title: Malignant tumours of colon and rectum from the blood clotting view.
abstract: OBJECTIVE
  The relationship between malignant tumours and blood coagulation disorders is generally well known.
  
  
  BACKGROUND
  The authors notice blood coagulation in patients with colorectal cancer and evaluate prothrombotic markers.
  
  
  METHODS
  The authors analyzed a group of 137 patients with malignant tumour of colon and rectum, drew attention to the relationship between level of D-dimer, PAI-1, F 1+2, Protein C and the progress of malignant tumour, its localization, clinical stage, histopathology type, method of surgery considering the stapling use.
  
  
  RESULTS
  Very aggressive and advance tumours have high level of D dimer, plasminogen activator inhibitor I (PAI-1). Prothrombotic fragments 1+2 were significantly higher by anastomotic dehiscence. Protein C level was lower by age from sixty to seventy and in advanced clinical stage.
  
  
  CONCLUSIONS
  Pre-operative surveys of D dimer, PAI-1, prothrombotic fragments and Protein C give informations abaout risk of thrombosis, far gone of malignant diseases, they clinical stage and histological type. D dimer and PAI-1 have the most clinical value (Fig. 5, Ref. 11).
authors.affiliation: Clinic of Surgery, Faculty hospital JA Reimans, Presov, Slovakia. mytnik@fnsppresov.sk. mytnik@fnsppresov.sk
authors.forename: M
authors.initials: M
authors.lastname: Mytnik
authors.forename: J
authors.initials: J
authors.lastname: Stasko
authors.forename: D
authors.initials: D
authors.lastname: Mistuna
authors.forename: P
authors.initials: P
authors.lastname: Seliga
mesh_terms: D000368:Aged; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011486:Protein C / Q000032:analysis; D011516:Prothrombin
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; D011516:Prothrombin