title: Essential oil of Myrtus communis inhibits inflammation in rats by reducing serum IL-6 and TNF-alpha.
abstract: The topical antiinflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-alpha and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits antiinflammatory activity.
authors.affiliation: Department of Life and Environment Sciences, Botany and Botanical Garden Division, University of Cagliari, Cagliari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Maxia
authors.forename: Maria Assunta
authors.initials: MA
authors.lastname: Frau
authors.forename: Danilo
authors.initials: D
authors.lastname: Falconieri
authors.forename: Manvendra Singh
authors.initials: MS
authors.lastname: Karchuli
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kasture
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D031651:Myrtus / Q000378:metabolism*; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D009195:Peroxidase / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000235:genetics / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D009822:Oils, Volatile; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; D009195:Peroxidase