title: Effect of Bixa orellana against Leishmania amazonensis.
abstract: BACKGROUND
  In the present study, an activity of Bixa orellana extract against Leishmania amazonensis was demonstrated.
  
  
  RESULTS
  Experimentally infected BALB/c mice were treated with B. orellana extract which showed a significant activity against promastigote and amastigote forms of L. amazonensis.
  
  
  CONCLUSIONS
  This study supports the importance of natural sources as antileishmanial drugs.
authors.affiliation: Departmento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de La Habana, Cuba.
authors.forename: Marley
authors.initials: M
authors.lastname: García
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
authors.forename: Ana M
authors.initials: AM
authors.lastname: Montalvo
authors.forename: Ramón
authors.initials: R
authors.lastname: Scull
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D031212:Bixaceae / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D008018:Life Cycle Stages / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D000666:Amphotericin B