title: [Management of hypercholesterolemia: what target for LDL cholesterol?].
abstract: Low-density lipoprotein cholesterol (LDL-c) concentration is an independent cardiovascular risk factor, which mostly contributes to the development and progression of atherosclerosis. Results of randomized clinical trial with statins demonstrate that the optimal LDL-c target is < 70 mg/dL. The physiological range of LDL-c in hunter-gatherers and wild mammals, who do not develop atherosclerosis, is 0.5 to 0.7 g/L. No major safety concern was found in human with genetically-related low levels of LDL-c. A moderate increase in haemorrhagic stroke and diabetes was found in some trials with statins. Guidelines recommend to modulate the LDL-c target according to the level of the total cardiovascular risk.
authors.affiliation: Clinique d'endocrinologie, hôpital Guillaume-et-René-Laennec, CHU de Nantes, 44093 Saint-Herblain Cedex 1. bertrand.cariou@univ-nantes.fr
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cariou
authors.forename: Michel
authors.initials: M
authors.lastname: Krempf
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications* / Q000628:therapy; D050356:Lipid Metabolism
chemical_list: D008078:Cholesterol, LDL