title: Geographic structuring of global EIAV isolates: a single origin for New World strains?
abstract: Equine infectious anaemia virus (EIAV) is classified within the Retroviridae and, like other lentivirus, has the propensity for considerable antigenic variation. An extensive phylogenetic analysis in Bayesian fashion, with significant amounts of new EIAV gag sequence information, revealed a strong geographic compartmentalization clearly related to the phylogeographic history of modern horses, pointing out that New World EIAV strains form a distinct group with a potentially common origin. This evidence suggests that a single founder event may have occurred during the reintroduction of horses to the Americas by European colonists in the 15th century, a possibility that raises many interesting scenarios with implications for all evolutionary and ecological studies.
authors: Centro di Studio del Cavallo Sportivo, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy. capemaster@gmail.com
authors: Stefano
authors: S
authors: Capomaccio
authors: Katia
authors: K
authors: Cappelli
authors: R Frank
authors: RF
authors: Cook
authors: Francesco
authors: F
authors: Nardi
authors: Robert
authors: R
authors: Gifford
authors: Maria Luisa
authors: ML
authors: Marenzoni
authors: Fabrizio
authors: F
authors: Passamonti
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004859:Equine Infectious Anemia / Q000453:epidemiology* / Q000821:virology*; D015683:Gene Products, gag / Q000235:genetics; D014943:Global Health; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D017720:Molecular Epidemiology; D058974:Phylogeography; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D015683:Gene Products, gag