title: Novel effects of macrolide antibiotics on cardiovascular diseases.
abstract: Macrolide antibiotics are broadly used for the treatment of various microbial infections. However, they are also known to have multiple biologic effects, such as alteration of inflammatory factors and matrix metalloproteinases (MMPs). Because of controversial results in clinical trials, the effects of macrolides on cardiovascular diseases are still to be elucidated. It has been reported that MMP activity is upregulated in various cardiovascular diseases, such as myocarditis, cardiac transplant rejection and myocardial infarction. However, little is known about the effects of macrolides on cardiovascular diseases. We have reported that clarithromycin suppressed the development of myocarditis, cardiac rejection and myocardial ischemia using animal models. In this article, we reviewed the roles of MMPs in cardiovascular diseases and the effects of macrolides on the prevention of adverse tissue remodeling.
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan. junichisuzuki-circ@umin.ac.jp
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Suzuki
authors.forename: Masahito
authors.initials: M
authors.lastname: Ogawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hishikari
authors.forename: Ryo
authors.initials: R
authors.lastname: Watanabe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takayama
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D016027:Heart Transplantation; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D018942:Macrolides / Q000494:pharmacology*; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D009205:Myocarditis / Q000188:drug therapy / Q000503:physiopathology; D012038:Regeneration / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D018836:Inflammation Mediators; D018942:Macrolides; D020782:Matrix Metalloproteinases