title: [Association between baseline high sensitivity C-reactive protein level and the first cardio-cerebral vascular event in diabetic population: a prospective cohort study].
abstract: OBJECTIVE
  To evaluate the predictive value of baseline serum high sensitivity C-reactive protein for the first cardio-cerebral vascular event in the population with diabetes.
  
  
  METHODS
  In this prospective cohort study, a total of 101 510 employees of Kai Luan Group, who received healthy examination from July 2006 to October 2007, were screened and 7865 subjects with fasting plasma glucose ≥ 7.0 mmol/L or known diabetes mellitus and under insulin or hypoglycemic drugs therapy were followed up for 38 - 53 (48.02 ± 3.14) months.
  
  
  RESULTS
  (1) Incidence rates of total cardio-cerebral vascular events, cerebral infarction and myocardial infarction increased in proportion to increased levels of baseline hsCRP (P < 0.01). After adjusting for age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and cigarette smoking, multivariate Cox's proportional hazards regression analysis indicated that the individuals in the highest quartile of hsCRP levels group (hsCRP ≥ 2.50 mg/L) had an increased risk of total cardio-cerebral vascular events (RR: 1.64, 95% CI: 1.20 - 2.24), cerebral infarction (RR: 1.52, 95% CI: 1.03 - 2.24), myocardial infarction (RR: 2.57, 95% CI: 1.34 - 4.91) compared with those in the lowest quartile group (hsCRP < 0.41 mg/L). (2) Higher baseline hsCRP levels were associated with aging, female gender, higher BMI, SBP, DBP, fasting blood glucose, TC, TG, LDL-C levels and lower HDL-C levels (all P < 0.05).
  
  
  CONCLUSIONS
  Baseline hsCRP level is associated with increased first cardio-cerebral vascular event in the population with diabetes.
authors.affiliation: Department of Cardiology, Affiliated Kailuan Hospital, Hebei United University, Tangshan 063000, China.
authors.forename: Li-ye
authors.initials: LY
authors.lastname: Wang
authors.forename: Shou-ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Yang
authors.forename: Ting-jun
authors.initials: TJ
authors.lastname: Wang
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Su
authors.forename: Jing-sheng
authors.initials: JS
authors.lastname: Gao
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zheng
authors.forename: Xiu-rong
authors.initials: XR
authors.lastname: Liu
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein