title: Antioxidant activity of some lichen metabolites.
abstract: Antioxidant activity of several classes of lichen metabolites were assessed in the in vitro superoxide radical (SOR), nitric oxide radical and 2,2-diphenyl-1-picrylhydrazil radical scavenging assays. The despsides sekikaic acid and lecanoric acid showed promising antioxidant activity in SOR assay with IC₅₀ values of 82.0 ± 0.3 µmol and 91.5 ± 2.1 µmol, respectively, while the depsidone lobaric acid exhibited an IC₅₀ value of 97.9 ± 1.6 µmol, all relative to the standard, propyl gallate (IC₅₀ = 106.0 ± 1.7 µmol). One of the most abundant mononuclear phenolic compounds, methyl-β-orcinol carboxylate was found to be a potent NO scavenger (IC₅₀ = 84.7 ± 0.1 µmol), compared to the standard rutin (IC₅₀ = 86.8 ± 1.9 µmol).
authors.affiliation: Department of Chemistry, University of Peradeniya, Peradeniya 20400, Sri Lanka.
authors.forename: Vinitha M
authors.initials: VM
authors.lastname: Thadhani
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.forename: Iman
authors.initials: I
authors.lastname: Omar
authors.forename: Hina
authors.initials: H
authors.lastname: Siddique
authors.forename: Veranja
authors.initials: V
authors.lastname: Karunaratne
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D005591:Chemical Fractionation; D045424:Complex Mixtures / Q000302:isolation & purification / Q000494:pharmacology*; D053630:Depsides / Q000302:isolation & purification / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010851:Picrates / Q000378:metabolism; D012459:Salicylates / Q000302:isolation & purification / Q000494:pharmacology; D013045:Species Specificity; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D045424:Complex Mixtures; D053630:Depsides; D016166:Free Radical Scavengers; D007783:Lactones; D010851:Picrates; D012459:Salicylates; D013481:Superoxides; D009569:Nitric Oxide; C008263:lecanoric acid; C104417:lobaric acid; C004931:1,1-diphenyl-2-picrylhydrazyl