title: Chemiluminescence biosensors for DNA detection using graphene oxide and a horseradish peroxidase-mimicking DNAzyme.
abstract: In this communication, we demonstrate that graphene oxide (GO) greatly inhibits the peroxidatic activity of a horseradish peroxidase-mimicking DNAzyme. Combining this observation with the unique DNA/GO interactions, an ultrasensitive GO-based chemiluminescence DNA biosensing platform is developed.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Luo
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhou
authors.forename: Xia
authors.initials: X
authors.lastname: Xiang
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Xinghu
authors.initials: X
authors.lastname: Ji
authors.forename: Zhike
authors.initials: Z
authors.lastname: He
mesh_terms: D040761:Biomimetic Materials / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D021881:DNA, Catalytic / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry*; D006678:HIV; D006735:Horseradish Peroxidase / Q000378:metabolism*; D008163:Luminescent Measurements / Q000379:methods*; D008958:Models, Molecular; D008968:Molecular Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; D015345:Oligonucleotide Probes; D010087:Oxides; D006108:Graphite; D004247:DNA; D006735:Horseradish Peroxidase