title: Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet.
abstract: Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder, and it will continue to be a major liver health issue worldwide in the coming decades. We aimed to determine the effect of Liv-Pro-08 (Nigella sativa, Entada pursaetha, and Ficus glomerata) an oral ayurvedic formulation on rats fed with high-fat diet. Rats were given a high-fat diet for a period of 7 days. After this period, Liv-Pro-08 (250, 500, and 750 mg/kg.body weight was given orally for 7 days. We examined the effect of the high-fat diet on various parameters related to obesity and insulin resistance. In the experimental rats who received the extract of Liv-Pro-08, their lipoprotein profiles were significantly improved compared with those that are not receiving the extract. Also, a slight reduction was observed in serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzymes. Moreover, Liv-Pro-08 significantly decreased their fasting serum glucose and fasting insulin levels. This experimental study suggests that Liv-Pro-08 can act as a therapeutic tool in preventing NAFLD progression (i.e., reducing hepatic lipid accumulation). Although further investigations and large randomized trials should be conducted, ayurvedic Liv-Pro-08 oral formulation may be a potential natural drug for NAFLD in the future.
authors.affiliation: Department of Biochemistry, Periyar University, Tamilnadu, India. suriyaveda@yahoo.co.in
authors.forename: M
authors.initials: M
authors.lastname: Suriyavathana Vedanarayanan
authors.forename: Nandhini
authors.initials: N
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000378:metabolism; D007887:Fabaceae / Q000737:chemistry; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D030681:Ficus / Q000737:chemistry; D007328:Insulin / Q000097:blood; D031881:Nigella sativa / Q000737:chemistry; D065626:Non-alcoholic Fatty Liver Disease; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D010936:Plant Extracts