title: New polyether triterpenoids from Laurencia viridis and their biological evaluation.
abstract: The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
authors.affiliation: University Institute for Bio-Organic Chemistry "Antonio González" (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain.
authors.forename: Francisco Cen
authors.initials: FC
authors.lastname: Pacheco
authors.affiliation: Institute of Molecular and Cellular Biology of Cancer, Cancer Research Center, CSIC-University of Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain.|APOINTECH, Spanish-Portuguese Center for Agriculture Research (CIALE), Scientific Park of the University of Salamanca, C/Rio Duero 12, Villamayor, Salamanca E-37185, Spain.
authors.forename: Janny A
authors.initials: JA
authors.lastname: Villa-Pulgarin
authors.affiliation: Institute of Molecular and Cellular Biology of Cancer, Cancer Research Center, CSIC-University of Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain.
authors.forename: Faustino
authors.initials: F
authors.lastname: Mollinedo
authors.affiliation: University Institute for Bio-Organic Chemistry "Antonio González" (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain.
authors.forename: Manuel Norte
authors.initials: MN
authors.lastname: Martín
authors.affiliation: University Institute for Bio-Organic Chemistry "Antonio González" (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain.
authors.forename: José Javier
authors.initials: JJ
authors.lastname: Fernández
authors.affiliation: University Institute for Bio-Organic Chemistry "Antonio González" (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain.
authors.forename: Antonio Hernández
authors.initials: AH
authors.lastname: Daranas
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes