title: Acute myeloid leukemia with myelodysplasia-related changes mimicking acute promyelocytic leukemia.
abstract: We describe a patient with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) that clinically resembled acute promyelocytic leukemia (APL). The karyotype of his leukemic cells was 46, XY, del (3) (q?) and did not include a chromosomal translocation involving the retinoic acid receptor-α gene. However, retinoic acid syndrome developed, and partial remission was achieved after treatment with all-trans retinoic acid (ATRA) followed by chemotherapy. Our case might provide new insights into the mechanism of the growth inhibitory effect of ATRA on APL-like cells.
authors.affiliation: Division of Pulmonary Medicine, National Hospital Organization National Kochi Hospital, Japan. machidah@Kochi2.hosp.go.jp
authors.forename: Hisanori
authors.initials: H
authors.lastname: Machida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shinohara
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Iwahara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okano
authors.forename: Mayuri
authors.initials: M
authors.lastname: Nakano
authors.forename: Emiko
authors.initials: E
authors.lastname: Hosokawa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Keishi
authors.initials: K
authors.lastname: Naruse
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ogushi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014212:Tretinoin