title: Neurotrophic effects of magnesium fructose 1, 6-diphosphate on cortical neurons.
abstract: In this study, we evaluated the neurotrophic effects of magnesium fructose 1, 6-diphosphate (FDP-Mg) on cortical neurons. The results demonstrated that FDP-Mg promoted dendrite outgrowth and neuronal survival in a dose-dependent manner. In order to investigate the associated mechanisms, we determined adenosine triphosphate (ATP) levels and brain-derived neurotrophic factor (BDNF) mRNA expression in cortical neurons. Treatment with FDP-Mg significantly increased ATP levels and BDNF mRNA expression in cortical neurons. These data suggest that FDP-Mg can exert neurotrophic effects on cortical neurons. The increases in BDNF mRNA expression and cellular ATP levels are involved in the neurotrophic effects produced by FDP-Mg.
authors.affiliation: Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632 China.
authors.forename: Lian-Feng
authors.initials: LF
authors.lastname: Lin
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xue
authors.forename: Min-Jing
authors.initials: MJ
authors.lastname: Liao
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Ruo-Hua
authors.initials: RH
authors.lastname: Lv
authors.forename: Huan-Min
authors.initials: HM
authors.lastname: Luo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002470:Cell Survival / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology*; D003712:Dendrites / Q000187:drug effects* / Q000502:physiology; D005635:Fructosediphosphates / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D005635:Fructosediphosphates; C489787:MAP2 protein, rat; D008869:Microtubule-Associated Proteins; D008274:Magnesium; C029063:fructose-1,6-diphosphate