title: Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol.
abstract: The present study investigated the hormones concentrations and gonads alterations of Clarias gariepinus caused by sublethel concentrations of 4-nonylphenol (0, 0.05, 0.08 and 0.1 mg/l). The changes in the activities of the hormones after exposure to these sublethel doses of 4-nonylpenol referred to endocrine disruption in Clarias gariepinus in association with histopathological changes in reproductive tissues. The levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), total thyroxine (T4), follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone concentrations significantly decreased (P<0.05) in the treated fish in comparison with control. 17-β-estradiol increased significantly (P<0.05) with 4-nonylphenol concentrations increase. Reduction in the gonadosomatic index was evident with increase of sublethal doses of 4-nonylphenol. The histopathological changes of NP-treated were recorded in gonads of Clarias gariepinus reflecting their sensitivity to NP-estrogenic like effects.
authors.affiliation: Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt. alaa_h254@yahoo.com
authors.forename: Alaa El-Din H
authors.initials: Ael-D
authors.lastname: Sayed
authors.forename: Usama M
authors.initials: UM
authors.lastname: Mahmoud
authors.forename: Imam A
authors.initials: IA
authors.lastname: Mekkawy
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002397:Catfishes / Q000378:metabolism*; D052244:Endocrine Disruptors / Q000633:toxicity*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010636:Phenols / Q000633:toxicity*; D013739:Testosterone / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D015415:Biomarkers; D052244:Endocrine Disruptors; D010636:Phenols; D014284:Triiodothyronine; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; C041594:4-nonylphenol; D013974:Thyroxine