title: Naftidrofuryl for dementia.
abstract: BACKGROUND
  Dementia is a brain disorder characterized by the permanent loss of higher cognitive functions. A number of vasodilatory drug treatments are prescribed for dementia. Naftidrofuryl is one such medicine which is reported to improve clinical symptoms significantly. The efficacy and possible adverse events of naftidrofuryl need to be reviewed systematically and assessed critically to inform clinical practice and guide the continued search for new treatment regimens.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of naftidrofuryl in the treatment of dementia.
  
  
  METHODS
  We searched ALOIS: the Cochrane Dementia and Cognitive Improvement Group's Specialized Register on 11 January 2011 using the terms: naftidrofuryl. ALOIS contains records of clinical trials from major healthcare databases (MEDLINE, EMBASE, PsycINFO, LILACS and CINAHL), trial registries (such as ClinicalTrials.gov) and grey literature sources.
  
  
  METHODS
  Randomised placebo-controlled trials in which patients with dementia were treated with naftidrofuryl were considered eligible for inclusion.
  
  
  METHODS
  Two review authors independently selected trials for inclusion, assessed trial quality, and extracted data using data extraction forms. The domains assessed for risk of bias were sequence generation, allocation concealment, blinding, incomplete outcome data, and selective outcome reporting. We used odds ratios (OR) for reporting dichotomous data, and mean differences (MD) and standardized mean differences (SMD) for continuous data. We assessed statistical heterogeneity using the I(2) statistic.
  
  
  RESULTS
  We identified nine randomised controlled trials involving 847 patients with Alzheimer's disease, vascular dementia, mixed dementia, senile dementia and unspecified dementia. The beneficial effects were found on functional performance and behaviour (-1.04 standardized points, 95% CI -1.73 to -0.35, P = 0.003) with a high-level heterogeneity (I(2) = 54%), and mood (-0.80 standardized points, 95% CI -1.26 to -0.34, P=0.0006) for patients with dementia, as well as on cognitive function (-0.36 standardized points, 95% CI -0.71 to -0.02, P=0.04). However, this was not confirmed by clinical global measures. Naftidrofuryl was found to be well-tolerated by patients with dementia.
  
  
  CONCLUSIONS
  Oral administration of naftidrofuryl is well-tolerated by patients with dementia.The low-quality evidence shows that, by use of naftidrofuryl, people with dementia may benefit on performance, behaviour, cognition, and mood. However, the benefit on global impression is inconsistent and unconvincing.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Third Section of Ren Min Nan Road, Chengdu, Sichuan, China, 610041.
authors.forename: Donghao
authors.initials: D
authors.lastname: Lu
authors.forename: Huan
authors.initials: H
authors.lastname: Song
authors.forename: Zilong
authors.initials: Z
authors.lastname: Hao
authors.forename: Taixiang
authors.initials: T
authors.lastname: Wu
authors.forename: Jenny
authors.initials: J
authors.lastname: McCleery
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009257:Nafronyl / Q000009:adverse effects / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D018697:Nootropic Agents; D011619:Psychotropic Drugs; D009257:Nafronyl