title: Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of    tumour growth.
abstract: Loss of function of pins (partner of inscuteable) partially disrupts neuroblast (NB)     polarity and asymmetric division, results in fewer and smaller NBs and inhibits      Drosophila larval brain growth. Food deprivation also inhibits growth. However, we find     that the combination of loss of function of pins and dietary restriction results in loss of NB     asymmetry, overproliferation of Miranda-expressing cells, brain overgrowth and increased     frequency of tumour growth on allograft transplantation. The same effects are observed in     well-fed pins larvae that are mutant for pi3k (phosphatidylinositol 3-kinase) or     exposed to the TOR inhibitor rapamycin. Thus, pathways that are sensitive to food deprivation     and dependent on PI3K and TOR are essential to suppress tumour growth in Drosophila     larval brains with compromised pins function. These results highlight an unexpected crosstalk     whereby the normally growth-promoting, nutrient-sensing PI3K/TOR pathway suppresses tumour     formation in neural stem cells with compromised cell polarity.
authors.affiliation: Cell Division Group, Institute for Research in Biomedicine,      Baldiri Reixac 10, 08028     Barcelona, Spain.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Rossi
authors.forename: Cayetano
authors.initials: C
authors.lastname: Gonzalez
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000201:enzymology / Q000473:pathology*; D031204:Caloric Restriction; D018797:Cell Cycle Proteins / Q000378:metabolism; D016764:Cell Polarity; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000201:enzymology* / Q000473:pathology*; D029721:Drosophila Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology*; D004734:Energy Metabolism; D020730:Guanine Nucleotide Dissociation Inhibitors; D007814:Larva / Q000254:growth & development / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D013217:Starvation; D013312:Stress, Physiological; D058570:TOR Serine-Threonine Kinases
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D020730:Guanine Nucleotide Dissociation Inhibitors; C107613:Mira protein, Drosophila; C405164:Pins protein, Drosophila; D011494:Protein Kinases; C416303:target of rapamycin protein, Drosophila; D058539:Phosphatidylinositol 3-Kinase; D058570:TOR Serine-Threonine Kinases