title: Small intestinal ion transport.
abstract: OBJECTIVE
  In this review, we focus on the recent (March 2010 to September 2011) advances in small intestinal ion transport, with particular emphasis on sodium, chloride, bicarbonate, and calcium transport mechanisms under physiological and pathophysiological conditions.
  
  
  RESULTS
  Knockout of NHERF1 and NHERF2 allowed translation of the data largely derived from the in-vitro models into a living organism. These studies also expand our knowledge about the complexity of intestinal transporter interactomes, define the role for scaffolding proteins in basal and regulated apical transport, and help identify potential targets for pharmacological approaches. We continue to accumulate novel information about the function and regulation of NHE3 (including its role in regulating paracellular Ca2+ flux), NHE8, as well as about the complexity of the intestinal Cl- and HCO3- transport in health and disease.
  
  
  CONCLUSIONS
  Thanks to the new genetically engineered mouse models, a significant progress has been made in our understanding of the role of NHERF proteins in regulation of intestinal Na+ absorption. Significant novel data on the coordinated function of bicarbonate, chloride, and sodium transporters contributes to our current views of the integrative physiology of the small intestinal electrolyte transport.
authors.affiliation: Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Science Center, Tucson, Arizona, USA. fghishan@peds.arizona.edu
authors.forename: Fayez K
authors.initials: FK
authors.lastname: Ghishan
authors.forename: Pawel R
authors.initials: PR
authors.lastname: Kiela
mesh_terms: D000818:Animals; D002118:Calcium; D027963:Chloride-Bicarbonate Antiporters / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000502:physiology*; D017136:Ion Transport; D010750:Phosphoproteins / Q000378:metabolism; D012964:Sodium; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism
chemical_list: D027963:Chloride-Bicarbonate Antiporters; D010750:Phosphoproteins; C000613386:Slc9a3 protein, mouse; C471945:Slc9a8 protein, mouse; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers; C093376:sodium-hydrogen exchanger regulatory factor; D012964:Sodium; D002118:Calcium