title: Changes of the sphincter of Oddi motility in dog after cholecystectomy.
abstract: OBJECTIVE
  To determine the effect of cholecystectomy on the motility of the sphincter of Oddi (SO).
  
  
  METHODS
  Pressures of common bile duct (CBD), SO motility and its response to bolus injections of cholecystokinin (CCK, 20 ng/kg and 100 ng/kg) were detected respectively by manometry in eight Beagle dogs before and after cholecystectomy.
  
  
  RESULTS
  After cholecystectomy the CBD pressure increased 2.18 ± 1.86 mmHg, while the cyclical motion pattern of SO still existed but with a shortened cycle duration. The basal pressure (BP), phasic contraction amplitude (PCA), phasic contraction frequency (PCF) and its mode of propagation did not change significantly. Under the stimulation of CCK after cholecystectomy, although the motion patterns of SO were similar to those before cholecystectomy, the greatest inhibitory efficacy of BP and PCA all decreased with the prolonged excitement duration and the increased percentage of retrograde contraction.
  
  
  CONCLUSIONS
  Shortly after a cholecystectomy in Beagle dogs, the CBD pressure increased, SO motilities did not change significantly during the interdigestive phase except with a shortened cycle duration. Its relaxation responded to CCK was weakened with a confused contraction pattern.
authors.affiliation: Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Ming Ming
authors.initials: MM
authors.lastname: Fan
authors.forename: Fu
authors.initials: F
authors.lastname: Li
authors.forename: Xi Wen
authors.initials: XW
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology; D002763:Cholecystectomy / Q000009:adverse effects*; D002766:Cholecystokinin / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D008365:Manometry; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D011312:Pressure; D009803:Sphincter of Oddi / Q000503:physiopathology*; D046628:Sphincter of Oddi Dysfunction / Q000209:etiology* / Q000503:physiopathology*; D014945:Wound Healing / Q000502:physiology
chemical_list: D002756:Cholagogues and Choleretics; D002766:Cholecystokinin