title: Electrostatic self-assembly of multilayer copolymeric membranes on the surface of porous tantalum implants for sustained release of doxorubicin.
abstract: Many studies in recent years have focused on surface engineering of implant materials in order to improve their biocompatibility and other performance. Porous tantalum implants have increasingly been used in implant surgeries, due to their biocompatibility, physical stability, and good mechanical strength. In this study we functionalized the porous tantalum implant for sustained drug delivery capability via electrostatic self-assembly of polyelectrolytes of hyaluronic acid, methylated collagen, and terpolymer on the surface of a porous tantalum implant. The anticancer drug doxorubicin was encapsulated into the multilayer copolymer membranes on the porous tantalum implants. Results showed the sustained released of doxorubicin from the functionalized porous tantalum implants for up to 1 month. The drug release solutions in 1 month all had inhibitory effects on the proliferation of chondrosarcoma cell line SW1353. These results suggest that this functionalized implant could be used in reconstructive surgery for the treatment of bone tumor as a local, sustained drug delivery system.
authors.affiliation: Orthopaedic Research institute/ Department of Orthopaedic Surgery, First Affiliated Hospital and Department of Pharmacy, Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Guo
authors.forename: Muwan
authors.initials: M
authors.lastname: Chen
authors.forename: Wenzhou
authors.initials: W
authors.lastname: Feng
authors.forename: Jiabi
authors.initials: J
authors.lastname: Liang
authors.forename: Huibin
authors.initials: H
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Tian
authors.forename: Hui
authors.initials: H
authors.lastname: Chao
authors.forename: Xuenong
authors.initials: X
authors.lastname: Zou
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002813:Chondrosarcoma / Q000188:drug therapy / Q000378:metabolism; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D004343:Drug Implants / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D055672:Static Electricity; D013499:Surface Properties; D013635:Tantalum / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004343:Drug Implants; D008567:Membranes, Artificial; D011108:Polymers; D013635:Tantalum; D004317:Doxorubicin; D006820:Hyaluronic Acid