title: Receptor antibodies as novel therapeutics for diabetes.
abstract: Antibodies to receptors can block or mimic hormone action. Taking advantage of receptor isoforms, co-receptors, and other receptor modulating proteins, antibodies and other designer ligands can enhance tissue specificity and provide new approaches to the therapy of diabetes and other diseases.
authors.affiliation: Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Ussar
authors.forename: Sara G
authors.initials: SG
authors.lastname: Vienberg
authors.forename: C Ronald
authors.initials: CR
authors.lastname: Kahn
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D008297:Male; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D051496:Receptor, Fibroblast Growth Factor, Type 1