title: Is the fasting calcium/creatinine a bone resorption marker in patients with calcium renal stones?
abstract: Osteoporosis and osteopenia are an important endocrine-metabolic disease that affect women and men from a certain age and it has a high risk and health cost. The aim of this short communication is to show that fasting calcium/creatinine ratio in patients with calcium stones is a marker of bone resorption.We studied 180 patients with renal stones with calcium composition and the relationship of them between the calcium/creatinine in urine after 8 h of fasting with bone densitometry (T-score) and values of bone resorption marker β-crosslaps (ng/ml). The Pearson correlation test was applied for the analysis of linear correlations between quantitative variables.We have observed a statistically significant positive linear correlation between the fasting calcium/creatinine and serum and β-crosslaps (R = 0.534, p < 0.0001) and a statistically significant negative linear correlation between fasting calcium/creatinine and T-score of bone densitometry in hip (R = -0.237, p = 0.002), femoral neck (R = -0.217, p = 0.009) and lumbar spine (R = 0.292, p = 0.001).The fasting ratio calcium/creatinine in urine is associated with increased levels of β-crosslaps marker and therefore may be useful as a marker of bone resorption in these patients.
authors.affiliation: Department of Urology, San Cecilio University Hospital, Granada, Spain. arrabalp@ono.com
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Arrabal-Polo
authors.forename: Miguel
authors.initials: M
authors.lastname: Arrabal-Martin
authors.forename: Antonio
authors.initials: A
authors.lastname: Poyatos-Andujar
authors.forename: Encarnacion
authors.initials: E
authors.lastname: Cardenas-Grande
authors.forename: Sergio
authors.initials: S
authors.lastname: Merino-Salas
authors.forename: Armando
authors.initials: A
authors.lastname: Zuluaga-Gomez
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D001862:Bone Resorption / Q000175:diagnosis* / Q000652:urine; D002118:Calcium / Q000652:urine*; D003094:Collagen / Q000097:blood; D003404:Creatinine / Q000652:urine*; D005215:Fasting / Q000652:urine*; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D003094:Collagen; D003404:Creatinine; D002118:Calcium