title: High-grade myofibroblastic sarcoma of inguinal region in a dog.
abstract: A subcutaneous tumor in the left inguinal region was present in an 11-year-old female bloodhound. Histopathologically, the tumor showed invasive growth and extensive necroses, and it was composed of spindle-shaped, elongated, and stellate neoplastic cells accompanied by occasional giant cells arranged in fascicular, herringbone, or irregular storiform patterns with abundant production of collagen fibers. The cytoplasm of most tumor cells was positive for vimentin, alpha-smooth muscle actin, and calponin, but was negative for desmin, smoothelin, and S-100. Furthermore, most of the tumor cells were negative for Iba1 while some tumor cells were weakly positive. Thus, this tumor was diagnosed as a high-grade myofibroblastic sarcoma according to the diagnostic criteria for human myofibroblastic sarcomas.
authors.affiliation: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Hojo
authors.forename: Takuma
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Ayako
authors.initials: A
authors.lastname: Shiraki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibutani
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Mitsumori
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D009379:Neoplasms, Muscle Tissue / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D012509:Sarcoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*