title: Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system.
abstract: Exposure to interferon results in the rapid transcriptional induction of genes, many of which function to create an antiviral environment in potential host cells. For the majority of adenoviruses, replication is unaffected by the actions of interferon. It has previously been shown, using non-gastrointestinal cells, that the species F human adenoviruses are sensitive to the action of interferon. Here, we have developed an enterocyte-like cell-culture model to re-evaluate this question, and determined the effects of interferon on species F adenovirus during infection of gastrointestinal cells. We show that species F adenovirus type 40 is sensitive to the effects of interferon in gastrointestinal-like cells, which may help to explain its fastidious growth in culture.
authors.affiliation: Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sherwood
authors.affiliation: Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: King
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.
authors.forename: Sabine
authors.initials: S
authors.lastname: Tötemeyer
authors.affiliation: Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Connerton
authors.affiliation: Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mellits
mesh_terms: D000256:Adenoviridae / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity*; D000258:Adenovirus Infections, Human / Q000517:prevention & control*; D000998:Antiviral Agents / Q000494:pharmacology*; D018929:Cell Culture Techniques; D018890:Chemoprevention / Q000379:methods; D041981:Gastrointestinal Tract / Q000821:virology*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008962:Models, Theoretical
chemical_list: D000998:Antiviral Agents; D007372:Interferons