title: An open-ended plea for the development of a global database of HIV vaccine responses.
abstract: OBJECTIVE
  The purpose of this review is to describe a critical need of the HIV research community for a globally accessible database of HIV vaccine responses that stores data from multiple assay platforms in the form of lists of correlates of immune protection and vaccine efficacy. This is not a detailed review but a first step toward developing a dialogue among investigators and funding organizations to build upon existing resources to efficiently develop a HIV vaccine response and correlates database. We also discuss examples of databases that complement our needs and could be integrated into our proposed database requirements.
  
  
  RESULTS
  Several vaccine-related databases that store information at the study level currently exist, however, at the present time, a correlates of immune protection database does not exist.
  
  
  CONCLUSIONS
  Here, we discuss the scientific climate surrounding HIV vaccine development with the evolution of systems biology approaches, the problems at hand for analyzing and harmonizing datasets generated from preclinical and clinical studies, and the curation and accessibility of useful information to model outcomes. We also compare key database requirements of a few existing globally accessible databases and provide several illustrative correlate database submission and utilization examples.
authors.affiliation: Vaccine and Gene Therapy Institute of Florida, Port Saint Lucie, Florida, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Wilkinson
authors.forename: Abdelali
authors.initials: A
authors.lastname: Filali-Mouhim
authors.forename: Shuzhao
authors.initials: S
authors.lastname: Li
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Ahlers
authors.forename: John
authors.initials: J
authors.lastname: Schatzle
authors.forename: Bali
authors.initials: B
authors.lastname: Pulendran
authors.forename: Rafick-Pierre
authors.initials: RP
authors.lastname: Sekaly
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cameron
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D015415:Biomarkers; D019992:Databases as Topic; D016208:Databases, Factual; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans
chemical_list: D016915:AIDS Vaccines; D015415:Biomarkers