title: Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats.
abstract: This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000 mg kg⁻¹ doses of Al₂O₃ -30 and -40 nm and bulk Al₂O₃ in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al₂O₃ nanomaterials at 2000 mg kg⁻¹.
authors.affiliation: Toxicology Unit, Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh, India.
authors.forename: P V
authors.initials: PV
authors.lastname: Prabhakar
authors.forename: Utkarsh A
authors.initials: UA
authors.lastname: Reddy
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Balasubramanyam
authors.forename: M F
authors.initials: MF
authors.lastname: Rahman
authors.forename: S
authors.initials: S
authors.lastname: Indu Kumari
authors.forename: Sachin B
authors.initials: SB
authors.lastname: Agawane
authors.forename: U S N
authors.initials: US
authors.lastname: Murty
authors.forename: Paramjit
authors.initials: P
authors.lastname: Grover
authors.forename: Mohammed
authors.initials: M
authors.lastname: Mahboob
mesh_terms: D000284:Administration, Oral; D000537:Aluminum Oxide / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D053768:Metal Nanoparticles / Q000633:toxicity*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D036103:Nanotechnology; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D008315:Malondialdehyde; D010088:Oxidoreductases; D005978:Glutathione; D000537:Aluminum Oxide