title: Dehydroepiandrosterone sulphate: action and mechanism in the brain.
abstract: Dehydroepiandrosterone sulphate (DHEAS) is synthesised from dehydroepiandrosterone by the enzyme sulphotransferase. DHEAS is one of the most important neurosteroids in the brain. The concentration of DHEAS in the brain is sometimes higher than peripheral system. At the cellular level, DHEAS has been shown to modulate a variety of synaptic transmission, including cholinergic, GABAergic dopaminergic and glutamatergic synaptic transmission. In addition to the effect on the release of a number of neurotransmitters, DHEAS could also modulate the activity of postsynaptic receptors. DHEAS has been found to have multiple important effects on brain functions, such as memory enhancing, antidepressant and anxiolytic effects, and may have relationships with many brain diseases.
authors.affiliation: State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
authors.forename: P
authors.initials: P
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism*; D008568:Memory / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D019314:Dehydroepiandrosterone Sulfate