title: [Pathophysiology of aging bone].
abstract: Deterioration of organ and systems function are the principal signs of aging. Aging is also believed to be a major factor in the loss of bone mass and quality, which in turn leads to an increase in the risk of fractures. Several factors seem to contribute to this scenario, with metabolic changes related to aging in the bone tissue itself being among them. Most of the current knowledge on the mechanisms associated with osteopenia/osteoporosis during aging has been generated from research in animal models (mainly rats and mice) and cell cultures derived from subjects of different ages. In this work, we have reviewed and summarised these studies, which have begun to establish the physiological and molecular basis of the bone alterations related to aging.
authors.affiliation: Laboratorio de Metabolismo Mineral y Óseo, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, España. sportal@fjd.es
authors.forename: Sergio
authors.initials: S
authors.lastname: Portal-Núñez
authors.forename: Daniel
authors.initials: D
authors.lastname: Lozano
authors.forename: Mónica
authors.initials: M
authors.lastname: de la Fuente
authors.forename: Pedro
authors.initials: P
authors.lastname: Esbrit
mesh_terms: D000375:Aging; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000378:metabolism; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D018384:Oxidative Stress