title: Effects of zinc supplementation on the element distribution in kidney tissue of diabetic rats subjected to acute swimming.
abstract: In this study, we report the effect of zinc supplementation on the distribution of elements in kidney tissue of diabetic rats subjected to acute swimming exercise. Diabetes was induced by two subcutaneous injections of 40 mg/kg of streptozotocin within a 24-h period. Zinc was given intraperitoneally at a dose of 6 mg/kg per day for a period of 4 weeks. The rats (n = 80) were equally divided into eight study groups: controls, zinc-supplemented, swimming, diabetic, zinc-supplemented diabetic, zinc-supplemented swimming, diabetic swimming, and zinc-supplemented diabetic swimming. The levels of lead, cobalt, molybdenum, chromium, boron, magnesium, iron, copper, calcium, zinc, and selenium were determined in the kidney tissue samples by ICP-AES. Higher molybdenum, calcium, zinc, and selenium values were found in both swimming and nonswimming diabetic rats. Significantly higher iron values were found in swimming, diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats (p < 0.001). Diabetic, zinc-supplemented diabetic, diabetic swimming, and zinc-supplemented diabetic swimming rats had the highest copper values. These results show that zinc supplementation normalized the higher levels of molybdenum, calcium, selenium, and iron levels seen in diabetic rats, indicating that zinc may have a regulatory effect on element metabolism in kidney tissue.
authors.affiliation: Department of Biochemistry, Selcuklu School of Medicine, Selçuk University, Konya, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sivrikaya
authors.forename: Mursel
authors.initials: M
authors.lastname: Bicer
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akil
authors.forename: Abdulkerim Kasim
authors.initials: AK
authors.lastname: Baltaci
authors.forename: Rasim
authors.initials: R
authors.lastname: Mogulkoc
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001895:Boron; D002118:Calcium / Q000378:metabolism; D002857:Chromium / Q000378:metabolism; D003035:Cobalt / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology; D019587:Dietary Supplements; D007274:Injections, Intraperitoneal; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007854:Lead / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008982:Molybdenum / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000378:metabolism; D013311:Streptozocin; D013550:Swimming / Q000502:physiology*; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014131:Trace Elements; D002857:Chromium; D007854:Lead; D003035:Cobalt; D013311:Streptozocin; D019287:Zinc Sulfate; D003300:Copper; D008982:Molybdenum; D007501:Iron; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D001895:Boron; D002118:Calcium