title: FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma.
abstract: Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide association studies have identified 14 independently replicated common single nucleotide polymorphisms that influence breast cancer risk. To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111). These data provide evidence that genetic variation in FGFR2 influences radiation-induced breast cancer risk.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Rd., Sutton, Surrey, United Kingdom.
authors.forename: Yussanne P
authors.initials: YP
authors.lastname: Ma
authors.forename: Flora E
authors.initials: FE
authors.lastname: van Leeuwen
authors.forename: Rosie
authors.initials: R
authors.lastname: Cooke
authors.forename: Annegien
authors.initials: A
authors.lastname: Broeks
authors.forename: Victor
authors.initials: V
authors.lastname: Enciso-Mora
authors.forename: Bianca
authors.initials: B
authors.lastname: Olver
authors.forename: Amy
authors.initials: A
authors.lastname: Lloyd
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Nicola S
authors.initials: NS
authors.lastname: Russell
authors.forename: Cecile
authors.initials: C
authors.lastname: Janus
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Swerdlow
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000150:complications / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006689:Hodgkin Disease / Q000150:complications / Q000235:genetics / Q000532:radiotherapy*; D006801:Humans; D042361:Mammary Glands, Human / Q000528:radiation effects*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics*; D012306:Risk; D006113:United Kingdom / Q000453:epidemiology
chemical_list: C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2