title: Cerebrospinal fluid IL-6, TNF-α and MCP-1 in children with acute lymphoblastic leukaemia during chemotherapy.
abstract: The aim of the study was to investigate the levels of cerebrospinal fluid (CSF) cytokines during chemotherapy of acute lymphoblastic leukaemia (ALL). Examination of 12 ALL child (6 boys and 6 girls) patients evidenced significant increases in interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) after induction treatment and significant increases in IL-6, tumour necrosis factor-α (TNF-α) and MCP-1 levels during the consolidation phase, as compared to their values at the time of diagnosis. There were no significant differences in CSF IL-6, TNF-α and MCP-1 concentrations after therapy. Our data suggest that standard ALL treatment may cause a subclinical inflammation and neurotoxicity.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Bialystok, Poland. piotrp15@wp.pl
authors.forename: P T
authors.initials: PT
authors.lastname: Protas
authors.forename: A
authors.initials: A
authors.lastname: Holownia
authors.forename: K
authors.initials: K
authors.lastname: Muszynska-Roslan
authors.forename: P
authors.initials: P
authors.lastname: Wielgat
authors.forename: M
authors.initials: M
authors.lastname: Krawczuk-Rybak
authors.forename: J J
authors.initials: JJ
authors.lastname: Braszko
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D000970:Antineoplastic Agents; D018932:Chemokine CCL2; D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha