title: [Corynebacterium pseudodiphtheriticum causing severe pneumonia in secondary immunoglobulin deficiency].
abstract: BACKGROUND
  Corynebacterium pseudodiphtheriticum is of increasing importance because of the rising number of immunocompromised patients. Pneumonia, but also endocarditis, urinary tract infections or keratitis can be caused by this bacteria in case of immunosuppression. Taking corynebacterium pseudodiphtheriticum into consideration as causitive agent provides for a fast onset of targeted antibiotic therapy.
  
  
  METHODS
  A 69-year-old man with immunoglobulin deficiency due to a chronic lymphocytic leukemia presented with typical clinical, laboratory and imaging evidence of pneumonia.
  
  
  METHODS
  Corynebacterium pseudodiphtheriticum was detected as causative agent. After a prolongated course targeted antibiotic therapy and immunoglobulin substitution resulted in full recovery of the patient.
  
  
  CONCLUSIONS
  In immunocompromised patients Corynebacterium pseudodiphtheriticum should be taken into consideration as causative bacterium of pneumonia. Especially, immunoglobuline deficiency seems to be associated with pneumonia caused by Corynebacterium pseudodiphtheriticum. Therefore, immunoglobulin substitution as well as a targeted antibiotic therapy should be considered.
authors: Pneumologie und Beatmungsmedizin, Thoraxklinik Heidelberg. daniela.gompelmann@thoraxklinik-heidelberg.de
authors: D
authors: D
authors: Gompelmann
authors: J
authors: J
authors: Kappes
authors: C P
authors: CP
authors: Heussel
authors: P A
authors: PA
authors: Schnabel
authors: F J F
authors: FJ
authors: Herth
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001431:Bacteriological Techniques; D003354:Corynebacterium Infections / Q000175:diagnosis* / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000175:diagnosis* / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000276:immunology*; D016133:Polymerase Chain Reaction; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab