title: Cdh1 is a HECT of an activator.
abstract: Cdh1 is a well-established activator of APC/C, a RING-type ubiquitin ligase. In this issue of Molecular Cell, Wan et al. (2011) report an APC/C-independent role of Cdh1 during development as an activator for Smurf1, a HECT-type ubiquitin ligase.
authors.affiliation: Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Luying
authors.initials: L
authors.lastname: Jia
authors.forename: Hongtao
authors.initials: H
authors.lastname: Yu