title: Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.
abstract: Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms.
authors.affiliation: Department of Radiology, Washington University School of Medicine, St Louis, MO 63108, USA.
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Vlassenko
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mintun
authors.forename: Chengjie
authors.initials: C
authors.lastname: Xiong
authors.forename: Yvette I
authors.initials: YI
authors.lastname: Sheline
authors.forename: Alison M
authors.initials: AM
authors.lastname: Goate
authors.forename: Tammie L S
authors.initials: TL
authors.lastname: Benzinger
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D000814:Aniline Compounds; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002250:Carbon Radioisotopes; D003071:Cognition; D042241:Early Diagnosis; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D013844:Thiazoles