title: Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors.
abstract: Biosensors have been used extensively in the scientific community for several purposes, most notably to determine association and dissociation kinetics, protein-ligand, protein-protein, or nucleic acid hybridization interactions. A number of different types of biosensors are available in the field, each with real or perceived benefits over the others. This review discusses the basic theory and operational arrangements of four commercially available types of optical biosensors: surface plasmon resonance, resonant mirror, resonance waveguide grating, and dual polarization interferometry. The different applications these techniques offer are discussed from experiments and results reported in recently published literature. Additionally, recent advancements or modifications to the current techniques are also discussed.
authors.affiliation: Department of Structural Biology, University of Pittsburgh, BST3 10017, 3501 Fifth Ave, Pittsburgh, PA 15213, USA. hnd3@pitt.edu
authors.forename: Hikmat N
authors.initials: HN
authors.lastname: Daghestani
authors.forename: Billy W
authors.initials: BW
authors.lastname: Day
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D007368:Interferometry / Q000295:instrumentation* / Q000379:methods; D055096:Optical Devices; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods