title: Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes.
abstract: OBJECTIVE
  Adiponectin has anti-atherogenic properties and reduced serum adiponectin levels are associated with cardiovascular disease (CVD). In this study, we examined the relationship between CVD and adiponectin (ADIPOQ) gene G276T polymorphism that is associated with serum adiponectin level in a large cohort of type 2 diabetic patients.
  
  
  METHODS
  We enrolled 2637 Japanese type 2 diabetic subjects (males, 61.1%; age, 54.9±7.9 years old), determined their genotypes regarding ADIPOQ G276T polymorphisms, and evaluated the association between this polymorphism and the prevalence of CVD (myocardial infarction and/or cerebral infarction).
  
  
  RESULTS
  The prevalence of CVD tended to be higher as the number of G alleles increased [GG (9.5%), GT (6.8%), TT (5.6%), p value for trend=0.0059] and was significantly higher in the subjects with GG genotype compared to those with GT or TT genotype (9.5% vs. 6.6%, p=0.0060). Multiple logistic regression analyses revealed that the number of G alleles (Odds ratio (OR)=1.49 with 95%CI 1.09-2.05, p=0.0125) and GG genotype (OR=1.66 with 95%CI 1.13-2.43, p=0.0098) were significantly associated with CVD even after adjustment for conventional risk factors. Interestingly, the presence of obesity further and significantly increased the risk of CVD in the subjects with GG genotype (OR=1.67 with 95%CI 1.14-2.44, p=0.0090) but not in the subjects with TT or GT genotype (OR=1.17 with 95%CI 0.73-1.89, NS).
  
  
  CONCLUSIONS
  It is likely that the G allele of the ADIPOQ G276T polymorphism is a susceptibility allele for CVD in Japanese type 2 diabetic patients, especially when they accompany obesity.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. katakami@medone.med.osaka-u.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Katakami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Taka-aki
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Takahara
authors.forename: Norikazu
authors.initials: N
authors.lastname: Maeda
authors.forename: Ikki
authors.initials: I
authors.lastname: Shimizu
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Osonoi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Fukashi
authors.initials: F
authors.lastname: Ishibashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Imamura
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics*; D002544:Cerebral Infarction / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D009765:Obesity / Q000208:ethnology / Q000235:genetics; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin