title: Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus.
abstract: Chitosan based microcapsule which encapsulated with phyllanthin was developed by simple coacervation. The composition and surface morphology of phyllanthin containing microcapsules were analyzed by Fourier Transform Infrared spectroscopy and Scanning Electron Microscopy, respectively. The release of phyllanthin from the microcapsules was found to be more than 60% after 120 h. In vitro biological assays demonstrated that these phyllanthin containing microcapsules showed a stronger anti-oxidation potential on both human fibroblasts and keratinocytes as well as a better growth inhibitory activity towards Staphylococcus aureus.
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Pik-Ling
authors.initials: PL
authors.lastname: Lam
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Joanne
authors.initials: J
authors.lastname: Yip
authors.forename: Marcus Chun-Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Johnny Cheuk-On
authors.initials: JC
authors.lastname: Tang
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000737:chemistry; D015195:Drug Design; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D017705:Lignans / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods*; D008956:Models, Chemical; D017382:Reactive Oxygen Species; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000378:metabolism*; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002214:Capsules; D017705:Lignans; D017382:Reactive Oxygen Species; C517985:phyllanthin; D048271:Chitosan