title: High prevalence of hirsutism and menstrual disorders in obese adolescent girls and adolescent girls with type 1 diabetes mellitus despite different hormonal profiles.
abstract: OBJECTIVE
  To compare the pubertal development, the hormonal profiles and the prevalence of hirsutism and menstrual disorders in obese adolescent girls and adolescent girls with type 1 diabetes mellitus (T1DM).
  
  
  METHODS
  Data were collected from 96 obese adolescent girls and 78 adolescent girls with T1DM at Tanner stage IV or V, whose ages ranged between 11.9 and 17.9 years.
  
  
  RESULTS
  High prevalence of hirsutism and menstrual disorder was found in the obese adolescent girls (36.5 and 42% respectively) and the adolescent girls with T1DM (21 and 44% respectively). The obese girls were significantly younger at pubarche, thelarche and menarche than the girls with T1DM. Hirsutism in the obese girls and those with T1DM was associated with hyperandrogenaemia and a raised free androgen index (FAI). When the cause of the raised FAI was investigated in both the groups of girls with hirsutism, the raised FAI in the obese girls was due to low serum sex hormone-binding globulin (SHBG) levels. In contrast, the raised FAI of the girls with T1DM and hirsutism was due to hyperandrogenaemia. Menstrual disorders in the T1DM girls were associated also with hyperandrogenaemia unlike obese girls.
  
  
  CONCLUSIONS
  Hirsutism and menstrual disorders are common in obese adolescent girls and adolescent girls with T1DM. Although hyperandrogenaemia is present in both groups of girls, the androgenic profiles of the two groups differ. The hyperandrogenaemia in the obese girls is primarily due to their decreased serum SHBG levels, whereas the hyperandrogenaemia in the girls with T1DM is due to their increased androgen production.
authors: Paediatric Endocrinology and Diabetes Unit, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.
authors: Dinane
authors: D
authors: Samara-Boustani
authors: Ana
authors: A
authors: Colmenares
authors: Caroline
authors: C
authors: Elie
authors: Myriam
authors: M
authors: Dabbas
authors: Jacques
authors: J
authors: Beltrand
authors: Virgile
authors: V
authors: Caron
authors: Claude
authors: C
authors: Ricour
authors: Paul
authors: P
authors: Jacquin
authors: Nadia
authors: N
authors: Tubiana-Rufi
authors: Claire
authors: C
authors: Levy-Marchal
authors: Christine
authors: C
authors: Delcroix
authors: Delphine
authors: D
authors: Martin
authors: Lila
authors: L
authors: Benadjaoud
authors: Evelyne
authors: E
authors: Jacqz Aigrain
authors: Christine
authors: C
authors: Trivin
authors: Kathleen
authors: K
authors: Laborde
authors: Elisabeth
authors: E
authors: Thibaud
authors: Jean-Jacques
authors: JJ
authors: Robert
authors: Michel
authors: M
authors: Polak
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006305:Health Status Indicators; D006628:Hirsutism / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D006728:Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007206:Individuality; D008599:Menstruation Disturbances / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D055442:Metabolome; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence
chemical_list: D006728:Hormones