title: Successful management of rocuronium-induced anaphylactic reactions with sugammadex: a case report.
abstract: Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kochi, 783-8505, Japan. takashika@kochi-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawano
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tamura
authors.forename: Mayuko
authors.initials: M
authors.lastname: Hamaguchi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yatabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Masataka
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D000732:Androstanols / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium