title: Malignant potential of pleomorphic xanthoastrocytoma.
abstract: Pleomorphic xanthoastrocytoma (PXA) is a low-grade astrocytic tumour that occasionally progresses to a higher grade. We have extensively reviewed the literature on the potential for malignant transformation of PXA. An illustrative case of a PXA transforming to glioblastoma multiforme is presented.
authors.affiliation: Department of Neurosurgery, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.
authors.forename: Tamara M
authors.initials: TM
authors.lastname: Vu
authors.forename: Simon V
authors.initials: SV
authors.lastname: Liubinas
authors.forename: Michael
authors.initials: M
authors.lastname: Gonzales
authors.forename: Katharine J
authors.initials: KJ
authors.lastname: Drummond
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology* / Q000628:therapy; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology*; D002648:Child; D003131:Combined Modality Therapy / Q000379:methods / Q000592:standards; D005260:Female; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging / Q000592:standards; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor