title: Health and nutritional status of Wistar rats following subchronic exposure to CV127 soybeans.
abstract: This subchronic duration feeding study evaluated the nutritional and health status of rats fed diets containing CV127 at incorporation levels of 11% and 33%. For control comparisons, rats were also exposed to similar incorporation levels of the near isogenic conventional soybean variety (Conquista) and two other conventional soybean varieties (Monsoy, Coodetec). In spite of phenotypic differences among these four soybean varieties, there were no quantitative differences in their respective proximate and other compositional properties, including proteins, amino acids, antinutrients and nutritional cofactors. All diets were prepared by blending the respective processed soybean meal with ground Kliba maintenance meal at high (33%) and low (11%) incorporation levels, and the blended diets were fed to Wistar rats for about 91 days. Although there were some isolated parameters indicating statistically significant changes, these lacked consistency and a plausible mechanism and were thus assessed to be incidental. The totality of results demonstrate that CV127 soybeans are similar with respect to their nutritional value and systemic effects as its near isogenic conventional counterpart, as well as other conventional soybean varieties. Hence, introduction of AHAS gene into soybeans does not substantially alter its compositional properties, nor adversely affect its nutritional or safety status to mammals.
authors.affiliation: BASF Corporation, 26 Davis Drive, Research Triangle Park, NC 27709, USA. amechi.chukwudebe@basf.com
authors.forename: Amechi
authors.initials: A
authors.lastname: Chukwudebe
authors.forename: Laura
authors.initials: L
authors.lastname: Privalle
authors.forename: Andrew
authors.initials: A
authors.lastname: Reed
authors.forename: Christine
authors.initials: C
authors.lastname: Wandelt
authors.forename: Daniela
authors.initials: D
authors.lastname: Contri
authors.forename: Martina
authors.initials: M
authors.lastname: Dammann
authors.forename: Sibylle
authors.initials: S
authors.lastname: Groeters
authors.forename: Uwe
authors.initials: U
authors.lastname: Kaspers
authors.forename: Volker
authors.initials: V
authors.lastname: Strauss
authors.forename: Bennard
authors.initials: B
authors.lastname: van Ravenzwaay
mesh_terms: D000818:Animals; D001835:Body Weight; D005247:Feeding Behavior; D005260:Female; D008297:Male; D009752:Nutritional Status; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max