title: Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.
abstract: At present, many patients are medicated with various drugs, which are, at the same time, associated with an increased risk of drug-drug interactions (DDIs). Detailed analysis of mechanisms underlying DDIs is the basis of a better prediction of adverse drug events caused by drug interactions. In the last few decades, an involvement of transporters in such processes has been more and more recognized. Indeed, uptake transporters belonging to the organic anion-transporting polypeptide (OATP) family have been shown to interact with a variety of drugs in clinical use. Particularly, the subfamily of OATP1B transporters has been extensively studied, identifying several clinical significant DDIs based on those hepatic uptake transporters. By contrast, the role of OATP2B1 in this context is rather underestimated. Therefore, in addition to known interactions based on OATP1B transporters, we have focused on DDIs probably based on OATP2B1 inhibition in the liver and those possibly owing to the inhibition of OATP2B1-mediated drug absorption in the intestine.
authors: Institute of Pharmacology, Ernst Moritz Arndt University, Friedrich-Loeffler-Straße 23, 17487 Greifswald, Germany.
authors: Anna
authors: A
authors: Koenen
authors: Heyo K
authors: HK
authors: Kroemer
authors: Markus
authors: M
authors: Grube
authors: Henriette E
authors: HE
authors: Meyer zu Schwabedissen
mesh_terms: D000818:Animals; D004347:Drug Interactions / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D005810:Multigene Family / Q000235:genetics / Q000502:physiology; D027361:Organic Anion Transporters / Q000235:genetics / Q000502:physiology*
chemical_list: D027361:Organic Anion Transporters