title: Importance of (99)mTc-sestaMIBI thyroid scan in a case of amiodarone-induced thyrotoxicosis.
abstract: Amiodarone (AM)-induced thyrotoxicosis (AIT) is a condition with uncertainties from the diagnostic and therapeutic standpoints. A 54-year old male was referred to the hospital due to thyrotoxicosis. He had history of atrial fibrillation medicated with AM. No history of pre-existing thyroid disease was present, thyroid palpation revealed no goiter, and there were no signs of Graves' ophthalmopathy. Thyroid autoantibodies and thyroid-stimulating hormone receptor antibodies (TRABs) were negative. Thyroid and Doppler ultrasounds were normal. 99mTc-sestaMIBI thyroid scan (STS) showed uptake with rapid washout. AM therapy was discontinued, and combined therapy was started. After a long course of glucocorticoid and thionamides, the patient became euthyroid. It is necessary to distinguish between the types of AIT to decide whether or not continue AM treatment; after that, the appropriate therapy should be selected. STS was very important in the diagnosis of the type of AIT.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar S. João, Porto, Portugal.
authors.forename: Selma B
authors.initials: SB
authors.lastname: Souto
authors.forename: Helder
authors.initials: H
authors.lastname: Fernandes
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Matos
authors.forename: Daniel Carvalho
authors.initials: DC
authors.lastname: Braga
authors.forename: Jorge
authors.initials: J
authors.lastname: Pereira
authors.forename: Davide
authors.initials: D
authors.lastname: Carvalho
mesh_terms: D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D000638:Amiodarone