title: Beyond fat mass: exploring the role of adipokines in rheumatic diseases.
abstract: The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert potent modulatory actions on target tissues involved in rheumatic diseases including cartilage, synovial, bone and immune cells. The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE).
authors.affiliation: Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases, SERGAS, Institute of Medical Research IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Gómez
authors.forename: Veronica
authors.initials: V
authors.lastname: López
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.forename: Juan Jesus
authors.initials: JJ
authors.lastname: Gómez-Reino
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism; D054392:Adipokines / Q000276:immunology* / Q000378:metabolism; D052436:Adipose Tissue, White / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000073861:Apelin; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D019902:Chondrocytes / Q000187:drug effects / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism; D000071068:Lipocalin-2; D054834:Lipocalins / Q000276:immunology / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000503:physiopathology; D054409:Nicotinamide Phosphoribosyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D010003:Osteoarthritis / Q000276:immunology / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000378:metabolism; D012216:Rheumatic Diseases / Q000276:immunology* / Q000503:physiopathology
chemical_list: C115436:APLN protein, human; D000209:Acute-Phase Proteins; D054392:Adipokines; D000073861:Apelin; D018925:Chemokines; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; C478630:RARRES2 protein, human; D054409:Nicotinamide Phosphoribosyltransferase