title: The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin.
abstract: BACKGROUND
  Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS.
  
  
  METHODS
  We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9±10.8 y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS.
  
  
  RESULTS
  K-IDF criteria-based MetS occurred in 37.0% (n=1146) of patients. IGF-1 (91.5 vs. 97.3 ng/ml, p<0.001) and adiponectin (3.95 vs. 4.23 μg/ml, p<0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend<0.001, F=12.615, p<0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7%, n=206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95% CI 0.493-0.977, p=0.036).
  
  
  CONCLUSIONS
  IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.
authors: Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Jaewon
authors: J
authors: Oh
authors: Jong-Youn
authors: JY
authors: Kim
authors: Sungha
authors: S
authors: Park
authors: Jong-Chan
authors: JC
authors: Youn
authors: Nak Hoon
authors: NH
authors: Son
authors: Dong-Jik
authors: DJ
authors: Shin
authors: Sang-Hak
authors: SH
authors: Lee
authors: Seok-Min
authors: SM
authors: Kang
authors: Sun Ha
authors: SH
authors: Jee
authors: Yangsoo
authors: Y
authors: Jang
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000368:Aged; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D052242:Adiponectin; D007334:Insulin-Like Growth Factor I