title: A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system.
abstract: We describe the design and initial performance results of a multi-sample dissolution dynamic-nuclear-polarization (DNP) polarizer based on a Helium-temperature NMR cryostat for use in a wide-bore NMR magnet with a room-temperature bore. The system is designed to accommodate up to six samples in a revolver-style sample changer that allows changing samples at liquid-Helium temperature and at pressures ranging from ambient pressure down to 1 mbar. The multi-sample setup is motivated by the desire to do repetitive in vivo measurements and to characterize the DNP process by investigating samples of different chemical composition. The system can be loaded with up to six samples simultaneously to reduce sample loading and unloading. Therefore, series of experiments can be carried out faster and more reliably. The DNP probe contains an oversized microwave cavity and includes EPR and NMR capabilities for monitoring the DNP process. In the solid state, DNP enhancements corresponding to ∼45% polarization for [1-(13)C]pyruvic acid with a trityl radical have been measured. In the initial liquid-state acquisition experiments described here, the polarization was found to be ∼13%, corresponding to an enhancement factor exceeding 16,000 relative to thermal polarization at 9.4 T and ambient temperature.
authors.affiliation: Physical Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Batel
authors.forename: Marcin
authors.initials: M
authors.lastname: Krajewski
authors.forename: Kilian
authors.initials: K
authors.lastname: Weiss
authors.forename: Oliver
authors.initials: O
authors.lastname: With
authors.forename: Alexander
authors.initials: A
authors.lastname: Däpp
authors.forename: Andreas
authors.initials: A
authors.lastname: Hunkeler
authors.forename: Martin
authors.initials: M
authors.lastname: Gimersky
authors.forename: Klaas P
authors.initials: KP
authors.lastname: Pruessmann
authors.forename: Peter
authors.initials: P
authors.lastname: Boesiger
authors.forename: Beat H
authors.initials: BH
authors.lastname: Meier
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Matthias
authors.initials: M
authors.lastname: Ernst
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006371:Helium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008872:Microwaves; D018401:Sample Size; D013048:Specimen Handling / Q000295:instrumentation*
chemical_list: D006371:Helium