title: What can be seen by 18F-FDG PET in atherosclerosis imaging? The effect of foam cell formation on 18F-FDG uptake to macrophages in vitro.
abstract: (18)F-FDG PET is a promising tool for detecting vulnerable plaques, depending on the extent of macrophage infiltration; however, it is still not clear which stage of the lesion can be detected by (18)F-FDG PET.
  
  
  METHODS
  In this study, we investigated the effect of foam cell formation on (18)F-FDG uptake using cultured mouse peritoneal macrophages.
  
  
  RESULTS
  (18)F-FDG accumulation was increased by foam cell formation, but the uptake was decreased to the control level after complete differentiation to foam cells. Changes in hexokinase activity tended to accompany changes in (18)F-FDG uptake. In contrast, changes in glucose-6-phosphatase activity and glucose transporter 1 expression did not parallel (18)F-FDG uptake.
  
  
  CONCLUSIONS
  Our results suggest that (18)F-FDG PET detects the early stage of foam cell formation in atherosclerosis.
authors: Medical Photonics Research Center, Hamamatsu, Japan. mogawa@hama-med.ac.jp
authors: Mikako
authors: M
authors: Ogawa
authors: Satoki
authors: S
authors: Nakamura
authors: Yuriko
authors: Y
authors: Saito
authors: Mutsumi
authors: M
authors: Kosugi
authors: Yasuhiro
authors: Y
authors: Magata
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001692:Biological Transport; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D005487:Foam Cells / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D051379:Mice; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography
chemical_list: D051272:Glucose Transporter Type 1; D019788:Fluorodeoxyglucose F18; D006593:Hexokinase; D005952:Glucose-6-Phosphatase