title: [Effects of a neuroleptic analgesia with acepromazine on the blood perfusion of the canine kidney. Examination using the sonographic recordable blood circulation parameters of resistance index and pulsatility index].
abstract: OBJECTIVE
  Kidney failure after anaesthesia constitutes a serious clinical complication. A number of patients suffer from compensated kidney insufficiency, which may be transformed into an acute kidney insufficiency through additional stress, such as an operation and anaesthesia. The aim of the present study was to investigate the effects of a neurolept analgesia with acepromazine on sonographically accessible blood perfusion parameters.
  
  
  METHODS
  Following anaesthesia with acepromazine/l-methadone (0.1 mg/kg BW acepromazine, 0.5 mg/kg BW l-methadone) a sonographic examination of the left kidney was performed in 19 clinically healthy foxhound and beagle dogs. Every 5 minutes resistance index and pulsatility index as well as invasive blood pressure were measured and digitally recorded.
  
  
  RESULTS
  Within 5 minutes after induction of anaesthesia a transient increase of the mean arterial blood pressure occurred. After 10 minutes the blood pressure decreased to the initial value and remained essentially constant to the end of the investigation. Resistance index and pulsatility index showed a similar behaviour: After a small initial decrease during the first 5 minutes both parameters displayed a significant increase. This rise was very pronounced up to approximately 15 minutes and then flattened significantly until the end of the test period after 30 minutes. The values corresponded to those found in vessel stenosis.
  
  
  CONCLUSIONS
  Due to the described changes this type of anaesthesia should not be used in dogs with nephropathy, even though the results of this experimental study might not be necessarily transferable to the clinical patient.
authors.affiliation: Klinik für Kleintiere, Universität Leipzig, An den Tierkliniken 23, 04103 Leipzig. kiefer@kleintierklinik.uni-leipzig.de
authors.forename: I
authors.initials: I
authors.lastname: Kiefer
authors.forename: K
authors.initials: K
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Haarstrick
authors.forename: G
authors.initials: G
authors.lastname: Oechtering
authors.forename: M
authors.initials: M
authors.lastname: Alef
mesh_terms: D000075:Acepromazine / Q000009:adverse effects / Q000494:pharmacology*; D000698:Analgesia / Q000009:adverse effects / Q000662:veterinary; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D011673:Pulsatile Flow / Q000187:drug effects*; D012016:Reference Values; D014463:Ultrasonography; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D018492:Dopamine Antagonists; D000075:Acepromazine