title: The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.
abstract: Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex-like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (T(H)2)-associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis.
authors.affiliation: London Research Institute, Cancer Research UK, London WC2A 3LY, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Strid
authors.forename: Olga
authors.initials: O
authors.lastname: Sobolev
authors.forename: Biljana
authors.initials: B
authors.lastname: Zafirova
authors.forename: Bojan
authors.initials: B
authors.lastname: Polic
authors.forename: Adrian
authors.initials: A
authors.lastname: Hayday
mesh_terms: D000818:Animals; D004817:Epidermis / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D008024:Ligands; D008221:Lymphoid Tissue / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000276:immunology / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D013312:Stress, Physiological; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D015854:Up-Regulation
chemical_list: C527086:Klrk1 protein, mouse; D008024:Ligands; D008565:Membrane Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; C491218:Raet1b protein, mouse; D016692:Receptors, Antigen, T-Cell, gamma-delta