title: Treatment of subepidermal immunobullous diseases.
abstract: The subepidermal immunobullous diseases are a group of autoimmune blistering disorders of the skin and mucous membranes that share the common features of autoantibody deposition and blister formation at the dermal-epidermal junction or basement membrane. This group includes bullous pemphigoid, linear IgA disease, dermatitis herpetiformis, and epidermolysis bullosa acquisita, among others. Although these disorders share some common features, each disease is unique in its clinical presentation, histopathology, and immunofluorescence patterns, which allows for accurate diagnosis and disease-specific treatment strategy. Treatment of these disorders is complex and requires expert knowledge of disease pathogenesis. We review common treatment approaches for each of these disorders.
authors.affiliation: Department of Dermatology, University of North Carolina at Chapel Hill, School of Medicine, USA. donna_culton@med.unc.edu
authors.forename: Donna A
authors.initials: DA
authors.lastname: Culton
authors.forename: Luis A
authors.initials: LA
authors.lastname: Diaz
mesh_terms: D003874:Dermatitis Herpetiformis / Q000188:drug therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy; D010391:Pemphigoid, Bullous / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D003879:Dermatologic Agents; D007166:Immunosuppressive Agents