title: Mitral valve repair with artificial chordae: a review of its history, technical details, long-term results, and pathology.
abstract: Mitral valve repair is considered the procedure of choice for correcting mitral regurgitation in myxomatous disease, providing long-term results that are superior to those with valve replacement. The use of artificial chordae to replace elongated or ruptured chordae responsible for mitral valve prolapse and severe mitral regurgitation has been the subject of extensive experimental work to define feasibility, reproducibility, and effectiveness of this procedure. Artificial chordae made of autologous or xenograft pericardium have been replaced by chordae made of expanded polytetrafluoroethylene (PTFE), a material with the unique property of becoming covered by host fibrosa and endothelium. The use of artificial chordae made of PTFE has been validated clinically over the past 2 decades and has been an increasing component of the surgical armamentarium for mitral valve repair. This article reviews the history, details of the relevant surgical techniques, long-term results, and fate of artificial chordae in mitral reconstructive surgery.
authors.affiliation: Cardio Thoracic and Vascular Department, University of Pisa Medical School, Pisa, Italy. uberto.bortolotti@med.unipi.it
authors.forename: Uberto
authors.initials: U
authors.lastname: Bortolotti
authors.forename: Aldo D
authors.initials: AD
authors.lastname: Milano
authors.forename: Robert W M
authors.initials: RW
authors.lastname: Frater
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002815:Chordae Tendineae / Q000473:pathology; D004285:Dogs; D004868:Equipment Failure; D005976:Glutaral; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D020007:Implants, Experimental; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery*; D010496:Pericardium / Q000637:transplantation; D011138:Polytetrafluoroethylene; D016032:Randomized Controlled Trials as Topic; D013536:Suture Techniques; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene; D005976:Glutaral