title: De novo CNVs in bipolar disorder: recurrent themes or new directions?
abstract: In this issue of Neuron, Malhotra and colleagues report an enrichment of de novo copy number variants in bipolar disorder and schizophrenia when compared with those of controls. The study highlights the importance of a genetic model involving rare and disruptive variants to further our understanding of complex neuropsychiatric traits.
authors.affiliation: Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
authors.forename: Santhosh
authors.initials: S
authors.lastname: Girirajan
authors.forename: Evan E
authors.initials: EE
authors.lastname: Eichler
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000235:genetics*