title: Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors.
abstract: BACKGROUND
  Maternal smoking during pregnancy (SDP) has been studied extensively as a risk factor for adverse offspring outcomes and is known to co-occur with other familial risk factors. Accounting for general familial risk factors has attenuated associations between SDP and adverse offspring outcomes, and identifying these confounds will be crucial to elucidating the relationship between SDP and its psychological correlates.
  
  
  METHODS
  The current study aimed to disentangle the relationship between maternal SDP and co-occurring risk factors (maternal criminal activity, drug problems, teen pregnancy, educational attainment, and cohabitation at childbirth) using a population-based sample of full- (n=206 313) and half-sister pairs (n=19 363) from Sweden. Logistic regression models estimated the strength of association between SDP and co-occurring risk factors. Bivariate behavioral genetic models estimated the degree to which associations between SDP and co-occurring risk factors are attributable to genetic and environmental factors.
  
  
  RESULTS
  Maternal SDP was associated with an increase in all co-occurring risk factors. Of the variance associated with SDP, 45% was attributed to genetic factors and 53% was attributed to unshared environmental factors. In bivariate models, genetic factors accounted for 21% (non-drug-, non-violence-related crimes) to 35% (drug-related crimes) of the covariance between SDP and co-occurring risk factors. Unshared environmental factors accounted for the remaining covariance.
  
  
  CONCLUSIONS
  The genetic factors that influence a woman's criminal behavior, substance abuse and her offspring's rearing environment all influence SDP. Therefore, the intergenerational transmission of genes conferring risk for antisocial behavior and substance misuse may influence the associations between maternal SDP and adverse offspring outcomes.
authors: Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
authors: J M
authors: JM
authors: Ellingson
authors: M E
authors: ME
authors: Rickert
authors: P
authors: P
authors: Lichtenstein
authors: N
authors: N
authors: Långström
authors: B M
authors: BM
authors: D'Onofrio
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000453:epidemiology* / Q000235:genetics; D015986:Confounding Factors, Epidemiologic; D003415:Crime / Q000706:statistics & numerical data; D004812:Epidemiologic Methods; D005260:Female; D059647:Gene-Environment Interaction; D005824:Genetics, Behavioral; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008957:Models, Genetic; D009035:Mothers / Q000523:psychology / Q000706:statistics & numerical data; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D035781:Siblings; D012907:Smoking / Q000453:epidemiology*; D013548:Sweden / Q000453:epidemiology