title: Mathematical morphology-based approach to the enhancement of morphological features in medical images.
abstract: BACKGROUND
  Medical image processing is essential in many fields of medical research and clinical practice because it greatly facilitates early and accurate detection and diagnosis of diseases. In particular, contrast enhancement is important for optimal image quality and visibility. This paper proposes a new image processing method for enhancing morphological features of masses and other abnormalities in medical images.
  
  
  METHODS
  The proposed method involves two steps: (1) selective extraction of target features by mathematical morphology and (2) enhancement of the extracted features by two contrast modification techniques.
  
  
  RESULTS
  The goal of the proposed method is to enable enhancement of fine morphological features of a lesion region with high suppression of surrounding tissues. The effectiveness of the method was evaluated in quantitative terms of the contrast improvement ratio. The results clearly show that the method outperforms five conventional contrast enhancement methods. The effectiveness and usefulness of the proposed method were further demonstrated by application to three types of medical images: a mammographic image, a chest radiographic image, and a retinal image.
  
  
  CONCLUSIONS
  The proposed method enables specific extraction and enhancement of mass lesions, which is essential for clinical diagnosis based on medical image analysis. Thus, the method can be expected to achieve automatic recognition of lesion location and quantitative analysis of legion morphology.
authors.affiliation: Imaging Science Division, Center for Novel Science Initiatives, National Institutes of Natural Sciences, Toranomon 4-3-13, Minato-ku, Tokyo, 105-0001, Japan. y.kimori@nao.ac.jp.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kimori