title: Successful treatment of disseminated fusariosis with voriconazole in an acute lymphoblastic leukaemia patient.
abstract: Fusarium species are actually the second most common pathogenic mould in immunocompromised patients, and it is difficult to treat such fusarial infections with current antifungal agents. We report the case of a 53-year-old woman with Philadelphia-positive acute lymphoblastic leukaemia. During induction chemotherapy with febrile neutropenia, she developed a disseminated fusariosis, with persistent fever refractory to antibacterial agents and caspofungin (as empirical therapy), painful skin lesions and respiratory impairment. Fusarium solani was isolated from skin biopsy. Voriconazole was successfully implemented as antifungal curative therapy. During the second intensive chemotherapy no reactivation of fusariosis was detected.
authors: Centre de Lutte contre le cancer Henri Becquerel, Rouen, France.
authors: Aurelie
authors: A
authors: Labois
authors: Christian
authors: C
authors: Gray
authors: Stephane
authors: S
authors: Lepretre
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D060585:Fusariosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011743:Pyrimidines / Q000008:administration & dosage*; D013902:Radiography, Thoracic; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole