title: Diet and exercise improve neutrophil to lymphocyte ratio in overweight adolescents.
abstract: Neutrophil to lymphocyte ratio and levels of pro-inflammatory cytokines were evaluated in overweight, male Chinese adolescents upon completing a 4-week diet and physical exercise intervention. 43 recruited, non-randomized adolescents (body mass index >25 kg/m2) completed the controlled study. Anthropometric and biologic parameters were measured pre- and post-intervention. After the 4-week intervention, participants exhibited a significant decrease in body mass, body mass index, percentage body fat, basal heart rate, diastolic blood pressure, and all body shape indices tested. A significant decrease in serum lipids (except high-density lipoprotein cholesterol) and insulin levels was observed post-intervention. The neutrophil to lymphocyte ratio was significantly lower post-intervention. Bivariate correlation analyses showed that decrement in Δneutrophil to lymphocyte ratio significantly correlated with decrement in Δinterleukin-6 and Δwhite blood cell count. Thus, a 4-week diet and physical exercise intervention significantly reduces the neutrophil to lymphocyte ratio in a population of overweight, male adolescents. Weight loss caused by the intervention was associated with a significant decrease of pro-inflammatory cytokine levels.
authors: Shanghai University of Sport, Department of Sports Medicine, Shanghai, China.
authors: R
authors: R
authors: Wang
authors: P J
authors: PJ
authors: Chen
authors: W H
authors: WH
authors: Chen
mesh_terms: D054392:Adipokines; D000293:Adolescent; D000367:Age Factors; D000886:Anthropometry; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D004032:Diet; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D015999:Multivariate Analysis; D009504:Neutrophils / Q000276:immunology*; D009752:Nutritional Status; D050177:Overweight / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D054392:Adipokines; D015850:Interleukin-6; D002097:C-Reactive Protein