title: TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support.
abstract: As the relevant literature and the number of experiments increase at a super linear rate, databases that curate and collect experimentally verified microRNA (miRNA) targets have gradually emerged. These databases attempt to provide efficient access to this wealth of experimental data, which is scattered in thousands of manuscripts. Aim of TarBase 6.0 (http://www.microrna.gr/tarbase) is to face this challenge by providing a significant increase of available miRNA targets derived from all contemporary experimental techniques (gene specific and high-throughput), while incorporating a powerful set of tools in a user-friendly interface. TarBase 6.0 hosts detailed information for each miRNA-gene interaction, ranging from miRNA- and gene-related facts to information specific to their interaction, the experimental validation methodologies and their outcomes. All database entries are enriched with function-related data, as well as general information derived from external databases such as UniProt, Ensembl and RefSeq. DIANA microT miRNA target prediction scores and the relevant prediction details are available for each interaction. TarBase 6.0 hosts the largest collection of manually curated experimentally validated miRNA-gene interactions (more than 65,000 targets), presenting a 16.5-175-fold increase over other available manually curated databases.
authors.affiliation: IMIS Institute, 'Athena' Research Center, 11524 Athens, Greece.
authors.forename: Thanasis
authors.initials: T
authors.lastname: Vergoulis
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vlachos
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Alexiou
authors.forename: George
authors.initials: G
authors.lastname: Georgakilas
authors.forename: Manolis
authors.initials: M
authors.lastname: Maragkakis
authors.forename: Martin
authors.initials: M
authors.lastname: Reczko
authors.forename: Stefanos
authors.initials: S
authors.lastname: Gerangelos
authors.forename: Nectarios
authors.initials: N
authors.lastname: Koziris
authors.forename: Theodore
authors.initials: T
authors.lastname: Dalamagas
authors.forename: Artemis G
authors.initials: AG
authors.lastname: Hatzigeorgiou
mesh_terms: D057225:Data Mining; D030561:Databases, Nucleic Acid; D004194:Disease / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs