title: IgE and chemotherapy.
abstract: The nexus of chemotherapeutic intervention and the immunomodulation of IgE-related phenomena are not well understood. The relationship bears importance in better understanding the causal and/or resultant effects of one on the other and their collective role in the management and sequelae of the cancer patient. This review discusses the relationship of chemotherapy on immunoglobulins with a focus on IgE and other related biological processes including hypersensitivity reactions and proposes models toward effective management of the cancer patient in this regard.
authors.affiliation: Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA. mbluth@med.wayne.edu
authors.forename: Martin H
authors.initials: MH
authors.lastname: Bluth
mesh_terms: D000970:Antineoplastic Agents / Q000276:immunology* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D007073:Immunoglobulin E