title: Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population.
abstract: Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and disease severity after IAV infection. We found that the expression level of OPN was increased in mice infected with IAV. The OPN knockout (KO) mice exhibited a severe pathological phenotype and the survival rate decreased after the lethal IAV infection, compared to the wild type mice, while the survival rate increased in OPN transgenic (Tg) mice. The population of natural killer (NK) cells significantly decreased in OPN KO mice at day 5 after the infection, whereas, it increased in OPN Tg mice. These results suggest that OPN plays an important role in host defense against IAV infection through the regulation of NK cell population.
authors.affiliation: Department of Bioresources, Hokkaido University Research Center for Zoonosis Control, Kita-ku, Sapporo, Hokkaido, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwai
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Junko
authors.initials: J
authors.lastname: Morimoto
authors.forename: Ayato
authors.initials: A
authors.lastname: Takada
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Maruyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kida
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Uede
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D009980:Influenza A virus; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000473:pathology; D053495:Osteopontin / Q000235:genetics / Q000502:physiology*; D011024:Pneumonia, Viral / Q000276:immunology* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D053495:Osteopontin