title: Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis.
abstract: We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.
authors.affiliation: Department of Anatomy, Veterinary School, University of Bristol, Bristol, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Hulin-Curtis
authors.forename: J L
authors.initials: JL
authors.lastname: Bidwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Perry
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002877:Chromosomes, Human / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics* / Q000378:metabolism; D053727:Interleukin-18 Receptor alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044465:White People / Q000235:genetics
chemical_list: C508572:IL18R1 protein, human; D020382:Interleukin-18; D053727:Interleukin-18 Receptor alpha Subunit