title: Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.
abstract: LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
authors: Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing 210004, China.
authors: Min
authors: M
authors: Zhang
authors: Hai-Ming
authors: HM
authors: Zhao
authors: Zhen-Ying
authors: ZY
authors: Qin
authors: Rui
authors: R
authors: Qin
authors: Xiao-Hui
authors: XH
authors: Chen
authors: Ya-Ping
authors: YP
authors: Zhao
authors: Chun-Mei
authors: CM
authors: Zhang
authors: Chun-Lin
authors: CL
authors: Gao
authors: Chun
authors: C
authors: Zhu
authors: Chen-Bo
authors: CB
authors: Ji
authors: Xin-Guo
authors: XG
authors: Cao
authors: Xi-Rong
authors: XR
authors: Guo
mesh_terms: D041721:3T3-L1 Cells; D054392:Adipokines / Q000494:pharmacology*; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007333:Insulin Resistance / Q000235:genetics; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis; D052243:Resistin / Q000494:pharmacology; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D054392:Adipokines; D051017:Apoptosis Regulatory Proteins; D005230:Fatty Acids, Nonesterified; C570850:LYR motif containing 1 protein, mouse; D012333:RNA, Messenger; D052243:Resistin; D045162:Thiazolidinediones; D014409:Tumor Necrosis Factor-alpha; D000077154:Rosiglitazone