title: [Use of desmopressin in children with inherited platelet dysfunctions undergoing adenotonsillar procedures].
abstract: OBJECTIVE
  Adenotonsillar surgery represents a major haemostatic challenge in paediatric patients with mild inherited platelet dysfunction. While there are recommendations for perioperative haemostatic management, there are no reports of the outcomes with the different recommendations in these children when undergoing adenotonsillectomy. Our objective was to evaluate the management of perioperative bleeding with desmopressin in children with mild platelet dysfunctions who underwent adenotonsillar surgery in our hospital.
  
  
  METHODS
  We performed a retrospective study aimed at determining the perioperative bleeding and complication rate in children with mild inherited platelet dysfunction in whom desmopressin was used while undergoing adenotonsillar procedures.
  
  
  RESULTS
  Between 2004 and 2010, 27 children with mild inherited platelet dysfunction underwent adenotonsillar procedures in our hospital and were treated with desmopressin. One patient developed perioperative bleeding (3.7%) and there was 1 child (3.7%) who presented transitory hypotension as a side effect of desmopressin.
  
  
  CONCLUSIONS
  The use of desmopressin allowed adequate perioperative bleeding prophylaxis management in children with mild inherited platelet dysfunction who underwent adenotonsillar procedures without presenting severe complications.
authors.affiliation: Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Raimundo J
authors.initials: RJ
authors.lastname: García-Matte
authors.forename: M Constanza
authors.initials: MC
authors.lastname: Beltran
authors.forename: Ximena
authors.initials: X
authors.lastname: Fonseca
authors.forename: Francisco
authors.initials: F
authors.lastname: Barriga
authors.forename: Angélica
authors.initials: A
authors.lastname: Wietstruck
authors.forename: Pamela
authors.initials: P
authors.lastname: Zúñiga
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000233:Adenoidectomy; D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001791:Blood Platelet Disorders / Q000150:complications / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003061:Codeine / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006474:Hemorrhagic Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced; D019106:Postoperative Hemorrhage / Q000453:epidemiology / Q000517:prevention & control*; D011229:Preanesthetic Medication; D017483:Receptors, Vasopressin / Q000187:drug effects; D014068:Tonsillectomy; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D017483:Receptors, Vasopressin; D000082:Acetaminophen; D014148:Tranexamic Acid; D003894:Deamino Arginine Vasopressin; D003061:Codeine