title: Dual therapy with cidofovir and mirtazapine for progressive multifocal leukoencephalopathy in a sarcoidosis patient.
abstract: BACKGROUND
  Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by JC virus (JCV) reactivation in immunocompromised patients. The disease course of PML is often progressive, fatal and at present, there are few reports on successful treatment outcomes.
  
  
  METHODS
  A 45-year-old man with systemic sarcoidosis presented with rapidly progressive dementia and right hemiparesis. The patient was diagnosed with PML as confirmed via brain biopsy and JCV PCR. With a combination treatment of cidofovir and mirtazapine, there was significant improvement of neurological symptoms without measurable functional deficit.
  
  
  CONCLUSIONS
  This case suggests that dual therapy with cidofovir and mirtazapine might be an effective treatment option in PML patients with sarcoidosis.
authors: Departments of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Jae Hyun
authors: JH
authors: Park
authors: Sookyung
authors: S
authors: Ryoo
authors: Hyun Jin
authors: HJ
authors: Noh
authors: Jung Min
authors: JM
authors: Seo
authors: Hyun Hee
authors: HH
authors: Kang
authors: Ji Soo
authors: JS
authors: Shin
authors: Sang Won
authors: SW
authors: Seo
authors: Duk L
authors: DL
authors: Na