title: [Successful anesthetic management for resection of a giant hepatic hemangioma with Kasabach-Merritt syndrome using FloTrac system].
abstract: Kasabach-Merritt syndrome (KMS) is a rare and severe coagulation disorder caused by vascular malformations within or outside the liver. It is characterized by profound thrombocytopenia, microangiopathic hemolytic anemia, and consumption coagulopathy. We successfully managed the anesthesia for a giant hemangioma resection complicated with KMS using FloTrac/Vigileo system. A 78-year-old woman (51 kg, 141 cm) was admitted for giant hemangioma with disseminated intravascular coagulation (DIC). General anesthesia was induced with sevoflurane and remifentanil. Epidural anesthesia was not induced because of coagulopathy. We evaluated arterial pressure-based cardiac output (APCO), stroke volume variation (SVV) as a predictor for fluid responsiveness, systolic blood pressure (SBP), and central venous pressure (CVP) during the operation. Prior to tumor resection, 6,000 ml of fluid was suctioned from the tumor. The increase of SVV and sudden decrease of APCO and SBP were recognized during surgical procedure. The SVV demonstrated marked changes in response to hemorrhage, and it was more sensitive than CVP change during operation. We conclude that SVV is an accurate predictor of intravascular hypovolemia, and it is a useful indicator for assessing the appropriateness and timing of applying fluid for improving circulatory stability during a giant hemoangioma resection.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo 113-8421.
authors.forename: Saiko
authors.initials: S
authors.lastname: Wakabayashi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Toyoki
authors.initials: T
authors.lastname: Kugimiya
authors.forename: Eiichi
authors.initials: E
authors.lastname: Inada
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D002496:Central Venous Pressure; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D006391:Hemangioma / Q000150:complications* / Q000601:surgery*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D007430:Intraoperative Care; D059885:Kasabach-Merritt Syndrome / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000601:surgery*; D016343:Monitoring, Intraoperative / Q000295:instrumentation*; D009638:Norepinephrine / Q000008:administration & dosage; D013318:Stroke Volume
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D009638:Norepinephrine