title: Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.
authors.affiliation: Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. cskarke@mail.med.upenn.edu
authors.forename: Carsten
authors.initials: C
authors.lastname: Skarke
authors.forename: Karina
authors.initials: K
authors.lastname: Kuczka
authors.forename: Lars
authors.initials: L
authors.lastname: Tausch
authors.forename: Oliver
authors.initials: O
authors.lastname: Werz
authors.forename: Tanja
authors.initials: T
authors.lastname: Rossmanith
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Barrett
authors.forename: Sebastian
authors.initials: S
authors.lastname: Harder
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Holtmeier
authors.forename: Joachim A
authors.initials: JA
authors.lastname: Schwarz
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D029743:Boswellia; D056649:Cathepsin G / Q000378:metabolism; D003198:Computer Simulation; D018592:Cross-Over Studies; D015777:Eicosanoids / Q000097:blood; D005215:Fasting / Q000502:physiology; D018565:Food-Drug Interactions; D006801:Humans; D008297:Male; D062407:Meals; D008954:Models, Biological; D010936:Plant Extracts / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D010974:Platelet Aggregation / Q000187:drug effects; D014315:Triterpenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: C447943:11-keto-boswellic acid; D015777:Eicosanoids; D010936:Plant Extracts; D014315:Triterpenes; D056649:Cathepsin G