title: Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.
abstract: Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.
authors.affiliation: Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany. joerg.ellinger@ukb.uni-bonn.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Ellinger
authors.forename: Philip
authors.initials: P
authors.lastname: Kahl
authors.forename: Johannes
authors.initials: J
authors.lastname: von der Gathen
authors.forename: Lukas C
authors.initials: LC
authors.lastname: Heukamp
authors.forename: Ines
authors.initials: I
authors.lastname: Gütgemann
authors.forename: Bernhard
authors.initials: B
authors.lastname: Walter
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Hofstädter
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Bastian
authors.forename: Alexander
authors.initials: A
authors.lastname: von Ruecker
authors.forename: Stefan C
authors.initials: SC
authors.lastname: Müller
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rogenhofer
mesh_terms: D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008745:Methylation; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
chemical_list: D006657:Histones