title: Ultrasound-assisted aza-Michael reaction in water: a green procedure.
abstract: The conjugate addition of amines to conjugated alkenes (commonly known as aza-Michael reaction) constitutes a key step for the synthesis of various complex natural products, antibiotics, α-amino alcohols and chiral auxiliaries. Ultrasound-induced addition of several amines to α, β-unsaturated ketones, esters and nitriles has been carried out very efficiently in water as well as under solvent-free conditions. No catalysts or solid supports have been used in this method. Remarkable enhancement of reaction rate has been observed in water under ultrasound-induced method. This environmentally benign procedure has provided clean formation of the products with better selectivity.
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78539, USA.
authors.forename: Debasish
authors.initials: D
authors.lastname: Bandyopadhyay
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Luis C
authors.initials: LC
authors.lastname: Turrubiartes
authors.forename: Bimal K
authors.initials: BK
authors.lastname: Banik
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D055772:Green Chemistry Technology / Q000379:methods*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013010:Sonication; D014867:Water / Q000737:chemistry*
chemical_list: D000588:Amines; D004952:Esters; D007659:Ketones; D009570:Nitriles; D012997:Solvents; D014867:Water