title: A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea.
abstract: During recent canine influenza surveillance in South Korea, a novel H3N1 canine influenza virus (CIV) that is a putative reassortant between pandemic H1N1 2009 and H3N2 CIVs was isolated. Genetic analysis of eight genes of the influenza virus revealed that the novel H3N1 isolate presented high similarities (99.1-99.9 %) to pandemic influenza H1N1, except for in the haemagglutinin (HA) gene. The HA gene nucleotide sequence of the novel CIV H3N1 was similar (99.6 %) to that of CIV H3N2 isolated in Korea and China. Dogs infected with the novel H3N1 CIV did not show any notable symptoms, in contrast to dogs infected with H3N2 CIV. Despite no visible clinical signs of disease, nasal shedding of virus was detected and the infected dogs presented mild histopathological changes.
authors: University of Science and Technology, Daejeon 305-350, Republic of Korea.|Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors: Daesub
authors: D
authors: Song
authors: Research Unit, Green Cross Veterinary Products, Yong-In 449-903, Republic of Korea.
authors: Hyoung-Joon
authors: HJ
authors: Moon
authors: National Veterinary Research and Quarantine Service, Anyang 430-824, Republic of Korea.
authors: Dong-Jun
authors: DJ
authors: An
authors: National Veterinary Research and Quarantine Service, Anyang 430-824, Republic of Korea.
authors: Hye-Young
authors: HY
authors: Jeoung
authors: Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Kwanak-gu, Seoul 151-742, Republic of Korea.
authors: Hyekwon
authors: H
authors: Kim
authors: Research Unit, Green Cross Veterinary Products, Yong-In 449-903, Republic of Korea.
authors: Min-Joo
authors: MJ
authors: Yeom
authors: Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors: Minki
authors: M
authors: Hong
authors: University of Science and Technology, Daejeon 305-350, Republic of Korea.|Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors: Jeong-Hyun
authors: JH
authors: Nam
authors: Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Kwanak-gu, Seoul 151-742, Republic of Korea.
authors: Seong-Jun
authors: SJ
authors: Park
authors: Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Kwanak-gu, Seoul 151-742, Republic of Korea.
authors: Bong-Kyun
authors: BK
authors: Park
authors: Bionote, Hwasung, Republic of Korea.
authors: Jin-Sik
authors: JS
authors: Oh
authors: International Vaccine Institute, Laboratory Science Division, Republic of Korea.
authors: Manki
authors: M
authors: Song
authors: Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors: Robert G
authors: RG
authors: Webster
authors: University of Science and Technology, Daejeon 305-350, Republic of Korea.|Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors: Jeong-Ki
authors: JK
authors: Kim
authors: Research Unit, Green Cross Veterinary Products, Yong-In 449-903, Republic of Korea.
authors: Bo-Kyu
authors: BK
authors: Kang
mesh_terms: D000818:Animals; D002353:Carrier State / Q000662:veterinary* / Q000821:virology; D016000:Cluster Analysis; D004285:Dogs; D009980:Influenza A virus / Q000235:genetics* / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics* / Q000302:isolation & purification*; D056910:Republic of Korea; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics; D017201:Virus Shedding
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins