title: Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives.
abstract: Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid esters, 1-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16-49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16, 17, 23, 24, 31, 32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, al. Gen. J. Hallera, Gdańsk, Poland. jaroslaw@gumed.edu.pl
authors.forename: Jarosław
authors.initials: J
authors.lastname: Sławiński
authors.forename: Beata
authors.initials: B
authors.lastname: Żołnowska
authors.forename: Danuta
authors.initials: D
authors.lastname: Pirska
authors.forename: Anna
authors.initials: A
authors.lastname: Kędzia
authors.forename: Ewa
authors.initials: E
authors.lastname: Kwapisz
mesh_terms: D000627:Aminophenols / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D000627:Aminophenols; D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D013449:Sulfonamides; C502762:4-chloro-2-mercaptobenzenesulfonamide; D000096926:Benzenesulfonamides; C005464:2-aminothiophenol; C027667:2-aminophenol