title: Combined development of thyroid gland and reproductive system benign diseases.
abstract: The aim of the study is to establish the role of endocrine disturbances in development of malignant tumors in patients with thyroid gland and reproductive system pathology.   We studied 207 patients with synchronic and metachronic development of thyroid gland and reproductive system benign tumors. The patients' average age was 35-58 years.   According to study the following aspects were determined: clinical and hormonal aspect of thyroid gland and reproductive system benign tumor disease coincidence, analyses of thyroid gland and reproductive system pre-cancer disease pathogenesis, neuroendocrine relations-like increased thyrotrophic hormone secretion causes strengthening of prolactin secretion, which depresses luteinizing hormone release and increases production of follicular stimulating hormone.   It has been proved that fibromyomas absolute hyperestrogenemia which develops during hypersecretion of follicular stimulating hormone (FSH) plays a role in etiology of uterine Gonadoliberin hypersecretion, especially follicular stimulating hormone FSH and corpus luteum deficiency is very important in development of ovarian pre-cancer and cancer diseases.
authors.affiliation: Georgian-German Specialized Oncological Clinic, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Makaridze
authors.forename: K
authors.initials: K
authors.lastname: Mardaleishvili
mesh_terms: D000328:Adult; D003338:Corpus Luteum / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006044:Goiter, Nodular / Q000473:pathology*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology; D007986:Luteinizing Hormone / Q000378:metabolism; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism / Q000473:pathology*; D010048:Ovarian Cysts / Q000145:classification / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013972:Thyrotropin / Q000378:metabolism; D014594:Uterine Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin