title: Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.
abstract: The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.
authors.affiliation: Department of Pediatrics, Geneva Children's Hospital, Geneva, Switzerland. karine.anastaze@hcuge.ch
authors.forename: K
authors.initials: K
authors.lastname: Anastaze Stelle
authors.forename: D C
authors.initials: DC
authors.lastname: Belli
authors.forename: P
authors.initials: P
authors.lastname: Parvex
authors.forename: E
authors.initials: E
authors.lastname: Girardin
authors.forename: A
authors.initials: A
authors.lastname: Giroud
authors.forename: B
authors.initials: B
authors.lastname: Wildhaber
authors.forename: V A
authors.initials: VA
authors.lastname: McLin
mesh_terms: D000293:Adolescent; D000959:Antihypertensive Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000494:pharmacology; D017608:Chromium Compounds / Q000494:pharmacology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007223:Infant; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology*; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D016559:Tacrolimus / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D002712:Chlorides; D017608:Chromium Compounds; D007166:Immunosuppressive Agents; C017133:chromous chloride; D016559:Tacrolimus