title: Asymmetric addition of dimethylzinc to alkylidenmalonates mediated by phosphorous ligands: a new synthetic route to floral fragrances.
abstract: Six new phosphite ligands were prepared and their efficiency as chiral ligands was investigated in the copper-catalyzed asymmetric conjugate addition of dimethylzinc to diethyl 3-phenylpropylidenmalonate (5), affording the addition product with ees up to 74%. Moreover, a simple and straightforward route to floral fragrances Phenoxanol, Citralis, and Nitrile Citralis in optically active form through the above cited reaction was proposed.
authors.affiliation: Dipartimento di Chimica A. M. Tamburro, Università della Basilicata, via dell’Ateneo Lucano, 10, Potenza 85100, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Superchi
authors.forename: Valeria
authors.initials: V
authors.lastname: Marchitiello
authors.forename: Laura
authors.initials: L
authors.lastname: Pisani
authors.forename: Patrizia
authors.initials: P
authors.lastname: Scafato