title: Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat cortical membranes.
abstract: Treatment for 1, 3 or 10 days with sibutramine hydrochloride (3 mg/kg), desi pramine (10 mg/kg), amitriptyline (10 mg/kg) or pargyline (10 mg/kg) did not effect the number or affinity of α(1)-adrenoceptors as determined by [(3)H]-prazosin binding to rat cerebral cortical membranes. Similarly, neither single, nor repeated (five times over 10 days) electroconvulsive shocks, given under halothane anaesthesia had any effect on the parameters of [(3)H]-prazosin binding. These data suggest that the clinical actions of these treatments are unlikely to involve changes in α(1)-adrenoceptor function.
authors.affiliation: Research Department, The Boots Company plc, Nottingham NG2 3AA, UK.
authors.forename: K F
authors.initials: KF
authors.lastname: Martin
authors.forename: I
authors.initials: I
authors.lastname: Phillips
authors.forename: D J
authors.initials: DJ
authors.lastname: Heal
authors.forename: W R
authors.initials: WR
authors.lastname: Buckett