title: OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV.
abstract: Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.
authors.affiliation: Division of Behavioral Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Nugent
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lally
authors.forename: Larry
authors.initials: L
authors.lastname: Brown
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Knopik
authors.forename: John E
authors.initials: JE
authors.lastname: McGeary
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000483:Alleles; D063425:Binge Drinking / Q000235:genetics / Q000523:psychology*; D005838:Genotype; D015658:HIV Infections / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D009042:Motivation; D011569:Psychiatric Status Rating Scales; D017450:Receptors, Opioid, mu / Q000235:genetics*; D057566:Self Report; D018434:Sickness Impact Profile; D012959:Socioeconomic Factors; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D055815:Young Adult
chemical_list: C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu