title: Acute hemicerebellitis in a pediatric patient: a case report of a serial MR spectroscopy study.
abstract: The changes in the signals for brain metabolites in the left cerebellum of a 14-year-old boy with acute hemicerebellitis were monitored using proton magnetic resonance spectroscopy (MRS). From the onset of disease treatment to long-term follow-up, MRS data were serially acquired from the left and right cerebella, basal ganglia (BG), and centrum semiovale (CS). Large fluctuations in his MRS signals were observed in the left cerebellum. At onset (first day), his glutamate/glutamine complex signals were increased (>mean ± 2 standard deviations [SD] of the control), and those for N-acetylaspartate/N-acetylaspartylglutamate and myo-inositol were decreased (<2SD). By the 25th day, these signals had recovered to normal levels, while those for choline (Cho) were increased. In other locations, the signals for mIns in the BG and Cho in the CS were decreased on the seventh day. By the 201st day, the levels of all metabolites in all locations had recovered to within ± 2SD of the control levels. In vivo proton MRS monitoring demonstrated reversible metabolite changes associated with acute hemicerebellitis, which should contribute to its differential diagnosis from brain tumors.
authors.affiliation: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Moyoko
authors.initials: M
authors.lastname: Tomiyasu
authors.forename: Noriko
authors.initials: N
authors.lastname: Aida
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Mitani
authors.forename: Takahito
authors.initials: T
authors.lastname: Wada
authors.forename: Takayuki
authors.initials: T
authors.lastname: Obata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Osaka
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002526:Cerebellar Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006261:Headache / Q000209:etiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone