title: Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.
abstract: AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.
authors: Ameeruddin Nusrath
authors: AN
authors: Unissa
authors: Subramanian
authors: S
authors: Sudha
authors: Nagamiah
authors: N
authors: Selvakumar
authors: Sameer
authors: S
authors: Hassan