title: Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population.
abstract: This study was aimed to examine the effect of vitamin C/E intake alone or combined with resistance training on antioxidant/pro-oxidant status, muscle strength and body composition in an elderly population. Fifty-seven men and women with a mean age of 65.6 ± 3.8 years were recruited and randomized in a double-blind fashion into four groups: control-placebo; resistance training (RT); vitamins C/E supplementation (AS); AS+RT. Oxidative stress status and metabolic and lipid profiles were determined at baseline and after six months. Fat-free mass and fat mass measured by DXA were similar at baseline for all groups. At six month, there was a significant difference among the groups as a function of vitamin E supplementation. Moreover, although there was no effect on pro-oxidative parameters, a significant effect on body composition was noted, but no difference was noted on strength gain. The combination of RT+AS had a positive effect on the plasma antioxidant profile but not on the pro-oxidant status.
authors.affiliation: Research Centre on Aging, University of Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Bobeuf
authors.forename: M
authors.initials: M
authors.lastname: Labonte
authors.forename: I J
authors.initials: IJ
authors.lastname: Dionne
authors.forename: A
authors.initials: A
authors.lastname: Khalil
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000187:drug effects; D000368:Aged; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D015415:Biomarkers; D001823:Body Composition / Q000187:drug effects; D001825:Body Fluid Compartments / Q000187:drug effects; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects; D055070:Resistance Training; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014810:Vitamin E; D001205:Ascorbic Acid