title: Evaluation of Fujinon intelligent chromo endoscopy-assisted capsule endoscopy in patients with obscure gastroenterology bleeding.
abstract: OBJECTIVE
  To investigate the potential benefit of Fujinon intelligent chromo endoscopy (FICE)-assisted small bowel capsule endoscopy (SBCE) for detection and characterization of small bowel lesions in patients with obscure gastroenterology bleeding (OGIB).
  
  
  METHODS
  The SBCE examinations (Pillcam SB2, Given Imaging Ltd) were retrospectively analyzed by two GI fellows (observers) with and without FICE enhancement. Randomization was such that a fellow did not assess the same examination with and without FICE enhancement. The senior consultant described findings as P0, P1 and P2 lesions (non-pathological, intermediate bleed potential, high bleed potential), which were considered as reference findings.
  
  
  METHODS
  Inter-observer correlation was calculated using kappa statistics. Sensitivity and specificity for P2 lesions was calculated for FICE and white light SBCE.
  
  
  RESULTS
  In 60 patients, the intra-class kappa correlations between the observers and reference findings were 0.88 and 0.92 (P2), 0.61 and 0.79 (P1), for SBCE using FICE and white light, respectively. Overall 157 lesions were diagnosed using FICE as compared to 114 with white light SBCE (P = 0.15). For P2 lesions, the sensitivity was 94% vs 97% and specificity was 95% vs 96% for FICE and white light, respectively. Five (P2 lesions) out of 55 arterio-venous malformations could be better characterized by FICE as compared to white light SBCE. Significantly more P0 lesions were diagnosed when FICE was used as compared to white light (39 vs 8, P < 0.001).
  
  
  CONCLUSIONS
  FICE was not better than white light for diagnosing and characterizing significant lesions on SBCE for OGIB. FICE detected significantly more non-pathological lesions. Nevertheless, some vascular lesions could be more accurately characterized with FICE as compared to white light SBCE.
authors.affiliation: Department of Hepato-Gastroenterology, Erasme Hospital-Free University of Brussels, Route de Lennik, 808, 1070 Brussels, Belgium.
authors.forename: Tarun
authors.initials: T
authors.lastname: Gupta
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Jacques
authors.initials: J
authors.lastname: Deviere
authors.forename: André
authors.initials: A
authors.lastname: Van Gossum
mesh_terms: D053704:Capsule Endoscopy / Q000295:instrumentation* / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007421:Intestine, Small / Q000473:pathology*; D008027:Light; D012189:Retrospective Studies; D012680:Sensitivity and Specificity