title: Atrial selective effect of amiodarone to increase threshold of excitation.
abstract: Increases of pacing threshold stimulation are well documented with different antiarrhythmic drugs, but not with amiodarone. We report a case of a patient with dual-chamber pacing, with stable thresholds on repeated measurements on the last year, who presented severe increase of atrial pacing threshold resulting in loss of atrial capture after a year of treatment with amiodarone. Thresholds were normalized once amiodarone was removed. Ventricular thresholds were not affected.
authors: Department of Cardiology, Severo Ochoa Hospital, Madrid, Spain. jmgrande196@gmail.com
authors: Juan Manuel
authors: JM
authors: Grande
authors: Angel
authors: A
authors: Grande
authors: Maria
authors: M
authors: Molina
authors: Carolina
authors: C
authors: Novo
authors: Fernando
authors: F
authors: Cabestrero
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D055724:Electrophysiological Phenomena; D006325:Heart Atria / Q000187:drug effects* / Q000503:physiopathology*; D006801:Humans; D010138:Pacemaker, Artificial
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone