title: Organometallic cages as vehicles for intracellular release of photosensitizers.
abstract: Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic therapy.
authors.affiliation: Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH-1011 Lausanne, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Schmitt
authors.forename: Julien
authors.initials: J
authors.lastname: Freudenreich
authors.forename: Nicolas P E
authors.initials: NP
authors.lastname: Barry
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat-Jeanneret
authors.forename: Georg
authors.initials: G
authors.lastname: Süss-Fink
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
mesh_terms: D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008967:Molecular Biology; D009942:Organometallic Compounds / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011166:Porphyrins; C107018:porphine