title: Dual-layer wavelet SVM for predicting protein structural class via the general form of Chou's pseudo amino acid composition.
abstract: A prior knowledge of protein structural class can provide useful information about its overall structure. So, it is vitally important to develop a computational prediction method for fast and accurately determining the protein structural class. In this paper, a dual-layer wavelet support vector machine (WSVM) is presented via the general form of Chou's pseudo amino acid composition, which is featured by introducing wavelet as a kernel and making decisions by the fusion from three individual classifiers. As a demonstration, the rigorous jackknife cross-validation tests were performed on two benchmark datasets, including the more challenging 25PDB dataset. Our success rates were reliable, and it has not escaped from our notice that the present method has specific ability to predict the most difficult case of α+β class. The program developed can be acquired freely on request from the authors.
authors.affiliation: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, P.R China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Shen
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zou
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry* / Q000235:genetics; D019295:Computational Biology; D006801:Humans; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000145:classification*; D020539:Sequence Analysis, Protein; D012984:Software; D060388:Support Vector Machine
chemical_list: D000596:Amino Acids; D011506:Proteins