title: Effect of adaptive servo-ventilation on 1-year prognosis in heart failure patients.
abstract: BACKGROUND
  Adaptive servo-ventilation (ASV) has been used as therapy for heart failure (HF). The objective of the present study was to estimate the effect of ASV on 1-year prognosis in HF patients.
  
  
  RESULTS
  After optimizing medical therapy, a 1-year follow-up study was conducted of 85 HF patients (mean age, 72 ± 10 years; 46 men), categorized as New York Heart Association class II-IV. The patients were classified into 2 groups based on adherence to ASV therapy. Use of ASV for ≥ 4h/night was designated as good adherence, and use of ASV for <4h/night was designated as poor adherence. The incidence of fatal cardiovascular events including death from progression of HF, cardioembolic stroke, and fatal cardiac arrhythmias was tracked. Fifty-seven patients were classified into the good adherence group. After 1-year follow-up, the survival rate calculated using Kaplan-Meier analysis was significantly higher in the good adherence group than in the poor adherence group (P=0.0046, log-rank test). In a Cox proportional hazards model, the odds ratio (95% confidence interval) of fatal cardiovascular events was 0.53 (0.27-0.99) for the good ASV adherence group (P=0.046).
  
  
  CONCLUSIONS
  ASV prevents fatal cardiovascular events and improves survival in HF patients.
authors.affiliation: Division of Cardiology, Isesaki Municipal Hospital, Isesaki, Japan. goritakama@db3.so-net.ne.jp
authors.forename: Noriaki
authors.initials: N
authors.lastname: Takama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality / Q000628:therapy*; D006801:Humans; D059725:Interactive Ventilatory Support / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011379:Prognosis; D012121:Respiration, Artificial / Q000379:methods; D015996:Survival Rate; D016896:Treatment Outcome