title: Inhibitive effects of quinestrol on male testes in Mongolian gerbils (Meriones unguiculatus).
abstract: The current study evaluated effects of quinestrol on oxidative stress and abnormal spermatogenesis for male Mongolian gerbils. Gerbils were randomly divided into multi-dose treated, single-dose treated, control groups. At 15 days after treatment antioxidant enzymes (SOD, GSH-Px) activities and T-AOC were decreased whereas the MDA concentration was significantly increased, testicular weight and seminiferous tubular areas decreased, germ cells were rarefied and showed irregular distribution in seminiferous tubules, apoptosis was pronounced among spermatocytes and spermatids, the number of dead and abnormal acrosomes of spermatozoa increased significantly in quinestrol treated groups. At 30 days following treatment the testicular histopathological changes were more severe, sperm quality and antioxidant capacity continued to decline, and multi-dose treatment produced more damage to gerbils testes compared with single-dose treatment. The physiological indicators were recovered by 60 days of treatment withdrawal. The results showed oxidative stress induced by quinestrol in relation to abnormal spermatogenesis.
authors.affiliation: College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Dazhao
authors.initials: D
authors.lastname: Shi
authors.forename: Deng
authors.initials: D
authors.lastname: Wang
authors.forename: Yongwang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology*; D005849:Gerbillinae; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D011800:Quinestrol / Q000008:administration & dosage / Q000494:pharmacology*; D055101:Semen Analysis; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D013737:Testis / Q000187:drug effects*
chemical_list: D004967:Estrogens; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D011800:Quinestrol