title: Miliaria rubra and thrombocytosis in pseudohypoaldosteronism: case report.
abstract: Pseudohypoaldosteronism type 1 (PHA1) is a disease involving a state of renal tubular unresponsiveness to the action of aldosterone and characterized by excessive salt loss in the urine, hyperkalemia, and metabolic acidosis. In kidney, PHA1 may occur primarily by mutations in the subunits of the sodium channel or in the mineralocorticoid receptors, and secondarily by several renal disorders. Miliaria rubra and thrombocytosis are reported in a 6-month-old girl with PHA1. In patients with PHA1, miliaria rubra-like cutaneous eruptions are suggested to occur due to obstruction of eccrine sweat glands through inflammation caused by excessive sodium excretion in sweat during hyponatremic crises. The presence of thrombocytosis in patients with PHA1 has not been previously reported. A hypothesis is proposed suggesting that sympathetic activation which provides vascular tonus during sodium excretion in sweat and salt-depletion crisis may play a role in the development of eruptions and thrombocytosis in patients with PHA1.
authors.affiliation: Department of Pediatrics, Ministry of Health Bakirkoy Maternity and Children Education Hospital, Istanbul, Turkey. hasanonal@hotmail.com
authors.forename: Hasan
authors.initials: H
authors.lastname: Onal
authors.forename: Erdal
authors.initials: E
authors.lastname: Adal
authors.forename: Atilla
authors.initials: A
authors.lastname: Ersen
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Onal
authors.forename: Gonca
authors.initials: G
authors.lastname: Keskindemirci
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D008883:Miliaria / Q000150:complications* / Q000188:drug therapy; D011546:Pseudohypoaldosteronism / Q000150:complications* / Q000188:drug therapy; D013922:Thrombocytosis / Q000150:complications* / Q000188:drug therapy