title: [Modified peroxiredoxins as prototypes of drugs a powerful antioxidant].
abstract: The possibility of using modified peroxyredoxins as powerful antioxidant agents has been considered. Peroxyredoxins immobilized on perfluorocarbon emulsions and PTD-modified peroxyredoxins have been studied. It has been shown that peroxyredoxins efficiently bind to particles of perfluorocarbon emulsions, while maintaining their antioxidant properties. A panel of PTD-modified peroxyredoxins has been created and peroxyredoxins most effective both in antioxidant properties and the ability to penetrate cells have been selected. The modified peroxyredoxins obtained may serve as the basis for the design of drug with powerful antioxidant action.
authors: V I
authors: VI
authors: Novoselov
authors: V K
authors: VK
authors: Ravin
authors: M G
authors: MG
authors: Sharapov
authors: A D
authors: AD
authors: Sofin
authors: N I
authors: NI
authors: Kukushkin
authors: E E
authors: EE
authors: Fesenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002460:Cell Line; D057846:Cell-Penetrating Peptides / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000008:administration & dosage; D005466:Fluorocarbons / Q000008:administration & dosage; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D054464:Peroxiredoxins / Q000008:administration & dosage / Q000737:chemistry; D011993:Recombinant Fusion Proteins
chemical_list: D000975:Antioxidants; D057846:Cell-Penetrating Peptides; D004655:Emulsions; D005466:Fluorocarbons; D005609:Free Radicals; D011993:Recombinant Fusion Proteins; D054464:Peroxiredoxins; D010100:Oxygen