title: The differential effect of risperidone and olanzapine on insulin sensitivity after 3 weeks of treatment: a HOMA pilot study.
abstract: METHODS
  Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n = 7) or risperidone (n = 7).
  
  
  CONCLUSIONS
  The HOMA-IS index was reduced in the olanzapine group, but significantly increased in patients treated with risperidone. There was a significant "time × medication" interaction (p = 0.03). The BMI significantly increased as a result of both treatments. IS can be acutely ameliorated by antipsychotic treatment with risperidone despite weight increase.
  
  
  CONCLUSIONS
  Compared to risperidone, the IS is impaired after a 3-week treatment with olanzapine. Already short-term antipsychotic treatment may have eff ects on insulin sensitivity.
authors.affiliation: Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany. Georgios.Paslakis@zi-mannheim.de
authors.forename: G
authors.initials: G
authors.lastname: Paslakis
authors.forename: M
authors.initials: M
authors.lastname: Deuschle
authors.forename: J
authors.initials: J
authors.lastname: Thome
authors.forename: S
authors.initials: S
authors.lastname: Rüsse
authors.forename: D
authors.initials: D
authors.lastname: Kopf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D015992:Body Mass Index; D005260:Female; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged; D000077152:Olanzapine; D010865:Pilot Projects; D011446:Prospective Studies; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine