title: Synergistic bactericidal effects and mechanisms of low intensity ultrasound and antibiotics against bacteria: a review.
abstract: Low intensity ultrasonic therapy is always an important research area of ultrasonic medicine. This review concentrates on low intensity ultrasound enhancing bactericidal action of antibiotics against bacteria in vitro and in vivo, including planktonic bacteria, bacterial biofilms, Chlamydia, and bacteria in implants. These literatures show that low intensity ultrasound alone is not effective in killing bacteria, while the combination of low intensity ultrasound and antibiotics is promising. Low intensity ultrasound facilitating antibiotic treatment is still in its infancy, and still requires a great deal of research in order to develop the technology on medical treatment scale.
authors.affiliation: Biomedical Engineering Department, Zhejiang University, Hangzhou Zhejiang 310027, China. yuhao_zju@163.com
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Siping
authors.initials: S
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Cao
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects* / Q000528:radiation effects*; D019220:High-Energy Shock Waves; D011829:Radiation Dosage; D013010:Sonication / Q000295:instrumentation*; D013242:Sterilization / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents