title: An algorithmic approach to peripheral artery disease in hemophilia:  extrapolation of management principles from noncoagulopathic patients.
abstract: The development of peripheral artery disease (PAD), a marker for systemic atherosclerosis and ischemic risk, is an increasingly important concern in the aging hemophilia population. A growing body of data suggests that an absence or deficiency of factor VIII or factor IX may not protect against atherogenesis, implying that the prevalence of PAD in men with hemophilia (MWH) may be higher than previously believed. This article describes special considerations in PAD screening, risk-factor modification, and management in older MWH.
authors.affiliation: Penn Comprehensive Hemophilia and Thrombosis Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Patrick.Fogarty@uphs.upenn.edu
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Fogarty
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Olin
authors.forename: Craig M
authors.initials: CM
authors.lastname: Kessler
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Konkle
authors.forename: Louis M
authors.initials: LM
authors.lastname: Aledort
mesh_terms: D000368:Aged; D000465:Algorithms; D050197:Atherosclerosis / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000209:etiology* / Q000628:therapy*; D012307:Risk Factors