title: Many tumors in one: a daunting therapeutic prospect.
abstract: In this issue of Cancer Cell, Snuderl and coworkers demonstrate intratumoral genetic heterogeneity in glioblastoma based on in situ amplification of distinct genomic loci within individual cells in a mutually exclusive pattern. These findings may herald trouble for current targeted therapies but provide insights for future treatment strategies.
authors.affiliation: Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Chibawanye I
authors.initials: CI
authors.lastname: Ene
authors.forename: Howard A
authors.initials: HA
authors.lastname: Fine