title: Interleukin-4 -590T/C polymorphism influences the susceptibility to nonsmall cell lung cancer.
abstract: Lung cancer is the leading cause of cancer mortality worldwide. Nonsmall cell lung cancer (NSCLC) accounts for most of these cases. Interleukin 4 (IL-4) is a typical pleiotropic T helper 2 cytokine and plays crucial roles in tumor immunology. IL-4 gene -590T/C polymorphism has been shown to be associated with different autoimmune diseases and cancers. The present study evaluated the correlation between this polymorphism and the susceptibility to NSCLC in the Chinese population. The IL-4 variant -590T/C was detected by polymerase chain reaction-restriction fragment length polymorphism in 1072 NSCLC cases and 1126 age-matched healthy controls. Data were analyzed using the Chi-square test. Results showed that frequencies of IL-4 -590 TC, CC genotype, and -590 C allele were significantly lower in patients with NSCLC than in healthy controls (odds ratio [OR]=0.77, 95% confidence interval [CI] 0.64-0.93, p=0.006; OR=0.54, 95% CI 0.38-0.76, p=0.0004; and OR=0.72, 95% CI 0.62-0.83, p=1.1 × 10(-5), respectively). Our data suggest that the -590T/C polymorphism of the IL-4 gene is associated with a decreased susceptibility to NSCLC.
authors.affiliation: Department of Lung Cancer, Affiliated Hospital of Academy of Military Medical Sciences of PLA, Fengtai, Beijing, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shi
authors.forename: Guanzhen
authors.initials: G
authors.lastname: Yu
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Li
authors.forename: Wanfeng
authors.initials: W
authors.lastname: Guo
authors.forename: Chuanhao
authors.initials: C
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Hongjun
authors.initials: H
authors.lastname: Gao
authors.forename: Haifeng
authors.initials: H
authors.lastname: Qin
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D044466:Asian People / Q000235:genetics; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015847:Interleukin-4; D004247:DNA