title: Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats.
abstract: OBJECTIVE
  To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats.
  
  
  METHODS
  Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique.
  
  
  RESULTS
  The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003).
  
  
  CONCLUSIONS
  These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.
authors.affiliation: Laboratory of Morphology and Structural Biology, Research and Technology Institute, Tiradentes University, Sergipe, Brazil. sonia.sol@ibest.com.br
authors.forename: Sônia Oliveira
authors.initials: SO
authors.lastname: Lima
authors.forename: Luciano da Costa
authors.initials: Lda C
authors.lastname: Viana
authors.forename: Fábio Rafael Teixeira de
authors.initials: FR
authors.lastname: Santana
authors.forename: Ségio
authors.initials: S
authors.lastname: Zucoloto
authors.forename: Ricardo Luiz de
authors.initials: RL
authors.lastname: Albuquerque Junior
authors.forename: Margarete Zanardo
authors.initials: MZ
authors.lastname: Gomes
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D006498:Hepatectomy; D031331:Hyptis / Q000737:chemistry*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen