title: [Autoimmunological pulmonary alveolar proteinosis--case report].
abstract: Autoimmunological pulmonary alveolar proteinosis (APAP) is a rare interstitial lung disease with abnormal surfactant homeostasis. Autoimmunological pulmonary alveolar proteinosis is diagnosed most often in the third or fourth decade of life. Predominant symptoms are dyspnea and cough. In most cases, disease is mild but in more severe cases when dyspnea limits patient physical activity a treatment is required. The most common treatment procedure is a whole-lung lavage. We present a case study of 37 years old woman with the patchy consolidations in the chest radiograph. High resolution computed tomography (HRCT) image suggested hipersensivity pneumonitis. At the beginning due to limited disease symptoms no specific proceedings was implemented. After two year follow-up of non-resolving pulmonary changes the decision about open lung biopsy was made. On the basis of histological examination of samples and presence of anty GM-CSF antibodies the diagnosis of autoimmunological pulmonary alveolar proteinosis was established.
authors.affiliation: II Klinika Chorób Płuc, Instytut Gruźlicy i Chorób Płuc w Warszawie, ul. Płocka 26, 01-138 Warszawa. a.stoklosa@igichp.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Stokłosa
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Radzikowska
authors.forename: Inga
authors.initials: I
authors.lastname: Barańska
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.forename: Adam
authors.initials: A
authors.lastname: Nowiński
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kamiński
authors.forename: Dorota
authors.initials: D
authors.lastname: Górecka
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001706:Biopsy; D018893:Bronchoalveolar Lavage; D004417:Dyspnea / Q000209:etiology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor