title: Experimental study of δ-ALA-PDT in the treatment in BXSB lupus-prone mice.
abstract: Extracorporeal photochemotherapy can correct immune disease and treat many autoimmune diseases. The aim of this study was to investigate the effects of delta-aminolevulinic acid photodynamic therapy (δ-ALA-PDT) on BXSB mouse. The 24-h urine protein, titers of serum antinuclear antibodies, peripheral blood lymphocyte apoptosis and deposition of immune complex in renal glomeruli were determined in BXSB mice after δ-ALA-PDT treatment. Results showed that δ-ALA-PDT treatment could reduce 24-h urine protein, titers of serum antinuclear antibodies, and deposition of immune complex in renal glomeruli. The δ-ALA-PDT treatment could also lead to significant increase in the rate of peripheral blood lymphocytes.
authors.affiliation: Department of Dermatology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shangdong Province, PR China. zsslhx@126.com
authors.forename: Zhou
authors.initials: Z
authors.lastname: Surong
authors.forename: Liu
authors.initials: L
authors.lastname: Chuanyu
authors.forename: Xv
authors.initials: X
authors.lastname: Shizheng
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D018450:Disease Progression; D007105:Immune Complex Diseases / Q000628:therapy; D007678:Kidney Glomerulus; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D017893:Photopheresis; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000974:Antibodies, Antinuclear; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid