title: Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax.
abstract: We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
authors: Departamento de Biociências, Campus Universitário Prof. Alberto Carvalho, Universidade Federal de Sergipe, Itabaiana, SE, Brazil. stortilu@yahoo.com.br
authors: Luciane Moreno
authors: LM
authors: Storti-Melo
authors: Daniela Reis
authors: DR
authors: da Costa
authors: Wanessa Christina
authors: WC
authors: Souza-Neiras
authors: Gustavo Capatti
authors: GC
authors: Cassiano
authors: Vanja Suely Calvosa D'Almeida
authors: VS
authors: Couto
authors: Marinete Marins
authors: MM
authors: Póvoa
authors: Irene da Silva
authors: Ida S
authors: Soares
authors: Luzia Helena
authors: LH
authors: de Carvalho
authors: Myrian
authors: M
authors: Arevalo-Herrera
authors: Sócrates
authors: S
authors: Herrera
authors: Andrea Regina Baptista
authors: AR
authors: Rossit
authors: José Antonio
authors: JA
authors: Cordeiro
authors: Luiz Carlos
authors: LC
authors: de Mattos
authors: Ricardo Luiz Dantas
authors: RL
authors: Machado
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D001938:Brazil; D004797:Enzyme-Linked Immunosorbent Assay; D005787:Gene Frequency; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016780:Malaria, Vivax / Q000276:immunology*; D008875:Middle Aged; D010966:Plasmodium vivax / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D059811:HLA-DRB1 Chains; D007074:Immunoglobulin G