title: Relative contributions of porosity and mineralized matrix properties to the bulk axial ultrasonic wave velocity in human cortical bone.
abstract: Velocity of ultrasound waves has proved to be a useful indicator of bone biomechanical competence. A detailed understanding of the dependence of ultrasound parameters such as velocity on bone characteristics is a key to the development of bone quantitative ultrasound (QUS). The objective of this study is to investigate the relative contributions of porosity and mineralized matrix properties to the bulk compressional wave velocity (BCV) along the long bone axis. Cross-sectional slabs from the diaphysis of four human femurs were included in the study. Seven regions of interest (ROIs) were selected in each slab. BCV was measured in through-transmission at 5 MHz. Impedance of the mineralized matrix (Z(m)) and porosity (Por) were obtained from 50 MHz scanning acoustic microscopy. Por and Z(m) had comparable effects on BCV along the bone axis (R=-0.57 and R=0.72, respectively).
authors.affiliation: UPMC Univ Paris 06, UMR 7623, Laboratoire d'Imagerie Paramétrique, F-75005 Paris, France. grdjulien@gmail.com
authors.forename: Julien
authors.initials: J
authors.lastname: Grondin
authors.forename: Quentin
authors.initials: Q
authors.lastname: Grimal
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Mami
authors.initials: M
authors.lastname: Matsukawa
authors.forename: Amena
authors.initials: A
authors.lastname: Saïed
authors.forename: Pascal
authors.initials: P
authors.lastname: Laugier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004548:Elasticity; D004867:Equipment Design; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D066298:In Vitro Techniques; D016014:Linear Models; D033401:Microscopy, Acoustic / Q000295:instrumentation*; D016062:Porosity