title: [The composition of blood lipoproteins of donors 2 hours later after single atorvastatin intake].
abstract: The distribution of single intake atorvastatin in the content of very low, low and high density lipoproteins extracted from blood plasma of healthy volunteers by means of ultracentrifugal separation was investigated. The impact of atorvastatin on the composition of lipoprotein complexes was assessed. It is demonstrated that atorvastatin and its active derivatives transport mainly in the composition of high density lipoproteins. The distribution of atorvastatin and its biologically active metabolites has gender differences. It is established that in males atorvastatin increases the content of triacylglycerides of low density lipoproteins and cholesterol of high density lipoproteins in females.
authors.forename: S V
authors.initials: SV
authors.lastname: Buianova
authors.forename: S S
authors.initials: SS
authors.lastname: Osochuk
authors.forename: G D
authors.initials: GD
authors.lastname: Korobov
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000069059:Atorvastatin / Q000031:analogs & derivatives; D001693:Biological Transport, Active / Q000187:drug effects; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011758:Pyrroles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012727:Sex Characteristics; D013997:Time Factors
chemical_list: C518963:2-hydroxyatorvastatin; D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011758:Pyrroles; C518964:4-hydroxyatorvastatin; D000069059:Atorvastatin