title: Mitochondria-ros crosstalk in the control of cell death and aging.
abstract: Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as "redox messengers" in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a "balance of power," directing the cell towards life or death.
authors.affiliation: Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Marchi
authors.forename: Carlotta
authors.initials: C
authors.lastname: Giorgi
authors.forename: Jan M
authors.initials: JM
authors.lastname: Suski
authors.forename: Chiara
authors.initials: C
authors.lastname: Agnoletto
authors.forename: Angela
authors.initials: A
authors.lastname: Bononi
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonora
authors.forename: Elena
authors.initials: E
authors.lastname: De Marchi
authors.forename: Sonia
authors.initials: S
authors.lastname: Missiroli
authors.forename: Simone
authors.initials: S
authors.lastname: Patergnani
authors.forename: Federica
authors.initials: F
authors.lastname: Poletti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rimessi
authors.forename: Jerzy
authors.initials: J
authors.lastname: Duszynski
authors.forename: Mariusz R
authors.initials: MR
authors.lastname: Wieckowski
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton