title: Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?
abstract: Reduced cavernosal arterial inflow has been hypothesized to be the likely cause of erectile dysfunction after kidney transplants in recipients revascularized through end-to-end anastomosis to the internal iliac artery, suggesting that end-to-side anastomosis at the external iliac artery is preferable. The aim of this study was to prospectively evaluate the effect of the use of the external iliac artery on erectile function, hormone profiles and penile blood flow by evaluating changes in penile colour Doppler ultrasound parameters in a consecutive series of 22 recipients before and after end-to-side external iliac artery transplantation. The mean International Index of Erectile Function-Erectile Function (IIEF-EF) domain score decreased significantly 3 months after transplant (18.09±6.33 vs. 22.50±7.09, P=0.01). The reduction in peak systolic velocity (PSV) was significant for the cavernous artery homolateral to the side of transplant (42.60±18.77 vs. 52.01±19.91, P=0.01). The mean postoperative end diastolic velocity (EDV) did not differ significantly from the preoperative value (P=0.74). No statistical differences were found in the serum levels of testosterone or prolactin. Kidney grafts anastomosed at the external iliac artery produced significant (P=0.01) reductions in arterial inflow at the homolateral cavernosal artery that remained above the normal threshold. Whether these haemodynamic changes can explain the worsening of postoperative erectile function remains to be proven.
authors.affiliation: Department of Urology-1, A.O.U.S. Giovanni Battista, University of Turin, Turin 10126, Italy. paolo.gontero@unito.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Gontero
authors.forename: Marco
authors.initials: M
authors.lastname: Oderda
authors.forename: Claudia
authors.initials: C
authors.lastname: Filippini
authors.forename: Francesco
authors.initials: F
authors.lastname: Fontana
authors.forename: Elisa
authors.initials: E
authors.lastname: Lazzarich
authors.forename: Piero
authors.initials: P
authors.lastname: Stratta
authors.forename: Ernesto
authors.initials: E
authors.lastname: Turello
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tizzani
authors.forename: Bruno
authors.initials: B
authors.lastname: Frea
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods; D001783:Blood Flow Velocity; D007172:Erectile Dysfunction / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007083:Iliac Artery / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010413:Penis / Q000098:blood supply* / Q000000981:diagnostic imaging; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult