title: Motion correction for myocardial T1 mapping using image registration with synthetic image estimation.
abstract: Quantification of myocardial T1 relaxation has potential value in the diagnosis of both ischemic and nonischemic cardiomyopathies. Image acquisition using the modified Look-Locker inversion recovery technique is clinically feasible for T1 mapping. However, respiratory motion limits its applicability and degrades the accuracy of T1 estimation. The robust registration of acquired inversion recovery images is particularly challenging due to the large changes in image contrast, especially for those images acquired near the signal null point of the inversion recovery and other inversion times for which there is little tissue contrast. In this article, we propose a novel motion correction algorithm. This approach is based on estimating synthetic images presenting contrast changes similar to the acquired images. The estimation of synthetic images is formulated as a variational energy minimization problem. Validation on a consecutive patient data cohort shows that this strategy can perform robust nonrigid registration to align inversion recovery images experiencing significant motion and lead to suppression of motion induced artifacts in the T1 map.
authors.affiliation: Siemens Corporate Research, Princeton, New Jersey, USA. hui-xue@siemens.com
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.forename: Saurabh
authors.initials: S
authors.lastname: Shah
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiser
authors.forename: Christoph
authors.initials: C
authors.lastname: Guetter
authors.forename: Arne
authors.initials: A
authors.lastname: Littmann
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Jolly
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arai
authors.forename: Sven
authors.initials: S
authors.lastname: Zuehlsdorff
authors.forename: Jens
authors.initials: J
authors.lastname: Guehring
authors.forename: Peter
authors.initials: P
authors.lastname: Kellman
mesh_terms: D000465:Algorithms; D016477:Artifacts; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008875:Middle Aged; D009038:Motion; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique