title: [A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review].
abstract: OBJECTIVE
  To investigate the clinical features and treatment protocol and prognosis for the hypophosphataemic osteomalacia related to adefovir dipivoxil.
  
  
  METHODS
  Analysis was made upon a case of patient with chronic hepatitis B developed hypophosphataemic osteomalacia after administration of adefovir dipivoxil. Literature review was carried out to survey the global prevalence of hypophosphataemic osteomalacia after administration of adefovir dipivoxil among patients with chronic hepatitis B.
  
  
  RESULTS
  The clinical symptoms started paralleling to the time taking adefovir dipivoxil, and alleviated after the patient withdrawn adefovir dipivoxil 10 weeks and was given phosphorus. Meanwhile, serum inorganic phosphorus recovered to normal (0.98 mmol/L), which lowest level was 0.77 mmol/L. Systematic review of the literature showed that hyperphosphaturia related to adefovir dipivoxil was dose-dependent, time-dependent and reversible. All reported cases of hypophosphataemic osteomalacia secondary to adefovir dipivoxil (10 mg/d) were from Asian population.
  
  
  CONCLUSIONS
  Adefovir dipivoxil induced hypophosphataemic osteomalacia is rarely seen in clinical practice. Those patients with chronic hepatitis B who take adefovir dipivoxil, no matter dosages, should take periodical examinations including blood calcium and serum inorganic phosphorus to monitor whether hypophosphataemic osteomalacia occurs. Other anti-virus drugs could be used when it happens.
authors.affiliation: Department of Endocrinology, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiao-fang
authors.initials: XF
authors.lastname: Sun
authors.forename: Hua-bing
authors.initials: HB
authors.lastname: Zhang
authors.forename: Xin-ping
authors.initials: XP
authors.lastname: Li
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Xia
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xing
authors.forename: Xun-wu
authors.initials: XW
authors.lastname: Meng
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects*; D010018:Osteomalacia / Q000139:chemically induced*
chemical_list: D063065:Organophosphonates; D000225:Adenine; C106812:adefovir dipivoxil