title: Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat.
abstract: OBJECTIVE
  To assess the renoprotective activity of the water extract of Annona squamosa in 5/6 nephrectomized animals.
  
  
  METHODS
  For evaluating the renoprotective effects of Annona squamosa, 5/6 nephrectomized rats were used as a model for renal failure. The effects of hot-water extract of leaves of Annona squamosa L. (A. squamosa) at a dose 300 mg/kg bw on biochemical and urinary parameters like plasma urea, plasma creatinine, and urine creatinine were analyzed. For elucidating its effect on oxidative stress, renal superoxide dismutase (SOD) levels were measured.
  
  
  RESULTS
  Nephrectomized rats (5/6) showed a significant rise in plasma urea and creatinine levels with a stable fall in urine creatinine. Treatment with A. squamosa extract (300 mg/kg bw) lead to a significant fall in the plasma urea and creatinine values with partial restoration to normal values along with a significant rise in the activity of SOD.
  
  
  CONCLUSIONS
  Thus, therapeutic strategies against oxidative stress could be effective in renal diseases. This study provides an indication to investigate further the efficacy of A. squamosa as a novel agent for alleviating renal failure.
authors.affiliation: Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat, India.
authors.forename: Aaishwarya B
authors.initials: AB
authors.lastname: Deshmukh
authors.forename: Jayvadan K
authors.initials: JK
authors.lastname: Patel