title: Systematic review and meta-analysis of antibiotic prophylaxis to prevent infections from chest drains in blunt and penetrating thoracic injuries.
abstract: BACKGROUND
  No consensus exists as to whether antibiotic prophylaxis in tube thoracostomy as primary treatment for traumatic chest injuries reduces the incidence of surgical-site and pleural cavity infections.
  
  
  METHODS
  A systematic literature search was performed according to PRISMA guidelines to identify randomized clinical trials on antibiotic prophylaxis in tube thoracostomy for traumatic chest injuries. Data were extracted by two reviewers using piloted forms. Mantel-Haenszel pooled odds ratios (ORs) were calculated with 95 per cent confidence intervals (c.i.).
  
  
  RESULTS
  Eleven articles were included, encompassing 1241 chest drains in 1234 patients. Most patients (84·7 per cent) were men, and a penetrating injury mechanism was most common (856, 69·4 per cent). A favourable effect of antibiotic prophylaxis on the incidence of pulmonary infection was found, with an OR for the overall infectious complication rate of 0·24 (95 per cent c.i. 0·12 to 0·49). Patients who received antibiotic prophylaxis had an almost three times lower risk of empyema than those who did not receive antibiotic treatment (OR 0·32, 0·17 to 0·61). A subgroup analysis in patients with penetrating chest injuries showed that antibiotic prophylaxis in these patients reduced the risk of infection after tube thoracostomy (OR 0·28, 0·14 to 0·57), whereas in a relatively small blunt trauma subgroup no effect of antibiotic prophylaxis after blunt thoracic injury was found.
  
  
  CONCLUSIONS
  Infectious complications are less likely to develop when antibiotic prophylaxis is administered to patients with thoracic injuries requiring chest drains after penetrating injury.
authors.affiliation: Department of Surgery-Traumatology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Bosman
authors.forename: M B
authors.initials: MB
authors.lastname: de Jong
authors.forename: J
authors.initials: J
authors.lastname: Debeij
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Broek
authors.forename: I B
authors.initials: IB
authors.lastname: Schipper
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D015505:Chest Tubes; D004322:Drainage / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013898:Thoracic Injuries / Q000601:surgery*; D013907:Thoracostomy / Q000295:instrumentation / Q000379:methods; D014949:Wounds, Nonpenetrating / Q000601:surgery*; D014950:Wounds, Penetrating / Q000601:surgery*