title: Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs.
abstract: Dogs do not appear to progress from obesity-induced insulin resistance to type 2 diabetes mellitus. Both postprandial hyperglycemia and postprandial hypertriglyceridemia have been proposed to cause or maintain beta cell failure and progression to type 2 diabetes mellitus in other species. Postprandial glucose, triglyceride, and insulin concentrations have not been compared in lean and obese dogs. We measured serum glucose, triglyceride, and insulin concentrations in nine naturally occurring obese and nine age- and gender-matched lean dogs. After a 24-h fast, dogs were fed half their calculated daily energy requirement of a standardized diet that provided 37% and 40% of metabolizable energy as carbohydrate and fat, respectively. Fasting and postprandial glucose and triglyceride concentrations were greater in the obese dogs (P < 0.001), although the mean insulin concentration for this group was five times greater than that of the lean group (P < 0.001). Most of the 0.6 mM (11 mg/dL) difference in mean postprandial glucose concentrations between lean and obese dogs was attributable to a subset of persistently hyperglycemic obese dogs with mean postprandial glucose concentrations 1.0 mM (18 mg/dL) greater than that in lean dogs. Persistently hyperglycemic obese dogs had lower triglyceride (P = 0.02 to 0.04) and insulin (P < 0.02) concentrations than other obese dogs. None of the dogs developed clinical signs of diabetes mellitus during follow-up for a median of 2.6 yr. We conclude that pancreatic beta cells in dogs are either not sensitive to toxicity because of mild hyperglycemia or lack another component of the pathophysiology of beta cell failure in type 2 diabetes mellitus.
authors: Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, Queensland, Australia. k.verkest@uq.edu.au
authors: K R
authors: KR
authors: Verkest
authors: J S
authors: JS
authors: Rand
authors: L M
authors: LM
authors: Fleeman
authors: J M
authors: JM
authors: Morton
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000378:metabolism; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000097:blood* / Q000662:veterinary*; D019518:Postprandial Period; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides