title: N-acetylcysteine in children with dengue-associated liver failure: a case report.
abstract: There is no specific treatment for dengue-associated fulminant liver failure. We report a child with dengue-associated fulminant liver failure who was treated successfully with intravenous N-acetylcysteine. A 6-year-old boy was diagnosed with dengue-associated fulminant liver failure. After administration of intravenous N-acetylcysteine, a rapid decrease in liver transaminases and normalization of coagulation profile was observed followed by clinical improvement and favourable outcome despite factors associated with poor prognosis. The use of intravenous N-acetylcysteine is safe and efficient in the treatment of dengue-associated fulminant liver failure, especially in centres when liver transplantation is not readily available.
authors.affiliation: Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.
authors.forename: Grace
authors.initials: G
authors.lastname: Lim
authors.forename: Jan Hau
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage* / Q000627:therapeutic use; D061605:Administration, Intravenous; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D003715:Dengue / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017114:Liver Failure, Acute / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D011379:Prognosis; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000637:Transaminases; D000111:Acetylcysteine