title: Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-ones.
abstract: Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-ones, was developed using chiral phosphoric acid as catalyst and a Hantzsch ester as the hydrogen source with up to 95% ee. The reaction process of this asymmetric transfer hydrogenation may occur directly through the acyliminium ion intermediate.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China.
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Qing-An
authors.initials: QA
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Duan
authors.forename: Zhi-Shi
authors.initials: ZS
authors.lastname: Ye
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D006865:Hydrogenation; D054833:Isoindoles / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D054833:Isoindoles; D010756:Phosphoric Acids; D006859:Hydrogen; C030242:phosphoric acid