title: The causal exposure model of vascular disease.
abstract: Primary prevention of cardiovascular disease is governed at present by the risk factor model for cardiovascular events, a model which is widely accepted by physicians and professional associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also allows atherosclerosis to develop and progress unchecked within the arterial tree with the result that the absolute effectiveness of preventive therapy is limited by the time it is eventually initiated. The causal exposure model of vascular disease is an alternative to the risk factor model for cardiovascular events. Whereas the risk factor model aims to identify and treat those at markedly increased risk of vascular events within the next decade, the causal exposure model of vascular disease aims to prevent events by treating the causes of the disease when they are identified. In the risk factor model, age is an independent non-modifiable risk factor and the predictive power of age far outweighs that of the other risk factors. In the causal exposure model, age is the duration of time the arterial wall is exposed to the causes of atherosclerosis: apoB (apolipoprotein B) lipoproteins, hypertension, diabetes and smoking. Preventing the development of advanced atherosclerotic lesions by treating the causes of vascular disease is the simplest, surest and most effective way to prevent clinical events.
authors.affiliation: Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, QC, Canada. allansniderman@hotmail.com
authors.forename: Allan D
authors.initials: AD
authors.lastname: Sniderman
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Lawler
authors.forename: Ken
authors.initials: K
authors.lastname: Williams
authors.forename: George
authors.initials: G
authors.lastname: Thanassoulis
authors.forename: Jacqueline
authors.initials: J
authors.lastname: de Graaf
authors.forename: Curt D
authors.initials: CD
authors.lastname: Furberg
mesh_terms: D000367:Age Factors; D006801:Humans; D008955:Models, Cardiovascular; D012307:Risk Factors; D014652:Vascular Diseases / Q000209:etiology* / Q000517:prevention & control