title: Effect of diffuse panbronchiolitis critical region 1 polymorphisms on the risk of aspirin-exacerbated respiratory disease in Korean asthmatics.
abstract: BACKGROUND
  The functional role of the human diffuse panbronchiolitis critical region 1 (DPCR1) gene, located in the major histocompatibility complex class I, has not been widely investigated. However, this gene is a well known genetic marker for diffuse panbronchiolitis, a disease  affecting human respiratory bronchioles. In this study we explored the association between polymorphisms in DPCR1 and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype.
  
  
  METHODS
  Genotyping of 6 polymorphisms was carried out in a total of 189 Korean asthmatic patients stratified  into 93 AERD cases and 96 aspirin tolerant asthma controls. Subjects who exhibited significant decrease of FEV(1) by aspirin provocation were identified as AERD subjects. Logistic and regression analyses were performed to investigate the association between DPCR1 polymorphisms and  the risk of AERD as well as FEV(1) decline.
  
  
  RESULTS
  Initial analysis revealed significant association of rs2517449 with AERD, with a P value of .03 via a recessive model; however, the association signal disappeared after multiple testing corrections. In addition, rs2517449  and rs2240804 also showed association signals with decline of FEV(1) after aspirin provocation (P = .007 and .03, respectively, in a recessive model). After testing for multiple comparisons, only the association signal from rs2517449 was retained (P(corr)  = .04), while other polymorphisms showed no associations with the risk of AERD and FEV(1) decline.
  
  
  CONCLUSIONS
  Our results show that polymorphisms in DPCR1 are not associated with the risk of AERD.
authors.affiliation: Department of Life Science, Sogang University, Seoul, Republic of Korea.
authors.forename: Jin Sol
authors.initials: JS
authors.lastname: Lee
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jason Yongha
authors.initials: JY
authors.lastname: Kim
authors.forename: Tae Joon
authors.initials: TJ
authors.lastname: Park
authors.forename: Charisse Flerida A
authors.initials: CF
authors.lastname: Pasaje
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.forename: Jong-Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D055963:Asthma, Aspirin-Induced / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D056910:Republic of Korea; D055815:Young Adult
chemical_list: C466100:MUCL3 protein, human; D009077:Mucins; D011506:Proteins