title: Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.
abstract: A multicomponent reaction of 3-aminopyrazol-5-ones with substituted salicylic aldehydes and acetylacetic ester leading to the formation of novel 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones was discovered. The elucidation of the reaction scope revealed that 5-aminopyrazoles, 3-amino-1,2,4-triazoles and 6-aminouracil could be used as the heterocyclic amine component. Selected heterocyclic products were found to possess notable antibacterial activities.
authors.affiliation: Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA.
authors.forename: Liliya V
authors.initials: LV
authors.lastname: Frolova
authors.forename: Indranil
authors.initials: I
authors.lastname: Malik
authors.forename: Pavel Y
authors.initials: PY
authors.lastname: Uglinskii
authors.forename: Snezna
authors.initials: S
authors.lastname: Rogelj
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
authors.forename: Igor V
authors.initials: IV
authors.lastname: Magedov