title: The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging.
abstract: OBJECTIVE
  To assess the prevalence of the frailty syndrome and its associated variables among the older adult population in the province of Toledo (Spain).
  
  
  METHODS
  Data were taken from the Toledo Study for Healthy Aging, a population-based study conducted on 2,488 individuals aged 65 years and older. Study participants were selected by a two-stage random sampling from the municipal census of Toledo, covering both institutionalized and community dwelling persons from rural and urban settings. Data were collected from 2006 to 2009, and included information on social support, activities of daily living, comorbidity, physical activity, quality of life, depressive symptoms, and cognitive function. In addition, a nurse collected anthropometric data, conducted tests of physical performance (walk speed, upper and lower extremities strength, and the stand-and-sit from a chair test) and obtained a blood sample. The diagnosis of the frailty syndrome was based on the Fried criteria (weakness, low speed, low physical activity, exhaustion, and weight loss).
  
  
  RESULTS
  In total, 41.8% (95% confidence interval [CI] 39.4-44.2%) of the study participants were prefrail, and 8.4% (95% CI 7.1-9.8%) were frail. There were no differences in the prevalence of frailty by sex, level of education, occupation, marital status, or place of residence. The frequency of the frailty syndrome increased with age, and was higher in those with disability, depression, hip fracture and other comorbidity, such as cardiovascular disease and disorders of the central nervous system.
  
  
  CONCLUSIONS
  The prevalence of the frailty syndrome in older Spanish adults is high and similar to that reported in other populations in the Mediterranean basin.
authors.affiliation: Division of Geriatric Medicine, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain. franjogarcia@telefonica.net
authors.forename: F J
authors.initials: FJ
authors.lastname: Garcia-Garcia
authors.forename: G
authors.initials: G
authors.lastname: Gutierrez Avila
authors.forename: A
authors.initials: A
authors.lastname: Alfaro-Acha
authors.forename: M S
authors.initials: MS
authors.lastname: Amor Andres
authors.forename: M
authors.initials: M
authors.lastname: De Los Angeles De La Torre Lanza
authors.forename: M V
authors.initials: MV
authors.lastname: Escribano Aparicio
authors.forename: S
authors.initials: S
authors.lastname: Humanes Aparicio
authors.forename: J L
authors.initials: JL
authors.lastname: Larrion Zugasti
authors.forename: M
authors.initials: M
authors.lastname: Gomez-Serranillo Reus
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez-Artalejo
authors.forename: L
authors.initials: L
authors.lastname: Rodriguez-Manas
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D006233:Persons with Disabilities; D015444:Exercise; D005221:Fatigue / Q000453:epidemiology*; D005260:Female; D016330:Frail Elderly; D005684:Gait; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009043:Motor Activity; D053580:Muscle Strength; D018908:Muscle Weakness / Q000453:epidemiology*; D010809:Physical Fitness; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D013577:Syndrome; D015431:Weight Loss