title: Effects of the intermittent pneumatic circulator on blood pressure during hemodialysis.
abstract: Hypotension is frequently reported during hemodialysis. This study aimed to examine the effect of the intermittent pneumatic circulator on blood pressure during hemodialysis. Sixteen subjects with chronic hemodialysis were recruited. Each subject randomly received two test conditions on separate days, hemodialysis with and without the circulator. The circulator was applied to the subject on lower extremities during 0.5-1 hr, 1.5-2 hr, 2.5-3 hr, and 3.5-4 hr of hemodialysis. Systolic and diastolic blood pressures (SBP and DBP) and heart rate (HR) were analyzed at pre-dialysis, 1 hr, 2 hr, and 3 hr of hemodialysis. Stroke volume (SV) and cardiac output (CO) were evaluated between 2.5 and 3.0 hr of hemodialysis. Blood chemicals (sodium, calcium, potassium, and phosphorous) and Kt/V before and after each hemodialysis session were analyzed. The number of episodes of hypotension was also recorded. The circulator intervention significantly improved SBP and DBP across all time points (P = 0.002 for SBP; P = 0.002 for DBP). The frequency of hypotension was significantly decreased (P = 0.028). SV and CO were significantly improved with the circulator intervention (P = 0.017 for SV; P = 0.026 for CO) and no statistical significances were found on blood chemicals or Kt/V analyses. The results suggested that the circulator intervention helps stabilize blood pressure and appears to be a practical treatment. Future studies are suggested to develop new circulator innovations with sensor feedback systems to enhance safety and maximize treatment efficiency.
authors.affiliation: Department of Internal Medicine, Pao-Chien Hospital, Ping-Tung City, Taiwan. tc003022@ms34.hinet.net
authors.forename: Tzu-Chao
authors.initials: TC
authors.lastname: Hsu
authors.forename: Ya-Ju
authors.initials: YJ
authors.lastname: Chang
authors.forename: Yu-Yao
authors.initials: YY
authors.lastname: Huang
authors.forename: Miao-Ju
authors.initials: MJ
authors.lastname: Hsu
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D004581:Electronics / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*