title: Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function.
abstract: OBJECTIVE
  To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH).
  
  
  METHODS
  This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo).
  
  
  RESULTS
  The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect.
  
  
  CONCLUSIONS
  Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH.
authors.affiliation: Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro.
authors.forename: Ricardo Mendes
authors.initials: RM
authors.lastname: Martins
authors.forename: Regina Helena Alves
authors.initials: RH
authors.lastname: Fonseca
authors.forename: Marta Maria Turano
authors.initials: MM
authors.lastname: Duarte
authors.forename: Vaneska Spinelli
authors.initials: VS
authors.lastname: Reuters
authors.forename: Márcia Martins
authors.initials: MM
authors.lastname: Ferreira
authors.forename: Cloyra
authors.initials: C
authors.lastname: Almeida
authors.forename: Alexandru
authors.initials: A
authors.lastname: Buescu
authors.forename: Patrícia de Fátima dos Santos
authors.initials: Pde F
authors.lastname: Teixeira
authors.forename: Mario
authors.initials: M
authors.lastname: Vaisman
mesh_terms: D000328:Adult; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D003971:Diastole / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013599:Systole / Q000187:drug effects; D013974:Thyroxine / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D013974:Thyroxine