title: Direct numerical simulation of a 2D-stented aortic heart valve at physiological flow rates.
abstract: We study the nonlinear interaction of an aortic heart valve, composed of hyperelastic corrugated leaflets of finite density attached to a stented vessel under physiological flow conditions. In our numerical simulations, we use a 2D idealised representation of this arrangement. Blood flow is caused by a time-varying pressure gradient that mimics that of the aortic valve and corresponds to a peak Reynolds number equal to 4050. Here, we fully account for the shear-thinning behaviour of the blood and large deformations and contact between the leaflets by solving the momentum and mass balances for blood and leaflets. The mixed finite element/Galerkin method along with linear discontinuous Lagrange multipliers for coupling the fluid and elastic domains is adopted. Moreover, a series of challenging numerical issues such as the finite length of the computational domain and the conditions that should be imposed on its inflow/outflow boundaries, the accurate time integration of the parabolic and hyperbolic momentum equations, the contact between the leaflets and the non-conforming mesh refinement in part of the domain are successfully resolved. Calculations for the velocity and the shear stress fields of the blood reveal that boundary layers appear on both sides of a leaflet. The one along the ventricular side transfers blood with high momentum from the core region of the vessel to the annulus or the sinusoidal expansion, causing the continuous development of flow instabilities. At peak systole, vortices are convected in the flow direction along the annulus of the vessel, whereas during the closure stage of the valve, an extremely large vortex develops in each half of the flow domain.
authors.affiliation: Department of Biomedical Engineering , Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
authors.forename: Y
authors.initials: Y
authors.lastname: Dimakopoulos
authors.forename: A C B
authors.initials: AC
authors.lastname: Bogaerds
authors.forename: P D
authors.initials: PD
authors.lastname: Anderson
authors.forename: M A
authors.initials: MA
authors.lastname: Hulsen
authors.forename: F P T
authors.initials: FP
authors.lastname: Baaijens
mesh_terms: D000465:Algorithms; D001021:Aortic Valve / Q000502:physiology* / Q000601:surgery; D001698:Biomedical Engineering; D003198:Computer Simulation; D020342:Finite Element Analysis; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D015607:Stents