title: Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance.
abstract: METHODS
  Several insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes. To examine whether the genetic variability at the IRS-2 gene locus was associated with the degree of insulin resistance and plasma fatty acid levels in metabolic syndrome (MetS) subjects.
  
  
  RESULTS
  Insulin sensitivity, insulin secretion, glucose effectiveness, plasma fatty acid composition and three IRS-2 tag-single nucleotide polymorphisms (SNPs) were determined in 452 MetS subjects. Among subjects with the lowest level of monounsaturated (MUFA) (below the median), the rs2289046 A/A genotype was associated with lower glucose effectiveness (p<0.038), higher fasting insulin concentrations (p<0.028) and higher HOMA IR (p<0.038) as compared to subjects carrying the minor G-allele (A/G and G/G). In contrast, among subjects with the highest level of MUFA (above the median), the A/A genotype was associated with lower fasting insulin concentrations and HOMA-IR, whereas individuals carrying the G allele and with the highest level of ω-3 polyunsaturated fatty acids (above the median) showed lower fasting insulin (p<0.01) and HOMA-IR (p<0.02) as compared with A/A subjects.
  
  
  CONCLUSIONS
  The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in MetS subjects.
authors.affiliation: Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion-CIBEROBN, Instituto de Salud Carlos, Cordoba, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Rios
authors.forename: Audrey C
authors.initials: AC
authors.lastname: Tierney
authors.forename: Hanne L
authors.initials: HL
authors.lastname: Gulseth
authors.forename: Christine M
authors.initials: CM
authors.lastname: Williams
authors.forename: Brita
authors.initials: B
authors.lastname: Karlström
authors.forename: Beata
authors.initials: B
authors.lastname: Kieć-Wilk
authors.forename: Ellen E
authors.initials: EE
authors.lastname: Blaak
authors.forename: Olfa
authors.initials: O
authors.lastname: Helal
authors.forename: Wim H M
authors.initials: WH
authors.lastname: Saris
authors.forename: Catherine
authors.initials: C
authors.lastname: Defoort
authors.forename: Christian A
authors.initials: CA
authors.lastname: Drevon
authors.forename: Julie A
authors.initials: JA
authors.lastname: Lovegrove
authors.forename: Aldona
authors.initials: A
authors.lastname: Dembinska-Kieć
authors.forename: Ulf
authors.initials: U
authors.lastname: Riserus
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D000328:Adult; D000368:Aged; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; C526297:IRS2 protein, human; D055504:Insulin Receptor Substrate Proteins