title: A-kinase anchoring proteins as potential drug targets.
abstract: A-kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales. In particular, AKAPs mediate compartmentalization of cAMP signalling. Alterations in AKAP expression and their interactions are associated with or cause diseases including chronic heart failure, various cancers and disorders of the immune system such as HIV. A number of cellular dysfunctions result from mutations of specific AKAPs. The link between malfunctions of single AKAP complexes and a disease makes AKAPs and their interactions interesting targets for the development of novel drugs. LINKED ARTICLES This article is part of a themed section on Novel cAMP Signalling Paradigms. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.166.issue-2.
authors: Max Delbrück Center for Molecular Medicine Berlin-Buch (MDC), Berlin, Germany Leibniz Institute for Molecular Pharmacology (FMP), Berlin, Germany.
authors: Jessica
authors: J
authors: Tröger
authors: Marie C
authors: MC
authors: Moutty
authors: Philipp
authors: P
authors: Skroblin
authors: Enno
authors: E
authors: Klussmann
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D015195:Drug Design; D006801:Humans; D015398:Signal Transduction
chemical_list: D054758:A Kinase Anchor Proteins