title: Effect of pneumococcal vaccination on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian children.
abstract: The 7-valent pneumococcal conjugate vaccine (PCV7) reduces carriage of vaccine type Streptococcus pneumoniae but leads to replacement by nonvaccine serotypes and may affect carriage of other respiratory pathogens. We investigated nasopharyngeal carriage of S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian infants participating in a pneumococcal vaccine trial using quantitative PCR. Vaccination did not affect pathogen carriage rates or densities, whereas significant differences between the two major ethnic groups were observed.
authors.affiliation: Centre for International Child Healtha and Infectious Diseases & Microbiology, Royal Children’s Hospital, Parkville, VIC, Australia. eileen.dunne@mcri.edu.au
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Dunne
authors.forename: Jayne
authors.initials: J
authors.lastname: Manning
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Russell
authors.forename: Roy M
authors.initials: RM
authors.lastname: Robins-Browne
authors.forename: E Kim
authors.initials: EK
authors.lastname: Mulholland
authors.forename: Catherine
authors.initials: C
authors.lastname: Satzke
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005367:Fiji / Q000453:epidemiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000302:isolation & purification*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D015995:Prevalence; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines