title: Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells.
abstract: Naringenin has been shown to display various biological effects such as             antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin             inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin             suppresses the activity of acetylcholinesterase. They all belong to flavanone             which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer             activities of flavanone derivatives have rarely been reported, we examined the             effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results             suggest that flavanone derivatives control the expression of cell cycle regulatory             proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity             of HCT116 cells. In addition, in order to design flavanone derivatives that show             better anticancer activity, structure-activity relationships were examined.
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, Konkuk University,                     MoleNBio, Seoul 143-701, Republic of Korea.
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Woo
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Jiye
authors.initials: J
authors.lastname: Hyun
authors.forename: Sung Dae
authors.initials: SD
authors.lastname: Lee
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D015179:Colorectal Neoplasms / Q000378:metabolism*; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship; D014410:Tumor Stem Cell Assay
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones