title: Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model.
abstract: The present study was undertaken to observe the inhibition of angiogenesis by decursin. It was the first time to show that decursin offered strong anti-angiogenic activities under the biologically relevant growth (with serum) conditions. Decursin significantly inhibited human umbilical vein endothelial cell (HUVEC) proliferation concomitant with G1 phase cell cycle arrest. Decursin also inhibited HUVEC-capillary tube formation and invasion/migration in a dose-dependant manner which was associated with the suppression of matrix metalloproteinase (MMP) -2 and -9 activities. Decursin suppressed angiogenesis in ex vivo rat aortic ring angiogenesis model where it significantly inhibited blood capillary-network sprouting from rat aortic sections. Taken together, these findings suggested anti-angiogenic activity of decursin in biologically relevant condition, and warrants further pre-clinical studies for its potential clinical usefulness.
authors: Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
authors: Tariq A
authors: TA
authors: Bhat
authors: Jung S
authors: JS
authors: Moon
authors: Sookyeon
authors: S
authors: Lee
authors: Dongsool
authors: D
authors: Yim
authors: Rana P
authors: RP
authors: Singh
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D001578:Benzopyrans / Q000494:pharmacology*; D002087:Butyrates / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D023421:Models, Animal; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000201:enzymology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D051381:Rats
chemical_list: D020533:Angiogenesis Inhibitors; D001578:Benzopyrans; D002087:Butyrates; D061965:Matrix Metalloproteinase Inhibitors; C101278:decursin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9