title: GM-CSF is not essential for optimal fertility or for weight control.
abstract: Independent studies with GM-CSF-/- mice have concluded that GM-CSF is necessary for normal reproductive outcome and for the maintenance of normal weight. In contrast to the literature we report that GM-CSF-/- and wild type (C57Bl/6) mice over a continuous 12 month period had similar litter size and neonatal survival. Likewise, unlike a literature observation, for the two mouse strains both male and female mice had similar weight gain when fed on a normal chow diet and monitored until 30 weeks of age. It is concluded that GM-CSF is not necessary for an optimal fertility outcome or for normal weight maintenance during development.
authors: Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Victoria 3050, Australia. jahami@unimelb.edu.au
authors: John A
authors: JA
authors: Hamilton
authors: Jennifer
authors: J
authors: Davis
authors: Jarrad
authors: J
authors: Pobjoy
authors: Andrew D
authors: AD
authors: Cook
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000502:physiology*; D005260:Female; D005298:Fertility / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000172:deficiency / Q000378:metabolism*; D008098:Litter Size / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D016019:Survival Analysis
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor