title: Candida albicans dimorphism as a therapeutic target.
abstract: The ability to switch between yeast and hyphal growth forms (dimorphism) is one of the most discussed and best investigated virulence attributes of the human pathogenic fungus Candida albicans. Both morphological forms seem to be important for virulence and have distinct functions during the different stages of disease development, including adhesion, invasion, damage, dissemination, immune evasion and host response. In this review, we will provide an overview of the known and potential roles of C. albicans dimorphism and will discuss the potential benefit of drugs that can inhibit the morphological transition.
authors.affiliation: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute Jena, Beutenbergstraße 11a, D-07745, Jena, Germany.
authors.forename: Ilse D
authors.initials: ID
authors.lastname: Jacobsen
authors.forename: Duncan
authors.initials: D
authors.lastname: Wilson
authors.forename: Betty
authors.initials: B
authors.lastname: Wächtler
authors.forename: Sascha
authors.initials: S
authors.lastname: Brunke
authors.forename: Julian R
authors.initials: JR
authors.lastname: Naglik
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hube
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy*; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D025301:Hyphae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D014774:Virulence; D037521:Virulence Factors
chemical_list: D037521:Virulence Factors