title: Physical characterisation and component release of poly(vinyl alcohol)-tetrahydroxyborate hydrogels and their applicability as potential topical drug delivery systems.
abstract: Poly(vinyl alcohol)-tetrahydroxyborate (PVA-THB) hydrogels are dilatant formulations with potential for topical wound management. To support this contention, the physical properties, rheological behaviour and component release of candidate formulations were investigated. Oscillatory rheometry and texture profile analysis were used at room temperature and 37 °C. Results showed that it was possible to control the rheological and textural properties by altering component concentration and modifying the type of PVA polymer used. Hydrogels made using PVA grades with higher degrees of hydrolysis displayed favourable characteristics from a wound healing perspective. In vitro release of borate and PVA were assessed in order to evaluate potential clinical dosing of free species originating from the hydrogel structure. Component diffusion was influenced by both concentration and molecular weight, where relevant, with up to 5% free PVA cumulative release observed after 30 min. The results of this study demonstrated the importance of poly(vinyl alcohol) selection for ensuring appropriate gel formation in PVA-THB hydrogels. The benefits of higher degrees of hydrolysis, in particular, included lower excipient release and reduced bioadhesion. The unique physical characteristics of these hydrogels make them an appealing delivery vehicle for chronic and acute wound management purposes.
authors: School of Pharmacy, Queen's University Belfast, Belfast, UK.
authors: Diarmaid J
authors: DJ
authors: Murphy
authors: Mayur G
authors: MG
authors: Sankalia
authors: Ryan G
authors: RG
authors: Loughlin
authors: Ryan F
authors: RF
authors: Donnelly
authors: Mark G
authors: MG
authors: Jenkins
authors: Paul A
authors: PA
authors: M C Carron
mesh_terms: D000268:Adhesiveness; D000287:Administration, Topical; D001881:Borates / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D020100:Hydrogels; D006868:Hydrolysis; D007700:Kinetics; D008970:Molecular Weight; D011142:Polyvinyl Alcohol / Q000008:administration & dosage / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D001881:Borates; D004337:Drug Carriers; D020100:Hydrogels; D011142:Polyvinyl Alcohol