title: Combined therapy of voriconazole and anidulafungin in murine infections by Aspergillus flavus.
abstract: The efficacy of the combination of anidulafungin (AFG) at 1 mg/kg plus voriconazole (VRC) at 25 mg/kg was evaluated in a murine model of disseminated infection by Aspergillus flavus using three isolates previously tested in vitro. All the combinations showed indifferent in vitro interaction with the exception of one, which showed synergy. In general, the combined treatment prolonged the survival and reduced the fungal load in comparison with AFG alone, and only in a few cases, it improved the results of the VRC monotherapy. The combination of the two drugs and VRC alone reduced the galactomannan levels in serum in comparison with the control group.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, Reus, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Valentina
authors.initials: V
authors.lastname: Salas
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001231:Aspergillus flavus / Q000187:drug effects* / Q000502:physiology; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000008:administration & dosage*; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D011743:Pyrimidines; D014230:Triazoles; D000077612:Anidulafungin; D065819:Voriconazole