title: Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.
abstract: Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. dsimon@cbm.uam.es
authors.forename: Diana
authors.initials: D
authors.lastname: Simón
authors.forename: Esther
authors.initials: E
authors.lastname: García-García
authors.forename: Felix
authors.initials: F
authors.lastname: Royo
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Falcón-Pérez
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000818:Animals; D019556:COS Cells; D016923:Cell Death; D002460:Cell Line; D002522:Chlorocebus aethiops; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016875:tau Proteins