title: Evaluation of performance of quantiferon assay and tuberculin skin test in end stage renal disease patients receiving hemodialysis.
abstract: OBJECTIVE
  End stage renal disease (ESRD) cases are associated with increased risk of tuberculosis. There is no gold standard method for detecting latent tuberculosis infection (LTBI) in ESRD. The aim of the present study was to analyze the performance of the tuberculin skin test (TST) and QuantiFERON-TB Gold in tube (QFT-G) in cases receiving hemodialysis (HD).
  
  
  METHODS
  The TST and QFT-G were prospectively performed in 96 ESRD cases undergoing HD. The agreement of the QFT-G and TST was assessed in two TST cut off values (10 mm and 5 mm) in Bacille Calmette Guèrin (BCG) vaccinated and non-vaccinated cases.
  
  
  RESULTS
  Of 96 cases 67 were BCG vaccinated and 29 were BCG non-vaccinated. QFT-G was positive in 39.6% cases and indeterminate in 3.1%. TST was positive in 43.8% of cases in cut off value of 10 mm and positive in 58.3% of cases in cut off value of 5 mm. Agreement between TST and QFT-G results was fair in both BCG vaccinated and non-vaccinated cases in either cut off values, except in cut off value of 10 mm in BCG vaccinated cases in which the agreement was moderate.
  
  
  CONCLUSIONS
  The agreement between QFT-G and TST test is fair and there is no significant difference in both cut off values of TST in screening of LTBI in ESRD cases receiving HD.
authors.affiliation: Department of Pulmonary Medicine, Selcuk University, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Maden
authors.forename: Taha T
authors.initials: TT
authors.lastname: Bekci
authors.forename: Recep
authors.initials: R
authors.lastname: Kesli
authors.forename: Huseyin
authors.initials: H
authors.lastname: Atalay
authors.forename: Turgut
authors.initials: T
authors.lastname: Teke
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turk
authors.forename: Kursat
authors.initials: K
authors.lastname: Uzun
authors.forename: Ramazan
authors.initials: R
authors.lastname: Koylu
mesh_terms: D000328:Adult; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000592:standards; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012307:Risk Factors; D014374:Tuberculin Test / Q000379:methods* / Q000592:standards*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine