
authors: Bujnicki
mesh_terms: D001665:Binding Sites; D007477:Ions / Q000737:chemistry / Q000378:metabolism*; D008670:Metals / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017423:Sequence Analysis, RNA; D012984:Software
chemical_list: D007477:Ions; D008670:Metals; D016337:RNA, Catalytic; D012313:RNA