title: [Experimental study on the potential role of BME-10X collagen/hydroxyapatite bone graft in periodontal tissue regeneration of beagle].
abstract: OBJECTIVE
  To evaluate the potential role of BME-10X collagen/hydroxyapatite (HA) bone graft in periodontal tissue regeneration.
  
  
  METHODS
  Four 18 months old male beagles in the experiment were treated with non-surgical periodontal therapy. At the sites of mandibular 3rd and 4th premolars at the time of dogs were treated with non-surgical periodontal therapy one week later, the teeth with the same name in the same jaw were selected to the experimental group (T group) or the control group (C group) at random. The defects in T group were filled with BME-10X collagen/HA bone graft while the defects in C group were filled with nothing. The dogs were sacrificed in twelve weeks and analyzed by histopathology.
  
  
  RESULTS
  The defects in T group got more tissue regeneration compared with the defects in C group. The height of new bone (NB) was (3.01 +/- 0.14) mm in T group versus (1.32 +/- 0.11) mm in C group (P < 0.05). The height of new periodontal ligament (NP) was (3.12 +/- 0.19) mm in T group versus (1.35 +/- 0.12) mm in C group (P < 0.05). The height of new cementum (NC) was (3.30 +/- 0.15) mm in T group versus (2.70 +/- 0.12) mm in C group (P > 0.05). The new tissue guided by the bone graft was the same as the normal tissue in histopathology analysis.
  
  
  CONCLUSIONS
  The results of the study suggest that BME-10X collagen/HA bone graft is a good bone graft for periodontal tissue regeneration.
authors.affiliation: Dept. of Periodontology, Institute and Hospital of Stomatology, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Wenlei
authors.initials: W
authors.lastname: Wu
authors.forename: Qiqing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Huang
authors.forename: Xianghua
authors.initials: X
authors.lastname: Chen
mesh_terms: D016301:Alveolar Bone Loss; D000818:Animals; D001641:Bicuspid; D001861:Bone Regeneration; D016025:Bone Transplantation; D003094:Collagen; D003739:Dental Cementum; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D006882:Hydroxyapatites; D008297:Male; D008334:Mandible; D010513:Periodontal Ligament; D012038:Regeneration
chemical_list: D006882:Hydroxyapatites; D003094:Collagen