title: Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients.
abstract: Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34(+)/CD133(+)/VEGFR-2(+)) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.
authors.forename: Hyun Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Kwang Joon
authors.initials: KJ
authors.lastname: Kim
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Moon
authors.forename: Hye-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Chae
authors.forename: Hyuk-Jae
authors.initials: HJ
authors.lastname: Chang
authors.forename: Eun Seok
authors.initials: ES
authors.lastname: Kang
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Byung-Wan
authors.initials: BW
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases / Q000453:epidemiology; D016022:Case-Control Studies; D002452:Cell Count; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000601:surgery; D042783:Endothelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000706:statistics & numerical data*; D013234:Stem Cells / Q000473:pathology*