title: [A case of rapidly progressive metastatic pulmonary amelanotic malignant melanoma 16 years after resection of melanoma].
abstract: An 80-year-old Japanese male was admitted to our hospital because of bloody sputum. He had a history of malignant melanoma of the left fourth digit, which was surgically excised 16 years previously. On hospital admission, chest computed tomography revealed several nodules in the lower lobes. He underwent thoracoscopic lung biopsy and amelanotic malignant melanoma was histologically diagnosed by immunohistochemical staining. The staining pattern with several antibodies was similar to that of the melanoma excised 16 years previously. Therefore, we concluded that the nodules in the lung were metastases of the malignant melanoma of the digit. Despite treatment with interferon, the nodules progressed rapidly, and the patient died 4 months later. This case suggests that the risk of recurrence with rapidly progressive distant metastasis should be considered in patients with malignant melanoma, even after a long disease-free interval. In addition, this case suggests that immunohistochemical stains with several antibodies are useful in the diagnosis of malignant melanoma.
authors: Department of Respiratory Medicine, University of Occupational and Environmental Health.
authors: Takaaki
authors: T
authors: Ogoshi
authors: Takashi
authors: T
authors: Kido
authors: Kazuhiro
authors: K
authors: Yatera
authors: Shuya
authors: S
authors: Nagata
authors: Chinatsu
authors: C
authors: Nishida
authors: Kei
authors: K
authors: Yamasaki
authors: Toshinori
authors: T
authors: Kawanami
authors: Hiroshi
authors: H
authors: Ishimoto
authors: Chiharu
authors: C
authors: Yoshii
authors: Hiroshi
authors: H
authors: Mukae
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D018328:Melanoma, Amelanotic / Q000556:secondary*; D012878:Skin Neoplasms / Q000473:pathology*