title: Immune correlates of herpes zoster in HIV-infected children and youth.
abstract: To identify immunologic factors that modulate the risk of herpes zoster (HZ), we compared varicella-zoster virus (VZV)-specific and nonspecific T-cell subpopulations of 47 HIV-infected children before they developed HZ with those of 141 VZV-positive HZ-negative matched controls. Compared with controls, HZ cases had lower VZV-specific CD8(+) CD107a(+) cell percentages independently of CD4(+) percentages or HIV loads, suggesting that VZV-specific cytotoxic T cells are protective against HZ. In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ.
authors.affiliation: University of Colorado Denver, Aurora, Colorado, USA. adriana.weinberg@ucdenver.edu
authors.forename: Adriana
authors.initials: A
authors.lastname: Weinberg
authors.forename: Sharon
authors.initials: S
authors.lastname: Huang
authors.forename: Lin-Ye
authors.initials: LY
authors.lastname: Song
authors.forename: Terry
authors.initials: T
authors.lastname: Fenton
authors.forename: Paige
authors.initials: P
authors.lastname: Williams
authors.forename: Julie
authors.initials: J
authors.lastname: Patterson
authors.forename: Adriana
authors.initials: A
authors.lastname: Tovar-Salazar
authors.forename: Myron J
authors.initials: MJ
authors.lastname: Levin
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D006562:Herpes Zoster / Q000209:etiology / Q000276:immunology* / Q000821:virology; D014645:Herpesvirus 3, Human / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000821:virology; D055815:Young Adult