title: Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls.
abstract: OBJECTIVE
  The methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism has been reported to be associated with myocardial infarction (MI), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of MI using a meta-analysis on the published studies.
  
  
  METHODS
  Medline, EBSCO, BIOSIS, and Cochrane Library were searched to identify eligible studies published in English before August, 2011. Data were extracted using standardized methods. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI). Begg's test was used to measure publication bias.
  
  
  RESULTS
  A total of 30 case-control studies containing 8,140 MI cases and 10,522 controls were involved in this meta-analysis. Overall, significant association was found between MTHFR C677T polymorphism and risk of MI when all studies pooled with fixed-effects model for TT vs. CT (OR = 1.183, 95% CI: 1.076-1.300). In the subgroup analysis, the same association was found in overall Caucasians (OR = 1.139, 95% CI: 1.007-1.288) and young/middle-aged (<50 years) Caucasians (OR = 1.275, 95% CI: 1.077-1.509). No associations were detected between MTHFR C677T and the risk of MI in elderly male or female Caucasians, East Asians, South Asians, and African-Americans.
  
  
  CONCLUSIONS
  Meta-analysis results suggest that the MTHFR C677T polymorphism was associated with risk of MI in young/middle-aged Caucasians. The effect of the variants on the expression levels and the possible functional role of the variants in MI should be addressed in further studies.
authors.affiliation: TEDA International Cardiovascular Hospital, Medical College, Nankai University, Tianjin, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xuan
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Bai
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: He
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)