title: Foslip®-based photodynamic therapy as a means to improve wound healing.
abstract: BACKGROUND
  Collagen matrices as substitution for connective tissue are known to promote wound healing. Photodynamic therapy has been anecdotally associated with improved wound healing and reduced scarring. The present study investigates the impact of collagen based scaffolding material, embedded with a liposomal formulation of meta-tetra (hydroxyphenyl) chlorin (mTHPC, Foslip(®)) and photodynamic therapy on wound healing in mice.
  
  
  METHODS
  After incision in the neck region, two different types of collagen material, previously incubated with Foslip(®) at different concentrations, were implanted followed by illumination at 652nm (10J/cm(2), 100mW/cm(2)). Mice were imaged daily up to two weeks, whereafter excision was performed and pathological analysis.
  
  
  RESULTS
  Scab detachment was observed at day seven for controls whereas it occurred as early as three days for PDT at the lowest concentrations. In the latter conditions, final matrix remodelling could be observed as evidenced by elastin neosynthesis.
  
  
  CONCLUSIONS
  Topical application of low dose Foslip(®) in a collagen matrix followed by illumination considerably accelerates wound healing.
authors: Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, 6 avenue de Bourgogne 54511 Vandœuvre-lès-Nancy, France. j.garrier@nancy.unicancer.fr
authors: Julie
authors: J
authors: Garrier
authors: Lina
authors: L
authors: Bezdetnaya
authors: Catherine
authors: C
authors: Barlier
authors: Susanna
authors: S
authors: Gräfe
authors: François
authors: F
authors: Guillemin
authors: Marie-Ange
authors: MA
authors: D'Hallewin
mesh_terms: D000818:Animals; D005260:Female; D008652:Mesoporphyrins / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin