title: Photocrosslinked co-networks from glycidylmethacrylated gelatin and poly(ethylene glycol) methacrylates.
abstract: Biopolymer-based systems with adjustable macroscopic properties that can be varied in a wide range using only small changes in chemical composition are promising candidates for biomaterial-induced autoregeneration. Glycidylmethacrylated gelatin is photopolymerized with the addition of PEG mono- or dimethacrylate to form co-networks in pH = 7.4 PBS. The degree of swelling (Q) and water uptake (H) in PBS at 37 °C are tailorable for PEGDMA co-networks (Q ≈ 250-650 vol%), while the storage modulus of swollen networks at 3 °C can be adjusted by the PEG(D)MA content (G' = 0.7-145 kPa). Indirect cytotoxicity tests on ethylene oxide sterilized films show non-toxic responses for the homonetwork and all but one PEGDMA-containing co-networks materials.
authors.affiliation: Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute of Polymer Research, Helmholtz Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Pierce
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tronci
authors.forename: Martin
authors.initials: M
authors.lastname: Rössle
authors.forename: Axel T
authors.initials: AT
authors.lastname: Neffe
authors.forename: Friedrich
authors.initials: F
authors.lastname: Jung
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002021:Buffers; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017364:Collagenases / Q000378:metabolism; D004852:Epoxy Compounds / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013552:Swine; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D002021:Buffers; D004852:Epoxy Compounds; D008689:Methacrylates; C421283:poly(ethylene glycol)-dimethacrylate; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols; D005780:Gelatin; D017364:Collagenases; C007870:glycidyl methacrylate