title: Malondialdehyde, Bcl-2, superoxide dismutase and glutathione peroxidase may mediate the association of sonic hedgehog protein and oxidative stress in autism.
abstract: Sonic hedgehog signaling and brain-derived neurotrophic factor play a neuro-protective role against oxidative stress in autism. Sonic hedgehog also increases Bcl-2 expression and the activities of superoxide dismutase and glutathione peroxidase. The level or activity of Bcl-2, brain-derived neurotrophic factor, and the activities of superoxide dismutase and glutathione peroxidase are decreased in autism. Sonic hedgehog also decreases the production of malondialdehyde that its level is high in autism. Therefore, it is supposed that sonic hedgehog may be associated with oxidative stress in autism through other pathways too.
authors.affiliation: Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Hafez Hospital, Shiraz, Iran. ghanizad@sina.tums.ac.ir
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ghanizadeh
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D008315:Malondialdehyde / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D053823:Hedgehog Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C509239:SHH protein, human; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase