title: Case of adenomatid odontogenic tumor during pregnancy.
abstract: Adenomatoid odontogenic tumor (AOT) is a relatively rare benign tumor, accounting for 2% to 7% of odontogenic tumors. AOT is generally found in the incisor region of the maxilla of young women. It is often misdiagnosed as a dentigerous cyst.   We report a case of AOT during pregnancy. The patient was a 21-year-old Philippine woman who complained of a swelling in the right maxillary gingival; the swelling rapidly enlarged during pregnancy. We enucleated the tumor and the impacted canine, with the patient under general anesthesia. Histological examination revealed a pseudoglandular structure with odontogenic appearance. On the basis of these findings and the World health organization (WHO) classification, we diagnosed the tumor as an adenomatoid odontogenic tumor. The tumor cells were identified by an immunohistochemically positive reaction for Bcl-2 and estrogen receptor. The MIB-1 labeling index was less than 1%. There has been no sign of recurrence as of 1.5 years after the operation.
authors.affiliation: Department of Oral Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. rsekiya@tokai-u.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Sekiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Kazumi
authors.initials: K
authors.lastname: Izawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kaneko
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsukinoki
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007180:Incisor; D008441:Maxillary Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009808:Odontogenic Tumors / Q000145:classification / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D011247:Pregnancy; D011248:Pregnancy Complications; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D016896:Treatment Outcome; D014944:World Health Organization; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen