title: A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes.
abstract: A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H(2)O (8:1:1) affords peptide aldehydes in high yield and purity.
authors.affiliation: Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210008, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Kang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhi
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xu
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000447:Aldehydes; D010080:Oxazoles; D010455:Peptides; C064210:oxazolidine