title: Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm.
abstract: Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Jayapal
authors.initials: J
authors.lastname: Manikandan
authors.forename: Narasimhan
authors.initials: N
authors.lastname: Kothandaraman
authors.forename: Manoor Prakash
authors.initials: MP
authors.lastname: Hande
authors.forename: Peter Natesan
authors.initials: PN
authors.lastname: Pushparaj
mesh_terms: D000707:Anaphylaxis / Q000235:genetics* / Q000276:immunology; D000818:Animals; D001491:Basophils / Q000276:immunology; D015550:Cell Degranulation / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D023281:Genomics; D006632:Histamine / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D051381:Rats; D017455:Receptors, IgE / Q000235:genetics* / Q000276:immunology
chemical_list: D017455:Receptors, IgE; D007073:Immunoglobulin E; D006632:Histamine