title: Early prediction of the response of breast tumors to neoadjuvant chemotherapy using quantitative MRI and machine learning.
abstract: The ability to predict early in the course of treatment the response of breast tumors to neoadjuvant chemotherapy can stratify patients based on response for patient-specific treatment strategies. Currently response to neoadjuvant chemotherapy is evaluated based on physical exam or breast imaging (mammogram, ultrasound or conventional breast MRI). There is a poor correlation among these measurements and with the actual tumor size when measured by the pathologist during definitive surgery. We tested the feasibility of using quantitative MRI as a tool for early prediction of tumor response. Between 2007 and 2010 twenty consecutive patients diagnosed with Stage II/III breast cancer and receiving neoadjuvant chemotherapy were enrolled on a prospective imaging study. Our study showed that quantitative MRI parameters along with routine clinical measures can predict responders from non-responders to neoadjuvant chemotherapy. The best predictive model had an accuracy of 0.9, a positive predictive value of 0.91 and an AUC of 0.96.
authors.affiliation: Vanderbilt University, Nashville, TN, USA.
authors.forename: Subramani
authors.initials: S
authors.lastname: Mani
authors.forename: Yukun
authors.initials: Y
authors.lastname: Chen
authors.forename: Lori R
authors.initials: LR
authors.lastname: Arlinghaus
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: A Bapsi
authors.initials: AB
authors.lastname: Chakravarthy
authors.forename: Sandeep R
authors.initials: SR
authors.lastname: Bhave
authors.forename: E Brian
authors.initials: EB
authors.lastname: Welch
authors.forename: Mia A
authors.initials: MA
authors.lastname: Levy
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Yankeelov
mesh_terms: D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis