title: Richter syndrome and brain involvement: low-grade lymphoma relapsing as cerebral high-grade lymphoma.
abstract: Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female with previously unknown low-grade NHL, both with initial appearance of neurological symptoms. This report extends the literature of central nervous system RS and particularly highlights the importance of a thorough diagnostic evaluation of patients with low-grade NHL presenting with neurological symptoms.
authors.affiliation: Department of Neurology, Division of Clinical Neurooncology, University of Bonn Medical Center, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Stuplich
authors.forename: Karin
authors.initials: K
authors.lastname: Mayer
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.forename: Sharmilan
authors.initials: S
authors.lastname: Thanendrarajan
authors.forename: Matthias
authors.initials: M
authors.lastname: Simon
authors.forename: Niklas
authors.initials: N
authors.lastname: Schäfer
authors.forename: Martin
authors.initials: M
authors.lastname: Glas
authors.forename: Ingo G H
authors.initials: IG
authors.lastname: Schmidt-Wolf
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence