title: [Receptors for oreksins: structure, localisation and activation mechanisms].
abstract: The review concerns morpho-functional characteristics of orexin receptors. The data on their structure, signal transduction pathways, biological effects of orexin receptors 1 or 2 depending on association with different G-proteins are presented. Localisation of orexin receptors in various CNS structures as well as in peripheral organs mediates regulation of different physiological functions by orexins. Low concentration of orexins in peripheral blood and orexin-containing cells in ganglions and internal organs suggests a possibility to activate orexin-sensitive cells distantly, paracrinely or autocrinely. The data on effects of selective or non-selective orexin receptor antagonists is analysed.
authors.forename: T V
authors.initials: TV
authors.lastname: Abramova
authors.forename: S V
authors.initials: SV
authors.lastname: Perekrest
authors.forename: K Z
authors.initials: KZ
authors.lastname: Shainidze
authors.forename: N S
authors.initials: NS
authors.lastname: Novikova
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D018013:Receptors, Neuropeptide / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; D019204:GTP-Binding Proteins