title: Interleukin 1 beta -511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis.
abstract: One previous meta-analysis found no evidence that interleukin 1 beta (IL-1β) -511 gene polymorphism was associated with febrile seizures (FS) by pooling a limited number of studies. However, it is necessary for the meta-analysis to reevaluate the relationship with more recent findings. Electronic databases were systematically searched for studies published before June 2011. Pooled odds ratios (OR) and 95% confidence interval (CI) were estimated by means of a genetic model free approach. Subgroup and sensitivity analyses were also performed. All statistical analyses were conducted using Stata 9.0. A total of eight studies, 728 FS cases and 1,223 controls, met the selection criteria. The results show a significant association between IL-1β -511 C/T gene polymorphism and FS (recessive genetic model TT vs. CC + CT: OR = 1.361, 95% CI: 1.065-1.738, P = 0.014). Subgroup analyses show a significant association in Asia (OR = 1.394, 95% CI: 1.005-1.935, P = 0.047), but not in Europe (OR = 1.387, 95% CI: 0.750-2.565, P = 0.298). IL-1β -511 C/T gene polymorphism may play a role in susceptibility to FS, especially in Asia. Geographic differences may be a critical factor in the risk of FS.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, China.
authors.forename: Zhen-Qiang
authors.initials: ZQ
authors.lastname: Wu
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Ye-Huan
authors.initials: YH
authors.lastname: Sun
authors.forename: Cizao
authors.initials: C
authors.lastname: Ren
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Jiang
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Lv
mesh_terms: D030541:Databases, Genetic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D003294:Seizures, Febrile / Q000235:genetics*
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta