title: Dopaminergic modulation of the updating of stimulus-response episodes in Parkinson's disease.
abstract: Increasing evidence suggests that the control of retrieval of episodic feature bindings is modulated by the striatal dopaminergic pathway. The present study investigated whether this may reflect a contribution from the ventral or the dorsal part of the striatum. Along the lines of the overdose hypothesis in Parkinson's disease (PD), functions known to rely on the dorsal striatum are enhanced with dopaminergic medication, while operations relying on the ventral circuitry are impaired. We found that partial mismatches between present and previous stimulus-response relations are, compared to control participants, abnormally low OFF DA medication and normalized ON DA medication. The results suggest that the dorsal striatum, but not (or not so much) the ventral striatum, is driving the flexible control of retrieval of stimulus-response episodes.
authors.affiliation: Leiden University, Cognitive Psychology Unit & Leiden Institute for Brain and Cognition, Leiden, The Netherlands. colzato@fsw.leidenuniv.nl
authors.forename: Lorenza S
authors.initials: LS
authors.lastname: Colzato
authors.forename: Nelleke C
authors.initials: NC
authors.lastname: van Wouwe
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hommel
authors.forename: Sharon
authors.initials: S
authors.lastname: Zmigrod
authors.forename: K R
authors.initials: KR
authors.lastname: Ridderinkhof
authors.forename: S A
authors.initials: SA
authors.lastname: Wylie
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D059290:Dopaminergic Neurons / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology
chemical_list: D018491:Dopamine Agonists