title: [Bioinformatics analysis of nicotinamide phosphoribosyl transferase of Schistosoma japonicum].
abstract: OBJECTIVE
  To perform the bioinformatics analysis of nicotinamide phosphoribosyl transferase of Schistosoma japonicum so as to provide the evidence for the development and application of it.
  
  
  METHODS
  Internet online procedures and the related software were exploited to analyze the open reading frame (ORF) of SjNAMPT gene, physical and chemical properties of SjNAMPT protein and the domains of the protein, and predict the space structure and functions of the protein.
  
  
  RESULTS
  The SjNAMPT protein sequence was composed of 179 amino acids with 19.63 kDa of the molecular weight. The protein was stable and had no structures of transmembrane and helical coils. The protein belonged to the family of nicotinate phosphoribosyl transferase with multiple phosphorylation sites. The protein probably located in cytoplasm and dominated by random coils in second structure. The similarity of the SjNAMPT protein sequence was lower than that of other species of NAMPT.
  
  
  CONCLUSIONS
  SjNAMPT is a specific protein of Schistosoma japonicum with a certain activity, and probably related to purine metabolism and glucose metabolism. It is worth for further study.
authors.affiliation: School of life Sciences, Nanchang University, Nanchang 330046, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ge
authors.forename: Hong-Gen
authors.initials: HG
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D008969:Molecular Sequence Data; D054409:Nicotinamide Phosphoribosyltransferase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D012549:Schistosoma japonicum / Q000737:chemistry / Q000145:classification / Q000201:enzymology* / Q000235:genetics
chemical_list: D015801:Helminth Proteins; D054409:Nicotinamide Phosphoribosyltransferase