title: Oral hypertonic electrolyte-glucose/mosapride complex solution for resuscitation of burn shock in dogs.
abstract: The objective of this study is to investigate the effect of oral feeding of an electrolyte glucose mosapride solution for resuscitation in dogs with shock after a 35% TBSA full-thickness burn and the effect of mosapride on gastric emptying time. Eighteen male Beagle dogs were randomly divided into intravenous isotonic solution group, intragastric hypertonic solution group, and mosapride group after they were subjected to a 35% TBSA full-thickness flame injury. In intravenous isotonic solution group (I group), isotonic electrolyte glucose solution was given through vein with adoption of the Parkland formula. The resuscitation fluid in intragastric hypertonic solution group (H group) and mosapride group (M group) consisted of 1.8% NaCl and 5% glucose, the total fluid volume was one half of that for I group, and it was given in divided amount every 2 hours. Mosapride was added to the resuscitation fluid in mosapride group. Fluid replacement was begun 30 minutes after the injury in all the groups. Mean arterial pressure (MAP), cardiac output index (CI), intrathoracic blood volume index (ITBI), blood volume (BV), serum sodium concentration, intestinal mucosal blood flow (IMBF), gastric emptying, and serum motilin levels were determined at different time points. The urinary output of all animals was measured immediately after burn upto 360 minutes postburn. CI, ITBI, BV, and IMBF were all decreased obviously after burn. In I group and M group, CI, ITBI, BV, and IMBF were increased gradually after resuscitation, and they were significantly higher than that of H group (P < .05). MAP in all three groups was lowered significantly and then gradually recovered, showing no significant difference among groups. The urinary output in M group was similar to that in I group (P > .05), and it was higher than that in H group (P < .05). Serum sodium level in H group and M group increased in varying degrees and were markedly higher compared with the I group (P < .05). Postburn gastric emptying in H group was much more delayed (P < .05), but in M group it was much faster. Motilin level in the latter group also increased gradually postburn and was markedly higher than that of the other two groups (P < .05). At the early stage of 35% TBSA third-degree burns, gavage of 1.8% hypertonic electrolytes glucose ends in slow gastric emptying, resulting in delayed recovery from shock. When a prokinetic drug mosapride was added to the solution, gastric emptying could be accelerated and a resuscitation effect similar to that of intravenous isotonic fluid resuscitation can be achieved, while total fluid volume can be decreased by half.
authors.affiliation: Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing, People's Republic of China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Hu
authors.forename: Jiake
authors.initials: J
authors.lastname: Chai
authors.forename: Sen
authors.initials: S
authors.lastname: Hu
authors.forename: Guoyong
authors.initials: G
authors.lastname: Zhou
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Sheng
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002056:Burns / Q000150:complications*; D004195:Disease Models, Animal; D004285:Dogs; D004573:Electrolytes / Q000494:pharmacology*; D005440:Fluid Therapy / Q000379:methods*; D005947:Glucose / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology*; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D011897:Random Allocation; D012151:Resuscitation / Q000379:methods*; D012769:Shock / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D001549:Benzamides; D004573:Electrolytes; D007552:Isotonic Solutions; D009025:Morpholines; C062720:mosapride; D005947:Glucose