title: Regulation and function of innate and adaptive interleukin-17-producing cells.
abstract: Interleukin-17 (IL-17)-mediated immune responses play a crucial role in the mucosal                 host defence against microbial and fungal pathogens. However, the chronic activation                 of IL-17-producing T helper cells can cause autoimmune disease. In addition, recent                 studies have highlighted key roles of innate cell-mediated IL-17 responses in                 various inflammatory settings. Besides inflammation, there have also been intriguing                 findings regarding the involvement of IL-17 responses in the pathogenesis of                 cardiovascular diseases and tumour formation. Here, we discuss the latest                 discoveries in regulation and function of innate and adaptive IL-17-producing                 cells.
authors.affiliation: MRC National Institute for Medical Research, Division of Molecular Immunology, Mill Hill, London NW7 1AA, UK. khirota@nimr.mrc.ac.uk
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirota
authors.forename: Helena
authors.initials: H
authors.lastname: Ahlfors
authors.forename: João H
authors.initials: JH
authors.lastname: Duarte
authors.forename: Brigitta
authors.initials: B
authors.lastname: Stockinger
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D020381:Interleukin-17 / Q000096:biosynthesis*; D018448:Models, Immunological; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D020381:Interleukin-17