title: Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries.
abstract: BACKGROUND
  Recently, the microRNA miR-423_5p was identified as a biomarker for left ventricular heart failure. Its role in patients with a systemic right ventricle and reduced ejection fraction after atrial repair for transposition of the great arteries has not been evaluated.
  
  
  METHODS
  In 41 patients and 10 age- and sex-matched healthy controls circulating miR-423_5p concentration was measured and correlated to clinical parameters, cardiac functional parameters assessed by magnetic resonance imaging, and cardiopulmonary exercise testing.
  
  
  RESULTS
  Levels of circulating miR-423_5p showed no difference between patients and controls. Further, there was no correlation between miR-423_5p and parameters of cardiopulmonary exercise testing or imaging findings.
  
  
  CONCLUSIONS
  In patients with a systemic right ventricle and reduced ejection fraction miR-423_5p levels are not elevated. Therefore, circulating miR-423_5p is not a useful biomarker for heart failure in this patient group.
authors.affiliation: Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. otutarel@hotmail.com
authors.forename: Oktay
authors.initials: O
authors.lastname: Tutarel
authors.forename: Seema
authors.initials: S
authors.lastname: Dangwal
authors.forename: Julia
authors.initials: J
authors.lastname: Bretthauer
authors.forename: Mechthild
authors.initials: M
authors.lastname: Westhoff-Bleck
authors.forename: Philipp
authors.initials: P
authors.lastname: Roentgen
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Anker
authors.forename: Johann
authors.initials: J
authors.lastname: Bauersachs
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000502:physiology; D014188:Transposition of Great Vessels / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D015415:Biomarkers; C548900:MIRN423 microRNA, human; D035683:MicroRNAs