title: Cardiac function in 7-8-year-old offspring of women with type 1 diabetes.
abstract: Offspring of type 1 diabetic mothers (ODMs) are at risk of short-term and long-term complications, such as neonatal macrosomia (birth weight >90th percentile), hypertrophic cardiomyopathy, and cardiovascular morbidity in later life. However, no studies have been performed regarding cardiac outcome. In this study, we investigated cardiac dimensions and function in 30 ODMs at 7-8 years of age in relation to neonatal macrosomia and maternal glycemic control during pregnancy and compared these with those in a control group of 30 children of nondiabetic women. We found that cardiac dimensions and systolic and diastolic function parameters in ODMs were comparable with those in controls. Neonatal macrosomia and poorer maternal glycemic control during pregnancy were not related to worse cardiac outcome in ODM. We conclude that cardiac function at 7-8 years of age in offspring of women with type 1 diabetes is reassuring and comparable with that in controls.
authors.affiliation: Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, 3508 AB Utrecht, The Netherlands. m.rijpert@umcutrecht.nl
authors.forename: Maarten
authors.initials: M
authors.lastname: Rijpert
authors.forename: Johannes M P J
authors.initials: JM
authors.lastname: Breur
authors.forename: Inge M
authors.initials: IM
authors.lastname: Evers
authors.forename: Harold W
authors.initials: HW
authors.lastname: de Valk
authors.forename: Cobi J
authors.initials: CJ
authors.lastname: Heijnen
authors.forename: Folkert J
authors.initials: FJ
authors.lastname: Meijboom
authors.forename: Gerard H A
authors.initials: GH
authors.lastname: Visser
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose