title: A predictive model of suitability for minimally invasive parathyroid surgery in the treatment of primary hyperparathyroidism [corrected].
abstract: BACKGROUND
  Improved preoperative localizing studies have facilitated minimally invasive approaches in the treatment of primary hyperparathyroidism (PHPT). Success depends on the ability to reliably select patients who have PHPT due to single-gland disease. We propose a model encompassing preoperative clinical, biochemical, and imaging studies to predict a patient's suitability for minimally invasive surgery.
  
  
  METHODS
  For the purposes of the present study, 180 consecutive patients were included for analysis. A 5-variable model based on preoperative ionized serum calcium (>1.4 mmol/l), intact parathyroid hormone level (≥ 2 times the upper limit of normal), positive sestamibi scan for a single affected gland, positive ultrasound scan for a single gland, and concordance between the two imaging modalities for single-gland disease at a similar location was employed, where a score of 1 was allocated for each variable present.
  
  
  RESULTS
  Of the 180 patients, 62 (34%) underwent bilateral exploration, 63 (36%) underwent unilateral exploration, and 55 (30%) underwent minimally invasive parathyroidectomy. The results showed that 92% had single-gland disease, 3% had double adenomas, and 5% had hyperplasia. Biochemical cure was achieved in 98.9%. Mean follow-up was 153 days (range: 80-342 days). With the predictive scoring model, a score of ≥ 3 had a positive predictive value of 100% for single-gland disease.
  
  
  CONCLUSIONS
  A scoring model encompassing preoperative biochemical and imaging data can be successfully employed to predict suitability for minimally invasive surgery in the majority of patients with single-gland disease.
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland. dara_kav@hotmail.com.
authors.forename: Dara O
authors.initials: DO
authors.lastname: Kavanagh
authors.affiliation: Department of Medicine, Physiotherapy & Population Science, School of Public Health Medicine, University College Dublin, Belfield, Dublin 4, Ireland.|School of Medicine & Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Fitzpatrick
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Eddie
authors.initials: E
authors.lastname: Myers
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Rory
authors.initials: R
authors.lastname: Kennelly
authors.affiliation: Department of Radiology, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Skehan
authors.affiliation: Department of Radiology, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Gibney
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Arnold D K
authors.initials: ADK
authors.lastname: Hill
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Denis
authors.initials: D
authors.lastname: Evoy
authors.affiliation: Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Enda W
authors.initials: EW
authors.lastname: McDermott
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D003661:Decision Support Techniques; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D008962:Models, Theoretical; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000379:methods*; D011300:Preoperative Care / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D002118:Calcium