title: Microdrop printing of hydrogel bioinks into 3D tissue-like geometries.
abstract: An optimized 3D inkjet printing process is demonstrated for structuring alginate into a tissue-like microvasculature capable of supporting physiological flow rates. Optimizing the reaction at the single-droplet level enables wet hydrogel droplets to be stacked, thus overcoming their natural tendancy to spread and coalesce. Live cells can be patterned using this process and it can be extended to a range of other hydrogels.
authors.affiliation: Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Switzerland.
authors.forename: Kris
authors.initials: K
authors.lastname: Pataky
authors.forename: Thomas
authors.initials: T
authors.lastname: Braschler
authors.forename: Andrea
authors.initials: A
authors.lastname: Negro
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
authors.forename: Matthias P
authors.initials: MP
authors.lastname: Lutolf
authors.forename: Juergen
authors.initials: J
authors.lastname: Brugger
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D032701:Biomimetics / Q000379:methods*; D003094:Collagen / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057446:Hydrodynamics; D020100:Hydrogels; D007281:Ink; D051379:Mice; D055616:Microtechnology / Q000379:methods*; D041681:NIH 3T3 Cells; D011327:Printing / Q000379:methods*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D005780:Gelatin; D003094:Collagen