title: Three-dimensional evaluation of the lamina cribrosa using spectral-domain optical coherence tomography in glaucoma.
abstract: OBJECTIVE
  To introduce a novel, digital, three-dimensional (3D) reconstruction of the optic nerve head (ONH) and to use this method to evaluate the 3D configuration of the lamina cribrosa (LC) in patients with primary open-angle glaucoma.
  
  
  METHODS
  Optic discs of 137 eyes of 137 patients with open-angle glaucoma were scanned with enhanced depth-imaging spectral domain-optical coherence tomography (SD-OCT). 3D images of the ONH were then reconstructed from B-scan images using maximum intensity projection (MIP) and texture-based volume rendering (VRT). The performance of the threshold segmentation by MIP and VRT was assessed by comparing the distance of the anterior LC surface from the reference line set at the Bruch's membrane opening level (LC depth) measured within both of the 3D images and the B-scan images.
  
  
  RESULTS
  The LC configuration could be evaluated three dimensionally in ∼95% of patients scanned with enhanced depth-imaging SD-OCT. The mean LC depth was 559.50 ± 151.98, 558.97 ± 152.39, and 560.22 ± 152.26 μm in B-scan, MIP, and VRT images, respectively. There were excellent agreements between the values (intraclass correlation coefficient = 1.000 between MIP and B-scan, and 0.999 between VRT and B-scan). The configuration of the LC varied considerably among individual glaucoma patients.
  
  
  CONCLUSIONS
  This method provides measurable 3D images of the LC that enable comprehensive evaluation of the LC configuration. This technique should facilitate the investigation of the LC in glaucomatous eyes.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Lee
authors.forename: Tae-Woo
authors.initials: TW
authors.lastname: Kim
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Suh
authors.forename: Myungjoo
authors.initials: M
authors.lastname: Kang
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Seok Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult