title: A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist.
abstract: OBJECTIVE
  To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with ovarian hyperstimulation who was treated with a gonadotropin-releasing hormone (GnRH) antagonist.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.
  
  
  METHODS
  Clinical treatment with a GnRH antagonist.
  
  
  METHODS
  A decrease in serum estradiol levels.
  
  
  RESULTS
  During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient's clinical condition and in the ultrasonography parameters.
  
  
  CONCLUSIONS
  The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases.
authors: Department of Clinical Medicine/Endocrinology, School of Medicine, University of Campinas, Campinas, Brazil.
authors: Heraldo Mendes
authors: HM
authors: Garmes
authors: Oswaldo Rocha
authors: OR
authors: Grassiotto
authors: Yvens Barbosa
authors: YB
authors: Fernandes
authors: Luciano de Souza
authors: Lde S
authors: Queiroz
authors: José
authors: J
authors: Vassalo
authors: Daniel Minutti
authors: DM
authors: de Oliveira
authors: Cristina Laguna
authors: CL
authors: Benetti-Pinto
mesh_terms: D000236:Adenoma / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D000328:Adult; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000008:administration & dosage; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy* / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D043373:Follicle Stimulating Hormone, Human; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C061018:ganirelix