title: The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
authors.affiliation: Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, United States. Agman@chem.northwestern.edu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Silverman
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001363:Awards and Prizes; D019970:Cocaine-Related Disorders / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008958:Models, Molecular; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013036:Spasms, Infantile / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000188:drug therapy*; D014481:United States; D020888:Vigabatrin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C519726:(1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid; D000927:Anticonvulsants; D011392:Proline; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin