title: Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.
abstract: We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.
authors: University Medical Center Rizk Hospital, Beirut, Lebanon.
authors: Rita
authors: R
authors: Nemr
authors: Ahmad W
authors: AW
authors: Almawi
authors: Akram
authors: A
authors: Echtay
authors: Mai S
authors: MS
authors: Sater
authors: Hoda S
authors: HS
authors: Daher
authors: Wassim Y
authors: WY
authors: Almawi
mesh_terms: D018912:Arabs / Q000235:genetics*; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics*; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007861:Lebanon / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors; D012359:tRNA Methyltransferases
chemical_list: C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D014157:Transcription Factors; D012359:tRNA Methyltransferases; D051360:Cyclin-Dependent Kinase 5; C525110:CDKAL1 protein, human