title: Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative.
abstract: In pursuit of a single molecule with potential applications for both in vitro fluorescence microscopy and in vivo PET imaging, novel targeted (69/71)Ga/(68)Ga-protoporphyrin IX (PPIX) probes were developed. Optical analysis, fluorescence microscopy and radiolabeling with gallium-68 were performed to confirm potential applications. The use of a targeted-PPIX ring, in conjunction with (69/71)Ga or (68)Ga, eliminates the need for the attachment of multiple imaging tags, allowing for either in vitro fluorescent-based evaluation or in vivo nuclear-based imaging.
authors.affiliation: Department of Chemistry, The University of Western Ontario, London, Canada.
authors.forename: Babak Behnam
authors.initials: BB
authors.lastname: Azad
authors.forename: Choi-Fong
authors.initials: CF
authors.lastname: Cho
authors.forename: John D
authors.initials: JD
authors.lastname: Lewis
authors.forename: Leonard G
authors.initials: LG
authors.lastname: Luyt
mesh_terms: D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D008856:Microscopy, Fluorescence; D049268:Positron-Emission Tomography; D011524:Protoporphyrins / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D011524:Protoporphyrins; D011868:Radioisotopes; C028025:protoporphyrin IX