title: [Estimation of genetic safety of nanomaterials].
abstract: Problems pertaining to the estimation of genetic safety of nanomaterials are considered. Comparative analysis of current approaches to testing mutagenicity in this country and abroad is presented. The necessity of mandatory evaluation of genotoxic and mutagenic properties of modern nanomaterials in accordance with international standards is substantiated. The system of the existing methods for the purpose should be supplemented by new scientifically sound and verified techniques. Methodological peculiarities of the assessment of organ-specific nanomaterials are described. It is recommended to correct certain provisions of the approved Guidelines 1.2.2520-09 concerning mutagenic properties of nanomaterials.
authors.forename: L P
authors.initials: LP
authors.lastname: Sycheva
authors.forename: V S
authors.initials: VS
authors.lastname: Zhurkov
mesh_terms: D032761:Animal Experimentation; D015197:Carcinogenicity Tests / Q000592:standards; D017408:Guidelines as Topic; D006801:Humans; D007391:International Cooperation; D016296:Mutagenesis; D009152:Mutagenicity Tests / Q000592:standards; D049329:Nanostructures / Q000009:adverse effects / Q000032:analysis*; D036103:Nanotechnology; D012449:Safety