title: Planar cell polarity signaling in craniofacial development.
abstract: Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
authors: Northwestern University, Feinberg School of Medicine, Department of Pediatrics, Children’s Memorial Research Center, Chicago, IL, USA. j-topczewski@northwestern.edu
authors: Jacek
authors: J
authors: Topczewski
authors: Rodney M
authors: RM
authors: Dale
authors: Barbara E
authors: BE
authors: Sisson
mesh_terms: D000818:Animals; D016764:Cell Polarity; D005145:Face / Q000196:embryology*; D009432:Neural Crest / Q000166:cytology; D015398:Signal Transduction; D012886:Skull / Q000166:cytology* / Q000196:embryology*; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D051153:Wnt Proteins