title: Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance.
abstract: OBJECTIVE
  Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR.
  
  
  METHODS
  HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n=15) were compared with HTG subjects without IR (WIR) (n=15) and with normotriglyceridemic (NTG)-WIR individuals (n=30).
  
  
  RESULTS
  Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels.
  
  
  CONCLUSIONS
  The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.
authors.affiliation: Laboratory of Lipids of Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Argentina. mulag@hotmail.com
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gómez Rosso
authors.forename: Tomás
authors.initials: T
authors.lastname: Meroño
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giunta
authors.forename: Laura
authors.initials: L
authors.lastname: Boero
authors.forename: Laura
authors.initials: L
authors.lastname: Schreier
authors.forename: Luis
authors.initials: L
authors.lastname: Cuniberti
authors.forename: Fernando
authors.initials: F
authors.lastname: Brites
mesh_terms: D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male
chemical_list: D008055:Lipids; D008074:Lipoproteins