title: [Eosinophilic pleural effusion related to taking valproic acid].
abstract: Eosinophilic pleural effusions have multiple aetiologies. We report on the case of a 40-year-old man who experienced an eosinophilic pleural effusion with blood hypereosinophilia that occurred nine weeks after a treatment with valproic acid was introduced. Usual aetiologies of eosinophilic pleural effusion were excluded. Once valproic acid was discontinued, both pleural effusion and blood eosinophilia decreased rapidly. The persistence of a residual pleural effusion required the introduction of oral corticosteroids, which resulted in the effusion disappearing completely and rapidly. Valproic acid is a rare cause of eosinophilic pleural effusion. The effusion usually regresses when treatment is discontinued but short-term oral corticotherapy may be necessary in order to heal the patient.
authors.affiliation: Service de pneumologie, hôpital Cochin, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bally
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Kraoua
authors.forename: R
authors.initials: R
authors.lastname: Kanaan
authors.forename: J
authors.initials: J
authors.lastname: Lacronique
authors.forename: D
authors.initials: D
authors.lastname: Dusser
authors.forename: P-R
authors.initials: PR
authors.lastname: Burgel
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects; D001772:Blood Cell Count; D004802:Eosinophilia / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D008297:Male; D010996:Pleural Effusion / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D018692:Antimanic Agents; D014635:Valproic Acid