title: Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells.
authors.forename: M
authors.initials: M
authors.lastname: López-Guerra
authors.forename: S
authors.initials: S
authors.lastname: Xargay-Torrent
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Galán
authors.forename: I
authors.initials: I
authors.lastname: Saborit-Villarroya
authors.forename: L
authors.initials: L
authors.lastname: Rosich
authors.forename: N
authors.initials: N
authors.lastname: Villamor
authors.forename: M
authors.initials: M
authors.lastname: Aymerich
authors.forename: G
authors.initials: G
authors.lastname: Roué
authors.forename: E
authors.initials: E
authors.lastname: Campo
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: D
authors.initials: D
authors.lastname: Colomer
mesh_terms: D001557:Benzenesulfonates / Q000494:pharmacology*; D015153:Blotting, Western; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival; D018925:Chemokines / Q000378:metabolism; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D011947:Receptors, Antigen, B-Cell / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D000077157:Sorafenib; D000072377:Syk Kinase; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment / Q000187:drug effects*; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D001557:Benzenesulfonates; D018925:Chemokines; D047908:Intracellular Signaling Peptides and Proteins; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D012333:RNA, Messenger; D011947:Receptors, Antigen, B-Cell; D009536:Niacinamide; D000077157:Sorafenib; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; D019061:src-Family Kinases