title: Backfiltration: past, present and future.
abstract: Backfiltration has been recognized to be present in most diffusive-convective therapies. Although initially considered an inconvenience due to its implications in transport of contaminants in dialysate to the blood compartment, the availability of ultrapure dialysate has prompted a fresh look at the phenomenon of backfiltration with the possibility of exploiting it to further enhance the convective clearance of middle and large molecules. This review discusses the historical aspects of backfiltration, its mechanisms and influencing factors, and subsequently the different hemodialysis techniques in relation to increasing or diminishing this phenomenon.
authors.forename: Armando Vazquez
authors.initials: AV
authors.lastname: Rangel
authors.forename: Jeong Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Manish
authors.initials: M
authors.lastname: Kaushik
authors.forename: Francesco
authors.initials: F
authors.lastname: Garzotto
authors.forename: Mauro
authors.initials: M
authors.lastname: Neri
authors.forename: Dinna N
authors.initials: DN
authors.lastname: Cruz
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D015314:Dialysis Solutions; D006801:Humans; D008567:Membranes, Artificial; D010539:Permeability; D006435:Renal Dialysis / Q000379:methods* / Q000639:trends*; D051437:Renal Insufficiency / Q000628:therapy
chemical_list: D015314:Dialysis Solutions; D008567:Membranes, Artificial