title: Toward systems biology in brown algae to explore acclimation and adaptation to the shore environment.
abstract: Brown algae belong to a phylogenetic lineage distantly related to land plants and animals. They are almost exclusively found in the intertidal zone, a harsh and frequently changing environment where organisms are submitted to marine and terrestrial constraints. In relation with their unique evolutionary history and their habitat, they feature several peculiarities, including at the level of their primary and secondary metabolism. The establishment of Ectocarpus siliculosus as a model organism for brown algae has represented a framework in which several omics techniques have been developed, in particular, to study the response of these organisms to abiotic stresses. With the recent publication of medium to high throughput profiling data, it is now possible to envision integrating observations at the cellular scale to apply systems biology approaches. As a first step, we propose a protocol focusing on integrating heterogeneous knowledge gained on brown algal metabolism. The resulting abstraction of the system will then help understanding how brown algae cope with changes in abiotic parameters within their unique habitat, and to decipher some of the mechanisms underlying their (1) acclimation and (2) adaptation, respectively consequences of (1) the behavior or (2) the topology of the system resulting from the integrative approach.
authors.affiliation: UPMC Univ Paris 6 , UMR 7139 Marine Plants and Biomolecules, Station Biologique, 29680 Roscoff, France. tonon@sb-roscoff.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Tonon
authors.forename: Damien
authors.initials: D
authors.lastname: Eveillard
authors.forename: Sylvain
authors.initials: S
authors.lastname: Prigent
authors.forename: Jérémie
authors.initials: J
authors.lastname: Bourdon
authors.forename: Philippe
authors.initials: P
authors.lastname: Potin
authors.forename: Catherine
authors.initials: C
authors.lastname: Boyen
authors.forename: Anne
authors.initials: A
authors.lastname: Siegel
mesh_terms: D000064:Acclimatization; D000222:Adaptation, Physiological; D005075:Biological Evolution; D017753:Ecosystem; D004777:Environment; D023281:Genomics; D000459:Phaeophyceae / Q000502:physiology*; D040901:Proteomics; D013312:Stress, Physiological; D049490:Systems Biology / Q000379:methods*