title: [Surgical management of Pyoderma gangrenosum].
abstract: Pyoderma gangrenosum is a rare affection of unknown etiology, which is often associated with systemic diseases such as chronic inflammatory bowel disease, hematologic disorders, carcinomas and arthritis. Treatment may include topical corticosteroids or calcineurin inhibitors in combination with systemic corticosteroids, cyclosporine A, azathioprine, cyclophosphamide, mycophenolate mofetil, intravenous immunoglobulins or monoclonal antibodies against TNFα but all these approaches are off-label. Surgical therapy is difficult because of pathergy. Nevertheless, after having stopped the inflammation, the ulcers can be treated by split thickness skin grafts and simultaneous immunosuppression. We present three cases with successful surgical treatment.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig- Maximilians-Universität München und Städtisches Klinikum München GmbH, Klinik Thalkirchner Strasse, Deutschland. isabell.sick@med.uni-muenchen.de
authors.forename: I
authors.initials: I
authors.lastname: Sick
authors.forename: B
authors.initials: B
authors.lastname: Trautner
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000473:pathology* / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome