title: A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene.
abstract: Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.
authors: Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland. andreas.papas@unibas.ch
authors: A
authors: A
authors: Papassotiropoulos
authors: E
authors: E
authors: Stefanova
authors: C
authors: C
authors: Vogler
authors: L
authors: L
authors: Gschwind
authors: S
authors: S
authors: Ackermann
authors: K
authors: K
authors: Spalek
authors: B
authors: B
authors: Rasch
authors: A
authors: A
authors: Heck
authors: A
authors: A
authors: Aerni
authors: E
authors: E
authors: Hanser
authors: P
authors: P
authors: Demougin
authors: K-D
authors: KD
authors: Huynh
authors: R
authors: R
authors: Luechinger
authors: M
authors: M
authors: Klarhöfer
authors: I
authors: I
authors: Novakovic
authors: V
authors: V
authors: Kostic
authors: P
authors: P
authors: Boesiger
authors: K
authors: K
authors: Scheffler
authors: D J-F
authors: DJ
authors: de Quervain
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D055771:Serbia; D013557:Switzerland; D014706:Verbal Learning / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins; C479429:CTNNBL1 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D010100:Oxygen