title: The level of orally ingested vitamin C affected the expression of vitamin C transporters and vitamin C accumulation in the livers of ODS rats.
abstract: We investigated the effects of vitamin C administration on vitamin C-specific transporters in ODS/ShiJcl-od/od rat livers. The vitamin C-specific transporter levels increased in the livers of the rats not administered vitamin C and decreased in the livers of those administered vitamin C at 100 mg/d, indicating that these transporter levels can be influenced by the amount of vitamin C administered.
authors.affiliation: Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sone
authors.forename: Etsuko
authors.initials: E
authors.lastname: Ueta
authors.forename: Satoru
authors.initials: S
authors.lastname: Kodama
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sannoumaru
authors.forename: Noriko
authors.initials: N
authors.lastname: Miyake
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kondo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inagaki
authors.forename: Eiji
authors.initials: E
authors.lastname: Namba
authors.forename: Tadao
authors.initials: T
authors.lastname: Kurata
authors.forename: Emiko
authors.initials: E
authors.lastname: Suzuki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D060347:Sodium-Coupled Vitamin C Transporters / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; C555166:Slc23a1 protein, rat; C555167:Slc23a2 protein, rat; D060347:Sodium-Coupled Vitamin C Transporters; D001205:Ascorbic Acid