title: Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences.
abstract: Minimotif Miner (MnM available at http://minimotifminer.org or http://mnm.engr.uconn.edu) is an online database for identifying new minimotifs in protein queries. Minimotifs are short contiguous peptide sequences that have a known function in at least one protein. Here we report the third release of the MnM database which has now grown 60-fold to approximately 300,000 minimotifs. Since short minimotifs are by their nature not very complex we also summarize a new set of false-positive filters and linear regression scoring that vastly enhance minimotif prediction accuracy on a test data set. This online database can be used to predict new functions in proteins and causes of disease.
authors.affiliation: Department of Computer Science and Engineering, University of Connecticut, Storrs, CT 06269-2155, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Mi
authors.forename: Jerlin Camilus
authors.initials: JC
authors.lastname: Merlin
authors.forename: Sandeep
authors.initials: S
authors.lastname: Deverasetty
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gryk
authors.forename: Travis J
authors.initials: TJ
authors.lastname: Bill
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Brooks
authors.forename: Logan Y
authors.initials: LY
authors.lastname: Lee
authors.forename: Viraj
authors.initials: V
authors.lastname: Rathnayake
authors.forename: Christian A
authors.initials: CA
authors.lastname: Ross
authors.forename: David P
authors.initials: DP
authors.lastname: Sargeant
authors.forename: Christy L
authors.initials: CL
authors.lastname: Strong
authors.forename: Paula
authors.initials: P
authors.lastname: Watts
authors.forename: Sanguthevar
authors.initials: S
authors.lastname: Rajasekaran
authors.forename: Martin R
authors.initials: MR
authors.lastname: Schiller
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D016384:Consensus Sequence; D030562:Databases, Protein; D008954:Models, Biological; D060066:Protein Interaction Maps; D011506:Proteins / Q000235:genetics; D020539:Sequence Analysis, Protein
chemical_list: D011506:Proteins