title: [Clopidogrel resistance--clinical significance, pathogenesis and potential solutions].
abstract: Platelet activation and aggregation play a major role in the pathogenesis of acute coronary syndrome (ACS) and thrombotic complications following percutaneous coronary interventions (PCI). Antiplatelet therapy with aspirin (ASA) and/or clopidogrel remains one of the most effective therapies for the treatment of ACS and prevention of thrombotic complications following PCI. Nevertheless, not all patients achieve the desired laboratory and/or clinical effect following antiplatelet therapy. These patients have been termed "aspirin resistant" or "clopidogrel resistant". In recent years, several studies regarding clopidogrel resistance have been conducted, and a number of pharmacological therapies, together with new treatments, have been suggested. This review aims to provide an overview of the epidemiology, prevalence, clinical significance and potential solutions regarding clopidogrel resistance.
authors.affiliation: Heart Institute, Sheba Medical Center, Tel Hashomer, Israel. El.asher@gmail.com
authors.forename: Elad
authors.initials: E
authors.lastname: Asher
authors.forename: Hanoch
authors.initials: H
authors.lastname: Hod
authors.forename: Jonathan
authors.initials: J
authors.lastname: Buber
authors.forename: Roy
authors.initials: R
authors.lastname: Beigel
authors.forename: Ori
authors.initials: O
authors.lastname: Vatury
authors.forename: Shlomi
authors.initials: S
authors.lastname: Matetzky
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D001241:Aspirin / Q000494:pharmacology; D000077144:Clopidogrel; D004351:Drug Resistance; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D015995:Prevalence; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin