title: Robust antimicrobial compounds and polymers derived from natural resin acids.
abstract: We report novel robust resin acid-derived antimicrobial agents that exhibit excellent antimicrobial activities against a broad spectrum of bacteria (6 Gram-positive and 7 Gram-negative) with selective lysis of microbial membranes over mammalian membranes. Our results indicate that hydrophobicity and unique structures of resin acids can be determining factors in dictating the antimicrobial activity.
authors.affiliation: Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing 210042, China.
authors.forename: Jifu
authors.initials: J
authors.lastname: Wang
authors.forename: Yung Pin
authors.initials: YP
authors.lastname: Chen
authors.forename: Kejian
authors.initials: K
authors.lastname: Yao
authors.forename: Perry A
authors.initials: PA
authors.lastname: Wilbon
authors.forename: Wujie
authors.initials: W
authors.lastname: Zhang
authors.forename: Lixia
authors.initials: L
authors.lastname: Ren
authors.forename: Juhua
authors.initials: J
authors.lastname: Zhou
authors.forename: Mitzi
authors.initials: M
authors.lastname: Nagarkatti
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Wang
authors.forename: Fuxiang
authors.initials: F
authors.lastname: Chu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: He
authors.forename: Alan W
authors.initials: AW
authors.lastname: Decho
authors.forename: Chuanbing
authors.initials: C
authors.lastname: Tang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D006461:Hemolysis; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D012116:Resins, Plant / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D012116:Resins, Plant