title: Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L.
abstract: One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (nirtetralin A), 16.7 µM (nirtetralin B) and 97.2 µM (nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (nirtetralin A), 69.3 µM (nirtetralin B) and 232.0 µM (nirtetralin), respectively.
authors: Department of Chemistry, Guangxi University, Nanning 530004, People's Republic of China. chewxwei@yahoo.com.cn
authors: Wanxing
authors: W
authors: Wei
authors: Xiangrong
authors: X
authors: Li
authors: Kuiwu
authors: K
authors: Wang
authors: Zuowen
authors: Z
authors: Zheng
authors: Min
authors: M
authors: Zhou
mesh_terms: D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000840:Anisoles; D000998:Antiviral Agents; D004149:Dioxoles; D017705:Lignans; D010936:Plant Extracts; C475933:nirtetralin