title: Small G proteins and their regulators in cellular signalling.
abstract: Small molecular weight GTPases (small G proteins) are essential in the transduction of signals from different plasma membrane receptors. Due to their endogenous GTP-hydrolyzing activity, these proteins function as time-dependent biological switches controlling diverse cellular functions including cell shape and migration, cell proliferation, gene transcription, vesicular transport and membrane-trafficking. This review focuses on endocrine diseases linked to small G proteins. We provide examples for the regulation of the activity of small G proteins by various mechanisms such as posttranslational modifications, guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs). Finally we summarize endocrine diseases where small G proteins or their regulatory proteins have been revealed as the cause.
authors: Department of Physiology, Semmelweis University, Tűzoltó u. 37-47, 1094 Budapest, Hungary.
authors: Roland
authors: R
authors: Csépányi-Kömi
authors: Magdolna
authors: M
authors: Lévay
authors: Erzsébet
authors: E
authors: Ligeti
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D048430:Cell Shape / Q000235:genetics; D004700:Endocrine System Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000235:genetics; D015398:Signal Transduction; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D020559:Monomeric GTP-Binding Proteins