title: The key to halting progression of CKD might be in the produce market, not in the pharmacy.
abstract: In vitro, experimental, and clinical work suggests that metabolic acidosis, either directly or indirectly, can promote the progression of chronic kidney disease (CKD). Goraya et al. demonstrate that both oral alkali supplementation and a diet rich in fruits and vegetables are equally effective at decreasing urinary excretion of markers of renal injury in patients with stage 2 CKD. Although this study is promising, the short duration and use of only urinary markers as a surrogate outcome weaken the conclusions.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. jaime.uribarri@mssm.edu
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
authors.forename: Man S
authors.initials: MS
authors.lastname: Oh
mesh_terms: D000143:Acids / Q000037:antagonists & inhibitors*; D004032:Diet; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000178:diet therapy* / Q000209:etiology*; D008297:Male
chemical_list: D000143:Acids