title: In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Guizhen
authors.initials: G
authors.lastname: Ao
authors.forename: Qingri
authors.initials: Q
authors.lastname: Cao
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.forename: Jinghao
authors.initials: J
authors.lastname: Cui
mesh_terms: D019342:Acetic Acid; D000098:Acetophenones / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D019610:Cytoprotection; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D004338:Drug Combinations; D004339:Drug Compounding; D004355:Drug Stability; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004951:Esterification; D005753:Gastric Mucosa / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010316:Particle Size; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013678:Technology, Pharmaceutical / Q000379:methods; D014992:Xylenes
chemical_list: D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D020011:Protective Agents; D014992:Xylenes; D009569:Nitric Oxide; C013638:paeonol; D008315:Malondialdehyde; D015232:Dinoprostone; D019342:Acetic Acid; D007052:Ibuprofen