title: Final height in a prospective trial of late steroid withdrawal after pediatric renal transplantation treated with cyclosporine and mizoribine.
abstract: A prospective trial of corticosteroid (steroid) withdrawal after pediatric renal transplantation was started in 1990. Fifty-eight recipients with functioning grafts reached their final height. They were transplanted at a mean age of 10.7 yr. Immunosuppressive therapy with CyA, MP, and MZ was started after transplantation. MP was reduced to an alternate-day dose in 49 patients and was withdrawn in 23. Their mean height SDS was -2.4 at the time of transplantation and -2.1 at their final height. Mean final height was 157.9 cm in men and 147.6 cm in women. In 18 patients who had been withdrawn from MP for more than two yr before reaching final height, mean age at transplantation was 8.9 yr. Their mean height SDS of -2.2 at the time of transplantation increased to -1.6 at their final height (p = 0.02), and mean final height was 163.8 cm in men and 147.8 cm in women. The height SDS in all 58 patients was maintained during the immunosuppressive therapy with steroid minimization, and final height SDS increased in recipients older than five yr at transplantation with steroid withdrawal.
authors: Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan. motoyan@basil.ocn.ne.jp
authors: Osamu
authors: O
authors: Motoyama
authors: Akira
authors: A
authors: Hasegawa
authors: Atsushi
authors: A
authors: Aikawa
authors: Seiichirou
authors: S
authors: Shishido
authors: Masataka
authors: M
authors: Honda
authors: Kazuo
authors: K
authors: Tsuzuki
authors: Tsuneo
authors: T
authors: Kinukawa
authors: Motoshi
authors: M
authors: Hattori
authors: Osamu
authors: O
authors: Ogawa
authors: Toshio
authors: T
authors: Yanagihara
authors: Kazuhide
authors: K
authors: Saito
authors: Kota
authors: K
authors: Takahashi
authors: Shinichi
authors: S
authors: Ohshima
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000187:drug effects*; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007564:Japan; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D012263:Ribonucleosides / Q000009:adverse effects / Q000627:therapeutic use*; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D012263:Ribonucleosides; D013256:Steroids; C010052:mizoribine; D016572:Cyclosporine