title: Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF.
abstract: Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors. An 84-year-old woman experienced swelling and pain in the shoulder for 1 month. Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection. A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically. Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Ishii
authors.forename: Akio
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsuda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Harimaya
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Iwamoto
mesh_terms: D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000473:pathology*; D007890:Leiomyosarcoma / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D007964:Leukocytosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D011859:Radiography
chemical_list: D016179:Granulocyte Colony-Stimulating Factor