title: Bioluminescence imaging of energy depletion in vascular pathology: patent ductus arteriosus and atherosclerosis.
abstract: The artery wall may develop energy depletion due to insufficient nutritional supply. However, until recently it has not been possible to validate this hypothesis because no available technology has allowed assessment of energy metabolism with sufficient spatial resolution. We use high resolution bioluminescence metabolic imaging to study energy metabolism in two mechanistically different vascular pathologies: patent ductus arteriosus and atherosclerosis. Physiological energy depletion in postnatally constricting ductus arteriosus promotes permanent closure. Insufficient ductus energy depletion, common in preterm infants, is associated with persistent patent ductus arteriosus, a condition with significantly increased morbidity and mortality. In contrast, in atherosclerosis, energy depletion in the macrophage-rich lesion core promotes cell death contributing to lesion instability and disease progression.
authors.affiliation: Centre for R&D, Uppsala University/County Council of Gävleborg, Gävle, Sweden.
authors.forename: Olli
authors.initials: O
authors.lastname: Leppänen
authors.forename: Matias
authors.initials: M
authors.lastname: Ekstrand
authors.forename: Jan Hinrich
authors.initials: JH
authors.lastname: Bräsen
authors.forename: Max
authors.initials: M
authors.lastname: Levin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001158:Arteries / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism*; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000378:metabolism*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000378:metabolism; D008163:Luminescent Measurements / Q000379:methods*; D047928:Premature Birth / Q000378:metabolism; D019289:Pyruvic Acid / Q000378:metabolism; D011817:Rabbits
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; D006003:Glycogen; D005947:Glucose