title: Lack of association between prior depressive episodes and cerebral [11C]PiB binding.
abstract: Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-β (Aβ) levels using [(11)C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [(11)C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [(11)C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [(11)C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.
authors.affiliation: Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. karine@nru.dk
authors.forename: Karine
authors.initials: K
authors.lastname: Madsen
authors.forename: Bo J
authors.initials: BJ
authors.lastname: Hasselbalch
authors.forename: Kristian S
authors.initials: KS
authors.lastname: Frederiksen
authors.forename: Mette E
authors.initials: ME
authors.lastname: Haahr
authors.forename: Anders
authors.initials: A
authors.lastname: Gade
authors.forename: Ian
authors.initials: I
authors.lastname: Law
authors.forename: Julie C
authors.initials: JC
authors.lastname: Price
authors.forename: Gitte M
authors.initials: GM
authors.lastname: Knudsen
authors.forename: Lars V
authors.initials: LV
authors.lastname: Kessing
authors.forename: Steen G
authors.initials: SG
authors.lastname: Hasselbalch
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D016229:Amyloid beta-Peptides / Q000032:analysis; D000814:Aniline Compounds; D000928:Antidepressive Agents / Q000627:therapeutic use; D054022:Cerebrum / Q000000981:diagnostic imaging*; D003863:Depression / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012307:Risk Factors; D012720:Severity of Illness Index; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D000928:Antidepressive Agents; D019275:Radiopharmaceuticals; D013844:Thiazoles