title: Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs.
abstract: Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABA-dependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCAR-ABA-PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response.
authors: Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Valencia. Avd de los Naranjos, Edificio CPI 8E, ES-46022 Valencia, Spain.
authors: Julia
authors: J
authors: Santiago
authors: Florine
authors: F
authors: Dupeux
authors: Katja
authors: K
authors: Betz
authors: Regina
authors: R
authors: Antoni
authors: Miguel
authors: M
authors: Gonzalez-Guzman
authors: Lesia
authors: L
authors: Rodriguez
authors: José Antonio
authors: JA
authors: Márquez
authors: Pedro L
authors: PL
authors: Rodriguez
mesh_terms: D000040:Abscisic Acid / Q000737:chemistry / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000737:chemistry / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism*; D000071636:Protein Phosphatase 2C; D013312:Stress, Physiological; D013329:Structure-Activity Relationship
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D010937:Plant Growth Regulators; D010940:Plant Proteins; D000040:Abscisic Acid; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C