title: Intracranial calcification in early infantile Krabbe disease: nothing new under the sun.
abstract: We report the cases of three children, one male and two females, with a diagnosis of early infantile Krabbe disease demonstrating intracranial calcification on computed tomography (CT). The pattern of calcification was similar in all individuals and involved the internal capsule and cerebral white matter. The presence of calcification caused some diagnostic confusion in what was otherwise a typical clinical and radiological presentation. This finding is not new and has previously been described in publications from the 1980s and 1990s reporting the CT and magnetic resonance imaging appearances of Krabbe disease. With increasing use of magnetic resonance as the first imaging modality for investigation of neurological disorders, characteristic CT appearances may be forgotten. This report serves as a reminder that Krabbe disease should be included in the differential diagnosis of disorders causing intracranial calcification.
authors.affiliation: Department of Paediatric Neurology, Leeds General Infirmary, Leeds, UK. jh.livingston@leedsth.nhs.uk
authors.forename: John H
authors.initials: JH
authors.lastname: Livingston
authors.forename: Claudio
authors.initials: C
authors.lastname: Graziano
authors.forename: Karen
authors.initials: K
authors.lastname: Pysden
authors.forename: Yanick J
authors.initials: YJ
authors.lastname: Crow
authors.forename: Santosh R
authors.initials: SR
authors.lastname: Mordekar
authors.forename: Isabella
authors.initials: I
authors.lastname: Moroni
authors.forename: Graziella
authors.initials: G
authors.lastname: Uziel
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed