title: [Fertility after prostate brachytherapy with Iode 125 permanent implants for localized prostate cancer].
abstract: OBJECTIVE
  Preservation of fertility in men of middle age is an issue that is experiencing a growing interest. Prostate cancer is the second most common cancer in men and is diagnosed earlier than before. Brachytherapy is a treatment for prostate cancer that preserves ejaculation. Our aim was to study the fertility of men treated with prostate brachytherapy in order to improve patient information.
  
  
  METHODS
  In a series of 270 sexually active men with localized prostate cancer treated with brachytherapy (permanent implants of Iode 125) at the Institute Claudius Regaud between 2000 and 2006, mean age 65 years (43-80), four patients spontaneously expressed their interest in the preservation of fertility and had an andrological evaluation.
  
  
  RESULTS
  Four patients were aged 43, 48, 57 and 61 years, all working (including two businessmen), their partner was aged respectively 42, 37, 47 and 38 years. All four had a post-treatment semen analysis (done over a year after brachytherapy) rich in spermatozoa, with moderate asthenospermia, the main anomaly being severe hypospermia. These spermiograms were nonetheless consistent with the occurrence of spontaneous pregnancy (occurrence of miscarriage in the patient 1).
  
  
  CONCLUSIONS
  There is an interest in applying to men with prostate cancer their position on fertility in order to inform them about the morbidity of various treatments, options for fertility preservation, and the need to continue a contraception after brachytherapy if the partner is not menopausal.
authors.affiliation: Département d'urologie et d'andrologie, CHU Rangueil, 1, avenue J.-Poulhes, TSA 50032, 31059 Toulouse cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Delaunay
authors.forename: M
authors.initials: M
authors.lastname: Delannes
authors.forename: J-M
authors.initials: JM
authors.lastname: Bachaud
authors.forename: M
authors.initials: M
authors.lastname: Bouaziz
authors.forename: A
authors.initials: A
authors.lastname: Salloum
authors.forename: M
authors.initials: M
authors.lastname: Thoulouzan
authors.forename: M
authors.initials: M
authors.lastname: Soulié
authors.forename: P
authors.initials: P
authors.lastname: Plante
authors.forename: E
authors.initials: E
authors.lastname: Huyghe
mesh_terms: D000328:Adult; D001918:Brachytherapy; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D012661:Semen / Q000166:cytology; D013094:Spermatozoa / Q000166:cytology
chemical_list: D007457:Iodine Radioisotopes