title: Electrogastrography in experimental pigs: the influence of gastrointestinal injury induced by dextran sodium sulphate on porcine gastric erythromycin-stimulated myoelectric activity.
abstract: OBJECTIVE
  Electrogastrography (EGG) is a non-invasive investigation of gastric myoelectrical activity. The aim of study was to evaluate the impact of erythromycin on EGG in gastrointestinal toxic injury induced by dextran sodium sulphate (DSS) in experimental pigs.
  
  
  METHODS
  The experiments were carried out on 12 adult pigs (weighing 30-35 kg). EGG was recorded using Digitrapper equipment (Synectics Medical AB, Stockholm). Running spectrum activity was used for EGG evaluation. There were two groups of animals: Group I: 6 controls with erythromycin administration (1,600 mg intragastrically); Group II: 6 animals treated with DSS (for 5 days, 0.25 g/kg per day in a dietary bolus) followed by erythromycin administration. Baseline and subsequent six separate 30-minute EGG-recordings (from time 0 to 360 min) were accomplished in each animal.
  
  
  CONCLUSIONS
  A total of 84 records were analysed. Baseline dominant frequency of slow waves was fully comparable in both groups. In Group I, there was a significant increase in dominant frequency after erythromycin administration (maximum between 240-360 min). There was a flat non-significant and delayed increase in dominant frequency after erythromycin administration in Group II. The difference between Group I and II at particular time intervals was not significant but a diverse trend was evident. EGG recording enables us to register a gastric myoelectrical effect of prokinetic drugs. Erythromycin induced a significant increase in the dominant frequency of slow waves. DSS caused toxic injury to the porcine gastrointestinal tract responsible for the delayed and weaker myoelectrical effect of erythromycin in experimental animals.
authors.affiliation: 2nd Department of Medicine, Charles University in Prague, Faculty of Medicine in Hradec Králové, University Teaching Hospital, Hradec Kralove, Czech Republic. tacheci@fnhk.cz
authors.forename: Ilja
authors.initials: I
authors.lastname: Tachecí
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Kvetina
authors.forename: Martin
authors.initials: M
authors.lastname: Kunes
authors.forename: Jithinraj
authors.initials: J
authors.lastname: Edakkanambeth Varayil
authors.forename: Shahzad Marghoob
authors.initials: SM
authors.lastname: Ali
authors.forename: Michal
authors.initials: M
authors.lastname: Pavlik
authors.forename: Marcela
authors.initials: M
authors.lastname: Kopacova
authors.forename: Stanislav
authors.initials: S
authors.lastname: Rejchrt
authors.forename: Jan
authors.initials: J
authors.lastname: Bures
authors.forename: Miloslav
authors.initials: M
authors.lastname: Pleskot
mesh_terms: D000818:Animals; D016264:Dextran Sulfate; D004353:Drug Evaluation, Preclinical; D004576:Electromyography / Q000379:methods / Q000662:veterinary; D055724:Electrophysiological Phenomena / Q000187:drug effects; D004917:Erythromycin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000293:injuries; D023421:Models, Animal; D013270:Stomach / Q000187:drug effects* / Q000293:injuries / Q000502:physiology*; D034421:Sus scrofa
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin; D016264:Dextran Sulfate