title: Overexpression of SGLT1 is correlated with tumor development and poor prognosis of ovarian carcinoma.
abstract: OBJECTIVE
  Overexpression of glucose transporters has been identified in a variety of human cancers. However, the expression status of Sodium dependent Glucose Transporter 1 (SGLT1) in ovarian carcinoma has not been investigated.
  
  
  METHODS
  In our study, protein expression levels of SGLT1 were explored by semiquantitative immunohistochemical staining on archival formalin-fixed paraffin-embedded pathologic specimen consisting of 178 epithelial ovarian tumors. Receiver operating characteristic curve analysis, Spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were utilized to analyze the data.
  
  
  RESULTS
  The threshold for high expression of SGLT1 was determined to be above 40% (areas under curve = 0.683, P = 0.003) based on the area under curves. Significantly overexpression of SGLT1 was observed in 39.7% invasive carcinomas, 11.5% borderline tumors, 10% cystadenomas but in none of the normal ovaries (0%). In ovarian carcinomas, SGLT1 overexpression was positively correlated with later pT status (P = 0.029) and advanced FIGO stage (P = 0.024). By univariate survival analysis on the ovarian carcinoma cohorts, overexpression of SGLT1 was associated with shortened patient survival (mean 70.5 months in tumors with overexpression of SGLT1 versus 89.3 months in tumors with normal levels of SGLT1; P = 0.019). By multivariate analysis, SGLT1 protein expression remained as a significant and independent prognostic factor for the prediction of patient survival (P = 0.033).
  
  
  CONCLUSIONS
  SGLT1 overexpression, as examined by immunohistochemistry, is an independent biomarker for poor prognosis of patients with ovarian carcinoma.
authors.affiliation: Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Bingquan
authors.initials: B
authors.lastname: Lai
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hongwei
authors.initials: H
authors.lastname: Pu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Cao
authors.forename: Hualan
authors.initials: H
authors.lastname: Jing
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D051269:Sodium-Glucose Transporter 1 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C495674:SLC5A1 protein, human; D051269:Sodium-Glucose Transporter 1