title: Exercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female rats.
abstract: OBJECTIVE
  We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats.
  
  
  METHODS
  Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemic sedentary (HS)], normoglycemic trained rats (NT) and normoglycemic sedentary rats (NS). Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). One day after the last exercise protocol (60 min/day, five days/week for eight weeks) in the trained groups or after water stress exposure (ten min/twice a week) in the sedentary groups, the rats were subjected to a hot plate test.
  
  
  RESULTS
  After eight weeks of swimming training, streptozotocin-induced diabetic rats presented a significantly lower body mass (trained: 219.5 ± 29 g, sedentary: 217.8 ± 23 g) compared with the normoglycemic groups (trained: 271 ± 24 g, sedentary: 275.7 ± 32 g). Interestingly, we did not find differences in blood glucose levels (mg/dl) between the trained and sedentary groups of the hyperglycemic or normoglycemic rats (HT: 360.2 ± 66.6, HS: 391.7 ± 66.7, NT: 83.8 ± 14.0, NS: 77.5 ± 10.1). In the hot plate test, the rats from the HT group presented a significantly lower latency than the other rats (HT: 11.7 ± 7.38 s, HS: 7.02 ± 7.38 s, NT: 21.21 ± 7.64 s, NS: 22.82 ± 7.82 s).
  
  
  CONCLUSIONS
  Low-to-moderate swimming training for a long duration reduces thermal hyperalgesia during a hot plate test in streptozotocin-induced diabetic female rats.
authors.affiliation: Departamento de Educação Especial, Faculdade de Filosofia e Ciência, UNESP, Marília, SP, Brasil. denisemartineli@hotmail.com
authors.forename: Denise M
authors.initials: DM
authors.lastname: Rossi
authors.forename: Vitor E
authors.initials: VE
authors.lastname: Valenti
authors.forename: Marcelo T
authors.initials: MT
authors.lastname: Navega
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006358:Hot Temperature; D006930:Hyperalgesia / Q000503:physiopathology* / Q000628:therapy; D010147:Pain Measurement / Q000379:methods*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology*; D013550:Swimming / Q000502:physiology*
chemical_list: D001786:Blood Glucose