title: Should diabetic women with breast cancer have their own intervention studies?
abstract: This commentary on 'Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity' by Nogueira et al., published in this issue of Endocrine-Related Cancer, addresses the challenges of translating diet, exercise, and pharmacologic trials in diabetic mouse mammary tumor models to human studies. We propose that trials specifically designed to test such interventions in diabetic women with breast cancer would be valuable and informative.
authors.affiliation: Division of Hematology, Oncology and Transplantation, Masonic Cancer Center, University of Minnesota, 420 Delaware Street SouthEast, MMC 480, Minneapolis, Minnesota 55455-0392, USA. dapotter@umn.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Potter
authors.forename: Douglas
authors.initials: D
authors.lastname: Yee
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Guo
authors.forename: Mariangellys
authors.initials: M
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control*; D031204:Caloric Restriction; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000517:prevention & control*; D004035:Diet Therapy; D015444:Exercise; D005260:Female; D006801:Humans; D051379:Mice; D009765:Obesity / Q000150:complications / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents