title: Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses.
abstract: Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids over the past two decades. Many previous studies have demonstrated that synthetic delivery vehicles can be highly functionalized by chemical approaches to overcome biological barriers in nucleic acid delivery, similar to viruses. Based on our current knowledge, this tutorial review describes rational strategies in the design of polymeric materials to achieve construction of the versatile vehicles, that is "artificial viruses", for successful gene therapy, especially focusing on the chemical structures with the minimal adverse effects.
authors: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors: Kanjiro
authors: K
authors: Miyata
authors: Nobuhiro
authors: N
authors: Nishiyama
authors: Kazunori
authors: K
authors: Kataoka
mesh_terms: D016503:Drug Delivery Systems; D015195:Drug Design; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D014780:Viruses / Q000235:genetics*