title: Structural and functional features of Streptolysin O.
abstract: Streptolysin O, a 63 kDa exotoxin coded by slo gene, is a well-characterised thiol-activated cytolysin, which damages cholesterol-containing membranes resulting in disruption and lysis of the target cell. On the basis of homology model and secondary structure analysis, the toxin has four domains of which domain 4 is of particular importance and is directly linked to domain 2 by a glycine linker and remained consistent in initial membrane recognition. Domain 4 reduces the hydrophobic ratio when compared with its template, which would affect the activity of the toxin at low pH.
authors: Centre of Biotechnology and Microbiology, University of Peshawar, Khyber Pukhtun Khwa, Pakistan. ahmad.biotech@yahoo.com
authors: Ashfaq
authors: A
authors: Ahmad
authors: Ghosia
authors: G
authors: Lutfullah
authors: Roshan
authors: R
authors: Ali
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry; D001483:Base Sequence; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013301:Streptolysins / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D013301:Streptolysins; C025964:streptolysin O