title: Efficacy of locally-delivered doxycycline microspheres in chronic localized periodontitis and on Porphyromonas gingivalis.
abstract: OBJECTIVE
  This study aimed to assess the efficacy and effect of locally-delivered doxycycline microspheres with scaling and root planing in periodontal pocket therapy and on Porphyromonas gingivalis, respectively.
  
  
  METHODS
  Twenty sites with a probing pocket depth of 4-6 mm were divided into two groups: a control group consisting of scaling and root planing, with one application of doxycycline microspheres only at baseline, and a test group consisting of scaling and root planing, with an application of doxycycline microspheres at baseline and 1 and 3 months. Clinical readings included the plaque index, gingival index, probing pocket depth, and relative attachment level. Rapid polymerase chain reaction method was used for the detection of P. gingivalis.
  
  
  RESULTS
  A statistically-significant reduction in probing pocket depth and attachment gain was found in both groups; the test group showed a significant reduction in probing pocket depth and attachment gain compared with the control at 3 and 6 months. P. gingivalis cell count in the test group was significantly reduced at all the time periods, except from 1 to 3 months.
  
  
  CONCLUSIONS
  Local drug delivery of doxycycline microspheres significantly improved the treatment outcomes in periodontal pocket therapy and reduced P. gingivalis in the periodontal pocket.
authors.affiliation: Department of Periodontics, Saraswati Dhanvantri Dental College and Hospital, Parbhani, Maharashtra, India. dr.rao.sampath@gmail.com
authors.forename: Sampath K
authors.initials: SK
authors.lastname: Rao
authors.forename: Swati
authors.initials: S
authors.lastname: Setty
authors.forename: Anirudh B
authors.initials: AB
authors.lastname: Acharya
authors.forename: Srinath L
authors.initials: SL
authors.lastname: Thakur
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000628:therapy*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000628:therapy; D016133:Polymerase Chain Reaction; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D016745:Root Planing; D016037:Single-Blind Method
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline