title: Cytocompatible encapsulation of individual Chlorella cells within titanium dioxide shells by a designed catalytic peptide.
abstract: The individual encapsulation of living cells has a great impact on the areas of single cell-based sensors and devices as well as fundamental studies in single cell-based biology. In this work, living  Chlorella  cells were encapsulated individually with abiological, functionalizable TiO(2), by a designed catalytic peptide that was inspired by biosilicification of diatoms in nature. The bioinspired cytocompatible reaction conditions allowed the encapsulated  Chlorella  cells to maintain their viability and original shapes. After formation of the TiO(2) shells, the shells were postfunctionalized by using catechol chemistry. Our work suggests a bioinspired approach to the interfacing of individual living cells with abiological materials in a controlled manner.
authors.affiliation: Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701, Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Yang
authors.forename: Eun Hyea
authors.initials: EH
authors.lastname: Ko
authors.forename: Insung S
authors.initials: IS
authors.lastname: Choi
mesh_terms: D000595:Amino Acid Sequence; D055162:Biocatalysis; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D032701:Biomimetics / Q000379:methods*; D002214:Capsules; D002470:Cell Survival / Q000187:drug effects; D002708:Chlorella / Q000166:cytology*; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D010455:Peptides; C009495:titanium dioxide; D014025:Titanium