title: Decreased high-density lipoprotein cholesterol levels in polyarticular juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To investigate the prevalence of dyslipoproteinemia in a homogeneous cohort of polyarticular juvenile idiopathic arthritis patients.
  
  
  METHODS
  Based on the National Cholesterol Education Program, fasting lipoprotein levels and risk levels for coronary artery disease were determined in 28 patients with polyarticular juvenile idiopathic arthritis. The exclusion criteria included diabetes, thyroid dysfunction, smoking, proteinuria, lipid-lowering drugs, and hormone/diuretic therapy. Disease activity, disease duration, and therapy with corticosteroids and/or chloroquine were defined at the time of lipid measurements.
  
  
  RESULTS
  Dyslipoproteinemia was identified in 20 of the 28 (71%) patients with polyarticular juvenile idiopathic arthritis. The primary lipoprotein risk factor was decreased high-density lipoprotein cholesterol (57%), followed by elevated levels of low-density lipoprotein cholesterol (18%), triglycerides (14%), and total cholesterol (7%). The male patients had decreased high-density lipoprotein cholesterol levels than the female patients (p<0.05). The incidence of decreased high-density lipoprotein cholesterol levels did not seem to be affected by disease activity or therapy because the incidence was similar in patients with active or inactive disease, with or without corticosteroid use and with or without chloroquine use. In addition, the frequency of decreased high-density lipoprotein cholesterol levels was similar in patients with short (≤5 years) vs. long (>5 years) disease duration.
  
  
  CONCLUSIONS
  Dyslipoproteinemia is highly prevalent in patients with polyarticular juvenile idiopathic arthritis and is primarily related to decreased high-density lipoprotein cholesterol levels; therefore, early intervention is essential.
authors.affiliation: Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Brazil.
authors.forename: Roberta Gonçalves
authors.initials: RG
authors.lastname: Marangoni
authors.forename: Andre L
authors.initials: AL
authors.lastname: Hayata
authors.forename: Eduardo F
authors.initials: EF
authors.lastname: Borba
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Azevedo
authors.forename: Eloisa
authors.initials: E
authors.lastname: Bonfá
authors.forename: Claudia Goldenstein
authors.initials: CG
authors.lastname: Schainberg
mesh_terms: D000328:Adult; D001171:Arthritis, Juvenile / Q000097:blood* / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors
chemical_list: D008076:Cholesterol, HDL