title: A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe.
abstract: The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.
authors.affiliation: LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Albertoni
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Hannam
authors.forename: Damian
authors.initials: D
authors.lastname: Ackermann
authors.forename: Anton
authors.initials: A
authors.lastname: Schmitz
authors.forename: Michael
authors.initials: M
authors.lastname: Famulok
mesh_terms: D001389:Azirines / Q000138:chemical synthesis / Q000737:chemistry*; D020690:GTPase-Activating Proteins / Q000032:analysis; D057809:HEK293 Cells; D006801:Humans; D019920:Photoaffinity Labels / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C524668:(3-trifluoromethyl) phenyldiazirine; D001389:Azirines; D020690:GTPase-Activating Proteins; D019920:Photoaffinity Labels; C516025:SecinH3; D014230:Triazoles; C102474:cytohesin-2