title: Evaluation of the correlation between genetic damage and occupational chromate exposure through BNMN frequencies.
abstract: OBJECTIVE
  To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage.
  
  
  METHODS
  There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted.
  
  
  RESULTS
  The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models.
  
  
  CONCLUSIONS
  The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.
authors.affiliation: School of Public Health, Department of Occupational and Environmental Health Sciences, Peking University, Beijing, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Xiaohua
authors.forename: Song
authors.initials: S
authors.lastname: Yanshuang
authors.forename: Wang
authors.initials: W
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Yuhui
authors.forename: Zhang
authors.initials: Z
authors.lastname: Ji
authors.forename: Ma
authors.initials: M
authors.lastname: Yanhui
authors.forename: Wang
authors.initials: W
authors.lastname: Yun
authors.forename: Ma
authors.initials: M
authors.lastname: Wenjun
authors.forename: Yan
authors.initials: Y
authors.lastname: Lei
authors.forename: Jia
authors.initials: J
authors.lastname: Guang
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis; D002840:Chromates / Q000633:toxicity*; D002857:Chromium / Q000097:blood / Q000652:urine; D004249:DNA Damage; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D008875:Middle Aged; D016273:Occupational Exposure / Q000706:statistics & numerical data*
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D015415:Biomarkers; D002840:Chromates; D002857:Chromium