title: Association between peroxisome proliferator-activated  receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians  in Inner Mongolia.
abstract: We investigated a possible association of peroxisome  proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension  in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled  randomly, including 390 hypertension patients and 397 healthy controls.  Triglycerides, cholesterol, and fasting plasma glucose were measured, and body  mass index was calculated. PCR-RFLP was used to analyze Gly482Ser  polymorphisms. There were significant differences in triglycerides, fasting  plasma glucose, and body mass index between hypertension patients and healthy  controls. Cholesterol levels did not differ significantly. The PGC-1α gene GG, GA and AA genotype distributions  were 37.2, 48.5 and 14.4%, respectively, in patients and 48.6, 37.3 and 14.1%  in healthy controls. The frequencies of PGC-1α genotype GA and allele A were  significantly different between hypertension patients and healthy Mongolians.  We concluded that PGC-1α Gly482Ser polymorphism is associated with  hypertension in Mongolians in Inner Mongolia.
authors.affiliation: Clinical Research Center of Affiliated Hospital, Inner Mongolian Medical College, Hohhot, Inner Mongolia, China. xlsu@hotmail.com
authors.forename: X L
authors.initials: XL
authors.lastname: Su
authors.forename: H R
authors.initials: HR
authors.lastname: Dong
authors.forename: M R
authors.initials: MR
authors.lastname: Yan
authors.forename: H W
authors.initials: HW
authors.lastname: Cui
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: F Q
authors.initials: FQ
authors.lastname: Han
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors