title: Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.
abstract: The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes-a type of glial cell-have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
authors.affiliation: Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
authors.forename: Mireille
authors.initials: M
authors.lastname: Bélanger
authors.forename: Igor
authors.initials: I
authors.lastname: Allaman
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Magistretti
mesh_terms: D001253:Astrocytes / Q000378:metabolism*; D001921:Brain / Q000098:blood supply* / Q000166:cytology / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006003:Glycogen / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D019344:Lactic Acid; D006003:Glycogen