title: Few changes observed in polysomnographic-assessed sleep before and after completion of chemotherapy.
abstract: OBJECTIVE
  Sleep disturbance is prevalent among patients undergoing chemotherapy and is strongly associated with cancer-related fatigue (CRF). However, little objective evidence has been gathered on the patterns of sleep before and following chemotherapy.
  
  
  METHODS
  Twenty-six patients scheduled to receive chemotherapy were recruited. Sleep parameters were assessed by in-lab polysomnography (PSG) for two consecutive nights prior to first chemotherapy, approximately 3weeks following the patients' last chemotherapy, and 3months following the last treatment. Fatigue was measured on the first night of each of the two-night PSG assessments. We focus on Slow-Wave Sleep (SWS) as we hypothesized that a decrease of this restorative phase of sleep might be implicated in CRF.
  
  
  RESULTS
  Repeated-measures analyses examining changes from baseline to the later time points in the proportion of time asleep spent in each of the four sleep architecture stages (Stage 1, Stage 2, SWS, and REM sleep) were non-significant, all Ps>0.41. Canonical correlation analysis showed that the proportion of time spent in SWS was not significantly correlated with any of the three CRF measures at any of the three assessment points, P=0.28.
  
  
  CONCLUSIONS
  Sleep architecture is not affected by cancer treatment. No evidence of an association between CRF and SWS, or alterations in SWS, was found.
authors: University of Rochester James P. Wilmot Cancer Center, Rochester, NY 14642, United States. Joseph_Roscoe@urmc.rochester.edu
authors: Joseph A
authors: JA
authors: Roscoe
authors: Michael L
authors: ML
authors: Perlis
authors: Wilfred R
authors: WR
authors: Pigeon
authors: Kristen H
authors: KH
authors: O'Neill
authors: Charles E
authors: CE
authors: Heckler
authors: Sara E
authors: SE
authors: Matteson-Rusby
authors: Oxana G
authors: OG
authors: Palesh
authors: Michelle
authors: M
authors: Shayne
authors: Alissa
authors: A
authors: Huston
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017286:Polysomnography; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000503:physiopathology*