title: Auditory brainstem evoked responses in hyperlipidaemia: effect of various lipid fractions on auditory function.
abstract: OBJECTIVE
  To evaluate the effect of different lipid fractions on auditory brainstem evoked responses in hyperlipidaemia.
  
  
  METHODS
  We conducted a single institution (medical college), prospective, cross-sectional study of 25 hyperlipidaemic patients and 25 normolipidaemic controls, all with a normal hearing threshold on pure tone audiometry. Brainstem evoked response audiometry results were recorded in both groups. The hyperlipidaemic group were further divided into two subgroups, based on the serum value of each lipid fraction: those with less than and those with greater than the mean serum value. These two subgroups were further compared with the control group.
  
  
  RESULTS
  The hyperlipidaemic and normolipidaemic groups had statistically significant differences for all audiometry waves apart from the wave I and the III-V interpeak latencies. The subgroups had a statistically significant difference in brainstem evoked responses. We found a statistically significant association between low-density lipoproteins and many waveforms in the hyperlipidaemic group.
  
  
  CONCLUSIONS
  We found that low-density lipoproteins were significantly associated with many waveforms in hyperlipidaemic patients. Thus, low-density lipoproteins may be important in auditory dysfunction.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India. anujagdeep@yahoo.co.in
authors.forename: J S
authors.initials: JS
authors.lastname: Thakur
authors.forename: N K
authors.initials: NK
authors.lastname: Mohindroo
authors.forename: M S
authors.initials: MS
authors.lastname: Vasanthalakshmi
authors.forename: N
authors.initials: N
authors.lastname: Kashyap
authors.forename: R K
authors.initials: RK
authors.lastname: Azad
authors.forename: D R
authors.initials: DR
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D003430:Cross-Sectional Studies; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D008077:Lipoproteins, LDL