title: Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography.
abstract: Vibratory measurements of the structures of the ear are key to understanding much of the pathology in mouse models of hearing loss. Unfortunately the high-speed sampling required to interrogate the high end of the mouse hearing spectrum is beyond the reach of most optical coherence tomography (OCT) systems. To address this issue, we have developed an algorithm that enables phase-sensitive OCT measurements over the full range of the mouse hearing spectrum (4-90 kHz). The algorithm phase-locks the line-trigger to the acoustic stimulation and then uses interleaved sampling to reconstruct the signal with higher temporal sampling. The algorithm was evaluated by measuring the vibratory response of mouse tympanic membrane to a pure tone stimulus.
authors.affiliation: Department of Biomedical Engineering, Texas A & M University, 337 Zachry Engineering Center, College Station, Texas 77843, USA. apple@tamu.edu
authors.forename: Brian E
authors.initials: BE
authors.lastname: Applegate
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Shelton
authors.forename: Simon S
authors.initials: SS
authors.lastname: Gao
authors.forename: John S
authors.initials: JS
authors.lastname: Oghalai
mesh_terms: D000161:Acoustic Stimulation; D000465:Algorithms; D000818:Animals; D006309:Hearing / Q000502:physiology*; D051379:Mice; D009038:Motion; D055620:Optical Phenomena; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data; D014432:Tympanic Membrane / Q000502:physiology; D014732:Vibration