title: Non-Hodgkin lymphoma of bone in an HIV-infected patient from Argentina.
abstract: BACKGROUND
  Human immunodeficiency virus (HIV)-infected patients are at higher risk for development of Non-Hodgkin's lymphoma (NHL). The estimated incidence of NHL in patients with acquired immunodeficiency syndrome (AIDS) is much higher when compared to the general population. Most AIDS-associated NHL are of intermediate- or high-grade B-cell type and involve extranodal sites more frequently. The most common sites are the central nervous system (CNS), gastrointestinal tract, liver, bone marrow and soft tissues.
  
  
  METHODS
  We describe a 42-year-old male with risk factors for HIV infection who presented with left leg pain and an osteolytic lesion of the left medial tibia. He was subsequently diagnosed with HIV disease and an open biopsy of his left tibia established the diagnosis of NHL.
  
  
  RESULTS
  After starting antiretroviral therapy followed by chemotherapy he achieved remission.
  
  
  CONCLUSIONS
  Bone lymphomas account for 3% of malignant bone tumors and 4-7% of all extranodal sites. NHL of bone has been infrequently described in patients with AIDS. To our knowledge, this is the first report of NHL of the bone in Argentina.
authors: Department of Internal Medicine and Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA. usandkovsky@unmc.edu
authors: Uriel
authors: U
authors: Sandkovsky
authors: Pablo Fernando
authors: PF
authors: Martin
authors: Emiliano
authors: E
authors: Bissio
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001118:Argentina; D001859:Bone Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006651:Histocytochemistry; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008853:Microscopy; D011859:Radiography
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents