title: Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo.
abstract: Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.
authors.affiliation: School of Chemistry, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Kitty Ka Kit
authors.initials: KK
authors.lastname: Ho
authors.forename: Nerida
authors.initials: N
authors.lastname: Cole
authors.forename: Renxun
authors.initials: R
authors.lastname: Chen
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Willcox
authors.forename: Scott A
authors.initials: SA
authors.lastname: Rice
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D013207:Staphylococcal Skin Infections / Q000382:microbiology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D011108:Polymers; D011758:Pyrroles; D000099166:Polyacrylamides; C013231:pyrroline