title: Occidiofungin's chemical stability and in vitro potency against Candida species.
abstract: Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.
authors: Department of Biological Sciences, Mississippi State University, Mississippi State, Mississippi, USA.
authors: Dayna
authors: D
authors: Ellis
authors: Jiten
authors: J
authors: Gosai
authors: Charles
authors: C
authors: Emrick
authors: Rachel
authors: R
authors: Heintz
authors: Lanette
authors: L
authors: Romans
authors: Donna
authors: D
authors: Gordon
authors: Shi-En
authors: SE
authors: Lu
authors: Frank
authors: F
authors: Austin
authors: Leif
authors: L
authors: Smith
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D019117:Burkholderia / Q000378:metabolism; D002175:Candida / Q000145:classification* / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D055666:Lipopeptides / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000592:standards; D010447:Peptide Hydrolases / Q000378:metabolism; D013696:Temperature
chemical_list: D000935:Antifungal Agents; D055666:Lipopeptides; D010447:Peptide Hydrolases