title: Evaluation of endostatin and EGF serum levels in patients with gastric cancer.
abstract: THE AIM OF THE STUDY was to assess angiogenesis markers - endostatin and endothelial growth factor (EGF) as markers of detection of gastric carcinoma. MATERIAL AND METHODS. The study involved 20 patients with colorectal cancer (10 women, 10 men) aged 35 - 75 years, mean age = 55 years ± 11.2 who referred to the 2nd Department of General Surgery, Medical University in Lublin between June 2008 and June 2009. The control group comprised 10 volunteers (6 women, 4 men) who underwent upper gastrointestinal (GI) endoscopy due to the reflux disease and in whom gastric cancer was not diagnosed. RESULTS. The mean endostatin concentration in controls was 5.21 ng/mL ± 1.37. Mean concentrations in patients with gastric cancer were higher than those in controls - 5.91 ng/mL ± 1.5. The difference was not statistically significant (p= 0.714). The EGF concentration in the control group was 28.19 pg/mL ± 12.94. EGF concentrations in patients with gastric cancer were higher compared to the control group - 28.8 pg/mL ± 12.63. The difference was not statistically significant (p= 0.85). The mean concentration of endostatin before the operation was 5.91 ng/mL ± 1.5 and after surgery was 5.33 ng/mL ± 2.01, the difference was not statistically significant. CONCLUSIONS. Blood endostatin and EGF quantitative determinations probably is not useful for detection of gastric carcinoma and effectiveness of treatment.
authors.affiliation: 2nd Department of General Surgery, Medical University in Lublin.
authors.forename: Wioletta
authors.initials: W
authors.lastname: Masiak
authors.forename: Anna
authors.initials: A
authors.lastname: Szponar
authors.forename: Grażyna
authors.initials: G
authors.lastname: Chodorowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dąbrowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pedowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wallner
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D043169:Endostatins / Q000097:blood*; D016228:Endothelial Growth Factors / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D043169:Endostatins; D016228:Endothelial Growth Factors