title: Long-term assessment of contrast effects of gadofluorine M and gadofluorine P in magnetic resonance imaging of mice.
abstract: OBJECTIVE
  To investigate the long-term time course of the contrast effects after the intravenous injection of gadofluorine M or gadofluorine P in mice.
  
  
  METHODS
  Magnetic resonance images were acquired longitudinally after intravenous injection of 0.1 μmol Gd/g gadofluorine M into BALB/c mice. The contrast effects were also assessed in C57BL/6J mice injected with gadofluorine M, BALB/c mice injected with gadofluorine P, and BALB/c mice injected with a double dose of gadopentetate dimeglumine.
  
  
  RESULTS
  The injection of gadofluorine M into BALB/c mice caused prolonged contrast effects in the blood and other organs. The liver enhancement was especially long-lasting and still evident 6 days after injection. Strain-related differences in contrast kinetics of gadofluorine M were not observed between BALB/c mice and C57BL/6J mice. In comparison with gadofluorine M, clearances from the blood, liver, and kidney were more rapid and contrast enhancement in the spleen was generally lower for gadofluorine P. The enhancement in the gallbladder cavity, indicating biliary excretion, was evident only after gadofluorine P injection. Blood enhancement at 10 min was much weaker for gadopentetate dimeglumine.
  
  
  CONCLUSIONS
  Both gadofluorine M and gadofluorine P appear to be applicable to blood pool imaging and liver imaging in mice.
authors.affiliation: Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Fugeng
authors.initials: F
authors.lastname: Sheng
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kiryu
authors.forename: Makoto
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005466:Fluorocarbons; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D005704:Gallbladder / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism; D013995:Time
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D009942:Organometallic Compounds; C477144:gadofluorine; C517961:gadofluorine M; D019786:Gadolinium DTPA