title: Ikaros and tumor suppression in acute lymphoblastic leukemia.
abstract: The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function.
authors.affiliation: Loma Linda University, Loma Linda, California, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Payne
authors.forename: Sinisa
authors.initials: S
authors.lastname: Dovat
mesh_terms: D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D051740:Ikaros Transcription Factor / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction
chemical_list: C497239:IKZF1 protein, human; D051740:Ikaros Transcription Factor