title: Caveolin-1 as a potential high-risk prostate cancer biomarker.
abstract: Current diagnostic techniques of prostate cancer cannot efficiently distinguish             the latent and low-risk forms from the high-risk significant forms of prostate             cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in             cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved             in metastatic processes. It has also been shown that Cav-1 expression is induced             under stress conditions, such as oxidative stress. The present study focused on             the determination of prognostic markers of aggressive (high-grade) forms of prostate             cancer. We determined serum Cav-1 and serum markers of antioxidant activity-glutathione             (GSH), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity             (TEAC), ferric-reducing antioxidant power (FRAP), N,N-dimethyl-1,4-diaminobenzene             (DMPD), free radicals method (FRK) and blue chromium peroxide (Cro) in 97 serum             samples (82 prostate cancer patients and 15 controls). We found insignificant             differences in Cav-1 between the sera of patients and controls (5.69 in the cancer             group vs. 5.42 ng/ml in the control group). However, we found a significant (p<0.004)             2.8-fold elevation of Cav-1 in high tumour stages (TNM T4) compared to lower stages             and a significant positive association with histological grading (r=0.29, p=0.028).             We also found that in patients with high serum Cav-1 the antioxidant capacity             of the body is reduced. These findings indicate that Cav-1 may be an interesting             tool for the prediction of disease burden.
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, and Department of Urology, St. Anne's University Hospital Brno, CZ-625 00 Brno, Czech Republic.
authors.forename: Jaromir
authors.initials: J
authors.lastname: Gumulec
authors.forename: Jiri
authors.initials: J
authors.lastname: Sochor
authors.forename: Marian
authors.initials: M
authors.lastname: Hlavna
authors.forename: Marketa
authors.initials: M
authors.lastname: Sztalmachova
authors.forename: Sona
authors.initials: S
authors.lastname: Krizkova
authors.forename: Petr
authors.initials: P
authors.lastname: Babula
authors.forename: Roman
authors.initials: R
authors.lastname: Hrabec
authors.forename: Arne
authors.initials: A
authors.lastname: Rovny
authors.forename: Vojtech
authors.initials: V
authors.lastname: Adam
authors.forename: Tomas
authors.initials: T
authors.lastname: Eckschlager
authors.forename: Rene
authors.initials: R
authors.lastname: Kizek
authors.forename: Michal
authors.initials: M
authors.lastname: Masarik
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D001713:Biphenyl Compounds / Q000097:blood; D051242:Caveolin 1 / Q000097:blood*; D002839:Chromans / Q000097:blood / Q000378:metabolism; D017608:Chromium Compounds / Q000097:blood; D005609:Free Radicals / Q000097:blood; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010545:Peroxides / Q000097:blood; D010851:Picrates / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood*
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D001713:Biphenyl Compounds; D051242:Caveolin 1; D002839:Chromans; D017608:Chromium Compounds; D005609:Free Radicals; D010545:Peroxides; D010851:Picrates; C544191:chromium peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D005978:Glutathione; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid