title: HLA associations and Löfgren's syndrome.
abstract: Patients with sarcoidosis can be subgrouped according to organ engagement and clinical manifestations. One such subgroup is Löfgren's syndrome (LS), constituting a distinct group of sarcoidosis patients with typical clinical manifestations, separate genetic associations and an immune response that seems to differ from that of non-LS patients. In particular, LS patients have strong associations with HLA-DRB1 alleles, and the well-known association with HLA-DRB1*03 is particularly striking. This particular HLA-DRB1 allele is also a very strong marker within that particular group of patients for a prognostically favorable disease course. This article will mainly discuss genetic associations with LS, and the possible implications of such associations.
authors.affiliation: Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Lung Research Laboratory L4:01, Karolinska University Hospital Solna, S-171 76 Stockholm, Sweden. johan.grunewald@ki.se
authors.forename: Johan
authors.initials: J
authors.lastname: Grunewald
mesh_terms: D000483:Alleles; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006801:Humans; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology
chemical_list: D005819:Genetic Markers; D059811:HLA-DRB1 Chains