title: Successful outcome of two pregnancies in patients with adult-onset Still's disease treated with IL-1 receptor antagonist (anakinra).
abstract: Adult onset Still's disease (AOSD) is an uncommon, systemic, inflammatory disorder of unknown etiology, characterised by spiking fevers, skin rash, and arthritis. Treatment consists of glucocorticosteroids and immunosuppressive drugs. Over the last few years it has become increasingly evident that treatment with the IL-1 receptor antagonist (IL-1RA) anakinra is highly effective even in patients with intractable disease. So far, there are scant data available on the effects of anakinra in pregnancy. We report two patients with AOSD who successfully gave birth while treated with anakinra during pregnancy.
authors.affiliation: Department of Endocrinology, Heinrich-Heine-University, Duesseldorf, Germany. rebecca.fischer@med.uni-duesseldorf.de
authors.forename: Rebecca
authors.initials: R
authors.lastname: Fischer-Betz
authors.forename: Christoph
authors.initials: C
authors.lastname: Specker
authors.forename: Matthias
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D050498:Live Birth; D011247:Pregnancy; D011248:Pregnancy Complications; D012074:Remission Induction; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein