title: "Ring-fencing" BRCA1 tumor suppressor activity.
abstract: BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK. kjp@mrc-lmb.cam.ac.uk
authors.forename: Ketan J
authors.initials: KJ
authors.lastname: Patel
authors.forename: Gerry P
authors.initials: GP
authors.lastname: Crossan
authors.forename: Michael R G
authors.initials: MR
authors.lastname: Hodskinson