title: Cutaneous lymphoma in a patient with ulcerative colitis after immunosuppressive therapy.
abstract: BACKGROUND
  Biologics are generally safe and well tolerated. However, the risk of haematopoietic cancer in patients with inflammatory bowel disease receiving infliximab has been a growing concern.
  
  
  METHODS
  We report the first case of cutaneous lymphoma after short use of infliximab in 75-year old Caucasian man with a 7-year history of ulcerative colitis.
  
  
  CONCLUSIONS
  Our current knowledge is not sufficient to rule out an increased risk of lymphoma associated with biologics, or allow definitive conclusions to be drawn about the association of infliximab and lymphoma. However, this case and others direct the attention to that both higher index of suspicion and closer follow up are required if patients are maintained on long-term infliximab together with other immunosuppressive therapy.
authors: Unit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, Ctra de Cadiz s/n, Sevilla 41014, Spain. mrojasferia@yahoo.es
authors: Maria
authors: M
authors: Rojas-Feria
authors: Mohammed
authors: M
authors: Eslam
authors: Manuel
authors: M
authors: Castro-Fernández
authors: Pedro
authors: P
authors: Guerrero
authors: Jose-Luis
authors: JL
authors: Larraona-Moreno
authors: Manuel
authors: M
authors: Romero-Gómez
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy*; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D012878:Skin Neoplasms / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D000069285:Infliximab; D001379:Azathioprine