title: [The dehydroepiandrosterone sulfate influence on anxiety and depressive behaviour: participation of mu-opioid receptors].
abstract: The dehydroepiandrosterone sulfate (DHEAS) influence on anxiety and depressive behaviour was studied in animals after chronic stress exposures. It is shown that DHEAS (30 mg/kg) reduced anxiety in submission (with increased level of stress-induced anxiety resulting from chronic (20-days) defeats in aggressive interactions) of male mice of CBA/Lac strain in the "partition" test and in the plus-maze test, whereas in the control--only in the plus-maze test. DHEAS injection (30 mg/kg) in male Wistar rats decreased depressive behaviour in the Porsolt test in control and multiple (shuttling on the laboratory scrambler for 18 days by 1 hour in day) stressed animals. NaItrexone (0.25 mg/kg in mice and 0.1 mg/kg in rats) blocked anxiolytic and antidepressant-like effects of DHEAS. The findings suggest that these DHEAS effects are mediated by mu-opioid receptors.
authors.forename: M V
authors.initials: MV
authors.lastname: Ovsiukova
authors.forename: T A
authors.initials: TA
authors.lastname: Obut
authors.forename: S K
authors.initials: SK
authors.lastname: Saryg
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D003863:Depression / Q000378:metabolism*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D017450:Receptors, Opioid, mu; D019314:Dehydroepiandrosterone Sulfate