title: [Corneal collagen cross-linking in keratoconus management].
abstract: Functional results of collagen UV cross-linking in keratoconus management are evaluated. 77 patients (87 eyes) with keratoconus stage I-II (Amsler classification) were under observation. All the patients received UV radiation (370 3m, 3mW/sm2) for 30 min with simultaneous instillation of "Dextralink" solution. Besides routine ophthalmological examination confocal biomicroscopy (HRT III, Heidelberg, Germany) and optical coherent tomography (Vizante-OCT, Carl Zeis, Germany) were performed before, in 1, 3, 6 and 12 months, 2 and 3 years after the procedure. By the 6th month the best corrected visual acuity showed improvement from 0.41 + 0.12 (M+m) till 0.52 + 0.01. Corneal refractive power decreased to 49.41 + 1.69 dpt by the last examination. UV cross-linking is a minimally invasive and effective option for management of keratoconus at the early stages, that let achieve biomechanical stabilization of the cornea and reduce progression rate.
authors.forename: M M
authors.initials: MM
authors.lastname: Bikbov
authors.forename: G M
authors.initials: GM
authors.lastname: Bikbova
authors.forename: A F
authors.initials: AF
authors.lastname: Khabibullin
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism / Q000528:radiation effects*; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D008297:Male; D018613:Microscopy, Confocal; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects; D012074:Remission Induction; D012256:Riboflavin / Q000008:administration & dosage / Q000009:adverse effects; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin