title: Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: possible implications.
abstract: Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies.
authors.affiliation: Department of Pathology, University Hospital Brno, Jihlavska 20, Brno 62500, Czech Republic. lkren@fnbrno.cz
authors.forename: Leos
authors.initials: L
authors.lastname: Kren
authors.forename: Pavel
authors.initials: P
authors.lastname: Fabian
authors.forename: Ondrej
authors.initials: O
authors.lastname: Slaby
authors.forename: Andrea
authors.initials: A
authors.lastname: Janikova
authors.forename: Ondrej
authors.initials: O
authors.lastname: Soucek
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Sterba
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Krenova
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Michalek
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Kral
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D046888:Tissue Array Analysis; D055815:Young Adult; D000097625:HLA-E Antigens
chemical_list: D014408:Biomarkers, Tumor; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens