title: Brief reports: plasma ropivacaine concentrations after ultrasound-guided rectus sheath block in patients undergoing lower abdominal surgery.
abstract: A rectus sheath block can provide postoperative analgesia for midline incisions. However, information regarding the pharmacokinetics of local anesthetics used in this block is lacking. In this study, we detail the time course of ropivacaine concentrations after this block. Thirty-nine patients undergoing elective lower abdominal surgery were assigned to 3 groups receiving rectus sheath block with 20 mL of different concentrations of ropivacaine. Peak plasma concentrations were dose dependent, and there were no significant differences in the times to peak plasma concentrations. The present data also suggested a slower absorption kinetics profile for ropivacaine after rectus sheath block than other compartment blocks.
authors.affiliation: Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Japan.
authors.forename: Morito
authors.initials: M
authors.lastname: Wada
authors.forename: Masato
authors.initials: M
authors.lastname: Kitayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kudo
authors.forename: Mihoko
authors.initials: M
authors.lastname: Kudo
authors.forename: Norikazu
authors.initials: N
authors.lastname: Takada
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Hirota
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging / Q000294:innervation / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007267:Injections; D007564:Japan; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010149:Postoperative Pain / Q000517:prevention & control*; D000077212:Ropivacaine; D018084:Ultrasonography, Interventional; D055815:Young Adult
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine