title: Histidine kinases and response regulators in networks.
abstract: Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how accessory proteins are employed by HKs and RRs to mediate signal integration, scaffolding, interconnection and allosteric regulation, and how these two components are embedded in regulatory networks.
authors.affiliation: Munich Center for integrated Protein Science at the Ludwig-Maximilians-Universität München, Department of Biology I, Microbiology, Großhaderner Str. 2-4, 82152 Martinsried, Germany. jung@lmu.de
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jung
authors.forename: Luitpold
authors.initials: L
authors.lastname: Fried
authors.forename: Stefan
authors.initials: S
authors.lastname: Behr
authors.forename: Ralf
authors.initials: R
authors.lastname: Heermann
mesh_terms: D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D000071677:Histidine Kinase; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D011494:Protein Kinases; D000071677:Histidine Kinase