title: Organocatalytic Michael-Knoevenagel-hetero-Diels-Alder reactions: an efficient asymmetric one-pot strategy to isochromene pyrimidinedione derivatives.
abstract: Synthesis of isochromene pyrimidinedione derivatives having five stereocenters has been achieved by a one-pot Michael-Knoevenagel condensation-inverse-electron-demand hetero-Diels-Alder reaction of α, β-unsaturated aldehydes, olefinic nitroalkanes, and 1,3-dimethylbarbituric acid via a one-pot strategy with excellent diastereo- and enantioselectivities (up to 99% ee). The structures and absolute configurations of the products were confirmed by X-ray analysis.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, ROC.
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Nitin S
authors.initials: NS
authors.lastname: Dange
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Ding
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao