title: Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase.
abstract: The (pro)renin receptor (P)RR is a receptor for renin and prorenin, not only allowing local production of angiotensin I from angiotensinogen, but also inducing intracellular signaling. Intriguingly, (P)RR is also called ATP6AP2 because a (P)RR fragment was demonstrated to be associated with vacuolar-type H+-ATPase (V-ATPase), which is of importance for the maintenance of intracellular pH. Recent studies implicate that deletion of (P)RR results in the dysfunction of V-ATPase, suggesting that the (P)RR is essential for its role as a proton pump. Furthermore, the novel function of (P)RR as an adaptor protein between the Wnt receptor complex and the V-ATPase was discovered. Thus, (P)RR is a multi-functional molecule with functions beyond renin and prorenin. This review focuses on the current knowledge and issues of (P)RR and V-ATPase.
authors.affiliation: Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women's Medical University, Japan. atzichi@endm.twmu.ac.jp
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Ichihara
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kinouchi
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D025262:Vacuolar Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D025262:Vacuolar Proton-Translocating ATPases; D000093342:Prorenin Receptor