title: Incidence of late occurring bradyarrhythmias after TAVI with the self-expanding CoreValve(®) aortic bioprosthesis.
abstract: OBJECTIVE
  Analysis of timing, type, electrocardiographic and patient characteristics of postinterventional bradyarrhythmias after CoreValve implantation.
  
  
  BACKGROUND
  Transcatheter aortic valve implantation (TAVI) has become an accepted alternative to surgical therapy in patients with high risk. Among the major drawbacks of this procedure is the need for postprocedural permanent pacemaker implantation (PPM). Although predictors for the postinterventional need for PPM are increasingly recognized, thresholds and rates may vary between centers.
  
  
  METHODS
  We conducted a retrospective single-center analysis in 130 consecutive patients with successful transfemoral CoreValve implantation without preexisting pacemaker implants.
  
  
  RESULTS
  Postprocedural bradyarrhythmias occurred in 36.2% post-TAVI. Compared to those without postinterventional bradyarrhythmias, these patients had longer preprocedural PR intervals (P = 0.012), broader QRS-complexes (P = 0.001) and prolonged QTc intervals (P = 0.001). Patients with postinterventional bradyarrhythmias had significantly more often preprocedural RBBB (35.2 vs. 14.1%; P = 0.0059). In contrast, no difference was observed with respect to annulus/prosthesis ratio or the use of the large 29-mm prosthesis. The vast majority of patients developed bradyarrhythmias directly after CoreValve implantation or within the first 48 h thereafter. However, 7.6% developed significant bradyarrhythmia more than 48 h after TAVI, and 3.8% of the whole cohort developed significant bradyarrhythmias even >96 h after TAVI. One patient died at day 5 post-TAVI due to asystole.
  
  
  CONCLUSIONS
  Late occurrence of bradyarrhythmias should be recognized as a significant contributor to postprocedural outcome after TAVI. Although this is a well known phenomenon after surgical valve replacement, it is less recognized after TAVI.
authors.affiliation: Department of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. e.chorianopoulos@med.uni-heidelberg.de
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chorianopoulos
authors.forename: Ulrike
authors.initials: U
authors.lastname: Krumsdorf
authors.forename: Sven T
authors.initials: ST
authors.lastname: Pleger
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.forename: Raffi
authors.initials: R
authors.lastname: Bekeredjian
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis / Q000009:adverse effects*; D001919:Bradycardia / Q000453:epidemiology / Q000209:etiology*; D006328:Cardiac Catheterization; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D011474:Prosthesis Design; D012044:Regression Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome