title: Clinical application of a hyperdry amniotic membrane on surgical defects of the oral mucosa.
abstract: OBJECTIVE
  The aim of this study was to evaluate the usefulness of a hyperdry amniotic membrane (AM), a novel preservable human amnion, as a wound-dressing material for surgical defects of the oral mucosa.
  
  
  METHODS
  A hyperdry AM was used in the treatment of 10 patients who had developed secondary defects in the tongue and buccal mucosa after the surgical removal of cancerous or precancerous lesions. The effectiveness of the hyperdry AM was assessed by scoring its operability during the surgical procedure and by the hemostatic status, pain relief, feeding situation, epithelialization, and scar contracture in the postoperative period. Its usefulness was evaluated by considering its effectiveness and safety based on the absence of wound infection and graft rejection.
  
  
  RESULTS
  The membrane was found to be easy to handle as an oral-dressing material. It adhered well to the bare connective and muscular tissues. One lingual case showed slight postoperative bleeding, which astriction then stopped. No remarkable adverse effects were observed in the process of wound healing. The average score of the patients was 11.2 points (10 to 13 points) in the present evaluation, with 14 being the highest possible score.
  
  
  CONCLUSIONS
  This study showed the clinical usefulness of the hyperdry AM as an intraoral wound-dressing material. Although the number of cases was small, the results suggested that the hyperdry AM is biologically acceptable to oral wounds and could be a suitable clinical alternative for the repair of the oral mucosa.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan. arai@med.u-toyama.ac.jp
authors.forename: Naoya
authors.initials: N
authors.lastname: Arai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsuno
authors.forename: Motonori
authors.initials: M
authors.lastname: Okabe
authors.forename: Toshiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chika
authors.initials: C
authors.lastname: Koike
authors.forename: Makoto
authors.initials: M
authors.lastname: Noguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nikaido
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000650:Amnion; D001684:Biological Dressings; D002921:Cicatrix / Q000473:pathology; D003286:Contracture / Q000473:pathology; D004435:Eating / Q000502:physiology; D004848:Epithelium / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery*; D009062:Mouth Neoplasms / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D011230:Precancerous Conditions / Q000601:surgery; D012449:Safety; D014059:Tongue / Q000601:surgery*; D014062:Tongue Neoplasms / Q000601:surgery; D014945:Wound Healing / Q000502:physiology