title: A mammalian like interleukin-1 receptor-associated kinase 4 (IRAK-4), a TIR signaling mediator in intestinal innate immunity of black tiger shrimp (Penaeus monodon).
abstract: Interleukin-1 receptor associated kinase-4 (IRAK-4) has been identified as a central signal transduction mediator of the Toll-like receptor (TLR) and Toll/interleukin-1 receptor (TIR) pathways in vertebrate innate immunity. An IRAK-4 homologue was cloned from the black tiger shrimp (Penaeus monodon) (PmIRAK-4) and it shares domains and structures with other IRAK-4s. It was found to be mainly expressed in the hemocytes and midgut but also to a lower extent in several other tissues in shrimp. The PmIRAK-4 responded to bacterial infection in the intestine by an enhancement of its expression level. These results indicate that PmIRAK-4 may play a role at least in the intestinal innate immunity of P. monodon.
authors.affiliation: Department of Comparative Physiology, Uppsala University, Uppsala, Sweden.
authors.forename: Apiruck
authors.initials: A
authors.lastname: Watthanasurorot
authors.forename: Kenneth
authors.initials: K
authors.lastname: Söderhäll
authors.forename: Pikul
authors.initials: P
authors.lastname: Jiravanichpaisal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D007113:Immunity, Innate; D053592:Interleukin-1 Receptor-Associated Kinases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D033561:Penaeidae / Q000201:enzymology / Q000276:immunology*; D010802:Phylogeny; D017433:Protein Structure, Secondary; D051193:Toll-Like Receptors / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D051193:Toll-Like Receptors; D053592:Interleukin-1 Receptor-Associated Kinases