title: Is serum placental growth factor a prognostic marker for stage III colorectal cancer patients?
abstract: OBJECTIVE
  To evaluate the clinical usefulness of serum placental growth factor (sPIGF) levels in stage III colorectal adenocarcinomas (CRC).
  
  
  METHODS
  Serum PIGF were measured in 70 healthy controls and in 80 stage III CRC patients. Also the association between preoperative sPGF levels, clinicopathological features and patients survival were evaluated in stage III CRC patients.
  
  
  RESULTS
  sPIGF levels in stage III CRC patients were significantly higher than those in controls. There was no significant association between sPIGF levels and clinicopathological features and sPIGF is not a prognostic factor for survival. Multivariate regression analysis showed the sPIGF levels (hazard ratio=3.28; 95% CI=1.10-9.5, p=0.032) to be significant independent factors for local recurrence.
  
  
  CONCLUSIONS
  Serum PIGF levels in stage III CRC patients are significantly higher compared with normal controls and may be an indicator of local recurrence in stage III CRC patients.
authors.affiliation: Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Gomceli
authors.forename: Mesut
authors.initials: M
authors.lastname: Tez
authors.forename: Erdal B
authors.initials: EB
authors.lastname: Bostanci
authors.forename: Murat
authors.initials: M
authors.lastname: Ulas
authors.forename: Nesrin
authors.initials: N
authors.lastname: Turhan
authors.forename: Ahu S
authors.initials: AS
authors.lastname: Kemik
authors.forename: Musa
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D009367:Neoplasm Staging; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood*; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric
chemical_list: D014408:Biomarkers, Tumor; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor