title: Synthesis and characterization of the ligand based on benzimidazole and its copper complex: DNA binding and antioxidant activity.
abstract: A new copper(II) complex with formulae of [Cu(buobb)(2)](pic)(2), where buobb stands for the ligand of 1,3-bis(1- butylbenzimidazol-2-yl)-2-oxopropane and pic represents 2,4,6-trinitrophenol, has been synthesized and characterized by elemental analyses, molar conductivity, IR, UV-Vis spectra measurements, and cyclic voltammetry. The crystal structure of the copper(II) complex has been determined by X-ray single-crystal diffraction. The coordination environment around each copper(II) atom can be described as a distorted octahedral geometry. The π-π stacking interactions link the copper(II) complex into a 1D infinite network. The interactions of the ligand and the copper(II) complex with calf thymus DNA (CT-DNA) are investigated by using electronic absorption titration, ethidium bromide-DNA displacement experiments, and viscosity measurements. Additionally, the copper(II) complex's antioxidant properties have been investigated in vitro.
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
authors.forename: Huilu
authors.initials: H
authors.lastname: Wu
authors.forename: Fan
authors.initials: F
authors.lastname: Kou
authors.forename: Fei
authors.initials: F
authors.lastname: Jia
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Jingkun
authors.initials: J
authors.lastname: Yuan
authors.forename: Ying
authors.initials: Y
authors.lastname: Bai