title: Valvular heart disease with the use of fenfluramine-phentermine.
abstract: Exposure to the anorectic drug fenfluramine, alone or in combination with phentermine, a noradrenergic central nervous system stimulant, has been associated with unusual cardiac valvular morphology and resultant regurgitation of the left- and right-sided heart valves. The prevalence of significant valvular disease associated with the use of these anorectic drugs is reported to be as high as 23%. Herein, we report the occurrence of multivalvular disease and pulmonary hypertension associated with fenfluramine-phentermine use, discovered in an obese 59-year-old woman before expected gastric bypass surgery.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona 85259, USA.
authors.forename: Phani
authors.initials: P
authors.lastname: Surapaneni
authors.forename: Karyne L
authors.initials: KL
authors.lastname: Vinales
authors.forename: Mohammad Q
authors.initials: MQ
authors.lastname: Najib
authors.forename: Hari P
authors.initials: HP
authors.lastname: Chaliki
mesh_terms: D019440:Anti-Obesity Agents / Q000009:adverse effects*; D004338:Drug Combinations; D018618:Echocardiography, Doppler, Color; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D015390:Gastric Bypass; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006351:Heart Valves / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000601:surgery; D010645:Phentermine / Q000009:adverse effects*
chemical_list: D019440:Anti-Obesity Agents; D004338:Drug Combinations; D005277:Fenfluramine; D010645:Phentermine