title: Multi-field-of-view SPECT is superior  to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer.
abstract: OBJECTIVE
  The aim of this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate (99mTc-HDP) in patients with prostate cancer (PCa).
  
  
  METHODS
  In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serum prostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated.
  
  
  RESULTS
  The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels <40 ng/mL.
  
  
  CONCLUSIONS
  Multi-FOV SPECT proved to be more sensitive and specific than WBS in detecting bone metastases in PCa patients.
authors.affiliation: Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland,Bellinzona, Switzerland. luca.giovanella@eoc.ch
authors.forename: Luca
authors.initials: L
authors.lastname: Giovanella
authors.forename: Massimo
authors.initials: M
authors.lastname: Castellani
authors.forename: Sergio
authors.initials: S
authors.lastname: Suriano
authors.forename: Teresa
authors.initials: T
authors.lastname: Ruberto
authors.forename: Luca
authors.initials: L
authors.lastname: Ceriani
authors.forename: Luca
authors.initials: L
authors.lastname: Tagliabue
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lucignani
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium; D017430:Prostate-Specific Antigen