title: Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles.
abstract: A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P.R. China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Luo
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Cai
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Jinghua
authors.initials: J
authors.lastname: Li
authors.forename: Xingwei
authors.initials: X
authors.lastname: Ding
authors.forename: Beilu
authors.initials: B
authors.lastname: Zhang
authors.forename: Dawei
authors.initials: D
authors.lastname: Xu
authors.forename: Weihu
authors.initials: W
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism*; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D042541:Intracellular Space / Q000378:metabolism*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011094:Polyethyleneimine / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D047392:beta-Cyclodextrins; D004317:Doxorubicin; D011094:Polyethyleneimine; C031215:betadex