title: [PSA bounce after brachytherapy with permanent seed implantation for prostate cancer].
abstract: OBJECTIVE
  To evaluate prostate specific antigen (PSA) bounce that may occur as a time PSA rise phenomenon during follow up period after brachytherapy (BT) with permanent seed implantation for prostate cancer. (Materials and methods) Seven hundred and forty-six patients had undergone BT from November 2003 to April 2007 in a single institute, and of 130 patients who did not receive hormone therapy and had minimal 3-year follow up are analyzed. PSA bounce was defined as a rise of at least 0.4 ng/ml with spontaneous return to pre-bounce level or lower.
  
  
  RESULTS
  Among the 130 patients, 40 patients (30.8%) developed PSA bounce, and median time to PSA bounce was 18 months after the BT. With univariate analysis, younger patients (P = 0.027) and larger prostate (P = 0.030) had statistically significant correlation with PSA bounce. With multivariate analysis, younger patients were identified as only independent factor for predicting PSA bounce. Eight patients out of 130 patients (6.2%) triggered the Phoenix definition (nadir + 2 ng/ml) of PSA failure, however, clinical failure was seen only in 3 patients, and other 5 patients were considered as PSA bounce.
  
  
  CONCLUSIONS
  PSA bounce is likely to occur in younger patients within 3 years after BT. It is clinically important to distinguish PSA bounce from PSA failure during following period after BT.
authors.affiliation: The Department of Urology, National Hospital Organization Tokyo Medical Center.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Yagi
authors.forename: Ryo
authors.initials: R
authors.lastname: Namitome
authors.forename: Yuho
authors.initials: Y
authors.lastname: Kono
authors.forename: Toru
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Toya
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yorozu
authors.forename: Shiro
authors.initials: S
authors.lastname: Saito
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000532:radiotherapy*
chemical_list: D017430:Prostate-Specific Antigen