title: Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae).
abstract: Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components.
authors.affiliation: EA 4267, UFR des Sciences Médicales et Pharmaceutiques, Université de Franche-Comté, Besançon, France.
authors.forename: François
authors.initials: F
authors.lastname: Senejoux
authors.forename: Céline
authors.initials: C
authors.lastname: Demougeot
authors.forename: Parhat
authors.initials: P
authors.lastname: Kerram
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
authors.forename: Alain
authors.initials: A
authors.lastname: Berthelot
authors.forename: Françoise
authors.initials: F
authors.lastname: Bévalot
authors.forename: Corine
authors.initials: C
authors.lastname: Girard-Thernier
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D001681:Biological Assay; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D014665:Vasodilator Agents