title: Detection of DNA hybridization on chemically modified graphene platforms.
abstract: The increasing demand for simple, low-cost, rapid, sensitive and label-free methods for the detection of DNA sequences and the presence of single nucleotide polymorphisms (SNPs) has become an important issue in biomedical research. In this work, we studied the performances of several chemically modified graphene nanomaterials as sensing platforms by using the electrochemical impedance spectroscopy technique for the detection. We employed a hairpin DNA as a highly selective probe for the detection of SNP correlated to Alzheimer's disease. We believe that our findings may present a foundation for further research and development in graphene-based impedimetric biosensing.
authors: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
authors: Marcella
authors: M
authors: Giovanni
authors: Alessandra
authors: A
authors: Bonanni
authors: Martin
authors: M
authors: Pumera
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D017931:DNA Primers; D006108:Graphite / Q000737:chemistry*; D049329:Nanostructures; D009693:Nucleic Acid Hybridization; D020641:Polymorphism, Single Nucleotide
chemical_list: D017931:DNA Primers; D006108:Graphite; D004247:DNA