title: [Clinicoimmunological monitoring of therapy in patients with associated forms of yersiniosis].
abstract: Characteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant interferon in the patients with the viral and bacterial association of the disease (yersiniosis + hepatitis A) and initial disbalance of the serum cytokines was estimated. Dependence of the interferon clinicolaboratory efficacy on the initial levels of serum y-interferon, IL2 and IIA, promoting shorter terms of hyperthermia, diarrhea syndrome and cytolysis syndrome was shown. It allowed to optimize the scheme of the pathogenetic therapy of Yersinia mixed infection.
authors.forename: A V
authors.initials: AV
authors.lastname: Gordeets
authors.forename: E N
authors.initials: EN
authors.lastname: Iurusova
authors.forename: A N
authors.initials: AN
authors.lastname: Smagina
authors.forename: S L
authors.initials: SL
authors.lastname: Piskunova
mesh_terms: D000166:Acridines / Q000494:pharmacology / Q000627:therapeutic use*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000209:etiology / Q000628:therapy*; D005260:Female; D005759:Gastroenteritis / Q000209:etiology / Q000628:therapy; D006506:Hepatitis A / Q000276:immunology / Q000628:therapy; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000032:analysis / Q000378:metabolism*; D007378:Interleukins / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D015012:Yersinia pseudotuberculosis Infections / Q000276:immunology / Q000473:pathology / Q000628:therapy
chemical_list: D000166:Acridines; D007369:Interferon Inducers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007378:Interleukins; D011994:Recombinant Proteins; D007371:Interferon-gamma; C026430:10-carboxymethyl-9-acridanone