title: Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans.
abstract: This report characterizes an aqueous isolate (SBD.4) of one of the most broadly used Chinese medicinal herbs, Angelica sinensis, from the perspective of its application in skin and wound care. SBD.4 has been chemically defined and was found to increase the strength of healed wounds in retired breeder (older) rats. Furthermore, the mechanism of action of this Angelica sinensis isolate was tested in the zebrafish angiogenesis model, and in human skin substitutes by DNA microarray, revealing a bioactivity profile consistent with skin repair and regeneration. When combined with several types of wound dressings, SBD.4 increased type I collagen production in human dermal fibroblasts, and when formulated in nanosilver hydrocolloid dressing, it was found effective in chronic ulcer management in humans, demonstrating that botanical high-tech wound dressings can be successfully developed to improve the treatment of chronic lesions in humans.
authors.affiliation: Sunny BioDiscovery, 972 E. Main Str. Santa Paula CA, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Joel
authors.initials: J
authors.lastname: Deneau
authors.forename: Ginny O L
authors.initials: GO
authors.lastname: Che
authors.forename: Shang
authors.initials: S
authors.lastname: Li
authors.forename: Frederic
authors.initials: F
authors.lastname: Vagnini
authors.forename: Parastoo
authors.initials: P
authors.lastname: Azadi
authors.forename: Roberto
authors.initials: R
authors.lastname: Sonon
authors.forename: Ravi
authors.initials: R
authors.lastname: Ramjit
authors.forename: Simon M Y
authors.initials: SM
authors.lastname: Lee
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bojanowski
mesh_terms: D043925:Angiogenesis Inducing Agents; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D047070:Bandages, Hydrocolloid; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000627:therapeutic use; D012883:Skin Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects* / Q000235:genetics; D015027:Zebrafish / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents; D000891:Anti-Infective Agents, Local; D024042:Collagen Type I; D024061:Collagen Type III; D004365:Drugs, Chinese Herbal; C516837:SBD.4A herbal preparation; D012834:Silver