title: Toxic epidermal necrolysis: review of pathogenesis and management.
abstract: Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction with a mortality rate of approximately 30%. The hallmark of TEN is widespread epidermal sloughing due to keratinocyte apoptosis. Multiple genetic associations between TEN and specific ethnic populations have been determined. The pathophysiology of TEN has yet to be fully elucidated; however, current pathogenic models implicate Fas ligand, granulysin, and reactive oxygen species. The value of current therapies, such as intravenous immunoglobulin and corticosteroids, remains under evaluation.
authors.affiliation: The University of Sydney, Sydney, New South Wales, Australia. adow7451@uni.sydney.edu.au
authors.forename: Andrew
authors.initials: A
authors.lastname: Downey
authors.forename: Chris
authors.initials: C
authors.lastname: Jackson
authors.forename: Nadia
authors.initials: N
authors.lastname: Harun
authors.forename: Alan
authors.initials: A
authors.lastname: Cooper
mesh_terms: D017209:Apoptosis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D010956:Plasmapheresis; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D013262:Stevens-Johnson Syndrome / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D017382:Reactive Oxygen Species