title: Critical choices for modeling breast cancer in transgenic mouse models.
abstract: Modeling breast cancer in the mouse has helped to better define the heterogeneity of human breast cancer. In the recent past, it has become evident that some limitations have restricted the potential benefits that can be achieved with this approach. In this review, we highlight some key points that should be taken into account when the mouse is used, with special emphasis on transgenic models.
authors.affiliation: Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
authors.forename: Isabella
authors.initials: I
authors.lastname: Caligiuri
authors.forename: Flavio
authors.initials: F
authors.lastname: Rizzolio
authors.forename: Silvia
authors.initials: S
authors.lastname: Boffo
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Toffoli
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics* / Q000378:metabolism; D059016:Tumor Microenvironment