title: Sedentary behavior and adiposity-associated inflammation: the Multi-Ethnic Study of Atherosclerosis.
abstract: BACKGROUND
  Sedentary behavior is associated with adiposity and cardiometabolic risk.
  
  
  OBJECTIVE
  To determine the associations between sedentary behavior and measures of adiposity-associated inflammation.
  
  
  METHODS
  Between 2002 and 2005, a total of 1543 Multi-Ethnic Study of Atherosclerosis participants completed detailed health history questionnaires, underwent physical measurements, and had blood assayed for adiponectin, leptin, tumor necrosis factor-alpha (TNF-α) and resistin. Analyses included linear regression completed in 2010. The mean age was 64.3 years and nearly 50% were female. Forty-one percent were non-Hispanic white, 24% Hispanic-American, 20% African-American, and 14% Chinese-American.
  
  
  RESULTS
  In linear regression analyses and with adjustment for age, gender, ethnicity, education, BMI, smoking, alcohol consumption, hypertension, diabetes mellitus, dyslipidemia, hormone therapy and waist circumference, sedentary behavior was associated with higher natural log ("ln") of leptin and ln TNF-α but a lower ln adiponectin-to-leptin ratio (β=0.07, β=0.03 and -0.07, p<0.05 for all). Compared to the first tertile, and after the same adjustment, the second and third tertiles of sedentary behavior were associated with higher levels of ln leptin (β=0.11 and β=0.12, respectively; p<0.05 for both) but lower levels of the adiponectin-to-leptin ratio (β=-0.09 and -0.11, respectively; p<0.05 for both).
  
  
  CONCLUSIONS
  Sedentary behavior is associated with unfavorable levels of adiposity-associated inflammation.
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California 92093-0965, USA. mallison@ucsd.edu
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Allison
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Jensky
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Marshall
authors.forename: Alain G
authors.initials: AG
authors.lastname: Bertoni
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D050154:Adiposity; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000208:ethnology / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D007249:Inflammation / Q000208:ethnology / Q000209:etiology*; D020738:Leptin / Q000378:metabolism; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology; D008875:Middle Aged; D057185:Sedentary Behavior; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D052242:Adiponectin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha