title: Role of (p)ppGpp in biofilm formation by Enterococcus faecalis.
abstract: Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient ΔrelA, ΔrelQ, and ΔrelA ΔrelQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and proteolytic activity. E. faecalis lacking (p)ppGpp had a diminished capacity to sustain biofilm formation over an extended period of time and expressed abundant proteolytic activity.
authors.affiliation: Department of Oral Biology, Malmö University, Malmö, Sweden. ChavezdePaz@gde.uchc.edu
authors.forename: Luis E
authors.initials: LE
authors.lastname: Chávez de Paz
authors.forename: José A
authors.initials: JA
authors.lastname: Lemos
authors.forename: Claes
authors.initials: C
authors.lastname: Wickström
authors.forename: Christine M
authors.initials: CM
authors.lastname: Sedgley
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development*; D013293:Enterococcus faecalis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D017353:Gene Deletion; D006158:Guanosine Pentaphosphate / Q000378:metabolism*; D006159:Guanosine Tetraphosphate / Q000378:metabolism*; D050296:Microbial Viability; D010447:Peptide Hydrolases / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D006159:Guanosine Tetraphosphate; D006158:Guanosine Pentaphosphate; D010447:Peptide Hydrolases