title: "Reported, but still unknown." A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles.
abstract: Straightforward practical synthetic approaches to 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles have been developed. The key step of the both syntheses is a transformation of the carboxylic group in a pyrazole core into the trifluoromethyl group by sulfur tetrafluoride. The elaborated synthetic protocols allow gram-scale preparation of the target products. The obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pK(a) values and fluorescence measurements.
authors.affiliation: Enamine Ltd., Oleksandra Matrosova Street, 23, Kyiv 01103, Ukraine. igerus@hotmail.com
authors.forename: Igor I
authors.initials: II
authors.lastname: Gerus
authors.forename: Roman X
authors.initials: RX
authors.lastname: Mironetz
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Kondratov
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Bezdudny
authors.forename: Yurii V
authors.initials: YV
authors.lastname: Dmytriv
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Shishkin
authors.forename: Viktoriia S
authors.initials: VS
authors.lastname: Starova
authors.forename: Olga A
authors.initials: OA
authors.lastname: Zaporozhets
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachev
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk
mesh_terms: D018360:Crystallography, X-Ray; D006845:Hydrocarbons, Fluorinated; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: C572511:3,4,5-tris(trifluoromethyl)pyrazole; C572512:3,4-tris(difluoromethyl)pyrazole; D006845:Hydrocarbons, Fluorinated; D011720:Pyrazoles