title: Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review.
abstract: The aim of this systematic review was to collect data concerning the effects of diets containing GM maize, potato, soybean, rice, or triticale on animal health. We examined 12 long-term studies (of more than 90 days, up to 2 years in duration) and 12 multigenerational studies (from 2 to 5 generations). We referenced the 90-day studies on GM feed for which long-term or multigenerational study data were available. Many parameters have been examined using biochemical analyses, histological examination of specific organs, hematology and the detection of transgenic DNA. The statistical findings and methods have been considered from each study. Results from all the 24 studies do not suggest any health hazards and, in general, there were no statistically significant differences within parameters observed. However, some small differences were observed, though these fell within the normal variation range of the considered parameter and thus had no biological or toxicological significance. If required, a 90-day feeding study performed in rodents, according to the OECD Test Guideline, is generally considered sufficient in order to evaluate the health effects of GM feed. The studies reviewed present evidence to show that GM plants are nutritionally equivalent to their non-GM counterparts and can be safely used in food and feed.
authors.affiliation: University of Nottingham, School of Biosciences, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Snell
authors.forename: Aude
authors.initials: A
authors.lastname: Bernheim
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bergé
authors.forename: Marcel
authors.initials: M
authors.lastname: Kuntz
authors.forename: Gérard
authors.initials: G
authors.lastname: Pascal
authors.forename: Alain
authors.initials: A
authors.lastname: Paris
authors.forename: Agnès E
authors.initials: AE
authors.lastname: Ricroch
mesh_terms: D000821:Animal Feed; D000818:Animals; D030801:Animals, Genetically Modified; D004247:DNA / Q000032:analysis / Q000235:genetics; D006540:Herbicides; D030821:Plants, Genetically Modified
chemical_list: D006540:Herbicides; D004247:DNA