title: Cardiorespiratory response to exercise testing in individuals with Alzheimer's disease.
abstract: OBJECTIVE
  To examine exercise testing response in Alzheimer's disease (AD) and possible disease-related change over time.
  
  
  METHODS
  Retrospective assessment of a 2-year observational study.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  Individuals without dementia (n=50) and with AD (n=31).
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Participants underwent a clinical dementia evaluation and performed an incremental exercise test using a treadmill and the modified Bruce protocol at baseline and at a 2-year follow-up. We examined oxygen consumption, minute ventilation, heart rate, and ventilatory equivalents for oxygen and carbon dioxide at submaximal and peak exercise intensities to determine whether the measures were different between groups or over time.
  
  
  RESULTS
  Participants with AD and those without dementia performed similarly at submaximal effort, and both groups showed similar changes in exercise response over 2 years. However, nondemented individuals had consistently higher values of oxygen consumption (P≤.02) and minute ventilation at peak effort at baseline (P=.003).
  
  
  CONCLUSIONS
  Individuals with AD demonstrate physiologic responses to submaximal exercise effort that are not significantly different than individuals without dementia. However, differences are apparent at the extreme of effort.
authors: Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, USA.
authors: Sandra A
authors: SA
authors: Billinger
authors: Eric D
authors: ED
authors: Vidoni
authors: Robyn A
authors: RA
authors: Honea
authors: Jeffrey M
authors: JM
authors: Burns
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010809:Physical Fitness / Q000502:physiology*; D012119:Respiration; D012189:Retrospective Studies