title: Organocatalytic enantioselective conjugate addition of ketones to isatylidine malononitriles.
abstract: An enantioselective Michael addition of ketones to alkylidenemalononitriles catalyzed by chiral primary amine I with (R)-5c as a co-catalyst in good yields (>90%) and with good enantioselectivities (85-96% ee) has been developed. The strategy has also been extended to a three-component version through a domino Knoevenagel/Michael sequence with similar or better outcomes.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Deyan
authors.initials: D
authors.lastname: Wu
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.forename: Sinan
authors.initials: S
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D009570:Nitriles