title: A characterization of the relationship of ovarian reserve markers with age.
abstract: OBJECTIVE
  To identify markers of ovarian age that best match the pattern of oocyte loss seen in histology specimens.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University.
  
  
  METHODS
  Caucasian women (n = 252) aged 25-45 years.
  
  
  METHODS
  none.
  
  
  METHODS
  The relationship between antral follicle count (AFC), antimüllerian hormone (AMH), inhibin B, FSH, and E(2) with age was estimated using the power model, which previously has been shown to most accurately describe oocyte loss in histologic specimens. The power model was fit to each marker and used to compare the rates of change at ages 30 and 40 with the histologic pattern. Among those markers following the pattern, R(2) was used to compare the degree of relationship with age.
  
  
  RESULTS
  Both AMH levels and AFC exhibited significant progressive declines with age. The average rates of loss per year for AFC and AMH were, respectively, -0.57 and -1.09 at age 30, and -1.33 and -3.06 at age 40. FSH, inhibin B, and E(2) did not exhibit progressive rates of change. The R(2) for AFC was 27.3% and for AMH was 22.7%.
  
  
  CONCLUSIONS
  Only AFC and AMH follow the pattern of oocyte loss observed histologically. Although AMH may be more cost-effective, AFC is a slightly more accurate noninvasive measure for ovarian aging.
authors: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA. rosenm@obgyn.ucsf.edu
authors: Mitchell P
authors: MP
authors: Rosen
authors: Erica
authors: E
authors: Johnstone
authors: Charles E
authors: CE
authors: McCulloch
authors: Sonya M
authors: SM
authors: Schuh-Huerta
authors: Barbara
authors: B
authors: Sternfeld
authors: Renee A
authors: RA
authors: Reijo-Pera
authors: Marcelle I
authors: MI
authors: Cedars
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D054304:Anti-Mullerian Hormone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility / Q000502:physiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology*; D006080:Ovarian Follicle / Q000166:cytology / Q000502:physiology*; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone