title: βhCG and PAPP-A in first trimester: predictive factors for preeclampsia?
abstract: OBJECTIVE
  The aim of our study was to investigate a possible correlation between the expression of the placenta-secreted hormones, β-subunit of human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A), during the first trimester screening and the development of preeclampsia.
  
  
  METHODS
  A total of 155 patients between 11 + 0 and 13 + 6 weeks of gestation were enrolled in this study. PAPP-A and βhCG levels were measured using the KRYPTOR® system.
  
  
  RESULTS
  The serum levels of βhCG were significantly higher in pregnancies which subsequently developed preeclampsia. The PAPP-A concentration did not differ significantly in pregnancies complicated by preeclampsia than in uncomplicated pregnancies.
  
  
  CONCLUSIONS
  These results might contribute to developing new tests in the prediction of preeclampsia.
authors.affiliation: Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany. barbara.mikat@uk-essen.de
authors.forename: Barbara
authors.initials: B
authors.lastname: Mikat
authors.forename: Anna
authors.initials: A
authors.lastname: Zeller
authors.forename: André
authors.initials: A
authors.lastname: Scherag
authors.forename: Karla
authors.initials: K
authors.lastname: Drommelschmidt
authors.forename: Rainer
authors.initials: R
authors.lastname: Kimmig
authors.forename: Markus
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A