title: Body weight reducing effect of oral boric acid intake.
abstract: BACKGROUND
  Boric acid is widely used in biology, but its body weight reducing effect is not researched.
  
  
  METHODS
  Twenty mice were divided into two equal groups. Control group mice drank standard tap water, but study group mice drank 0.28mg/250ml boric acid added tap water over five days. Total body weight changes, major organ histopathology, blood biochemistry, urine and feces analyses were compared.
  
  
  RESULTS
  Study group mice lost body weight mean 28.1% but in control group no weight loss and also weight gained mean 0.09% (p<0.001). Total drinking water and urine outputs were not statistically different. Cholesterol, LDL, AST, ALT, LDH, amylase and urobilinogen levels were statistically significantly high in the study group. Other variables were not statistically different. No histopathologic differences were detected in evaluations of all resected major organs.
  
  
  CONCLUSIONS
  Low dose oral boric acid intake cause serious body weight reduction. Blood and urine analyses support high glucose, lipid and middle protein catabolisms, but the mechanism is unclear.
authors.affiliation: Department of General Surgery, Bezmialem Vakif University, Turkey. dr@webcerrah.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Aysan
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Sahin
authors.forename: Dilek
authors.initials: D
authors.lastname: Telci
authors.forename: Mehmet Emir
authors.initials: ME
authors.lastname: Yalvac
authors.forename: Sinem Hocaoglu
authors.initials: SH
authors.lastname: Emre
authors.forename: Cetin
authors.initials: C
authors.lastname: Karaca
authors.forename: Mahmut
authors.initials: M
authors.lastname: Muslumanoglu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001888:Boric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D001888:Boric Acids; C032688:boric acid