title: Fatal disseminated Cryptococcus gattii infection in New Mexico.
abstract: We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.
authors.affiliation: Section of Infectious Diseases, New Mexico Veterans Healthcare System, Albuquerque, New Mexico, United States of America.
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Walraven
authors.forename: Wendy
authors.initials: W
authors.lastname: Gerstein
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hardison
authors.forename: Floyd
authors.initials: F
authors.lastname: Wormley
authors.forename: Shawn R
authors.initials: SR
authors.lastname: Lockhart
authors.forename: Julie R
authors.initials: JR
authors.lastname: Harris
authors.forename: Annette
authors.initials: A
authors.lastname: Fothergill
authors.forename: Brian
authors.initials: B
authors.lastname: Wickes
authors.forename: Julie
authors.initials: J
authors.lastname: Gober-Wilcox
authors.forename: Larry
authors.initials: L
authors.lastname: Massie
authors.forename: T S Neil
authors.initials: TS
authors.lastname: Ku
authors.forename: Carolina
authors.initials: C
authors.lastname: Firacative
authors.forename: Wieland
authors.initials: W
authors.lastname: Meyer
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Lee
mesh_terms: D000818:Animals; D001344:Autopsy; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000382:microbiology* / Q000473:pathology; D056285:Cryptococcus gattii / Q000145:classification / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D017809:Fatal Outcome; D005838:Genotype; D006801:Humans; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D009516:New Mexico; D010802:Phylogeny; D014774:Virulence