title: Synthesis of highly functionalized chiral 3,3'-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates.
abstract: An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads to synthetically interesting densely functionalized 3,3'-disubstituted oxindoles with creation of up to three stereogenic centers.
authors.affiliation: Department of Pharmaceutical Science, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Deyan
authors.initials: D
authors.lastname: Wu
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
authors.forename: Tengfei
authors.initials: T
authors.lastname: Li
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.forename: Sinan
authors.initials: S
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D000473:Alkanes; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; C030374:indole; D009584:Nitrogen; C007170:cyanoacetic acid