title: Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones.
abstract: Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents.
authors: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr
authors: Chung-Kyu
authors: CK
authors: Ryu
authors: Joo Hee
authors: JH
authors: Yoon
authors: Ae Li
authors: AL
authors: Song
authors: Hyun Ah
authors: HA
authors: Im
authors: Ji Young
authors: JY
authors: Kim
authors: Aram
authors: A
authors: Kim
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000378:metabolism; D001234:Aspergillus niger / Q000378:metabolism; D002176:Candida albicans / Q000378:metabolism; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D007211:Indoles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D002243:Carbolines; D007211:Indoles; C573854:benzo(f)pyrido(1,2-a)indole-6,11-dione; C573853:pyrido(1,2-a)indole-1,4-dione