title: ABO-incompatible lung transplantation in an infant.
abstract: Waitlist mortality continues to be a limiting factor for all solid-organ transplant programs. Strategies that could improve this situation should be considered. We report the first ABO-incompatible lung transplantation in an infant. The recipient infant was ABO blood group A1 and the donor group B. The recipient was diagnosed with surfactant protein B deficiency, which is a fatal condition and lung transplantation is the only definitive therapy. At 32 days of age, a bilateral lung transplantation from a donation after cardiac death (DCD) donor was performed. Intraoperative plasma exchange was the only preparatory procedure performed. No further interventions were required as the recipient isohemagglutinins were negative before transplant and have remained negative to date. At 6 months posttransplant, the recipient is at home, thriving, with normal development. This outcome suggests that ABO-incompatible lung transplantation is feasible in infants, providing another option to offer life-saving lung transplantation in this age range.
authors.affiliation: Department of Pediatrics, Transplant Center, Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Grasemann
authors.forename: M
authors.initials: M
authors.lastname: de Perrot
authors.forename: G N
authors.initials: GN
authors.lastname: Bendiak
authors.forename: P
authors.initials: P
authors.lastname: Cox
authors.forename: G S
authors.initials: GS
authors.lastname: van Arsdell
authors.forename: S
authors.initials: S
authors.lastname: Keshavjee
authors.forename: M
authors.initials: M
authors.lastname: Solomon
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D000017:ABO Blood-Group System / Q000276:immunology; D001787:Blood Group Incompatibility; D016040:Lung Transplantation; D011649:Pulmonary Alveolar Proteinosis / Q000151:congenital / Q000628:therapy; D037701:Pulmonary Surfactant-Associated Protein B / Q000172:deficiency; D014019:Tissue Donors; D016896:Treatment Outcome; D017563:Lung Diseases, Interstitial
chemical_list: D000017:ABO Blood-Group System; D037701:Pulmonary Surfactant-Associated Protein B