title: Down-regulation of heme oxygenase-1 by SVCV infection.
abstract: Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpio was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish.
authors.affiliation: College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China.
authors.forename: Junfa
authors.initials: J
authors.lastname: Yuan
authors.forename: Nian
authors.initials: N
authors.lastname: Su
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Zhengli
authors.initials: Z
authors.lastname: Shi
authors.forename: Lijuan
authors.initials: L
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002347:Carps / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D002460:Cell Line; D015536:Down-Regulation; D005393:Fish Diseases / Q000201:enzymology* / Q000276:immunology; D020869:Gene Expression Profiling; D051547:Heme Oxygenase-1 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D018353:Rhabdoviridae Infections / Q000201:enzymology / Q000276:immunology / Q000662:veterinary*; D016415:Sequence Alignment; D018116:Vesiculovirus / Q000276:immunology
chemical_list: D051547:Heme Oxygenase-1