title: Inhibitory activity of Fe(3) O(4)/oleic acid/usnic acid-core/shell/extra-shell nanofluid on S. aureus biofilm development.
abstract: Undesired biofilm development is a major concern in many areas, especially in the medical field. The purpose of the present study was to comparatively investigate the antibiofilm efficacy of usnic acid, in soluble versus nanofluid formulation, in order to highlight the potential use of  Fe(3) O(4)/oleic  acid (FeOA) nanofluid as potential controlled release vehicle of this antibiofilm agent. The  (+) -UA loaded into nanofluid exhibited an improved antibiofilm effect on S. aureus biofilm formation, revealed by the drastic decrease of the viable cell counts as well as by confocal laser scanning microscopy images. Our results demonstrate that FeOA nanoparticles could be used as successful coating agents for obtaining antibiofilm pellicles on different medical devices, opening a new perspective for obtaining new antimicrobial and antibiofilm surfaces, based on hybrid functionalized nanostructured biomaterials.
authors.affiliation: Science and Engineering of Oxidic Materialsand Nanomaterials, University Politehnica of Bucharest, Romania. grumezescu@yahoo.com
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Crina
authors.initials: C
authors.lastname: Saviuc
authors.forename: Mariana Carmen
authors.initials: MC
authors.lastname: Chifiriuc
authors.forename: Radu
authors.initials: R
authors.lastname: Hristu
authors.forename: Dan Eduard
authors.initials: DE
authors.lastname: Mihaiescu
authors.forename: Paul
authors.initials: P
authors.lastname: Balaure
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Stanciu
authors.forename: Veronica
authors.initials: V
authors.lastname: Lazar
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D001672:Biocompatible Materials; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development*; D052203:Ferrosoferric Oxide / Q000494:pharmacology*; D018613:Microscopy, Confocal; D058726:Nanoconjugates; D053758:Nanoparticles; D019301:Oleic Acid / Q000494:pharmacology; D009829:Oleic Acids / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D001572:Benzofurans; D001672:Biocompatible Materials; D058726:Nanoconjugates; D009829:Oleic Acids; C073339:usnic acid; D019301:Oleic Acid; D052203:Ferrosoferric Oxide