title: The influence of obesity on progression of coronary arteriosclerosis and clinical course after ST elevation acute myocardial infarction treated with primary coronary interventions.
abstract: OBJECTIVE
  Evaluation of influence of obesity on the coronary atherosclerosis development and clinical outcome in patients with STEMI treated by PCI with BMS implantation.
  
  
  METHODS
  82 patients (64 men) treated with PCI within 6 hours from 1st STEMI. Three groups of pts were formed according to BMI. Based on coronary angiography number of significant stenoses (NSS), number of stenosed coronary arteries (NSA), and sum of significant stenoses (SSS) were calculated. Echocardiography examination was performed 3 days and 6 months after STEMI. Serial evaluation of TnI, CK, CKMB was performed after admission, and serum BNP was assessed after 2 days, 1 and 6 months after STEMI.
  
  
  RESULTS
  Obese patients revealed higher values of NSA, NSS and SSS than patients with normal BMI and overweight. There were no differences of BNP, maximal values and AUC of CK, CKMB, TnI and echocardiographic parameters between all groups whereas decrease of BNP during follow-up correlated with BMI.
  
  
  CONCLUSIONS
  Results of our prospective study indicate that in obese patients, there is a significantly greater number of atherosclerotic lesions in coronary arteries found during PCI, as compared to those with normal body weight or overweight. We proved that overweight and obesity did not result in significantly greater damage to the myocardium and left ventricular dysfunction, both in the acute phase and 6 months after myocardial infarction treated with primary coronary intervention, as compared to those with normal body weight. In addition correlation was found between BNP concentration profile and body mass index in the 6-month follow-up after STEMI treated with PCI and bare metal stent implantation.
authors: Coronary Disease Department, Institute of Cardiology, Medical School of Jagiellonian University, John Paul II Hospital, Cracow, Poland. apietrucha@wp.pl
authors: A Z
authors: AZ
authors: Pietrucha
authors: P J
authors: PJ
authors: Stryjewski
authors: N
authors: N
authors: El-Massri
authors: G
authors: G
authors: Gajos
authors: O
authors: O
authors: Kruszelnicka
authors: L
authors: L
authors: Badacz
authors: W
authors: W
authors: Piwowarska
authors: J
authors: J
authors: Nessler
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D019540:Area Under Curve; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals / Q000737:chemistry; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology* / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D009765:Obesity / Q000150:complications / Q000628:therapy*; D011446:Prospective Studies; D015607:Stents; D018487:Ventricular Dysfunction, Left / Q000473:pathology
chemical_list: D008670:Metals