title: Intermittent simulated moving bed chromatography: 3. Separation of Tröger's base enantiomers under nonlinear conditions.
abstract: One of the modified simulated moving bed (SMB) processes, the intermittent SMB (I-SMB) process, has been recently analyzed theoretically [1] and its superior performance compared to the conventional SMB process has been demonstrated at a rather low total feed concentration through experiments and simulations [2]. This work shows that the I-SMB process outperforms the conventional SMB process also at high feed concentration where the species are clearly subject to a nonlinear adsorption isotherm. In the case of the separation of the Tröger's base's enantiomers in ethanol on ChiralPak AD, the two processes operated in a six-column 1-2-2-1 configuration (one column in sections 1 and 4 and two columns in sections 2 and 3) and in a four-column 1-1-1-1 configuration (one column in each section) are compared at high feed concentration through both experiments and simulations. Even under nonlinear conditions the four column I-SMB process can successfully separate the two enantiomers achieving purity levels as high as the two six column processes and exhibiting better productivity.
authors: Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
authors: Shigeharu
authors: S
authors: Katsuo
authors: Christian
authors: C
authors: Langel
authors: Anne-Laure
authors: AL
authors: Sandré
authors: Marco
authors: M
authors: Mazzotti
mesh_terms: D000327:Adsorption; D001392:Azocines / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D008956:Models, Chemical; D017711:Nonlinear Dynamics; D013237:Stereoisomerism
chemical_list: D001392:Azocines; C083830:Troeger's base