title: Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test.
abstract: BACKGROUND
  Delayed gastric emptying is a non-motor symptom of Parkinson's disease. Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated.
  
  
  METHODS
  Twenty healthy controls, 13 patients with idiopathic rapid-eye-movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the (13)C-octanoate breath test.
  
  
  RESULTS
  Gastric emptying was significantly delayed in drug-naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid-eye-movement sleep behavior disorder.
  
  
  CONCLUSIONS
  Our study confirms delayed gastric emptying in drug-naïve, early-stage Parkinson's disease. Normal gastric emptying in idiopathic rapid-eye-movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the (13)C-octanoate breath test.
authors.affiliation: Department of Neurology, Philipps-University Marburg, Marburg, Germany. marcus.unger@med.uni-marburg.de
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Unger
authors.forename: Jens C
authors.initials: JC
authors.lastname: Möller
authors.forename: Katharina
authors.initials: K
authors.lastname: Mankel
authors.forename: Katrin
authors.initials: K
authors.lastname: Schmittinger
authors.forename: Karla M
authors.initials: KM
authors.lastname: Eggert
authors.forename: Maria
authors.initials: M
authors.lastname: Stamelou
authors.forename: Karin
authors.initials: K
authors.lastname: Stiasny-Kolster
authors.forename: Katharina
authors.initials: K
authors.lastname: Bohne
authors.forename: Maren
authors.initials: M
authors.lastname: Bodden
authors.forename: Geert
authors.initials: G
authors.lastname: Mayer
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Tebbe
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods*; D002210:Caprylates / Q000493:pharmacokinetics; D002247:Carbon Isotopes; D017615:Enteric Nervous System / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000150:complications* / Q000503:physiopathology; D012680:Sensitivity and Specificity
chemical_list: D002210:Caprylates; D002247:Carbon Isotopes; C031492:octanoic acid