title: HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypes.
abstract: The hepatitis A virus cellular receptor 1 (HAVCR1) gene is highly polymorphic, and several variants have been associated with susceptibility to allergic and autoimmune diseases. The HAVCR1 gene region was identified as a candidate for hepatitis C virus (HCV) natural clearance in a genotyping study of selected immune response genes in both European-American and African-American populations. The aim of the present study was to explore the influence of HAVCR1 in the outcome of HCV infection in the Spanish population. Three cohorts, consisting of 354 subjects with persistent HCV infection (285 with persistent HCV monoinfection and 69 with natural clearance), 182 coinfected HIV/HCV patients, and 320 controls, were included. Samples were genotyped in several polymorphic positions, insertion/deletion variants in exon 4 and tag single nucleotide polymorphisms (SNPs), in order to define previously described HAVCR1 haplotypes (haplotypes A to D). No statistically significant differences were observed with spontaneous resolution of infection or with viral clearance after treatment. Nevertheless, different rates of infection by viral genotypes (G's) were observed among the HAVCR1 haplotypes. Individuals bearing haplotype C had the highest viral G1 infection rate when compared to individuals bearing other haplotypes (75.82% versus 57.72%, respectively; corrected P value [P(c)], 3.2 × 10(-4); odds ratio [OR], 2.30; 95% confidence interval [CI], 1.51 to 3.47). Thus, HAVCR1 could be involved in susceptibility or resistance to infection by a particular HCV genotype.
authors.affiliation: Servicio de Inmunología, Hospital Universitario Virgen del Rocío/Instituto de Biomedicina, Sevilla, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Abad-Molina
authors.forename: José-Raúl
authors.initials: JR
authors.lastname: Garcia-Lozano
authors.forename: Marco-Antonio
authors.initials: MA
authors.lastname: Montes-Cano
authors.forename: Almudena
authors.initials: A
authors.lastname: Torres-Cornejo
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Torrecillas
authors.forename: José
authors.initials: J
authors.lastname: Aguilar-Reina
authors.forename: Manuel
authors.initials: M
authors.lastname: Romero-Gómez
authors.forename: Luis-Fernando
authors.initials: LF
authors.lastname: López-Cortés
authors.forename: Antonio
authors.initials: A
authors.lastname: Núñez-Roldan
authors.forename: María-Francisca
authors.initials: MF
authors.lastname: González-Escribano
mesh_terms: D005260:Female; D005838:Genotype; D006239:Haplotypes; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D000072596:Hepatitis A Virus Cellular Receptor 1; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011991:Receptors, Virus / Q000235:genetics*; D013030:Spain
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus