title: R we there yet? R-loop hazards to finishing the journey.
abstract: RNA:DNA hybrids in the genome are constantly being generated as a by-product of transcription; in this issue, two papers, from Helmrich et al. (2011) and Wahba et al. (2011), provide insight into how RNA:DNA hybrids lead to genetic instability.
authors.affiliation: Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Potenski
authors.forename: Hannah L
authors.initials: HL
authors.lastname: Klein