title: The in vivo adherence intervention for at risk adolescents with asthma: report of a randomized pilot trial.
abstract: OBJECTIVE
  Low-income and minority adolescents are at high risk for poor asthma outcomes, due in part to adherence. We tested acceptability, feasibility, and effect sizes of an adherence intervention for low socioeconomic status (SES) minority youth with moderate- and severe-persistent asthma. Design and Methods Single-site randomized pilot trial: intervention (n = 12; asthma education, motivational interviewing, problem-solving skills training, 1 month cell-phone with tailored text messaging) versus control (n = 14; asthma education; cell-phone without tailored messaging). Calculated effect-sizes of relative change from baseline (1 and 3 months).
  
  
  RESULTS
  Intervention was judged acceptable and feasible by participants. Participants (12-18 years, mean = 15.1, SD = 1.67) were 76.9% African-American, 80.7% public/no insurance. At 1 and 3 months, asthma symptoms (Cohen's d's = 0.40, 0.96) and HRQOL (PedsQL™; Cohen's d's = 0.23, 1.25) had clinically meaningful medium to large effect sizes.
  
  
  CONCLUSIONS
  This intervention appears promising for at-risk youth with moderate- and severe-persistent asthma.
authors.affiliation: Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. michael.seid@cchmc.org
authors.forename: Michael
authors.initials: M
authors.lastname: Seid
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: D'Amico
authors.forename: James W
authors.initials: JW
authors.lastname: Varni
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Munafo
authors.forename: Maria T
authors.initials: MT
authors.lastname: Britto
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Kercsmar
authors.forename: Dennis
authors.initials: D
authors.lastname: Drotar
authors.forename: Eileen C
authors.initials: EC
authors.lastname: King
authors.forename: Lynn
authors.initials: L
authors.lastname: Darbie
mesh_terms: D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000523:psychology*; D001521:Behavior Therapy; D002648:Child; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D054525:Minority Health; D009042:Motivation; D011340:Problem Solving; D011788:Quality of Life; D012923:Social Class; D060145:Text Messaging; D016896:Treatment Outcome; D014505:Urban Population
chemical_list: D018927:Anti-Asthmatic Agents