title: SRY protein function in sex determination: thinking outside the box.
abstract: Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical functions of the non-HMG-box domains in sex determination, and present possible explanations for the puzzling diversity of these non-HMG-box domains.
authors.affiliation: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.forename: Peter
authors.initials: P
authors.lastname: Koopman
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006059:Gonadal Dysgenesis / Q000235:genetics; D024742:HMG-Box Domains; D006801:Humans; D008297:Male; D008322:Mammals; D009154:Mutation; D011485:Protein Binding; D055747:SOX Transcription Factors / Q000737:chemistry / Q000235:genetics*; D012730:Sex Chromosomes / Q000737:chemistry / Q000235:genetics*; D019849:Sex Determination Processes; D015533:Transcriptional Activation
chemical_list: D004268:DNA-Binding Proteins; D055747:SOX Transcription Factors; D004247:DNA