title: Intake of alcohol and risk of adult-onset asthma.
abstract: OBJECTIVE
  To examine the association between intake of alcohol and risk of adult-onset asthma.
  
  
  METHODS
  Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry.
  
  
  RESULTS
  The eight-year incidence of asthma was 4.3%. After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p = 0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR = 1.59 (1.25-2.02), p = 0.000, whereas the risk of asthma in heavy daily drinkers (≥4 units/day) was also increased, however not statistically significant, OR = 1.13 (0.54-2.36), p = 0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3%) compared with beer preference (4.3%) or no preference (4.4%). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR = 0.87 (0.51-1.46), p = 0.590.
  
  
  CONCLUSIONS
  Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma.
authors: Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
authors: Sofie
authors: S
authors: Lieberoth
authors: Vibeke
authors: V
authors: Backer
authors: Kirsten Ohm
authors: KO
authors: Kyvik
authors: Lars Rauff
authors: LR
authors: Skadhauge
authors: Janne Schurmann
authors: JS
authors: Tolstrup
authors: Morten
authors: M
authors: Grønbæk
authors: Allan
authors: A
authors: Linneberg
authors: Simon Francis
authors: SF
authors: Thomsen
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology*; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D001515:Beer; D015992:Body Mass Index; D002648:Child; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014920:Wine; D055815:Young Adult