title: Clear-cell papulosis: a rare entity that may be misconstrued pathologically as normal skin.
abstract: We describe a case of multiple, discrete, hypopigmented macules in the suprapubic and axillary region in a healthy 3-year-old girl. The lesions first appeared at approximately 9 months of age and increased in number over time. Initial histopathologic examination by an outside dermatopathologist at 1 year of age was reported as showing nonspecific histologic changes. A repeat biopsy at 3 years of age showed large intraepidermal clear cells that expressed CKAE1/CAM5.2, CK7, and BRST2. These findings are diagnostic for clear-cell papulosis, a rare condition that primarily affects children. Without great clinical and pathologic suspicion, this is a diagnosis that can often be overlooked because the histologic findings are virtually identical to those of normal skin.
authors.affiliation: Department of Dermatology, School of Medicine, Stanford University, Stanford, California 94305, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Wysong
authors.forename: Uma
authors.initials: U
authors.lastname: Sundram
authors.forename: Latanya
authors.initials: L
authors.lastname: Benjamin
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002352:Carrier Proteins / Q000032:analysis; D002675:Child, Preschool; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D017496:Hypopigmentation / Q000188:drug therapy / Q000473:pathology*; D007093:Imidazoles / Q000627:therapeutic use; D053552:Keratin-7 / Q000032:analysis; D007633:Keratins / Q000032:analysis; D026901:Membrane Transport Proteins; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C400901:CAM 5.2 antigen; D002352:Carrier Proteins; D003879:Dermatologic Agents; D006023:Glycoproteins; D007093:Imidazoles; C507497:KRT7 protein, human; D053552:Keratin-7; D026901:Membrane Transport Proteins; C488892:PIP protein, human; D007633:Keratins; C022155:oxiconazole; D006854:Hydrocortisone