title: Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers.
abstract: Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which patients may be appropriately stratified in such clinical trials.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hobson
authors.forename: Hector R
authors.initials: HR
authors.lastname: Wong
mesh_terms: D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D007167:Immunotherapy / Q000379:methods*; D007371:Interferon-gamma / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D012333:RNA, Messenger / Q000097:blood*; D012772:Shock, Septic / Q000628:therapy*
chemical_list: D008070:Lipopolysaccharides; D012333:RNA, Messenger; D007371:Interferon-gamma