title: A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.
abstract: Triglyceride (TG) is a complex phenotype influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels; however, such studies in Chinese populations are limited. A two-stage GWAS were conducted to identify genetic variants that were associated with TG in a Chinese population of 3495 men. Gene-environment interactions on serum TG levels were further investigated for the seven single nucleotide polymorphisms (SNPs) that were studied in both stages. Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 × 10(-26) and 1.41 × 10(-9) for rs651821 and rs328, respectively. More importantly, a significant interaction between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol consumption on serum TG levels were observed (P = 3.34 × 10(-5)). Rs671 was significantly associated with serum TG levels in drinkers (P = 1.90 × 10(-10)), while no association was observed in non-drinkers (P > 0.05). For drinkers, men carrying the AA/AG genotype have significantly lower serum TG levels, compared with men carrying the GG genotype. For men with the GG genotype, the serum TG levels increased with the quantity of alcohol intake (P = 1.28 × 10(-8) for trend test). We identified a novel, significant interaction effect between alcohol consumption and the ALDH2 rs671 polymorphism on TG levels, which suggests that the effect of alcohol intake on TG occurs in a two-faceted manner. Just one drink can increase TG level in susceptible individuals who carry the GG genotype, while individuals carrying AA/AG genotypes may actually benefit from moderate drinking.
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Tan
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: Ning
authors.initials: N
authors.lastname: Xia
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.forename: Shijun
authors.initials: S
authors.lastname: Zhang
authors.forename: Sha
authors.initials: S
authors.lastname: Tao
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhang
authors.forename: Seong-Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Linjian
authors.initials: L
authors.lastname: Mo
authors.forename: Zhengjia
authors.initials: Z
authors.lastname: Liang
authors.forename: Deyi
authors.initials: D
authors.lastname: Shi
authors.forename: Zhang
authors.initials: Z
authors.lastname: Huang
authors.forename: Xianghua
authors.initials: X
authors.lastname: Huang
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D002681:China; D059647:Gene-Environment Interaction; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D014280:Triglycerides; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial