title: Serotonergic action on dorsal striatal function.
abstract: Serotonin (5-HT) is a monoamine neurotransmitter released throughout the brain. The serotonergic system is implicated in a host of neuropsychiatric disorders including, but not limited to, Parkinson's disease and L-DOPA-induced dyskinesia. These are pathological and drug-induced states that center on dysfunction of the striatum, a basal ganglia structure necessary for voluntary movement control and action learning. 5-HT is released by dorsal raphe nucleus neurons into the dorsal striatum where it acts upon diverse 5-HT receptors that are expressed on various pre- and postsynaptic components. Here, we review the literature on serotonergic effects on dorsal striatal function and discuss possible roles for the striatal serotonergic system in physiological and parkinsonian states.
authors.affiliation: Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, MD 20852-9411, USA.
authors.forename: Brian N
authors.initials: BN
authors.lastname: Mathur
authors.forename: David M
authors.initials: DM
authors.lastname: Lovinger
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000378:metabolism / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents; D011985:Receptors, Serotonin; D012701:Serotonin