title: Seroprevalence of hepatitis E among Iranian renal transplant recipients.
abstract: BACKGROUND
  Renal transplant recipients are known to be susceptible to viral infections, with more severe clinical presentations compared to healthy persons. Hepatitis E is generally a self-limited disease, which is caused by hepatitis E virus. Recently, hepatitis E has become more important in organ transplant recipients, because of new findings regarding the potential for chronic infections in this patient group.
  
  
  OBJECTIVE
  This study aimed to evaluate the seroprevalence of anti-HEV IgG among kidney transplant recipients in Urmia, in the north-western region of Iran.
  
  
  METHODS
  91 patients were selected randomly from amongst patients who had undergone kidney transplantation in Urmia, Iran. Each patient was tested for the presence of anti-HEV IgG antibody using an enzyme-linked immunosorbent assay (ELISA, Dia.Pro; Diagnostic Bioprobes, Italy).
  
  
  RESULTS
  28 subjects (30.8%) were seropositive for anti-HEV IgG. Seropositive patients were generally older than seronegative patients (P = 0.009). There was no correlation between HEV infection and the level of education (P = 0.206), the history of blood transfusion (P = 0.164), or history of pre-transplantation hemodialysis (P = 0.228). There was no significant difference in the serum alanine aminotransferase (ALT) levels of the anti-HEV seropositive and seronegative patients. Multinomial logistic regression analysis indicated no significant relationship between HEV infection and increase in ALT levels, even after controlling for treatment with azathioprine (P = 0.79, OR = 1.12; 95% CI: 0.45-2.76).
  
  
  CONCLUSIONS
  The anti-HEV IgG antibody has a high prevalence in Iranian kidney transplant recipients, and it is significantly higher in comparison with previous studies in the general population or in hemodialysis patients.
authors.affiliation: Department of Microbiology and Immunology, Urmia University of Medical Sciences, Urmia, IR Iran.
authors.forename: Zakieh
authors.initials: Z
authors.lastname: Rostamzadeh Khameneh
authors.forename: Nariman
authors.initials: N
authors.lastname: Sepehrvand
authors.forename: Sima
authors.initials: S
authors.lastname: Masudi