title: Changes in the myocardial interstitium and contribution to the progression of heart failure.
abstract: The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium.
authors: Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, 114 Doughty Street, Suite 326, Charleston, SC 29425, USA.
authors: Shaina R
authors: SR
authors: Eckhouse
authors: Francis G
authors: FG
authors: Spinale
mesh_terms: D000818:Animals; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism* / Q000648:ultrastructure; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D020257:Ventricular Remodeling