title: Natural orifice transluminal endoscopic surgery for patients with perforated peptic ulcer.
abstract: BACKGROUND
  Perforation accounts for 70% of deaths attributed to peptic ulcers. Laparoscopic repair is effective but infrequently used. Our aim was to assess how many patients with perforated peptic ulcer could be candidates for a transluminal endoscopic omental patch closure.
  
  
  METHODS
  This retrospective study reviewed patients with perforated peptic ulcer from 2005 to 2010. Demographics, ulcer characteristics, operative procedure, and outcomes were recorded. Candidates for endoscopic transluminal repair were defined as those having undergone omental patch closure of an ulcer of appropriate size and no contraindications to laparoscopy or endoscopy.
  
  
  RESULTS
  In the retrospective review, a total of 104 patients were identified; 62% female, mean age = 68 years, mean ASA of 3, and 63% medication-related ulcers. Fifty-nine (63%) had an omental patch (80% open), and 35 (37%) had other procedures. Ten patients had nonoperative management. Thirty-day mortality was 14% and 1 year mortality was 35%. Forty-nine patients (52%) were considered potential candidates for transluminal repair.
  
  
  CONCLUSIONS
  Sixty-three percent of our patients sustained a medication-related perforation with 1 year mortality of 35%. The majority of patients were treated using open omental patch repair. Transluminal endoscopic repair may provide an additional situation for a minimally invasive approach for a number of these patients.
authors.affiliation: Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Bonin
authors.forename: Erica
authors.initials: E
authors.lastname: Moran
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gostout
authors.forename: Andrea L
authors.initials: AL
authors.lastname: McConico
authors.forename: Martin
authors.initials: M
authors.lastname: Zielinski
authors.forename: Juliane
authors.initials: J
authors.lastname: Bingener
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000601:surgery*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D009852:Omentum / Q000637:transplantation*; D010439:Peptic Ulcer Perforation / Q000601:surgery*; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000601:surgery*; D013524:Surgical Flaps; D016896:Treatment Outcome; D055815:Young Adult