title: A case of cholestatic hepatitis associated with histologic features of acute cholangitis.
abstract: This report describes a case showing histologic features of acute cholangitis with an over-the-counter drug. A 48-year-old woman was diagnosed with general malaise and progressive jaundice. A thorough review of her medical history revealed that the patient had taken an over-the-counter drug, Pabron Gold(®), which she had used previously, that may have caused liver injury. Laboratory investigations revealed jaundice and liver dysfunction. Endoscopic retrograde cholangiography detected no extrahepatic biliary duct dilatation or stones. Liver biopsy indicated acute cholangitis involving neutrophils and eosinophils. Electron microscopy revealed fragmented nuclei, indicating that the degenerative bile duct-related epithelial cells were in an apoptotic process.
authors.affiliation: Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Saitama.
authors.forename: Hajime
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Toru
authors.initials: T
authors.lastname: Kaneko
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Otsuka
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tahara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Motoori
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohbu
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokomori