title: Development and characterization of zein-based microcarrier system for sustained delivery of aceclofenac sodium.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability of zein microspheres at gastric pH retarded the release of the entrapped drug and hence reduces the possibility of gastric injury. However, the in vitro release of aceclofenac was sustained up to 72 h at intestinal pH. Thus, zein microspheres pave the way for the development of safe and sustained delivery system for NSAIDs thereby achieving the desired therapeutic potential with reduced side effects for chronic inflammatory disorders.
authors.affiliation: Biomaterials Division, Central Leather Research Institute, TICEL Biopark, Taramani, Chennai, India.
authors.forename: K
authors.initials: K
authors.lastname: Karthikeyan
authors.forename: Rachita
authors.initials: R
authors.lastname: Lakra
authors.forename: Rama
authors.initials: R
authors.lastname: Rajaram
authors.forename: Purna Sai
authors.initials: PS
authors.lastname: Korrapati
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D002478:Cells, Cultured; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008863:Microspheres; D015028:Zein / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004008:Diclofenac; D015028:Zein; C056498:aceclofenac