title: Biliary papillomatosis in three Caucasian patients in a Western centre.
abstract: BACKGROUND
  Biliary papillomatosis (BP) is a rare condition with a strong potential for malignant transformation and cases from Western centres are sparse.(1) We discuss the presentation, investigation and management of this condition in three Caucasian patients and present a review of the existing literature on BP.
  
  
  METHODS
  The case notes of three Caucasian patients with BP who presented to our tertiary referral centre were reviewed. Their case histories, investigations and managements are presented. A search of MEDLINE, PubMed and Cochrane databases was performed to review relevant literature around BP.
  
  
  CONCLUSIONS
  BP is a rare condition characterised by multiple papillary adenomas involving the biliary tree which lead to recurrent attacks of cholangitis. It is a low-grade neoplasm with high malignant potential and should be regarded as a pre-malignant lesion.
authors.affiliation: Department of Hepatobiliary and Transplant Surgery, St James's University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom. alanwhite@doctors.org.uk
authors.forename: A D
authors.initials: AD
authors.lastname: White
authors.forename: A L
authors.initials: AL
authors.lastname: Young
authors.forename: C
authors.initials: C
authors.lastname: Verbeke
authors.forename: R
authors.initials: R
authors.lastname: Brannan
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: K R
authors.initials: KR
authors.lastname: Prasad
mesh_terms: D001661:Biliary Tract Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D001707:Biopsy, Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D002761:Cholangitis / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D016031:Liver Transplantation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D035583:Rare Diseases; D018570:Risk Assessment; D012494:Sampling Studies; D015996:Survival Rate; D016896:Treatment Outcome; D006113:United Kingdom