title: Quantification of glistenings in intraocular lenses using a ballistic-photon removing integrating-sphere method.
abstract: An alternative method for quantification of glistenings in intraocular lenses (IOLs) using an integrating sphere with an adjustable back aperture to remove ballistic photons is presented. Glistenings in soft IOLs have been known for more than a decade; however, their severity and visual impact are still under investigation. A number of studies have been made to quantitatively describe glistenings in IOLs. Quantization and precise grading of IOLs will provide needed information to evaluate the severity and visual impact of glistenings in patients. We investigated the use of a simple modification of an integrating-sphere method to eliminate ballistic photons to quantitatively measure scattered light from glistenings in IOLs. The method described in this paper provides a simple and effective way to quantitatively characterize glistenings in vitro. It may be especially useful to quantify scattering associated with low-grade glistenings where the density of the scattering centers is low. Finally, the modified integrating-sphere method may also be generally applicable to quantitatively characterize scattering from other optical media.
authors.affiliation: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. do‐hyun.kim@fda.hhs.gov
authors.forename: Do-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Robert H
authors.initials: RH
authors.lastname: James
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Landry
authors.forename: Don
authors.initials: D
authors.lastname: Calogero
authors.forename: James
authors.initials: J
authors.lastname: Anderson
authors.forename: Ilko K
authors.initials: IK
authors.lastname: Ilev
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007834:Lasers; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D055620:Optical Phenomena; D018918:Phacoemulsification; D017785:Photons; D012542:Scattering, Radiation; D014792:Visual Acuity