title: Molecular targets for the treatment of juvenile myelomonocytic leukemia.
abstract: Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Liu
authors.forename: Himalee
authors.initials: H
authors.lastname: Sabnis
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Bunting
authors.forename: Cheng-Kui
authors.initials: CK
authors.lastname: Qu