title: Prognostic significance of Dicer cellular levels in soft tissue sarcomas.
abstract: In the present study we assessed the expression and distribution of endoribonuclease Dicer in soft tissue tumors and correlated its cellular levels with clinicopathological parameters, including clinical outcome. Dicer was expressed in the tested cell line as well as in the majority of the sarcomas examined. Staining intensity was significantly higher in sarcomas compared with benign neoplasms and in high-grade compared with low-grade tumors. Elevated Dicer immunoreactivity was strongly associated with poor outcome and Dicer cellular levels were an independent negative prognostic factor.
authors.affiliation: Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, School of Medicine, University of Patras, Patras, Greece. papachristoudj@med.upatras.gr
authors.forename: Dionysios J
authors.initials: DJ
authors.lastname: Papachristou
authors.forename: Uma N M
authors.initials: UN
authors.lastname: Rao
authors.forename: Angeliki
authors.initials: A
authors.lastname: Korpetinou
authors.forename: Efstathia
authors.initials: E
authors.lastname: Giannopoulou
authors.forename: Emilia
authors.initials: E
authors.lastname: Sklirou
authors.forename: Vasileios
authors.initials: V
authors.lastname: Kontogeorgakos
authors.forename: Haralabos P
authors.initials: HP
authors.lastname: Kalofonos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D043244:Ribonuclease III / Q000378:metabolism*; D012983:Soft Tissue Neoplasms / Q000201:enzymology* / Q000473:pathology; D055815:Young Adult
chemical_list: C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases