title: IgG4-related airway involvement which developed in a patient receiving corticosteroid therapy for autoimmune pancreatitis.
abstract: A 66-year-old man was diagnosed with autoimmune pancreatitis in February 2009 and started 40 mg of oral prednisolone followed by a maintenance dose of 5 mg daily. The patient developed a cough in October 2010 and visited our division. He had a high serum concentration of immunoglobulin (Ig) G4 and his chest computed tomography showed airway stenosis without bilateral hilar lymphadenopathy (BHL). The bronchial biopsy specimens revealed lymphoplasmacytic infiltrations with IgG4-positive/IgG-positive plasma cells of more than 50%. Thus, we diagnosed the airway lesion with IgG4-related airway involvement. This is the first report of a patient with IgG4-related airway involvement without BHL.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Japan. yama5252@hsp.md.shinshu-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nomura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Ushiki
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Mai
authors.initials: M
authors.lastname: Iwaya
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawakami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hamano
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawa
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000368:Aged; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001982:Bronchial Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy*; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D011239:Prednisolone