title: [Overview on omega-3 polyunsaturated fatty acids and heart failure].
abstract: Despite aggressive pharmacotherapy, heart failure is still clinical problem. Current therapies improve clinical symptoms and slow progression to heart failure, but overall the prognosis remains poor. Evidence from epidemiological, clinical and experimental studies indicates a beneficial role of the omega-3 polyunsaturated fatty acids (omega-3 PUFA) found in fish oils in the prevention and management of heart failure. Although the mechanisms is still unclear, clinical and animals studies indicate that the benefits of omega-3 PUFA may be attributed to a number of distinct biological effects on lipoprotein metabolism, inflammation response and mitochondrial function. This review summarise the data related to use of omega-3 PUFA supplementation as a potential treatment for heart failure and discussed possible mechanism of action.
authors.affiliation: Zakład Fizjologii Klinicznej, Centrum Medyczne Kształcenia Podyplomowego, Warszawa. mondud@gmail.com
authors.forename: Monika K
authors.initials: MK
authors.lastname: Duda
authors.forename: Karen M
authors.initials: KM
authors.lastname: O'Shea
authors.forename: William C
authors.initials: WC
authors.lastname: Stanley
mesh_terms: D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage*; D006333:Heart Failure / Q000178:diet therapy* / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008074:Lipoproteins