title: Conducting polymer 3D microelectrodes.
abstract: Conducting polymer 3D microelectrodes have been fabricated for possible future neurological applications. A combination of micro-fabrication techniques and chemical polymerization methods has been used to create pillar electrodes in polyaniline and polypyrrole. The thin polymer films obtained showed uniformity and good adhesion to both horizontal and vertical surfaces. Electrodes in combination with metal/conducting polymer materials have been characterized by cyclic voltammetry and the presence of the conducting polymer film has shown to increase the electrochemical activity when compared with electrodes coated with only metal. An electrochemical characterization of gold/polypyrrole electrodes showed exceptional electrochemical behavior and activity. PC12 cells were finally cultured on the investigated materials as a preliminary biocompatibility assessment. These results show that the described electrodes are possibly suitable for future in-vitro neurological measurements.
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads 345ø, 2800 Kgs. Lyngby, Denmark. luigi.sasso@nanotech.dtu.dk
authors.forename: Luigi
authors.initials: L
authors.lastname: Sasso
authors.forename: Patricia
authors.initials: P
authors.lastname: Vazquez
authors.forename: Indumathi
authors.initials: I
authors.lastname: Vedarethinam
authors.forename: Jaime
authors.initials: J
authors.lastname: Castillo-León
authors.forename: Jenny
authors.initials: J
authors.lastname: Emnéus
authors.forename: Winnie E
authors.initials: WE
authors.lastname: Svendsen
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004553:Electric Conductivity; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D006046:Gold / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D008422:Materials Testing; D008839:Microelectrodes / Q000009:adverse effects; D008954:Models, Biological; D008968:Molecular Conformation; D016716:PC12 Cells; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry; D051381:Rats
chemical_list: D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D006046:Gold