title: Fiber-reinforced calcium phosphate cement formulations for cranioplasty applications: a 52-week duration preclinical rabbit calvaria study.
abstract: The in vivo tissue response to a newly developed fiber-reinforced calcium phosphate cement (CPC) formulation was assessed using a well-established rabbit calvarial defect model. Bilateral subcritical sized (8-mm diameter) defects were surgically created in the parietal bones of each rabbit (a total of 48 rabbits), and randomized to be filled with either the new fiber-reinforced formulation, a conventional CPC (positive control), or left unfilled (negative control). The implant sites were subsequently retrieved after 12, 24, and 52 weeks postsurgery. Each specimen, including the parietal bone craniotomy and underlying brain, were recovered at necropsy and the tissue responses were assessed by histology. The resulting histological slides indicated that there was no evidence of severe inflammatory responses or osteolysis. The data showed new dural and pericranial bone formation along the implants, as well as excellent bone-to-implant interfaces in all of the CPC-filled defects. These results suggest that the biologic response to the new fiber-reinforced CPC formulations and conventional nonreinforced CPC are very similar, and both demonstrate excellent biocompatibility as well as an overall osteophylic response.
authors: Department of Biomedical Engineering, Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15219, USA.
authors: Jinku
authors: J
authors: Kim
authors: Sean
authors: S
authors: McBride
authors: Mark
authors: M
authors: Fulmer
authors: Robert
authors: R
authors: Harten
authors: Zach
authors: Z
authors: Garza
authors: David D
authors: DD
authors: Dean
authors: Victor L
authors: VL
authors: Sylvia
authors: Bruce
authors: B
authors: Doll
authors: Tahlia L
authors: TL
authors: Wolfgang
authors: Elliott
authors: E
authors: Gruskin
authors: Jeffrey O
authors: JO
authors: Hollinger
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D001921:Brain / Q000473:pathology; D002130:Calcium Phosphates / Q000737:chemistry*; D005260:Female; D006801:Humans; D008422:Materials Testing; D011208:Powders; D011312:Pressure; D011817:Rabbits; D011897:Random Allocation; D012886:Skull / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D011208:Powders; C020243:calcium phosphate