title: Renal cancer and Wegener's granulomatosis: a case report.
abstract: Wegener's granulomatosis (WG) is a systemic disorder characterized by necrotizing vasculitis involving the respiratory tract, and in most cases, the kidneys. The most common manifestation of WG in the kidneys is segmental necrotizing glomerulonephritis. The presence of a renal mass as a manifestation of WG is rare. We report a patient with WG in whom a CT scan revealed an infiltrating mass in the lower portion of the left kidney. After surgical exploration, we performed an open radical nephrectomy. Histopathology showed clear cell type renal cell carcinoma (RCC). RCC associated with WG has been reported in only a few cases, and in most of them, the diseases started simultaneously, suggesting common pathogenetic pathways. Long-term immunosuppressive treatment is a known risk factor in the development of malignancies, so occurrence of RCC in WG has been proposed as a side effect of cyclophosphamide treatment. Furthermore, it is important to make a differential diagnosis between RCC and pseudotumors in WG as they cannot be distinguished solely on basis of imaging findings. Due to the higher risk of urologic malignancies, more frequent checkups and screening of WG patients should be considered.
authors.affiliation: Clinical Center of Serbia, Clinic of Urology, Resavska 51, 11000 Belgrade, Serbia. urosbu@gmail.com
authors.forename: Uros
authors.initials: U
authors.lastname: Bumbasirevic
authors.forename: Dejan
authors.initials: D
authors.lastname: Dragicevic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Janicic
authors.forename: Vesna
authors.initials: V
authors.lastname: Cemerikic-Martinovic
authors.forename: Milica
authors.initials: M
authors.lastname: Cekerevac
authors.forename: Vuk
authors.initials: V
authors.lastname: Aleksic
authors.forename: Cane
authors.initials: C
authors.lastname: Tulic
mesh_terms: D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis