title: Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy.
abstract: Calcineurin inhibitors (CNI) have been clearly associated with posttransplant thrombotic microangiopathy (PTTMA). We report a case of de novo PT-TMA involving predominantly small arteries and arterioles of a renal allograft in a patient receiving tacrolimus. Serial biopsies demonstrate the natural history of this lesion through the chronic nonspecific phase. The case is discussed in the context of a literature review of PT-TMA in general and CNI use in particular.
authors.affiliation: Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA , USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Carson
authors.forename: Eric D
authors.initials: ED
authors.lastname: Newman
authors.forename: John L
authors.initials: JL
authors.lastname: Farber
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Filippone
mesh_terms: D000208:Acute Disease; D000368:Aged; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000009:adverse effects*; D057049:Thrombotic Microangiopathies / Q000139:chemically induced* / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus