title: Optimal antiretroviral therapy for aging.
abstract: The introduction of highly active antiretroviral therapy (HAART) has irrevocably changed the nature of the HIV epidemic in developed countries. Although the use of HAART does not completely restore health in HIV-infected individuals, it has dramatically reduced morbidity and mortality. Increases in life expectancy resulting from effective long-term treatment mean that the proportion of older people living with HIV has increased substantially in the past 15 years. Increasing age is associated with many complications including cardiovascular disease, neurological complications, kidney and liver dysfunction, and metabolic complications such as dyslipidaemia and diabetes. HIV infection and antiretroviral drugs have also been associated with similar complications to those seen with increasing age. The increase in HIV prevalence in older age groups has not been accompanied by the development of treatment guidelines or recommendations for appropriate antiretroviral therapy or clinical management in these patients.
authors: The Kirby Institute, University of New South Wales, Sydney, NSW 2010, Australia.
authors: Damien V
authors: DV
authors: Cordery
authors: David A
authors: DA
authors: Cooper
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D006299:Health Services for the Aged / Q000458:organization & administration; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology; D009422:Nervous System Diseases / Q000453:epidemiology; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D019380:Anti-HIV Agents