title: The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.
authors.affiliation: LRCMB, National Eye Institute, NIH, Bldg 6, Room, 6 Center Dr. MSC0608, Bethesda, MD 20892, USA.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Poliakov
authors.forename: Alexander
authors.initials: A
authors.lastname: Gubin
authors.forename: James
authors.initials: J
authors.lastname: Laird
authors.forename: Susan
authors.initials: S
authors.lastname: Gentleman
authors.forename: Robert G
authors.initials: RG
authors.lastname: Salomon
authors.forename: T Michael
authors.initials: TM
authors.lastname: Redmond
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000633:toxicity; D001667:Binding, Competitive / Q000187:drug effects; D020134:Catalytic Domain / Q000187:drug effects; D003623:Dark Adaptation / Q000187:drug effects*; D017313:Fenretinide / Q000633:toxicity*; D051379:Mice; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000235:genetics; D016254:Mutagenesis, Insertional; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012172:Retinaldehyde / Q000031:analogs & derivatives / Q000096:biosynthesis; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D016588:Anticarcinogenic Agents; C502487:Rbp4 protein, mouse; D054839:Retinol-Binding Proteins, Plasma; C525876:retinal dimer; D017313:Fenretinide; D006899:Mixed Function Oxygenases; C079232:beta-carotene hydroxylase; D012172:Retinaldehyde