title: Varenicline precipitating psychosis in a patient with no previous psychiatric history: a case report of a Spanish patient who was later diagnosed with paranoid personality disorder.
abstract: Varenicline is gaining popularity for the treatment of nicotine dependence. General treatment guidelines recommend monitoring for behavioral changes in patients with a mental illness. There are very few cases reported on patients developing psychiatric symptoms with no previous history. We are reporting the case of a Spanish patient who had developed a first-psychotic episode after he was started on varenicline. He was ultimately diagnosed with a paranoid personality disorder. Therefore, prior to starting a patient on varenicline, the clinician must identify possible paranoid and other cluster A personality traits. It is essential to monitor for new onset of psychotic symptoms during the treatment with this drug.
authors.affiliation: MetroHealth Medical Center-Psychiatry, Cleveland, OH 44109, USA. fespiforcen@metrohealth.org
authors.forename: Fernando Espi
authors.initials: FE
authors.lastname: Forcen
authors.forename: Fernando Luis Espi
authors.initials: FL
authors.lastname: Martinez
authors.forename: Amparo Martinez
authors.initials: AM
authors.lastname: Moya
mesh_terms: D001552:Benzazepines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000009:adverse effects*; D010260:Paranoid Personality Disorder / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000150:complications* / Q000523:psychology; D011810:Quinoxalines / Q000009:adverse effects*; D016540:Smoking Cessation / Q000379:methods*; D013030:Spain; D061485:Tobacco Use Cessation Devices / Q000009:adverse effects*; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline