title: Biomarker responses and genotoxicity in the mud snail (Bullacta exarata) as indicators of coastal contamination.
abstract: In the present study different biomarker responses and genotoxicity were determined in wild mud snails (Bullacta exarata) collected from 3 sampling sites in Bohai Bay in northeastern China, which is a region that is under considerable anthropogenic influence. Significant spatial variability of superoxide dismutase (SOD) and metallothionein (MT)-like proteins were recorded, while glutathione transferase (GST), catalase (CAT), and vitellin-like proteins (Vn's) were not observed. Furthermore, genomic DNA that was amplified with 4 fluorescence-labeled primer pairs showed variable genetic distances among the 3 wild mud snail populations found in Bohai Bay, which may be correlated with differences in the types of environmental genotoxicants, such as heavy metals and polycyclic aromatic hydrocarbons. This multi-biomarker approach provided an improved understanding of the potential toxicological impact of contaminated sediments on benthic organisms.
authors.affiliation: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy for Environmental Sciences, Beijing 100012, China. anlh@craes.org.cn
authors.forename: Li-hui
authors.initials: LH
authors.lastname: An
authors.forename: Bing-hui
authors.initials: BH
authors.lastname: Zheng
authors.forename: Li-jing
authors.initials: LJ
authors.lastname: Wang
authors.forename: Yan-Qiang
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Xing-ru
authors.initials: XR
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Lei
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D002681:China; D004249:DNA Damage / Q000187:drug effects; D004784:Environmental Monitoring; D014644:Genetic Variation; D019015:Geologic Sediments / Q000737:chemistry; D008668:Metallothionein / Q000378:metabolism; D019216:Metals, Heavy / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D012908:Snails / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical
chemical_list: D015415:Biomarkers; D019216:Metals, Heavy; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D008668:Metallothionein; D013482:Superoxide Dismutase