title: Prevalence of coronary artery spasm during dobutamine stress echocardiography.
abstract: The aim of this study was to assess the prevalence of coronary artery spasm during dobutamine stress echocardiography (DSE). Over a 9-year period (from November 2001 to October 2010) we reviewed all patients (n = 2,224) referred for DSE. Criteria for selection included patients > 18 years old who underwent DSE. We systematically analyzed all electrocardiograms obtained during DSE to detect ST-segment elevation during the examination. All patients with ST-segment elevation underwent coronary angiography. DSE was performed in 2,179 patients. ST-segment elevation was observed in 21 patients, all of whom underwent emergency coronary angiography. In 13 of these 21 patients (62%) significant coronary stenosis was observed: 6 patients with critical coronary stenosis and 7 patients with chronic coronary occlusion. The remaining 8 patients (38% of patients presenting with ST-segment elevation during DSE, 7 men, mean age 67 ± 11 years) had no significant coronary stenosis. Prevalence of coronary artery spasm during DSE was 0.4%. In conclusion, physicians should be aware that, although rare, coronary artery spasm may occur during DSE.
authors.affiliation: Department of Cardiology, Pôle V Thorax Vasculaire Digestif Métabolisme, Centre de Référence pour les Maladies Cardiaques Héréditaires, Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne, France. nicolas.mansencal@apr.aphp.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mansencal
authors.forename: Imane
authors.initials: I
authors.lastname: El Hajjaji
authors.forename: Rami
authors.initials: R
authors.lastname: El Mahmoud
authors.forename: Franck
authors.initials: F
authors.lastname: Digne
authors.forename: Olivier
authors.initials: O
authors.lastname: Dubourg
mesh_terms: D000368:Aged; D002316:Cardiotonic Agents; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003329:Coronary Vasospasm / Q000453:epidemiology* / Q000209:etiology; D003331:Coronary Vessels / Q000503:physiopathology*; D004280:Dobutamine; D025401:Echocardiography, Stress / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine