title: Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
abstract: The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM. All patients were assessed for the severity of illness at baseline and at discharge by means of the Positive and Negative Symptoms Scale (PANSS). Our findings suggest the lack of influence of SNPs under investigation in the present study on the susceptibility to SKZ and on the response to antipsychotics. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
authors.affiliation: Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Crisafulli
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiesa
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Lee
authors.forename: Dong Suk
authors.initials: DS
authors.lastname: Shim
authors.forename: Beatrice
authors.initials: B
authors.lastname: Balzarro
authors.forename: Costanza
authors.initials: C
authors.lastname: Andrisano
authors.forename: Antonina
authors.initials: A
authors.lastname: Sidoti
authors.forename: Ashwin A
authors.initials: AA
authors.lastname: Patkar
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D050882:CREB-Binding Protein / Q000235:genetics*; D016009:Chi-Square Distribution; D051786:Cyclic AMP Response Element Modulator / Q000235:genetics*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; C115163:CREB1 protein, human; C497410:CREM protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D051786:Cyclic AMP Response Element Modulator; D050882:CREB-Binding Protein; C494363:CREBBP protein, human