title: Diffusion-prepared fast imaging with steady-state free precession (DP-FISP): a rapid diffusion MRI technique at 7 T.
abstract: Diffusion MRI is a useful imaging technique with many clinical applications. Many diffusion MRI studies have utilized echo-planar imaging (EPI) acquisition techniques. In this study, we have developed a rapid diffusion-prepared fast imaging with steady-state free precession MRI acquisition for a preclinical 7T scanner providing diffusion-weighted images in less than 500 ms and diffusion tensor imaging assessments in ∼1 min with minimal image artifacts in comparison with EPI. Phantom apparent diffusion coefficient (ADC) and fractional anisotropy (FA) assessments obtained from the diffusion-prepared fast imaging with steady-state free precession (DP-FISP) acquisition resulted in good agreement with EPI and spin echo diffusion methods. The mean apparent diffusion coefficient was 2.0 × 10(-3) mm(2) /s, 1.90 × 10(-3) mm(2) /s, and 1.97 × 10(-3) mm(2) /s for DP-FISP, diffusion-weighted spin echo, and diffusion-weighted EPI, respectively. The mean fractional anisotropy was 0.073, 0.072, and 0.070 for diffusion-prepared fast imaging with steady-state free precession, diffusion-weighted spin echo, and diffusion-weighted EPI, respectively. Initial in vivo studies show reasonable ADC values in a normal mouse brain and polycystic rat kidneys.
authors.affiliation: Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Lan
authors.initials: L
authors.lastname: Lu
authors.forename: Bernadette
authors.initials: B
authors.lastname: Erokwu
authors.forename: Gregory
authors.initials: G
authors.lastname: Lee
authors.forename: Vikas
authors.initials: V
authors.lastname: Gulani
authors.forename: Mark A
authors.initials: MA
authors.lastname: Griswold
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Dell
authors.forename: Chris A
authors.initials: CA
authors.lastname: Flask
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D007690:Polycystic Kidney Diseases / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity