title: Eosinophilic venulitis of colon presenting as ileocecal mass.
abstract: Reports of eosinophilic infiltration of the colon causing obstruction are few. It is even less common to find associated extensive intestinal venulitis, which is similar to and lumped together with so called Mesenteric Inflammatory Veno-Occlusive Disease (MIVOD) or Self-Limited Intestinal Venulitis. Eosinophilic necrotizing lymphadenitis, such as what we report here, has never been reported in association with this disease. A 41-year-old female presented with cramping lower abdominal pain, hematochezia, nausea, and vomiting. Computed tomography revealed the presence of the mass and thickening of the illeocecal wall. Endoscopy confirmed a cecal mass with surface ulceration suggestive of cecal adenocarcinoma. Patient underwent right hemicolectomy with the clinical and radiologic diagnosis of adenocarcinoma. Microscopic examination of the resected bowel showed an ulcerated mass in the cecum composed of markedly edematous tissue showing transmural eosinophilic infiltration and extensive eosinophilic and lymphocytic venulitis with and without thrombosis. This was associated with a necrotizing lymphadenitis.
authors.affiliation: Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030-3985, USA.
authors.forename: Faripour
authors.initials: F
authors.lastname: Forouhar
authors.forename: Tarun
authors.initials: T
authors.lastname: Rustagi
authors.forename: Leela
authors.initials: L
authors.lastname: Lamea
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D002432:Cecum / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D009195:Peroxidase / Q000378:metabolism; D014699:Venules / Q000473:pathology*
chemical_list: D000199:Actins; D009195:Peroxidase