title: Changes in plasma membrane phospholipids inhibit antibody-mediated lysis.
abstract: A variety of mechanisms have been proposed to explain how tumors evade immune destruction. This work has identified one such mechanism that determines susceptibility to immune lysis; membrane phospholipid composition altered susceptibility to antibody plus complement (Ab+C)-mediated lysis. Effects on antibody plus complement-mediated lysis were correlated with levels of major histocompatibility complex (MHC) molecules but not inherent resistance to complement damage. This cellular mechanism could be a means by which tumor cells escape immune detection and destruction.
authors.affiliation: Department of Immunobiology, University of Arizona, Tucson, AZ 85724, United States. davidh@email.arizona.edu
authors.forename: David T
authors.initials: DT
authors.lastname: Harris
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002462:Cell Membrane / Q000737:chemistry* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010743:Phospholipids / Q000737:chemistry* / Q000276:immunology*; D019139:Tumor Escape
chemical_list: D000906:Antibodies; D010743:Phospholipids