title: A soyabean diet does not modify the activity of brown adipose tissue but alters the rate of lipolysis in the retroperitoneal white adipose tissue of male rats recovering from early-life malnutrition.
abstract: Nutritional recovery with a soyabean diet decreases body and fat weights when compared with a casein diet. We investigated whether the reduced adiposity observed in rats recovering from early-life malnutrition with a soyabean diet results from alterations in lipid metabolism in white adipose tissue (WAT) and/or brown adipose tissue (BAT). Male rats from mothers fed either 17 or 6 % protein during pregnancy and lactation were maintained on 17 % casein (CC and LC groups), 17 % soyabean (CS and LS groups) or 6 % casein (LL group) diets over 60 d. The rats maintained on a soyabean diet had similar relative food intakes, but lower body and retroperitoneal WAT weights and a reduced lipid content in the retroperitoneal WAT. The insulin levels were lower in the recovered rats and were elevated in those fed a soyabean diet. Serum T3 concentration and uncoupling protein 1 content in the BAT were decreased in the recovered rats. The thermogenic capacity of the BAT was not affected by the soyabean diet. The lipogenesis rate in the retroperitoneal WAT was similar in all of the groups except for the LL group, which had exacerbated lipogenesis. The enhancement of the lipolysis rate by isoproterenol was decreased in white adipocytes from the soyabean-recovered rats and was elevated in adipocytes from the soyabean-control rats. Thus, in animals maintained on a soyabean diet, the proportions of fat deposits are determined by the lipolysis rate, which differs depending on the previous nutritional status.
authors.affiliation: Departamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
authors.forename: Adriene Alexandra
authors.initials: AA
authors.lastname: Paiva
authors.forename: Jaline Zandonato
authors.initials: JZ
authors.lastname: Faiad
authors.forename: Marina Satie
authors.initials: MS
authors.lastname: Taki
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: de Lima Reis
authors.forename: Letícia Martins Ignácio
authors.initials: LM
authors.lastname: de Souza
authors.forename: Maísa Pavani
authors.initials: MP
authors.lastname: Dos Santos
authors.forename: Valéria Ernestânia
authors.initials: VE
authors.lastname: Chaves
authors.forename: Nair Honda
authors.initials: NH
authors.lastname: Kawashita
authors.forename: Helena Coutinho Franco
authors.initials: HC
authors.lastname: de Oliveira
authors.forename: Helena Fonseca
authors.initials: HF
authors.lastname: Raposo
authors.forename: Everardo Magalhães
authors.initials: EM
authors.lastname: Carneiro
authors.forename: Márcia Queiroz
authors.initials: MQ
authors.lastname: Latorraca
authors.forename: Maria Helena Gaíva
authors.initials: MH
authors.lastname: Gomes-da-Silva
authors.forename: Maria Salete Ferreira
authors.initials: MS
authors.lastname: Martins
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000473:pathology; D050154:Adiposity; D000818:Animals; D002478:Cells, Cultured; D018753:Diet, Protein-Restricted / Q000009:adverse effects; D014676:Diet, Vegetarian / Q000009:adverse effects; D005260:Female; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000473:pathology; D007774:Lactation; D008066:Lipolysis; D008297:Male; D044342:Malnutrition / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012187:Retroperitoneal Space; D012639:Seeds / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*