title: Drugs of the future for Peyronie's disease.
abstract: With the increasing awareness of Peyronie's disease (PD), the interest in new concept medications to treat the disorder is escalating. Profibrogenic factors such as transforming growth factor (TGF)-beta1, endothelin (ET-1), connective tissue growth factor (CTGF), angiotensin (Ang) II and platelet derived growth factor (PDGF), all appear to be involved in the pathogenesis of PD. β-Thymosins, pirfenidone, nitric oxide (NO) donors, phosphodiesterase (PDE)-5 inhibitors, matrix metalloproteinases (MMPs)/anti-tissue inhibitor of metalloproteinases (TIMP)-1 reduce collagen synthesis, while decorin, follistatin, and Smad 7 exert antifibrotic effects; all have been proposed for the treatment of PD. Alternative and/or novel approaches for the treatment of PD are needed in part because of the recognized multifactorial etiology of this complex disorder. A comprehensive approach for translating available experimental information into clinically effective drug trials for the treatment of PD is needed. We propose a multi-faceted approach for drug development to generate novel drug products for the treatment of PD.
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
authors.forename: Serap
authors.initials: S
authors.lastname: Gur
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kadowitz
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D055513:Connective Tissue Growth Factor / Q000378:metabolism; D004195:Disease Models, Animal; D015195:Drug Design; D004358:Drug Therapy / Q000639:trends; D019332:Endothelin-1 / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000188:drug therapy*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014945:Wound Healing
chemical_list: D019332:Endothelin-1; D010982:Platelet-Derived Growth Factor; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D055513:Connective Tissue Growth Factor