title: Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin-ruthenium metalla-cubes.
abstract: Two cationic octanuclear metalla-cubes [Ru(8)(η(6)-C(6)H(5)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) and [Ru(8)(η(6)-p-iPrC(6)H(4)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD(50)=2-7J/cm(2)), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.
authors.affiliation: Institute of Pathology, University Hospital of Lausanne, CHUV-UNIL, Bugnon 25, CH-1011 Lausanne, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Schmitt
authors.forename: Nicolas P E
authors.initials: NP
authors.lastname: Barry
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat-Jeanneret
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002412:Cations; D045744:Cell Line, Tumor; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008027:Light; D008545:Melanoma / Q000188:drug therapy; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010777:Photochemistry / Q000379:methods; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D002412:Cations; D008670:Metals; D017319:Photosensitizing Agents; D011166:Porphyrins; D012428:Ruthenium