title: Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro.
abstract: Anthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vulgaris. Besides that, it exhibited a high inhibitory effect on the LPS-induced nitrite production and a strong cytotoxic activity, especially against amelanotic melanoma (C32) and large lung cell carcinoma (COR-L23) cell lines.
authors: Department of Pharmaceutical Sciences, University of Calabria, Via Pietro Bucci, I-87036 Rende, Italy.
authors: Filomena
authors: F
authors: Conforti
authors: Federica
authors: F
authors: Menichini
authors: Carmen
authors: C
authors: Formisano
authors: Daniela
authors: D
authors: Rigano
authors: Felice
authors: F
authors: Senatore
authors: Maurizio
authors: M
authors: Bruno
authors: Sergio
authors: S
authors: Rosselli
authors: Sezgin
authors: S
authors: Celik
mesh_terms: D000818:Animals; D031166:Anthemis / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry; D009573:Nitrites / Q000378:metabolism*; D009822:Oils, Volatile / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D008070:Lipopolysaccharides; D039821:Monoterpenes; D009573:Nitrites; D009822:Oils, Volatile