title: Dietary supplementation with omega-3-PUFA-rich fish oil reduces signs of food allergy in ovalbumin-sensitized mice.
abstract: We investigated the effect of dietary supplementation with n-3 PUFA (fish oil source) in an experimental model of food allergy. Mice were sensitized (allergic group) or not (nonallergic group) with OVA and were fed with OVA diet to induce allergy signals. Mice were fed with regular diet in which 7% of lipid content was provided by soybean (5% of n-3 PUFA) or fish (25% of n-3 PUFA) oil. Allergic group mice had increased serum levels of antiovalbumin IgE and IgG1 and changes in small intestine, characterized by an increased edema, number of rolling leukocytes in microcirculation, eosinophil infiltration, mucus production, and Paneth cell degranulation, in comparison to non-allergic group. All these inflammatory parameters were reduced in mice fed high-n-3-PUFA diet. Our data together suggest that diet supplementation with n-3 PUFA from fish oil may consist of a valid adjuvant in food allergy treatment.
authors.affiliation: Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Olívia Gonçalves
authors.initials: OG
authors.lastname: de Matos
authors.forename: Sylvia Stella
authors.initials: SS
authors.lastname: Amaral
authors.forename: Pedro Elias Marques
authors.initials: PE
authors.lastname: Pereira da Silva
authors.forename: Denise Alves
authors.initials: DA
authors.lastname: Perez
authors.forename: Débora Moreira
authors.initials: DM
authors.lastname: Alvarenga
authors.forename: Adaliene Versiani Matos
authors.initials: AV
authors.lastname: Ferreira
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Alvarez-Leite
authors.forename: Gustavo Batista
authors.initials: GB
authors.lastname: Menezes
authors.forename: Denise Carmona
authors.initials: DC
authors.lastname: Cara
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D005512:Food Hypersensitivity / Q000276:immunology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology*
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010047:Ovalbumin