title: Maternal deletion allele of Angiotensin-converting enzyme gene is associated with fetal growth restriction.
abstract: To investigate the correlation between maternal and fetal angiotensin-converting enzyme gene insertion or deletion polymorphism and birth size, angiotensin-converting enzyme gene insertion or deletion polymorphisms of 470 Japanese pairs of mothers and infants were genotyped. The relationships between maternal and fetal angiotensin-converting enzyme gene insertion or deletion polymorphisms and birth sizes (weight, length, head circumference, and the incidence of small-for-gestational age status) were analyzed. No relationship between fetal angiotensin-converting enzyme genotype and birth size was observed. In contrast, the incidence of small-for-gestational age status in babies whose mothers had 1 or 2 deletion alleles was greater than that in babies whose mothers had 2 insertion alleles (7% vs 3%, P  =  0.045). Maternal deletion allele of angiotensin-converting enzyme is associated with fetal growth restriction in the Japanese normal population.
authors.affiliation: Department of Pediatrics, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan. eiki5p@asahikawamed.ac.jp
authors.forename: Eiki
authors.initials: E
authors.lastname: Nakamura
authors.forename: Toshio
authors.initials: T
authors.lastname: Okamoto
authors.forename: Ken
authors.initials: K
authors.lastname: Nagaya
authors.forename: Tokitsugi
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001724:Birth Weight / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D017384:Sequence Deletion
chemical_list: D007703:Peptidyl-Dipeptidase A