title: The NF-Y/p53 liaison: well beyond repression.
abstract: NF-Y is a sequence-specific transcription factor - TF - targeting the common CCAAT promoter element. p53 is a master TF controlling the response to stress signals endangering genome integrity, often mutated in human cancers. The NF-Y/p53 - and p63, p73 - interaction results in transcriptional repression of a subset of genes within the vast NF-Y regulome under DNA-damage conditions. Recent data shows that NF-Y is also involved in pro-apoptotic activities, either directly, by mediating p53 transcriptional activation, or indirectly, by being targeted by a non coding RNA, PANDA. The picture is subverted in cells carrying Gain-of-function mutant p53, through interactions with TopBP1, a protein also involved in DNA repair and replication. In summary, the connection between p53 and NF-Y is crucial in determining cell survival or death.
authors.affiliation: Dipartimento di Biologia, Università degli Studi di Modena e Reggio Emilia, Via Campi 213/d, 41100 Modena, Italy.
authors.forename: Carol
authors.initials: C
authors.lastname: Imbriano
authors.forename: Nerina
authors.initials: N
authors.lastname: Gnesutta
authors.forename: Roberto
authors.initials: R
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D023081:CCAAT-Binding Factor / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D023081:CCAAT-Binding Factor; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53