title: Determinants of premature atherosclerosis in children with end-stage renal disease.
abstract: Cardiovascular disease is a major cause of morbidity and mortality in young adults with end-stage renal disease (ESRD), but its basis is still not well understood. We therefore evaluated the determinants of atherosclerosis in children with ESRD. A total of 37 children with ESRD (with 31 who had undergone transplantation) were examined and compared to a control group comprising 22 healthy children. The common carotid intima-media thickness (CIMT) was measured by ultrasound as a marker of preclinical atherosclerosis. The association of CIMT with anthropometrical data, blood pressure, plasma lipid levels, and other biochemical parameters potentially related to cardiovascular disease was evaluated. Children with ESRD had significantly higher CIMT, blood pressure, and levels of lipoprotein (a), urea, creatinine, ferritin, homocysteine, and serum uric acid as well as significantly lower values of apolipoprotein A. The atherogenic index of plasma (log(triglycerides/HDL cholesterol)) was also higher in patients with ESRD; however, this difference reached only borderline significance. In addition, a negative correlation was found between CIMT and serum albumin and bilirubin in the ESRD group, and this correlation was independent of age and body mass index. In the control group, a significant positive correlation was observed between CIMT and ferritin levels. Factors other than traditional cardiovascular properties, such as the anti-oxidative capacity of circulating blood, may be of importance during the early stages of atherosclerosis in children with end-stage renal disease.
authors.affiliation: Department of Neonatology, University Hospital Prague-Motol, Prague, Czech Republic. dvorakovahm@centrum.cz
authors.forename: H M
authors.initials: HM
authors.lastname: Dvořáková
authors.forename: P
authors.initials: P
authors.lastname: Szitányi
authors.forename: P
authors.initials: P
authors.lastname: Dvořák
authors.forename: J
authors.initials: J
authors.lastname: Janda
authors.forename: T
authors.initials: T
authors.lastname: Seeman
authors.forename: J
authors.initials: J
authors.lastname: Zieg
authors.forename: V
authors.initials: V
authors.lastname: Lánská
authors.forename: K
authors.initials: K
authors.lastname: Kotaška
authors.forename: J
authors.initials: J
authors.lastname: Piťha
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001663:Bilirubin / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D012709:Serum Albumin; D014280:Triglycerides; D001663:Bilirubin