title: Arsenic trioxide increases the sensitivity of 786-0 renal carcinoma cells to radiotherapy.
abstract: We evaluated the combined effect of As(2)O(3) and ionizing radiation on cultured renal carcinoma cells. The cells receiving both As(2)O(3) and radiotherapy had more DNA damage, more apoptosis, more reactive oxygen species produced, more cells in G(2)/M phase, and a lower mitochondrial membrane potential than cells treated with As(2)O(3) only or with radiotherapy only (for all comparisons, p < .05). Renal carcinoma cells can be sensitized to ionizing radiation with As(2)O(3), and combining As(2)O(3) and radiation had larger effects than As(2)O(3) only or radiation only.
authors.affiliation: Department of Urinary Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Su
authors.forename: XiaoMin
authors.initials: X
authors.lastname: Wang
authors.forename: WanHai
authors.initials: W
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.forename: ChunBo
authors.initials: C
authors.lastname: He
authors.forename: DeJun
authors.initials: D
authors.lastname: Yang
authors.forename: RuiHua
authors.initials: R
authors.lastname: An
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D004249:DNA Damage; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects / Q000528:radiation effects; D010087:Oxides / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D000077237:Arsenic Trioxide