title: Potential adverse effects of norepinephrine on cortical somatosensory-evoked potentials during carotid endarterectomy: a case report.
abstract: The cerebral metabolic and vascular effects of intravenous norepinephrine have been shown in an animal model using somatosensory-evoked potentials (SSEPs). A case of intravenous norepinephrine resulting in a decrease in SSEP amplitude (of greater than 50%) despite no significant change in blood pressure, prior to cross-clamping during a carotid endarterectomy is presented. This finding may have implications for the use of norepinephrine in the critical care unit as well as the operating room.
authors.affiliation: Department of Anesthesiology, St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA. philb99@optonline.net
authors.forename: Philip David
authors.initials: PD
authors.lastname: Bamberger
authors.forename: Sedat
authors.initials: S
authors.lastname: Ulkatan
authors.forename: Estela Lladó
authors.initials: EL
authors.lastname: Carbó
authors.forename: Vedran
authors.initials: V
authors.lastname: Deletis
authors.forename: Alan I
authors.initials: AI
authors.lastname: Benvenisty
mesh_terms: D000368:Aged; D001794:Blood Pressure; D016894:Endarterectomy, Carotid / Q000379:methods*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D009638:Norepinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents; D009638:Norepinephrine