title: Detection of organophosphorus compounds using a molecularly imprinted photonic crystal.
abstract: A label free molecularly imprinted photonic crystal (MIPC) was developed to detect the degradation product of nerve agents. Mono-dispersed poly-methyl methacrylate colloidal particles with the diameter of 280 nm were used to fabricate a closely packed colloidal crystal array (CCA), and a methyl phosphonic acid (MPA) imprinted hydrogel was prepared within the CCA using 2-hydroxyethyl-methacrylate and N-isopropylacrylamide as monomers, ethyleneglycol dimethacrylate and N, N'-methylenebisacrylamide as cross-linkers, a mixture of n-octanol and acetonitrile as porogen. The diffraction intensity of the MIPC decreased significantly upon the MPA adsorption with a limit of detection (LOD) of 10(-6) molL(-1). Furthermore, the diffraction intensity decreased and blue shifted with the increase of temperature, decreased and red shifted with the increase of ionic strength. At higher pH, the diffraction intensity increased without obvious diffraction shift. The MIPC provides an indirect path to detect nerve agents (Sarin, Soman, VX and R-VX) by monitoring the MPA released from the hydrolysis of nerve agents, with LODs of 3.5 × 10(-6) molL(-1), 2.5 × 10(-5) molL(-1), 7.5 × 10(-5) molL(-1) and 7.5 × 10(-5) molL(-1) for Sarin, Soman, VX and R-VX, respectively.
authors.affiliation: School of Chemical & Environmental Engineering, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Shuyue
authors.initials: S
authors.lastname: Huang
authors.forename: Fei
authors.initials: F
authors.lastname: Xue
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Zihui
authors.initials: Z
authors.lastname: Meng
authors.forename: Min
authors.initials: M
authors.lastname: Xue
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D002619:Chemical Warfare Agents / Q000032:analysis*; D003460:Crystallization; D057230:Limit of Detection; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods; D055095:Optics and Photonics / Q000379:methods*; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000737:chemistry
chemical_list: D000178:Acrylamides; D002619:Chemical Warfare Agents; D008689:Methacrylates; D009943:Organophosphorus Compounds; C032627:methylphosphonic acid; C005044:hydroxyethyl methacrylate; C067295:N-isopropylacrylamide