title: An introduction to the informatics of "next-generation" sequencing.
abstract: Next-generation sequencing (NGS) packs the sequencing throughput of a 2000's-era genome center into a single affordable machine. However, software developed for conventional sequencing technologies is often inadequate to deal with the nature of NGS technologies, which produce short, massively parallel reads. This unit surveys the software packages that are available for managing and analyzing NGS data.
authors.affiliation: Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
authors.forename: Lincoln D
authors.initials: LD
authors.lastname: Stein
mesh_terms: D019295:Computational Biology; D016678:Genome; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000295:instrumentation / Q000379:methods*; D012984:Software