title: Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus.
abstract: To describe a case of herpetic keratitis after corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A for progressive keratoconus. A 31-year-old woman with rapidly progressive keratoconus in the left eye was treated with CXL. Four days postoperatively, a dendritic ulcer developed in the treated eye. The diagnosis was confirmed with polymerase chain reaction analysis of the corneal swab for herpes simplex. The patient had no prior history of herpetic eye disease or cold sores. The keratitis resolved in 10 days with treatment. At 1 month, the visual acuity was stable, but a mild superficial opacity was noted. Herpetic keratitis can be induced by CXL even in patients with no history of previous herpetic eye disease. Early diagnosis and proper treatment can facilitate successful management of this rare but important complication.
authors.affiliation: Department of Ophthalmology, Kahramanmaras State Hospital, Yörükselim Mah. Gazi Mustafa Kuscu Cad., Merkez, 46100, Kahramanmaras, Turkey. ozturk.nilay@gmail.com
authors.forename: Nilay
authors.initials: N
authors.lastname: Yuksel
authors.forename: Kamil
authors.initials: K
authors.lastname: Bilgihan
authors.forename: Ahmet M
authors.initials: AM
authors.lastname: Hondur
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016849:Keratitis, Herpetic / Q000139:chemically induced* / Q000378:metabolism; D007640:Keratoconus / Q000188:drug therapy* / Q000821:virology*; D017319:Photosensitizing Agents / Q000009:adverse effects; D012256:Riboflavin / Q000009:adverse effects*; D014467:Ultraviolet Therapy / Q000009:adverse effects*
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin