title: Life and death of lymphocytes: a volume regulation affair.
abstract: The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.
authors.affiliation: The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
authors.forename: Carl D
authors.initials: CD
authors.lastname: Bortner
authors.forename: John A
authors.initials: JA
authors.lastname: Cidlowski
mesh_terms: D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D048429:Cell Size; D053938:DNA Fragmentation; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D009997:Osmotic Pressure
chemical_list: D020169:Caspases