title: [Efficacy of combined administration of ridostin and oseltamivir (tamiflu) for therapy and prophylaxis of experimental infection induced by influenza virus A (H5N1) in mice].
abstract: OBJECTIVE
  Study of possibility of treatment-prophylaxis effect increase during combined administration of ridostin and tamiflu in experiments in mice infected with highly pathogenic influenza virus strain A/chicken/Kurgan/05/2005 (H5N1).
  
  
  METHODS
  Balb/c line mice infected intranasally with influenza virus at 100 and 10 LD50 doses received ridostin and tamiflu as monopreparation or the combined variant before or after the infection. The mice were observed for 16 days, lethality rate, protection coefficient and average life span were evaluated. Virus concentration in lungs was determined by using titration in MDCK cell line.
  
  
  RESULTS
  Combined administration ofridostin and tamiflu after the infection increased survivability of the animals when compared with the control group, and reduced influenza virus concentration in lungs.
  
  
  CONCLUSIONS
  Treatment effect during combined administration of ridostin and tamiflu after influenza virus infection increased.
authors.forename: M O
authors.initials: MO
authors.lastname: Skarnovich
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: A S
authors.initials: AS
authors.lastname: Kabanov
authors.forename: N A
authors.initials: NA
authors.lastname: Mazurkova
authors.forename: E D
authors.initials: ED
authors.lastname: Danilenko
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
authors.forename: I G
authors.initials: IG
authors.lastname: Drozdov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D002460:Cell Line; D002642:Chick Embryo; D004195:Disease Models, Animal; D004285:Dogs; D004359:Drug Therapy, Combination; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D053139:Oseltamivir / Q000008:administration & dosage*; D012330:RNA, Double-Stranded / Q000008:administration & dosage*; D012331:RNA, Fungal / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; D053139:Oseltamivir