title: Numerical optimization of a microfluidic assisted microarray for the detection of biochemical interactions.
abstract: Finite element method analysis was applied to the characterization of the biomolecular interactions taking place in a microfluidic assisted microarray. Numerical simulations have been used for the optimization of geometrical and physical parameters of the sensing device. Different configurations have been analyzed and general considerations have been derived. We have shown that a parallel disposition of the sensing area allows the homogeneous formation of the target molecular complex in all the active zones of the microarray. Stationary and time dependent results have also been obtained.
authors.affiliation: Institute for Microelectronics and Microsystems, Naples Unit, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy. emanuele.orabona@na.imm.cnr.it
authors.forename: Emanuele
authors.initials: E
authors.lastname: Orabona
authors.forename: Ilaria
authors.initials: I
authors.lastname: Rea
authors.forename: Ivo
authors.initials: I
authors.lastname: Rendina
authors.forename: Luca
authors.initials: L
authors.lastname: De Stefano
mesh_terms: D003198:Computer Simulation; D020342:Finite Element Analysis; D007700:Kinetics; D046228:Microarray Analysis / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D009716:Numerical Analysis, Computer-Assisted; D011485:Protein Binding