title: An MRI study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia.
abstract: Septum pellucidum (SP) and cavum SP (CSP) were delineated in two samples. The Longitudinal Study examined structural MR-images in first-episode schizophrenia (FESZ) and controls at two time-points. The Cross-Sectional Study examined structural and diffusion-tensor MR measures, including hippocampus and fornix, in chronic schizophrenia (SZ) at one time-point. CSP and SP measurements remained stable over time in FESZ and controls. Compared to controls, CSP were smaller in FESZ, but not in chronic SZ. SP were larger in chronic SZ, but not in FESZ. In chronic SZ only, SP-Length was correlated negatively with fornix-FA and hippocampal volume, and positively with chlorpromazine-equivalent dosage.
authors.affiliation: Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St., Boston, MA 02215, United States.
authors.forename: Charlie A
authors.initials: CA
authors.lastname: Davidson
authors.forename: Noriomi
authors.initials: N
authors.lastname: Kuroki
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alvarado
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Niznikiewicz
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
authors.forename: James J
authors.initials: JJ
authors.lastname: Levitt
mesh_terms: D000328:Adult; D016880:Anisotropy; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D020712:Fornix, Brain / Q000187:drug effects / Q000473:pathology*; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology*; D012688:Septum Pellucidum / Q000187:drug effects / Q000473:pathology*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine