title: Adaptation of genotype 3 hepatitis E virus in Eastern China and inverse correlation with genotype 4 hepatitis E virus.
abstract: We studied the distribution and development of hepatitis E virus (HEV) genotypes 3 and 4 in pig farms located within the Shanghai metropolitan area. A total of 1,487 swine fecal samples were collected from 39 pig farms during 2009-2010. The average incidence rates for genotype 3 and genotype 4 HEV were 10.6 and 9.3%, respectively. The frequencies of genotype 3 and genotype 4 HEV among the farms were inversely related (r = -0.7423), suggesting that the two genotypes competed within the environmental niche provided by the porcine host. In addition, all of the farms tested positive for both genotype 3 and genotype 4 HEV, indicating that the former is becoming more prevalent in the Shanghai area. The overall HEV incidence rate during 2009-2010 was 20%, which supports the existence of homeostasis within the porcine HEV reservoir.
authors.affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Si
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shijuan
authors.initials: S
authors.lastname: Dong
authors.forename: Ruisong
authors.initials: R
authors.lastname: Yu
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Shen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D005243:Feces / Q000821:virology; D005838:Genotype; D016751:Hepatitis E / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D015994:Incidence; D017720:Molecular Epidemiology; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000821:virology*
chemical_list: D012367:RNA, Viral