title: Dosimetric considerations in radioimmunotherapy and systemic radionuclide therapies: a review.
abstract: Radiopharmaceutical therapy, once touted as the "magic bullet" in radiation oncology, is increasingly being used in the treatment of a variety of malignancies; albeit in later disease stages. With ever-increasing public and medical awareness of radiation effects, radiation dosimetry is becoming more important. Dosimetry allows administration of the maximum tolerated radiation dose to the tumor/organ to be treated but limiting radiation to critical organs. Traditional tumor dosimetry involved acquiring pretherapy planar scans and plasma estimates with a diagnostic dose of intended radiopharmaceuticals. New advancements in single photon emission computed tomography and positron emission tomography systems allow semi-quantitative measurements of radiation dosimetry thus allowing treatments tailored to each individual patient.
authors.affiliation: Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.
authors.forename: Kelvin S H
authors.initials: KS
authors.lastname: Loke
authors.forename: Ajit K
authors.initials: AK
authors.lastname: Padhy
authors.forename: David C E
authors.initials: DC
authors.lastname: Ng
authors.forename: Anthony S W
authors.initials: AS
authors.lastname: Goh
authors.forename: Chaitanya
authors.initials: C
authors.lastname: Divgi