title: Catheter-related infection and pathogens of umbilical venous catheterization in a neonatal intensive care unit in China.
abstract: We studied the incidence of umbilical venous catheterization (UVC)-related infection and pathogens in a neonatal intensive care unit (NICU) in China. Patients were grouped into <2000-g UVC or <2000-g non-UVC groups or ≥2001-g UVC or ≥2001-g non-UVC groups. Blood culture and umbilical root skin swab culture were taken following UVC insertion and extraction. UVCs were removed after 7 days and cultures of UVC tips were performed then. A total of 516 patients were enrolled. The incidence of UVC-related septicemia was 9.5%. The incidence of UVC-related septicemia per 1000 UVC days was 13.6. No significant difference was noted between <2000-g UVC and <2000-g non-UVC groups and between ≥2001-g UVC group and ≥2001-g non-UVC groups, in the number of positive blood cultures and skin cultures, the percentage of catheter-related septicemia, the incidence of catheter-related septicemia per 1000 catheter days, and the increase in the number of positive cultures between two skin cultures following UVC insertion and extraction. The predominant pathogen in all cultures was gram-positive pathogens. Coagulase-negative Staphylococcus was the most frequently noted pathogen. UVC did not increase the incidence of catheter-related infection in the NICU. It is necessary to consider local pathogen spectrum when choosing antibiotic therapy before specific culture results become available.
authors: Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan, PR China. heiming_yan@yahoo.com.cn
authors: Ming-Yan
authors: MY
authors: Hei
authors: Xiao-Chun
authors: XC
authors: Zhang
authors: Xiang-Yu
authors: XY
authors: Gao
authors: Ling-Ling
authors: LL
authors: Zhao
authors: Zhi-Xiang
authors: ZX
authors: Wu
authors: Lang
authors: L
authors: Tian
authors: Yan-Juan
authors: YJ
authors: Tan
mesh_terms: D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000706:statistics & numerical data; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D007224:Infant Care / Q000706:statistics & numerical data; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology* / Q000382:microbiology