title: The Munich-LTX-Score: predictor for survival after lung transplantation.
abstract: BACKGROUND
  The purpose of this study was to create a prognostic score calculated one yr after LTX based on post-transplant factors inclusive of donor and recipient characteristics that could be used to predict long-term survival in patients after lung transplantation (LTX).
  
  
  METHODS
  Uni- and multivariate analysis in 206 consecutive LTX patients identified independent risk factors for post-transplant mortality and onset of bronchiolitis obliterans syndrome. Munich-LTX-Score is devised by summing up each identified risk factor.
  
  
  RESULTS
  Multivariate analyses revealed acute rejection, lymphocytic bronchiolitis, donor age ≥ 55 yr, and HLA-A ≥ 2-/DR ≥ 2 mismatch and single LTX to be independent negative predictors for long-term survival (p < 0.05). Munich-LTX-Score identified three discrete groups: low-, moderate-, and high risk. The actuarial five-yr survival after score calculation one yr after LTX of the entire cohort was 58%, compared with 91% in low-, 54% in moderate-, and 0% in the high-risk group (p < 0.001).
  
  
  CONCLUSIONS
  Within our cohort of patients calculation of the Munich-LTX-Score, consisting of donor-, recipient-, and post-transplant characteristics, one yr after LTX allowed to predict long-term survival of lung transplant recipients. After prospective validation, this score could identify patients who may benefit from intensified surveillance after LTX.
authors.affiliation: Department of Internal Medicine I, Division of Pulmonary Diseases, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany. patrick.huppmann@gmx.de
authors.forename: Patrick
authors.initials: P
authors.lastname: Huppmann
authors.forename: Claus
authors.initials: C
authors.lastname: Neurohr
authors.forename: Stefan
authors.initials: S
authors.lastname: Leuschner
authors.forename: Hanno
authors.initials: H
authors.lastname: Leuchte
authors.forename: Rainer
authors.initials: R
authors.lastname: Baumgartner
authors.forename: Gregor
authors.initials: G
authors.lastname: Zimmermann
authors.forename: Tobias
authors.initials: T
authors.lastname: Meis
authors.forename: Werner
authors.initials: W
authors.lastname: von Wulffen
authors.forename: Peter
authors.initials: P
authors.lastname: Überfuhr
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hatz
authors.forename: Lorenz
authors.initials: L
authors.lastname: Frey
authors.forename: Jürgen
authors.initials: J
authors.lastname: Behr
mesh_terms: D000293:Adolescent; D000328:Adult; D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000401:mortality*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology* / Q000401:mortality*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult