title: Synthesis and hydrolysis studies of novel glyco-functionalized platinum complexes.
abstract: Cisplatin and some of its derivatives are among the most active cytostatics for cancer treatment. Unfortunately, application of platinum complexes always indicates side effects, and frequently primary or developed resistance of tumour cells appear. Therefore, development of novel analogues especially with natural ligands is expedited. Glyco-functionalized ligands were obtained via ether synthesis with ω-halo ethers, Finkelstein reaction, with further treatment with malonate and final deprotection followed by preparation of the disodium salts. Subsequent complexation led to novel platinum derivatives, the stabilities of which in aqueous solution media were studied.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Möker
authors.forename: Joachim
authors.initials: J
authors.lastname: Thiem
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004355:Drug Stability; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D008314:Malonates / Q000737:chemistry; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D006001:Glycoconjugates; D008314:Malonates; D009944:Organoplatinum Compounds; D014867:Water