title: [The choice of the targets and the search for their inhibitors by means of computer simulation for the development of innovative preparations to treat of chronic bacterial infections].
abstract: Persistence is a form of interaction of pathogenic bacteria with a host aimed to promote their long-term survivalby means of inactivation of the host's protective systems via modulation of intracellular signal pathways. Persistent forms of a pathogen are refractory to traditional antibiotic therapy and cause chronic infectious diseases. Directed search for protein targets and new antibacterial drugs using computer simulation and experimental testing for the development of innovative preparations to treat chronic bacterial infections appears to have good prospects as a method for the management of persistent infections. A stepwise strategy for realization of such approach is exemplified by the search of preparations against chlamydial infection.
authors.forename: A S
authors.initials: AS
authors.lastname: Kariagina
authors.forename: N A
authors.initials: NA
authors.lastname: Zigangirova
authors.forename: A V
authors.initials: AV
authors.lastname: Grishin
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Davydova
authors.forename: M S
authors.initials: MS
authors.lastname: Krivozubov
authors.forename: D D
authors.initials: DD
authors.lastname: Kirsanov
authors.forename: E S
authors.initials: ES
authors.lastname: Zaiakin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001426:Bacterial Proteins / Q000378:metabolism; D002689:Chlamydia / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D002908:Chronic Disease; D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D037521:Virulence Factors