title: Removal torque analysis of implants in rabbit tibia after topical application of simvastatin gel.
abstract: The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P < .05). Groups IG-28, I-28, and I-56 showed similar values (P > .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.
authors: 1  Paulista University (UNIP), São Paulo, SP, Brazil.
authors: Fatima Neves
authors: FN
authors: Faraco-Schwed
authors: Luiz Macedo
authors: LM
authors: Mangueira
authors: Joao Vitor Albuquerque
authors: JV
authors: Ribeiro
authors: Alexsandro Da Silva
authors: Ada S
authors: Antao
authors: Jamil Awad
authors: JA
authors: Shibli
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000287:Administration, Topical; D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D017267:Dental Prosthesis Design; D020878:Device Removal; D005782:Gels; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D019821:Simvastatin / Q000008:administration & dosage / Q000494:pharmacology*; D013499:Surface Properties; D013977:Tibia / Q000187:drug effects / Q000601:surgery*; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D019415:Torque
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D003764:Dental Materials; D005782:Gels; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D014025:Titanium