title: Physical training for McArdle disease.
abstract: BACKGROUND
  McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the first few minutes of exercise are paced, a 'second wind' will occur enabling exercise to continue. This is due to mobilisation and utilisation of alternative fuel substrates. Aerobic training appears to improve work capacity by increasing cardiovascular fitness.
  
  
  OBJECTIVE
  To assess the effects of aerobic training in people with McArdle disease.
  
  
  METHODS
  We searched the Cochrane Neuromuscular Disease Group Specialized Register (11 January 2011), CENTRAL (2010, Issue 4), MEDLINE (January 1966 to January 2011) and EMBASE (January 1980 to January 2011).
  
  
  METHODS
  All randomised and quasi-randomised controlled studies of aerobic exercise training in people of all ages with McArdle disease.
  
  
  METHODS
  Two authors identified possible studies for inclusion and assessed their methodological quality. Had more than one study of sufficient methodological quality been identified we would have undertaken a meta-analysis.
  
  
  RESULTS
  There were no randomised or quasi-randomised controlled trials of aerobic training in people with McArdle disease. However, three open studies using small numbers of participants provided some evidence that aerobic training improves fitness without adverse events in people with McArdle disease.
  
  
  CONCLUSIONS
  Evidence from non-randomised studies using small numbers of patients suggest that it would be safe and worthwhile for larger controlled trials of aerobic training to be undertaken in people with McArdle disease.
authors.affiliation: MRC Centre for Neuromuscular Diseases and Dubowitz Neuromuscular Centre, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery and Great Ormond Street, PO Box 114, London, UK, WC1B 3BN.
authors.forename: Rosaline
authors.initials: R
authors.lastname: Quinlivan
authors.forename: John
authors.initials: J
authors.lastname: Vissing
authors.forename: David
authors.initials: D
authors.lastname: Hilton-Jones
authors.forename: John
authors.initials: J
authors.lastname: Buckley
mesh_terms: D015444:Exercise; D006012:Glycogen Storage Disease Type V / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans