title: Total regression of extensive conjunctival intraepithelial neoplasia with superficial corneal invasion treated with topical mitomycin C 0.02%.
abstract: OBJECTIVE
  To report complete resolution of extensive conjunctival intraepithelial neoplasia in a patient treated with topical mitomycin C.
  
  
  METHODS
  Based on clinical examination, impression cytology was performed on the corneal-conjunctival lesion. Management consisted of topical mitomycin 0.02%, administered four times a day for four 1-week cycles, with 1 week off between cycles.
  
  
  RESULTS
  Complete resolution of the neoplasm was observed by slit lamp examination at 5 weeks of treatment, and histological resolution by 7 weeks of treatment. There were no complications due to the use of mitomycin.
  
  
  CONCLUSIONS
  Topical mitomycin C 2 mg/ml (0.02%) may be a safe and effective treatment for conjunctival intraepithelial neoplasm prior to surgical removal.
authors.affiliation: Hospital Vall D'hebron, Ophthalmology, Paseo Vall D'hebron 119-129, Barcelona, 08035, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Calatayud
authors.forename: Josep
authors.initials: J
authors.lastname: Badal
authors.forename: Laia
authors.initials: L
authors.lastname: Bisbe
authors.forename: Sara
authors.initials: S
authors.lastname: Martin
authors.forename: Javier
authors.initials: J
authors.lastname: Puig