title: Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han.
abstract: OBJECTIVE
  Ankylosing spondylitis (AS) is an inflammatory disease of unknown origin. Both genetic and environmental factors are involved. A recent genome-wide association study (GWAS) found anthrax toxin receptor 2 (ANTXR2) to be associated with AS in Caucasians. We aimed to investigate whether the ANTXR2 polymorphism is also associated with AS in a Chinese Shandong Han population.
  
  
  METHODS
  From 2008 to 2009, we recruited 309 patients with AS and 384 age- and sex-matched controls of Han nationality. We selected six single nucleotide polymorphisms (SNPs) of ANTXR2 (rs4333130, rs6534708, rs6818557, rs12646132, rs12509658, and rs13140055) and genotyped them by polymerase chain reaction restriction fragment-length polymorphism (PCR-RFLP) and Taqman methods. We analysed linkage disequilibrium and constructed haplotypes.
  
  
  RESULTS
  Cases and controls did not differ in the frequency of ANTXR2 alleles, genotypes, or haplotypes. Thus, the six SNPs of ANTXR2 are not associated with AS in our Chinese Shandong Han population.
  
  
  CONCLUSIONS
  ANTXR2 might not be a susceptibility gene of AS in Chinese Han.
authors: Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, PR China.
authors: C
authors: C
authors: Guo
authors: Y
authors: Y
authors: Xia
authors: Q
authors: Q
authors: Yang
authors: R
authors: R
authors: Qiu
authors: H
authors: H
authors: Zhao
authors: Q
authors: Q
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology*; D016022:Case-Control Studies; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018000:Receptors, Peptide; D013167:Spondylitis, Ankylosing / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: C447150:ANTXR2 protein, human; D017931:DNA Primers; D008565:Membrane Proteins; D018000:Receptors, Peptide