title: External validation of a laparoscopic-based score to evaluate resectability for patients with advanced ovarian cancer undergoing interval debulking surgery.
abstract: OBJECTIVE
  To evaluate the relevance of laparoscopic index of Fagotti et al during staging laparoscopy (S-LPS) to predict optimal cytoreduction during interval debulking surgery (IDS) after neoadjuvant chemotherapy for ovarian cancer.
  
  
  METHODS
  Fifty-two patients with stage III-IV ovarian cancer were retrospectively analyzed. We evaluated discrimination with a receiver operating characteristic (ROC) curve analysis and calibration of Fagotti et al's model among our population and compared this performance with their data.
  
  
  RESULTS
  A score >4 was associated with optimal resection with sensitivity and positive predictive value (PPV) of 95% and 82% respectively. The ROC curve analysis gave an area under the curve (AUC) of 0.72 (95% confidence interval (CI) 0.65-0.80) for our population compared to 0.88 (95% CI 0.84-0.91) in Fagotti et al's population. Percentages predicted in our population were unsatisfactory (p<0.01), illustrating the different rates of optimal cytoreduction between the centers (average error of 25%).
  
  
  CONCLUSIONS
  The laparoscopic index of Fagotti et al is relevant in prediction of optimal cytoreduction among women undergoing IDS.
authors.affiliation: Service de Gynécologie-Obstétrique, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France. elisabeth.chereau@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Chereau
authors.forename: V
authors.initials: V
authors.lastname: Lavoue
authors.forename: M
authors.initials: M
authors.lastname: Ballester
authors.forename: C
authors.initials: C
authors.lastname: Coutant
authors.forename: F
authors.initials: F
authors.lastname: Selle
authors.forename: A
authors.initials: A
authors.lastname: Cortez
authors.forename: E
authors.initials: E
authors.lastname: Daraï
authors.forename: J
authors.initials: J
authors.lastname: Leveque
authors.forename: R
authors.initials: R
authors.lastname: Rouzier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002138:Calibration; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D012372:ROC Curve; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome