title: Arterial stiffness and stroke in sickle cell disease.
abstract: OBJECTIVE
  Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke.
  
  
  METHODS
  Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured.
  
  
  RESULTS
  Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (P<0.05) and especially in patients with stroke (P<0.05).
  
  
  CONCLUSIONS
  These data suggest that transcranial Doppler and arterial stiffness might be associated to stroke in adult patients with sickle cell disease.
authors.affiliation: Internal Medicine, University Hospital, 4 rue Larrey, 49000 Angers, France. cristina.belizna@wanadoo.fr
authors.forename: Cristina
authors.initials: C
authors.lastname: Belizna
authors.forename: Laurent
authors.initials: L
authors.lastname: Loufrani
authors.forename: Alaa
authors.initials: A
authors.lastname: Ghali
authors.forename: Agnes
authors.initials: A
authors.lastname: Lahary
authors.forename: Etienne
authors.initials: E
authors.lastname: Primard
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Louvel
authors.forename: Daniel
authors.initials: D
authors.lastname: Henrion
authors.forename: Hervé
authors.initials: H
authors.lastname: Lévesque
authors.forename: Norbert
authors.initials: N
authors.lastname: Ifrah
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D020521:Stroke / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D059289:Vascular Stiffness