title: Lessons from yeast for clathrin-mediated endocytosis.
abstract: Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
authors.affiliation: Department of Molecular and Cellular Pharmacology (R-189), Miller School of Medicine, University of Miami, Miami, Florida 33101, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Boettner
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Chi
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Lemmon
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins