title: Effect of cardiac resynchronization therapy on cardiotrophin-1 circulating levels in patients with heart failure.
abstract: Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines. Plasma CT-1 levels correlate with the left ventricle mass index in patients with dilatated cardiomyopathy and congestive heart failure (CHF). The aim of this paper was to evaluate CT-1 plasma levels, before and after cardiac resynchronization therapy CRT, and to characterizeits prognostic role in patients with CHF. Fifty-two consecutive patients (M/F = 39/13; 56 ± 11 years old) underwent clinical and echocardiographic evaluation, and blood sample collection at baseline. The same evaluation was repeated 6.4 ± 0.79 months after CRT. Patients with a decreased LV end-systolic volume by at least 15% (reverse remodeling) were considered echo responders to CRT. Twenty-nine patients (56%) were responders to CRT. After CRT, only 15 patients (29%) showed increased CT-1 after CRT. They were all non responders to CRT. A multivariate, logistic model showed CT-1 as an independent predictor of CRT echo response (p = 0.005; OR 0.97). During follow-up (18 ± 7 months), 21 cardiac events in 18 patients occurred. A Cox multivariable model showed plasma BNP pre-CRT (p = 0.02; CI 1.2-5.6; OR 3.1) and CT1 post-CRT (p = 0.01; CI 1.4-4.3; OR 2.7) as independent predictors of cardiac events. Analysis of CT-1 plasma levels deserves future consideration for larger, longitudinal studies in patients with CHF.
authors.affiliation: Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, Italy, limongelligiuseppe@libero.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Limongelli
authors.forename: Teo
authors.initials: T
authors.lastname: Roselli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pacileo
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabró
authors.forename: Valeria
authors.initials: V
authors.lastname: Maddaloni
authors.forename: Daniele
authors.initials: D
authors.lastname: Masarone
authors.forename: Lucia
authors.initials: L
authors.lastname: Riegler
authors.forename: Rita
authors.initials: R
authors.lastname: Gravino
authors.forename: Raffaella
authors.initials: R
authors.lastname: Scarafile
authors.forename: Gemma
authors.initials: G
authors.lastname: Salerno
authors.forename: Tiziana
authors.initials: T
authors.lastname: Miele
authors.forename: Antonello
authors.initials: A
authors.lastname: D'Andrea
authors.forename: Lucio
authors.initials: L
authors.lastname: Santangelo
authors.forename: Massimo
authors.initials: M
authors.lastname: Romano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Salvo
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Russo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabró
mesh_terms: D000328:Adult; D000368:Aged; D058406:Cardiac Resynchronization Therapy; D016207:Cytokines / Q000097:blood*; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D016207:Cytokines; C092073:cardiotrophin 1