title: PEG-SO(3)H catalyzed synthesis and cytotoxicity of α-aminophosphonates.
abstract: One pot three-component PEG-SO(3)H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik-Field's reaction. These new structurally diversified set of α-aminophosphonates (4a-j) were evaluated for their anti-tumor activity on human chronic myeloid leukemia cells (K 562), human colon carcinoma cells (Colo 205) along with non-cancerous human embryonic kidney cells (HEK 293). They showed moderate activity on both cancerous cells and non-cancerous cells.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India.
authors.forename: C Bhupendra
authors.initials: CB
authors.lastname: Reddy
authors.forename: K Suresh
authors.initials: KS
authors.lastname: Kumar
authors.forename: M Anil
authors.initials: MA
authors.lastname: Kumar
authors.forename: M Veera
authors.initials: MV
authors.lastname: Narayana Reddy
authors.forename: B Satheesh
authors.initials: BS
authors.lastname: Krishna
authors.forename: M
authors.initials: M
authors.lastname: Naveen
authors.forename: M K
authors.initials: MK
authors.lastname: Arunasree
authors.forename: C Suresh
authors.initials: CS
authors.lastname: Reddy
authors.forename: C Naga
authors.initials: CN
authors.lastname: Raju
authors.forename: C Devendranath
authors.initials: CD
authors.lastname: Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; D013451:Sulfonic Acids; D011092:Polyethylene Glycols