title: Decreased activation and increased lateralization in brain functioning for selective attention and response inhibition in adolescents with spina bifida.
abstract: We used functional magnetic resonance imaging to evaluate functional activity in the brain of adolescents with spina bifida when performing selective attention and response inhibition tasks. We then compared the results to that of age-matched controls. Our results showed that adolescents with spina bifida had decreased frontal and superior parietal activation and more apparently low involvement of left brain hemisphere during these tasks. Our results indicated activation deficits and possibly abnormal functional organization in adolescents with spina bifida and associated pathologies such as hydrocephalus.
authors.affiliation: Department of Radiology, Arkansas Children's Hospital, Little Rock, USA. ouxiawei@uams.edu
authors.forename: Xiawei
authors.initials: X
authors.lastname: Ou
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Snow
authors.forename: Amy K
authors.initials: AK
authors.lastname: Byerley
authors.forename: John J
authors.initials: JJ
authors.lastname: Hall
authors.forename: Charles M
authors.initials: CM
authors.lastname: Glasier
mesh_terms: D000293:Adolescent; D001288:Attention; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D056344:Executive Function; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D016135:Spinal Dysraphism / Q000503:physiopathology*; D013647:Task Performance and Analysis