title: Comparison of a travoprost BAK-free formulation preserved with polyquaternium-1 with BAK-preserved travoprost in ocular hypertension or open-angle glaucoma.
abstract: OBJECTIVE
  To demonstrate that the intraocular pressure (IOP)-lowering effect of travoprost 0.004% preserved with polyquaternium-1 (travoprost benzalkonium chloride [BAK]-free) is non-inferior to that of travoprost 0.004% preserved with benzalkonium chloride (travoprost BAK) in patients with ocular hypertension or open-angle glaucoma.
  
  
  METHODS
  A total of 371 patients randomly received travoprost BAK-free (n=185) or travoprost BAK (n=186) dosed once daily in the evening for 3 months. Patients were evaluated at 9 am, 11 AM, and 4 PM at baseline, weeks 2 and 6, and month 3. Intraocular pressure was also evaluated 36 and 60 hours after the month 3 visit.
  
  
  RESULTS
  Travoprost BAK-free is non-inferior to travoprost BAK. The 95% upper confidence limits for the difference in mean IOP at month 3 (primary efficacy) were 0.5 mmHg, 0.6 mmHg, and 0.5 mmHg, at 9 AM, 11 AM, and 4 PM, respectively. Mean IOP reductions from baseline ranged from 7.6 to 8.7 mmHg in the travoprost BAK-free group and from 7.7 to 9.2 mmHg in the travoprost BAK group. At 36 and 60 hours after the last dose, mean IOP remained 6.8 mmHg and 5.7 mmHg below baseline in the travoprost BAK-free group, vs 7.3 mmHg and 6.0 mmHg in the travoprost BAK group, respectively. The safety profile of travoprost BAK-free was similar to that of travoprost BAK.
  
  
  CONCLUSIONS
  Travoprost BAK-free safely and effectively lowers IOP in eyes with open-angle glaucoma or ocular hypertension. This BAK-free formulation has comparable safety, efficacy, and duration of IOP-lowering effect to travoprost preserved with BAK. Travoprost BAK-free is an effective option for IOP reduction while avoiding BAK exposure.
authors.affiliation: Dipartimento di Scienze Otorino-Odonto-Oftalmologiche e Cervico-Facciali, Università degli Studi Di Parma, Parma, Italy. s.gandolfi@rsadvnet.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Gandolfi
authors.forename: Tania
authors.initials: T
authors.lastname: Paredes
authors.forename: Ivan
authors.initials: I
authors.lastname: Goldberg
authors.forename: Michael
authors.initials: M
authors.lastname: Coote
authors.forename: Anthony
authors.initials: A
authors.lastname: Wells
authors.forename: Lasma
authors.initials: L
authors.lastname: Volksone
authors.forename: Manju R
authors.initials: MR
authors.lastname: Pillai
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stalmans
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001548:Benzalkonium Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D003008:Cloprostenol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy / Q000503:physiopathology; D011108:Polymers / Q000008:administration & dosage* / Q000009:adverse effects; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D014065:Tonometry, Ocular; D000069557:Travoprost; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001548:Benzalkonium Compounds; D011108:Polymers; D011310:Preservatives, Pharmaceutical; D003008:Cloprostenol; C058655:polyquaternium 1; D000069557:Travoprost