title: Isolation and characterization of enterocin W, a novel two-peptide lantibiotic produced by Enterococcus faecalis NKR-4-1.
abstract: Enterococcus faecalis NKR-4-1 isolated from pla-ra produces a novel two-peptide lantibiotic, termed enterocin W, comprising Wα and Wβ. The structure of enterocin W exhibited similarity with that of plantaricin W. The two peptides acted synergistically, and their order of binding to the cell membrane was important for their inhibitory activity.
authors.affiliation: Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Hakozaki, Higashi-ku, Fukuoka, Japan.
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Sawa
authors.forename: Pongtep
authors.initials: P
authors.lastname: Wilaipun
authors.forename: Seisuke
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Zendo
authors.forename: Vichien
authors.initials: V
authors.lastname: Leelawatcharamas
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Sonomoto
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D001483:Base Sequence; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004357:Drug Synergism; D013293:Enterococcus faecalis / Q000378:metabolism*; D005798:Genes, Bacterial / Q000235:genetics; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D001952:Bridged-Ring Compounds; D004269:DNA, Bacterial; D004151:Dipeptides; C012306:enterocin