title: Protein intake and bone health.
abstract: Adequate nutrition plays an important role in the development and maintenance of bone structures resistant to usual mechanical stresses. In addition to calcium in the presence of an adequate supply of vitamin D, dietary proteins represent key nutrients for bone health and thereby function in the prevention of osteoporosis. Several studies point to a positive effect of high protein intake on bone mineral density or content. This fact is associated with a significant reduction in hip fracture incidence, as recorded in a large prospective study carried out in a homogeneous cohort of postmenopausal women. Low protein intake (< 0.8 g/kg body weight/day) is often observed in patients with hip fractures and an intervention study indicates that following orthopedic management, protein supplementation attenuates post-fracture bone loss, tends to increase muscle strength, and reduces medical complications and rehabilitation hospital stay. There is no evidence that high protein intake per se would be detrimental for bone mass and strength. Nevertheless, it appears reasonable to avoid very high protein diets (i. e. more than 2.0 g/kg body weight/day) when associated with low calcium intake (i. e. less than 600 mg/day). In the elderly, taking into account the attenuated anabolic response to dietary protein with ageing, there is concern that the current dietary protein recommended allowance (RDA), as set at 0.8 g/kg body weight/day, might be too low for the primary and secondary prevention of fragility fractures.
authors.affiliation: Division of Bone Diseases, University Hospitals and Faculty of Medicine, Geneva, Switzerland. jean-philippe.bonjour@unige.ch
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bonjour
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000856:Anorexia Nervosa / Q000178:diet therapy / Q000503:physiopathology; D001862:Bone Resorption / Q000209:etiology / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D019587:Dietary Supplements; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control; D016330:Frail Elderly; D006293:Health Promotion; D006801:Humans; D008297:Male; D009043:Motor Activity; D018673:Nutrition Policy; D010012:Osteogenesis; D015663:Osteoporosis, Postmenopausal / Q000178:diet therapy / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D004044:Dietary Proteins