title: Trichomonas vaginalis pathobiology new insights from the genome sequence.
abstract: The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hirt
authors.forename: Natalia
authors.initials: N
authors.lastname: de Miguel
authors.forename: Sirintra
authors.initials: S
authors.lastname: Nakjang
authors.forename: Daniele
authors.initials: D
authors.lastname: Dessi
authors.forename: Yuk-Chien
authors.initials: YC
authors.lastname: Liu
authors.forename: Nicia
authors.initials: N
authors.lastname: Diaz
authors.forename: Paola
authors.initials: P
authors.lastname: Rappelli
authors.forename: Alvaro
authors.initials: A
authors.lastname: Acosta-Serrano
authors.forename: Pier-Luigi
authors.initials: PL
authors.lastname: Fiori
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Mottram
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018503:Genome, Protozoan; D006801:Humans; D008969:Molecular Sequence Data; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D014245:Trichomonas Infections / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*
chemical_list: D020543:Proteome; D015800:Protozoan Proteins