title: In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes.
abstract: We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.
authors.affiliation: Université Lille Nord de France, Université Lille1, UCCS-UMR CNRS 8181, 59652 Villeneuve d'Ascq Cedex, France.
authors.forename: Faustine
authors.initials: F
authors.lastname: Dubar
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bohic
authors.forename: Christian
authors.initials: C
authors.lastname: Slomianny
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Morin
authors.forename: Patrick
authors.initials: P
authors.lastname: Thomas
authors.forename: Hadidjatou
authors.initials: H
authors.lastname: Kalamou
authors.forename: Yann
authors.initials: Y
authors.lastname: Guérardel
authors.forename: Peter
authors.initials: P
authors.lastname: Cloetens
authors.forename: Jamal
authors.initials: J
authors.lastname: Khalife
authors.forename: Christophe
authors.initials: C
authors.lastname: Biot
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000962:Antimalarials / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D004912:Erythrocytes / Q000378:metabolism*; D005296:Ferrous Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013058:Mass Spectrometry; D000075163:Metallocenes; D046529:Microscopy, Electron, Transmission; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000648:ultrastructure; D013052:Spectrometry, X-Ray Emission
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D005296:Ferrous Compounds; D000075163:Metallocenes; C479230:ferroquine