title: Reduction of β-radiation exposure during preparation of 188Re-labelled Lipiodol for hepatocellular carcinoma treatment.
abstract: Rhenium-188 (188Re) is of widespread interest for treating various diseases because of its attractive physical and chemical properties. The routine preparation of therapeutic doses of 188Re-labelled tracers can result in significant radiation exposure to the operator. We studied the impact of automating the preparation of 188Re-Lipiodol on the radiochemist's exposure, as well as the importance of the model of syringe shielding. To monitor radiation exposure continuously readable electronic personal dosimeters were used. Thermoluminescence dosimeters were fixed to the probable most exposed fingers of the radiochemist during preparation of the radiotracer and during the syringing. Dose rates were measured using a Babyline. Automation of the synthesis reduced personal dose equivalents from 2.60±4.35 to 1.61±1.20 µSv/GBq [Hp(10)] and from 38.37±55.28 to 21.84±16.14 µSv/GBq [Hp(0.07)]. Dose to the extremities was also reduced (-80% for the right hand; -58% for the left one). The Lemer-Pax PSWG syringe shield led to a slightly lower dose to the hands compared with the Medisystem (1.1±0.27 vs. 1.34±0.6 mSv/GBq for the right finger). Automation of the synthesis leads to a significant decrease in radiation exposure to the operator. The Lemer-Pax PSWG syringe shield provides better hand protection than the smaller Medisystem Mediclic.
authors: Department of Nuclear Medicine, Comprehensive Cancer Centre Eugène Marquis, Rennes, France. n.lepareur@rennes.unicancer.fr
authors: Nicolas
authors: N
authors: Lepareur
authors: Sophie
authors: S
authors: Laffont
authors: Valérie
authors: V
authors: Ardisson
authors: Nicolas
authors: N
authors: Noiret
authors: Etienne
authors: E
authors: Garin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000528:radiation effects; D001331:Automation; D001610:Beta Particles / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D004998:Ethiodized Oil / Q000138:chemical synthesis; D005385:Fingers / Q000528:radiation effects; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy; D016273:Occupational Exposure / Q000517:prevention & control*; D011482:Protective Devices; D011832:Radiation Injuries / Q000517:prevention & control*; D011835:Radiation Protection / Q000295:instrumentation*; D011868:Radioisotopes / Q000528:radiation effects; D012211:Rhenium / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D011868:Radioisotopes; D012211:Rhenium; D004998:Ethiodized Oil