title: [Thrombin generation test at physiological and risk gravidity].
abstract: Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF/FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF/FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.
  
  
  METHODS
  Review.
  
  
  METHODS
  Department of Obstetrics and Gynecology, University Hospital Olomouc.
authors: Porodnicko-gynekologická klinika FN, Olomouc.
authors: V
authors: V
authors: Lattová
authors: M
authors: M
authors: Procházka
authors: J
authors: J
authors: Ulehlová
mesh_terms: D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000175:diagnosis; D013917:Thrombin / Q000032:analysis*
chemical_list: D013917:Thrombin