title: Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope.
abstract: BACKGROUND
  Passive video capsule endoscopy is the criterion standard for small-bowel exploration but cannot be used for the large gastric cavity. We report the first blinded comparative clinical trial in humans comparing a magnetically guided capsule endoscope (MGCE) and a conventional high-definition gastroscope.
  
  
  OBJECTIVE
  To assess the potential of gastric examination with a guided capsule.
  
  
  METHODS
  Blinded, nonrandomized comparative study.
  
  
  METHODS
  Single endoscopy center.
  
  
  METHODS
  The trial involved 61 patients included in a blinded capsule and gastroscopy comparative study. MGCE examination was performed 24 hours after patients had undergone gastroscopy. To remove food residue or mucus, patients drank 900 mL of water in 2 portions. Then to provide the air-water interface required by the guidance system, they drank 400 mL of water at 35°C.
  
  
  RESULTS
  Visualization of the gastric pylorus, antrum, body, fundus, and cardia was evaluated as complete in 88.5%, 86.9%, 93.4%, 85.2%, and 88.5% of patients, respectively. Of gastric lesions, 58.3% were detected by both gastroscopy and MGCE at immediate assessment and review of recorded data. Capsule examination missed 14 findings and gastroscopy missed 31 findings seen with MGCE. Overall diagnostic yield was similar for both modalities.
  
  
  CONCLUSIONS
  Pilot study.
  
  
  CONCLUSIONS
  Diagnostic results were similar for the 2 methods. After some technical difficulties related to gastric expansion or presence of mucus had been overcome, this study opened a new field for noninvasive gastric examination in countries where high gastric cancer incidence demands a screening tool.
authors.affiliation: Hepato-Gastroenterology Department, Institut Arnault Tzanck, St. Laurent du Var, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Rey
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata
authors.forename: Naoki
authors.initials: N
authors.lastname: Hosoe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohtsuka
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ogata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aihara
authors.forename: Ileana
authors.initials: I
authors.lastname: Pangtay
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Shin-ei
authors.initials: SE
authors.lastname: Kudo
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000368:Aged; D053705:Capsule Endoscopes; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D020699:Gastroscopes; D005773:Gastroscopy / Q000295:instrumentation*; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016037:Single-Blind Method; D013270:Stomach / Q000473:pathology*; D013272:Stomach Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult