title: A single nucleotide polymorphism in EXO1 gene is associated with cervical cancer susceptibility in Chinese patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of Exonuclease1 (EXO1) genetic polymorphism and the development of cervical carcinoma.
  
  
  METHODS
  This study was conducted with 126 patients diagnosed with cervical cancer and 278 people with no cancer history. The polymerase chain reaction-based restriction fragment length polymorphism was used to evaluate the K589E and C908G gene polymorphisms. Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk for cervical cancer.
  
  
  RESULTS
  This is the first study on the role of EXO1 K589E (rs1047840) and EXO1 C908G (rs10802996) polymorphisms in cervical cancer in a Chinese population. Our results indicated that the EXO1 K589G polymorphism were significantly associated with the risk for cervical cancer. Compared with the G allele EXO1 K589E, the A allele increased the risk for cervical cancer (adjusted odds ratio, 1.67; 95% confidence interval, 1.13-2.45). By contrast, we have not found a significant association between the EXO1 C908G polymorphism and cervical cancer risk (P = 0.791).
  
  
  CONCLUSIONS
  These findings indicate that the SNPs of EXO1 K589E may contribute to cervical cancer carcinogenesis in Chinese populations. A larger population study will need to be carried out to further validate the potential association of EXO1 genetic polymorphism and cervical carcinoma.
authors.affiliation: Guangdong Women and Children's Hospital, Guangzhou, Guangdong, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Luo
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Hong
authors.forename: Xing-Dong
authors.initials: XD
authors.lastname: Xiong
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Zeng
authors.forename: Chi Eung Danforn
authors.initials: CE
authors.lastname: Lim
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality; D000328:Adult; D044466:Asian People; D018196:Carcinoma, Adenosquamous / Q000235:genetics / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000401:mortality; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D045643:DNA Repair Enzymes / Q000235:genetics*; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: D017931:DNA Primers; C114331:EXO1 protein, human; D005090:Exodeoxyribonucleases; D045643:DNA Repair Enzymes