title: [Contribution of genetic polymorphism to the formation of individual genome sensitivity in workers engaged in heat and power industry].
abstract: The paper presents the results of investigating an association between the frequency of chromosome aberrations and the CYP1A1, CYP1A2*1F GSTM1, and GSTT1 genes involved in xenobiotic biotransformation in workers engaged in heat and power engineering. The group of workers is shown to have a significantly higher rate of metaphases with aberrations (4.03 +/- 0.17%; n = 231) than the control group (2.06 +/- 0.17%; n = 141). Cytogenetic disorders are not found to depend on gender, age, and length of service. The study indicated that the level of chromosome aberrations was significantly higher in carriers of the CTP1A1 C/C, GSTM1 0/0 and GSTT1 0/0 genotypes. In individuals with a combination of the GSTM1 0/0 and GSTT1 0/0 genotypes, the level of chromosome aberrations was ascertained to be significantly higher than that in those with the protective form of these genes.
authors.forename: V I
authors.initials: VI
authors.lastname: Minina
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Savchenko
authors.forename: M L
authors.initials: ML
authors.lastname: Bakanova
authors.forename: A V
authors.initials: AV
authors.lastname: Ostaptseva
authors.forename: O S
authors.initials: OS
authors.lastname: Popova
authors.forename: I V
authors.initials: IV
authors.lastname: Shatalina
authors.forename: L V
authors.initials: LV
authors.lastname: Akin'china
authors.forename: V G
authors.initials: VG
authors.lastname: Druzhinin
mesh_terms: D000328:Adult; D001711:Biotransformation / Q000235:genetics; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000706:statistics & numerical data; D003627:Data Interpretation, Statistical; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity; D016273:Occupational Exposure / Q000009:adverse effects; D011110:Polymorphism, Genetic; D011210:Power Plants; D017132:Workplace / Q000592:standards*; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D009153:Mutagens; D015262:Xenobiotics