title: PET tracers based on Zirconium-89.
abstract: Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), (89)Zr has been extensively studied over the last decade. This review article will give a brief overview on (89)Zr isotope production, the radiochemistry generally used for (89)Zr-labeling, and the PET tracers that have been developed using (89)Zr. To date, (89)Zr-based PET imaging has been investigated for a wide variety of cancer-related targets, which include human epidermal growth factor receptor 2, epidermal growth factor receptor, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, carbonic anhydrase IX, insulin-like growth factor 1 receptor, among others. With well-developed radiochemistry, commercial availability of chelating agents for (89)Zr labeling, increasingly widely available isotope supply, as well as successful proof-of-principle in pilot human studies, it is expected that PET imaging with (89)Zr-based tracers will be a constantly evolving and highly vibrant field in the near future.
authors.affiliation: Departments of Radiology and Medical Physics, School of Medicine and Public Health, University ofWisconsin - Madison, Madison, WI 53705-2275, USA.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D066246:ErbB Receptors / Q000032:analysis; D043425:Glutamate Carboxypeptidase II / Q000032:analysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007553:Isotope Labeling; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis; D015040:Zirconium
chemical_list: D000954:Antigens, Surface; D066246:ErbB Receptors; D043425:Glutamate Carboxypeptidase II; D018960:Hyaluronan Receptors; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D018719:Erb-b2 Receptor Tyrosine Kinases; D042461:Vascular Endothelial Growth Factor A; D015040:Zirconium; C112697:CD44v6 antigen; C508053:ERBB2 protein, human; C473848:FOLH1 protein, human