title: A systems-biology approach to yeast actin cables.
abstract: We focus on actin cables in yeast as a model system for understanding cytoskeletal organization and the workings of actin itself. In particular, we highlight quantitative approaches on the kinetics of actin-cable assembly and methods of measuring their morphology by image analysis. Actin cables described by these studies can span greater lengths than a thousand end-to-end actin-monomers. Because of this difference in length scales, control of the actin-cable system constitutes a junction between short-range interactions - among actin-monomers and nucleating, polymerization-facilitating, side-binding, severing, and cross-linking proteins - and the emergence of cell-scale physical form as embodied by the actin cables themselves.
authors.affiliation: Department of Physics, Lehigh University, Bethlehem, PA 18015, USA. tyler.gates.drake@gmail.com
authors.forename: Tyler
authors.initials: T
authors.lastname: Drake
authors.forename: Eddy
authors.initials: E
authors.lastname: Yusuf
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vavylonis
mesh_terms: D000199:Actins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D055503:Protein Multimerization; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology; D012568:Schizosaccharomyces / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D049490:Systems Biology / Q000379:methods*; D015003:Yeasts / Q000378:metabolism / Q000502:physiology*
chemical_list: D000199:Actins; D018797:Cell Cycle Proteins; D005656:Fungal Proteins