title: Pertussis booster vaccine for adolescents and young adults in São Paulo, Brazil.
abstract: OBJECTIVE
  To develop a model to assess different strategies of pertussis booster vaccination in the city of São Paulo.
  
  
  METHODS
  A dynamic stationary age-dependent compartmental model with waning immunity was developed. The "Who Acquires Infection from Whom" matrix was used to modeling age-dependent transmission rates. There were tested different strategies including vaccine boosters to the current vaccination schedule and three of them were reported: (i) 35% coverage at age 12, or (ii) 70% coverage at age 12, and (iii) 35% coverage at age 12 and 70% coverage at age 20 at the same time.
  
  
  RESULTS
  The strategy (i) achieved a 59% reduction of pertussis occurrence and a 53% reduction in infants while strategy (ii) produced 76% and 63% reduction and strategy (iii) 62% and 54%, respectively.
  
  
  CONCLUSIONS
  Pertussis booster vaccination at age 12 proved to be the best strategy among those tested in this study as it achieves the highest overall reduction and the greatest impact among infants who are more susceptible to pertussis complications.
authors: Departamento de Epidemiologia, Universidade de São Paulo, São Paulo, Brasil. angelacf.freitas@gmail.com
authors: Angela Carvalho
authors: AC
authors: Freitas
authors: Valdir
authors: V
authors: Okano
authors: Júlio Cesar Rodrigues
authors: JC
authors: Pereira
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001938:Brazil / Q000453:epidemiology; D002648:Child; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000706:statistics & numerical data*; D032541:Mass Vaccination; D008962:Models, Theoretical; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D014505:Urban Population; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D055815:Young Adult
chemical_list: D010567:Pertussis Vaccine