title: Type I interferon pathway in adult and juvenile dermatomyositis.
abstract: Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.
authors.affiliation: Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Baechler
authors.forename: Hatice
authors.initials: H
authors.lastname: Bilgic
authors.forename: Ann M
authors.initials: AM
authors.lastname: Reed
mesh_terms: D000328:Adult; D002648:Child; D003882:Dermatomyositis / Q000097:blood / Q000235:genetics* / Q000473:pathology; D020869:Gene Expression Profiling; D006801:Humans; D007370:Interferon Type I / Q000097:blood / Q000235:genetics*; D016898:Interferon-alpha / Q000097:blood / Q000235:genetics*; D016899:Interferon-beta / Q000097:blood / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; C063743:interferon omega 1; D016899:Interferon-beta