title: From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
abstract: Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors.
authors.affiliation: Department of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
authors.forename: Oana
authors.initials: O
authors.lastname: Draghiciu
authors.forename: Hans W
authors.initials: HW
authors.lastname: Nijman
authors.forename: Toos
authors.initials: T
authors.lastname: Daemen
mesh_terms: D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007157:Immunologic Surveillance; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*