title: Efficacy of two different CHX-containing desensitizers: a controlled double-blind study.
abstract: The aim of this study was to compare the effectiveness and duration of action of the tooth desensitization agent Cervitec (C) vs that of the new Cervitec Plus (C+). In this monocentric, single-center, three-armed, controlled, double-blind study, 120 subjects were randomly assigned to one of three groups:group I received Cervitec Plus (C+), group II received Cervitec (C), and group III received placebo (P). Varnishes were applied after base-line determination of cervical dentin hyper-sensitivity using a pain score of one or higher.Re-evaluation was performed 1, 7, 30, and 90 days after application. Statistical evaluation was carried out using nonparametric statistics for relative effects and analysis of variance(ANOVA). Thirty days after application of Cand C+, all hypersensitivity decreased significantly in relation to baseline measurements(p<0.001), with no changes taking place in the placebo group. Significant differences were observed between C and C+ vs placebo(p<0.001), whereas no significant difference between C and C+ was seen after 30 days(p=0.840). After 90 days, the reduction in hypersensitivity with C+ was still significant compared with baseline measurements(p=0.001). However, C was not significantly different compared with baseline measurements (p=0.05). Analysis of all hypersensitive posterior teeth examined showed no significant difference between C and C+ after 90 days(p=0.362). For anterior teeth, the difference between C and C+ was significant (p=0.012).Both C and C+ reduce cervical tooth hypersensitivity, whereas C+ reduces hypersensitivity for a longer period of time.
authors.affiliation: Department of Preventive Dentistry, University of Goettingen, Germany. steffi.drebenstedt@med.uni-goettingen.de
authors.forename: S
authors.initials: S
authors.lastname: Drebenstedt
authors.forename: A
authors.initials: A
authors.lastname: Zapf
authors.forename: T
authors.initials: T
authors.lastname: Rödig
authors.forename: R F
authors.initials: RF
authors.lastname: Mausberg
authors.forename: D
authors.initials: D
authors.lastname: Ziebolz
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000517:prevention & control; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010919:Placebos; D011145:Polyvinyls / Q000627:therapeutic use; D013943:Thymol / Q000627:therapeutic use; D019237:Tooth Cervix / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D057133:Dentin Desensitizing Agents; D004338:Drug Combinations; D010919:Placebos; D011145:Polyvinyls; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; C003080:poly(vinyl chloride)-poly(vinyl acetate) copolymer; D002710:Chlorhexidine