title: [Multiple intracranial lesions: a clinicalpathologic study of 62 cases].
abstract: OBJECTIVE
  To study the clinicalpathologic features of intracranial multiple lesions.
  
  
  METHODS
  The clinical, radiologic and pathologic features of intracranial multiple lesions in 62 cases during the period from 2005 to 2009 in Xuanwu Hospital were retrospectively reviewed.
  
  
  RESULTS
  There were 32 males and 30 females in 62 cases. The mean age of seize onset and duration of disease were 37.4-year-old and 11.6 months, respectively. The lesions could affect cerebral hemisphere, basal ganglia, brain stem, cerebellum and other parts, most lesions were located above the tentorium. Pathological diagnosis as follows: 13 patients with glioma; metastatic tumors in 13 cases; 12 cases of central nervous system infection; immune-mediated inflammatory demyelinating disease in 8 cases; 5 cases of primary lymphoma of central nervous system; primary angiitis of the central nervous system 3 cases; mitochondrial encephalopathy 2 cases; vein thrombosis in 2 cases; Rosai-Dorfman disease in 2 cases; 2 case of radiation encephalopathy. Among them, mitochondrial encephalopathy and vein thrombosis lesions located in the cortex; metastatic tumor and blood-borne infection mainly involving junction of grey and white matter; glioma, radiation encephalopathy and demyelinating disease include white matter lesions; vascular inflammation showed cortical and subcortical white matter lesions.
  
  
  CONCLUSIONS
  A variety of tumor and non-neoplastic diseases can be expressed in intracranial multiple lesions, which gliomas, metastatic tumor and central nervous system infections are more common. In order to improve the diagnosis of intracranial multiple lesions, active work in the brian biopsy, study the clinical, imaging and pathological findings must be closely.
authors.affiliation: Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Yue-shan
authors.initials: YS
authors.lastname: Piao
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Guo-cai
authors.initials: GC
authors.lastname: Tang
authors.forename: Li-feng
authors.initials: LF
authors.lastname: Wei
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: De-hong
authors.initials: DH
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D020306:Tuberculosis, Central Nervous System / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D055815:Young Adult