title: Fibromyalgia and chronic fatigue syndrome in children.
abstract: BACKGROUND
  Fibromyalgia (FM) is characterized by widespread persistent pain and the presence of multiple discrete tender points. Chronic fatigue syndrome (CFS) is a syndrome characterized by debilitating fatigue associated with a variable number of non-specific complaints. Because neither condition had necessarily been recognized in children until recently, those patients have been treated as having school refusal without being diagnosed as having either syndrome. There is a considerable overlap of clinical symptoms between these two syndromes. It is therefore controversial as to whether these syndromes have the same pathogenesis or not. The aim of the present study was to clarify the relationship between these syndromes in children.
  
  
  METHODS
  Fifteen patients with FM and 21 patients with CFS were investigated both clinically and immunologically. Immunological assessments included thorough analysis of autoantibodies using several techniques.
  
  
  RESULTS
  Anti-nuclear antibody titers were higher and the prevalence of anti-Sa antibody was far more frequent in CFS patients than in FM patients.
  
  
  CONCLUSIONS
  CFS and FM are different from each other at least in childhood, from an immunological aspect, although some patients could have both conditions.
authors: Department of Pediatrics, Nippon Medical School, Sendagi, Bukyo City, Tokyo, Japan. yasuhiko@nms.ac.jp
authors: Yasuhiko
authors: Y
authors: Itoh
authors: Tomoko
authors: T
authors: Shigemori
authors: Tohru
authors: T
authors: Igarashi
authors: Yoshitaka
authors: Y
authors: Fukunaga
mesh_terms: D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000032:analysis; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D047468:Immunoprecipitation; D008297:Male
chemical_list: D000974:Antibodies, Antinuclear