title: Effect of beta blockade on natriuretic peptides and copeptin in elderly patients with heart failure and preserved or reduced ejection fraction: results from the CIBIS-ELD trial.
abstract: BACKGROUND
  We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF).
  
  
  METHODS
  Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF.
  
  
  RESULTS
  After initial increasing trend of NT-proBNP at 6 weeks in HFREF patients, there was a subsequent decrease at 12 weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12 weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12 weeks of BB up-titration.
  
  
  CONCLUSIONS
  After 12 weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF.
authors.affiliation: Zvezdara University Medical Center, Department of cardiology, Dimitrija Tucovica 161, 11 000 Belgrade, Serbia. loncar_goran@yahoo.com
authors.forename: Goran
authors.initials: G
authors.lastname: Loncar
authors.forename: Stephan
authors.initials: S
authors.lastname: von Haehling
authors.forename: Elvis
authors.initials: E
authors.lastname: Tahirovic
authors.forename: Simone
authors.initials: S
authors.lastname: Inkrot
authors.forename: Meinhard
authors.initials: M
authors.lastname: Mende
authors.forename: Nikola
authors.initials: N
authors.lastname: Sekularac
authors.forename: Mitja
authors.initials: M
authors.lastname: Lainscak
authors.forename: Svetlana
authors.initials: S
authors.lastname: Apostolovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Putnikovic
authors.forename: Frank
authors.initials: F
authors.lastname: Edelmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Wachter
authors.forename: Sinisa
authors.initials: S
authors.lastname: Dimkovic
authors.forename: Finn
authors.initials: F
authors.lastname: Waagstein
authors.forename: Götz
authors.initials: G
authors.lastname: Gelbrich
authors.forename: Hans-Dirk
authors.initials: HD
authors.lastname: Düngen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism; D004311:Double-Blind Method; D004452:Echocardiography / Q000379:methods; D005260:Female; D006020:Glycopeptides / Q000096:biosynthesis*; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis*; D010446:Peptide Fragments / Q000096:biosynthesis*; D012372:ROC Curve; D015203:Reproducibility of Results; D015854:Up-Regulation
chemical_list: D000319:Adrenergic beta-Antagonists; D015415:Biomarkers; D006020:Glycopeptides; D010446:Peptide Fragments; C048197:copeptins; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain