title: The frontostriatal circuitry and behavioral complications in PD.
abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder traditionally associated with motor symptoms. However, a number of reports have described also deficits across a range of cognitive functions and behavioral complications during the progression of the disease. Here, we summarize recent observations that may help us to understand the underlying neuronal correlates of behavioral complications in PD. We will report findings from cutting-edge imaging technology which in the last few years have provided the bulk of information on the neurobiological underpinnings of non-motor symptoms in PD.
authors.affiliation: Movement Disorder Unit & E.J. Sofra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada.
authors.forename: Joyce
authors.initials: J
authors.lastname: Tang
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Strafella
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D019964:Mood Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D009415:Nerve Net / Q000503:physiopathology*; D010300:Parkinson Disease / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology