title: Direct amide formation from unactivated carboxylic acids and amines.
abstract: The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
authors: Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
authors: C Liana
authors: CL
authors: Allen
authors: A Rosie
authors: AR
authors: Chhatwal
authors: Jonathan M J
authors: JM
authors: Williams