title: CD16(+) natural killer cells play a limited role against primary dengue virus infection in tamarins.
abstract: CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo, CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. This resulted in the transient depletion of CD16(+) NK cells, whereas no significant effects on the overall levels or kinetics of plasma viral loads and antiviral antibodies were observed in the treated monkeys when compared to control monkeys. It remains elusive whether the CD16(-) NK subpopulation could play an important role in the control of primary DENV infection.
authors.affiliation: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, 1-1 Hachimandai, Tsukuba, Ibaraki 305-0843, Japan. ytomoyuki@pri.kyoto-u.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Omatsu
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Saito
authors.forename: Yuko
authors.initials: Y
authors.lastname: Katakai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Sayuki
authors.initials: S
authors.lastname: Iijima
authors.forename: Terue
authors.initials: T
authors.lastname: Kurosawa
authors.forename: Masataka
authors.initials: M
authors.lastname: Hamano
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Takasaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yasutomi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akari
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D003715:Dengue / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D051039:Leontopithecus; D017452:Receptors, IgG / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D017452:Receptors, IgG