title: Mitochondrial-ER tethering: the inheritance of a functional unit.
abstract: A new study uncovers a novel role for the endoplasmic reticulum in tethering mitochondria specifically at the tip of the growing bud in Saccharomyces cerevisiae. Mitochondrial anchoring to the bud tip requires the tethering factor Mmr1, and the link to the ER is coupled to the cell cycle through a phosphorylation-dependent mechanism.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Ave, Rm 660, Montreal, Quebec H3A 2B4, Canada.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: McBride
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins