title: Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks.
abstract: The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.
authors: Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland, and F. Hoffmann-La Roche AG, pRED, Discovery Chemistry, CH-4070 Basel, Switzerland.
authors: Johannes A
authors: JA
authors: Burkhard
authors: Carine
authors: C
authors: Guérot
authors: Henner
authors: H
authors: Knust
authors: Erick M
authors: EM
authors: Carreira
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis*; D004988:Ethers, Cyclic / Q000737:chemistry; D006536:Heptanes / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D001372:Aza Compounds; D004988:Ethers, Cyclic; D006536:Heptanes; D013141:Spiro Compounds; C005287:oxetane