title: Dissolution studies and quantification of meloxicam in tablet dosage form by spectrophotometry.
abstract: Two simple and inexpensive UV spectrophotometric methods were developed for the quantification and dissolution studies of meloxicam in tablet dosage forms. Meloxicam was estimated at 365nm and 360nm in Method I and Method II, respectively. The calibration curve was linear over a concentration range from 2.0 to 12.0μg/ml for both methods. The limit of detection and limit of quantitation were found to be 0.12μg/ml and 0.38μg/ml, 0.09μg/ml and 0.27μg/ml for Method I and Method II, respectively. The percentage recoveries of meloxicam were found to be 99.68 to 100.61% and 99.11 to 100.96% for Method I and Method II, respectively. It was concluded that the developed methods are precise, accurate and were successfully applied for the estimation of meloxicam in pharmaceutical formulations and in vitro dissolution studies.
authors.affiliation: Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Secunderabad, Andhra Pradesh, India. msreddyinduri@yahoo.com
authors.forename: Madhusudhanareddy
authors.initials: M
authors.lastname: Induri
authors.forename: Bhagavan Raju
authors.initials: BR
authors.lastname: Mantripragada
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Yejella
authors.forename: Pavankumar Reddy
authors.initials: PR
authors.lastname: Kunda
authors.forename: Dharma Theja
authors.initials: DT
authors.lastname: Nannapaneni
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Boddu
mesh_terms: D000077239:Meloxicam; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013607:Tablets / Q000737:chemistry*; D013843:Thiazines / Q000032:analysis* / Q000737:chemistry*; D013844:Thiazoles / Q000032:analysis* / Q000737:chemistry*
chemical_list: D013607:Tablets; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam