title: Reactivity and stability of dinuclear Pd(I) complexes: studies on the active catalytic species, insights into precatalyst activation and deactivation, and application in highly selective cross-coupling reactions.
abstract: The catalysis derived from the dinuclear Pd(I)-Pd(I) complex, {[PtBu(3)]PdBr}(2), has been studied with experimental, computational, and spectroscopic techniques. Experimental selectivity studies were performed, and the reactivity was subsequently investigated with density functional theory (B3LYP-D and M06L) to deduce information on the likely active catalytic species. The reactivity with aryl chlorides and bromides was found to be inconsistent with direct catalytic involvement of the Pd(I) dimer but consistent with mononuclear Pd(0) catalysis. Computational studies suggest that precatalyst transformation to the active catalytic species does not proceed via a direct disproportionation mechanism; a reductive pathway is the most likely scenario instead. Through (31)P NMR investigations it was identified that the combination of ArB(OH)(2), KF, and water triggers the conversion of the precatalyst to Pd(PtBu(3))(2) and, most likely, Pd-black as a competing side process, explaining the incomplete conversions of aryl chlorides in Suzuki cross-coupling reactions under Pd(I) dimer conditions. New applications in highly regio- and chemoselective transformations in short reaction times at room temperature are also demonstrated.
authors: Laboratory for Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors: Fabien
authors: F
authors: Proutiere
authors: Marialuisa
authors: M
authors: Aufiero
authors: Franziska
authors: F
authors: Schoenebeck