title: New bicyclo[3.1.0]hexane unit ent-kaurane diterpene and its seco-derivative from Isodon eriocalyx var. laxiflora.
abstract: Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The absolute configuration of 1 was determined by spectral methods and single crystal X-ray diffraction analysis. Compound 4 and the synthesized compound 5 exhibited significant cytotoxicity.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wu
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Liang
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003510:Cyclohexanes / Q000737:chemistry*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D001643:Bridged Bicyclo Compounds; D003510:Cyclohexanes; D045786:Diterpenes, Kaurane