title: Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium.
abstract: To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.
authors.affiliation: National Office of Cancer Prevention and Control, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China; International Agency for Research on Cancer, Lyon, France.
authors.forename: Qian
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authors.lastname: Li
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Chuang
authors.forename: Jose
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authors.lastname: Eluf-Neto
authors.forename: Ana
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authors.lastname: Menezes
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authors.forename: Sergio
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authors.lastname: Koifman
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authors.lastname: Wünsch-Filho
authors.forename: Leticia
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authors.lastname: Fernandez
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Daudt
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Curado
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Winn
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Rolando
authors.initials: R
authors.lastname: Herrero
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsague
authors.forename: Hal
authors.initials: H
authors.lastname: Morgenstern
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Philip
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authors.lastname: Lazarus
authors.forename: Joshua
authors.initials: J
authors.lastname: Muscat
authors.forename: Michael
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authors.lastname: McClean
authors.forename: Karl T
authors.initials: KT
authors.lastname: Kelsey
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Schwartz
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Olshan
authors.forename: Guopei
authors.initials: G
authors.lastname: Yu
authors.forename: Stimson
authors.initials: S
authors.lastname: Schantz
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019587:Dietary Supplements; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals; D018570:Risk Assessment; D012307:Risk Factors; D014815:Vitamins
chemical_list: D008903:Minerals; D014815:Vitamins