title: Effects of artemisinin dimers on rat breast cancer cells in vitro and in vivo.
abstract: Artemisinin has been shown to be an effective antimalarial and anticancer compound. Dimers of artemisinin have been synthesized and shown to be potent antimalarials compared with monomers. In the present study, we investigated the effect of two artemisinin dimers (dimer-alcohol and dimer-hydrazone) on rat mammary adenocarcinoma cells (MTLn3) in vitro and in vivo compared with that of the artemisinin monomer dihydroartemisinin (DHA). We found that the dimers are considerably more potent than DHA in killing MTLn3 cells in vitro and suppressing the growth of MTLn3 breast tumors in vivo.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, USA.
authors.forename: Narendra P
authors.initials: NP
authors.lastname: Singh
authors.forename: Henry C
authors.initials: HC
authors.lastname: Lai
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Park
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Gerhardt
authors.forename: Byung Ju
authors.initials: BJ
authors.lastname: Kim
authors.forename: Shusheng
authors.initials: S
authors.lastname: Wang
authors.forename: Tomikazu
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry; D037621:Artemisinins / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D019281:Dimerization; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000378:metabolism*; D008956:Models, Chemical; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
chemical_list: D000438:Alcohols; D000890:Anti-Infective Agents; D000975:Antioxidants; D037621:Artemisinins; C039060:artenimol; C031327:artemisinin