title: Self-assembly process of peptide amphiphile worm-like micelles.
abstract: Peptide amphiphile molecules (PA) are remarkably versatile and useful as building blocks for construction of complex supramolecular structures in a bottom-up fashion. Worm-like micelles of PA have been demonstrated to have successful application to creation of synthetic extracellular matrix materials for tissue engineering and regenerative medicine. However, the pathway of the self-assembly process of the PA worm-like micelle has not been fully characterized or understood. This work analyzes the self-assembly process leading to worm-like micelle formation in our designed PA with small-angle neutron scattering and atomic force microscopy. The experimental results demonstrate the existence of transient spherical micelles in the early stage of the process and subsequent micelle chain elongation by attachment of spherical micelles to the end of growing cylindrical micelles to form worm-like micelles in a process mimicking chain-growth polymerization.
authors.affiliation: New Business Development, Asahi-Kasei Corporation, Jinbocho, Tokyo, Japan. shimada.td@om.asahi-kasei.co.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shimada
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Motokawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Koizumi
authors.forename: Matthew
authors.initials: M
authors.lastname: Tirrell
mesh_terms: D008823:Micelles; D018625:Microscopy, Atomic Force; D033363:Neutron Diffraction; D010455:Peptides / Q000737:chemistry*; D044968:Regenerative Medicine; D053838:Scattering, Small Angle; D023822:Tissue Engineering
chemical_list: D008823:Micelles; D010455:Peptides