title: Exposure to maternal overnutrition and a high-fat diet during early postnatal development increases susceptibility to renal and metabolic injury later in life.
abstract: Overnutrition during pre- and postnatal development both confer increased susceptibility to renal and metabolic risks later in life; however, whether they have an additive effect on the severity of renal and metabolic injury remains unknown. The present study tested the hypothesis that a combination of a pre- and postnatal diet high in fat/fructose would exacerbate renal and metabolic injury in male offspring later in life. Male offspring born to high fat/high-fructose-fed mothers and fed a high-fat/high-fructose diet postnatally (HF-HF) had increased urine albumin excretion (450%), glomerulosclerosis (190%), and tubulointerstitial fibrosis (101%) compared with offspring born to mothers fed a standard diet and fed a standard diet postnatally (NF-NF). No changes in blood pressure or glomerular filtration were observed between any of the treatment groups. The HF-HF offspring weighed ∼23% more than offspring born to mothers fed a high-fat/high-fructose diet and fed a normal diet postnatally (HF-NF), as well as offspring born to mothers fed a standard diet regardless of their postnatal diet. The HF-HF rats also had increased (and more variable) blood glucose levels over 12 wk of being fed a high-fat/high-fructose diet. A combination of exposure to a high-fat/high-fructose diet in utero and postnatally increased plasma insulin levels by 140% compared with NF-NF offspring. Our data suggest that the combined exposure to overnutrition during fetal development and early postnatal development potentiate the susceptibility to renal and metabolic disturbances later in life.
authors.affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, USA.
authors.forename: Colette M
authors.initials: CM
authors.lastname: Jackson
authors.forename: Barbara T
authors.initials: BT
authors.lastname: Alexander
authors.forename: Lauren
authors.initials: L
authors.lastname: Roach
authors.forename: Deani
authors.initials: D
authors.lastname: Haggerty
authors.forename: David C
authors.initials: DC
authors.lastname: Marbury
authors.forename: Zachary M
authors.initials: ZM
authors.lastname: Hutchens
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Flynn
authors.forename: Christine
authors.initials: C
authors.lastname: Maric-Bilkan
mesh_terms: D000375:Aging; D000419:Albuminuria; D000818:Animals; D001786:Blood Glucose; D001823:Body Composition; D001835:Body Weight; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats