title: Co-transplantation of macaque autologous Schwann cells and human embryonic nerve stem cells in treatment of macaque Parkinson's disease.
abstract: OBJECTIVE
  To investigate the therapeutic effects of co-transplantation with Schwann cells (SCs) and human embryonic nerve stem cells (NSCs) on macaque Parkinson's disease (PD).
  
  
  METHODS
  Macaque autologous SCs and human embryonic NSCs were adopted for the treatment of macaque PD.
  
  
  RESULTS
  Six months after transplantation, positron emission computerized tomography showed that (18)F-FP-β-CIT was significantly concentrated in the injured striatum in the co-transplanted group. Immunohistochemical staining of transplanted area tissue showed migration of tyroxine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.
  
  
  CONCLUSIONS
  Co-transplantation of SCs and NSCs could effectively cure PD in macaques. SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems, so it is expected to be applied clinically.
authors.affiliation: Department of Neurosurgery, Haikou Hospital, Xiangya Medical School, Central South University, Haikou, China. xiaying008@163.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.forename: Chengchuan
authors.initials: C
authors.lastname: Jiang
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Cao
authors.forename: Keshan
authors.initials: K
authors.lastname: Shi
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000378:metabolism; D020820:Dyskinesias / Q000503:physiopathology; D053595:Embryonic Stem Cells / Q000637:transplantation*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008251:Macaca; D008297:Male; D009043:Motor Activity; D064847:Multimodal Imaging; D009417:Nerve Tissue / Q000637:transplantation*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000378:metabolism; D012583:Schwann Cells / Q000637:transplantation*; D033581:Stem Cell Transplantation; D014057:Tomography, X-Ray Computed; D014326:Tropanes / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane