title: Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study.
abstract: Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.
authors.affiliation: The Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Vavere
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Simon
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rochitte
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arai
authors.forename: Julie M
authors.initials: JM
authors.lastname: Miller
authors.forename: Marcello
authors.initials: M
authors.lastname: Di Carli
authors.forename: Armin
authors.initials: A
authors.lastname: Arbab-Zadeh
authors.forename: Armin A
authors.initials: AA
authors.lastname: Zadeh
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Niinuma
authors.forename: Roger
authors.initials: R
authors.lastname: Laham
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: Narinder
authors.initials: N
authors.lastname: Paul
authors.forename: John
authors.initials: J
authors.lastname: Hoe
authors.forename: Sachio
authors.initials: S
authors.lastname: Kuribyashi
authors.forename: Hajime
authors.initials: H
authors.lastname: Sakuma
authors.forename: Cesar
authors.initials: C
authors.lastname: Nomura
authors.forename: Tan Swee
authors.initials: TS
authors.lastname: Yaw
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Kofoed
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Melvin E
authors.initials: ME
authors.lastname: Clouse
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Brinker
authors.forename: Christopher
authors.initials: C
authors.lastname: Cox
authors.forename: Joao A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D002170:Canada; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation; D005060:Europe; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted; D012107:Research Design; D012720:Severity of Illness Index; D012846:Singapore; D014057:Tomography, X-Ray Computed; D014481:United States