title: Recent trends of Japanese hepatocellular carcinoma due to HCV in aging society.
abstract: OBJECTIVE
  The mean age of hepatocellular carcinoma (HCC) patients has increased (=65 years old). We want to identify the recent trend of the clinical features of HCC patients due to hepatitis C virus (HCV) (HCV-HCC).
  
  
  METHODS
  From 2000 to 2009, 855 naive HCC patients were admitted. HCV-HCC patients were divided into two groups, first period group (2000-04, n=270) and second period group (2005-09, n=343) and the clinical features of HCV-HCC were investigated.
  
  
  RESULTS
  There was no difference in gender, TNM stage and percentages of HCV-HCC between the periods. On the other hand, the ratio of HCV-HCC patients with worse liver function (Child-Pugh B or C), elderly (=75 years old) and the population of patients treated with low invasive radiofrequency ablation were increased (30.0% to 42.0%, 17.2% to 35.8% and 25.1% to 36.2%, respectively; p<0.01). The 1y-, 3y- and 5y-survival rate of HCV-HCC did not show differences (82.1%, 60.5% and 44.7% vs. 81.8%, 56.9% and 37.7%, respectively; p=0.219).
  
  
  CONCLUSIONS
  The ratio of aged HCV-HCC as well as HCV-HCC patients with worse liver function was increased. The less invasive treatment for HCC in these patients and the quick anti-viral treatment for HCV patients should be considered to avoid occurrence of HCC in Japan.
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan. hirage@m.ehime-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraoka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hidaka
authors.forename: Yukou
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Hiroki
authors.initials: H
authors.lastname: Utsunomiya
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Haruka
authors.initials: H
authors.lastname: Tatsukawa
authors.forename: Nayu
authors.initials: N
authors.lastname: Tazuya
authors.forename: Hiroka
authors.initials: H
authors.lastname: Yamago
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Yorimitsu
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanihira
authors.forename: Aki
authors.initials: A
authors.lastname: Hasebe
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirooka
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D000998:Antiviral Agents / Q000627:therapeutic use; D044466:Asian People / Q000706:statistics & numerical data; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000473:pathology / Q000628:therapy / Q000821:virology*; D016009:Chi-Square Distribution; D018450:Disease Progression; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000208:ethnology / Q000473:pathology / Q000628:therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D000998:Antiviral Agents