title: Brominated compounds from marine sponges of the genus Aplysina and a compilation of their 13C NMR spectral data.
abstract: Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their (13)C NMR data is also part of the review. For this purpose 138 references were consulted.
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Narlize Silva
authors.initials: NS
authors.lastname: Lira
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Ricardo Carneiro
authors.initials: RC
authors.lastname: Montes
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Marcelo Sobral da
authors.initials: MSD
authors.lastname: Silva
authors.affiliation: Department of Pharmacy, State University of Paraiba, Campina Grande 58100-000, PB, Brazil.
authors.forename: Emidio V L da
authors.initials: EVLD
authors.lastname: Cunha
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Petronio Filgueiras de
authors.initials: PF
authors.lastname: Athayde-Filho
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Luis Cezar
authors.initials: LC
authors.lastname: Rodrigues
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Celidarque da Silva
authors.initials: CDS
authors.lastname: Dias
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D017605:Bromine Compounds / Q000737:chemistry* / Q000302:isolation & purification; D002247:Carbon Isotopes; D054879:Halogenation; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D017605:Bromine Compounds; D002247:Carbon Isotopes