title: Relationship between reproductive history, anthropometrics, lifestyle factors, and the likelihood of persistent chemotherapy-related amenorrhea in women with premenopausal breast cancer.
abstract: OBJECTIVE
  To determine the association between patient characteristics at diagnosis of premenopausal breast cancer, including gravidity, parity, age at menarche, age at first birth, alcohol use, smoking history, weight, height, and body mass index (BMI), with the development of persistent chemotherapy-related amenorrhea (CRA) in follow-up.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Dana Farber Cancer Institute and Brigham and Women's Hospital.
  
  
  METHODS
  Premenopausal women with breast cancer.
  
  
  METHODS
  We identified all premenopausal women who received standard adjuvant chemotherapy during 1997-2005 for whom menstrual data were available. Multivariable logistic regression models evaluating persistent amenorrhea at ≥6 month after completion of chemotherapy were conducted.
  
  
  METHODS
  Persistent chemotherapy-related amenorrhea (CRA) at ≥6 months from completion of chemotherapy.
  
  
  RESULTS
  A total of 431 women met eligibility criteria and had ≥6-months' follow-up. Women with older (>13 years) vs. younger (12-13 years) age at menarche were more than twice as likely to remain amenorrheic. Current smokers had 2.4 greater odds of CRA vs. never smokers, although this association was not statistically significant (95% confidence interval, 0.86-6.75).
  
  
  CONCLUSIONS
  Few identifiable factors contribute to the variability in CRA among premenopausal women after adjuvant chemotherapy for breast cancer. Further research to improve the prediction of CRA, premature menopause, and infertility in young breast cancer survivors is warranted.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. maskelya@msn.com
authors.forename: Mary E
authors.initials: ME
authors.lastname: Abusief
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Missmer
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Ginsburg
authors.forename: Jane C
authors.initials: JC
authors.lastname: Weeks
authors.forename: Ann H
authors.initials: AH
authors.lastname: Partridge
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D000568:Amenorrhea / Q000139:chemically induced* / Q000453:epidemiology*; D000886:Anthropometry; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008572:Menarche; D008875:Middle Aged; D010298:Parity; D011237:Predictive Value of Tests; D011247:Pregnancy; D017697:Premenopause; D012098:Reproduction; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents