title: Bacterial invasion of vascular cell types: vascular infectology and atherogenesis.
abstract: To portray the chronic inflammation in atherosclerosis, leukocytic cell types involved in the immune response to invading pathogens are often the focus. However, atherogenesis is a complex pathological deterioration of the arterial walls, where vascular cell types are participants with regards to deterioration and disease. Since other recent reviews have detailed the role of both the innate and adaptive immune response in atherosclerosis, herein we will summarize the latest developments regarding the association of bacteria with vascular cell types: infections as a risk factor for atherosclerosis; bacterial invasion of vascular cell types; the atherogenic sequelae of bacterial presence such as endothelial activation and blood clotting; and the identification of the species that are able to colonize this niche. The evidence of a polybacterial infectious component of the atheromatous lesions opens the doors for exploration of the new field of vascular infectology and for the study of atherosclerosis microbiome.
authors.affiliation: Section of Oral & Diagnostic Sciences, Columbia University Medical Center, 630 West 168 Street, P&S Box 20, New York, NY 10032, USA. ekozarov@gmail.com
authors.forename: Emil
authors.initials: E
authors.lastname: Kozarov
mesh_terms: D001161:Arteriosclerosis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D001424:Bacterial Infections; D002319:Cardiovascular System / Q000382:microbiology* / Q000473:pathology; D002908:Chronic Disease; D003713:Dendritic Cells; D004730:Endothelium, Vascular / Q000382:microbiology / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D007249:Inflammation; D009203:Myocardial Infarction / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D010510:Periodontal Diseases / Q000382:microbiology; D014481:United States / Q000453:epidemiology