title: Lipomatous hemangiopericytoma of the stomach: a case report and a review of literature.
abstract: Lipomatous hemangiopericytomas (LHPCs) are rare soft-tissue tumors that are histologically characterized by hemangiopericytomatous vasculature and the presence of mature adipocytes. We present the clinicopathological features of a case of gastric LHPC in a 56-year-old female, along with a literature review. Endoscopy and endoscopic ultrasound showed a submucosal tumor 0.8 cm across in the greatest dimension in the lesser curvature side of the gastric antrum. Grossly, the well-defined mass had a solid and tan-white cut surface admixed with myxoid regions and yellowish areas. Histological examination revealed a submucosal well-circumscribed lesion composed of cellular nodules with the classic appearance of an hemangiopericytoma admixed with clusters and lobules of mature adipocytes. The ill-defined tumor cells had weakly eosinophilic cytoplasm and contained spindled nuclei with occasional small nucleoli. Nuclei atypia and mitoses were absent, and no cellular atypia, necrosis or vascular invasion was observed. Immunohistochemistry showed that the tumor cells were diffusely positive for CD34, CD99, and vimentin and were focally reactive for bcl-2. This is the first known report of an LHPC in the stomach. The patient was followed for 12 mo without any evidence of metastasis or recurrence.
authors.affiliation: Department of Pathology, The General Hospital, Jinan Military Command, Jinan 250031, Shandong Province, China. jinghong.biao@hotmail.com
authors.forename: Hong-Biao
authors.initials: HB
authors.lastname: Jing
authors.forename: Qing-Da
authors.initials: QD
authors.lastname: Meng
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Tai
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006393:Hemangiopericytoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008067:Lipoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor