title: Sex-related differences in association of oxidative stress status with coronary artery disease.
abstract: OBJECTIVE
  To assess oxidative stress status in coronary artery disease (CAD) patients according to gender.
  
  
  METHODS
  Case-controlled, observational, retrospective study.
  
  
  METHODS
  Clinical and research center.
  
  
  METHODS
  A total of 55 postmenopausal women and 108 men (mean age: 66 ± 9 years), including 72 patients with angiographically proven CAD (CAD(+), 19 women) and a group of 91 age-matched controls (CAD(-), 36 women).
  
  
  METHODS
  None.
  
  
  METHODS
  Oxidant/antioxidant balance as a global index (oxidative index) obtained using two commercial assays (d-ROMs and OXY Adsorbent Test, respectively) for estimation of levels of reactive oxygen metabolites and total antioxidant status.
  
  
  RESULTS
  There was a statistically significant difference in oxidative stress status between men and women who were CAD(-) (-0.424 ± 1.3 vs. 0.64 ± 1.1 arbitrary units, respectively), but the CAD(+) women had oxidative stress levels almost three times those of the CAD(+) men (2.45 ± 2.5 vs. 0.9 ± 1.6 arbitrary units, respectively). After adjustment in the multivariate model, age and oxidative stress status in women and diabetes and age in men remained as statistically significant predictors of positive CAD findings.
  
  
  CONCLUSIONS
  Oxidative stress status was a powerful predictor of CAD in women. This result may have important implications for the differences between sexes in CAD physiopathology.
authors.affiliation: Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy. cristina.vassalle@ftgm.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Vassalle
authors.forename: Rosalia
authors.initials: R
authors.lastname: Sciarrino
authors.forename: Sara
authors.initials: S
authors.lastname: Bianchi
authors.forename: Debora
authors.initials: D
authors.lastname: Battaglia
authors.forename: Antonella
authors.initials: A
authors.lastname: Mercuri
authors.forename: Silvia
authors.initials: S
authors.lastname: Maffei
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants / Q000032:analysis; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism*; D048909:Diabetes Complications / Q000378:metabolism; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species