title: [Effect of latent asymptomatic toxoplasmosis on glucose metabolism in brain of mice].
abstract: OBJECTIVE
  To explore the effect of latent asymptomatic Toxoplasma gondii infection on glucose metabolism in brain of mice.
  
  
  METHODS
  Twenty mice were randomly divided into two groups: a Toxoplasma infected group and normal control group. The mice in the Toxoplasma infected group were inoculated with 0.3 ml of brain suspension in saline containing ten Toxoplasma gondii tissue cysts, avirulent Toxoplasma gondii Prugniaud (PRU, a Type II strain). The mice in the control group received 0.3 ml of saline orally. Six monthes after the infection, the glucose metabolism changes in the mouse brain were evaluated by MicroPET, then all the mice were sacrificed and the brain tissues were observed histopathologically.
  
  
  RESULTS
  Compared with the normal controls, the infected mice demonstrated profound and widespread brain pathology, and MicroPET indicated a significant glucose metabolism reduction in the brain of asymptomatic Toxoplasma gondii infected mice.
  
  
  CONCLUSIONS
  Chronic Toxoplasma gondii infection maybe results in the glucose metabolism reduction in the brain of mice.
authors.affiliation: Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Wuxi 214064, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Zhou
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Huang
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Tao
authors.forename: Hui-Xin
authors.initials: HX
authors.lastname: Yu
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000378:metabolism* / Q000469:parasitology
chemical_list: D005947:Glucose