title: Studies on the constituents of Lagochilus leiacanthus (Labiatae).
abstract: Two flavanones, 5,2',6'-trihydroxy-7,8-dimethoxyflavanone (1), 5,2',6'-trihydroxy-6,7,8-trimethoxyflavanone (2) and their 2'-O-β-D-glucosides (3, 4), and a neoclerodane-type diterpene, 15-demethoxyscupolin I (5), together with twenty-eight known compounds were isolated from the extracts of Lagochilus leiacanthus. The structures of the new compounds were determined by spectroscopic means. The two new flavanones and some known flavonoids showed the inhibitory activity on the release of β-hexosaminidase from RBL-2H3 cells.
authors: School of Pharmacy, Nihon University, Funabashi, Chiba 274–8555, Japan.
authors: Megumi
authors: M
authors: Furukawa
authors: Hideya
authors: H
authors: Suzuki
authors: Mitsuko
authors: M
authors: Makino
authors: Shoujiro
authors: S
authors: Ogawa
authors: Takashi
authors: T
authors: Iida
authors: Yasuo
authors: Y
authors: Fujimoto
mesh_terms: D000818:Animals; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D051381:Rats; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D044950:Flavanones; D005419:Flavonoids; D001619:beta-N-Acetylhexosaminidases