title: Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats.
abstract: Phloridzin is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased. Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.
authors.affiliation: Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran. M.najafian@Jia.ac.ir
authors.forename: Mahmood
authors.initials: M
authors.lastname: Najafian
authors.forename: Mohammad Zareain
authors.initials: MZ
authors.lastname: Jahromi
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Nowroznejhad
authors.forename: Parastoo
authors.initials: P
authors.lastname: Khajeaian
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Kargar
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sadeghi
authors.forename: Amir
authors.initials: A
authors.lastname: Arasteh
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy* / Q000652:urine; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D010695:Phlorhizin / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D010695:Phlorhizin