title: Juvenile xanthogranulomatosis with bilateral and multifocal ocular lesions of the iris, cornealscleral limbus, and choroid.
abstract: A 14-month-old boy with juvenile xanthogranuloma skin lesions presented with increased intraocular pressure, hyphema, anterior uveitis, iris mass, and a subconjunctival limbal mass of the right eye. He subsequently developed a subretinal mass in the left eye. The anterior uveitis resolved after 2 periocular injections of triamcinolone in addition to the administration of topical prednisolone and oral prednisone and methotrexate. The subretinal mass in the left eye also resolved during the course of 1 year. He developed a cataract in the right eye and underwent lensectomy with anterior vitrectomy. This is the first published case in which methotrexate was used as an adjunctive treatment of juvenile xanthogranuloma in a child.
authors.affiliation: Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52246, USA. Susannah-longmuir@uiowa.edu
authors.forename: Susannah
authors.initials: S
authors.lastname: Longmuir
authors.forename: Alina
authors.initials: A
authors.lastname: Dumitrescu
authors.forename: Young
authors.initials: Y
authors.lastname: Kwon
authors.forename: H Culver
authors.initials: HC
authors.lastname: Boldt
authors.forename: Sandy
authors.initials: S
authors.lastname: Hong
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000627:therapeutic use; D000293:Adolescent; D002386:Cataract / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005128:Eye Diseases / Q000188:drug therapy* / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D016896:Treatment Outcome; D014972:Xanthogranuloma, Juvenile / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000277:Adjuvants, Pharmaceutic; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D008727:Methotrexate