title: Progress and problems in muscle glycogenoses.
abstract: In this selective review, we consider a number of unsolved questions regarding the glycogen storage diseases (GSD). Thus, the pathogenesis of Pompe disease (GSD II) is not simply explained by excessive intralysosomal glycogen storage and may relate to a more general dysfunction of autophagy. It is not clear why debrancher deficiency (GSD III) causes fixed myopathy rather than exercise intolerance, unless this is due to the frequent accompanying neuropathy. The infantile neuromuscular presentation of branching enzyme deficiency (GSD IV) is underdiagnosed and is finally getting the attention it deserves. On the other hand, the late-onset variant of GSD IV (adult polyglucosan body disease APBD) is one of several polyglucosan disorders (including Lafora disease) due to different etiologies. We still do not understand the clinical heterogeneity of McArdle disease (GSD V) or the molecular basis of the rare fatal infantile form. Similarly, the multisystemic infantile presentation of phosphofructokinase deficiency (GSD VII) is a conundrum. We observed an interesting association between phosphoglycerate kinase deficiency (GSD IX) and juvenile Parkinsonism, which is probably causal rather than casual. Also unexplained is the frequent and apparently specific association of phosphoglycerate mutase deficiency (GSD X) and tubular aggregates. By paying more attention to problems than to progress, we aimed to look to the future rather than to the past.
authors: Department of Neurology, Columbia University Medical Center, New York, USA. sd12@columbia.edu
authors: S
authors: S
authors: DiMauro
authors: R
authors: R
authors: Spiegel
mesh_terms: D000328:Adult; D017668:Age of Onset; D001706:Biopsy; D050260:Carbohydrate Metabolism / Q000235:genetics*; D002648:Child; D018450:Disease Progression; D004568:Electrodiagnosis; D036262:Empirical Research; D036281:Genetic Research; D006008:Glycogen Storage Disease / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007223:Infant; D040582:Inheritance Patterns; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009130:Muscle, Smooth / Q000378:metabolism* / Q000473:pathology; D035703:Therapies, Investigational