title: Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.
abstract: Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens.
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
authors.forename: Jeong-su
authors.initials: JS
authors.lastname: Do
authors.forename: Gilles
authors.initials: G
authors.lastname: Foucras
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kamada
authors.forename: Austin F
authors.initials: AF
authors.lastname: Schenk
authors.forename: Michael
authors.initials: M
authors.lastname: Shaw
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nuñez
authors.forename: William E
authors.initials: WE
authors.lastname: Paul
authors.forename: Booki
authors.initials: B
authors.lastname: Min
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D049109:Cell Proliferation / Q000187:drug effects; D000068876:Fingolimod Hydrochloride; D006706:Homeostasis / Q000187:drug effects / Q000276:immunology; D007156:Immunologic Memory / Q000187:drug effects / Q000276:immunology; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008231:Lymphopenia / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011409:Propylene Glycols / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D001324:Autoantigens; D011409:Propylene Glycols; D011948:Receptors, Antigen, T-Cell; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine