title: Impaired glutamatergic and GABAergic function at early age in AβPPswe-PS1dE9 mice: implications for Alzheimer's disease.
abstract: Preclinical diagnosis of Alzheimer's disease is a major challenge. The present study evaluates glutamatergic and GABAergic neurotransmitter energetics at the age of 6 months in AβPPswe-PS1dE9 mouse model of Alzheimer's disease by using (1)H-[(13)C]-NMR spectroscopy together with infusion of [1,6-(13)C(2)]glucose. NMR analysis suggested no significant derangement in neurochemical profile in AβPPswe-PS1dE9 mice. However, decrease in labeling of glutamate-C4, GABA-C2 and glutamine-C4 at early infusion-time together with no change in labeling at steady state from [1,6-(13)C(2)]glucose indicates an impaired glutamatergic and GABAergic glucose oxidation and neurotransmitter cycle in AβPPswe-PS1dE9 mice. These findings may have implication in preclinical diagnosis of Alzheimer's disease.
authors: NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.
authors: Vivek
authors: V
authors: Tiwari
authors: Anant B
authors: AB
authors: Patel
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D018698:Glutamic Acid / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000235:genetics / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D016564:Amyloid beta-Protein Precursor; D053764:Presenilin-1; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid