title: Safety and clinical usage of newcastle disease virus in cancer therapy.
abstract: Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, especially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV strains applied for cancer immunotherapy is also discussed in this paper.
authors: Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Han Yuen
authors: HY
authors: Lam
authors: Swee Keong
authors: SK
authors: Yeap
authors: Mehdi R
authors: MR
authors: Pirozyan
authors: Abdul Rahman
authors: AR
authors: Omar
authors: Khatijah
authors: K
authors: Yusoff
authors: Abd Aziz
authors: AA
authors: Suraini
authors: Suraini
authors: Abd-Aziz
authors: Noorjahan Banu
authors: NB
authors: Alitheen
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology*; D045744:Cell Line, Tumor; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D009522:Newcastle disease virus / Q000235:genetics / Q000276:immunology*; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses / Q000235:genetics / Q000276:immunology*; D012449:Safety
chemical_list: D019496:Cancer Vaccines