title: Synthesis, characterization and antibacterial studies on some mixed ligand thorium complexes with N- and O-donor ligands.
abstract: Mixed ligand Th(IV) complexes of the type [M(Q)(L)(NO3)2] x 2H2O have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/or O- donor amino acids (HL) such as L-threonine, L-tryptophan and L-isoleucine as secondary ligands. The metal complexes have been characterized on the basis of elemental analysis, electrical conductance, room temperature magnetic susceptibility measurements, spectral and thermal studies. The electrical conductance studies of the complexes in DMF in 10(-3). M concentration indicate their non-electrolytic nature. Room temperature magnetic susceptibility measurements revealed diamagnetic nature of the complexes. Electronic absorption spectra of the complexes show intra-ligand and charge transfer transitions, respectively. Bonding of the metal ion through N- and O-donor atoms of the ligands revealed by IR studies and the chemical environment of the protons is also confirmed by NMR studies. The thermal analysis data of the complexes indicate the presence of crystalline water molecules. The tube dilution method has been used to study the antibacterial activity of the complexes against the pathogenic bacteria S. aureus, C. diphtheriae, S. typhi and E. coli.
authors: Department of Chemistry, Changu Kana Thakur Arts, Commerce and Science College, New Panvel, Raigad, Maharashtra 410206, India. sunilpatil_247@rediffmail.com
authors: Sunil S
authors: SS
authors: Patil
authors: Ganesh A
authors: GA
authors: Thakur
authors: Manzoor M
authors: MM
authors: Shaikh
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003353:Corynebacterium diphtheriae / Q000187:drug effects / Q000254:growth & development; D015195:Drug Design; D004553:Electric Conductivity; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D015125:Oxyquinoline / Q000737:chemistry; D012485:Salmonella typhi / Q000187:drug effects / Q000254:growth & development; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods; D013818:Thermogravimetry; D017970:Thorium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D008024:Ligands; D017970:Thorium Compounds; D015125:Oxyquinoline; D009584:Nitrogen; D010100:Oxygen