title: Eosinophilic esophagitis and pharyngitis presenting as mass lesion in a patient with inactive rheumatoid arthritis.
abstract: We describe here a case of longstanding rheumatoid arthritis (RA) presenting with recurrent episodes of epigastric pain, melena, nonprogressive dysphagia, and hoarseness associated with persistent peripheral blood eosinophilia. Her RA was clinically inactive, but she had significant lymphadenopathy and hepatosplenomegaly. Computed tomographic scan of the thorax revealed circumferential wall thickening extending from the oropharynx to the gastroesophageal junction with a large polypoidal mass projecting into the lumen of the stomach. Histology revealed infiltration of the esophageal mucosa by eosinophils with a density of 40 to 80 per high-power field. The stratified squamous epithelium of the pharyngeal mucosa was also infiltrated by eosinophils with a density of more than 100 per high-power field. Eosinophilic esophagitis and pharyngitis were diagnosed, and the patient was administered corticosteroids and hydroxyurea, following which her symptoms resolved. On repeat imaging, there was significant reduction in esophageal wall thickening and luminal dilatation. There are few reports of tissue eosinophilia in association with RA, but the pathogenesis and any definite association with RA are not clear.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Christian Medical College and Hospital, Vellore, India. dia_naaz@yahoo.co.in
authors.forename: Pulukool
authors.initials: P
authors.lastname: Sandhya
authors.forename: Debashish
authors.initials: D
authors.lastname: Danda
authors.forename: John
authors.initials: J
authors.lastname: Mathew
authors.forename: Susy
authors.initials: S
authors.lastname: Kurian
authors.forename: Balakrishna Siddhartha
authors.initials: BS
authors.lastname: Ramakrishna
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D003680:Deglutition Disorders / Q000209:etiology; D004359:Drug Therapy, Combination; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D010612:Pharyngitis / Q000175:diagnosis* / Q000188:drug therapy; D011282:Pregnenediones / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D019384:Nucleic Acid Synthesis Inhibitors; D011282:Pregnenediones; D054328:Proton Pump Inhibitors; C021988:deflazacort; D006918:Hydroxyurea