title: Central odontogenic fibroma: retrospective study of 8 clinical cases.
abstract: OBJECTIVE
  The central odontogenic fibroma (COF) is a benign odontogenic tumour derived from the dental mesenchymal tissues. It is a rare tumour and only 70 cases of it have been published. Bearing in mind the rareness of the tumour, 8 new cases of central odontogenic fibroma have been found by analyzing the clinical, radiological and histopathological characteristics of COF.
  
  
  METHODS
  A retrospective study was carried out on 3011 biopsies in the Service of Oral and Maxillofacial Surgery of the Dental Clinic of Barcelona University between January 1995 and March 2008. 85 odontogenic tumours were diagnosed of which 8 were central odontogenic fibroma. The radiological study was based on orthopantomographs, periapical and occlusal radiographies and computerised tomographics. The variables collected were: sex, age, clinical characteristics of the lesion, treatment received and possible reappearances of the tumour.
  
  
  RESULTS
  The central odontogenic fibroma represents 9.4% of all odontogenic tumours. Of the 8 cases, 5 were diagnosed in men and 3 in women. The average age was 19.9 years with an age range of 11 to 38 years. The most common location of the tumour was in the mandible. All cases were associated with unerupted teeth. Of the 8 tumours, 3 provoked rhizolysis of the adjacent teeth and 4 cases caused cortical bone expansion. 50% of the patients complained of pain associated to the lesion. No case of recurrence was recorded up to 2 years after the treatment.
  
  
  CONCLUSIONS
  Central odontogenic fibromas usually evolve asymptomatically although they can manifest very aggressively provoking dental displacement and rhizolysis. Radiologically, COF manifest as a uni or multilocular radiotransparent image although they can be indistinguishable from other radiotransparent lesions making diagnosis more difficult. COF treatment involves conservative surgery as well as follow-up patient checks.
authors.affiliation: School of Dentistry, University of Barcelona, Barcelona, Spain.
authors.forename: Radia
authors.initials: R
authors.lastname: Hrichi
authors.forename: Jordi
authors.initials: J
authors.lastname: Gargallo-Albiol
authors.forename: Leonardo
authors.initials: L
authors.lastname: Berini-Aytés
authors.forename: Cosme
authors.initials: C
authors.lastname: Gay-Escoda
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005350:Fibroma; D006801:Humans; D007573:Jaw Neoplasms / Q000175:diagnosis*; D008297:Male; D009808:Odontogenic Tumors / Q000175:diagnosis*; D012189:Retrospective Studies; D055815:Young Adult