title: Linear immunoglobulin A bullous dermatosis.
abstract: Linear immunoglobulin A (IgA) bullous dermatosis, also known as linear IgA disease, is an autoimmune mucocutaneous disorder characterized by subepithelial bullae, with IgA autoantibodies directed against several different antigens in the basement membrane zone. Its immunopathologic characteristic resides in the presence of a continuous linear IgA deposit along the basement membrane zone, which is clearly visible on direct immunofluorescence. This disorder shows different clinical features and distribution when adult-onset of linear IgA disease is compared with childhood-onset. Diagnosis is achieved via clinical, histopathologic, and immunopathologic examinations. Two common therapies are dapsone and sulfapyridine, which reduce the inflammatory response and achieve disease remission in a variable period of time.
authors.affiliation: Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, CA 94305, USA.
authors.forename: Giulio
authors.initials: G
authors.lastname: Fortuna
authors.forename: M Peter
authors.initials: MP
authors.lastname: Marinkovich
mesh_terms: D000328:Adult; D017668:Age of Onset; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D001485:Basement Membrane / Q000276:immunology; D002648:Child; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D001323:Autoantibodies; D007070:Immunoglobulin A