title: Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery.
abstract: Tropicamide-loaded carboxymethyl tamarind kernel polysaccharide (CMTKP) nanoparticles were prepared and evaluated for ocular delivery. Preparation of ionotropically gelled CMTKP nanoparticles was optimized employing three-levels, two-factor central composite design. Concentration of polymer and crosslinker had significant synergistic effect on particle size and % encapsulation efficiency. The optimal calculated parameters were concentrations of CMTKP 0.10% (w/v) and calcium chloride 0.11% (w/v). The optimized tropicamide-loaded CMTKP formulation showed ex vivo corneal permeation of tropicamide across isolated goat cornea comparable to its aqueous solution. Further, the mucoadhesive and non-irritant nature of CMTKP nanoparticles indicate their suitability as ocular delivery system.
authors.affiliation: Nanomaterials Synthesis & Characterization Laboratory, Department of Bio & Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar 125001, India.
authors.forename: Harmanmeet
authors.initials: H
authors.lastname: Kaur
authors.forename: Munish
authors.initials: M
authors.lastname: Ahuja
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dilbaghi
mesh_terms: D000327:Adsorption; D000818:Animals; D002122:Calcium Chloride / Q000737:chemistry; D049033:Chorioallantoic Membrane / Q000187:drug effects; D003315:Cornea / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D009077:Mucins / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011134:Polysaccharides / Q000737:chemistry*; D029861:Tamarindus / Q000737:chemistry*; D014331:Tropicamide / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D009077:Mucins; D011134:Polysaccharides; D002122:Calcium Chloride; D014331:Tropicamide