title: Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumab.
abstract: Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms and palivizumab resistance in clinical RSV isolates collected from immunoprophylaxis-naive subjects. Polymorphisms were identified at low frequency, and only polymorphic mutations in antigenic site A (<1% of all polymorphisms) conferred palivizumab resistance.
authors.affiliation: Department of Infectious Disease-Vaccines, MedImmune, Gaithersburg, Maryland, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Nita K
authors.initials: NK
authors.lastname: Patel
authors.forename: Josephine M
authors.initials: JM
authors.lastname: McAuliffe
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Leslie
authors.initials: L
authors.lastname: Wachter
authors.forename: Michael P
authors.initials: MP
authors.lastname: McCarthy
authors.forename: Joann A
authors.initials: JA
authors.lastname: Suzich
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology*; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D000998:Antiviral Agents / Q000494:pharmacology*; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D000939:Epitopes / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020125:Mutation, Missense; D000069455:Palivizumab; D011110:Polymorphism, Genetic; D012136:Respiratory Syncytial Viruses / Q000235:genetics*; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000956:Antigens, Viral; D000998:Antiviral Agents; D000939:Epitopes; C526850:F protein, human respiratory syncytial virus; D014760:Viral Fusion Proteins; D000069455:Palivizumab