title: Progress at last.
abstract: Refinement of protein structures from a correct topology to atomically detailed resolution has proven remarkably difficult. Jian et al. (in this issue of Structure) illustrate a significant advance in this task by carefully incorporating into the refinement process many body interactions extracted from fragment statistics.
authors.affiliation: Department of Chemistry and Biochemistry, Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX 78712, USA. ron@ices.utexas.edu
authors.forename: Ron
authors.initials: R
authors.lastname: Elber