title: Fumonisin B1 and risk of hepatocellular carcinoma in two Chinese cohorts.
abstract: Fumonisin B1 (FB1), a mycotoxin that contaminates corn in certain climates, has been demonstrated to cause hepatocellular cancer (HCC) in animal models. Whether a relationship between FB1 and HCC exists in humans is not known. To examine the hypothesis, we conducted case-control studies nested within two large cohorts in China; the Haimen City Cohort and the General Population Study of the Nutritional Intervention Trials cohort in Linxian. In the Haimen City Cohort, nail FB1 levels were determined in 271 HCC cases and 280 controls. In the General Population Nutritional Intervention Trial, nail FB1 levels were determined in 72 HCC cases and 147 controls. In each population, odds ratios and 95% confidence intervals (95%CI) from logistic regression models estimated the association between measurable FB1 and HCC, adjusting for hepatitis B virus infection and other factors. A meta-analysis that included both populations was also conducted. The analysis revealed no statistically significant association between FB1 and HCC in either Haimen City (OR=1.10, 95%CI=0.64-1.89) or in Linxian (OR=1.47, 95%CI=0.70-3.07). Similarly, the pooled meta-analysis showed no statistically significant association between FB1 exposure and HCC (OR=1.22, 95%CI=0.79-1.89). These findings, although somewhat preliminary, do not support an associated between FB1 and HCC.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852-7234, USA. christina.persson@nih.gov
authors.forename: E Christina
authors.initials: EC
authors.lastname: Persson
authors.forename: Vikash
authors.initials: V
authors.lastname: Sewram
authors.forename: Alison A
authors.initials: AA
authors.lastname: Evans
authors.forename: W Thomas
authors.initials: WT
authors.lastname: London
authors.forename: Yvette
authors.initials: Y
authors.lastname: Volkwyn
authors.forename: Yen-Ju
authors.initials: YJ
authors.lastname: Shen
authors.forename: Jacobus A
authors.initials: JA
authors.lastname: Van Zyl
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Wenyao
authors.initials: W
authors.lastname: Lin
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Shephard
authors.forename: Philip R
authors.initials: PR
authors.lastname: Taylor
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Fan
authors.forename: Sanford M
authors.initials: SM
authors.lastname: Dawsey
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Katherine A
authors.initials: KA
authors.lastname: McGlynn
authors.forename: Christian C
authors.initials: CC
authors.lastname: Abnet
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D002681:China; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D037341:Fumonisins / Q000633:toxicity*; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D012307:Risk Factors; D053719:Tandem Mass Spectrometry
chemical_list: D037341:Fumonisins; C056933:fumonisin B1