title: [Acute profound thrombocytopenia associated with the use of abciximab: case report].
abstract: We present the case-report of a patient with instable angina who submitted to percutaneous coronary intervention and stent place for revascularization who developed purpura and groin hematoma associated to acute profound thrombocytopenia induced by abciximab infusion with nadir platelet counts 1x10⁹/L (1,000 platelets/mm3), his platelet recovery with the instituted treatment and the outcome with subacute intra-stent thrombosis that was associated with functionally platelet counts that required a primary angioplasty and administration of tirofiban, a platelet glycoprotein IIb/IIIa receptor antagonist. Laboratory confirmation to exclude other causes of thrombocytopenia and its association of glycoprotein IIb/IIIa receptor antagonist with heparin, acetylsalicylic acid and clopidogrel were obtained. We perform in literature trials with this complication.
authors.affiliation: Servicio de Medicina Interna.
authors.forename: Bernardino
authors.initials: B
authors.lastname: Álvarez-Camarena
authors.forename: Enrique
authors.initials: E
authors.lastname: Frutos-Rangel
authors.forename: Enrique
authors.initials: E
authors.lastname: Rico-Curiel
authors.forename: José María
authors.initials: JM
authors.lastname: García-y Otero
authors.forename: Enrique
authors.initials: E
authors.lastname: Frutos-Rodríguez
mesh_terms: D000077284:Abciximab; D000208:Acute Disease; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab