title: Semantic Processing and Thought Disorder in Childhood-Onset Schizophrenia: Insights from fMRI.
abstract: Impairments in language processing and thought disorder are core symptoms of schizophrenia. Here we used fMRI to investigate functional abnormalities in the neural networks subserving sentence-level language processing in childhood-onset schizophrenia (COS). Fourteen children with COS (mean age: 13.34; IQ: 95) and 14 healthy controls (HC; mean age: 12.37; IQ: 104) underwent fMRI while performing a semantic judgment task previously shown to differentially engage semantic and syntactic processes. We report four main results. First, different patterns of functional specialization for semantic and syntactic processing were observed within each group, despite similar level of task performance. Second, after regressing out IQ, significant between-group differences were observed in the neural correlates of semantic and, to a lesser extent, syntactic processing, with HC children showing overall greater activity than COS children. Third, while these group differences were not related to effects of medications, a significant negative correlation was observed in the COS group between neuroleptic dosage and activity in the left inferior frontal gyrus for the semantic condition. Finally, COS children's level of thought disorder was significantly correlated with task-related activity in language-relevant networks. Taken together, these findings suggest that children with COS exhibit aberrant patterns of neural activity during semantic, and to a lesser extent syntactic, processing and that these functional abnormalities in language-relevant networks are significantly related to severity of thought disorder.
authors.affiliation: Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, California, 90095, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Borofsky
authors.forename: K
authors.initials: K
authors.lastname: McNealy
authors.forename: P
authors.initials: P
authors.lastname: Siddarth
authors.forename: K N
authors.initials: KN
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Dapretto
authors.forename: R
authors.initials: R
authors.lastname: Caplan