title: Two selective fluorescent chemosensors for cadmium ions in 99% aqueous solution: the end group effect on the selectivity, DFT calculations and biological applications.
abstract: Two fluorescent chemosensors for cadmium ions, 2-(2-formylquinolin-8-yloxy)-N,N-diisopropylacetamide (FQDIPA) and 2-(2-formylquinolin-8-yloxy)-N,N-diphenylacetamide (FQDPA), were first assessed in 99% aqueous solutions. The sensor FQDIPA with an end group of an aliphatic amine can recognize Cd(2+) from other metal ions more selectively and sensitively than FQDPA with that of aromatic amines, which was further demonstrated by DFT calculations that were comparable to the experimental results. It is indeed the distinction between the end groups of these chemosensors that results in the variation of the energy difference between the LUMOs and HOMOs and the interaction energies of FQDIPA·Cd(2+) and FQDPA·Cd(2+). Furthermore, the living cell image experiment could also indicate that the FQDIPA is more suitable than the FQDPA in the practical applications in biological systems.
authors.affiliation: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Tian
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Junling
authors.initials: J
authors.lastname: Zhu
authors.forename: Haiping
authors.initials: H
authors.lastname: Wang
authors.forename: Yiran
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Sun
authors.forename: Weisheng
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Huang
authors.forename: Xuhuan
authors.initials: X
authors.lastname: Yan
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yao
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000042:Absorption; D002104:Cadmium / Q000032:analysis* / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D011789:Quantum Theory; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D012996:Solutions; D002104:Cadmium; D014867:Water