title: Two novel steroidal alkaloid glycosides from the seeds of Lycium barbarum.
abstract: Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sasaki
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Wang
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Asada
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D007422:Intestines / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D032305:Lycium / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013393:Sucrase / Q000037:antagonists & inhibitors
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; C572172:N-(3-((O-glucopyranosyl-(1-4)-O-(rhamnopyranosyl-(1-2))glucopyranosyl)oxy)-22-methoxyfurostan-26-yl)acetamide; C572173:N-(3-((O-glucopyranosyl-(1-4)-O-(rhamnopyranosyl-(1-2))glucopyranosyl)oxy)furost-20(22)-en-26-yl)acetamide; D010840:Phytosterols; D012503:Saponins; D013393:Sucrase