title: Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV.
abstract: Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.
authors.affiliation: HIV & Sexual Health Department, Chelsea and Westminster Hospital, London, United Kingdom. gurmit.jagjitsingh@chelwest.nhs.uk
authors.forename: Gurmit K
authors.initials: GK
authors.lastname: Jagjit Singh
authors.forename: Samreen
authors.initials: S
authors.lastname: Ijaz
authors.forename: Neesha
authors.initials: N
authors.lastname: Rockwood
authors.forename: Simon P
authors.initials: SP
authors.lastname: Farnworth
authors.forename: Emma
authors.initials: E
authors.lastname: Devitt
authors.forename: Mark
authors.initials: M
authors.lastname: Atkins
authors.forename: Richard
authors.initials: R
authors.lastname: Tedder
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D054459:Elasticity Imaging Techniques; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000821:virology*; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000097:blood / Q000188:drug therapy / Q000821:virology*; D006521:Hepatitis, Chronic / Q000097:blood / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D006508:Hepatitis Antibodies; D016898:Interferon-alpha; D011092:Polyethylene Glycols