title: Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus.
abstract: This study compares the effects of a single bout of exercise (acute extenuating) with those promoted by an exercise training program (chronic), focusing on low-grade chronic inflammation profile and on oxidative stress status, using the obese ZDF rats as a model of type 2 diabetes mellitus (T2DM). Animals were sacrificed after 12 weeks of a swimming training program and after a single bout of acute extenuating exercise. Glycaemic, insulinemic, and lipidic profile (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum CRPhs, TNF-α, adiponectin) and oxidative (lipidic peroxidation and uric acid) status. When compared to obese diabetic sedentary rats, the animals submitted to acute exercise presented significantly lower values of glycaemia and insulinaemia, with inflammatory profile and oxidative stress significantly aggravated. The trained animals showed amelioration of glycaemic and lipidic dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative markers. In conclusion, the results presented herein suggessted that exercise pathogenesis-oriented interventions should not exacerbate underlying inflammatory stress associated with T2DM.
authors.affiliation: Laboratory of Pharmacology & Experimental Therapeutics, Institute for Biomedical Research on Light and Image, Coimbra University, 3000-548 Coimbra, Portugal.
authors.forename: Edite
authors.initials: E
authors.lastname: Teixeira de Lemos
authors.forename: Rui
authors.initials: R
authors.lastname: Pinto
authors.forename: Jorge
authors.initials: J
authors.lastname: Oliveira
authors.forename: Patrícia
authors.initials: P
authors.lastname: Garrido
authors.forename: José
authors.initials: J
authors.lastname: Sereno
authors.forename: Filipa
authors.initials: F
authors.lastname: Mascarenhas-Melo
authors.forename: João
authors.initials: J
authors.lastname: Páscoa-Pinheiro
authors.forename: Frederico
authors.initials: F
authors.lastname: Teixeira
authors.forename: Flávio
authors.initials: F
authors.lastname: Reis
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004195:Disease Models, Animal; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D011897:Random Allocation; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014527:Uric Acid / Q000097:blood
chemical_list: D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014527:Uric Acid