title: A case of complete hydatidiform mole in a perimenopausal woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 fluorescent in situ hybridization.
abstract: Gestational trophoblastic disease in perimenopausal women is very rare. A 53-year-old perimenopausal woman complained about amenorrhea lasting over a period of 4months. Ultrasound showed enlargement of the uterus with a complex echogeneous area in the uterine cavity. Serum human chorionic gonadotropin was 67,611mIU/ml. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The uterus contained hemorrhagic and fragile tumor with grape-like vesicles in the enlarged endometrial cavity. Microscopic examination revealed hydropically degenerated villi with circumferential hyperplasia of atypical trophoblast and cistern formation. p57(kip2) immnostaining was negative in villous cytotrophoblasts and stromal cells. Moreover, fluorescent in situ hybridization for HER2 was scored as diploid. These findings are consistent with complete hydatidiform mole. The diagnosis of hydatidiform mole must be considered in perimenopausal women, and the combination of p57(kip2) immunostaining and HER2 fluorescent in situ hybridization seems to be a very useful testing strategy for difficult situations regarding the differential diagnosis of completed and partial hydatidiform mole.
authors.affiliation: Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.forename: Mariko
authors.initials: M
authors.lastname: Fujibayashi
authors.forename: Shinpei
authors.initials: S
authors.lastname: Hori
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Umekita
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D050761:Cyclin-Dependent Kinase Inhibitor p57 / Q000032:analysis*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D006965:Hyperplasia; D007044:Hysterectomy; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D010052:Ovariectomy; D047648:Perimenopause; D011237:Predictive Value of Tests; D011247:Pregnancy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D058994:Salpingectomy; D014594:Uterine Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D050761:Cyclin-Dependent Kinase Inhibitor p57; D018719:Erb-b2 Receptor Tyrosine Kinases; C493964:CDKN1C protein, human; C508053:ERBB2 protein, human