title: Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET).
abstract: In this study, we determined whether diffusion tensor imaging (DTI), a more widely available imaging modality, is as effective as α-[(11)C]methyl-l-tryptophan (AMT)-positron emission tomography (PET) in localizing epileptogenic tubers in tuberous sclerosis complex. Following that, coregistration of AMT-PET and diffusion tensor imaging scans apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in all tubers using a region-of-interest approach and were compared with AMT-PET tuber/cortex uptake ratios, which were used to differentiate between epileptogenic and nonepileptogenic tubers. Forty-three tubers, out of a total of 320 tubers, had AMT-PET uptake ratios greater than 1 and hence were classified as potentially epileptogenic. FA in epileptogenic tubers was reduced compared with the other tubers (P = .03). A significant negative correlation was observed between AMT-PET uptake ratio of epileptogenic tubers and FA values (r = -.45; P = .003). Tubers with higher AMT-PET uptake ratios corresponded well with lower FA values in tuberous sclerosis complex patients.
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.
authors.forename: Vijay Narayan
authors.initials: VN
authors.lastname: Tiwari
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Pulak K
authors.initials: PK
authors.lastname: Chakraborty
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging; D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D013223:Statistics as Topic; D014364:Tryptophan / Q000031:analogs & derivatives*; D014402:Tuberous Sclerosis / Q000150:complications
chemical_list: D002250:Carbon Radioisotopes; C028129:tryptophan methyl ester; D014364:Tryptophan