title: Influence of gender donor-recipient combinations on survival after human lung transplantation.
abstract: BACKGROUND
  In the current practice of lung transplantation, donor and recipient genders are neither directly considered nor matched. However, some data have suggested a possible effect of gender combinations on survival following lung transplantation.
  
  
  METHODS
  A total of 249 adult lung transplant recipients at a single center between February 1988 and December 2008, were analyzed retrospectively for donor-recipient gender matching. We compared the mortality by calculating one-term survival rates after transplantation using the Kaplan-Meier method with comparisons using the log-rank (Mantel-Cox) test. Statistical significance of the mean effects of size matching was assessed by paired Student t tests and Wilcoxon signed rank tests.
  
  
  RESULTS
  Kaplan-Meier survival analysis shown that male compared to female recipients did not have an effect on outcomes after lung transplantation at 5 years (P=.5379), 10 years (P=.107), 15 years (P=.0841), 20 years (P=.0711). No effect of gender on lung transplantation outcomes was observed with donor-recipient gender mismatches at 5 years (P=.1804), 10 years (P=.1457), 15 years (P=.0731), or 20 years (P=.0629). Similarly, no differences were observed for each gender combination. The degree of size matching was defined as the ratio of donor-to-recipient predicted total lung capacity. The ratios were similar for the donor-recipient gender match and significantly different for the donor-recipient gender mismatch.
  
  
  CONCLUSIONS
  These analyses suggested that gender was not a significant independent risk factor affecting survival after lung transplantation. Size mismatch caused by gender mismatch did not increase mortality.
authors.affiliation: Bordeaux University, Bordeaux Cardiothoracic Research Center, Inserm U1045, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Fessart
authors.forename: C
authors.initials: C
authors.lastname: Dromer
authors.forename: M
authors.initials: M
authors.lastname: Thumerel
authors.forename: J
authors.initials: J
authors.lastname: Jougon
authors.forename: F
authors.initials: F
authors.lastname: Delom
mesh_terms: D000328:Adult; D005260:Female; D005602:France; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D055815:Young Adult