title: Neurogenesis in a young dog with epileptic seizures.
abstract: Epileptic seizures can lead to various reactions in the brain, ranging from neuronal necrosis and glial cell activation to focal structural disorganization. Furthermore, increased hippocampal neurogenesis has been documented in rodent models of acute convulsions. This is a report of hippocampal neurogenesis in a dog with spontaneous epileptic seizures. A 16-week-old epileptic German Shepherd Dog had marked neuronal cell proliferation (up to 5 mitotic figures per high-power field and increased immunohistochemical expression of proliferative cell nuclear antigen) in the dentate gyrus accompanied by microglial and astroglial activation. Some granule cells expressed doublecortin, a marker of immature neurons; mitotically active cells expressed neuronal nuclear antigen. No mitotic figures were found in the brain of age-matched control dogs. Whether increased neurogenesis represents a general reaction pattern of young epileptic dogs should be investigated.
authors.affiliation: Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Frankfurter Str. 96, 35392 Giessen, Germany. christina.m.borschensky@vetmed.uni-giessen.de
authors.forename: C M
authors.initials: CM
authors.lastname: Borschensky
authors.forename: J S
authors.initials: JS
authors.lastname: Woolley
authors.forename: A
authors.initials: A
authors.lastname: Kipar
authors.forename: C
authors.initials: C
authors.lastname: Herden
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001344:Autopsy / Q000662:veterinary; D016022:Case-Control Studies; D002454:Cell Differentiation; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000473:pathology*; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D007150:Immunohistochemistry / Q000662:veterinary; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology; D010634:Phenobarbital / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital