title: Development and evaluation of mucoadhesive buccal patches of flurbiprofen.
abstract: In the present study, an attempt was made to formulate mucoadhesive buccal patches of flurbiprofen (FBN) in order to enhance solubility. Solubity enhancement was attempted by making solid dispersion of drug with beta-CD (cyclodextrin). Initially preformulation were carried out using reported methods. Buccal patches were prepared by solvent casting technique using polymers like polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (SCMC), and hydroxypropyl methylcellulose (HPMC). The prepared patches were evaluated for their weight variation, thickness, folding endurance, surface pH, swelling index, in vitro residence time, in vitro permeation studies, drug content uniformity and bioadhesion test.
authors: School of Pharmaceutical Sciences, Shobhit University, Meerut, India. mishra_santosh24@yahoo.co.in
authors: Santosh Kumar
authors: SK
authors: Mishra
authors: Navneet
authors: N
authors: Garud
authors: Ranjit
authors: R
authors: Singh
mesh_terms: D000268:Adhesiveness; D000278:Administration, Buccal; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D005480:Flurbiprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D009093:Mucus / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D004304:Dosage Forms; D004337:Drug Carriers; D011108:Polymers; D047392:beta-Cyclodextrins; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; D005480:Flurbiprofen; D011142:Polyvinyl Alcohol; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium