title: Diffusion-weighted magnetic resonance imaging detects local recurrence after radical prostatectomy: initial experience.
abstract: Current conventional cross-sectional imaging techniques, such as contrast-enhanced computed tomography and magnetic resonance imaging (MRI), are largely inaccurate in detecting local recurrence after radical prostatectomy. We report on five patients with biochemical recurrence after radical retropubic prostatectomy and pelvic lymph node dissection for whom local recurrence could only be detected with diffusion-weighted (DW) MRI. Prior to DW-MRI, all patients had negative digital rectal examinations, negative or equivocal conventional cross-sectional imaging, and negative bone scans. All suspicious lesions on DW-MRI imaging were histologically proved to be local recurrences of prostate cancer after either transrectal ultrasound-guided or transurethral biopsy. These results should encourage other centres to test our findings.
authors.affiliation: Department of Urology, University of Bern, Inselspital, Bern, Switzerland.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Giannarini
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Nguyen
authors.forename: George N
authors.initials: GN
authors.lastname: Thalmann
authors.forename: Harriet C
authors.initials: HC
authors.lastname: Thoeny
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000601:surgery*
chemical_list: D017430:Prostate-Specific Antigen