title: Serum levels of the adipokine chemerin in preeclampsia.
abstract: OBJECTIVE
  Hypothesising that maternal serum chemerin levels may be associated with preeclampsia, we investigated whether maternal serum chemerin levels differ between preeclamptic and healthy pregnant women. We also investigated the association of serum chemerin with metabolic parameters and the severity of the disease.
  
  
  METHODS
  This case-control study included 144 women (72 healthy and 72 preeclamptic women) in the third trimester of a singleton pregnancy. Clinical data and maternal serum were collected. The two groups were carefully matched for maternal age and gestational age. The maternal levels of serum chemerin were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The serum chemerin levels were found to be significantly increased in the women with preeclampsia (258.85±86.64 ng/mL) as compared with the healthy pregnant controls (210.80±47.34 ng/mL) (P<0.001). The serum chemerin concentrations in the severely preeclamptic women (289.6±74.43 ng/mL) were higher than those in the mildly preeclamptic women (228.1±87.99 ng/mL) (P<0.001). A stepwise regression analysis showed that the serum chemerin levels significantly and positively correlated with systolic blood pressure (P<0.001), free fatty acids (P<0.05) and serum creatinine (P<0.01).
  
  
  CONCLUSIONS
  Chemerin levels are significantly increased in preeclampsia and independently associated with markers of dyslipidemia and with the severity of the preeclampsia. Further studies need to show the onset of the chemerin increase and its putative involvement in the pathophysiology of preeclampsia.
authors: Guangdong Women and Children’s Hospital and Health Institute, The Affi liated Hospital of Guangzhou Medical College, Guangzhou, Guangdong province, PR China.
authors: Dong-Mei
authors: DM
authors: Duan
authors: Jian-Min
authors: JM
authors: Niu
authors: Qiong
authors: Q
authors: Lei
authors: Xiao-Hong
authors: XH
authors: Lin
authors: Xi
authors: X
authors: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human