title: Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs.
abstract: Multiple drug administration is an important aspect of clinical practice particularly in specific physiological situation such as in neonates, elderly or pregnancy, since in all such situations, possibility of unwanted effects increases due to altered body physiology. In present study, the teratogenic effects of multiple drug administration risperidone, meclizine/pyridoxine and hydralazine have been compared with the teratogenic effects of individual drugs in pregnant mice. Moreover the role of folic acid and α-tocopherol if any had also been investigated in reducing the teratogenic effects of these drugs in combinations.
authors.affiliation: Department of Pharmacology, University of Karachi, Karachi, Pakistan.
authors.forename: Shaista
authors.initials: S
authors.lastname: Tauqeer
authors.forename: Rafeeq Alam
authors.initials: RA
authors.lastname: Khan
authors.forename: Afaq Ahmed
authors.initials: AA
authors.lastname: Siddiqui
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000633:toxicity*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data*; D004347:Drug Interactions; D005260:Female; D020567:Fetal Weight / Q000187:drug effects; D006830:Hydralazine / Q000008:administration & dosage / Q000633:toxicity; D008468:Meclizine / Q000008:administration & dosage / Q000633:toxicity; D051379:Mice; D011736:Pyridoxine / Q000627:therapeutic use*; D018967:Risperidone / Q000008:administration & dosage / Q000633:toxicity*; D050497:Stillbirth; D024502:alpha-Tocopherol / Q000627:therapeutic use*
chemical_list: D000932:Antiemetics; D000959:Antihypertensive Agents; D006830:Hydralazine; D008468:Meclizine; D024502:alpha-Tocopherol; D011736:Pyridoxine; D018967:Risperidone