title: Cord blood analysis for rapid prenatal confirmation of Hb Bart's disease using the Sebia Capillary electrophoresis system.
abstract: Prenatal diagnosis of severe α-thalassemia (α-thal) diseases is usually performed by DNA analysis. To establish a simple and rapid method, we evaluated the reliability of cord blood hemoglobin (Hb) analysis using an automated capillary electrophoresis (CE) system. Our results demonstrated that analysis of fetal Hb using the Sebia CapillaryS 2 is an effective, accurate and simple alternative for prenatal diagnosis of Hb Bart's (γ4) disease.
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Can
authors.initials: C
authors.lastname: Liao
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhou
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Xie
authors.forename: Ru
authors.initials: R
authors.lastname: Li
authors.forename: Dong-Zhi
authors.initials: DZ
authors.lastname: Li
mesh_terms: D000328:Adult; D017218:Cordocentesis; D019075:Electrophoresis, Capillary; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005319:Fetal Hemoglobin / Q000032:analysis; D005838:Genotype; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics*; D011296:Prenatal Diagnosis; D017085:alpha-Thalassemia / Q000175:diagnosis / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal; D005319:Fetal Hemoglobin; C030448:hemoglobin Bart's