title: The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filtering.
abstract: Meta-analysis based techniques are emerging as powerful, robust tools for developing models of connectivity in functional neuroimaging. Here, we apply meta-analytic connectivity modeling to the human caudate to 1) develop a model of functional connectivity, 2) determine if meta-analytic methods are sufficiently sensitive to detect behavioral domain specificity within region-specific functional connectivity networks, and 3) compare meta-analytic driven segmentation to structural connectivity parcellation using diffusion tensor imaging. Results demonstrate strong coherence between meta-analytic and data-driven methods. Specifically, we found that behavioral filtering resulted in cognition and emotion related structures and networks primarily localized to the head of the caudate nucleus, while perceptual and action specific regions localized to the body of the caudate, consistent with early models of nonhuman primate histological studies and postmortem studies in humans. Diffusion tensor imaging (DTI) revealed support for meta-analytic connectivity modeling's (MACM) utility in identifying both direct and indirect connectivity. Our results provide further validation of meta-analytic connectivity modeling, while also highlighting an additional potential, namely the extraction of behavioral domain specific functional connectivity.
authors.affiliation: Neuroscience Institute, Scott & White Healthcare, Texas A&M Health Science Center, College of Medicine, Temple, TX 76508, USA. jrobinson@swmail.sw.org
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Robinson
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.forename: David C
authors.initials: DC
authors.lastname: Glahn
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Manjit K
authors.initials: MK
authors.lastname: Sanghera
authors.forename: Luiz
authors.initials: L
authors.lastname: Pessoa
authors.forename: P Mickle
authors.initials: PM
authors.lastname: Fox
authors.forename: Angela
authors.initials: A
authors.lastname: Uecker
authors.forename: Gerhard
authors.initials: G
authors.lastname: Friehs
authors.forename: Keith A
authors.initials: KA
authors.lastname: Young
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Griffin
authors.forename: William R
authors.initials: WR
authors.lastname: Lovallo
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
mesh_terms: D000328:Adult; D001519:Behavior / Q000502:physiology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000033:anatomy & histology* / Q000502:physiology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological