title: Tolerance induced by anti-DNA Ig peptide in (NZB×NZW)F1 lupus mice impinges on the resistance of effector T cells to suppression by regulatory T cells.
abstract: We have previously shown that immune tolerance induced by the anti-DNA Ig peptide pCons in (NZB×NZW)F(1) (NZB/W) lupus mice prolonged survival of treated animals and delayed the appearance of autoantibodies and glomerulonephritis. Part of the protection conferred by pCons could be ascribed to the induction of regulatory T cells (T(Reg)) that suppressed the production of anti-DNA antibodies in a p38 MAPK-dependent fashion. Here we show that another effect of pCons in the induction of immune tolerance in NZB/W lupus mice is the facilitation of effector T cell suppression by T(Reg). These new findings indicate that pCons exerts protective effects in NZB/W lupus mice by differentially modulating the activity of different T cell subsets, implying new considerations in the design of T(Reg)-based approaches to modulate T cell autoreactivity in SLE.
authors.affiliation: Division of Rheumatology at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Yu
authors.forename: Yaoyang
authors.initials: Y
authors.lastname: Liu
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.forename: Hejian
authors.initials: H
authors.lastname: Zou
authors.forename: Bevra H
authors.initials: BH
authors.lastname: Hahn
authors.forename: Antonio
authors.initials: A
authors.lastname: La Cava
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D010455:Peptides