title: Intraventricular glioneuronal tumor with disseminated lesions at diagnosis--a case report.
abstract: A 55-year-old man presented with a large tumor in his lateral ventricles. Magnetic resonance imaging revealed disseminated lesions in the third and fourth ventricles at the time of diagnosis. The patient underwent a partial removal of the tumor in the lateral ventricles. Histologically, the surgical specimens showed glioneuronal differentiation with ganglion or ganglioid cells, Rosenthal fibers, oligodendroglia-like honeycomb appearances, a spongy pattern, perivascular pseudorosettes, and many hyalinized blood vessels. Papillary structure was not observed. The neuronal component showed a moderately high labeling index of Ki-67/MIB-1. We diagnosed this tumor as atypical intraventricular glioneuronal tumor. The disseminated lesions disappeared after chemoradiation therapy with temozolomide, and the residual tumors in the lateral ventricles remained stable for 3 years after the surgery. We discuss the pathological diagnosis, therapy and clinical course with review of the literatures.
authors.affiliation: Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan. hirohito@gifu-u.ac.jp
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yano
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nakayama
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ohe
authors.forename: Jun
authors.initials: J
authors.lastname: Shinoda
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yoshimura
authors.forename: Toru
authors.initials: T
authors.lastname: Iwama
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D002552:Cerebral Ventricles / Q000473:pathology*; D059186:Chemoradiotherapy, Adjuvant; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018303:Ganglioglioma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D050397:Radiotherapy, Intensity-Modulated; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D003606:Dacarbazine; D000077204:Temozolomide