title: Cancer permeates locally within ontogenetic compartments: clinical evidence and implications for cancer surgery.
abstract: The pathophysiologic process of local tumor spread is regarded as an isotropic infiltration of microscopic extensions of the malignant lesion irrespective of tissue boundaries. By contrast, the ontogenetic compartment theory states that malignant solid tumors are locally confined, for a relatively long phase during their natural course, to a permissive compartment derived from a common primordium in embryonic development. Tumor permeation is isotropic within the permissive ontogenetic compartment, but it is suppressed at the compartment borders. The validity of the ontogenetic compartment theory has been shown for cancer of the rectum and of the female lower genital tract. It is hypothesized that ontogenetic compartment resection, the translation of the theory into cancer surgery, holds a great potential to improve oncologic treatment results.
authors.affiliation: Department of Gynecology, Women's & Children's Center, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany. michael.hoeckel@uniklinik-leipzig.de
authors.forename: Michael
authors.initials: M
authors.lastname: Höckel
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009369:Neoplasms / Q000473:pathology / Q000601:surgery*