title: Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms.
abstract: Biomechanical factors play fundamental roles in the natural history of abdominal aortic aneurysms (AAAs) and their responses to treatment. Advances during the past two decades have increased our understanding of the mechanics and biology of the human abdominal aorta and AAAs, yet there remains a pressing need for considerable new data and resulting patient-specific computational models that can better describe the current status of a lesion and better predict the evolution of lesion geometry, composition, and material properties and thereby improve interventional planning. In this paper, we briefly review data on the structure and function of the human abdominal aorta and aneurysmal wall, past models of the mechanics, and recent growth and remodeling models. We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs.
authors.affiliation: Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Malone Engineering Center, Yale University, New Haven, CT 06520-8260, USA. jay.humphrey@yale.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Humphrey
authors.forename: G A
authors.initials: GA
authors.lastname: Holzapfel
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D001696:Biomechanical Phenomena / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular