title: Developmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians.
abstract: Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.
authors.affiliation: Department of Experimental Pathology, University of Pisa, Italy.
authors.forename: Vanna
authors.initials: V
authors.lastname: Fierabracci
authors.forename: Maria
authors.initials: M
authors.lastname: Franzini
authors.forename: Angelo
authors.initials: A
authors.lastname: Baggiani
authors.forename: Irene
authors.initials: I
authors.lastname: Fornaciari
authors.forename: Silvia
authors.initials: S
authors.lastname: Burchielli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Urciuoli
authors.forename: Roberta
authors.initials: R
authors.lastname: Lamanna
authors.forename: Simone
authors.initials: S
authors.lastname: Lapi
authors.forename: Francesca
authors.initials: F
authors.lastname: Nocchi
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Iorio
authors.forename: Michele
authors.initials: M
authors.lastname: Emdin
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pompella
authors.forename: Aldo
authors.initials: A
authors.lastname: Paolicchi
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers / Q000097:blood; D002850:Chromatography, Gel / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000201:enzymology* / Q000254:growth & development*; D051379:Mice; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013552:Swine; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000302:isolation & purification
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase