title: [Aneugenic effect of ionizing radiation: a new component in the estimation of genotoxic risks].
abstract: Assessment of genetic risks related to effects of ionizing radiation on the human body remains a topical problem in medical genetics. Along with numerous data about the influence of radiation on chromosomes of man and model organisms, there are some facts suggesting possible aneugenic effect in addition to the well-known clastogenic influence generally recognized as a marker for biological dosimetry. The interest in genetic risks of aneuploidy is in the first place due to its gross mutagenic potential. Simultaneous changes in a large number of gene copies are regarded as an important contributing factor of malignant cell transformation and tumour growth. The role of aneuploidy in aging and multifactorial diseases is discussed and some data suggesting aneugenic effect of ionizing radiation are presented. The potential significance of aneuploidy for risk assessment of mutagenic factors is considered.
authors.forename: I N
authors.initials: IN
authors.lastname: Lebedev
authors.forename: V A
authors.initials: VA
authors.lastname: Timoshevskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
mesh_terms: D000375:Aging / Q000235:genetics / Q000528:radiation effects; D000782:Aneuploidy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000528:radiation effects; D004249:DNA Damage; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics / Q000528:radiation effects; D016296:Mutagenesis; D009152:Mutagenicity Tests; D011839:Radiation, Ionizing; D018570:Risk Assessment; D012307:Risk Factors