title: Osteoarthritis year 2011 in review: biology.
abstract: This review is focused on advances in understanding the biology of joint homeostasis and osteoarthritis (OA) pathogenesis mechanisms that have led to proof of concept studies on new therapeutic approaches. The three selected topics include angiogenesis in joint tissues, biomechanics and joint lubrication and mitochondrial dysfunction. This new information represents progress in the integration of mechanisms that control multiple aspects of OA pathophysiology.
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. mlotz@scripps.edu
authors.forename: M
authors.initials: M
authors.lastname: Lotz
mesh_terms: D001343:Autophagy; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D006820:Hyaluronic Acid / Q000502:physiology; D007596:Joints / Q000098:blood supply; D008928:Mitochondria / Q000473:pathology; D028361:Mitochondrial Diseases / Q000150:complications; D009389:Neovascularization, Pathologic / Q000150:complications; D010003:Osteoarthritis / Q000209:etiology* / Q000503:physiopathology; D000099158:Proteoglycan 4
chemical_list: D006023:Glycoproteins; D006820:Hyaluronic Acid; D000099158:Proteoglycan 4