title: Serum concentrations of human insulin-like growth factor-1 and levels of insulin-like growth factor-binding protein-5 in patients with nonalcoholic fatty liver disease:  association with liver histology.
abstract: OBJECTIVE
  In this study, we aimed to investigate the relationship between the histological features of nonalcoholic fatty liver disease (NAFLD) and serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-5 (IGFBP-5) to determine the usefulness of this relationship in clinical practice.
  
  
  METHODS
  Serum samples were collected from 92 patients with biopsy-proven NAFLD and 51 healthy controls and serum levels of IGF-1 and IGFBP-5 were assayed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum IGFBP-5 levels were correlated with liver steatosis, fibrosis, and nonalcoholic steatohepatitis scores. IGF-1 levels were significantly decreased in patients with moderate-to-severe fibrosis compared with patients with no or mild fibrosis.
  
  
  CONCLUSIONS
  Serum IGFBP-5 levels may be useful to differentiate both advanced fibrosis and definite nonalcoholic steatohepatitis from other NAFLD groups. Also, serum IGF-1 levels may be useful to differentiate advanced fibrosis in patients with NAFLD.
authors.affiliation: Department of Gastroenterology, Istanbul Goztepe Education and Research Hospital, Istanbul, Turkey. dryasarcolak@yahoo.com
authors.forename: Yasar
authors.initials: Y
authors.lastname: Colak
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Senates
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Ozturk
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: Ebru
authors.initials: E
authors.lastname: Zemheri
authors.forename: Feruze
authors.initials: F
authors.lastname: Yilmaz Enc
authors.forename: Celal
authors.initials: C
authors.lastname: Ulasoglu
authors.forename: Sebahat
authors.initials: S
authors.lastname: Aksaray
authors.forename: Sabriye Gulcin
authors.initials: SG
authors.lastname: Bozbeyoglu
authors.forename: Safak
authors.initials: S
authors.lastname: Kiziltas
authors.forename: Oya Ovunc
authors.initials: OO
authors.lastname: Kurdas
authors.forename: Ilyas
authors.initials: I
authors.lastname: Tuncer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D018450:Disease Progression; D005234:Fatty Liver / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D018975:Insulin-Like Growth Factor Binding Protein 5; D007334:Insulin-Like Growth Factor I