title: Relationship between adiponectin and testosterone in patients with type 2 diabetes.
abstract: BACKGROUND
  This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes.
  
  
  METHODS
  Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05, P = 0.167).
  
  
  CONCLUSIONS
  We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics.
authors.affiliation: Department of Endocrinology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Gui-Fen
authors.initials: GF
authors.lastname: Niu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Bai
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xu
authors.forename: Guang-Zhen
authors.initials: GZ
authors.lastname: Zhang
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood*
chemical_list: D052242:Adiponectin; D013739:Testosterone