title: Assessment of the developmental and reproductive toxicity of diiodomethyl-p-tolylsulfone in rats and rabbits.
abstract: Diiodomethyl-p-tolylsulfone (DIMPTS) was tested in developmental toxicity (DT) and reproductive toxicity studies. In the rat DT study, DIMPTS was administered at 0, 100, 300 or 1000 mg/kg/day. Maternal toxicity as evidenced by reductions in body weight gain or feed consumption at 1000 and, to a lesser extent, 300 mg/kg/day. The only developmental effect was umbilical hernia at 1000 mg/kg/day; therefore, NOELs for maternal and developmental toxicity were 100 and 300 mg/kg/day, respectively. In the rabbit DT study, NZW rabbits were gavaged with 0, 0.05, 0.5 and 2mg/kg/day DIMPTS. The NOEL for maternal toxicity was 0.5mg/kg/day, based on thyroid weight increase with histopathology. There were no observed developmental effects. In the two-generation study, CD rats were fed 0, 2.5, 10 or 40 mg/kg/day DIMPTS. Increased thyroid weight and histopathology were observed at all doses with associated pituitary findings in males. Reproductive toxicity at 40 mg/kg/day consisted of increased postimplantation loss, decreased gestation survival and two cases of dystocia, while litter size, pup survival/weight were affected at 10 and 40 mg/kg/day. The NOEL for parental toxicity could not be determined, while the NOEL for reproductive toxicity was 2.5mg/kg/day. The maternal thyroid and reproductive effects in this study were consistent with iodine toxicity.
authors.affiliation: Toxicology & Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA. clzablotny@dow.com
authors.forename: Carol L
authors.initials: CL
authors.lastname: Zablotny
authors.forename: Reza J
authors.initials: RJ
authors.lastname: Rasoulpour
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Pitt
authors.forename: Edward W
authors.initials: EW
authors.lastname: Carney
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001555:Benzene Derivatives / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D047109:Fetal Development / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D013450:Sulfones / Q000633:toxicity*; D013961:Thyroid Gland / Q000187:drug effects / Q000254:growth & development / Q000473:pathology
chemical_list: D001555:Benzene Derivatives; D013450:Sulfones; C076281:1-(diiodomethyl)sulfonyl-4-methyl benzene