title: Peptide-antibody complex as handle for single-molecule cut & paste.
abstract: Molecule-by-molecule arrangement of proteins, for example, in enzymatic networks of predefined composition and proximity, is a major goal that may be accomplished by the single-molecule cut-and-paste technique (SMC&P). For this purpose, co-expressed anchors and handles as protein tags should be employed. As a first step in this direction, the authors develop an SMC&P design which exploits an antibody-peptide complex as a molecular handle.
authors.affiliation: Center for Nanoscience and Department of Physics, University of Munich, Amalienstrasse 54, 80799 München, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Strackharn
authors.forename: Stefan W
authors.initials: SW
authors.lastname: Stahl
authors.forename: Philip M D
authors.initials: PM
authors.lastname: Severin
authors.forename: Thomas
authors.initials: T
authors.lastname: Nicolaus
authors.forename: Hermann E
authors.initials: HE
authors.lastname: Gaub
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000378:metabolism*; D000936:Antigen-Antibody Complex / Q000737:chemistry / Q000378:metabolism*; D020527:Microscopy, Scanning Probe; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D010455:Peptides