title: Thioredoxin interacting protein (TXNIP) rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population.
abstract: Thioredoxin interacting protein plays a pivotal role in several important processes of cardiovascular homeostasis by functioning as a biological sensor for biomechanical and oxidative stress. However, the effects of genetic variants in the modulation of arterial stiffness are unknown. In this scenario, the present study evaluated the relationship between the TXNIP rs7212 polymorphism and arterial stiffness. In the overall sample and in the diabetic group, individuals carrying CG+GG genotypes had higher PWV values compared with CC genotype group (10.0 vs 9.8 m s (-1), P=0.03; 12.3 vs 11.2 m s(-1), P=0.01; respectively). Our findings indicated that the G allele may contribute to increased arterial stiffness in the Brazilian general population and suggest a possible interaction with diabetes.
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.
authors: R O
authors: RO
authors: Alvim
authors: P C J L
authors: PC
authors: Santos
authors: N E
authors: NE
authors: Ferreira
authors: J G
authors: JG
authors: Mill
authors: J E
authors: JE
authors: Krieger
authors: A C
authors: AC
authors: Pereira
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D001938:Brazil; D002352:Carrier Proteins / Q000235:genetics*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000235:genetics / Q000503:physiopathology; D004548:Elasticity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D014652:Vascular Diseases / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology
chemical_list: D002352:Carrier Proteins; C486715:TXNIP protein, human