title: [Bringing evidence to practice: obstacles and barriers].
abstract: Translating clinical research findings into daily medical practice is a complex procedure and subject to multiple impacts. Studies sponsored by drug manufacturers produce positive results more frequently than would be expected by chance alone; positive studies have a better chance to be published than negative ones. There is a lack of effective implementation strategies for medical guidelines. The mismatch of study population and own patients renders the generalizability of study results difficult. Other confounding factors in head-to-head studies are drug comparisons that do not conform to the gold standard, non-equivalent dosages and study duration. To solve these problems clinical research must pick up questions and problems from daily medical care. Studies independent of drug companies should be funded with public money, and health care research needs public support. Access to study protocols and data must be open to the public.
authors.affiliation: Lehrbereich Allgemeinmedizin, Universitätsklinikum Freiburg i. Br. wilhelm.niebling@uniklinik-freiburg.edu
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Niebling
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D000068579:Celecoxib; D057186:Comparative Effectiveness Research; D016265:Conflict of Interest; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use; D017277:Drug Approval / Q000379:methods*; D004345:Drug Industry; D019317:Evidence-Based Medicine / Q000379:methods*; D005858:Germany; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced; D017410:Practice Guidelines as Topic; D017594:Publication Bias; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012109:Research Support as Topic; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D004008:Diclofenac; D000068579:Celecoxib; D007052:Ibuprofen