title: Reprogramming of gastrointestinal cancer cells.
abstract: Cell reprogramming reverts cells to multipotent, preprogrammed states by re-establishing epigenetic markers. It can also induce considerable malignant phenotype modification. Because key events in cancer relapse and metastasis, including epithelial-mesenchymal transition phenotypes, are regulated primarily by reversible and transient epigenetic modifications rather than the accumulation of irreversible and stable genetic abnormalities, studying dynamic mechanisms regulating these biological processes is important. Transcription factors for induced pluripotent stem cells and non-coding microRNAs allow pluripotent phenotype induction. We present the current knowledge of the possible applications of cell reprogramming in reducing aggressive phenotype expression, which can induce tumor cell hibernation and maintain appropriate phenotypes, thereby minimizing relapse and metastasis after surgical resection of gastrointestinal cancer.
authors.affiliation: Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: DyahLaksmi
authors.initials: D
authors.lastname: Dewi
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Haraguchi
authors.forename: Shimpei
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kano
authors.forename: Takahito
authors.initials: T
authors.lastname: Fukusumi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ozaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sakai
authors.forename: Taroh
authors.initials: T
authors.lastname: Satoh
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D044127:Epigenesis, Genetic / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology