title: Detection of novel SNPs and mapping of the fatness QTL  on pig chromosome 7q1.1-1.4 region.
abstract: Many QTLs for fatness traits have been mapped on pig  chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers,  including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and HMGA1 genes, were genotyped in Large White and Meishan pig breeds. Except for two  SNPs in HMGA1 and ABCC10 genes, allele frequencies of the other  eight markers are highly significant different between Chinese indigenous  Meishan breeds and Large White pig breeds. Eight polymorphic sites were then  used for linkage and QTL mapping to refine the fatness QTL in a Large White ×  Meishan F(2) resource  population. Five chromosome-wise significant QTLs were detected, of which the  QTLs for leaf fat weight, backfat thickness at 6-7th rib and rump, and mean  backfat thickness were narrowed to the interval between PPARD and GLP1R genes and the QTL for backfat thickness at thorax-waist between GNMT and PLA2G7 genes on SSC7p1.1-q1.4.
authors.affiliation: Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China.
authors.forename: W H
authors.initials: WH
authors.lastname: Huang
authors.forename: Z X
authors.initials: ZX
authors.lastname: Ma
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Xu
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Xiong
authors.forename: B
authors.initials: B
authors.lastname: Zuo
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001947:Breeding; D002681:China; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000737:chemistry / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D050938:Glycine N-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008460:Meat; D047494:PPAR delta / Q000235:genetics* / Q000378:metabolism; D054467:Phospholipases A2 / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D013552:Swine
chemical_list: D005819:Genetic Markers; D047494:PPAR delta; D050938:Glycine N-Methyltransferase; D054467:Phospholipases A2