title: Malondialdehyde in early phase of acute pancreatitis.
abstract: OBJECTIVE
  to assess oxidative stress in acute pancreatitis, its evolution over time and its relationship with the severity of the disease.
  
  
  METHODS
  during a two-year period, patients with acute pancreatitis with less than 24 hours of pain were evaluated. Serum was obtained the first, second and fourth day from admittance, if complications were detected, and after recovery. Malondialdehyde was determined by high performance liquid chromatography. Twenty healthy volunteers constituted the control group. Malondialdehyde between groups was compared with Mann-Whitney and Kruskal-Wallis tests; malondialdehyde evolution was studied with Wilcoxon test.
  
  
  RESULTS
  one hundred and sixty-nine patients were included (91 women, median age 67 years, range 20-95); 33 suffered a severe episode. Malondialdehyde decreased from first to fourth day (0.600 vs. 0.451 vs. 0.343 M, respectively, p < 0.05). When complications were detected, malondialdehyde level was similar to that of first and second day (0.473 M, p > 0.05). In severe attacks malondialdehyde was higher than in control group at day 2 (severe: 0.514; mild: 0.440; control: 0.347 M, p < 0.05 severe vs. control).
  
  
  CONCLUSIONS
  an early oxidative stress is observed in acute pancreatitis. In severe attacks, oxidative stress remains high longer than in mild episodes. The onset of complications is associated with high malondialdehyde concentration.
authors.affiliation: Department of Gastroenterology, Hospital Clínico Universitario de Valencia, Universitat de València, València, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Hernández
authors.forename: María
authors.initials: M
authors.lastname: Miranda
authors.forename: Isabel
authors.initials: I
authors.lastname: Pascual
authors.forename: Vicente
authors.initials: V
authors.lastname: Sanchiz
authors.forename: Pedro
authors.initials: P
authors.lastname: Almela
authors.forename: Ramón
authors.initials: R
authors.lastname: Añón
authors.forename: Esperanza
authors.initials: E
authors.lastname: Cuadrado
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Sanz
authors.forename: Miguel
authors.initials: M
authors.lastname: Mínguez
authors.forename: Francisco
authors.initials: F
authors.lastname: Mora
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Romero
authors.forename: Adolfo
authors.initials: A
authors.lastname: Benages
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D010195:Pancreatitis / Q000097:blood / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde