title: Kinetic and reaction pathway analysis in the application of botulinum toxin a for wound healing.
abstract: A relatively new approach in the treatment of specific wounds in animal models and in patients with type A botulinum toxin is the focus of this paper. The indications or conditions include traumatic wounds (experimental and clinical), surgical (incision) wounds, and wounds such as fissures and ulcers that are signs/symptoms of disease or other processes. An objective was to conduct systematic literature searches and take note of the reactions involved in the healing process and identify corresponding pharmacokinetic data. From several case reports, we developed a qualitative model of how botulinum toxin disrupts the vicious cycle of muscle spasm, pain, inflammation, decreased blood flow, and ischemia. We transformed this model into a minimal kinetic scheme for healing chronic wounds. The model helped us to estimate the rate of decline of this toxin's therapeutic effect by calculating the rate of recurrence of clinical symptoms after a wound-healing treatment with this neurotoxin.
authors.affiliation: Integrated Toxicology Division, US Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, MD 21702, USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Lebeda
authors.forename: Zygmunt F
authors.initials: ZF
authors.lastname: Dembek
authors.forename: Michael
authors.initials: M
authors.lastname: Adler