title: Enantioselective one-pot conjugate addition of grignard reagents to cyclic enones followed by amidomethylation.
abstract: Enantioselective conjugate addition of Grignard reagents to enones, catalyzed by Cu-Taniaphos or Josiphos complex, affords chiral enolates. Ensuing one-pot Mannich reaction with TiCl(4)-generated imine leads to aminocarbonyl compounds with benzyloxycarbonyl-protected nitrogen. Both diastereomers of these compounds are isolated in moderate yields but high enantiomeric purities (up to er 97.5:2.5).
authors: Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH-2, SK-84215 Bratislava, Slovakia.
authors: Filip
authors: F
authors: Bilčík
authors: Michal
authors: M
authors: Drusan
authors: Jozef
authors: J
authors: Marák
authors: Radovan
authors: R
authors: Šebesta