title: Ultrasound-assisted synthesis of novel α-aminophosphonates and their biological activity.
abstract: The synthesis of a series of novel α-aminosubstituted phosphonates was accomplished by the reaction of various substituted aldehydes with an amine amlodipine (3-ethyl 5-methyl (±)2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridene-3,5-dicarboxylate) followed by diethylphosphite/dibutylphosphite in ethanol using SnCl(2).2H(2)O as a Lewis acid catalyst, under conventional and ultrasonic irradiation. Their structures were established by analytical and spectral data. The title compounds showed good antibacterial, antifungal and antiviral activity depending on the nature of the bioactive groups at the α-carbon.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, India.
authors.forename: Syed
authors.initials: S
authors.lastname: Rasheed
authors.forename: Katla
authors.initials: K
authors.lastname: Venkataramana
authors.forename: Kuruva
authors.initials: K
authors.lastname: Chandrasekhar
authors.forename: Gemmalamadugu
authors.initials: G
authors.lastname: Fareeda
authors.forename: Chamarthi Naga
authors.initials: CN
authors.lastname: Raju
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000706:statistics & numerical data; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013016:Sound; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D063065:Organophosphonates