title: Bullous dermatosis associated with vancomycin extravasation.
abstract: Cutaneous side effects related to vancomycin therapy have been reported including histamine-related reactions, linear IgA bullous dermatosis, Stevens-Johnson syndrome, maculopapular rash and drug rash with eosinophilia and systemic symptoms. In all instances, these reports were due to the systemic administration of vancomycin and subsequent immunological reactions to the medication. Drug extravasation into soft tissues can result in a variety of clinical outcomes usually related to physiochemical properties of the drug extravasated and its diluents or pharmacologic effects on the vasculature and tissue. The authors report a patient who experienced vancomycin extravasation that resulted in a localized bullous eruption resembling linear IgA bullous dermatosis, a phenomenon not previously described in the literature.
authors: Department of Pharmacy Services and Division of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, South Carolina.
authors: Nicole M
authors: NM
authors: Bohm
authors: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina. Electronic address: wong@musc.edu.
authors: Jeffrey G
authors: JG
authors: Wong
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000188:drug therapy; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000188:drug therapy*; D013022:South Carolina; D016896:Treatment Outcome; D014640:Vancomycin / Q000009:adverse effects*; D014930:Women
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014640:Vancomycin; D008775:Methylprednisolone