title: Cyto-mechanoresponsive polyelectrolyte multilayer films.
abstract: Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.
authors.affiliation: Centre National de la Recherche Scientifique, Institut Charles Sadron, UPR 22, 67034 Strasbourg Cedex, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Davila
authors.forename: Armelle
authors.initials: A
authors.lastname: Chassepot
authors.forename: Johan
authors.initials: J
authors.lastname: Longo
authors.forename: Fouzia
authors.initials: F
authors.lastname: Boulmedais
authors.forename: Andreas
authors.initials: A
authors.lastname: Reisch
authors.forename: Benoît
authors.initials: B
authors.lastname: Frisch
authors.forename: Florent
authors.initials: F
authors.lastname: Meyer
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Voegel
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: Mésini
authors.forename: Bernard
authors.initials: B
authors.lastname: Senger
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Metz-Boutigue
authors.forename: Joseph
authors.initials: J
authors.lastname: Hemmerlé
authors.forename: Philippe
authors.initials: P
authors.lastname: Lavalle
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.forename: Loïc
authors.initials: L
authors.lastname: Jierry
mesh_terms: D032701:Biomimetics; D002448:Cell Adhesion; D004573:Electrolytes / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology; D040542:Mechanotransduction, Cellular; D009842:Oligopeptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004573:Electrolytes; D009842:Oligopeptides; D011108:Polymers; C047981:arginyl-glycyl-aspartic acid