title: [A case of pathological complete response after treatment with uracil/tegafur (UFT) and folinate (Leucovorin) for liver metastasis of colon cancer].
abstract: The patient is a 62-year-old female who underwent a right hemicolectomy for type-2 ascending colon cancer (moderately-differentiated adenocarcinoma, ss, n0, H0, P0, M0, stage II). Six months after the surgery, a solitary metastatic focus was expressed in the liver S3. Because schizophrenia was present concurrently, tegafur and uracil/folinate (UFT/Leucovorin) treatment was selected and performed for 3 months. Because the tumor shrank afterward, a partial hepatectomy was performed to obtain a curative resection. In a pathological examination of the resected focus, cicatricial/necrotic findings were observed, but no cancer cells were observed; hence, it was determined to be a pathological complete response (CR). In regard to chemotherapy for distant metastasis of colorectal cancer, many molecular-targeted agents are being introduced, thus resulting in more treatment options; however, depending on the patient's background, UFT/LV treatment can be an effective treatment option.
authors.affiliation: Dept. of Surgery, Kitakyushu General Hospital.
authors.forename: Ryouta
authors.initials: R
authors.lastname: Murayama
authors.forename: Naoki
authors.initials: N
authors.lastname: Nagata
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Honda
authors.forename: Mio
authors.initials: M
authors.lastname: Fujii
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sawatsubashi
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Shinohara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Sako
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Hayato
authors.initials: H
authors.lastname: Sanefuji
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D012074:Remission Induction; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use; D014498:Uracil / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin