title: Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis.
abstract: OBJECTIVE
  The present study was designed to investigate whether titres of antibody to two strains of Porphyromonas gingivalis, FDC381 and SU63, are associated with serum high-sensitivity C-reactive protein (hs-CRP) levels in Japanese periodontitis patients.
  
  
  METHODS
  Forty-nine patients with moderate to advanced periodontitis and 40 periodontally healthy control subjects were included in this study. hs-CRP levels and antibody titres to P. gingivalis were measured at baseline and reassessment 3-4 months after periodontal treatment in periodontitis patients as well as at the time of examination in the periodontally healthy subjects. Further, the effect of periodontal therapy, including surgical treatment and use of antibacterials on both markers, was analysed in patients.
  
  
  RESULTS
  hs-CRP levels and antibody titres to P. gingivalis were higher in periodontitis patients than in control subjects, and they significantly decreased following periodontal treatment (p < 0.005). Also, a significant decrease in hs-CRP levels as a result of periodontal treatment was found in patients with hs-CRP levels >1 mgl(-1) at baseline (p < 0.005). Probing depth, clinical attachment level, and alveolar bone loss in patients were significantly associated with a higher antibody titre to both strains of P. gingivalis (p < 0.05), but were not related to hs-CRP levels. No relationship was observed between hs-CRP levels and tertiles as defined by titres of antibody to P. gingivalis strains FDC381 and SU63.
  
  
  CONCLUSIONS
  Our data indicate that hs-CRP levels were independent of antibody titres to P. gingivalis in Japanese periodontitis patients.
authors.affiliation: Center for Transdisciplinary Research, Niigata University, Niigata 9518514, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Miyashita
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Honda
authors.forename: Tomoki
authors.initials: T
authors.lastname: Maekawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Yukari
authors.initials: Y
authors.lastname: Aoki
authors.forename: Takako
authors.initials: T
authors.lastname: Nakajima
authors.forename: Koichi
authors.initials: K
authors.lastname: Tabeta
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000704:Analysis of Variance; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000276:immunology* / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D012044:Regression Analysis; D018709:Statistics, Nonparametric
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D002097:C-Reactive Protein