title: [Prevention of postoperative hyperalgesia].
abstract: Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia. Different drugs, most of which are NMDA receptors antagonists, are used to decrease or prevent the risk of central or opiate-induced hyperalgesia. However, it is difficult to determine whether they are really effective and at which dosage: the results of most published studies are difficult to interpret because of methodological problems. The two most frequent of those are: absence of objective measurement of secondary hyperalgesia and difficulties targeting an at risk population.
authors.affiliation: Unité d'anesthésie pédiatrique, division d'anesthésiologie, hôpitaux universitaires de Genève, Suisse. chantal.mamie@hcuge.ch
authors.forename: C
authors.initials: C
authors.lastname: Mamie
mesh_terms: D000547:Amantadine / Q000627:therapeutic use; D000588:Amines / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D007649:Ketamine / Q000627:therapeutic use; D017616:Magnesium Compounds / Q000627:therapeutic use; D059408:Pain Management / Q000379:methods; D010149:Postoperative Pain / Q000139:chemically induced / Q000517:prevention & control*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D018570:Risk Assessment; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000588:Amines; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D017616:Magnesium Compounds; D016194:Receptors, N-Methyl-D-Aspartate; D005680:gamma-Aminobutyric Acid; D007649:Ketamine; D000077206:Gabapentin; D000547:Amantadine