title: Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds.
abstract: Use of herbal plant remedies to treat infectious diseases is a common practice in many countries in traditional and alternative medicine. However to date there are only few antimicrobial agents derived from botanics. Based on microbiological screening tests of crude plant extracts we identified four compounds derived from Krameria, Aesculus hippocastanum and Chelidonium majus that showed a potentially interesting antimicrobial activity. In this work we present an in depth characterization of the inhibition activity of these pure compounds on the formation of biofilm of Staphylococcus aureus as well as of Staphylococcus epidermidis strains. We show that two of these compounds possess interesting potential to become active principles of new drugs.
authors.affiliation: Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Artini
authors.forename: R
authors.initials: R
authors.lastname: Papa
authors.forename: G
authors.initials: G
authors.lastname: Barbato
authors.forename: G L
authors.initials: GL
authors.lastname: Scoarughi
authors.forename: A
authors.initials: A
authors.lastname: Cellini
authors.forename: P
authors.initials: P
authors.lastname: Morazzoni
authors.forename: E
authors.initials: E
authors.lastname: Bombardelli
authors.forename: L
authors.initials: L
authors.lastname: Selan
mesh_terms: D031319:Aesculus / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D028281:Chelidonium / Q000737:chemistry; D031326:Krameriaceae / Q000737:chemistry; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000502:physiology*; D013212:Staphylococcus epidermidis / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D008565:Membrane Proteins; D010936:Plant Extracts