title: Preparation and characterization of uniform drug particles: dehydrocholic acid.
abstract: Two methods for the preparation of uniform dispersions of dehydrocholic acid of different morphologies are described. In the first case, the drug was dissolved in acetone and then re-precipitated by adding a non-solvent (either water or an aqueous stabilizer solution), which yielded rod-like particles. In the second procedure, spheres, consisting of small elongated subunits, were obtained by acidification of basic aqueous solutions of the drug. The resulting particles were characterized in terms of their structure and surface charge characteristics.
authors.affiliation: Center for Advanced Materials Processing, Clarkson University, Potsdam, NY 13699-5814, USA.
authors.forename: Amr Ali
authors.initials: AA
authors.lastname: Mohamed
authors.forename: Egon
authors.initials: E
authors.lastname: Matijević
mesh_terms: D000096:Acetone / Q000737:chemistry*; D003685:Dehydrocholic Acid / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012996:Solutions; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D012996:Solutions; D014867:Water; D000096:Acetone; D003685:Dehydrocholic Acid