title: Cytotoxic ent-kaurane diterpenoids from Isodon henryi.
abstract: Five new ent-kaurane diterpenoids, isodonhenrins A-E (1-5), together with thirteen known ones were isolated from the aerial parts of Isodon henryi. Their structures were identified by means of extensive spectroscopic analysis, and the absolute configurations of 1 were determined by single-crystal X-ray diffraction. Most of the diterpenoids were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. Compound 17 showed significant inhibitory effects on five cell lines, and compounds 6, 9, 10, 11, 12 and 16 exhibited selective activity.
authors: College of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P. R. China.
authors: Zhuo
authors: Z
authors: Hu
authors: Rui
authors: R
authors: Zhan
authors: Xue
authors: X
authors: Du
authors: Jia
authors: J
authors: Su
authors: Xiao-Nian
authors: XN
authors: Li
authors: Jian-Hong
authors: JH
authors: Yang
authors: Hai-Bo
authors: HB
authors: Zhang
authors: Yan
authors: Y
authors: Li
authors: Han-Dong
authors: HD
authors: Sun
authors: Gan-Peng
authors: GP
authors: Li
authors: Jian-Xin
authors: JX
authors: Pu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane