title: Epidemic Intelligence Service investigations of respiratory illness, 1946-2005.
abstract: Infectious respiratory pathogens were the suspected cause of 480 outbreaks investigated by the Centers for Disease Control and Prevention's Epidemic Intelligence Service officers during 1946-2005. All epidemic-assistance investigation reports and associated articles from scientific journals were reviewed. Investigations identified 25 different infectious respiratory pathogens including, most frequently, tuberculosis, influenza, and legionellosis. Other bacterial-, viral-, and fungal-related pathogens also were identified. Epidemic-assistance investigations were notable for first identifying Legionnaires disease and Pontiac fever, hantavirus pulmonary syndrome, and new strains of human and avian influenza, as well as emerging challenges (e.g., multidrug-resistant tuberculosis and pneumococcus). The investigations provided clinical insights into such diseases as pulmonary anthrax and identified high risks of serious respiratory illnesses for persons infected with human immunodeficiency virus, other immunocompromised persons, and persons with diabetes. They identified settings placing persons at high risk of acquiring disease, including nursing homes, prisons, homeless shelters, and hospitals. Travel also placed persons at risk. Key environmental factors related to spread of diseases and occupational risks for brucellosis and psittacosis were identified. The outbreak investigations constitute a wealth of prevention experience and provide the basis for recommendations to mitigate outbreaks and reduce future risks.
authors.affiliation: Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA 30333, USA. sch1@cdc.gov
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Hadler
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Castro
authors.forename: Walter
authors.initials: W
authors.lastname: Dowdle
authors.forename: Lauri
authors.initials: L
authors.lastname: Hicks
authors.forename: Gary
authors.initials: G
authors.lastname: Noble
authors.forename: Renee
authors.initials: R
authors.lastname: Ridzon
mesh_terms: D002487:Centers for Disease Control and Prevention, U.S. / Q000266:history*; D004196:Disease Outbreaks / Q000266:history*; D004813:Epidemiology / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000266:history*; D014481:United States / Q000453:epidemiology