title: Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents.
abstract: Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 µM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.
authors: Department of Chemistry, Yonsei University, Seoul, Korea.
authors: Jérémy
authors: J
authors: Ricci
authors: Minkyu
authors: M
authors: Kim
authors: Won-Yoon
authors: WY
authors: Chung
authors: Kwang-Kyun
authors: KK
authors: Park
authors: Mankil
authors: M
authors: Jung
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006017:Glycolipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; D006017:Glycolipids; C063801:deoxoartemisinin