title: Association of the-801G/A polymorphism of CXCL12 gene with the risk of inflammatory bowel diseases development in a Polish population.
abstract: Inflammatory bowel diseases (IBDs), mainly ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic and idiopathic inflammatory conditions of gastrointestinal tract that are immunologically mediated. Stromal cell-derived factor 1 (CXCL12) has been demonstrated to be involved in the pathophysiology of IBD.The aim of the study was to investigate whether the CXCL12 -G/A polymorphism (rs1801157) is associated to IBD in a sample of Polish population.
  
  
  METHODS
  A total of 188 patients with IBD including 103 patients with CU and 72 patients with CD and 184 controls were enrolled in the study. Both groups came from the Polish population. The G/A polymorphism of CXCL12 was determined by PCR-RFLP analysis.
  
  
  RESULTS
  There was no association between G/A polymorphism at position -801 promoter region of CXCL12 gene and increased risk of IBD. The study population was not found a difference in genotype distribution between the control group and with both CD and CU patients.
  
  
  CONCLUSIONS
  These results suggest that G/A polymorphism at position -801 promoter region of CXCL12 gene relates neither to the risk of the development of inflammatory bowel disease nor to the clinical subtypes of IBD in the Polish population. Whether this polymorphism truly contributes to disease susceptibility needs to be further addressed, and should stimulate additional studies in other populations.
authors.affiliation: Department of Clinical Chemistry and Biochemistry, Medical University, Łódź
authors.forename: Jerzy
authors.initials: J
authors.lastname: Mrowicki
authors.forename: Karolina
authors.initials: K
authors.lastname: Przybyłowska
authors.forename: Lukasz
authors.initials: L
authors.lastname: Dziki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sygut
authors.forename: Maria
authors.initials: M
authors.lastname: Wiśniewska-Jarosińska
authors.forename: Jan
authors.initials: J
authors.lastname: Chojnacki
authors.forename: Adam
authors.initials: A
authors.lastname: Dziki
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12