title: Case in which tranilast ophthalmic solution was thought to be effective for the prevention of symblepharon and recurrence after pterygium surgery.
abstract: We report our experience of a case in which a combination of conjunctival symblepharon detachment, conjunctival granuloma excision, and conjunctival free flap transplantation was performed for the treatment of symblepharon after pterygium surgery, with satisfactory outcomes.   The patient was referred to our hospital with pterygium recurrence, symblepharon and granuloma formation after pterygium surgery in the right eye at another hospital. We performed conjunctival symblepharon detachment along with conjunctival autograft transplantation, and started instillation of tranilast ophthalmic solution immediately after the surgery, to inhibit proliferation and adhesion formation. During the 6 months' follow-up of the patient at our hospital, the postoperative course was satisfactory, and no recurrence of symblepharon, pterygium or granuloma was observed. There were no adverse drug reactions associated with the instillation of tranilast ophthalmic solution.   Tranilast ophthalmic solution may be effective not only for prevention of pterygium recurrence, but also for inhibition of symblepharon and granuloma formation.
authors.affiliation: Department of Ophthalmology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. ta41626@tsc.u-tokai.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuji
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawai
authors.forename: Haiyan
authors.initials: H
authors.lastname: Fan
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D003228:Conjunctiva / Q000637:transplantation; D003229:Conjunctival Diseases / Q000517:prevention & control* / Q000601:surgery*; D006099:Granuloma / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011625:Pterygium / Q000517:prevention & control* / Q000601:surgery*; D055502:Secondary Prevention; D016896:Treatment Outcome; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
chemical_list: D009883:Ophthalmic Solutions; D062367:ortho-Aminobenzoates; C012293:tranilast