title: Impact of functional satellite groups on the antimicrobial activity and hemocompatibility of telechelic poly(2-methyloxazoline)s.
abstract: Polyoxazolines with a biocidal quarternary ammonium end-group are potent biocides. Interestingly, the antimicrobial activity of the whole macromolecule is controlled by the nature of the group at the distal end. These nonreactive groups are usually introduced via the initiator. Here we present a study with a series of polymethyloxazolines with varying satellite groups introduced upon termination of the polymerization reaction. This allowed us to introduce a series of functional satellites, including hydroxy, primary amino, and double-bond-containing groups. The resulting telechelic polyoxazolines were explored regarding their antimicrobial activity and toxicity. It was found that the functional satellite groups greatly controlled the minimal inhibitory concentrations against the bacteria Staphylococcus aureus and Escherichia coli in a range of 10 to 2500 ppm. Surprisingly, the satellite groups also controlled the hemotoxicity but in a different way than the antimicrobial efficiency.
authors.affiliation: Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
authors.forename: Christoph P
authors.initials: CP
authors.lastname: Fik
authors.forename: Christian
authors.initials: C
authors.lastname: Krumm
authors.forename: Christina
authors.initials: C
authors.lastname: Muennig
authors.forename: Theresa I
authors.initials: TI
authors.lastname: Baur
authors.forename: Ulrich
authors.initials: U
authors.lastname: Salz
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bock
authors.forename: Joerg C
authors.initials: JC
authors.lastname: Tiller
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes; D004926:Escherichia coli / Q000254:growth & development*; D006461:Hemolysis / Q000187:drug effects*; D011244:Pregnadienediols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*; D013552:Swine
chemical_list: D000890:Anti-Infective Agents; D011244:Pregnadienediols