title: Plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys.
abstract: OBJECTIVE
  To investigate plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys.
  
  
  METHODS
  12 donkeys naturally infected with strongyle nematodes.
  
  
  METHODS
  The pour-on formulation of eprinomectin approved for use in cattle was administered topically to donkeys at a dosage of 0.5 mg/kg. Heparinized blood samples and hair samples were collected at various times between 1 hour and 40 days after administration. Samples were analyzed via high-performance liquid chromatography with fluorescence detection. Fecal strongyle egg counts were performed by use of a modified McMaster technique before and at weekly intervals for 8 weeks after treatment.
  
  
  RESULTS
  Plasma concentration and systemic availability of eprinomectin were relatively higher in donkeys, compared with values reported for other animal species. Concerning the anthelmintic efficacy against strongyle nematodes, eprinomectin was completely effective (100%) on days 7 and 14 and highly effective (> 99%) until the end of the study at 56 days after treatment. No abnormal clinical signs or adverse reactions were observed for any donkeys after treatment.
  
  
  CONCLUSIONS
  Eprinomectin had excellent safety. The relatively high plasma concentration after topical administration could result in use of eprinomectin for the control and treatment of parasitic diseases in donkeys.
authors: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu 09100 Aydin, Turkey. cengizgokbulut@yahoo.com
authors: Cengiz
authors: C
authors: Gokbulut
authors: Antonio
authors: A
authors: Di Loria
authors: Necati
authors: N
authors: Gunay
authors: Roberto
authors: R
authors: Masucci
authors: Vincenzo
authors: V
authors: Veneziano
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D018397:Equidae / Q000097:blood / Q000378:metabolism / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006197:Hair / Q000737:chemistry*; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D017206:Strongylida Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D013320:Strongyloidea / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin