title: [A case of lung injury induced by long-term administration of mesalazine].
abstract: A 52-year-old man was given a diagnosis of ulcerative colitis and treated with mesalazine for 7.5 years. However, the unusually long administration of mesalazine induced lung injury and the patient complained of a dry cough and dyspnea on limited exertion. Infiltrative shadows were observed in bilateral lung fields on a chest radiograph and computed tomographic images. The histological findings obtained by transbronchial biopsy and bronchoalveolar lavage showed organizing pneumonia. His drug-induced lymphocyte stimulation test (DLST) for mesalazine was positive. Improvements in his clinical symptoms and radiographic abnormalities occurred spontaneously after the discontinuation of mesalazine. This case indicates that the long-term administration of mesalazine may lead to an adverse pulmonary reaction.
authors.affiliation: Department of Respiratory Medicine, Sendai City Medical Center.
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Shindoh
authors.forename: Ryo
authors.initials: R
authors.lastname: Horaguchi
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Suda
authors.forename: Hideya
authors.initials: H
authors.lastname: Iijima
authors.forename: Chiyohiko
authors.initials: C
authors.lastname: Shindoh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine