title: Hydrophobically modified biomineralized polysaccharide alginate membrane for sustained smart drug delivery.
abstract: Hydrophobically modified biomineralized polysaccharide alginate membrane with smart drug release property using sodium palmitate as the hydrophobic component was prepared via a one-step method. The formation of CaHPO(4) in the membrane was clearly identified through scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Indomethacin release profiles of the modified alginate membrane were found to be pH- and thermo-responsive. The drug release of modified alginate membrane was around 60% within 12 h, while that of the alginate membrane was higher than 90%. These results indicate that the hydrophobic and biomineralized polysaccharide components can hinder the permeation of the encapsulated drug and reduce the drug release effectively. The resulting membrane can be used as "smart" materials for sustained dual-responsive drug delivery.
authors.affiliation: School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China. shijun@zzu.edu.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wenyan
authors.initials: W
authors.lastname: Qi
authors.forename: Shaokui
authors.initials: S
authors.lastname: Cao
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D011232:Chemical Precipitation; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D008903:Minerals / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D016062:Porosity; D013696:Temperature
chemical_list: D000464:Alginates; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D008903:Minerals; D011134:Polysaccharides; D020723:Glucuronic Acid; C020243:calcium phosphate