title: Nutrient detection by incretin hormone secreting cells.
abstract: The hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulintropic polypeptide (GIP) are secreted after a meal. Like other enteroendocrine hormones they help to orchestrate the bodies' response to the availability of newly absorbable nutrients and are noteworthy as they stimulate postprandial insulin secretion, underlying what is known as the incretin effect. GLP-1-mimetics are now widely used in the treatment of type 2 diabetes and advantages over older insulinotropic therapies include weight loss. An alternative treatment regime might be the recruitment of endogenous GLP-1, however, very little is known about the physiological control of enteroendocrine responses. This review focuses on the molecular mechanisms to detect nutrient arrival in the gut that have been implicated within the incretin secreting cells.
authors.affiliation: Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Diakogiannaki
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Gribble
authors.forename: Frank
authors.initials: F
authors.lastname: Reimann
mesh_terms: D000818:Animals; D055098:Endocrine Cells / Q000378:metabolism*; D005502:Food; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000166:cytology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans
chemical_list: D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1