title: Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients.
abstract: OBJECTIVE
  To investigate the usage of a high-density EEG recording system and source imaging technique for localizing seizure activity in patients with medically intractable partial epilepsy.
  
  
  METHODS
  High-density, 76-channel scalp EEG signals were recorded in 10 patients with partial epilepsy. The patients underwent routine clinical pre-surgical evaluation and all had resective surgery with seizure free outcome. After applying a FINE (first principle vectors) spatio-temporal source localization and DTF (directed transfer function) connectivity analysis approach, ictal sources were imaged. Effects of number of scalp EEG electrodes on the seizure localization were also assessed using 76, 64, 48, 32, and 21 electrodes, respectively.
  
  
  RESULTS
  Surgical resections were used to assess the source imaging results. Results from the 76-channel EEG in the 10 patients showed high correlation with the surgically resected brain regions. The localization of seizure onset zone from 76-channel EEG showed improved source detection accuracy compared to other EEG configurations with fewer electrodes.
  
  
  CONCLUSIONS
  FINE together with DTF was able to localize seizure onset zones of partial epilepsy patients. High-density EEG recording can help achieve improved seizure source imaging.
  
  
  CONCLUSIONS
  The present results suggest the promise of high-density EEG and electrical source imaging for noninvasively localizing seizure onset zones.
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Worrell
authors.forename: Bin
authors.initials: B
authors.lastname: He
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D004566:Electrodes; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D004828:Epilepsies, Partial / Q000473:pathology* / Q000503:physiopathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged