title: Diseases in a dish: modeling human genetic disorders using induced pluripotent cells.
abstract: The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.
authors.affiliation: Centre of Regenerative Medicine in Barcelona, Barcelona, Spain.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Tiscornia
authors.forename: Erica Lorenzo
authors.initials: EL
authors.lastname: Vivas
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisúa Belmonte
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000473:pathology*; D015894:Genome, Human; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D010641:Phenotype