title: Treatment of primary aspergilloma of the central nervous system in a diabetic immunocompetent patient with surgical resection and voriconazole: a case report and review of the literature.
abstract: Fungal infections of the central nervous system (CNS) are uncommon and occur     mainly in immunocompromised patients. We describe a case of central nervous     system aspergilloma without any evidence of systemic or paranasal foci in a     diabetic but otherwise immunocompetent 71-year-old female treated successfully     with surgical resection and medical therapy with voriconazole. Magnetic     resonance imaging (MRI) after 6 months of voriconazole showed improvement and no     evidence of residual or recurrent disease. Given its good CNS penetration,     voriconazole along with surgical resection appears to be promising in treatment     of these infections. Our case also demonstrates the importance of surgical     intervention in the diagnosis and management of these atypical cases.
authors.affiliation: North Shore University Hospital, Division of Infectious Diseases, Manhasset, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Koshy
authors.forename: Prashant
authors.initials: P
authors.lastname: Malhotra
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D048909:Diabetes Complications / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D007121:Immunocompetence / Q000502:physiology; D020953:Neuroaspergillosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods; D011743:Pyrimidines / Q000008:administration & dosage*; D013702:Temporal Lobe / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole