title: Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives.
abstract: The first nickel-catalyzed C-H bond arylation of azoles with phenol derivatives is described. The new Ni(cod)(2)/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. With this C-H/C-O biaryl coupling, we synthesized a series of privileged 2-arylazoles, including biologically active alkaloids. Moreover, we demonstrated the utility of the present reaction for functionalizing estrone and quinine.
authors.affiliation: Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Muto
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yamaguchi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Itami