title: Myo-inositol may prevent gestational diabetes in PCOS women.
abstract: To evaluate retrospectively the prevalence of gestational diabetes (GD) in pregnancies obtained with myo-inositol administration in women with polycystic ovary syndrome. A total of 98 pregnancies in PCOS women obtained in a 3-year period, either with myo-inositol (n. 54), or with metformin (n. 44) were considered. While myo-inositol was assumed through the whole pregnancy, the group of women treated with metformin stopped the drug assumption after pregnancy diagnosis, and was considered as a control group. After having eliminated cases of miscarriages and twin pregnancies, a definitive number of 46 women in the myo-inositol group and 37 in the control group was taken in account to be retrospectively evaluated. The primary outcome measure was GD occurrence in both groups; whereas secondary outcome measures were pregnancy outcomes: hypertensive disorders, pre-term birth, macrosomia and caesarean section occurrence. Prevalence of GD in the myo-inositol group was 17.4% versus 54% in the control group, with a highly significant difference also after adjusting for covariates. Consequently, in the control group the risk of GD occurrence was more than double compared to the myo-inositol group, with an odds ratio 2.4 (confidence interval 95%, 1.3-4.4). There was no difference between the groups in relation to secondary outcome measures. This study suggests a possible effect of myo-inositol in the primary prevention of GD in PCOS women.
authors: Department of Obstetrics and Gynecology, University of Messina, Italy. rosariodanna@tin.it
authors: R
authors: R
authors: D'Anna
authors: V
authors: V
authors: Di Benedetto
authors: P
authors: P
authors: Rizzo
authors: E
authors: E
authors: Raffone
authors: M L
authors: ML
authors: Interdonato
authors: F
authors: F
authors: Corrado
authors: A
authors: A
authors: Di Benedetto
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007294:Inositol / Q000494:pharmacology / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology; D015995:Prevalence; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D007004:Hypoglycemic Agents; D007294:Inositol; D008687:Metformin