title: Reduced prefrontal hemodynamic response in children with ADHD during the Go/NoGo task:  a NIRS study.
abstract: The current study examined the hemodynamic response during the Go/NoGo task in children with/without attention deficit/hyperactivity disorder (ADHD). Using near-infrared spectroscopy, oxy-Hb and deoxy-Hb concentration changes in the frontal areas were compared during the conditions with/without inhibitory demand. Compared with typically developing children, children with ADHD showed significantly reduced activation during the conditions with inhibitory demand (NoGo-condition) in the frontal areas. However, no significant differences in activation during the conditions without inhibitory demand (Go-condition) were found between the two groups. The current findings revealed that children with ADHD exhibit an altered hemodynamic response specifically during response inhibition, but not during response execution, and suggested the clinical usefulness of near-infrared spectroscopy for the evaluation of response inhibition deficits in children with ADHD.
authors.affiliation: Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan. yu.inoue@shimada-ryoiku.or.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Kotoe
authors.initials: K
authors.lastname: Sakihara
authors.forename: Atsuko
authors.initials: A
authors.lastname: Gunji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ozawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimiya
authors.forename: Haruo
authors.initials: H
authors.lastname: Shinoda
authors.forename: Makiko
authors.initials: M
authors.lastname: Kaga
authors.forename: Masumi
authors.initials: M
authors.lastname: Inagaki
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000098:blood supply* / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared