title: Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs.
abstract: Development of glioma-specific nanoparticles has been an area of intense research over the past several years. Iron oxide, multifunctional superparamagnetic, and NaYF(4):Yb,rare-earth upconversion nanoparticles, conjugated with chlorotoxin (CTX, a key toxin in scorpion venom which has been shown to bind specifically to glioma cell surface as a specific chloride channel and matrix metalloproteinase-2 blocker), exhibit high affinity for glioma and direct tumor visualization. We review the latest improvements of CTX-modified nanoparticle platforms which might enable development of more effective therapeutic agents in clinical treatment of glioma.
authors: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, People's Republic of China. yjfu@sxu.edu.cn
authors: Yuejun
authors: Y
authors: Fu
authors: Na
authors: N
authors: An
authors: Ke
authors: K
authors: Li
authors: Yali
authors: Y
authors: Zheng
authors: Aihua
authors: A
authors: Liang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D012604:Scorpion Venoms / Q000627:therapeutic use*
chemical_list: D012604:Scorpion Venoms; C091539:Chlorotoxin