title: [The unity of image recognition of tolite homothetic receptors and glycosylation end product receptors in biologic function in case of diabetes].
abstract: In compliance with our theory of biologic functions and reactions, pathogenesis of all diseases in formed in the framework of disorder of seven biologic functions: trophology, homeostasis, endoecology, adaptation, locomotion, genus continuation and intelligence. The disorder of biologic function of endoecology ("purity" of intercellular medium in vivo) is the most common basis of pathogenesis of diseases' nosological forms. There are two methods of elimination of disorder of this function. First is the biological reaction of excretion i.e. the removal of minor endogenic phlogogenes (initiators of inflammation) with molecular weightless than 70 amu. The second is the biological function of inflammation i.e. utilization of large endogenic phlogogenes (more than 70 amu) by means of phagocytosis of functional phagocytes. The inherent and acquired immunity are other biological reactions of biological function of endoecology. They overlap with biological reaction of transcytosis and biological reaction of hydrodynamic pressure activating transcytosis. The system of tolite homothetic receptors discriminating molecules of native proteins and endogenic phlogogenes on principle "right-wrong" is the basis of biological function of inherent immunity. In case of hyperglycemia and diabetes glucose becomes the minor biological "refuse". The products of chemical reaction between glucose and proteins and formation of the end products of glycosylation, components of areolar tissue become the major biological "refuse". The accumulation of products of glycosylation of collagen with cross-links in capillaries' wall increases its rigidity and makes it impossible for pericytes to implement the qualities of primary peristaltic pump. Hence the formation of hypoperfusion, condition of hypoxemia in microcirculatory section of blood circulation (muscular type arteriolae, postateriolae with muscular sphincter, metabolic capillaries) resulting in the development of microangiopathies of distal section of arterial bed. The formation of end products of glycosylation and major biological "refuse" equally are the cause of its accumulation in arteries intima as local pool of accumulation and utilization of biological "refuse" from intravascular intercellular medium during biological reaction of transcytosis and activation of formation of macroangiopathies in the form of atheromatosis of proximal section of arterial bed.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Shiriaeva
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000276:immunology* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006031:Glycosylation; D024243:HMGB1 Protein / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia; D007113:Immunity, Innate / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D051193:Toll-Like Receptors