title: Molecular interactions of proteins and peptides at interfaces studied by sum frequency generation vibrational spectroscopy.
abstract: Interfacial peptides and proteins are critical in many biological processes and thus are of interest to various research fields. To study these processes, surface sensitive techniques are required to completely describe different interfacial interactions intrinsic to many complicated processes. Sum frequency generation (SFG) spectroscopy has been developed into a powerful tool to investigate these interactions and mechanisms of a variety of interfacial peptides and proteins. It has been shown that SFG has intrinsic surface sensitivity and the ability to acquire conformation, orientation, and ordering information about these systems. This paper reviews recent studies on peptide/protein-substrate interactions, peptide/protein-membrane interactions, and protein complexes at interfaces and demonstrates the ability of SFG on unveiling the molecular pictures of complicated interfacial biological processes.
authors.affiliation: Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Liu
authors.forename: Joshua
authors.initials: J
authors.lastname: Jasensky
authors.forename: Zhan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D055620:Optical Phenomena; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods*; D014732:Vibration
chemical_list: D010455:Peptides; D011506:Proteins