title: Screening of Ficus religiosa leaves fractions for analgesic and anti-inflammatory activities.
abstract: OBJECTIVE
  To evaluate the different fractions of dried leaves of Ficus religiosa Linn for analgesic and anti-inflammatory activity using different models of pain and inflammation
  
  
  METHODS
  The analgesic activity of F. religiosa carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. Five different fractions (FRI, FRII, FRIII, FRIV and FRV) of F. religiosa at the dose level of 20 and 40 mg/kg, p.o were tested.
  
  
  RESULTS
  The fraction FRI (40 mg/kg, p.o.) and FRIII (40 mg/kg, p.o) were found to be more effective (P<0.01) in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation, and acetic acid induced writhing compared to the other fractions. FRI (20 mg/kg, p.o.) and FRIII (20 mg/kg, p.o.) were also found to be more effective in increasing latency period in tail flick method.
  
  
  CONCLUSIONS
  Out of five different fractions of F. religiosa leaves tested, FRI and FRIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.
authors.affiliation: Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik.
authors.forename: Vishal
authors.initials: V
authors.lastname: Gulecha
authors.forename: T
authors.initials: T
authors.lastname: Sivakumar
authors.forename: Aman
authors.initials: A
authors.lastname: Upaganlawar
authors.forename: Manoj
authors.initials: M
authors.lastname: Mahajan
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Upasani