title: Correlation between corneal biomechanical properties, applanation tonometry and direct intracameral tonometry.
abstract: OBJECTIVE
  To investigate the correlation between corneal biomechanical properties, applanation tonometry and direct intracameral tonometry.
  
  
  METHODS
  Patients scheduled for phacoemulsification were enrolled in this prospective observer-masked study. Central corneal thickness (CCT) was obtained with ultrasound pachymetry. Corneal biomechanical properties including corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with the ocular response analyser. Applanation intraocular pressure (IOP) (IOPappla) was measured in the supine position. Intracameral IOP (IOPintra) was measured with a pressure transducer connected to a cannula inserted into the anterior chamber.
  
  
  RESULTS
  Fifty-eight eyes of 58 patients were included. There was a significant difference between IOPappla and IOPintra (17.3±4.1 vs 13.8±4.7 mm Hg, p<0.001). CCT was significantly correlated with CH and CRF (p<0.01). Univariate regression analysis revealed IOPappla was significantly correlated with CCT and CRF (p<0.05). IOPintra had no significant association with the corneal properties (p>0.05). Multivariate regression analysis revealed IOPappla=10.43+2.69CRF-1.99CH (p<0.001) and the difference between IOPappla and IOPintra (ΔIOP)=-1.57+0.55CRF (p=0.032).
  
  
  CONCLUSIONS
  The mean difference between IOPappla and IOPintra was 3.5 mm Hg. While IOPappla was correlated with the corneal biomechanical properties of CH and CRF, IOPintra was not. IOPappla was correlated more with the corneal biomechanical properties assessed by the ocular response analyser than with CCT alone.
authors.affiliation: School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China.
authors.forename: A-Yong
authors.initials: AY
authors.lastname: Yu
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Duan
authors.forename: Yun-E
authors.initials: YE
authors.lastname: Zhao
authors.forename: Xing-Yu
authors.initials: XY
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Lu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
authors.forename: Qin-Mei
authors.initials: QM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena / Q000502:physiology; D003315:Cornea / Q000502:physiology* / Q000601:surgery; D004547:Elastic Tissue; D004548:Elasticity / Q000502:physiology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D016683:Supine Position; D014065:Tonometry, Ocular