title: Putting the pH into phosphatidic acid signaling.
abstract: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
authors.affiliation: Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
authors.forename: John J H
authors.initials: JJ
authors.lastname: Shin
authors.forename: Christopher J R
authors.initials: CJ
authors.lastname: Loewen
mesh_terms: D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010712:Phosphatidic Acids / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010712:Phosphatidic Acids; D011506:Proteins