title: Factors associated with development of prolonged QRS duration over 20 years in healthy young adults: the Coronary Artery Risk Development in Young Adults study.
abstract: BACKGROUND
  Data describing factors associated with the development of a prolonged QRS duration (QRSd) from young adulthood to middle age are sparse.
  
  
  METHODS
  We analyzed 12-lead electrocardiograms (ECGs) from the Coronary Artery Risk Development in Young Adults study over 20 years. We performed logistic regression to examine the associations of baseline (year 0) or average (years 0-20) risk factors with incident prolonged QRSd (QRS >100 milliseconds).
  
  
  RESULTS
  We included 2537 participants (57.2% women, 44.7% black; mean age, 25 years); 292 (11.5%) developed incident QRSd greater than 100 milliseconds by year 20. In univariate analyses, baseline covariates associated with incident QRSd prolongation included white race, male sex, ECG-left ventricular mass index, and baseline QRSd. Similar results were observed after multivariable adjustment.
  
  
  CONCLUSIONS
  We found no long-term associations of modifiable risk factors with incident QRSd >100 milliseconds. Men, whites, and those with higher ECG-left ventricular mass index and QRSd in young adulthood are at an increased risk for incident prolonged QRSd by middle age.
authors.affiliation: Department of Medicine, Division of Cardiology, Section of Electrophysiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. l-ilkhanoff@northwestern.edu
authors.forename: Leonard
authors.initials: L
authors.lastname: Ilkhanoff
authors.forename: Elsayed Z
authors.initials: EZ
authors.lastname: Soliman
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ning
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
authors.forename: Donald M
authors.initials: DM
authors.lastname: Lloyd-Jones
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D012307:Risk Factors