title: Tristetraprolin down-regulates IL-17 through mRNA destabilization.
abstract: An excess of interleukin 17 (IL-17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL-17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL-17 production in human T cell lines. Overexpression of TTP decreased the expression of IL-17. Conversely, TTP inhibition by siRNA increased IL-17 production. IL-17 mRNA contains eight AREs within its 3'UTR. TTP bound directly to the IL-17 mRNA 3'UTR at a location between the fourth and seventh AREs and enhanced decay of IL-17 transcripts. These results suggest that TTP could control IL-17-mediated inflammation.
authors.affiliation: Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.forename: Nal Ae
authors.initials: NA
authors.lastname: Yoon
authors.forename: Mai-Tram
authors.initials: MT
authors.lastname: Vo
authors.forename: Chae Won
authors.initials: CW
authors.lastname: Kim
authors.forename: Je Moon
authors.initials: JM
authors.lastname: Woo
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Cha
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Cho
authors.forename: Byung Ju
authors.initials: BJ
authors.lastname: Lee
authors.forename: Wha Ja
authors.initials: WJ
authors.lastname: Cho
authors.forename: Jeong Woo
authors.initials: JW
authors.lastname: Park
mesh_terms: D020413:3' Untranslated Regions; D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D015536:Down-Regulation; D005786:Gene Expression Regulation; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D020871:RNA Stability; D034741:RNA, Small Interfering; D013601:T-Lymphocytes / Q000378:metabolism; D051816:Tristetraprolin / Q000235:genetics / Q000378:metabolism*
chemical_list: D020413:3' Untranslated Regions; D020381:Interleukin-17; D034741:RNA, Small Interfering; D051816:Tristetraprolin; C497552:ZFP36 protein, human