title: Intrapulmonary lipopolysaccharide exposure upregulates cytokine expression in the neonatal brainstem.
abstract: Perinatal inflammation and neonatal sepsis trigger lung and brain injury. We hypothesized that endotoxin exposure in the immature lung upregulates proinflammatory cytokine expression in the brainstem and impairs respiratory control. Lipopolysaccharide (LPS) or saline was administered intratracheally to vagal intact or denervated rat pups. LPS increased brainstem IL-1β and vagotomy blunted this response. There was an attenuated ventilatory response to hypoxia and increased brainstem IL-1β expression after LPS.
  
  
  CONCLUSIONS
  Intratracheal endotoxin exposure in rat pups is associated with upregulation of IL-1β in the brainstem that is vagally mediated and associated with an impaired hypoxic ventilatory response.
authors.affiliation: Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106-6010, USA.
authors.forename: Kannan V
authors.initials: KV
authors.lastname: Balan
authors.forename: Prabha
authors.initials: P
authors.lastname: Kc
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Mayer
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Wilson
authors.forename: Abdelmadjid
authors.initials: A
authors.lastname: Belkadi
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Martin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D053583:Interleukin-1beta / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D014132:Trachea; D015854:Up-Regulation / Q000187:drug effects*; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D053583:Interleukin-1beta; D008070:Lipopolysaccharides