title: The impact of gold nanoparticles on hTERT gene expression leading to termination of malignant tumor.
abstract: Cancer nanotechnology is a fascinating field with broad applications in the fight against cancer which includes molecular imaging, molecular diagnosis, and targeted therapy. One of the emerging field of nanotechnology is applying of cancer therapy to specifically target therapeutic agents to tumor cells while sparing healthy tissues from harm. Among the many nanomaterials being developed in nanomedicine application, gold nano particles have found promising application in treatment of cancer because of its unique properties. In this study, we have proposed a hypothetical approach to terminate solid tumors using anticancerous nanotherapeutic via gold nano particles. These gold nano particles target the promoter region of hTERT by stabilizing the G-quadruplex structure and block the transcription of 5'-UTR region of hTERT gene.
authors.forename: C George Priya
authors.initials: CG
authors.lastname: Doss
authors.forename: C
authors.initials: C
authors.lastname: Debajyoti
authors.forename: S
authors.initials: S
authors.lastname: Debottam
mesh_terms: D015316:Genetic Therapy / Q000379:methods; D006046:Gold / Q000008:administration & dosage*; D006801:Humans; D008957:Models, Genetic; D053758:Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy*; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism; D035321:Telomeric Repeat Binding Protein 1 / Q000235:genetics
chemical_list: D035321:Telomeric Repeat Binding Protein 1; D006046:Gold; C509186:TERT protein, human; D019098:Telomerase