title: Longitudinally guided level sets for consistent tissue segmentation of neonates.
abstract: Quantification of brain development as well as disease-induced pathologies in neonates often requires precise delineation of white matter, grey matter and cerebrospinal fluid. Unlike adults, tissue segmentation in neonates is significantly more challenging due to the inherently lower tissue contrast. Most existing methods take a voxel-based approach and are limited to working with images from a single time-point, even though longitudinal scans are available. We take a different approach by taking advantage of the fact that the pattern of the major sulci and gyri are already present in the neonates and generally preserved but fine-tuned during brain development. That is, the segmentation of late-time-point image can be used to guide the segmentation of neonatal image. Accordingly, we propose a novel longitudinally guided level-sets method for consistent neonatal image segmentation by combining local intensity information, atlas spatial prior, cortical thickness constraint, and longitudinal information into a variational framework. The minimization of the proposed energy functional is strictly derived from a variational principle. Validation performed on both simulated and in vivo neonatal brain images shows promising results.
authors.affiliation: IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Pew-Thian
authors.initials: PT
authors.lastname: Yap
authors.forename: Weili
authors.initials: W
authors.lastname: Lin
authors.forename: John H
authors.initials: JH
authors.lastname: Gilmore
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D001931:Brain Mapping; D003198:Computer Simulation; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological