title: miR-210: the master hypoxamir.
abstract: MicroRNAs are small non-coding RNAs implicated mainly in post-transcriptional gene silencing by interacting with the untranslated region of the transcript. miR-210 represents major hypoxia-inducible miRs, also known as hypoxamirs, which is ubiquitously expressed in a wide range of cells, serving versatile functions. This review article summarizes the current progress on biogenesis of miR-210 and its physiological roles including arrest of cell proliferation, repression of mitochondrial respiration, arrest of DNA repair, vascular biology, and angiogenesis. Given the fact that miR-210 is aberrantly expressed in a number of diseases such as tumor progression, myocardial infarction and cutaneous ischemic wounds, miR-210 could serve as an excellent candidate for prognostic purposes and therapeutic intervention. With the advancement of computational prediction, high-throughput target validation methodology, sequencing, proteomic analysis, and microarray, it is anticipated that more down-stream targets of miR-210 and its associated biological consequences under hypoxia will be unveiled establishing miR-210 as a major hub in the biology of hypoxia-response.
authors.affiliation: Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
authors.forename: Yuk C
authors.initials: YC
authors.lastname: Chan
authors.forename: Jaideep
authors.initials: J
authors.lastname: Banerjee
authors.forename: Sang Yong
authors.initials: SY
authors.lastname: Choi
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Sen
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D004260:DNA Repair; D015870:Gene Expression; D006801:Humans; D000860:Hypoxia / Q000235:genetics* / Q000503:physiopathology*; D007511:Ischemia / Q000628:therapy; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D018919:Neovascularization, Physiologic; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs