title: Changes in inflammatory biomarkers after successful lifestyle intervention in obese children.
abstract: BACKGROUND
  Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents.
  
  
  METHODS
  Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA(1c)), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention.
  
  
  RESULTS
  Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA(1c) and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters.
  
  
  CONCLUSIONS
  This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents.
authors.affiliation: Independent Laboratory of Propaedeutics of Children’s Diseases, Pomeranian Medical University, Szczecin, Poland. propedeutyka1@wp.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Garanty-Bogacka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Syrenicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Goral
authors.forename: Beata
authors.initials: B
authors.lastname: Krupa
authors.forename: Justyna
authors.initials: J
authors.lastname: Syrenicz
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Walczak
authors.forename: Anhelli
authors.initials: A
authors.lastname: Syrenicz
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000628:therapy; D010353:Patient Education as Topic; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose