title: [Clinical and coronary angiographic features of patients with systemic vasculitis and coronary artery disease].
abstract: OBJECTIVE
  To evaluate the clinical and coronary angiographic features of patients with systemic vasculitis and coronary artery disease.
  
  
  METHODS
  Fifteen patients (11 male) with systemic vasculitis and coronary artery diseases admitted to our hospital from January 1999 to October 2009 were reviewed.
  
  
  RESULTS
  There were 6 patients with Behcet's disease, 3 patients with Churg-Strauss syndrome, 2 patients with Takayasu arteritis, 1 patient with polyarteritis nodosa, 1 patient with microscopic polyangiitis, 1 patient with Wegner's granulomatosis and 1 patient with Kawasaki disease. Mean age of this cohort was (39.3 ± 11.9) years. Adverse coronary events occurred in 4 patients during the inactive phase of systemic vasculitis and in 9 patients during the active phase of systemic vasculitis. Twelve patients were hospitalized with acute myocardial infarction, 2 with angina pectoris and 1 with cardiac tamponade. There were 3 patients with acute left ventricular dysfunction and 3 patients with severe arrhythmias. Compared to patients in the inactive phase, patients in the active phase were younger [(32.4 ± 8.1) years vs. (47.0 ± 10.2) years], had less risk factors for atherosclerosis (1.2 ± 1.5 to 2.8 ± 1.7) and the time intervals between coronary artery disease and systemic vasculitis was shorter [0 - 7 years (average 1.6 years) to 3 - 30 years (average 17.7 years)]. Coronary angiography evidenced coronary stenosis or occlusions in 11 patients, coronary aneurysm and acute thrombosis in 1 patient, coronary aneurysms and occlusions in 1 patient and coronary spasm in 2 patients. LVEF measured by echocardiography was less than 50% in 8 patients.
  
  
  CONCLUSIONS
  Patients with various systemic vasculitis could develop severe coronary artery disease due to coronary stenosis/occlusion, aneurysma, thrombosis and coronary spasm.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Zhu-jun
authors.initials: ZJ
authors.lastname: Shen
authors.forename: Chong-hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Shu-yang
authors.initials: SY
authors.lastname: Zhang
authors.forename: Zhong-jie
authors.initials: ZJ
authors.lastname: Fan
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Jin
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Liu
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Xie
authors.forename: Quan
authors.initials: Q
authors.lastname: Fang
mesh_terms: D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000150:complications / Q000473:pathology*