title: A battle for iron: host sequestration and Staphylococcus aureus acquisition.
abstract: The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently most living organisms, including pathogenic bacteria, require iron to survive and replicate. To combat infection vertebrates have evolved sophisticated iron sequestration systems against which, pathogenic bacteria have concomitantly evolved equally elaborate iron acquisition mechanisms.
authors: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave., South, A5102 MCN, Nashville, TN 37232-2363, USA.
authors: Kathryn P
authors: KP
authors: Haley
authors: Eric P
authors: EP
authors: Skaar
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006418:Heme / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D007501:Iron / Q000378:metabolism*; D017262:Siderophores / Q000378:metabolism; D013203:Staphylococcal Infections / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D013211:Staphylococcus aureus / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D006454:Hemoglobins; D017262:Siderophores; D037521:Virulence Factors; D006418:Heme; D007501:Iron; D006419:Heme Oxygenase (Decyclizing)