title: What is the evidence for using hydroxyurea for secondary stroke prevention?
abstract: A 10-year-old male patient with hemoglobin SS suffered a stroke at 7 years of age and was initially transfused at the time of presentation to lower the hemoglobin S concentration to < 30%. You are asked by the family if their child can be treated with oral hydroxyurea rather than monthly transfusions for the secondary prevention of strokes.
authors.affiliation: University of Alabama at Birmingham, Birmingham, AL, USA. JLebensburger@peds.uab.edu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lebensburger
authors.forename: Michael R
authors.initials: MR
authors.lastname: DeBaun
authors.forename: Alexis A
authors.initials: AA
authors.lastname: Thompson
mesh_terms: D001803:Blood Transfusion; D002648:Child; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D008297:Male; D055502:Secondary Prevention; D020521:Stroke / Q000188:drug therapy* / Q000517:prevention & control*
chemical_list: D006918:Hydroxyurea