title: Temporal dissociation between myeloperoxidase (MPO)-modified LDL and MPO elevations during chronic sleep restriction and recovery in healthy young men.
abstract: OBJECTIVE
  Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers.
  
  
  RESULTS
  Nine healthy male non-smokers, aged 22-29 years, were admitted to the Sleep Laboratory for 11 days and nights under continuous electroencephalogram polysomnography. The study consisted of three baseline nights of 8 hours sleep (from 11 pm to 7 am), five sleep-restricted nights, during which sleep was allowed only between 1 am and 6 am, and three recovery nights of 8 hours sleep (11 pm to 7 am). Myeloperoxidase-modified low-density lipoprotein levels increased during the sleep-restricted period indicating an oxidative stress. A significant increase in the quantity of slow-wave sleep was measured during the first recovery night. After this first recovery night, insulin-like growth factor-1 levels increased and myeloperoxidase concentration peaked.
  
  
  CONCLUSIONS
  We observed for the first time that sleep restriction and the recovery process are associated with differential changes in blood biomarkers of cardiovascular disease.
authors.affiliation: Laboratory of Experimental Medicine, Centre Hospitalo-Universitaire de Charleroi, André Vésale Hospital, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
authors.forename: Karim Zouaoui
authors.initials: KZ
authors.lastname: Boudjeltia
authors.forename: Brice
authors.initials: B
authors.lastname: Faraut
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Esposito
authors.forename: Patricia
authors.initials: P
authors.lastname: Stenuit
authors.forename: Michal
authors.initials: M
authors.lastname: Dyzma
authors.forename: Pierre Van
authors.initials: PV
authors.lastname: Antwerpen
authors.forename: Dany
authors.initials: D
authors.lastname: Brohée
authors.forename: Luc
authors.initials: L
authors.lastname: Vanhamme
authors.forename: Nicole
authors.initials: N
authors.lastname: Moguilevsky
authors.forename: Michel
authors.initials: M
authors.lastname: Vanhaeverbeek
authors.forename: Myriam
authors.initials: M
authors.lastname: Kerkhofs
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006262:Health; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016209:Interleukin-8 / Q000097:blood; D007962:Leukocytes / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D009195:Peroxidase / Q000097:blood*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000097:blood* / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D016209:Interleukin-8; D008077:Lipoproteins, LDL; D007334:Insulin-Like Growth Factor I; D005340:Fibrinogen; D002097:C-Reactive Protein; D009195:Peroxidase