title: Genomic profiling of renal cell carcinoma in patients with end-stage renal disease.
abstract: The purpose of the present study was to determine the genomic profile of renal cell carcinoma (RCC) in end-stage renal disease (ESRD) by analyzing genomic copy number aberrations. Seventy-nine tumor samples from 63 patients with RCC-ESRD were analyzed by array comparative genomic hybridization using the Agilent Whole Human Genome 4 × 44K Oligo Micro Array (Agilent Technologies Inc., Palo Alto, CA, USA). Unsupervised hierarchical clustering analysis revealed that the 63 cases could be divided into two groups, Clusters A and B. Cluster A was comprised mainly of clear cell RCC (CCRCC), whereas Cluster B was comprised mainly of papillary RCC (PRCC), acquired cystic disease (ACD)-associated RCC, and clear cell papillary RCC. Analysis of the averaged frequencies revealed that the genomic profiles of Clusters A and B resembled those of sporadic CCRCC and sporadic PRCC, respectively. Although it has been proposed on the basis of histopathology that ACD-associated RCC, clear cell papillary RCC and PRCC-ESRD are distinct subtypes, the present data reveal that the genomic profiles of these types, categorized as Cluster B, resemble one another. Furthermore, the genomic profiles of PRCC, ACD-associated RCC and clear cell papillary RCC admixed in one tissue tended to resemble one another. On the basis of genomic profiling of RCC-ESRD, we conclude that the molecular pathogenesis of CCRCC-ESRD resembles that of sporadic CCRCC. Although various histologic subtypes of non-clear cell RCC-ESRD have been proposed, their genomic profiles resemble those of sporadic PRCC, suggesting that the molecular pathogenesis of non-CCRCC-ESRD may be related to that of sporadic PRCC.
authors.affiliation: Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsuura
authors.forename: Taichiro
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Lam Tung
authors.initials: LT
authors.lastname: Nguyen
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Chisato
authors.initials: C
authors.lastname: Nakada
authors.forename: Naoki
authors.initials: N
authors.lastname: Hijiya
authors.forename: Takahiro
authors.initials: T
authors.lastname: Narimatsu
authors.forename: Takeo
authors.initials: T
authors.lastname: Nomura
authors.forename: Fuminori
authors.initials: F
authors.lastname: Sato
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.forename: Shingo
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Numakura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Masao
authors.initials: M
authors.lastname: Seto
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Mimata
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Moriyama
mesh_terms: D002292:Carcinoma, Renal Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016000:Cluster Analysis; D055028:Comparative Genomic Hybridization; D020869:Gene Expression Profiling; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000235:genetics* / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D061346:Laser Capture Microdissection