title: A partner evokes latent differences between Hox proteins.
abstract: Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report that a common cofactor, Exd, accentuates latent sequence specificities of all eight Hox proteins and directs binding to relevant sites across the genome.
authors.affiliation: Department of Biochemistry and The Genome Center, University of Wisconsin, Madison, Madison, WI 53706, USA. ansari@biochem.wisc.edu
authors.forename: Aseem Z
authors.initials: AZ
authors.lastname: Ansari
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Peterson-Kaufman