title: Hypertension-related factors in patients with active and inactive acromegaly.
abstract: BACKGROUND
  There are several complications of the cardiovascular system caused by acromegaly, especially hypertension.
  
  
  OBJECTIVE
  To evaluate hypertension characteristics in patients with cured/controlled acromegaly and with the active disease.
  
  
  METHODS
  Cross-sectional study of the follow-up of forty-four patients with acromegaly submitted to clinical evaluation, laboratory tests and cardiac ultrasound. Patients with cured and controlled disease were evaluated as one group, and individuals with active disease as second one.
  
  
  RESULTS
  Forty-seven percent of the patients had active acromegaly, and these patients were younger and had lower blood pressure levels than subjects with controlled/cured disease. Hypertension was detected in 50% of patients. Subjects with active disease showed a positive correlation between IGF-1 and systolic and diastolic blood pressure levels (r = 0.48, p = 0.03; and r = 0.42, p = 0.07, respectively), and a positive correlation between IGF-1 and urinary albumin excretion (UAE) rates. In patients with active disease, IGF-1 was a predictor of systolic blood pressure, although it was not independent of UAE rate. For individuals with cured/controlled disease, waist circumference and triglycerides were the predictors associated with systolic and diastolic blood pressure.
  
  
  CONCLUSIONS
  Blood pressure (BP) levels in patients with active acromegaly dependent of the GH excess. However, once thedisease becomes controlled and IGF-1 levels decrease, their blood pressure levels are depend on the other cardiovascular riskfactors [corrected].
authors.affiliation: Programa de Pós-graduação em Ciências Médicas, Endocrinologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Fedrizzi
authors.forename: Ticiana Costa
authors.initials: TC
authors.lastname: Rodrigues
authors.forename: Fabíola
authors.initials: F
authors.lastname: Costenaro
authors.forename: Rosana
authors.initials: R
authors.lastname: Scalco
authors.forename: Mauro Antônio
authors.initials: MA
authors.lastname: Czepielewski
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013599:Systole / Q000502:physiology
chemical_list: D015415:Biomarkers; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I