title: Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis.
abstract: OBJECTIVE
  In this review, we discuss the mechanisms behind the binding of low-density lipoproteins (LDL) to the arterial wall and how this interaction might be targeted to prevent atherosclerosis.
  
  
  RESULTS
  An increasing body of evidence shows that accumulation of LDL in the vessel wall is a critical step in the development of atherosclerosis. The retained lipoproteins subsequently provoke an inflammatory response that ultimately leads to atherosclerosis. In the arterial wall, LDL binds ionically to proteoglycans in the extracellular matrix. In particular, proteoglycans with elongated glycosaminoglycan (GAG) chains seem to play a crucial role in this process.
  
  
  CONCLUSIONS
  The LDL-proteoglycan interaction is a highly regulated process that might provide new therapeutic targets against cardiovascular disease.
authors.affiliation: Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, 41345 Gothenburg, Sweden. perf@wlab.gu.se
authors.forename: P
authors.initials: P
authors.lastname: Fogelstrand
authors.forename: J
authors.initials: J
authors.lastname: Borén
mesh_terms: D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001055:Apolipoproteins B / Q000378:metabolism*; D001161:Arteriosclerosis / Q000517:prevention & control; D050197:Atherosclerosis; D005109:Extracellular Matrix / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D012307:Risk Factors
chemical_list: D001055:Apolipoproteins B; D006025:Glycosaminoglycans; D008077:Lipoproteins, LDL; D011509:Proteoglycans