title: Vogt-Koyanagi-Harada disease, diabetes mellitus, and psoriasis in a child.
abstract: OBJECTIVE
  To report a case of a child with near-simultaneous onset of Vogt Koyanagi Harada disease (VKH) and insulin-dependent diabetes mellitus (IDDM).
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  An 11-year-old child with known psoriasis presented with headache and bilateral granulomatous panuveitis. Nine weeks later, he presented with diabetic ketoacidosis and IDDM. Diffuse choroidal depigmentation followed within months. HLA was positive for DRB1*0405. Despite aggressive local and systemic therapy, the ocular disease was complicated by bilateral cataracts, angle closure glaucoma, and choroidal neovascularization.
  
  
  RESULTS
  The patient is currently pseudophakic in one eye and aphakic in the other, with best-corrected visual acuity of 6/24 and 6/5, respectively.
  
  
  CONCLUSIONS
  VKH may present in children with panuveitis in the setting of other autoimmune disorders. Treating such patients is complicated by the need to minimize systemic corticosteroid use. A combination of local therapy and systemic steroid-sparing agents should be the mainstay of treatment.
authors.forename: Elvis
authors.initials: E
authors.lastname: Ojaimi
authors.forename: Jaime
authors.initials: J
authors.lastname: Levy
authors.forename: Richard
authors.initials: R
authors.lastname: Stawell
authors.forename: Anton
authors.initials: A
authors.lastname: Van Heerden
authors.forename: Tim
authors.initials: T
authors.lastname: Godfrey
authors.forename: Ehud
authors.initials: E
authors.lastname: Zamir
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009887:Ophthalmoscopy; D011565:Psoriasis / Q000150:complications*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000175:diagnosis; D014792:Visual Acuity