title: Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common cause of infertility, especially in the morbidly obese. We evaluated the long-term effects of Roux-en-Y gastric bypass on PCOS and infertility.
  
  
  METHODS
  A total of 566 morbidly obese women underwent Roux-en-Y gastric bypass from 2000 to 2009. A total of 31 patients (5.5%) had a history of PCOS. Of the 31 patients, 6 were postmenopausal and 5 lost to follow-up and were excluded. Telephone interviews were conducted with the 20 eligible patients.
  
  
  RESULTS
  The mean age and body mass index was 32 ± 5.8 years (range 22-42) and 52.8 ± 9.08 kg/m(2) (range 37-76) before surgery. All 20 patients had ≥ 2 of 3 diagnostic criteria for PCOS, including clinical or biochemical evidence of hyperandrogenism, anovulation, or polycystic ovaries. Of these, 85% had oligomenorrhea, 70% had hirsutism, and 45% had type 2 diabetes mellitus with medication. Before surgery, 8 patients conceived with or without hormonal treatment, 2 did not desire pregnancy, and 10 did not conceive. The mean follow-up was 46.7 months. After surgical weight loss, menstruation was corrected in 82%, hirsutism had resolved in 29%, and 77.8% of those with diabetes had complete remission. Of the 10 patients who did not conceive before surgery, 4 no longer desired pregnancy, and the remaining 6 patients had become pregnant within 3 years of surgery-5 without any hormonal treatment and 1 with in utero insemination.
  
  
  CONCLUSIONS
  Surgical weight loss after Roux-en-Y gastric bypass achieves excellent amelioration of PCOS manifestations and the postoperative conception rate in infertile PCOS subjects desiring pregnancy was 100%.
authors.affiliation: Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Jamal
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Gunay
authors.forename: Alyssa
authors.initials: A
authors.lastname: Capper
authors.forename: Anas
authors.initials: A
authors.lastname: Eid
authors.forename: Debi
authors.initials: D
authors.lastname: Heitshusen
authors.forename: Isaac
authors.initials: I
authors.lastname: Samuel
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007247:Infertility, Female / Q000601:surgery*; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000601:surgery*; D016742:Preconception Care / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult