title: Prilezhaev dihydroxylation of olefins in a continuous flow process.
abstract: Epoxidation of both terminal and non-terminal olefins with peroxy acids is a well-established and powerful tool in a wide variety of chemical processes. In an additional step, the epoxide can be readily converted into the corresponding trans-diol. Batch-wise scale-up, however, is often troublesome because of the thermal instability and explosive character of the peroxy acids involved. This article describes the design and semi-automated optimization of a continuous flow process and subsequent scale-up to preparative production volumes in an intrinsically safe manner.
authors.affiliation: FutureChemistry Holding BV, Toernooiveld 100, 6525 EC Nijmegen, The Netherlands.
authors.forename: Bas A M W
authors.initials: BA
authors.lastname: van den Broek
authors.forename: René
authors.initials: R
authors.lastname: Becker
authors.forename: Florian
authors.initials: F
authors.lastname: Kössl
authors.forename: Mariëlle M E
authors.initials: MM
authors.lastname: Delville
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Nieuwland
authors.forename: Kaspar
authors.initials: K
authors.lastname: Koch
authors.forename: Floris P J T
authors.initials: FP
authors.lastname: Rutjes
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D006900:Hydroxylation; D055616:Microtechnology / Q000379:methods*; D012449:Safety; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
chemical_list: D000475:Alkenes; D004852:Epoxy Compounds; D012997:Solvents