title: [Clinical effect of chitosan in bacterial vaginosis therapy].
abstract: OBJECTIVE
  Determination of antibacterial activity of acid-soluble chitosan in bacterial vaginosis therapy in women of reproductive age and comparison of therapy results of traditional scheme and local administration of acid-soluble chitosan.
  
  
  METHODS
  Vaginal microflora of 76 gynecologic and obstetrical female patients (18-43 years of age) with bacterial vaginosis diagnosis was examined by using bacteriological method. Control group consisted of 30 practically healthy women. Sensitivity of 145 bacteria strains from 14 genera to 2% acid-soluble chitosan solution (200-250 kDa molecularweight) was determined by using agar diffusion method.
  
  
  RESULTS
  During bacterial vaginosis members of the Gardnerella, Mobiluncus and Bacteroides genera dominated with a background reduction of lactobacilli quantity. An increase of population level of Staphylococcus, Enterococcus, Prevotella, Porphyromonas, Peptostreptococcus genera members, and Candida species was also observed. All the microorganisms were sensitive to 2% chitosan solution. Mycoplasma and Ureaplasma spp. were sensitive to chitosan in 82% of cases. Administration of chitosan in local therapy of vaginosis resulted in suppression of opportunistic microflora and clinical effect with a lack of adverse effects.
  
  
  CONCLUSIONS
  Local administration of chitosan is perspective against bacterial vaginosis.
authors.forename: V M
authors.initials: VM
authors.lastname: Chervinets
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Chervinets
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
authors.forename: I I
authors.initials: II
authors.lastname: Stol'nikova
authors.forename: A M
authors.initials: AM
authors.lastname: Samoukina
authors.forename: E S
authors.initials: ES
authors.lastname: Mikhaĭlova
authors.forename: A I
authors.initials: AI
authors.lastname: Albulov
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D048271:Chitosan / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D048271:Chitosan