title: Cutaneous lymphomas: molecular pathways leading to new drugs.
abstract: Currently, cutaneous lymphomas represent a paradigm for the heterogeneity and the dynamic variability of neoplastic disorders resulting in the accumulation of clonal lymphocytes in the skin, and thus mirror the complexity of lymphocytic populations. Increasing knowledge and insight in pathobiology offer new opportunities for targeted interventions to selectively hit the tumor populations. mAbs, rexinoids, small kinase inhibitors, or molecules interfering with methylation or histone acetylation contribute to disease control. The rational and well-coordinated application of these tools, together with improved chemotherapeutic options, will hopefully further improve treatment success in the near future.
authors.affiliation: Department of Dermatology, University Hospital Zürich, Zürich, Switzerland. reinhard.dummer@usz.ch
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
authors.forename: Simone M
authors.initials: SM
authors.lastname: Goldinger
authors.forename: Antonio
authors.initials: A
authors.lastname: Cozzio
authors.forename: Lars E
authors.initials: LE
authors.lastname: French
authors.forename: Maria B
authors.initials: MB
authors.lastname: Karpova
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D055808:Drug Discovery; D004359:Drug Therapy, Combination; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D061988:Proteasome Inhibitors; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D012176:Retinoids / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D061988:Proteasome Inhibitors; D047428:Protein Kinase Inhibitors; D012176:Retinoids