title: Comparison of ocular comfort, vision, and SICS during silicone hydrogel contact lens daily wear.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between solution-induced corneal staining (SICS) and silicone hydrogel contact lens comfort and vision.
  
  
  METHODS
  A retrospective analysis of a series of open-label studies were conducted with 24 groups of approximately 40 participants, each wearing 1 of 6 silicone hydrogel contact lenses with 1 of 4 lens care products bilaterally for 3 months of daily wear. The presence of SICS and subjective ocular ratings were collected at 2 weeks and at 1 and 3 months.
  
  
  RESULTS
  A total of 1,051 participants were enrolled. The participants with SICS rated significantly less favorably than did the participants without SICS for comfort during the day (7.9±1.7 vs. 8.5±1.4, P=0.03), comfort at the end of the day (6.6±2.1 vs. 7.4±1.9, P=0.03), overall dryness (7.4±1.9 vs. 8.0±1.7, P=0.04), dryness at the end of the day (6.7±2.2 vs. 7.5±2.1, P=0.01), feelings of burning and stinging (8.5±2.0 vs. 8.9±1.8, P=0.02), and overall vision (8.2±1.6 vs. 8.7±1.3, P<0.001).
  
  
  CONCLUSIONS
  The participants with SICS had lower subjective comfort and vision compared with those who did not experience SICS.
authors.affiliation: Brien Holden Vision Institute, Sydney, NSW, Australia. j.diec@brienholdenvision.org
authors.forename: Jennie
authors.initials: J
authors.lastname: Diec
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Evans
authors.forename: Daniel
authors.initials: D
authors.lastname: Tilia
authors.forename: Thomas
authors.initials: T
authors.lastname: Naduvilath
authors.forename: Brien A
authors.initials: BA
authors.lastname: Holden
authors.forename: Percy
authors.initials: P
authors.lastname: Lazon de la Jara
mesh_terms: D000328:Adult; D018639:Contact Lens Solutions / Q000494:pharmacology*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D015352:Dry Eye Syndromes / Q000209:etiology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D017060:Patient Satisfaction; D012030:Refractive Errors / Q000628:therapy; D012189:Retrospective Studies; D012828:Silicones; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D018639:Contact Lens Solutions; D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate