title: Diagnostic value of ischaemia-modified albumin in pulmonary contusion in rats.
abstract: BACKGROUND
  Patients with pulmonary contusion (PC) are at increased risk of development of complications and death after trauma. The early diagnosis and determination of severity of PC could improve clinical outcomes. The aim of the study was to determine the diagnostic value of ischaemia-modified albumin (IMA) in a PC model in rats.
  
  
  METHODS
  Thirty-two Sprague-Dawley rats were randomly allocated to four groups; the uninjured control Group I (n=7) and the uninjured control Group II (n=7) were euthanised at 2 and 6h, respectively, and PC groups III (n=9) and IV (n=9) were euthanised at 2 and 6h after trauma, respectively. The serum level of IMA, tissue and serum malondialdehyde (MDA) levels, and histopathological damage scores of the lung tissue were determined.
  
  
  RESULTS
  Serum IMA and lung tissue MDA levels in the PC groups were not significantly different to those of the control groups (p=0.555; p=0.086, respectively). Serum MDA levels were significantly higher in the PC groups than in the control groups (p=0.011). When histopathological changes in lung parenchyma were evaluated, there was a statistical difference between the injured and uninjured groups for inflammation and lung injury (p=0.017; p=0.001, respectively). However, there was no significant correlation between the histopathological score and biochemical parameters.
  
  
  CONCLUSIONS
  Our preliminary findings suggest that there is no significant change of serum IMA levels in the acute phase of PC induced by blunt chest trauma.
authors: Department of Thoracic Surgery, Faculty of Medicine, 19 Mayis University, Samsun, Turkey. cburcin@hotmail.com
authors: Burcin
authors: B
authors: Celik
authors: Turker
authors: T
authors: Yardan
authors: Mehmet
authors: M
authors: Kefeli
authors: Ahmet
authors: A
authors: Mentese
authors: Suleyman
authors: S
authors: Turedi
authors: Ahmet
authors: A
authors: Baydin
authors: Suleyman Caner
authors: SC
authors: Karahan
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D007511:Ischemia / Q000097:blood* / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism*; D014949:Wounds, Nonpenetrating / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D008315:Malondialdehyde