title: Agrypnia excitata.
abstract: The concept of Agrypnia excitata (AE) was originally proposed as a concept deriving from the clinical and anatomo-pathological observations obtained in three different diseases, Fatal familial insomnia (FFI), Delirium tremens (DT), and Morvan syndrome (MS). Agrypnia refers to a condition of severely reduced or absent sleep due to organic disorders. Excitata refers to the association of agrypnia with generalized motor and autonomic hyperactivation. AE is a syndrome that has been claimed to relate to a dysfunction in the thalamo-limbic circuits that govern sleep-wake cycles and autonomic activities.
authors.affiliation: IRCCS, Istituto delle Scienze Neurologiche, University of Bologna, Bologna, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Lugaresi
authors.forename: Federica
authors.initials: F
authors.lastname: Provini
authors.forename: Pietro
authors.initials: P
authors.lastname: Cortelli
mesh_terms: D000430:Alcohol Withdrawal Delirium / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D034062:Insomnia, Fatal Familial / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009069:Movement Disorders / Q000503:physiopathology; D020385:Myokymia / Q000503:physiopathology; D012890:Sleep / Q000502:physiology