title: Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients.
abstract: This study was designed to determine the relationships between positron emission tomography (PET)-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular function would be significantly associated with neuropsychological functioning. Results showed that both baseline global cerebral blood flow and cerebrovascular reserve were significantly associated with global neuropsychological functioning, when controlling for age and sex. Cerebrovascular reserve was additionally associated with performance on measures of memory and attention. Additional research is needed to determine whether measures of cerebral blood flow can be used to predict cognitive decline.
authors.affiliation: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. david-moser@uiowa.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Moser
authors.forename: Laura L
authors.initials: LL
authors.lastname: Boles Ponto
authors.forename: Ivy N
authors.initials: IN
authors.lastname: Miller
authors.forename: Susan K
authors.initials: SK
authors.lastname: Schultz
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Menda
authors.forename: Stephan
authors.initials: S
authors.lastname: Arndt
authors.forename: Peggy C
authors.initials: PC
authors.lastname: Nopoulos
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D014652:Vascular Diseases / Q000150:complications / Q000473:pathology*