title: [The effect of potassium different concentrations on mRNA expression of protein StAR and cytochrome p-450(SCC) in human adrenocortical tissue].
abstract: The effect of different potassium concentrations on changes in steroidogenic acute regulatory protein (StAR) and cytochrome P-450(SCC) in human adrenal cortex tissue was studied. A rise in K+ concentration in incubation medium to 8.5 mM caused an increase in StAR and cytochrome P-450(SCC) mRNA level in adrenocorticocytes by 70 and 76%, respectively, compared with control. Thus, potassium ions caused an enhancement of minerocorticoid synthesis in the adrenal cortex, which is associated with mechanisms that regulate the intensity of expression of StAR and cytochrome P-450(SCC) on a transcriptional level.
authors.forename: O I
authors.initials: OI
authors.lastname: Kovzun
authors.forename: N M
authors.initials: NM
authors.lastname: Kostiuchenko
authors.forename: V M
authors.initials: VM
authors.lastname: Pushkar'ov
authors.forename: O S
authors.initials: OS
authors.lastname: Lukashenia
authors.forename: O S
authors.initials: OS
authors.lastname: Mykosha
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000235:genetics* / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D015870:Gene Expression; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D046509:Tissue Culture Techniques; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D010750:Phosphoproteins; D012333:RNA, Messenger; D000098682:Steroidogenic Acute Regulatory Protein; D002784:Cholesterol; D002786:Cholesterol Side-Chain Cleavage Enzyme; D011188:Potassium