title: EGFR as a predictor of relapse in myxopapillary ependymoma.
abstract: Myxopapillary ependymoma (MPE) is a rare subtype of ependymoma in children. Though classified as a Grade I tumor, their unpredictable behavior and propensity for local and disseminated recurrence poses a therapeutic challenge. Till date no predictive molecular markers exist for such recurrence, especially with dissemination. We demonstrated that Epidermal Growth Factor Receptor (EGFR) expression was seen in relapsed MPE both at diagnosis and at recurrence and none in the nonrecurring tumors. This finding suggests EGFR could be a predictive biomarker for recurrence in MPE.
authors.affiliation: Division of Pediatric Hematology/Oncology, Primary Children's Medical Center, Salt Lake City, Utah, USA.
authors.forename: Anupam
authors.initials: A
authors.lastname: Verma
authors.forename: Holly
authors.initials: H
authors.lastname: Zhou
authors.forename: Steve
authors.initials: S
authors.lastname: Chin
authors.forename: Carol
authors.initials: C
authors.lastname: Bruggers
authors.forename: John
authors.initials: J
authors.lastname: Kestle
authors.forename: Soumen
authors.initials: S
authors.lastname: Khatua
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004806:Ependymoma / Q000175:diagnosis* / Q000556:secondary; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011379:Prognosis; D000077022:Survivin; D044767:Ubiquitin-Protein Ligases / Q000032:analysis
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases; D066246:ErbB Receptors