title: Viperin: a multifunctional, interferon-inducible protein that regulates virus replication.
abstract: Viperin is an interferon-inducible protein that inhibits the replication of a variety of viruses by apparently diverse mechanisms. In some circumstances, it also plays a role in intracellular signaling pathways. Its expression in mitochondria, revealed by infection with human cytomegalovirus, also affects cellular metabolic pathways. We review here the current status of our understanding of this unusual molecule.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine New Haven, CT 06520-8011, USA.
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Seo
authors.forename: Rakina
authors.initials: R
authors.lastname: Yaneva
authors.forename: Peter
authors.initials: P
authors.lastname: Cresswell
mesh_terms: D000818:Animals; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism* / Q000821:virology*; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D000090123:Viperin Protein
chemical_list: D007372:Interferons; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins; C444427:RSAD2 protein, human; D000090123:Viperin Protein