title: A patient on RIPE therapy presenting with recurrent isoniazid-associated pleural effusions: a case report.
abstract: BACKGROUND
  The clinical scenario of a new or worsening pleural effusion following the initiation of antituberculous therapy has been classically referred to as a 'paradoxical' pleural response, presumably explained by an immunological rebound phenomenon. Emerging evidence suggests that there also may be a role for a lupus-related reaction in the pathophysiology of this disorder.
  
  
  METHODS
  An 84-year-old Asian man treated with isoniazid, along with rifampin, pyrazinamide and ethambutol for suspected extrapulmonary tuberculosis, presented with a recurrent pleural effusion, his third episode since the initiation of this therapy. The first effusion occurred one month after the start of treatment, without any prior evidence of pulmonary tuberculosis involvement. Follow-up testing, including thoracoscopic pleural biopsies, never confirmed tuberculosis infection. Further evaluation yielded serological evidence suggesting drug-induced lupus. No effusions recurred following the discontinuation of isoniazid, although other antituberculosis medications were continued.
  
  
  CONCLUSIONS
  The immunological rebound construct is inconsistent with the evolution of this case, which indicates rather that drug-induced lupus may explain at least some cases of new pleural effusions following the initiation of isoniazid.
authors: Department of Occupational and Environmental Medicine, University of California, San Francisco, 350 Parnassus Avenue, Room 609, San Francisco, CA 94143-0924, USA. Paul.Blanc@ucsf.edu.
authors: Vanja
authors: V
authors: Varenika
authors: Paul D
authors: PD
authors: Blanc