title: Impaired diffusing capacity for carbon monoxide in children with type 1 diabetes: is this the first sign of long-term complications?
abstract: We assessed the presence of lung dysfunction in children with type 1 diabetes, evaluated as reduced diffusing capacity of the lung for carbon monoxide (DLCO), and its components: membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc). A total of 42 children, aged 15.6 ± 3.8 years, with type 1 diabetes for 8.3 ± 5.5 years, and 30 healthy age and sex-matched peers were recruited for the study. Lung volumes and spirometric dynamic parameters were assessed by plethysmography. Single-breath DLCO was measured according to international recommendation. DM and Vc volume were calculated. Lung volumes were significantly reduced in young patients with type 1 diabetes when compared to controls. Moreover, DLCO was reduced in patients compared to controls (78% ± 16% vs. 120% ± 1%, P = 0.0001). However, when differentiating DM and Vc compartments, we observed a significant impairment only about Vc (34 ± 20 ml vs. 88 ± 18 ml; P = 0.0001), while no difference was observed about DM compartment (23 ± 4 vs. 26 ± 3 ml/min/mmHg, P = 0.798). Whether this might be seen as the "first" sign of microangiopathic involvement in patients with type 1 diabetes has to be confirmed on larger groups but is still fascinating. Meanwhile, we suggest to screen DLCO in all patients with type 1 diabetes.
authors: Department of Paediatrics, "Luigi Sacco Hospital", University of Milano, Milan, Italy. scaramuzza.andrea@hsacco.it
authors: Andrea E
authors: AE
authors: Scaramuzza
authors: Marco
authors: M
authors: Morelli
authors: Maurizio
authors: M
authors: Rizzi
authors: Simona
authors: S
authors: Borgonovo
authors: Alessandra
authors: A
authors: De Palma
authors: Chiara
authors: C
authors: Mameli
authors: Elisa
authors: E
authors: Giani
authors: Silvia
authors: S
authors: Beretta
authors: Gian Vincenzo
authors: GV
authors: Zuccotti
mesh_terms: D000293:Adolescent; D002248:Carbon Monoxide / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D048909:Diabetes Complications / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D004058:Diffusion; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011653:Pulmonary Diffusing Capacity; D055815:Young Adult
chemical_list: D002248:Carbon Monoxide