title: Dendritic cells in experimental renal inflammation--Part I.
abstract: Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. While descriptions of cells with dendritic morphology in rodent kidneys date back to the early 1970s, a network of DCs in the mouse kidney has only recently been described. DCs acquire distinct phenotypic and functional characteristics depending on the microenvironment and the disease stages. Concomitantly, their communication with cells of the adaptive immunity might have tissue-protective or tissue-deleterious consequences. This review summarizes results from recent studies on the role of DCs in experimental renal inflammation.
authors: Division of Nephrology, University Hospital Zurich, and Institute of Anatomy, University of Zurich, Zurich, Switzerland.
authors: Maja
authors: M
authors: Lindenmeyer
authors: Elfriede
authors: E
authors: Noessner
authors: Peter J
authors: PJ
authors: Nelson
authors: Stephan
authors: S
authors: Segerer
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D009393:Nephritis / Q000276:immunology* / Q000473:pathology*