title: Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease.
abstract: BACKGROUND
  Parkinson's disease (PD) is a progressive neurodegenerative disorder where the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in surviving neurons are primary histopathological hallmarks. Recent evidence points to mitochondrial dysfunction as a common upstream event in PD etiopathology.
  
  
  OBJECTIVE
  In this overview, we will discuss some of our findings that provide support for the mitochondrial cascade hypothesis, whereas mitochondrial deficits trigger PD pathology through alterations in microtubule integrity and macroautophagy.
  
  
  METHODS
  Using, as a PD model, cells that have PD patients' mitochondrial DNA, cells without mitochondrial DNA and MPP(+)-treated cells, we showed that mitochondrial metabolism alteration may underlie changes in the microtubular net and in the autophagic-lysosomal pathway.
  
  
  CONCLUSIONS
  Finally, we will endow a potential new therapeutic target for PD pathology.
authors.affiliation: Faculty of Medicine, University of Coimbra, Coimbra, Portugal. smacardoso@yahoo.com
authors.forename: S M
authors.initials: SM
authors.lastname: Cardoso
authors.forename: A R
authors.initials: AR
authors.lastname: Esteves
authors.forename: D M
authors.initials: DM
authors.lastname: Arduíno
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*