title: Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis.
abstract: BACKGROUND
  Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions.
  
  
  OBJECTIVE
  To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls.
  
  
  METHODS
  Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach.
  
  
  RESULTS
  Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar.
  
  
  CONCLUSIONS
  In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.
authors: Unidad de Medicina y Cirugía Experimental, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón and Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain. jjanssen@mce.hggm.es
authors: Joost
authors: J
authors: Janssen
authors: Yasser
authors: Y
authors: Alemán-Gómez
authors: Santiago
authors: S
authors: Reig
authors: Hugo G
authors: HG
authors: Schnack
authors: Mara
authors: M
authors: Parellada
authors: Montserrat
authors: M
authors: Graell
authors: Carmen
authors: C
authors: Moreno
authors: Dolores
authors: D
authors: Moreno
authors: J M
authors: JM
authors: Mateos-Pérez
authors: J M
authors: JM
authors: Udias
authors: Celso
authors: C
authors: Arango
authors: Manuel
authors: M
authors: Desco
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D020643:Anterior Thalamic Nuclei / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009929:Organ Size; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology / Q000473:pathology*; D020649:Pulvinar / Q000473:pathology; D012559:Schizophrenia / Q000453:epidemiology / Q000473:pathology*; D013788:Thalamus / Q000473:pathology*; D055815:Young Adult