title: The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial.
abstract: OBJECTIVE
  To evaluate the effects of intravenous (IV) tranexamic acid on blood loss and surgical field quality during functional endoscopic sinus surgery (FESS).
  
  
  METHODS
  Randomized, double-blinded, controlled trial.
  
  
  METHODS
  Operating room and postoperative recovery area of a university-affiliated hospital.
  
  
  METHODS
  84 consecutive, adult, ASA physical status 1 and 2 patients undergoing FESS.
  
  
  METHODS
  Patients were randomized to receive either IV tranexamic acid 10 mg/kg (TA group) or sterile water 0.1 mL/kg (placebo group) as a bolus dose immediately after induction of anesthesia.
  
  
  METHODS
  Amount of blood loss and bleeding and satisfaction scores were obtained from the surgeon.
  
  
  RESULTS
  Blood loss in the TA group was 184 ± 64 mL and in the placebo group, 312 ± 75 mL on average (P < 0.01). The median (range) bleeding score in the TA group was significantly lower than the placebo group [2 (1-3) vs 2.5 (2-4); P < 0.0001]. The surgeon was more satisfied with the surgical field in the TA group than the placebo group [median score: 4 (3-5) vs 3 (1-5), P < 0.001].
  
  
  CONCLUSIONS
  Intravenous tranexamic acid effectively reduces bleeding and improves the surgical field during FESS.
authors.affiliation: Department of Anesthesiology, Rasul Akram Hospital, Tehran University of Medical Science, Tehran, Iran. Alimian.mahzad@gmail.com
authors.forename: Mahzad
authors.initials: M
authors.lastname: Alimian
authors.forename: Masood
authors.initials: M
authors.lastname: Mohseni
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004311:Double-Blind Method; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012852:Sinusitis / Q000601:surgery; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid