title: B cells and autoimmunity.
abstract: There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed.
authors: Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States. pillai@helix.mgh.harvard.edu
authors: Shiv
authors: S
authors: Pillai
authors: Hamid
authors: H
authors: Mattoo
authors: Annaiah
authors: A
authors: Cariappa
mesh_terms: D000818:Animals; D015551:Autoimmunity; D053264:B-Cell Activating Factor / Q000037:antagonists & inhibitors / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D015398:Signal Transduction
chemical_list: D053264:B-Cell Activating Factor