title: miRNA processing and human cancer: DICER1 cuts the mustard.
abstract: Numerous studies have implicated microRNAs (miRNAs) in cancer initiation and progression. In contrast, only recently has attention been focused on the pathway that generates these regulatory molecules. The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA processing pathway. Deciphering of the many links between miRNA processing perturbations and cancer will likely provide insights into mechanisms of cancer control.
authors: Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec H2W 1S6, Canada.
authors: Amin
authors: A
authors: Bahubeshi
authors: Marc
authors: M
authors: Tischkowitz
authors: William D
authors: WD
authors: Foulkes
mesh_terms: D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D057895:Haploinsufficiency / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D043244:Ribonuclease III / Q000378:metabolism*; D057170:Translational Research, Biomedical
chemical_list: D035683:MicroRNAs; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases