title: Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent.
abstract: The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et(2)NSF(2)]BF(4)) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.
authors.affiliation: Department of Chemistry, Université Laval, Québec, Canada.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Pouliot
authors.forename: Laetitia
authors.initials: L
authors.lastname: Angers
authors.forename: Jean-Denys
authors.initials: JD
authors.lastname: Hamel
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Paquin
mesh_terms: D003500:Cyclization; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D006845:Hydrocarbons, Fluorinated; D010069:Oxadiazoles; D013457:Sulfur Compounds; C551695:diethylaminodifluorosulfinium tetrafluoroborate