title: Variations on cardiovascular risk factors in metabolic syndrome after consume of a citrus-based juice.
abstract: OBJECTIVE
  Inflammation and oxidative stress plays a critical role in cardiovascular disease and metabolic syndrome often occurs with these two variables. The aim of the study is to estimate variations on cardiovascular risk factors in Metabolic Syndrome patients after consume of a citrus-based juice compared with control groups.
  
  
  METHODS
  The study comprised 20 healthy subjects and 33 patients with Metabolic Syndrome. 18 patients consume daily 300 mL of a citrus-based juice during 6 month and 15 patients consume 300 mL of a placebo beverage. The control group consumes a citrus-based juice. Before, at fourth month and at sixth month after treatment the following parameters were determined: lipid profile, oxidized LDL, C-Reactive Protein and Homocysteine. The study was carried out in accordance with the Helsinki Declaration, and the Ethical Committee of the San Antonio Catholic University and approved the protocol (6 November 2006, register number: 1424).
  
  
  RESULTS
  After six months of citrus-based juice consuming, there is significant differences at 95% confidence in oxidized LDL, C-Reactive Protein, and Homocysteine in Metabolic Syndrome patients who consume citrus-based juice. We have not found significant differences in other groups.
  
  
  CONCLUSIONS
  Consume of citrus-based juice improve lipid profile and inflammation markers in Metabolic Syndrome patients.
authors.affiliation: Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia 30107, Spain. jmulero@pdi.ucam.edu
authors.forename: Juana
authors.initials: J
authors.lastname: Mulero
authors.forename: Juana
authors.initials: J
authors.lastname: Bernabé
authors.forename: Begoña
authors.initials: B
authors.lastname: Cerdá
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Viguera
authors.forename: Diego A
authors.initials: DA
authors.lastname: Moreno
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Albaladejo
authors.forename: Francisco
authors.initials: F
authors.lastname: Avilés
authors.forename: Soledad
authors.initials: S
authors.lastname: Parra
authors.forename: José
authors.initials: J
authors.lastname: Abellán
authors.forename: Pilar
authors.initials: P
authors.lastname: Zafrilla
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis; D001628:Beverages / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002957:Citrus / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D008875:Middle Aged; D046936:Photinia / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D010936:Plant Extracts; C099252:oxidized low density lipoprotein; D006710:Homocysteine; D002097:C-Reactive Protein