title: Highly diastereoselective synthesis of enantiopure β-trifluoromethyl β-amino alcohols from chiral trifluoromethyl oxazolidines (Fox).
abstract: The organolithium species addition to 2-hydroxymethyl fluorinated oxazolidines (Fox) provides a highly diastereoselective and straightforward route for the synthesis of enantiopure trifluoromethyl β-amino alcohols quaternarized at the β-position.
authors.affiliation: Laboratoire Synthèse Organique Sélective et Chimie bioOrganique (SOSCO), Université de Cergy-Pontoise, 5 Mail Gay-Lussac 95000 Cergy-Pontoise cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Simon
authors.forename: Evelyne
authors.initials: E
authors.lastname: Chelain
authors.forename: Thierry
authors.initials: T
authors.lastname: Brigaud
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis*; D017611:Fluorine Compounds / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D017611:Fluorine Compounds; D007097:Imines; D010080:Oxazoles; C064210:oxazolidine