title: Assembly of the presenilin γ-/ε-secretase complex.
abstract: The presenilin complex is composed of four core proteins (presenilin 1 or presenilin 2, APH1, nicastrin, and PEN2). Several endogenous proteins have been reported to selectively modulate the function of the presenilin complexes; these include transmembrane trafficking protein, 21-KD (TMP21), CD147 antigen (basigin), the γ-secretase-activating protein (gSAP), and the orphan G-protein-coupled receptor 3. Because the structure and assembly of these complexes underlies their activity, this review will discuss current work on the assembly of the complex and on presenilin-interacting proteins that regulate secretase activity.
authors: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.|Cambridge Institute for Medical Research, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
authors: P
authors: P
authors: St George-Hyslop
authors: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.|Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors: P E
authors: PE
authors: Fraser
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D010450:Endopeptidases; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D010447:Peptide Hydrolases / Q000737:chemistry / Q000502:physiology; D053764:Presenilin-1 / Q000737:chemistry* / Q000502:physiology; D053766:Presenilin-2 / Q000737:chemistry* / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C469349:PSENEN protein, human; D053764:Presenilin-1; D053766:Presenilin-2; C475154:APH1A protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases