title: Molecular properties of hybrid macromolecular antioxidants: dextran hydrophobically modified by sterically hindered phenols.
abstract: The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity -polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic. filippov@imc.cas.cz
authors: S K
authors: SK
authors: Filippov
authors: B
authors: B
authors: Porsch
authors: O Yu
authors: OY
authors: Sergeeva
authors: A S
authors: AS
authors: Olifirenko
authors: S B
authors: SB
authors: Lesnichin
authors: N S
authors: NS
authors: Domnina
authors: E A
authors: EA
authors: Komarova
authors: A V
authors: AV
authors: Lezov
authors: V M
authors: VM
authors: Garamus
authors: Z
authors: Z
authors: Walterova
authors: P
authors: P
authors: Stepanek
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002850:Chromatography, Gel; D003911:Dextrans / Q000737:chemistry*; D057446:Hydrodynamics; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D033363:Neutron Diffraction; D010636:Phenols / Q000737:chemistry*; D012542:Scattering, Radiation; D053838:Scattering, Small Angle; D014783:Viscosity
chemical_list: D000975:Antioxidants; D003911:Dextrans; D010636:Phenols