title: Screening of α-glucosidase inhibitory activity from some plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae.
abstract: Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2 DM is more common in diabetic populations. In this type of DM, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the α-glucosidase inhibitor. In this study, we determine the α-glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the α-glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC(50) 117.20 μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC(50) values in the range 2.33-112.02 μg/mL.
authors.affiliation: Department of Pharmacy, Faculty of Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia. elya64@yahoo.com
authors.forename: Berna
authors.initials: B
authors.lastname: Elya
authors.forename: Katrin
authors.initials: K
authors.lastname: Basah
authors.forename: Abdul
authors.initials: A
authors.lastname: Mun'im
authors.forename: Wulan
authors.initials: W
authors.lastname: Yuliastuti
authors.forename: Anastasia
authors.initials: A
authors.lastname: Bangun
authors.forename: Eva Kurnia
authors.initials: EK
authors.lastname: Septiana
mesh_terms: D028084:Clusiaceae / Q000737:chemistry*; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D019684:Magnoliopsida / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D029701:Saccharomyces cerevisiae Proteins; D000431:Ethanol