title: Leukemia relapse after allogeneic bone marrow transplantation: how does chronic graft-versus-host disease influence the pattern and onset of relapse?
abstract: We describe a pattern of relapse in 601 patients who received an allogeneic hematopoietic stem cell transplant at our institution for acute or chronic leukemia and myelodysplasia over a period of 18 years. We show a correlation between chronic graft-versus-host disease and extramedullary relapse, suggesting that the expected graft versus leukemia effect in patients with chronic graft-versus-host disease may preferentially maintain marrow remission without preventing relapse in extramedullary sites.
authors.forename: A
authors.initials: A
authors.lastname: Al Beihany
authors.forename: F
authors.initials: F
authors.lastname: Al Mohareb
authors.forename: H
authors.initials: H
authors.lastname: Al Zahrani
authors.forename: Fahad
authors.initials: F
authors.lastname: Alsharif
authors.forename: Naeem
authors.initials: N
authors.lastname: Chaudhri
authors.forename: Said Yousuf
authors.initials: SY
authors.lastname: Mohamed
authors.forename: Walid
authors.initials: W
authors.lastname: Rasheed
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Aljurf
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D020544:Graft vs Leukemia Effect; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D012529:Saudi Arabia; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult