title: [Urinary levels of angiotensin-(1-7) and angiotensin II in patients with severe aortic stenosis].
abstract: OBJECTIVE
  Strengthen knowledge about the pathophysiology of aortic stenosis.
  
  
  METHODS
  Urinary levels of angiotensin-(1-7) and angiotensin II were compared between two samples: A) forty five patients with severe aortic stenosis, without systemic arterial hypertension and with normal kidney and normal left ventricular systolic function; B) control group: twenty one persons without cardiovascular disease.
  
  
  OBJECTIVE
  there would be no difference between urinary levels.
  
  
  RESULTS
  The average of angiotensin-(1-7) urinary concentration in severe aortic stenosis patients was 2.102 pmol/mL and 5.591 pmol/mL for the control group. The average of Ang II was 0.704 pmol/mL and 0.185 pmol/mL respectively. Using t-Student test, we determine that the difference in urinary concentration of angiotensin-(1-7) [p=0.633] and the difference of angiotensin II (p=0.631), were statistically significant.
  
  
  CONCLUSIONS
  documented a statistically significant difference in urinary levels angiotensin II and angiotensin-(1-7) within the group of patients with severe aortic stenosis.
authors.affiliation: Unidad de Estudios Avanzados en Hipertensión Arterial y Factores de Riesgo Cardiovascular.
authors.forename: César
authors.initials: C
authors.lastname: López-de la Vega
authors.forename: Martín
authors.initials: M
authors.lastname: Rosas-Peralta
authors.forename: Catalina
authors.initials: C
authors.lastname: Lomelí-Estrada
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pastelín-Hernández
authors.forename: Leonardo
authors.initials: L
authors.lastname: del Valle-Mondragón
mesh_terms: D000328:Adult; D000368:Aged; D000803:Angiotensin I / Q000652:urine*; D000804:Angiotensin II / Q000652:urine*; D001024:Aortic Valve Stenosis / Q000652:urine*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000652:urine*; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7)