title: Association of bone mineral density, parameters of bone turnover, and body composition in patients with chronic obstructive pulmonary disease.
abstract: Patients with chronic obstructive pulmonary disease (COPD) often develop osteoporosis. Many hormones regulate bone metabolism and body composition, and some of them are affected in COPD patients vs controls. In 46 COPD patients, we measured hip neck, total hip, lumbar spine, and whole-body T-score with dual-energy X-ray absorptiometry, parameters of body composition (body mass index [BMI], fat mass index [FMI], and fat-free mass index [FFMI]), and adiponectin, leptin, parathormone, osteocalcin, calcitonin, and insulin-like growth factor I (IGF-I) serum levels and correlated them with COPD stage. Our results suggest that total hip bone mineral density (BMD) is affected by FFMI and COPD stage; lumbar spine BMD is affected by FMI and COPD stage; and whole-body BMD is affected by BMI, COPD stage, and leptin. Adiponectin, parathormone, osteocalcin, calcitonin, and IGF-I levels were not significantly correlated to BMD at any of the measured sites. Our findings are in agreement with the current literature in that a decline in lung function is correlated to a decline in BMD.
authors.affiliation: Department of Diagnostic Radiology, School of Health Sciences, University of Thessaly, University Hospital of Larissa, Biopolis, Larissa, Greece.
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Fountoulis
authors.forename: Markos
authors.initials: M
authors.lastname: Minas
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
authors.forename: Ioannis V
authors.initials: IV
authors.lastname: Fezoulidis
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Gourgoulianis
authors.forename: Marianna
authors.initials: M
authors.lastname: Vlychou
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology*; D012044:Regression Analysis
chemical_list: D015415:Biomarkers