title: [A case of an elderly breast cancer patient achieving partial response with toremifene without efficacy of letrozole as a preoperative primary endocrine therapy].
abstract: A 91-year-old woman was diagnosed as having ER-positive breast cancer, and was treated with primary endocrine therapy because she refused to undergo surgery under general anesthesia. The patient was treated with letrozole as the initial endocrine therapy, but was judged to have progressive disease after 11 months. During letrozole treatment, the patient could not achieve an effect greater than stable disease. Thereafter, she received toremifene treatment (40 mg/day). After three months of this treatment, the patient achieved a partial response. The response was maintained for 12 months, and the patient then underwent lumpectomy under local anesthesia. In conclusion, toremifene could be an effective preoperative primary endocrine regimen for elderly breast cancer patients.
authors.affiliation: Dept. of Surgery, Sakai Municipal Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Arai
authors.forename: Chiya
authors.initials: C
authors.lastname: Ooshiro
authors.forename: Shunji
authors.initials: S
authors.lastname: Kamigaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miwa
authors.forename: Genichirou
authors.initials: G
authors.lastname: Yoneda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Harada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D000077289:Letrozole; D020360:Neoadjuvant Therapy; D009570:Nitriles / Q000627:therapeutic use; D016879:Salvage Therapy; D017312:Toremifene / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D017312:Toremifene