title: Serum levels of IgG4 and soluble interleukin-2 receptor in patients with coronary artery disease.
abstract: BACKGROUND
  Immunoglobulin G4 (IgG4)-related immuno-inflammation has been suggested to play a role in the development of remodeling of arterial wall. We investigated the association between serum concentrations of IgG4 or soluble interleukin-2 receptor (sIL-2R) and coronary artery disease (CAD).
  
  
  METHODS
  Serum concentrations of IgG4 and sIL-2R were measured in 286 patients who underwent coronary angiography.
  
  
  RESULTS
  In patients with CAD, the medians of serum concentrations of IgG4 (39.3 mg/dl) and sIL-2R (388 U/ml) were significantly higher than corresponding values in patients without CAD (IgG4 27.0 mg/dl, sIL-2R 312 U/ml). In receiver-operating characteristic curve analysis, the area under the curve of sIL-2R and IgG4 for the presence of CAD was 0.634 and 0.632, respectively. Age- and gender-adjusted logistic regression analysis showed that both of the fourth quartile of sIL-2R concentrations (≥509 U/ml) and that of IgG4 concentrations (≥57.7 mg/dl) were found to be associated with CAD with an odds ratio of 2.82 and 4.08, respectively, compared with the corresponding lowest quartile.
  
  
  CONCLUSIONS
  Serum concentrations of IgG4 and sIL-2R were increased in patients with angiographically-proven CAD, suggesting that IgG4-related immuno-inflammation may also have a role in the development and/or progression of coronary artery atherosclerosis.
authors.affiliation: Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
authors.forename: Kan
authors.initials: K
authors.lastname: Saito
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Imai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
authors.forename: Takahide
authors.initials: T
authors.lastname: Kohro
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility
chemical_list: D007074:Immunoglobulin G; D015375:Receptors, Interleukin-2