title: Maggot therapy for wound debridement: a randomized multicenter trial.
abstract: OBJECTIVE
  To study the efficacy of bagged larvae on wound debridement compared with conventional treatment.
  
  
  METHODS
  Randomized, multicenter, controlled, prospective phase 3 trial with blinded assessment of outcome measures by a single observer.
  
  
  METHODS
  Two hospital referral centers in Caen and Lyon, France.
  
  
  METHODS
  Random sampling of 119 patients with a nonhealing, sloughy wound 40 cm(2) or smaller, less than 2 cm deep, and an ankle brachial index of 0.8 or higher.
  
  
  METHODS
  During a 2-week hospital stay, patients received either maggot debridement therapy (MDT) or conventional treatment. At discharge, conventional dressings were applied and a follow-up visit occurred at day 30.
  
  
  METHODS
  Percentage of slough in wounds at day 15.
  
  
  RESULTS
  There was a significant difference between groups at day 8 (54.5% in the MDT group and 66.5% in the control group) (P = .04). The mean percentage of slough at day 15 was 55.4% in the MDT group and 53.8% in the control group (P = .78).
  
  
  CONCLUSIONS
  Although MDT shows no significant benefit at day 15 compared with conventional treatment, debridement by MDT is significantly faster and occurs during the first week of treatment. Because there is no benefit in continuing the treatment after 1 week, another type of dressing should be used after 2 or 3 applications of MDT.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT01211236.
authors.affiliation: Department of Dermatology, Université de Caen Basse-Normandie, Centre Hospitalier Universitaire de Caen, Caen, France.
authors.forename: Kristina
authors.initials: K
authors.lastname: Opletalová
authors.forename: Xavier
authors.initials: X
authors.lastname: Blaizot
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Mourgeon
authors.forename: Yannick
authors.initials: Y
authors.lastname: Chêne
authors.forename: Christian
authors.initials: C
authors.lastname: Creveuil
authors.forename: Patrick
authors.initials: P
authors.lastname: Combemale
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Laplaud
authors.forename: Ingrid
authors.initials: I
authors.lastname: Sohyer-Lebreuilly
authors.forename: Anne
authors.initials: A
authors.lastname: Dompmartin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D055109:Ankle Brachial Index; D016009:Chi-Square Distribution; D003646:Debridement / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D007814:Larva; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa; D016037:Single-Blind Method; D013203:Staphylococcal Infections; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D014947:Wounds and Injuries / Q000382:microbiology / Q000628:therapy*