title: MicroRNA therapeutics in cardiovascular medicine.
abstract: Cardiovascular diseases are the most common causes of human morbidity and mortality despite significant therapeutic improvements by surgical, interventional and pharmacological approaches in the last decade. MicroRNAs (miRNAs) are important and powerful mediators in a wide range of diseases and thus emerged as interesting new drug targets. An array of animal and even human miRNA-based therapeutic studies has been performed, which validate miRNAs as being successfully targetable to treat a wide range of diseases. Here, the current knowledge about miRNAs therapeutics in cardiovascular diseases on their way to clinical use are reviewed and discussed.
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany. thum.thomas@mh-hannover.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000628:therapy; D050197:Atherosclerosis / Q000628:therapy; D002318:Cardiovascular Diseases / Q000628:therapy*; D004337:Drug Carriers / Q000737:chemistry / Q000191:economics / Q000493:pharmacokinetics; D006801:Humans; D035683:MicroRNAs / Q000627:therapeutic use*; D018919:Neovascularization, Physiologic; D009841:Oligonucleotides / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers; D035683:MicroRNAs; D009841:Oligonucleotides