title: A new conjugated amide-dimer from the aerial parts of Piper submultinerve.
abstract: Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using (ΔTat/Rev)MC99 virus and 1A2 cell line system, whereas 2 was most active (EC₅₀ 35.1 µM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC₅₀ 50.8 µM.
authors: Department of Chemistry and Center for Innovation in Chemistry-PERCH-CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Saksit
authors: S
authors: Nobsathian
authors: Patoomratana
authors: P
authors: Tuchinda
authors: Darunee
authors: D
authors: Soorukram
authors: Manat
authors: M
authors: Pohmakotr
authors: Vichai
authors: V
authors: Reutrakul
authors: Chalobon
authors: C
authors: Yoosook
authors: Jitra
authors: J
authors: Kasisit
authors: Chanita
authors: C
authors: Napaswad
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line / Q000821:virology; D019281:Dimerization; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000378:metabolism; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007769:Lactams / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000475:Alkenes; D000577:Amides; D019380:Anti-HIV Agents; D005231:Fatty Acids, Unsaturated; D006574:Heterocyclic Compounds, 2-Ring; D007769:Lactams; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; C487927:aristolactam BII; C492480:guineensine; C577999:submultinamide A; C008778:pellitorine; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase