title: Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways.
abstract: Transport carriers regulate membrane flow between compartments of the secretory and endocytic pathways in eukaryotic cells. Carrier biogenesis is assisted by microtubules, actin filaments and their associated motors that link to membrane-associated coats, adaptors and accessory proteins. We summarize here how the biochemical properties of membranes inform their interactions with cytoskeletal regulators. We also discuss how the forces generated by the cytoskeleton and motor proteins alter the biophysical properties and the shape of membranes. The interplay between the cytoskeleton and membrane proteins ensures tight spatial and temporal control of carrier biogenesis, which is essential for cellular homeostasis.
authors.affiliation: Biotechnology Centre, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Anitei
authors.forename: Bernard
authors.initials: B
authors.lastname: Hoflack
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D055571:Secretory Pathway / Q000502:physiology*
chemical_list: D008565:Membrane Proteins