title: [Targeted therapy of melanoma: fact or fiction?].
abstract: Advanced malignant melanoma is incurable by the current means of therapy. Traditional morphological classification (nodular melanoma, lentigo maligna melanoma, nevoid melanoma etc.) does not have any significant prognostic or predictive impact. Recent advances in molecular pathogenesis and the availability of targeted therapies have produced several positive results. In the near future, the main challenge for pathologists, geneticists and oncologists will be the identification of accurate therapeutic targets, as well as mechanisms of resistance, in melanoma in the particular patient in care.
authors.affiliation: Oddelenie patológie UNLP Kosice, pracovisko Trieda SNP 1. svajdler@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Svajdler
authors.forename: B
authors.initials: B
authors.lastname: Rychlý
authors.forename: M
authors.initials: M
authors.lastname: Benický
mesh_terms: D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000235:genetics; D058990:Molecular Targeted Therapy; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf