title: Selective control of gliding microtubule populations.
abstract: First lab-on-chip devices based on active transport by biomolecular motors have been demonstrated for basic detection and sorting applications. However, to fully employ the advantages of such hybrid nanotechnology, versatile spatial and temporal control mechanisms are required. Using a thermo-responsive polymer, we demonstrate the selective starting and stopping of modified microtubules gliding on a kinesin-1-coated surface. This approach allows the self-organized separation of multiple microtubule populations and their respective cargoes.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Dresden, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Korten
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Birnbaum
authors.forename: Dirk
authors.initials: D
authors.lastname: Kuckling
authors.forename: Stefan
authors.initials: S
authors.lastname: Diez
mesh_terms: D016547:Kinesins / Q000737:chemistry* / Q000648:ultrastructure*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008870:Microtubules / Q000737:chemistry* / Q000648:ultrastructure*; D020409:Molecular Motor Proteins / Q000737:chemistry*; D009038:Motion
chemical_list: C488101:KIF5B protein, human; D020409:Molecular Motor Proteins; D016547:Kinesins