title: Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.
abstract: Four novel benzo[j]fluoranthene derivatives, hypoxylonols C (3), D (4), E (5), and F (6), have been isolated from the mushroom Hypoxylon truncatum, together with two known benzo[j]fluoranthene derivatives, hypoxylonols A (1) and B (2). The structures were established by analysis of NMR spectroscopic data and X-ray diffraction data. Compounds 4 and 5 showed antiproliferative activity against HUVECs (human umbilical vein endothelial cells) and HUAECs (human umbilical artery endothelial cells).
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Fukai
authors.forename: Mariko
authors.initials: M
authors.lastname: Tsukada
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Miki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Kunio
authors.initials: K
authors.lastname: Takahashi
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014961:X-Ray Diffraction
chemical_list: D005449:Fluorenes; C027704:benzo(j)fluoranthene