title: Evaluation of corneal endothelial cell loss and corneal thickness after cataract removal with light-adjustable intraocular lens implantation: 12-month follow-up.
abstract: OBJECTIVE
  To determine quantitative changes in endothelial cell loss and corneal thickness in patients having cataract surgery and implantation of a light-adjustable intraocular lens (IOL) to correct residual postoperative refractive errors by application of a spatially profiled near-ultraviolet (UV) light.
  
  
  METHODS
  Ruhr University Eye Clinic, Bochum, Germany.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  The light-adjustable IOLs were implanted after phacoemulsification cataract surgery and treated with spatial-intensity-profiled UV light at 365 nm to induce a targeted refractive change. Once the desired correction was achieved, the light-adjustable IOL was treated again to lock-in the lens power. Noncontact computer-assisted endothelial cell microscopy and corneal pachymetry were performed before surgery; after surgery before adjustment; before lock-in; and 1, 3, 6, and 12 months after final lock-in.
  
  
  RESULTS
  One hundred twenty-two eyes were evaluated 12 months after lock-in. The mean cumulative UV light dose at the cornea was 61.47 J/cm(2) ± 2.37 (SD). The mean endothelial cell loss was 6.91% ± 3.66% 2 weeks after surgery before adjustment and 6.57% ± 3.81% 12 months after lock-in. The mean relative change in corneal thickness from preoperatively was 6.18% ± 3.97% 2 weeks postoperatively and -0.64% ± 1.88% 12 months after lock-in.
  
  
  CONCLUSIONS
  Endothelial cell loss and corneal thickness change 12 months after lock-in agreed well with those reported in the literature after phacoemulsification with IOL implantation. The UV light exposure for adjustment and lock-in procedures did not add to the endothelial damage caused by the cataract surgery.
authors: Center for Vision Science, Ruhr University Eye Clinic, Bad Hersfeld, Germany. fritz.hengerer@kk-bochum.de
authors: Fritz H
authors: FH
authors: Hengerer
authors: H Burkhard
authors: HB
authors: Dick
authors: Simone
authors: S
authors: Buchwald
authors: Werner W
authors: WW
authors: Hütz
authors: Ina
authors: I
authors: Conrad-Hengerer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003315:Cornea / Q000473:pathology*; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis* / Q000209:etiology; D019781:Corneal Topography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012029:Refraction, Ocular / Q000502:physiology; D013997:Time Factors; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology