title: An association between the serotonin transporter gene promoter polymorphism and smoking cessation among Japanese males.
abstract: The objective of this study was to replicate the associations between the serotonin transporter genotypes and smoking cessation and between these genotypes and long-term smoking cessation success (for 2 years or more). Two case-control designs were used in this study. The first case-control design consisted of 47 ex-smokers (cases) and 94 smokers (controls). The second case-control design consisted of the 12 ex-smokers who had succeeded in long-term smoking cessation (cases) and the 24 smokers (controls). In the first design, there was no significant difference in allele frequency and genotype distribution between cases and controls. In the second design, the S/S genotype frequency was higher in cases than in controls, but the difference did not reach slightly statistical significance. The present study suggests that individuals with the S/S genotype are more inclined to achieve long-term smoking cessation than others.
authors.affiliation: Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering,University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan.
authors.forename: Fuminao
authors.initials: F
authors.lastname: Sekiguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ando
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Yamakita
authors.forename: Zentaro
authors.initials: Z
authors.lastname: Yamagata
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D016540:Smoking Cessation / Q000706:statistics & numerical data*; D000074606:Smoking Prevention
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins