title: [Evaluation of atypical semen parameters in individuals whose couples had a history of early recurrent embryo death: in search for a reference value].
abstract: BACKGROUND
  Previous studies related alterations in non-conventional seminal parameters with recurrent early embryonic death for one couple. A reference standard of clinical assessment is required for the management of these kinds of patients.
  
  
  OBJECTIVE
  Normal semen parameters were established based on functional tests including lipid peroxidation of sperm membranes, antioxidant capacity of seminal plasma and integrity of sperm chromatin to compare with men whose partners have recurrent early embryonic death. These parameters set reference values to identify subfertile individuals whose condition can be attributed to altered semen parameters.
  
  
  METHODS
  The conventional and non-conventional semen parameters of 47 samples of semen were evaluated. Thirty-six samples were from subfertile individuals whose partners had a history of early recurrent embryo death, and 11 samples were from individuals with recent evidence of normal fertility.
  
  
  RESULTS
  By discriminant analysis, the two groups were classified as follows: a value below 0.50 for 86.1% of individuals in the group of recurrent early embryonic death, and a value above 0.50 to classify 81.8% of individuals in the group of recent fertility.
  
  
  CONCLUSIONS
  This reference value of 0.5 based on the results of sperm tests can identify infertile male patients whose partners have a history of early embryonic death. This will aid the physician to suggest treatments more focused on the possible cause of subfertility.
authors.affiliation: Grupo Reproducción, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Edisson
authors.initials: E
authors.lastname: Rodríguez
authors.forename: Aura María
authors.initials: AM
authors.lastname: Gil-Villa
authors.forename: Daniel Camilo
authors.initials: DC
authors.lastname: Aguirre-Acevedo
authors.forename: Walter
authors.initials: W
authors.lastname: Cardona-Maya
authors.forename: Angela P
authors.initials: AP
authors.lastname: Cadavid
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D020964:Embryo Loss / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology; D007248:Infertility, Male / Q000503:physiopathology; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D025341:Principal Component Analysis; D012016:Reference Values; D012661:Semen / Q000737:chemistry* / Q000166:cytology; D013094:Spermatozoa / Q000002:abnormalities* / Q000737:chemistry / Q000166:cytology*; D055815:Young Adult
chemical_list: D000975:Antioxidants