title: Effect of bilastine upon nasal obstruction.
abstract: H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these drugs have been considered effective in controlling sneezing, rhinorrhea and itching, though they have not been regarded as particularly effective in application to nasal obstruction. The most recent studies, involving second-generation H1 antihistamines (desloratadine, fexofenadine, levocetirizine, rupatadine), have shown these drugs to offer effects upon nasal obstruction significantly superior to those of placebo. The present review examines the effect of bilastine, a new, potent and highly specific H1 antihistamine without sedative effects or cardiac toxicity, upon nasal obstruction. The analysis of the data from the different clinical trials indicates that in patients with allergic rhinitis, the effect of bilastine upon nasal obstruction is superior to that of placebo and similar to that of other second-generation H1 antihistamines, manifesting within 24 hours after the start of treatment.
authors.affiliation: Department of Immunoallergy, Salamanca University Healthcare Complex, Salamanca, Spain. idg@usal.es
authors.forename: I
authors.initials: I
authors.lastname: Dávila
authors.forename: J
authors.initials: J
authors.lastname: Sastre
authors.forename: J
authors.initials: J
authors.lastname: Mullol
authors.forename: J
authors.initials: J
authors.lastname: Montoro
authors.forename: I
authors.initials: I
authors.lastname: Jáuregui
authors.forename: M
authors.initials: M
authors.lastname: Ferrer
authors.forename: A
authors.initials: A
authors.lastname: del Cuvillo
authors.forename: J
authors.initials: J
authors.lastname: Bartra
authors.forename: A
authors.initials: A
authors.lastname: Valero
mesh_terms: D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D015508:Nasal Obstruction / Q000188:drug therapy*; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy
chemical_list: D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D010880:Piperidines; C445659:bilastine