title: Adenocarcinoma of the urinary bladder.
abstract: Primary adenocarcinoma of urinary bladder is an uncommon neoplasm and is a source of diagnostic confusion with adenocarcinomas arising in adjacent organs, especially colon. These tumors show varied histologic picture and degree of differentiation. Clinical association with bladder exstrophy and schistosomiasis has been well documented. Primary bladder adenocarcinomas have overlapping histologic and immunohistochemical features with adenocarcinomas arising from other primary sites and the suggested immunohistochemical panel includes cytokeratins 7 and 20, 34βE12, thrombomodulin, CDX2, and β-catenin. Clinical, imaging, histologic, and immunohistochemical correlation should be done while rendering this diagnosis, as prognosis and therapeutic options for primary versus metastatic adenocarcinoma vary widely.
authors: Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15261, USA. roys911@gmail.com
authors: Somak
authors: S
authors: Roy
authors: Anil V
authors: AV
authors: Parwani
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20 / Q000378:metabolism; D053552:Keratin-7 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D018180:Thrombomodulin / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; C121278:CK-34 beta E12; C495270:CTNNB1 protein, human; D018398:Homeodomain Proteins; D053554:Keratin-20; D053552:Keratin-7; D008840:Microfilament Proteins; C546931:THBD protein, human; D018180:Thrombomodulin; D051176:beta Catenin; C026615:villin; D007633:Keratins