title: Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study.
abstract: A randomized, double-blind, and placebo-controlled clinical study was performed to evaluate the antioxidant effects of fermented sea tangle (FST) on healthy volunteers with high levels of γ-glutamyltransferse (γ-GT). Forty-eight participants were divided into a placebo group and an FST group that received FST (1.5 g/day) for 4 weeks. Serum γ-GT, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were determined before and after the trial. Administering FST significantly decreased serum levels of γ-GT and MDA. Additionally, SOD and CAT activities were significantly augmented compared to those in the placebo group after 4 weeks, but no significant alteration was observed in GPx activity compared to that in the placebo group. Our findings indicate that FST enhanced the antioxidant defense system in a healthy population and may be useful as a functional food ingredient.
authors.affiliation: Marine Bioprocess Co. Ltd., Busan 619-912, Republic of Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Kang
authors.forename: Bae-Jin
authors.initials: BJ
authors.lastname: Lee
authors.forename: Jung Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Byung-Hyouk
authors.initials: BH
authors.lastname: Nam
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Cha
authors.forename: Young-Mog
authors.initials: YM
authors.lastname: Kim
authors.forename: Chang-Bum
authors.initials: CB
authors.lastname: Ahn
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.forename: In Soon
authors.initials: IS
authors.lastname: Choi
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Je
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000097:blood; D004311:Double-Blind Method; D005285:Fermentation; D006801:Humans; D052196:Levilactobacillus brevis / Q000378:metabolism*; D007795:Laminaria / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D010919:Placebos; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D000975:Antioxidants; D010919:Placebos; D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase