title: Practical synthesis of β-oxo benzo[d]thiazolyl sulfones: scope and limitations.
abstract: In this paper, we discuss our new synthetic approach towards functionalized benzo[d]thiazolyl (BT) sulfones, based on the reunion of alkyl BT sulfones and various electrophiles (e.g. R-CO-X, RO-CO-X, RS-CO-X, Ts-X…). All important aspects of this coupling reaction, including relevant and undesirable side reactions, are evaluated by means of calculations and competitive experiments. The scope and limitations of this method are established.
authors.affiliation: Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1 box L4.01.02, B-1348, Louvain-la-Neuve, Belgium. jiri.pospisil@uclouvain.be
authors.forename: Jiří
authors.initials: J
authors.lastname: Pospíšil
authors.forename: Raphaël
authors.initials: R
authors.lastname: Robiette
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Kevin
authors.initials: K
authors.lastname: Debrus
mesh_terms: D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013450:Sulfones