title: Anti-inflammatory activity of Pistacia lentiscus essential oil: involvement of IL-6 and TNF-alpha.
abstract: The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-alpha and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.
authors.affiliation: Department of Life and Environment Sciences, Botany and Botanical Garden Division, University of Cagliari, Cagliari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Maxia
authors.forename: Cinzia
authors.initials: C
authors.lastname: Sanna
authors.forename: Maria Assunta
authors.initials: MA
authors.lastname: Frau
authors.forename: Alessandra
authors.initials: A
authors.lastname: Piras
authors.forename: Manvendra Singh
authors.initials: MS
authors.lastname: Karchuli
authors.forename: Veena
authors.initials: V
authors.lastname: Kasture
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D027927:Pistacia / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D009822:Oils, Volatile; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha