title: Synthesis of tricyclic nitrogen heterocycles by a sequence of palladium-catalyzed N-H and C(sp3)-H arylations.
abstract: A range of tricyclic nitrogen heterocycles were synthesized in a straightforward and efficient manner via a sequence involving palladium-catalyzed N-arylation and C(sp(3))-H arylation as the key steps. Whereas the C(sp(3))-H arylation furnished fused 6,5,6-membered ring systems efficiently, the formation of the more strained 6,5,5-membered systems proved to be more challenging and required a subtle adjustment of the reaction conditions.
authors.affiliation: CNRS UMR 5246 - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université Claude Bernard Lyon 1 , CPE Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Guyonnet
authors.forename: Olivier
authors.initials: O
authors.lastname: Baudoin
mesh_terms: D000147:Acids, Heterocyclic / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000147:Acids, Heterocyclic; D017672:Nitrogen Compounds; D010165:Palladium