title: Antioxidant-enriched diet does not delay the progression of age-related hearing loss.
abstract: Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study, 10-month-old female CBA/J mice were placed on either a control or antioxidant-enriched diet and monitored through 24 months of age. Supplementation with vitamins A, C, and E, L-carnitine, and α-lipoic acid significantly increased the antioxidant capacity of inner ear tissues. However, by 24 months of age, the magnitude of hearing loss was equal between the two groups. Likewise, there were no significant differences in hair cell loss or degeneration of spiral ganglion cells. We conclude that dietary manipulations can alter cochlear antioxidant capacity but do not ameliorate age-related sensorineural hearing loss in the CBA/J mouse.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. shasu@musc.edu
authors.forename: Su-Hua
authors.initials: SH
authors.lastname: Sha
authors.forename: Ariane
authors.initials: A
authors.lastname: Kanicki
authors.forename: Karin
authors.initials: K
authors.lastname: Halsey
authors.forename: Kimberly Anne
authors.initials: KA
authors.lastname: Wearne
authors.forename: Jochen
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D008137:Longitudinal Studies; D051379:Mice; D008808:Mice, Inbred CBA; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D011304:Presbycusis / Q000178:diet therapy* / Q000517:prevention & control*
chemical_list: D000975:Antioxidants