title: Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex.
abstract: A dinuclear Cu(II) complex, [Cu(2)(μ-IDA)(phen)(3)(NO(3))]NO(3)·4H(2)O (phen = 1,10-phenanthroline, H(2)IDA = iminodiacetic acid), was found to potently and selectively inhibit T-cell protein tyrosine phosphatase, and lead to the anti-proliferation and apoptosis of C6 glioma cells.
authors.affiliation: Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, P.R. China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Yuan
authors.forename: Miaoli
authors.initials: M
authors.lastname: Zhu
authors.forename: Qingming
authors.initials: Q
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Lu
authors.forename: Shu
authors.initials: S
authors.lastname: Xing
authors.forename: Xueqi
authors.initials: X
authors.lastname: Fu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Li
authors.forename: Zhuoyu
authors.initials: Z
authors.lastname: Li
authors.forename: Ruiting
authors.initials: R
authors.lastname: Zhu
authors.forename: Ling
authors.initials: L
authors.lastname: Ma
authors.forename: Liqing
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D003300:Copper; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2