title: HIV-1, ubiquitin and ubiquitin-like proteins: the dialectic interactions of a virus with a sophisticated network of post-translational modifications.
abstract: The modification of intracellular proteins by ubiquitin (Ub) and ubiquitin-like (UbL) proteins is a central mechanism for regulating and fine-tuning all cellular processes. Indeed, these modifications are widely used to control the stability, activity and localisation of many key proteins and, therefore, they are instrumental in regulating cellular functions as diverse as protein degradation, cell signalling, vesicle trafficking and immune response. It is thus no surprise that pathogens in general, and viruses in particular, have developed multiple strategies to either counteract or exploit the complex mechanisms mediated by the Ub and UbL protein conjugation pathways. The aim of this review is to provide an overview on the intricate and conflicting relationships that intimately link HIV-1 and these sophisticated systems of post-translational modifications.
authors.affiliation: Centre d'étude d'agents Pathogènes et Biotechnologies pour la Santé (CPBS-CNRS), Montpellier Cedex 5, France. martine.biard@cpbs.cnrs.fr
authors.forename: Martine
authors.initials: M
authors.lastname: Biard-Piechaczyk
authors.forename: Sophie
authors.initials: S
authors.lastname: Borel
authors.forename: Lucile
authors.initials: L
authors.lastname: Espert
authors.forename: Geoffroy
authors.initials: G
authors.lastname: de Bettignies
authors.forename: Olivier
authors.initials: O
authors.lastname: Coux
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism / Q000821:virology; D003593:Cytoplasm / Q000378:metabolism; D015658:HIV Infections / Q000503:physiopathology*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D014452:Ubiquitins