title: [Quantitative analysis of hepatitis B surface antigen as a clinical marker].
abstract: There are 1.5 million hepatitis B virus (HBV) infected patients in Japan. Anti-viral therapy is important for chronic hepatitis B patients to prevent hepatocellular carcinoma. Recently, HBs antigen (HBsAg) quantification has been reported to be useful for not only HBV screening but also for monitoring of anti-viral treatment. In this paper, we evaluated the clinical utility of quantitative assay of HBsAg by HISCL HBsAg kit. Although there can be a significant difference in age, HBeAg positive/negative and viral genotype, there is not in the disease stage. Moreover, the weak correlation was confirmed between HBsAg and HBV-DNA levels with or without anti-virus treatment. In the clinical practice, as HBV-DNA becomes undetectable immediately by anti-viral therapy such as entecavir, it may be difficult to evaluate the efficacy. The monitoring of the HBsAg concentration in addition to HBV-DNA would be useful for the evaluation. Hence, the clinical role of HBsAg concentration could spread widely in Japan.
authors: Scientific Research Division, Scientific Affairs, Sysmex Corporation, Kobe 651-2241, Japan. Nakamura.Erina@sysmex.co.jp
authors: Erina
authors: E
authors: Nakamura
authors: Hirokazu
authors: H
authors: Kakuda
authors: Kentaro
authors: K
authors: Matsuura
authors: Fuminaka
authors: F
authors: Sugauchi
authors: Noboru
authors: N
authors: Shinkai
authors: Yasuhito
authors: Y
authors: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005838:Genotype; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control / Q000821:virology; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011933:Reagent Kits, Diagnostic
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D011933:Reagent Kits, Diagnostic