title: Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and  the  personality trait psychoticism?
abstract: BACKGROUND
  The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.
  
  
  METHODS
  We studied the Gly82Ser polymorphism (rs2070600, 244G>A) in 2 population-based cohorts of middle-aged participants assessed using the Karolinska Scales of Personality. In addition, we compared genotype frequencies between patients with schizophrenia and controls.
  
  
  RESULTS
  The population-based cohorts included 270 women and 247 men, and the case-control study involved 138 patients with schizophrenia and 258 controls. In the population-based cohorts, 82Ser carriers were found to have significantly higher scores for the psychoticism personality trait comprising the detachment and suspicion subscales. The case-control study revealed that the 82Ser allele was significantly more frequent among patients than controls.
  
  
  CONCLUSIONS
  This study was limited by the modest sample size and the use of a self-report measure to assess personality traits.
  
  
  CONCLUSIONS
  Our findings suggest that the proven relation between certain personality traits and schizophrenia can at least to some extent be explained on a genetic level. Also, the activated S100B-RAGE axis may be an underlying cause, not only a consequence, of the disease.
authors.affiliation: Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden. petra.suchankova@pharm.gu.se
authors.forename: Petra
authors.initials: P
authors.lastname: Suchankova
authors.forename: Jonas
authors.initials: J
authors.lastname: Klang
authors.forename: Carin
authors.initials: C
authors.lastname: Cavanna
authors.forename: Göran
authors.initials: G
authors.lastname: Holm
authors.forename: Staffan
authors.initials: S
authors.lastname: Nilsson
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Agneta
authors.initials: A
authors.lastname: Ekman
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000235:genetics; D010551:Personality / Q000235:genetics*; D010556:Personality Tests; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000523:psychology*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D009414:Nerve Growth Factors; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D004247:DNA