title: Gender influences outcomes in trauma patients with elevated systolic blood pressure.
abstract: BACKGROUND
  This analysis explored the association between gender and systolic blood pressure (SBP) in trauma patients and then established how gender influenced outcomes in those with elevated SBP.
  
  
  METHODS
  Demographics and outcomes were compared using the Los Angeles County Trauma System Database and multivariable modeling determined predictors for SBP, pneumonia, and mortality.
  
  
  RESULTS
  Age and male sex were significant predictors for increased SBP, whereas the Injury Severity Score (ISS) ≥16 was a significant predictor for decreased SBP. In both male and female TBI patients, SBP ≥160 mmHg was associated with increased pneumonia (Adjusted odds ratio [AOR] = 1.74, P = .002 and AOR = 2.37, P = .046, respectively), whereas SBP ≥160 mmHg was a predictor for mortality only among male TBI patients (AOR = 1.48, P = .03). In non-TBI patients, SBP ≥160 mmHg was not a predictor for pneumonia or mortality in either sex.
  
  
  CONCLUSIONS
  In this retrospective review of trauma registry data, men presented with higher SBP. In patients with TBI, regardless of gender, increased SBP was associated with increased pneumonia, and in men with TBI increased SBP was associated with increased mortality. The cause and relevance of these epidemiological findings require further investigation.
authors.affiliation: Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Morgan A
authors.initials: MA
authors.lastname: Clond
authors.forename: James
authors.initials: J
authors.lastname: Mirocha
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Singer
authors.forename: Marko
authors.initials: M
authors.lastname: Bukur
authors.forename: Ali
authors.initials: A
authors.lastname: Salim
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Marguiles
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Ley
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001930:Brain Injuries / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D015601:Injury Severity Score; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate / Q000639:trends