title: A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors.
abstract: OBJECTIVE
  Few studies have examined the dietary habits of ovarian cancer survivors. Therefore, we conducted a study to assess the feasibility and impact of two dietary interventions for ovarian cancer survivors.
  
  
  METHODS
  In this randomized, parallel-group study, 51 women (mean age, 53 years) diagnosed with stages II-IV ovarian cancer were recruited and randomly assigned to a low fat, high fiber (LFHF) diet or a modified National Cancer Institute diet supplemented with a soy-based beverage and encapsulated fruit and vegetable juice concentrates (FVJCs). Changes in clinical measures, serum carotenoid and tocopherol levels, dietary intake, anthropometry, and health-related quality of life (HRQOL) were assessed with paired t-tests.
  
  
  RESULTS
  The recruitment rate was 25%, and the retention rate was 75% at 6 months. At baseline, 28% and 45% of women met guidelines for intake of fiber and of fruits and vegetables, respectively. After 6 months, total serum carotenoid levels and α- and β-carotene concentrations were significantly increased in both groups (P<0.01); however, β-carotene concentrations were increased more in the FVJC group. Serum β-cryptoxanthin levels, fiber intake (+5.2g/day), and daily servings of juice (+0.9 servings/day) and vegetables (+1.3 servings/day) were all significantly increased in the LFHF group (all P<0.05). Serum levels of albumin, lutein and zeaxanthin, retinol, and retinyl palmitate were significantly increased in the FVJC group (all P<0.05). No changes in cancer antigen-125, anthropometry, or HRQOL were observed.
  
  
  CONCLUSIONS
  Overall, this study supports the feasibility of designing dietary interventions for stages II-IV ovarian cancer survivors and provides preliminary evidence that a low fat high fiber diet and a diet supplemented with encapsulated FVJC may increase phytonutrients in ovarian cancer survivors.
authors: Dorothy I. Height Center for Health Equity and Evaluation Research, University of Houston and University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. rjpaxton@mdanderson.org
authors: Raheem J
authors: RJ
authors: Paxton
authors: Celia
authors: C
authors: Garcia-Prieto
authors: Maria
authors: M
authors: Berglund
authors: Mike
authors: M
authors: Hernandez
authors: Richard A
authors: RA
authors: Hajek
authors: Beverly
authors: B
authors: Handy
authors: Jubilee
authors: J
authors: Brown
authors: Lovell A
authors: LA
authors: Jones
mesh_terms: D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D002338:Carotenoids / Q000097:blood; D003376:Counseling; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D005638:Fruit; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D017741:Survivors; D014675:Vegetables; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D018394:CA-125 Antigen; D004043:Dietary Fiber; D002338:Carotenoids; D024502:alpha-Tocopherol