title: Synthesis of a new class of bis(thiourea)hydrazide pseudopeptides as potential inhibitors of β-sheet aggregation.
abstract: The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display "amphifinity", i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin, 12489 Berlin, Germany.
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Klein
authors.forename: Stefan
authors.initials: S
authors.lastname: Hecht
mesh_terms: D006834:Hydrazines / Q000138:chemical synthesis*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D014508:Urea / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D010455:Peptides; C029424:hydrazine; D014508:Urea