title: Perspectives of zebrafish models of epilepsy: what, how and where next?
abstract: Epilepsy is a complex brain disorder with multiple underlying causes and poorly understood pathogenetic mechanisms. Animal models have been indispensable tools in experimental epilepsy research. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism to study various brain disorders. Seizure-like behavioral and neurophysiological responses can be evoked in larval and adult zebrafish by various pharmacological and genetic manipulations, collectively emphasizing the growing utility of this model for studying epilepsy. Here, we discuss recent developments in using zebrafish models to study the seizure-like behavior involved in epilepsy, outlining current challenges and strategies for further translational research in this field.
authors.affiliation: Department of Pharmacology and Neuroscience Program, Tulane University Medical School, 1430 Tulane Ave., New Orleans, LA 70112, USA.
authors.forename: Adam Michael
authors.initials: AM
authors.lastname: Stewart
authors.forename: Daniel
authors.initials: D
authors.lastname: Desmond
authors.forename: Evan
authors.initials: E
authors.lastname: Kyzar
authors.forename: Siddharth
authors.initials: S
authors.lastname: Gaikwad
authors.forename: Andrew
authors.initials: A
authors.lastname: Roth
authors.forename: Russell
authors.initials: R
authors.lastname: Riehl
authors.forename: Christopher
authors.initials: C
authors.lastname: Collins
authors.forename: Louis
authors.initials: L
authors.lastname: Monnig
authors.forename: Jeremy
authors.initials: J
authors.lastname: Green
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D015027:Zebrafish
chemical_list: D000927:Anticonvulsants