title: Orbital apex syndrome associated with herpes zoster ophthalmicus.
abstract: We report our findings for a patient with orbital apex syndrome associated with herpes zoster ophthalmicus. Our patient was initially admitted to a neighborhood hospital because of nausea and loss of appetite of 10 days' duration. The day after hospitalization, she developed skin vesicles along the first division of the trigeminal nerve, with severe lid swelling and conjunctival injection. On suspicion of meningoencephalitis caused by varicella zoster virus, antiviral therapy with vidarabine and betamethasone was started. Seventeen days later, complete ptosis and ophthalmoplegia developed in the right eye. The light reflex in the right eye was absent and anisocoria was present, with the right pupil larger than the left. Fat-suppressed enhanced T1-weighted magnetic resonance images showed high intensity areas in the muscle cone, cavernous sinus, and orbital optic nerve sheath. Our patient was diagnosed with orbital apex syndrome, and because of skin vesicles in the first division of the trigeminal nerve, the orbital apex syndrome was considered to be caused by herpes zoster ophthalmicus. After the patient was transferred to our hospital, prednisolone 60 mg and vidarabine antiviral therapy was started, and fever and headaches disappeared five days later. The ophthalmoplegia and optic neuritis, but not the anisocoria, gradually resolved during tapering of oral therapy. From the clinical findings and course, the cause of the orbital apex syndrome was most likely invasion of the orbital apex and cavernous sinus by the herpes virus through the trigeminal nerve ganglia.
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Osaka, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Kurimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tonari
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ishizaki
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Monta
authors.forename: Saori
authors.initials: S
authors.lastname: Hirata
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oku
authors.forename: Jun
authors.initials: J
authors.lastname: Sugasawa
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Ikeda