title: Comparison of gastric ulcerogenicity of percolated extract of Anacardium occidentale (cashew nut) with indomethacin in rats.
abstract: In traditional Iranian medicine, the core of the fruit of Anacardium occidentale (cashew nut) has been used in the management of the pain. In this study gastric ulcerogenicity effect of the percolated extract of A. occidentale was investigated in rats. The extract or indomethacin (200, 300, 400 and 800 mg/kg) was administrated orally. In the control group normal saline (5 ml/kg) was used. After getting extract, indomethacin or normal saline, animals were slaughtered. The stomachs were detached and 10ml of 2% formalin injected in to the stomach for fixing the internal coat of the gastric wall. The stomachs were then slitted open near the bigger curvature and lacerations in the glandular part were evaluated. The ulcer index was determined using j-score. Data demonstrated that the oral dose of 200mg/kg of the extract did not provoke any ulcerogenic consequence in the rat's stomach. Gastric ulcerginicity of the extract at the doses of 300, 400 and 800 mg/kg was less than the similar doses of indomethacin (p<0.01).  Therefore, A. occidentale is an appropriate plant for ongoing search for establishing an analgesic agent with low gastro-intestinal side effects for clinical use.
authors.affiliation: Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Effat
authors.initials: E
authors.lastname: Behravan
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Heidari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Heidari
authors.forename: Ghasem
authors.initials: G
authors.lastname: Fatemi
authors.forename: Leila
authors.initials: L
authors.lastname: Etemad
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Taghipour
authors.forename: Mitra
authors.initials: M
authors.lastname: Abbasifard
mesh_terms: D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D007213:Indomethacin / Q000009:adverse effects*; D008297:Male; D008519:Medicine, Traditional / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D007213:Indomethacin