title: [Correction of hypoxia and its aftereffects in patients with acute cerebral insufficiency due to acute poisoning].
abstract: OBJECTIVE
  To examine efficacy of a substrate antihypoxic drug reamberine in patients with cerebral insufficiency (CI) caused by severe forms of acute poisoning.
  
  
  METHODS
  The study enrolled 60 patients (38 males, 22 females; mean age of the males 34.7 +/- 2.6 years, of the females - 28.4 +/- 3.2 years)admitted to the intensive care unit of St. Petersburg city center for treatment of acute poisoning for acute CI as a result of severe acute poisoning with neurotropic substances. The patients were divided into 2 groups matched by age, gender and severity of poisoning: group 1 (n = 32) received reamberin and standard treatment; group 2 (n = 28) received standard treatment alone.
  
  
  RESULTS
  The addition of reamberin to intensive treatment of acute CI alleviated severity of CI, enhanced recovery of functional activity of the brain, significantly reduced tissue hypoxia. All these positive effects improved clinical course of acute CI as shown by a shorter stay in the state of coma (reduction from 55 +/- 2.2 to 33 +/- 2.6 hours, shorter stay in the intensive care unit (reduction from 69.1 +/- 3.6 to 53.4 +/- 4.3 hours), reduced cost of the treatment.
  
  
  CONCLUSIONS
  In severe poisoning with neurotropic substances reamberin enhances correction of CI and increases tissue oxygen utilization.
mesh_terms: D000208:Acute Disease; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007362:Intensive Care Units; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D013386:Succinates / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C549374:Reamberin; D013386:Succinates; D008536:Meglumine