title: Genetic variation in CD83 and risks of cervical and vulvar cancers: a population-based case-control study.
abstract: OBJECTIVE
  The CD83 glycoprotein is a marker of dendritic cell maturation that may contribute to the T cell response to oncogenic human papillomavirus (HPV) infection. Whether single nucleotide polymorphisms (SNPs) in CD83 influence the risk of HPV-related genital cancers has not been adequately studied. We investigated whether the common genetic variation of the CD83 region was associated with the risks of cervical and vulvar cancers in a population-based case-control study conducted in the Seattle-Puget Sound Region.
  
  
  METHODS
  A total of 17 tagSNPs were genotyped in the CD83 region of 886 cervical cases, 517 vulvar cases and 1100 controls. Odds ratio (OR) and 95% confidence intervals (CI) were computed to assess the risk of cervical and vulvar cancers. The interaction between the tagSNPs and cigarette smoking was also explored.
  
  
  RESULTS
  TagSNPs in the CD83 chromosomal region were not associated with risk of either cervical or vulvar cancer. TagSNP rs853360 was associated with a decreased risk of cervical squamous cell carcinoma (SCC) (OR=0.80; 95% CI: 0.66-0.98).
  
  
  CONCLUSIONS
  Our results do not suggest that the common genetic variation of CD83 is related to cervical or vulvar cancers. The association between tagSNP rs853360 and risk of cervical SCC is likely to be due to chance. If larger or pooled studies confirm our results, CD83 has little or no influence in the risk of HPV-related cancers.
authors: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. clara.bodelon@nih.gov
authors: Clara
authors: C
authors: Bodelon
authors: Margaret M
authors: MM
authors: Madeleine
authors: Lisa G
authors: LG
authors: Johnson
authors: Qin
authors: Q
authors: Du
authors: Mari
authors: M
authors: Malkki
authors: Effie W
authors: EW
authors: Petersdorf
authors: Stephen M
authors: SM
authors: Schwartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000009:adverse effects / Q000235:genetics / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology; D014846:Vulvar Neoplasms / Q000235:genetics* / Q000276:immunology; D055815:Young Adult; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen