title: [Pathogenesis of type 1 and type 2 diabetes in 2011--the unifying model of glucoregulation disorder].
abstract: Present knowledge on pathogenic mechanisms in type 1 and type 2 diabetes mellitus may offer the identical scheme of the cascade steps disturbing B-cell and its organells. The only one difference is based in the initiation of the whole cascade by cytokines activated in previous infection (Type 1 DM) or by increased concentration of free fatty acids (Type 2 DM) in the individuals with different genetic background for both types of diabetes. Impaired function and structure of mitochondria causes cell failure and its following apoptosis. The elucidation of the cause of changes in developed diabetes enables to suggest some perspective therapeutic approaches and/or preventive ways.
authors.affiliation: III. interní klinika-klinika endokrinologie a metabolizmu 1. lékarské fakulty UK a VFN Praha. jan.skrha@lf1.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Skrha
mesh_terms: D017209:Apoptosis; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology