title: The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection.
abstract: BACKGROUND
  Use of endoscopic submucosal dissection (ESD) for management of widespread superficial esophageal carcinomas may be complicated by the development of severe strictures, which may require serial treatment with endoscopic balloon dilatation (EBD).
  
  
  OBJECTIVE
  The goal of this study was to determine the efficacy of endoscopic triamcinolone injection (ETI) for the prevention of stricture formation after ESD.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Tertiary-care referral center.
  
  
  METHODS
  A total of 41 consecutive patients who had a semi-circumferential mucosal defect that arose after ESD for superficial esophageal squamous cell carcinomas were enrolled in this study.
  
  
  METHODS
  EBD and ETI.
  
  
  METHODS
  Incidence of stricture and frequency of required EBD.
  
  
  RESULTS
  ETI was performed in one group of patients (study group, n = 21) but not in the other (control group, n = 20). The incidence of stricture was significantly lower in the study group (19.0%) than in the control group (75.0%; P < .001). The number of required EBDs was also lower in the study group (mean, 1.7; range, 0-15) than in the control group (mean, 6.6; range 0-20). There were no side effects or complications associated with ETI.
  
  
  CONCLUSIONS
  Nonrandomized study design and small number of patients in a single endoscopic center.
  
  
  CONCLUSIONS
  This study suggests that ETI is safe and effective for the prevention of esophageal stricture in patients undergoing ESD for superficial esophageal squamous cell carcinomas.
authors.affiliation: Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Manabu
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Rintaro
authors.initials: R
authors.lastname: Narisawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery*; D004210:Dissection / Q000009:adverse effects*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D004947:Esophagus; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007267:Injections; D007413:Intestinal Mucosa / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone