title: [Changes of thymocyte differentiation, proliferation and apoptosis induced by syntetic peptides].
abstract: The changes in the processes of differentiation, proliferation and apoptosis were studied in the culture of human cortical thymocytes after cell exposure to T-32 and T-38 bioregulator peptides. T-32 and T-38 peptides were shown to enhance the differentiation of immature cortical thymocytes (CD4+CD8+) into T-regulatory cells by increasing their proliferate activity and decreasing the level of apoptosis. Moreover, these peptides were found to stimulate the proliferative and antiapoptotic activity of mature T-regulatory (CD4+CD25+) cells.
authors.forename: A A
authors.initials: AA
authors.lastname: Iarilin
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: V O
authors.initials: VO
authors.lastname: Poliakova
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoĭ
mesh_terms: D017209:Apoptosis / Q000187:drug effects* / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects* / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D060168:Thymocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D009842:Oligopeptides; C533570:lysyl-glutamyl-aspartic acid