title: [Anticancer drugs management in renal insufficiency patients].
abstract: Anticancer drug management is complicated especially in renal insufficiency patients, a frequent situation in oncology. Several aspects need to be taken into account: first, the dosage. In this population, the kidney fails to eliminate drugs. Consequently, dosage adjustment can be necessary for drugs with pharmacokinetic profile altered by renal insufficiency in order to avoid dose-related side effects due to accumulation of the drug. Secondly, renal tolerance is an important aspect of anticancer drug management as renal insufficiency is a risk factor for developing renal side effects. Prevention of renal side effects is essential and means to limit this toxicity should be used, especially with hydration. Finally, it is essential to consider all the treatments prescribed in renal insufficiency patients in order to avoid accumulation of nephrotoxic drugs.
authors: Hôpital de la Pitié-Salpêtrière, service ICAR, Paris, France.
authors: Sarah
authors: S
authors: Zimmer-Rapuch
authors: Stéphanie
authors: S
authors: Lheureux
authors: Fabien
authors: F
authors: Brocard
authors: Nicolas
authors: N
authors: Janus
authors: Vincent
authors: V
authors: Launay-Vacher
authors: Isabelle
authors: I
authors: Ray-Coquard
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005440:Fluid Therapy; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy; D051437:Renal Insufficiency / Q000378:metabolism* / Q000628:therapy; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents