title: Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs.
abstract: Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL).
authors.affiliation: Department of Laboratory Medicine and Pathology, 1-71 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.
authors.forename: Naveen C
authors.initials: NC
authors.lastname: Srivastav
authors.forename: Neeraj
authors.initials: N
authors.lastname: Shakya
authors.forename: Sudha
authors.initials: S
authors.lastname: Bhavanam
authors.forename: Amogh
authors.initials: A
authors.lastname: Agrawal
authors.forename: Chris
authors.initials: C
authors.lastname: Tse
authors.forename: Nancy
authors.initials: N
authors.lastname: Desroches
authors.forename: Dennis Y
authors.initials: DY
authors.lastname: Kunimoto
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011741:Pyrimidine Nucleosides