title: Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage.
abstract: OBJECTIVE
  Cerebro-spinal fluid (CSF) leakage caused by defects on the dura mater     after trauma or some neurosurgical interventions is an important issue. In this     study, we investigated the effects of local and systemic use of phenytoin sodium     on dural healing.
  
  
  METHODS
  Thirty-six male Wistar rats were divided     into control, local phenytoin and systemic phenytoin groups with 12 rats in     each. For each group, a dura defect was created at thoracic segment. Subjects     were sacrificed at following 1st and 6th weeks and damaged segments were     isolated. The results were compared histopathologically by Hematoxylin-Eosin and     Masson-Trichrome staining. Criteria for the rate of collagen,     neovascularization, and granulation formation were assessed semi quantitatively     according to the histological assessment scale modified by Ozisik et al.
  
  
  RESULTS
  Better healing was achieved in the systemic and local phenytoin groups     than in the control group. The level of healing was significantly higher in the     systemic group in both early and late periods than in other groups (p <     0.01). The level of healing in the late-local group was also statistically     significantly higher than that in the control group.
  
  
  CONCLUSIONS
  We observed     that both systemic and local uses of phenytoin sodium (especially systemic) have     positive effects on dura healing.
authors.affiliation: Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Ergun
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tonge
authors.forename: Hamit
authors.initials: H
authors.lastname: Aytar
authors.forename: Murat
authors.initials: M
authors.lastname: Tas
authors.forename: Kemali
authors.initials: K
authors.lastname: Baykaner
authors.forename: Necdet
authors.initials: N
authors.lastname: Ceviker
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004388:Dura Mater / Q000293:injuries* / Q000378:metabolism / Q000601:surgery; D006097:Granulation Tissue / Q000187:drug effects; D008297:Male; D019635:Neurosurgical Procedures; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin