title: Development and characterization of 5 canine B-cell lymphoma cell lines.
abstract: Canine and human lymphoma share similar characteristics in disease development and response to therapy. Translational research can be furthered using tools such as canine cell lines to model therapeutic compounds and strategies. We developed 5 B-cell lymphoma cell lines from dogs with confirmed large B-cell lymphoma. These cell lines were CD3, CD18, CD20, and CD90 positive with variable CD79a, CD1c and CD34 expression. All cell lines were tumorigenic in Nu/nu mice and were wild type for p53. Canine lymphoma cell lines serve as an important resource for translational lymphoma research.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. azwingen@ucdavis.edu
authors.forename: Allison L
authors.initials: AL
authors.lastname: Zwingenberger
authors.forename: William
authors.initials: W
authors.lastname: Vernau
authors.forename: Changying
authors.initials: C
authors.lastname: Shi
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yan
authors.forename: Xinbin
authors.initials: X
authors.lastname: Chen
authors.forename: Ira K
authors.initials: IK
authors.lastname: Gordon
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kent
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D045744:Cell Line, Tumor; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000662:veterinary*; D051379:Mice; D008819:Mice, Nude; D051736:Proto-Oncogene Proteins c-mdm2 / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D017252:CD3 Complex; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2