title: Inflammation profile of four early onset Crohn patients.
abstract: Crohn disease (CD) is a multifactorial disorder affecting mainly young adults. Sometimes, however, it can present in the first year of life (Early onset Crohn disease (EOCD)) showing an unpredictable course and can often be more severe than at older ages. Some cases have been associated to an underlying primary immunodeficiency such as IL10R deficiency. We studied the functional response to IL-10 and the genotype of IL-10 receptor in four patients with early onset crohn-like colitis. We found an IL10R variant, which may be associated with a decreased response to the cytokine in one patient. Further studies to determine its pathogenic effect should be performed. In addition IL-10 mediated inhibition of LPS-induced TNFα expression was measured in patient's monocytes.
authors.affiliation: Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Marcuzzi
authors.forename: Martina
authors.initials: M
authors.lastname: Girardelli
authors.forename: Anna Monica
authors.initials: AM
authors.lastname: Bianco
authors.forename: Stefano
authors.initials: S
authors.lastname: Martelossi
authors.forename: Andrea
authors.initials: A
authors.lastname: Magnolato
authors.forename: Alberto
authors.initials: A
authors.lastname: Tommasini
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D003424:Crohn Disease / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009000:Monocytes / Q000378:metabolism; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D011110:Polymorphism, Genetic; D053701:Receptors, Interleukin-10 / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D053701:Receptors, Interleukin-10; D014409:Tumor Necrosis Factor-alpha