title: A metabolic network of a phosphate-accumulating organism provides new insights into enhanced biological phosphorous removal.
abstract: Here we present a metabolic network representing the central carbon metabolism as well as the synthesis of polyhydroxyalcanohates and the polyphosphate accumulation mechanisms of the bacterium Candidatus Accumulibacter phosphatis, which was previously identified from metagenomic studies in enhanced biological phosphorous removal sludges. The reconstructed metabolic network, together with flux balance analysis can be used to provide new insights into controversial aspects of the metabolism of phosphate-accumulating organisms and is also a tool that can be used in to help enhanced biological phosphorous removal (EBPR) process design and operation.
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden. velasco@chalmers.se
authors.forename: Sergio
authors.initials: S
authors.lastname: Bordel
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D020562:Betaproteobacteria / Q000378:metabolism*; D004734:Energy Metabolism; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*; D010758:Phosphorus / Q000737:chemistry / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D010710:Phosphates; D014874:Water Pollutants, Chemical; D010758:Phosphorus