title: Hepatoprotective, cardioprotective, and renal-protective effects of organic and conventional grapevine leaf extracts on Wistar rat tissues.
abstract: The purpose of this study was to evaluate the beneficial effects of organic and conventional grapevine (Vitis labrusca L.) leaf extracts in reducing hydrogen peroxide-induced stress in the liver, heart and kidney of Wistar rats by measuring lipids and proteins damages (carbonyl assay), as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The preincubation with 5 mg/mL of organic and conventional grapevine (Vitis labrusca L.) leaf extracts prevented both lipids and proteins oxidative damages in all tissues analyzed. The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H(2)O(2). The conventional extract was able to restore only the catalase activity in liver and heart tissues. The beneficial effects of the V labrusca leaf extract shown in this study could probably be important for formulating dietary supplements, as well as for developing new ingredients with improved antioxidant properties from other plant sources.
authors.affiliation: Laboratório de Estresse Oxidativo e Antioxidantes, Instituto de Biotecnologia, Universidade de Caxias do Sul, RS, Brasil.
authors.forename: Lívia S
authors.initials: LS
authors.lastname: Oliboni
authors.forename: Caroline
authors.initials: C
authors.lastname: Dani
authors.forename: Cláudia
authors.initials: C
authors.lastname: Funchal
authors.forename: João A
authors.initials: JA
authors.lastname: Henriques
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000032:analysis / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D020011:Protective Agents; D011506:Proteins; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase