title: Whole-body diffusion-weighted MRI in a case of Rosai-Dorfman disease with exclusive multifocal skeletal involvement.
abstract: Rosai-Dorfman disease (RDD) is a rare disorder and usually presents with painless bilateral cervical lymphadenopathy. About 43% of RDD patients show extranodal involvement, including bones (8%). As RDD is a systemic disease, which can involve lymph nodes, bones, skin, kidneys, respiratory tract, parotid gland, orbital cavity and the central nervous system, whole-body imaging may be useful for the assessment of extent, distribution and follow-up of disease. Whole-body diffusion-weighted MRI is able to demonstrate lesions and to assess therapy response without the need for radiation or intravenous contrast agent. Here, we report a case of a 15-year-old boy with primary skeletal RDD without lymphadenopathy, who was staged and followed by whole-body diffusion-weighted MRI.
authors.affiliation: Centre for Paediatrics and Adolescent Medicine and Dermatology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Rittner
authors.forename: Ulrich
authors.initials: U
authors.lastname: Baumann
authors.forename: Florian
authors.initials: F
authors.lastname: Laenger
authors.forename: Dagmar
authors.initials: D
authors.lastname: Hartung
authors.forename: Herbert
authors.initials: H
authors.lastname: Rosenthal
authors.forename: Katja
authors.initials: K
authors.lastname: Hueper
mesh_terms: D000293:Adolescent; D001847:Bone Diseases / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008297:Male; D051598:Whole Body Imaging / Q000379:methods*