title: Intraventricular hemorrhage in preterm infants: coagulation perspectives.
abstract: It has long been considered that a severe coagulation deficiency in premature newborns could be a major contributing factor in the occurrence of intraventricular hemorrhage (IVH). High-grade IVH has also been shown to coincide with severe derangement of coagulation in extremely low birth weight infants. This review focuses on the relevance of the physiologically developing immature hemostatic system to IVH, and the potential benefit of agents affecting hemostasis for IVH therapy or prevention in preterm infants. The findings of small, open-label interventional studies on the effect of ethamsylate, vitamin K, fresh frozen plasma, recombinant activated factor VII, and prothrombin complex concentrate on the premature coagulation system will be reviewed.
authors.affiliation: Pediatric Hematology Clinic, Thrombosis and Hemostasis Service, Institute of Hematology, Western Galilee Hospital, Naharriya, Israel.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Kuperman
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Papadakis
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brenner
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000517:prevention & control*; D004979:Ethamsylate / Q000627:therapeutic use; D015942:Factor VIIa / Q000627:therapeutic use; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control*; D010949:Plasma; D014463:Ultrasonography; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D001779:Blood Coagulation Factors; D014812:Vitamin K; D004979:Ethamsylate; C025667:prothrombin complex concentrates; D015942:Factor VIIa