title: Effect of zafirlukast on capsular contracture around silicone implants in rats.
abstract: OBJECTIVE
  To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model.
  
  
  METHODS
  Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed.
  
  
  RESULTS
  In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants.
  
  
  CONCLUSIONS
  Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface.
authors.affiliation: Postgraduate Program in Plastic Surgery, Federal University of Sao Paulo (UNIFESP), Brazil. erika.mb@uol.com.br
authors.forename: Erika Malheiros
authors.initials: EM
authors.lastname: Bastos
authors.forename: Miguel
authors.initials: M
authors.lastname: Sabino Neto
authors.forename: Elvio Bueno
authors.initials: EB
authors.lastname: Garcia
authors.forename: Daniela Francescato
authors.initials: DF
authors.lastname: Veiga
authors.forename: Yuri Anna
authors.initials: YA
authors.lastname: Han
authors.forename: Rafael
authors.initials: R
authors.lastname: Denadai
authors.forename: Rafael de Almeida
authors.initials: Rde A
authors.lastname: Santos
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001940:Breast / Q000187:drug effects; D018427:Breast Implants; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D057910:Implant Capsular Contracture / Q000209:etiology / Q000517:prevention & control*; D007211:Indoles; D020024:Leukotriene Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D048448:Phenylcarbamates; D011312:Pressure; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020034:Silicone Gels; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D020034:Silicone Gels; D013449:Sulfonamides; D014105:Tosyl Compounds; C062735:zafirlukast