title: A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines.
abstract: A general procedure for the synthesis of the title compounds has been devised starting from the available 2-halophenylethyl azides, by means of click reactions with trimethylsilylacetylene or 1-trimethylsilyl-1,3-butadiyne followed by a transition metal-catalyzed functionalization of C-H bond. A further extension of this procedure led us to devise the synthesis of more complex 4,4'-bitriazole-fused dihydroisoquinolines.
authors.affiliation: Dipartimento di Chimica, Università di Bari Aldo Moro, via Orabona 4, 70126, Bari, Italy. fianda@chimica.uniba.it
authors.forename: Vito
authors.initials: V
authors.lastname: Fiandanese
authors.forename: Silvia
authors.initials: S
authors.lastname: Maurantonio
authors.forename: Angela
authors.initials: A
authors.lastname: Punzi
authors.forename: Giacomo G
authors.initials: GG
authors.lastname: Rafaschieri
mesh_terms: D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007546:Isoquinolines; D014230:Triazoles