title: [1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography].
abstract: OBJECTIVE
  Intestinal peristalsis can impede explorations and interventions using retrograde endoscopic cholangiopancreatography. Systemic spasmolytics are frequently employed to reduce this phenomenon, in spite of the adverse anti-cholinergic effects they are associated with. We proposed a formula using 1.6% peppermint oil solution with local use in order to avoid these adverse side effects.
  
  
  METHODS
  We formulated a preparation of 1.6% peppermint oil solution in accordance with the medical literature. The effectiveness of the formula was evaluated in a semi-qualitative manner according to the reduction in peristalsis.
  
  
  RESULTS
  We tested two different emulgents, and polysorbate provided the best results. The pilot study carried out with 8 patients demonstrated its effectiveness and safety in reducing intestinal peristalsis.
  
  
  CONCLUSIONS
  1.6% peppermint oil solution constitutes an effective and safe alternative to the use of systemic spasmolytics. More studies are needed with a larger sample size in order to establish its usefulness in normal clinical practice.
authors.affiliation: Servicio de Farmacia, Hospital Clínic, Barcelona, España. solanuria13@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Solà-Bonada
authors.forename: A M
authors.initials: AM
authors.lastname: de Andrés-Lázaro
authors.forename: M
authors.initials: M
authors.lastname: Roca-Massa
authors.forename: J M
authors.initials: JM
authors.lastname: Bordas-Alsina
authors.forename: C
authors.initials: C
authors.lastname: Codina-Jané
authors.forename: J
authors.initials: J
authors.lastname: Ribas-Sala
mesh_terms: D000293:Adolescent; D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D036142:Mentha piperita; D010276:Parasympatholytics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010528:Peristalsis / Q000187:drug effects; D019999:Pharmaceutical Solutions; D010865:Pilot Projects; D010938:Plant Oils / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
chemical_list: D010276:Parasympatholytics; D019999:Pharmaceutical Solutions; D010938:Plant Oils; C015424:peppermint oil