title: High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
abstract: In this study, we explore the association of thymidine kinase 1 (TK1) expression in tumour tissues with clinical pathological parameters and prognosis in patients with pathological T1 (pT1) lung adenocarcinoma. The expression of TK1 was studied by immunohistochemistry techniques in 80 patients with surgically resected pT1 lung adenocarcinoma, retrospectively and at >10-year follow-up. Compared to patients with low TK1 expression [labelling index (LI) <25.0%], patients with high TK1 expression (LI ≥ 25.0%) showed significantly increased lymphatic/vascular permeation and lymph node involvement and higher stromal invasion grade and pathological stage, and a greater number of patients had a tumour size of 2.1 to 3.0 cm. The 5-year survival and the mortality during follow-up for patients with high TK1 expression were significantly worse than that of patients with low TK1 expression. The prognoses of the cases with grade 0, grade 1 and grade 2 stromal invasions were similar and were better than those of cases with grade 3. In patients with stromal invasion grade 3, the 5-year survival and the mortality during follow-up were significantly worse for patients with high TK1 compared to patients with low TK1 expression. Univariate analyses showed that stromal invasion and TK1 expression were significant prognostic factors, while in the multivariate analysis, TK1 expression and tumour stage were found to be independent prognostic factors, but not stromal invasion. This is the first study showing that TK1 expression in combination with stromal invasion is a more reliable prognostic factor than stromal invasion classification itself in patients with pT1 lung adenocarcinoma. TK1 expression enables a further classification of the patients and opens opportunities for improved treatment outcome.
authors.affiliation: Department of Pathology, Nanjing Jinling Hospital, Nanjing University Medical School, 305 Zhongshangdong Road, Nanjing, 210002, Jiangsu Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Qun-Li
authors.initials: QL
authors.lastname: Shi
authors.forename: Henghui
authors.initials: H
authors.lastname: Ma
authors.forename: Hangbo
authors.initials: H
authors.lastname: Zhou
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
authors.forename: Staffan
authors.initials: S
authors.lastname: Eriksson
authors.forename: Ellen
authors.initials: E
authors.lastname: He
authors.forename: Sven
authors.initials: S
authors.lastname: Skog
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000201:enzymology; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008175:Lung Neoplasms / Q000201:enzymology* / Q000401:mortality; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D013937:Thymidine Kinase / Q000096:biosynthesis*
chemical_list: D013937:Thymidine Kinase; C092717:thymidine kinase 1