title: Incidences and range of spontaneous findings in the lymphoid and haemopoietic system of control Charles River CD-1 mice (Crl: CD-1(ICR) BR) used in chronic toxicity studies.
abstract: The authors performed a retrospective study to determine the incidences and range of spontaneous pathology findings in the lymphoid and haemopoietic systems of control Charles River CD-1 mice (Crl: CD-1(ICR) BR). Data was collected from 2,560 mice from control dose groups (104-week and 80-week carcinogenicity studies; 13-week studies), from regulatory studies evaluated at the authors' laboratory between 2005 and 2010. Lesions of the lymphoid and hematopoietic systems were uncommon in 13-week studies but were of high incidence in the carcinogenicity studies (80- or 104-week duration). The most common finding overall was lymphoid hyperplasia within the spleen, thymus, and lymph nodes. The finding of benign lymphoid hyperplasia of the thymus is unusual in other mouse strains. The most common cause of death in the carcinogenicity studies was lymphoma. It is hoped that the results presented here will provide a useful database of incidental pathology findings in CD-1 mice on carcinogenicity studies.
authors.affiliation: Charles River Edinburgh, Scotland, United Kingdom. alys.bradley@crl.com
authors.forename: Alys
authors.initials: A
authors.lastname: Bradley
authors.forename: Sydney
authors.initials: S
authors.lastname: Mukaratirwa
authors.forename: Morven
authors.initials: M
authors.lastname: Petersen-Jones
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D015994:Incidence; D008232:Lymphoproliferative Disorders / Q000453:epidemiology* / Q000662:veterinary*; D051379:Mice; D014116:Toxicology