title: Stereodivergency in catalytic asymmetric conjugate addition reactions of glycine (ket)imines.
abstract: Stereodivergent catalytic asymmetric conjugate reactions of glycine (ket)imines with nitroalkenes have been achieved using various chiral catalyst systems derived from a multidentate amino alcohol (1). The stepwise nature of the [3 + 2] cycloaddition reactions of N-metalated azomethine ylides has also been demonstrated by highly enantio- and diastereoselective syntheses of exo-5 and endo-8 from the respective syn-4 and anti-7 conjugate addition products in a one-pot tandem fashion.
authors: Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202, USA.
authors: Hun Young
authors: HY
authors: Kim
authors: Jian-Yuan
authors: JY
authors: Li
authors: Sungkyung
authors: S
authors: Kim
authors: Kyungsoo
authors: K
authors: Oh
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000605:Amino Alcohols / Q000737:chemistry; D002384:Catalysis; D005998:Glycine / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000605:Amino Alcohols; D007097:Imines; D005998:Glycine