title: Nutritional status of children and young adults with Ewing sarcoma or osteosarcoma at diagnosis and during multimodality therapy.
abstract: OBJECTIVE
  Objective of our study was to evaluate the nutritional status and growth of children and adolescents with common malignancies of the musculoskeletal system at diagnosis, and undergoing multimodality therapy.
  
  
  METHODS
  A retrospective analysis of data from 2001 to 2009 was conducted. Hospital charts were used as a source of clinical data. Primary endpoint of the analyses was to identify variations in anthropometric parameters at diagnosis and during the first 2 years of follow-up in children and adolescents with osteosarcoma or Ewing sarcoma. Factors contributing to disorders of growth in this population were sought.
  
  
  RESULTS
  A total of 139 children were registered, 62 with Ewing sarcoma and 77 with osteosarcoma. At diagnosis 72.7% of all patients were classified as adequately nourished (BMI 5th to <85th percentiles). During treatment all anthropometric parameters were markedly reduced (P < 0.001) in both groups with extreme changes in body weight from -30% to +44%. This was pronounced in children affected by osteosarcoma (P < 0.05). During follow-up, recovery of body weight was noted in both groups. Height Z-scores remained low (P < 0.001) in comparison to the general population. After the observation period 43.4% of the children with osteosarcoma and 25.5% of the patients with Ewing sarcoma demonstrated an altered body mass.
  
  
  CONCLUSIONS
  Pediatric patients with Ewing sarcoma or osteosarcoma are at an increased risk for developing malnutrition, in the form of either over- or underweight during multimodality therapy. Early recognition of abnormal body mass is required to prevent and to treat long-term comorbidities caused by malnutrition.
authors.affiliation: Department of Pediatrics, University Children's Hospital Münster, Münster, Germany.
authors.forename: Retno D
authors.initials: RD
authors.lastname: Tenardi
authors.forename: Michael C
authors.initials: MC
authors.lastname: Frühwald
authors.forename: Heribert
authors.initials: H
authors.lastname: Jürgens
authors.forename: Dorijn
authors.initials: D
authors.lastname: Hertroijs
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Bauer
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D049628:Body Size; D001859:Bone Neoplasms / Q000150:complications / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006128:Growth; D006801:Humans; D007223:Infant; D008297:Male; D044342:Malnutrition / Q000209:etiology; D009752:Nutritional Status; D012516:Osteosarcoma / Q000150:complications / Q000628:therapy*; D012512:Sarcoma, Ewing / Q000150:complications / Q000628:therapy*; D015430:Weight Gain; D015431:Weight Loss; D055815:Young Adult