title: Regio selective functionalisation of gold nanoparticles with DNA.
abstract: Suspensions of electrocatalytic gold nanoparticles with radii as small as 83 ± 13 nm that are functionalised with DNA only in one region have been created using templated electrodeposition. The integrity of the bound DNA following nanoparticle desorption from the electrode is demonstrated by detecting picomolar concentrations of DNA without the need for molecular, e.g., PCR or NASBA, amplification.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors.forename: Elaine
authors.initials: E
authors.lastname: Spain
authors.forename: Brianna
authors.initials: B
authors.lastname: Miner
authors.forename: Tia E
authors.initials: TE
authors.lastname: Keyes
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Forster
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis / Q000737:chemistry*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D013211:Staphylococcus aureus
chemical_list: D004269:DNA, Bacterial; D006046:Gold; D006735:Horseradish Peroxidase