title: Repairing the chronic damaged kidney: the role of regenerative medicine.
abstract: The increasing number of patients who suffer from chronic kidney diseases combined with the organ shortage have directed the attention of researchers to new alternatives in the fields of regenerative medicine including cell-based therapies and tissue bioengineering. This review of renal regenerative medicine addresses the mechanisms of action by stem cells to regenerate or repair chronically damaged renal tissue, alternative routes for their delivery, the role of biomaterials in tissue engineering, and the potential therapeutic effects of combining cell therapy with biomaterials. Despite the promise of ongoing work for therapy of chronic renal failure, caution is required as a large gap still exists between scientific knowledge and clinical translation for safe, effective stem cell-based therapies.
authors.affiliation: Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil.
authors.forename: H C
authors.initials: HC
authors.lastname: Caldas
authors.forename: A P C
authors.initials: AP
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Abbud-Filho
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D014019:Tissue Donors / Q000600:supply & distribution; D023822:Tissue Engineering; D016896:Treatment Outcome