title: Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: review of 2 cases with chromosome 1p/19q and IDH1 analysis.
abstract: Dysembryoplastic neuroepithelial tumor (DNT)-like neoplasms of the septum pellucidum are extremely rare. We reviewed 2 cases of DNT-like neoplasm of the septum pellucidum and specifically studied the immunohistochemical features and chromosomes 1p and 19q deletions. One case was a 26-year-old woman who complained of aggravated headache for 2 weeks. The other case was a 31-year-old female presenting with double vision for a month. Histological examinations showed that the lesions were composed of uniform oligodendrocytelike cells (OLCs) with obvious floating neurons in a mucin-rich background. Immunohistochemical studies revealed that both tumors were diffusely positive for Synaptophysin and Olig2. Sporadic neurons were clearly positive for NeuN. Loss of chromosome 1p/19q and isocitrate dehydrogenase 1(IDH1) mutations were not identified in both cases. It might indicate that these OLCs of DNT-like neoplasms were genetically different from glial tumors, although they showed close morphological similarities.
authors.affiliation: Department of Neuropathology, Institute of Neurology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xiong
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Chu
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation; D018302:Neoplasms, Neuroepithelial / Q000235:genetics / Q000473:pathology*; D012688:Septum Pellucidum / Q000473:pathology*
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human