title: Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair.
abstract: OBJECTIVE
  The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR).
  
  
  METHODS
  Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak.
  
  
  CONCLUSIONS
  Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.
authors.affiliation: Department of Surgery, Maastricht University Medical Center, The Netherlands. f.hellenthal@mumc.nl
authors.forename: F A M V I
authors.initials: FA
authors.lastname: Hellenthal
authors.forename: J A
authors.initials: JA
authors.lastname: Ten Bosch
authors.forename: B
authors.initials: B
authors.lastname: Pulinx
authors.forename: W K W H
authors.initials: WK
authors.lastname: Wodzig
authors.forename: M W
authors.initials: MW
authors.lastname: de Haan
authors.forename: M H
authors.initials: MH
authors.lastname: Prins
authors.forename: R J T J
authors.initials: RJ
authors.lastname: Welten
authors.forename: J A W
authors.initials: JA
authors.lastname: Teijink
authors.forename: G W H
authors.initials: GW
authors.lastname: Schurink
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery; D015415:Biomarkers / Q000097:blood*; D019917:Blood Vessel Prosthesis Implantation; D016022:Case-Control Studies; D057867:Endoleak / Q000097:blood / Q000000981:diagnostic imaging; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D011480:Protease Inhibitors / Q000097:blood; D012372:ROC Curve; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D011480:Protease Inhibitors; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9