title: Association of CYP2C19*3 gene polymorphism with breast  cancer in Chinese women.
abstract: Cytochrome P450 (CYP) 2C19 metabolizes arachidonic  acid to biologically active epoxyeicosatrienoic acids, which significantly  promote proliferation of cancer cells in vitro and in vivo. We  looked for a possible association between human CYP2C19*3 gene polymorphism and  breast cancer in the Chinese Han population. In a Chinese Han case-control  study of breast cancer patients (N = 600) and age- and gender-matched healthy  controls (N = 600), we investigated polymorphism in the CYP2C19 gene by  PCR-RFLP analysis. The CYP2C19*3 AG + AA genotype was significantly more  prevalent in breast cancer patients than in control subjects (6.67 vs 3.00%;  P = 0.003). The odds ratio for carriers of AG + AA genotype for breast cancer  was 2.31 (95% confidence interval = 1.27-4.43). Among patients, estrogen  receptor, tumor size, histologic grade, presence of primary lymphonode metastases,  progesterone receptor positivity, and age at diagnosis were not found to be  significantly associated with CYP2C19*3 genotypes (all P > 0.05). We  conclude that the CYP2C19*3 gene polymorphism is associated with breast cancer  risk in Chinese Han women.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Gan
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
authors.forename: Y D
authors.initials: YD
authors.lastname: Cao
authors.forename: W X
authors.initials: WX
authors.lastname: Ye
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Sun
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D065731:Cytochrome P-450 CYP2C19; D003710:Demography; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19