title: Lack of association between rs1024611 (-2581 A/G) polymorphism in CC-chemokine Ligand 2 and susceptibility to pulmonary Tuberculosis in Zahedan, Southeast Iran.
abstract: Approximately 5-10% of subjects infected with Mycobacterium           tuberculosis develop active tuberculosis. It has been proposed that genetic factors           determine the host's vulnerability to tuberculosis. Chemokine (C-C motif) ligand           2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1),           plays a key role in protective immunity against M. tuberculosis. The present study           was aimed to determine if there was an association between -2581 A/G single           nucleotide polymorphism of CCL2 and pulmonary tuberculosis (PTB) in a sample           of Iranian subjects. This case-control study was performed on 142 PTB and 166           healthy subjects. The polymorphism of CCL2 (rs1024611) was determined using           tetra amplification refractory mutational system-polymerase chain reaction (tetra           ARMS-PCR). There were no significant differences between PTB patients and           control subjects regarding -2581 A/G single nucleotide polymorphism of CCL2. In           conclusion, our results do not support an association of -2581 A/G polymorphism           of CCL2 with PTB susceptibility.
authors.affiliation: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Naderi
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.forename: H
authors.initials: H
authors.lastname: Karami
authors.forename: A
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: B
authors.initials: B
authors.lastname: Sharifi-Mood
authors.forename: H
authors.initials: H
authors.lastname: Kouhpayeh
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: S
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2