title: Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis.
abstract: Numerous  studies have evaluated the association between human leukocyte antigen (HLA)  Cw*0602 polymorphism and psoriasis risk. However, the results have been  inconsistent. We made a meta-analysis of the association between HLA-Cw*0602  polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a  total of 3419 psoriasis patients and 3297 healthy controls. The associations  between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled  odds ratio (OR) and 95% confidence interval (95%CI). We found significant  associations between HLA-Cw*0602 polymorphism and psoriasis risk in the  comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67,  P < 0.00001); positive homozygote versus negative homozygote combined with  heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P < 0.00001); positive  homozygote combined with heterozygote versus negative homozygote (OR = 5.11,  95%CI = 3.86-6.76, P < 0.00001); positive homozygote versus negative  homozygote (OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001), and positive  homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35- 7.00, P < 0.00001).  In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a  risk factor for psoriasis.
authors.affiliation: Department of Dermatology, Beihua Affiliated Hospital, Jilin, China.
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D016206:Databases, Bibliographic; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*; D012306:Risk; D044465:White People
chemical_list: D015236:HLA-C Antigens