title: HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
abstract: OBJECTIVE
  To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM).
  
  
  METHODS
  During 2003-2004, women undergoing a 75 g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8 mmol/L. 1-2 years after delivery a 75 g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects.
  
  
  RESULTS
  HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance.
  
  
  CONCLUSIONS
  Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development.
authors: Department of Clinical Sciences, Lund University, Malmö, Sweden. Anastasia.Papadopoulou@med.lu.se
authors: Anastasia
authors: A
authors: Papadopoulou
authors: Kristian F
authors: KF
authors: Lynch
authors: Eva
authors: E
authors: Anderberg
authors: Mona
authors: M
authors: Landin-Olsson
authors: Ida
authors: I
authors: Hansson
authors: Carl-David
authors: CD
authors: Agardh
authors: Åke
authors: Å
authors: Lernmark
authors: Kerstin
authors: K
authors: Berntorp
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005951:Glucose Tolerance Test; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000276:immunology*; D059866:HLA-DQ beta-Chains / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D049590:Postpartum Period / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D013548:Sweden / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; C096322:ICA512 autoantibody; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2