title: Multiple pulmonary metastases from giant cell tumor of a hand.
abstract: Giant cell tumor (GCT) of bone has been described as the most challenging benign bone tumors. The majority of these tumors, classically, are involved in the epiphysis of long bones; however, on rare occasions, the tumors occur in the small bones of hands and feet. Although this disorder is benign, GCTs show a tendency of significant bone destruction, local recurrence and, occasionally, pulmonary metastasis. Approximately 3% of GCTs is known to metastasize to the lung. Herein, the authors describe an extremely rare case of multiple pulmonary metastatic GCTs in a 54-year-old man who presented asymptomatic pulmonary nodular lesions detected incidentally on chest x-ray of routine health checkup. He underwent chemotherapy with adriamycin and cisplatin and achieved nearly complete remission.
authors.affiliation: Department of Internal Medicine and Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea.
authors.forename: Jin Chang
authors.initials: JC
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine and Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea.
authors.forename: So Ri
authors.initials: SR
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine and Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea. Electronic address: leeyc@jbnu.ac.kr.
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Pathology, Chonbuk National University Medical School, Jeonju, South Korea.
authors.forename: Myung Ja
authors.initials: MJ
authors.lastname: Chung
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001707:Biopsy, Needle; D017824:Bone Cysts, Aneurysmal / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D018212:Giant Cell Tumor of Bone / Q000473:pathology*; D006801:Humans; D007262:Infusions, Intravenous; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D050279:Metacarpal Bones / Q000473:pathology*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D056910:Republic of Korea; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin