title: Correlation of low SLC22A18 expression with poor prognosis in patients with glioma.
abstract: We investigated the expression of the putative tumor suppressor SLC22A18 to evaluate it as a prognostic marker in glioma patients. Immunohistochemical and Western blot analyses of clinical tissue samples obtained from 120 patients with glioma were performed. Low expression of SLC22A18 was observed in 71.7% of patients. Loss of SLC22A18 expression in glioma was significantly related to pathological grade (p = 0.003). High pathological grade (World Health Organization III-IV) was correlated with negative (low or absent) expression of SLC22A18, which was correlated with a significantly shorter overall patient survival than in those with positive (high) expression (p = 0.007). Multivariate Cox regression analysis indicated that SLC22A18 expression level is an independent survival prognostic factor for patients with glioma (p = 0.011). Western blotting analysis confirmed decreased expression of SLC22A18 in glioma tissues compared with adjacent brain tissues. This study suggests that SLC22A18 functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease.
authors.affiliation: Department of Neurosurgery, No 3 People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, 280 Mo He Road, Bao Shan District, Shanghai 201900, China. shenghuachu@126.com
authors.forename: Sheng-Hua
authors.initials: SH
authors.lastname: Chu
authors.forename: Yan-Bin
authors.initials: YB
authors.lastname: Ma
authors.forename: Dong-Fu
authors.initials: DF
authors.lastname: Feng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhi-An
authors.initials: ZA
authors.lastname: Zhu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Li
authors.forename: Pu-Cha
authors.initials: PC
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000172:deficiency* / Q000502:physiology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D015536:Down-Regulation / Q000502:physiology*; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D027701:Organic Cation Transport Proteins / Q000096:biosynthesis / Q000172:deficiency* / Q000502:physiology; D011379:Prognosis; D015996:Survival Rate; D025521:Tumor Suppressor Proteins / Q000172:deficiency; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D027701:Organic Cation Transport Proteins; C111653:SLC22A18 protein, human; D025521:Tumor Suppressor Proteins