title: Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009).
abstract: The aim of this study was to estimate influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza among hospitalized patients. A case-control investigation was based on the prospective surveillance of influenza-like illness (ILI) during five flu seasons. We compared influenza-positive cases and influenza-negative controls. Unadjusted overall IVE was 62% (95% confidence interval 24% to 81%). We found that IVE was lower during the 2004-05 flu season (11%; 95% CI -232% to 76%) when the vaccine and circulating viruses were mismatched. Expansion of the study to other hospitals could provide IVE estimates earlier in the season, for different age groups and emerging virus strains.
authors.affiliation: Université de Lyon, Université de Lyon 1, CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France.
authors.forename: Sélilah
authors.initials: S
authors.lastname: Amour
authors.forename: Nicolas
authors.initials: N
authors.lastname: Voirin
authors.forename: Corinne
authors.initials: C
authors.lastname: Regis
authors.forename: Maude
authors.initials: M
authors.lastname: Bouscambert-Duchamp
authors.forename: Brigitte
authors.initials: B
authors.lastname: Comte
authors.forename: Brigitte
authors.initials: B
authors.lastname: Coppéré
authors.forename: Silene
authors.initials: S
authors.lastname: Pires-Cronenberger
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanhems
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005602:France; D006785:Hospitals, University; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000175:diagnosis / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007252:Influenza Vaccines