title: Investigation of the inclusion behavior of chlorogenic acid with hydroxypropyl-β-cyclodextrin.
abstract: The inclusion complexation behavior of chlorogenic acid (CGA) with the hydroxypropyl-β-cyclodextrin (HP-β-CD) was investigated in both solution and the solid state by UV-vis and fluorescence spectroscopy, infrared spectroscopy (IR), NMR spectroscopy as well as differential scanning calorimetry (DSC). The experimental results indicate that CGA is able to form an inclusion complex with HP-β-CD. The inclusion complex has a stoichiometry of 1:1 and the formation constant was calculated to be 155.7 M(-1). The antioxidant activity of CGA on complexation with HP-β-CD increased as compared to uncomplexed CGA. NMR spectroscopic studies show that the aromatic ring and the vinyl group of CGA are deeply included inside the CD cavity.
authors: Research Institute of Applied Chemistry, Shanxi University, Taiyuan, PR China. chao@sxu.edu.cn
authors: Jianbin
authors: J
authors: Chao
authors: Hongfang
authors: H
authors: Wang
authors: Wei
authors: W
authors: Zhao
authors: Min
authors: M
authors: Zhang
authors: Liwei
authors: L
authors: Zhang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000975:Antioxidants / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002726:Chlorogenic Acid / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D010851:Picrates / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002726:Chlorogenic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl