title: A simple parallel gas chromatography column screening system.
abstract: A simple approach to the automated screening of four different columns on a single gas chromatography (GC) instrument is used for rapid chiral GC method development. Configuration of a conventional GC instrument with a second autosampler and several inexpensive Y-splitters enables simultaneous evaluation of two different columns, allowing a total of four different columns to be evaluated in two automated back to back runs. The resulting system affords a simple and effective approach to chiral GC method development that speeds analysis while eliminating the need for slow and tedious manual interchange of columns. An example of developing a rapid isothermal GC method from the screening results obtained by the instrument is also shown.
authors: Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors: Wes
authors: W
authors: Schafer
authors: Simon E
authors: SE
authors: Hamilton
authors: Zainab
authors: Z
authors: Pirzada
authors: Christopher J
authors: CJ
authors: Welch
mesh_terms: D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D013237:Stereoisomerism