title: Coumarins from Daphne feddei and their potential anti-inflammatory activities.
abstract: Chemical examination of the methanolic extract from the stem bark of Daphne feddei led to the isolation of three new dicoumarin glucosides (1-3), and eight known coumarins, dicoumarins and dicoumarin glucosides. Their structures were elucidated by extensive analysis of spectral data and comparison with the literature values. All compounds were tested for inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 macrophages, and compounds 4 and 5 showed potent inhibitory activity with IC₅₀ values of 0.161 and 0.127 μM, respectively.
authors: School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.
authors: Shuang
authors: S
authors: Liang
authors: Yi
authors: Y
authors: Feng
authors: Jun-Mian
authors: JM
authors: Tian
authors: Min
authors: M
authors: Lu
authors: Zhi
authors: Z
authors: Xiong
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032364:Daphne / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D008070:Lipopolysaccharides; C569352:bicoumol-7'-O-beta-glucopyranoside; C569353:bicoumol-7-O-beta-glucopyranoside; D009569:Nitric Oxide