title: Dual modality drainage for symptomatic walled-off pancreatic necrosis reduces length of hospitalization, radiological procedures, and number of endoscopies compared to standard percutaneous drainage.
abstract: BACKGROUND
  Symptomatic walled-off pancreatic necrosis (WOPN) treated with dual modality endoscopic and percutaneous drainage (DMD) has been shown to decrease length of hospitalization (LOH) and use of radiological resources in comparison to standard percutaneous drainage (SPD).
  
  
  OBJECTIVE
  The aim of this study is to demonstrate that as the cohort of DMD and SPD patients expand, the original conclusions are durable.
  
  
  METHODS
  The database of patients receiving treatment for WOPN between January 2006 and April 2011 was analyzed retrospectively.
  
  
  METHODS
  One hundred two patients with symptomatic WOPN who had no previous drainage procedures were evaluated: 49 with DMD and 46 with SPD; 7 were excluded due to a salvage procedure.
  
  
  RESULTS
  Patient characteristics including age, sex, etiology of pancreatitis, and severity of disease based on computed tomographic severity index were indistinguishable between the two cohorts. The DMD cohort had shorter LOH, time until removal of percutaneous drains, fewer CT scans, drain studies, and endoscopic retrograde cholangiopancreatography (ERCPs; p < 0.05 for all). There were 12 identifiable complications during DMD, which were successfully treated without the need for surgery. The 30-day mortality in DMD was 4% (one multi-system organ failure and one out of the hospital with congestive heart failure). Three patients receiving SPD had surgery, and three (7%) died in the hospital.
  
  
  CONCLUSIONS
  DMD for symptomatic WOPN reduces LOH, radiological procedures, and number of ERCPs compared to SPD.
authors: The Digestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave., C3-GAS, Seattle, WA 98101, USA. michael.gluck@vmmc.org
authors: Michael
authors: M
authors: Gluck
authors: Andrew
authors: A
authors: Ross
authors: Shayan
authors: S
authors: Irani
authors: Otto
authors: O
authors: Lin
authors: S Ian
authors: SI
authors: Gan
authors: Mehran
authors: M
authors: Fotoohi
authors: Ellen
authors: E
authors: Hauptmann
authors: Robert
authors: R
authors: Crane
authors: Justin
authors: J
authors: Siegal
authors: David H
authors: DH
authors: Robinson
authors: L W
authors: LW
authors: Traverso
authors: Richard A
authors: RA
authors: Kozarek
mesh_terms: D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000706:statistics & numerical data; D003131:Combined Modality Therapy; D004322:Drainage / Q000379:methods* / Q000401:mortality; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000209:etiology; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data; D016896:Treatment Outcome