title: The effect of the length of the prodromal period on the metabolic control within the first 2 years in children with diabetic ketoacidosis manifestation.
abstract: OBJECTIVE
  We investigated the effects of clinical and laboratory properties at the time of the initial application of patients recently diagnosed and presenting metabolic indicators of diabetic ketoacidosis who were given disease prognoses in years 1 and 2 after discharge.
  
  
  METHODS
  A total of 94 patients admitted to Bakirkoy Maternity and Children's Diseases Training and Research Hospital with diabetic ketoacidosis and recently diagnosed with type 1 diabetes mellitus were investigated. Patient files were examined within 2 years following discharge.
  
  
  RESULTS
  All 94 study patients (53.2% male and 46.8% female) presented acidosis, ketonuria and hyperglycemia. While a moderate correlation was detected between the prodromal period and HbA(1c) values in year 1, only a slight correlation was seen in HbA(1c) values in year 2. In addition, a slight correlation was observed between the prodromal period and the number of hospitalizations due to diabetic ketoacidosis in the first year. Again, while a moderate correlation was observed between HbA(1c) values and the number of hospitalizations due to diabetic ketoacidosis in year 1, only a slight correlation was seen in year 2. The prodromal period was directly proportional to patient age.
  
  
  RESULTS
  Hospital admissions may be reduced through appropriate treatment, follow-up and metabolic control of patients with type 1 diabetes mellitus. In addition, we report a relationship between the prodromal period and HbA(1c) values in type 1 diabetes patients.
authors.affiliation: Bakirkoy Maternity and Children's Diseases Training and Research Hospital, Pediatric Clinic, MD, Istanbul, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Murat
authors.forename: Vefik
authors.initials: V
authors.lastname: Arica
authors.forename: Murat
authors.initials: M
authors.lastname: Dogan
authors.forename: Seçil Günher
authors.initials: SG
authors.lastname: Arica
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002648:Child; D002673:Child, Hospitalized / Q000706:statistics & numerical data; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000378:metabolism*; D016883:Diabetic Ketoacidosis / Q000453:epidemiology* / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human