title: Prognostic value of copeptin: one-year outcome in patients with traumatic brain injury.
abstract: High plasma copeptin level has been associated with one-month mortality after traumatic brain injury. However, not much is known regarding its relation with long-term outcome. Thus, we investigated the ability of copeptin to predict 1-year outcome in patients with traumatic brain injury. One hundred and six healthy controls and 106 patients with acute severe traumatic brain injury were included. Plasma samples were obtained on admission. Its concentration was measured by enzyme-linked immunosorbent assay. Forty-eight patients (45.3%) suffered from unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 31 patients (29.2%) died in 1 year after traumatic brain injury. Upon admission, plasma copeptin level in patients was substantially higher than that in healthy controls. A forward stepwise logistic regression selected plasma copeptin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma copeptin level predicted 1-year unfavorable outcome and mortality obviously. The predictive value of the copeptin concentration was thus similar to that of Glasgow Coma Scale score for the prediction of unfavorable outcome and mortality after 1 year. In a combined logistic-regression model, copeptin improved the area under curve of Glasgow Coma Scale score for the prediction of unfavorable outcome and mortality after 1 year, but the differences were not significant. Thus, copeptin level is a useful, complementary tool to predict functional outcome and mortality 1 year after traumatic brain injury.
authors.affiliation: Department of Neurosurgery, Quzhou People's Hospital, 2 Zhongloudi Road, Kecheng District, Quzhou 324000, China.
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Yu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huang
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Dai
authors.forename: Yuan-Qing
authors.initials: YQ
authors.lastname: Jie
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Fan
authors.forename: An
authors.initials: A
authors.lastname: Wu
authors.forename: Yao
authors.initials: Y
authors.lastname: Lv
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Li
authors.forename: Xin-Jiang
authors.initials: XJ
authors.lastname: Yan
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D016896:Treatment Outcome
chemical_list: D006020:Glycopeptides; C048197:copeptins