title: Synthesis and bioactive studies of complex 8-hydroxyquinolinato-bis-(salicylato) yttrium (III).
abstract: This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power-time curves of the compounds HSAY, C(7)H(6)O(3), C(9)H(7)NO, and YCl(3)·6H(2)O on the growth metabolism of Schizosaccharomyces pombe (S. pombe) were determined at 32.00°C, respectively. The corresponding thermokinetics parameters, which include the microbial growth rate constant (κ), inhibition ratio (I), and half inhibition concentration (IC(50)), were also derived. The results showed that the generation time was 168.2 min, and all the compounds HSAY, C(7)H(6)O(3), C(9)H(7)NO, and YCl(3)·6H(2)O possessed good bioactivities on the growth metabolism of S. pombe, with the values of IC(50) being 0.055, 3.57, 0.057, and 1.35 mmol L(-1), respectively. The inhibition ability of these compounds above on the growth of the S. pombe has been observed to decrease in the order HSAY>C(9)H(7)NO>YCl(3)·6H(2)O>C(7)H(6)O(3).
authors.affiliation: Department of Chemistry and Life Science, Xiangnan University, Chenzhou, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.forename: Qiang-Guo
authors.initials: QG
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Hu
authors.forename: Fei-Hong
authors.initials: FH
authors.lastname: Yao
authors.forename: De-Jun
authors.initials: DJ
authors.lastname: Yang
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Xiao
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Ye
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Dong-Cai
authors.initials: DC
authors.lastname: Guo
mesh_terms: D000465:Algorithms; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D008954:Models, Biological; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017378:Quinolinic Acid / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry*; D012568:Schizosaccharomyces / Q000187:drug effects / Q000254:growth & development; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D015019:Yttrium / Q000737:chemistry*
chemical_list: C477453:6-hydroxyquinolinic acid; D009942:Organometallic Compounds; D012459:Salicylates; D015019:Yttrium; D017378:Quinolinic Acid