title: Synthesis of methacrylate monomers with antibacterial effects against S. mutans.
abstract: A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
authors: Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland. hejin@utu.fi
authors: Jingwei
authors: J
authors: He
authors: Eva
authors: E
authors: Söderling
authors: Monica
authors: M
authors: Österblad
authors: Pekka K
authors: PK
authors: Vallittu
authors: Lippo V J
authors: LV
authors: Lassila
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003764:Dental Materials; D006801:Humans; D008689:Methacrylates / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003764:Dental Materials; D008689:Methacrylates; D000644:Quaternary Ammonium Compounds