title: Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer.
abstract: We elucidated the relationship between prognosis of non-small-cell lung cancer (NSCLC) and Wilms' tumor gene (WT1) mRNA expression in tumor tissue. The WT1 mRNA expression levels of the fatal cases were lower as compared with those of the survival cases. Overall survival (OS) and disease-free survival (DFS) of the high WT1 expression group were longer than of the low expression group. As for squamous cell lung cancer (SQLC), low WT1 expression was significantly associated with lymph node metastasis. Cox analysis revealed that the gene level was a significant prognostic factor in OS and DFS. Low WT1 expression predicted poor prognosis in patients with NSCLC.
authors.affiliation: Department of Internal Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, Osaka, Japan. shayashi@kch.hosp.go.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Oji
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kanai
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Teramoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitaichi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Masaji
authors.initials: M
authors.lastname: Okada
authors.forename: Haruo
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Akihide
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D016162:Genes, Wilms Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D025721:WT1 Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D025721:WT1 Proteins