title: High expression of tumor-infiltrating macrophages correlates with poor prognosis in patients with diffuse large B-cell lymphoma.
abstract: Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. Although the International Prognostic Index (IPI) provides a clinical model for risk stratification of patients with DLBCL, notable variability in outcome is still observed within the same IPI category. Tumor-infiltrating macrophages (also called Tumor-associated macrophages) are the major component in the microenvironment of DLBCL. Their correlation with the prognosis of DLBCL remains controversial. Using a CD68 antibody in immunohistochemical analysis, we studied the expression of CD68 in 112 Chinese patients with DLBCL, with 65 patients (58%) categorized as low CD68 expression and 47 patients (42%) as high CD68 expression. The complete response (CR) rate of patients with low CD68 expression was higher than that with high CD68 expression (66.1% vs. 51.6%), but there was no statistical significance (P=0.060). The median survival time of patients with low CD68 expression was not achieved and that of high expression was 41 months (P=0.029). The results suggest that higher expression of CD68 tended to yield poor treatment outcome of DLBCL.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Medical Oncology, Lymphoma Centre, Cancer Center of Sun Yat-sen University, 651 Dong Feng Road East, Guangzhou, 510060, Guangdong, People's Republic of China.
authors.forename: Qi-chun
authors.initials: QC
authors.lastname: Cai
authors.forename: Hong
authors.initials: H
authors.lastname: Liao
authors.forename: Su-xia
authors.initials: SX
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Xiao-xaio
authors.initials: XX
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Ze-xiao
authors.initials: ZX
authors.lastname: Lin
authors.forename: Jia-bin
authors.initials: JB
authors.lastname: Lu
authors.forename: Hui-qiang
authors.initials: HQ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000401:mortality*; D008264:Macrophages / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule