title: Immunomodulatory activity of polysaccharide-protein complex of longan (Dimocarpus longan Lour.) pulp.
abstract: The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg⁻¹d⁻¹ LP3 (P < 0.05). The beneficial effects of 50-200 mgkg⁻¹d⁻¹ LP3 were comparable to those of 50 mgkg⁻¹d⁻¹ ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
authors.affiliation: Key Laboratory of Functional Food, Ministry of Agriculture, Bio-Tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yi
authors.forename: Sen-Tai
authors.initials: ST
authors.lastname: Liao
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Zhang
authors.forename: Rui-Fen
authors.initials: RF
authors.lastname: Zhang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Deng
authors.forename: Bao
authors.initials: B
authors.lastname: Yang
authors.forename: Zhen-Cheng
authors.initials: ZC
authors.lastname: Wei
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002645:Chickens; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D006023:Glycoproteins / Q000737:chemistry* / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology*; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D029631:Sapindaceae / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D006023:Glycoproteins; D006460:Hemolysin Proteins; D007155:Immunologic Factors; D007376:Interleukin-2; D010936:Plant Extracts; D011134:Polysaccharides; D007371:Interferon-gamma