title: [Pharmacokinetics of phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intravenous injection].
abstract: The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).
authors.forename: G A
authors.initials: GA
authors.lastname: Chernyshova
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: E A
authors.initials: EA
authors.lastname: Ianovskaia
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: A V
authors.initials: AV
authors.lastname: Kuchin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Chukicheva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D001892:Camphanes / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D003408:Cresols / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: C533990:4-methyl-2,6-diisobornylphenol; D000975:Antioxidants; D001892:Camphanes; D003408:Cresols