title: Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective.
abstract: Fasciola hepatica is a food-borne parasite of animals and humans. It secretes a large family of cysteine peptidases, termed cathepsins, that are important virulence factors. Here, we discuss how advances in molecular technologies have helped to probe the function of liver fluke cathepsins, and consider how evolving systems/molecular biology approaches can continue to inform our understanding of these important parasite enzymes.
authors.affiliation: Molecular Biosciences-Parasitology, Institute of Agri-Food and Land Use, School of Biological Sciences, Queen's University Belfast, Belfast BT9 7BL, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: McVeigh
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Maule
authors.forename: John P
authors.initials: JP
authors.lastname: Dalton
authors.forename: Mark W
authors.initials: MW
authors.lastname: Robinson
mesh_terms: D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D005210:Fasciola hepatica / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity*; D020868:Gene Silencing; D023281:Genomics; D006801:Humans; D021381:Protein Transport; D040901:Proteomics; D034622:RNA Interference; D012106:Research; D059467:Transcriptome; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors; D002403:Cathepsins; D003546:Cysteine Endopeptidases