title: Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis.
abstract: OBJECTIVE
  There is evidence that both environmental and genetic factors contribute to pelvic organ prolapse. We conducted a genome-wide association study to investigate whether common genetic variants modify the risk of pelvic organ prolapse.
  
  
  METHODS
  We recruited women who had been evaluated and treated for pelvic organ prolapse at the University of Utah from 1996 to 2008 and their affected female relatives. Those in the case group were genotyped on the Illumina 550K platform. We genetically matched 2,976 white control participants available from Illumina as the control group. Association tests were adjusted for related participants using two different software programs: EMMAX and Genie. Confirmation of findings was performed in a cohort of Dutch women (n=76) with recurrent pelvic organ prolapse and family history of pelvic organ prolapse.
  
  
  RESULTS
  The Utah study sample included 115 case group participants treated for pelvic organ prolapse, in most case group participants with surgery (n=78) or repeat surgery (n=35). Results from association analyses using EMMAX software identified five single-nucleotide polymorphisms (SNPs) significantly associated with pelvic organ prolapse (P<1×10). Independent association analysis with Genie software identified three of the same SNPs and one additional SNP. The six SNPs were located at 4q21 (rs1455311), 8q24 (rs1036819), 9q22 (rs430794), 15q11 (rs8027714), 20p13 (rs1810636), and 21q22 (rs2236479). Nominally significant findings (P<.05) or findings trending toward significance (P<.1) were observed for five of the six SNPs in the Dutch cohort.
  
  
  CONCLUSIONS
  Six SNPs have been identified that are significantly associated with pelvic organ prolapse in high-risk familial case group participants and that provide evidence for a genetic contribution to pelvic organ prolapse.
  
  
  METHODS
  II.
authors: From the Departments of Medicine and Obstetrics and Gynecology, University of Utah, and the George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah; the Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre; Nijmegen, the Netherlands; and the Department of Pathology, McGill University/Jewish General Hospital, Montreal, Canada.
authors: Kristina
authors: K
authors: Allen-Brady
authors: Lisa
authors: L
authors: Cannon-Albright
authors: James M
authors: JM
authors: Farnham
authors: Craig
authors: C
authors: Teerlink
authors: Mark E
authors: ME
authors: Vierhout
authors: Léon C L
authors: LCL
authors: van Kempen
authors: Kirsten B
authors: KB
authors: Kluivers
authors: Peggy A
authors: PA
authors: Norton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D015894:Genome, Human; D006801:Humans; D008875:Middle Aged; D009426:Netherlands; D056887:Pelvic Organ Prolapse / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014589:Utah; D044465:White People; D055815:Young Adult