title: Morphological properties of nanoporous folic acid materials and in vitro assessment of their biocompatibility.
abstract: BACKGROUND
  Mesoporous silica-based particles are of potential interest for the development of novel therapeutic targeted delivery vehicles. Their ability to load and release large quantities of active pharmaceutical products with varying properties, combining controlled and targeted release functions make them unique amongst nanotechnology-based carrier systems.
  
  
  METHODS
  In this study, nanoporous folic acid-templated materials (NFM-1) were prepared and the synthetic strategies for the control of textural and morphology properties of NFM-1 are described. The potential biocompatibility of NFM-1 particles with different morphology (gyroid shaped, fibers and rod-shaped) was assessed using a panel of human cell lines.
  
  
  RESULTS
  The results reveal that NFM-1 morphology has an impact on cell viability such that particles showing higher aspect ratios possess increased cytotoxicity.
  
  
  CONCLUSIONS
  These studies provide useful information for the development of novel mesoporous materials for biomedical applications, including cell-specific drug delivery.
authors: Nanologica AB, Drottning Kristinas Väg 45, SE-114 28 Stockholm, Sweden.
authors: Chunfang
authors: C
authors: Zhou
authors: Andrea
authors: A
authors: Kunzmann
authors: Marija
authors: M
authors: Rakonjac
authors: Bengt
authors: B
authors: Fadeel
authors: Alfonso
authors: A
authors: Garcia-Bennett
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D016062:Porosity
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005492:Folic Acid