title: Chemical synthesis of the englerins.
abstract: In the long lasting battle against cancer, Nature sometimes gives a helping hand to researchers to find new drugs for the treatment of diseases and improvement of patients' well-being. Englerin A has emerged as a promising anticancer candidate as well as being an exciting synthetic challenge for organic chemists. This focus review summarizes the total syntheses reported to date and the synthetic approaches toward analogues of this fascinating natural product.
authors.affiliation: Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane Innovation Park, Nathan, Qld 4111, Australia.
authors.forename: Rebecca H
authors.initials: RH
authors.lastname: Pouwer
authors.forename: Jean-Alexandre
authors.initials: JA
authors.lastname: Richard
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Tseng
authors.forename: David Y-K
authors.initials: DY
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D045789:Sesquiterpenes, Guaiane / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D045789:Sesquiterpenes, Guaiane; C534971:englerin A; C551614:englerin B