title: Lung cancer following bronchoscopic lung volume reduction for severe emphysema: a case and its management.
abstract: Bronchoscopic lung volume reduction using endobronchial valves has been suggested as a potentially safer alternative to surgery in selected cases. Complications of this technique include pneumothoraces, pneumonia, COPD exacerbations, hemoptysis, and valve migrations. We report the case of a male patient who developed a parenchymal mass in the treated lobe after valve insertion. Due to severe emphysema, transthoracic needle aspiration was not feasible. Removal of the valves was mandatory to perform transbronchialbiopsies which revealed a non-small cell primary lung cancer. This first description illustrates the potential risk of lung cancer development following bronchoscopic lung volume reduction and highlights the different approach to diagnosis and management of indeterminate peripheral lung lesions needed in this context.
authors.affiliation: Department of Pulmonology and Allergology, North University Hospital, Marseille, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Tummino
authors.forename: Fabien
authors.initials: F
authors.lastname: Maldonado
authors.forename: Sophie
authors.initials: S
authors.lastname: Laroumagne
authors.forename: Philippe
authors.initials: P
authors.lastname: Astoul
authors.forename: Hervé
authors.initials: H
authors.lastname: Dutau
mesh_terms: D000368:Aged; D001999:Bronchoscopy; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D011013:Pneumonectomy; D011656:Pulmonary Emphysema / Q000601:surgery*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed