title: Ripoptosome: a novel IAP-regulated cell death-signalling platform.
abstract: Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serine-threonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ~2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.
authors: Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
authors: Gergely
authors: G
authors: Imre
authors: Sarit
authors: S
authors: Larisch
authors: Krishnaraj
authors: K
authors: Rajalingam
mesh_terms: D016923:Cell Death; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053422:Receptor-Interacting Protein Serine-Threonine Kinases