title: Mixed SAMs and MALDI-ToF MS: preparation of N-glycosylamine derivative and thioctic acid methyl ester bearing 1,2-dithiolane groups and detection of enzymatic reaction on Au.
abstract: Herein, we report an enzymatic galactosylation reaction of β-glucopyranosylamide 4 and thioctic acid methyl ester 5 bearing 1,2-dithiolane groups to form a new system of mixed self-assembled monolayers (SAMs) on gold. Characterization of the enzymatic activity was conveniently achieved by mass spectrometry.
authors: Manchester Interdisciplinary Biocentre (MIB), University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. Electronic address: hani.mutlak.a.hassan@gmail.com.
authors: Hani Mutlak A
authors: HMA
authors: Hassan
authors: Manchester Interdisciplinary Biocentre (MIB), University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
authors: Beatrice A
authors: BA
authors: Maltman
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D004798:Enzymes / Q000378:metabolism*; D006046:Gold / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013499:Surface Properties; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C448825:1,2-dithiolane; D000588:Amines; D004798:Enzymes; D008063:Thioctic Acid; D006046:Gold; D000117:Acetylglucosamine