title: Size controlled synthesis of biocompatible gold nanoparticles and their activity in the oxidation of NADH.
abstract: Size and shape controlled synthesis remains a major bottleneck in the research on nanoparticles even after the development of different methods for their preparation. By tuning the size and shape of a nanoparticle, the intrinsic properties of the nanoparticle can be controlled leading tremendous potential applications in different fields of science and technology. We describe a facile route for the one pot synthesis of gold nanoparticles in water using monosodium glutamate as the reducing and stabilizing agent in the absence of seed particles. The particle diameter can be easily controlled by varying the pH of the reaction medium. Nanoparticles were characterized using scanning electron microscopy, UV-vis absorption spectroscopy, cyclic voltammetry, and dynamic light scattering. Zeta potential measurements were made to compare the stability of the different nanoparticles. The results suggest that lower pH favours a nucleation rate giving rise to smaller particles and higher pH favours a growth rate leading to the formation of larger particles. The synthesized nanoparticles are found to be stable and biocompatible. The nanoparticles synthesized at high pH exhibited a good electrocatalytic activity towards oxidation of nicotinamide adenine dinucleotide (NADH).
authors.affiliation: School of Nano Science and Technology, National Institute of Technology, Calicut, Kerala, India.
authors.forename: Parvathy R
authors.initials: PR
authors.lastname: Chandran
authors.forename: M
authors.initials: M
authors.lastname: Naseer
authors.forename: N
authors.initials: N
authors.lastname: Udupa
authors.forename: N
authors.initials: N
authors.lastname: Sandhyarani
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival; D006046:Gold / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D009243:NAD / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010084:Oxidation-Reduction; D010316:Particle Size; D012970:Sodium Glutamate / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D009243:NAD; D006046:Gold; D012970:Sodium Glutamate