title: Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review).
abstract: There is strong evidence suggesting the presence of a genetic component             in the aetiology of multiple myeloma (MM). However no genetic risk factors have             been unequivocally established so far. To further our understanding of the genetic             determinants of MM risk, a promising strategy is to collect a large set of patients             in a consortium, as successfully done for other cancers. In this article, we review             the main findings in the genetic susceptibility and pharmacogenetics of MM and             present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch)             consortium in contributing to determine the role of genetic variation in pharmacogenetics             and in MM risk.
authors.affiliation: German Cancer Research Center, Genomic Epidemiology Group, Heidelberg, Germany. a.martino@dkfz-heidelberg.de
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martino
authors.forename: Juan
authors.initials: J
authors.lastname: Sainz
authors.forename: Gabriele
authors.initials: G
authors.lastname: Buda
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jamroziak
authors.forename: Rui Manuel
authors.initials: RM
authors.lastname: Reis
authors.forename: Ramón
authors.initials: R
authors.lastname: García-Sanz
authors.forename: Manuel
authors.initials: M
authors.lastname: Jurado
authors.forename: Rafael
authors.initials: R
authors.lastname: Ríos
authors.forename: Zofia
authors.initials: Z
authors.lastname: Szemraj-Rogucka
authors.forename: Herlander
authors.initials: H
authors.lastname: Marques
authors.forename: Fabienne
authors.initials: F
authors.lastname: Lesueur
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
authors.forename: Enrico
authors.initials: E
authors.lastname: Orciuolo
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Rossi
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
authors.forename: Daniele
authors.initials: D
authors.lastname: Campa
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
mesh_terms: D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods; D009101:Multiple Myeloma / Q000453:epidemiology* / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods; D012307:Risk Factors