title: Novel poly(ADP-ribose) polymerase-1 inhibitors.
abstract: Synthesis and activity of a series of 3-aroyl-derived analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are disclosed.
authors.affiliation: Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380 4245, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Dunn
authors.forename: Jean
authors.initials: J
authors.lastname: Husten
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ator
authors.forename: Sankar
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004249:DNA Damage; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D009243:NAD / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D016716:PC12 Cells; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D009243:NAD; C499320:PARP1 protein, human; C499322:Parp1 protein, rat; D000071137:Poly (ADP-Ribose) Polymerase-1