title: A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates.
abstract: The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the compounds was determined by (1)H and (13)C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.
authors.affiliation: Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine.
authors.forename: Danylo
authors.initials: D
authors.lastname: Kaminskyy
authors.forename: Dmytro
authors.initials: D
authors.lastname: Khyluk
authors.forename: Olexandr
authors.initials: O
authors.lastname: Vasylenko
authors.forename: Lucjusz
authors.initials: L
authors.lastname: Zaprutko
authors.forename: Roman
authors.initials: R
authors.lastname: Lesyk