title: The effect of Tinospora crispa on serum glucose and insulin levels in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To determine the effects of Tinospora crispa on serum glucose and insulin levels in healthy subjects and patients with type 2 diabetes mellitus.
  
  
  METHODS
  Serum from 10 healthy subjects and 10 diabetic participants, who had fasted overnight, were obtained every 30-60 minutes during the 3 hours of continued fasting and during the 3 hours after ingestion of 75 g of glucose with or without ingestion of 125 or 250 g of Tinospora crispa dry powder capsule. Glucose and Insulin levels were analyzed and the areas under the curve for mean serum glucose and insulin levels were calculated.
  
  
  RESULTS
  The areas under the curve of mean serum glucose and insulin levels in both healthy and diabetic participants were not significantly different between with or without Tinospora crispa dry powder capsule. In diabetic participants the area under the curve of glucose was slightly lesser when 250 mg of Tinospora crispa was ingested, but not reaching statistical significance (478 and 444 mg min/ml, resp., P = 0.57).
  
  
  CONCLUSIONS
  The results suggest that Tinospora crispa ingestion cannot affect serum glucose and insulin levels in healthy subjects or patients with type 2 diabetes mellitus.
authors: Department of Medicine, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand.
authors: Theerawut
authors: T
authors: Klangjareonchai
authors: Chulaporn
authors: C
authors: Roongpisuthipong
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D031610:Tinospora
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose