title: Recombinant chromosome 7 in a mosaic 45,X/47,XXX patient.
abstract: Individuals with pericentric inversions are at risk for producing offspring with chromosomal gains and losses, while those carrying paracentric inversions usually produce unviable gametes [Madan, 1995]. In this current study, we present a newborn with dysmorphic features and malformations, whose karyotype showed an abnormal copy of chromomosome 7 described at first as add(7)(q32) as well as mos 45,X/47,XXX. Array comparative genomic hybridization (CGH) revealed an interstitial deletion in the long arm of chromosome 7 involving bands q35 to q36.3 but retaining the 7q subtelomere. The patient's deletion is believed to be due to meiotic recombination in the inversion loop in the phenotypically normal father who seems to carry two paracentric inversions in the long arm of chromosome 7, which was described as rec(7)(7pter- > q35::q36.3- > 7qter)pat. The abnormal copy of chromosome 7 in the father has been described as: der(7)(7pter- > q22.1::q36.3- > q35::q22.1- > q35::q36.3- > 7qter). This is a unique karyotype that to our knowledge has not been previously reported in the literature and predisposes to meiotic recombination that can result in deletions or duplications of 7q35-36.
authors: Laboratory of Clinical Cytogenetics, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. ctirado@mednet.ucla.edu
authors: Carlos A
authors: CA
authors: Tirado
authors: Garrett
authors: G
authors: Gotway
authors: Emmanuel
authors: E
authors: Torgbe
authors: Santha
authors: S
authors: Iyer
authors: Stephanie
authors: S
authors: Dallaire
authors: Taylor
authors: T
authors: Appleberry
authors: Mohamed
authors: M
authors: Suterwala
authors: Rolando
authors: R
authors: Garcia
authors: Federico
authors: F
authors: Valdez
authors: Sangeeta
authors: S
authors: Patel
authors: Prasad
authors: P
authors: Koduru
mesh_terms: D002872:Chromosome Deletion; D007446:Chromosome Inversion / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics; D055028:Comparative Genomic Hybridization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D059785:Karyotype; D008540:Meiosis; D009030:Mosaicism; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000235:genetics; D014314:Trisomy / Q000235:genetics