title: CXCL12: a new player in coronary disease identified through human genetics.
abstract: Genome-wide association studies (GWAS) of more than 100,000 people have revealed novel loci associated with coronary artery disease and myocardial infarction that present exciting opportunities to discover novel disease pathways. One such recently identified locus is on chromosome 10q11, near the gene for the chemokine CXCL12, which has been implicated in cardiovascular disease in both mouse and human studies. These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis.
authors.affiliation: Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
authors.forename: Samira S
authors.initials: SS
authors.lastname: Farouk
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
authors.forename: Muredach P
authors.initials: MP
authors.lastname: Reilly
authors.forename: Nehal N
authors.initials: NN
authors.lastname: Mehta
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D054377:Chemokine CXCL12 / Q000235:genetics* / Q000378:metabolism; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D055106:Genome-Wide Association Study; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D054377:Chemokine CXCL12