title: Dual-functional probes towards in vivo studies of brain connectivity and plasticity.
abstract: A Gd(3+) based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.
authors: Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr. 38, 72076, Tübingen, Germany. ilgar.mamedov@tuebingen.mpg.de
authors: Ilgar
authors: I
authors: Mamedov
authors: Jörn
authors: J
authors: Engelmann
authors: Oxana
authors: O
authors: Eschenko
authors: Michael
authors: M
authors: Beyerlein
authors: Nikos K
authors: NK
authors: Logothetis
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000737:chemistry* / Q000493:pharmacokinetics; D003911:Dextrans / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D008856:Microscopy, Fluorescence; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D003911:Dextrans; D005682:Gadolinium