title: Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas.
abstract: OBJECTIVE
  To highlight recent researches which may show promise for histomolecular classification and new treatments for gliomas.
  
  
  METHODS
  All articles cited in this review were mainly searched from PubMed, which were published in English from 1996 to 2010.
  
  
  METHODS
  Original articles and critical reviews selected were relevant to the isocitrate dehydrogenase-1/2 mutation in gliomas and other tumors.
  
  
  RESULTS
  Extraordinary high rates of somatic mutations in isocitrate dehydrogenase-1/2 occur in the majority of World Health Organization grade II and grade III gliomas as well as grade IV secondary glioblastomas. Isocitrate dehydrogenase-1/2 mutations are associated with younger age at diagnosis and a better prognosis in patients with mutated tumors. The functional role of isocitrate dehydrogenase-1/2 mutations in the pathogenesis of gliomas is still unclear.
  
  
  CONCLUSIONS
  Isocitrate dehydrogenase-1/2 mutations define a specific subtype of gliomas and may have great significance in the diagnosis, prognosis, and treatment of patients with these tumors.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Qi
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D016158:Genes, p53; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D005977:Glutarates / Q000378:metabolism; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics* / Q000502:physiology; D007656:Ketoglutaric Acids / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D009249:NADP / Q000378:metabolism; D060787:Neoplasm Grading; D011379:Prognosis
chemical_list: D005977:Glutarates; D007656:Ketoglutaric Acids; C019417:alpha-hydroxyglutarate; D009249:NADP; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human