title: Serum amyloid A low-density lipoprotein levels and smoking status in obese Japanese patients.
abstract: Serum amyloid A low-density lipoprotein (SAA-LDL) is formed by an oxidative interaction and is considered to be a new marker related to oxidative modification of LDL. As the effect of smoking on oxidized LDL is of concern, this study investigated the association between SAA-LDL  and smoking status. A total of 578 Japanese obese outpatients (mean ± SD age 50.5 ± 14.3 years) were studied. Smoking status was examined via a self-reported questionnaire. Cardio metabolic variables, including high-sensitivity Creactive protein (hsCRP), were analysed in addition  to SAA-LDL. There was an increasing trend in SAA-LDL levels from non- to ex- to current smokers, and significantly higher SAA-LDL levels were observed in current smokers versus non-smokers (median SAA-LDL level 36 μg/ml versus 28 μg/ml, respectively). This significant  difference was reduced after adjusting for multiple confounders, including lipid levels. Smoking may be associated with increased levels of SAA-LDL in an obese Japanese population, but further studies are needed.
authors: Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Centre, Kyoto, Japan. kazukotani@jichi.ac.jp
authors: K
authors: K
authors: Kotani
authors: N
authors: N
authors: Satoh-Asahara
authors: Y
authors: Y
authors: Kato
authors: R
authors: R
authors: Araki
authors: A
authors: A
authors: Himeno
authors: H
authors: H
authors: Yamakage
authors: K
authors: K
authors: Koyama
authors: M
authors: M
authors: Tanabe
authors: M
authors: M
authors: Oishi
authors: T
authors: T
authors: Okajima
authors: A
authors: A
authors: Shimatsu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010084:Oxidation-Reduction; D000685:Serum Amyloid A Protein / Q000031:analogs & derivatives*; D012907:Smoking / Q000097:blood*; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008077:Lipoproteins, LDL; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein; D002784:Cholesterol