title: Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering.
abstract: METHODS
  In this study, gelatin was blended with polyglycolic acid (PGA) at different ratios (0, 10, 30, and 50 wt%) and electrospun. The morphology and structure of the scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The mechanical properties were also measured by the tensile test. Furthermore, for biocompatibility assessment, human umbilical vein endothelial cells and human umbilical artery smooth muscle cells were cultured on these scaffolds, and cell attachment and viability were evaluated.
  
  
  RESULTS
  PGA with 10 wt% gelatin enhanced the endothelial cells whilst PGA with 30 wt% gelatin increased smooth muscle cell adhesion, penetration, and viability compared with the other scaffold blends. Additionally, with the increase in gelatin content, the mechanical properties of the scaffolds were improved due to interaction between PGA and gelatin, as revealed by Fourier transform infrared spectroscopy and differential scanning calorimetry.
  
  
  CONCLUSIONS
  Incorporation of gelatin improves the biological and mechanical properties of PGA, making promising scaffolds for vascular tissue engineering.
authors: Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hadi.hajiali@gmail.com
authors: Hadi
authors: H
authors: Hajiali
authors: Shapour
authors: S
authors: Shahgasempour
authors: M Reza
authors: MR
authors: Naimi-Jamal
authors: Habibullah
authors: H
authors: Peirovi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D055119:Elastic Modulus; D005780:Gelatin / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014469:Umbilical Arteries / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid; D005780:Gelatin