title: Cross-strain quorum sensing inhibition by Staphylococcus aureus. Part 2: A spatially inhomogeneous model.
abstract: Staphylococcus aureus uses quorum sensing (QS) to enhance its pathogenicity. An intriguing aspect of this is that different strains are capable of inactivating the QS systems of opposing strains. In Part 1 of this study, we presented a model of this phenomenon in a well-mixed environment; here, we incorporate spatial structure. Two competitive strains occupying adjacent habitats with freely diffusing QS signal molecules (QSSMs) are considered. We investigate the effect of the QSSM diffusion coefficient and the relative size of the two populations on the ability of one population to dominate the other. Regarding population size, a larger population is generally at an advantage (initial conditions permitting), while the implications of different diffusivities are more complex and depend upon the sizes of the populations.
authors: Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK. sara.jabbari@nottingham.ac.uk
authors: Sara
authors: S
authors: Jabbari
authors: John R
authors: JR
authors: King
authors: Paul
authors: P
authors: Williams
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D017753:Ecosystem; D008954:Models, Biological; D053038:Quorum Sensing / Q000502:physiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology
chemical_list: C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D015534:Trans-Activators