title: The rapid efficacy of abatacept in a patient with rheumatoid vasculitis.
abstract: We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept.
authors: Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
authors: Wataru
authors: W
authors: Fujii
authors: Masataka
authors: M
authors: Kohno
authors: Hidetaka
authors: H
authors: Ishino
authors: Amane
authors: A
authors: Nakabayashi
authors: Kazuki
authors: K
authors: Fujioka
authors: Takashi
authors: T
authors: Kida
authors: Hidetake
authors: H
authors: Nagahara
authors: Ken
authors: K
authors: Murakami
authors: Kaoru
authors: K
authors: Nakamura
authors: Takahiro
authors: T
authors: Seno
authors: Aihiro
authors: A
authors: Yamamoto
authors: Yutaka
authors: Y
authors: Kawahito
mesh_terms: D000069594:Abatacept; D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D057915:Drug Substitution; D005260:Female; D005938:Glucocorticoids; D006304:Health Status; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use; D010956:Plasmapheresis; D012074:Remission Induction; D056653:Rheumatoid Vasculitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D017211:Treatment Failure; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D018796:Immunoconjugates; D014409:Tumor Necrosis Factor-alpha; D000069594:Abatacept; D008727:Methotrexate