title: Role of NYGGF4 in insulin resistance.
abstract: Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin. A major factor in the development of insulin resistance syndrome is obesity. NYGGF4 is a novel gene that is abundantly expressed in the adipose tissue of obese subjects. NYGGF4 induced the secretion of FFAs and TNF-α and caused mitochondrial dysfunction, which may cause insulin resistance. This review will summarize the effect of NYGGF4 on the adipogenesis, glucose uptake and mitochondrial dysfunction in vitro, and the possible mechanism and signal pathway of NYGGF4 for insulin resistance.
authors.affiliation: Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, 625014, Sichuan, People's Republic of China. chenxlh@hotmail.com
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Chen
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Huang
authors.forename: Daiwen
authors.initials: D
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Jia
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Mao
authors.forename: Xiuqun
authors.initials: X
authors.lastname: Wu
mesh_terms: D050156:Adipogenesis; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D005947:Glucose