title: Proximal femoral allograft in revision hip surgery with severe femoral bone loss: a systematic review and meta-analysis.
abstract: This study provides an objective appraisal of available evidence regarding the outcome of proximal femoral allograft for reconstruction of massive proximal femoral bone loss. The primary outcomes were rates of success, structural failure, and infection. A systematic literature review identified 16 studies with a minimum 2-year follow-up. Estimated pooled effect analysis performed with heterogeneity quantified using I(2) and τ(2). The total cohort included 498 patients with a mean follow-up of 8.1 years. The pooled success rate was 81%, pooled structural failure rate of 15%, and pooled infection rate of 8%. Significant heterogeneity was observed in structural failure rates (I(2) = 47.9, τ(2) = 0.29, P < .05). Proximal femoral allografts afford viable reconstruction for massive femoral bone loss when performed by experienced.
authors.affiliation: Department of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Benedict A
authors.initials: BA
authors.lastname: Rogers
authors.forename: Amir
authors.initials: A
authors.lastname: Sternheim
authors.forename: Maria
authors.initials: M
authors.lastname: De Iorio
authors.forename: David
authors.initials: D
authors.lastname: Backstein
authors.forename: Oleg
authors.initials: O
authors.lastname: Safir
authors.forename: Allan E
authors.initials: AE
authors.lastname: Gross
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D001862:Bone Resorption / Q000601:surgery*; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods*; D015331:Cohort Studies; D004868:Equipment Failure; D005269:Femur / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D016459:Prosthesis-Related Infections; D012086:Reoperation; D014184:Transplantation, Homologous; D016896:Treatment Outcome