title: Ultrasensitive and selective non-enzymatic glucose detection using copper nanowires.
abstract: In the pursuit of more economical electrocatalysts for non-enzymatic glucose sensors, one-dimensional Cu nanowires (Cu NWs) with uniform size distribution and a large aspect ratio (>200) were synthesized by a facile, scalable, wet-chemistry approach. The morphology, crystallinity, and surface property of the as-prepared Cu NWs were examined by SEM, XRD, and XPS, respectively. The electrochemical property of Cu NWs for glucose electrooxidation was thoroughly investigated by cyclic voltammetry. In the amperometric detection of glucose, the Cu NWs modified glassy carbon electrode exhibited an extraordinary limit of detection as low as 35 nM and a wide dynamic range with excellent sensitivity of 420.3 μA cm(-2) mM(-1), which was more than 10,000 times higher than that of the control electrode without Cu NWs. The performance of the developed glucose sensor was also independent to oxygen concentration and free from chloride poisoning. Furthermore, the interference from uric acid, ascorbic acid, acetaminophen, fructose, and sucrose at the level of their physiological concentration were insignificant, indicating excellent selectivity. Finally, good accuracy and high precision for the quantification of glucose concentration in human serum samples implicate the applicability of Cu NWs in sensitive and selective non-enzymatic glucose detection.
authors.affiliation: Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Su
authors.forename: Dan
authors.initials: D
authors.lastname: Manuzzi
authors.forename: Honorio Valdés Espinosa
authors.initials: HV
authors.lastname: de los Monteros
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Jia
authors.forename: Danqun
authors.initials: D
authors.lastname: Huo
authors.forename: Changjun
authors.initials: C
authors.lastname: Hou
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D003300:Copper / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005949:Glucose Oxidase; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003300:Copper; D005949:Glucose Oxidase