title: Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis.
abstract: Puerperal cerebral venous thrombosis (CVT) is a relatively common form of stroke in young women in India. The blood coagulation factor VII (FVII) R353Q polymorphism increases the risk for venous thrombosis. Our aim was to investigate the association of FVII R353Q polymorphism with the risk of puerperal CVT. A total of 100 women with puerperal CVT and 102 age-matched women without postpartum complications were investigated. FVII R353Q genotypes were identified using restriction fragment length polymorphism analysis. Our results showed that the homozygous FVII 353QQ genotype was present in 9% and 8% of patients and controls, respectively; and 42% of patients and 31.4% of controls had the heterozygous 353RQ genotype (odds ratio = 1.55, 95% confidence interval = 0.89-2.70; p = 0.243). Our findings suggest that the FVII R353Q polymorphism is not associated with increased risk for CVT occurring during the puerperal period in Indian women.
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neuro sciences, Post Box 2900, Hosur Road, Bangalore 560029, India.
authors.forename: T P
authors.initials: TP
authors.lastname: Kruthika-Vinod
authors.forename: Dindagur
authors.initials: D
authors.lastname: Nagaraja
authors.forename: Rita
authors.initials: R
authors.lastname: Christopher
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002550:Cerebral Veins / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D020767:Intracranial Thrombosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011644:Puerperal Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D044469:Racial Groups; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D005167:Factor VII