title: A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children.
abstract: Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T(reg) cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T(reg)-associated cytokines of children and adults. IL-6, IL-10 and TGF-β1 levels and Foxp3(+) cell numbers were higher, but IL-1β, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T(reg) instead of Th17 cell response to H. pylori-infection predominates in children.
authors.affiliation: Laboratory of Research in Bacteriology, Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190, Sala 216, 30130-100 Belo Horizonte, Brazil.
authors.forename: Fabrício
authors.initials: F
authors.lastname: Freire de Melo
authors.forename: Andreia Maria Camargos
authors.initials: AM
authors.lastname: Rocha
authors.forename: Gifone Aguiar
authors.initials: GA
authors.lastname: Rocha
authors.forename: Silvia Helena Sousa Pietra
authors.initials: SH
authors.lastname: Pedroso
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Assis Batista
authors.forename: Lúcia Porto
authors.initials: LP
authors.lastname: Fonseca de Castro
authors.forename: Simone Diniz
authors.initials: SD
authors.lastname: Carvalho
authors.forename: Paulo Fernando Souto
authors.initials: PF
authors.lastname: Bittencourt
authors.forename: Celso Afonso
authors.initials: CA
authors.lastname: de Oliveira
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Corrêa-Oliveira
authors.forename: Dulciene Maria
authors.initials: DM
authors.lastname: Magalhães Queiroz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D016481:Helicobacter Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors