title: Estimation of instantaneous secretory rates and intrinsic characteristics of luteinizing hormone secretion in women with Kallmann syndrome before and after estriol administration.
abstract: Three Kallmann syndrome (KS) patients were examined to assess characteristics of LH response to GnRH bolus, with and without GnRH sensitization using Instantaneous Secretory Rate (ISR) computation before and after estriol treatment (60 days, 2 mg/day). Six healthy women were enrolled as controls and underwent GnRH bolus during the early follicular phase (days 3-5 of the menstrual cycle). After estriol treatment, the KS patients showed a higher LH response to GnRH bolus and similar LH pulse duration to healthy controls. These data support the hypothesis that the administration of weak estrogen improves LH response to GnRH in hypogonadotropic women with KS.
authors.affiliation: Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Italy. algen@unimo.it
authors.forename: Alessandro D
authors.initials: AD
authors.lastname: Genazzani
authors.forename: Susanna
authors.initials: S
authors.lastname: Santagni
authors.forename: Elisa
authors.initials: E
authors.lastname: Chierchia
authors.forename: Erika
authors.initials: E
authors.lastname: Rattighieri
authors.forename: Annalisa
authors.initials: A
authors.lastname: Campedelli
authors.forename: Alessia
authors.initials: A
authors.lastname: Prati
authors.forename: Federica
authors.initials: F
authors.lastname: Ricchieri
authors.forename: Tommaso
authors.initials: T
authors.lastname: Simoncini
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D004964:Estriol / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D017436:Kallmann Syndrome / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D004964:Estriol