title: Individual patient assessment of methadone-induced QT prolongation with digital holter recording.
abstract: A 27-year-old male who had been on methadone therapy for 6 months was investigated with a 12-lead digital holter because of a prolonged QT on a standard 12-lead electrocardiogram (ECG). The patient had 24-hour holter recording on and off methadone therapy and multiple digitized 12-lead ECG data were captured for on-screen measurement of the QT interval. For each 24-hour period QT-HR pairs were plotted on the QT nomogram showing QT prolongation on methadone but not when it was ceased. This provides a highly accurate method for evaluating drug-induced QT prolongation.
authors.affiliation: Department of Clinical Toxicology, Calvary Mater Newcastle Hospital, Edith St, Waratah New South Wales 2298, Australia.
authors.forename: Leonie
authors.initials: L
authors.lastname: Calver
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Dunlop
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Isbister
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use / Q000633:toxicity*; D059350:Chronic Pain / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory / Q000187:drug effects / Q000295:instrumentation*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008691:Methadone / Q000627:therapeutic use / Q000633:toxicity*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone