title: [The influence of C57B1/6J mice immunization by oxidized low-density lipoprotein on the intensity of atherosclerotic changes].
abstract: ApoE knockout C57B1/6J mice fed Western type diet were immunized by MDA-modified human LDL. After 8 weeks in 50% immunized mice the atherosclerotic lesions in aorta was absent whereas both in control group and in 50% immunized mice the region of atherosclerotic lesions was in average 6,6%. A positive correlation between area of lesions and level of antilipoprotein antibodies IgG2b was founded.
mesh_terms: D000818:Animals; D001011:Aorta / Q000276:immunology* / Q000473:pathology; D001018:Aortic Diseases / Q000097:blood / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D050197:Atherosclerosis / Q000097:blood / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000235:genetics / Q000276:immunology / Q000633:toxicity*; D051379:Mice; D018345:Mice, Knockout
chemical_list: D001057:Apolipoproteins E; D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein