title: Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.
abstract: The action of anti-inflammatory and anti-allergic drugs on the eicosanoid system is briefly reviewed. In addition to the aspirin-like drugs, which directly inhibit the cyclo-oxygenase enzymes, other drugs such as the glucocorticoids and the cromones also inhibit the formation of eicosanoids. In the latter cases this is bought about through the release of a protein factor that acts through formyl peptide receptors on the target cell surface. Of growing interest, is the observation that this receptor is also a target for other eicosanoids, such as lipoxins and resolvins that modulate host defence systems.
authors: Centre for Biochemical Pharmacology, The William Harvey Research Institute, St Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.
authors: Samia
authors: S
authors: Yazid
authors: Lucy V
authors: LV
authors: Norling
authors: Rod J
authors: RJ
authors: Flower
mesh_terms: D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D015777:Eicosanoids / Q000378:metabolism*; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism*; D044042:Receptors, Formyl Peptide / Q000378:metabolism*
chemical_list: D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D015777:Eicosanoids; D005938:Glucocorticoids; D044042:Receptors, Formyl Peptide