title: Proliferating tricholemmal tumour: clinicopathological aspects of a case.
abstract: We report the case of a 49-year-old man who presented with an enlarging mass over his occipital scalp. The clinical impression was either a squamous cell carcinoma or an unusual adnexal tumour. A wide excision was performed with skin grafting. Gross examination revealed a large exophytic tumour mass measuring 10 cm. Histopathological examination showed a circumscribed, well-differentiated squamoproliferative lesion with a lobulated architecture. Clear cell features, pilar-type keratinisation, microcalcifications and the presence of mucinous degeneration were noted. A diagnosis of proliferating tricholemmal tumour was made. This entity incorporates a spectrum of lesions, ranging from the mostly benign proliferating tricholemmal cyst to tumours having more atypical cellular and invasive features, the latter features correlating with an increased capacity for aggressive behaviour. Management-wise, such tumours require complete excision with follow-up. As the tumours are often large in size at presentation, reconstruction is required.
authors.affiliation: Sindh Medical College, Dow University of Health Sciences, Baba-E-Urdu Road, Karachi 74200, Pakistan.
authors.forename: A A
authors.initials: AA
authors.lastname: Khoja
authors.forename: B
authors.initials: B
authors.lastname: Yan
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: E C
authors.initials: EC
authors.lastname: Cheong
authors.forename: K B
authors.initials: KB
authors.lastname: Tan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods