title: [Physical training as an effective way to protect the heart against ischaemia].
abstract: The findings from experimental animal studies show that regular physical trainings can protect via preconditioning the heart against the ischaemia-reperfusion (IR) injury. It is not clear if the cellular mechanism is the same as in the case of ischaemic preconditioning, but the final effect is the same, i.e. a stress stimulus, in this case a repeated effort leaves the heart with the 'memory', which translates into an increased resistance to ischaemia. At present, the precise mechanism responsible for training-induced cardioprotection is not clear. Candidate factors responsible for this cardioprotection are numerous and include collateral circulation development, enhanced ER stress proteins, increased COX-2 activity, increased heat shock protein (HSP-72) levels, increased activity of mitoK-ATP and sarcoK-ATP channels, and increased myocardial antioxidative capacity. The studies performed so far have suggested that MnSOD activity and increased sarcoK-ATP expression did play a role in exercise-induced cardioprotection. There may exist some other mechanisms responsible for this type of cardioprotection, but finding them will be possible only through further relevant studies. The paper presents the up-to-date knowledge in this field.
authors: Klinika Rehabilitacji Kardiologicznej i Elektrokardiologii Nieinwazyjnej, Instytut Kardiologii, Warszawa. drkubacka@wp.pl
authors: Iwona
authors: I
authors: Korzeniowska Kubacka
mesh_terms: D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000517:prevention & control*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008955:Models, Cardiovascular; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D010807:Physical Endurance / Q000502:physiology*; D013997:Time Factors