title: Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity.
abstract: The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were larger than those in the other two groups [corrected]. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.
authors.affiliation: United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Matsuzaki
authors.forename: Kuriko
authors.initials: K
authors.lastname: Kagitani-Shimono
authors.forename: Tetsu
authors.initials: T
authors.lastname: Goto
authors.forename: Wakako
authors.initials: W
authors.lastname: Sanefuji
authors.forename: Tomoka
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Saeko
authors.initials: S
authors.lastname: Sakai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uchida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hirata
authors.forename: Ikuko
authors.initials: I
authors.lastname: Mohri
authors.forename: Shiro
authors.initials: S
authors.lastname: Yorifuji
authors.forename: Masako
authors.initials: M
authors.lastname: Taniike
mesh_terms: D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D012001:Hyperacusis / Q000209:etiology / Q000503:physiopathology*; D015225:Magnetoencephalography; D008297:Male