title: The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.
abstract: The review summarizes the current understanding of the role of hepcidin and ferroportin in normal iron homeostasis and its disorders. The various approaches to therapeutic targeting of hepcidin and ferroportin in iron-overload disorders (mainly hereditary hemochromatosis and β-thalassemia) and iron-restrictive anemias (anemias associated with infections, inflammatory disorders, and certain malignancies, anemia of chronic kidney diseases, and iron-refractory iron-deficiency anemia) are also discussed.
authors.affiliation: Department of Pulmonary & Critical Care Medicine, University of California-Los Angeles, Los Angeles, CA, USA. tganz@mednet.ucla.edu
authors.forename: Tomas
authors.initials: T
authors.lastname: Ganz
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Nemeth
mesh_terms: D000740:Anemia / Q000628:therapy*; D023181:Antimicrobial Cationic Peptides / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism*; D064451:Hepcidins; D006801:Humans; D019190:Iron Overload / Q000628:therapy*; D058990:Molecular Targeted Therapy; D000098742:Ferroportin
chemical_list: D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C578702:HAMP protein, human; D064451:Hepcidins; D000098742:Ferroportin