title: Intracolonial allocation of trisoxazole macrolides in the sponge Pachastrissa nux.
abstract: Pachastrissa nux has two distinctive growth forms in one colony, i.e., the protruding gorgonian-shaped capitum and the substratum-attached irregular-shaped base. The sponge has the ability to allocate specifically its major secondary metabolites to the two parts in different levels. Using two cytotoxic trisoxazole macrolides, kabiramides C (2) and G (3), as chemical markers, it was found that the capitum accumulated higher contents of either or both compounds than did the base. However, there were neither inductive nor suppressive correlations among the allocation profiles of either compound in either part of the sponge. The allocation of kabiramides was a trade-off with the structural materials involved in reinforcing the strength of the sponge. To date, this is the second report that provides evidence of the specific allocation of bioactive metabolites in two distinctively different organ-like structures in a single sponge colony.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
authors.forename: Thanchanok
authors.initials: T
authors.lastname: Sirirak
authors.forename: Niwan
authors.initials: N
authors.lastname: Intaraksa
authors.forename: Sireewan
authors.initials: S
authors.lastname: Kaewsuwan
authors.forename: Supreeya
authors.initials: S
authors.lastname: Yuenyongsawad
authors.forename: Khanit
authors.initials: K
authors.lastname: Suwanborirux
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D018942:Macrolides / Q000302:isolation & purification*; D015394:Molecular Structure; D010080:Oxazoles / Q000302:isolation & purification*; D011161:Porifera / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*
chemical_list: D018942:Macrolides; D010080:Oxazoles; C489776:kabiramide C; C572171:kabiramide G