title: Long term follow-up of appendiceal and distal right-sided colonic inflammation.
abstract: The aim of this study was to investigate the possibility of appendiceal orifice inflammation (AOI) as a preceding lesion in the development of ulcerative colitis. A total of 20 patients were identified (mean age 41.2 years; 11 males) who had ulcerative colitis-like inflammatory lesions at the appendiceal orifice without concomitant typical features of ulcerative colitis, such as rectal involvement. A total of 19 patients were followed up endoscopically for a mean duration of 18.4 months (range 2 - 84 months). Typical ulcerative colitis developed in five patients (25 %; four proctitis, one pancolitis) in a mean time of 18.4 months (range 2 - 36 months). Negative conversion of all inflammatory lesions occurred in seven patients (35 %) after a mean follow-up of 20 months (range 3 - 84 months). In the remaining seven patients (35 %), initial lesions did not progress to ulcerative colitis and did not go into remission during a mean follow-up of 16.9 months (range 2 - 42 months). These results suggest that, at least in some cases, AOI precedes development of ulcerative colitis.
authors.affiliation: Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: S K
authors.initials: SK
authors.lastname: Yang
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
authors.forename: D H
authors.initials: DH
authors.lastname: Yang
authors.forename: K W
authors.initials: KW
authors.lastname: Jung
authors.forename: K J
authors.initials: KJ
authors.lastname: Kim
authors.forename: B D
authors.initials: BD
authors.lastname: Ye
authors.forename: J S
authors.initials: JS
authors.lastname: Byeon
authors.forename: S J
authors.initials: SJ
authors.lastname: Myung
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001064:Appendicitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003113:Colonoscopy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D012075:Remission, Spontaneous; D013997:Time Factors; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine