title: Development of transmucosal patch using nanofibers.
abstract: In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy.
authors.affiliation: Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship, College of Pharmacy, Moga, Punjab, India.
authors.forename: Harleen
authors.initials: H
authors.lastname: Grewal
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Dhakate
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
authors.forename: Tanmay S
authors.initials: TS
authors.lastname: Markandeywar
authors.forename: Basant
authors.initials: B
authors.lastname: Malik
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
mesh_terms: D058956:Administration, Mucosal; D004008:Diclofenac / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D057139:Nanofibers; D011091:Polyesters / Q000737:chemistry; D013997:Time Factors
chemical_list: D011091:Polyesters; D004008:Diclofenac; C016240:polycaprolactone