title: An oral formulation of amphotericin B attached to functionalized carbon nanotubes is an effective treatment for experimental visceral leishmaniasis.
abstract: Amphotericin B (AmB), is a highly effective antileishmanial agent used as first-line treatment in different formulations in visceral leishmaniasis endemic areas of Bihar, India. However, parenteral infusion, prolonged hospitalization, and toxicity are major hurdles. Our previous work demonstrated the efficacy and stability of functionalized carbon nanotubes as a delivery mechanism for AmB. In this study, using the hamster model, we have shown that this novel formulation of AmB can be administered orally, resulting in 99% inhibition of parasite growth following a 5-day course at 15 mg/kg body weight.
authors.affiliation: Department of Medicine, Infectious Disease Research Laboratory, Institute of Medical Sciences, Banaras Hindu University,Varanasi, India.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Prajapati
authors.forename: Kalpna
authors.initials: K
authors.lastname: Awasthi
authors.forename: Thakur Prasad
authors.initials: TP
authors.lastname: Yadav
authors.forename: Madhukar
authors.initials: M
authors.lastname: Rai
authors.forename: Onkar Nath
authors.initials: ON
authors.lastname: Srivastava
authors.forename: Shyam
authors.initials: S
authors.lastname: Sundar
mesh_terms: D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D006224:Cricetinae; D004337:Drug Carriers; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D037742:Nanotubes, Carbon; D059208:Parasite Load; D013158:Splenic Diseases / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D000666:Amphotericin B