title: Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
abstract: The elaboration of a novel scaffold for the inhibition of JAK2 and FAK kinases was targeted in order to provide a dual inhibitor that could target divergent pathways for tumor cell progression.
authors.affiliation: Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA. czificsa@cephalon.com
authors.forename: Craig A
authors.initials: CA
authors.lastname: Zificsak
authors.forename: Diane E
authors.initials: DE
authors.lastname: Gingrich
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Breslin
authors.forename: Derek D
authors.initials: DD
authors.lastname: Dunn
authors.forename: Karen L
authors.initials: KL
authors.lastname: Milkiewicz
authors.forename: Jay P
authors.initials: JP
authors.lastname: Theroff
authors.forename: Tho V
authors.initials: TV
authors.lastname: Thieu
authors.forename: Ted L
authors.initials: TL
authors.lastname: Underiner
authors.forename: Linda R
authors.initials: LR
authors.lastname: Weinberg
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Aimone
authors.forename: Mark S
authors.initials: MS
authors.lastname: Albom
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Mason
authors.forename: Lisa
authors.initials: L
authors.lastname: Saville
authors.forename: Jean
authors.initials: J
authors.lastname: Husten
authors.forename: Thelma S
authors.initials: TS
authors.lastname: Angeles
authors.forename: James P
authors.initials: JP
authors.lastname: Finn
authors.forename: Mahfuza
authors.initials: M
authors.lastname: Jan
authors.forename: Teresa M
authors.initials: TM
authors.lastname: O'Kane
authors.forename: Pawel
authors.initials: P
authors.lastname: Dobrzanski
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Dorsey
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018450:Disease Progression; D015195:Drug Design; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D053614:Janus Kinase 2 / Q000737:chemistry*; D051379:Mice; D008956:Models, Chemical; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D047428:Protein Kinase Inhibitors; D051416:Focal Adhesion Protein-Tyrosine Kinases; D053614:Janus Kinase 2