title: Assessment of serum levels resistin in girls with anorexia nervosa. Part I. Relationship between resistin and body mass index.
abstract: OBJECTIVE
  There are only few studies available on blood resistin (RES) levels in patients with anorexia nervosa (AN), which revealed scarce results, however it has been demonstrated that RES mRNA expression in adipose tissue of these patients is increased. The aim of this study is: 1) the evaluation of serum resistin levels in girls with AN and determination a threshold value differentiating these patients from healthy subjects; 2) analysis of the relationship between serum resistin levels and BMI in examined subjects.
  
  
  METHODS
  Serum RES concentration has been assayed using ELISA kit in 195 adolescent girls: 87 with restrictive AN (mean BMI-SDS: -2.65 ± 0.2), 17 with not otherwise specified eating disorders (NOS) (mean BMI-SDS: -1.4 ± 0.68), 30 with simple obesity (OB) (mean BMI-SDS: 6.91 ± 1.23) and 61 healthy (mean BMI-SDS: -0.18 ± 0.54).
  
  
  RESULTS
  Mean serum RES concentration in AN (2.8 ± 0.6 ng/ml) and NOS (3.1 ± 0.9 ng/ml) were significantly lower (p<0.0001) than in OB and H groups (4.8 ± 0.5 and 4.1 ± 0.4 ng/ml respectively). After corrected for BMI, RES values in AN were similar as in H subjects, but significantly higher (p<0.005) in comparison to OB group. ROC curve analysis revealed that 3.87 ng/ml is the threshold value of RES serum concentration differentiating AN from H girls (specificity 100%, sensitivity 80%). No significant correlations between BMI and serum resistin concentration are found in AN group, although a significant positive correlation has been established for all examined subjects.
  
  
  CONCLUSIONS
  Additional adaptive mechanisms may be involved in regulation of RES levels in adolescent girls with AN.
authors.affiliation: Department of Paediatrics in Zabrze, Silesian University of Medicine in Katowice, Poland. smina@poczta.onet.pl.
authors.forename: Katarzyna T
authors.initials: KT
authors.lastname: Ziora
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Oswiecimska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Swietochowska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stojewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Gorczyca
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rojewska
authors.forename: Karolina
authors.initials: K
authors.lastname: Ziora-Jakutowicz
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepanska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000503:physiopathology*; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D012372:ROC Curve; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: C499624:RETN protein, human; D052243:Resistin