title: Stabilized vesicles consisting of small amphiphiles for stepwise photorelease via UV light.
abstract: A small amphiphile consisting of hydrophilic tetraethylene glycol monoacrylate and hydrophobic alkyl chain which were connected by an o-nitrobenzyl unit, a photolabile group, was designed and synthesized. The critical aggregate concentration of the synthesized amphiphile was determined to be about 3 × 10(-5) M by the fluorescence probe technique. Nanosized vesicles were prepared and stabilized by in-situ radical polymerization without altering the morphology. The polymeric vesicle was highly stable which retained vesicular shape under dilution or UV irradiation. Hydrophobic guests can be encapsulated within the vesicle membrane and released out of the vesicle by UV stimulus through splitting the amphiphilic structure of the amphiphile. Distinguished dose-controlled photorelease of the polymeric vesicle is achieved due to the maintenance of the vesicular shape integrity which makes the guest release depend on the cleavage amount of amphiphilic structure during UV irradiation. This study provides a promising strategy to develop stable drug delivery systems for sustained and phototriggered release.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Dong
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Xun
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Han
authors.forename: Jinping
authors.initials: J
authors.lastname: Chen
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
mesh_terms: D000179:Acrylates / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods; D010078:Oxazines / Q000737:chemistry; D010777:Photochemistry / Q000379:methods; D012542:Scattering, Radiation; D014466:Ultraviolet Rays
chemical_list: D000179:Acrylates; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D010078:Oxazines; C044808:nile red