title: Assessment of mechanical ventilation parameters on respiratory mechanics.
abstract: Better understanding of airway mechanics is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems in intensive-care medicine, as well as pulmonary medicine. Mechanical ventilation depends on several parameters, all of which affect the patient outcome. As there are no systematic numerical investigations of the role of mechanical ventilation parameters on airway mechanics, the objective of this study was to investigate the role of mechanical ventilation parameters on airway mechanics using coupled fluid-solid computational analysis. For the airway geometry of 3 to 5 generations considered, the simulation results showed that airflow velocity increased with increasing airflow rate. Airway pressure increased with increasing airflow rate, tidal volume and positive end-expiratory pressure (PEEP). Airway displacement and airway strains increased with increasing airflow rate, tidal volume and PEEP form mechanical ventilation. Among various waveforms considered, sine waveform provided the highest airflow velocity and airway pressure while descending waveform provided the lowest airway pressure, airway displacement and airway strains. These results combined with optimization suggest that it is possible to obtain a set of mechanical ventilation strategies to avoid lung injuries in patients.
authors.affiliation: Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA, USA. rmpidaparti@vcu.edu
authors.forename: Ramana M
authors.initials: RM
authors.lastname: Pidaparti
authors.forename: Kittisak
authors.initials: K
authors.lastname: Koombua
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Ward
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008953:Models, Anatomic; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D013990:Tidal Volume