title: Large chromatin domains in pluripotent and differentiated cells.
abstract: Pluripotent stem cells are able to proliferate unlimitedly and to generate all somatic cell types, thus holding a great promise in medical applications. Epigenetic modifications are believed to play crucial roles in regulating pluripotency and differentiation. Recent genome-wide studies on mammalian systems have revealed several types of large chromatin domains which are associated with higher-order organization of the genome. The elucidation of genomic distribution and dynamics of these domains have shed light on the mechanisms underling pluripotency and lineage commitment.
authors.affiliation: Department of Biochemistry and Molecular Biology & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, China.
authors.forename: Shibin
authors.initials: S
authors.lastname: Hu
authors.forename: Lu
authors.initials: L
authors.lastname: Cheng
authors.forename: Bo
authors.initials: B
authors.lastname: Wen
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D002843:Chromatin / Q000378:metabolism*; D053595:Embryonic Stem Cells / Q000502:physiology*; D044127:Epigenesis, Genetic; D016678:Genome; D006570:Heterochromatin / Q000502:physiology; D006657:Histones / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology; D008239:Lysine / Q000378:metabolism; D051379:Mice; D039904:Pluripotent Stem Cells / Q000502:physiology*
chemical_list: D002843:Chromatin; D006570:Heterochromatin; D006657:Histones; D008239:Lysine