title: Advanced paternal age and reproductive outcome.
abstract: Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.
authors.affiliation: Fertility and IVF Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Zofnat
authors.initials: Z
authors.lastname: Wiener-Megnazi
authors.forename: Ron
authors.initials: R
authors.lastname: Auslender
authors.forename: Martha
authors.initials: M
authors.lastname: Dirnfeld
mesh_terms: D000375:Aging / Q000502:physiology*; D025063:Chromosome Disorders / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate / Q000639:trends*; D012307:Risk Factors