title: Aortic valve repair via neo-chordae technique: mechanistic insight through numerical modelling.
abstract: Recently, the neo-chordae technique (NCT) was proposed to stabilize the surgical correction of isolated aortic valve (AV) prolapse. Neo-chordae are inserted into the corrected leaflet to drive its closure by minimal tensions and prevent relapses. In a previous in vitro study we analysed the NCT effects on healthy aortic roots (ARs). Here we extend that analysis via finite element models (FEMs). After successfully replicating the experimental conditions for validation purposes, we modified our AR FEM, obtaining a continent AV with minor isolated prolapse, thus representing a realistic clinical scenario. We then simulated the NCT, and systematically assessed the acute effects of changing neo-chordae length, opening angle, asymmetry and insertion on the aorta. In the baseline configuration the NCT restored physiological AV dynamics and coaptation, without inducing abnormal leaflet stresses. This outcome was notably sensitive only to neo-chordae length, suggesting that the NCT is a potentially easy-to-standardize technique. However, this parameter is crucial: major shortenings (6 mm) prevent coaptation and increase leaflet stresses by 359 kPa, beyond the yield limit. Minor shortenings (2-4 mm) only induce a negligible stress increase and mild leaflet tethering, which however may hamper the long-term surgical outcome.
authors.affiliation: Department of Bioengineering, Politecnico di Milano, Via Golgi 39, 20133 Milan, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Votta
authors.forename: Luca
authors.initials: L
authors.lastname: Paroni
authors.forename: Carlo A
authors.initials: CA
authors.lastname: Conti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pelosi
authors.forename: Andrea
authors.initials: A
authors.lastname: Mangini
authors.forename: Paolo
authors.initials: P
authors.lastname: D'Alesio
authors.forename: Riccardo
authors.initials: R
authors.lastname: Vismara
authors.forename: Carlo
authors.initials: C
authors.lastname: Antona
authors.forename: Alberto
authors.initials: A
authors.lastname: Redaelli
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001023:Aortic Valve Prolapse / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D058385:Cardiac Valve Annuloplasty / Q000379:methods*; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular