title: Pegylated interferon-α2b and ribavirin combination therapy induces Hashitoxicosis followed by type 1 diabetes mellitus.
abstract: The combination of pegylated interferon-α2b (PEG-IFNα) and ribavirin (RBV) is a standard treatment for chronic hepatitis C. The case of a patient with chronic hepatitis C who developed Hashitoxicosis followed by type 1 diabetes mellitus (T1DM) with PEG-IFNα plus RBV combination therapy, but not IFNα alone, is presented.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan. hiroakiyagyu@aol.com
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yagyu
authors.forename: Kenta
authors.initials: K
authors.lastname: Okada
authors.forename: Shin
authors.initials: S
authors.lastname: Sato
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Okada
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Osuga
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Nagasaka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sugano
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced* / Q000209:etiology; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D050031:Hashimoto Disease / Q000139:chemically induced*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects; D012254:Ribavirin / Q000009:adverse effects*; D013971:Thyrotoxicosis / Q000139:chemically induced
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b