title: Lack of association between hOGG1 Ser326Cys polymorphism and the risk of bladder cancer: a meta-analysis.
abstract: OBJECTIVE
  In some but not all studies, hOGG1 Ser326Cys polymorphism has been reported to contribute to the risk of bladder cancer. To determine whether there is a significant association of hOGG1 Ser326Cys polymorphism with the susceptibility for bladder cancer, we performed a comprehensive meta-analysis.
  
  
  METHODS
  The electronic PubMed, Medline and Springer databases were searched for publications on the association between hOGG1 Ser326Cys polymorphism and bladder cancer through to May 20, 2011. Seven case-control studies were identified, including 2,474 cases and 2,408 controls. From these identified publications, crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association using fixed- or random-effects models. Two investigators each extracted data and conducted the analysis independently.
  
  
  RESULTS
  Overall, no significant associations were found between hOGG1 Ser326Cys polymorphism and bladder cancer in codominant models (GG vs. CC: OR 1.11, 95% CI 0.74-1.66, p = 0.63; GC vs. CC: OR 1.07, 95% CI 0.80-1.41, p = 0.65). Similarly, no significant associations with bladder cancer were observed in the recessive model (GG vs. GC+CC: OR 1.05, 95% CI 0.65-1.70, p = 0.85), dominant model (GG+GC vs. CC: OR 1.07, 95% CI 0.87-1.32, p = 0.53) and allele model (G vs. C: OR 1.06, 95% CI 0.90-1.26, p = 0.49). In the stratified analyses by ethnicity, control sources, pathology, Hardy-Weinberg equilibrium, significant associations were still not observed.
  
  
  CONCLUSIONS
  The overall current literature on hOGG1 Ser326Cys polymorphism and the risk of bladder cancer suggests no statistically significant association between the two. Additional primary studies may be necessary to provide evidence of any significant association between this specific polymorphism and bladder cancer.
authors.affiliation: Department of Urology, Qilu Hospital, Shandong University, Jinan City, PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Hainan
authors.initials: H
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Yan
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Juchao
authors.initials: J
authors.lastname: Ren
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Xu
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D045647:DNA Glycosylases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human