title: The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury.
abstract: Serious injuries of uterine which lead to scar formation will finally result in infertility or pregnancy complications. There are few effective methods to treat such damages because of the shortage of native tissues. Vascular endothelial growth factor (VEGF) is important for the formation of new vessels and re-epithelialization of endometrium. Here we produced a collagen-binding VEGF by fusing a collagen-binding domain to the N-terminal of native VEGF. After injection into a rat scarred uterus model (partial of rat uterine horn was excised and left for scar formation) the collagen targeting VEGF promoted remodeling of the scarred uterus including the regeneration of endometrium, muscular cells, and vascularization and improved pregnancy outcomes. Thus, collagen-binding VEGF may be a pragmatic solution for the treatment of severe uterine damages.
authors.affiliation: Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu Province 210008, China.
authors.forename: Nacheng
authors.initials: N
authors.lastname: Lin
authors.forename: Xin'an
authors.initials: X
authors.lastname: Li
authors.forename: Tianran
authors.initials: T
authors.lastname: Song
authors.forename: Jingmei
authors.initials: J
authors.lastname: Wang
authors.forename: Kui
authors.initials: K
authors.lastname: Meng
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Xianglin
authors.initials: X
authors.lastname: Hou
authors.forename: Jianwu
authors.initials: J
authors.lastname: Dai
authors.forename: Yali
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002921:Cicatrix / Q000473:pathology; D003094:Collagen / Q000737:chemistry*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009389:Neovascularization, Pathologic; D017434:Protein Structure, Tertiary; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D014599:Uterus / Q000166:cytology / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D042461:Vascular Endothelial Growth Factor A; D003094:Collagen