title: Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.
abstract: The pathogenesis of Alzheimer's disease (AD) is tightly associated with metabolic dysfunctions. In particular, a potential link between type 2 diabetes (T2DM) and AD has been suggested epidemiologically, clinically, and experimentally, and some studies have suggested that exercise or dietary intervention reduces risk of cognitive decline. However, there is little solid molecular evidence for the effective intervention of metabolic dysfunctions for prevention of AD. In the present study, we established the AD model mice with diabetic conditions through high-fat diet (HFD) to examine the effect of environmental enrichment (EE) on HFD-induced AD pathophysiology. Here, we demonstrated that HFD markedly deteriorated memory impairment and increased β-amyloid (Aβ) oligomers as well as Aβ deposition in amyloid precursor protein (APP) transgenic mice, which was reversed by exposure to an enriched environment for 10 weeks, despite the continuation of HFD. These studies provide solid evidence that EE is a useful intervention to ameliorate behavioral changes and AD pathology in HFD-induced aggravation of AD symptoms in APP transgenic mice.
authors.affiliation: School of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Maesako
authors.forename: Kengo
authors.initials: K
authors.lastname: Uemura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kubota
authors.forename: Akira
authors.initials: A
authors.lastname: Kuzuya
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sasaki
authors.forename: Megumi
authors.initials: M
authors.lastname: Asada
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Watanabe
authors.forename: Naoko
authors.initials: N
authors.lastname: Hayashida
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ihara
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Ito
authors.forename: Shun
authors.initials: S
authors.lastname: Shimohama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kihara
authors.forename: Ayae
authors.initials: A
authors.lastname: Kinoshita
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D004041:Dietary Fats / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004195:Disease Models, Animal; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control*; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D016229:Amyloid beta-Peptides; D004041:Dietary Fats