title: NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi.
abstract: OBJECTIVE
  Near infrared and impedance spectroscopy can be used for clinical skin measurements and need to be evaluated for possible confounding factors; (i) are skin conditions of the patient and the subsequent skin measurements influenced by alcohol and/or coffee consumption and (ii) are measurements of dysplastic naevi (DN) reproducible over time and significantly different compared to reference skin.
  
  
  METHODS
  Near infrared and skin impedance spectroscopic data were analysed multivariately. In the first study, the skin characteristics of 15 healthy individuals were examined related to body location, gender, individual differences, and consumption of coffee or alcohol. The second study included five patients diagnosed with dysplastic naevi syndrome. Measurements were taken on DN and reference skin over time.
  
  
  RESULTS
  In the first study, body location and gender had a major influence on measurement scores. Inter-individual skin characteristics and coffee or alcohol effects on skin characteristics were of minor importance. In the second study, it was shown that DN can be differentiated from reference skin and the measurements are stable over time.
  
  
  CONCLUSIONS
  Moderate consumption of alcohol and coffee did not influence the results of the measurements. It is possible to follow, stable or changed, characteristics of DN over time.
authors.affiliation: Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.
authors.forename: Ida
authors.initials: I
authors.lastname: Bodén
authors.forename: Josefina
authors.initials: J
authors.lastname: Nyström
authors.forename: Paul
authors.initials: P
authors.lastname: Geladi
authors.forename: Peter
authors.initials: P
authors.lastname: Naredi
authors.forename: Britta
authors.initials: B
authors.lastname: Lindholm-Sethson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003069:Coffee; D004416:Dysplastic Nevus Syndrome / Q000503:physiopathology*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D010992:Plethysmography, Impedance / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D055815:Young Adult
chemical_list: D003069:Coffee; D000431:Ethanol