title: Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant.
abstract: This case report describes severe hyperinsulinism in a term newborn infant without typical perinatal risk factors for transient hyperinsulinism. The mother had received bupropion, an antidepressant and aid to smoking cessation, throughout pregnancy. The infant presented with profound hypoglycemia and seizures on the 3rd day of life. Laboratory investigation confirmed hyperinsulinism. Stable euglycemia could be achieved only after starting diazoxide. The infant was weaned from diazoxide by 10 weeks of age without recurrence of hypoglycemia, signifying the transient nature of hyperinsulinism. This is the first reported case of a potential association between maternal bupropion use during pregnancy and neonatal hyperinsulinism, and highlights the importance of close monitoring of similar infants.
authors.affiliation: Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis 55455, MN, USA.
authors.forename: Tate
authors.initials: T
authors.lastname: Gisslen
authors.forename: Brandon
authors.initials: B
authors.lastname: Nathan
authors.forename: Theodore
authors.initials: T
authors.lastname: Thompson
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Rao
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D016642:Bupropion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000139:chemically induced*; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D016540:Smoking Cessation / Q000379:methods
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion