title: Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases.
abstract: The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy. The Val/Val genotype tended to show elevated alanine aminotransferase levels (odds ratio=3.5; P=0.056). In addition, an elevated γ-glutamyltransferase level was associated with the Val/Val genotype (odds ratio=3.1; P=0.022). The SOD2 Val/Val genotype may therefore contribute to a valproic acid-induced elevation in the serum aminotransferase levels.
authors: Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. junsaru@gpo.kumamoto-u.ac.jp
authors: Junji
authors: J
authors: Saruwatari
authors: Mariko
authors: M
authors: Deguchi
authors: Yuki
authors: Y
authors: Yoshimori
authors: Madoka
authors: M
authors: Noai
authors: Shiho
authors: S
authors: Yoshida
authors: Naoki
authors: N
authors: Ogusu
authors: Kentaro
authors: K
authors: Oniki
authors: Shuichi
authors: S
authors: Yoshida
authors: Norio
authors: N
authors: Yasui-Furukori
authors: Sunao
authors: S
authors: Kaneko
authors: Takateru
authors: T
authors: Ishitsu
authors: Kazuko
authors: K
authors: Nakagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000409:Alanine / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D000637:Transaminases / Q000097:blood*; D014633:Valine / Q000235:genetics*; D014635:Valproic Acid / Q000627:therapeutic use*; D055815:Young Adult; D000099156:Superoxide Dismutase 2
chemical_list: D000409:Alanine; D013482:Superoxide Dismutase; D000637:Transaminases; D014633:Valine; D014635:Valproic Acid; D000099156:Superoxide Dismutase 2