title: Effects of atorvastatin on heart mitochondrial function and coenzyme Q content in the experiment.
abstract: We focused on determination of whether atorvastatin: 1) reduces CoQ content, 2) impairs mitochondrial function and 3) induces dose-dependent changes. Although the high dose of atorvastatin exerted a beneficial effect on the lipid peroxidation in plasma, coenzyme Q content was reduced and heart mitochondrial function was impaired. Physicians should be aware when prescribing statins mainly in higher doses to the patients with co-existing proved or supposed CoQ10 deficiency resulting from age-related decline, and metabolic or mitochondrial diseases (Ref. 3).
authors.affiliation: Pharmacobiochemical Laboratory of Third Department of lnternal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia. jarmila.kucharska@fmed.uniba.sk
authors.forename: J
authors.initials: J
authors.lastname: Kucharska
authors.forename: O
authors.initials: O
authors.lastname: Ulicna
authors.forename: A
authors.initials: A
authors.lastname: Gvozdjakova
authors.forename: O
authors.initials: O
authors.lastname: Vancova
authors.forename: I
authors.initials: I
authors.lastname: Waczulikova
authors.forename: P
authors.initials: P
authors.lastname: Bozek
authors.forename: V
authors.initials: V
authors.lastname: Bada
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D006538:Heptanoic Acids / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014451:Ubiquinone; D000069059:Atorvastatin