title: Analysis of Tie2-expressing monocytes (TEM) in patients with colorectal cancer.
abstract: Tie2-expressing monocytes (TEM) promote tumor angiogenesis and growth in experimental cancer models. The role of TEM in cancer patients is unknown. We studied TEM in healthy volunteers and colorectal cancer (CRC) patients. Although TEM were detectable in the blood and tumor lesions of CRC patients, their frequency and functional phenotype showed no correlation with levels of angiopoietin-2 or vascular endothelial growth factor, microvessel density, tumor markers, tumor stage, or outcome of antiangiogenic therapy. These unexpected findings are at odds with murine tumor models and question the diagnostic or therapeutic value of TEM in human cancer.
authors.affiliation: Department of Internal Medicine I, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, Cologne, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Goede
authors.forename: Oliver
authors.initials: O
authors.lastname: Coutelle
authors.forename: Alexander
authors.initials: A
authors.lastname: Shimabukuro-Vornhagen
authors.forename: Udo
authors.initials: U
authors.lastname: Holtick
authors.forename: Janina
authors.initials: J
authors.lastname: Neuneier
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Koslowsky
authors.forename: Martin R
authors.initials: MR
authors.lastname: Weihrauch
authors.forename: Michael
authors.initials: M
authors.lastname: von Bergwelt-Baildon
authors.forename: Ulrich T
authors.initials: UT
authors.lastname: Hacker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000098:blood supply; D005260:Female; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000737:chemistry*; D042787:Receptor, TIE-2 / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D018950:Lipopolysaccharide Receptors; D042461:Vascular Endothelial Growth Factor A; D042787:Receptor, TIE-2