title: A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp.
abstract: While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1-8 against a panel of human and mammalian cell lines are discussed.
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.|Defence Science & Technology Organisation, 506 Lorimer St. Fishermans Bend, Victoria 3207, Australia.
authors.forename: Simon P B
authors.initials: SPB
authors.lastname: Ovenden
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.|ACD Labs UK, Building A, Trinity Court, Wokingham Road, Bracknell, Berkshire RG42 1PL, UK.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Nielson
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.|Advanced Analytical Centre, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Catherine H
authors.initials: CH
authors.lastname: Liptrot
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Willis
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Tapiolas
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.|College of Pharmacy, University of Hawaii, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.affiliation: Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.
authors.forename: Cherie A
authors.initials: CA
authors.lastname: Motti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001315:Australia; D001381:Azepines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; D054659:Diketopiperazines; D010080:Oxazoles; D010456:Peptides, Cyclic; C571463:cyclo-(4-S-hydroxy-R-proline-R-isoleucine)