title: Absolute eosinophils count as a marker of mortality in patients with severe sepsis and septic shock in an intensive care unit.
abstract: BACKGROUND
  Eosinophils in the circulating blood undergo apoptosis during sepsis syndromes induced by the action of certain cytokines.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the absolute eosinophils count (EC) as a marker of mortality in severe sepsis and septic shock.
  
  
  METHODS
  A prospective cohort study of patients with a diagnosis of sepsis or septic shock admitted to the intensive care unit (ICU) of the Dr Gustavo Fricke Hospital between January 2008 and December 2009 was conducted. Daily EC in all patients was analyzed. Receiver operating characteristic curve analysis was used to assess the performance of the diagnostic test.
  
  
  RESULTS
  We studied a total of 240 patients. The median age was 62 years (interquartile range [IQR], 48-72 years), and 67 (27.9%) died. The median EC in patients who died was 43 (IQR, 14-121), whereas in surviving patients, it was 168 (IQR, 98-292) (P < .001). When the EC on the fifth day of hospital stay was assessed, an area under the curve (AUC) of 0.64 (95% confidence interval, 0.55-0.73) was observed. Eosinophils count at intensive care unit discharge showed an area under the curve of 0.81 (95% confidence interval, 0.76-0.87).
  
  
  CONCLUSIONS
  Eosinophils counts were lower in patients who died of sepsis than in those who survived, but its clinical usefulness seems limited. Their role as an indicator of clinical stability seems to be important.
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Gustavo Fricke. Valparaíso, Chile. carlosmerinom@vtr.net
authors.forename: Carlos Adolfo
authors.initials: CA
authors.lastname: Merino
authors.forename: Felipe Tomás
authors.initials: FT
authors.lastname: Martínez
authors.forename: Felipe
authors.initials: F
authors.lastname: Cardemil
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Rodríguez
mesh_terms: D000368:Aged; D015415:Biomarkers; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000378:metabolism
chemical_list: D015415:Biomarkers