title: Protective effect of selenium against mercury-induced toxicity on hematological and biochemical parameters of Oreochromis niloticus.
abstract: In this study, to identify mercury (Hg) toxicity and whether selenium (Se) has any role in alleviation of this toxicity, it was investigated the changes in hematological and serum biochemical parameters of Oreochromis niloticus. Fish were exposed to 0.01 and 0.1 mg/L Hg and 0.01 mg/L Hg + 0.1 mg/L Se and 0.1 mg/L Hg + 1.0 mg/L Se for 7 and 14 days. The exposure of O. niloticus to Hg alone resulted in decreases in red blood cell, white blood cell, hemoglobin, hematocrit values, and cholinesterase activity while it increased in alanine aminotransferase and aspartate aminotransferase activities and cortisol and glucose levels. Se, in combination with Hg, partially or totally caused an alleviation for the toxic effect of Hg on the above mentioned hematological and biochemical parameters. The results of our study showed that Se has a protective effect against toxicity induced by Hg.
authors.affiliation: Department of Biology, Faculty of Science and Letters, Kilis 7 Aralik University, 79100 Kilis, Turkey. hcogun@kilis.edu.tr
authors.forename: Hikmet Y
authors.initials: HY
authors.lastname: Cogun
authors.forename: Ozgür
authors.initials: O
authors.lastname: Fırat
authors.forename: Ozge
authors.initials: O
authors.lastname: Fırat
authors.forename: Tüzin A
authors.initials: TA
authors.lastname: Yüzereroǧlu
authors.forename: Gülbin
authors.initials: G
authors.lastname: Gök
authors.forename: Ferit
authors.initials: F
authors.lastname: Kargin
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Kötemen
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D002802:Cholinesterases / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D007962:Leukocytes / Q000187:drug effects; D008628:Mercury / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D012643:Selenium / Q000494:pharmacology*; D017210:Tilapia / Q000097:blood*; D014873:Water Pollutants / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D020011:Protective Agents; D014873:Water Pollutants; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases; D008628:Mercury; D012643:Selenium; D006854:Hydrocortisone