title: Immunomodulatory mediators in platelet transfusion reactions.
abstract: Our appreciation of the roles that platelets play in vascular biology is constantly expanding. One of the major roles of platelets is in initiating and accelerating immune responses. Platelet transfusion may be associated with adverse inflammatory outcomes manifested as fever, discomfort, tachycardia, and respiratory issues. This may in part be due to immune mediators either expressed by activated platelets or released into the platelet media during platelet storage. This review will highlight some more recent knowledge gained regarding the platelet storage lesion and potential mediators of platelet transfusion reactions.
authors.affiliation: Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA. Craig_Morrell@URMC.Rochester.edu
authors.forename: Craig N
authors.initials: CN
authors.lastname: Morrell
mesh_terms: D001792:Blood Platelets / Q000276:immunology*; D001793:Blood Preservation / Q000009:adverse effects*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D015539:Platelet Activation; D017713:Platelet Transfusion / Q000009:adverse effects*
chemical_list: D007155:Immunologic Factors