title: Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines.
abstract: Inflammatory cytokines, such as interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α), induce the intracellular signaling pathway leading to the activation of nuclear factor κB (NF-κB). A series of eudesmane-type sesquiterpene lactones possessing an α-methylene γ-lactone group and/or an α-bromo ketone group were synthesized and evaluated for their inhibitory effects on the NF-κB-dependent gene expression and signaling pathway. Our present study reveals that eudesmane-type α-methylene γ-lactones and α-bromo ketones inhibit multiple steps in the NF-κB signaling pathway induced by IL-1α and TNF-α.
authors.affiliation: Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Tamura
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Chen
authors.forename: Miwako
authors.initials: M
authors.lastname: Shinozaki
authors.forename: Kei
authors.initials: K
authors.lastname: Arao
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.forename: Wanxia
authors.initials: W
authors.lastname: Tang
authors.forename: Seiya
authors.initials: S
authors.lastname: Hirano
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ogura
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Mitsui
authors.forename: Shigeru
authors.initials: S
authors.lastname: Taketani
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
mesh_terms: D000465:Algorithms; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016207:Cytokines / Q000378:metabolism*; D019281:Dimerization; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D053582:Interleukin-1alpha / Q000378:metabolism; D007659:Ketones / Q000737:chemistry; D007783:Lactones / Q000737:chemistry*; D008956:Models, Chemical; D016328:NF-kappa B / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000494:pharmacology*; D015398:Signal Transduction; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D053582:Interleukin-1alpha; D007659:Ketones; D007783:Lactones; D016328:NF-kappa B; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; C015872:eudesmane