title: Biosynthetic pathways and the role of the MAS receptor in the effects of Angiotensin-(1-7) in smooth muscles.
abstract: Ang-(1-7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1-7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1-7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1-7) in the gastrointestinal system. The Ang-(1-7) actions are mediated by a distinct, functional, Ang-(1-7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion. This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1-7) in diverse systems.
authors.affiliation: Division of Gastroenterology & Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Marcio Augusto
authors.initials: MA
authors.lastname: Fressatto de Godoy
authors.forename: Larissa
authors.initials: L
authors.lastname: Pernomian
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: de Oliveira
authors.forename: Satish
authors.initials: S
authors.lastname: Rattan