title: Expression analysis of high mobility group box-1 protein (HMGB-1) in the cerebral cortex, hippocampus, and cerebellum of the congenital hydrocephalus (H-Tx) rat.
abstract: High mobility group box-1 protein (HMGB-1), a protein expressed highly in developing neurons, is involved in the development and differentiation of neurons. At the same time, it functions as a transcriptional regulator of particular genes and as a cytokine: HMGB-1 released from a defective cell has been reported to induce damage to the adjacent cells.With a view to examine the relationship between neuronal damage caused by hydrocephalus and HMGB-1, we analyzed the expression of HMGB-1 in the cerebellum, cerebrum, and hippocampus of 1-day-old congenitally hydrocephalic H-Tx rats.As opposed to nonhydrocephalic H-Tx rats, the hydrocephalic H-Tx rats were observed to show stronger expression of HMGB-1 in the cerebellum, cerebrum, and hippocampus. Consequently, the protein was presumed to influence the development of neurons from an early postnatal stage not only in the cerebral cortex and hippocampus but also in the cerebellum, which is less susceptible to the direct effects of hydrocephalus. We expect that, in the future, regulating the expression or functions of HMGB-1 will lead to the possibility of impeding the progress of neuronal damage caused by hydrocephalus.
authors: Department of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, Japan. mitsuya.med-juntendo@tamanan-hp.com
authors: Mitsuya
authors: M
authors: Watanabe
authors: Masakazu
authors: M
authors: Miyajima
authors: Madoka
authors: M
authors: Nakajima
authors: Hajime
authors: H
authors: Arai
authors: Ikuko
authors: I
authors: Ogino
authors: Sinji
authors: S
authors: Nakamura
authors: Miyuki
authors: M
authors: Kunichika
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006849:Hydrocephalus / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains
chemical_list: D024243:HMGB1 Protein; C104200:Hbp1 protein, rat; D012333:RNA, Messenger