title: microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma.
abstract: microRNAs (miRs) are a recently recognized class of noncoding short RNAs, 17-25 nucleotides in length, that play a role in post-transcriptional gene regulation by translational repression and/or mRNA degradation. Various miRs have been highlighted in pancreatic cancer development and metastasis, and as potential clinical diagnostic/prognostic biomarkers. Recently, studies have indicated that miRs are responsible for resistance to chemotherapeutic agents. The miR-10b has been identified as a 'metastamiR' in various tumor types, notably breast cancer, but data surrounding its relevance in pancreatic ductal adenocarcinoma has been sparse. The evaluated article presents data indicating that miR-10b is upregulated in pancreatic ductal adenocarcinoma and can be used as a diagnostic marker in endoscopic ultrasound-guided fine-needle aspiration biopsies of suspicious pancreatic lesions. In addition, miR-10b may be able to guide neoadjuvant gemcitabine-based chemoradiotherapy and predict metastatic-free survival and overall survival.
authors: HPB Surgical Unit, Department of Surgery & Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK. a.frampton@imperial.ac.uk
authors: Adam E
authors: AE
authors: Frampton
authors: Jonathan
authors: J
authors: Krell
authors: Jimmy
authors: J
authors: Jacob
authors: Justin
authors: J
authors: Stebbing
authors: Long R
authors: LR
authors: Jiao
authors: Leandro
authors: L
authors: Castellano