title: Inside the complex regulation of Pseudomonas aeruginosa chaperone usher systems.
abstract: Pseudomonas aeruginosa assembles several cell surface-associated organelles, including those of the chaperone usher (CU) pathway. Five different CU loci have been identified and characterized in various strains of P.aeruginosa. However, their potential functional redundancy, particularly in biofilm formation, is supported by the control of their expression by a complex and specific regulatory network. Here, we review recent findings relating to this network. The control exerted by this network involves transcriptional repressors and activators, a phase-variable mechanism, a second intracellular messenger (c-di-GMP) and chemosensory and two-component systems.
authors.affiliation: Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS - Aix Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Giraud
authors.forename: Sophie
authors.initials: S
authors.lastname: de Bentzmann
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms; D015964:Gene Expression Regulation, Bacterial; D018832:Molecular Chaperones / Q000378:metabolism*; D005810:Multigene Family; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones