title: Characteristics of polysilicon wire glucose sensors with a surface modified by silica nanoparticles/γ-APTES nanocomposite.
abstract: This report investigates the sensing characteristics of polysilicon wire (PSW) glucose biosensors, including thickness characteristics and line-width effects on detection limits, linear range and interference immunity with membranes coated by micropipette/spin-coating and focus-ion-beam (FIB) processed capillary atomic-force-microscopy (C-AFM) tip scan/coating methods. The PSW surface was modified with a mixture of 3-aminopropyl-triethoxysilane (γ-APTES) and polydimethylsiloxane (PDMS)-treated hydrophobic fumed silica nanoparticles (NPs). We found that the thickness of the γ-APTES+NPs nonocomposite could be controlled well at about 22 nm with small relative standard deviation (RSD) with repeated C-AFM tip scan/coatings. The detection limit increased and linear range decreased with the line width of the PSW through the tip-coating process. Interestingly, the interference immunity ability improves as the line width increases. For a 500 nm-wide PSW, the percentage changes of the channel current density changes (ΔJ) caused by acetaminophen (AP) can be kept below 3.5% at an ultra-high AP-to-glucose concentration ratio of 600:1. Simulation results showed that the line width dependence of interference immunity was strongly correlated with the channel electrical field of the PSW biosensor.
authors.affiliation: Department of Applied Materials and Optoelectronic Engineering, National Chi Nan University, Puli, Nantou 54561, Taiwan. cclin@ncnu.edu.tw
authors.forename: Jing-Jenn
authors.initials: JJ
authors.lastname: Lin
authors.forename: Po-Yen
authors.initials: PY
authors.lastname: Hsu
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Wu
authors.forename: Jheng-Jia
authors.initials: JJ
authors.lastname: Jhuang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003198:Computer Simulation; D004560:Electricity; D005947:Glucose / Q000032:analysis*; D005949:Glucose Oxidase / Q000378:metabolism; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011437:Propylamines; D012821:Silanes / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011437:Propylamines; D012821:Silanes; D012822:Silicon Dioxide; D005949:Glucose Oxidase; D005947:Glucose; C477625:amino-propyl-triethoxysilane; D012825:Silicon