title: Does colorectal cancer in ulcerative colitis patients constitute a risk for chemotherapy refractoriness?:a systemic approach by detailed analysis via the electronic tumor base documentation system.
abstract: BACKGROUND
  Ulcerative colitis (UC) patients may develop colorectal cancer (CRC), especially with pancolitis and longer UC duration. The question whether CRC with underlying UC has a dismal prognosis remains unsettled.
  
  
  METHODS
  We performed an electronic tumor base documentation (eTBD) search of CRC and UC patients at our department to address whether (1) CRC prognosis is impaired and (2) defined risks can be determined.
  
  
  RESULTS
  With the inclusion of an index patient with UC and unresponsive CRC, 20 additional patients were identified via eTBD. Chemotherapy response was less substantial, with complete response or stable disease in 3 patients each, but rapidly progressing or refractory disease in 15/21 patients. 12 out of the 21 patients died. Our hazard ratio analysis revealed International Union against Cancer (UICC) stage IV and III disease, grade 3 tumors, longer latency from UC to CRC and age >60 years as potential risks. Median progression-free survival and overall survival were 48 and 82 months, respectively. Time from tumor dissemination to death was 10 months.
  
  
  CONCLUSIONS
  The prognosis of CRC in UC patients is not necessarily impaired, albeit chemotherapy response with disseminated disease may be unfavorable. Our data should be enlarged by subsequent analyses to better elucidate whether response in UC and CRC is more challenging and defined risks can be confirmed.
authors.affiliation: Department of Hematology and Oncology, Clinical Trials Unit, University Medical Center Freiburg, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Engelhardt
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ihorst
authors.forename: Josefina
authors.initials: J
authors.lastname: Udi
authors.forename: Martina
authors.initials: M
authors.lastname: Kleber
authors.forename: Justyna
authors.initials: J
authors.lastname: Rawluk
authors.forename: Ralph
authors.initials: R
authors.lastname: Wäsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000401:mortality*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D015897:Comorbidity; D019008:Drug Resistance, Neoplasm; D057286:Electronic Health Records / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D017211:Treatment Failure; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents