title: Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population.
abstract: Prostate cancer is the second most diagnosed cancer in men next to skin cancer in the developed world. Risk of disease varies most prominently with age, ethnicity, family history, and diet. Genetic polymorphism of some genes has been implicated in increasing the risk. The XPD (Xeroderma pigmentosum group D) gene codes for a DNA helicase involved in transcription and nucleotide excision repair. The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients. Blood sample from 150 prostate cancer patients, 150 from Prostate Hyper Plasia and equal number of samples from healthy control groups was collected from North India. The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI).
authors: Department of Biotechnology, Panjab University, Chandigarh, India. rcsobti@pu.ac.in
authors: Ranbir Chander
authors: RC
authors: Sobti
authors: Nega
authors: N
authors: Berhane
authors: Shiferaw
authors: S
authors: Melese
authors: Salih Abdul
authors: SA
authors: Mahdi
authors: Libsy
authors: L
authors: Gupta
authors: Hitender
authors: H
authors: Thakur
authors: Neha
authors: N
authors: Singh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012306:Risk; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human