title: Tumorigenesis related to retroviral infections.
abstract: Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.
authors: University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece. mbraouda@yahoo.co.uk
authors: Maria
authors: M
authors: Braoudaki
authors: Fotini
authors: F
authors: Tzortzatou-Stathopoulou
mesh_terms: D002472:Cell Transformation, Viral; D003906:Developing Countries; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology*; D012190:Retroviridae / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000150:complications* / Q000453:epidemiology*