title: Microfluidic systems for biosensing.
abstract: In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summarize the recent advancements in two major types of micro fluidic systems, continuous and discrete MFS, as well as their biomedical applications. The state-of-the-art of active and passive mechanisms of fluid manipulation for mixing, separation, purification and concentration will also be elaborated. Future trends of using MFS in detection at molecular or cellular level, especially in stem cell therapy, tissue engineering and regenerative medicine, are also prospected.
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, UK. I.K.Liu@warwick.ac.uk
authors.forename: Kuo-Kang
authors.initials: KK
authors.lastname: Liu
authors.forename: Ren-Guei
authors.initials: RG
authors.lastname: Wu
authors.forename: Yun-Ju
authors.initials: YJ
authors.lastname: Chuang
authors.forename: Hwa Seng
authors.initials: HS
authors.lastname: Khoo
authors.forename: Shih-Hao
authors.initials: SH
authors.lastname: Huang
authors.forename: Fan-Gang
authors.initials: FG
authors.lastname: Tseng
mesh_terms: D015374:Biosensing Techniques; D016503:Drug Delivery Systems; D057230:Limit of Detection; D044085:Microfluidics / Q000295:instrumentation*; D013234:Stem Cells; D023822:Tissue Engineering