title: Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome.
abstract: Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia-M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corresponding to Klinefelter's syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
authors.affiliation: Hematology clinic, University Hospital, Pleven, Bulgaria;
authors.forename: Vanya
authors.initials: V
authors.lastname: Slavcheva
authors.forename: Tzvetan
authors.initials: T
authors.lastname: Lukanov
authors.forename: Gueorgui
authors.initials: G
authors.lastname: Balatsenko
authors.forename: Svetlana
authors.initials: S
authors.lastname: Angelova
authors.forename: Antonio
authors.initials: A
authors.lastname: Antonov
authors.forename: Lachezar
authors.initials: L
authors.lastname: Bogdanov
authors.forename: Nikolay
authors.initials: N
authors.lastname: Tsvetkov