title: Insights into human endometrial receptivity from transcriptomic and proteomic data.
abstract: The appreciation of endometrial receptivity is a crucial step in assisted reproductive technology as implantation failures are thought to result, in large part, from abnormal endometrial receptivity. Using emerging omics technologies, investigators have begun to define both molecular signatures and specific biomarkers of receptive endometrium. The aim of this review was to analyse the new perspectives brought to the appreciation of endometrial receptivity by transcriptomic and proteomic technologies, involving the analysis of gene- or protein-expression-profile shifts between the pre-receptive and receptive secretory stages and how they might lead to new strategies for endometrial receptivity assessments. The use of omics as molecular tools to determine the effects of stimulation protocols on endometrial gene expression and clinical outcomes has also been investigated.
authors: CHU Montpellier, Institut de Recherche en Biothérapie, INSERM U847, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, F-34295 Montpellier cedex 5, France.
authors: Delphine
authors: D
authors: Haouzi
authors: Hervé
authors: H
authors: Dechaud
authors: Said
authors: S
authors: Assou
authors: John
authors: J
authors: De Vos
authors: Samir
authors: S
authors: Hamamah
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D010641:Phenotype; D011247:Pregnancy; D040901:Proteomics / Q000379:methods*; D014158:Transcription, Genetic
chemical_list: D015415:Biomarkers