title: Neural circuits underlying the pathophysiology of mood disorders.
abstract: Although mood disorders constitute leading causes of disability, until recently little was known about their pathogenesis. The delineation of anatomical networks that support emotional behavior (mainly derived from animal studies) and the development of neuroimaging technologies that allow in vivo characterization of anatomy, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). In this review, we integrate insights from human and animal studies, which collectively suggest that MDD and BD involve dysfunction within an extended network including the medial prefrontal cortex and anatomically-related limbic, striatal, thalamic and basal forebrain structures.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA. pricej@wustl.edu
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Price
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000503:physiopathology*; D009445:Neuroanatomy; D059906:Neuroimaging; D017397:Prefrontal Cortex / Q000503:physiopathology*