title: Successful management of primary non Hodgkins lymphoma of the cranial vault.
abstract: Primary bone lymphoma (PBL) is a relatively uncommon entity. However, involvement of the cranial vault is an unusual manifestation of aggressive non-Hodgkin's lymphoma. We report the case of a 42-year old immunocompetent woman who presented with an enlarging mass involving the right parietal bone. Magnetic resonance imaging (MRI) of the brain revealed an expansive tumor that affects the right parietal bone. Computed tomographic (CT) scans of the abdomen, chest and pelvis were negative for lymphadenopathy or organomegaly. Biopsy of the mass showed diffuse large B-cell non-Hodgkin's lymphoma confirmed by immunohistochemical study. The patient had a complete response after 4 cycles of chemotherapy followed by external beam radiotherapy. After a follow-up of more than 9 months the patient is still in good local control without distant metastasis. The aim of our work is to report a case of Primary bone lymphoma of the cranial vault with good response to treatment combining sequential chemotherapy and radiotherapy.
authors: Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
authors: Zouhour
authors: Z
authors: Fadoukhair
authors: Issam
authors: I
authors: Lalya
authors: Mounia
authors: M
authors: Amzerin
authors: Basma
authors: B
authors: Elkhanoussi
authors: Yassir
authors: Y
authors: Sbitti
authors: Saber
authors: S
authors: Boutayeb
authors: Hind
authors: H
authors: M'rabti
authors: Noureddine
authors: N
authors: Benjaafar
authors: Hassan
authors: H
authors: Errihani
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D010294:Parietal Bone / Q000473:pathology*; D012888:Skull Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents