title: Inhibition of lactophage activity by quinolinilporphyrin and its zinc compex.
abstract: The influence of free base of quinolinilporphyrin and its Zn complex on infectivity of lactophages E3, E5 and E17 has been studied. The results of our investigations show that inhibition of lactophage activity by Zn complex of quinolinilporphyrin at concentration 10 microM and 20 microM was in the range 53-62% and 65-85%, respectively. The presence of this porphyrin in nutrient medium prevents the propagation of bacteriophage infection in Lactococcus lactis, but does not affect the phage adsorption process. The free base of quinolinilporphyrin slightly inhibits the activity of lactophages.
authors.affiliation: Biotechnological Scientific-Educational Centre of I.I Mechnikov Odessa National University, Odessa, Ukraine. nsvod@ukr.net
authors.forename: Natalia
authors.initials: N
authors.lastname: Vodzinska
authors.forename: Boris
authors.initials: B
authors.lastname: Galkin
authors.forename: Yuriy
authors.initials: Y
authors.lastname: Ishkov
authors.forename: Anna
authors.initials: A
authors.lastname: Kirichenko
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kondratyuk
authors.forename: Tetiana
authors.initials: T
authors.lastname: Filipova
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001435:Bacteriophages / Q000187:drug effects*; D013294:Lactococcus lactis / Q000821:virology*; D008665:Metalloporphyrins / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*; D011806:Quinolinium Compounds / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D008665:Metalloporphyrins; D011166:Porphyrins; D011806:Quinolinium Compounds; C017802:zinc hematoporphyrin