title: Alternations of phospholipid profile in placenta of streptozotocin-induced diabetic rat.
abstract: Phospholipids have important roles in many biological processes, but their role in fetal malformation in pregnancy in diabetes is unclear. Metabolic fingerprinting of placental phospholipids in pregnant streptozotocin-induced type 1 diabetic rats was performed using Fourier transform-ion cyclotron resonance mass spectrometry. Some of the fetuses from the pregnant diabetic rats exhibited ventricular septal defects. Alterations of phospholipid compositions in the diabetic rat placenta were detected. We suggest that these changes in phospholipids in the diabetic placenta might be involved in development of fetal malformation in a type 1 diabetic pregnancy.
authors: Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.
authors: Mina
authors: M
authors: Hasegawa
authors: Katsuhiro
authors: K
authors: Tanaka
authors: Masayuki
authors: M
authors: Komori
authors: Shigeo
authors: S
authors: Takenaka
mesh_terms: D000818:Animals; D017357:Cyclotrons; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000002:abnormalities; D005583:Fourier Analysis; D006345:Heart Septal Defects, Ventricular / Q000196:embryology; D010743:Phospholipids / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D013311:Streptozocin
chemical_list: D010743:Phospholipids; D013311:Streptozocin