title: Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study.
abstract: In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.
authors.affiliation: CRAMC, Department of Psychology, Universitat Rovira i Virgili, Tarragona, Catalonia, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Heredia
authors.forename: Margarita
authors.initials: M
authors.lastname: Torrente
authors.forename: María T
authors.initials: MT
authors.lastname: Colomina
authors.forename: José L
authors.initials: JL
authors.lastname: Domingo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D005411:Flame Retardants / Q000494:pharmacology*; D055768:Halogenated Diphenyl Ethers / Q000494:pharmacology*; D008027:Light; D008297:Male; D018782:Maze Learning; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; C010902:decabromobiphenyl ether