title: Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects.
abstract: Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). Forty-five cognitive normal ApoE ε4 allele carriers and 45 noncarriers underwent both FDG positron emission tomography and magnetic resonance imaging (MRI). A total of 90 normal database sets were generated for the individual 45 ε4 carriers and 45 noncarriers. Mean z-scores in the predefined AD-specific regions of interest (ROI) were calculated for each ε4 carrier and noncarrier using the individually defined normal database. The prevalence of AD-like hypometabolism and atrophy in the ε4 carriers was 8.9% and 17.7%, respectively, and did not differ significantly from those in the noncarriers (8.9%, 8.8%). The majority of ε4 carriers showed preserved FDG uptake or gray matter concentration.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan. kimiharu@med.kanazawa-u.ac.jp
authors.forename: Miharu
authors.initials: M
authors.lastname: Samuraki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsunari
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Chen
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yanase
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism*; D053327:Apolipoprotein E4 / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D055815:Young Adult
chemical_list: D053327:Apolipoprotein E4; D019788:Fluorodeoxyglucose F18; D005947:Glucose