title: EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report.
abstract: Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.
authors.affiliation: Department of Pathology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. u.flucke@pathol.umcn.nl
authors.forename: Uta
authors.initials: U
authors.lastname: Flucke
authors.forename: Thomas
authors.initials: T
authors.lastname: Mentzel
authors.forename: Marian A
authors.initials: MA
authors.lastname: Verdijk
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Slootweg
authors.forename: David H
authors.initials: DH
authors.lastname: Creytens
authors.forename: Albert J H
authors.initials: AJ
authors.lastname: Suurmeijer
authors.forename: Bastiaan B J
authors.initials: BB
authors.lastname: Tops
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000235:genetics* / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D010386:Pelvic Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C560860:EWSR1-ATF1 fusion protein, human; D015514:Oncogene Proteins, Fusion