title: [Effects of cytokine-like polypeptide EMAP II and flutamide on the testosterone-stimulated prostate of castrated rats].
abstract: The effects of separate and combined administration of cytokine-like polypeptide EMAP II and flutamide, a nonsteroid antiandrogen, on morphology and function of the accessory sexual glands in castrated rats stimulated with testosterone propionate were studied. We found antiangiogenic, procoagulating and proapoptotic effects of EMAP II in the ventral prostate. Combined administration of the preparations enhanced their antiprostatic effects, which were manifested in inhibition of the androgen-dependent processes in prostate tissues, changes in proliferation and apoptosis, DNA, RNA and protein contents. We conclude that combined administration of EMAP II and flutamide can be used for development of new therapeutic modalities in prostate cancer.
authors.forename: O H
authors.initials: OH
authors.lastname: Reznikov
authors.forename: L V
authors.initials: LV
authors.lastname: Chaĭkovs'ka
authors.forename: L I
authors.initials: LI
authors.lastname: Poliakova
authors.forename: O V
authors.initials: OV
authors.lastname: Sachyns'ka
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000494:pharmacology*; D004357:Drug Synergism; D005485:Flutamide / Q000494:pharmacology*; D008297:Male; D009363:Neoplasm Proteins / Q000494:pharmacology*; D009919:Orchiectomy; D011467:Prostate / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000517:prevention & control; D016601:RNA-Binding Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D043343:Testosterone Propionate / Q000494:pharmacology*
chemical_list: D000726:Androgen Antagonists; D020533:Angiogenesis Inhibitors; D016207:Cytokines; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; C077219:small inducible cytokine subfamily E, member 1; D005485:Flutamide; D043343:Testosterone Propionate