title: Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases.
abstract: Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients.
authors.affiliation: Infectious Disease Division, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Gomez
authors.forename: Martha
authors.initials: M
authors.lastname: Sanchez
authors.forename: Zonaira
authors.initials: Z
authors.lastname: Gul
authors.forename: Carl
authors.initials: C
authors.lastname: Urban
authors.forename: Noriel
authors.initials: N
authors.lastname: Mariano
authors.forename: Robert H K
authors.initials: RH
authors.lastname: Eng
authors.forename: David B
authors.initials: DB
authors.lastname: Huang
authors.forename: Tom
authors.initials: T
authors.lastname: Chiang