title: TNF superfamily in inflammatory disease: translating basic insights.
abstract: The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions including promoting cellular differentiation, survival, and production of inflammatory cytokines and chemokines. Emerging data show that TNFSF ligand-receptor signaling pathways are active in inflammatory and autoimmune disease. Furthermore, several genetic polymorphisms in TNFSF and TNFRSF associate with susceptibility to developing disease. Here, we examine recent data regarding the potential of these molecules as targets for therapy of autoimmune and inflammatory disease.
authors.affiliation: La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, La Jolla, CA 92037, USA. mick@liai.org
authors.forename: Michael
authors.initials: M
authors.lastname: Croft
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
authors.forename: Heonsik
authors.initials: H
authors.lastname: Choi
authors.forename: So-Young
authors.initials: SY
authors.lastname: Eun
authors.forename: Shravan
authors.initials: S
authors.lastname: Madireddi
authors.forename: Amit
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D048069:Tumor Necrosis Factors / Q000276:immunology*
chemical_list: D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor; D048069:Tumor Necrosis Factors