title: A child with BK virus infection: inadequacy of current therapeutic strategies.
abstract: In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.
authors: Division of Pediatric Nephrology, Department of Pediatrics, Holtz Children's Hospital, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
authors: Tanya
authors: T
authors: Pereira
authors: Claudia P
authors: CP
authors: Rojas
authors: Monica T
authors: MT
authors: Garcia-Buitrago
authors: Jayanthi
authors: J
authors: Chandar
authors: Carolyn
authors: C
authors: Abitbol
authors: Wacharee
authors: W
authors: Seeherunvong
authors: Paolo
authors: P
authors: Rusconi
authors: Jocelyn H
authors: JH
authors: Bruce
authors: Gaston
authors: G
authors: Zilleruelò
mesh_terms: D001739:BK Virus / Q000235:genetics*; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology; D009202:Cardiomyopathies / Q000628:therapy; D002648:Child; D000077404:Cidofovir; D003596:Cytosine / Q000009:adverse effects / Q000031:analogs & derivatives; D004679:Encephalomyelitis / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007668:Kidney / Q000821:virology*; D007674:Kidney Diseases / Q000209:etiology / Q000821:virology*; D063065:Organophosphonates / Q000009:adverse effects; D016133:Polymerase Chain Reaction / Q000379:methods; D027601:Polyomavirus Infections / Q000150:complications* / Q000628:therapy; D019562:Viral Load
chemical_list: D007166:Immunosuppressive Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir