title: Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer.
abstract: BACKGROUND
  EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown.
  
  
  OBJECTIVE
  To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary-care academic medical center.
  
  
  METHODS
  This study involved all patients in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 patients (66.2% men) were enrolled.
  
  
  METHODS
  EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR.
  
  
  METHODS
  Resectability, curability, and recurrence.
  
  
  RESULTS
  Complete cure was achieved for 162 lesions (68.6%). Of the remaining 74 cases (31.4%), 69 (29.2%) were incompletely cured, and the other 5 (2.1%) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and submucosal carcinoma were independently associated with incomplete resection, whereas depressed tumor type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8%) during the median follow-up period of 39.4 months (range 12.4-123.1 months).
  
  
  CONCLUSIONS
  Single-center, retrospective study.
  
  
  CONCLUSIONS
  Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.
authors.affiliation: Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea.
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Cheon
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kwon
authors.forename: Jae Kook
authors.initials: JK
authors.lastname: Shin
authors.forename: Soung Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Bok
authors.forename: Jin Ha
authors.initials: JH
authors.lastname: Lee
authors.forename: Chang Mo
authors.initials: CM
authors.lastname: Moon
authors.forename: Sung Pil
authors.initials: SP
authors.lastname: Hong
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Hoguen
authors.initials: H
authors.lastname: Kim
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D004210:Dissection / Q000379:methods*; D042241:Early Diagnosis; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome