title: Disability weight of Clonorchis sinensis infection: captured from community study and model simulation.
abstract: BACKGROUND
  Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disability-adjusted life years (DALYs).
  
  
  RESULTS
  According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5-14, 15-29, 30-44, 45-59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation.
  
  
  CONCLUSIONS
  The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection.
authors.affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China.
authors.forename: Men-Bao
authors.initials: MB
authors.lastname: Qian
authors.forename: Ying-Dan
authors.initials: YD
authors.lastname: Chen
authors.forename: Yue-Yi
authors.initials: YY
authors.lastname: Fang
authors.forename: Long-Qi
authors.initials: LQ
authors.lastname: Xu
authors.forename: Ting-Jun
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Tan
authors.initials: T
authors.lastname: Tan
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Zhou
authors.forename: Guo-Fei
authors.initials: GF
authors.lastname: Wang
authors.forename: Tie-Wu
authors.initials: TW
authors.lastname: Jia
authors.forename: Guo-Jing
authors.initials: GJ
authors.lastname: Yang
authors.forename: Xiao-Nong
authors.initials: XN
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China; D002761:Cholangitis; D003003:Clonorchiasis / Q000469:parasitology / Q000473:pathology*; D003004:Clonorchis sinensis / Q000302:isolation & purification*; D003198:Computer Simulation; D017281:Cost of Illness; D005243:Feces / Q000469:parasitology; D005260:Female; D042882:Gallstones; D006801:Humans; D008297:Male; D008875:Middle Aged; D058069:Neglected Diseases / Q000469:parasitology* / Q000473:pathology*; D019057:Quality-Adjusted Life Years; D011795:Surveys and Questionnaires