title: Probiotic yogurt improves antioxidant status in type 2 diabetic patients.
abstract: OBJECTIVE
  Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.
  
  
  METHODS
  Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.
  
  
  RESULTS
  Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).
  
  
  CONCLUSIONS
  The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.
authors: Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Hanie S
authors: HS
authors: Ejtahed
authors: Javad
authors: J
authors: Mohtadi-Nia
authors: Aziz
authors: A
authors: Homayouni-Rad
authors: Mitra
authors: M
authors: Niafar
authors: Mohammad
authors: M
authors: Asghari-Jafarabadi
authors: Vahid
authors: V
authors: Mofid
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001644:Bifidobacterium; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007779:Lactobacillus acidophilus; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D019936:Probiotics / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000097:blood; D015014:Yogurt / Q000382:microbiology*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005979:Glutathione Peroxidase; D006442:Glycated Hemoglobin; D007328:Insulin; D008315:Malondialdehyde; D013482:Superoxide Dismutase