title: Critical role of autophage in ischemia/reperfusion injury to aged livers.
abstract: A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sensitivity of the liver to I/R injury with age. Our work suggests that a restoration or enhancement of autophagy is a novel therapeutic modality to ameliorate liver function after I/R to aged livers.
authors.affiliation: Department of Surgery, Division of Biology of Aging, University of Florida, Gainesville, FL, USA.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Wang
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Behrns
authors.forename: Christiaan
authors.initials: C
authors.lastname: Leeuwenburgh
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001343:Autophagy; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D015427:Reperfusion Injury / Q000473:pathology*
chemical_list: D008565:Membrane Proteins