title: Rat tissue reaction to MTA FILLAPEX®.
abstract: The aim of this study was to evaluate the rat subcutaneous tissue reaction to implanted polyethylene tubes filled with mineral trioxide aggregate (MTA) FILLAPEX® compared to the reaction to tubes filled with Sealapex® or Angelus MTA® . These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Wistar rats for 7, 15, 30, 60, and 90 days. The specimens were stained with hematoxylin and eosin or Von Kossa or left unstained for examination under polarized light. Qualitative and quantitative evaluations of the reaction were performed. All materials caused moderate reactions after 7 days, which decreased with time. The reactions were moderate and similar to that evoked by the control and Sealapex® on the 15th day. MTA FILLAPEX(®) and Angelus MTA caused mild reactions beginning after 15 days. Mineralization and granulation birefringent to polarized light were observed with all materials. It was concluded that MTA FILLAPEX® was biocompatible and stimulated mineralization.
authors.affiliation: Department of Endodontics, Araçatuba School of Dentistry, University of Estadual Paulista, R. José Bonifácio 1193, Araçatuba, São Paulo, Brazil. joao@foa.unesp.br
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: Gomes-Filho
authors.forename: Simone
authors.initials: S
authors.lastname: Watanabe
authors.forename: Carolina Simonetti
authors.initials: CS
authors.lastname: Lodi
authors.forename: Luciano Tavares Angelo
authors.initials: LT
authors.lastname: Cintra
authors.forename: Mauro Juvenal
authors.initials: MJ
authors.lastname: Nery
authors.forename: José Arlindo Otoboni
authors.initials: JA
authors.lastname: Filho
authors.forename: Elói
authors.initials: E
authors.lastname: Dezan
authors.forename: Pedro Felício Estrada
authors.initials: PF
authors.lastname: Bernabé
mesh_terms: D017607:Aluminum Compounds / Q000009:adverse effects*; D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D002113:Calcification, Physiologic / Q000187:drug effects*; D017610:Calcium Compounds / Q000009:adverse effects*; D004338:Drug Combinations; D007249:Inflammation / Q000209:etiology*; D008422:Materials Testing; D008859:Microscopy, Polarization; D010087:Oxides / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000009:adverse effects*; D017640:Silicates / Q000009:adverse effects*; D013194:Staining and Labeling; D040521:Subcutaneous Tissue / Q000187:drug effects*
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate