title: Developmental origins of cerebrovascular disease II: considering gene-environment interactions when developing neuroprotective strategies.
abstract: The second part of this review of the developmental origins of cerebrovascular disease discusses prenatal gene-environment interactions concerning maternal, placental, and fetal conditions that culminate in specific injuries such as perinatal stroke, as well as complications of intrauterine growth restriction and congenital heart disease. A greater understanding of gene-environment influences on cerebrovascular health and disease in early life will contribute to the successful development of neuroprotective strategies throughout the lifespan.
authors.affiliation: School of Medicine, Case Western Reserve University, and Division of Pediatric Neurology, Fetal/Neonatal Neurology Program, Rainbow Babies and Children's Hospital, Case Medical Center, University Hospitals of Cleveland, OH, USA. Mark.scher@uhhospitals.org
authors.forename: Mark S
authors.initials: MS
authors.lastname: Scher
mesh_terms: D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000235:genetics; D059647:Gene-Environment Interaction; D006801:Humans; D007231:Infant, Newborn; D020521:Stroke / Q000209:etiology* / Q000235:genetics