title: Antihepatotoxic activity of Phyllanthus atropurpureus cultivated in Egypt.
abstract: The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medicinal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl4-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt.
authors.forename: Taha
authors.initials: T
authors.lastname: Sarg
authors.forename: Afaf Abdel
authors.initials: AA
authors.lastname: Ghani
authors.forename: Rawia
authors.initials: R
authors.lastname: Zayed
authors.forename: May
authors.initials: M
authors.lastname: El-Sayed
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004534:Egypt; D008297:Male; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
chemical_list: D010936:Plant Extracts