title: A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: the effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats.
abstract: We developed a novel thermoelectric cooling device using Peltier modules for the treatment of spinal cord injury in rats. The extracorporeal electrically cooling component was attached to the aluminum arched plate which was placed on the surface of the spinal cord after the contusion injury in the 11th thoracic spinal cord. During the hypothermic treatment, rats were awake and could move in the cage. Hind limb motor function, evaluated using a BBB scale, in the hypothermic animals (33°C for 48 h) was significantly higher than that in the normothermic animals from 2 weeks to 8 weeks after the injury.
authors.affiliation: Spine Center, Ehime University Hospital, Tohon-city, Ehime 791-0295, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Morizane
authors.forename: Tadanori
authors.initials: T
authors.lastname: Ogata
authors.forename: Tadao
authors.initials: T
authors.lastname: Morino
authors.forename: Hideki
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Gotaro
authors.initials: G
authors.lastname: Yamaoka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Miura
mesh_terms: D000818:Animals; D005260:Female; D007036:Hypothermia, Induced / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*