title: Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage.
abstract: BACKGROUND
  The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial.
  
  
  RESULTS
  Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in vivo, but increases oxygen and glucose deprivation-induced cell injury in vitro and ischemia-induced brain damage produced by middle cerebral artery occlusion in vivo.
  
  
  CONCLUSIONS
  Taken together, these results indicate that NBO reduces excitotoxin-induced calcium influx and subsequent neuronal degeneration but favors ischemia-induced brain damage and neuronal death. These findings highlight the complexity of the mechanisms involved by the use of NBO in patients suffering acute ischemic stroke.
authors.affiliation: ERT 1083, UMR 6232, Université de Caen Basse Normandie, CNRS, CEA, Centre CYCERON, B,P, 5229, Boulevard Henri Becquerel, 14074 Caen cedex, France. jh.abraini@gmail.com.
authors.forename: Benoit
authors.initials: B
authors.lastname: Haelewyn
authors.forename: Laurent
authors.initials: L
authors.lastname: Chazalviel
authors.forename: Olivier
authors.initials: O
authors.lastname: Nicole
authors.forename: Myriam
authors.initials: M
authors.lastname: Lecocq
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Risso
authors.forename: Jacques H
authors.initials: JH
authors.lastname: Abraini