title: Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.
abstract: A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA. timothy.donohoe@chem.ox.ac.uk
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Donohoe
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Kabeshov
authors.forename: Akshat H
authors.initials: AH
authors.lastname: Rathi
authors.forename: Ian E D
authors.initials: IE
authors.lastname: Smith
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D007093:Imidazoles; D011725:Pyridines; D013844:Thiazoles; D053778:Thiazolidines