title: Chiral calix[4]arenes bearing amino alcohol functionality as membrane carriers for transport of chiral amino acid methylesters and mandelic acid.
abstract: Novel chiral calix[4]arene derivatives bearing amino alcohol moieties at the lower rim have been synthesized from the reaction of p-tert-butylcalix[4]arene diester with various amino alcohols. The transport of amino acid esters (phenylglycine, phenylalanine, and tryptophan methyl esters hydrochloride) and mandelic acid were studied through chloroform bulk liquid membrane system using chiral calix[4]arenes 15-20. All these receptors have been found to act as carriers for transport of aromatic amino acid methylesters and mandelic acid from the aqueous source phase to the aqueous receiving phase. The influence of calixarene and guest structures upon transport through liquid membrane is discussed.
authors.affiliation: Department of Chemistry, Selçuk University, 42099 Konya, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Bozkurt
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Sirit
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D008333:Mandelic Acids / Q000737:chemistry* / Q000302:isolation & purification; D008566:Membranes / Q000737:chemistry*; D008738:Methyl Ethers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D004337:Drug Carriers; D008333:Mandelic Acids; D008738:Methyl Ethers; D047250:Calixarenes; C037938:mandelic acid