title: Evaluation of coronary blood flow velocity during cardiac arrest with circulation maintained through mechanical chest compressions in a porcine model.
abstract: BACKGROUND
  Mechanical chest compressions (CCs) have been shown capable of maintaining circulation in humans suffering cardiac arrest for extensive periods of time. Reports have documented a visually normalized coronary blood flow during angiography in such cases (TIMI III flow), but it has never been actually measured. Only indirect measurements of the coronary circulation during cardiac arrest with on-going mechanical CCs have been performed previously through measurement of the coronary perfusion pressure (CPP). In this study our aim was to correlate average peak coronary flow velocity (APV) to CPP during mechanical CCs.
  
  
  METHODS
  In a closed chest porcine model, cardiac arrest was established through electrically induced ventricular fibrillation (VF) in eleven pigs. After one minute, mechanical chest compressions were initiated and then maintained for 10 minutes upon which the pigs were defibrillated. Measurements of coronary blood flow in the left anterior descending artery were made at baseline and during VF with a catheter based Doppler flow fire measuring APV. Furthermore measurements of central (thoracic) venous and arterial pressures were also made in order to calculate the theoretical CPP.
  
  
  RESULTS
  Average peak coronary flow velocity was significantly higher compared to baseline during mechanical chests compressions and this was observed during the entire period of mechanical chest compressions (12 - 39% above baseline). The APV slowly declined during the 10 min period of mechanical chest compressions, but was still higher than baseline at the end of mechanical chest compressions. CPP was simultaneously maintained at > 20 mmHg during the 10 minute episode of cardiac arrest.
  
  
  CONCLUSIONS
  Our study showed good correlation between CPP and APV which was highly significant, during cardiac arrest with on-going mechanical CCs in a closed chest porcine model. In addition APV was even higher during mechanical CCs compared to baseline. Mechanical CCs can, at minimum, re-establish coronary blood flow in non-diseased coronary arteries during cardiac arrest.
authors.affiliation: Department of Cardiology, Skane University Hospital, Lund, Lund University, SE-221 85 Lund, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Wagner
authors.forename: Bjarne
authors.initials: B
authors.lastname: Madsen Hardig
authors.forename: Stig
authors.initials: S
authors.lastname: Steen
authors.forename: Trygve
authors.initials: T
authors.lastname: Sjoberg
authors.forename: Jan
authors.initials: J
authors.lastname: Harnek
authors.forename: Goran K
authors.initials: GK
authors.lastname: Olivecrona
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D015150:Echocardiography, Doppler; D006323:Heart Arrest / Q000503:physiopathology*; D006336:Heart Massage; D023421:Models, Animal; D013552:Swine