title: Plasmodium falciparum malaria in children at a tertiary teaching hospital: ABO blood group is a risk factor.
abstract: BACKGROUND
  ABO blood group antigens are formed by terminal glycosylation of glycoproteins and glycolipid chains present on cell surfaces. Glycosylation modulates all kinds of cell-to-cell interactions and this may be relevant in malaria pathophysiology, in which adhesion has been increasingly implicated in disease severity. This study was done to determine the association between ABO phenotypes and the severity of P. falciparum malaria in children.
  
  
  METHODS
  One hundred and twenty one children were assessed at the Department of Child Health, KBTH from May to August 2008. ABO blood groups were determined by agglutination. The haemoglobin measurement was done with the haematology analyzer, Sysmex KX-21N. Malaria parasites were enumerated and the presence of malaria pigment noted. Identification of P. falciparum was done. Statistical tests used were odds ratio and chi square at a significance level of p<0.05.
  
  
  RESULTS
  24.3% of the 121 children had severe falciparum malaria, and their mean haemoglobin was 4.49 g/dl (SD ± 1.69). No significant association was found between the ABO phenotypes and malaria infection (p > 0.05). Blood group A was associated with more severe malaria as compared to the blood group O individuals (Odds ratio = 0.79, p > 0.05); blood group AB (Odds ratio = 0.14, p > 0.05) and also there was a significant difference in severity of malaria between blood group O and blood group B (Odds ratio = 1.28, p > 0.05).
  
  
  CONCLUSIONS
  Non-O blood group children are more prone to severe malaria caused by P. falciparum malaria than the group O, despite the lack of significant association between ABO blood groups and falciparum malaria.
authors.affiliation: Department of Medical Laboratory Sciences, School of Allied Health Sciences, Korle-Bu, Accra, Ghana.
authors.forename: John Teye
authors.initials: JT
authors.lastname: Kuadzi
authors.forename: George
authors.initials: G
authors.lastname: Ankra-Badu
authors.forename: Mark Michael
authors.initials: MM
authors.lastname: Addae
mesh_terms: D000017:ABO Blood-Group System; D002675:Child, Preschool; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000276:immunology*; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D000017:ABO Blood-Group System