title: Modulation of TCRβ surface expression during TCR revision.
abstract: TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The downmodulation of surface TCR expression initiates TCR revision, and serves as a likely trigger for the induction of the recombinase machinery. We show here in a Vβ5 transgenic mouse model system that downregulation of the self-reactive transgene-encoded TCR is not maintained by transgene loss or diminished transcription or translation. The downregulation of surface TCR expression likely occurs in two stages, only one of which requires tolerogen expression.
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA, USA.
authors.forename: Kalynn B
authors.initials: KB
authors.lastname: Simmons
authors.forename: Maramawit
authors.initials: M
authors.lastname: Wubeshet
authors.forename: Kristina T
authors.initials: KT
authors.lastname: Ames
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: McMahan
authors.forename: J Scott
authors.initials: JS
authors.lastname: Hale
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Fink
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D007108:Immune Tolerance / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D019076:Transgenes / Q000235:genetics
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta