title: [Preparation of rat model of systemic inflammatory response syndrome induced by zymosan].
abstract: To establish a model of systemic inflammatory response syndrome (SIRS) in rats.
  
  
  
  SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.
  
  
  
  The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.
  
  
  
  The rat model of systemic inflammatory response syndrome has been successfully induced.
authors.affiliation: Department of Clinical Medicine, Zhejiang University City College, Hangzhou 310015, Zhejiang, China.
authors.forename: Qi-yu
authors.initials: QY
authors.lastname: Lu
authors.forename: Yu-yang
authors.initials: YY
authors.lastname: Zhou
authors.forename: Jun-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Meng
authors.forename: Jia-kan
authors.initials: JK
authors.lastname: Weng
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Shen
authors.initials: S
authors.lastname: Quan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010232:Paraffin / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014781:Viscera / Q000473:pathology; D015054:Zymosan / Q000633:toxicity*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D010232:Paraffin; D015054:Zymosan