title: Factors predicting quality of life in a group of Polish subjects with multiple sclerosis: accounting for functional state, socio-demographic and clinical factors.
abstract: OBJECTIVE
  Quality of life (QoL) has presently a firmly established position as an important endpoint in medical care. Multiple sclerosis (MS) is a chronic neurological disease with considerable effect on patients' QoL. QoL of MS patients from many European countries has already been assessed but little is known on health-related QoL of Polish subjects with MS. Few studies have taken into consideration multiple predictors of QoL. The aim of this study was to elicit the most relevant factors that determine QoL of Polish group of MS patients. Socio-demographic and clinical factors as well as the influence of disability level were analyzed in this study.
  
  
  METHODS
  173 MS patients and 86 healthy controls underwent assessment using the Mini Mental Status Examination, WHOQOL-100, Beck Depression Inventory and Fatigue Severity Scale. Data were analyzed by a stepwise linear regression analysis.
  
  
  RESULTS
  MS patients had significantly worse global QoL and worse QoL in physical and psychological health domains, lower level of independence, worse social relations and were less satisfied with the surrounding environment they lived in compared with healthy controls (p<0.05). MS subjects had also higher level of depression and fatigue compared to healthy controls (p<0.05).
  
  
  CONCLUSIONS
  The study determined that the strongest predictors of global QoL of Polish MS patients were depression, disability level and fatigue.
authors.affiliation: Department of Neurology, Medical University of Lublin, Poland. ewapap@yahoo.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Papuć
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Stelmasiak
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003863:Depression / Q000523:psychology; D004185:Disability Evaluation; D004651:Employment; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000523:psychology*; D018763:Muscle Fatigue / Q000502:physiology; D009483:Neuropsychological Tests; D011044:Poland; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012737:Sex Factors; D012959:Socioeconomic Factors; D016138:Walking / Q000502:physiology; D055815:Young Adult