title: Improvements in quality of life associated with insulin analogue therapies in people with type 2 diabetes: results from the A1chieve observational study.
abstract: OBJECTIVE
  To determine the effects on quality of life after starting insulin with, or switching to, insulin analogue therapies in the 24-week, prospective, non-interventional, observational A(1)chieve study conducted across four continents in people with type 2 diabetes.
  
  
  METHODS
  Health-related quality of life (HRQoL) was assessed at baseline and at 24 weeks by the validated EQ-5D questionnaire (visual analogue score [VAS] and five dimensions) in 66,726 people who had started using basal insulin detemir, mealtime insulin aspart (with or without a basal insulin) or biphasic insulin aspart 30.
  
  
  RESULTS
  For the overall cohort, reported HRQoL increased significantly by 13.8 points from 63.4 points at baseline to 77.2 points at 24 weeks (p<0.001) (scale 1-100, 100=best health imaginable). Beginning or changing insulin was associated with a significant increase in HRQoL score (+15.0 points and +11.1 points, respectively), resulting in a similar score at 24 weeks in the two populations (77.8 and 75.9 points). Reported HRQoL also increased statistically significantly in people administering any insulin analogue regimen and across all regions, although there were some marked regional differences in reported HRQoL at baseline.
  
  
  CONCLUSIONS
  Compared with baseline scores, beginning insulin with, or switching to, insulin analogue therapies are associated with increased HRQoL.
authors.affiliation: Bhatia Hospital, Bombay Mutual Terrace, 534 Sandhurst Bridge, 3rd Floor, Mumbai 400007, India. apitxtbk@vsnl.net
authors.forename: Siddharth
authors.initials: S
authors.lastname: Shah
authors.forename: Alexey
authors.initials: A
authors.lastname: Zilov
authors.forename: Rachid
authors.initials: R
authors.lastname: Malek
authors.forename: Pradana
authors.initials: P
authors.lastname: Soewondo
authors.forename: Ole
authors.initials: O
authors.lastname: Bech
authors.forename: Leon
authors.initials: L
authors.lastname: Litwak
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007390:International Agencies; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin