title: Structure, assembly and reading of centromeric chromatin.
abstract: Centromeres are epigenetically defined chromatin domains marked by the presence of the histone H3 variant CENP-A. Here we review recent structural and biochemical work on CENP-A, and advances in understanding the mechanisms that propagate and read centromeric chromatin domains.
authors.affiliation: Institute for Research in Immunology and Cancer, Dept of Pathology and Cell Biology, Université de Montréal, Montréal, QC H3C 3J7, Canada. paul.maddox@umontreal.ca
authors.forename: Paul S
authors.initials: PS
authors.lastname: Maddox
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Corbett
authors.forename: Arshad
authors.initials: A
authors.lastname: Desai
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000737:chemistry* / Q000378:metabolism*; D002503:Centromere; D000076247:Centromere Protein A; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding
chemical_list: D001324:Autoantigens; C000619700:CENPA protein, human; D000076247:Centromere Protein A; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone