title: Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus.
abstract: A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.
authors.affiliation: Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Czakó
authors.forename: Robert L
authors.initials: RL
authors.lastname: Atmar
authors.forename: Antone R
authors.initials: AR
authors.lastname: Opekun
authors.forename: Mark A
authors.initials: MA
authors.lastname: Gilger
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.forename: Mary K
authors.initials: MK
authors.lastname: Estes
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D005759:Gastroenteritis / Q000276:immunology* / Q000821:virology; D006385:Hemagglutination Inhibition Tests / Q000379:methods; D006387:Hemagglutination, Viral / Q000276:immunology*; D006801:Humans; D009663:Norwalk virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral