title: Kinetics of physiological skin flora in a suction blister wound model on healthy subjects after treatment with water-filtered infrared-A radiation.
abstract: The effect of water-filtered infrared-A radiation (wIRA) on normal skin flora was investigated by generating experimental wounds on the forearms of volunteers utilizing the suction blister technique. Over 7 days, recolonization was monitored parallel to wound healing. Four groups of treatment were compared: no therapy (A), dexpanthenol cream once daily (B), 20 min wIRA irradiation at 30 cm distance (C), and wIRA irradiation for 30 min once daily together with dexpanthenol cream once daily (D). All treatments strongly inhibited the recolonization of the wounds. Whereas dexpanthenol completely suppressed recolonization over the test period, recolonization after wIRA without (C) and in combination with dexpanthenol (D) was suppressed, but started on day 5 with considerably higher amounts after the combination treatment (D). Whereas the consequence without treatment (A) was an increasing amount of physiological skin flora including coagulase-negative staphylococci, all treatments (B-D) led to a reduction in physiological skin flora, including coagulase-negative staphylococci. In healthy volunteers, wIRA alone and in combination with dexpanthenol strongly inhibited bacterial recolonization with physiological skin flora after artificial wound setting using a suction-blister wound model. This could support the beneficial effects of wIRA in the promotion of wound healing.
authors: Department of Dermatology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany. georg.daeschlein @ uni-greifswald.de
authors: G
authors: G
authors: Daeschlein
authors: J
authors: J
authors: Alborova
authors: A
authors: A
authors: Patzelt
authors: A
authors: A
authors: Kramer
authors: J
authors: J
authors: Lademann
mesh_terms: D000328:Adult; D001768:Blister / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D005260:Female; D005374:Filtration; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011446:Prospective Studies; D012867:Skin / Q000382:microbiology / Q000473:pathology / Q000528:radiation effects*; D013396:Suction; D016896:Treatment Outcome; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects*; D055815:Young Adult
chemical_list: D014867:Water; D010205:Pantothenic Acid; C007288:dexpanthenol