title: [Vesicoureteral reflux in adults].
abstract: Vesicoureteral reflux (VUR) may be congenital or acquired. The most frequent form of congenital VUR is primary VUR. Its prevalence in adults is not exactly known, but it is higher in women, whose greater propensity for urinary tract infections increases the likelihood of an instrumental examination leading to the diagnosis of less severe cases. In men, even severe VUR may go undiagnosed for a long time. Primary VUR is due to a defect in the valve mechanism of the ureterovesical junction. In physiological conditions, the terminal ureter enters the bladder wall obliquely and bladder contraction leads to compression of this intravesical portion. Abnormal length of the intravesical portion of the ureter due to a genetic mutation (whose location is yet to be established) leads to VUR. In its less severe forms VUR may be asymptomatic, but in 50-70% of cases it manifests with recurrent cystitis or pyelonephritis. The manifestations leading to a diagnosis of VUR in adults, besides urinary tract infections, are proteinuria, renal failure and hypertension. The gold-standard diagnostic examination is a micturating cystourethrogram. Reflux nephropathy develops as a result of a pathogenetic mechanism unrelated to high cavity pressure or urinary tract infections but due to reduced formation of the normal renal parenchyma (hypoplasia or dysplasia). Abnormal renal parenchyma development is attributable to the same genes that control the development of the ureters and ureterovesical junction. VUR is considered only a marker of this abnormal development, playing no role in scar formation. There is no conclusive evidence regarding the indications for VUR correction. However, the risk that VUR leads to recurrent pyelonephritis and reflux nephropathy must be kept in mind. VUR certainly has to be corrected in women who contemplate pregnancy.
authors.affiliation: Divisione di Nefrologia e Dialisi, Ospedale S. Giovanni Bosco, Torino, Italy. cristiana.rollino@liberto.it
authors.forename: Cristiana
authors.initials: C
authors.lastname: Rollino
authors.forename: Leonardo
authors.initials: L
authors.lastname: D'Urso
authors.forename: Giulietta
authors.initials: G
authors.lastname: Beltrame
authors.forename: Michela
authors.initials: M
authors.lastname: Ferro
authors.forename: Giacomo
authors.initials: G
authors.lastname: Quattrocchio
authors.forename: Francesco
authors.initials: F
authors.lastname: Quarello
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003556:Cystitis / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007558:Italy / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D011507:Proteinuria / Q000209:etiology; D011704:Pyelonephritis / Q000209:etiology; D012307:Risk Factors; D017678:Sex Distribution; D014513:Ureter / Q000002:abnormalities; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D013520:Urologic Surgical Procedures / Q000379:methods; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents