title: mTOR regulates T-cell differentiation and activation in immunity and autoimmunity.
abstract: mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, the kinase mTOR has emerged as an important regulator of the differentiation and function of helper T cells in immune responses and autoimmune diseases. In this review, we summarize the regulatory effects and mechanisms of mTOR complex in the differentiation of CD4+ T and CD8+ T cells, and T-cell homeostasis modulation. This should contribute to understanding the central role for mTOR in regulating immune responses and autoimmune diseases.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Bi
authors.forename: Guangwei
authors.initials: G
authors.lastname: Liu
authors.forename: Ruifu
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases