title: Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.
abstract: The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.
authors.affiliation: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Belser
authors.forename: Katrina
authors.initials: K
authors.lastname: Sleeman
authors.forename: Melissa B
authors.initials: MB
authors.lastname: Pearce
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Katz
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Gubareva
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Tumpey
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003231:Conjunctivitis / Q000188:drug therapy / Q000821:virology*; D005123:Eye / Q000187:drug effects / Q000821:virology; D006801:Humans; D057920:Influenza A Virus, H7N3 Subtype / Q000187:drug effects* / Q000502:physiology; D053126:Influenza A Virus, H7N7 Subtype / Q000187:drug effects* / Q000502:physiology; D007251:Influenza, Human / Q000821:virology; D056965:Injections, Intraocular; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000821:virology*; D053139:Oseltamivir / Q000494:pharmacology*; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D053139:Oseltamivir; D009439:Neuraminidase