title: Multislice ¹H MRSI of the human brain at 7 T using dynamic B₀ and B₁ shimming.
abstract: Proton MR spectroscopic imaging of the human brain at ultra-high field (≥7 T) is challenging due to increased radio frequency power deposition, increased magnetic field B(0) inhomogeneity, and increased radio frequency magnetic field inhomogeneity. In addition, especially for multislice sequences, these effects directly inhibit the potential gains of higher magnetic field and can even cause a reduction in data quality. However, recent developments in dynamic B(0) magnetic field shimming and dynamic multitransmit radio frequency control allow for new acquisition strategies. Therefore, in this work, slice-by-slice B(0) and B(1) shimming was developed to optimize both B(0) magnetic field homogeneity and nutation angle over a large portion of the brain. Together with a low-power water and lipid suppression sequence and pulse-acquire spectroscopic imaging, a multislice MR spectroscopic imaging sequence is shown to be feasible at 7 T. This now allows for multislice metabolic imaging of the human brain with high sensitivity and high chemical shift resolution at ultra-high field.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. v.o.boer@umcutrecht.nl
authors.forename: Vincent O
authors.initials: VO
authors.lastname: Boer
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
authors.forename: Christoph
authors.initials: C
authors.lastname: Juchem
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.forename: Robin A
authors.initials: RA
authors.lastname: de Graaf
mesh_terms: D000465:Algorithms; D001923:Brain Chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D011522:Protons; D012680:Sensitivity and Specificity
chemical_list: D011522:Protons