title: Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence.
abstract: An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.
authors.affiliation: Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Anass
authors.initials: A
authors.lastname: Znabet
authors.forename: Sara
authors.initials: S
authors.lastname: Blanken
authors.forename: Elwin
authors.initials: E
authors.lastname: Janssen
authors.forename: Frans J J
authors.initials: FJ
authors.lastname: de Kanter
authors.forename: Madeleine
authors.initials: M
authors.lastname: Helliwell
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D008958:Models, Molecular; D011392:Proline / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines; D011392:Proline