title: Castleman disease and associated autoimmune disease.
abstract: OBJECTIVE
  Castleman disease can occur in association with autoimmune connective tissue disease and confound the clinical picture, resulting in delayed diagnosis and suboptimal treatment. This review focuses on the intersection of Castleman disease and autoimmunity with an emphasis on shared pathology and mutually beneficial treatments.
  
  
  RESULTS
  Targeting CD-20, interleukin-6, and the nuclear factor-κB pathway has shown promise in achieving long-term remission in patients with Castleman disease and associated autoimmune features.
  
  
  CONCLUSIONS
  Advances in understanding of pathogenic cell types and cytokines in Castleman disease have allowed the development of targeted therapies successful in the treatment of both Castleman disease and associated autoimmune disease.
authors.affiliation: Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Theresa W
authors.initials: TW
authors.lastname: Muskardin
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Peterson
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Molitor
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans