title: Deep infiltrating endometriosis is a determinant factor of cumulative pregnancy rate after intracytoplasmic sperm injection/in vitro fertilization cycles in patients with endometriomas.
abstract: OBJECTIVE
  To evaluate the cumulative pregnancy rate (CPR) per patient after in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles in patients with endometriomas and to evaluate the determinant factors of CPR per patient.
  
  
  METHODS
  Retrospective study from January 2007 to October 2008.
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  103 patients who had undergone IVF treatment, comprising isolated endometriomas (n = 30) and endometriomas with associated deep infiltrating endometriosis (DIE) (n = 73).
  
  
  METHODS
  None.
  
  
  METHODS
  Clinical pregnancy rate after IVF-ICSI cycle.
  
  
  RESULTS
  The total number of cycles was 162, and the median number of cycles per patient was 1 (1 to 5). Fifty-eight women (56.3%) became pregnant. The total number of endometriomas and size of the largest endometrioma and bilateral endometriomas had no impact on the CPR per patient. Using multivariable analysis, the associated DIE and antimüllerian hormone serum level (≤ 1 ng/mL) were independent factors associated with a decrease in the pregnancy rate per patient. Overall, the CPR per patient was 73.7%, and it increased until the third cycle with no benefit for additional cycles. The CPR per patient for women with isolated endometriomas and women with endometriomas and associated DIE was 82.5% and 69.4%, respectively.
  
  
  CONCLUSIONS
  Associated DIE has a negative impact on assisted reproduction results in patients with endometriomas. Moreover, our data show that after three IVF-ICSI cycles the CPR per patient is not improved and that surgery should be considered.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ballester
authors.forename: Anne
authors.initials: A
authors.lastname: Oppenheimer
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Mathieu d'Argent
authors.forename: Cyril
authors.initials: C
authors.lastname: Touboul
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Antoine
authors.forename: Michelle
authors.initials: M
authors.lastname: Nisolle
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D004715:Endometriosis / Q000150:complications / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D010297:Paris; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D055815:Young Adult