title: Cyclic ether-containing macrolactins, antimicrobial 24-membered isomeric macrolactones from a marine Bacillus sp.
abstract: Bioassay-guided isolation of bioactive metabolites from the ethyl acetate extract of a marine Bacillus sp. fermentation broth has led to the discovery of three new 24-membered macrolactones, macrolactins 1-3, which contain an oxetane, an epoxide, and a tetrahydropyran ring, respectively. The configurations of 1-3 were assigned by a combination of coupling constants, ROESY data analysis, and application of the modified Mosher's method. Compounds 1-3 showed in vitro antimicrobial activity.
authors: Marine Natural Products Chemistry Laboratory,  Korea Ocean Research & Development Institute , Ansan, P.O. Box 29, Seoul 425-600, Republic of Korea.
authors: M A Mojid
authors: MA
authors: Mondol
authors: Fakir Shahidullah
authors: FS
authors: Tareq
authors: Ji Hye
authors: JH
authors: Kim
authors: Min ah
authors: Ma
authors: Lee
authors: Hyi-Seung
authors: HS
authors: Lee
authors: Yeon-Ju
authors: YJ
authors: Lee
authors: Jong Seok
authors: JS
authors: Lee
authors: Hee Jae
authors: HJ
authors: Shin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D004988:Ethers, Cyclic; C570423:macrolactin 1; C570425:macrolactin 2; C570424:macrolactin 3