title: Association between paraoxonase 2 Ser311Cys polymorphism and ischemic stroke risk: a meta-analysis involving 5,008 subjects.
abstract: Epidemiological studies have evaluated the association between paraoxonase 2 (PON2) Ser311Cys polymorphism and ischemic stroke risk which developed inconsistent conclusions. The aim of this study was to perform a meta-analysis to investigate a more authentic association between PON2 Ser311Cys polymorphism and ischemic stroke. Systematic searches in PUBMED, EMBASE, CBM, and CNKI databases were performed. Data analyses were carried out by Review Manager 5.1.2 and Stata 11.0. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used for additive model (Cys/Cys vs. Ser/Ser), dominant model (Ser/Cys+Cys/Cys vs. Ser/Ser), recessive model (Cys/Cys vs. Ser/Cys+Ser/Ser), and allelic model (Cys allele vs. Ser allele), respectively. Publication bias was analyzed by Begg's funnel plot and Egger's test. A total of 7 studies including 2,046 cases and 2,962 controls were involved. Overall, no significant association was found between PON2 Ser311Cys polymorphism and ischemic stroke risk when all studies were pooled into the meta-analysis (for additive model: OR = 0.87, 95% CI = 0.67-1.14; for dominant model: OR = 1.05, 95% CI = 0.91-1.22; for recessive model: OR = 0.90, 95% CI = 0.77-1.05; and for allelic model: OR = 1.17, 95% CI = 0.86-1.59). In the subgroup analysis by ethnicity, significant association was found among Europeans (for recessive model: OR = 0.83, 95% CI = 0.69-0.99). However, due to the small number of studies included in subgroup analysis, the result for European population should be interpreted cautiously.
authors.affiliation: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, People's Republic of China.
authors.forename: Bing-Hu
authors.initials: BH
authors.lastname: Li
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Pi
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Yang
authors.forename: Chang-Yue
authors.initials: CY
authors.lastname: Gao
authors.forename: Chuan-Qin
authors.initials: CQ
authors.lastname: Fang
authors.forename: Jing-Zhou
authors.initials: JZ
authors.lastname: Wang
authors.forename: Jing-Cheng
authors.initials: JC
authors.lastname: Li
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008954:Models, Biological; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D015203:Reproducibility of Results; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000201:enzymology* / Q000235:genetics*
chemical_list: D043303:Aryldialkylphosphatase; C468411:PON2 protein, human