title: Apelin in acute myocardial infarction and heart failure induced by ischemia.
abstract: Apelin is a recently isolated novel endogenous ligand for the angiotensin-like 1 receptor (APJ). Initial experiments in animal models indicate that the cardiovascular system is the main target of the apelin-APJ system. Apelin plays an opposite role to the renin-angiotensin-aldosterone system as a compensatory mechanism. It is reduced in patients with heart failure, also of ischemic origin. However, only animal studies concern the role of the apelin-APJ system in myocardial ischemia. Less is known about the function of this adipokine in an acute phase of myocardial infarction in human. The apelin-APJ system could perhaps be involved in myocardial protection during acute myocardial ischemia. In the current review we have summarized recent data concerning the role of apelin in acute myocardial infarction and heart failure induced by ischemia.
authors.affiliation: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. agnieszka.tycinska@gmail.com
authors.forename: Agnieszka M
authors.initials: AM
authors.lastname: Tycinska
authors.forename: Anna
authors.initials: A
authors.lastname: Lisowska
authors.forename: Wlodzimierz J
authors.initials: WJ
authors.lastname: Musial
authors.forename: Bozena
authors.initials: B
authors.lastname: Sobkowicz
mesh_terms: D000208:Acute Disease; D000818:Animals; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D009203:Myocardial Infarction / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000150:complications*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins