title: Insulin-like growth factor-1 (IGF-1) serum concentration among 7-year-old extremely low birth weight children--an indicator of growth problems.
abstract: BACKGROUND
  The study aim was to compare somatic development, body composition, insulin growth factor-1 (IGF-1) serum concentration and serum lipid profile between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) 7-year-old extremely low birth weight (ELBW) children and full-term (FT) controls.
  
  
  METHODS
  Fifty-seven AGA ELBW children [mean birth weight (BW) 850 g and mean gestational age (GA) 26.4 weeks] and 24 SGA ELBW children (mean BW 833 g, mean GA 29.5 weeks) were evaluated. The control group included 37 age- and sex-matched FT children from one outpatient center.
  
  
  RESULTS
  Nine AGA and four SGA were found to have short stature defined as height < 3rd percentile for chronological age (p = 0.9). In the AGA cohort, the results of weight, head circumference, triceps skin fold and body mass index (BMI) measurements were significantly reduced in the short-stature subgroup. IGF-1 serum concentrations differed significantly between short-stature and normal-stature subgroups (121 vs. 193 ng/mL; p = 0.02). In the SGA cohort, weight and serum concentrations of total cholesterol (5.03 vs. 4.26 mmol/L; p = 0.04), LDL cholesterol (3.24 vs. 2.38 mmol/L; p = 0.01) and IGF-1 (113 vs. 211 ng/mL; p = 0.01) differed significantly between the short-stature and normal-stature subgroups.
  
  
  CONCLUSIONS
  Short stature at the age of 7 years was diagnosed in a similar percentage of AGA and SGA former ELBW infants. In both cohorts short-stature children have significantly lower weight and serum IGF-1 levels. IGF-1 seems to be involved in prolonged growth restriction among ELBW infants, regardless of whether they were AGA or SGA.
authors.affiliation: Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland. kwintap@mp.pl
authors.forename: Przemko
authors.initials: P
authors.lastname: Kwinta
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Klimek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wójcik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Grudzień
authors.forename: Dorota
authors.initials: D
authors.lastname: Drozdz
authors.forename: Jacek Józef
authors.initials: JJ
authors.lastname: Pietrzyk
mesh_terms: D001823:Body Composition / Q000502:physiology; D001827:Body Height / Q000502:physiology; D002648:Child; D002657:Child Development / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006130:Growth Disorders / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development / Q000378:metabolism; D019102:Infant, Very Low Birth Weight / Q000254:growth & development* / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male
chemical_list: D008055:Lipids; D007334:Insulin-Like Growth Factor I