title: Increased sTREM-1 in pregnant women with premature rupture of membranes             and subclinical chorioamnionitis.
abstract: Premature rupture of membranes (PROM) is a common obstetric complication             frequently occurring with concomitant chorioamnionitis. The present study aimed             to evaluate levels of soluble triggering receptor expressed on myeloid cells-1             (sTREM-1) in serum and amniotic fluid in pregnant women with PROM and to compare             sTREM-1 with the commonly used laboratory indicators, serum C-reactive protein             (CRP) and white blood cell (WBC) count. A total of 55 pregnant women with PROM             were enrolled. Their venous blood and amniotic fluid were collected at delivery.             sTREM-1 concentrations in the serum and amniotic fluid were determined by enzyme-linked             immunosorbent assay. The measured data were compared with the pathological results             of the placenta and fetal membrane. Meanwhile, sTREM-1 was compared with the laboratory             indicators, serum CRP and WBC count. Serum and amniotic fluid sTREM-1 levels were             significantly higher in pregnant women with subclinical chorioamnionitis compared             to pregnant women without chorioamnionitis. Serum concentration of sTREM-1 yielded             a sensitivity of 81.8% and a specificity of 77.3% for the prediction of subclinical             chorioamnionitis. The amniotic fluid concentration of sTREM-1 resulted in a sensitivity             of 81.8% and a specificity of 86.4% for the prediction of subclinical chorioamnionitis.             In conclusion, serum and amniotic fluid sTREM-1 levels may emerge as early biological             indicators for predicting PROM complicated with subclinical chorioamnionitis.             sTREM-1 levels are superior to WBC count in predicting subclinical chorioamnionitis.
authors.affiliation: Department of Gynecology and Obstetrics, The Second Afﬁliated Hospital, Wenzhou, Zhejiang 325035, PR China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
authors.forename: Yiji
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hanqing
authors.initials: H
authors.lastname: Zhang
authors.forename: Wanglei
authors.initials: W
authors.lastname: Qu
authors.forename: Jieqiang
authors.initials: J
authors.lastname: Lv
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D012372:ROC Curve; D011971:Receptors, Immunologic / Q000032:analysis* / Q000097:blood; D012680:Sensitivity and Specificity; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002097:C-Reactive Protein