title: Napsin A expression in lung and kidney neoplasia: a review and update.
abstract: Napsin A is an aspartic protease present in the epithelial cells of the lung and kidney. Recent studies have shown that, in lung tumors, napsin A expression is restricted to lung adenocarcinomas, whereas among renal tumors, it is frequently expressed in renal cell carcinomas, especially the papillary and clear cell subtypes. Owing to its restricted expression, napsin A is a useful marker that can assist in the diagnosis of both lung adenocarcinomas and renal cell carcinomas.
authors.affiliation: University of Texas, M.D. Anderson Cancer Center, Houston, 77030, USA. nordonez@mdanderson.org
authors.forename: Nelson G
authors.initials: NG
authors.lastname: Ordóñez
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016282:Aspartic Acid Endopeptidases; C498549:NAPSA protein, human