title: A crude extract from immature green tea (Camellia sinensis) leaves promotes Toll-like receptor 7-mediated interferon-α production in human macrophage-like cells.
abstract: Toll-like receptor 7 (TLR7) senses viral single-stranded RNA (ssRNA), induces the production of type I interferons (IFNs), IFN-α and -β, in macrophages such as dendritic cells (DCs), and its immune system protects the host from virus infection. Here, we found that a crude extract from immature green tea leaves (iTPS) containing a macromolecule with ssRNA fragments, induces IFN-α production in human macrophage-like cells. In addition IFN-α production was inhibited by treatment with TLR7 inhibitors or a phagocytosis inhibitor.
authors: NARO Institute of Vegetable and Tea Science (NIVTS), 2769 Kanaya-Shishidoi, Shimada, Shizuoka, 428-8501, Japan, monobe@affrc.go.jp.
authors: Manami
authors: M
authors: Monobe
authors: Akiko
authors: A
authors: Ogino
authors: Kaori
authors: K
authors: Ema
authors: Yoshiko
authors: Y
authors: Tokuda
authors: Mari
authors: M
authors: Maeda-Yamamoto