title: The neurotoxic potential of engineered nanomaterials.
abstract: The expanding development and production of engineered nanomaterials (ENMs) have diverse and far-reaching potential benefits in consumer products, food, drugs, medical devices and for enhancing environmental cleanup and remediation. The knowledge of potential implications of ENMs, including the potential for inadvertent exposures and adverse neurotoxic consequences, is lagging behind their development. A potential risk for neurotoxicity arises if exposure leads to systemic absorption and distribution to the nervous system. This paper is the summary of a symposium entitled Neurotoxicity Potential of Engineered Nanomaterials presented at the 2011 Xi'an International Neurotoxicology Conference held June 5-9 in Xi'an China. The following topics were featured in the symposium: the toxicokinetics of engineered nanomaterials; differential uptake of nanoceria in brain and peripheral organs; translocation into the brain and potential damage following nanoparticle exposure; and the retina as a potential site of nanomaterial phototoxicity. Each of these topics is discussed fully in sections of the manuscript. The promising benefits of ENM technology can be best realized if the potential risks are first understood and then minimized in product and system designs.
authors.affiliation: US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. boyes.william@epa.gov
authors.forename: William K
authors.initials: WK
authors.lastname: Boyes
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.forename: Robert A
authors.initials: RA
authors.lastname: Yokel
mesh_terms: D001711:Biotransformation; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D049329:Nanostructures / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012160:Retina / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors; D014018:Tissue Distribution; D014116:Toxicology / Q000379:methods; D014781:Viscera / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D004785:Environmental Pollutants