title: Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant.
abstract: Peripheral T-cell non-Hodgkin lymphomas (T-NHL) are rare diseases, with a worse prognosis compared to their B-cell counterparts. Allogeneic hematopoietic stem cell transplant may have a role in the treatment of relapsed/refractory disease or high-risk histologies in the upfront setting. However, there is limited information on the efficacy of allogeneic transplant for these diseases, as well as what factors may predict outcomes. We therefore performed a retrospective study of 34 patients who received an allogeneic transplant for the treatment of T-NHL at a single center between 1 January 1992 and 31 December 2009. The median follow-up for survivors was 45 months (range 9-160 months). The 2-year overall survival (OS) was 0.61 (95% confidence interval [CI]: 0.43-0.75) with a plateau at 28 months. Ki-67 expression ≤ 25% was predictive of improved OS (p < 0.01), and transplant in complete remission was predictive of a decreased cumulative incidence of events (p = 0.04). Three patients received a donor leukocyte infusion, and two patients demonstrated a response, supporting a graft-versus-lymphoma effect. These data demonstrate that allogeneic transplant is a viable option for the treatment of T-NHL and merits prospective evaluation.
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Jenna D
authors.initials: JD
authors.lastname: Goldberg
authors.affiliation: Department of Biostatistics and Epidemiology; Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Chou
authors.affiliation: Lymphoma Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Steven
authors.initials: S
authors.lastname: Horwitz
authors.affiliation: Department of Pathology; Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: Julie
authors.initials: J
authors.lastname: Teruya-Feldstein
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Juliet N
authors.initials: JN
authors.lastname: Barker
authors.affiliation: Bone Marrow Transplantation Service, Department of Pediatrics; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Farid
authors.initials: F
authors.lastname: Boulad
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Hugo
authors.initials: H
authors.lastname: Castro-Malaspina
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Ann A
authors.initials: AA
authors.lastname: Jakubowski
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Guenther
authors.initials: G
authors.lastname: Koehne
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Marcel R M
authors.initials: MRM
authors.lastname: van den Brink
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: James W
authors.initials: JW
authors.lastname: Young
authors.affiliation: Department of Biostatistics and Epidemiology; Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Esperanza B
authors.initials: EB
authors.lastname: Papadopoulos
authors.affiliation: Adult Bone Marrow Transplantation Service; Memorial Sloan-Kettering Cancer Center, New York, NY.|Department of Medicine; Memorial Sloan-Kettering Cancer Center, New York, NY.|Weill Cornell Medical College; New York, NY.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D016411:Lymphoma, T-Cell, Peripheral / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data*; D013997:Time Factors; D014184:Transplantation, Homologous; D055815:Young Adult