title: [Expression of the growth factors in the goitertransformed thyroid gland: correlation with the clinical-morphological and electron-microscopic characteristics].
abstract: The purpose of the investigation consisted in the study of morphological versions and activity of immunoselective markers in the epithelial component of the goitertransformed thyroid gland with the association of electron-microscopic changes and clinical manifestation of disease. As the primary antibodies were used mono- and polyclonal antibodies to the thyroid stimulating hormone (TSH), the vascular endothelial growth factor (VEGF) and the epidermal growth factor receptor (EGFR). It is established that the high expression of VEGF is observed in thyroid tissue, which loses sensitivity to the thyroid stimulating hormone, and vice versa. Hyperexpression of TSH, VEGF and EGFR in the nodular proliferating and adenomatous goiter indicates intensification of hyperplastic processes, the unbalance between clinical manifestation of disease and its biological potential of growth, which plays the key role in the determination of clinical prognosis of malignant potential of the nodular formation and postoperative relapse.
authors.forename: Z
authors.initials: Z
authors.lastname: Tsagareli
authors.forename: L
authors.initials: L
authors.lastname: Gogiashvili
authors.forename: E
authors.initials: E
authors.lastname: Nikobadze
authors.forename: M
authors.initials: M
authors.lastname: Dgebuadze
authors.forename: T
authors.initials: T
authors.lastname: Kvachadze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006044:Goiter, Nodular / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure*; D013972:Thyrotropin / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D013972:Thyrotropin; D066246:ErbB Receptors