title: Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent Tunisian patients with acute neuromeningeal disorder.
abstract: Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourguiba University Hospital (Monastir, Tunisia) between September 2007 and June 2009. At least one viral genome was detected in 58 (46%) out of 126 CSF samples collected. Enterovirus was detected in 31 of the positive samples (53.4%), CMV in 20 (34.5%), HSV-1 in 3 (5.2%), HSV-2 in 6 (10.3%), VZV in 4 (6.9%), HHV-6 in 2 (3.4%). More than one viral genome was detected in seven CSF samples, including CMV DNA in six of the samples. The high frequency of enteroviral infections in aseptic meningitis was confirmed. The detection of CMV DNA only suggests a direct role of this virus in the etiology of acute neuromeningeal disorder.
authors.affiliation: Laboratory of Contagious Diseases and Biologically Active Substances, LR99-ES27, Faculty of Pharmacy, Monastir University, Monastir, Tunisia. amen_nahdi@yahoo.fr
authors.forename: Imen
authors.initials: I
authors.lastname: Nahdi
authors.forename: Hanen
authors.initials: H
authors.lastname: Boukoum
authors.forename: Abid
authors.initials: A
authors.lastname: Nabil Ben Salem
authors.forename: Fouad
authors.initials: F
authors.lastname: Ben Romdane
authors.forename: Saber
authors.initials: S
authors.lastname: Hammami
authors.forename: Saber
authors.initials: S
authors.lastname: Chebel
authors.forename: Frih-Ayed
authors.initials: FA
authors.lastname: Mahbouba
authors.forename: Mohamed Neji
authors.initials: MN
authors.lastname: Guediche
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chakroun
authors.forename: Mahjoub
authors.initials: M
authors.lastname: Aouni
authors.forename: Berthe-Marie
authors.initials: BM
authors.lastname: Imbert-Marcille
authors.forename: Celine
authors.initials: C
authors.lastname: Bressollette-Bodin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000134:cerebrospinal fluid*; D005260:Female; D006564:Herpesviridae / Q000276:immunology / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid* / Q000453:epidemiology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008578:Meninges / Q000473:pathology / Q000821:virology; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral