title: Association of mean platelet volume with DSM-IV major depression in a large community-based population: the MELEN study.
abstract: The relationship between major depression and increased platelet activity has been previously stated by several studies. This study sought to test the relationship between mean platelet volume (MPV)--an indicator of platelet activity--and major depression, in an adult Turkish population sample. Respondents were 2286 participants interviewed in a regional survey. The diagnosis of current (one month) major depression was made according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. MPV was measured along with total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, BMI, and waist circumference. Two hundred eighty-nine participants (12.5%) were diagnosed as having major depression. Patients with major depression were found to have increased MPV levels in comparison with participants without depression (p = 0.001). After excluding the subjects with risk factors capable of influencing platelet activity, MPV was still found to be elevated in patients with major depression compared with non-depressed individuals (p < 0.01). Linear regression analysis revealed a significant independent association of major depression with MPV levels (r = 0.123; p = 0.001). According to the findings of this study, increased MPV (or platelet activation) is associated with current (one month) diagnosis of major depression. Future research should investigate the effect of depression treatment on MPV.
authors.affiliation: Bolu Izzet Baysal Mental Health Hospital, 14000 Bolu, Turkey. fatihcanan@gmail.com
authors.forename: Fatih
authors.initials: F
authors.lastname: Canan
authors.forename: Suber
authors.initials: S
authors.lastname: Dikici
authors.forename: Ali
authors.initials: A
authors.lastname: Kutlucan
authors.forename: Gokhan
authors.initials: G
authors.lastname: Celbek
authors.forename: Hulya
authors.initials: H
authors.lastname: Coskun
authors.forename: Adem
authors.initials: A
authors.lastname: Gungor
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Aydin
authors.forename: Gulsen
authors.initials: G
authors.lastname: Kocaman
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology*; D015992:Body Mass Index; D048429:Cell Size; D002784:Cholesterol / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D002784:Cholesterol