title: Polymorphisms in Th1/Th2 cytokine genes, hormone replacement therapy, and risk of non-Hodgkin lymphoma.
abstract: We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between hormone replacement therapy (HRT) and risk of non-Hodgkin lymphoma (NHL). Compared to women without a history of HRT use, women with a history of HRT use had a significantly decreased risk of NHL if they carried IFNGR2 (rs1059293) CT/TT genotypes (OR = 0.5, 95%CI: 0.3-0.9), IL13 (rs20541) GG genotype (OR = 0.6, 95%CI: 0.4-0.9), and IL13 (rs1295686) CC genotype (OR = 0.6, 95%CI: 0.4-0.8), but not among women who carried IFNGR2 CC, IL13 AG/AA, and IL13CT/TT genotypes. A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. A statistically significant interaction was observed for IFNGR2 (rs1059293 P(for interaction) = 0.024), IL13(rs20541 P(for interaction) = 0.005), IL13 (rs1295686 P(for interaction) = 0.008), and IL15RA (rs2296135 P(for interaction) = 0.049) for NHL overall; IL13 (rs20541 P(for interaction) = 0.0009), IL13(rs1295686 P(for interaction) = 0.0002), and IL15RA (rs2296135 P(for interaction) = 0.041) for B-cell lymphoma. The results suggest that common genetic variation in Th1/Th2 pathway genes may modify the association between HRT and NHL risk.
authors.affiliation: Gansu Provincial Academy of Medical Sciences, Gansu Provincial Tumor Hospital, Lanzhou, China.
authors.forename: Gongjian
authors.initials: G
authors.lastname: Zhu
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Pan
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Chen
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.forename: Christopher
authors.initials: C
authors.lastname: Kim
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Bi
authors.forename: Theodore
authors.initials: T
authors.lastname: Holford
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang