title: [Molecular-biological and antigenic features of H5N1 subtype highly pathogenic influenza virus strains isolated in southern Siberia in 2005-2009].
abstract: OBJECTIVE
  Study of molecular-biological and antigenic features of H5N1 subtype virus strains isolated in southern Siberia in 2005-2009.
  
  
  METHODS
  Study was performed by using standard procedures according to WHO recommendations.
  
  
  RESULTS
  Hemagglutinin gene of H5N1 subtype virus strain isolated in Siberia belongs to 2 genetical lineages: 2.2 and 2.3.2. Strains of these 2 lineages have antigenic differences. All of the strains are highly pathogenic for chicken and white mice.
  
  
  CONCLUSIONS
  H5N1 subtype highly pathogenic influenza virus variants of 2 different antigenic lineages that have antigenic differences circulated in Siberia in 2005-2009. A possible role of antigenic drift in evolution of H5N1 subtype influenza virus is discussed.
authors.forename: K A
authors.initials: KA
authors.lastname: Sharshov
authors.forename: A G
authors.initials: AG
authors.lastname: Durymanov
authors.forename: A A
authors.initials: AA
authors.lastname: Romanovskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Zaĭkovskaia
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Marchenko
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Silko
authors.forename: F A
authors.initials: FA
authors.lastname: Il'inykh
authors.forename: I M
authors.initials: IM
authors.lastname: Susloparov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Alekseev
authors.forename: A M
authors.initials: AM
authors.lastname: Shestopalov
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D001717:Birds / Q000821:virology; D002645:Chickens / Q000821:virology; D006389:Hemagglutinins, Viral / Q000235:genetics*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010802:Phylogeny; D012800:Siberia / Q000453:epidemiology
chemical_list: D000956:Antigens, Viral; D006389:Hemagglutinins, Viral