title: Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits.
abstract: The purpose of the present study was to investigate the lipid lowering effect of Cinnamomum zeylanicum (Cinnamon) in hyperlipidaemic albino rabbits. For this purpose, forty eight albino rabbits were randomly divided into eight equal groups; untreated control on normal routine feed, untreated control on butter and cholesterol, treated control on synthetic cholesterol lowering drug simvastatin (Tablet survive (R) 20 mg), three treated groups on three respective doses of C. zeylanicum bark powder and two treated groups on water and methanol extracts of C. zeylanicum bark powder. Butter ad lib and cholesterol powder 500 mg/kg body weight were used to induce experimental hyperlipidaemia in all groups except untreated control group. The results suggested that C. zeylanicum bark powder at the rate of 0.50 g/kg, 0.75 g/kg and methanol extract equivalent to 0.75 g/kg powder produced respective percent reductions in total lipids by 45, 49 and 64; triglycerides by 38, 53 and 60; total cholesterol by 53, 64 and 69 and LDL-cholesterol by 50, 59 and 62. However, at these dosage levels HDL-cholesterol showed respective percent increase of 42, 48 and 53. Nonetheless, C. zeylanicum bark powder at the level of 0.25g/kg and C. zeylanicum extract in water could not significantly reduce lipid profile indicators. Based on these studies, it can safely be said that C. zeylanicum bark powder methanol extract equivalent to 0.75g/kg bark powder and simvastatin (0.6 mg/kg b. wt.) were equieffective in treating hyperlipidaemia.
authors.affiliation: Department of Physiology and Pharmacology, University of Agriculture Faisalabad, Pakistan.
authors.forename: Ijaz
authors.initials: I
authors.lastname: Javed
authors.forename: Imran
authors.initials: I
authors.lastname: Faisal
authors.forename: Ziaur
authors.initials: Z
authors.lastname: Rahman
authors.forename: Muhammad Zargham
authors.initials: MZ
authors.lastname: Khan
authors.forename: Faqir
authors.initials: F
authors.lastname: Muhammad
authors.forename: Bilal
authors.initials: B
authors.lastname: Aslam
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
authors.forename: Andleeb
authors.initials: A
authors.lastname: Shahzadi
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D002935:Cinnamomum zeylanicum; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008517:Phytotherapy / Q000379:methods*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use*; D011208:Powders / Q000627:therapeutic use*; D011817:Rabbits; D019821:Simvastatin / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D010936:Plant Extracts; D011208:Powders; D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin