title: Analysis of ABC (D) stratification for screening patients with gastric cancer.
abstract: OBJECTIVE
  To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer.
  
  
  METHODS
  Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylori antibody levels were measured. Patients were classified into five groups of ABC (D) stratification according to their serological status. Endoscopic findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC (D) stratification.
  
  
  RESULTS
  The mean patient age was (67.9 ± 8.9) years. Three patients (3.2%) were classified into group A, 7 patients (7.4%) into group A', 27 patients (28.4%) into group B, 54 patients (56.8%) into group C, and 4 patients (4.2%) into group D, respectively. There were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for H. pylori (group A') were excluded. These three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC (D) stratification. Histologically, the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma (P < 0.05). There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated groups.
  
  
  CONCLUSIONS
  ABC (D) stratification is a good method for screening patients with gastric cancers. Endoscopy is needed for grey zone cases to check the extent of mucosal atrophy.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kudo
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.forename: Naondo
authors.initials: N
authors.lastname: Sohara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Onozato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Okamura
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Inui
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood / Q000145:classification* / Q000175:diagnosis / Q000473:pathology*
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D020115:Pepsinogen C; D020116:Pepsinogen A