title: Premature decline of serum total testosterone in HIV-infected men in the HAART-era.
abstract: BACKGROUND
  Testosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T.
  
  
  RESULTS
  We performed a cross-sectional, observational study on 1325 consecutive HIV male outpatients, most of them having lipodystrophy. Serum total T<300 ng/dL was used as the threshold for biochemical T deficiency. Morning serum total T, luteinizing hormone (LH), estradiol, HIV parameters, and body composition parameters by CT-scan and Dual-Energy-X-ray-Absorptiometry were measured in each case. Sexual behavior was evaluated in a subset of 247 patients. T deficiency was found in 212 subjects, especially in the age range 40-59, but was frequent even in younger patients. T deficiency occurred mainly in association with low/normal serum LH. Adiposity was higher in subjects with T deficiency (p<0.0001) and both visceral adipose tissue and body mass index were the main negative predictors of serum total T. Osteoporosis and erectile dysfunction were present in a similar percentage in men with or without T deficiency.
  
  
  CONCLUSIONS
  Premature decline of serum T is common (16%) among young/middle-aged HIV-infected men and is associated with inappropriately low/normal LH and increased visceral fat. T deficiency occurs at a young age and may be considered an element of the process of premature or accelerated aging known to be associated with HIV infection. The role of HIV and/or HIV infection treatments, as well as the role of the general health state on the gonadal axis, remains, in fact, to be elucidated. Due to the low specificity of signs and symptoms of hypogonadism in the context of HIV, caution is needed in the diagnosis of hypogonadism in HIV-infected men with biochemical low serum T levels.
authors.affiliation: Chair and Unit of Endocrinology & Metabolism, Department of Medicine, Endocrinology & Metabolism, Geriatrics, University of Modena & Reggio Emilia, Azienda AUSL-NOCSAE of Baggiovara, Modena, Italy. vincenzo.rochira@unimore.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rochira
authors.forename: Lucia
authors.initials: L
authors.lastname: Zirilli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Orlando
authors.forename: Daniele
authors.initials: D
authors.lastname: Santi
authors.forename: Giulia
authors.initials: G
authors.lastname: Brigante
authors.forename: Chiara
authors.initials: C
authors.lastname: Diazzi
authors.forename: Federica
authors.initials: F
authors.lastname: Carli
authors.forename: Cesare
authors.initials: C
authors.lastname: Carani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Guaraldi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000502:physiology; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone