title: A simplified model for mitral valve dynamics.
abstract: Located between the left atrium and the left ventricle, the mitral valve controls flow between these two cardiac chambers. Mitral valve dysfunction is a major cause of cardiac dysfunction and its dynamics are little known. A simple non-linear rotational spring model is developed and implemented to capture the dynamics of the mitral valve. A measured pressure difference curve was used as the input into the model, which represents an applied torque to the anatomical valve chords. A range of mechanical model hysteresis states were investigated to find a model that best matches reported animal data of chord movement during a heartbeat. The study is limited by the use of one dataset found in the literature due to the highly invasive nature of getting this data. However, results clearly highlight fundamental physiological issues, such as the damping and chord stiffness changing within one cardiac cycle, that would be directly represented in any mitral valve model and affect behaviour in dysfunction. Very good correlation was achieved between modeled and experimental valve angle with 1-10% absolute error in the best case, indicating good promise for future simulation of cardiac valvular dysfunction, such as mitral regurgitation or stenosis. In particular, the model provides a pathway to capturing these dysfunctions in terms of modeled stiffness or elastance that can be directly related to anatomical, structural defects and dysfunction.
authors: Cardiovascular Research Center, University of Liège, 17 Allée du 6 Août, Liège 4000, Belgium.
authors: K T
authors: KT
authors: Moorhead
authors: S
authors: S
authors: Paeme
authors: J G
authors: JG
authors: Chase
authors: P
authors: P
authors: Kolh
authors: L
authors: L
authors: Pierard
authors: C E
authors: CE
authors: Hann
authors: P C
authors: PC
authors: Dauby
authors: T
authors: T
authors: Desaive
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena / Q000502:physiology; D006801:Humans; D008943:Mitral Valve / Q000502:physiology*; D008953:Models, Anatomic; D008955:Models, Cardiovascular