title: [Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Molecular mechanism in cardiac valve calcification].
abstract: When cardiac valve stenosis is accompanied by calcification, symptoms and prognosis become much worse and may cause sudden cardiac death. The prevalence of this disease has increased with the rapidly aging in Japanese society. It has recently been revealed that several genes which relate to physiological ossification and calcification play important roles in this process. To find a suitable target for medical treatment, the molecular mechanism for calcification of cardiac valves should be elucidated in detail. In this review, we summarize the current knowledge on the pathology and molecular mechanism for ectopic calcification of the cardiac valve.
authors: Department of Pharmacology, Hirosaki University Graduate School of Medicine, Japan.
authors: Ken-Ichi
authors: K
authors: Furukawa
authors: Shigeru
authors: S
authors: Motomura
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000473:pathology; D055396:Bone Morphogenetic Protein 2 / Q000502:physiology; D002114:Calcinosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000502:physiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006349:Heart Valve Diseases / Q000150:complications / Q000235:genetics* / Q000473:pathology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D000097568:Matrix Gla Protein
chemical_list: D000469:Alkaline Phosphatase; D055396:Bone Morphogenetic Protein 2; D002135:Calcium-Binding Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D016326:Extracellular Matrix Proteins; D018398:Homeodomain Proteins; D016328:NF-kappa B; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D000097568:Matrix Gla Protein; C525718:BMP2 protein, human; C100596:DLX5 protein, human