title: Melancholia.
abstract: OBJECTIVE
  The key question for melancholia is whether it should have status as a separate disorder and the literature of the last 12-24 months is surveyed largely from that perspective.
  
  
  RESULTS
  A number of interesting findings have appeared across a broad range of issues, but, with the possible exception of some large clinical trials, remain largely unreplicated.
  
  
  CONCLUSIONS
  Supporters of melancholia as a distinct entity will find little comfort in the recent literature.
authors.affiliation: Black Dog Institute, Randwick, Australia. d.hadzi-pavlovic@unsw.edu.au
authors.forename: Dusan
authors.initials: D
authors.lastname: Hadzi-Pavlovic
authors.forename: Philip
authors.initials: P
authors.lastname: Boyce
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D000928:Antidepressive Agents