title: [Role of (pro)renin receptor in diabetic retinopathy].
abstract: The renin-angiotensin system (RAS), or circulating RAS, is a hormone system that regulates systemic blood pressure. Although several types of organ damage are known to result from the activation of the tissue RAS, the precise mechanism of this activation is not fully understood. The recent discovery of the (pro)renin receptor elucidates the pathogenic mechanism whereby prorenin, by binding to its receptor, dually activates the tissue RAS and RAS-independent intracellular signaling via the receptor. We propose a nomenclature receptor-associated prorenin system (RAPS) for these two major pathways, triggered by the (pro)renin receptor. Recently we showed the association of the RAPS with diabetes-induced retinal inflammation, indicating the possibility of the (pro) renin receptor being a novel molecular target for the treatment of diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan. satofuka@med.teikyo-u.ac.jp
authors.forename: Shingo
authors.initials: S
authors.lastname: Satofuka
mesh_terms: D000818:Animals; D003930:Diabetic Retinopathy / Q000378:metabolism*; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012083:Renin / Q000378:metabolism*; D000093342:Prorenin Receptor
chemical_list: D011956:Receptors, Cell Surface; D012083:Renin; D000093342:Prorenin Receptor