title: Imaging of hemorrhagic fever with renal syndrome: a potential bioterrorism agent of military significance.
abstract: Hemorrhagic fever with renal syndrome (HFRS) is a potentially fatal infectious disease with worldwide distribution. Its etiologic agents are viruses of the genus Hantavirus of the virus family Bunyaviridae. Hypothetical ease of production and distribution of these agents, with their propensity to incapacitate victims and overwhelm health care resources, lend themselves as significant potential biological agents of terrorism. HFRS has protean clinical manifestations, which may mimic upper respiratory tract infection, nephrolithiasis, and Hantavirus pulmonary syndrome and may delay proper treatment. Sequelae of HFRS, such as hemorrhage, acute renal failure, retroperitoneal edema, pancreatitis, pulmonary edema, and neurologic symptoms, can be detected by different imaging modalities. Medical providers caring for HFRS patients must be aware of its radiologic features, which may help to confirm its clinical diagnosis. In this article, the authors review the epidemiology, pathophysiology, clinical presentation, diagnosis, treatment, and complications of HFRS.
authors.affiliation: Department of Radiology, Brook Army Medical Center, 3851 Rodger Brook Drive, Fort Sam Houston, TX 78234, USA.
authors.forename: Liem T
authors.initials: LT
authors.lastname: Bui-Mansfield
authors.forename: Dana K
authors.initials: DK
authors.lastname: Cressler
mesh_terms: D058186:Acute Kidney Injury / Q000821:virology; D023482:Bioterrorism; D003937:Diagnosis, Differential; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008887:Military Medicine; D053040:Nephrolithiasis / Q000175:diagnosis; D012141:Respiratory Tract Infections / Q000175:diagnosis; D014057:Tomography, X-Ray Computed