title: Elderly renal transplant recipients and renal dysfunction: a risk factor for hyperuricemia.
abstract: OBJECTIVE
  To date, limited data are currently available on posttransplant hyperuricemia in elderly renal transplant patients.
  
  
  METHODS
  We conducted a retrospective study on 120 renal transplant patients aged ≥ 60 years old who received a kidney with at least a minimum time of 1 year after transplant between 2008 and 2011 in Iran. Hyperuricemia was defined if serum uric acid was ≥ 416.36 μmol/L in men (7.0 mg/dL), and ≥ 356.88 μmol/L in women (6 mg/dL) that persisted for at least 2 consecutive tests. Moderate-to-severe hyperuricemia also was defined as a serum uric acid of ≥ 475.84 μmol/L (8.0 mg/dL) in both sexes.
  
  
  RESULTS
  The majority of cases were men (66%) and only 9% received their grafts from deceased donors. The rate of deceased kidney transplant was higher in normouricemic patients. The prevalence of late posttransplant hyperuricemia was 37.5% of patients (n=45). Moderate-to-severe hyperuricemia was seen in 21 patients (17.5%). Although hyperuricemia was commonly observed in women than in men (43% in women vs 32% in men; P = .02), the rate of moderate-to-severe hyperuricemia was similar among both sexes (4.5% vs 4.3%; P = .9). Hyperuricemia frequently occurred in patients receiving kidney from a female donor (50% vs 29%; P = .005). In univariate analysis, a significant correlation was seen between serum uric acid and serum creatinine (r=0.5, P = .000). On multivariate regression, high serum creatinine was only a risk factor for posttransplant hyperuricemia in elderly kidney transplants (P = .000).
  
  
  CONCLUSIONS
  Posttransplant hyperuricemia was a quite common among elderly aged kidney recipients. It was correlated with renal allograft impairment.
authors.affiliation: Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Einollahi
authors.forename: Hoda
authors.initials: H
authors.lastname: Einollahi
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Rostami
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007492:Iran / Q000453:epidemiology; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D003404:Creatinine