title: An expedient synthesis of honokiol and its analogues as potential neuropreventive agents.
abstract: An efficient synthesis of honokiol with Suzuki-Miyaura cross coupling obtained an overall yield of 45%. The proposed approach successfully synthesized several structurally similar alkyl, alkenyl and alkynyl analogues, seven of which showed potential neuropreventive activity against MPP(+)-induced and CHP/TBHP oxidative stress induced neuroblastoma cell death.
authors.affiliation: Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Subhankar
authors.initials: S
authors.lastname: Tripathi
authors.forename: Ming-Huan
authors.initials: MH
authors.lastname: Chan
authors.forename: Chinpiao
authors.initials: C
authors.lastname: Chen
mesh_terms: D001713:Biphenyl Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D016923:Cell Death; D045744:Cell Line, Tumor; D002470:Cell Survival; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D017705:Lignans / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D009447:Neuroblastoma / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000188:drug therapy; D017382:Reactive Oxygen Species; D013997:Time Factors; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D001713:Biphenyl Compounds; D017705:Lignans; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols