title: Safety and efficacy of daptomycin for the treatment of hospitalized adult patients in Taiwan with severe staphylococcal infections.
abstract: OBJECTIVE
  The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied.
  
  
  METHODS
  A retrospective, multicenter study was performed in Taiwan between December 2007 and June 2009. This study included adult hospitalized patients who had received intravenous daptomycin therapy for infections caused by S aureus. All patients were followed until discharge from the hospital or death.
  
  
  RESULTS
  A total of 52 patients (males, n=44; median age: 62 years) were evaluated. Infections included complicated skin and soft-tissue infections (n=14), catheter-related bacteremia (n=14), osteomyelitis and septic arthritis (n=12), endovascular infections and endocarditis (n=11), and urinary tract infections (n=1). Overall, 47 (90.4%) patients were successfully treated and their clinical symptoms were resolved. Adverse effects related to daptomycin were detected in nine patients, but none were required to discontinue daptomycin.
  
  
  CONCLUSIONS
  The results support daptomycin as an effective and safe treatment for staphylococcal infections in Taiwanese populations.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chung-Chih
authors.initials: CC
authors.lastname: Lai
authors.forename: Wang-Huei
authors.initials: WH
authors.lastname: Sheng
authors.forename: Jann-Tay
authors.initials: JT
authors.lastname: Wang
authors.forename: Chun-Hsin
authors.initials: CH
authors.lastname: Liao
authors.forename: Mao-Wang
authors.initials: MW
authors.lastname: Ho
authors.forename: Chwen-Je
authors.initials: CJ
authors.lastname: Chen
authors.forename: Der-Li
authors.initials: DL
authors.lastname: Chen
authors.forename: Ming-Uen
authors.initials: MU
authors.lastname: Chou
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Lee
authors.forename: Yee-Chun
authors.initials: YC
authors.lastname: Lin
authors.forename: Ming-Ye
authors.initials: MY
authors.lastname: Pong
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D017576:Daptomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000473:pathology; D013624:Taiwan; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin