title: An exploratory study to determine the association between assessed facial skin aging and plasma isoprostane levels in middle-aged Japanese women.
abstract: BACKGROUND
  One of the central mechanisms of aging is hypothesized to be oxidative stress. Quantification of oxidative stress in human organ systems has been difficult. One of the best methods is using plasma isoprostane levels, which have been shown to reflect oxidative stress in multiple nondermatologic organ systems.
  
  
  OBJECTIVE
  To determine whether severity of aging of human skin is associated with plasma isoprostane levels, specifically prostaglandin F2a (PGF2a) and 8-iso-PGF2a while controlling for covariates such as body mass index, ultraviolet light exposure, diet, medication, supplement use, and stress levels.
  
  
  METHODS
  Facial skin aging assessments performed by four blinded dermatologists were correlated with plasma isoprostane levels in 46 healthy, nonsmoking Japanese women aged 45 to 60.
  
  
  RESULTS
  Individuals whose assessed skin age exceeded chronological age had mean plasma isoprostane levels of PGF2a and 8-iso-PGF2a that were higher than those whose skin age was assessed to be less than chronological age (p = .001 and .001, respectively). These results remained statistically significant when adjusted for confounding variables (8-iso-PGF2a, p = .02; PGF2a, p = .03).
  
  
  CONCLUSIONS
  Plasma isoprostanes as markers of accelerated aging of the skin merit further study.
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, Redwood City, California 94063, USA. alschang@stanford.edu
authors.forename: Anne Lynn S
authors.initials: AL
authors.lastname: Chang
authors.forename: Bharathi
authors.initials: B
authors.lastname: Lingala
authors.forename: Tiffany C
authors.initials: TC
authors.lastname: Chang
authors.forename: Dale G
authors.initials: DG
authors.lastname: Kern
authors.forename: Steve M
authors.initials: SM
authors.lastname: Wood
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Toyoda
authors.forename: Helen E
authors.initials: HE
authors.lastname: Knaggs
mesh_terms: D015415:Biomarkers / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005145:Face; D005260:Female; D006801:Humans; D028421:Isoprostanes / Q000097:blood*; D007564:Japan; D008875:Middle Aged; D012044:Regression Analysis; D015595:Skin Aging
chemical_list: D015415:Biomarkers; D028421:Isoprostanes