title: Molecular characterization of newly emerged blaKPC-2-producing Klebsiella pneumoniae in Singapore.
abstract: In Asia, bla(KPC) detection has been limited to East Asia and not yet seen in Southeast Asia. We report four bla(KPC-2)-containing Klebsiella pneumoniae isolates from two different hospitals in Singapore. All isolates belonged to strain type 11 (ST11) and were indistinguishable by pulsed-field gel electrophoresis (PFGE). bla(KPC-2) was located on nonconjugative plasmids and flanked by mobile genetic structures composed of a partial Tn4401 transposon and a Tn3-based transposon which previously have been described only in Chinese isolates.
authors: Department of Laboratory Medicine, National University Hospital, Singapore. Michelle_Balm@nuhs.edu.sg
authors: Michelle N D
authors: MN
authors: Balm
authors: Grace
authors: G
authors: Ngan
authors: Roland
authors: R
authors: Jureen
authors: Raymond T P
authors: RT
authors: Lin
authors: Jeanette
authors: J
authors: Teo
mesh_terms: D016000:Cluster Analysis; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D058889:Molecular Typing; D010957:Plasmids; D012846:Singapore; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae