title: Neuropsychological, medical and rehabilitative management of persons with multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic and disabling disease that attacks the central nervous system (CNS). The symptoms, progression, and severity of the disease are unpredictable and vary from one person to another. Major symptoms include fatigue, sensory-motor (e.g., visual disturbance, spasticity, locomotion), cognitive (e.g., decreased information processing speed, impaired memory), and psychiatric problems (e.g., depression). Although the etiology is unknown, MS is thought to be an autoimmune disease triggered by a viral or other infectious agent in genetically susceptible individuals. The CNS target of the disease is myelin, although it is now known that other aspects of the CNS such as axonal and gray matter regions are also involved.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USA. jdeluca@kesslerfoundation.org
authors.forename: John
authors.initials: J
authors.lastname: DeLuca
authors.forename: Ugo
authors.initials: U
authors.lastname: Nocentini
mesh_terms: D001007:Anxiety; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression; D018450:Disease Progression; D005221:Fatigue; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation* / Q000628:therapy; D009128:Muscle Spasticity / Q000209:etiology; D012678:Sensation Disorders / Q000209:etiology