title: Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.
abstract: Over the past several years, genome-wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments of risk and explain only a small proportion of familial clustering. To identify obstacles to future progress in genetic epidemiology research and provide recommendations to NIH for overcoming these barriers, the National Cancer Institute sponsored a workshop entitled "Next Generation Analytic Tools for Large-Scale Genetic Epidemiology Studies of Complex Diseases" on September 15-16, 2010. The goal of the workshop was to facilitate discussions on (1) statistical strategies and methods to efficiently identify genetic and environmental factors contributing to the risk of complex disease; and (2) how to develop, apply, and evaluate these strategies for the design, analysis, and interpretation of large-scale complex disease association studies in order to guide NIH in setting the future agenda in this area of research. The workshop was organized as a series of short presentations covering scientific (gene-gene and gene-environment interaction, complex phenotypes, and rare variants and next generation sequencing) and methodological (simulation modeling and computational resources and data management) topic areas. Specific needs to advance the field were identified during each session and are summarized.
authors.affiliation: Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. mechanil@mail.nih.gov
authors.forename: Leah E
authors.initials: LE
authors.lastname: Mechanic
authors.forename: Huann-Sheng
authors.initials: HS
authors.lastname: Chen
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Rao L
authors.initials: RL
authors.lastname: Divi
authors.forename: Ruzong
authors.initials: R
authors.lastname: Fan
authors.forename: Emily L
authors.initials: EL
authors.lastname: Harris
authors.forename: Kevin
authors.initials: K
authors.lastname: Jacobs
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Leal
authors.forename: Kimberly
authors.initials: K
authors.lastname: McAllister
authors.forename: Jason H
authors.initials: JH
authors.lastname: Moore
authors.forename: Dina N
authors.initials: DN
authors.lastname: Paltoo
authors.forename: Michael A
authors.initials: MA
authors.lastname: Province
authors.forename: Erin M
authors.initials: EM
authors.lastname: Ramos
authors.forename: Marylyn D
authors.initials: MD
authors.lastname: Ritchie
authors.forename: Kathryn
authors.initials: K
authors.lastname: Roeder
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Schaid
authors.forename: Matthew
authors.initials: M
authors.lastname: Stephens
authors.forename: Duncan C
authors.initials: DC
authors.lastname: Thomas
authors.forename: Clarice R
authors.initials: CR
authors.lastname: Weinberg
authors.forename: John S
authors.initials: JS
authors.lastname: Witte
authors.forename: Shunpu
authors.initials: S
authors.lastname: Zhang
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zöllner
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Feuer
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gillanders
mesh_terms: D057225:Data Mining / Q000379:methods; D059647:Gene-Environment Interaction; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods*; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000235:genetics; D010641:Phenotype; D014481:United States