title: Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet.
abstract: We have previously demonstrated that coffee and caffeine ameliorated hyperglycemia in spontaneously diabetic KK-A(y) mice. This present study evaluates the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet were given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. The ingestion of coffee or caffeine improved glucose tolerance, insulin sensitivity, and hyperinsulinemia when compared with mice in the control group. The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group. These results suggest that coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance by improving insulin sensitivity. This effect might be attributable in part to the reduction of inflammatory adipocytokine expression.
authors.affiliation: Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Misato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Rie
authors.initials: R
authors.lastname: Yamauchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
authors.forename: Masanori
authors.initials: M
authors.lastname: Hiramitsu
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Takao
authors.initials: T
authors.lastname: Katagiri
authors.forename: Atsushi
authors.initials: A
authors.lastname: Murai
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Horio
mesh_terms: D054392:Adipokines / Q000235:genetics; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002110:Caffeine / Q000494:pharmacology*; D003069:Coffee; D059305:Diet, High-Fat / Q000009:adverse effects*; D004435:Eating; D005227:Fatty Acids / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000187:drug effects; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D003069:Coffee; D005227:Fatty Acids; D007004:Hypoglycemic Agents; D007328:Insulin; D012333:RNA, Messenger; D002110:Caffeine