title: [Pregnancy outcomes before and after the onset of rheumatoid arthritis].
abstract: OBJECTIVE
  to compare the obstetric prognosis before and after the onset of rheumatoid arthritis (RA).
  
  
  METHODS
  a survey in RA women patients who become sexually active before disease onset, and who tried or got pregnant after diagnosis was performed. Obstetrical features such as: number of pregnancies, threat of abortion, abortion, early natal death, congenital abnormalities and preeclampsia-eclampsia syndrome, before and after RA onset were compared.
  
  
  RESULTS
  only 47 women were eligible (age: 40.5 ± 11.0 years; time of evolution: 15.9 ± 11.5 years; positive rheumatoid factor: 93.6 %) from 700 screened. After RA onset there were 63 gestations in 36 patients who got pregnant (secondary infertility rate: 21.3 %). A significant increase in frequency and number of cesarean deliveries, besides a higher number of pregnancies with preeclampsia, were found after RA onset. Additionally, four newborns with congenital anomalies were reported after the disease onset compared to none before RA onset.
  
  
  CONCLUSIONS
  compared to pre-RA obstetric events, a higher frequency and number of adverse outcomes was found in pregnancies that occurred after RA onset.
authors.affiliation: Unidad Médica de Alta Especialidad 25, Instituto Mexicano del Seguro Social, Mérida, Yucatán, México. nemegyei@yahoo.com.mx
authors.forename: José
authors.initials: J
authors.lastname: Alvarez-Nemegyei
authors.forename: María Teresa de Jesús
authors.initials: MT
authors.lastname: Cervantes-Díaz
authors.forename: Francisco
authors.initials: F
authors.lastname: Avila-Zapata
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Marín-Ordóñez
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011446:Prospective Studies