title: Bye-bye chiro-inositol - myo-inositol: true progress in the treatment of polycystic ovary syndrome and ovulation induction.
abstract: Polycystic ovary syndrome (PCOS) is a multifactorial syndrome affecting 10% of women in reproductive age. Insulin sensitizer agents are the best therapeutic option for PCOS patients; among which there is Inositol. Inositol is a polyalcohol existing as nine different stereoisomers, two of which have been shown to be insulin mediators: myo-inositol (MI) and D-chiro-inositol (DCI). So far only MI have been show to be present in the follicular fluid and in a direct comparison between MI and DCI only MI was able to improve oocyte and embryo quality. Therefore, Could we say "bye-bye D-chiro-Inositol" in the practice of clinical gynecology and reproductive medicine?
authors.affiliation: Reproductive Medicine Unit, Hera Association, Catania, Italy. gallettamarco@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Galletta
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Vaiarelli
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Roseff
mesh_terms: D005260:Female; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*
chemical_list: D007294:Inositol