title: In-silico human genomics with GeneCards.
abstract: Since 1998, the bioinformatics, systems biology, genomics and medical communities have enjoyed a synergistic relationship with the GeneCards database of human genes (http://www.genecards.org). This human gene compendium was created to help to introduce order into the increasing chaos of information flow. As a consequence of viewing details and deep links related to specific genes, users have often requested enhanced capabilities, such that, over time, GeneCards has blossomed into a suite of tools (including GeneDecks, GeneALaCart, GeneLoc, GeneNote and GeneAnnot) for a variety of analyses of both single human genes and sets thereof. In this paper, we focus on inhouse and external research activities which have been enabled, enhanced, complemented and, in some cases, motivated by GeneCards. In turn, such interactions have often inspired and propelled improvements in GeneCards. We describe here the evolution and architecture of this project, including examples of synergistic applications in diverse areas such as synthetic lethality in cancer, the annotation of genetic variations in disease, omics integration in a systems biology approach to kidney disease, and bioinformatics tools.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. gil.stelzer@weizmann.ac.il
authors.forename: Gil
authors.initials: G
authors.lastname: Stelzer
authors.forename: Irina
authors.initials: I
authors.lastname: Dalah
authors.forename: Tsippi Iny
authors.initials: TI
authors.lastname: Stein
authors.forename: Yigeal
authors.initials: Y
authors.lastname: Satanower
authors.forename: Naomi
authors.initials: N
authors.lastname: Rosen
authors.forename: Noam
authors.initials: N
authors.lastname: Nativ
authors.forename: Danit
authors.initials: D
authors.lastname: Oz-Levi
authors.forename: Tsviya
authors.initials: T
authors.lastname: Olender
authors.forename: Frida
authors.initials: F
authors.lastname: Belinky
authors.forename: Iris
authors.initials: I
authors.lastname: Bahir
authors.forename: Hagit
authors.initials: H
authors.lastname: Krug
authors.forename: Paul
authors.initials: P
authors.lastname: Perco
authors.forename: Bernd
authors.initials: B
authors.lastname: Mayer
authors.forename: Eugene
authors.initials: E
authors.lastname: Kolker
authors.forename: Marilyn
authors.initials: M
authors.lastname: Safran
authors.forename: Doron
authors.initials: D
authors.lastname: Lancet
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D005796:Genes / Q000235:genetics*; D015894:Genome, Human; D023281:Genomics; D006801:Humans