title: Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats.
abstract: OBJECTIVE
  Previous studies have demonstrated the dual effects of strontium ranelate (SR) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of SR on osseointegration of titanium implant in ovariectomized rats.
  
  
  METHODS
  Twelve weeks after bilateral ovariectomy in female Sprague-Dawley rats, each animal received two titanium implants in the distal metaphysis of femur. All rats were then randomly divided into two groups: Control and SR (625 mg/kg/day). Twelve weeks after implantation, serum levels of osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP) 5b, implant osseointegration and peri-implant trabecular microarchitecture were analyzed by histomorphometry, micro-computerized tomography (micro-CT), and biomechanical test.
  
  
  RESULTS
  Compared with control, SR treatment increased serum levels of OCN by 29.2%, and decreased the levels of TRAP 5b by 25.5% in serum analysis; SR treatment increased percent bone volume by 63.1% and percent osseointegration by 48.3% in micro-CT assessment, and increased bone area density by 55.6% and bone-to-implant contact by 49.0% in histomorphometry; SR treatment also increased the maximal push-out force by 117.7% and the ultimate shear strength by 103.5% in push-out test.
  
  
  CONCLUSIONS
  Strontium ranelate treatment could improve titanium implant osseointegration in osteoporotic rats.
authors: The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
authors: Yunfeng
authors: Y
authors: Li
authors: Xudong
authors: X
authors: Li
authors: Guodong
authors: G
authors: Song
authors: Kan
authors: K
authors: Chen
authors: Guozhu
authors: G
authors: Yin
authors: Jing
authors: J
authors: Hu
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001696:Biomechanical Phenomena; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D005260:Female; D005269:Femur / Q000601:surgery; D007527:Isoenzymes / Q000097:blood; D008855:Microscopy, Electron, Scanning; D009942:Organometallic Compounds / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects*; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000188:drug therapy* / Q000601:surgery*; D010052:Ovariectomy; D019919:Prosthesis Implantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase; D013876:Thiophenes / Q000494:pharmacology*; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D050071:Bone Density Conservation Agents; D020099:Coated Materials, Biocompatible; D007527:Isoenzymes; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D015675:Osteocalcin; D014025:Titanium; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase