title: Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
abstract: BACKGROUND
  Previous studies have extensively reported the deposition of amyloid β (Aβ) peptide with carboxyl- and amino-terminal heterogeneity in cortical and cerebrovascular deposits in Alzheimer's disease (AD) and in non-human primates except baboons.
  
  
  METHODS
  We examined the immunocytochemical distribution of Aβ peptides and Aβ oligomers in brain tissue from three subspecies of 18- to 28-year-old baboons (Papio) and in other monkeys including the squirrel (Saimiri sciureus) and rhesus (Macaca mulatta) for comparison.
  
  
  RESULTS
  A general preponderance of Aβ(42) in parenchymal deposits and many vascular deposits in all cortical lobes was evident in the baboons. Aβ oligomeric immunoreactivity was also apparent like to amyloid plaques. We found that the amino acid sequence of the Aβ domain of the baboon amyloid precursor protein is similar to that of man. In contrast to Aβ, immunoreactivity to hyperphosphorylated tau protein was largely intracellular and rare in these baboons. Brain tissues from squirrel and rhesus monkeys examined in parallel exhibited mostly vascular and parenchymal deposits containing Aβ(42) peptides. Our results were comparable to AD, but showed that even in younger monkeys exhibiting few deposits, Aβ(42) was evident in both parenchymal deposits and cerebral amyloid angiopathy. Perivascular amyloid deposits were frequent and often accompanied by microvascular abnormalities in the form of collapsed degenerated capillaries.
  
  
  CONCLUSIONS
  Similar to other primates above and below in the phylogenetic order, our observations and evaluation of the literature implicate pathogenicity of Aβ(42) peptide associated with microvascular degeneration in baboons. We suggest baboons are useful animals to investigate the dynamics of AD-related pathology.
authors: Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya.
authors: M
authors: M
authors: Ndung'u
authors: W
authors: W
authors: Härtig
authors: F
authors: F
authors: Wegner
authors: J M
authors: JM
authors: Mwenda
authors: R W C
authors: RW
authors: Low
authors: R O
authors: RO
authors: Akinyemi
authors: R N
authors: RN
authors: Kalaria
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008253:Macaca mulatta; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology*; D010215:Papio; D058225:Plaque, Amyloid / Q000378:metabolism / Q000473:pathology*; D012453:Saimiri
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor