title: 23-valent pneumococcal vaccine failure in a patient who developed pneumonia: a case report.
abstract: We report a clinical failure of a pneumococcal vaccine in a patient who developed pneumococcal pneumonia. In 2008, an 85-year-old Italian woman was admitted to the Respiratory Disease Unit of a hospital in Southern Italy. The 23-valent pneumococcal vaccine had been administered to the patient 50 days earlier. The chest x-ray disclosed a right basal bronchopneumonic focus. Streptococcus Pneumoniae serotype 19A, a strain included in the 23-valent pneumococcal vaccine, was isolated from the sputum. There is a need for more efficacious conjugated vaccines covering the majority of the pneumococcal serotypes that cause serious illness in older children and adults worldwide.
authors.affiliation: Department of Biomedical Sciences, Hygiene Section, University of Bari Aldo Moro, Bari, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Tafuri
authors.forename: Domenico
authors.initials: D
authors.lastname: Martinelli
authors.forename: Anna
authors.initials: A
authors.lastname: Grimaldi
authors.forename: Annunziata
authors.initials: A
authors.lastname: Lopatriello
authors.forename: Vincenza
authors.initials: V
authors.lastname: Giorgio
authors.forename: Rosa
authors.initials: R
authors.lastname: Prato
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007558:Italy; D022242:Pneumococcal Vaccines / Q000009:adverse effects* / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis* / Q000382:microbiology* / Q000517:prevention & control; D013183:Sputum / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000276:immunology*; D017211:Treatment Failure
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines