title: NutriTRAILomics in prostate cancer: time to have two strings to one's bow.
abstract: The astonishing development of broad genomics and proteomics tools have catalyzed a new era in both therapeutic interventions and nutrition in prostate cancer. The terms pharmacogenomics and nutrigenomics have been derived out of their genetic forbears as large-scale genomics technologies have been established in the last decade. It is unquestionable that rationale of both disciplines is to individualize or personalize medicine and food and nutrition, and eventually health, by tailoring the drug or the food to the individual genotype. The purpose of this review is to significantly inspect results from current research concerning the mechanisms of action of phytonutrients and potential effects on prostate cancer. Substantial emerging data supports the synergistic adiministration of nutraceuticals with TRAIL in prostate cancer progression to circumvent TRAIL refractoriness. Nonetheless, developing novel scientific methods for discovery, validation, characterization and standardization of these multicomponent phyto-therapeutics is vital to their recognition into mainstream medicine. The key to interpret a personalized response is a greater comprehension of nutrigenomics, proteomics and metabolomics.
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan. ammadahmad638@yahoo.com
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Aamir
authors.initials: A
authors.lastname: Rana
authors.forename: Asma M
authors.initials: AM
authors.lastname: Riaz
authors.forename: Ammara
authors.initials: A
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.forename: Sara
authors.initials: S
authors.lastname: Javed
authors.forename: Shahzeray
authors.initials: S
authors.lastname: Mukhtar
authors.forename: Sehrish
authors.initials: S
authors.lastname: Minhaj
authors.forename: Javeria Rafique
authors.initials: JR
authors.lastname: Rao
authors.forename: Javairia
authors.initials: J
authors.lastname: Rajpoot
authors.forename: Rafia
authors.initials: R
authors.lastname: Amber
authors.forename: Fiza Asif
authors.initials: FA
authors.lastname: Javed
authors.lastname: Waqar-Un-Nisa
authors.forename: Reema
authors.initials: R
authors.lastname: Khanum
authors.forename: Shahzad
authors.initials: S
authors.lastname: Bhatti
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008954:Models, Biological; D054647:Nutrigenomics; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand