title: Antihypertensive therapy versus alternative therapeutic options for prehypertension: an evidence-based approach.
abstract: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) defines hypertension as systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥90 mmHg. The JNC-7 defines 'prehypertension' to include systolic BP values between 120 and 139 mmHg and diastolic BP values between 80 and 89 mmHg. Individuals with blood pressure in the prehypertension range are clearly at increased risk of developing hypertension in the future and have an increased risk of cardiovascular morbidity and mortality, compared with those with normal BP. However, there is paucity of evidence to intervene in these patients. In this article we discuss an evidence-based approach to therapeutic options in patients with prehypertension.
authors.affiliation: Department of Cardiovascular Diseases, John Ochsner Heart & Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Hwy, New Orleans, LA, USA.
authors.forename: Krishna K
authors.initials: KK
authors.lastname: Gaddam
authors.forename: Hector
authors.initials: H
authors.lastname: Ventura
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Lavie
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D003971:Diastole; D004032:Diet; D018450:Disease Progression; D019317:Evidence-Based Medicine; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D009752:Nutritional Status; D058246:Prehypertension / Q000145:classification / Q000188:drug therapy* / Q000453:epidemiology; D011322:Primary Prevention; D012307:Risk Factors; D013599:Systole; D014481:United States / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents