title: Performance of the QuickVue Influenza A+B rapid test for pandemic H1N1 (2009) virus infection in adults.
abstract: To investigate the diagnostic accuracy of the QuickVue® Influenza A+B rapid test we conducted a prospective observational study in which this rapid test was compared with a real-time reverse transcription polymerase chain reaction (RT-PCR) for pandemic influenza A H1N1 (2009) infection in Austrian adults. The sensitivity, specificity, and positive and negative predictive values of the QuickVue test compared with the RT-PCR were 26% (95% CI 18-35), 98% (95% CI 92-100), 94% (95% CI 80-99) and 50% (95% CI 42-58), respectively. The prevalence of pandemic H1N1 (2009) virus infection among the 209 patients included in the study was 57%. Our data suggest that a positive QuickVue test provides considerable information for the diagnosis of pandemic influenza A H1N1 (2009) virus infection in young adults but that a negative QuickVue test result should, if relevant for patient management or public health measures, be verified using PCR.
authors.affiliation: Department of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. wolfgang.poeppl@meduniwien.ac.at
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Poeppl
authors.forename: Harald
authors.initials: H
authors.lastname: Herkner
authors.forename: Heinz
authors.initials: H
authors.lastname: Burgmann
authors.forename: Tom
authors.initials: T
authors.lastname: Pustelnik
authors.forename: Gerhard
authors.initials: G
authors.lastname: Mooseder
authors.forename: Theresia
authors.initials: T
authors.lastname: Popow-Kraupp
authors.forename: Monika
authors.initials: M
authors.lastname: Redlberger-Fritz
mesh_terms: D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000235:genetics / Q000821:virology*; D008297:Male; D058873:Pandemics; D011379:Prognosis; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D060888:Real-Time Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D019562:Viral Load / Q000235:genetics*; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D011933:Reagent Kits, Diagnostic