title: A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer's Disease with or without Diabetes.
abstract: OBJECTIVE
  To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer's disease (AD).
  
  
  METHODS
  We investigated the initial rCBF of 71 AD patients (36 without DM and 35 with DM) and the final rCBF of 23 AD patients (12 without DM and 11 with DM) after an average of 32 months. Single-photon emission computed tomography (SPECT) data were analyzed by statistical brain imaging.
  
  
  RESULTS
  The initial SPECT showed that AD patients without DM had lower rCBF in the left and right inferior temporal gyri than AD patients with DM. A follow-up SPECT demonstrated that rCBF decreased in more widespread regions, including the parietal, temporal, frontal, and limbic lobes, in AD patients without than with DM.
  
  
  CONCLUSIONS
  This study suggests that functional brain abnormalities in AD differ depending on the DM status at baseline and during follow-up, reflecting neuropathologic differences.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hirao
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sato
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kanetaka
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sakurai
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iwamoto