title: Effect of Vaccinium ashei reade leaf extracts on lipid metabolism in obese OLETF rats.
abstract: The effects of a hot water extract and fractional extracts from rabbiteye blueberry (Vaccinium ashei reade) leaves (BBL) on lipid metabolism were studied in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Feeding the hot water extract and fractional extracts from BBL alleviated hepatic triglyceride accumulation in the rats. Additionally, feeding with the flavonol glycoside (FG) and proanthocyanidin (PA) fractions lowered serum cholesterol levels in the obese rats. The results from measurements of the hepatic enzyme activity indicate that the hypolipidemic effects of the hot water extract and the PA fraction might be attributable to enhanced lipolysis in the liver. The reduced serum levels of C-reactive protein, an inflammatory cytokine, by the chlorogenic acid + rutin fraction and FG fraction might be associated with alleviating the metabolic abnormalities in obese rats. These results indicate that the BBL extracts, and especially FG and PA, exerted hypolipidemic effects on obese OLETF rats and suggest that an infusion of BBL can be useful as a dietary hypolipidemic component.
authors.affiliation: Department of Applied Biochemistry and Food Science, Saga University, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Koji
authors.initials: K
authors.lastname: Nagao
authors.forename: Saori
authors.initials: S
authors.lastname: Nomura
authors.forename: Bungo
authors.initials: B
authors.lastname: Shirouchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Inafuku
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hirabaru
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakahara
authors.forename: Shoko
authors.initials: S
authors.lastname: Nishizono
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
mesh_terms: D000818:Animals; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D020334:Rats, Inbred OLETF; D029796:Vaccinium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014867:Water