title: Prognostic determinants in prostate cancer.
abstract: Clinical outcomes in prostate cancer are heterogeneous, and given the high prevalence of the disease, there is a pressing need to identify clinically useful markers of prognosis. Many clinical, pathological, molecular, and genetic factors have been investigated in this capacity, although relatively few are routinely used. With a growing understanding of the molecular pathogenesis of prostate cancer, there is the potential that the next generation of makers will prove sufficiently robust to guide the optimal management of men with prostate cancer. Here, we review the various clinical and molecular prognostic determinants in prostate cancer.
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Neil E
authors.initials: NE
authors.lastname: Martin
authors.forename: Lorelei A
authors.initials: LA
authors.lastname: Mucci
authors.forename: Massimo
authors.initials: M
authors.lastname: Loda
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Depinho
mesh_terms: D000818:Animals; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen