title: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
abstract: Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
authors.forename: Liming
authors.initials: L
authors.lastname: Huang
authors.forename: Xu
authors.initials: X
authors.lastname: Che
authors.forename: Guoliang
authors.initials: G
authors.lastname: Jiang
authors.forename: Dianke
authors.initials: D
authors.lastname: Yu
authors.forename: Xianghong
authors.initials: X
authors.lastname: Yang
authors.forename: Guangwen
authors.initials: G
authors.lastname: Cao
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Zhou
authors.forename: Chaohui
authors.initials: C
authors.lastname: Zuo
authors.forename: Chunyou
authors.initials: C
authors.lastname: Wang
authors.forename: Xianghong
authors.initials: X
authors.lastname: Zhang
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xianjun
authors.initials: X
authors.lastname: Yu
authors.forename: Wanjin
authors.initials: W
authors.lastname: Dai
authors.forename: Zhaoshen
authors.initials: Z
authors.lastname: Li
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Luming
authors.initials: L
authors.lastname: Liu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Chen
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Wang
authors.forename: Kan
authors.initials: K
authors.lastname: Zhai
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Menghong
authors.initials: M
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zheng
authors.forename: Siu Tim
authors.initials: ST
authors.lastname: Cheung
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Jia
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Wang
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide