title: One clinic visit for pre-exposure rabies vaccination (a preliminary one year study).
abstract: We performed an abbreviated prospective study of rabies pre-exposure (PREP) vaccination in 109 volunteers. Group 1, the control group, received the conventional 3 intradermal injections on days 0, 7 and 21. Group 2 received one rabies vaccine injection (0.1 ml intradermally) at 2 sites on a single day. Group 3 was given one full ampule intramuscularly. One year later, all 3 groups received booster injections (0.1 ml at 4 sites) intradermally at one time or 2 injections intramuscularly on days 0 and 3. All subjects achieved a vigorous anamnestic antibody response 7 days after the boosters. These data suggest that one time immunization of one full dose intramuscularly or 2 site injections of 0.1 intradermally on a single day are adequate to prime immune memory and obtain an accelerated immune response one year later.
authors.affiliation: Queen Saovabha Memorial Institute, the Thai Red Cross Society, Bangkok 10330, Thailand. pakamatz@yahoo.com
authors.forename: Pakamatz
authors.initials: P
authors.lastname: Khawplod
authors.forename: Wipaporn
authors.initials: W
authors.lastname: Jaijaroensup
authors.forename: Artikaya
authors.initials: A
authors.lastname: Sawangvaree
authors.forename: Sompop
authors.initials: S
authors.lastname: Prakongsri
authors.forename: Henry
authors.initials: H
authors.lastname: Wilde
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006805:Human Experimentation; D006801:Humans; D007156:Immunologic Memory; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014611:Vaccination / Q000379:methods*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines