title: Increased brain temperature in Parkinson's disease.
abstract: The maintenance of a stable temperature is of the utmost importance for the proper functioning of the brain. Brain temperature is tightly linked to mitochondrial energetics. Although Parkinson's disease is characterized by mitochondrial dysfunction, no data are available on brain temperature. We measured the temperature in the visual cortex and in the centrum semiovale at rest by proton magnetic resonance spectroscopy in patients with Parkinson's disease and in age-matched and sex-matched control participants. We report evidence of increased temperature in the visual cortex and, to a minor extent, in the centrum semiovale of patients with Parkinson's disease. The increase in brain temperature is best explained by an energy loss along the oxidative phosphorylation/respiratory chain.
authors.affiliation: Department of Neurological Sciences, Parkinson's Disease Center, IRCCS Ca' Granda-Ospedale Maggiore Policlinico Foundation, University of Milan, Via F. Sforza 35, Milan, Italy. mariocristia@yahoo.it
authors.forename: Mario
authors.initials: M
authors.lastname: Rango
authors.forename: Andrea
authors.initials: A
authors.lastname: Arighi
authors.forename: Cristiana
authors.initials: C
authors.lastname: Bonifati
authors.forename: Nereo
authors.initials: N
authors.lastname: Bresolin
mesh_terms: D000368:Aged; D001831:Body Temperature / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010300:Parkinson Disease / Q000378:metabolism* / Q000503:physiopathology