title: p-Terphenyl and diterpenoid metabolites from endophytic Aspergillus sp. YXf3.
abstract: Six new p-terphenyl derivatives, named 4″-deoxy-3-hydroxyterphenyllin (1), 4″-deoxy-5'-desmethyl-terphenyllin (2), 5'-desmethylterphenyllin (3), 4″-deoxycandidusin A (4), 4,5-dimethoxycandidusin A (5), and terphenolide (6), four new diterpenoids with norcleistanthane (aspergiloid A (12) and aspergiloid B (13)), cleistanthane (aspergiloid C (14)), and isopimarane (aspergiloid D (15)) type skeletons, and five known p-terphenyl compounds (7-11) were isolated from the fermentation broth of the plant endophytic fungus Aspergillus sp. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. Compounds 4, 6, 7, and 9 displayed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.34 to 9.17 μM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Tong
authors.initials: T
authors.lastname: Yan
authors.forename: Ye
authors.initials: Y
authors.lastname: Guo
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Jiao
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020441:Ginkgo biloba / Q000382:microbiology; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D013730:Terphenyl Compounds; C010790:terphenyllin; D009439:Neuraminidase