title: When oxygen runs short: the microenvironment drives host-pathogen interactions.
abstract: Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.
authors: Institute of Medical Microbiology and Hygiene, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
authors: Inga
authors: I
authors: Dietz
authors: Stefan
authors: S
authors: Jerchel
authors: Márta
authors: M
authors: Szaszák
authors: Kensuke
authors: K
authors: Shima
authors: Jan
authors: J
authors: Rupp
mesh_terms: D056704:Adaptive Immunity; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D015687:Cell Hypoxia; D060833:Cellular Microenvironment; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D010101:Oxygen Consumption
chemical_list: D000890:Anti-Infective Agents