title: Induced neuronal cells: how to make and define a neuron.
abstract: Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Yi Han
authors.initials: YH
authors.lastname: Ng
authors.forename: Zhiping P
authors.initials: ZP
authors.lastname: Pang
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Südhof
authors.forename: Marius
authors.initials: M
authors.lastname: Wernig
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors