title: [Lung diffusion capacity and quality of life 6 months after discharge from the ICU among survivors of acute respiratory distress syndrome due to influenza A H1N1].
abstract: OBJECTIVE
  An evaluation is made of lung function and quality of life 6 months after discharge from the Intensive Care Unit (ICU) among survivors of acute respiratory distress syndrome (ARDS) due to pandemic 2009 influenza A H1N1, based on studies of lung function and the EQ-5D health questionnaire.
  
  
  METHODS
  Case series.
  
  
  METHODS
  The ICU of Dr. Leónidas Lucero Acute Cases Municipal Hospital, Bahía Blanca, Argentina.
  
  
  METHODS
  PATIENTS discharged from the ICU who had been admitted with ARDS in 2009 due to influenza A H1N1.
  
  
  RESULTS
  Eleven patients were studied. Seven were positive for influenza H1N1 and four were negative. The mean age was 37±9.5 years, and 73% were males. Quality of life, as measured by the EQ-5D, showed changes in the 5 components in all patients, particularly in the pain/discomfort dimension 1.55±0.52; health status (EQ%health) was 70%±24. The indices adjusted for Argentina were Time Trade Off (TTO) 0.903±0.085 and Visual Analog Scale (VAS) 0.827±0.153. In all patients, spirometry and the study of pulmonary diffusion (DLCO) showed values of >80%. There was no correlation between lung diffusion and quality of life (%DLCO and EQ%health). A correlation was observed between quality of life and TTO (EQ%health and TTO), and between quality of life and the VAS score (EQ%health and VAS).
  
  
  CONCLUSIONS
  Although the sample is small, our results suggest that patients with ARDS due to influenza A H1N1 evaluated 6 months after discharge from the ICU show no deterioration of lung function, and the impact on quality of life is moderate-in contrast to the situation found in patients with ARDS of other etiologies.
authors: Unidad de Cuidados Intensivos, Hospital Municipal de Agudos Dr. Leónidas Lucero, Bahía Blanca, Argentina. qladolfo@hotmail.com, aquispelaime@uns.edu.ar
authors: A M
authors: AM
authors: Quispe-Laime
authors: C
authors: C
authors: Fiore
authors: M N
authors: MN
authors: González-Ros
authors: J E
authors: JE
authors: Bettini
authors: V E
authors: VE
authors: Rolfo
authors: C G
authors: CG
authors: Campagne
authors: P A
authors: PA
authors: Barberio
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D001118:Argentina / Q000453:epidemiology; D003289:Convalescence / Q000523:psychology*; D003863:Depression / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications*; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000453:epidemiology; D010147:Pain Measurement; D011653:Pulmonary Diffusing Capacity; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D012720:Severity of Illness Index; D017741:Survivors / Q000523:psychology*