title: Indole alkaloids from Ervatamia chinensis.
abstract: Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors: Ling-Li
authors: LL
authors: Guo
authors: Hong-Ping
authors: HP
authors: He
authors: Ying-Tong
authors: YT
authors: Di
authors: Shi-Fei
authors: SF
authors: Li
authors: Yuan-Yuan
authors: YY
authors: Cheng
authors: Wei
authors: W
authors: Yang
authors: Yan
authors: Y
authors: Li
authors: Jian-Ping
authors: JP
authors: Yu
authors: Yu
authors: Y
authors: Zhang
authors: Xiao-Jiang
authors: XJ
authors: Hao
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles; D010936:Plant Extracts; D002945:Cisplatin