title: Integrating VA's NDF-RT drug terminology with PharmGKB: preliminary results.
abstract: Biomedical terminology and vocabulary standards play an important role in enabling consistent, comparable, and meaningful sharing of data within and across institutional boundaries, as well as ensuring semantic interoperability. The Veterans Affairs (VA) National Drug File Reference Terminology (NDF-RT) is a federally recommended standardized terminology resource encompassing medications, ingredients, and a hierarchy for high-level drug classes. In this study, we investigate the drug-disease relationships in NDF-RT and determine how PharmGKB can be leveraged to augment NDF-RT, and vice-versa. Our preliminary results indicate that with additional curation and analyses, information contained in both knowledge resources can be mutually integrated.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. pathak.jyotishman@mayo.edu
authors.forename: Jyotishman
authors.initials: J
authors.lastname: Pathak
authors.forename: Laura C
authors.initials: LC
authors.lastname: Weiss
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Durski
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhu
authors.forename: Robert R
authors.initials: RR
authors.lastname: Freimuth
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Chute
mesh_terms: D019295:Computational Biology; D004194:Disease / Q000235:genetics; D004358:Drug Therapy; D006801:Humans; D051188:Knowledge Bases; D004364:Pharmaceutical Preparations; D010597:Pharmacogenetics / Q000706:statistics & numerical data*; D010599:Pharmacokinetics; D009626:Terminology as Topic; D014481:United States; D014493:United States Department of Veterans Affairs
chemical_list: D004364:Pharmaceutical Preparations