title: Evaluation of in vivo and in vitro biological activities of different extracts of Cuscuta arvensis.
abstract: In the present study, the potential effects of extracts from the whole plant of Cuscuta arvensis were studied in mice using the carrageenan-induced hind paw edema model for antiinflammatory activity and the p-benzoquinone-induced writhing reflex for the assessment of antinociceptive activity. In order to obtain the extracts, the whole plant of C. arvensis was extracted with different solvents such as n-hexane, dichloromethane, ethyl acetate, methanol and distilled water. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The methanolic and water extracts inhibited the carrageenan-induced paw edema and p-benzoquinone-induced writhing reflex, whereas the other extracts showed only mild inhibitory antinociceptive and antiinflammatory activities in these in vivo models. Additionally, the methanol and ethyl acetate extracts had higher scavenging ability then the non polar extracts.
authors.affiliation: Department of Pharmocognosy, Faculty of Pharmacy, Gazi University, 06330 Etiler-Ankara, Turkey. ukoca@gazi.edu.tr
authors.forename: Ufuk
authors.initials: U
authors.lastname: Koca
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli-Akkol
authors.forename: Nazim
authors.initials: N
authors.lastname: Sekeroglu
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D034182:Cuscuta / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts