title: Subventricular zone under the neuroinflammatory stress and Parkinson's disease.
abstract: This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.
authors.affiliation: Department of Physiology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Mori
authors.forename: Yoko S
authors.initials: YS
authors.lastname: Kaneko
authors.forename: Akira
authors.initials: A
authors.lastname: Nakashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagasaki
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Nagatsu
authors.forename: Ikuko
authors.initials: I
authors.lastname: Nagatsu
authors.forename: Akira
authors.initials: A
authors.lastname: Ota
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D009420:Nervous System / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology*; D015398:Signal Transduction; D013312:Stress, Physiological