title: Molecular bottlebrushes with polypeptide backbone prepared via ring-opening polymerization of NCA and ATRP.
abstract: A new type of molecular bottlebrush with poly-L-lysine (PLL) as backbone was synthesized via ROP followed by ATRP. A Nϵ-bromoisobutyryl functionalized Nα-CBZ-L-lysine was firstly synthesized and converted in polymerizable α-amino acid N-carboxyanhydride (NCA), which was then polymerized using Ni(0) transition metal complex to give well-defined bromo-functionalized homopolypeptide (PBrLL), from which we prepared two types of polypeptide bottlebrushes with polystyrene and poly(oligoethylene glycol methacrylate) as side-chains. PBrLL macroinitiator was demonstrated to have high initiation efficiency for ATRP, which allowed good control over side-chain length. CD and FTIR characterization revealed that both PBrLL macroinitiator and PLL backbone of bottlebrushes adopted α-helical conformation in appropriate solvents.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000812:Anhydrides; D008689:Methacrylates; D010455:Peptides; D011108:Polymers; D011107:Polylysine; C005044:hydroxyethyl methacrylate