title: DiseaseMeth: a human disease methylation database.
abstract: DNA methylation is an important epigenetic modification for genomic regulation in higher organisms that plays a crucial role in the initiation and progression of diseases. The integration and mining of DNA methylation data by methylation-specific PCR and genome-wide profiling technology could greatly assist the discovery of novel candidate disease biomarkers. However, this is difficult without a comprehensive DNA methylation repository of human diseases. Therefore, we have developed DiseaseMeth, a human disease methylation database (http://bioinfo.hrbmu.edu.cn/diseasemeth). Its focus is the efficient storage and statistical analysis of DNA methylation data sets from various diseases. Experimental information from over 14,000 entries and 175 high-throughput data sets from a wide number of sources have been collected and incorporated into DiseaseMeth. The latest release incorporates the gene-centric methylation data of 72 human diseases from a variety of technologies and platforms. To facilitate data extraction, DiseaseMeth supports multiple search options such as gene ID and disease name. DiseaseMeth provides integrated gene methylation data based on cross-data set analysis for disease and normal samples. These can be used for in-depth identification of differentially methylated genes and the investigation of gene-disease relationship.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lv
authors.forename: Hongbo
authors.initials: H
authors.lastname: Liu
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Su
authors.forename: Xueting
authors.initials: X
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Boyan
authors.initials: B
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Xiao
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D019175:DNA Methylation; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D005796:Genes; D023281:Genomics; D006801:Humans; D011401:Promoter Regions, Genetic; D012984:Software