title: Conjugated linoleic acid combined with physical activity reduces body fat accumulation but does not modify lean body mass in male and female Wistar rats.
abstract: Several biological and clinical studies have suggested that conjugated linoleic acid (CLA) prevents body fat accumulation and increases lean body mass. CLA is available as a concentrated dietary supplement and is purported to provide the aforementioned benefits for people who perform physical activity. This study was conducted to evaluate the effect of a CLA-supplemented diet combined with physical activity on the body composition of Wistar rats. Two groups of Wistar rats of both sexes, between 45 and 60 days old, were fed a diet containing 5.5% soybean oil (control group) or a CLA-supplemented diet (0.5% CLA and 5.0% soybean oil) (test group). Half the rats in both groups were assigned to exercise by running on a treadmill. The biochemical and anatomical body compositions were analyzed. In both groups, CLA had no effect on the dietary consumption or the weight of the liver, heart, and lungs. However, it did influence the overall weight gain of exercised male rats and the chemical and anatomical body composition in exercised and sedentary rats of both sexes. The results confirm that a CLA-supplemented diet with and without physical activity reduced body fat accumulation in rats of both sexes. However, there is no evidence of an increase in the lean body mass of the exercised rats.
authors.affiliation: Department of Agroindustry, Food and Nutrition, University of São Paulo, Piracicaba, São Paulo, Brazil. jmsalgad@esalq.usp.br
authors.forename: Jocelem Mastrodi
authors.initials: JM
authors.lastname: Salgado
authors.forename: Tânia Rachel Baroni
authors.initials: TR
authors.lastname: Ferreira
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Donado-Pestana
authors.forename: Omer Cavalcanti
authors.initials: OC
authors.lastname: de Almeida
authors.forename: Aline Mouro Ribeiro
authors.initials: AM
authors.lastname: das Neves
authors.forename: Débora Niero
authors.initials: DN
authors.lastname: Mansi
authors.forename: Carlos Tadeu Dos Santos
authors.initials: CT
authors.lastname: Dias
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D006321:Heart / Q000187:drug effects; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D009043:Motor Activity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000008:administration & dosage; D015430:Weight Gain / Q000187:drug effects
chemical_list: D044243:Linoleic Acids, Conjugated; D013024:Soybean Oil