title: Three-component chiral derivatizing protocols for NMR spectroscopic enantiodiscrimination of hydroxy acids and primary amines.
abstract: The novel three-component chiral derivatization protocols have been derived for (1)H and (19)F NMR spectroscopic discrimination of a series of chiral hydroxy acids by their coordination and self-assembly with optically active α-methylbenzylamine and 2-formylphenylboronic acid. In addition, the optically pure (S)-mandelic acid in combination with 2-formylphenylboronic acid permits visualization of enantiomers of primary amines. These protocols have been demonstrated on enantiodiscrimination of chiral amines and hydroxy acids.
authors.affiliation: Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
authors.forename: Sachin Rama
authors.initials: SR
authors.lastname: Chaudhari
authors.forename: N
authors.initials: N
authors.lastname: Suryaprakash
mesh_terms: D000588:Amines / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D006880:Hydroxy Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013237:Stereoisomerism
chemical_list: C532809:2-formylphenylboronic acid; D000588:Amines; D001547:Benzaldehydes; D001596:Benzylamines; D001897:Boronic Acids; D006880:Hydroxy Acids