title: Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity.
abstract: The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.
authors: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.
authors: M N
authors: MN
authors: Nasir
authors: J
authors: J
authors: Abdullah
authors: M
authors: M
authors: Habsah
authors: R I
authors: RI
authors: Ghani
authors: G
authors: G
authors: Rammes
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology; D028041:Centella / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004594:Electrophysiology; D058786:GABA-B Receptor Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D053978:Pentacyclic Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D059227:Postsynaptic Potential Summation / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018080:Receptors, GABA-B / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D058786:GABA-B Receptor Agonists; D053978:Pentacyclic Triterpenes; D018080:Receptors, GABA-B; C017032:asiatic acid; D012601:Scopolamine; D000110:Acetylcholinesterase; D001418:Baclofen; D001640:Bicuculline