title: Familial adenomatous polyposis: clinical presentation, detection and surveillance.
abstract: Colorectal cancer (CRC) is a leading cause of cancer related death in the western countries. It remains an important health problem, often under-diagnosed. The symptoms can appear very late and about 25% of the patients are diagnosed at metastatic stage. Familial adenomatous polyposis (FAP) is an inherited colorectal cancer syndrome, characterized by the early onset of hundred to thousands of adenomatous polyps in the colon and rectum. Left untreated, there is a nearly 100% cumulative risk of progression to CRC by the age of 35-40 years, as well as an increased risk of various other malignancies. CRC can be prevented by the identification of the high risk population and by the timely implementation of rigid screening programs which will lead to special medico-surgical interventions.
authors: Belgian Polyposis Project, Familial Adenomatous Polyposis Association (FAPA), Brussels. Stephanie.laurent@uzgent.be
authors: S
authors: S
authors: Laurent
authors: D
authors: D
authors: Franchimont
authors: J P
authors: JP
authors: Coppens
authors: K
authors: K
authors: Leunen
authors: L
authors: L
authors: Macken
authors: M
authors: M
authors: Peeters
authors: O
authors: O
authors: Plomteux
authors: M
authors: M
authors: Polus
authors: B
authors: B
authors: Poppe
authors: C
authors: C
authors: Sempoux
authors: S
authors: S
authors: Tejpar
authors: M
authors: M
authors: Van Den Eynde
authors: A
authors: A
authors: Van Gossum
authors: J
authors: J
authors: Vannoote
authors: A
authors: A
authors: Kartheuser
authors: E
authors: E
authors: Van Cutsem
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000379:methods*; D011159:Population Surveillance / Q000379:methods*; D012307:Risk Factors