title: Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine.
abstract: OBJECTIVE
  Although migraine has been related with an increased risk for ischemic stroke and cardiovascular events, there is insufficient data for role of pro-brain natriuretic peptide (pro-BNP) in migraine. In present case-control study, serum levels of pro-inflammatory (TNF-alpha, IL-1beta and IL-6) and anti-inflammatory cytokines (IL-2, and IL-10) of migraine patients were investigated to determine the role of cytokines and pro-BNP in migraine.
  
  
  METHODS
  Sixty-four consecutive newly diagnosed migraine patients and 34 healthy controls were enrolled. Serum TNF-alpha, IL-1beta, IL-2, IL-6, IL-10 and pro-BNP levels were measured by using a chemiluminescence assay.
  
  
  RESULTS
  Migraine patients had significantly higher concentrations of IL-1beta and IL-6 compared with the healthy controls (for IL-1beta; 5.73 +/- 1.44 vs. 4.90 +/- 1.40 pg/mL, respectively, p = 0.006; for IL-6; 3.1 +/- 1.44 vs. 2.40 +/- 0.22 pg/mL, respectively, p = 0.007). The mean IL-10 levels were found to be significantly lower in migraine patients (3.38 +/- 2.93 pg/mL) than controls (6.76 +/- 1.48 pg/mL) (p = 0.007). There were no differences in TNF-alpha (27.2 +/- 48.1 vs. 15.4 +/- 0.7) and IL-2 (1017 +/- 661 vs. 1153 +/- 228) levels between patients with migraine and healthy controls. Migraine patients had higher concentrations of pro-BNP compared with healthy controls (27.0 +/- 28.0 versus 13.2 +/- 8.6, p = 0.006).
  
  
  CONCLUSIONS
  Migraine patients have higher serum IL-1beta and IL-6 levels, and lower IL-10 levels than healthy subjects. These findings support that cytokines may be related to neurogenic inflammation in the pathogenesis of migraine. Also, increased pro-BNP may indicate to preclinical cardiac involvement in patients with migraine.
authors.affiliation: Department of Neurology, School of Medicine, Dicle University, Diyarbakir, Turkey. ertuzar@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Uzar
authors.forename: O
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Y
authors.initials: Y
authors.lastname: Yucel
authors.forename: M
authors.initials: M
authors.lastname: Ugur Cevik
authors.forename: A
authors.initials: A
authors.lastname: Acar
authors.forename: I
authors.initials: I
authors.lastname: Guzel
authors.forename: Y
authors.initials: Y
authors.lastname: Islamoglu
authors.forename: L
authors.initials: L
authors.lastname: Colpan
authors.forename: N
authors.initials: N
authors.lastname: Tasdemir
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000209:etiology*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain