title: The unrealized potential of (34m)Cl for radiopharmaceutical research with PET.
abstract: The unstable isotopes of chlorine have a brief history limited largely to production from sulphur isotopes. Recent improvements in accelerator targetry have made radiochlorine available from small cyclotrons, and concurrent research into labeling chemistry suggests both electrophilic and nucleophilic avenues for the synthesis of novel imaging probes. The prevalence of chlorine compounds from anthropogenic and natural sources offers varied and fertile ground for future scientific explanation with their radiolabeled counterparts.
authors.affiliation: University of Wisconsin, Department of Medical Physics, USA. jwengle@wisc.edu
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Engle
authors.forename: Todd E
authors.initials: TE
authors.lastname: Barnhart
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Severin
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nickles
mesh_terms: D002626:Chemistry, Pharmaceutical; D002713:Chlorine; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes; D019275:Radiopharmaceuticals
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D002713:Chlorine