title: Oral and dental health status in patients with primary antibody deficiencies.
abstract: Primary antibody deficiencies (PAD) are a group of immune system disorders, associated with decreased levels of secretory and protective immunoglobulins. Because of the important role of immunoglobulins in the protection of oral cavity, patients with PADs are more susceptible to dental caries or oral manifestations. This study was performed to investigate the oral and dental manifestations of PADs patients. In this study, 33 patients with PADs (21 common variable immunodeficiency, 8 X-linked agammaglobulinemia and 4 hyper IgM syndrome) and 66 controls were examined; the number of decayed, missed and filled teeth (DMFT) were investigated. Aphthous was the most frequent manifestation in PADs patients (38.7%), which was significantly 16.7% higher than the controls (p=0.03). The patients with PADs showed significantly higher presentation of other oral and dental manifestations, including herpes sores, candidiasis tonsillitis, gingivitis, calculus, enamel hypoplasia and other ulcerations. The mean DMFT scores were 6.15±3.6 and 1.93±0.4 in PADs patients and controls, respectively (p<0.001). Although the patients with common variable immunodeficiency had higher means of DMFT in comparison with other groups of PADs, this difference was not statistically significant. This study showed significantly higher frequency of oral and dental manifestations in the patients with PADs compared to controls. Therefore, regular examination of oral cavity could be suggested in this group of immunodeficient patients.
authors.affiliation: Research Center for Immunodeficiencies, Children's Medical Center, Tehran, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Meighani
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
authors.forename: Honarmand
authors.initials: H
authors.lastname: Javanbakht
authors.forename: Hassan
authors.initials: H
authors.lastname: Abolhassani
authors.forename: Sina
authors.initials: S
authors.lastname: Nikayin
authors.forename: Seyed Mehryar
authors.initials: SM
authors.lastname: Jafari
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ghandehari Motlagh
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Shamshiri
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006304:Health Status; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology*; D009909:Oral Health; D014076:Tooth Diseases / Q000453:epidemiology*