title: High-affinity fluorescent ligands for the 5-HT(3) receptor.
abstract: The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Simonin
authors.forename: Sanjeev Kumar V
authors.initials: SK
authors.lastname: Vernekar
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: J Daniel
authors.initials: JD
authors.lastname: Hothersall
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Connolly
authors.forename: Sarah C R
authors.initials: SC
authors.lastname: Lummis
authors.forename: Martin
authors.initials: M
authors.lastname: Lochner
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry* / Q000378:metabolism; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D044406:Receptors, Serotonin, 5-HT3; D054852:Small Molecule Libraries