title: Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report.
abstract: Eccrine porocarcinoma is a potentially fatal form of sweat gland carcinoma, due to its propensity to metastasize through lymph vessels. The authors report the case of a 69-year-old female who presented with swelling of the right leg and an ulcerated lesion of the right great toe. The initial histologic diagnosis was invasive squamous cell carcinoma. On follow-up, the patient developed lymphangitic tumor spread in the right leg, associated with right inguinal lymphadenopathy and lesions in vulva and flank. Reevaluation of the toe lesion led to a revised diagnosis of eccrine porocarcinoma. The patient also had 2 basal cell carcinomas of the multicentric/superficial type in the skin overlying the left breast. Past history included chronic ingestion of liquore arsenic (Fowler's solution) in early adulthood as treatment for dermatitis herpetiformis.
authors: Pontificia Universidad Javeriana, Bogota, Colombia.
authors: Yuly
authors: Y
authors: Ramirez
authors: Giovanni
authors: G
authors: Fellegara
authors: Marianna
authors: M
authors: Bugiani
mesh_terms: D000368:Aged; D020261:Arsenic Poisoning / Q000209:etiology*; D018053:Arsenites / Q000009:adverse effects* / Q000627:therapeutic use; D002273:Carcinogens; D002280:Basal Cell Carcinoma / Q000150:complications / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D057090:Eccrine Porocarcinoma / Q000150:complications / Q000209:etiology / Q000556:secondary*; D005260:Female; D006801:Humans; D016849:Keratitis, Herpetic / Q000188:drug therapy; D008198:Lymph Nodes / Q000473:pathology; D008205:Lymphangitis / Q000150:complications / Q000209:etiology / Q000473:pathology*; D009378:Neoplasms, Multiple Primary; D017680:Potassium Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000150:complications / Q000209:etiology / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000150:complications / Q000209:etiology / Q000473:pathology*
chemical_list: D018053:Arsenites; D002273:Carcinogens; D017680:Potassium Compounds; C009003:potassium arsenite solution