title: Variables that influence cellular uptake and cytotoxic/cytoprotective effects of macrocyclic iron complexes.
abstract: Determination of the cellular uptake of macrocyclic iron(III) complexes by a facile method, accompanied by cell viability tests under both basal and induced oxidative stress, demonstrates that protection against intracellular oxidative stress requires reasonably high internalization and favorable anti/prooxidant profiles. Of the four tested complexes, only amphipolar iron(III) corrole met these criteria.
authors.affiliation: Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Haber
authors.forename: Michael
authors.initials: M
authors.lastname: Aviram
authors.forename: Zeev
authors.initials: Z
authors.lastname: Gross
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects*; D003603:Cytotoxins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D003603:Cytotoxins; D005290:Ferric Compounds; D047028:Macrocyclic Compounds