title: A biomimetic approach to lanthionines.
abstract: The asymmetric sulfa-Michael additions of appropriately protected L- and D-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin.
authors.affiliation: Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, U.A.-C.S.I.C., E-26006 Logroño, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Aydillo
authors.forename: Alberto
authors.initials: A
authors.lastname: Avenoza
authors.forename: Jesús H
authors.initials: JH
authors.lastname: Busto
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Jiménez-Osés
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Peregrina
authors.forename: María M
authors.initials: MM
authors.lastname: Zurbano
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000596:Amino Acids / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D013440:Sulfides; C001520:lanthionine; D000409:Alanine