title: Biologically active polymersomes from amphiphilic glycopeptides.
abstract: Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Colin
authors.initials: C
authors.lastname: Bonduelle
authors.forename: Julie
authors.initials: J
authors.lastname: Thévenot
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lecommandoux
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
mesh_terms: D057930:Click Chemistry; D006023:Glycoproteins / Q000737:chemistry*; D006031:Glycosylation; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D011108:Polymers