title: Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines.
abstract: Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.
authors: Bioengineering Program & Department of Industrial and Manufacturing Engineering, Wichita State University, 1845 Fairmount Street, Wichita, KS 67260, USA.
authors: Anil
authors: A
authors: Mahapatro
authors: Dinesh K
authors: DK
authors: Singh
mesh_terms: D048271:Chitosan / Q000737:chemistry; D003487:Cyanoacrylates / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy; D010316:Particle Size; D014677:Pharmaceutical Vehicles / Q000138:chemical synthesis*; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D003487:Cyanoacrylates; D053769:Nanocapsules; D014677:Pharmaceutical Vehicles; D011091:Polyesters; D011108:Polymers; D014612:Vaccines; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; C029932:poly(methyl cyanoacrylate); D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D005780:Gelatin; D048271:Chitosan