title: Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.
abstract: The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-γ-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.
authors.affiliation: General Dermatology, Medical University of Graz, Graz, Austria. juergen.becker@medunigraz.at
authors.forename: Jürgen C
authors.initials: JC
authors.lastname: Becker
authors.forename: David
authors.initials: D
authors.lastname: Schrama
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D010088:Oxidoreductases / Q000276:immunology*; D050862:Oxidoreductases Acting on Sulfur Group Donors; D014820:Vitiligo / Q000276:immunology*
chemical_list: D010088:Oxidoreductases; C064056:tyrosinase-related protein-1; C483811:Ifi30 protein, mouse; D050862:Oxidoreductases Acting on Sulfur Group Donors