title: Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice fed a high-fat diet with fructose.
abstract: Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueous I. sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment with I. sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract from I. sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.
authors.affiliation: Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Prolongación de Carpio y Plan de Ayala s/n Colonia, Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 Mexico City, DF, Mexico.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Rivera-Ramírez
authors.forename: Gerardo N
authors.initials: GN
authors.lastname: Escalona-Cardoso
authors.forename: Leticia
authors.initials: L
authors.lastname: Garduño-Siciliano
authors.forename: Carlos
authors.initials: C
authors.lastname: Galaviz-Hernández
authors.forename: Norma
authors.initials: N
authors.lastname: Paniagua-Castro
mesh_terms: D000821:Animal Feed; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001835:Body Weight; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005632:Fructose / Q000737:chemistry*; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000188:drug therapy*; D010100:Oxygen / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D014280:Triglycerides / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts; D014280:Triglycerides; D014867:Water; D005632:Fructose; D010100:Oxygen