title: New insights into redox-modulated cell signaling.
abstract: The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Leonarduzzi
authors.forename: Barbara
authors.initials: B
authors.lastname: Sottero
authors.forename: Gabriella
authors.initials: G
authors.lastname: Testa
authors.forename: Fiorella
authors.initials: F
authors.lastname: Biasi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Poli
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D010084:Oxidation-Reduction; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; D010749:Phosphoprotein Phosphatases