title: Lacosamide use in refractory idiopathic primary generalized epilepsy.
abstract: Treatment of refractory idiopathic primary generalized epilepsy can be very challenging, with limited drug options, especially in young women of childbearing age. Here we describe the cases of two young women with refractory idiopathic primary generalized epilepsy refractory to multiple antiepileptic drugs in monotherapy or combination before achieving a long-term remission with adjunctive lacosamide (LCS) treatment. Larger, randomized prospective studies are necessary to establish the effectiveness of lacosamide in these patients.
authors.affiliation: Virtua Neuroscience, Virtua Health System, Virtua Medical Group, Voorhees, NJ 08043, USA. azangaladze@virtua.org
authors.forename: Andro
authors.initials: A
authors.lastname: Zangaladze
authors.forename: Christopher
authors.initials: C
authors.lastname: Skidmore
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000078334:Lacosamide; D055815:Young Adult
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide