title: [The effect of parenteral citicoline on visual functions and life quality of patients with primary open-angle glaucoma].
abstract: The effect of nootropic drug citicoline on visual functions, perimetric indexes of static automated perimetry, morphometric characteristics of retinal tomography and life quality of patients with primary open-angle glaucoma (POAG) stage I-III and normalized intraocular pressure (IOP) was studied. 40 patients aged 46-78 years old with POAG stage I-III and normalized IOP were treated with citicoline. Among them there were 24 female and 16 male. The patients were divided into 2 equal groups--experimental and control. Patients of both groups were treated with intravenous citicoline for 10 days. The dose of citicoline in experimental group was 1000 mg/day, in control--500 mg/day. After treatment in both groups visual functions, perimetric indexes of static automated perimetry, morphometric characteristics of retinal tomography and life quality showed improvement. Citicoline has significant neuroprotective effect preventing apoptosis.
authors.forename: M A
authors.initials: MA
authors.lastname: Frolov
authors.forename: P A
authors.initials: PA
authors.lastname: Gonchar
authors.forename: V I
authors.initials: VI
authors.lastname: Barashkov
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: N S
authors.initials: NS
authors.lastname: Morozova
authors.forename: A M
authors.initials: AM
authors.lastname: Frolov
authors.forename: K A
authors.initials: KA
authors.lastname: Kazakova
mesh_terms: D000368:Aged; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007263:Infusions, Parenteral; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D018697:Nootropic Agents / Q000008:administration & dosage / Q000009:adverse effects; D011788:Quality of Life; D012720:Severity of Illness Index; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014787:Vision Tests
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline