title: Alterations in cell proliferation related gene expressions in gastric cancer.
abstract: Gastric cancer remains the fourth most prevalent cancer and the second leading cause of cancer-related death in the world. The predominant form of gastric cancer is adenocarcinoma, which originates from glandular epithelium of the gastric mucosa. The major risk factors for gastric cancer include diet, individual genetic variation, and, most importantly, infection with Helicobacter pylori (H. pylori). Certain strains of H. pylori assisted by some of its virulence factors seem to play a critical role in gastric cancer development. Several of these H. pylori virulence factors, which influence cellular proliferation signaling, have been identified. In addition, changes in the expression of several cell proliferation regulating genes accompany or cause the progression of gastric cancer. These changes include modifications of cell cycle regulators, oncogene activation, tumor suppressor inactivation, and miRNA profile alterations. Many of these changes result from H. pylori infection, although their impact on the cellular proliferation system underlying gastric cancer development has not yet been fully elucidated. We review certain features of gastric cancer, the role of H. pylori infection in its etiology and pathogenesis, and gene expression changes during gastric carcinogenesis.
authors: Research Institute, National Cancer Center, Gyeonggido, Republic of Korea.
authors: Kyungtae
authors: K
authors: Kim
authors: Kyung-Hee
authors: KH
authors: Chun
authors: Pann-Ghill
authors: PG
authors: Suh
authors: In-Hoo
authors: IH
authors: Kim
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D002453:Cell Cycle; D049109:Cell Proliferation; D005753:Gastric Mucosa / Q000473:pathology; D016481:Helicobacter Infections / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors