title: Imaging efficiency of an X-ray contrast agent-incorporated polymeric microparticle.
abstract: Biocompatible polymeric encapsulants have been widely used as a delivery vehicle for a variety of drugs and imaging agents. In this study, X-ray contrast agent (iopamidol) is encapsulated into a polymeric microparticle (polyvinyl alcohol) as a particulate flow tracer in synchrotron X-ray imaging system. The physical properties of the designed microparticles are investigated and correlated with enhancement in the imaging efficiency by experimental observation and theoretical interpretation. The X-ray absorption ability of the designed microparticle is assessed by Beer-Lambert-Bouguer law. Particle size, either in dried state or in solvent, primarily dominates the X-ray absorption ability under the given condition, thus affecting imaging efficiency of the designed X-ray contrast flow tracers.
authors.affiliation: Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, Korea.
authors.forename: Sungsook
authors.initials: S
authors.lastname: Ahn
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Jung
authors.forename: Jin Pyung
authors.initials: JP
authors.lastname: Lee
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D003287:Contrast Media / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007479:Iopamidol / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011522:Protons; D012997:Solvents / Q000737:chemistry; D017356:Synchrotrons / Q000295:instrumentation*
chemical_list: D003287:Contrast Media; D011522:Protons; D012997:Solvents; D011142:Polyvinyl Alcohol; D007479:Iopamidol