title: [Function and biological activities of the autotaxin-LPA axis].
abstract: Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
authors.affiliation: Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China.
authors.forename: Zong-Wei
authors.initials: ZW
authors.lastname: Li
authors.forename: Ya-Rui
authors.initials: YR
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Zhao
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
authors.forename: Zhuo-Yu
authors.initials: ZY
authors.lastname: Li
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008246:Lysophospholipids / Q000378:metabolism / Q000502:physiology*; D010740:Phospholipases / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D000099189:Lysophospholipase D
chemical_list: D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D010740:Phospholipases; D010727:Phosphoric Diester Hydrolases; D043562:Receptors, G-Protein-Coupled; D000099189:Lysophospholipase D; C032881:lysophosphatidic acid