title: A novel correction factor based on extended volume to complement the conformity index.
abstract: OBJECTIVE
  We propose a modified conformity index (MCI), based on extended volume, that improves on existing indices by correcting for the insensitivity of previous conformity indices to reference dose shape to assess the quality of high-precision radiation therapy and present an evaluation of its application.
  
  
  METHODS
  In this paper, the MCI is similar to the conformity index suggested by Paddick (CI(Paddick)), but with a different correction factor. It is shown for three cases: with an extended target volume, with an extended reference dose volume and without an extended volume. Extended volume is generated by expanding the original volume by 0.1-1.1 cm isotropically. Focusing on the simulation model, measurements of MCI employ a sphere target and three types of reference doses: a sphere, an ellipsoid and a cube. We can constrain the potential advantage of the new index by comparing MCI with CI(Paddick). The measurements of MCI in head-neck cancers treated with intensity-modulated radiation therapy and volumetric-modulated arc therapy provide a window on its clinical practice.
  
  
  RESULTS
  The results of MCI for a simulation model and clinical practice are presented and the measurements are corrected for limited spatial resolution. The three types of MCI agree with each other, and comparisons between the MCI and CI(Paddick) are also provided.
  
  
  CONCLUSIONS
  The results from our analysis show that the proposed MCI can provide more objective and accurate conformity measurement for high-precision radiation therapy. In combination with a dose-volume histogram, it will be a more useful conformity index.
authors: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing City, China.
authors: F
authors: F
authors: Jin
authors: Y
authors: Y
authors: Wang
authors: Y-Z
authors: YZ
authors: Wu
mesh_terms: D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care; D011786:Quality Control; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D020266:Radiotherapy, Conformal / Q000592:standards*; D050397:Radiotherapy, Intensity-Modulated / Q000592:standards; D012015:Reference Standards; D018570:Risk Assessment; D047368:Tumor Burden