title: [Comparative experimental study of antioxidant efficiency in treatment of acute pancreatitis].
abstract: The aims of our experiments on animals were (i) to evaluate by direct oximery the efficiency of various antioxidant drugs in a complex treatment of acute pancreatitis and (ii) to determine the diagnostic value of the direct oximetry method for estimation of the efficiency of medical treatment. The article presents data obtained in a group 75 outbred Guinea with a model acute pancreatitis, which were treated with mexibel (group 1), emoxipin (group 2), end cytoflavin (group 3), with subsequent investigation of the pancreatic tissues by the direct oximetry method. The obtained results confirmed that the intraperitoneal injection of cytoflavin to animals stimulates tissue respiration, improves metabolism, promotes pancreas recovery, and also improves the prognosis and reduces the lethal outcome. The efficiency of cytoflavin within the complex therapy exceeds the effect of other antioxidants (mexibel and emoxipin) under otherwise equal conditions.
authors.forename: D A
authors.initials: DA
authors.lastname: Kliuĭko
authors.forename: V E
authors.initials: VE
authors.lastname: Korik
authors.forename: S A
authors.initials: SA
authors.lastname: Zhidkov
mesh_terms: D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007290:Inosine Diphosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D009536:Niacinamide / Q000008:administration & dosage / Q000627:therapeutic use*; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism; D010313:Partial Pressure; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D010847:Picolines; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; C070020:emoxypine succinate; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D010100:Oxygen; C009820:6-methyl-2-ethyl-3-hydroxypyridine