title: Response to intra-arterial cisplatin and concurrent radiotherapy in a patient with primary mucosal malignant melanoma of the nasal cavity.
abstract: BACKGROUND
  The prognosis for patients with mucosal malignant melanoma (MMM) of the nasal cavity is very poor because of the radioresistance of melanoma cells.
  
  
  METHODS
  We present the first case report of the efficacy of superselective intra-arterial cisplatin (CDDP) infusion concurrent with hypofractionated radiotherapy (RT) for MMM of the nasal cavity.
  
  
  RESULTS
  A pink, polypoid mass, histopathologically diagnosed as an amelanostic melanoma, occupied the right nasal cavity. After the treatment, a nasal tumor disappeared, leaving only a small bulge in the medial wall of the middle turbinate. Histopathologic examination revealed scattered degenerated melanoma cells, remaining only in the small restricted area in the medial surface of the excised middle turbinate. Twelve months after the treatment, the patient has not experienced any local recurrence or regional and distant metastasis.
  
  
  CONCLUSIONS
  The superselective intra-arterial CDDP infusion concurrent with hypofractionated RT might be useful for the management of nasal MMM.
authors.affiliation: Department of Otolaryngology, University of Toyama, Toyama, Japan. hshojaku@med.u-toyama.ac.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Shojaku
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Takakura
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Tachino
authors.forename: Michiro
authors.initials: M
authors.lastname: Fujisaka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Gakuto
authors.initials: G
authors.lastname: Tomizawa
authors.forename: Hideto
authors.initials: H
authors.lastname: Kawabe
authors.forename: Hiroko
authors.initials: H
authors.lastname: Shojaku
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Miwa
authors.forename: Junya
authors.initials: J
authors.lastname: Fukuoka
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D009296:Nasal Cavity / Q000473:pathology; D009297:Nasal Mucosa / Q000473:pathology; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin