title: 2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.
abstract: Two novel 2-arylbenzofuran dimers, morusyunnansins A and B (1 and 2), two new biflavonoids, morusyunnansins C and D (3 and 4), two new flavans, morusyunnansins E and F (5 and 6), and four known flavans (7-10) were isolated from the leaves of Morus yunnanensis. Compounds 5-8 showed potent inhibitory effects on mushroom tyrosinase with IC(50) values ranging from 0.12 ± 0.02 to 1.43 ± 0.43 μM.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Wu
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yu
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D000363:Agaricales / Q000201:enzymology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D044946:Biflavonoids; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C570754:morusyunnansin A; C570755:morusyunnansin B; C570756:morusyunnansin C; C570757:morusyunnansin D; C570759:morusyunnansin E; C570760:morusyunnansin F; D014442:Monophenol Monooxygenase