title: Obstructive sleep apnea and P300 evoked auditory potential.
abstract: The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction.
  
  
  OBJECTIVE
  To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients.
  
  
  METHODS
  Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%.
  
  
  RESULTS
  AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89).
  
  
  CONCLUSIONS
  The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory.
authors.affiliation: Depto de Fonoaudiologia, Fac de Odontologia, UNESP.
authors.forename: Carlos Henrique
authors.initials: CH
authors.lastname: Martins
authors.forename: Ney de
authors.initials: Nd
authors.lastname: Castro Júnior
authors.forename: Orozimbo Alves
authors.initials: OA
authors.lastname: Costa Filho
authors.forename: Osmar Mesquita de
authors.initials: OM
authors.lastname: Souza Neto
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D011930:Reaction Time; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*; D012913:Snoring / Q000503:physiopathology*; D055815:Young Adult