title: Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system.
abstract: This review focuses on the biological functions and signalling pathways activated by Lymphotoxin α (LTα)/Lymphotoxin β (LTβ) and their receptor LTβR. Genetic mouse models shed light on crucial roles for LT/LTβR to build and to maintain the architecture of lymphoid organs and to ensure an adapted immune response against invading pathogens. However, chronic inflammation, autoimmunity, cell death or cancer development are disorders that occur when the LT/LTβR system is twisted. Biological inhibitors, such as antagonist antibodies or decoy receptors, have been developed and used in clinical trials for diseases associated to the LT/LTβR system. Recent progress in the understanding of cellular trafficking and NF-κB signalling pathways downstream of LTα/LTβ may bring new opportunities to develop therapeutics that target the pathological functions of these cytokines.
authors.affiliation: University of Liège, Belgium, GIGA-Research, Unit of Molecular Immunology and Signal Transduction, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Remouchamps
authors.forename: Layla
authors.initials: L
authors.lastname: Boutaffala
authors.forename: Corinne
authors.initials: C
authors.lastname: Ganeff
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Dejardin
mesh_terms: D000818:Animals; D016923:Cell Death; D015870:Gene Expression; D006801:Humans; D053361:Lymphotoxin alpha1, beta2 Heterotrimer / Q000737:chemistry / Q000276:immunology*; D053259:Lymphotoxin beta Receptor / Q000737:chemistry / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D053308:Lymphotoxin-beta / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D016328:NF-kappa B / Q000276:immunology; D017434:Protein Structure, Tertiary; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000737:chemistry / Q000276:immunology; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000737:chemistry / Q000276:immunology; D015398:Signal Transduction
chemical_list: D053361:Lymphotoxin alpha1, beta2 Heterotrimer; D053259:Lymphotoxin beta Receptor; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta; D016328:NF-kappa B; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II