title: The effects of clenbuterol on cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.
abstract: OBJECTIVE
  To investigate the possible therapeutic effects of clenbuterol on cerebral vasospasm after subarachnoid hemorrhage (SAH) in rats.
  
  
  METHODS
  Eighteen male albino Wistar rats, each weighing 200-250 g, were randomized into three groups; Group 1 (Control group) (n = 6) having no SAH and no treatment; Group 2 (Sham group) (n = 6) having only SAH and Group 3 (Experimental group) (n = 6) having SAH treated with clenbuterol. Group 2 has been accepted as sham group to the experimental group. Experimental SAH was induced using a modified rat double hemorrhage model. Clenbuterol was administered twice daily in 12-hour intervals for three days at a dose of 0,1 mg/kg/day. The luminal diameter of the basilar artery was measured on each section with an optic micrometer by an experienced pathologist blinded to the groups.
  
  
  RESULTS
  Mean basilar artery diameters were found to be different between the three groups (p < 0.001). Mean value of Group 2 was significantly lower than that of Group 1 (p < 0.001). While mean value of Group 3 was significantly greater than that of Group 2 (p = 0.001), Groups1 and 3 were found to be similar (p = 0242).
  
  
  CONCLUSIONS
  Clenbuterol has favorable effects in the treatment of rat cerebral vasospasm (CVS). Further investigations are needed to evaluate both molecular effects and to find out effective treatment dose of clenbuterol on CVS.
authors.affiliation: Department of Neurosurgery, Pamukkale University Medical School, Denizli, Turkey.
authors.forename: Berk
authors.initials: B
authors.lastname: Benek
authors.forename: Feridun
authors.initials: F
authors.lastname: Acar
authors.forename: Bayram
authors.initials: B
authors.lastname: Cirak
authors.forename: Erdal
authors.initials: E
authors.lastname: Coskun
authors.forename: Levent
authors.initials: L
authors.lastname: Ozcakar
authors.forename: Nagihan
authors.initials: N
authors.lastname: Yalcin
authors.forename: Tuncer
authors.initials: T
authors.lastname: Suzer
authors.forename: Kadir
authors.initials: K
authors.lastname: Tahta
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002976:Clenbuterol / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy*; D020301:Vasospasm, Intracranial / Q000188:drug therapy*
chemical_list: D000318:Adrenergic beta-Agonists; D018696:Neuroprotective Agents; D002976:Clenbuterol