title: Triply triggered doxorubicin release from supramolecular nanocontainers.
abstract: The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
authors.forename: Jesús
authors.initials: J
authors.lastname: del Barrio
authors.forename: Pearl Pei Chern
authors.initials: PP
authors.lastname: Toh
authors.forename: Tung-Chun
authors.initials: TC
authors.lastname: Lee
authors.forename: Dezhi
authors.initials: D
authors.lastname: Jiao
authors.forename: Urs
authors.initials: U
authors.lastname: Rauwald
authors.forename: Eric A
authors.initials: EA
authors.lastname: Appel
authors.forename: Oren A
authors.initials: OA
authors.lastname: Scherman
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000494:pharmacology; D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D008689:Methacrylates; D009757:Nylons; D011108:Polymers; C407037:poly(2-(dimethylamino)ethyl methacrylate); C052970:poly-N-isopropylacrylamide; D004317:Doxorubicin