title: Disseminated histoplasmosis mimicking secondary syphilis.
abstract: A 34-year-old, HIV-positive man living in Texas presented with a 2-week history of fever, malaise, myalgias, oral ulcers, and papules on his chest, back, face, and extremities, including the palms. Initially secondary syphilis was suspected. However, RPR was negative. Histopathologic examination revealed a lymphocytic infiltrate with numerous intra-histiocytic fungal organisms. GMS and PAS stains were positive, consistent with the diagnosis of histoplasmosis. We report a case of disseminated histoplasmosis clinically mimicking secondary syphilis.
authors.affiliation: Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Tony A
authors.initials: TA
authors.lastname: Pastor
authors.forename: Maura J
authors.initials: MJ
authors.lastname: Holcomb
authors.forename: Kiran
authors.initials: K
authors.lastname: Motaparthi
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Grekin
authors.forename: Sylvia
authors.initials: S
authors.lastname: Hsu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D003453:Cryptococcosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D019353:Endemic Diseases; D006529:Hepatomegaly / Q000209:etiology; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D013587:Syphilis / Q000175:diagnosis*; D013781:Texas / Q000453:epidemiology
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B