title: [Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate cancer].
abstract: OBJECTIVE
  To evaluate the correlation of the single nucleotide polymorphisms (SNPs) of the CYP1A2 gene with the stages and grades of prostate cancer (PCa).
  
  
  METHODS
  We conducted gene sequencing of the rs2069514-3859 (A > G) and rs2069525-1707 (C >T) alleles in the CYP1A2 gene in 253 patients with benign prostatic hyperplasia (BPH) and 206 patients with PCa treated by castration therapy, and statistically analyzed their correlations with the genotypes, stages and grades of prostate cancer.
  
  
  RESULTS
  The incidences of the 2 CYP1A2 SNPs showed no significant difference between the BPH and the castrated PCa patients (P > 0.05), and their genotypes were not correlated with the stages of PCa (P > 0.05). The Gleason scores were mostly <7 in the PCa patients with genotypes containing C in the rs2069525-1707 (C > T) allele (P = 0.030, OR = 4.658, 95% CI: 1.222 - 17.754).
  
  
  CONCLUSIONS
  SNPs of the CYP1A2 gene may have some correlations with the pathologic stages of PCa, but their mechanisms and clinical significance need to be further confirmed.
authors.affiliation: Department of Urology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Ge
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Gao
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D019388:Cytochrome P-450 CYP1A2