title: Phenolic compounds of Abies nephrolepis and their NO production inhibitory activities.
abstract: Two new, i.e., 1 and 2, and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D- and 2D-NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC(50) value of 13.7 μg/ml.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Dan-Wei
authors.initials: DW
authors.lastname: Ouyang
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.forename: Jia-Han
authors.initials: JH
authors.lastname: Xia
authors.forename: Yue-Xing
authors.initials: YX
authors.lastname: Pan
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Hua-Wu
authors.initials: HW
authors.lastname: Zeng
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide