title: Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91).
abstract: Two anabaenopeptin-type peptides, lyngbyaureidamides A and B, together with two previously reported peptides lyngbyazothrins C and D, were isolated from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91). Their structures were determined by spectroscopic and chemical methods. Lyngbyazothrins C and D were also able to inhibit the 20S proteasome with IC(50) values of 7.1 μM and 19.2 μM, respectively, while lyngbyaureidamides A and B were not active at 50 μM.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Lantvit
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: Jimmy
authors.initials: J
authors.lastname: Orjala
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D061988:Proteasome Inhibitors
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; D061988:Proteasome Inhibitors; C572841:lyngbyaureidamide A; C572842:lyngbyaureidamide B; C572843:lyngbyazothrin C; C572844:lyngbyazothrin D