title: Total synthesis of camptothecin and SN-38.
abstract: A new practical and concise total synthesis of enantiopure camptothecin and SN-38 (14% overall yield, 99.9% ee and 99.9% purity) was described, starting from inexpensive and readily available materials. The development of column chromatography-free purification was achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.
authors.affiliation: Institute of Drug Discovery and Development, iAIR, Shanghai 200062, China.
authors.forename: Shanbao
authors.initials: S
authors.lastname: Yu
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000077146:Irinotecan; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000077146:Irinotecan; D002166:Camptothecin