title: Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
authors.affiliation: Pharmasset, Inc., 303A College Road East, Princeton, New Jersey 08540, United States. Michael.sofia@pharmasset.com
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sofia
authors.forename: Wonsuk
authors.initials: W
authors.lastname: Chang
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Furman
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Ross
mesh_terms: D000495:Allosteric Site; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D020134:Catalytic Domain; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D016679:Genome, Viral; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008958:Models, Molecular; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D009711:Nucleotides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D011487:Protein Conformation; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D009711:Nucleotides; D011355:Prodrugs; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase