title: Scaling properties of conduction velocity in heterogeneous excitable media.
abstract: Waves of excitation through excitable media, such as cardiac tissue, can propagate as plane waves or break up to form reentrant spiral waves. In diseased hearts reentrant waves can be associated with fatal cardiac arrhythmias. In this paper we investigate the conditions that lead to wave break, reentry, and propagation failure in mathematical models of heterogeneous excitable media. Two types of heterogeneities are considered: sinks are regions in space in which the voltage is fixed at its rest value, and breaks are nonconducting regions with no-flux boundary conditions. We find that randomly distributed heterogeneities in the medium have a decremental effect on the velocity, and above a critical density of such heterogeneities the conduction fails. Using numerical and analytical methods we derive the general relationship among the conduction velocity, density of heterogeneities, diffusion coefficient, and the rise time of the excitation in both two and three dimensions. This work helps us understand the factors leading to reduced propagation velocity and the formation of spiral waves in heterogeneous excitable media.
authors.affiliation: Department of Physiology, McGill University, Montreal, Canada.
authors.forename: T K
authors.initials: TK
authors.lastname: Shajahan
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Borek
authors.forename: Alvin
authors.initials: A
authors.lastname: Shrier
authors.forename: Leon
authors.initials: L
authors.lastname: Glass