title: Preparation of electrospun PLGA-silk fibroin nanofibers-based nerve conduits and evaluation in vivo.
abstract: With advances in technical methodology, the grafting of biocompatible conduits may become a viable alternative for the reconstruction of nerve gaps. In this study, electrospinning was used to fabricate nerve conduits (NCs) from poly(L-lactide-coglycolide)-silk fibroin. Conduits or autograft nerves were employed to bridge 10 mm defects in the sciatic nerves of Sprague-Dawley rats. Six weeks after the operation, morphological and functional assessment showed that nerve conduits from PLGA-silk fibroin grafts promoted the regeneration of peripheral nerves. The effects were similar to those obtained using nerve autografts. This method offers a promising alternative to the use of nerve autografts.
authors.affiliation: Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Hu
authors.forename: Chong-Qi
authors.initials: CQ
authors.lastname: Tu
authors.forename: Fu-Xing
authors.initials: FX
authors.lastname: Pei
authors.forename: Guang-Lin
authors.initials: GL
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Hong-Song
authors.initials: HS
authors.lastname: Fan
mesh_terms: D000818:Animals; D005349:Fibroins / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009416:Nerve Regeneration / Q000187:drug effects; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005349:Fibroins