title: Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene.
abstract: Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.
authors.affiliation: Energy Materials Laboratory, School of Chemistry, The University of East Anglia, Norwich, NR4 7TJ, UK.
authors.forename: Carl
authors.initials: C
authors.lastname: Redshaw
authors.forename: Mark R J
authors.initials: MR
authors.lastname: Elsegood
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Wright
authors.forename: Hugo
authors.initials: H
authors.lastname: Baillie-Johnson
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamato
authors.forename: Stephen
authors.initials: S
authors.lastname: De Giovanni
authors.forename: Anja
authors.initials: A
authors.lastname: Mueller
mesh_terms: D000818:Animals; D001692:Biological Transport; D047250:Calixarenes / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D010636:Phenols / Q000737:chemistry*; D014639:Vanadium / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D010636:Phenols; C121325:calix(4)arene; D014639:Vanadium; D047250:Calixarenes