title: Impact of cyclooxygenase-2 in breast cancer.
abstract: Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Luebeck Campus, Ratzeburger Allee 160, 23538 Luebeck, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Hoellen
authors.forename: Katharina
authors.initials: K
authors.lastname: Kelling
authors.forename: Christine
authors.initials: C
authors.lastname: Dittmer
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
authors.forename: Michael
authors.initials: M
authors.lastname: Friedrich
authors.forename: Marc
authors.initials: M
authors.lastname: Thill
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000378:metabolism*; D045744:Cell Line, Tumor; D051546:Cyclooxygenase 2 / Q000096:biosynthesis / Q000502:physiology*; D005260:Female; D020869:Gene Expression Profiling; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D051379:Mice; D018345:Mice, Knockout; D009362:Neoplasm Metastasis; D011379:Prognosis; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014408:Biomarkers, Tumor; D011453:Prostaglandins; D051546:Cyclooxygenase 2