title: Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy.
abstract: We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naïve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.
authors.affiliation: Department of Clinical Sciences L. Sacco, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy. marco.franzetti@unimi.it
authors.forename: M
authors.initials: M
authors.lastname: Franzetti
authors.forename: M
authors.initials: M
authors.lastname: Violin
authors.forename: G
authors.initials: G
authors.lastname: Casazza
authors.forename: G
authors.initials: G
authors.lastname: Meini
authors.forename: A
authors.initials: A
authors.lastname: Callegaro
authors.forename: P
authors.initials: P
authors.lastname: Corsi
authors.forename: F
authors.initials: F
authors.lastname: Maggiolo
authors.forename: A R
authors.initials: AR
authors.lastname: Pignataro
authors.forename: S
authors.initials: S
authors.lastname: Paolucci
authors.forename: N
authors.initials: N
authors.lastname: Gianotti
authors.forename: D
authors.initials: D
authors.lastname: Francisci
authors.forename: R
authors.initials: R
authors.lastname: Rossotti
authors.forename: G
authors.initials: G
authors.lastname: Filice
authors.forename: T
authors.initials: T
authors.lastname: Carli
authors.forename: M
authors.initials: M
authors.lastname: Zazzi
authors.forename: C
authors.initials: C
authors.lastname: Balotta
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents