title: IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models.
abstract: Polymer micelles are promising drug delivery vehicles for the delivery of anticancer agents to tumors. Often, anticancer drugs display potent cytotoxic effects towards cancer cells but are too hydrophobic to be administered in the clinic as a free drug. To address this problem, a polymer micelle was designed using a triblock copolymer (ITP-101) that enables hydrophobic drugs to be encapsulated. An SN-38 encapsulated micelle, IT-141, was prepared that exhibited potent in vitro cytotoxicity against a wide array of cancer cell lines. In a mouse model, pharmacokinetic analysis revealed that IT-141 had a much longer circulation time, plasma exposure, and tumor exposure compared to irinotecan. IT-141 was also superior to irinotecan in terms of antitumor activity, exhibiting greater tumor inhibition in HT-29 and HCT116 colorectal cancer xenograft models at half the dose of irinotecan. The antitumor effect of IT-141 was dose-dependent and caused complete growth inhibition and tumor regression at well-tolerated doses. Varying the specific concentration of SN-38 within the IT-141 micelle had no detectible effect on this antitumor activity, indicating no differences in activity between different IT-141 formulations. In summary, IT-141 is a potent micelle-based chemotherapy that holds promise for the treatment of colorectal cancer.
authors.affiliation: Intezyne, Inc, 3720 Spectrum Boulevard Suite 104, Tampa, FL 33612, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Carie
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rios-Doria
authors.forename: Tara
authors.initials: T
authors.lastname: Costich
authors.forename: Brian
authors.initials: B
authors.lastname: Burke
authors.forename: Richard
authors.initials: R
authors.lastname: Slama
authors.forename: Habib
authors.initials: H
authors.lastname: Skaff
authors.forename: Kevin
authors.initials: K
authors.lastname: Sill