title: State-of-the-art MS technology applications in lung disease.
abstract: Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.
authors.affiliation: Clinical Protein Science & Imaging, Biomedical Center, Dept of Measurement Technology & Industrial Electrical Engineering, Lund University, BMC C13, SE-221 84, Lund, Sweden. akos.vegvari@elmat.lth.se
authors.forename: Ákos
authors.initials: Á
authors.lastname: Végvári
authors.forename: Balázs
authors.initials: B
authors.lastname: Döme
mesh_terms: D006801:Humans; D008171:Lung Diseases / Q000378:metabolism* / Q000628:therapy; D008175:Lung Neoplasms / Q000378:metabolism* / Q000628:therapy; D013058:Mass Spectrometry / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000628:therapy