title: Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane.
abstract: In this study, a three-dimensional finite-element model of the passive human cochlea was created. Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with the cochlear fluid. Next, the effects of a perilymphatic fistula (PLF) on the vibration of the cochlea were examined by making a small hole on the wall of the cochlea model. Even if a PLF existed in the scala vestibuli, a traveling wave was generated on the basilar membrane. When a PLF existed at the basal end of the cochlea, the shape of the traveling wave envelope showed no remarkable change, but the maximum amplitude became smaller at the entire frequency range from 0.5 to 5kHz and decreased with decreasing frequency. In contrast, when a PLF existed at the second turn of the cochlea, the traveling wave envelope showed a notch at the position of the PLF and the maximum amplitude also became smaller. This model assists in elucidating the mechanisms of hearing loss due to a PLF from the view of dynamics.
authors: Department of Mechanical Engineering and Intelligent Systems, Graduate School of Informatics and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan. koike@mce.uec.ac.jp
authors: Takuji
authors: T
authors: Koike
authors: Chiaki
authors: C
authors: Sakamoto
authors: Tasuku
authors: T
authors: Sakashita
authors: Ken
authors: K
authors: Hayashi
authors: Sho
authors: S
authors: Kanzaki
authors: Kaoru
authors: K
authors: Ogawa
mesh_terms: D001489:Basilar Membrane / Q000473:pathology / Q000503:physiopathology*; D003198:Computer Simulation; D020342:Finite Element Analysis; D005402:Fistula / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007759:Labyrinth Diseases / Q000473:pathology / Q000503:physiopathology*; D040542:Mechanotransduction, Cellular; D008953:Models, Anatomic; D010498:Perilymph; D011312:Pressure; D013199:Stapes / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014732:Vibration