title: The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor.
abstract: The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABA(C)-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABA(C).
authors.affiliation: Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia.
authors.forename: Izumi
authors.initials: I
authors.lastname: Yamamoto
authors.forename: Meredith J T
authors.initials: MJ
authors.lastname: Jordan
authors.forename: Navnath
authors.initials: N
authors.lastname: Gavande
authors.forename: Munikumar R
authors.initials: MR
authors.lastname: Doddareddy
authors.forename: Mary
authors.initials: M
authors.lastname: Chebib
authors.forename: Luke
authors.initials: L
authors.lastname: Hunter
mesh_terms: D000613:Aminobutyrates / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D018755:GABA Agonists / Q000737:chemistry* / Q000378:metabolism; D018756:GABA Antagonists / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D009865:Oocytes / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D018079:Receptors, GABA / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D014981:Xenopus
chemical_list: D000613:Aminobutyrates; D018755:GABA Agonists; D018756:GABA Antagonists; C087200:GABA-C receptor; D018079:Receptors, GABA