title: Synthesis and antitumor activity of dehydroepiandrosterone derivatives on Es-2, A549, and HepG2 cells in vitro.
abstract: A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Xue-Kun
authors.initials: XK
authors.lastname: Liu
authors.forename: Bai-Jun
authors.initials: BJ
authors.lastname: Ye
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ji-Xing
authors.initials: JX
authors.lastname: Nan
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Lin
authors.forename: Hu-Ri
authors.initials: HR
authors.lastname: Piao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003687:Dehydroepiandrosterone