title: Development and structure of a novel barrier membrane composed of drug-loaded poly(lactic-co-glycolic acid) particles for guided bone regeneration.
abstract: A novel barrier membrane composed of poly(lactic-co-glycolic acid) particles loaded with dexamethasone (DEX) as a bioactive molecule was produced via a modified nanoprecipitation method without any mixing. The particle membranes had a bilayer structure: one side was smooth and had a compact surface that was connected to larger particles, while the opposite side was rough, porous and connected to smaller particles. Additionally, a cross-section of the particle membrane had a porous structure with nano and micro sized irregular pores. Process optimization revealed that NaCl concentration in the water phase, with acetone as solvent and water as a non-solvent, played critical roles in determining the properties of the particle membranes, such as DEX encapsulation efficiency, thickness and surface morphologies of the particle membranes. A novel barrier membrane containing DEX using polymer particle drug capture technology has been successfully developed.
authors.affiliation: Regional Center for Oral Disease Regulation of the Aged, School of Dentistry, Chosun University, Gwangju, Republic of Korea.
authors.forename: Jun-Sik
authors.initials: JS
authors.lastname: Son
authors.forename: Su-Gwan
authors.initials: SG
authors.lastname: Kim
authors.forename: Seung-Chan
authors.initials: SC
authors.lastname: Jin
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Piao
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ji-Su
authors.initials: JS
authors.lastname: Oh
authors.forename: Chun-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Byung-Hoon
authors.initials: BH
authors.lastname: Kim
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Jeong
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001861:Bone Regeneration / Q000187:drug effects*; D003907:Dexamethasone / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles; D011100:Polyglycolic Acid / Q000008:administration & dosage* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone