title: Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets.
abstract: Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.
authors: Laboratoire M.E.R.C.I - EA 3829, Faculté de Médecine et de Pharmacie, Université de Rouen, Rouen, France. caroline.gest@yahoo.fr
authors: Caroline
authors: C
authors: Gest
authors: Pezhman
authors: P
authors: Mirshahi
authors: Hong
authors: H
authors: Li
authors: Linda-Louise
authors: LL
authors: Pritchard
authors: Ulrich
authors: U
authors: Joimel
authors: Emmanuel
authors: E
authors: Blot
authors: Jean
authors: J
authors: Chidiac
authors: Bernard
authors: B
authors: Poletto
authors: Jean-Pierre
authors: JP
authors: Vannier
authors: Remi
authors: R
authors: Varin
authors: Massoud
authors: M
authors: Mirshahi
authors: Lionel
authors: L
authors: Cazin
authors: Eric
authors: E
authors: Pujade-Lauraine
authors: Jeannette
authors: J
authors: Soria
authors: Claudine
authors: C
authors: Soria
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015153:Blotting, Western; D002460:Cell Line; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D006801:Humans; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D014407:Tumor Cells, Cultured; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D050796:STAT3 Transcription Factor; D017526:Receptor, IGF Type 1; D020742:rhoA GTP-Binding Protein