title: A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
abstract: We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery phase and follow-up of the top 61 SNPs in an additional 2,703 cases and 3,464 controls. We identified associations at 17p13 (rs3803800, P = 9.40 × 10(-11), OR = 1.21; rs4227, P = 4.31 × 10(-10), OR = 1.23) and 8p23 (rs2738048, P = 3.18 × 10(-14), OR = 0.79) that implicated the genes encoding tumor necrosis factor (TNFSF13) and α-defensin (DEFA) as susceptibility genes. In addition, we found multiple associations in the major histocompatibility complex (MHC) region (rs660895, P = 4.13 × 10(-20), OR = 1.34; rs1794275, P = 3.43 × 10(-13), OR = 1.30; rs2523946, P = 1.74 × 10(-11), OR = 1.21) and confirmed a previously reported association at 22q12 (rs12537, P = 1.17 × 10(-11), OR = 0.78). We also found that rs660895 was associated with clinical subtypes of IgAN (P = 0.003), proteinuria (P = 0.025) and IgA levels (P = 0.047). Our findings show that IgAN is associated with variants near genes involved in innate immunity and inflammation.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. yuxq@mail.sysu.edu.cn
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Hui-Qi
authors.initials: HQ
authors.lastname: Low
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Wang
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
authors.forename: Kar-Seng
authors.initials: KS
authors.lastname: Sim
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Jia-Nee
authors.initials: JN
authors.lastname: Foo
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Li
authors.forename: Xian-Yong
authors.initials: XY
authors.lastname: Yin
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Rong-Shan
authors.initials: RS
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Wan
authors.forename: Zhang-Suo
authors.initials: ZS
authors.lastname: Liu
authors.forename: Tan-Qi
authors.initials: TQ
authors.lastname: Lou
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Liu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011507:Proteinuria / Q000235:genetics; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics; D023084:alpha-Defensins / Q000235:genetics
chemical_list: D007070:Immunoglobulin A; C114631:TNFSF13 protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D023084:alpha-Defensins