title: Usefulness of serum neopterin levels in acute decompensated heart failure to predict renal dysfunction.
abstract: BACKGROUND
  Neopterin serum concentration increases in the presence of renal dysfunction.
  
  
  OBJECTIVE
  We sought to determine the relationship between admission serum neopterin levels and worsening renal function (WRF) in patients with heart failure (HF).
  
  
  METHODS
  We prospectively measured serum neopterin levels in patients with HF and the patients were subdivided into two groups: with and without WRF during hospital admission.
  
  
  RESULTS
  Logistic regression analysis showed that high serum neopterin levels at admission were associated with a greater likelihood of developing WRF.
  
  
  CONCLUSIONS
  Patients admitted to hospital with HF, elevated serum neopterin levels are associated with an increased risk of developing WRF.
authors.affiliation: Hospital Universitario de Canarias, Department of Cardiology, Tenerife, Spain. adrvdg@hotmail.com
authors.forename: Alberto
authors.initials: A
authors.lastname: Dominguez-Rodriguez
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-Gonzalez
authors.forename: Ruben A
authors.initials: RA
authors.lastname: Juarez-Prera
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arroyo-Ucar
authors.forename: Celestino
authors.initials: C
authors.lastname: Hernandez-Garcia
authors.forename: Maria Carrillo-Perez
authors.initials: MC
authors.lastname: Tome
authors.forename: Gabriela E
authors.initials: GE
authors.lastname: Blanco-Palacios
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Kaski
mesh_terms: D000368:Aged; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D019798:Neopterin / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D051437:Renal Insufficiency / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D019798:Neopterin