title: Viral evolution in deep time: lentiviruses and mammals.
abstract: Lentiviruses are a distinctive genus of retroviruses that cause chronic, persistent infections in mammals, including humans. The emergence of pandemic HIV type-1 (HIV-1) infection during the late 20th century shaped a view of lentiviruses as 'modern' viruses. However, recent research has revealed an entirely different perspective, elucidating aspects of an evolutionary relationship with mammals that extends across many millions of years. Such deep evolutionary history is likely to be typical of many host-virus systems, fundamentally underpinning their interactions in the present day. For this reason, establishing the deep history of virus and host interaction is key to developing a fully informed approach to tackling viral diseases. Here, I use the example of lentiviruses to illustrate how paleovirological, geographic and genetic calibrations allow observations of virus and host interaction across a wide range of temporal and spatial scales to be integrated into a coherent ecological and evolutionary framework.
authors.affiliation: Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016, USA. rgifford@adarc.org
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gifford
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D008322:Mammals / Q000821:virology*; D010802:Phylogeny