title: Effects of 3-month Mediterranean-type diet on postprandial TAG and apolipoprotein B48 in the Medi-RIVAGE cohort.
abstract: OBJECTIVE
  To determine the postprandial lipaemia response before and after intervention with healthy diets in the Medi-RIVAGE cohort of subjects with moderate risk factors of CVD.
  
  
  METHODS
  One hundred and thirty-five adults (fifty-two men and eighty-three women) followed either a Mediterranean-type (MED) diet or a low-fat American Heart Association-type diet in a parallel design for 3 months. At entry and after 3 months, lipids, glucose and insulin were measured in the fasting samples; TAG and apolipoprotein B48 (ApoB48; a marker of intestinally derived chylomicrons) levels were measured in the fasting and postprandial samples after a standard test meal.
  
  
  RESULTS
  The MED diet only lowered (P < 0·028) fasting TAG and both diets reduced TAG and ApoB48 levels 5 h after the test meal. The overall 5 h postprandial ApoB48 response (area under curve (AUC)/incremental AUC) was lowered after both diets but this effect was more marked after the MED-diet intervention. Whatever the TAG level at entry, normo- and hyper TAG subjects showed a reduction in the postprandial ApoB48 levels after 3-month diets. BMI at entry did not impact the effect of diets given subjects with BMI < or >25 kg/m2 showed reduced postprandial ApoB48. Men and women displayed comparable postprandial changes after dietary challenges.
  
  
  CONCLUSIONS
  A MED diet appears efficient to improve postprandial lipaemia, a recently acknowledged CVD risk, in men and women at moderate cardiovascular risk.
authors.affiliation: INRA, UMR1260 and INSERM ERL1025 "Nutriments Lipidiques et Prévention des Maladies Métaboliques", Faculté de Médecine, IPHM-IFR 125, 27 Boulevard Jean Moulin, Marseille, 13385 Cedex 05, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Defoort
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Vincent-Baudry
authors.forename: Denis
authors.initials: D
authors.lastname: Lairon
mesh_terms: D000328:Adult; D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood*; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D015331:Cohort Studies; D018752:Diet, Fat-Restricted; D038441:Diet, Mediterranean; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011322:Primary Prevention; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D053283:Apolipoprotein B-48; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides