title: Comparison of serum creatinine and cystatin C for early diagnosis of contrast-induced nephropathy after coronary angiography and interventions.
abstract: BACKGROUND
  The diagnostic accuracy of serum creatinine and cystatin C (Cys) as early predictors of contrast-induced nephropathy (CIN) has been debated. We investigated the diagnostic sensitivities, diagnostic specificities, and variations from baseline for serum creatinine and Cys in CIN.
  
  
  METHODS
  We prospectively evaluated 166 patients at risk for CIN at baseline, and at 12, 24, and 48 h after exposure to contrast media. CIN occurred in 30 patients (18%). Changes (Δ) compared to baseline in serum creatinine and Cys were evaluated at the predefined time points. ROC curve analysis was performed for the Δ 12-h basal serum creatinine and Cys.
  
  
  RESULTS
  The Δ serum creatinine at 12 h from baseline was the earliest predictor of CIN [area under the ROC curve (AUC) = 0.80; P < 0.001]. The Δ serum creatinine 15% variation [0.15 mg/dL (13.2 μmol/L)] yielded 43% diagnostic sensitivity and 93% diagnostic specificity. The ΔCys at 12 h from baseline performed significantly worse than serum creatinine (AUC = 0.48; P = 0.74).
  
  
  CONCLUSIONS
  Variations from the serum creatinine baseline offer better diagnostic accuracy for predicting CIN at an earlier stage than similar variations in Cys. An additional diagnostic value of Cys over the determination of serum creatinine in the setting of CIN was not observed.
authors.affiliation: Department of Medicine, Division of Cardiology, University of Verona, Verona, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Ribichini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gambaro
authors.forename: Maria Stella
authors.initials: MS
authors.lastname: Graziani
authors.forename: Michele
authors.initials: M
authors.lastname: Pighi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Pesarini
authors.forename: Paolo
authors.initials: P
authors.lastname: Pasoli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Anselmi
authors.forename: Valeria
authors.initials: V
authors.lastname: Ferrero
authors.forename: Tewoldemedhn
authors.initials: T
authors.lastname: Yabarek
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sorio
authors.forename: Paolo
authors.initials: P
authors.lastname: Rizzotti
authors.forename: Antonio
authors.initials: A
authors.lastname: Lupo
authors.forename: Corrado
authors.initials: C
authors.lastname: Vassanelli
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis*; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D055316:Cystatin C; D003404:Creatinine