title: Goldberger's electrocardiographic triad in patients with echocardiographic severe left ventricular dysfunction.
abstract: In 1982, Goldberger described an electrocardiographic triad (SV1 or SV2 + RV5 or RV6 ≥ 3.5 mV, total QRS amplitude in each of the limb leads ≤ 0.8 mV, and R/S ratio < 1 in lead V4) that was 70% sensitive and > 90% specific for detecting severe left ventricular (LV) dysfunction. To confirm his sensitivity results, in 51 consecutive patients (36 men) aged 28 to 84 years (mean 56) with LV ejection fractions ≤ 20%, the electrocardiographic triad was sought in the electrocardiogram (ECG) recorded closest in time to the echocardiographic study. All 51 patients had systemic arterial hypertension. Evidence of ischemia was present in 7 and absent in 38, and in 6 patients, ischemic status was unknown. In 49 patients, New York Heart Association functional class was available: class II in 8, class III in 32, and class IV in 9. LV ejection fractions ranged from 4% to 20% (mean 14%), and LV internal end-diastolic diameters ranged from 5.7 to 8.6 cm (mean 6.6). Left atrial anteroposterior diameters ranged from 2.9 to 6.1 cm (mean 4.7) and were ≥ 4.0 cm in 47 of the 51 patients. The right ventricular cavity was enlarged in 22 patients. SV1 or SV2 + RV5 or RV6 was ≥ 3.5 mV in 29 of the 51 ECGs; total QRS amplitude was ≤ 0.8 mV in each of leads I, II, and III in 10; and the R/S ratio was < 1 in lead V4 in 37. Only 1 of the 51 ECGs met all 3 criteria. In contrast to Goldberger's finding of the triad to be 70% sensitive for severe LV dysfunction, in this study, the triad was found to be only 2% sensitive. The difference is likely due to his patients' having idiopathic dilated cardiomyopathy, whereas those in this study had hypertensive cardiomyopathy with or without ischemia. Also, in this study, 1 specific ECG was used for each patient, whereas Goldberger reviewed all of the patients' ECGs looking for the triad. In conclusion, Goldberger's triad is a sensitive or insensitive marker for severe LV dysfunction depending on the patient population and the number of ECGs reviewed.
authors.affiliation: Section of Cardiology, Department of Medicine, Louisiana State University, Health Sciences Center, New Orleans, Louisiana, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Lopez
authors.forename: Camelia C
authors.initials: CC
authors.lastname: Ilie
authors.forename: D Luke
authors.initials: DL
authors.lastname: Glancy
authors.forename: Roberto E
authors.initials: RE
authors.lastname: Quintal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003971:Diastole; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*