title: [Stability and compatibility of acetaminophen, ketoprofen and amoxicillin in a fail-safe intravenous administration set].
abstract: OBJECTIVE
  Intravenous infusion takes an important place in the current therapy in hospitals and pharmaceutical firms keep improving their infusion medical devices, particularly with the development of an intravenous administration set with an automatic infusion stop. The aim of our study consists in an evaluation of the stability of acetaminophen, ketoprofen and amoxicillin during infusion and stasis of drugs for several hours in the dropper chamber and in the tube of this device.
  
  
  METHODS
  Analytical study.
  
  
  METHODS
  Ten milligram per millilitre acetaminophen (acetaminophen 1 and acetaminophen 2), 1 mg/mL ketoprofen and 20 mg/mL amoxicillin were prepared and infused individually and successively with the intravenous administration set under ambient light and temperature. Collected samples of each drug during the infusion and after 24 hours of stasis in the medical device were monitored by a visual inspection, pH and osmolality assessment and chromatographic analysis of each drug with a validated stability-indicating method.
  
  
  RESULTS
  Repeated individual perfusions of 10 mg/mL acetaminophen 1 or 1 mg/mL ketoprofen are possible through a fail-safe intravenous administration set, while repeated individual amoxicillin infusions are not because of the unstability of this drug. There is also no problem to infuse successively acetaminophen and ketoprofen through this medical device because these drugs are stable. However, we underlined an incompatibility between acetaminophen 2 and ketoprofen, which advises against the use of intravenous administration set for successive infusions of these two drugs.
  
  
  CONCLUSIONS
  Despite the technical innovation of a fail-safe intravenous administration set, we have to stay aware of mixture consequences in intravenous infusion field.
authors.affiliation: Service de pharmacie, CHU de Clermont-Ferrand, France.
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: V
authors.initials: V
authors.lastname: Sautou
authors.forename: D
authors.initials: D
authors.lastname: Bourdeaux
authors.forename: J
authors.initials: J
authors.lastname: Chopineau
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D000658:Amoxicillin / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D004338:Drug Combinations; D004344:Drug Incompatibility; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000032:analysis*; D009994:Osmolar Concentration; D019999:Pharmaceutical Solutions; D015203:Reproducibility of Results
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D019999:Pharmaceutical Solutions; D000082:Acetaminophen; D000658:Amoxicillin; D007660:Ketoprofen