title: Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response.
abstract: The clinical significance of increased frequency of unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease (NAFLD) is unknown. Serum bilirubin is an endogenous anti-oxidant, and oxidative stress plays an important role in the pathogenesis of NAFLD. In this study, we have documented 25.4% prevalence of unconjugated hyperbilirubinemia in 204 consecutive NAFLD patients. These patients had a significantly less severe liver disease on histopathology and/or fibroScan which may be attributed to anti-oxidant effect of bilirubin.
authors.affiliation: Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi-110070, India. docrameshkr@gmail.com
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Archana
authors.initials: A
authors.lastname: Rastogi
authors.forename: J S
authors.initials: JS
authors.lastname: Maras
authors.forename: Shiv Kumar
authors.initials: SK
authors.lastname: Sarin
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood; D003710:Demography; D054459:Elasticity Imaging Techniques; D005234:Fatty Liver / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000150:complications* / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D012720:Severity of Illness Index
chemical_list: D001663:Bilirubin