title: [Metal-binding capacity of metallothioneins of the liver of rats poisoned with heavy metals].
abstract: The functioning of metallothioneins in the liver of rats, poisoned with copper sulfate and cadmium sulfate has been investigated. By sequential chromatography on sephadex G-50 and DEAE-cellulose the authors obtained metallothioneins (MT-1, MT-1A, MT-2, MT-2a), which differ in molecular weight and composition of associated metals. Heavy metal poisoning leads to activation of synthesis and metal-binding function of metallothioneins, as well as to changes in the composition of their isoforms.
authors.forename: B O
authors.initials: BO
authors.lastname: Tsudzevich
authors.forename: I V
authors.initials: IV
authors.lastname: Kalinin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019187:Cadmium Compounds / Q000633:toxicity; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D056831:Coordination Complexes / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D019327:Copper Sulfate / Q000633:toxicity; D000075322:Heavy Metal Poisoning; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D019216:Metals, Heavy / Q000008:administration & dosage / Q000633:toxicity*; D008970:Molecular Weight; D011041:Poisoning; D011485:Protein Binding; D020033:Protein Isoforms / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D013431:Sulfates / Q000633:toxicity
chemical_list: D019187:Cadmium Compounds; D056831:Coordination Complexes; D019216:Metals, Heavy; D020033:Protein Isoforms; D013431:Sulfates; D008668:Metallothionein; C037123:cadmium sulfate; D019327:Copper Sulfate