title: Weaving the web of ER tubules.
abstract: How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that include the atlastins, Sey1p, and RHD3.
authors.affiliation: Department of Genetics and Cell Biology, College of Life Sciences, and Tianjin Key Laboratory of Protein Sciences, Nankai University, Tianjin 300071, China. huj@nankai.edu.cn
authors.forename: Junjie
authors.initials: J
authors.lastname: Hu
authors.forename: William A
authors.initials: WA
authors.lastname: Prinz
authors.forename: Tom A
authors.initials: TA
authors.lastname: Rapoport
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D059828:Plant Cells / Q000378:metabolism; D014714:Vertebrates; D015003:Yeasts / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D019204:GTP-Binding Proteins