title: Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.
abstract: To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was measured. There was correlation between serum anti-CCP and DAS28-ESR. (R (2) = 0.71, P value < 0.01). New disease activity index was developed by replacing anti-CCP with ESR in DAS28-ESR. There was correlation between new model and DAS28-ESR. (R (2) = 0.91, P value < 0.01) The new composite index best cut-off values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 3.21, 3.38, and 4.74, respectively. There was agreement between new model and DAS28-ESR for determination of patients in different disease activity categories. (Kappa = 0.71, P value < 0.01). The new disease activity index that applies serum anti-CCP may predict disease activity in RA.
authors.affiliation: Internal Medicine Ward, Division of Rheumatology, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Kamal
authors.initials: K
authors.lastname: Esalatmanesh
authors.forename: Raika
authors.initials: R
authors.lastname: Jamali
authors.forename: Arsia
authors.initials: A
authors.lastname: Jamali
authors.forename: Bardia
authors.initials: B
authors.lastname: Jamali
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Nikbakht
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide