title: Interleukin-6-producing dermoid cyst associated with multicentric Castleman's disease.
abstract: Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in the pathogenesis of multicentric Castleman's disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations. We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this is the first study to provide evidence of IL-6 production by CD68(+) cells in a dermoid cyst involved in MCD.
authors.affiliation: Kobe Tokushukai Hospital, Kobe, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ebara
authors.forename: Soken-Nakazawa J
authors.initials: SN
authors.lastname: Song
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mizuta
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Kenji
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Tsuneko
authors.initials: T
authors.lastname: Kamata
authors.forename: Teppei
authors.initials: T
authors.lastname: Matsumura-Nishikawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ogawa
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Soneda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Yoshizaki
mesh_terms: D000328:Adult; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications*; D003884:Dermoid Cyst / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D010386:Pelvic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D010388:Pelvis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6