title: Use of a new ziprasidone-selective electrode in mixed solvents and its application in the analysis of pharmaceuticals and biological fluids.
abstract: The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2:3 (v/v) methanol/water medium from a ziprasidone concentration of 3 × 10(-6) M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30100 Murcia, Spain. msgarcia@um.es
authors.forename: M Soledad
authors.initials: MS
authors.lastname: García
authors.forename: Joaquín A
authors.initials: JA
authors.lastname: Ortuño
authors.forename: María
authors.initials: M
authors.lastname: Cuartero
authors.forename: Mustafa Salem
authors.initials: MS
authors.lastname: Abuherba
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D002138:Calibration; D004566:Electrodes; D006801:Humans; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010879:Piperazines / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D010879:Piperazines; D012997:Solvents; D013844:Thiazoles; C092292:ziprasidone