title: Biosynthesis of 3,5-AHBA-derived natural products.
abstract: Covering: 1957 to 2011. 3-Amino-5-hydroxy benzoic acid (3,5-AHBA) is a precursor for a large group of natural products, including the family of naphthalenic and benzenic ansamycins, the unique saliniketals, and the family of mitomycins. This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited.
authors.affiliation: State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Kang
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
authors.forename: Linquan
authors.initials: L
authors.lastname: Bai
mesh_terms: D000192:Actinomycetales / Q000201:enzymology / Q000235:genetics; D062365:Aminobenzoates / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D053898:Biosynthetic Pathways / Q000502:physiology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D062385:Hydroxybenzoates; D008453:Maytansine / Q000096:biosynthesis*; D016685:Mitomycin / Q000096:biosynthesis*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry; D012294:Rifamycins / Q000096:biosynthesis*
chemical_list: D062365:Aminobenzoates; D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D062385:Hydroxybenzoates; D009285:Naphthoquinones; D012294:Rifamycins; C517709:saliniketal A; C517708:saliniketal B; D008453:Maytansine; D016685:Mitomycin; C010252:naphthomycin; C031509:3-amino-5-hydroxybenzoic acid