title: Synthesis, antibacterial, antielastase, antiurease and antioxidant activities of new 1,4-butylene bridged bis-1,2,4-triazole derivatives.
abstract: A new bis schiffbases, 3 a-b were synthesized compound 2 with various bis aldehydes. Compounds 3 a-b have been reduced with NaBH(4) to afford the corresponding bis amino triazole compounds 4 a-b. The obtained products 3 a-b and 4 a-b were identified by FTIR, (1)H-NMR, (13)C-NMR. A series of triazol derivatives were evaluated for their antibacterial, antioxidant, antiurease and antielastase activities. The results showed that the synthesized new bis-1,2,4-triazole derivatives had effective antioxidant, antiurease and antielastase activities.
authors.affiliation: Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Gumrukcuoglu
authors.forename: Bahar Bilgin
authors.initials: BB
authors.lastname: Sokmen
authors.forename: Serpil
authors.initials: S
authors.lastname: Ugras
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Ugras
authors.forename: Refiye
authors.initials: R
authors.lastname: Yanardag
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000475:Alkenes; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D014230:Triazoles; C558934:butylene; C045575:1,2,4-triazole; D010196:Pancreatic Elastase; D014510:Urease