title: Catalytic asymmetric construction of tetrasubstituted carbon stereocenters by conjugate addition of dialkyl phosphine oxides to β,β-disubstituted α,β-unsaturated carbonyl compounds.
abstract: The catalytic asymmetric phospha-Michael reaction of dialkyl phosphine oxides with β,β-disubstituted α,β-unsaturated carbonyl compounds was achieved. The products bearing tetrasubstituted carbon stereocenters were obtained in high yields with excellent enantioselectivities (up to >99% ee).
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, PR China.
authors.forename: Depeng
authors.initials: D
authors.lastname: Zhao
authors.forename: Lijuan
authors.initials: L
authors.lastname: Mao
authors.forename: Linqing
authors.initials: L
authors.lastname: Wang
authors.forename: Dongxu
authors.initials: D
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D002244:Carbon; D002384:Catalysis; D005663:Furans / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry
chemical_list: D005663:Furans; D010087:Oxides; D010720:Phosphines; D011725:Pyridines; D011758:Pyrroles; D012997:Solvents; D014050:Toluene; C018674:tetrahydrofuran; D002244:Carbon; C044646:phosphine; C023666:pyridine