title: Oral-paliperidone-induced tardive dyskinesia: a case report.
abstract: OBJECTIVE
  Tardive dyskinesia (TD) is generally considered the most severe extrapyramidal sequelae of antipsychotic treatments.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  We present a 20-year-old woman with previous treatment of risperidone 6-7 mg daily for approximately 4 years. She developed TD 2 years later after switching to paliperidone 9 mg daily. To the best of our knowledge, she is the first case report of having direct paliperidone-induced TD. Immediate treatments including paliperidone dose reduction to 6 mg daily, clonazepam 1.5 mg daily and trihexyphenidyl 2 mg daily were performed for 1 month, and her symptoms were relieved eventually after switching to clozapine 75 mg daily.
  
  
  CONCLUSIONS
  Although second-generation antipsychotics such as paliperidone are considered to have a lowered risk of developing TD, this case could bring awareness to clinicians of the possibility of TD with the use of any antipsychotics.
authors.affiliation: Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Han-Ting
authors.initials: HT
authors.lastname: Wei
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Lai
authors.forename: Mu-Hong
authors.initials: MH
authors.lastname: Chen
authors.forename: Ying-Sheue
authors.initials: YS
authors.lastname: Chen
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D000068882:Paliperidone Palmitate; D011743:Pyrimidines / Q000009:adverse effects*; D013624:Taiwan; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D000068882:Paliperidone Palmitate