title: Epigenetic regulation of osteoclast differentiation.
abstract: Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Osteoclasts are primary cells for bone resorption, and their differentiation is tightly regulated by the receptor activator of nuclear factor κB ligand (RANKL) and a transcription factor nuclear factor-activated T cell (NFAT) c1. We found that RANKL-induced NFATc1 expression is associated with the demethylation of H3K27me3. Jumonji domain containing-3, a H3K27 demethylase, is induced in bone marrow-derived macrophages in response to RANKL stimulation and may play a critical role in the demethylation of H3K27me3 in the Nfatc1 gene.
authors.affiliation: Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yasui
authors.forename: Jun
authors.initials: J
authors.lastname: Hirose
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aburatani
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism*; D001862:Bone Resorption / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism; D008745:Methylation; D050778:NFATC Transcription Factors / Q000096:biosynthesis; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism*; D053245:RANK Ligand / Q000378:metabolism
chemical_list: D006657:Histones; D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D056484:Jumonji Domain-Containing Histone Demethylases