title: Molecular programming of B cell memory.
abstract: The development of high-affinity B cell memory is regulated through three separable phases, each involving antigen recognition by specific B cells and cognate T helper cells. Initially, antigen-primed B cells require cognate T cell help to gain entry into the germinal centre pathway to memory. Once in the germinal centre, B cells with variant B cell receptors must access antigens and present them to germinal centre T helper cells to enter long-lived memory B cell compartments. Following antigen recall, memory B cells require T cell help to proliferate and differentiate into plasma cells. A recent surge of information - resulting from dynamic B cell imaging in vivo and the elucidation of T follicular helper cell programmes - has reshaped the conceptual landscape surrounding the generation of memory B cells. In this Review, we integrate this new information about each phase of antigen-specific B cell development to describe the newly unravelled molecular dynamics of memory B cell programming.
authors.affiliation: Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. mcheyzer@scripps.edu
authors.forename: Michael
authors.initials: M
authors.lastname: McHeyzer-Williams
authors.forename: Shinji
authors.initials: S
authors.lastname: Okitsu
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Wang
authors.forename: Louise
authors.initials: L
authors.lastname: McHeyzer-Williams
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018858:Germinal Center / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000941:Antigens