title: Lactococcus lactis-based vaccines from laboratory bench to human use: an overview.
abstract: Developing effective vaccines is an important weapon in the battle against potential pathogens and their evolving antibiotic resistance trends. Several vaccine delivery vectors have been investigated among which the generally regarded as safe (GRAS) Lactococcus lactis has a distinguished position. In this review, different factors affecting the efficacy of L. lactis-based vaccines are discussed. In addition, the issues of biological containment and pharmaceutical quality assurance of L. lactis vaccines are highlighted. These issues are critical for the success of medical translation of L. lactis-based vaccines from research laboratories to clinical use by ensuring consistent manufacturing of safe and efficacious vaccines.
authors.affiliation: Department of Pharmaceutical Microbiology, Alexandria University, Egypt. m.bahey-el-din@alexpharmacy.edu.eg
authors.forename: Mohammed
authors.initials: M
authors.lastname: Bahey-El-Din
mesh_terms: D004337:Drug Carriers / Q000008:administration & dosage* / Q000009:adverse effects; D005822:Genetic Vectors; D006801:Humans; D013294:Lactococcus lactis / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D013678:Technology, Pharmaceutical / Q000379:methods / Q000592:standards; D014612:Vaccines / Q000009:adverse effects / Q000235:genetics* / Q000276:immunology* / Q000592:standards
chemical_list: D004337:Drug Carriers; D014612:Vaccines