title: Hydrangenone, a new isoprenoid with an unprecedented skeleton from Salvia hydrangea.
abstract: Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC(50) value of 1.4 μM against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.
authors: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran. m_moridi@sbu.ac.ir
authors: M Moridi
authors: MM
authors: Farimani
authors: Salman
authors: S
authors: Taheri
authors: Samad N
authors: SN
authors: Ebrahimi
authors: M Babak
authors: MB
authors: Bahadori
authors: Hamid R
authors: HR
authors: Khavasi
authors: Stefanie
authors: S
authors: Zimmermann
authors: Reto
authors: R
authors: Brun
authors: Matthias
authors: M
authors: Hamburger
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D045792:Norisoprenoids / Q000737:chemistry* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D027544:Salvia / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D045792:Norisoprenoids; C571249:hydrangenone