title: Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas.
abstract: Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n=37). Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.
authors: Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea.
authors: J H
authors: JH
authors: Kim
authors: J H
authors: JH
authors: Hur
authors: S M
authors: SM
authors: Lee
authors: K S
authors: KS
authors: Im
authors: N H
authors: NH
authors: Kim
authors: J H
authors: JH
authors: Sur
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000276:immunology* / Q000378:metabolism; D002277:Carcinoma / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D018450:Disease Progression; D004283:Dog Diseases / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D004285:Dogs; D004815:Epidermal Growth Factor / Q000276:immunology / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology* / Q000378:metabolism; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D051858:Forkhead Transcription Factors; D011960:Receptors, Estrogen; D004815:Epidermal Growth Factor