title: NMR insights into protein allostery.
abstract: Allosterism is one of nature's principal methods for regulating protein function. Allosterism utilizes ligand binding at one site to regulate the function of the protein by modulating the structure and dynamics of a distant binding site. In this review, we first survey solution NMR techniques and how they may be applied to the study of allostery. Subsequently, we describe several examples of application of NMR to protein allostery and highlight the unique insight provided by this experimental technique.
authors.affiliation: Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven, CT 06520-8107, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Manley
authors.forename: J Patrick
authors.initials: JP
authors.lastname: Loria
mesh_terms: D000494:Allosteric Regulation; D007700:Kinetics; D009068:Movement; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011506:Proteins