title: Skin biopsy-proven flecainide-induced neuropathy.
abstract: Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy.
authors.affiliation: Department of Neurology, George Washington University, Washington, DC, USA.
authors.forename: Ahmet Z
authors.initials: AZ
authors.lastname: Burakgazi
authors.forename: Michael
authors.initials: M
authors.lastname: Polydefkis
authors.forename: Ahmet
authors.initials: A
authors.lastname: Höke
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001706:Biopsy / Q000379:methods*; D005424:Flecainide / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D012867:Skin / Q000473:pathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide