title: The union of anti-CD34 antibody can improve the performance of drug-eluting stents.
abstract: OBJECTIVE
  The authors investigate whether the combination of anti-CD34 antibody with DES is win-win cooperation.
  
  
  BACKGROUND
  DES may reduce the risk of restenosis compared to bare-metal stents (BMS), but they were found to inhibit the healing process of intima.
  
  
  METHODS
  Fifteen BMS, 17 DES, and 16 combined anti-CD34 antibody and DES were randomly implanted in the coronary arteries of 22 minipigs. Ten minipigs were followed up to 2 weeks. The stenting coronary segments were examined by histological examination and scanning electron microscopy after in vivo coronary angiography and intracoronary optical coherence tomography (OCT) examinations. The other 12 minipigs were followed up to 3 months. Coronary angiography and intracoronary OCT examination were performed in vivo and histological examination was performed on the stenting coronary segments.
  
  
  RESULTS
  After 2 weeks, the neointimal covering level of the DES was lower than that in BMS, but the covering level of the combined stents was even better than the BMS. After 3 months, neointimal hyperplasia was significant in the BMS, but not in the other two types of stents. The in-stent late lumen loss of the combined stents even showed a decreasing tendency when compared with the DES.
  
  
  CONCLUSIONS
  The combination of anti-CD34 antibody and DES can not only well offset the short-term inhibitory effect on re-endothelialization but also slightly enhance the long-term antiproliferative effect.
authors.affiliation: The 1st Ward of Beijing Anzhen Hospital Affiliated by Capital Medical University, Beijing 100029, China.
authors.forename: Xing-Sheng
authors.initials: XS
authors.lastname: Yang
authors.forename: Hua-Gang
authors.initials: HG
authors.lastname: Zhu
authors.forename: Zhan-Jiang
authors.initials: ZJ
authors.lastname: Yu
authors.forename: Fang
authors.initials: F
authors.lastname: Ren
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Chen
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.forename: Zheng-Cai
authors.initials: ZC
authors.lastname: Zhang
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Lu
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D018952:Antigens, CD34 / Q000276:immunology*; D002317:Cardiovascular Agents / Q000008:administration & dosage; D049109:Cell Proliferation / Q000187:drug effects; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D054855:Drug-Eluting Stents; D006965:Hyperplasia; D008670:Metals; D008855:Microscopy, Electron, Scanning; D058426:Neointima / Q000209:etiology / Q000517:prevention & control; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D041623:Tomography, Optical Coherence
chemical_list: D000906:Antibodies; D018952:Antigens, CD34; D002317:Cardiovascular Agents; D008670:Metals; D020123:Sirolimus