title: Tyrosine phosphorylation and liver regeneration: A glance at intracellular transducers.
abstract: Liver regeneration (LR) is a compensatory growth that occurs in response to resection or injury of the liver aimed at restoring the liver mass and maintaining body homeostasis. The activation of intracellular signaling pathways due to extracellular stimuli mainly reflects a highly coordinated spatial and temporal organization of phosphotyrosine-based signals generated by the concerted action of three basic functional modules, namely protein tyrosine kinases, protein tyrosine phosphatases, and the Src homology 2 (SH2) domain. In this review, we have selected a set of signaling proteins downstream of activated cytokine and growth factor receptors that highlight the multifaceted aspects of tyrosine phosphorylation with their impact on the course of LR. Besides being a process of remarkable biological interest, LR has recently emerged as a model for dissecting molecular mechanisms underlying diverse pathophysiological states, offering new perspectives in primarily, but not only, managing life-threatening liver diseases.
authors.affiliation: Department of Biological Chemistry, University of Padua, Padua, Italy. mario.pagano@unipd.it
authors.forename: Mario Angelo
authors.initials: MA
authors.lastname: Pagano
authors.forename: Elena
authors.initials: E
authors.lastname: Tibaldi
authors.forename: Enrico
authors.initials: E
authors.lastname: Gringeri
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Brunati
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D008115:Liver Regeneration; D019000:Phosphotyrosine / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D019000:Phosphotyrosine; D020794:Receptor Protein-Tyrosine Kinases