title: [Pathophysiology of preeclampsia: some recent data].
abstract: Placental ischemia is the background of the pathophysiology of preeclampsia. It is mainly - but not exclusively - caused by an immunological conflict between maternal NK cells of the decidua and of the uterine junctional zone, and the HLA-C antigens shared by interstitial trophoblast. The maternal disease is the consequence of the placental ischemia, and is characterized by an inflammatory syndrome with an oxidative stress and an endothelial cell dysfunction. Genetics play an essential part in each of these steps.
authors.affiliation: Pôle de gynécologie-obstétrique, médecine fœtale, reproduction humaine et orthogénie, CHU d'Angers, Angers cedex 9, France. a.fournie@neuf.fr
authors.forename: A
authors.initials: A
authors.lastname: Fournié
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D010064:Embryo Implantation / Q000235:genetics / Q000502:physiology; D005260:Female; D006801:Humans; D009774:Obstetrics / Q000379:methods / Q000639:trends; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents