title: Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
abstract: Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported.
authors.affiliation: Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Esposito
authors.forename: Caterina
authors.initials: C
authors.lastname: Scuderi
authors.forename: Marta
authors.initials: M
authors.lastname: Valenza
authors.forename: Giuseppina Ines
authors.initials: GI
authors.lastname: Togna
authors.forename: Valentina
authors.initials: V
authors.lastname: Latina
authors.forename: Daniele
authors.initials: D
authors.lastname: De Filippis
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Cipriano
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Carratù
authors.forename: Teresa
authors.initials: T
authors.lastname: Iuvone
authors.forename: Luca
authors.initials: L
authors.lastname: Steardo
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002185:Cannabidiol / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D008297:Male; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D047495:PPAR gamma; D002185:Cannabidiol; D009569:Nitric Oxide