title: Teasing out the role of ATP in immune responses. See referenced article, J. Biol. Chem. 2011, 286, 44776–44787. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
mesh_terms: D000244:Adenosine Diphosphate / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D019898:Autocrine Communication / Q000187:drug effects / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology*; D015936:Complement C5a / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011554:Pseudopodia / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D058912:Purinergic P2Y Receptor Agonists / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D058925:Receptors, Purinergic P2Y12 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D058473:Receptors, Purinergic P2Y2 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
chemical_list: C548577:P2ry12 protein, mouse; D058912:Purinergic P2Y Receptor Agonists; D058925:Receptors, Purinergic P2Y12; D058473:Receptors, Purinergic P2Y2; D000244:Adenosine Diphosphate; D015936:Complement C5a; D000255:Adenosine Triphosphate; D019869:Phosphatidylinositol 3-Kinases; D048051:p38 Mitogen-Activated Protein Kinases