title: Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.
abstract: Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Wong
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Chu-Huang
authors.initials: CH
authors.lastname: Chen
authors.forename: Shiow-Chwen
authors.initials: SC
authors.lastname: Tsai
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification; D019770:Lauraceae / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D015394:Molecular Structure; D016328:NF-kappa B / Q000187:drug effects; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002243:Carbolines; D007529:Isoflavones; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012717:Sesquiterpenes; C083295:prunetin; D052247:Nitric Oxide Synthase Type II