title: [Risk of reactivation or exacerbation of an infectious disease during iatrogenic immunosuppression or immune reconstitution].
abstract: Drug induced immunosuppression increases the risk of infections, both occurring as reactivation of latent-infections and occurrence of recent opportunistic ones. Thus, a careful mandatory infection screening is needed before immunosuppressive drugs onset. In addition, immune reconstitution after immunosuppression cessation can be associated with acute worsening of the underlying infection leading to the immune reconstitution inflammatory syndrome that must be differenciated from infection recurrences, relapses or resistance to antiinfective agents.
authors.affiliation: Université de Strasbourg, service de médecine interne, endocrinologie et nutrition, CHU de Strasbourg, hôpital Hautepierre, laboratoire d'immunogénétique moléculaire humaine, 67098 Strasbourg, France. anne.bourgarit-durand@chru-strasbourg.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Bourgarit
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology*; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000209:etiology*
chemical_list: D007166:Immunosuppressive Agents