title: A prospective survey of febrile events in hematological malignancies.
abstract: The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.
authors: Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, I-00168, Roma, Italy. lpagano@rm.unicatt.it.
authors: L
authors: L
authors: Pagano
authors: Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, I-00168, Roma, Italy.
authors: M
authors: M
authors: Caira
authors: U.O. Ematologia, Spedali Civili, Brescia, Italy.
authors: G
authors: G
authors: Rossi
authors: Istituto di Malattie Infettive, Università Cattolica S. Cuore, Roma, Italy.
authors: M
authors: M
authors: Tumbarello
authors: Azienda Osp. Univ. Careggi, Ematologia, Firenze, Italy.
authors: R
authors: R
authors: Fanci
authors: Divisione di Ematologia Az. Osp. S. Camillo Forlanini, Roma, Italy.
authors: M G
authors: MG
authors: Garzia
authors: Istituto Seragnoli, Università di Bologna, Bologna, Italy.
authors: N
authors: N
authors: Vianelli
authors: Ematologia, Azienda Osp. Osp. S. Carlo, Potenza, Italy.
authors: N
authors: N
authors: Filardi
authors: Ematologia, Ospedale S. Eugenio, Roma, Italy.
authors: P
authors: P
authors: De Fabritiis
authors: U.O. Ematologia Pol. Univ. Tor Vergata, Roma, Italy.
authors: A
authors: A
authors: Beltrame
authors: Dipartimento di Ematoncologia ed Unità Trap. Mid. Osseo, La Maddalena, Palermo, Italy.
authors: M
authors: M
authors: Musso
authors: Divione di Ematologia, Ospedale Generale di Bolzano, Bologna, Italy.
authors: A
authors: A
authors: Piccin
authors: Istituto di Ematologia, Az. Osp. Univ. Arcispedale S. Anna, Ferrara, Italy.
authors: A
authors: A
authors: Cuneo
authors: U.O. Ematologia, Spedali Civili, Brescia, Italy.
authors: C
authors: C
authors: Cattaneo
authors: Istituto di Ematologia, Università di Perugia, Perugia, Italy.
authors: T
authors: T
authors: Aloisi
authors: Divisione di Ematologia e Centro Trapianti Midollo, Ospedale Niguarda Ca' Granda, Milano, Italy.
authors: M
authors: M
authors: Riva
authors: Unità di Ematologia, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
authors: G
authors: G
authors: Rossi
authors: Divisione di Ematologia, Ospedale Civile "Ca Foncello", Treviso, Italy.
authors: U
authors: U
authors: Salvadori
authors: Ematologia, Ospedale Papardo, Messina, Italy.
authors: M
authors: M
authors: Brugiatelli
authors: Divisione di Ematologia, Umberto I, Mestre, Italy.
authors: S
authors: S
authors: Sannicolò
authors: Divisione di Ematologia, Policlinico Universitario di Modena e Reggio, Modena, Italy.
authors: M
authors: M
authors: Morselli
authors: Divisione di Ematologia, Arciospedale S. Maria Nuova, Reggio Emilia, Italy.
authors: A
authors: A
authors: Bonini
authors: Clinica di Malattie Infettive, Università di Bologna, Bologna, Italy.
authors: P
authors: P
authors: Viale
authors: Divisione di Ematologia e Centro Trapianti Midollo, Ospedale Niguarda Ca' Granda, Milano, Italy.
authors: A
authors: A
authors: Nosari
authors: Istituto di Ematologia, Università di Perugia, Perugia, Italy.
authors: F
authors: F
authors: Aversa
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000401:mortality; D060085:Coinfection / Q000150:complications / Q000401:mortality; D005334:Fever / Q000209:etiology*; D019337:Hematologic Neoplasms / Q000150:complications* / Q000401:mortality; D006801:Humans; D009181:Mycoses / Q000150:complications / Q000401:mortality; D011446:Prospective Studies; D014777:Virus Diseases / Q000150:complications / Q000401:mortality