title: Is PCOS an inflammatory process?
abstract: PRO--PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. CON--Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers.
authors.affiliation: Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California 95817, USA. ajduleba@ucdavis.edu
authors.forename: Antoni J
authors.initials: AJ
authors.lastname: Duleba
authors.forename: Anuja
authors.initials: A
authors.lastname: Dokras
mesh_terms: D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D010053:Ovary / Q000276:immunology* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000276:immunology* / Q000378:metabolism; D014657:Vasculitis / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D017127:Glycation End Products, Advanced; D002097:C-Reactive Protein