title: Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells.
abstract: OBJECTIVE
  The purpose was to investigate Chios mastic gum (CMG) extract as an potential anti-tumor agent for oral squamous cell carcinoma in vitro.
  
  
  METHODS
  We designed a study to examine the effects of CMG extracts on growth of oral squamous cell carcinoma cell line, YD-10B and to determine whether the extracts could induce apoptosis through the activation of caspase-3, using the common chemotherapeutic agent Paclitaxel (Taxol, Bristol-Myers Squibb) as a control.
  
  
  RESULTS
  MTT assay suggested that both CMG and Taxol inhibited the proliferation of YD-10B cells in a time and dose dependent manner. Moreover, 10 μg/mL of CMG and 50 μg/mL of Taxol caused fragmentation of the genomic DNA at 24 hour. Finally, 10 μg/mL of CMG and 50 μg/mL of Taxol caused cleavage of procaspase-3 in western blot analysis.
  
  
  CONCLUSIONS
  These results suggest CMG's potential as an anti-tumor agent.
authors: Department of Pathology, Yanbian University, Yanji City, PR.
authors: ShengJin
authors: S
authors: Li
authors: In-Ho
authors: IH
authors: Cha
authors: Woong
authors: W
authors: Nam
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000069997:Mastic Resin; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000494:pharmacology / Q000627:therapeutic use; D027927:Pistacia / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012116:Resins, Plant / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000069997:Mastic Resin; D010936:Plant Extracts; D012116:Resins, Plant; D004247:DNA; C505407:CASP3 protein, human; D053148:Caspase 3; D017239:Paclitaxel