title: Clinical implications of genetic variations in the VEGF system in relation to colorectal cancer.
abstract: Colorectal cancer (CRC) constitutes one of the most common malignancies in the world and, despite advances in diagnostics and treatments, patients still face a poor prognosis and a more individualized treatment approach appears necessary. The VEGF system and angiogenesis are involved in many aspects of tumor biology and the efficacy of chemotherapy, and some targeted therapeutics appear to be related to the function of these processes. There are many reasons why genetic variations are optimal biomarkers and in relation to the VEGF system may prove to be of clinical relevance. This review evaluates the literature on SNPs in relation to the risk of CRC and the possible prognostic and predictive value and argues for the role of these biomarkers in the future treatment of patients with CRC.
authors: Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark. torben.hansen@slb.regionsyddanmark.dk
authors: Torben Frøstrup
authors: TF
authors: Hansen
authors: Anders
authors: A
authors: Jakobsen
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D018570:Risk Assessment; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1