title: Acellular vaccines for ovine brucellosis: a safer alternative against a worldwide disease.
abstract: Ovine brucellosis is a very contagious zoonotic disease distributed worldwide and constitutes a very important zoosanitary and economic problem. The control of the disease includes animal vaccination and slaughter of infected flocks. However, the commercially available vaccine in most countries is based on the attenuated strain Brucella melitensis Rev 1, which presents important safety drawbacks. This review is focused on the most recent and promising acellular vaccine proposals.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, University of Navarra, C/Irunlarrea, 1 31008-Pamplona, Spain.
authors.forename: Raquel Da Costa
authors.initials: Rda C
authors.lastname: Martins
authors.forename: Juan M
authors.initials: JM
authors.lastname: Irache
authors.forename: Carlos
authors.initials: C
authors.lastname: Gamazo
mesh_terms: D000818:Animals; D002004:Brucella Vaccine / Q000276:immunology*; D017347:Brucella melitensis / Q000472:pathogenicity; D042061:Brucella ovis / Q000472:pathogenicity; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary; D006801:Humans; D012756:Sheep / Q000382:microbiology; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary*; D022282:Vaccines, Acellular / Q000276:immunology*
chemical_list: D002004:Brucella Vaccine; D022282:Vaccines, Acellular