title: Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon.
abstract: In the present study, we investigate the mucoadhesive characteristics and release of the anticancer agent curcumin, contained in chitosan nanoparticles (CS-NPs). Such a system has potential therapeutic benefits in the treatment of colon cancer through prolonged retention and delivery. The CS-NPs were ionically gelled with tripolyphosphate (TPP) and registered an isoelectric pH of 6.2 (z-average diameter of 214 nm ± 1.0 nm). pH variations around the isoelectric point caused a reduction in CS-NPs electrical charge which correspondingly increased the z-average due to agglomeration. Curcumin release from CS-NPs was slowest at chitosan to TPP weight ratio of 3:1, with a significant retention (36%) at the end of 6 h. Adsorption isotherms of mucin on CS-NPs fitted both the Freundlich and Langmuir models, suggesting a monolayer-limited adsorption on heterogeneous sites with varied affinities. Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as π-π interactions between the phenolic moieties of curcumin and mucin.
authors.affiliation: School of Pharmacy, The University of Nottingham, Malaysia Campus, Jalan Broga, Semenyih, Malaysia.
authors.forename: Lay Hong
authors.initials: LH
authors.lastname: Chuah
authors.forename: Nashiru
authors.initials: N
authors.lastname: Billa
authors.forename: Clive J
authors.initials: CJ
authors.lastname: Roberts
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Burley
authors.forename: Sivakumar
authors.initials: S
authors.lastname: Manickam
mesh_terms: D000269:Adhesives / Q000008:administration & dosage / Q000138:chemical synthesis*; D000818:Animals; D048271:Chitosan / Q000008:administration & dosage* / Q000138:chemical synthesis; D003106:Colon / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage* / Q000138:chemical synthesis; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis; D016503:Drug Delivery Systems / Q000379:methods*; D007413:Intestinal Mucosa / Q000187:drug effects; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D013552:Swine
chemical_list: D000269:Adhesives; D004337:Drug Carriers; D048271:Chitosan; D003474:Curcumin