title: Model transcriptional networks with continuously varying expression levels.
abstract: BACKGROUND
  At a time when genomes are being sequenced by the hundreds, much attention has shifted from identifying genes and phenotypes to understanding the networks of interactions among genes. We developed a gene network developmental model expanding on previous models of transcription regulatory networks. In our model, each network is described by a matrix representing the interactions between transcription factors, and a vector of continuous values representing the transcription factor expression in an individual.
  
  
  RESULTS
  In this work we used the gene network model to look at the impact of mating as well as insertions and deletions of genes in the evolution of complexity of these networks. We found that the natural process of diploid mating increases the likelihood of maintaining complexity, especially in higher order networks (more than 10 genes). We also show that gene insertion is a very efficient way to add more genes to a network as it provides a much higher chance of developmental stability.
  
  
  CONCLUSIONS
  The continuous model affords a more complete view of the evolution of interacting genes. The notion of a continuous output vector also incorporates the reality of gene networks and graded concentrations of gene products.
authors.affiliation: Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. carneiro@gmail.com
authors.forename: Mauricio O
authors.initials: MO
authors.lastname: Carneiro
authors.forename: Clifford H
authors.initials: CH
authors.lastname: Taubes
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Hartl
mesh_terms: D003198:Computer Simulation; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D016254:Mutagenesis, Insertional; D017384:Sequence Deletion