title: Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.
abstract: A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.
authors.affiliation: Laboratoire Synthèse et Réactivité des Substances Naturelles, Poitiers Cedex, France.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Agnès
authors.initials: A
authors.lastname: Martin-Mingot
authors.forename: F
authors.initials: F
authors.lastname: Lecornué
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Jouannetaud
authors.forename: Alfonso
authors.initials: A
authors.lastname: Maresca
authors.forename: Sebastien
authors.initials: S
authors.lastname: Thibaudeau
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000965:Antimony / Q000737:chemistry*; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D002256:Carbonic Anhydrases / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D054879:Halogenation; D006801:Humans; D006858:Hydrofluoric Acid / Q000737:chemistry*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012996:Solutions; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D009363:Neoplasm Proteins; D012996:Solutions; D013449:Sulfonamides; C529140:antimony pentafluoride; D000965:Antimony; D002256:Carbonic Anhydrases; D005459:Fluorides; D006858:Hydrofluoric Acid