title: Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infection.
abstract: Cutaneous Alternaria spp. infections occur mainly in immunosuppressed patients and itraconazole is considered as the drug of choice. We report the case of a 64-year-old heart transplanted female patient with multiple cutaneous lesions caused by Alternaria infectoria. Treatment with posaconazole resulted in complete recovery. Due to lower minimal inhibitory concentrations, better distribution and less drug interactions than with itraconazole, posaconazole may become the antifungal drug to consider in the management of cutaneous infections caused by Alternaria spp. in solid organ transplant recipients.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants malades, Université Paris Descartes, 149, rue de Sèvres, 75743 Paris Cedex 15, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Rammaert
authors.forename: Claire
authors.initials: C
authors.lastname: Aguilar
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: Nicolas
authors.initials: N
authors.lastname: Noël
authors.forename: Caroline
authors.initials: C
authors.lastname: Charlier
authors.forename: Blandine
authors.initials: B
authors.lastname: Denis
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000528:Alternaria / Q000145:classification / Q000187:drug effects*; D060487:Alternariosis / Q000188:drug therapy* / Q000382:microbiology; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole