title: Chemical constituents of the fermented broth of the ascomycete Theissenia cinerea 89091602.
abstract: One new betaenone, theissenoic acid (1), together with three new acetogenins, theissenolactones A-C (2-4, resp.), were isolated from the fermented broth of Theissenia cinerea 89091602 isolated in Taiwan. The structures of 1-4 were elucidated by spectroscopic methods. Biological tests revealed that 3 and 4 exhibited moderate growth-inhibitory activities against A549 lung cancer cell line with GI(50) values of 14.9 and 47.9 μM, respectively.
authors.affiliation: School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Liang
authors.forename: Che-Jen
authors.initials: CJ
authors.lastname: Hsiao
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Ju
authors.forename: Liang-Hsin
authors.initials: LH
authors.lastname: Lee
authors.forename: Tzong-Huei
authors.initials: TH
authors.lastname: Lee
mesh_terms: D054378:Acetogenins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013098:Xylariales / Q000737:chemistry* / Q000254:growth & development
chemical_list: C572174:2,3,7,7a-tetrahydro-3-hydroxy-7-methyl-2-(prop-1-en-1-yl)-5H-furo(3,4-b)pyran-5-one; D054378:Acetogenins; D000970:Antineoplastic Agents