title: Early-life origins of type 2 diabetes: fetal programming of the beta-cell mass.
abstract: A substantial body of evidence suggests that an abnormal intrauterine milieu elicited by maternal metabolic disturbances as diverse as undernutrition, placental insufficiency, diabetes or obesity, may program susceptibility in the fetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes. This paper examines the developmental programming of glucose intolerance/diabetes by disturbed intrauterine metabolic condition experimentally obtained in various rodent models of maternal protein restriction, caloric restriction, overnutrition or diabetes, with a focus on the alteration of the developing beta-cell mass. In most of the cases, whatever the type of initial maternal metabolic stress, the beta-cell adaptive growth which normally occurs during gestation, does not take place in the pregnant offspring and this results in the development of gestational diabetes. Therefore gestational diabetes turns to be the ultimate insult targeting the offspring beta-cell mass and propagates diabetes risk to the next generation again. The aetiology and the transmission of spontaneous diabetes as encountered in the GK/Par rat model of type 2 diabetes, are discussed in such a perspective. This review also discusses the non-genomic mechanisms involved in the installation of the programmed effect as well as in its intergenerational transmission.
authors: Université Paris-Diderot, Sorbonne-Paris-Cité, Laboratoire B2PE, Unité BFA, EAC 4413 Centre National de la Recherche Scientifique, 75205 Paris, France. portha@univ-paris-diderot.fr
authors: Bernard
authors: B
authors: Portha
authors: Audrey
authors: A
authors: Chavey
authors: Jamileh
authors: J
authors: Movassat
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics; D016640:Diabetes, Gestational; D004195:Disease Models, Animal; D002149:Energy Intake; D005260:Female; D047109:Fetal Development; D006801:Humans; D050417:Insulin-Secreting Cells; D008297:Male; D051379:Mice; D044343:Overnutrition; D010179:Pancreas / Q000196:embryology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011297:Prenatal Exposure Delayed Effects; D011488:Protein Deficiency; D051381:Rats; D012307:Risk Factors