title: Vilsmeier-type reaction of dimethylaminoalkenoyl cyclopropanes: one-pot access to 2,3-dihydrofuro [3,2-c]pyridin-4(5H)-ones.
abstract: A domino reaction of readily available 1-carbamoyl-1-dimethylaminoalkenoylcyclopropanes in the presence of triflic anhydride (Tf(2)O) in N,N-dimethylformamide (DMF) is described, which provides a facile one-pot access to 2,3-dihydrofuro[3,2-c]pyridin-4(5H)-ones via tandem formylation (Vilsmeier-type reaction), intramolecular cyclization, and ring-enlargement sequences.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D001688:Biological Products / Q000737:chemistry; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000475:Alkenes; D001688:Biological Products; D003521:Cyclopropanes; D011725:Pyridines