title: Lymphocytic oesophagitis: clinicopathological aspects of an emerging condition.
abstract: OBJECTIVE
  Lymphocytic oesophagitis (LyE) has been reported in small series, but no consistent clinical correlations have emerged. The authors sought to determine the prevalence of LyE in a large population and define demographic, endoscopic and clinical findings associated with this condition.
  
  
  METHODS
  In a pilot study, the authors established and disseminated criteria for the histopathological diagnosis of LyE to a group of gastrointestinal pathologists. Eighteen months later the authors reviewed cases with this diagnosis, collected demographic, clinical and endoscopic data, and compared them with patients with either eosinophilic oesophagitis (EoE) or normal oesophageal biopsies. The authors also determined the density of oesophageal lymphocytes in normal controls and in adults with established Crohn's disease.
  
  
  RESULTS
  There were 129,252 unique
  
  
  METHODS
  40,665 had normal mucosa (median age 55 years; 32% men); 3745 had EoE (median age 43 years; 66% men). A diagnosis of LyE was made in 119 patients (median age 63 years, 40% men). Dysphagia was as common in these patients as in those with EoE (53% vs 63%; ns); gastro-oesophageal reflux disease -the most common complaint in patients with normal biopsies (37%)-was low in both the LyE and the EoE groups (18% vs 19%, ns). EoE was suspected in one-third of the patients.
  
  
  CONCLUSIONS
  LyE was detected in ∼0.1% of patients with oesophageal biopsies. The clinical and endoscopic characteristics of LyE and EoE overlap considerably; however, LyE affects predominantly older women. Although the precise clinical significance of oesophageal lymphocytic infiltrates remain to be defined, their association with dysphagia and possibly motility disorders warrants further investigations.
authors.affiliation: Caris Diagnostics, 6655 North MacArthur Boulevard. Irving, TX 75039, USA.
authors.forename: Salima
authors.initials: S
authors.lastname: Haque
authors.forename: Robert M
authors.initials: RM
authors.lastname: Genta
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004941:Esophagitis / Q000453:epidemiology / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011647:Puerto Rico / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D055815:Young Adult