title: Structural organization of the kinetochore-microtubule interface.
abstract: Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States. jennifer.deluca@colostate.edu
authors.forename: Jennifer G
authors.initials: JG
authors.lastname: DeLuca
authors.forename: Andrea
authors.initials: A
authors.lastname: Musacchio
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000737:chemistry* / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry* / Q000378:metabolism*; D008938:Mitosis; D008941:Spindle Apparatus / Q000737:chemistry / Q000378:metabolism