title: Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI.
abstract: OBJECTIVE
  The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence.
  
  
  CONCLUSIONS
  Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.
authors.affiliation: Section of Neuroradiology, Department of Radiation Oncology, New York University School of Medicine, NYU Langone Medical Center, 550 First Ave, New York, NY 10016, USA. girish.fatterpekar@nyumc.org
authors.forename: Girish M
authors.initials: GM
authors.lastname: Fatterpekar
authors.forename: Diogo
authors.initials: D
authors.lastname: Galheigo
authors.forename: Ashwatha
authors.initials: A
authors.lastname: Narayana
authors.forename: Glyn
authors.initials: G
authors.lastname: Johnson
authors.forename: Edmond
authors.initials: E
authors.lastname: Knopp
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D003287:Contrast Media; D003937:Diagnosis, Differential; D018450:Disease Progression; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009336:Necrosis / Q000175:diagnosis / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011832:Radiation Injuries / Q000175:diagnosis*
chemical_list: D003287:Contrast Media