title: LH-RH agonists modulate amygdala response to visual sexual stimulation: a single case fMRI study in pedophilia.
abstract: Pedophilia is characterized by a persistent sexual attraction to prepubescent children. Treatment with anti-androgen agents, such as luteinizing hormone-releasing hormone (LH-RH) agonists, reduces testosterone levels and thereby sexual drive and arousal. We used functional magnetic resonance imaging (fMRI) to compare visual erotic stimulation pre- and on-treatment with the LH-RH agonist leuprolide acetate in the case of homosexual pedophilia. The pre-treatment contrasts of the erotic pictures against the respective neutral pictures showed an activation of the right amygdala and adjacent parahippocampal gyrus that decreased significantly under treatment with leuprolide acetate. Our single case fMRI study supports the notion that anti-androgens may modify amygdala response to visual erotic stimulation, a hypothesis that should be further examined in larger studies.
authors.affiliation: Department of Forensic Psychiatry, University of Basel, Basel, Switzerland. benedikt.habermeyer@upkbs.ch
authors.forename: Benedikt
authors.initials: B
authors.lastname: Habermeyer
authors.forename: Nadja
authors.initials: N
authors.lastname: Händel
authors.forename: Patrick
authors.initials: P
authors.lastname: Lemoine
authors.forename: Markus
authors.initials: M
authors.lastname: Klarhöfer
authors.forename: Erich
authors.initials: E
authors.lastname: Seifritz
authors.forename: Volker
authors.initials: V
authors.lastname: Dittmann
authors.forename: Marc
authors.initials: M
authors.lastname: Graf
mesh_terms: D000328:Adult; D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000726:Androgen Antagonists / Q000627:therapeutic use*; D059907:Functional Neuroimaging; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010378:Pedophilia / Q000188:drug therapy*; D010775:Photic Stimulation; D012725:Sexual Behavior / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide