title: The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study.
abstract: BACKGROUND
  The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2-) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.
  
  
  METHODS
  Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions.
  
  
  RESULTS
  Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p < 0.05).
  
  
  CONCLUSIONS
  Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.
authors.affiliation: Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília-UCB, Brasília-DF, Brazil.
authors.forename: Hugo A P
authors.initials: HA
authors.lastname: Santana
authors.forename: Sérgio R
authors.initials: SR
authors.lastname: Moreira
authors.forename: Willson B
authors.initials: WB
authors.lastname: Neto
authors.forename: Carla B
authors.initials: CB
authors.lastname: Silva
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Sales
authors.forename: Vanessa N
authors.initials: VN
authors.lastname: Oliveira
authors.forename: Ricardo Y
authors.initials: RY
authors.lastname: Asano
authors.forename: Foued S
authors.initials: FS
authors.lastname: Espíndola
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
authors.forename: Carmen S G
authors.initials: CS
authors.lastname: Campbell
authors.forename: Herbert G
authors.initials: HG
authors.lastname: Simões
mesh_terms: D000368:Aged; D000483:Alleles; D001794:Blood Pressure / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D005082:Physical Exertion / Q000235:genetics*; D012463:Saliva / Q000737:chemistry; D013997:Time Factors
chemical_list: D009573:Nitrites; D009569:Nitric Oxide; D007703:Peptidyl-Dipeptidase A