title: Synthesis and antioxidant and antitumor activity of novel pyridine, chromene, thiophene and thiazole derivatives.
abstract: 2-Tosylacetonitrile (1) when reacted with α,β-unsaturated nitriles 2a-c or a mixture of formaldehyde and 3-amino-2-substituted-pent-2-endinitriles 6a,b yielded pyridine derivatives 3a-c and 9a,b, respectively, while when subjected to react with salicylaldehyde yielded chromene derivatives 4 and 5, subsequently. The behavior of thiocarbamoyl derivative 10 derived from 1 towards some α-halogenated compounds have been investigated as well as its behavior towards elemental sulfur and phenyl isothiocyanate. Newly synthesized compounds were screened for their antioxidant activity, erythrocytes haemolysis and bleomycin-independent DNA damage. Some of the tested compounds exhibited promising activities.
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt. afadda2@yahoo.com
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Fadda
authors.forename: Moged A
authors.initials: MA
authors.lastname: Berghot
authors.forename: Fathy A
authors.initials: FA
authors.lastname: Amer
authors.forename: Doria S
authors.initials: DS
authors.lastname: Badawy
authors.forename: Nesma M
authors.initials: NM
authors.lastname: Bayoumy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D004249:DNA Damage; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001578:Benzopyrans; D011725:Pyridines; D013844:Thiazoles; D013876:Thiophenes