title: Maternal antibody persistence: a neglected life-history trait with implications from albatross conservation to comparative immunology.
abstract: The evolution of different life-history strategies has been suggested as a major force constraining physiological mechanisms such as immunity. In some long-lived oviparous species, a prolonged persistence of maternal antibodies in offspring could thus be expected in order to protect them over their long growth period. Here, using an intergenerational vaccination design, we show that specific maternal antibodies can display an estimated half-life of 25 days post-hatching in the nestlings of a long-lived bird. This temporal persistence is much longer than previously known for birds and it suggests specific properties in the regulation of IgY immunoglobulin catabolism in such a species. We also show that maternal antibodies in the considered procellariiform species are functional as late as 20 days of age. Using a modelling approach, we highlight that the potential impact of such effects on population viability could be important, notably when using vaccination for conservation. These results have broad implications, from comparative immunology to evolutionary eco-epidemiology and conservation biology.
authors.affiliation: Centre d'Ecologie Fonctionnelle et Evolutive, CNRS-UMR 5175, Montpellier, France.
authors.forename: R
authors.initials: R
authors.lastname: Garnier
authors.forename: R
authors.initials: R
authors.lastname: Ramos
authors.forename: V
authors.initials: V
authors.lastname: Staszewski
authors.forename: T
authors.initials: T
authors.lastname: Militão
authors.forename: E
authors.initials: E
authors.lastname: Lobato
authors.forename: J
authors.initials: J
authors.lastname: González-Solís
authors.forename: T
authors.initials: T
authors.lastname: Boulinier
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000906:Antibodies / Q000276:immunology*; D001717:Birds / Q000276:immunology*; D003247:Conservation of Natural Resources; D005260:Female; D007109:Immunity; D014611:Vaccination / Q000662:veterinary
chemical_list: D000906:Antibodies