title: Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats.
abstract: Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco 44340, Mexico.
authors.forename: Ignacio
authors.initials: I
authors.lastname: González-Burgos
authors.forename: Martha C
authors.initials: MC
authors.lastname: Rivera-Cervantes
authors.forename: Dulce A
authors.initials: DA
authors.lastname: Velázquez-Zamora
authors.forename: Alfredo
authors.initials: A
authors.lastname: Feria-Velasco
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Garcia-Segura
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D049229:Dendritic Spines / Q000187:drug effects* / Q000648:ultrastructure; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000502:physiology; D020849:Raloxifene Hydrochloride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology
chemical_list: D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride