title: Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
abstract: BACKGROUND
  Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. Evidence has shown that patients with morbid obesity have postprandial hypertriglyceridemia (HTG) and that this type of HTG is related to the degree of insulin resistance. Also, bariatric surgery produces a dramatic reduction in triglyceride levels. However, it is unknown whether patients with postprandial HTG have a different clinical evolution after bariatric surgery. The setting of our study was a university hospital.
  
  
  METHODS
  We studied 57 morbidly obese patients who had mild or severe postprandial HTG after fat overload (<30 mg/dL or >90 mg/dL increase in triglycerides, respectively). All the patients underwent bariatric surgery. After surgery, the anthropometric and biochemical variables and the Homeostasis Model Assessment of Insulin Resistance were measured for 1 year at 0, 15, 30, 45, 90, 180, and 365 days after surgery.
  
  
  RESULTS
  The patients with more severe postprandial HTG had a greater percentage of change in the Homeostasis Model Assessment of Insulin Resistance at 30, 90, and 180 days after surgery than the patients with less severe postprandial HTG. Multiple regression analysis showed that the postprandial triglyceride levels predict the variation in the Homeostasis Model Assessment of Insulin Resistance index, more so than did traditional variables, such as anthropometric, inflammatory, or hormonal data.
  
  
  CONCLUSIONS
  The postprandial HTG level might be the best predictor of improved insulin resistance in morbidly obese patients after bariatric surgery.
authors.affiliation: Endocrinology and Nutrition Service, Hospital Virgen de la Victoria, Malaga, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Queipo-Ortuño
authors.forename: Mercedes
authors.initials: M
authors.lastname: Clemente-Postigo
authors.forename: Diego
authors.initials: D
authors.lastname: Fernnadez-Garcia
authors.forename: Geltrude
authors.initials: G
authors.lastname: Mingrone
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
mesh_terms: D050110:Bariatric Surgery / Q000379:methods*; D015904:Biliopancreatic Diversion / Q000379:methods*; D048909:Diabetes Complications / Q000378:metabolism / Q000601:surgery; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000517:prevention & control*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D019518:Postprandial Period / Q000502:physiology; D011446:Prospective Studies
chemical_list: D004041:Dietary Fats