title: Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol.
abstract: OBJECTIVE
  To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability.
  
  
  METHODS
  Single-center, prospective, randomized clinical trial.
  
  
  METHODS
  Academic outpatient clinic.
  
  
  METHODS
  40 ASA physical status 1 and 2 patients with intellectual disability.
  
  
  METHODS
  Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol.
  
  
  METHODS
  The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded.
  
  
  RESULTS
  BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening.
  
  
  CONCLUSIONS
  Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
authors.affiliation: Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Maeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyawaki
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D056805:Consciousness Monitors; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008607:Intellectual Disability; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies; D016037:Single-Blind Method; D013997:Time Factors; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol