title: Progressive constriction of the hyperautofluorescent ring in retinitis pigmentosa.
abstract: OBJECTIVE
  To evaluate the constriction of the hyperautofluorescent ring over time in patients with retinitis pigmentosa (RP).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Fourteen eyes of 14 RP patients with a hyperautofluorescent ring were studied. Ring constriction was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline and at 12-, 24-, 36-, and 48-month follow-ups. Repeat fundus autofluorescence was obtained at 12, 24, 36, and 48 months in 13, 7, 5, and 1 eyes respectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 months in 6 and 4 eyes respectively.
  
  
  RESULTS
  The external boundaries of the ring were identified along the horizontal axis in 12 eyes and along the vertical axis in 13. Internal boundaries were identified in 7 eyes. Constriction was demonstrated in all patients except 1 who demonstrated minimal expansion of the internal boundary along the horizontal axis. SD-OCT measurements showed a decrease in the IS/OS junction length.
  
  
  CONCLUSIONS
  Progressive constriction of the hyperautofluorescent ring and a concordant decrease in IS/OS junction length were observed over time.
authors.affiliation: Vitreous, Retina, Macula Consultants of New York, New York, New York 10032, USA.
authors.forename: Luiz H
authors.initials: LH
authors.lastname: Lima
authors.forename: Tomas
authors.initials: T
authors.lastname: Burke
authors.forename: Vivienne C
authors.initials: VC
authors.lastname: Greenstein
authors.forename: Chai Lin
authors.initials: CL
authors.lastname: Chou
authors.forename: Wener
authors.initials: W
authors.lastname: Cella
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Yannuzzi
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Tsang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003430:Cross-Sectional Studies; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology*; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult