title: Metformin-associated lactic acidosis (MALA): case report.
abstract: Metformin is the first-line therapy for the treatment of diabetes mellitus. In certain conditions lactic acidosis (MALA) can occur. Starting with a case report of a 62-year-old woman presenting with abdominal pain, we bring this complication to attention, describing its pathogenesis and its management. This underlines the need for thoughtful use of metformin.
authors.affiliation: Department of General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium. pieterxjan.hofkens@uzleuven.be
authors.forename: P J
authors.initials: PJ
authors.lastname: Hofkens
authors.forename: S
authors.initials: S
authors.lastname: De Winter
authors.forename: P
authors.initials: P
authors.lastname: Vanbrabant
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000628:therapy; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D006435:Renal Dialysis; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin