title: Endoscopic ultrasonography in gastric lymphomas: appraisal on reliability in long-term follow-up.
abstract: The reliability of endoscopic ultrasonography (EUS) in follow-up management of gastric lymphomas has not been clearly validated. We conducted a retrospective analysis on 23 patients, 12 affected by mucosa-associated lymphoid tissue (MALT) lymphoma, eight by diffuse large B-cell lymphoma, and three by high-grade lymphoma with low-grade component, all treated with a stomach-conservative approach. One hundred and twenty matched evaluations with both EUS and endoscopy with biopsy (E-Bx) were performed, according to validated guidelines and clinical judgment. At a median follow-up of 87 months ranged between 9.5 and 166 months, the analysis of progression-free survival and disease-free survival showed a strict relationship between the persistence of EUS abnormalities and the clinical outcome in patients with MALT lymphoma (p = 0.0079; p = 0.02) but not in patients with high-grade lymphoma. In conclusion, EUS evaluation does not seem reliable in follow-up management of high-grade lymphomas, although it could have a great clinical impact in the management of MALT lymphoma.
authors.affiliation: Division of Hematology, University of Catania, Ospedale Ferrarotto, A.O. Policlinico-Vittorio Emanuele, Catania, Italy. gerovetro@gmail.com
authors.forename: Calogero
authors.initials: C
authors.lastname: Vetro
authors.forename: Alessandra
authors.initials: A
authors.lastname: Romano
authors.forename: Annalisa
authors.initials: A
authors.lastname: Chiarenza
authors.forename: Concetta
authors.initials: C
authors.lastname: Conticello
authors.forename: Daniela
authors.initials: D
authors.lastname: Donnarumma
authors.forename: Ausilia
authors.initials: A
authors.lastname: Gorgone
authors.forename: Francesco
authors.initials: F
authors.lastname: Coppolino
authors.forename: Giuseppe Alberto
authors.initials: GA
authors.lastname: Palumbo
authors.forename: Giacomo
authors.initials: G
authors.lastname: Bonanno
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Raimondo
mesh_terms: D000328:Adult; D000368:Aged; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D015996:Survival Rate; D055815:Young Adult