title: Anti-TNF agents and nail psoriasis: a single-center, retrospective, comparative study.
abstract: BACKGROUND
  Anti-tumor necrosis factor (TNF) agents' effect on psoriatic nails is still under investigation.
  
  
  OBJECTIVE
  To evaluate the therapeutic potentials of anti-TNF agents on psoriatic nails of patients suffering from moderate-to-severe plaque psoriasis.
  
  
  METHODS
  A retrospective study was conducted based on the medical records of 12 patients treated with infliximab, 14 with adalimumab and 13 with etanercept in daily practice. The Nail Psoriasis Severity Index (NAPSI) was recorded at baseline, week 12, 24 and 48.
  
  
  RESULTS
  At week 12, NAPSI was improved compared to baseline by 48.0% (range: 40.2-66.6%) with infliximab, 35.0% (range: 25.0-52.6%) with adalimumab and 41.7% (range: 39.5-46.4%) with etanercept. At week 24, NAPSI was improved by 80.4% (range: 66.6-90.2%) with infliximab, 70.2% (66.6-80.2%) with adalimumab and 76.1% (62.5-85.5%) with etanercept. At week 48, NAPSI was improved by 95.1% (range: 89.5-97.3%) with infliximab, 89.5% (75.0-94.8%) with adalimumab and 92.8% (84.3-96.0%) with etanercept. NAPSI percentage improvement was statistically significant across follow-up period (p = 0.000) for each anti-TNF treatment, as well as among treatments at all time points (week 12, p = 0.000; week 24, p = 0.001; week 48, p = 0.000).
  
  
  CONCLUSIONS
  All anti-TNF agents result in a significant improvement of NAPSI score, with infliximab given the precedence and followed by etanercept and adalimumab.
authors.affiliation: 2nd Dermatology Department, Aristotle University School of Medicine, Thessaloniki, Greece. docmouli@gmail.com
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Kyriakou
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Patsatsi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Sotiriadis
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy*; D011565:Psoriasis / Q000188:drug therapy*; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003879:Dermatologic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000068879:Adalimumab; D000068800:Etanercept