title: Current trends in miRNAs and their relationship with oral squamous cell carcinoma.
abstract: A micro RNA (miRNA) is a single-stranded endogenous, non-coding RNA, with length ranging between 18 and 24 nucleotides and the ability of regulating the expression of other genes on a post-transcriptional level by means of various processes, degradation or repression of target mRNA. miRNAs play a crucial role in regulating fundamental processes such as cell cycle, differentiation and apoptosis; thus, their deregulation can affect normal cell growth and development, and even participate in carcinogenesis. The goals of this paper are: to outline the formation and functions of miRNAs; to determine their role in oral squamous cell carcinoma; to analyze the different miRNAs described and their roles as oncogenes or tumor suppressor genes, depending on their overexpression or subexpression; to describe the different polymorphisms and epigenetic alterations identified; and to determine their role in multidrug resistance.
authors.affiliation: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain. perezsayans@gmail.com
authors.forename: Mario
authors.initials: M
authors.lastname: Pérez-Sayáns
authors.forename: Gayoso-Diz
authors.initials: GD
authors.lastname: Pilar
authors.forename: Francisco
authors.initials: F
authors.lastname: Barros-Angueira
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Suárez-Peñaranda
authors.forename: Alexia Conde
authors.initials: AC
authors.lastname: Fernández
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Gándara-Rey
authors.forename: Abel
authors.initials: A
authors.lastname: García-García
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D035683:MicroRNAs