title: Identifying candidate genes for Parkinson's disease by integrative genomics method.
abstract: BACKGROUND
  The recent studies of Parkinson's disease (PD) indicate that genetics and environmental factors may play an important role in developing of PD. Nowadays, the cell death and cell adhesion are pathogenetic mechanisms which could be related with PD. On the basis of relationship of those mechanisms with PD, the aim of this study was to identify new candidate genes for PD by integration of results of transcriptomics studies and results obtained by Biomedical Discovery Support System (BITOLA).
  
  
  METHODS
  For the detection of functional relationship between potential candidate gene and pathogenetic mechanisms associated with PD, we designed strategy of integration of results of transcriptomics studies with discovery approach in bibliographic data bases and BITOLA. Data of chromosome location, tissue-specific expression, function of potential candidate genes and their association with genetics disorders were obtained from Medline, Locus Link, Gene Cards and OMIM.
  
  
  RESULTS
  Integration and comparison of results obtained using the BITOLA system and analysis of transcriptomics studies identified six genes (MAPT, UCHL1, NSF, CDC42, PARK2 and GFPT1) that occur simultaneously in both group of results. The function of genes NSF, CDC42 and GFPT1 in the pathogenesis of PD has not been studied yet.
  
  
  CONCLUSIONS
  According to our result that aforementioned genes appeared in both groups of results and partially match the criteria set for the selection of candidate genes and their potential role in the development of PD, they should be tested by methods specifically intended for those three genes.
authors.affiliation: Department of Genetics, Faculty of Science, University of Tuzla, Tuzla, Bosnia and Herzegovina amela.jusic@untz.ba
authors.forename: Amela
authors.initials: A
authors.lastname: Karic
authors.forename: Rifet
authors.initials: R
authors.lastname: Terzic
authors.forename: Alen
authors.initials: A
authors.lastname: Karic
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D016206:Databases, Bibliographic; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000502:physiology*; D006801:Humans; D046228:Microarray Analysis / Q000379:methods; D010300:Parkinson Disease / Q000235:genetics*; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins / Q000502:physiology*; D020764:cdc42 GTP-Binding Protein / Q000502:physiology*
chemical_list: D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; C497511:GFPT1 protein, human; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D020764:cdc42 GTP-Binding Protein