title: Thrombotic thrombocytopenic purpura and its look-alikes: a single institution experience.
abstract: At presentation, variant or "look-alike" conditions can resemble TTP. We reviewed charts of 26 consecutive patients treated for presumed TTP. Of 15 classic TTP patients, 11 were tested for ADAMTS13; all showed severe deficiency, and inhibitor levels correlated with probability of relapse. The variant TMA group consisted of 8 patients who had active clinical disorders which overlapped with TTP. Variant TMA patients had higher creatinine and worse prognosis than classic TTP patients. "Look-alike" disorders included ITP with intravascular hemolysis following administration of WinRho™, and human granulocytic anaplasmosis. These conditions had not been previously described as TTP look-alikes.
authors.affiliation: Stony Brook University Medical Center, Stony Brook, NY 11794-7300, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bellone
authors.forename: Jason
authors.initials: J
authors.lastname: Chiang
authors.forename: Tahmeena
authors.initials: T
authors.lastname: Ahmed
authors.forename: Dennis
authors.initials: D
authors.lastname: Galanakis
authors.forename: Lisa
authors.initials: L
authors.lastname: Senzel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000712:Anaplasmosis / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D003404:Creatinine