title: Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.
abstract: Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.
authors: Trudeau Institute, Saranac Lake, New York, USA.
authors: Irah L
authors: IL
authors: King
authors: Anne
authors: A
authors: Fortier
authors: Michael
authors: M
authors: Tighe
authors: John
authors: J
authors: Dibble
authors: Gerald F M
authors: GF
authors: Watts
authors: Natacha
authors: N
authors: Veerapen
authors: Ann M
authors: AM
authors: Haberman
authors: Gurdyal S
authors: GS
authors: Besra
authors: Markus
authors: M
authors: Mohrs
authors: Michael B
authors: MB
authors: Brenner
authors: Elizabeth A
authors: EA
authors: Leadbetter
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology; D056724:Immunity, Humoral; D007156:Immunologic Memory; D007378:Interleukins / Q000502:physiology*; D008055:Lipids / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055611:Natural Killer T-Cells / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013154:Spleen / Q000276:immunology; D000098546:Interleukin-21
chemical_list: D000941:Antigens; D007378:Interleukins; D008055:Lipids; D011947:Receptors, Antigen, B-Cell; D000098546:Interleukin-21