title: [An analysis of prognostic factors for malignant fibrous histiocytoma of bone].
abstract: OBJECTIVE
  To study the risk factors related to the survival rate, recurrence and metastasis of malignant fibrous histiocytoma of bone.
  
  
  METHODS
  From July 1997 and July 2010, 56 patients with malignant fibrous histiocytoma of bone were treated. Univariate and multivariate analysis were performed to determine the probable risk factors including gender, age, tumor location, tumor size and so on.
  
  
  RESULTS
  Forty-four cases were followed up ranged from 2 weeks to 78 months (medium 33.3). The 5-year overall survival rate was 50.1%, local recurrence rate 40.9% with a median time of 12 months (3 to 60 months) and metastatic rate 27.5% (11/40) with a median time of 6.5 months (2 to 23 months). Univariate analysis indicated that gender, condition of presentation (primary case or recurrence case), tumor location, surgical margin and surgical stage were significantly related to survival rate (P < 0.05), and tumor location and surgical margin were related to local recurrence rate (P < 0.05), and important vessel or nerve invasion was related to metastatic rate (P < 0.05). Multivariate analysis showed that surgical margin and surgical stage were independent risk factors for survival rate, of which surgical margin was the independent risk factor for recurrence rate.
  
  
  CONCLUSIONS
  Surgical margin and surgical stage are independent risk factors for survival rate, of which surgical margin is the independent risk factor for recurrence rate.
authors.affiliation: Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, China.
authors.forename: Guang-xue
authors.initials: GX
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Rong-li
authors.initials: RL
authors.lastname: Yang
authors.forename: Hua-yi
authors.initials: HY
authors.lastname: Qu
authors.forename: Shun
authors.initials: S
authors.lastname: Tang
authors.forename: Dian-wen
authors.initials: DW
authors.lastname: Qi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult