title: [Vitamin D status in osteoporotic postmenopausal women taking oral recommended vitamin D supplementation].
abstract: OBJECTIVE
  To assess the effectiveness of currently recommended daily intakes of vitamin D (25[OH]D) to bring optimal serum concentrations (30ng/ml) in postmenopausal osteoporotic women.
  
  
  METHODS
  We reviewed 25(OH)D serum concentrations in 165 consecutive osteoporotic postmenopausal women who were taking oral vitamin D daily supplements above 800IU during at least 3 months. The proportion of patients who achieved 25(OH)D levels of 20, 30 and 40ng/ml were compared according to daily vitamin D intakes (group 1: 800-1,000IU, group 2: 1,001-1,600IU, group 3:>1,600IU).
  
  
  RESULTS
  Mean patient age was 69 (10) years. Percentage of patients with serum 25(OH)D levels above 20ng/ml was 79.5% (63.5-88.5%), 92.7%(78.7-96%) and 97.6% (90.6-100%) in group 1, 2, and 3 patients, respectively (P=.009). Serum levels above 30ng/ml were achieved in 27.7% (14.7-44.7%), 53.6% (37.6-70%) and 90.2% (81.2-96.6%), respectively (P<.001). Serum levels above 40ng/ml were reached in 7.2% (1-20%), 24.4% (12-40%) and 61% (49-72%), respectively (P<.001).
  
  
  CONCLUSIONS
  Daily reference intakes of vitamin D supplements (800-1,000IU) may be insufficient to achieve optimal serum levels of vitamin D in postmenopausal osteoporotic women.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Dr. Peset, Valencia, Spain. ivorra_jos@gva.es
authors.forename: José
authors.initials: J
authors.lastname: Ivorra
authors.forename: Elia
authors.initials: E
authors.lastname: Valls
authors.forename: Nagore
authors.initials: N
authors.lastname: Fernández-Llanio Comella
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Chalmeta Verdejo
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Oliver Oliver
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Román Ivorra
mesh_terms: D000284:Administration, Oral; D000368:Aged; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008875:Middle Aged; D018673:Nutrition Policy; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies; D012015:Reference Standards; D017211:Treatment Failure; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D