title: Anticancer treatment and thrombosis.
abstract: Venous thromboembolic (VTE) complications are common in patients with cancer and represent the second cause of death in this disease. The risk of VTE varies according to the type of malignancy and with the extent of the cancer. Patients with VTE and more advanced, metastatic disease face worse clinical outcomes. Important in this setting is the triggering role of antitumor therapies, including cancer surgery and active treatments such as chemotherapy, hormonal and anti-angiogenic therapy, which further increase the cancer-associated thrombotic risk. Predictive models for VTE in cancer patients are now available and will allow the possibility of improving outcomes for patients under chemotherapy by identifying those who would benefit most from thromboprophylaxis.
authors: Division of Immunohematology and Transfusion Medicine, Ospedali Riuniti di Bergamo, Bergamo, Italy. annafalanga@yahoo.com
authors: Anna
authors: A
authors: Falanga
authors: Marina
authors: M
authors: Marchetti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D019317:Evidence-Based Medicine; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents