title: Clonal expansions of CD8⁺ T cells in latently HSV-1-infected human trigeminal ganglia.
abstract: Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
authors.affiliation: Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377 Munich, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Held
authors.forename: Ingrid
authors.initials: I
authors.lastname: Eiglmeier
authors.forename: Susanne
authors.initials: S
authors.lastname: Himmelein
authors.forename: Inga
authors.initials: I
authors.lastname: Sinicina
authors.forename: Thomas
authors.initials: T
authors.lastname: Brandt
authors.forename: Diethilde
authors.initials: D
authors.lastname: Theil
authors.forename: Klaus
authors.initials: K
authors.lastname: Dornmair
authors.forename: Tobias
authors.initials: T
authors.lastname: Derfuss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D001344:Autopsy; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D002999:Clone Cells / Q000276:immunology / Q000821:virology; D022801:Complementarity Determining Regions / Q000235:genetics / Q000276:immunology; D005260:Female; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000276:immunology; D012668:Trigeminal Ganglion / Q000276:immunology / Q000821:virology*; D017735:Virus Latency / Q000276:immunology*
chemical_list: D022801:Complementarity Determining Regions; D016693:Receptors, Antigen, T-Cell, alpha-beta