title: Use of an omega-3 fatty acid-based emulsion in the treatment of parenteral nutrition-induced cholestasis in patients with microvillous inclusion disease.
abstract: Microvillous inclusion disease is a congenital intestinal epithelial cell disorder leading to lifelong intestinal failure. In this report, we discuss the use of a fish oil-based lipid emulsion in the treatment of 3 patients with microvillous inclusion disease who developed parenteral nutrition-associated liver disease.
authors.affiliation: University of Texas Southwestern Medical School, Dallas, TX 75235, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Fuchs
authors.forename: Erica M
authors.initials: EM
authors.lastname: Fallon
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Gura
authors.forename: Mark
authors.initials: M
authors.lastname: Puder
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use; D001663:Bilirubin / Q000097:blood; D001942:Breast Feeding; D002097:C-Reactive Protein / Q000032:analysis; D002675:Child, Preschool; D002779:Cholestasis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D003968:Diarrhea, Infantile / Q000209:etiology / Q000628:therapy; D004573:Electrolytes / Q000627:therapeutic use; D004655:Emulsions / Q000009:adverse effects; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D005395:Fish Oils / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D002479:Inclusion Bodies; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000601:surgery; D007422:Intestines / Q000637:transplantation; D008107:Liver Diseases / Q000209:etiology / Q000628:therapy; D008286:Malabsorption Syndromes / Q000150:complications / Q000601:surgery / Q000628:therapy*; D008297:Male; D008871:Microvilli / Q000473:pathology; D009081:Mucolipidoses / Q000150:complications / Q000601:surgery / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects*; D057947:Parenteral Nutrition Solutions / Q000627:therapeutic use; D010743:Phospholipids / Q000009:adverse effects*; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000628:therapy*; D012996:Solutions / Q000627:therapeutic use; D013024:Soybean Oil / Q000009:adverse effects*; D014184:Transplantation, Homologous; D014280:Triglycerides
chemical_list: D000596:Amino Acids; D004573:Electrolytes; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D057947:Parenteral Nutrition Solutions; D010743:Phospholipids; D012996:Solutions; D014280:Triglycerides; C545824:amino-acid, glucose, and electrolyte solution; C568345:fish oil triglycerides; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil; D002097:C-Reactive Protein; D005947:Glucose; D001663:Bilirubin