title: Pharmacokinetic considerations for moderate and deep sedation.
abstract: Moderate and deep sedation can be provided using several routes of drug administration including oral (PO), inhalation, and parental injection. The safety and efficacy of these various techniques is largely dependent on pharmacokinetic principles. This continuing education article will highlight essential principles of absorption, distribution, and elimination of commonly used sedative agents.
authors.affiliation: Miami Valley Hospital, Dayton, OH, USA. debecker@mvh.org
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Becker
mesh_terms: D000042:Absorption; D000766:Anesthesia, Dental / Q000379:methods*; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D016292:Procedural Sedation; D054810:Deep Sedation; D004333:Drug Administration Routes; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D007262:Infusions, Intravenous; D014018:Tissue Distribution
chemical_list: D006993:Hypnotics and Sedatives