title: Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers.
abstract: A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria and induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou, 510632, PR China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Yum-Shing
authors.initials: YS
authors.lastname: Wong
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
authors.forename: Cundong
authors.initials: C
authors.lastname: Fan
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001562:Benzimidazoles / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D009942:Organometallic Compounds; D012428:Ruthenium; C031000:benzimidazole