title: Assessment of serum levels resistin in girls with anorexia nervosa.  Part II. Relationships between serum levels of resistin and thyroid, adrenal and gonadal hormones.
abstract: OBJECTIVE
  Thyroid, adrenal glands and gonadal hormones play a role in maintaining metabolic homeostasis of the body via the receptors located in the adipose tissue. The correlations between serum resistin (RES) and function of other hormonal axes in patients with AN have not been established, yet. Therefore, the aim of this study is: 1) assessment of concentrations of thyroid hormones (FT4, TSH), adrenal hormones (ACTH, cortisol), sex hormones (LH, FSH, estradiol, testosterone); 2) establishing their relationship with BMI and 3) analysis of correlations between examined hormones and RES serum concentrations in adolescent female patients with AN.
  
  
  METHODS
  Serum RES (ELISA) and fT4, TSH, ACTH, LH, FSH, estradiol and testosterone (ECLIA) concentrations have been assayed in 195 adolescent girls: 87 with restrictive AN, 17 with not otherwise specified eating disorders (NOS), 30 with simple obesity (OB) and 61 healthy (H) subjects.
  
  
  RESULTS
  Mean serum FT4, LH and estradiol concentrations were significantly lower (p=0.015; p<0.0001; p<0.0001, respectively) in AN than in OB group, and cortisol increased (p<0.001) compared to OB and H subjects. In all examined subjects BMI correlated positively (p<0.0001) with LH (r=0.61) and estradiol (r=0.30), and negatively with cortisol (r=-0.35; p=0.008). Also the significant positive relationship between serum RES and FT4 (r=0.34), LH (r=0.57) as well as estradiol (r=0.28) was observed, whereas serum cortisol correlated negatively with RES (r=-0.40).
  
  
  CONCLUSIONS
  Changes in resistin serum concentrations in eating disorders may be involved in the altered regulation of hypothalamic-pituitary-adrenal, thyroid and gonadal axes.
authors.affiliation: Department of Paediatrics, Silesian Medical University, Zabrze, Poland.
authors.forename: Katarzyna T
authors.initials: KT
authors.lastname: Ziora
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Oswiecimska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Swietochowska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stojewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Gorczyca
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rojewska
authors.forename: Karolina
authors.initials: K
authors.lastname: Ziora-Jakutowicz
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepanska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000503:physiopathology*; D002648:Child; D004703:Endocrine System / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D010913:Pituitary-Adrenal System / Q000502:physiology; D052243:Resistin / Q000097:blood*; D013739:Testosterone / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D055815:Young Adult
chemical_list: D006728:Hormones; C499624:RETN protein, human; D052243:Resistin; D013739:Testosterone; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone