title: Additional drug resistance in Mycobacterium tuberculosis isolates from resected cavities among patients with multidrug-resistant or extensively drug-resistant pulmonary tuberculosis.
abstract: The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA. rkempke@emory.edu
authors.forename: Russell R
authors.initials: RR
authors.lastname: Kempker
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Rabin
authors.forename: Ketino
authors.initials: K
authors.lastname: Nikolaishvili
authors.forename: Iagor
authors.initials: I
authors.lastname: Kalandadze
authors.forename: Shota
authors.initials: S
authors.lastname: Gogishvili
authors.forename: Henry M
authors.initials: HM
authors.lastname: Blumberg
authors.forename: Sergo
authors.initials: S
authors.lastname: Vashakidze
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008168:Lung / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents