title: Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans.
abstract: To investigate the relationship between plasma reactive oxygen species (ROS) levels and severity of age-related hearing impairment in humans. We recruited 302 adult subjects aged 40-77 years with normal or symmetrical sensorineural hearing loss. The association of plasma ROS levels on pure tone average of low frequencies (PTA-low) and pure tone average of high frequencies (PTA-high) were analyzed. Luminol-dependent chemiluminescence signals, which reflect hydrogen peroxide (H(2)O(2)), hypochlorite (HOCl/OCl(-)) and hydroxyl radicals (•OH) levels, showed significant positive association with PTA-low and PTA-high after adjusting for age, gender, central obesity, systemic diseases, and health-related habits (smoking, drinking, antioxidant intake). Lucigenin-dependent chemiluminescence signals, which mainly reflect superoxide anion (O(2)•(-)) levels, showed significant positive association with PTA-low, but not with PTA-high after adjusting for other variables. We concluded that plasma ROS levels were associated with severity of age-related hearing impairment in humans. Various ROS may differently affect auditory dysfunctions.
authors: Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors: Juen-Haur
authors: JH
authors: Hwang
authors: Jin-Cherng
authors: JC
authors: Chen
authors: Chuan-Jen
authors: CJ
authors: Hsu
authors: Wei-Shiung
authors: WS
authors: Yang
authors: Tien-Chen
authors: TC
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000704:Analysis of Variance; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D001827:Body Height; D001835:Body Weight; D005260:Female; D034381:Hearing Loss / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D017665:Hydroxyl Radical / Q000097:blood; D006997:Hypochlorous Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D006861:Hydrogen Peroxide