title: Necroptosis turns TNF lethal.
abstract: In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo.
authors.affiliation: INSERM, U848, Villejuif, F-94805, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer