title: Targeted nanotherapy for induction of therapeutic immune responses.
abstract: Nanotechnology permits the design of therapeutic devices with defined structure and molecular composition. Modular designs employing surface-bound ligands provide specific homing devices for loaded cargo, and biocompatible and biodegradable constructs provide surrogate temporary microenvironments. We first present a case for developing 'smart' modular constructs as immunogenic vaccines to prime immune memory against specific pathogens where current vaccines fail. Second, we argue that nanotherapeutic intervention can harness pivotal molecular pathways recently discovered to regulate lineage development between pathogenic TH17 cells associated with autoimmune disease, versus tolerogenic regulatory T cells (Treg). Underpinned by molecular mechanisms that enable exquisitely specific responses in adaptive immunity, targeted nanodevices designed to stimulate either immune aggression or immune tolerance signify the birth of a new era in therapeutics.
authors.affiliation: Cambridge Center for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK. smm1001@cam.ac.uk
authors.forename: Su M
authors.initials: SM
authors.lastname: Metcalfe
authors.forename: Tarek M
authors.initials: TM
authors.lastname: Fahmy
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control*; D003713:Dendritic Cells / Q000166:cytology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000008:administration & dosage / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology / Q000517:prevention & control; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D053605:Leukemia Inhibitory Factor; D014612:Vaccines