title: Female rats are more susceptible to the deleterious effects of paradoxical sleep deprivation on cognitive performance.
abstract: Paradoxical sleep deprivation (PSD) may alter subsequent learning and memory capacity. There are differences in both the intensity and direction of responses of the male and female species to the same environmental stimuli and experimental conditions. In the present study, we examined the extent of the effects of PSD for 72h on spatial learning and memory, anxiety-like behavior, corticosterone levels, and the body weight in male as well as in intact and ovariectomized (OVX) female Wistar rats. Multiple platform method was used for PSD induction. Spatial learning and memory and anxiety-like behavior were determined using Morris water maze (MWM) task and open field test, respectively. The data showed that PSD could not significantly affect subsequent spatial learning and short-term memory in male rats, while it significantly impaired the performance of the intact and OVX female rats. The PSD-intact and -OVX female rats showed more memory impairment than the PSD-male animals. Those impairments do not appear to be due to elevated stress level, since the plasma corticosterone did not significantly change following PSD induction. The open field data showed that PSD significantly reduced anxiety-like behavior in all experimental groups. In addition, PSD had a reducing effect on the mean body weight of female groups. Such results suggest that the female rats are more vulnerable to the deleterious effects of sleep loss on cognitive performance.
authors.affiliation: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran. Vahajali@yahoo.com
authors.forename: Vahid
authors.initials: V
authors.lastname: Hajali
authors.forename: Vahid
authors.initials: V
authors.lastname: Sheibani
authors.forename: Saeed
authors.initials: S
authors.lastname: Esmaeili-Mahani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shabani
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000523:psychology; D001835:Body Weight; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology*; D003345:Corticosterone / Q000097:blood; D005106:Exploratory Behavior; D005260:Female; D008297:Male; D018782:Maze Learning; D008568:Memory / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D012892:Sleep Deprivation / Q000150:complications*; D012895:Sleep, REM / Q000502:physiology*; D013028:Space Perception; D013550:Swimming / Q000523:psychology
chemical_list: D003345:Corticosterone