title: Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation.
abstract: The role of pulmonary rehabilitation (PR) in COPD patients with lung hyperinflation has not yet been fully investigated. We retrospectively evaluated the effect of a standard PR course on exercise tolerance and symptoms according to the presence or absence of associated lung hyperinflation, as defined by lung function parameters in three Italian rehabilitation centres. In a cohort of 823 COPD patients (age 71 ± 8 years, FEV1 56 ± 18% pred.) we have systematically recorded: changes (∆) in 6-minute walking test (6MWD) as the primary outcome; dyspnoea (D); muscle fatigue (F); SO2nadir during effort; perceived breathlessness score (MRC); and specific health-related quality of life (SGRQ). Outcomes were compared between patients with lung hyperinflation (n = 283, LH) or without (n = 540 No-LH). Groups were comparable for age, body mass index, baseline exercise tolerance, and breathlessness. ∆-6MWD (+72 ± 47 vs. +62 ± 42 m, p < 0.05); ∆-D (-2.3 ± 1.7 vs. -1.9 ± 1.3 point, p < 0.05) and ∆-SO2nadir (+1.4 ± 3.0 and +0.5 ± 3.3 point, p < 0.05) were greater in LH than in No-LH. Using a multivariate linear regression model, ∆-6MWD in the LH group significantly correlated with lower functional residual capacity (p = 0.021) and baseline 6MWD (p = 0.004). Tolerance, gas exchange and perceived symptoms during effort are the parameters that gain a significant benefit from standard rehabilitation in COPD patients with a lung hyperinflation condition.
authors: Pulmonary Rehabilitation, Villa Pineta Hospital, 41026, Pavullo (MO), Italy, crisafulli.ernesto@villapineta.it.
authors: Ernesto
authors: E
authors: Crisafulli
authors: Elena
authors: E
authors: Venturelli
authors: Gianluca
authors: G
authors: Biscione
authors: Guido
authors: G
authors: Vagheggini
authors: Andrea
authors: A
authors: Iattoni
authors: Sasha
authors: S
authors: Lucic
authors: Nicolino
authors: N
authors: Ambrosino
authors: Franco
authors: F
authors: Pasqua
authors: Alfredo
authors: A
authors: Cesario
authors: Enrico Maria
authors: EM
authors: Clini
mesh_terms: D000368:Aged; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000534:rehabilitation*; D011659:Pulmonary Gas Exchange; D012189:Retrospective Studies