title: Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside             in hyperlipidemic rats induced by a high-fat diet.
abstract: Kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside (A-F-B) is a novel             flavonoid which is extracted from the leaves of Actinidia kolomikta. The aim of             this study was to investigate the hypolipidemic effects of A-F-B in hyperlipidemic             rats induced by a high-fat diet. Male Wistar rats were randomly divided into six             groups: normal diet group, high-fat diet group, lovastatin (2.5 mg/kg) group and             A-F-B (12.5, 25 or 50 mg/kg) groups. To evaluate the lipid-lowering effects of             A-F-B, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol             (LDL-C), high-density lipoprotein cholesterol (HDL-C), atherogenic index (AI)             and coronary risk index (CRI) were investigated. The activities of phosphatidate             phosphohydrolase (PAP) and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase             in hepatic tissue were evaluated. Treatment with A-F-B to hyperlipidemic rats             resulted in a significant decline in TC, TG, LDL-C, AI and CRI, with an increase             in HDL-C level. The results also showed that A-F-B significantly decreased the             activities of PAP and HMG-CoA reductase in hepatic tissue. These findings suggest             that A-F-B improves lipid profiles. The mechanisms of A-F-B were associated with             regulating the activities of PAP and HMG-CoA reductase in hepatic tissue.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, PR China.
authors.forename: Xue-Zhong
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Xu-Wen
authors.initials: XW
authors.lastname: Li
authors.forename: Yong-Ri
authors.initials: YR
authors.lastname: Jin
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yu
authors.forename: Shao-Chun
authors.initials: SC
authors.lastname: Qu
authors.forename: Da-Yuan
authors.initials: DY
authors.lastname: Sui
mesh_terms: D029042:Actinidia / Q000737:chemistry; D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004789:Enzyme Activation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy / Q000209:etiology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044949:Kaempferols / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008148:Lovastatin / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010711:Phosphatidate Phosphatase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006027:Glycosides; D000960:Hypolipidemic Agents; D044949:Kaempferols; D010936:Plant Extracts; D014280:Triglycerides; C571783:kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside; D002784:Cholesterol; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases; D010711:Phosphatidate Phosphatase