title: Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants.
abstract: OBJECTIVE
  Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest.
  
  
  METHODS
  Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography. BP was recorded during quiet (QS) and active (AS) sleep using a photoplethysmographic cuff placed around the infant's wrist (Finometer [FMS, Finapres Medical Systems, Amsterdam, Netherlands]). BRS (milliseconds/mm Hg) was assessed in 1- to 2-minute epochs using cross-spectral analysis.
  
  
  RESULTS
  In preterm infants, postnatal age had no significant effect on BRS within either QS or AS. This was in contrast to the maturational increase in QS observed in term infants. Compared with term infants, BRS of preterm infants was 38% higher at 2 to 4 weeks CA and 29% lower at 5 to 6 months CA during QS (P <.05). Comparing sleep states, BRS of preterm infants was 26% lower in QS compared with AS at 2 to 3 months CA (P <.05).
  
  
  CONCLUSIONS
  Preterm birth impairs the normal maturational increase in BRS, resulting in a substantial reduction in BRS at 5 to 6 months CA during QS. Lower BRS during QS compared with AS at 2 to 3 months CA may place preterm infants at an increased risk for cardiovascular instability at this age of peak incidence of SIDS.
authors.affiliation: The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.
authors.forename: Nicole B
authors.initials: NB
authors.lastname: Witcombe
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Yiallourou
authors.forename: Scott A
authors.initials: SA
authors.lastname: Sands
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Walker
authors.forename: Rosemary S C
authors.initials: RS
authors.lastname: Horne
mesh_terms: D017704:Baroreflex; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology; D008297:Male; D017286:Polysomnography; D047928:Premature Birth; D012890:Sleep / Q000502:physiology*; D013398:Sudden Infant Death / Q000209:etiology