title: Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density.
abstract: OBJECTIVE
  To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women.
  
  
  METHODS
  A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in the ER gene were studied by the polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  The frequencies of the ERα PVuII genotypes PP, Pp and pp were 20%, 54.4% and 25.6% in premenopausal and 24.8%, 44.8% and 30.4% in postmenopausal women, respectively. The frequencies of the ER XbaI genotypes XX, Xx, xx were 16.8%, 48.8% and 34.4% in premenopausal and 16.8%, 48% and 35.2% in postmenopausal women, respectively. There was no difference in the frequencies of ER gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between ER PvuII and XbaI genotypes in premenopausal and postmenopausal women.
  
  
  CONCLUSIONS
  ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.
authors.affiliation: Department of Internal Medicine, Section of Endocrinology and Metabolism, Marmara University Hospital, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: D G
authors.initials: DG
authors.lastname: Yavuz
authors.forename: T
authors.initials: T
authors.lastname: Yoldemir
authors.forename: K
authors.initials: K
authors.lastname: Ozaltun
authors.forename: M
authors.initials: M
authors.lastname: Erenus
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000502:physiology*; D017698:Postmenopause / Q000235:genetics* / Q000378:metabolism; D014421:Turkey
chemical_list: D047628:Estrogen Receptor alpha