title: CYP2D6 and the severity of suicide attempts.
abstract: OBJECTIVE
  Among people who die by suicide, an increased frequency of CYP2D6 active gene multiplication has been described. Therefore, the present study analyzed the relationship between the severity of the suicidal intent and CYP2D6 number of active genes among survivors.
  
  
  METHODS
  A group of 342 individuals were evaluated with Beck Suicide Intent Scale within 24 h of the failed attempt. 'Severe' suicide attempters were classified as those scoring above percentile 75 in the objective circumstances section of the Suicide Intent Scale Scale. A group of 377 healthy controls were also genotyped. results: A higher number of 'severe' suicide attempters carrying ≥2 active CYP2D6 genes as compared with the rest of the patients population (p < 0.01) or the healthy control group (p < 0.01) was found.
  
  
  CONCLUSIONS
  Considering that 'severe' suicide attempters are more likely eventually to die by suicide, CYP2D6 genetic polymorphism might be of use as a biomarker of death by suicide, which is in agreement with previous findings.
authors.affiliation: CICAB, Clinical Research Centre, Extremadura University Hospital & Medical School, Badajoz, Spain.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Peñas-Lledó
authors.forename: Hilario
authors.initials: H
authors.lastname: Blasco-Fontecilla
authors.forename: Pedro
authors.initials: P
authors.lastname: Dorado
authors.forename: Concepción
authors.initials: C
authors.lastname: Vaquero-Lorenzo
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-García
authors.forename: Adrián
authors.initials: A
authors.lastname: Llerena
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013405:Suicide
chemical_list: D019389:Cytochrome P-450 CYP2D6