title: Body mass index change in adulthood and lung and upper aerodigestive tract cancers.
abstract: Body mass index (BMI) has been inversely associated with lung and upper aerodigestive tract (UADT) cancers. However, only a few studies have assessed BMI change in adulthood in relation to cancer. To understand the relationship between BMI change and these cancers in both men and women, we analyzed data from a population-based case-control study conducted in Los Angeles County. Adulthood BMI change was measured as the proportional change in BMI between age 21 and 1 year before interview or diagnosis. Five categories of BMI change were included, and individuals with no more than a 5% loss or gain were defined as having a stable BMI (reference group). Adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using logistic regression models. Potential confounders included age, gender, ethnicity, education, tobacco smoking and energy intake. For UADT cancers, we also adjusted for alcohol drinking status and frequency. A BMI gain of 25% or higher in adulthood was inversely associated with lung cancer (OR 0.53, 95% CI 0.33-0.84) and UADT cancers (OR 0.44, 95% CI 0.27-0.71). In subgroup analyses, a BMI gain of ≥25% was inversely associated with lung and UADT cancers among current and former smokers, as well as among current and former alcohol drinkers. The inverse association persisted among moderate and heavy smokers (≥20 pack-years). The observed inverse associations between adulthood BMI gain and lung and UADT cancers indicate a potential role for body weight-related biological pathways in the development of lung and UADT cancers.
authors: Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095-1772, USA.
authors: Heather P
authors: HP
authors: Tarleton
authors: Sungshim Lani
authors: SL
authors: Park
authors: Wei-Ming
authors: WM
authors: Zhu
authors: Yuan-Chin Amy
authors: YC
authors: Lee
authors: Mia
authors: M
authors: Hashibe
authors: Hal
authors: H
authors: Morgenstern
authors: Donald P
authors: DP
authors: Tashkin
authors: Jenny T
authors: JT
authors: Mao
authors: Wendy
authors: W
authors: Cozen
authors: Thomas M
authors: TM
authors: Mack
authors: Zuo-Feng
authors: ZF
authors: Zhang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged