title: Heartworm genomics: unprecedented opportunities for fundamental molecular insights and new intervention strategies.
abstract: Vector-borne diseases, including canine heartworm disease (CHWD), are of major socioeconomic and canine health importance worldwide. Although many studies have provided insights into CHWD, to date there has been limited study of fundamental molecular aspects of Dirofilaria immitis itself, its relationship with the canine host, its vectors, as well as the potential of drug resistance to emerge, using advanced -omic technologies. This article takes a prospective view of the benefits that advanced -omics technologies will have toward understanding D. immitis and CHWD. Tackling key biological questions using these technologies will provide a "systems biology" context and could lead to radically new intervention and management strategies against heartworm.
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. robinbg@unimelb.edu.au
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
authors.forename: Cinzia
authors.initials: C
authors.lastname: Cantacessi
mesh_terms: D000818:Animals; D004183:Dirofilaria immitis / Q000235:genetics*; D004184:Dirofilariasis / Q000469:parasitology / Q000517:prevention & control*; D004283:Dog Diseases / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D023281:Genomics; D008967:Molecular Biology; D014158:Transcription, Genetic