title: Trichomegaly and other external eye side effects associated with epidermal growth factor.
abstract: OBJECTIVE
  To report an association between epithelial growth factor receptor (EGFR) inhibitors and ocular side effects.
  
  
  METHODS
  Collection of spontaneous reports at the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oregon) in conjunction with a literature review of EGFR inhibitors associated with ocular adverse drug reactions (ADR).
  
  
  RESULTS
  EGFR inhibitors are associated with conjunctivitis, meibomitis, dry eyes, periocular skin changes and trichomegaly. EGFR inhibitors may also cause superficial punctate corneal changes and corneal erosions.
  
  
  CONCLUSIONS
  This is the first overview of all known ocular side effects associated with the use of marketed EGFR inhibitors. This is also the first effort for this class of drugs using the World Health Organization Classification as to causality.
  
  
  CONCLUSIONS
  Ophthalmologists should be aware of possible adverse ocular side effects from EGFR inhibitors and treat based on the type of ADR encountered. All ocular side effects noted are fully reversible upon discontinuation of the drug.
authors: Casey Eye Institute, Portland, OR 97239, USA.
authors: Frederick T
authors: FT
authors: Fraunfelder
authors: Frederick W
authors: FW
authors: Fraunfelder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004815:Epidermal Growth Factor / Q000009:adverse effects*; D005123:Eye / Q000187:drug effects*; D005260:Female; D006201:Hair Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004815:Epidermal Growth Factor