title: Immune profiling of Alzheimer patients.
abstract: Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.
authors.affiliation: Department of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen Aging and Tumor Immunology group, Waldhörnlestr. 22, 72072 Tübingen, Germany. mariavaleria.pellicano@uni-tuebingen.de
authors.forename: Mariavaleria
authors.initials: M
authors.lastname: Pellicanò
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.forename: David
authors.initials: D
authors.lastname: Goldeck
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Colonna-Romano
authors.forename: Silvio
authors.initials: S
authors.lastname: Buffa
authors.forename: Matteo
authors.initials: M
authors.lastname: Bulati
authors.forename: Graziella
authors.initials: G
authors.lastname: Rubino
authors.forename: Francesco
authors.initials: F
authors.lastname: Iemolo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Evelyna
authors.initials: E
authors.lastname: Derhovanessian
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers