title: Inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism.
abstract: OBJECTIVE
  To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT).
  
  
  METHODS
  A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects.
  
  
  RESULTS
  Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 ± 0.54 vs. 2.24 ± 0.11 mg/l; IL-6: 4.50 ± 0.80 vs. 2.56± 0.29 pg/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively).
  
  
  CONCLUSIONS
  Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients.
authors.affiliation: Department of Internal Medicine, National Research Center, Cairo, Egypt. ahmedemam6@hotmail.com
authors.forename: Ahmed Alsayed
authors.initials: AA
authors.lastname: Emam
authors.forename: Sabela Gomaa
authors.initials: SG
authors.lastname: Mousa
authors.forename: Karema Yousif
authors.initials: KY
authors.lastname: Ahmed
authors.forename: Adel A
authors.initials: AA
authors.lastname: Al-Azab
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein; D016022:Case-Control Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis / Q000473:pathology*; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein