title: Thrombosis in children.
abstract: Thrombosis in children is becoming more prevalent due to increased awareness of these issues in the pediatric population and advances in medicine. Management of affected children are challenging due to differences in their hemostatic system compared with adults. Prospective, controlled trials for management/treatment of children with thrombosis are lacking. Many of the available guidelines for treatment of thrombosis in children are extrapolated from adult data and do not account for the uniqueness of the pediatric hemostatic system, although more research and data are becoming available. This review will focus on children over 1 year of age, including adolescents, looking at the etiology of thrombosis, diagnosis, management options, and any associated complications in this pediatric population.
authors.affiliation: Department of Paediatric Haematology, Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, United Kingdom. christine.macartney@belfasttrust.hscni.net
authors.forename: Christine A
authors.initials: CA
authors.lastname: Macartney
authors.forename: Anthony K C
authors.initials: AK
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006487:Hemostasis; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007084:Iliac Vein / Q000002:abnormalities; D007223:Infant; D011516:Prothrombin / Q000235:genetics; D011655:Pulmonary Embolism / Q000175:diagnosis; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D020246:Venous Thrombosis / Q000175:diagnosis / Q000235:genetics; D014812:Vitamin K / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D014812:Vitamin K; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin; D006493:Heparin