title: The amount of TMJ displacement correlates with brain activity.
abstract: The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the correlation between the severity of malocclusion and brain activation. The fMRI was used to measure blood-oxygenation- level-dependent (BOLD) signals of twelve healthy human subjects while they clenched in two different ways to simulate two types of malocclusion. In each malocclusion model, a custom-made splint forced the mandible to each of two retrusive positions (0.5 mm, 0.7 mm). A no-modification splint provided the control. We compared the BOLD signals measured at each clenching position with those measured during the corresponding resting conditions. The BOLD signals were significantly stronger in the amygdala and the prefrontal area (PFA) when subjects clenched in the two retrusive positions compared during clenching in the control position. In addition, the BOLD signal in the PFA increased as the simulated malocclusion became more severe. These results indicate that we may be able to objectively assess the severity of malocclusion via focus on the brain activity.
authors: Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College.
authors: Markus
authors: M
authors: Greven
authors: Takero
authors: T
authors: Otsuka
authors: Leander
authors: L
authors: Zutz
authors: Bernd
authors: B
authors: Weber
authors: Christian
authors: C
authors: Elger
authors: Sadao
authors: S
authors: Sato
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002531:Cerebellum / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D003287:Contrast Media; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008310:Malocclusion / Q000473:pathology / Q000503:physiopathology*; D008335:Mandibular Condyle / Q000473:pathology; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D013705:Temporomandibular Joint Disorders / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D010100:Oxygen