title: Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children.
abstract: BACKGROUND
  To evaluate long-term changes in corneal endothelial cell count and morphology after congenital cataract extraction and intraocular lens implantation.
  
  
  METHODS
  Cataract extraction and posterior chamber intraocular lens (IOL) implantation was performed on 54 congenital cataract patients (83 eyes). The corneal endothelial cell density (ECD), coefficient of variation (CV), hexagonality, and central corneal thickness (CCT) were measured for a retrospective analysis of long-term changes in corneal endothelial characteristics.
  
  
  RESULTS
  The mean age at the time of IOL implantation was 5.00 (3.62) years [mean (SD)], and the mean follow-up period was 8.83 (1.49) years. In a comparison of the treated and normal eyes of patients who underwent unilateral surgery, the treated eyes showed a significantly greater CCT (p < 0.05), and there was no significant difference in ECD, CV, and hexagonality (p > 0.05). In addition, there was no statistically significant difference in the ECD and CCT between the primary and secondary IOL implantation groups.
  
  
  CONCLUSIONS
  Our results did not show any significant corneal endothelial cell loss in congenital cataract patients; however, their CCTs were increased.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, 28 Yeongun-Dong,Chongro-Ku, Seoul 110-744, Korea.
authors.forename: Mi Jeung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Seong-Joon
authors.initials: SJ
authors.lastname: Kim
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D001036:Aphakia, Postcataract / Q000601:surgery*; D002386:Cataract / Q000151:congenital*; D002387:Cataract Extraction; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D055954:Corneal Endothelial Cell Loss / Q000503:physiopathology*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D019654:Lens Implantation, Intraocular; D008297:Male; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology