title: Access to quinolines through gold-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes.
abstract: A facile and general method leading to polyfunctionalized quinolines was developed. In the presence of a highly efficient combination encompassing (PPh)(3)AuCl and AgOTf, the reactions between 2-aminocarbonyls and an array of internal alkynes proceeded smoothly to afford quinoline derivatives in good to excellent yields (up to 93%).
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
authors.forename: Shuting
authors.initials: S
authors.lastname: Cai
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Bai
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000814:Aniline Compounds; D011804:Quinolines; D006046:Gold