title: [Hepatoprotectors in therapy of the alcoholic liver disease (clinical and experimental research)].
abstract: The aim of this study was a comparative evaluation of the effectiveness of hepatoprotectors (Metadoksin and Silybin) in the complex treatment of patients with alcoholic liver disease. The article presents data on the use of Metadoksin and Silybin in the treatment of alcohol steatohepatitis and liver cirrhosis alcoholic etiology of the total number of comparison groups 66 patients formed on the basis of 642 patients treated with alcoholic liver disease. Was studied dynamics of blood biochemical parameters during therapy, as well as the severity of clinical syndrome (pain, dyspeptic, asthenic) before and after treatment. Higher Metadoksin efficacy in comparison with Silybin explained by antidepressiv effect of the drug. The effect of restoration of damaged toxic effect of alcohol liver tissue as a result of Metadoksin impact was proved in the experimental part of the study, an experiment on rats.
authors.forename: T F
authors.initials: TF
authors.lastname: Fedotova
authors.forename: I E
authors.initials: IE
authors.lastname: Trubitsina
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000009:adverse effects; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D051381:Rats; D000077385:Silybin; D012838:Silymarin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000975:Antioxidants; D012838:Silymarin; D000077385:Silybin