title: Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy.
abstract: IL-10 is an immunomodulatory cytokine that is frequently upregulated in various types of cancer. The biological role of IL-10 in cancer is quite complex; however, the presence of IL-10 in advanced metastases and the positive correlation between serum IL-10 levels and progression of disease indicates a critical role of IL-10 in the tumor microenvironment. IL-10 has been shown to directly affect the function of antigen-presenting cells by inhibiting the expression of MHC and costimulatory molecules, which in turn induces immune suppression or tolerance. Additionally, IL-10 downregulates the expression of Th1 cytokines and induces T-regulatory responses. Taken together, a combination of IL-10 antagonism and immunostimulatory treatments such as cancer vaccines, Toll-like receptor agonists, Th1 cytokines, and chemokines would be a logical approach to enhance an antitumor immune response.
authors.affiliation: Department of Medical Oncology, Jefferson Medical College of Thomas Jefferson University, 1015 Walnut Street, Suite 1024 Curtis Building, Philadelphia, PA 19107, USA. takami.sato@jefferson.edu
authors.forename: Takami
authors.initials: T
authors.lastname: Sato
authors.forename: Mizue
authors.initials: M
authors.lastname: Terai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamura
authors.forename: Vitali
authors.initials: V
authors.lastname: Alexeev
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mastrangelo
authors.forename: Senthamil R
authors.initials: SR
authors.lastname: Selvan
mesh_terms: D000818:Animals; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy / Q000379:methods*; D016753:Interleukin-10 / Q000037:antagonists & inhibitors* / Q000276:immunology; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D059016:Tumor Microenvironment
chemical_list: D016753:Interleukin-10