title: MiR-19b-1 inhibits angiogenesis by blocking cell cycle progression of endothelial cells.
abstract: MicroRNAs are endogenously expressed small, non-coding RNAs that modulate biological processes by recognizing specific gene transcripts, leading to translational repression or degradation. Previous work showed that the miR-17-92 cluster is highly expressed in human endothelial cells that participate in angiogenesis. In this study we showed that miR-19b-1, a component of this cluster, controls the intrinsic angiogenic activity of human umbilical vein endothelial cells (HUVECs) in vitro. In silico and in vitro analyses have suggested that miR-19b-1 targets mRNA corresponding to the pro-angiogenic protein, FGFR2, and blocks the cell cycle from the S phase to the G(2)/M phase transition by controlling the expression of cyclin D1. Thus, miR-19b-1 may serve as a valuable therapeutic agent in the context of tumor angiogenesis.
authors.affiliation: Pharmaceutical Research Center, School of Chemistry & Chemical Engineering, Southeast University, Nanjing 211189, China.
authors.forename: Runting
authors.initials: R
authors.lastname: Yin
authors.forename: Weiwei
authors.initials: W
authors.lastname: Bao
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xing
authors.forename: Tao
authors.initials: T
authors.lastname: Xi
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gou
mesh_terms: D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000502:physiology*; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics
chemical_list: C549214:MIRN19A microRNA, human; D035683:MicroRNAs; C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2