title: Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review.
abstract: Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.
authors.affiliation: Department of Pediatric Immunology and Hematology, Necker Hospital, AP-HP, Paris, France. Sandrine.leroy@pasteur.fr
authors.forename: Sandrine
authors.initials: S
authors.lastname: Leroy
authors.forename: Despina
authors.initials: D
authors.lastname: Moshous
authors.forename: Olivier
authors.initials: O
authors.lastname: Cassar
authors.forename: Yves
authors.initials: Y
authors.lastname: Reguerre
authors.forename: Minji
authors.initials: M
authors.lastname: Byun
authors.forename: Vincent
authors.initials: V
authors.lastname: Pedergnana
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.forename: Antoine
authors.initials: A
authors.lastname: Gessain
authors.forename: Eric
authors.initials: E
authors.lastname: Oksenhendler
authors.forename: Claire
authors.initials: C
authors.lastname: Fieschi
authors.forename: Nizar
authors.initials: N
authors.lastname: Mahlaoui
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Rivière
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Herbigneaux
authors.forename: Matthias
authors.initials: M
authors.lastname: Muszlak
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Arnaud
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Capucine
authors.initials: C
authors.lastname: Picard
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Sabine
authors.initials: S
authors.lastname: Plancoulaine
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D005871:Castleman Disease / Q000150:complications / Q000473:pathology / Q000821:virology*; D002648:Child; D003241:Consanguinity; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology; D019288:Herpesvirus 8, Human; D006801:Humans