title: [Features of intestine microbiocenosis and systemic inflammation factors in chronic heart failure patients].
abstract: OBJECTIVE
  Intestine microbiocenosis structure, endotoxinemia level, C-reactive protein (CRP) and TNFalpha concentration in chronic heart failure patients (CHF) were studied depending on disease severity.
  
  
  METHODS
  Clinical, echocardiographic and laboratory examination of 104 patients was performed: 75 CHF patients and 29 healthy volunteers. Laboratory examination included bacteriologic analysis of feces for dysbiosis, determination of endotoxin (ET) levels, CRP and TNFalpha levels in blood serum.
  
  
  RESULTS
  More expressed alterations in large intestine microbiocenosis and an increase of endotoxinemia and systemic inflammation factors (TNFalpha and CRP) levels were detected in patients with CHF in comparison to individuals without circulatory system pathology. CHF progression is associated with an increase of intestine dysbiosis, and ET, TNFalpha and CRP levels in blood.
  
  
  CONCLUSIONS
  Endotoxinemia in CHF patients, that is caused by an increase in intestine wall permeability during development of venous congestion in systemic circulation, results in immune system activation manifesting in an increase of systemic inflammation factor level in blood that can aggravate the CHF course.
authors.forename: E N
authors.initials: EN
authors.lastname: Egorova
authors.forename: S I
authors.initials: SI
authors.lastname: Sergeeva
authors.forename: V V
authors.initials: VV
authors.lastname: Mazur
authors.forename: M N
authors.initials: MN
authors.lastname: Kalinkin
authors.forename: E S
authors.initials: ES
authors.lastname: Mazur
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D019446:Endotoxemia / Q000097:blood / Q000150:complications / Q000382:microbiology*; D004731:Endotoxins / Q000097:blood; D004755:Enterobacteriaceae / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification / Q000472:pathogenicity; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000382:microbiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000382:microbiology*; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein