title: A randomized study of open-flap surgery of 32 intrabony defects with and without adjunct bovine bone mineral treatment.
abstract: BACKGROUND
  Bovine bone mineral (BBM) is extensively used as a filler material in periodontal reconstructive surgery of intrabony defects. Data are mostly available on the combined use of BBM with other biomaterials. The aim of this study is to evaluate healing after open-flap debridement (OF) of intrabony periodontal defects alone or with adjunct treatment with BBM.
  
  
  METHODS
  After initial treatment, 32 patients with 32 intrabony periodontal defects participated in the study. Full-thickness flaps were raised and root surfaces and defects were debrided. Patients were then randomly assigned to treatment groups, either OF alone or combined with defect fill with BBM, and followed in a strict postoperative maintenance care program for 12 months.
  
  
  RESULTS
  At 12 months, a mean ± SE gingival recession of 1.1 ± 0.3 mm in OF and 0.9 ± 0.4 mm in BBM occurred. Probing depth reduction was 4.0 ± 0.5 mm in OF and 3.2 ± 0.7 mm in BBM. Gain in clinical attachment level was 2.8 ± 0.6 mm in OF and 2.3 ± 0.8 mm in BBM. Probing bone level was reduced by 2.7 ± 0.7 mm in OF and 1.8 ± 1.1 mm in BBM. None of the above parameters showed significant intergroup differences. In contrast, radiographic defect depth change was significantly greater in BBM (3.4 ± 2.3 mm) than in OF (1.9 ± 1.7 mm).
  
  
  CONCLUSIONS
  Both treatments resulted in improved periodontal conditions. The adjunctive use of BBM in this study did not enhance the clinical result compared to OF alone.
authors.affiliation: Department of Periodontology, The Institute for Postgraduate Dental Education, Jönköping, Sweden. christer.slotte@lj.se
authors.forename: Christer
authors.initials: C
authors.lastname: Slotte
authors.forename: Barbro
authors.initials: B
authors.lastname: Asklöw
authors.forename: Jeff
authors.initials: J
authors.lastname: Sultan
authors.forename: Ola
authors.initials: O
authors.lastname: Norderyd
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003646:Debridement / Q000379:methods; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D023861:Photography, Dental; D011446:Prospective Studies; D016300:Radiography, Bitewing; D013524:Surgical Flaps; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals