title: Reoxygenation of glioblastoma multiforme treated with fractionated radiotherapy concomitant with temozolomide: changes defined by 18F-fluoromisonidazole positron emission tomography: two case reports.
abstract: Two glioblastoma multiforme patients underwent (18)F-FMISO (fluoromisonidazole) positron emission tomography study to access the tumor oxygenation status before and immediately after fractionated radiotherapy concomitant with temozolomide chemotherapy. In both cases, a prominent (18)F-FMISO tumor accumulation observed in the first study was notably decreased in the second study, which was supposed to be a reoxygenation of the tumor. As far as we investigated, this is the first report of the changes of oxygenation status in glioblastoma multiforme treated through radiation therapy with temozolomide.
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. t-narita@med.hokudai.ac.jp
authors.forename: Takuhito
authors.initials: T
authors.lastname: Narita
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirata
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Onodera
authors.forename: Tohru
authors.initials: T
authors.lastname: Shiga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Junichi
authors.initials: J
authors.lastname: Murata
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Terasaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Houkin
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D015687:Cell Hypoxia / Q000187:drug effects / Q000528:radiation effects; D059186:Chemoradiotherapy, Adjuvant; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008920:Misonidazole / Q000031:analogs & derivatives*; D010100:Oxygen / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011838:Radiation-Sensitizing Agents; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D011838:Radiation-Sensitizing Agents; C031843:fluoromisonidazole; D003606:Dacarbazine; D008920:Misonidazole; D010100:Oxygen; D000077204:Temozolomide