title: Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella henselae.
abstract: Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The aim of this study was to investigate the influence of Borrelia afzelii, Coxiella burnetii, and Bartonella henselae bacteria on apoptosis measured as the level of caspase 3 activity in human fibroblast cells HEL-299. Our findings show that C. burnetii bacteria may inhibit the process of apoptosis in the host cells for a long time. This can permit intracellular survival in the host and mediatingthe development of chronic disease.
authors.affiliation: Laboratory of Rickettsiae, Chlamydiae and Spirochetes, National Institute of Public Health, Natonal Institute of Hygiene, Warsaw, Poland. tchmielewski@pzh.gov.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Chmielewski
authors.forename: Stanisława
authors.initials: S
authors.lastname: Tylewska-Wierzbanowska
mesh_terms: D017209:Apoptosis; D018416:Bartonella henselae / Q000472:pathogenicity*; D015748:Borrelia burgdorferi Group / Q000472:pathogenicity*; D053148:Caspase 3 / Q000378:metabolism; D002478:Cells, Cultured; D016997:Coxiella burnetii / Q000472:pathogenicity*; D005347:Fibroblasts / Q000201:enzymology / Q000502:physiology; D006801:Humans
chemical_list: D053148:Caspase 3