title: Radiation-induced sarcomas.
abstract: Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.
authors.affiliation: Istituto Ortopedico Rizzoli, University of Bologna, Italy.
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Andrea
authors.initials: A
authors.lastname: Angelini
authors.forename: Elisa
authors.initials: E
authors.lastname: Pala
authors.forename: Teresa
authors.initials: T
authors.lastname: Calabro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bianchi
authors.forename: Roberto
authors.initials: R
authors.lastname: Casadei
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D006801:Humans; D015994:Incidence; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D016019:Survival Analysis