title: Genetic association between the dopamine D3 receptor gene polymorphism (Ser9Gly) and tardive dyskinesia in patients with schizophrenia: a reevaluation in East Asian populations.
abstract: The dopamine D3 receptor gene (DRD3) is considered being one of the candidate genes contributing to the development of tardive dyskinesia (TD). In a recent meta-analysis with mixed ethnicities, only a barely positive association was found between the functional DRD3 Ser9Gly polymorphism and TD in patients with schizophrenia (OR=1.17; 95% CI: 1.01-1.37; p=0.041). To further evaluate the controversial association between the polymorphism and TD using only Japanese subjects, we tested the association in a case-control design. We also conducted a meta-analysis including 8 studies with 3 East Asian populations (Japanese, Chinese, and Korean). In our Japanese case-control sample (43 with TD/157 without TD), we found no association between the DRD3 Ser9Gly polymorphism in schizophrenia and TD (genotype: p=0.92; allele: p=1.00). Furthermore, no significant difference in the mean AIMS score among the three genotypic groups was observed in our sample. The meta-analysis comprising 1291 East Asian subjects also showed no association between the polymorphism and TD; the Mantel-Haenszel pooled OR for TD among carriers of the DRD3 Ser9Gly of the eight Asian studies was 0.94 (95% CI: 0.78-1.12). Overall, our results suggest that the DRD3 Ser9Gly polymorphism may not confer susceptibility to TD in East Asian populations. Given that the Ser9Gly variant may play a putative role in the DRD3 function, further studies on the DRD3 are warranted.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan. k-utsu@med.uoeh-u.ac.jp
authors.forename: Kensuke
authors.initials: K
authors.lastname: Utsunomiya
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shinkai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakata
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamada
authors.forename: Hsin-I
authors.initials: HI
authors.lastname: Chen
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
authors.forename: Rudi
authors.initials: R
authors.lastname: Hwang
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohmori
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D044466:Asian People / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D056726:Genetic Association Studies; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D050637:Receptors, Dopamine D3