title: Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
abstract: Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
authors.affiliation: Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109-2700, USA.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Rabinak
authors.forename: Chandra Sekhar
authors.initials: CS
authors.lastname: Sripada
authors.forename: Mike
authors.initials: M
authors.lastname: Angstadt
authors.forename: Harriet
authors.initials: H
authors.lastname: de Wit
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects; D004311:Double-Blind Method; D013759:Dronabinol / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000502:physiology; D006213:Hallucinogens / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D010775:Photic Stimulation; D011930:Reaction Time / Q000187:drug effects; D055815:Young Adult
chemical_list: D006213:Hallucinogens; D013759:Dronabinol