title: Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response.
abstract: In Saccharomyces cerevisiae, adaptation to hypoxia/anaerobiosis requires the transcriptional induction or derepression of multiple genes organized in regulons controlled by specific transcriptional regulators. Ixr1p is a transcriptional regulatory factor that causes aerobic repression of several hypoxic genes (COX5B, TIR1, and HEM13) and also the activation of HEM13 during hypoxic growth. Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative Δixr1, grown in aerobic and hypoxic conditions, reveals differential regulation of genes related not only to the hypoxic and oxidative stress responses but also to the re-adaptation of catabolic and anabolic fluxes in response to oxygen limitation. The function of Ixr1p in the transcriptional regulation of genes from the sulfate assimilation pathway and other pathways producing α-keto acids is of biotechnological importance for industries based on yeast-derived fermentation products.
authors.affiliation: Departamento de Biología Celular y Molecular, F. Ciencias, Universidad de A Coruña, Campus de A Zapateira s/n. A, Coruña 15071, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Vizoso-Vázquez
authors.forename: Mónica
authors.initials: M
authors.lastname: Lamas-Maceiras
authors.forename: Manuel
authors.initials: M
authors.lastname: Becerra
authors.forename: M Isabel
authors.initials: MI
authors.lastname: González-Siso
authors.forename: Esther
authors.initials: E
authors.lastname: Rodríguez-Belmonte
authors.forename: M Esperanza
authors.initials: ME
authors.lastname: Cerdán
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; C082364:IXR1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D010100:Oxygen