title: Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases.
abstract: BACKGROUND
  Extraosseous plasmacytoma, so called extramedullary plasmacytoma (EMP) is relatively rare in China. The aim was investigate the clinicopathologic features of EMP and the role of Immunophenotype and genotype detection in diagnosis of EMP.
  
  
  METHODS
  Thirty-two cases of EMP were investigated retrospectively by histopathology, immunophenotype, genotype and survival analysis.
  
  
  RESULTS
  Clinically, the mean age of the patients was 53.4. Most of the patients received no treatment after the diagnosis was established, and the prognosis was relatively poor. Histologically, in 40% of the cases, the neoplastic cells were grade II or III. The neoplastic cells expressed one or more PC associated antigens. The immunophenotype of EMP and inflammation of sinonasal regions with numerous PC infiltrations were compared and showed some difference in expression of CD45, CD27, CD44v6 and Bcl-2 as well. Ig light chain restriction was detected in 87.5% of the cases.
  
  
  CONCLUSIONS
  we described 32 Chinese cases of EMP, compare with that reported in the literature, some differences are presented, including higher percentage of grade II and III cases, clinically inconsistent treatment and management as well as poor outcome of the disease.
authors.affiliation: Department of Pathology, West China Hospital of Sichuan University, Chengdu, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zuo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tang
authors.forename: Cheng-Feng
authors.initials: CF
authors.lastname: Bi
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Zhang
authors.forename: Sha
authors.initials: S
authors.lastname: Zhao
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
authors.forename: Qun-Pei
authors.initials: QP
authors.lastname: Yang
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Zou
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D060787:Neoplasm Grading; D010954:Plasmacytoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*