title: The prevalence of pulmonary embolism in chronically paralyzed subjects: a review of available evidence.
abstract: METHODS
  Qualitative systematic review.
  
  
  OBJECTIVE
  To examine the validity of the prevailing notion that pulmonary embolism (PE) is rare in the chronic spinal cord injury (SCI) population.
  
  
  METHODS
  USA.
  
  
  METHODS
  Review surveys of adult SCI subjects >2 months after injury in which PE has been looked for and its prevalence estimated.
  
  
  RESULTS
  A total of 16 surveys of chronic SCI subjects published between 1956 and 2009 offered data on PE prevalence. Two autopsy surveys, 178 subjects paralyzed >2 months, revealed no PE. Eleven surveys of the cause of death, 3193 subjects paralyzed 1-25 years, revealed PE in 2.1%. Two surveys of survivors of SCI, 5761 subjects paralyzed 1-25 years, revealed PE in 0.4%. Our survey of 112 subjects paralyzed 1-50 years before death, revealed PE in 21 (18.7%), based on autopsy, imaging, clinical and electrocardiographic evidence. In 7 (33%) of the 21 subjects with PE, pulmonary hypertension by transthoracic echocardiography was detected, indicating recurrent and/or unresolved PE.
  
  
  CONCLUSIONS
  PE is not infrequent in the chronic SCI subject; but its presentation may be subclinical; and its apparent recurrence may lead to pulmonary hypertension.
authors.affiliation: Medical Service, Boston Veterans Affairs Healthcare System, St Paul, MN 55115, USA. jfrisbie@comcast.net
authors.forename: J H
authors.initials: JH
authors.lastname: Frisbie
authors.forename: G V R K
authors.initials: GV
authors.lastname: Sharma
mesh_terms: D002908:Chronic Disease; D006801:Humans; D010243:Paralysis / Q000209:etiology; D015995:Prevalence; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000209:etiology*; D013119:Spinal Cord Injuries / Q000150:complications*