title: Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
abstract: Human trisomy 21 is the most frequent live-born human aneuploidy and causes a constellation of disease phenotypes classified as Down syndrome, which include heart defects, myeloproliferative disorder, cognitive disabilities and Alzheimer-type neurodegeneration. Because these phenotypes are associated with an extra copy of a human chromosome, the genetic analysis of Down syndrome has been a major challenge. To complement human genetic approaches, mouse models have been generated and analyzed based on evolutionary conservation between the human and mouse genomes. These efforts have been greatly facilitated by Cre/loxP-mediated mouse chromosome engineering, which may result in the establishment of minimal critical genomic regions and eventually new dosage-sensitive genes associated with Down syndrome phenotypes. The success in genetic analysis of Down syndrome will further enhance our understanding of this disorder and lead to better strategies in developing effective therapeutic interventions.
authors: Children's Guild Foundation Down Syndrome Research Program, Buffalo, NY, USA.
authors: Li
authors: L
authors: Zhang
authors: Dawei
authors: D
authors: Fu
authors: Pavel V
authors: PV
authors: Belichenko
authors: Chunhong
authors: C
authors: Liu
authors: Alexander M
authors: AM
authors: Kleschevnikov
authors: Annie
authors: A
authors: Pao
authors: Ping
authors: P
authors: Liang
authors: Steven J
authors: SJ
authors: Clapcote
authors: William C
authors: WC
authors: Mobley
authors: Y Eugene
authors: YE
authors: Yu
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics*; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D051379:Mice