title: Clinicopathological features of paediatric renal biopsies in Shanghai over a 31 year period.
abstract: OBJECTIVE
  To identify the variations in paediatric renal biopsy pathology and clinicopathological features during the past 31 years.
  
  
  METHODS
  A retrospective analysis of paediatric renal biopsies performed at a single institution in Shanghai from January 1979 to December 2009 was conducted.
  
  
  RESULTS
  The major pathologies included minor glomerular abnormalities (MGA, 26.1%), IgA nephropathy (IgAN, 17%) and mesangial proliferative glomerulonephritis (MsPGN) without IgA deposition (11.3%). The major clinical presentations included nephrotic syndrome (NS, 39.4%), haematuria with proteinuria (24.4%) and persistent microscopic haematuria (15.1%). MGA accounted for 46.9% of the cases in NS. IgAN and HSN accounted for 24% and 28.9% of patients with concomitant haematuria and proteinuria, and thin basement membrane nephropathy accounted for 51.2% of cases with persistent microscopic haematuria. The frequency of IgAN (78.6%) was much higher than that of TBMN (29.0%) in patients with persistent microscopic haematuria with abnormal urinary albumin.
  
  
  CONCLUSIONS
  Minor glomerular abnormalities and IgAN were the major renal diseases in our study population, and the focus of our paediatric nephrologists. The high proportion of TBMN suggested that there should be limited use of renal biopsy for patients with persistent microscopic haematuria and renal biopsy should be performed in the presence of proteinuria or abnormal levels of urinary albumin.
authors: Department of Nephrology and Rheumatism, Children's Hospital of Fudan University, Shanghai, China.
authors: Yibing
authors: Y
authors: Zheng
authors: Hong
authors: H
authors: Xu
authors: Lijun
authors: L
authors: Zhou
authors: Qi
authors: Q
authors: Cao
authors: Li
authors: L
authors: Sun
authors: Qian
authors: Q
authors: Shen
authors: Wei
authors: W
authors: Guo
authors: Xiaoyan
authors: X
authors: Fang
authors: Haimei
authors: H
authors: Liu
authors: Jun
authors: J
authors: Zhang
authors: Jia
authors: J
authors: Rao
authors: Jin
authors: J
authors: Chen
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005922:Glomerulonephritis, IGA / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D006417:Hematuria / Q000473:pathology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000473:pathology; D011507:Proteinuria / Q000473:pathology; D012189:Retrospective Studies