title: Scratching can reveal more than just an itch.
abstract: The simplest definition of obstetric cholestasis (OC) is 'sluggish or interrupted bile flow in pregnancy'. In affected women the normal flow of bile out of the liver is reduced and this leads to raised bile salts (also referred to as bile acids) in the blood. This, together with abnormal liver function tests and the symptom of itch, may result in a woman being diagnosed with the condition of OC. Yet OC cannot be classified as one single disease. It is more accurate to think of it as a clinical state where a pregnant woman presents with a specific collection of symptoms and blood results together. This can occur in the context of several disorders, such as hepatitis C infection, adverse drug reaction or acute fatty liver of pregnancy, or can occur as a diagnosis that is only caused by pregnancy. Regardless of the underlying cause, OC is a condition that has the potential threat of stillbirth and myriad variables all of which make it challenging for clinicians to know how to treat and manage it. In this article Jenny and Alice show what these variables are and why there may be a risk of stillbirth.
authors: Imperial College, London.
authors: Jenny
authors: J
authors: Chambers
authors: Alice
authors: A
authors: Tuson
mesh_terms: D001647:Bile Acids and Salts / Q000097:blood; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002779:Cholestasis / Q000175:diagnosis* / Q000188:drug therapy / Q000451:nursing*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008880:Midwifery / Q000379:methods*; D009733:Nursing Diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000451:nursing*; D011256:Pregnancy Outcome; D011537:Pruritus / Q000209:etiology; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid