title: Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  The relationship between major adverse cardiac events (MACE) and serum polyunsaturated fatty acid (PUFA) parameters has not been well documented in patients who have undergone percutaneous coronary intervention (PCI). The aim of the present study was to investigate this relationship.
  
  
  RESULTS
  A total of 284 consecutive patients who underwent elective PCI were enrolled and stratified according to median serum levels of n-6 PUFAs (arachidonic acid [AA]), n-3 PUFAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), and serum EPA/AA and DHA/AA ratios. The relationship between these PUFA parameters and the incidence of MACE including cardiac death, acute coronary syndrome, PCI for de novo lesions, and coronary artery bypass grafting, was analyzed. Multivariate analysis showed that among the PUFA parameters, only a high serum EPA/AA ratio was significantly associated with a low incidence of MACE in all the models tested (model A, without adjusted variables: hazard ratio [HR], 0.52; 95% confidence interval [CI]: 0.27-0.99, P = 0.048; model B, adjusted for age and diabetes: HR, 0.51; 95%CI: 0.26-0.98, P = 0.043; model C, adjusted for age, sex, diabetes, hypertension, smoking, and low-density lipoprotein cholesterol: HR, 0.49; 95%CI: 0.25-0.94, P = 0.033).
  
  
  CONCLUSIONS
  The incidence of MACE in patients who have undergone PCI is significantly associated with serum EPA/AA ratio.
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan. dotake310@yahoo.co.jp
authors.forename: Takenori
authors.initials: T
authors.lastname: Domei
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yokoi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Kuramitsu
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Soga
authors.forename: Takeshi
authors.initials: T
authors.lastname: Arita
authors.forename: Kenji
authors.initials: K
authors.lastname: Ando
authors.forename: Shinichi
authors.initials: S
authors.lastname: Shirai
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kondo
authors.forename: Koyu
authors.initials: K
authors.lastname: Sakai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Goya
authors.forename: Masashi
authors.initials: M
authors.lastname: Iwabuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ueeda
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Nobuyoshi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000453:epidemiology* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000706:statistics & numerical data*; D016718:Arachidonic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D016718:Arachidonic Acid