title: Effect of a liver X receptor agonist on deposition and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats having a mutation in ATP-binding cassette transporter G5.
abstract: The effects were compared of T0901317, a liver X receptor agonist, on deposition in the liver and serum and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats (SHRSPs) having a missense mutation in Abcg5, which codes for ATP-binding cassette transporter (ABC) G5, with those in Wistar rats. Both strains were pair-fed for 7 d with a 0.5% plant sterol diet with or without 5 mg/kg of body weight of T0901317. The deposition of plant sterols in the liver and serum was higher in SHRSPs than in Wistar rats. A significant reduction of plant sterol deposition was observed in Wistar rats, but not in SHRSPs when T0901317 was given. Both strains were then fed for 7 d with a control diet with or without T0901317. The lymphatic absorption of plant sterols was reduced to almost half the normal level by the T0901317 treatment. However, no difference in absorption was apparent between SHRSPs and Wistar rats regardless of the T0901317 treatment. These results suggest that the plant sterol deposition in SHRSPs was not necessarily caused by the increased absorption of plant sterols.
authors.affiliation: Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
authors.forename: Tadateru
authors.initials: T
authors.lastname: Hamada
authors.forename: Mariko
authors.initials: M
authors.lastname: Kudo
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Koji
authors.initials: K
authors.lastname: Nagao
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaizumi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000042:Absorption / Q000187:drug effects; D000818:Animals; D005243:Feces; D005786:Gene Expression Regulation / Q000187:drug effects; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008074:Lipoproteins / Q000235:genetics*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D000071518:Liver X Receptors; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D020125:Mutation, Missense; D057093:Orphan Nuclear Receptors / Q000819:agonists*; D010840:Phytosterols / Q000097:blood / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D020521:Stroke / Q000235:genetics; D013449:Sulfonamides / Q000494:pharmacology*; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
chemical_list: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters; D006845:Hydrocarbons, Fluorinated; D008074:Lipoproteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010840:Phytosterols; D012333:RNA, Messenger; D013449:Sulfonamides; C480692:Abcg5 protein, rat; C423915:T0901317; D005466:Fluorocarbons; D000096926:Benzenesulfonamides