title: Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation.
abstract: Historically, the development of type 2 diabetes has been considered not to have an autoimmune component, in contrast to the autoimmune pathogenesis of type 1 diabetes. In this review we will discuss the accumulating data supporting the concept that islet autoreactivity and inflammation is present in type 2 diabetes pathogenesis, and the islet autoimmunity appears to be one of the factors associated with the progressive nature of the type 2 diabetes disease process.
authors: Department of Medicine, University of Washington, Seattle, WA, USA. bbrooks@u.washington.edu
authors: B
authors: B
authors: Brooks-Worrell
authors: J P
authors: JP
authors: Palmer
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000276:immunology / Q000473:pathology; D007515:Islets of Langerhans / Q000276:immunology*; D018448:Models, Immunological; D009765:Obesity / Q000209:etiology / Q000276:immunology; D051381:Rats; D017634:Self Tolerance / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D018836:Inflammation Mediators