title: Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties.
abstract: New 2,4-thiazolidinediones with aryl sulfonylurea moieties have been synthesized by condensing various substituted sulfonamides and 5-(isocyanatomethyl) thiazolidino-2,4-dione. The isocyanomethyl thiazolidinedione was obtained by using the Curtius rearrangement, starting from known 2,4-dioxo-5-thiazolidineacetic acid. The newly synthesized compounds have been evaluated for the antihyperglycemic activity in normal rats model and among these compounds showed significant antihyperglycemic activity in sucrose loaded rat model.
authors: Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, Maharashtra, India.
authors: Dhanaji V
authors: DV
authors: Jawale
authors: Umesh R
authors: UR
authors: Pratap
authors: Neha
authors: N
authors: Rahuja
authors: Arvind K
authors: AK
authors: Srivastava
authors: Ramrao A
authors: RA
authors: Mane
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D003920:Diabetes Mellitus / Q000188:drug therapy*; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008956:Models, Chemical; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000737:chemistry; D013453:Sulfonylurea Compounds / Q000737:chemistry*; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D045162:Thiazolidinediones; D013395:Sucrose; C089946:2,4-thiazolidinedione