title: Discrimination of Escherichia coli strains using glycan cantilever array sensors.
abstract: Carbohydrate-based sensors, that specifically detect sugar binding molecules or cells, are increasingly important in medical diagnostic and drug screening. Here we demonstrate that cantilever arrays functionalized with different mannosides allow the real-time detection of several  Escherichia coli  strains in solution. Cantilever deflection is thereby dependent on the bacterial strain studied and the glycan used as the sensing molecule. The cantilevers exhibit specific and reproducible deflection with a sensitivity range over four orders of magnitude.
authors.affiliation: Center for Nanoscience, Ludwig-Maximilians-Universität, Fakultät für Physik, Geschwister-Scholl-Platz 1, 80539 München, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Mader
authors.forename: Kathrin
authors.initials: K
authors.lastname: Gruber
authors.forename: Riccardo
authors.initials: R
authors.lastname: Castelli
authors.forename: Bianca A
authors.initials: BA
authors.lastname: Hermann
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.forename: Joachim O
authors.initials: JO
authors.lastname: Rädler
authors.forename: Madeleine
authors.initials: M
authors.lastname: Leisner
mesh_terms: D058491:Bacterial Load / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D004926:Escherichia coli / Q000145:classification* / Q000302:isolation & purification*; D008362:Mannosides / Q000737:chemistry*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation; D046228:Microarray Analysis / Q000295:instrumentation*; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D008362:Mannosides; D011134:Polysaccharides