title: Regenerative tendon and ligament healing: opportunities with recombinant human platelet-derived growth factor BB-homodimer.
abstract: Intrinsic tendon healing in response to injury is a reparative process that often results in formation of scar tissue with functional and mechanical properties inferior to those of the native tendon. Development of therapies that can promote regenerative, rather than reparative, healing hold the promise of improving patient recovery from tendon and ligament injuries by producing tissue that is morphologically and functionally equivalent to the native tissue. One therapeutic approach that has been a frequent topic of investigation in the preclinical literature is the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to augment tendon and ligament repair. The chemotactic, mitogenic, and pro-angiogenic properties of rhPDGF-BB have been shown to result in recruitment and proliferation of tenogenic cells and a commensurate boost in extracellular matrix deposition and organization, improving the morphological and biomechanical properties of healing tendons and ligaments. The outcomes of the preclinical studies reviewed here strongly suggest that rhPDGF-BB will provide a new therapeutic opportunity to improve the treatment of injured tendons and ligaments.
authors.affiliation: BioMimetic Therapeutics Inc., Franklin, Tennessee 37067, USA. chee@biomimetics.com
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Hee
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Dines
authors.forename: Luis A
authors.initials: LA
authors.lastname: Solchaga
authors.forename: Vivek R
authors.initials: VR
authors.lastname: Shah
authors.forename: Jeffrey O
authors.initials: JO
authors.lastname: Hollinger
mesh_terms: D000818:Animals; D000077214:Becaplermin; D006801:Humans; D008022:Ligaments / Q000187:drug effects / Q000473:pathology*; D055503:Protein Multimerization / Q000187:drug effects*; D020574:Proto-Oncogene Proteins c-sis / Q000737:chemistry / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects*; D013710:Tendons / Q000187:drug effects / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin