title: Copper-free click--a promising tool for pre-targeted PET imaging.
abstract: The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [(18)F]2-fluoroethylazide ([(18)F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.
authors.affiliation: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, United Kingdom.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Evans
authors.forename: Rozanna L
authors.initials: RL
authors.lastname: Slade
authors.forename: Laurence
authors.initials: L
authors.lastname: Carroll
authors.forename: Graham
authors.initials: G
authors.lastname: Smith
authors.forename: Quang-De
authors.initials: QD
authors.lastname: Nguyen
authors.forename: Lisa
authors.initials: L
authors.lastname: Iddon
authors.forename: Nazila
authors.initials: N
authors.lastname: Kamaly
authors.forename: Henning
authors.initials: H
authors.lastname: Stöckmann
authors.forename: Finian J
authors.initials: FJ
authors.lastname: Leeper
authors.forename: Eric O
authors.initials: EO
authors.lastname: Aboagye
authors.forename: Alan C
authors.initials: AC
authors.lastname: Spivey
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry / Q000493:pharmacokinetics*; D003500:Cyclization; D005462:Fluorine Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D049268:Positron-Emission Tomography / Q000379:methods*; D014018:Tissue Distribution
chemical_list: C522266:2-fluoroethylazide; D000480:Alkynes; D001386:Azides; D005462:Fluorine Radioisotopes