title: Chemokine receptors in the pathogenesis and therapy of psoriasis.
abstract: Chemokine receptors are G-protein-coupled, seven-transmembrane-spanning surface receptors that play key roles in cell trafficking, cell motility, and survival. These receptors are activated by small molecular weight chemotactic cytokines called chemokines. Chemokine receptors and their corresponding chemokine ligands play roles in the migration and localization of normal T cells (and other cells) during physiological responses in inflamed or infected skin. In psoriasis, the chemokine receptor CCR6 is expressed on the Th17 cells and γδ T cells, which produce a variety of cytokines (IL17 and IL22 among others), that play a role in the immunological activation. CCR6 and its ligand, CCL20, are highly expressed in psoriatic skin lesion and CCR6 is essential for the development of the psoriasiform phenotype following IL23 injection in mouse skin. In this review, we focus on the roles of chemokine receptors, particularly of CCR6, in the pathogenesis of psoriasis and discuss chemokine receptors as novel therapeutic targets for psoriasis.
authors.affiliation: Department of Dermatology, Medical College of Wisconsin, WI, USA. mabuchi@is.icc.u-tokai.ac.jp
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Chang
authors.forename: Suzanne
authors.initials: S
authors.lastname: Quinter
authors.forename: Sam T
authors.initials: ST
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D002465:Cell Movement; D054418:Chemokine CCL20 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D008024:Ligands; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008954:Models, Biological; D011565:Psoriasis / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism; D054399:Receptors, CCR6 / Q000378:metabolism; D019707:Receptors, Chemokine / Q000502:physiology*; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology; D000097043:Interleukin-22
chemical_list: D000911:Antibodies, Monoclonal; D054418:Chemokine CCL20; D016207:Cytokines; D007378:Interleukins; D008024:Ligands; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054399:Receptors, CCR6; D019707:Receptors, Chemokine; D000097043:Interleukin-22; C106311:CCR6 protein, human