title: Predicting erectile function outcome in men after radical prostatectomy for prostate cancer.
abstract: OBJECTIVE
  • To identify the reported rates of potency after prostatectomy in the recent literature for men without preoperative erectile dysfunction (ED) and to develop a statistical model for predicting the expected potency after prostatectomy.
  
  
  METHODS
  • A Medline search was conducted with the keywords 'potency' and 'prostatectomy' from 2003 to 2009. • In total, 33 studies in the English language reporting pre- and postoperative erectile function were identified. • Data from studies reporting outcome after open, laparoscopic and robot-assisted prostatectomy were analyzed separately. • Only data obtained from potent men before surgery were included in the analysis.
  
  
  RESULTS
  • In potent men before surgery, the main predictors of post-treatment erectile function are age and time after treatment. • The cumulative range of potency rates at 48 months for all ages (45-75 years) was 49-74% for open, 58-74% for laparoscopic and 60-100% for robotic prostatectomy. • The predicted outcome differs by type of operation and patient age.
  
  
  CONCLUSIONS
  • Men aged <60 years have a significant likelihood of regaining erectile function after radical prostatectomy. • The reported statistical model provides a reliable estimation of erectile function outcome after prostatectomy for men with localized prostate cancer and intact erectile function.
authors.affiliation: Institute of Naval Medicine, Alverstoke, UK.
authors.forename: Shaun
authors.initials: S
authors.lastname: Kilminster
authors.forename: Stig
authors.initials: S
authors.lastname: Müller
authors.forename: Mani
authors.initials: M
authors.lastname: Menon
authors.forename: Jean V
authors.initials: JV
authors.lastname: Joseph
authors.forename: David J
authors.initials: DJ
authors.lastname: Ralph
authors.forename: Hiten R H
authors.initials: HR
authors.lastname: Patel
mesh_terms: D000368:Aged; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D011184:Postoperative Period; D057234:Preoperative Period; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods; D011471:Prostatic Neoplasms / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function; D012044:Regression Analysis; D012371:Robotics / Q000379:methods; D016896:Treatment Outcome
chemical_list: D058986:Phosphodiesterase 5 Inhibitors