title: PubChem's BioAssay Database.
abstract: PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activity data of small molecules and RNAi reagents. The mission of PubChem is to deliver free and easy access to all deposited data, and to provide intuitive data analysis tools. The PubChem BioAssay database currently contains 500,000 descriptions of assay protocols, covering 5000 protein targets, 30,000 gene targets and providing over 130 million bioactivity outcomes. PubChem's bioassay data are integrated into the NCBI Entrez information retrieval system, thus making PubChem data searchable and accessible by Entrez queries. Also, as a repository, PubChem constantly optimizes and develops its deposition system answering many demands of both high- and low-volume depositors. The PubChem information platform allows users to search, review and download bioassay description and data. The PubChem platform also enables researchers to collect, compare and analyze biological test results through web-based and programmatic tools. In this work, we provide an update for the PubChem BioAssay resource, including information content growth, data model extension and new developments of data submission, retrieval, analysis and download tools.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. ywang@ncbi.nlm.nih.gov
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.forename: Jewen
authors.initials: J
authors.lastname: Xiao
authors.forename: Tugba O
authors.initials: TO
authors.lastname: Suzek
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiyao
authors.initials: J
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Lianyi
authors.initials: L
authors.lastname: Han
authors.forename: Karen
authors.initials: K
authors.lastname: Karapetyan
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dracheva
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Shoemaker
authors.forename: Evan
authors.initials: E
authors.lastname: Bolton
authors.forename: Asta
authors.initials: A
authors.lastname: Gindulyte
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Bryant
mesh_terms: D001681:Biological Assay; D016208:Databases, Factual; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D007202:Indicators and Reagents; D015394:Molecular Structure; D034622:RNA Interference; D012984:Software
chemical_list: D007202:Indicators and Reagents