title: Combination of biological and morphological parameters for the selection of patients with hepatocellular carcinoma waiting for liver transplantation.
abstract: BACKGROUND
  In the last several years, there has been no agreement on how to possibly expand the Milan criteria (MC) in the selection of patients with hepatocellular carcinoma (HCC) for listing for liver transplant (LT). The aim of the study is to evaluate morphological and biological tumor parameters to identify new expanded criteria for the selection of patients with HCC as candidates for LT.
  
  
  METHODS
  We retrospectively analyzed 158 consecutive patients with HCC who underwent LT.
  
  
  RESULTS
  Twelve (7.6%) recurrences were observed. At multivariate analysis, alpha-fetoprotein (AFP) >400 ng/mL (odds ratio [OR] 8.4, p<0.01) and total tumor diameter (TTD) >8 cm (OR 7.4, p=0.01) were the strongest predictors for recurrence. AFP-TTD criteria resulted in a low five-yr recurrence rate (4.9%) and an increased number of LT compared with the MC (22.2% increase). The five-yr disease-free survival rate was 74.4% in AFP-TTD criteria in patients, with a higher effectiveness in stratifying the cohort with respect to the MC.
  
  
  CONCLUSIONS
  Both AFP and TTD are good independent predictors of HCC recurrence. Their combination appears to obtain a better selection of candidates for LT without worsening patient survival and recurrence rates. This approach allows for an increase in the number of potentially transplantable patients.
authors.affiliation: Department of General Surgery and Organ Transplantation, Umberto I Hospital, Sapienza University, Rome, Italy. lai.quirino@libero.it
authors.forename: Quirino
authors.initials: Q
authors.lastname: Lai
authors.forename: Alfonso W
authors.initials: AW
authors.lastname: Avolio
authors.forename: Tommaso M
authors.initials: TM
authors.lastname: Manzia
authors.forename: Roberto
authors.initials: R
authors.lastname: Sorge
authors.forename: Salvatore
authors.initials: S
authors.lastname: Agnes
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tisone
authors.forename: Pasquale B
authors.initials: PB
authors.lastname: Berloco
authors.forename: Massimo
authors.initials: M
authors.lastname: Rossi
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D014850:Waiting Lists; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins