title: Acute pulmonary embolism in patients with obstructive sleep apnoea: does it affect the severity of sleep-disordered breathing?
abstract: BACKGROUND
  Acute pulmonary embolism (PE) may result in an increase in central venous pressure, which may contribute to pharyngeal narrowing by fluid accumulation in nuchal and peripharyngeal soft tissues and therefore affect obstructive sleep apnoea (OSA).
  
  
  OBJECTIVE
  This study aimed to clarify the impact of acute PE on the severity of sleep-disordered breathing in OSA patients.
  
  
  METHODS
  Polysomnography (PSG) was performed in 15 OSA patients shortly after acute PE and again after 3 months of sufficient anticoagulation therapy. OSA remained untreated meanwhile.
  
  
  RESULTS
  Acute PE did not significantly affect the apnoea-hypopnoea index (AHI).
  
  
  CONCLUSIONS
  The diagnosis of OSA is representative in acute PE, as the transient increase of central venous pressure seems not to affect the AHI once the patients are clinical stable for PSG.
authors.affiliation: Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum Augsburg, Ludwig-Maximilians-University Munich, Stenglinstrasse 2, 86156, Augsburg, Germany. thomas.berghaus@klinikum-augsburg.de
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Berghaus
authors.forename: Christian
authors.initials: C
authors.lastname: Faul
authors.forename: Fabian
authors.initials: F
authors.lastname: Unterer
authors.forename: Christian
authors.initials: C
authors.lastname: Thilo
authors.forename: Wolfgang
authors.initials: W
authors.lastname: von Scheidt
authors.forename: Martin
authors.initials: M
authors.lastname: Schwaiblmair
mesh_terms: D000208:Acute Disease; D000368:Aged; D000403:Airway Resistance / Q000502:physiology; D000925:Anticoagulants / Q000627:therapeutic use; D002496:Central Venous Pressure / Q000502:physiology; D017984:Enoxaparin / Q000627:therapeutic use; D005260:Female; D018495:Fluid Shifts / Q000502:physiology; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011655:Pulmonary Embolism / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin