title: Aspirin and immune system.
abstract: The time-tested gradual exploration of aspirin's diverse pharmacological properties has made it the most reliable therapeutic agent worldwide. In addition to its well-argued anti-inflammatory effects, many new and exciting data have emerged regarding the role of aspirin in cells of the immune system and certain immunopathological states. For instance, aspirin induces tolerogenic activity in dendritic cells and determines the fate of naive T cells to regulatory phenotypes, which suggests its immunoregulatory potential in relevance to immune tolerance. It also displays some intriguing traits to modulate the innate and adaptive immune responses. In this article, the immunomodulatory relation of aspirin to different immune cells, such as neutrophils, macrophages, dendritic cells (DCs), natural killer (NK) cells, and the T and B lymphocytes has been highlighted. Moreover, the clinical prospects of aspirin in terms of autoimmunity, allograft rejection and immune tolerance have also been outlined.
authors.affiliation: Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
authors.forename: Muzammal
authors.initials: M
authors.lastname: Hussain
authors.forename: Aqeel
authors.initials: A
authors.lastname: Javeed
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Muhammad Mahmood
authors.initials: MM
authors.lastname: Mukhtar
authors.forename: Muti Ur
authors.initials: MU
authors.lastname: Rehman
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007155:Immunologic Factors; D001241:Aspirin