title: SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS.
abstract: SPARC-like 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the regulation of processes such as cell migration, proliferation, and differentiation. Here we show that SC1 exhibits remarkably diverse and dynamic expression in the developing and adult nervous system. During development, SC1 localizes to radial glia and pial-derived structures, including the vasculature, choroid plexus, and pial membranes. SC1 is not downregulated in postnatal development, but its expression shifts to distinct time windows in subtypes of glia and neurons, including astrocytes, large projection neurons, Bergmann glia, Schwann cells, and ganglionic satellite cells. In addition, SC1 expression levels and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensate for the absence of SPARC. We conclude that SC1 and SPARC may share significant homology, but are likely to have distinct but complementary roles in nervous system development.
authors.affiliation: Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
authors.forename: Samantha
authors.initials: S
authors.lastname: Lloyd-Burton
authors.forename: A Jane
authors.initials: AJ
authors.lastname: Roskams
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D015676:Osteonectin / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D015676:Osteonectin; C524549:SMOC-1 protein, mouse; C503127:Sparcl1 protein, mouse