title: Polymeric nanomaterials for islet targeting and immunotherapeutic delivery.
abstract: Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.
authors.affiliation: Vascular Biology Program, Departments of Pathology and Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Kaustabh
authors.initials: K
authors.lastname: Ghosh
authors.forename: Mathumai
authors.initials: M
authors.lastname: Kanapathipillai
authors.forename: Netanel
authors.initials: N
authors.lastname: Korin
authors.forename: Jason R
authors.initials: JR
authors.lastname: McCarthy
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ingber
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007167:Immunotherapy / Q000379:methods*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D007166:Immunosuppressive Agents; D053769:Nanocapsules; D011108:Polymers