title: Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats.
abstract: Pneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits. However, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. In this context, we evaluated depressive-like parameters; corticosterone and ACTH levels in pneumococcal meningitis surviving rats. Wistar rats underwent a magna cistern tap receiving either 10 μL sterile saline or a Streptococcus pneumoniae suspension at the concentration of 5 × 10(9) cfu/mL. After 3 days of meningitis induction procedure, the animals were treated with imipramine at 10 mg/kg or saline for 14 days (3rd-17th day). The consumption of sweet food was measured for 7 days (10th-17th day). The meningitis group decreased the sucrose intake and increased the levels of corticosterone and ACTH levels in the serum and TNF-α in the cortex; however, the treatment with imipramine reverted the reduction of sweet food consumption, normalized hormonal levels and TNF-α in the cortex. Our results supported the hypothesis that the pneumococcal meningitis surviving rats showed depressive-like behavior and alterations in the hypothalamus-pituitary-adrenal axis.
authors.affiliation: Laboratório de Microbiologia Experimental e Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil. tba@unesc.net
authors.forename: Tatiana
authors.initials: T
authors.lastname: Barichello
authors.forename: Graziele
authors.initials: G
authors.lastname: Milioli
authors.forename: Jaqueline S
authors.initials: JS
authors.lastname: Generoso
authors.forename: Andreza L
authors.initials: AL
authors.lastname: Cipriano
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Costa
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Moreira
authors.forename: Márcia Carvalho
authors.initials: MC
authors.lastname: Vilela
authors.forename: Clarissa M
authors.initials: CM
authors.lastname: Comim
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D059445:Anhedonia; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001835:Body Weight / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology* / Q000523:psychology; D004435:Eating / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008586:Meningitis, Pneumococcal / Q000150:complications* / Q000523:psychology; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013296:Streptococcus pneumoniae / Q000254:growth & development; D017741:Survivors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000929:Antidepressive Agents, Tricyclic; D014409:Tumor Necrosis Factor-alpha; D000324:Adrenocorticotropic Hormone; D007099:Imipramine; D003345:Corticosterone