title: [Psycho- and immunomodulation properties of baclofen].
abstract: Psycho- and immunomodulator activity of GABA(B)-mimetic drug baclofen was studied on Wistar-line rats with the cyclophosphamide-induced immunosuppression and lypopolysaccharide-induced immune stress. It was established that the stimulation of GABA(B) receptors in animals with the immune system hypofunction favors regeneration of the cellular and humoral components of immune response. At the same time, under the conditions of immune hyperreactivity, the modulating effect of baclofen appears only in respect of the cell-mediated immune reaction. Moreover, it was shown that baclofen suppresses psychoemotional disorders that develop under the conditions of cyclophosphamide- and lipopolysaccharide-induced immunopathology. The results obtained in this study confirm that GABA(B) receptors participate in the processes of psycho- and immunomodulation.
authors.forename: M A
authors.initials: MA
authors.lastname: Samotrueva
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: A N
authors.initials: AN
authors.lastname: Ovcharova
authors.forename: M M
authors.initials: MM
authors.lastname: Magomedov
authors.forename: E B
authors.initials: EB
authors.lastname: Khlebtsova
mesh_terms: D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D058786:GABA-B Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007154:Immune System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology*; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000494:pharmacology; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D058786:GABA-B Receptor Agonists; D007155:Immunologic Factors; D008070:Lipopolysaccharides; D003520:Cyclophosphamide; D001418:Baclofen