title: Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α ligand binding domain (ERα-LBD).
abstract: A series of 17α-(heteroaryl)vinyl estradiols was prepared to evaluate the influence of heteroatom on the affinity and efficacy of estrogenic ligands for the estrogen receptor-alpha ligand binding domain (ERα-LBD). The products demonstrated reduced binding affinity compared to the parent 17α-E-phenyl vinyl estradiol, but the binding was relatively independent of the heteroatom. The greatest influence of the heteroatom was evident in the efficacy of the compounds as the thienyl derivatives 2f,g were more potent than either the pyridyl 2b-d or pyrimidinyl 2e analogs. The results suggest that a subtle interplay of interactions between the ligands and the receptor influences the biological response.
authors.affiliation: Department of Chemistry, Augsburg College, 2211 Riverside Avenue, Minneapolis, MN 55454, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Olmsted
authors.forename: Pakamas
authors.initials: P
authors.lastname: Tongcharoensirikul
authors.forename: Emmett
authors.initials: E
authors.lastname: McCaskill
authors.forename: Karla
authors.initials: K
authors.lastname: Gandiaga
authors.forename: David
authors.initials: D
authors.lastname: Labaree
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hochberg
authors.forename: Robert N
authors.initials: RN
authors.lastname: Hanson
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D047628:Estrogen Receptor alpha / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D047628:Estrogen Receptor alpha; D008024:Ligands; D004958:Estradiol