title: Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm.
abstract: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimer's disease mouse model.
authors.affiliation: Department of Molecular and Cellular Neurobiology, Nencki Institute, PL-02-093 Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kiryk
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mochol
authors.forename: Robert K
authors.initials: RK
authors.lastname: Filipkowski
authors.forename: Marcin
authors.initials: M
authors.lastname: Wawrzyniak
authors.forename: Victoria
authors.initials: V
authors.lastname: Lioudyno
authors.forename: Ewelina
authors.initials: E
authors.lastname: Knapska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gorkiewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Balcerzyk
authors.forename: Szymon
authors.initials: S
authors.lastname: Leski
authors.forename: Fred Van
authors.initials: FV
authors.lastname: Leuven
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Lipp
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Wojcik
authors.forename: Leszek
authors.initials: L
authors.lastname: Kaczmarek
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D012919:Social Behavior