title: Diterpenoids including a novel dimeric conjugate from Salvia leriaefolia.
abstract: Salvialeriafone (1), a novel diterpene-norditerpene conjugate, was isolated from Salvia leriaefolia. Additionally, two new abietane-type diterpenoids, salvialerial (2) and salvialerione (3), as well as four known compounds, sugiol (4), salvicanaric acid (5), dehydroroyleanone (6), and cariocal (7), were isolated and identified. Their structures were determined by spectroscopic data analyses. Known compounds were isolated from this plant for the first time. Compounds 1, 5, 6, and 7 exhibited IN VITRO antiproliferative activity against the human cervical cancer cell line (Hela), while 6 showed cytotoxicity against the human prostate cancer cell line (PC3).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Amjad
authors.initials: A
authors.lastname: Hussain
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.forename: Samina A
authors.initials: SA
authors.lastname: Sattar
authors.forename: Syed A
authors.initials: SA
authors.lastname: Ayatollahi
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Al-Majid
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007492:Iran; D008297:Male; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy; D027544:Salvia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C501333:sugiol