title: Palladium-mediated cell-surface labeling.
abstract: Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of  Escherichia coli ; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Spicer
authors.forename: Therese
authors.initials: T
authors.lastname: Triemer
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004926:Escherichia coli / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D001897:Boronic Acids; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D010165:Palladium