title: Synthesis and antiproliferative activity of some steroidal lactone compounds.
abstract: Using cholesterol as starting material, some steroidal lactone compounds with the structures of 3-substituted-6-oxo-7-oxa-B-homo-cholestane or 3-substituted-7-oxo-6-oxa-B-homo-cholestane were synthesized by oxidation, reduction, Baeyer-Villiger reaction and condensation reaction. The cytotoxicity of these compounds against MGC 7901 (human gastric carcinoma), HeLa (human cervical carcinoma) and SMMC 7404 (human liver carcinoma) cells was investigated. Our results showed that the synthesized compounds displayed a distinct cytotoxicity against these cancer cells. In particular, compounds 8 and 9 have similar cytotoxic capability as cisplatin does. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530022, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gan
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Huang
authors.forename: Linyi
authors.initials: L
authors.lastname: Jia
authors.forename: Wanxin
authors.initials: W
authors.lastname: Wei
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy; D002776:Cholestanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry; D006367:HeLa Cells; D006718:Homosteroids / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C571971:3-hydroxy-6-oxo-7-oxa-B-homo-5-cholestane; C571970:3-hydroxy-7-oxo-6-oxa-B-homo-5-cholestane; D000970:Antineoplastic Agents; D002776:Cholestanes; D006718:Homosteroids; D007783:Lactones; D013882:Thiosemicarbazones; D002784:Cholesterol