title: Successful double bypass in a patient with severe hemophilia A: a case report.
abstract: Life expectancy in the hemophilia people is similar to the non-haemophilics and age-related cardiovascular disorders to become more prevalent, but cardiac surgery is considered a very high risk for these patients. In this article we report the successful cardiac double bypass internal mammary artery--coronary artery in a patient with severe hemophilia A. (FVIII<1%; missense mutation: exon 16, c.5508 G>A (domain A3), p.Trp1817Stop). Continuous infusion of rFVIII B-domain deleted was used to control haemostasis during surgery and in post-operative period. There was no bleeding complications and the patient did not need to receive transfusion of red blood cells or platelets.
authors.affiliation: Center for Hemorrhagic and Thrombotic Diseases, University Hospital of Udine, P.le S. Maria della Misericordia, 15, 33100, Udine, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barillari
authors.forename: Samantha
authors.initials: S
authors.lastname: Pasca
authors.forename: Filippo
authors.initials: F
authors.lastname: Erice
authors.forename: Ugolino
authors.initials: U
authors.lastname: Livi
mesh_terms: D001026:Coronary Artery Bypass / Q000379:methods; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index