title: Asymptomatic oral human papillomavirus (HPV) infection in women with a histopathologic diagnosis of genital HPV.
abstract: The oral route of human papillomavirus (HPV) transmission is not fully understood. It has been suggested that genital infection can act as a reservoir for oral HPV infection. We investigated the presence of oral HPV DNA and anti-HPV IgA in the buccal cavity of patients with a histopathologic diagnosis of cervical HPV infection. One hundred women underwent oral clinical examinations to detect HPV-DNA by polymerase chain reaction and salivary anti-HPV IgA by indirect immunofluorescence. Information on the personal habits of all the women was collected in personal interviews. Our results showed that 99% of the patients had no clinical manifestations of oral HPV. However, HPV DNA was detected in 81% of oral mucosa samples, and anti-HPV IgA was detected in the saliva of 44% of the patients. Consumption of alcoholic beverages was significantly associated with detection of oral HPV DNA and salivary anti-HPV IgA. Other behavioral risk factors associated with oral HPV and anti-HPV IgA are also discussed. In conclusion, patients with genital HPV infection are at risk for subclinical oral HPV infection. Thus, a molecular assay might be necessary to diagnose such infections.
authors.affiliation: Laboratory of Virology, Department of Biointeraction, Institute of Health Sciences, Federal University of Bahia, Vale do Canela, Brazil.
authors.forename: Andrea P
authors.initials: AP
authors.lastname: Peixoto
authors.forename: Gubio S
authors.initials: GS
authors.lastname: Campos
authors.forename: Leila B
authors.initials: LB
authors.lastname: Queiroz
authors.forename: Silvia I
authors.initials: SI
authors.lastname: Sardi
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000032:analysis / Q000235:genetics; D058345:Asymptomatic Infections; D016009:Chi-Square Distribution; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D009059:Mouth Diseases / Q000821:virology*; D009061:Mouth Mucosa / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000635:transmission / Q000821:virology*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012463:Saliva / Q000276:immunology; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000821:virology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral