title: Pharmacokinetic profile of valganciclovir in pediatric transplant recipients.
abstract: We evaluated the pharmacokinetic profile of intravenous ganciclovir and oral valganciclovir in transplant children. Median AUC0-24 concentrations obtained after intravenous and oral formulations were 22.9 µg•h/mL (range, 17-65.2) and 34.55 µg•h/mL (range, 20.8-84.2), respectively. After normalization on a 20 mg/kg/d valganciclovir dosage, the median AUC0-24 concentration was 37.6 µg•h/mL (range, 23.6-68).
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine, University of Montréal, Montreal, Quebec, Canada.
authors.forename: Elise
authors.initials: E
authors.lastname: Launay
authors.forename: Yves
authors.initials: Y
authors.lastname: Théôret
authors.forename: Catherine
authors.initials: C
authors.lastname: Litalien
authors.forename: Michel
authors.initials: M
authors.lastname: Duval
authors.forename: Fernando
authors.initials: F
authors.lastname: Alvarez
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Lapeyraque
authors.forename: Veronique
authors.initials: V
authors.lastname: Phan
authors.forename: Diane
authors.initials: D
authors.lastname: Larocque
authors.forename: Nancy
authors.initials: N
authors.lastname: Poirier
authors.forename: Valerie
authors.initials: V
authors.lastname: Lamarre
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D010949:Plasma / Q000737:chemistry; D014180:Transplantation; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir