title: Thyroid gland involvement in advanced laryngeal cancer: association with clinical and pathologic characteristics.
abstract: BACKGROUND
  Indications for thyroidectomy during laryngectomy are controversial. We examined whether clinicopathologic features can predict thyroid gland involvement, and the prognostic effect of thyroid gland involvement in patients undergoing total laryngectomy.
  
  
  METHODS
  The study set out to review preoperative assessment, operation findings, pathologic findings, and follow-up data.
  
  
  RESULTS
  Thyroid gland involvement was found in 11 of 53 patients (21%) undergoing total laryngectomy and thyroidectomy. Preoperative work-up failed to predict thyroid gland involvement. Thyroid gland involvement was associated with salvage procedures (p = .025), paratracheal metastases (p = .003), and poor overall survival (hazard ratio = 2.74, p = .008).
  
  
  CONCLUSIONS
  Thyroid gland involvement in patients undergoing total laryngectomy is frequent and is associated with poor prognosis. Preoperative assessment failed to predict thyroid gland involvement. We believe that thyroidectomy should be considered in cases with paratracheal lymphatic spread irrespective of tumor location within the larynx.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. hillyo@clalit.org.il
authors.forename: Ohad
authors.initials: O
authors.lastname: Hilly
authors.forename: Raanan
authors.initials: R
authors.lastname: Raz
authors.forename: Yona
authors.initials: Y
authors.lastname: Vaisbuch
authors.forename: Yulia
authors.initials: Y
authors.lastname: Strenov
authors.forename: Karl
authors.initials: K
authors.lastname: Segal
authors.forename: Rumelia
authors.initials: R
authors.lastname: Koren
authors.forename: Jacob
authors.initials: J
authors.lastname: Shvero
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000556:secondary / Q000601:surgery