title: The involvement of PPARs in the causes, consequences and mechanisms for correction of cardiac lipotoxicity and oxidative stress.
abstract: Chronically-elevated plasma lipid concentrations, particularly when combined with high glucose, elicit a plethora of effects that cause the progressive deterioration of insulin sensitivity and ultimately cellular malfunction or death. This review addresses how metabolic abnormalities in white adipose tissue leading to excessive lipid or abnormal adipokine release can be modified by PPARγ activation. It also discusses the etiology of cardiac lipotoxicity and oxidative stress, in relation to imbalanced lipid delivery and clearance and how PPARα activation can be used to correct some of these effects.
authors: Centre for Diabetes, Blizard Institute, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK. m.c.sugden@qmul.ac.uk
authors: M C
authors: MC
authors: Sugden
authors: M P
authors: MP
authors: Warlow
authors: M J
authors: MJ
authors: Holness
mesh_terms: D054392:Adipokines / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D024821:Metabolic Syndrome / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D047493:PPAR alpha / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism
chemical_list: D054392:Adipokines; D047493:PPAR alpha; D047495:PPAR gamma; D017382:Reactive Oxygen Species; D056564:Sirtuin 1