title: [Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models].
abstract: Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed.
authors.forename: S G
authors.initials: SG
authors.lastname: Markushin
authors.forename: N A
authors.initials: NA
authors.lastname: Kantarov
authors.forename: S V
authors.initials: SV
authors.lastname: Artiushenko
authors.forename: I I
authors.initials: II
authors.lastname: Akopova
authors.forename: I B
authors.initials: IB
authors.lastname: Koptiaeva
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Bubnov
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001717:Birds; D001895:Boron / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002642:Chick Embryo; D004285:Dogs; D053126:Influenza A Virus, H7N7 Subtype / Q000187:drug effects*; D005585:Influenza in Birds / Q000188:drug therapy / Q000821:virology; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D008081:Liposomes; D001895:Boron; D000218:Adamantane