title: Secondary erythromelalgia successfully treated with intravenous immunoglobulin.
abstract: Erythromelalgia is a rare condition characterized by episodic painful erythema and warmth often affecting, but not limited to, the distal extremities. This condition is notoriously difficult to treat. We report a young female patient with seronegative polyarthritis who presented with a 6-year history of recurrent bouts of painful erythema and swelling often triggered by minor trauma. An extensive evaluation was unremarkable. Several medical therapies provided limited and inconsistent relief of her symptoms over many years. Treatment with intravenous immunoglobulin significantly decreased the frequency and severity of her symptoms.
authors.affiliation: Department of Pediatrics, Division of Child and Adolescent Neurology, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
authors.forename: Shadé
authors.initials: S
authors.lastname: Moody
authors.forename: Susan
authors.initials: S
authors.lastname: Pacheco
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Butler
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Koenig
mesh_terms: D000293:Adolescent; D001168:Arthritis / Q000150:complications; D004916:Erythromelalgia / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007275:Injections, Intravenous / Q000379:methods; D062556:NAV1.7 Voltage-Gated Sodium Channel / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D062556:NAV1.7 Voltage-Gated Sodium Channel; C486866:SCN9A protein, human