title: Spectroscopic evidence for the unusual stereochemical configuration of an endosome-specific lipid.
abstract: At a glance: The stereochemical configuration of the diglycerophosphate backbone of the endosome-specific lipid bis(monoacylglycero)phosphate (BMP, see picture) was determined by (1)H NMR spectroscopy. Enantiomeric discrimination was facilitated by introduction of D-camphor ketals as chiral shift reagents, and enantiopure synthetic BMP analogues were prepared as reference materials. Natural BMP exhibited the unusual sn-1,1' diglycerophosphate backbone.
authors.affiliation: Lipid Biology Laboratory, ASI RIKEN, 351-0198, Japan.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Tan
authors.forename: Asami
authors.initials: A
authors.lastname: Makino
authors.forename: Kumar
authors.initials: K
authors.lastname: Sudesh
authors.forename: Peter
authors.initials: P
authors.lastname: Greimel
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D011992:Endosomes / Q000737:chemistry*; D008246:Lysophospholipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D050178:Monoglycerides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008246:Lysophospholipids; D050178:Monoglycerides; C012786:bis(monoacylglyceryl)phosphate