title: [Clinical analysis of 6 cases of primary small cell carcinoma of the larynx].
abstract: OBJECTIVE
  To study the clinical characteristics, pathological features, diagnosis, therapy and prognosis of primary small cell carcinoma of the larynx (PSCCL).
  
  
  METHODS
  Six cases of PSCCL collected from 1990 to 2009 was retrospectively analyzed. The diagnosis was confirmed by pathological examination. Among six patients, one case belonged to stage III, and the others were in stage IVA. One case abandoned treatment; one case received chemotherapy; one case underwent supraglottic hemilaryngectomy and adjuvant chemoradiotherapy; one case underwent induction chemotherapy, radiotherapy and consolidation chemotherapy. Two cases received induction chemotherapy, concurrent chemoradiation and consolidation chemotherapy. The drug regimens included bleomycin, fluorouracil, cisplatin, etoposide and taxel for 3-6 cycles. The radiotherapy technique included conventional radiotherapy, CT-Sim and three dimensional conformal radiation therapy with (60)Co or 4 MV X-ray for 60 - 66 Gy during 6 - 7 weeks.
  
  
  RESULTS
  The time of follow-up was 3 - 24 months and the median was 13 months. Two patients applied with concurrent chemoradiation were alive without tumor. The patient abandoning therapy died of respiratory failure, and the others died of lung or liver metastasis after 8 - 12 months.
  
  
  CONCLUSIONS
  PSCCL is a disseminated disease, so the pretreatment evaluation is necessary. Concurrent chemoradiation is an ideal treatment model for this disease.
authors.affiliation: Oncology Center, People's Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Yuan-hong
authors.initials: YH
authors.lastname: Gao
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Ge
authors.initials: G
authors.lastname: Wen
authors.forename: Le-hui
authors.initials: LH
authors.lastname: Du
authors.forename: Feng-jun
authors.initials: FJ
authors.lastname: Cao
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Jing
authors.forename: Meng-zhong
authors.initials: MZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult