title: Modelling hepatitis C transmission over a social network of injecting drug users.
abstract: Hepatitis C virus (HCV) is a blood-borne virus that disproportionately affects people who inject drugs (PWIDs). Based on extensive interview and blood test data from a longitudinal study in Melbourne, Australia, we describe an individual-based transmission model for HCV spread amongst PWID. We use this model to simulate the transmission of HCV on an empirical social network of PWID. A feature of our model is that sources of infection can be both network neighbours and non-neighbours via "importing". Data-driven estimates of sharing frequency and rate of importing are provided. Compared to an appropriately calibrated fully connected network, the empirical network provides some protective effect on the time to primary infection. We also illustrate heterogeneities in incidence rate of infection, both across and within node degrees (i.e., number of network partners). We explore the reduced risk of infection from spontaneously clearing cutpoint nodes whose infection status oscillates, both in theory and in simulation. Further, we show our model-based estimate of per-event transmission probability largely agrees with previous estimates at the lower end of the range 1-3% commonly cited.
authors.affiliation: Department of Medicine-RMH, University of Melbourne, VIC 3010, Australia. drolls@unimelb.edu.au
authors.forename: D A
authors.initials: DA
authors.lastname: Rolls
authors.forename: G
authors.initials: G
authors.lastname: Daraganova
authors.forename: R
authors.initials: R
authors.lastname: Sacks-Davis
authors.forename: M
authors.initials: M
authors.lastname: Hellard
authors.forename: R
authors.initials: R
authors.lastname: Jenkinson
authors.forename: E
authors.initials: E
authors.lastname: McBryde
authors.forename: P E
authors.initials: PE
authors.lastname: Pattison
authors.forename: G L
authors.initials: GL
authors.lastname: Robins
mesh_terms: D006526:Hepatitis C / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D008954:Models, Biological; D016485:Needle Sharing / Q000009:adverse effects / Q000706:statistics & numerical data; D012008:Recurrence; D018570:Risk Assessment / Q000379:methods; D012944:Social Support; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000453:epidemiology; D013997:Time Factors; D014739:Victoria / Q000453:epidemiology