title: Surmounting chemoresistance by targeting the Y-box binding protein-1.
abstract: The Y-box binding protein 1 (YB-1), characterized by the presence of the cold shock domain, has been reported to induce chemoresistance in cancer therapy. Chemotherapy is one of the main therapeutic strategies in the treatment of cancer, in addition to surgery, radiation therapy, and hormonal therapy. However, chemoresistance remains a key obstacle to successful cancer management. In this review, we will focus on the role of YB-1, an important regulator of gene transcription, in cancer therapy and chemoresistance.
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Inoue
authors.forename: Ken
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Yu
authors.forename: Boon-Huat
authors.initials: BH
authors.lastname: Bay
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015536:Down-Regulation; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D018390:Gene Targeting; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D051840:Y-Box-Binding Protein 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human