title: Endoscopic mucosal ablation: a new argon plasma coagulation/injection technique to assist complete resection of recurrent, fibrotic colon polyps (with video).
abstract: BACKGROUND
  Incomplete piecemeal EMR of large, sessile/flat colon polyps results in polyp recurrence, with massive submucosal scarring making subsequent attempts at endoscopic resection problematic.
  
  
  OBJECTIVE
  We report our experience with a new endoscopic mucosal ablation (EMA) technique that can be used to complement the eradication of recurrent fibrotic colon polyps.
  
  
  METHODS
  Single-center, retrospective case series.
  
  
  METHODS
  Tertiary-care referral academic endoscopy unit.
  
  
  METHODS
  This study involved consecutive patients referred for endoscopic excision of recurrent benign colon polyps with severe submucosal fibrosis (>30% of the entire lesion).
  
  
  METHODS
  Application of high-power argon plasma coagulation (APC), preceded by injection of a submucosal fluid cushion (normal saline/diluted adrenaline and/or sodium hyaluronate solution) to protect the muscle layer, was performed to augment further piecemeal EMR and polyp eradication.
  
  
  METHODS
  Technical safety and success, complication and recurrence rates.
  
  
  RESULTS
  Fourteen patients (mean age 73 years; 9 men, 5 women) with 15 recurrent colon adenomas (mean polyp size 30 mm, 9 proximal/6 distal) were included. EMA with a mean APC power setting of 55 W was applied. Complete polyp eradication was achieved in 9 of 11 patients (82%) at first or second completed follow-up. One patient needed laparoscopic colectomy because of cancer, and 1 underwent transanal endoscopic microsurgery for benign massive recurrence. The other 3 patients with small, easily treatable recurrence (≤3 mm) were followed by 1-year-surveillance. No perforations and no postpolypectomy syndrome were reported.
  
  
  CONCLUSIONS
  Single-center, nonrandomized case series with short duration follow-up.
  
  
  CONCLUSIONS
  EMA appears to be a safe and easily applicable technique to assist the complete eradication of recurrent fibrotic colon polyps.
authors.affiliation: Wolfson Unit for Endoscopy, St. Mark's Hospital and Academic Institute, Imperial College London, Watford Road, London, HA1 3UJ United Kingdom.
authors.forename: Zacharias P
authors.initials: ZP
authors.lastname: Tsiamoulos
authors.forename: Leonidas A
authors.initials: LA
authors.lastname: Bourikas
authors.forename: Brian P
authors.initials: BP
authors.lastname: Saunders
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D057908:Argon Plasma Coagulation / Q000009:adverse effects; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D003111:Colonic Polyps / Q000473:pathology / Q000601:surgery*; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D005355:Fibrosis; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007413:Intestinal Mucosa / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D012965:Sodium Chloride; D006820:Hyaluronic Acid; D004837:Epinephrine