title: Editorial: bugs and drugs: insights into the pathogenesis of inflammatory bowel disease.
abstract: The dysbiosis hypothesis posits that perturbations in the gut microbiome may contribute to the development of inflammatory bowel disease (IBD). A recent Canadian population-based study has shown an association between new-onset IBD and antibiotic use in the 2-5 years preceding diagnosis. Though these findings do not establish a causal relationship, it supports the role of dysbiosis in the pathogenesis of IBD. Furthermore, the study reinforces the importance of the judicious use of antibiotics.
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Nguyen
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000139:chemically induced*; D003424:Crohn Disease / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents