title: Effect of intraarterial chemotherapy on retinoblastoma-induced retinal detachment.
abstract: OBJECTIVE
  To study the effect of intraarterial chemotherapy (IAC) on retinoblastoma-induced retinal detachment.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series including 15 patients, with intraarterial (ophthalmic artery) chemotherapy as the intervention. Resolution of retinal detachment was the main outcome measure.
  
  
  RESULTS
  Of 15 patients with retinoblastoma-induced retinal detachment managed with IAC, 7 (47%) presented with total retinal detachment and 8 (53%) with partial detachment. The eyes were classified as International Classification of Retinoblastoma group C (n = 2, 13%), group D (n = 4, 27%), and group E (n = 5, 33%). There were 4 eyes (27%) that received IAC as secondary treatment after the failure of other treatment methods. After IAC, all tumors showed regression. Of the 7 eyes with initial total retinal detachment, complete resolution of fluid was found in 3 (43%) and partial resolution in 4 (57%). Of the 8 eyes with initial partial retinal detachment, complete resolution of subretinal fluid was found in all 8 (100%), but 1 eye later developed recurrent subretinal fluid. The mean interval to complete resolution of subretinal fluid was 2 months. Globe salvage was achieved in 5 of 7 eyes (71%) with total retinal detachment and 6 of 8 eyes (75%) with partial retinal detachment.
  
  
  CONCLUSIONS
  Eyes with retinoblastoma-induced total or partial retinal detachment showed complete resolution of detachment after IAC in 43% and 100%, respectively.
authors: Ocular Oncology Service, Wills Eye Institute, Philadelphia, PA, USA. carol.shields@shieldsoncology.com
authors: Carol L
authors: CL
authors: Shields
authors: Swathi
authors: S
authors: Kaliki
authors: Sanket U
authors: SU
authors: Shah
authors: Carlos G
authors: CG
authors: Bianciotto
authors: Pascal
authors: P
authors: Jabbour
authors: Jerry A
authors: JA
authors: Shields
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007269:Injections, Intra-Arterial; D008297:Male; D012163:Retinal Detachment / Q000188:drug therapy* / Q000209:etiology; D019572:Retinal Neoplasms / Q000150:complications / Q000188:drug therapy*; D012175:Retinoblastoma / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents