title: A comparative study of root defect coverage using an acellular dermal matrix with and without a recombinant human platelet-derived growth factor.
abstract: BACKGROUND
  The objective of this case series is to compare root defect coverage results and healing responses of bilateral recession defects treated with acellular dermal matrix (ADM) with and without recombinant human platelet-derived growth factor (rhPDGF).
  
  
  METHODS
  Seventeen patients with 40 bilateral gingival recession defects were compared. Each defect was ≥2 mm and treated with ADM and a coronally advanced flap. Using split-mouth design, the control-side ADM was hydrated in sterile saline, whereas the test-side ADM was hydrated in rhPDGF. The patients were evaluated at 1 week, 1 month, 3 months, and 6 months. Standardized measurements were taken preoperatively at 3 and 6 months. Healing was clinically assessed at 1 week and 1 month post-surgically.
  
  
  RESULTS
  Both test and control groups showed significant gain in root defect coverage over the 6-month period for all individuals, with the test group showing a 69.0% gain and the control group showing a 76.7% gain. Patients divided into Miller Class I and Class III defects were also found to have a significant gain in root defect coverage over 6 months. The test group showed 84.1% gain, and the control group showed 84.7% gain for Miller Class I defects. For Miller Class III defects, the test group showed 51.5% gain, and the control group showed a 60.8% gain. One week after surgery, 35% of the test group showed better healing, whereas 15% of the control group showed better healing. One month after surgery, 20% of the test group showed better healing, whereas 15% of the control group showed better healing.
  
  
  CONCLUSIONS
  Based on the results of this case series, there were no statistically or clinically significant differences in root defect coverage, keratinized tissue, clinical attachment level, or clinical healing for treatment of root recession with a coronally advanced flap and ADM with and without rhPDGF.
authors.affiliation: Department of Periodontics, Texas A&M University Health Science Center, Baylor College of Dentistry, Dallas, TX 75246, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Carney
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Rossmann
authors.forename: David G
authors.initials: DG
authors.lastname: Kerns
authors.forename: Daisha J
authors.initials: DJ
authors.lastname: Cipher
authors.forename: Terry D
authors.initials: TD
authors.lastname: Rees
authors.forename: Eric S
authors.initials: ES
authors.lastname: Solomon
authors.forename: Francisco
authors.initials: F
authors.lastname: Rivera-Hidalgo
authors.forename: M Miles
authors.initials: MM
authors.lastname: Beach
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001641:Bicuspid / Q000473:pathology; D003481:Cuspid / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007180:Incisor / Q000473:pathology; D007633:Keratins; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010512:Periodontal Index; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D016745:Root Planing; D012965:Sodium Chloride / Q000627:therapeutic use; D013357:Subgingival Curettage; D013524:Surgical Flaps; D019237:Tooth Cervix / Q000473:pathology; D014092:Tooth Root / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D012965:Sodium Chloride; D007633:Keratins