title: Utilization and costs of lipid modifying therapies following health technology assessment for the new reimbursement scheme in Sweden.
abstract: BACKGROUND
  A new reimbursement scheme (RS) for lipid modifying therapies (LMT) was implemented in Sweden in June 2009. Products on the market were continued, restricted or excluded in the new RS. The aim of this study was to compare utilization, costs and switching behavior in patients treated with LMT before and after the new RS.
  
  
  METHODS
  This is a quasi-experimental study using data on dispensed LMT and costs from a database on dispensed individual prescriptions in Sweden. Segmented regression analyses were used to assess utilization and costs of LMT.
  
  
  RESULTS
  Number of patients treated with products with restricted reimbursement increased in level (P=0.0336) following the changes in the scheme, while decreased in level (P<0.0001) for products excluded from the RS. Patients initially treated with products excluded from the RS discontinued to a greater extent, and switched to higher doses of the same substance or to generic simvastatin. The total annual costs decreased moderately.
  
  
  CONCLUSIONS
  The decreasing trend in utilization of low-dose atorvastatin and rosuvastatin was accelerated and so was the increasing trend in utilization of generic simvastatin following the new RS. Switching to higher doses and discontinuation increased and expected savings were overestimated.
authors: The Center for Medical Technology Assessment, CMT Linköping University, Sweden. Billie pettersson@merck.com
authors: Billie
authors: B
authors: Pettersson
authors: Mikael
authors: M
authors: Hoffmann
authors: Per
authors: P
authors: Wändell
authors: Lars-Åke
authors: LÅ
authors: Levin
mesh_terms: D017723:Drug Utilization Review; D017850:Economics, Pharmaceutical; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000191:economics*; D007349:Insurance, Health, Reimbursement / Q000191:economics*; D007356:Insurance, Pharmaceutical Services / Q000191:economics*; D016014:Linear Models; D012051:Reimbursement Mechanisms / Q000191:economics*; D013548:Sweden; D013673:Technology Assessment, Biomedical / Q000191:economics*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors