title: Use of quantitative HIV RNA detection for early diagnosis of HIV infection in infants and acute HIV infections in Alberta, Canada.
abstract: Quantitative HIV RNA viral load (QVL) assays (Roche Diagnostics) were sensitive and specific when used to diagnose HIV infection in (i) HIV-exposed infants (sensitivity of 100% [63.1 to 100%] and specificity of 100% [97.9 to 100%]) and (ii) suspected acute HIV infection patients with a negative/indeterminate Western blot (sensitivity of 97.6% [91.6 to 99.7%] and specificity of 100% [96.1 to 100%]). No false-positive QVL results were identified.
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. bonita.lee@albertahealthservices.ca
authors.forename: Bonita E
authors.initials: BE
authors.lastname: Lee
authors.forename: Sabrina S
authors.initials: SS
authors.lastname: Plitt
authors.forename: Gayatri C
authors.initials: GC
authors.lastname: Jayaraman
authors.forename: Linda
authors.initials: L
authors.lastname: Chui
authors.forename: Ameeta E
authors.initials: AE
authors.lastname: Singh
authors.forename: Jutta K
authors.initials: JK
authors.lastname: Preiksaitis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000416:Alberta; D002675:Child, Preschool; D003951:Diagnostic Errors / Q000706:statistics & numerical data; D042241:Early Diagnosis; D005260:Female; D015658:HIV Infections / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics; D012680:Sensitivity and Specificity; D019562:Viral Load / Q000379:methods*; D055815:Young Adult
chemical_list: D012367:RNA, Viral