title: Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer.
abstract: Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed.
authors.affiliation: Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center at Dallas, 75390-9133, USA. jiang9.wu@utsouthwestern.edu
authors.forename: Jiang I
authors.initials: JI
authors.lastname: Wu
mesh_terms: D000199:Actins / Q000502:physiology; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000187:drug effects / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism* / Q000502:physiology; D004265:DNA Helicases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D006801:Humans; D007107:Immune System / Q000196:embryology; D051379:Mice; D009132:Muscles / Q000196:embryology; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D055495:Neurogenesis / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000502:physiology; D021122:Protein Subunits / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D015533:Transcriptional Activation; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D000199:Actins; C485486:Actl6a protein, mouse; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D021122:Protein Subunits; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000255:Adenosine Triphosphate; C084108:SMARCA4 protein, human; D004265:DNA Helicases