title: Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience.
abstract: The aim of the present study is to examine all cases of intraosseous benign ameloblastomas treated between 1970 and 2010 in a single institution and to look for a possible correlation between the histopathological aspects and the demographical and clinical parameters, as well as the treatment outcome. The data of a total number of 44 patients were retrieved from the records. Nine patients were excluded because of doubt about the correct diagnosis (8 patients) or because of an extra-osseous presentation (1 patient).  No statistically significant differences were found between the histopathological (sub)types of ameloblastomas and the demographical and clinical parameters, nor between the histopathological (sub)types and treatment outcome. Of the 28 patients treated by enucleation, in 17 patients one or more recurrences occurred, with no significant predilection for any histopathological (sub)type, including the unicystic type. There were no significant differences in the recurrence rate after enucleation in patients below and above the age of 20 years either. In six out of 17 patients with a recurrence, the recurrent lesion showed a different histopathological subtype than was encountered in the primary. In two cases a change from solid/multicystic to desmoplastic ameloblastomas was noticed.  In conclusion, the current histopathological classification of benign intraosseous ameloblastoma does not seem to have clinical relevance with the possible exception of the luminal unicystic ameloblastoma that has been removed in toto, unfragmented. Since no primary desmoplastic ameloblastomas were encountered in the present study no further comments can be made on this apparently rare entity.
authors.affiliation: VU University Medical Center (VUmc)/Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral & Maxillofacial Surgery/Oral Pathology, Amsterdam, The Netherlands.
authors.forename: Doenja
authors.initials: D
authors.lastname: Hertog
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bloemena
authors.forename: Irene H A
authors.initials: IH
authors.lastname: Aartman
authors.forename: Isaäc
authors.initials: I
authors.lastname: van-der-Waal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult