title: [A case of epiglottic NK/T cell malignant lymphoma].
abstract: We report a case of malignant epiglottic natural killer (NK)/T cell lymphoma. A 33-year-old man seen 1-month period for throat pain was found in endoscopic larynx examination to have inflammation with plaques and redness epiglottic. The 4 month period, right epiglottic inflammation showed progressive necrosis. The diagnosis of malignant lymphoma was confirmed by 3 biopsies. Laryngomicrosurgery specimens histologicalily showed moderate leukocytic infiltration mainly of atypical lymphocytes. Neoplastic cells were UHCL1+, CD3+, L26-, CD79a, and EBER-ISHW. Despite 4 units of DeVIC chemotherapy and regional irradiation, the man died of metastatis 1 year and 9 months after initial treatment. Among malignant laryngeal tumors, malignant epiglottic NK/T cell lymphoma is extremely rare, with only one case reported in the literature.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hiroshima Prefectural Hospital, Hiroshima.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Hirai
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fukushima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakashimo
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katagiri
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kubota
authors.forename: Takuya
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000328:Adult; D004825:Epiglottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male