title: Mechanism of nitric oxide production in macrophages treated with medicinal mushroom extracts (review).
abstract: Nitric oxide (NO) is a gas with highly reactive radicals and is an important signal molecule in living organisms with diverse pathophysiological functions. Inducible NO synthase (iNOS) can be expressed in macrophages and is able to induce NO production. Studies have proposed that mushroom extracts can promote or inhibit NO production in macrophages through acting on iNOS, nuclear factor kappa B, and other signaling pathways. This article is dedicated to the mechanism of mushroom extracts affecting NO secretion in macrophages.
authors.affiliation: College of Life Science, South China Normal University, Guangzhou 510631, PR China.
authors.forename: Mian
authors.initials: M
authors.lastname: Huang
authors.forename: Xiaodeng
authors.initials: X
authors.lastname: Mei
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D045424:Complex Mixtures / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016328:NF-kappa B / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D045424:Complex Mixtures; D016328:NF-kappa B; D012333:RNA, Messenger; D009569:Nitric Oxide; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II