title: Endometrioid adenocarcinoma arising from endometriosis: a case report.
abstract: BACKGROUND
  Endometriosis is frequently identified in the ovaries, rectum, pelvic peritoneum, cervix and vagina. However, endometriosis undergoing malignant transformation is a rare event, particularly when the condition manifests itself promptly after initial surgical management.
  
  
  METHODS
  We present a case involving a 52-year-old woman who tested positive for the BRCA1 mutation and was diagnosed with endometriosis in 1999. Two years following treatment, the patient presented with an endometrioid adenocarcinoma; pathologic evaluation indicated that the neoplasm originated from the endometriosis.
  
  
  CONCLUSIONS
  Malignant transformation is a very unusual event and reportedly occurs over several years. Nevertheless, considering the current patient's relatively sudden onset of disease, oncologists should maintain a high index of suspicion in high-risk patients treated surgically for endometriosis who re-present with pelvic symptoms.
authors.affiliation: Gynecologic Oncology Associates, Newport Beach, CA 92663, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Micha
authors.forename: Alberto A
authors.initials: AA
authors.lastname: Mendivil
authors.forename: Howard D
authors.initials: HD
authors.lastname: Epstein
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Laflamme
authors.forename: Bram H
authors.initials: BH
authors.lastname: Goldstein
mesh_terms: D018269:Carcinoma, Endometrioid / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003110:Colonic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004715:Endometriosis / Q000150:complications* / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged