title: Of mice and men: not ExAKTly the same?
abstract: The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrowth.
authors.affiliation: The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Wan
authors.forename: Morris J
authors.initials: MJ
authors.lastname: Birnbaum