title: Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels.
abstract: Transportation fuels will gradually shift from oil based fuels towards alternative fuel resources like biofuels. Current bioethanol and biodiesel can, however, not cover the increasing demand for biofuels and there is therefore a need for advanced biofuels with superior fuel properties. Novel cell factories will provide a production platform for advanced biofuels. However, deep cellular understanding is required for improvement of current biofuel cell factories. Fast screening and analysis (-omics) methods and metabolome-wide mathematical models are promising techniques. An integrated systems approach of these techniques drives diversity and quantity of several new biofuel compounds. This review will cover the recent technological developments that support improvement of the advanced biofuels 1-butanol, biodiesels and jetfuels.
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.
authors.forename: Bouke
authors.initials: B
authors.lastname: de Jong
authors.forename: Verena
authors.initials: V
authors.lastname: Siewers
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
mesh_terms: D056804:Biofuels; D007218:Industrial Microbiology / Q000379:methods*; D055442:Metabolome; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D049490:Systems Biology / Q000379:methods*; D015003:Yeasts / Q000378:metabolism
chemical_list: D056804:Biofuels