title: Cardiometabolic benefits of exercise training in an experimental model of metabolic syndrome and menopause.
abstract: OBJECTIVE
  The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensive rats both submitted and not submitted to fructose overload.
  
  
  METHODS
  Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis.
  
  
  RESULTS
  The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensive rats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group.
  
  
  CONCLUSIONS
  These data suggest that the metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.
authors.affiliation: Laboratory of Translational Physiology, Nove de Julho University, Sao Paulo, Brazil.
authors.forename: Iris Callado
authors.initials: IC
authors.lastname: Sanches
authors.forename: Janaina
authors.initials: J
authors.lastname: de Oliveira Brito
authors.forename: Geórgia Orsi
authors.initials: GO
authors.lastname: Candido
authors.forename: Danielle
authors.initials: D
authors.lastname: da Silva Dias
authors.forename: Luciana
authors.initials: L
authors.lastname: Jorge
authors.forename: Maria-Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
mesh_terms: D000818:Animals; D017704:Baroreflex; D001786:Blood Glucose; D001794:Blood Pressure; D005260:Female; D005632:Fructose / Q000008:administration & dosage; D006339:Heart Rate; D008593:Menopause; D024821:Metabolic Syndrome / Q000503:physiopathology*; D023421:Models, Animal; D010052:Ovariectomy; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D001786:Blood Glucose; D005632:Fructose