title: Three-dimensional multimodal image non-rigid registration and fusion in a High Intensity Focused Ultrasound system.
abstract: High Intensity Focused Ultrasound (HIFU) has been successfully applied in tumor therapy. For a successful HIFU therapy, it is crucial to localize the tumor region accurately. In this paper, we present a semi-automatic non-rigid registration method for implementing image guided surgery navigation and localization by matching pre-operative CT/MR images and intra-operative ultrasound images. The global motion of the target is modeled by an affine transformation, while the local deformation of the target is described by Free-Form Deformation (FFD) based on B-splines. The results of our experiments on simulated and real data show that the non-rigid registration method based on HPV interpolation (partial volume based on the Hanning windowed sinc function) is effective at restraining local extrema and improves the accuracy of registration results. A preliminary clinical validation of the use of the non-rigid registration method in image guided localization of a HIFU system is also reported.
authors.affiliation: College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, China. luxsyyl@gmail.com
authors.forename: Xuesong
authors.initials: X
authors.lastname: Lu
authors.forename: Shiteng
authors.initials: S
authors.lastname: Suo
authors.forename: Haihua
authors.initials: H
authors.lastname: Liu
authors.forename: Su
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D059708:Ultrasonic Surgical Procedures / Q000295:instrumentation*