title: Solid-supported gallium triflate: an efficient catalyst for the three-component ketonic Strecker reaction.
abstract: In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)(2) ) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid-supported catalysis and the emerging area of micro-reaction technology, we screened PS-Ga(OTf)(2)  for activity towards the ketonic Strecker reaction, in which the target α-aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used.
authors.affiliation: Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wiles
authors.forename: Paul
authors.initials: P
authors.lastname: Watts
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D055616:Microtechnology / Q000295:instrumentation*
chemical_list: D000447:Aldehydes; D007659:Ketones; D008698:Mesylates; C516572:gallium triflate