title: Skeletal growth patterns in hereditary multiple exostoses:  a natural history.
abstract: Hereditary multiple exostoses (HME) is a commonly inherited musculoskeletal condition and is associated with a diminished stature. We demonstrated that adults with HME were significantly shorter when compared with a control group (P<0.001); preadolescents, however, were significantly taller than predicted (P=0.01). This was reflected by their height centile; 58% of the adults were under the 25th centile, whereas 53% of the preadolescence group were above the 75th centile. Stature was more severely affected in patients with an EXT1 mutation (P=0.008). This study illustrates a novel age-related growth pattern associated with HME, which is also affected by genotype.
authors.affiliation: Department of Orthopaedics and Trauma, The Royal Infirmary of Edinburgh, Little France, Edinburgh, UK.
authors.forename: Nicholas David
authors.initials: ND
authors.lastname: Clement
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Duckworth
authors.forename: Alexander D L
authors.initials: AD
authors.lastname: Baker
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Porter
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001846:Bone Development / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004392:Dwarfism / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D005097:Exostoses, Multiple Hereditary / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult