title: Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water.
abstract: A differential photothermal radiometry method, wavelength-modulated differential photothermal radiometry (WM-DPTR), has been developed theoretically and experimentally for noninvasive, noncontact biological analyte detection, such as blood glucose monitoring. WM-DPTR features analyte specificity and sensitivity by combining laser excitation by two out-of-phase modulated beams at wavelengths near the peak and the base line of a prominent and isolated mid-IR analyte absorption band (here the carbon-oxygen-carbon bond in the pyran ring of the glucose molecule). A theoretical photothermal model of WM-DPTR signal generation and detection has been developed. Simulation results on water-glucose phantoms with the human blood range (0-300 mg/dl) glucose concentration demonstrated high sensitivity and resolution to meet wide clinical detection requirements. The model has also been validated by experimental data of the glucose-water system obtained using WM-DPTR.
authors.affiliation: Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G8.
authors.forename: Andreas
authors.initials: A
authors.lastname: Mandelis
authors.forename: Xinxin
authors.initials: X
authors.lastname: Guo
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003198:Computer Simulation; D005947:Glucose / Q000032:analysis*; D006358:Hot Temperature; D007834:Lasers; D008027:Light; D008956:Models, Chemical; D010783:Photometry / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D005947:Glucose