title: Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.
abstract: Acid-sensing ion channels (ASICs) are members of the voltage-insensitive, amiloride-sensitive degenerin/epithelial Na channel family of cation channels and have been shown to mediate pain associated with tissue acidosis after inflammation or injury; however, the expression and role of ASICs in gastrointestinal tract of Henoch-Schönlein purpura (HSP) patients were still uncertain. The present study was designed to examine the expression and localization of ASICs in gastric mucosa from patients with HSP using immunochemical techniques. The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa from HSP patients with HSP. This finding suggested that ASICs may be related to the pathogenesis of gastrointestinal manifestations in patients with HSP.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Anhui Medical College, Hefei, China. yuanliping3986@sina.com
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Yuan
authors.forename: Yan
authors.initials: Y
authors.lastname: Bo
authors.forename: Gui
authors.initials: G
authors.lastname: Ming
authors.forename: Qi-lian
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D062565:Acid Sensing Ion Channels; D000138:Acidosis / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000584:Amiloride / Q000494:pharmacology; D001706:Biopsy / Q000379:methods; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005767:Gastrointestinal Diseases / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000473:pathology*; D005786:Gene Expression Regulation; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism
chemical_list: C568266:ASIC1 protein, human; D062565:Acid Sensing Ion Channels; D009419:Nerve Tissue Proteins; D015222:Sodium Channels; D000584:Amiloride