title: [Experimental study of indium-111 labeled octreotide application for radionuclide diagnostics of tumors with high expression of somatostatin receptors].
abstract: We have studied the possibility of using octreoitid labeled by indium-111 for radionuclide diagnostics of neoplasms with high expression of somatostatin receptors. It has been established that, using experiments with cell cultures, it is possible to predict the application of 111In-labeled octreotid and determine time intervals for the best visualization of tumors. Indium-111-labeled octreotid accumulation in animals with transferred B16 tumor (pigment melanoma) shows evidence for the opportunity of using this substance as radiopharmaceutical medium for tumor diagnostics.
authors.forename: M G
authors.initials: MG
authors.lastname: Grinin
authors.forename: N L
authors.initials: NL
authors.lastname: Shimanovskiĭ
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D015282:Octreotide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D011485:Protein Binding; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017481:Receptors, Somatostatin / Q000096:biosynthesis*; D014018:Tissue Distribution
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D015282:Octreotide