title: Who put the "A" in Atg12: autophagy or apoptosis?
abstract: Much deliberation surrounds how the two homeostatic pathways, autophagy and apoptosis, converge; in the December 9 issue of Molecular Cell, Rubinstein et al. (2011) identify a proapoptotic role for the autophagic protein Atg12, based on a BH3-like domain, which enables binding and inhibition of antiapoptotic Bcl-2 family proteins.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Triona
authors.initials: T
authors.lastname: Ni Chonghaile
authors.forename: Anthony
authors.initials: A
authors.lastname: Letai