title: A novel electrochemical sensor for probing doxepin created on a glassy carbon electrode modified with poly(4-amino- benzoic acid)/multi-walled carbon nanotubes composite film.
abstract: A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. The sensor was characterized by scanning electron microscopy and electrochemical methods. It was observed that poly(4-ABA)/MWNTs/GCE showed excellent preconcentration function and electrocatalytic activities towards doxepin. Under the selected conditions, the anodic peak current was linear to the logarithm of doxepin concentration in the range from 1.0 × 10(-9) to 1.0 × 10(-6) M, and the detection limit obtained was 1.0 × 10(-10) M. The poly(4-ABA)/MWNTs/GCE was successfully applied in the measurement of doxepin in commercial pharmaceutical formulations, and the analytical accuracy was confirmed by comparison with a conventional ultraviolet spectrophotometry assay.
authors.affiliation: Department of Chemistry & Center of Analysis and Measurement, Fudan University, Handan Road 220#, Shanghai 200433, China. 071022016@fudan.edu.cn
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Zhou
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.forename: Ji-Lie
authors.initials: JL
authors.lastname: Kong
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D004316:Doxepin / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D037742:Nanotubes, Carbon; D004316:Doxepin; D002244:Carbon; D010129:4-Aminobenzoic Acid