title: Blood pressure and other metabolic syndrome factors and risk of brain tumour in the large population-based Me-Can cohort study.
abstract: OBJECTIVE
  Brain tumour has few established determinants. We assessed to which extent risk of brain tumour was related to metabolic syndrome factors in adults.
  
  
  METHODS
  In the Me-Can project, 580 000 individuals from Sweden, Austria, and Norway were followed for a median of 10 years after baseline measurement. Data on brain tumours were obtained from national cancer registries. The factors of metabolic syndrome (BMI, SBP and DBP, and blood levels of glucose, cholesterol, and triglycerides), separately and combined, were analysed in quintiles and for transformed z-scores (mean transformed to 0 and standard deviation to 1). Cox proportional hazards multivariate regression models were used, with corrections for measurement error.
  
  
  RESULTS
  During follow-up, 1312 primary brain tumours were diagnosed, predominantly meningioma (n = 348) and high-grade glioma (n = 436). For meningioma, the hazard ratio was increased for z-scores of SBP [hazard ratio = 1.27 per unit standard deviation, 95% confidence interval (CI) 1.03-1.57], of DBP (hazard ratio = 1.29, 95% CI 1.04-1.58), and of the combined metabolic syndrome score (hazard ratio = 1.31, 95% CI 1.11-1.54). An increased risk of high-grade glioma was found for DBP (hazard ratio = 1.23, 95% CI 1.01-1.50) and triglycerides (hazard ratio = 1.35, 95% CI 1.05-1.72). For both meningioma and high-grade glioma, the risk was more than double in the fifth quintiles of DBP compared to the lowest quintile. For meningioma this risk was even larger for SBP.
  
  
  CONCLUSIONS
  Increased blood pressure was associated with risk of brain tumours, especially of meningiomas.
authors.affiliation: Department of Medical Statistics, Informatics and Health Economics, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Edlinger
authors.forename: Susanne
authors.initials: S
authors.lastname: Strohmaier
authors.forename: Håkan
authors.initials: H
authors.lastname: Jonsson
authors.forename: Tone
authors.initials: T
authors.lastname: Bjørge
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Wegene T
authors.initials: WT
authors.lastname: Borena
authors.forename: Christel
authors.initials: C
authors.lastname: Häggström
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Hans
authors.initials: H
authors.lastname: Concin
authors.forename: Gabriele
authors.initials: G
authors.lastname: Nagel
authors.forename: Randi
authors.initials: R
authors.lastname: Selmer
authors.forename: Dorthe
authors.initials: D
authors.lastname: Johansen
authors.forename: Tanja
authors.initials: T
authors.lastname: Stocks
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
mesh_terms: D000328:Adult; D001317:Austria / Q000453:epidemiology; D001794:Blood Pressure; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D013548:Sweden / Q000453:epidemiology