title: Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives.
abstract: A simple and novel protocol for the efficient synthesis of a series of 8-carboxylnaphthyl functionalized pyrazolo[3,4-b]pyridine derivatives was developed through a one-pot, three-component reaction involving acenaphthylene-1,2-dione and 1H-pyrazol-5-amine in acetic acid medium. The reaction represents the first facile conversion of acenaphthenequinone to naphthoic acid via C-C bond cleavage without need for multi-step transformation.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hao
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhao
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C542126:1H-pyrazol-5-amine; C478081:1H-pyrazolo(3,4-b)pyridine; D000073:Acenaphthenes; D011720:Pyrazoles; D011725:Pyridines; C042553:acenaphthylene