title: Oxidative stress and renal interstitial fibrosis in patients after renal transplantation: current state of knowledge.
abstract: Long-term outcomes in renal transplantation has represented a major challenge for transplantologists and nephrologists for many years. The use of a new generation of immunosuppressive drugs has contributed to reducing the incidence of acute rejection episodes, but chronic allograft nephropathy is the cause of renal allograft loss in ∼50% of recipients. Organ fibrosis is the main histopathologic finding in those cases. Many researchers have focused on mechanisms leading to fibrosis. It is thought that an explanation of the pathologic mechanism of this phenomenon may improve long-term effects of therapy for kidney transplant recipients.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. karolina.kedzierska@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: Kędzierska
authors.forename: M
authors.initials: M
authors.lastname: Domański
authors.forename: K
authors.initials: K
authors.lastname: Sporniak-Tutak
authors.forename: B
authors.initials: B
authors.lastname: Dołęgowska
authors.forename: K
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000818:Animals; D002908:Chronic Disease; D005355:Fibrosis; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007674:Kidney Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents