title: IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.
abstract: Pancreatic cancer is one of the most malignant diseases in the world. Interferon regulator factor 2 (IRF-2), an interferon regulatory factor, has been known to act as an oncogene in distinct types of cancer. In this study, we found that the expression of IRF-2 was up-regulated in primary pancreatic cancer samples and associated with tumor size, differentiation, tumor-node-metastasis stage, and survival of the patients. In pancreatic cancer cells, knockdown on the expression of IRF-2 inhibited cell growth in the liquid culture and on the soft agar. Mechanistically, IRF-2 modulated the growth of pancreatic cancer cells through regulating proliferation and apoptosis effectors, such as cyclin D1 and BAX. Collectively, these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.
authors: General Surgery Department, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
authors: Lei
authors: L
authors: Cui
authors: Yuezhen
authors: Y
authors: Deng
authors: Yefei
authors: Y
authors: Rong
authors: Wenhui
authors: W
authors: Lou
authors: Zhengfa
authors: Z
authors: Mao
authors: Yuanyuan
authors: Y
authors: Feng
authors: Dong
authors: D
authors: Xie
authors: Dayong
authors: D
authors: Jin
mesh_terms: D000328:Adult; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D050836:Interferon Regulatory Factor-2 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015854:Up-Regulation
chemical_list: D050836:Interferon Regulatory Factor-2