title: Translocation t(2;11) is characteristic of collagenous fibroma (desmoplastic fibroblastoma).
abstract: Collagenous fibroma (desmoplastic fibroblastoma) is a rare, benign soft-tissue tumor composed of spindled and stellate-shaped cells embedded in a dense collagenous stroma. Recently, a translocation between chromosomes 2 and 11 or a rearrangement involving the chromosome 11q12 breakpoint was reported to be recurrent and unique in collagenous fibroma. Herein, we describe a case of collagenous fibroma arising in the left thigh of a 57-year-old man. Magnetic resonance imaging revealed a 5.5 cm soft-tissue mass deep relative to the vastus medialis with low signal intensity on both T1- and T2-weighted sequences. A marginal excision of the tumor was performed, and histopathologic features were consistent with collagenous fibroma. Cytogenetic analysis exhibited a reciprocal translocation involving the long arms of chromosomes 2 and 11. This finding suggests that the t(2;11) is likely to be of pathogenetic significance in a subset of collagenous fibromas.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. jnishio@cis.fukuoka-u.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Nishio
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Akiho
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Naito
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002889:Chromosomes, Human, Pair 2; D003582:Cytogenetics; D018220:Fibroma, Desmoplastic / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic