title: Subcutaneous dissemination pattern in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma.
abstract: BACKGROUND
  Mucosa-associated lymphoid tissue (MALT) lymphoma is among the most common forms of extranodal lymphomas, but little is known about subcutaneous involvement in patients with non-primary cutaneous marginal zone lymphomas.
  
  
  METHODS
  Patients with MALT lymphoma diagnosed and treated at our institution between 1999 and 2010 were analyzed for subcutaneous deposits from MALT lymphoma diagnosed in another organ. Histological, clinical and genetic findings were assessed.
  
  
  RESULTS
  Among 216 patients with MALT lymphoma, 12 had subcutaneous deposits from MALT lymphoma (5.5%). In two patients, these lesions were present at diagnosis, while they constituted the site of relapse at an interval between 5 to 144 months in the remaining cases. Interestingly, nine of the 12 patients with subcutaneous deposits had originally been diagnosed with MALT lymphoma of the ocular adnexa (total number=51; 20%), and the other three had MALT lymphoma in the breast (total number=5; 60%). None of the patients with gastric (n=86), salivary gland (n=32) or pulmonary (n=19) MALT lymphomas had subcutaneous involvement during a median follow-up time of 87 months (range; 4 to 119 months).
  
  
  CONCLUSIONS
  Our data show that subcutaneous MALT lymphoma involvement is a rare event in patients with prior non-cutaneous extranodal marginal zone lymphoma. However, it seems to be almost exclusively associated with MALT lymphoma of the ocular adnexa and the breast, suggesting as yet undefined interactions between potentially embryonically related organ systems.
authors.affiliation: Department of Dermatology, Internal Medicine I, Comprehensive Cancer Center, Medical University Vienna, Wilheminenspital, Vienna, Austria.
authors.forename: Constanze
authors.initials: C
authors.lastname: Jonak
authors.forename: Marlene
authors.initials: M
authors.lastname: Troch
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiesewetter
authors.forename: Julius
authors.initials: J
authors.lastname: Lukas
authors.forename: Leonhard
authors.initials: L
authors.lastname: Müllauer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jäger
authors.forename: Andreas
authors.initials: A
authors.lastname: Chott
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000556:secondary* / Q000628:therapy; D013274:Stomach Neoplasms / Q000556:secondary* / Q000628:therapy