title: Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum.
abstract: The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC, Australia.
authors.forename: Wai-Hong
authors.initials: WH
authors.lastname: Tham
authors.forename: Julie
authors.initials: J
authors.lastname: Healer
authors.forename: Alan F
authors.initials: AF
authors.lastname: Cowman
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D008018:Life Cycle Stages / Q000276:immunology; D017780:Malaria Vaccines / Q000276:immunology* / Q000378:metabolism; D016778:Malaria, Falciparum / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity; D015800:Protozoan Proteins / Q000276:immunology* / Q000378:metabolism; D012156:Reticulocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D017780:Malaria Vaccines; D015800:Protozoan Proteins