title: Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene.
abstract: A unique nanocomposite was constructed by grafting an aptamer on graphene and used as a label-free biosensor for thrombin sensing, showing good selectivity, a low detection limit of 0.45 fM and high sensitivity, with a linear response up to 100 fM.
authors: Jiangsu Key Laboratory of New Power Batteries, College of Chemistry and Material Science, Nanjing Normal University, Nanjing 210097, China.
authors: Yanping
authors: Y
authors: Wang
authors: Yinghong
authors: Y
authors: Xiao
authors: Xiaoling
authors: X
authors: Ma
authors: Na
authors: N
authors: Li
authors: Xiaodi
authors: X
authors: Yang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D048271:Chitosan / Q000737:chemistry; D003217:Conductometry; D004563:Electrochemistry / Q000379:methods*; D004867:Equipment Design; D005898:Glass / Q000737:chemistry; D006108:Graphite / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D057230:Limit of Detection; D053761:Nanocomposites / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013917:Thrombin / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D006108:Graphite; D048271:Chitosan; D013917:Thrombin