title: [Incidence of coronary artery disease and outcome of patients with left ventricular noncompaction].
abstract: OBJECTIVE
  To analyze the incidence of coronary artery disease (CAD) and outcome of patients with left ventricular noncompaction (LVNC).
  
  
  METHODS
  Fifty-one patients with LVNC evaluated by echocardiography and/or cardiac magnetic resonance (CMR) from January 2006 to August 2010 were retrospectively reviewed. Coronary angiography or MDCT was performed for detecting coronary artery disease. Predictors of the cardiac events were analyzed by Cox regression analysis.
  
  
  RESULTS
  There were 31 LVNC patients without CAD and 20 LVNC patients with CAD including single vessel coronary disease in 9 cases, double vessel coronary disease in 3 cases, three vessel coronary disease in 5 cases and left main coronary disease in 3 cases. Coronary artery bypass graft and percutaneous coronary intervention (PCI) were performed in 4 patients. Compared to LVNC patients without CAD, mean age (P = 0.008), incidence of hypertension (65.0% vs. 19.4%, P = 0.001), diabetes mellitus (40.0% vs. 12.9%, P = 0.026) and hyperlipidemia (55.0% vs. 25.8%, P = 0.035) were significantly higher while NT-proBNP level was significantly lower (P = 0.049) in LVNC patients with CAD. Incidence of major cardiac events was similar in LVNC patients with or without CAD. LogNT-proBNP is the independent prognostic factor for adverse cardiac events in patients with LVNC (HR 3.993, 95%CI 1.140 - 13.988, P = 0.030).
  
  
  CONCLUSIONS
  Coronary artery disease is common in patients with LVNC and associated with traditional risk factors for CAD. Poor prognosis is associated with increased NT-proBNP but not with CAD in this patient cohort.
authors.affiliation: Department of Cardiology, Fuwai Hospital, Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Xiao-jin
authors.initials: XJ
authors.lastname: Gao
authors.forename: Lian-ming
authors.initials: LM
authors.lastname: Kang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Shi-hua
authors.initials: SH
authors.lastname: Zhao
authors.forename: Min-jie
authors.initials: MJ
authors.lastname: Lu
authors.forename: Huai-bing
authors.initials: HB
authors.lastname: Cheng
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Luo
authors.forename: Wen
authors.initials: W
authors.lastname: Jiang
authors.forename: Rong
authors.initials: R
authors.lastname: Lü
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D015994:Incidence; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult