title: Co-ordination of cough and swallow in vivo and in silico.
abstract: Coughing and swallowing are airway-protective behaviours. The pharyngeal phase of swallowing prevents aspiration of oral material (saliva, food and liquid) by epiglottal movement, laryngeal adduction and clearing of the mouth and pharynx. Coughing is an aspiration-response behaviour that removes material from the airway. Co-ordination of these behaviours is vital to protect the airway from further aspiration-promoting events, such as a swallowing during the inspiratory phase of coughing. The operational characteristics, primary strategies and peripheral inputs that co-ordinate coughing and swallowing are unknown. This lack of knowledge impedes understanding and treatment of deficits in airway protection, such as the co-occurrence of dystussia and dysphagia common in Parkinson's and Alzheimer's diseases, as well as stroke.
authors.affiliation: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA. tepitts@ufl.edu
authors.forename: Teresa
authors.initials: T
authors.lastname: Pitts
authors.forename: Kendall
authors.initials: K
authors.lastname: Morris
authors.forename: Bruce
authors.initials: B
authors.lastname: Lindsey
authors.forename: Paul
authors.initials: P
authors.lastname: Davenport
authors.forename: Ivan
authors.initials: I
authors.lastname: Poliacek
authors.forename: Donald
authors.initials: D
authors.lastname: Bolser
mesh_terms: D000818:Animals; D003371:Cough / Q000503:physiopathology*; D003679:Deglutition / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology