title: Distribution of HPV genotypes in Slovenian patients with anal carcinoma: preliminary results.
abstract: The aim of the present study was to obtain first data on the distribution of human papillomavirus (HPV) genotypes in patients with anal cancer (AC) in Slovenia. A total of 21 samples of AC (16 archival FFPE samples and 5 fresh-frozen tissue samples) collected from the same number of patients were analysed. All samples were tested for the presence of HPV DNA using a consensus GP5+/ GP6+ PCR and HPV genotypes determined by the INNO LiPA HPV Genotyping Extra test, capable of recognizing 28 different alfa-HPV genotypes. All 21 AC samples were HPV DNA positive. The most frequent HPV genotype, found in 19/21 AC samples, was HPV-16. Only low-risk HPV-6 was detected in one sample and infection with high-risk HPV-52 and low-risk HPV-61 was identified in one sample. Prophylactic HPV vaccination with currently available vaccines could potentially prevent the great majority of anal cancers in Slovenia.
authors: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia.
authors: Kristina Fujs
authors: KF
authors: Komloš
authors: Boštjan J
authors: BJ
authors: Kocjan
authors: Pavle
authors: P
authors: Košorok
authors: Tomaž
authors: T
authors: Rus
authors: Janez
authors: J
authors: Toplak
authors: Matic
authors: M
authors: Bunič
authors: Mario
authors: M
authors: Poljak
mesh_terms: D001005:Anus Neoplasms / Q000517:prevention & control / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000517:prevention & control; D053918:Papillomavirus Vaccines; D015995:Prevalence; D017524:Slovenia
chemical_list: D053918:Papillomavirus Vaccines