title: Influence of surfactants on the release behaviour and structural properties of sol-gel derived silica xerogels embedded with metronidazole.
abstract: The aim of this study was to obtain stable and controlled release silica xerogels containing metronidazole (MT) prepared with surfactants with different charges: cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulphate (SDS) and hydroxypropyl cellulose (HPC), which could be the promising carrier materials used as the implantable drug delivery systems. The xerogels were prepared by the sol-gel method. The influence of various formulation precursors on porosity parameters and drug release were investigated. Addition of surfactants showed a promising result in controlling the MT release. Dissolution study revealed increased release of MT from silica modified SDS and CTAB, whereas the release of MT from silica modified HPC considerably decreased, in comparison with unmodified silica. The addition of surfactants showed slight changes in porosity parameters. All xerogels are characterized by a highly developed surface area (701-642 m(2) g(-1)) and mesoporous structure. The correlation between pore size obtained matrices and release rate of drug was also observed. Based on the presented results of this study, it may be stated that applied xerogel matrices: pure silica and surfactants-modified silica could be promising candidates for the formulation in local delivery systems.
authors: Department of Physical Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
authors: Katarzyna
authors: K
authors: Czarnobaj
authors: Wiesław
authors: W
authors: Sawicki
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D008795:Metronidazole / Q000737:chemistry*; D016062:Porosity; D058428:Silica Gel / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002593:Cetrimonium Compounds; D004337:Drug Carriers; D013501:Surface-Active Agents; D008795:Metronidazole; D012967:Sodium Dodecyl Sulfate; D058428:Silica Gel; D002482:Cellulose; C008079:hydroxypropylcellulose; D000077286:Cetrimonium