title: Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
abstract: BACKGROUND
  Human chromosomal region 8q24 contains several genes which could be functionally related to cancer, including the proto-oncogene c-MYC. However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24.
  
  
  METHODS
  In this study, we completed a meta-analysis of results from nine genome-wide association studies for seven types of solid-tumor cancers (breast, prostate, pancreatic, lung, ovarian, colon, and glioma) to identify additional associations that were not apparent in any individual study.
  
  
  RESULTS
  Fifteen SNPs in the 8q24 region had meta-analysis p-values < 1E-04. In particular, the region consisting of 120,576,000-120,627,000 bp contained 7 SNPs with p-values < 1.0E-4, including rs6993464 (p = 1.25E-07). This association lies in the region between two genes, NOV and ENPP2, which have been shown to play a role in tumor development and motility. An additional region consisting of 5 markers from 128,478,000 bp - 128,524,000 (around gene POU5F1B) had p-values < 1E-04, including rs6983267, which had the smallest p-value (p = 6.34E-08). This result replicates previous reports of association between rs6983267 and prostate and colon cancer.
  
  
  CONCLUSIONS
  Further research in this area is warranted as these results demonstrate that the chromosomal region 8q24 may contain a locus that influences general cancer susceptibility between 120,576 and 120,630 kb.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, USA.
authors.forename: Abra G
authors.initials: AG
authors.lastname: Brisbin
authors.forename: Yan W
authors.initials: YW
authors.lastname: Asmann
authors.forename: Honglin
authors.initials: H
authors.lastname: Song
authors.forename: Ya-Yu
authors.initials: YY
authors.lastname: Tsai
authors.forename: Jeremiah A
authors.initials: JA
authors.lastname: Aakre
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Robert B
authors.initials: RB
authors.lastname: Jenkins
authors.forename: Paul
authors.initials: P
authors.lastname: Pharoah
authors.forename: Fredrick
authors.initials: F
authors.lastname: Schumacher
authors.forename: David V
authors.initials: DV
authors.lastname: Conti
authors.forename: David J
authors.initials: DJ
authors.lastname: Duggan
authors.forename: Mark
authors.initials: M
authors.lastname: Jenkins
authors.forename: John
authors.initials: J
authors.lastname: Hopper
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: Polly
authors.initials: P
authors.lastname: Newcomb
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sellers
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Fridley
mesh_terms: D002898:Chromosomes, Human, Pair 8; D018450:Disease Progression; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D055514:Nephroblastoma Overexpressed Protein / Q000235:genetics; D010727:Phosphoric Diester Hydrolases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D000090063:Proto-Oncogene Mas; D000099189:Lysophospholipase D
chemical_list: D055514:Nephroblastoma Overexpressed Protein; D010727:Phosphoric Diester Hydrolases; D000090063:Proto-Oncogene Mas; D000099189:Lysophospholipase D; C526319:CCN3 protein, human; C000715470:MAS1 protein, human