title: Posttransplant lymphoproliferative disorder with lung involvement in a renal transplant recipient.
abstract: Posttransplant lymphoproliferative disorder is one of the most important complications of solid-organ transplant in terms of malignancy. Here, we report a case of Epstein-Barr-virus-negative posttransplant lymphoproliferative disorder of the T-cell type, involving the lung, in a renal transplant recipient. A 23-year-old woman received a living-related renal transplant in 2002. She presented with a 6-month history of weight loss, malaise, night sweats, and lymphadenopathy 6 years after the transplant. Chest radiograph showed miliary opacities. We performed a biopsy of the submandibular mass and computed-tomography-guided transthoracic needle biopsy of the lung. Pathological investigation of lymphadenopathy and lung were inconsistent with posttransplant lymphoproliferative disorder of T-cell type. After the diagnosis of posttransplant lymphoproliferative disorder, her immunosuppressive regimen was modified, and she was treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, ifosfamide, carboplatin, and etoposide chemotherapies, which resulted in partial remission. Posttransplant lymphoproliferative disorders may be seen as an atypical presentation; the differential diagnosis should be thought of pulmonary infiltrates in renal transplant recipients.
authors.affiliation: Department of Internal Medicine, Gazi University Hospital, Ankara, Turkey. emelisiktas@yahoo.com
authors.forename: Emel Isiktas
authors.initials: EI
authors.lastname: Mirza
authors.forename: Ruya
authors.initials: R
authors.lastname: Mutluay
authors.forename: Elif
authors.initials: E
authors.lastname: Suyani
authors.forename: Gulay Ulusal
authors.initials: GU
authors.lastname: Okyay
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyurek
authors.forename: Sahika Zeynep
authors.initials: SZ
authors.lastname: Aki
authors.forename: Ulver
authors.initials: U
authors.lastname: Derici
authors.forename: Turgay
authors.initials: T
authors.lastname: Arinsoy
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D015641:Radiography, Interventional / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents