title: Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients.
abstract: BACKGROUND
  Several polymorphisms in FK506 Binding Protein gene (FKBP5) and a history of child abuse have been shown to be associated with an increased risk for posttraumatic stress disorder (PTSD). It has also been demonstrated that the same polymorphisms of FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. However, there are only limited numbers of studies replicating the polymorphisms as vulnerability factors for the development of mental illnesses, such as PTSD and depression after stressful life event, especially with a specific incidence, such as kidney transplant surgery.
  
  
  METHODS
  A retrospective analysis was conducted using the electronic medical records of 131 adult kidney transplant recipients. Depression severity after kidney transplantation was measured by PHQ-9, and stored blood was genotyped for variants in the Serotonin Transporter (SLC6A4), Brain-Derived Neurotrophic Factor, Catecholamine-O-Methyltransferase, Corticotropin-Releasing Hormone Receptor, and FKBP5 genes. Spearman correlations were used to test for association between genetic variants and depression severity.
  
  
  RESULTS
  The rare alleles at three out of four SNPs in FKBP5 (rs1360780, rs9296158, and rs9470080) were associated with increased PHQ-9 scores (P<.05), whereas the last FKBP5 SNP (rs3800373) showed a trend of association (P<.10). All four FKBP5 SNPs are in strong linkage disequilibrium. Although in a subgroup of Caucasian non-Hispanic subjects the association was not statistically significant, the direction of association was consistent with that observed in the entire sample as well as in previous studies. Polymorphisms in genes other than FKBP5 were not associated with PHQ-9 scores.
  
  
  CONCLUSIONS
  Polymorphisms in FKBP5 may be associated with higher depression scores in kidney transplant recipients.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA. shinozaki.gen@mayo.edu
authors.forename: Gen
authors.initials: G
authors.lastname: Shinozaki
authors.forename: Sheila
authors.initials: S
authors.lastname: Jowsey
authors.forename: Hatem
authors.initials: H
authors.lastname: Amer
authors.forename: Joanna
authors.initials: J
authors.lastname: Biernacka
authors.forename: Colin
authors.initials: C
authors.lastname: Colby
authors.forename: Denise
authors.initials: D
authors.lastname: Walker
authors.forename: John
authors.initials: J
authors.lastname: Black
authors.forename: James
authors.initials: J
authors.lastname: Rundell
authors.forename: Mark
authors.initials: M
authors.lastname: Stegall
authors.forename: David A
authors.initials: DA
authors.lastname: Mrazek
mesh_terms: D000483:Alleles; D003863:Depression / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016030:Kidney Transplantation / Q000523:psychology*; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D022021:Tacrolimus Binding Proteins / Q000235:genetics*
chemical_list: D022021:Tacrolimus Binding Proteins