title: Selective separation of magnolol using molecularly imprinted membranes.
abstract: Molecularly imprinted membranes (MIMs) for selective separation of magnolol were prepared by thermal polymerization using magnolol as the template, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, 2,2-azobisisobutyronitrile (AIBN) as the initiator, organic solvent as the porogen, methacrylamide (MAM) and acrylic acid (AA) as the functional monomers and cellulose acetate as the agglutinant. Commercial filter paper was used as the supporting material. The effects of different porogens and the ratio of functional monomers on the binding and recognition capacity of MIMs were investigated, and the morphology of the membranes was examined by scanning electron microscopy (SEM). The results showed that the MIMs have the highest selectivity to magnolol when the ratio of MAM/AA was 1:4 and tetrahydrofuran (THF) with dimethyl sulfoxide (DMSO) was used as the porogen. The morphology of the imprinted membranes after template extracting is much rougher with big cavities than that of the non-imprinted membranes (NIMs) and the imprinted membranes before template extracting. The MIMs can selectively separate the magnolol.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University of Technology, Key Laboratory of Pharmaceutical Engineering of Ministry of Education, Hangzhou, P. R. China.
authors.forename: Xing-Yi
authors.initials: XY
authors.lastname: Zhu
authors.forename: Zhang-Juan
authors.initials: ZJ
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Xie
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000178:Acrylamides; D000179:Acrylates; D001713:Biphenyl Compounds / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification; D017705:Lignans / Q000302:isolation & purification*; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting / Q000379:methods*; D058105:Polymerization
chemical_list: D000178:Acrylamides; D000179:Acrylates; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D017705:Lignans; D008567:Membranes, Artificial; C005498:magnolol; C036658:acrylic acid; C045985:methacrylamide