title: Complicated osteoporosis in progeroid syndrome: treatment with teriparatide.
abstract: Human progeroid syndromes (PSs) include a group of genetic "premature aging" diseases that affect a variety of organ systems. Bone diseases are common sequelae of patients diagnosed with PSs. Teriparatide therapy is recommended for elderly men with low bone mineral density (BMD; T-score <-2.5) and at least 1 fragility fracture who are unable to tolerate bisphosphonates. We describe a 20-yr-old patient affected by PS and severe osteoporosis complicated with femoral fracture. The patient experienced a significant improvement in lumbar spine BMD after treatment with teriparatide.
authors.affiliation: Department of Endocrinology, Getafe University Hospital, Madrid, Spain. paloma_i_b@yahoo.es
authors.forename: Paloma
authors.initials: P
authors.lastname: Iglesias Bolaños
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Guijarro de Armas
authors.forename: Soraya
authors.initials: S
authors.lastname: Civantos Modino
authors.forename: Belen
authors.initials: B
authors.lastname: Vega Piñero
authors.forename: Isabel
authors.initials: I
authors.lastname: Pavón de Paz
authors.forename: Susana
authors.initials: S
authors.lastname: Monereo Megías
mesh_terms: D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology*; D011371:Progeria / Q000150:complications*; D013577:Syndrome; D019379:Teriparatide / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide