title: Brain metastases from epithelial ovarian carcinoma: evaluation of prognosis and managements - a Taiwanese Gynecologic Oncology Group (TGOG) study.
abstract: OBJECTIVE
  To evaluate the characteristics and outcome of patients with brain metastases from epithelial ovarian carcinoma.
  
  
  METHODS
  The clinical and pathologic characteristics, treatment and outcome of patients with brain metastases from epithelial ovarian carcinoma were analyzed from eight medical centers in Taiwan under the TGOG (Taiwanese Gynecologic Oncology Group).
  
  
  RESULTS
  A total of 64 patients were recruited in this study. The incidence of brain metastases from epithelial ovarian carcinoma seemed to be increasing in recent years. The median survival from the diagnosis of brain metastases was 8 months (range: 0-72). Prior cancer relapse before the diagnosis of brain metastases, number of brain metastases and multimodal treatment were related to the duration of survival.
  
  
  CONCLUSIONS
  The prognosis for patients with brain metastases from epithelial ovarian carcinoma is generally poor. However, clinicians should keep alert to the neurological complaints of ovarian cancer patients and the patients might benefit from aggressive multimodal treatments.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ying-Cheng
authors.initials: YC
authors.lastname: Chiang
authors.forename: Jian-Tai
authors.initials: JT
authors.lastname: Qiu
authors.forename: Chih-Long
authors.initials: CL
authors.lastname: Chang
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Wang
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Ho
authors.forename: Wu-Chou
authors.initials: WC
authors.lastname: Lin
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Huang
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
authors.forename: Chien-Hsing
authors.initials: CH
authors.lastname: Lu
authors.forename: Cheng-Yang
authors.initials: CY
authors.lastname: Chou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy; D000077216:Carcinoma, Ovarian Epithelial; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome