title: Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector.
authors.affiliation: Department of Ophthalmology, Institute of Biophysics, CCS, UFRJ, Rio de Janeiro, 21941-902, Brazil. hilda.ufl@gmail.com
authors.forename: Hilda
authors.initials: H
authors.lastname: Petrs-Silva
authors.forename: Douglas
authors.initials: D
authors.lastname: Yasumura
authors.forename: Michael T
authors.initials: MT
authors.lastname: Matthes
authors.forename: Matthew M
authors.initials: MM
authors.lastname: LaVail
authors.forename: Alfred S
authors.initials: AS
authors.lastname: Lewin
authors.forename: William W
authors.initials: WW
authors.lastname: Hauswirth
mesh_terms: D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D004195:Disease Models, Animal; D004596:Electroretinography; D005799:Genes, Dominant / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D057809:HEK293 Cells; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D064531:Peripherins; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics* / Q000494:pharmacology; D012174:Retinitis Pigmentosa / Q000235:genetics* / Q000628:therapy*
chemical_list: D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C578997:PRPH2 protein, human; D064531:Peripherins; C578996:Prph2 protein, mouse; D012333:RNA, Messenger; D034741:RNA, Small Interfering