title: Long-term tumor control and cranial nerve outcomes following γ knife surgery for larger-volume vestibular schwannomas.
abstract: OBJECTIVE
  γ knife surgery (GKS) for vestibular schwannoma (VS) is an accepted treatment for small- to medium-sized tumors, generally smaller than 2.5 cm in the maximum posterior fossa dimension. The purpose of this study was to evaluate the efficacy and toxicity of GKS for larger tumors.
  
  
  METHODS
  Prospectively collected data were analyzed for 22 patients who had undergone GKS for VSs larger than 2.5 cm in the posterior fossa diameter between 1997 and 2006. No patient had symptomatic brainstem compression at the time of GKS. The median treated tumor volume was 9.4 cm(3) (range 5.3-19.1 cm(3)). The median maximum posterior fossa diameter was 2.8 cm (range 2.5-3.8 cm). The median tumor margin dose was 12 Gy (range 12-14 Gy). Serial imaging, audiometry (10 patients with serviceable hearing pre-GKS), and clinical follow-up were available for a median of 66 months (range 26-121 months). Tumor control failure was defined as either a progressive increase in tumor diameter of at least 2 mm in any dimension or a later resection.
  
  
  RESULTS
  Four patients met the criteria for GKS failure, including 1 patient who demonstrated sarcomatous degeneration more than 7 years after GKS and died 3 months after microsurgical debulking. An enlarging cystic component was the surgical indication in 1 of the 2 patients who required resection, although 27% of tumors (6 lesions) were cystic before GKS. The 3-year actuarial rate of tumor control, freedom from new facial neuropathy, and preservation of functional hearing were 86%, 92%, and 47%, respectively. At 5 years post-GKS, these rates decreased to 82%, 85%, and 28%, respectively. At the most recent follow-up, 91% of tumors were smaller than at the time of GKS and the median maximum posterior fossa diameter reduction was 26%. On multivariate analysis, none of the following factors was associated with GKS failure, new facial weakness, new trigeminal neuropathy, or loss of serviceable hearing: patient age, tumor volume, tumor margin dose, and preoperative cranial nerve dysfunction.
  
  
  CONCLUSIONS
  Single-session radiosurgery is a successful treatment for the majority of patients with larger VSs. Although tumor control rates are lower than those for smaller VSs managed with GKS, the cranial nerve morbidity of GKS is significantly lower than that typically achieved via resection of larger VSs.
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Milligan
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Pollock
authors.forename: Robert L
authors.initials: RL
authors.lastname: Foote
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Link
mesh_terms: D000368:Aged; D001299:Audiometry; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000150:complications / Q000208:ethnology / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D011829:Radiation Dosage; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome; D000159:Vestibulocochlear Nerve / Q000473:pathology / Q000601:surgery*