title: Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models.
abstract: The purpose of this study was to investigate the effect of astaxanthin extracted from Paracoccus carotinifaciens on gastric mucosal damage in murine gastric ulcer models. Mice were pretreated with astaxanthin for 1 h before ulcer induction. Gastric ulcers were induced in mice by oral administration of hydrochloride (HCl)/ethanol or acidified aspirin. The effect of astaxanthin on lipid peroxidation in murine stomach homogenates was also evaluated by measuring the level of thiobarbituric acid reactive substance (TBARS). The free radical scavenging activities of astaxanthin were also measured by electron spin resonance (ESR) measurements. Astaxanthin significantly decreased the extent of HCl/ethanol- and acidified aspirin-induced gastric ulcers. Astaxanthin also decreased the level of TBARS. The ESR measurement showed that astaxanthin had radical scavenging activities against the 1,1-diphenyl-2-picrylhydrazyl radical and the superoxide anion radical. These results suggest that astaxanthin has antioxidant properties and exerts a protective effect against ulcer formation in murine models.
authors.affiliation: Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Murata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Oyagi
authors.forename: Dai
authors.initials: D
authors.lastname: Takahira
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuruma
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Shimazawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
mesh_terms: D000143:Acids / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects; D001713:Biphenyl Compounds / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D010230:Paracoccus / Q000737:chemistry*; D010851:Picrates / Q000378:metabolism; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D024341:Xanthophylls / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000143:Acids; D000897:Anti-Ulcer Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; D024341:Xanthophylls; D000431:Ethanol; C005948:astaxanthine; C004931:1,1-diphenyl-2-picrylhydrazyl; D001241:Aspirin