title: Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
abstract: Peroxiredoxins (Prdx), a family of antioxidant proteins, have important defensive roles in the degenerative brain diseases and neuronal cell death in adult subjects. However, little is known in the neonatal brain. Here, we studied the developmental expression of Prdxs and their response to dexamethasone in the perinatal rat brain. Prdx 1 expression increased during late gestations and peaked at postnatal-day 1, when its expression gradually decreased. Prdx 2 expression remained largely unchanged. Prdx 6 expression continually increased as growing. Using immunohistochemistry, each Prdx showed a strong expression in the cerebral cortex and hippocampus. Prdx 1 was strongly expressed in the corpus callosum. The dexamethasone injection increased the expression of Prdx 6. In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment.
authors.affiliation: Department of Pediatrics, Gachon University of Medicine and Science, Incheon, Republic of Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Shim
authors.forename: Han-Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Ee-Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D002540:Cerebral Cortex / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D003337:Corpus Callosum / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004790:Enzyme Induction / Q000187:drug effects; D005326:Fetal Proteins / Q000096:biosynthesis / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D005865:Gestational Age; D006624:Hippocampus / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D007274:Injections, Intraperitoneal; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D018384:Oxidative Stress; D054465:Peroxiredoxin VI / Q000096:biosynthesis* / Q000235:genetics; D054464:Peroxiredoxins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005326:Fetal Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D003907:Dexamethasone; C489898:Prdx1 protein, rat; D054465:Peroxiredoxin VI; D054464:Peroxiredoxins; C515984:Prdx6 protein, rat