title: Transgenic animal mutation models: a review of the models and how they function.
abstract: In regulatory genetic toxicology, the endpoints available for routine study in vivo have been limited to looking at chromosomal damage or unscheduled DNA synthesis in a very limited number of tissues. With the development of transgenic gene mutation systems in rodents came the opportunity to investigate a new endpoint. The better-known λLacI and λLacZ are covered in some detail and the less well established models do receive mention with appropriate references for those wishing more information. Using a recommended experimental design it is now possible to look at the ability of a compound to induce gene mutation following in vivo exposure, in any tissue from which suitable DNA can be isolated.
authors.affiliation: steve.dean@crocommunicationservices.com
authors.forename: Steve
authors.initials: S
authors.lastname: Dean
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D051379:Mice; D023421:Models, Animal; D009152:Mutagenicity Tests / Q000379:methods*; D009154:Mutation; D051381:Rats