title: Antivirus and immune enhancement activities of sulfated polysaccharide from Angelica sinensis.
abstract: This study is to synthesize sulfated Angelica polysaccharides (APSs) and investigate the activity of one of the sulfated derivatives APS-1 on murine leukemia virus in vivo. Six sulfated derivatives with degree of sulfation ranging from 0.68 to 1.91 were obtained. And the virus replication was inhibited by APS-1 at the dose of 10 and 30 mg/kg (26% and 30% inhibition respectively). Furthermore, both the percentage of CD4(+) cells and CD4(+)/CD8(+) ratio in peripheral blood cells were significantly enhanced by APS-1 at 3-30 mg/kg. In addition, the reduced thymus/body weight index by murine leukemia virus infection was increased by ASP-1 in a dose dependent manner. These results suggest that APS-1 could not only inhibit virus replication, but also improve the immune function. APS-1 may be a potential new and better antiviral drug.
authors.affiliation: School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Tiehong
authors.initials: T
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.forename: Siyuan
authors.initials: S
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.forename: Qibing
authors.initials: Q
authors.lastname: Mei
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009052:Leukemia Virus, Murine / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D007155:Immunologic Factors; D011134:Polysaccharides; D013431:Sulfates