title: Prediction of drug response and safety in clinical practice.
abstract: Many clinicians hoped that the completion of the Human Genome Project would result in "individualized drug therapy," i.e., determining the right medication at the right dose 100% of the time based upon the individual's genetics. The pharmacogenomic prediction of drug efficacy and safety has not become a reality due to continuing realization of the complexity dictating the human-drug interaction. New methods of metabolomics, proteomics, and transcriptomics that account for this complexity hold promise for translational researchers hoping to increase drug efficacy and decrease drug toxicity.
authors.affiliation: Rocky Mountain Poison and Drug Center, Denver, CO, USA. andrew.monte@ucdenver.edu
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Monte
authors.forename: Kennon J
authors.initials: KJ
authors.lastname: Heard
authors.forename: Vasilis
authors.initials: V
authors.lastname: Vasiliou
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D005838:Genotype; D006801:Humans; D055432:Metabolomics; D010597:Pharmacogenetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D017450:Receptors, Opioid, mu / Q000235:genetics
chemical_list: D017450:Receptors, Opioid, mu; D003577:Cytochrome P-450 Enzyme System