title: Progress on the biomarkers for tuberculosis diagnosis.
abstract: Tuberculosis (TB) remains a major threat to global health. Biomarkers derived from pathogen-host interaction can facilitate the monitoring of active TB. The recent progress regarding such biomarkers is summarized, including those can be used from serum, sputum, urine, or breath monitoring. A wide range of potential biomarkers such as protein antigens, cell-free nucleic acids, and lipoarabinomannose were compiled. The possible use of biomarkers for infection identification and monitoring drug efficacy are also presented.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Tiwei
authors.initials: T
authors.lastname: Fu
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood; D054884:Host-Pathogen Interactions; D006801:Humans; D007111:Immunity, Cellular; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D013183:Sputum / Q000378:metabolism; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D015415:Biomarkers; D016207:Cytokines