title: Differences in motor and cognitive function in patients with Parkinson's disease with and without orthostatic hypotension.
abstract: Patients with Parkinson's disease (PD) often present with orthostatic hypotension (OH) as a result of the dysautonomia associated with the disease or as a side effect of the dopaminergic medications used to treat the disease. The purpose of this study was to investigate differences in motor and cognitive function in patients with PD with and without OH. Forty-four patients with a diagnosis of PD were evaluated and stratified by the presence of OH based on orthostatic blood pressure recordings. Both groups underwent assessments of motor and cognitive function. OH was present in 17 of 44 patients (39%) with PD. These patients with OH had significantly lower scores in gross motor, balance, and cognitive function (p < .05). No significant difference between groups was found in the finger tapping scores. These results suggest that patients with PD should be routinely screened for OH as it commonly occurs and may negatively impact gross motor, balance, and cognitive function.
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston, MA, USA. hohlera@hotmail.com
authors.forename: Anna D
authors.initials: AD
authors.lastname: Hohler
authors.forename: José-Rafael P
authors.initials: JR
authors.lastname: Zuzuárregui
authors.forename: Douglas I
authors.initials: DI
authors.lastname: Katz
authors.forename: T Joy
authors.initials: TJ
authors.lastname: Depiero
authors.forename: Christina L
authors.initials: CL
authors.lastname: Hehl
authors.forename: Alissa
authors.initials: A
authors.lastname: Leonard
authors.forename: Valerie
authors.initials: V
authors.lastname: Allen
authors.forename: Jill
authors.initials: J
authors.lastname: Dentino
authors.forename: Maura
authors.initials: M
authors.lastname: Gardner
authors.forename: Heidi
authors.initials: H
authors.lastname: Phenix
authors.forename: Marie
authors.initials: M
authors.lastname: Saint-Hilaire
authors.forename: Terry
authors.initials: T
authors.lastname: Ellis
mesh_terms: D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology* / Q000534:rehabilitation; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000534:rehabilitation; D004856:Postural Balance / Q000502:physiology