title: Comparable analysis of outcomes for allogeneic peripheral blood stem cell transplantation from matched related and matched unrelated donors in acute myeloid leukemia.
abstract: This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7% in the unrelated PBSCT group. The cumulative incidence of extensive chronic GVHD was also higher in the unrelated PBSCT group (19.5%) than in the related PBSCT group (8.9%). The overall survival rate at 4 years was 62.4 ± 5.4 and 53.8 ± 1.2% (p = 0.535) in the related and unrelated PBSCT group, respectively. In a multivariate analysis, unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 3.019, p = 0.027). Unfavorable cytogenetics and the disease status at the time of transplantation were found to be related to overall survival. In the case of high-risk AML, the survival rate and relapse incidence were significantly better in the matched unrelated PBSCT group (p = 0.047 and 0.039, respectively). In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT.
authors.affiliation: Department of Hematology, Kyungpook National University Hospital, Daegu, South Korea.
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Lee
authors.forename: Byung Woog
authors.initials: BW
authors.lastname: Kang
authors.forename: Joon Ho
authors.initials: JH
authors.lastname: Moon
authors.forename: Yee Soo
authors.initials: YS
authors.lastname: Chae
authors.forename: Jong Gwang
authors.initials: JG
authors.lastname: Kim
authors.forename: Joo Seop
authors.initials: JS
authors.lastname: Jung
authors.forename: Goon-Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Deog-Yeon
authors.initials: DY
authors.lastname: Jo
authors.forename: Yeo Kyeoung
authors.initials: YK
authors.lastname: Kim
authors.forename: Hyeoung Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hun-Mo
authors.initials: HM
authors.lastname: Ryoo
authors.forename: Hyeon Seok
authors.initials: HS
authors.lastname: Eom
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Le
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Joo
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Moo Rim
authors.initials: MR
authors.lastname: Park
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
authors.forename: Sang-Kyun
authors.initials: SK
authors.lastname: Sohn
mesh_terms: D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000401:mortality; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate; D061349:Unrelated Donors