title: An assessment of the statistical methods used to analyse toxicology studies.
abstract: The Statisticians in the Pharmaceutical Industry Toxicology Special Interest Group has collated and compared statistical analysis methods for a number of toxicology study types including general toxicology, genetic toxicology, safety pharmacology and carcinogenicity. In this paper, we present the study design, experimental units and analysis methods.
authors.affiliation: Discovery Statistics, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, UK. Philip.Jarvis@AstraZeneca.com
authors.forename: Philip
authors.initials: P
authors.lastname: Jarvis
authors.forename: Jim
authors.initials: J
authors.lastname: Saul
authors.forename: Mike
authors.initials: M
authors.lastname: Aylott
authors.forename: Simon
authors.initials: S
authors.lastname: Bate
authors.forename: Helena
authors.initials: H
authors.lastname: Geys
authors.forename: John
authors.initials: J
authors.lastname: Sherington
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests / Q000706:statistics & numerical data; D005260:Female; D008297:Male; D009152:Mutagenicity Tests / Q000706:statistics & numerical data; D012107:Research Design / Q000706:statistics & numerical data*; D018675:Toxicity Tests / Q000706:statistics & numerical data; D014116:Toxicology / Q000592:standards*