title: Skeletal effects of the saturated 3-thia Fatty Acid tetradecylthioacetic Acid in rats.
abstract: This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, NTNU, Olav Kyrres gate 9, 7489 Trondheim, Norway.
authors.forename: Astrid Kamilla
authors.initials: AK
authors.lastname: Stunes
authors.forename: Irene
authors.initials: I
authors.lastname: Westbroek
authors.forename: Reidar
authors.initials: R
authors.lastname: Fossmark
authors.forename: Rolf Kristian
authors.initials: RK
authors.lastname: Berge
authors.forename: Janne Elin
authors.initials: JE
authors.lastname: Reseland
authors.forename: Unni
authors.initials: U
authors.lastname: Syversen