title: History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer.
abstract: BACKGROUND
  Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life.
  
  
  OBJECTIVE
  The current study prospectively examined quality of life during chemotherapy in breast cancer patients with a history of resolved major depressive disorder (n = 29) and no history of depression (n = 144).
  
  
  METHODS
  Women with Stages 0-II breast cancer were assessed prior to and at the completion of chemotherapy. Major depressive disorder was assessed via structured interview and quality of life with the SF-36.
  
  
  RESULTS
  Patients with past major depressive disorder displayed greater declines in physical functioning relative to patients with no history of depression (p ≤ 0.01).
  
  
  CONCLUSIONS
  Findings suggest that breast cancer patients with a history of resolved major depressive disorder are at increased risk for declines in physical functioning during chemotherapy relative to patients with no history of depression.
authors.affiliation: Moffitt Cancer Center, Tampa, 33612 FL, USA. heather.jim@moffitt.org
authors.forename: Heather S L
authors.initials: HS
authors.lastname: Jim
authors.forename: Brent J
authors.initials: BJ
authors.lastname: Small
authors.forename: Susan
authors.initials: S
authors.lastname: Minton
authors.forename: Michael
authors.initials: M
authors.lastname: Andrykowski
authors.forename: Paul B
authors.initials: PB
authors.lastname: Jacobsen
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000523:psychology*; D003865:Major Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires