title: Influence of maternal glycemia on intrauterine fetal adiposity distribution after a normal oral glucose tolerance test at 28 weeks gestation.
abstract: OBJECTIVE
  To examine the relationship between maternal glucose levels and intrauterine fetal adiposity distribution in women with a normal oral glucose tolerance test (OGTT) at 28 weeks gestation.
  
  
  METHODS
  We recruited 231 women with a singleton pregnancy. At 28 and 37 weeks gestation, sonographic measurements of fetal body composition were performed. Multiple regression analysis was used to study the influence of different maternal variables on fetal adiposity distribution.
  
  
  RESULTS
  Maternal glucose levels correlated with the fetal abdominal subcutaneous tissue measurements (r = 0.2; P = 0.014) and with birth weight (r = 0.1; P = 0.04). Maternal glucose levels did not correlate with the fetal mid-thigh muscle thickness and mid-thigh subcutaneous tissue measurements.
  
  
  CONCLUSIONS
  We found that in nondiabetic women maternal glucose levels not only influence fetal adiposity and birth weight, but also influence the distribution of fetal adiposity. This supports previous evidence that maternal glycemia is a key determinant of intrauterine fetal programming.
authors: UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin 8, Ireland. drnfarah@gmail.com
authors: Nadine
authors: N
authors: Farah
authors: Jennifer
authors: J
authors: Hogan
authors: Vicky
authors: V
authors: O'Dwyer
authors: Bernard
authors: B
authors: Stuart
authors: Mairead
authors: M
authors: Kennelly
authors: Michael J
authors: MJ
authors: Turner
mesh_terms: D000005:Abdomen / Q000196:embryology; D000273:Adipose Tissue / Q000196:embryology*; D050154:Adiposity; D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D008137:Longitudinal Studies; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011446:Prospective Studies; D050151:Subcutaneous Fat / Q000196:embryology; D013848:Thigh / Q000196:embryology
chemical_list: D001786:Blood Glucose