title: The curcumin analogue hydrazinocurcumin exhibits potent suppressive             activity on carcinogenicity of breast cancer cells via STAT3 inhibition.
abstract: Curcumin, the active component of turmeric, has been shown to protect against             carcinogenesis and prevent tumor development in cancer. In our study, we tested             the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC),             in breast cancer cells. The results demonstrated that compared to curcumin, HC             was more effective in inhibiting STAT3 phosphorylation and downregulation of an             array of STAT3 downstream targets which contributed to suppression of cell proliferation,             loss of colony formation, depression of cell migration and invasion as well as             induction of cell apoptosis. It was concluded that HC is a potent agent in the             inhibition of STAT3 with more favorable pharmacological activity than curcumin,             and HC may have translational potential as an effective cancer therapeutic or             preventive agent for human breast carcinoma.
authors.affiliation: Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiwen
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenxia
authors.initials: W
authors.lastname: Tian
authors.forename: Wenli
authors.initials: W
authors.lastname: Feng
authors.forename: Tingmei
authors.initials: T
authors.lastname: Chen
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D006834:Hydrazines; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C475807:hydrazinocurcumin; D003474:Curcumin