title: Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
abstract: The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.
authors.affiliation: Laboratório de Antibióticos, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil. thisosorio@bol.com.br
authors.forename: Thaís
authors.initials: T
authors.lastname: Moreira Osório
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Louise
authors.initials: L
authors.lastname: Domeneghini Chiaradia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mascarello
authors.forename: Taisa
authors.initials: T
authors.lastname: Regina Stumpf
authors.forename: Carlos
authors.initials: C
authors.lastname: Roberto Zanetti
authors.forename: Douglas
authors.initials: D
authors.lastname: Bardini Silveira
authors.forename: Célia
authors.initials: C
authors.lastname: Regina Monte Barardi
authors.forename: Elza
authors.initials: E
authors.lastname: de Fatima Albino Smânia
authors.forename: Aline
authors.initials: A
authors.lastname: Viancelli
authors.forename: Lucas
authors.initials: L
authors.lastname: Ariel Totaro Garcia
authors.forename: Rosendo
authors.initials: R
authors.lastname: Augusto Yunes
authors.forename: Ricardo
authors.initials: R
authors.lastname: José Nunes
authors.forename: Artur
authors.initials: A
authors.lastname: Smânia
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006801:Humans; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010069:Oxadiazoles / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000378:metabolism*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D047188:Chalcones; D006835:Hydrazones; D010069:Oxadiazoles; D008712:Methicillin