title: Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A-C: Fibronectin Expression Regulators from Aspergillus novofumigatus.
abstract: Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Sato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wachi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Nagase
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawai