title: Glaucoma and frequency of ocular and general diseases in 30 patients with aniridia: a clinical study.
abstract: OBJECTIVE
  To evaluate the following in patients with aniridia: age at first examination at the University Eye Hospital and age at diagnosis of glaucoma; visual acuity; frequency of family history of aniridia; and frequency of ocular and general diseases associated with aniridia.
  
  
  METHODS
  This was a consecutive examination of 30 unrelated patients with aniridia and retrospective evaluation of ophthalmologic, pediatric, and internal findings. The relative frequency of age at glaucoma diagnosis within decades was evaluated for the 20 patients with aniridia and glaucoma. Statistical analysis was performed using the Mann-Whitney test.
  
  
  RESULTS
  Relative frequency of the age of patients with aniridia at time of glaucoma diagnosis within the following decades was as follows: from birth to 9 years: 15%, 10-19: 15%, 20-29: 15%, 30-39: 15%, 40-49: 35%, and 50-59: 5%. Visual acuity in the better eye of 20/100 or less was found in 60%. Family history of aniridia was found in 33.3% of patients, with 1-4 relatives with aniridia. A total of 76.7% of patients had congenital cataract, and 66.7% had glaucoma. Mean maximum intraocular pressure of the 20 patients with glaucoma was 35.9 mmHg in the right and 32.6 mmHg in the left eye. A total of 53.3% had nystagmus, 26.6% corneal opacifications, 16.7% bilateral lens dislocation upwards, 6.7% optic nerve hypoplasia, 3.3% poor foveal development, and 3.3% Wilms tumor.
  
  
  CONCLUSIONS
  Up to the age of 40 years, 15% of patients were diagnosed with glaucoma per age decade. Frequent bilateral glaucoma and similar bilateral height of intraocular pressure suggest a genetic glaucoma disposition with malformation at Schlemm canal, besides possible sequential anatomic changes in the chamber angle. Associated ocular abnormalities limit visual prognosis.
authors.affiliation: Department of Ophthalmology, University Würzburg, Würzburg, Germany. EugenGramer@aol.com
authors.forename: Eugen
authors.initials: E
authors.lastname: Gramer
authors.forename: Constantin
authors.initials: C
authors.lastname: Reiter
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Gramer
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D015783:Aniridia / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005128:Eye Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics; D005858:Germany / Q000453:epidemiology; D005901:Glaucoma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D006068:Gonioscopy; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000502:physiology; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000235:genetics; D008875:Middle Aged; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D009396:Wilms Tumor / Q000453:epidemiology* / Q000235:genetics; D055815:Young Adult
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins