title: [Investigation of different pregnant results of pregnant women infected with toxoplasma gondii in Nanjing region].
abstract: OBJECTIVE
  To explore the influence of Toxoplasma gondii infection on pregnant results during different pregnancies of women.
  
  
  METHODS
  The antibodies of IgG and IgM against Toxoplasma gondii in peripheral blood were detected by ELISA in 6 849 pregnant women and the antibody of IgM against Toxoplasma gondii in cord blood was also detected in 1 032 newborns in Nanjing City. The general status of these women was investigated with questionnaire, and the outcome of pregnancies of the women was followed up.
  
  
  RESULTS
  A total of 6 849 pregnant women were screened, 438 persons were found with antibodies against Toxoplasma gondii, and the positive rate was 6.4%. Among them, 87 women were IgM positive accounting for 19.9%, and 351 IgG positive accounting for 80.1%. Totally 1 032 newborns were screened and they were divided into a normal group and a deformed group according to their health. Among them, the IgM positive rates were 0.6% in the normal group and 28.13% in the deformed group respectively, and there was a statistically significant deference between 2 groups (P < 0.01). The exposure to animals and bad eating habits were the main risk factors for Toxoplasma gondii infection.
  
  
  CONCLUSIONS
  Toxoplasma infection can lead to different pregnancy outcomes in pregnant women. The detection of IgM antibody against Toxoplasma gondii may contribute to screening deformed newborns.
authors.affiliation: Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Xi-Wei
authors.initials: XW
authors.lastname: Chen
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D011256:Pregnancy Outcome; D037841:Pregnant People; D014122:Toxoplasma / Q000276:immunology* / Q000302:isolation & purification; D014123:Toxoplasmosis / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology / Q000635:transmission; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M