title: [A study of relationship between obstructive sleep apnea-hypopnea syndrome in hypertension and insulin].
abstract: OBJECTIVE
  To investigate the association between the obstructive sleep apnea-hypopnea syndrome (OSAHS) in hypertension and insulin.
  
  
  METHODS
  A total of 521 patients were divided into 4 groups according to apnea-hypopnea index and OSAHS degrees. The control group (group I), mild OSAHS group (group II), moderate OSAHS group (group III) and severe OSAHS group (group IV) had 89 patients, 194 patients, 118 patients and 120 patients respectively.
  
  
  RESULTS
  The BMI [(30.4 ± 3.8) kg/m(2)], apnea-hypopnea index (AHI, 3.8 ± 0.1), Fasting insulin (FIns) [(3.08 ± 0.26) mU/L] and insulin resistance (2.43 ± 0.27) of patients in severe OSAHS group were significantly higher than that of in the control, mild OSAHS group and moderate OSAHS group (P < 0.01). The levels of saturation of minimum oxygen from skin of patients in severe OSAHS group was significantly lower (MSpO(2)) than in that of the control, mild OSAHS group and moderate OSAHS group. Multiple linear regression analysis showed that fasting plasma insulin and insulin resistance was positive correlation with apnea-hypopnea index, while they also negatively associated with saturation of minimum oxygen.
  
  
  CONCLUSIONS
  FIns and insulin resistance strongly associate with AHI and levels of saturation of minimum oxygen from skin. Hypertensive patients with OSAHS have more chances to suffer with insulin resistance.
authors.affiliation: Center of Hypertension, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
authors.forename: Yun-wei
authors.initials: YW
authors.lastname: Bi
authors.forename: Zhi-tao
authors.initials: ZT
authors.lastname: Yan
authors.forename: Nan-fang
authors.initials: NF
authors.lastname: Li
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Cheng
authors.forename: Rui-mei
authors.initials: RM
authors.lastname: Han
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zhang
authors.forename: Ying-chun
authors.initials: YC
authors.lastname: Wang
authors.forename: Xin-ling
authors.initials: XL
authors.lastname: Wang
authors.forename: Fei-ya
authors.initials: FY
authors.lastname: Zu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications* / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010100:Oxygen