title: Increased Helicobacter felis colonization in male 129/Sv mice fails to suppress gastritis.
abstract: Development of the pathologies associated with Helicobacter pylori infection, most seriously gastric adenocarcinoma, are a consequence of chronic inflammation, which both host and pathogen go to some lengths to minimize. Recently, we presented evidence that H. pylori can suppress the development of inflammation in its immediate microenvironment in the gastric mucosa of 129/Sv mice. We have now extended this study by showing that H. felis, a gastric colonizing Helicobacter closely related to H. pylori, does not possess the same ability to suppress Helicobacter-induced gastritis in mice. Differences between these bacterial species may provide clues as to the mechanism behind the inflammation-regulating ability of H. pylori. Moreover, our demonstration that H. pylori but not H. felis can locally suppress inflammation in vivo may explain why H. felis infection induces superior levels of gastritis as compared with H. pylori infection of mice.
authors.affiliation: Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, VIC Australia.
authors.forename: Garrett
authors.initials: G
authors.lastname: Ng
authors.forename: Alison
authors.initials: A
authors.lastname: Every
authors.forename: Michael
authors.initials: M
authors.lastname: McGuckin
authors.forename: Philip
authors.initials: P
authors.lastname: Sutton
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D044922:Helicobacter felis / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity; D016480:Helicobacter pylori / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D007249:Inflammation / Q000382:microbiology; D008297:Male; D051379:Mice; D057507:Mice, 129 Strain; D012737:Sex Factors; D013045:Species Specificity; D018709:Statistics, Nonparametric
chemical_list: D004269:DNA, Bacterial