title: Ruthenium-catalyzed enantioselective hydrogenation of aryl-pyridyl ketones.
abstract: Various substituted aryl-pyridyl ketones were hydrogenated in the presence of Ru-XylSunPhos-Daipen bifunctional catalytic system with enantiomeric excesses up to 99.5%. Upon introduction of a readily removable ortho-bromo atom to the phenyl ring, enantiomerically enriched 4-chlorophenylpyridylmethanol was obtained by hydrogenation method with 97.3% ee, which provided an important chiral intermediate for some histamine H(1) antagonists.
authors: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors: Xiaoming
authors: X
authors: Tao
authors: Wanfang
authors: W
authors: Li
authors: Xin
authors: X
authors: Ma
authors: Xiaoming
authors: X
authors: Li
authors: Weizheng
authors: W
authors: Fan
authors: Xiaomin
authors: X
authors: Xie
authors: Tahar
authors: T
authors: Ayad
authors: Virginie
authors: V
authors: Ratovelomanana-Vidal
authors: Zhaoguo
authors: Z
authors: Zhang