title: Bordetella pertussis IgG and IgA antibodies seroprevalence among 1-35 y-old population: the role of subclinical pertussis infection.
abstract: OBJECTIVE
  To determine age-dependent pertussis specific IgG and IgA antibodies seroprevalence in apparently healthy subjects.
  
  
  METHODS
  A total of 595 healthy 1-35-y-old individuals divided into 5 different age groups were selected from Sari district. Antipertussis IgG and IgA antibodies levels were measured quantitatively by ELISA method. Positive sera for IgA and also IgG titer ≥150 were considered for recent pertussis infection.
  
  
  RESULTS
  High seroprevelence levels (72% and 71%) were observed among preschool (<7 y) children. After decreasing the seroprevelence rates significally to lowest level (54.4%) among school aged (7-11 y), the rates increased again to the highest levels of 60% and 73% at adulthood (P = 0.03 and P = 0.003). In total, 1.55% of study subjects were IgA positive, and 5.7% showed high IgG titers.
  
  
  CONCLUSIONS
  The present study reveals, vaccine induced immunity has decreased among school-aged children and natural pertussis infection is common among adolescent and young adults. Also, asymptomatic/sub-clinical recent pertussis infection was prevalent among studied population. These findings necessitate developing new strategies to reduce and control pertussis infection in Iran.
authors: Department of Pediatric infectious diseases, Bouali-Cina Hospital, Pasdaran Boulevard, Mazandaran University of Medical Sciences, Sari, Iran. saffar@softhome.net
authors: Mohammed-Jafar
authors: MJ
authors: Saffar
authors: Ali-Reza
authors: AR
authors: Khalilian
authors: Ali-Reza
authors: AR
authors: Rafee
authors: Mohammed Reza
authors: MR
authors: Parsaei
authors: Shadi
authors: S
authors: Imanikhani
authors: Jalil
authors: J
authors: Shojaei
authors: Hana
authors: H
authors: Saffar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D058345:Asymptomatic Infections; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007492:Iran / Q000453:epidemiology; D008297:Male; D010567:Pertussis Vaccine / Q000276:immunology*; D016036:Seroepidemiologic Studies; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010567:Pertussis Vaccine