title: Selective decreased grey matter volume of the pain-matrix network in cluster headache.
abstract: OBJECTIVE
  We assessed the pattern of regional white matter and grey matter abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM).
  
  
  METHODS
  Using a 3.0 Tesla scanner, dual-echo, diffusion tensor and 3D T1-weighted scan were acquired from 15 patients with episodic CH and 19 healthy controls. TBSS analysis was performed using the FMRIB's Diffusion Toolbox. VBM was performed on the 3D T1-weighted images using SPM8.
  
  
  RESULTS
  No diffusivity and volumetry abnormalities of brain white matter were detected in CH patients. Compared with controls, CH patients showed decreased grey matter volume in the right thalamus, head of the right caudate nucleus, right precentral gyrus, right posterior cingulate cortex, bilateral middle frontal gyrus, right middle temporal gyrus, left inferior parietal lobule and left insula (p < 0.001). They also had increased grey matter volume of the right cuneus. The results did not change after hemisphere mirroring in the five patients with left lateralized attacks. The decreased left middle frontal gyrus volume was significantly correlated with disease duration (r = -0.79, p < 0.001).
  
  
  CONCLUSIONS
  CH patients experience tissue abnormalities of grey matter regions that are part of the antinociceptive system, which is shared with other chronic pain conditions.
authors.affiliation: Vita-Salute San Raffaele University, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Absinta
authors.forename: Maria A
authors.initials: MA
authors.lastname: Rocca
authors.forename: Bruno
authors.initials: B
authors.lastname: Colombo
authors.forename: Andrea
authors.initials: A
authors.lastname: Falini
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Comi
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D003027:Cluster Headache / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007031:Hypothalamus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology; D013788:Thalamus / Q000473:pathology