title: Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.
abstract: The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.
authors.affiliation: Institut des Biomolécules Max Mousseron, Faculté de Pharmacie, 34093, Montpellier, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: Ouahiba
authors.initials: O
authors.lastname: Hocine
authors.forename: David
authors.initials: D
authors.lastname: Brevet
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Laurence
authors.initials: L
authors.lastname: Raehm
authors.forename: Sébastien
authors.initials: S
authors.lastname: Richeter
authors.forename: Virginie
authors.initials: V
authors.lastname: Charasson
authors.forename: Bernard
authors.initials: B
authors.lastname: Loock
authors.forename: Alain
authors.initials: A
authors.lastname: Morère
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D011992:Endosomes / Q000378:metabolism; D019793:Fluorescein / Q000737:chemistry / Q000378:metabolism; D005690:Galactose / Q000737:chemistry / Q000378:metabolism*; D045325:HCT116 Cells; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D018613:Microscopy, Confocal; D053758:Nanoparticles; D036103:Nanotechnology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D016062:Porosity; D011956:Receptors, Cell Surface / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
chemical_list: D004337:Drug Carriers; D017319:Photosensitizing Agents; D011956:Receptors, Cell Surface; C039707:galactose receptor; D012822:Silicon Dioxide; D019793:Fluorescein; D005690:Galactose