title: [Clinical analyses of sudden sensorineural hearing loss in 14 nasopharyngeal carcinomas following radiotherapy].
abstract: OBJECTIVE
  To investigate the clinical characteristics and effects of sudden sensorineural hearing loss in nasopharyngeal carcinoma (NPC) following radiotherapy.
  
  
  METHODS
  The clinical characteristics and effects in 14 NPC patients (15 ears) with sudden sensorineural hearing loss following radiotherapy were retrospectively analyzed.
  
  
  RESULTS
  The sudden sensorineural hearing loss happened more in male subjects than female subjects and more in the left ear than the right ear. Its occurrence time was averaged 6.6 years following radiotherapy. Most of the patients suffered hearing loss prior to the sudden sensorineural hearing loss. The 250, 500, 1000, 2000, 4000 Hz average hearing thresholds: sudden hearing loss ears (78.5 ± 24.7) dBHL, none-sudden hearing loss ears (57.0 ± 32.4) dBHL, among which, 73.33% (11/15) for sensorineural hearing loss, 26.67% (4/15) for mixed hearing loss. 12 cases had complications following radiotherapy. At least one case had posterior circulation barrier. The total effective rate was 26.67% (4/15) and four cases had relapsed and in vain thereafter.
  
  
  CONCLUSIONS
  In NPC patients who received radiotherapy, it caused more serious sudden sensorineural hearing loss and the treatment effects were poor and hearing loss was susceptible to relapse. The pathogenesis may be related to the radiation caused posterior circulation disorders.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: An-zhou
authors.initials: AZ
authors.lastname: Tang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shi-hua
authors.initials: SH
authors.lastname: Yin
authors.forename: Hong-wu
authors.initials: HW
authors.lastname: Cai
authors.forename: Qin
authors.initials: Q
authors.lastname: Fang
authors.forename: Guang-yao
authors.initials: GY
authors.lastname: He
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D002277:Carcinoma; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D003639:Hearing Loss, Sudden / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies