title: Purinergic signaling in healthy and diseased skin.
abstract: Adenosine 5'-triphosphate and adenosine receptors have been identified in adult and fetal keratinocytes, fibroblasts, melanocytes, mast cells, Langerhans cells, and Meissner's corpuscles, as well as in hair follicles, sweat glands, and smooth muscle and endothelial cells of skin vessels. Purinergic signaling is involved in skin pathology, including inflammation, wound healing, pain, psoriasis, scleroderma, warts, and skin cancer.
authors.affiliation: Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK. g.burnstock@ucl.ac.uk
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Knight
authors.forename: Aina V H
authors.initials: AV
authors.lastname: Greig
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D058913:Purinergic Agonists / Q000494:pharmacology; D058914:Purinergic Antagonists / Q000494:pharmacology; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D058913:Purinergic Agonists; D058914:Purinergic Antagonists; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate