title: Rhea--a manually curated resource of biochemical reactions.
abstract: Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive resource of expert-curated biochemical reactions. Rhea provides a non-redundant set of chemical transformations for use in a broad spectrum of applications, including metabolic network reconstruction and pathway inference. Rhea includes enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list), transport reactions and spontaneously occurring reactions. Rhea reactions are described using chemical species from the Chemical Entities of Biological Interest ontology (ChEBI) and are stoichiometrically balanced for mass and charge. They are extensively manually curated with links to source literature and other public resources on metabolism including enzyme and pathway databases. This cross-referencing facilitates the mapping and reconciliation of common reactions and compounds between distinct resources, which is a common first step in the reconstruction of genome scale metabolic networks and models.
authors.affiliation: Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK. rafael.alcantara@ebi.ac.uk
authors.forename: Rafael
authors.initials: R
authors.lastname: Alcántara
authors.forename: Kristian B
authors.initials: KB
authors.lastname: Axelsen
authors.forename: Anne
authors.initials: A
authors.lastname: Morgat
authors.forename: Eugeni
authors.initials: E
authors.lastname: Belda
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Coudert
authors.forename: Alan
authors.initials: A
authors.lastname: Bridge
authors.forename: Hong
authors.initials: H
authors.lastname: Cao
authors.forename: Paula
authors.initials: P
authors.lastname: de Matos
authors.forename: Marcus
authors.initials: M
authors.lastname: Ennis
authors.forename: Steve
authors.initials: S
authors.lastname: Turner
authors.forename: Gareth
authors.initials: G
authors.lastname: Owen
authors.forename: Lydie
authors.initials: L
authors.lastname: Bougueleret
authors.forename: Ioannis
authors.initials: I
authors.lastname: Xenarios
authors.forename: Christoph
authors.initials: C
authors.lastname: Steinbeck
mesh_terms: D001669:Biochemical Phenomena; D016208:Databases, Factual; D004798:Enzymes / Q000378:metabolism; D020407:Internet; D053858:Metabolic Networks and Pathways; D012984:Software
chemical_list: D004798:Enzymes