title: Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese--a case control study.
abstract: BACKGROUND
  Interleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase the risk of MS. However, their effects on NMO have been less well studied.
  
  
  METHODS
  Fifty-two anti-aquaporin 4 antibody-positive NMO patients, 69 anti-aquaporin 4 antibody-negative conventional MS patients, and 131 controls were genotyped for the IL-17A rs2275913 and IL-17F rs763780 single nucleotide polymorphisms by DNA sequencing.
  
  
  RESULTS
  Significantly higher frequencies of the rs763780 T allele (p(uncorr)=0.011) and TT genotype (p(uncorr)=0.007, p(corr)=0.042) were observed in NMO patients versus controls.
  
  
  CONCLUSIONS
  The rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.
authors: Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, Guangzhou, Guangdong Province, China.
authors: Honghao
authors: H
authors: Wang
authors: Xiaonan
authors: X
authors: Zhong
authors: Kai
authors: K
authors: Wang
authors: Wei
authors: W
authors: Qiu
authors: Jin
authors: J
authors: Li
authors: Yongqiang
authors: Y
authors: Dai
authors: Xueqiang
authors: X
authors: Hu
mesh_terms: D000328:Adult; D017668:Age of Onset; D051401:Aquaporin 4 / Q000276:immunology*; D044466:Asian People; D001323:Autoantibodies / Q000032:analysis*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology; D009471:Neuromyelitis Optica / Q000235:genetics* / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D051401:Aquaporin 4; D001323:Autoantibodies; D020381:Interleukin-17; D004247:DNA