title: miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells             partly through down-regulation of the S100A8 protein.
abstract: microRNAs, a family of small non-coding RNAs, regulating approximately 30% of all human genes are deeply involved in the pathogenesis of several types of cancers, including laryngeal squamous cell carcinoma (LSCC). Here, we demonstrate that miR-24 is down-regulated in human LSCC tissues. Ectopic expression of miR-24 in Hep2 cells significantly induced cell morphology changes and inhibited cell proliferation and invasion ability in vitro by targeting S100A8 at the translational level. Meanwhile, miR-24 could significantly inhibit Hep2 cell invasion after S100A8 protein blockade. In conclusion, our results suggest that miR-24 may function as a tumor suppressor in LSCC through down-regulation of S100A8, which suggests that miR-24 could serve as a novel potential maker for LSCC therapy.
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang 110001, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Weineng
authors.initials: W
authors.lastname: Fu
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Shang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D020413:3' Untranslated Regions; D001483:Base Sequence; D040501:Calgranulin A / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D048430:Cell Shape; D015536:Down-Regulation; D057809:HEK293 Cells; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism*; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D013997:Time Factors; D014162:Transfection
chemical_list: D020413:3' Untranslated Regions; D040501:Calgranulin A; C543845:MIRN24 microRNA, human; D035683:MicroRNAs