title: The bioactivated interfacial behavior of the fluoridated hydroxyapatite-coated mg-zn alloy in cell culture environments.
abstract: A partially fluorine substituted hydroxyapatite- (FHA-) coated Mg-Zn alloy was prepared to investigate the interfacial behavior of degradable Mg-based biomaterials with degradable bioactive coatings in a cell culture environment. Peaks from the results of X-ray diffraction (XRD) were characterized and compared before and after cell culture. It was found that Ca-P, including poorly crystalline ion-substituted Ca-deficient HA (CDHA), was formed in greater amounts on the interface of coated samples compared with the uncoated ones. A thermodynamic mechanism for Ca-P formation on biodegradable Mg alloys in a cell culture environment is proposed. Combined with improved cell calcification, the-FHA coated Mg alloys have the ability to promote CDHA formation, as expected thermodynamically. It is suggested that the specific cell culture environment and the bone-like FHA coatings together facilitate the observed behavior. Moreover, cell culture environment probably increased the biomineralization to a detectable level by affecting the kinetics of apatite formation.
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Zhang
authors.forename: Changli
authors.initials: C
authors.lastname: Zhao
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiaonong
authors.initials: X
authors.lastname: Zhang