title: Regenerative periodontal therapy.
abstract: Traditional treatment for loss of bone and attachment due to periodontal disease has focused around repairing the damage induced. However, over the past few decades, clinicians have begun to utilize regenerative techniques to rebuild bone, cementum and the periodontal ligament. Conventional procedures most often involve the use of barrier membranes with bone grafts that foster selective cell repopulation and regrowth of osseous structures. Since the predictability of these techniques may be limited to certain case types, pharmacologically based efforts are underway to investigate the possibility of harnessing osseous regrowth potential. Clinical research has found that proteins are potent biological mediators that promote many of the events in wound healing, and have been shown to promote bone formation in human clinical studies.
authors.affiliation: Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Daniel W K
authors.initials: DW
authors.lastname: Kao
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Fiorellini
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D003739:Dental Cementum / Q000502:physiology; D003746:Dental Enamel Proteins / Q000494:pharmacology; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D010513:Periodontal Ligament / Q000502:physiology; D010518:Periodontitis / Q000601:surgery*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology; D012038:Regeneration / Q000187:drug effects
chemical_list: D055396:Bone Morphogenetic Protein 2; D003746:Dental Enamel Proteins; D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins; C109069:enamel matrix proteins