title: Tandem arrays of TEMPO and nitronyl nitroxide radicals with designed arrangements on DNA.
abstract: Herein we describe one-dimensional electron-spin arrays consisting of two different organic radicals with the designed arrangement based on the DNA sequence. Two mismatch-binding ligands carrying 2,2,6,6-tetramethylpiperidine N-oxide (TEMPO) and nitronyl nitroxide selectively bind to the predetermined sites on double stranded DNA. By using the two mismatch-binding ligands carrying the organic radicals as the glue for DNA, electron-spin assembly could be successfully synchronized with the hybridization. Periodically and tandemly arranged, two kinds of organic radical molecules at designed positions might be useful for an approach to build up scalable qubits of electron-spin-based quantum computing. The approach using DNA nanostructures as a scaffold to assembly functional small molecules can afford one of the promising ways for the future application of DNA nanostructures and nanotechnology.
authors.affiliation: Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Atsumi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Maekawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shiomi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Takeji
authors.initials: T
authors.lastname: Takui
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakatani
mesh_terms: D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry
chemical_list: D003497:Cyclic N-Oxides; D009589:Nitrogen Oxides; D004247:DNA; C039900:nitroxyl; C003959:TEMPO