title: Terpenoids from Maytenus species and assessment of their reversal activity against a multidrug-resistant Leishmania tropica line.
abstract: The phytochemical analysis of the root bark extracts of the Chilean Maytenus, M. chubutensis, and M. magellanica (Celastraceae), led to the isolation of one phenolic nortriterpene, 1, and one diterpene with a nor-ent-kaurene skeleton, 2. In addition, four known compounds were isolated, among which compound 3 has been isolated for the first time from a natural source. Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR (COSY, ROESY, HSQC, and HMBC) experiments, comparison with data reported in the literature, and chemical correlations. The isolated compounds were assayed for their reversal activity against a multidrug-resistant Leishmania tropica line, overexpressing a P-glycoprotein related transporter. Compound 1 showed moderate multidrug-resistance reversal activity.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, La Laguna, Tenerife.
authors.forename: María L
authors.initials: ML
authors.lastname: Kennedy
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Llanos
authors.forename: Santiago
authors.initials: S
authors.lastname: Castanys
authors.forename: Francisco
authors.initials: F
authors.lastname: Gamarro
authors.forename: Isabel L
authors.initials: IL
authors.lastname: Bazzocchi
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Jiménez
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D007895:Leishmania tropica / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D013729:Terpenes