title: Synthesis, transport and incorporation into the nuclear envelope of A-type lamins and inner nuclear membrane proteins.
abstract: The mammalian NE (nuclear envelope), which separates the nucleus from the cytoplasm, is a complex structure composed of nuclear pore complexes, the outer and inner nuclear membranes, the perinuclear space and the nuclear lamina (A- and B-type lamins). The NE is completely disassembled and reassembled at each cell division. In the present paper, we review recent advances in the understanding of the mechanisms implicated in the transport of inner nuclear membrane and nuclear lamina proteins from the endoplasmic reticulum to the nucleus in interphase cells and mitosis, with special attention to A-type lamins.
authors: Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro 3, 28029 Madrid, Spain. jmagonzalez@cnic.es
authors: Jose M
authors: JM
authors: González
authors: Vicente
authors: V
authors: Andrés
mesh_terms: D000818:Animals; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis*; D008938:Mitosis; D009685:Nuclear Envelope / Q000378:metabolism*; D009687:Nuclear Proteins / Q000096:biosynthesis*; D021381:Protein Transport
chemical_list: D034904:Lamin Type A; D008565:Membrane Proteins; D009687:Nuclear Proteins