title: Intra-arterial delivery of cell therapies for stroke.
abstract: Cell therapy is a novel investigational approach to enhance stroke recovery. Intra-arterial (IA) delivery has the potential advantage of selectively targeting cell therapies to the ischemic brain tissue. Over the past 10 years, IA cell delivery has been under investigation in patients with cardiac and peripheral vascular disease, and these studies have reported promising results. This article reviews the trial methodology and procedural details of these studies and discusses the rationale and challenges in designing IA cell therapy trials for ischemic stroke.
authors.affiliation: Department of Neurology, University of Texas Medical School at Houston, UT-Health, Houston, TX 77030, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Misra
authors.forename: Aditya
authors.initials: A
authors.lastname: Lal
authors.forename: Ramy
authors.initials: R
authors.lastname: El Khoury
authors.forename: Peng R
authors.initials: PR
authors.lastname: Chen
authors.forename: Sean I
authors.initials: SI
authors.lastname: Savitz
mesh_terms: D000818:Animals; D017690:Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D002986:Clinical Trials as Topic; D006801:Humans; D007269:Injections, Intra-Arterial; D009422:Nervous System Diseases / Q000628:therapy; D020521:Stroke / Q000628:therapy*