title: Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke.
abstract: OBJECTIVE
  Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume.
  
  
  METHODS
  Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generated for all subjects. The animals were sacrificed immediately following the last imaging study to measure infarct volume on histology. The reliability of FPD-CBCT-based lesion volume measurements was compared with those measured histologically by using regression and Bland-Altman analysis.
  
  
  RESULTS
  The best correlation (R(2) = 0.72) between lesion volumes assessed with FPD-CBCT and histology was established with a threshold of mean healthy CBV - 2.5 × SD. These results were inferior to the correlation of lesion volumes measured with ADC and histology (R(2) = 0.99). Bland-Altman analysis showed that the agreement of ADC-derived lesion volumes with histology was superior to the agreement of FPD-CBCT-derived lesion volumes with histology.
  
  
  CONCLUSIONS
  We correlated FPD-CBCT measurements of CBV and MR ADC lesion volumes with histologically assessed infarct volume. As expected, ADC is a very accurate and precise method for determining the extent of infarction. FPD-CBCT CBV lesion volumes are correlated to the size of the infarct. Improvement of FPD-CBCT image quality provides an opportunity to establish quantitative CBV measurement in the angiography suite.
authors.affiliation: Department of Radiology, New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
authors.forename: I M J
authors.initials: IM
authors.lastname: van der Bom
authors.forename: M
authors.initials: M
authors.lastname: Mehra
authors.forename: R P
authors.initials: RP
authors.lastname: Walvick
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chueh
authors.forename: M J
authors.initials: MJ
authors.lastname: Gounis
mesh_terms: D000818:Animals; D001810:Blood Volume; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D020521:Stroke / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed