title: Role of interleukin-10 in malaria: focusing on coinfection with lethal and nonlethal murine malaria parasites.
abstract: Interleukin- (IL-) 10, anti-inflammatory cytokine, is known to inhibit the protective immune responses against malaria parasites and to be involved in exacerbating parasitemia during Plasmodium infection. In contrast, IL-10 is regarded as necessary for suppressing severe pathology during Plasmodium infection. Here, we summarize the role of IL-10 during murine malaria infection, focusing especially on coinfection with lethal and nonlethal strains of malaria parasites. Recent studies have demonstrated that the major sources of IL-10 are subpopulations of CD4+ T cells in humans and mice infected with Plasmodium. We also discuss the influence of innate immunity on the induction of CD4+ T cells during murine malaria coinfection.
authors.affiliation: Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Niikura
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Inoue
authors.forename: Fumie
authors.initials: F
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000276:immunology*; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D018512:Parasitemia / Q000276:immunology; D010961:Plasmodium / Q000276:immunology*
chemical_list: C508609:IL10 protein, human; C556062:IL10 protein, mouse; D016753:Interleukin-10