title: The role of methyl-binding proteins in chromatin organization and epigenome maintenance.
abstract: Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-binding proteins (MBPs), which belong to three different structural families in mammals: the MBD family, the Kaiso and Kaiso-like proteins and the SRA domain proteins. A current view is that, once bound to methylated DNA, MBPs translate the DNA methylation signal into appropriate functional states, through interactions with diverse partners. However, if some of the biological functions of MBPs have been widely described--notably transcriptional repression--others are poorly understood, and more generally the extent of MBP activities remains unclear. Here we propose to discuss the role of MBPs in two crucial nuclear events: chromatin organization and epigenome maintenance. Finally, important challenges for future research as well as for biomedical applications in pathologies such as cancers--in which DNA methylation patterns are widely altered--will be mentioned.
authors.affiliation: Institut National du Cancer (INCa), CNRS UMR7216/Université Paris Diderot, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Fournier
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sasai
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Nakao
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Defossez
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000378:metabolism*; D018899:CpG Islands; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D044127:Epigenesis, Genetic; D016678:Genome; D006801:Humans
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D004247:DNA