title: Prevention of preterm labour: 2011 update on tocolysis.
abstract: The aim of this paper is to review available data about drugs for preventing preterm labour. Tocolytic therapy includes β adrenergic receptor agonists, NO donors, magnesium sulphate, prostaglandin-synthase inhibitors, oxytocin receptor antagonists, calcium-channel blockers, progesterone, 17-α-hydroxyprogesterone caproate, and antibiotics. Their specific effects on myometrial contractility, their safety, their efficiency, and side effects profile for the mother and the fetus are presented. The main question of why and for what reasons tocolysis should be administrated is discussed.
authors.affiliation: Department of Obstetrics, Saint-Luc University Hospital, 10 Avenue Hippocrate, 1200 Bruxelles, Belgium. corinne.hubinont@uclouvain.be
authors.forename: C
authors.initials: C
authors.lastname: Hubinont
authors.forename: F
authors.initials: F
authors.lastname: Debieve
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D008278:Magnesium Sulfate / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use; D018045:Receptors, Oxytocin / Q000037:antagonists & inhibitors; D015145:Tocolysis; D015149:Tocolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000318:Adrenergic beta-Agonists; D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D016861:Cyclooxygenase Inhibitors; D006908:Hydroxyprogesterones; D018045:Receptors, Oxytocin; D015149:Tocolytic Agents; D000077713:17 alpha-Hydroxyprogesterone Caproate; D011374:Progesterone; D008278:Magnesium Sulfate