title: Mitoxantrone and etoposide with or without intermediate dose cytarabine for the treatment of primary induction failure or relapsed acute myeloid leukemia.
abstract: Mitoxantrone and etoposide (ME) salvage regimens have been successfully used for the treatment of primary induction failure or relapsed acute myeloid leukemia (AML). Whether the addition of intermediate dose cytarabine to ME increases complete remissions is unknown. To date, these regimens have not been directly compared. Herein, we report the response to treatment with a fixed dosing schedule of ME or MEC in 65 patients treated for primary refractory or relapsed AML with intermediate or unfavorable risk cytogenetics. Differences in CR between ME and MEC subsets were analyzed to determine the effect of cytarabine to ME.
authors.affiliation: Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL 60611, USA. strifili@nmh.org
authors.forename: Steven M
authors.initials: SM
authors.lastname: Trifilio
authors.forename: Alfred W
authors.initials: AW
authors.lastname: Rademaker
authors.forename: Diane
authors.initials: D
authors.lastname: Newman
authors.forename: Katherine
authors.initials: K
authors.lastname: Coyle
authors.forename: Katrin
authors.initials: K
authors.lastname: Carlson-Leuer
authors.forename: Jayesh
authors.initials: J
authors.lastname: Mehta
authors.forename: Jessica
authors.initials: J
authors.lastname: Altman
authors.forename: Olga
authors.initials: O
authors.lastname: Frankfurt
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D003582:Cytogenetics; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D012008:Recurrence; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone