title: Early prediction of nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation.
abstract: OBJECTIVE
  To predict early nasal continuous positive airway pressure failure within the first 2 h after birth in preterm infants.
  
  
  METHODS
  Patient and respiratory support variables significantly associated with continuous positive airway pressure failure in the first 72 h after birth were identified in a cohort of preterm infants <30 weeks gestation. Using multivariable logistic regression analysis, risk estimates for early nasal continuous positive airway pressure failure were calculated.
  
  
  RESULTS
  From 182 infants included, 62(34%) failed early nasal continuous positive airway pressure. Birth weight ≤800 g, male gender and a fraction of inspired oxygen >0.25 at 1 and 2 h of age were significantly associated with early nasal continuous positive airway pressure failure. Combining these variables in a logistic regression model provided a minimal risk estimate for failure of 0.04[0.01-0.23] (female >800 g, FiO(2) ≤ 0.25 at 1, and 2 h) and maximal estimate of 0.92[0.44-0.99] (male ≤800 g, FiO(2) > 0.25 at 1 and 2 h).
  
  
  CONCLUSIONS
  Combining gender, birth weight and the fraction of inspired oxygen at 1 and 2 h of age allows for a better and more individualized prediction of early nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation.
authors.affiliation: Department of Neonatology Emma Children's Hospital AMC, Amsterdam, The Netherlands. a.p.dejaegere@amc.nl
authors.forename: Anne P
authors.initials: AP
authors.lastname: De Jaegere
authors.forename: Johanna H
authors.initials: JH
authors.lastname: van der Lee
authors.forename: Caroline
authors.initials: C
authors.lastname: Canté
authors.forename: Anton H
authors.initials: AH
authors.lastname: van Kaam
mesh_terms: D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure