title: Total syntheses of isonaamine C and isonaamidine E.
abstract: The total syntheses of two alkaloids isolated from a marine sponge of the Leucetta sp. have been accomplished in 6 and 7 steps starting from a 4,5-diiodoimidazole derivative. Grignard mediated halogen-metal exchange was used to install the benzyl side chain. C2 substitution was accomplished via lithiation followed by quenching with trisyl azide which provided isonaamine C after hydrogenation. Isonaamidine E was then prepared from isonaamine C via introduction of the hydantoin ring by reaction with an activated parabanic acid.
authors.affiliation: Department of Chemistry & Biochemistry, University of Texas at Arlington, Arlington, TX 76019.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Lima
authors.forename: Beatriz J
authors.initials: BJ
authors.lastname: Garcia-Barboza
authors.forename: Nicole N
authors.initials: NN
authors.lastname: Khatibi
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Lovely