title: Tolerance and safety evaluation in a large cohort of healthy infants fed an innovative prebiotic formula: a randomized controlled trial.
abstract: BACKGROUND
  the addition of oligosaccharides to infant formula has been shown to mimic some of the beneficial effects of human milk. The aim of the study was to assess the tolerance and safety of a formula containing an innovative mixture of oligosaccharides in early infancy.
  
  
  RESULTS
  this study was performed as a multi-center, randomized, double-blind, placebo-controlled trial including healthy term infants. Infants were recruited before the age of 8 weeks, either having started with formula feeding or being fully breast-fed (breastfeeding group). Formula-fed infants were randomized to feeding with a regular formula containing a mixture of neutral oligosaccharides and pectin-derived acidic oligosaccharides (prebiotic formula group) or regular formula without oligosaccharides (control formula group). Growth, tolerance and adverse events were assessed at 8, 16, 24 and 52 weeks of age. The prebiotic and control groups showed similar mean weight, length and head circumference, skin fold thicknesses, arm circumference gains and stool frequency at each study point. As far as the anthropometric parameters are concerned, the prebiotic group and the control group did not attain the values shown by the breastfeeding group at any study point. The skin fold thicknesses assessed in the breastfeeding group at 8 weeks were strikingly larger than those in formula fed infants, whereas at 52 weeks were strikingly smaller. The stool consistency in the prebiotic group was softer than in the control group at 8, 16 and 24 weeks (p<0.001) and closer to that of the breastfeeding group. There was no difference in the incidence of adverse events between the two formula groups.
  
  
  CONCLUSIONS
  our findings demonstrate the tolerability and the long term safety of a formula containing an innovative mixture of oligosaccharides in a large cohort of healthy infants.
  
  
  BACKGROUND
  drks-neu.uniklinik-freiburg.de DRKS 00000201.
authors.affiliation: Department of Maternal and Pediatric Sciences, Fondazione IRCCS ''Ca'Granda'' Ospedale Maggiore Policlinico, University of Milan, Milano, Italy.
authors.forename: Pasqua
authors.initials: P
authors.lastname: Piemontese
authors.forename: Maria L
authors.initials: ML
authors.lastname: Giannì
authors.forename: Christian P
authors.initials: CP
authors.lastname: Braegger
authors.forename: Gaetano
authors.initials: G
authors.lastname: Chirico
authors.forename: Christoph
authors.initials: C
authors.lastname: Grüber
authors.forename: Josef
authors.initials: J
authors.lastname: Riedler
authors.forename: Sertac
authors.initials: S
authors.lastname: Arslanoglu
authors.forename: Margriet
authors.initials: M
authors.lastname: van Stuijvenberg
authors.forename: Günther
authors.initials: G
authors.lastname: Boehm
authors.forename: Jürgen
authors.initials: J
authors.lastname: Jelinek
authors.forename: Paola
authors.initials: P
authors.lastname: Roggero
mesh_terms: D001132:Arm / Q000033:anatomy & histology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002508:Cephalometry; D015331:Cohort Studies; D005243:Feces; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D041981:Gastrointestinal Tract / Q000502:physiology; D006262:Health; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008297:Male; D056692:Prebiotics / Q000009:adverse effects*; D012885:Skinfold Thickness
chemical_list: D056692:Prebiotics