title: Regioselective C-H bond functionalizations of acridines using organozinc reagents.
abstract: Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.
authors: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors: Isao
authors: I
authors: Hyodo
authors: Mamoru
authors: M
authors: Tobisu
authors: Naoto
authors: N
authors: Chatani
mesh_terms: D000166:Acridines / Q000737:chemistry*; D000478:Alkylation; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000166:Acridines; D009942:Organometallic Compounds; D015032:Zinc