title: Determination of selected natural hormones and endocrine disrupting compounds in domestic wastewater treatment plants by liquid chromatography electrospray ionization tandem mass spectrometry after solid phase extraction.
abstract: A new analytical method for the simultaneous determination of two natural hormones (progesterone and estrone) and two selected endocrine disrupter compounds (EDCs) (diltiazem and carbamazepine (Cbz)) was developed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) after pre-concentration with solid phase extraction (SPE). Influent and effluent samples taken from five different wastewater treatment plants throughout Turkey namely Hurma/Antalya, Lara/Antalya, Kemer-1 and Kemer-2 and METU/Ankara were analyzed for their EDCs contents under the optimum conditions. All of the parameters in the pre-concentration step were optimized and the best recoveries for all compounds of interest were achieved at pH 7 (about 100%). Progesterone was not detected in any of the treatment plants while diltiazem was found in all samples with the exception of Lara effluent.
authors.affiliation: Middle East Technical University, Department of Environmental Engineering, 06531, Ankara, Turkey.
authors.forename: Melis
authors.initials: M
authors.lastname: Muz
authors.forename: M Selcen
authors.initials: MS
authors.lastname: Sönmez
authors.forename: Okan Tarık
authors.initials: OT
authors.lastname: Komesli
authors.forename: Sezgin
authors.initials: S
authors.lastname: Bakırdere
authors.forename: Celal Ferdi
authors.initials: CF
authors.lastname: Gökçay
mesh_terms: D002220:Carbamazepine / Q000032:analysis; D004110:Diltiazem / Q000032:analysis; D052244:Endocrine Disruptors / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004970:Estrone / Q000032:analysis*; D011374:Progesterone / Q000032:analysis*; D012722:Sewage / Q000032:analysis*; D052616:Solid Phase Extraction / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014421:Turkey; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry
chemical_list: D052244:Endocrine Disruptors; D012722:Sewage; D014874:Water Pollutants, Chemical; D004970:Estrone; D002220:Carbamazepine; D011374:Progesterone; D004110:Diltiazem