title: Patients with aortic stenosis referred for TAVI: treatment decision, in-hospital outcome and determinants of survival.
abstract: OBJECTIVE
  To assess treatment decision and outcome in patients referred for transcatheter aortic valve implantation (TAVI) in addition to predictive factors of mortality after TAVI.
  
  
  METHODS
  Three-centre prospective observational study including 358 patients. Endpoints were defined according to the Valve Academic Research Consortium.
  
  
  RESULTS
  Of the 358 patients referred for TAVI, TAVI was performed in 235 patients (65%), surgical aortic valve replacement (AVR) in 24 (7%) and medical therapy (MT) in 99 (28%). Reasons to decline TAVI in favour of AVR/MT were patient preference (29%), peripheral vascular disease (15%) and non-severe aortic stenosis (11%). The logistic EuroSCORE was significantly higher in patients who underwent TAVI and MT in comparison with those undergoing AVR (19 vs. 10%, p = 0.007). At 30 days, all-cause mortality and the combined safety endpoint were 9 and 24% after TAVI and 8 and 25% after AVR, respectively. All-cause mortality was significantly lower in the TAVI group compared with the MT group at 6 months, 1 year and 2 years (12% vs. 22%, 21% vs. 33% and 31% vs. 55%, respectively, p < 0.001). Multivariable analysis revealed that blood transfusion (HR: 1.19; 95% CI: 1.05-1.33), pre-existing renal failure (HR: 1.18; 95% CI: 1.06-1.33) and STS score (HR: 1.06; 95% CI: 1.02-1.10) were independent predictors of mortality at a median of 10 (IQR: 3-23) months after TAVI.
  
  
  CONCLUSIONS
  Approximately two-thirds of the patients referred for TAVI receive this treatment with gratifying short- and long-term survival. Another 7% underwent AVR. Prognosis is poor in patients who do not receive valve replacement therapy.
authors.affiliation: Department of Cardiology, Thoraxcentre, Erasmus University, Rotterdam, the Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Nuis
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authors.forename: R M
authors.initials: RM
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authors.initials: MC
authors.lastname: Jaimes
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authors.lastname: Umana
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authors.initials: WW
authors.lastname: O'Neill
authors.forename: E
authors.initials: E
authors.lastname: de Marchena
authors.forename: P P
authors.initials: PP
authors.lastname: de Jaegere