title: Novel production method of porous surface Ti samples for biomedical application.
abstract: A porous implant material with adequate pore structure and the appropriate mechanical properties for bone ingrowth has long been sought. This article presents details of the development, characterization and in vivo evaluations of powder metallurgy-processed titanium samples exhibiting a dense core with an integrated porous surface for biomedical applications. A space-holder method was applied to investigate the effects of different percentages and particle sizes of the urea on bone neoformation in 30 rabbits. The samples were previously characterized using scanning electron microscopy and mechanical testing. After 8 and 12 weeks of implantation, bone ingrowth was histologically and histometrically analyzed and push-out testing was performed. This study demonstrated that the association of a dense core integrated with the greatest number of interconnected pores of the smallest size is a promising biomaterial for bone tissue engineering. This sample exhibits appropriate mechanical properties combined with increased bone ingrowth, providing enhanced resistance to displacement.
authors.affiliation: Department of Bioscience and Oral Diagnosis, São Jose dos Campos School of Dentistry, Universidade Estadual Paulista (UNESP), São José dos Campos, SP, Brazil. luanamrv@gmail.com
authors.forename: Luana Marotta Reis
authors.initials: LM
authors.lastname: de Vasconcellos
authors.forename: Fernanda Nascimento
authors.initials: FN
authors.lastname: Oliveira
authors.forename: Daniel de Oliveira
authors.initials: Dde O
authors.lastname: Leite
authors.forename: Luis Gustavo Oliveira
authors.initials: LG
authors.lastname: de Vasconcellos
authors.forename: Renata Falchete
authors.initials: RF
authors.lastname: do Prado
authors.forename: Carolina Judica
authors.initials: CJ
authors.lastname: Ramos
authors.forename: Mário Lima de Alencastro
authors.initials: ML
authors.lastname: Graça
authors.forename: Carlos Alberto Alves
authors.initials: CA
authors.lastname: Cairo
authors.forename: Yasmin Rodarte
authors.initials: YR
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001842:Bone and Bones / Q000378:metabolism; D020099:Coated Materials, Biocompatible; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning / Q000379:methods; D015233:Models, Statistical; D016348:Osseointegration; D010316:Particle Size; D016062:Porosity; D011208:Powders / Q000737:chemistry; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011208:Powders; D014025:Titanium