title: NLRP1, a regulator of innate immunity associated with vitiligo.
abstract: Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation and apoptosis. How polymorphic variants of the NLRP1 gene contribute to the pathogenesis of vitiligo remains mysterious, requiring further investigation.
authors: Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.
authors: Andrea
authors: A
authors: D'Osualdo
authors: John C
authors: JC
authors: Reed
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D051379:Mice; D005810:Multigene Family; D000070576:NLR Proteins; D011110:Polymorphism, Genetic; D014820:Vitiligo / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D000070576:NLR Proteins; C427903:NLRP1 protein, human; D020169:Caspases