title: Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease.
abstract: This study assessed the roles of Tau gene short tandem repeats (STRs) nested within intron 1 (rs5820604 and rs10675722) and Apolipoprotein E (ApoE) gene polymorphisms in 70 late-onset Alzheimer's disease (AD) subjects, 70 vascular dementia (VD) subjects, and 70 normal controls (NCs) in Guizhou Han population. Our data suggest that the Tau gene STR loci rs5820604 (CA)(19) allele may increase the risk of AD, whereas the (CA)(16) allele may be protective. The Tau gene STR loci rs10675722 (TA)(17) allele may increase the risk for AD and VD. In addition, a synergistic effect of polymorphisms in ApoE ε4 and Tau gene STR loci rs5820604 (CA)(19) allele was found in the pathogenesis of AD (p = .025, OR [odds ratio] = 3.178, 95% CI [confidence interval] = 1.156-8.741).
authors.affiliation: Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550001, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Dong
authors.forename: Lan
authors.initials: L
authors.lastname: Chu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Zhu
authors.initials: Z
authors.lastname: Xu
authors.forename: Shirong
authors.initials: S
authors.lastname: Li
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Lijun
authors.initials: L
authors.lastname: Cai
authors.forename: Mingming
authors.initials: M
authors.lastname: Dai
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D015140:Dementia, Vascular / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins