title: An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera.
abstract: From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at a concentration of 43.4 µM.
authors: Departamento de Química, Universidade Federal do Amazonas, Av. Gal. Rodrigo Otávio, Manaus, Amazonas, Brazil. hector_ferreira86@yahoo.com.br
authors: Hector Henrique Ferreira
authors: HH
authors: Koolen
authors: Elzalina Ribeiro
authors: ER
authors: Soares
authors: Felipe Moura Araújo da
authors: FM
authors: Silva
authors: Antonia Queiroz Lima de
authors: AQ
authors: Souza
authors: Lívia Soman de
authors: LS
authors: Medeiros
authors: Edson Rodrigues
authors: ER
authors: Filho
authors: Richardson Alves de
authors: RA
authors: Almeida
authors: Ismael Alexandre
authors: IA
authors: Ribeiro
authors: Cláudia do Ó
authors: Cdo Ó
authors: Pessoa
authors: Manoel Odorico de
authors: MO
authors: Morais
authors: Patrícia Marçal da
authors: PM
authors: Costa
authors: Afonso Duarte Leão de
authors: AD
authors: Souza
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D019343:Citric Acid / Q000302:isolation & purification; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification; D004305:Dose-Response Relationship, Drug; D060026:Endophytes / Q000737:chemistry; D004875:Ergosterol / Q000031:analogs & derivatives / Q000302:isolation & purification; D020462:Gliocladium / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification; D010840:Phytosterols / Q000302:isolation & purification; D031451:Strychnos / Q000382:microbiology*
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D054659:Diketopiperazines; D010456:Peptides, Cyclic; D010840:Phytosterols; C000590678:cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether; D019343:Citric Acid; C006954:cerevisterol; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol