title: Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension.
abstract: Ultra-low-dose aspirin has shown a prothrombotic effect in the laser-induced thrombosis model. Several studies of our laboratory have shown a positive effect in rats with two different experimental models of portal hypertension: portal vein ligation, a model with an almost normal liver, and 30 days of bile duct ligation, a model with cirrhosis and presence of ascitis. In both models of portal hypertensive rats, bleeding time was prolonged and thrombi formation, in a laser-induced model of thrombi production, decreased. The hypotheses of the presented studies were that ultra-low-dose aspirin could decrease the bleeding complications in these models and that the mechanism for these effects could act thorough the COX pathway. In different studies, ultra-low dose of aspirin normalized the induced hemorrhage time, thrombi production, and platelet-endothelial cell interaction. The possible beneficial role of these doses of aspirin and mechanism of COX 2 inhibition are discussed.
authors.affiliation: Laboratoire d'Hématologie, UFR des Sciences Pharmaceutiques, Université de Bordeaux 2, Victor Segalen, 33076 Bordeaux Cedex, France.
authors.forename: F X
authors.initials: FX
authors.lastname: Eizayaga
authors.forename: O
authors.initials: O
authors.lastname: Aguejouf
authors.forename: V
authors.initials: V
authors.lastname: Desplat
authors.forename: C
authors.initials: C
authors.lastname: Doutremepuich