title: Investigation of the anxiolytic effects of naringenin, a component of Mentha aquatica, in the male Sprague-Dawley rat.
abstract: This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABAA) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats per group: control, naringenin, midazolam, midazolam with naringenin, and flumazenil with naringenin. The elevated plus maze measured the behavioral components of anxiety and motor movements. Our data suggest that naringenin does not produce anxiolysis by modulation of the GABAA receptor; however, the findings indicate that naringenin decreases motor movements (P < .05).
authors.affiliation: US Army Graduate Program in Anesthesia Nursing, US Army, USA.
authors.forename: Wesley
authors.initials: W
authors.lastname: Anderson
authors.forename: Mark
authors.initials: M
authors.lastname: Barrows
authors.forename: Fernando
authors.initials: F
authors.lastname: Lopez
authors.forename: Sara
authors.initials: S
authors.lastname: Rogers
authors.forename: Adriana
authors.initials: A
authors.lastname: Ortiz-Coffie
authors.forename: David
authors.initials: D
authors.lastname: Norman
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hodges
authors.forename: Keith
authors.initials: K
authors.lastname: McDonald
authors.forename: Devon
authors.initials: D
authors.lastname: Barnes
authors.forename: Suzanne
authors.initials: S
authors.lastname: McCall
authors.forename: Johnson Arthur
authors.initials: JA
authors.lastname: Don
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ceremuga
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000378:metabolism; D001665:Binding Sites; D044950:Flavanones / Q000494:pharmacology / Q000627:therapeutic use*; D041743:Herb-Drug Interactions; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D027541:Mentha / Q000737:chemistry*; D009043:Motor Activity / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D014151:Anti-Anxiety Agents; D044950:Flavanones; D010936:Plant Extracts; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid; C005273:naringenin