title: Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide.
abstract: Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Ota
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeiri
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tachibana
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
mesh_terms: D000818:Animals; D019921:Biotinylation; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D019169:Jurkat Cells; D008070:Lipopolysaccharides / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008956:Models, Chemical; D015335:Molecular Probes / Q000737:chemistry; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis / Q000494:pharmacology*; D013997:Time Factors
chemical_list: C573776:3-((dodecylthiocarbonyl)methyl)glutarimide; D008070:Lipopolysaccharides; D015335:Molecular Probes; D016328:NF-kappa B; D010881:Piperidones; D009569:Nitric Oxide; C008497:9-methylstreptimidone; C007864:glutarimide