title: Cyclopeptide Alkaloids from Ziziphus apetala.
abstract: Six novel Ia₃-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11β-HSD1, with IC₅₀ values of 52.0 (human) and 31.2 μg/mL (mouse).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Chang-Jiu
authors.initials: CJ
authors.lastname: Ji
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Xu
authors.forename: Jun-Ting
authors.initials: JT
authors.lastname: Fan
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.forename: Ling-Dong
authors.initials: LD
authors.lastname: Kong
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tan
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000928:Antidepressive Agents; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; D042842:11-beta-Hydroxysteroid Dehydrogenases