title: Human CD90 identifies Th17/Tc17 T cell subsets that are depleted in HIV-infected patients.
abstract: By revisiting CD90, a GPI-anchored glycoprotein, we show that CD90 is expressed by a subset of CD4(+) and CD8(+) human T cells. CD4(+)CD90(+) cells share similarities with Th17 cells because they express the Th17-specific transcription factor RORC2 and produce IL-17A. CD4(+)CD90(+) cells are activated memory T cells that express the gut mucosal markers CCR6, CD161, and the α(4) and β(7) integrins. Compared with CD90-depleted CCR6(+) memory Th17 cells, CD4(+)CD90(+) cells express higher levels of IL-22 and proinflammatory cytokines (IL-6, TNF-α and GM-CSF), but they produce lower levels of IL-21 and no IL-9. Analyses of CD8(+)CD90(+) cells reveal that they express RORC2 and are able to produce higher levels of IL-17A, IL-22, and CCL20 compared with CD90-depleted CD8(+) cells. These data show that CD90 identifies Th17 and Tc17 cells with a peculiar cytokine profile. Studies of circulating CD90(+) cells in HIV patients show that CD90(+) cells are decreased with an imbalance of the CD4(+)CD90(+)/regulatory T cell ratio in nontreated patients compared with treated patients and healthy donors. Overall, human CD90 identifies a subset of Th17 and Tc17 cells within CD4(+) and CD8(+) T cells, respectively, which are depleted during HIV infection.
authors.affiliation: Université Pierre et Marie Curie-Université Paris 06, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7211/INSERM 959, 75005 Paris, France.
authors.forename: Maude
authors.initials: M
authors.lastname: Guillot-Delost
authors.forename: Sabine
authors.initials: S
authors.lastname: Le Gouvello
authors.forename: Mariana
authors.initials: M
authors.lastname: Mesel-Lemoine
authors.forename: Mustapha
authors.initials: M
authors.lastname: Cheraï
authors.forename: Claude
authors.initials: C
authors.lastname: Baillou
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Yves
authors.initials: Y
authors.lastname: Levy
authors.forename: Laurence
authors.initials: L
authors.lastname: Weiss
authors.forename: Samy
authors.initials: S
authors.lastname: Louafi
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chaput
authors.forename: François
authors.initials: F
authors.lastname: Berrehar
authors.forename: Stéphane
authors.initials: S
authors.lastname: Kerbrat
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.forename: François M
authors.initials: FM
authors.lastname: Lemoine
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000821:virology; D054418:Chemokine CCL20; D016207:Cytokines / Q000032:analysis; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology / Q000821:virology*; D058504:Th17 Cells / Q000473:pathology* / Q000821:virology; D018800:Thy-1 Antigens; D000097043:Interleukin-22
chemical_list: D054418:Chemokine CCL20; D016207:Cytokines; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018800:Thy-1 Antigens; D000097043:Interleukin-22; C108355:CCL20 protein, human; C539900:RORC protein, human