title: Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.
abstract: Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis of their 1D and 2D NMR spectra, circular dichroism, and mass spectrometric data, together with chemical modification. The two acetogenins display weak antiproliferative activity against the A2780 ovarian cancer, the A2058 melanoma, and the H522 lung cancer cell lines.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Dai
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: Martin W
authors.initials: MW
authors.lastname: Callmander
authors.forename: Richard
authors.initials: R
authors.lastname: Randrianaivo
authors.forename: Stephan
authors.initials: S
authors.lastname: Rakotonandrasana
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Karen
authors.initials: K
authors.lastname: TenDyke
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014197:Trees; D031046:Uvaria / Q000737:chemistry*
chemical_list: D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C046852:uvaricin