title: Magnetic nanoparticles for magnetoresistance-based biodetection.
abstract: Magnetic nanoparticles (MNPs) have been studied widely as a powerful diagnostic probe and therapeutic agent for biomedical applications. In recent years, they are also found to be sensitive to magnetoresistive (MR) devices and MNP-MR biochips are predicted to be more affordable, portable and sensitive than the conventional optical detection methods. In this MNP-MR biochip design, MNP probes are required to have high magnetic moment, high susceptibility, and be target-specific. This review summarizes recent advances in chemical syntheses and functionalization of MNPs with controlled magnetic properties for sensitive MR detection and for bio-sensing applications.
authors.affiliation: Department of Chemistry, Brown University, Providence, RI 02912, USA.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Sun
authors.forename: Don
authors.initials: D
authors.lastname: Ho
authors.forename: Lise-Marie
authors.initials: LM
authors.lastname: Lacroix
authors.forename: John Q
authors.initials: JQ
authors.lastname: Xiao
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D058185:Magnetite Nanoparticles