title: Amelioration of age associated neuroinflammation on long term bacosides treatment.
abstract: Bacopa monnieri (L.) is a revered medicinal plant of traditional Indian system of medicine effective against cognitive impairment in ageing and SDAT. In our previous study, long term administration of bacosides was found to exhibit remarkable anti ageing effect, ameliorate age associated neurochemical and neurobehavioral deficits and prevent hippocampal neuronal degeneration in middle aged and aged rat brain cortex. In continuation to the previous study, the present study aims to investigate the neuroprotective effect of bacosides against age related chronic neuroinflammation in Wistar rat brain on 3 months treatment. Recently, neuroinflammation has gained considerable interest in age associated neurodegeneration and pathologies like SDAT due to its slow onset and chronic nature. The results of the present study demonstrated the significant attenuation of age dependant elevation of pro inflammatory cytokines, iNOS protein expression, total nitrite and lipofuscin content in middle aged and aged rat brain cortex on long term oral administration of bacosides. Thus, the present results suggest that bacosides possess immense potential to act as a neuroprotective agent due to its pleiotropic action for the prevention of ageing complications and SDAT progression.
authors.affiliation: Centre for Advanced Research in Indian System of Medicine-CARISM, SASTRA University, Thanjavur, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Rastogi
authors.forename: Rudra P
authors.initials: RP
authors.lastname: Ojha
authors.forename: B Parimala
authors.initials: BP
authors.lastname: Devi
authors.forename: Aabha
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Aruna
authors.initials: A
authors.lastname: Agrawal
authors.forename: G P
authors.initials: GP
authors.lastname: Dubey
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D034681:Bacopa; D005260:Female; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018836:Inflammation Mediators; D018696:Neuroprotective Agents; D010936:Plant Extracts; D012503:Saponins