title: Prostate specific antigen levels after acute myocardial infarction.
abstract: Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.
authors.affiliation: Department of Biochemistry, Zonguldak Karaelmas University, Turkey. serefdenacikgoz@yahoo.com
authors.forename: Şerefden
authors.initials: Ş
authors.lastname: Açıkgöz
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Sait Mesut
authors.initials: SM
authors.lastname: Doğan
authors.forename: Görkem
authors.initials: G
authors.lastname: Mungan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydın
authors.forename: Serdar
authors.initials: S
authors.lastname: Kelek
authors.forename: Vildan
authors.initials: V
authors.lastname: Sümbüloğlu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood / Q000378:metabolism; D004562:Electrocardiography; D006323:Heart Arrest / Q000097:blood / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors; D019210:Troponin I / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D019210:Troponin I; D052279:Creatine Kinase, MB Form; D017430:Prostate-Specific Antigen