title: The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
authors.affiliation: Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Eichner
authors.forename: Tobias
authors.initials: T
authors.lastname: Knobloch
authors.forename: Heinz G
authors.initials: HG
authors.lastname: Floss
authors.forename: Jörg
authors.initials: J
authors.lastname: Fohrer
authors.forename: Kirsten
authors.initials: K
authors.lastname: Harmrolfs
authors.forename: Jekaterina
authors.initials: J
authors.lastname: Hermane
authors.forename: Anne
authors.initials: A
authors.lastname: Schulz
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Peter
authors.initials: P
authors.lastname: Spiteller
authors.forename: Florian
authors.initials: F
authors.lastname: Taft
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
mesh_terms: D000192:Actinomycetales / Q000235:genetics / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D016227:Benzoquinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D008453:Maytansine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; D050257:Tubulin Modulators; D008453:Maytansine; C015682:ansamitocins; C001277:geldanamycin