title: Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma.
abstract: The hepatocellular carcinoma (HCC) is one of the most common malignant tumors. It carries a poor survival rate and has an increasing incidence worldwide. In most cases, HCC is diagnosed at a late stage. Therefore, the prognosis of patients with HCC is generally poor and has a less than 5% 5-year survival rate. The aim of this study was compare the accuracy of α-fetoprotein (AFP), des-γ- carboxy prothrombin (DCP), squamous cell carcinoma antigen-immunoglobulin M complexes (SCCA-IgM Cs) in the early diagnosis and in the prognosis of HCC. A literature search identified the markers for hepatocellular carcinoma. A search of the literature was made using cancer literature and the PubMed database for the following keywords: "markers and HCC", "α-fetoprotein (AFP) and HCC", "Des-γ-carboxy prothrombin"(DCP) and HCC, "squamous cell carcinoma antigen-immunoglobulin M complexes" (SCCA-IgM Cs). Despite the large number of studies devoted to the immunohistochemistry of HCC, at the present time, the absolute positive and negative markers for HCC are still lacking, and even those characterized by very high sensitivity and specificity do not have an universal diagnostic usefulness. In conclusion none of the three biomarkers (AFP, DCP, SCCA-IgM Cs) is optimal. According to recent reviews, these biomarkers should be measured simultaneously and in combination with imaging techniques to increase the sensitivity, specificity, diagnostic accuracy and to make a reliable prognosis. Currently the recommended screening strategy for patients with cirrhosis includes the determination of serum AFP levels and an abdominal ultrasound every six months to detect HCC at an earlier stage.
authors.affiliation: Department of Internal Medicine and Systemic Diseases, Catania University, Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bertino
authors.forename: S
authors.initials: S
authors.lastname: Neri
authors.forename: C M
authors.initials: CM
authors.lastname: Bruno
authors.forename: A M
authors.initials: AM
authors.lastname: Ardiri
authors.forename: G S
authors.initials: GS
authors.lastname: Calvagno
authors.forename: M
authors.initials: M
authors.lastname: Malaguarnera
authors.forename: A
authors.initials: A
authors.lastname: Toro
authors.forename: M
authors.initials: M
authors.lastname: Malaguarnera
authors.forename: S
authors.initials: S
authors.lastname: Clementi
authors.forename: N
authors.initials: N
authors.lastname: Bertino
authors.forename: I
authors.initials: I
authors.lastname: Di Carlo
mesh_terms: D000936:Antigen-Antibody Complex / Q000097:blood; D000951:Antigens, Neoplasm / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin; D015843:Serpins / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D015415:Biomarkers; D014408:Biomarkers, Tumor; D007075:Immunoglobulin M; D011498:Protein Precursors; D015843:Serpins; D000509:alpha-Fetoproteins; C051072:squamous cell carcinoma-related antigen; C008208:acarboxyprothrombin; D011516:Prothrombin