title: Effect of a single brushing with two Zn-containing toothpastes on VSC in morning breath: a 12 h, randomized, double-blind, cross-over clinical study.
abstract: This randomized, double-blind, 12 h clinical study tested the effect of a single brushing with two Zn-containing toothpastes on volatile sulfur compound (VSC) levels in morning breath. The following toothpastes were each tested by all 28 participants: A-Zn toothpaste, B--experimental toothpaste (Zn citrate + PVM/MA copolymer) and C--control toothpaste without Zn. The evening prior to test days participants brushed their teeth for 2 min with 1 g toothpaste. 12 h later and prior to eating or performing oral hygiene, morning breath levels of VSC (H(2)S, CH(3)SH) were analysed by gas chromatography. Subjects then rinsed for 30 s with 5 ml cysteine and breath samples were analysed for H(2)S (H(2)S(cys)). Median VSC (area under the curve) values were compared for A, B and C and the effects of A and B on VSC were compared with C. Toothpaste B was more effective than both toothpastes A and C in reducing H(2)S, CH(3)SH and H(2)S(cys) (p < 0.05). Compared with toothpaste C, toothpastes A and B reduced H(2)S by 35% and 68%, respectively (p = 0.003), and CH(3)SH by 12% and 47%, respectively (p = 0.002). Toothpaste B reduced H(2)S(cys) by 48% compared with toothpaste C (p = 0.001). It is suggested that the superior effect of the experimental toothpaste was most likely due to a higher Zn concentration combined with longer retention of Zn due to the PVM/MA copolymer.
authors: Department of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, PO Box 1109 Blindern, NO-0317 Oslo, Norway. a.y.vik@odont.uio.no
authors: A
authors: A
authors: Young
authors: G
authors: G
authors: Jonski
mesh_terms: D000328:Adult; D001944:Breath Tests / Q000379:methods*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006209:Halitosis / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D014099:Toothbrushing; D014100:Toothpastes / Q000737:chemistry*; D055549:Volatile Organic Compounds / Q000032:analysis*; D055815:Young Adult; D015032:Zinc / Q000032:analysis*
chemical_list: D014100:Toothpastes; D055549:Volatile Organic Compounds; D015032:Zinc