title: Vertical modelling: Analysis of competing risks data with missing causes of failure.
abstract: We propose vertical modelling as a natural approach to the problem of analysis of competing risks data when failure types are missing for some individuals. Under a natural missing-at-random assumption for these missing failure types, we use the observed data likelihood to estimate its parameters and show that the all-cause hazard and the relative hazards appearing in vertical modelling are indeed key quantities of this likelihood. This fact has practical implications in that it suggests vertical modelling as a simple and attractive method of analysis in competing risks with missing causes of failure; all individuals are used in estimating the all-cause hazard and only those with non-missing cause of failure for relative hazards. The relative hazards also appear in a multiple imputation approach to the same problem proposed by Lu and Tsiatis and in the EM algorithm. We compare the vertical modelling approach with the method of Goetghebeur and Ryan for a breast cancer data set, highlighting the different aspects they contribute to the data analysis.
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. M.A.Nicolaie@lumc.nl.
authors.forename: M A
authors.initials: MA
authors.lastname: Nicolaie
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: van Houwelingen
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Putter
mesh_terms: D000465:Algorithms; D006801:Humans; D053208:Kaplan-Meier Estimate; D016013:Likelihood Functions; D015233:Models, Statistical; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods*; D016019:Survival Analysis; D017211:Treatment Failure