title: Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery.
abstract: The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical. One hundred twenty-two patients completed the study. The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect. The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery.
authors.affiliation: Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico.
authors.forename: Héctor A
authors.initials: HA
authors.lastname: Ponce-Monter
authors.forename: Mario I
authors.initials: MI
authors.lastname: Ortiz
authors.forename: Alexis F
authors.initials: AF
authors.lastname: Garza-Hernández
authors.forename: Raúl
authors.initials: R
authors.lastname: Monroy-Maya
authors.forename: Marisela
authors.initials: M
authors.lastname: Soto-Ríos
authors.forename: Lourdes
authors.initials: L
authors.lastname: Carrillo-Alarcón
authors.forename: Gerardo
authors.initials: G
authors.lastname: Reyes-García
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernández-Martínez