title: Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer.
abstract: BACKGROUND
  The presence of thyroid peroxidase antibodies (TPOab) are reported to be associated with improved outcome among breast cancer patients. We evaluated the correlation between TPOab and diagnostic parameters among newly diagnosed breast cancer patients.
  
  
  METHODS
  Three hundred and fourteen newly diagnosed patients with breast cancer, diagnosed and treated in Bethesda Essen between January 2002 and June 2006, were included in this study; 258 (82.2%) without TPOab (≤100 IU/mL) and 56 (17.8%) with TPOab (>100 IU/mL). Blood analysis was performed to measure serum levels of carcinoembryonic antigen (CEA), cancer antigen 15-3 (CA-15-3), free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and TPOab by radioimmunoassay. Data regarding age, tumor size, grading, TNM classification, receptor status, lymph node, and distant metastases were collected and analyzed from patient reports. Statistics were performed using Pearson’s χ2-test and logistic regression analysis.
  
  
  RESULTS
  There were no incidences of distant metastasis among 56 patients with TPOab, whereas 17 (6.6%) of 258 cases without TPOab displayed distant metastases (p=0.04). Logistic regression showed an inverse association of TPOab with CA-15-3 and CEA levels (p<0.001, respectively). Both groups, with and without TPOab, revealed no significant differences with respect to age, tumor size, grading, TNM classification, fT3, fT4, and receptor status. TPOab positive patients had higher TSH levels (2.55±3.58), compared to TPOab negative cases (1.20±1.15) (p<0.001).
  
  
  CONCLUSIONS
  TPOab occurrence is associated with significantly lower frequency of distant metastases in breast cancer. TPOab level inversely correlates with the conventional tumor markers CA-15-3 and CEA.
authors.affiliation: Thyroid Center, Institute of Radiology, Nuclear Medicine and Radiotherapy, Bottrop, Germany.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Farahati
authors.forename: Dirk
authors.initials: D
authors.lastname: Roggenbuck
authors.forename: Elena
authors.initials: E
authors.lastname: Gilman
authors.forename: Martin
authors.initials: M
authors.lastname: Schütte
authors.forename: Elena
authors.initials: E
authors.lastname: Jagminaite
authors.forename: Rasoul
authors.initials: R
authors.lastname: Seyed Zakavi
authors.forename: Thomas
authors.initials: T
authors.lastname: Löning
authors.forename: Eberhard
authors.initials: E
authors.lastname: Heissen
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood* / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood / Q000276:immunology; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008875:Middle Aged; D009362:Neoplasm Metastasis
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D007453:Iodide Peroxidase