title: GSK-3α/β kinases and amyloid production in vivo.
abstract: Arising from C. J. Phiel, C. A. Wilson, V. M.-Y. Lee & P. S. Klein  423, 435-439 (2003)A major unresolved issue in Alzheimer's disease is identifying the mechanisms that regulate proteolytic processing of amyloid precursor protein (APP)-glycogen synthase kinase-3 (GSK-3) isozymes are thought to be important in this regulation. Phiel et al. proposed that GSK-3α, but not GSK-3β, controls production of amyloid. We analysed the proteolytic processing of mouse and human APP in mouse brain in vivo in five different genetic and viral models. Our data do not yield evidence for either GSK-3α-mediated or GSK-3β-mediated control of APP processing in brain in vivo.
authors.affiliation: Experimental Genetics Group, KU Leuven, Leuven, Belgium.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jaworski
authors.forename: Ilse
authors.initials: I
authors.lastname: Dewachter
authors.forename: Benoit
authors.initials: B
authors.lastname: Lechat
authors.forename: Maarten
authors.initials: M
authors.lastname: Gees
authors.forename: Anna
authors.initials: A
authors.lastname: Kremer
authors.forename: David
authors.initials: D
authors.lastname: Demedts
authors.forename: Peter
authors.initials: P
authors.lastname: Borghgraef
authors.forename: Herman
authors.initials: H
authors.lastname: Devijver
authors.forename: Seb
authors.initials: S
authors.lastname: Kügler
authors.forename: Satish
authors.initials: S
authors.lastname: Patel
authors.forename: Jim R
authors.initials: JR
authors.lastname: Woodgett
authors.forename: Fred
authors.initials: F
authors.lastname: Van Leuven
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D038362:Glycogen Synthase Kinase 3