title: Closing one of the last gaps in polyionene compositions: alkyloxyethylammonium ionenes as fast-acting biocides.
abstract: Alkyloxyethylammonium ionenes are reported as biocompatible biocides with a time of biocidal action within a few minutes. The presence of both ethoxyethyl and aliphatic spacers besides long alkyl chain substituents on the quaternary nitrogen atom differentiates these biocides structurally from the known polyionenes. The influence of alkyl spacer length, counter ion and length of the pendant alkyl groups on the antibacterial properties is studied. E. coli is adopted as a test organism. MIC and MBC values are determined via broth dilution methods; time-dependent tests are accomplished by determining the number of viable cells with the spread-plate method after different contact times. Structural characterization is conducted via NMR and mass spectrometry techniques.
authors.affiliation: Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein-Straße, 35032 Marburg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mattheis
authors.forename: Mengyao
authors.initials: M
authors.lastname: Zheng
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009861:Onium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013329:Structure-Activity Relationship
chemical_list: D001672:Biocompatible Materials; D004202:Disinfectants; D009861:Onium Compounds