title: Histologic and histomorphometric evaluation of a synthetic bone substitute for maxillary sinus grafting in humans.
abstract: OBJECTIVE
  The present study investigated the efficacy of a biphasic calcium phosphate as a bone grafting material for maxillary sinus augmentation in humans.
  
  
  METHODS
  Half of the thirty patients selected for sinus augmentation were grafted with biphasic calcium phosphate, whereas the other half were grafted with autogenous bone chips harvested intraorally. After 9 months of healing, bone cores were retrieved from implant sites for histologic and histomorphometric evaluation.
  
  
  RESULTS
  The areas augmented with autogenous bone chips showed newly formed bone with a pattern very similar to that of the native area. Histomorphometry demonstrated that the amount of newly formed bone in the autogenous bone group was significantly greater than in the biphasic calcium phosphate group (P < 0.05). In the biphasic calcium phosphate group, less bone formation was observed in the area further away from native bone interface than in the area closer to native bone interface (P < 0.05), whereas no significant differences were observed between both areas in the autogenous group. In both groups, the implant survival rate was 100% with a minimum 1-year follow-up.
  
  
  CONCLUSIONS
  The data presented in this work confirm the osteoconductive properties of biphasic calcium phosphate, as well as its use in association with maxillary sinus floor augmentation procedures with successful outcomes.
authors.affiliation: Department of Oral Implantology, Institute of Health Research CETAO, São Paulo, Brazil. maurotosta@me.com
authors.forename: Mauro
authors.initials: M
authors.lastname: Tosta
authors.forename: Arthur R G
authors.initials: AR
authors.lastname: Cortes
authors.forename: Luciana
authors.initials: L
authors.lastname: Corrêa
authors.forename: Décio Dos S
authors.initials: Ddos S
authors.lastname: Pinto
authors.forename: Isabel
authors.initials: I
authors.lastname: Tumenas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Katchburian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064592:Autografts; D001706:Biopsy / Q000379:methods; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D003094:Collagen; D003758:Dental Implantation, Endosseous / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008443:Maxillary Sinus / Q000473:pathology; D008567:Membranes, Artificial; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: C106416:Bio-Gide; D018786:Bone Substitutes; D006882:Hydroxyapatites; D008567:Membranes, Artificial; C074950:hydroxyapatite-beta tricalcium phosphate; D003094:Collagen