title: The structure of allelic diversity in the presence of purifying selection.
abstract: In the absence of selection, the structure of equilibrium allelic diversity is described by the elegant sampling formula of Ewens. This formula has helped to shape our expectations of empirical patterns of molecular variation. Along with coalescent theory, it provides statistical techniques for rejecting the null model of neutrality. However, we still do not fully understand the statistics of the allelic diversity expected in the presence of natural selection. Earlier work has described the effects of strongly deleterious mutations linked to many neutral sites, and allelic variation in models where offspring fitness is unrelated to parental fitness, but it has proven difficult to understand allelic diversity in the presence of purifying selection at many linked sites. Here, we study the population genetics of infinitely many perfectly linked sites, some neutral and some deleterious. Our approach is based on studying the lineage structure within each class of individuals of similar fitness in the deleterious mutation-selection balance. Consistent with previous observations, we find that for moderate and weak selection pressures, the patterns of allelic diversity cannot be described by a neutral model for any choice of the effective population site. We compute precisely how purifying selection at many linked sites distorts the patterns of allelic diversity, by developing expressions for the likelihood of any configuration of allelic types in a sample analogous to the Ewens sampling formula.
authors.affiliation: Department of Organismic and Evolutionary Biology, Harvard University, United States.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Desai
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Nicolaisen
authors.forename: Aleksandra M
authors.initials: AM
authors.lastname: Walczak
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Plotkin
mesh_terms: D000483:Alleles; D056084:Genetic Fitness / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D010809:Physical Fitness; D016012:Poisson Distribution; D011157:Population Dynamics; D011336:Probability