title: Five genome sequences of subspecies B1 human adenoviruses associated with acute respiratory disease.
abstract: Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV-7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.
authors.affiliation: School of Systems Biology, George Mason University, Manassas, Virginia 20110, USA.
authors.forename: Shoaleh
authors.initials: S
authors.lastname: Dehghan
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Liu
authors.forename: Jason
authors.initials: J
authors.lastname: Seto
authors.forename: Sarah F
authors.initials: SF
authors.lastname: Torres
authors.forename: Nolan R
authors.initials: NR
authors.lastname: Hudson
authors.forename: Adriana E
authors.initials: AE
authors.lastname: Kajon
authors.forename: David
authors.initials: D
authors.lastname: Metzgar
authors.forename: David W
authors.initials: DW
authors.lastname: Dyer
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
mesh_terms: D000208:Acute Disease; D000258:Adenovirus Infections, Human / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D001483:Base Sequence; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D012141:Respiratory Tract Infections / Q000821:virology*