title: Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment.
abstract: The preferential dopamine D(3)-agonist pramipexole (4.25±0.38 mg/day) or placebo were added for up to 12 weeks to ongoing antipsychotic treatment for 24 adult patients with DSM-IV schizophrenia or schizoaffective disorder. Pramipexole was generally well-tolerated (82% trial-completion), and yielded greater decreases in PANSS-total scores (drug/placebo=2.1; p=0.04), with similar decreases in PANSS positive and negative scores and 6.7-fold greater reduction of serum prolactin concentrations compared to placebo. There were no differences in ratings of mood, cognition or extrapyramidal symptoms, all of which were low at intake.
authors.affiliation: Department of Psychiatry, St. Vincent's Hospital Westchester, Harrison, NY 10528, USA. jkelleher@svwsjmc.org
authors.forename: James P
authors.initials: JP
authors.lastname: Kelleher
authors.forename: Franca
authors.initials: F
authors.lastname: Centorrino
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Huxley
authors.forename: John A
authors.initials: JA
authors.lastname: Bates
authors.forename: Jennifer Kidwell
authors.initials: JK
authors.lastname: Drake
authors.forename: Samy
authors.initials: S
authors.lastname: Egli
authors.forename: Ross J
authors.initials: RJ
authors.lastname: Baldessarini
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D052160:Benzothiazoles / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D010865:Pilot Projects; D000077487:Pramipexole; D011388:Prolactin / Q000097:blood; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D014150:Antipsychotic Agents; D052160:Benzothiazoles; D000077487:Pramipexole; D011388:Prolactin