title: Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.
authors.affiliation: Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, Building G878, 65926 Frankfurt am Main, Germany. marc.nazare@sanofi-aventis.com
authors.forename: Marc
authors.initials: M
authors.lastname: Nazaré
authors.forename: Hans
authors.initials: H
authors.lastname: Matter
authors.forename: David W
authors.initials: DW
authors.lastname: Will
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.forename: Matthias
authors.initials: M
authors.lastname: Urmann
authors.forename: Jörg
authors.initials: J
authors.lastname: Czech
authors.forename: Herman
authors.initials: H
authors.lastname: Schreuder
authors.forename: Armin
authors.initials: A
authors.lastname: Bauer
authors.forename: Kurt
authors.initials: K
authors.lastname: Ritter
authors.forename: Volkmar
authors.initials: V
authors.lastname: Wehner
mesh_terms: D000577:Amides / Q000737:chemistry; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D008024:Ligands; D017434:Protein Structure, Tertiary; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000577:Amides; D065427:Factor Xa Inhibitors; D008024:Ligands; D015842:Serine Proteinase Inhibitors; D015951:Factor Xa