title: Dural metastasis of atypical extraventricular neurocytoma with the codeletion of chromosomes 1p/19q.
abstract: Extraventricular neurocytoma (EVN) is a rare neoplasm described in the 2007 World Health Organization classification of tumours of the nervous system. Due to the rarity of the tumour, there is limited literature available. The clinical characteristics, pathological features, biological  behaviour and outcome of EVN remain unclear, and there are challenges regarding its diagnosis and management. The present case was a 75-year-old man who had been experiencing slow responses to stimuli for 1 month prior to hospital admission. A diagnosis of atypical EVN was made on the basis  of pathology and immunohistochemistry results. Atypical pathological features included vascular proliferation, the presence of mitosis and a high MIB-1 (an antibody against Ki-67) labelling index. The disease recurred 7 months after the initial complete resection and radiation treatment, presenting  with dural metastasis and codeletion of chromosomes 1p/19q. The present case history and treatment course are discussed with respect to the literature.
authors: Department of Neurosurgery, School of Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
authors: L
authors: L
authors: Wang
authors: G
authors: G
authors: Chen
authors: H
authors: H
authors: Wei
authors: F
authors: F
authors: Liu
authors: H
authors: H
authors: Hu
authors: J
authors: J
authors: Zhang
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D004388:Dura Mater / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D018306:Neurocytoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D011877:Radionuclide Imaging