title: A Machine-Learning Approach to Detecting Unknown Bacterial Serovars.
abstract: Technologies for rapid detection of bacterial pathogens are crucial for securing the food supply. A light-scattering sensor recently developed for real-time identification of multiple colonies has shown great promise for distinguishing bacteria cultures. The classification approach currently used with this system relies on supervised learning. For accurate classification of bacterial pathogens, the training library should be exhaustive, i.e., should consist of samples of all possible pathogens. Yet, the sheer number of existing bacterial serovars and more importantly the effect of their high mutation rate would not allow for a practical and manageable training. In this study, we propose a Bayesian approach to learning with a nonexhaustive training dataset for automated detection of unmatched bacterial serovars, i.e., serovars for which no samples exist in the training library. The main contribution of our work is the Wishart conjugate priors defined over class distributions. This allows us to employ the prior information obtained from known classes to make inferences about unknown classes as well. By this means, we identify new classes of informational value and dynamically update the training dataset with these classes to make it increasingly more representative of the sample population. This results in a classifier with improved predictive performance for future samples. We evaluated our approach on a 28-class bacteria dataset and also on the benchmark 26-class letter recognition dataset for further validation. The proposed approach is compared against state-of-the-art involving density-based approaches and support vector domain description, as well as a recently introduced Bayesian approach based on simulated classes.
authors.affiliation: Department of Computer and Information Science, Indiana University-Purdue University, Indianapolis, IN 46202, USA.
authors.forename: Ferit
authors.initials: F
authors.lastname: Akova
authors.forename: Murat
authors.initials: M
authors.lastname: Dundar
authors.forename: V Jo
authors.initials: VJ
authors.lastname: Davisson
authors.forename: E Daniel
authors.initials: ED
authors.lastname: Hirleman
authors.forename: Arun K
authors.initials: AK
authors.lastname: Bhunia
authors.forename: J Paul
authors.initials: JP
authors.lastname: Robinson
authors.forename: Bartek
authors.initials: B
authors.lastname: Rajwa