title: Fosfomycin: efficacy against infections caused by multidrug-resistant bacteria.
abstract: OBJECTIVE
  To analyze the indications for and the efficacy of parenteral fosfomycin, especially against multidrug-resistant (MDR) and pan-resistant bacterial infections.
  
  
  METHODS
  During a unique crisis in fosfomycin production, the supply of this antibiotic had to be carefully monitored in France over a 10-week period. One hundred and sixteen assessable patients were included in a prospective cohort study.
  
  
  RESULTS
  The main indications for use were osteoarthritis, lung infection, urinary tract infection, and bacteraemia. The 2 bacteria most frequently involved were Pseudomonas aeruginosa and methicillin-resistant Staphylococcus. MDR bacteria were seen in 71.5% (83/116) of cases, especially MDR P. aeruginosa (n = 28). Critical situations were common, with 44.0% (51/116) of hospitalizations occurring in an intensive care unit and 22.4% (26/116) of patients with septic shock. The overall outcome was favourable in 76.8% of cases (76/99 assessable patients).
  
  
  CONCLUSIONS
  This study provided a unique opportunity to describe the use of fosfomycin and assess its efficacy, especially against MDR bacterial infections, even in critical situations.
authors.affiliation: Division of Infectious Diseases, AP-HP, Raymond Poincaré University Hospital, Garches, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Dinh
authors.forename: Jérôme
authors.initials: J
authors.lastname: Salomon
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Bru
authors.forename: Louis
authors.initials: L
authors.lastname: Bernard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000494:pharmacology; D005602:France; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin