title: Corneal biomechanical properties and intraocular pressure measurement in Marfan patients.
abstract: OBJECTIVE
  To compare the biomechanical properties of the cornea and intraocular pressure (IOP) between patients with Marfan syndrome and age-matched controls.
  
  
  METHODS
  Departments of Ophthalmology and Genetics, Bakirkoy Maternity and Children Diseases Hospital, and Beyoglu Eye Education and Research Hospital, Istanbul, Turkey.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  This study comprised patients with Marfan syndrome (study group) and healthy individuals (control group). The study group was subdivided into patients with ectopia lentis and patients without ectopia lentis. In the right eye of each patient, the corneal hysteresis (CH), corneal resistance factor (CRF), Goldman-correlated IOP, and corneal-compensated IOP were recorded.
  
  
  RESULTS
  Overall, the mean CH, CRF, Goldman-correlated IOP, and corneal-compensated IOP were not significantly different between the study group and the control group. The mean CH was 9.9 mm Hg ± 1.2 (SD) in study eyes with ectopia lentis and 11.2 ± 1.5 mm Hg in study eyes without ectopia lentis (P=.016); the mean CRF was 8.2 ± 1.8 mm Hg and 11.3 ± 1.9 mm Hg, respectively (P<.001). The mean Goldman-correlated IOP was 11.7 ± 2.7 mm Hg in study eyes with ectopia lentis and 16.2 ± 4.3 in study eyes without ectopia lentis (P=.003); the mean corneal-compensated IOP was 13.5 ± 4.1 mm Hg and 15.6 ± 3.8 mm Hg, respectively (P=.07).
  
  
  CONCLUSIONS
  The CH, CRF, and Goldman-correlated IOP were significantly lower in the Marfan syndrome eyes with ectopia lentis than in the Marfan syndrome eyes without ectopia lentis.
authors.affiliation: Department of Ophthalmology, Bakirkoy Maternity and Children Diseases Hospital, Istanbul, Turkey. dr.necipkara@gmail.com
authors.forename: Necip
authors.initials: N
authors.lastname: Kara
authors.forename: Ercument
authors.initials: E
authors.lastname: Bozkurt
authors.forename: Okkes
authors.initials: O
authors.lastname: Baz
authors.forename: Hasan
authors.initials: H
authors.lastname: Altinkaynak
authors.forename: Huseyin
authors.initials: H
authors.lastname: Dundar
authors.forename: Kemal
authors.initials: K
authors.lastname: Yuksel
authors.forename: Ahmet Taylan
authors.initials: AT
authors.lastname: Yazici
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
authors.forename: Sukru
authors.initials: S
authors.lastname: Candan
mesh_terms: D000293:Adolescent; D000328:Adult; D001696:Biomechanical Phenomena / Q000502:physiology; D002648:Child; D003315:Cornea / Q000502:physiology*; D003430:Cross-Sectional Studies; D004479:Ectopia Lentis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008382:Marfan Syndrome / Q000503:physiopathology*; D055595:Mechanical Phenomena; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult