title: Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification.
abstract: Quantification of blood oxygen saturation on the basis of a measurement of its magnetic susceptibility demands knowledge of the difference in volume susceptibility between fully oxygenated and fully deoxygenated blood (Δχ(do) ). However, two very different values of Δχ(do) are currently in use. In this work we measured Δχ(do) as well as the susceptibility of oxygenated blood relative to water, Δχ(oxy) , by MR susceptometry in samples of freshly drawn human blood oxygenated to various levels, from 6 to 98% as determined by blood gas analysis. Regression analysis yielded 0.273 ± 0.006 and -0.008 ± 0.003 ppm (cgs) respectively, for Δχ(do) and Δχ(oxy) , in excellent agreement with previous work by Spees et al. (Magn Reson Med 2001;45:533-542).
authors.affiliation: Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
authors.forename: Varsha
authors.initials: V
authors.lastname: Jain
authors.forename: Osheiza
authors.initials: O
authors.lastname: Abdulmalik
authors.forename: Kathleen Joy
authors.initials: KJ
authors.lastname: Propert
authors.forename: Felix W
authors.initials: FW
authors.lastname: Wehrli
mesh_terms: D000465:Algorithms; D001790:Blood Physiological Phenomena; D001810:Blood Volume; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010092:Oximetry / Q000295:instrumentation*; D010100:Oxygen / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen