title: Cardiovascular disease and therapeutic drug-related cardiovascular consequences in HIV-infected patients.
abstract: The incidence of cardiovascular disease is greatly increased in the HIV-infected population compared with people of the same age without HIV. Cardiovascular manifestations of HIV/AIDS include, but are not limited to, accelerated atherosclerosis, pulmonary arterial hypertension, vasculitis, myocarditis, cardiomyopathy, pericardial diseases, malignancy (myocardial Kaposi sarcoma and B-cell immunoblastic lymphoma), and endocarditis. Drug effects and interactions that challenge the cardiovascular system are even more prevalent in this population, and careful review and surveillance of medication effects is crucial as is careful selection of highly active antiretroviral therapy. A focused assessment and understanding of disease prevalence and presentation is needed as symptoms may be non-specific and cardiovascular physical examination findings indeterminate due to co-morbid conditions in the patient population now living with chronic HIV infection.
authors.affiliation: University of Maryland School of Medicine, University of Maryland Comprehensive Heart Center, Baltimore, USA.
authors.forename: Stacy D
authors.initials: SD
authors.lastname: Fisher
authors.forename: Brinder S
authors.initials: BS
authors.lastname: Kanda
authors.forename: Tracie L
authors.initials: TL
authors.lastname: Miller
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lipshultz
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D015995:Prevalence
chemical_list: D019380:Anti-HIV Agents