title: Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan.
abstract: Angiogenesis is essential for the growth, invasion, and metastasis of most solid tumors and has become a valuable pharmacological target for cancer prevention and treatment. This study was performed to assess the antiangiogenic activity of 31 medicinal plants grown and sold in Jordan. The antiangiogenic activity was assessed using the rat aortic ring assay. Out of 31 extracts, 15 extracts showed more than 50 % inhibition of the blood vessels outgrowth from the primary tissue explants (p = 0.000). Three of these 15 extracts showed a potential cytotoxic effect on normal fibroblast cells. Four extracts shared antiangiogenic and antiproliferative activity towards MCF7 breast cancer cell lines. Eight extracts demonstrated selective antiangiogenic activity. This is the first report demonstrating the potential antiangiogenic activity of Artemisia judaica, Aloysia citriodora, Salvia egyptiaca, and Calendula arvensis. Some extracts with antiangiogenic activity exhibited selectivity against the endothelial cells proliferation, demonstrating a direct inhibitory activity against the key step in tumor angiogenesis.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Jordan, Amman, Jordan. M.zihlif@ju.edu.jo
authors.forename: Malek
authors.initials: M
authors.lastname: Zihlif
authors.forename: Fatma
authors.initials: F
authors.lastname: Afifi
authors.forename: Ruba
authors.initials: R
authors.lastname: Muhtaseb
authors.forename: Sondos
authors.initials: S
authors.lastname: Al-Khatib
authors.forename: Ismail
authors.initials: I
authors.lastname: Abaza
authors.forename: Randa
authors.initials: R
authors.lastname: Naffa
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects; D019306:Artemisia / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy; D020838:Calendula / Q000737:chemistry; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007597:Jordan; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027544:Salvia / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D010936:Plant Extracts