title: Novel modifications in RNA.
abstract: The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on the parent RNAs. In this review, we describe recent discoveries in these areas with a focus on RNA modifications that introduce spectroscopic tags, reactive handles, or new recognition properties.
authors.affiliation: Department of Chemistry, University of California, Davis, 95616, United States.
authors.forename: Kelly
authors.initials: K
authors.lastname: Phelps
authors.forename: Alexi
authors.initials: A
authors.lastname: Morris
authors.forename: Peter A
authors.initials: PA
authors.lastname: Beal
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000378:metabolism; D001386:Azides / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D057930:Click Chemistry / Q000379:methods*; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D055029:Inverted Repeat Sequences; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D009705:Nucleosides / Q000737:chemistry / Q000378:metabolism; D059372:Nucleotide Motifs / Q000235:genetics*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D000480:Alkynes; D001386:Azides; D005456:Fluorescent Dyes; D005609:Free Radicals; D015335:Molecular Probes; D009705:Nucleosides; D034741:RNA, Small Interfering; D014050:Toluene; C110527:difluorotoluene