title: Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from Alstonia macrophylla.
abstract: Four new linearly fused bisindole alkaloids, lumutinines A-D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Siew-Huah
authors.initials: SH
authors.lastname: Lim
authors.forename: Shin-Jowl
authors.initials: SJ
authors.lastname: Tan
authors.forename: Yun-Yee
authors.initials: YY
authors.lastname: Low
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D008296:Malaysia; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D026121:Indole Alkaloids; C475809:sarpagine