title: [A case of locally advanced sigmoid colon cancer invading the bladder and seminal vesicle effectively treated with preoperative mFOLFOX6].
abstract: A 77-year-old male was admitted to our hospital complaining of dyschezia. Computed tomography (CT) and colonoscopy (CF) revealed a huge sigmoid colon cancer invading the bladder and seminal vesicle. Chemotherapy with mFOLFOX6 was initiated preoperatively, and the tumor shrunk markedly after seven courses of treatment. Pelvic exenteration with negative margins was carried out. The patient is still alive and disease-free 16 months after surgery. It was suggested that mFOLFOX6 may be useful for advanced colon cancer invading other organs when used as neoadjuvant chemotherapy.
authors.affiliation: Dept. of Surgery, Hamamatsu Medical Center.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Hirayama
authors.forename: Tadataka
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Nishiwaki
authors.forename: Megumu
authors.initials: M
authors.lastname: Kamishima
authors.forename: Satoru
authors.initials: S
authors.lastname: Furuhashi
authors.forename: Hisataka
authors.initials: H
authors.lastname: Fukushima
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Nakata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tamura
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kanai
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ikematsu
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mori
authors.forename: Takachika
authors.initials: T
authors.lastname: Ozawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009361:Neoplasm Invasiveness; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012669:Seminal Vesicles / Q000473:pathology*; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D001743:Urinary Bladder / Q000473:pathology*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil