title: Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study.
abstract: We investigated prospectively factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either BM or peripheral blood stem cells (PBSCs) according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, blood allotransfusion, duration of hospital stay, and iron supplementation; however, differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons between the 2 procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of < 4 years and a BM harvest volume of > 20 mL/kg. Children < 4 years were at higher risk than older children for allotransfusion after BM harvest and there was a higher risk of complications from CVC placement before apheresis. We conclude that PBSC and BM collection are safe procedures in children.
authors.affiliation: Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. jstyczynski@cm.umk.pl
authors.forename: Jan
authors.initials: J
authors.lastname: Styczynski
authors.forename: Adriana
authors.initials: A
authors.lastname: Balduzzi
authors.forename: Lidia
authors.initials: L
authors.lastname: Gil
authors.forename: Myriam
authors.initials: M
authors.lastname: Labopin
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Hamladji
authors.forename: Sarah
authors.initials: S
authors.lastname: Marktel
authors.forename: M Akif
authors.initials: MA
authors.lastname: Yesilipek
authors.forename: Franca
authors.initials: F
authors.lastname: Fagioli
authors.forename: Karoline
authors.initials: K
authors.lastname: Ehlert
authors.forename: Martina
authors.initials: M
authors.lastname: Matulova
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Dalle
authors.forename: Jacek
authors.initials: J
authors.lastname: Wachowiak
authors.forename: Maurizio
authors.initials: M
authors.lastname: Miano
authors.forename: Chiara
authors.initials: C
authors.lastname: Messina
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Diaz
authors.forename: Christiane
authors.initials: C
authors.lastname: Vermylen
authors.forename: Matthias
authors.initials: M
authors.lastname: Eyrich
authors.forename: Isabel
authors.initials: I
authors.lastname: Badell
authors.forename: Peter
authors.initials: P
authors.lastname: Dreger
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gozdzik
authors.forename: Daphna
authors.initials: D
authors.lastname: Hutt
authors.forename: Jelena
authors.initials: J
authors.lastname: Rascon
authors.forename: Giorgio
authors.initials: G
authors.lastname: Dini
authors.forename: Christina
authors.initials: C
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D001800:Blood Specimen Collection / Q000009:adverse effects* / Q000379:methods*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D035781:Siblings; D014019:Tissue Donors / Q000523:psychology