title: Removal of cadmium by combining deferasirox and desferrioxamine chelators in rats.
abstract: An investigation was conducted to evaluate the ability of two chelators, deferasirox and desferrioxamine (DFO), in removing cadmium from biological system. The potential efficiency of those chelators were investigated after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, abnormalities were observed in clinical signs after cadmium administration, such as yellowish discoloration of hair, flaccid and hypotonic muscles, irritability, weakness and loss of weight. The hypothesis that the two chelators might be more efficient as combined therapy than single therapy in removing metal ions from the body was considered. In this way, two known chelators, deferasirox and DFO were chosen and tested in the acute rat model. The chelation therapy results show that deferasirox and DFO are able (?)to remove cadmium ions from the body, while iron concentration returned to the normal level and symptoms are decreased.
authors.affiliation: Department of Chemistry, Islamic Azad University, Kerman Branch, Kerman, Iran. fatemijam@yahoo.com
authors.forename: S Jamilaldine
authors.initials: SJ
authors.lastname: Fatemi
authors.forename: Amir Shokooh
authors.initials: AS
authors.lastname: Saljooghi
authors.forename: Faezeh Dahooee
authors.initials: FD
authors.lastname: Balooch
authors.forename: Marzieh
authors.initials: M
authors.lastname: Iranmanesh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Golbafan
mesh_terms: D000818:Animals; D001565:Benzoates / Q000493:pharmacokinetics / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity; D002614:Chelating Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D015913:Chelation Therapy / Q000379:methods*; D000077588:Deferasirox; D003676:Deferoxamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D007501:Iron; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014230:Triazoles / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D001565:Benzoates; D002614:Chelating Agents; D014230:Triazoles; D002104:Cadmium; D007501:Iron; D003676:Deferoxamine; D000077588:Deferasirox