title: Description and plasmid characterization of qnrD determinants in Proteus mirabilis and Morganella morganii.
abstract: We investigated the presence of qnrC and qnrD among 756 non-replicate Enterobacteriaceae isolated in Italy, selected for being non-susceptible to fluoroquinolones and/or resistant to third-generation cephalosporins. Four Proteus mirabilis and one Morganella morganii (0.66% of the total) presented a qnrD gene, located in a 2687-base-pair plasmid that was entirely sequenced. The plasmid is un-typable, and contains no known coding region other than qnrD. That the qnrD gene was found in four unrelated P. mirabilis and in one M. morganii isolate might suggest a frequent association of this gene with the tribe Proteeae.
authors.affiliation: Department of Pathology and Diagnostics, University of Verona, Verona, Italy. annarita.mazzariol@univr.it
authors.forename: A
authors.initials: A
authors.lastname: Mazzariol
authors.forename: B
authors.initials: B
authors.lastname: Kocsis
authors.forename: R
authors.initials: R
authors.lastname: Koncan
authors.forename: E
authors.initials: E
authors.lastname: Kocsis
authors.forename: P
authors.initials: P
authors.lastname: Lanzafame
authors.forename: G
authors.initials: G
authors.lastname: Cornaglia
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D020613:Morganella morganii / Q000235:genetics* / Q000302:isolation & purification; D010957:Plasmids; D011513:Proteus mirabilis / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004269:DNA, Bacterial; D024841:Fluoroquinolones