title: The search for effective therapy for sepsis: back to the drawing board?
authors.affiliation: Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, 604 Scaife Hall, Pittsburgh, PA 15261, USA. angusdc@upmc.edu
authors.forename: Derek C
authors.initials: DC
authors.lastname: Angus
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004187:Disaccharides / Q000627:therapeutic use; D055808:Drug Discovery; D006801:Humans; D007108:Immune Tolerance; D007239:Infections / Q000150:complications; D023421:Models, Animal; D018579:Patient Selection; D011486:Protein C / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D013403:Sugar Phosphates / Q000627:therapeutic use; D051197:Toll-Like Receptor 4 / Q000037:antagonists & inhibitors; D017211:Treatment Failure
chemical_list: D000890:Anti-Infective Agents; D004187:Disaccharides; D011486:Protein C; D011994:Recombinant Proteins; D013403:Sugar Phosphates; D051197:Toll-Like Receptor 4; C512420:eritoran; C421124:drotrecogin alfa activated