title: Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi.
abstract: A phytochemical study of the ethyl acetate extract of the roots and adventitious roots of Spirotropis longifolia, a monodominant tree species of the Guianan rainforest, has allowed the isolation of three compounds: 2-hydroxy-8,9-methylenedioxy-2',2'-dimethylpyrano-[5',6':4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin A), 2-hydroxy-8,9-methylenedioxy-2',2'-dimethyl-3',4'-dihydropyrano-[5',6':4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin B), and 5,7-dihydroxy-6,8-diprenyl-2'''',2''''-dimethylpyrano[5'''',6'''': 3',4']-isoflavone (spirotropone). In addition, 10 known compounds, trans-oxyresveratrol, trans-resveratrol, piceatannol, daidzein, genistein, isoprunetin, lupeol, latifolol, gnetin D and gnetin E, were also isolated. These compounds were evaluated for their antifungal activity and their cytotoxicity, and their structures were established by 1D and 2D NMR, HRMS, CD and optical rotation measurements.
authors.affiliation: CNRS, UMR ECOFOG, Université des Antilles et de la Guyane, 97300 Cayenne, France.
authors.forename: Charlie
authors.initials: C
authors.lastname: Basset
authors.forename: Alice M S
authors.initials: AM
authors.lastname: Rodrigues
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Maria R R
authors.initials: MR
authors.lastname: Silva
authors.forename: Norberto P
authors.initials: NP
authors.lastname: Lopes
authors.forename: Daniel
authors.initials: D
authors.lastname: Sabatier
authors.forename: Emile
authors.initials: E
authors.lastname: Fonty
authors.forename: Laila S
authors.initials: LS
authors.lastname: Espindola
authors.forename: Didier
authors.initials: D
authors.lastname: Stien
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots
chemical_list: D000935:Antifungal Agents; D007529:Isoflavones; D010936:Plant Extracts; C572840:spirotropin A; C572838:spirotropin B; C572839:spirotropin C