title: Increased contact heat pain and shortened latencies of contact heat evoked potentials following capsaicin-induced heat hyperalgesia.
abstract: OBJECTIVE
  To examine changes in contact heat evoked potentials (CHEPs) and perceived pain intensity following acute sensitization with topical capsaicin.
  
  
  METHODS
  CHEPs were recorded before and after 20 min of topical capsaicin application (200 μl, 5%) during skin warming in 22 healthy subjects. To evaluate the sequence effects and skin warming on CHEPs, 10 of these subjects also participated in a control study.
  
  
  RESULTS
  Topical capsaicin yielded an increase in contact heat evoked pain ratings (p < 0.0001) and a shortening in N2 latency from a mean 345.2 ± 37.2 ms to 310.2 ± 38.5 ms recorded from the vertex position (p = 0.003, paired t-test). No difference was found in the N2-P2 peak-to-peak amplitude (p = 0.83). These results were unchanged after controlling for sequence effects and skin warming. Following capsaicin, ultralate CHEPs (N2a latencies 970-1352 ms) were recorded in three subjects.
  
  
  CONCLUSIONS
  Our study showed a decrease in late CHEPs latencies and appearance of ultralate potentials compatible with sensitization of Aδ fibers and C fibers.
  
  
  CONCLUSIONS
  Contact heat may be a useful tool to assess sensitization of the pain system.
authors.affiliation: Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark. caspar.madsen@ki.au.dk
authors.forename: C S
authors.initials: CS
authors.lastname: Madsen
authors.forename: B
authors.initials: B
authors.lastname: Johnsen
authors.forename: A
authors.initials: A
authors.lastname: Fuglsang-Frederiksen
authors.forename: T S
authors.initials: TS
authors.lastname: Jensen
authors.forename: N B
authors.initials: NB
authors.lastname: Finnerup
mesh_terms: D000328:Adult; D002211:Capsaicin / Q000009:adverse effects* / Q000494:pharmacology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D018689:Sensory System Agents / Q000009:adverse effects / Q000494:pharmacology; D012867:Skin / Q000294:innervation; D012881:Skin Temperature / Q000502:physiology
chemical_list: D018689:Sensory System Agents; D002211:Capsaicin