title: Occupational exposures and cancer of the larynx-systematic review and meta-analysis.
abstract: OBJECTIVE
  To review epidemiologic data on occupational exposures and laryngeal cancer.
  
  
  METHODS
  We performed a systematic literature search and a series of meta-analyses for agents with at least 10 available studies with homogenous exposure.
  
  
  RESULTS
  We analyzed 99 publications. Significantly increased meta-relative risks (meta-RRs) were obtained considering exposure to polycyclic aromatic hydrocarbons (meta-RR 1.29; 95% confidence interval [CI] 1.10 to 1.52), engine exhaust (meta-RR 1.17; 95% CI 1.05 to 1.30), textile dust (meta-RR 1.41; 95% CI 1.09 to 1.83), and working in the rubber industry (meta-RR 1.39; 95% CI 1.13 to 1.71). Exposures to wood dust, formaldehyde, and cement dust were not significantly associated with laryngeal cancer. In regards of the epidemiologic available data, we could not conclude on the role of solvents.
  
  
  CONCLUSIONS
  Further studies should overcome past limitations in terms of exposure characterization, adjustment for confounding, and sample size.
authors.affiliation: Inserm, Center for Research in Epidemiology and Population Health, UMRS 1018, Occupational and Environmental Determinants of Health; and Versailles Saint-Quentin University, UMRS 1018, Villejuif, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paget-Bailly
authors.forename: Diane
authors.initials: D
authors.lastname: Cyr
authors.forename: Danièle
authors.initials: D
authors.lastname: Luce
mesh_terms: D001194:Asbestos / Q000633:toxicity; D003252:Construction Materials / Q000633:toxicity; D004391:Dust; D005260:Female; D005557:Formaldehyde / Q000633:toxicity; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology*; D008297:Male; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012408:Rubber / Q000009:adverse effects; D012997:Solvents / Q000009:adverse effects; D013783:Textile Industry / Q000706:statistics & numerical data; D001335:Vehicle Emissions / Q000633:toxicity; D014934:Wood / Q000009:adverse effects
chemical_list: D004391:Dust; D011084:Polycyclic Aromatic Hydrocarbons; D012997:Solvents; D001335:Vehicle Emissions; D001194:Asbestos; D005557:Formaldehyde; D012408:Rubber