title: Bridging solubility between drug discovery and development.
abstract: Solubility has a crucial role in the success of a drug candidate. Compounds with low solubility not only cause problems for in vitro and in vivo assays, but also add significant burdens to drug development. Drug discovery and drug development often have different solubility screening requirements and methodologies have been developed to meet the needs of these different stages.
authors.affiliation: Pharmacokinetics Dynamics and Metabolism, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA. Li.Di@Pfizer.com
authors.forename: Li
authors.initials: L
authors.lastname: Di
authors.forename: Paul V
authors.initials: PV
authors.lastname: Fish
authors.forename: Takashi
authors.initials: T
authors.lastname: Mano
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility
chemical_list: D004364:Pharmaceutical Preparations