title: Family-based association study of chromosome 6p12.2-p21.1 migraine locus.
abstract: BACKGROUND
  One of the genome-wide linkage studies performed in migraine has yielded a significant linkage of migraine (with and without aura) with markers located at 6p12.2-21.1. This locus (named MIGR3) has not been replicated in the only genome-wide association scan study performed to date or in previous genome-wide linkage studies.
  
  
  OBJECTIVE
  Our objective had been to replicate the MIGR3 locus performing a family-based association study.
  
  
  METHODS
  A sample of 594 subjects belonging to 134 migraine families of diverse complexity underwent genotyping for the markers previously published as linked at 6p12.2-21.1 migraine locus. Family-based association test, under different models of inheritance, and also the model-free TDT analysis were performed.
  
  
  RESULTS
  The best result was obtained with the D6S1650 marker under the additive model (rank [S observed] = 265.0; permuted P = .0006), using family-based association test program (HBAT subprogram). Similar results were obtained with the model-free TDTPHASE algorithm (P < .0001, corrected). Nominal significant P values were obtained for D6S1630, D6S452, and D6S257. After correction for multiple testing with the stratified false-discovery rate, all markers showed significant association (P < .0001).
  
  
  CONCLUSIONS
  We corroborated that the MIGR3 locus at 6p12 is a genetic risk for migraine with and without aura.
authors: University Hospital Marques de Valdecilla-Neurology, Santander, Cantabria, Spain. oterino@telefonica.net
authors: Agustín
authors: A
authors: Oterino
authors: Maria
authors: M
authors: Toriello
authors: Jesus
authors: J
authors: Castillo
authors: Vicente
authors: V
authors: González-Quitanilla
authors: Pablo
authors: P
authors: Sánchez-Velasco
authors: Ana
authors: A
authors: Alonso
authors: Nuria
authors: N
authors: Ruiz-Lavilla
authors: Julio
authors: J
authors: Pascual
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005192:Family Health; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D055815:Young Adult
chemical_list: D005819:Genetic Markers