title: Correlation of levels of interleukin-1β in gingival crevicular fluid to the clinical parameters of chronic periodontitis.
abstract: OBJECTIVE
  
  
  
  OBJECTIVE
  IL-1β is a potent stimulator of bone resorption and has been implicated in the pathogenesis of periodontal destruction. Therefore, this study was designed to compare the levels of IL-1β of chronic periodontitis patients with the healthy subjects. Another objective of this study was to correlate IL-1β levels with the clinical parameters of the periodontal disease progression.
  
  
  METHODS
  For this study, total 60 subjects were chosen (30- healthy and 30-chronic periodontitis). Simplified oral hygiene index (OHI-S), gingival index (GI), periodontal disease index (PDI), probing depth (PD), tooth mobility, bleeding on probing (BOP) were recorded for all the subject. Gingival crevicular fluid (GCF) was collected and subjected for ELISA for estimation of IL-1β.
  
  
  RESULTS
  At the periodontal diseased sites, the IL-1β levels increased at least 2-fold as compared with healthy subjects. This increase was highly significant (p = 0.0000). Within the test group, IL-1β levels correlated positively and significantly with PDI, PD, BOP and tooth mobility. The correlations of IL-1β with PD (p = 0.000) and IL-1β with BOP (p = 0.0004) were highly significant.
  
  
  CONCLUSIONS
  These data suggest that amount of GCF IL-1β is closely associated with periodontal status. This relationship may be valuable in monitoring periodontal disease activity.
  
  
  CONCLUSIONS
  It could be stated from this study on IL- 1β that there seem to be a strong correlation between periodontal tissue destruction and IL-1β. Furthermore IL-1β level could also differentiate between active and inactive periodontal lesions.
authors.affiliation: Department of Periodontology, Bharati Vidyapeeth Deemed University, Dental College and Hospital, Pune Maharashtra, India. amit_ch001@yahoo.co.in
authors.forename: A U
authors.initials: AU
authors.lastname: Chaudhari
authors.forename: G N
authors.initials: GN
authors.lastname: Byakod
authors.forename: P F
authors.initials: PF
authors.lastname: Waghmare
authors.forename: V M
authors.initials: VM
authors.lastname: Karhadkar
mesh_terms: D015415:Biomarkers / Q000032:analysis; D055113:Chronic Periodontitis / Q000145:classification / Q000276:immunology*; D018450:Disease Progression; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D005884:Gingival Hemorrhage / Q000145:classification / Q000276:immunology; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis*; D009911:Oral Hygiene Index; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000276:immunology; D014086:Tooth Mobility / Q000145:classification / Q000276:immunology
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta