title: Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients.
abstract: OBJECTIVE
  To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan.
  
  
  METHODS
  After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method.
  
  
  RESULTS
  In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles.
  
  
  CONCLUSIONS
  AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsinchu City, Taiwan.
authors.forename: Jin-Biou
authors.initials: JB
authors.lastname: Chang
authors.forename: Nain-Feng
authors.initials: NF
authors.lastname: Chu
authors.forename: Jhu-Ting
authors.initials: JT
authors.lastname: Syu
authors.forename: An-Tsz
authors.initials: AT
authors.lastname: Hsieh
authors.forename: Yi-Ren
authors.initials: YR
authors.lastname: Hung
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D008055:Lipids; C517652:hemoglobin A1c protein, human