title: Logical modelling of gene regulatory networks with GINsim.
abstract: Discrete mathematical formalisms are well adapted to model large biological networks, for which detailed kinetic data are scarce. This chapter introduces the reader to a well-established qualitative (logical) framework for the modelling of regulatory networks. Relying on GINsim, a software implementing this logical formalism, we guide the reader step by step towards the definition and the analysis of a simple model of the lysis-lysogeny decision in the bacteriophage λ.
authors.affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal. chaouira@igc.gulbenkian.pt
authors.forename: Claudine
authors.initials: C
authors.lastname: Chaouiya
authors.forename: Aurélien
authors.initials: A
authors.lastname: Naldi
authors.forename: Denis
authors.initials: D
authors.lastname: Thieffry
mesh_terms: D001433:Bacteriolysis / Q000235:genetics; D010582:Bacteriophage lambda / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics*; D008242:Lysogeny / Q000235:genetics; D055641:Mathematical Concepts; D008957:Models, Genetic; D012984:Software; D049490:Systems Biology / Q000379:methods*