title: pH-responsive drug delivery system based on luminescent CaF(2):Ce(3+)/Tb(3+)-poly(acrylic acid) hybrid microspheres.
abstract: In this study, we design a controlled release system based on CaF(2):Ce(3+)/Tb(3+)-poly(acrylic acid) (PAA) composite microspheres, which were fabricated by filling the pH-responsive PAA inside CaF(2):Ce(3+)/Tb(3+) hollow spheres via photopolymerization route. The CaF(2):Ce(3+)/Tb(3+) hollow spheres prepared by hydrothermal route possess mesoporous structure and show strong green fluorescence from Tb(3+) under UV excitation. Doxorubicin hydrochloride (DOX), a widely used anti-cancer drug, was used as a model drug to evaluate the loading and controlled release behaviors of the composite microspheres due to the good biocompatibility of the samples using MTT assay. The composite carriers provide a strongly pH-dependent drug release behavior owing to the intrinsic property of PAA and its interactions with DOX. The endocytosis process of drug-loaded microspheres was observed using confocal laser scanning microscopy (CLSM) and the in vitro cytotoxic effect against SKOV3 ovarian cancer cells of the DOX-loaded carriers was investigated. In addition, the extent of drug release could be monitored by the altering of photoluminescence (PL) intensity of CaF(2):Ce(3+)/Tb(3+). Considering the good biocompatibility, high drug loading content and pH-dependent drug release of the materials, these hybrid luminescent microspheres have potential applications in drug controlled release and disease therapy.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Cuimiao
authors.initials: C
authors.lastname: Zhang
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Kang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000042:Absorption / Q000187:drug effects; D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D002124:Calcium Fluoride / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002586:Cesium / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D049449:Luminescence; D051379:Mice; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013725:Terbium / Q000737:chemistry*; D013818:Thermogravimetry
chemical_list: D000180:Acrylic Resins; D013725:Terbium; D002586:Cesium; C006903:carbopol 940; D004317:Doxorubicin; D002124:Calcium Fluoride