title: In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents β-amyloid-induced decay of long-term potentiation in rat hippocampal slices.
abstract: Addition of 200 nM β-amyloid 1-42 (Abeta) to a rat hippocampal slice impairs the induction of a long-term post-tetanic potentiation (LTP) of population spike (PS) in pyramidal neurons of the CA1 field of hippocampus. Intraperitoneal injection into the rat of the mitochondria-targeted plastoquinone derivative SkQR1 (1 µmol/kg of weight given 24 h before the slices were made) abolishes the deleterious effect of Abeta on LTP. These data demonstrate that SkQR1 therapy is able to compensate the Abeta-induced impairments of long-term synaptic plasticity in the hippocampus, which are the main cause of loss of memory and other cognitive functions associated with Alzheimer's disease.
authors.affiliation: Department of Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Pereulok Obukha 5, 105064 Moscow, Russia. kapayn@gmail.com
authors.forename: N A
authors.initials: NA
authors.lastname: Kapay
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: O V
authors.initials: OV
authors.lastname: Popova
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
authors.forename: V P
authors.initials: VP
authors.lastname: Skulachev
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar; D012235:Rhodamines / Q000008:administration & dosage*
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; D016229:Amyloid beta-Peptides; D000975:Antioxidants; D012235:Rhodamines; D010971:Plastoquinone