title: Biopolymeric nifedipine powder for acceleration of wound healing.
abstract: Nine biodegradable polymeric powders of chitosan; with or without gelatin; containing nifedipine (NF), were prepared via spray drying for acceleration of wound healing. The angle of repose of powders ranged from 30° to 40° for F(3) and chitosan/gelatin (C(2)), respectively. Upon spray drying, the mean particle size (PS) of chitosan was greatly reduced from 294 to 3.4 μm, while all formulae showed a PS near 3 μm. Specific surface area of the powders ranged from 0.06 × 10(5) to 2.03 × 10(5)cm(2)g. Powders exposure to glutraldehyde (GA) vapors gave smaller particles with higher densities with F(4) showing a mean PS of 0.4 μm. NF dissolution pattern in PBS, was highest from F(2) with 33% released after 30 min while F(3) showed only 4.5% NF released after the same period. Exposure to GA showed a reduction in NF release especially with F(5) showing 30% release after 3h. Tensile strength of 12 days-post incision wound in rats showed a maximum value of 4.7 kg cm(-2) for F(3) compared with 3.3 kg cm(-2) for the control. Excision wounds treated with F(3) also showed a fully developed epithelium with normal keratinization, and an average wound contraction of 99% compared with 79.5% for the control.
authors: Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Azarita, El-Khartom Sq. 21521, Alexandria, Egypt. wsamy73@yahoo.com
authors: Wael
authors: W
authors: Samy
authors: Nazik
authors: N
authors: Elgindy
authors: Hanan M
authors: HM
authors: El-Gowelli
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004339:Drug Compounding; D005260:Female; D005780:Gelatin / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009543:Nifedipine / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011208:Powders; D005780:Gelatin; D048271:Chitosan; D009543:Nifedipine