title: Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.
abstract: In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.
authors: Clinical and Experimental Neuroscience, School of Medicine, Murcia, Spain.
authors: P
authors: P
authors: Heman
authors: C
authors: C
authors: Barcia
authors: A
authors: A
authors: Gómez
authors: C M
authors: CM
authors: Ros
authors: F
authors: F
authors: Ros-Bernal
authors: J E
authors: JE
authors: Yuste
authors: V
authors: V
authors: de Pablos
authors: E
authors: E
authors: Fernandez-Villalba
authors: M R
authors: MR
authors: Toledo-Cárdenas
authors: M T
authors: MT
authors: Herrero
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004298:Dopamine / Q000172:deficiency; D005260:Female; D020267:MPTP Poisoning / Q000473:pathology*; D008251:Macaca; D008297:Male; D009929:Organ Size; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011689:Purkinje Cells / Q000378:metabolism / Q000473:pathology*; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D004298:Dopamine