title: The serum level of fibroblast growth factor-23 and calcium-phosphate homeostasis in obese perimenopausal women.
abstract: Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D(3), CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed. DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD). Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur (R = -0.346; R = 0.285, resp.) but not with markers of bone turnover. However, serum phosphorus level in obese subjects was significantly lower. iFGF-23 concentration correlated significantly with body mass index (R = 0.292) and fat content (R = 0.259) in all study subjects. Moreover, a significant correlation between iFGF-23 and iPTH (R = 0.254) was found. No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found. Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover.
authors.affiliation: Department of Internal Medicine and Metabolic Diseases, Medical University of Silesia, ul. Ziołowa 45/47, 40-635 Katowice, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Holecki
authors.forename: J
authors.initials: J
authors.lastname: Chudek
authors.forename: A
authors.initials: A
authors.lastname: Więcek
authors.forename: M
authors.initials: M
authors.lastname: Titz-Bober
authors.forename: J
authors.initials: J
authors.lastname: Duława