title: A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults.
abstract: We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. No differences were observed in genotype prevalence or minor allele frequencies between persons with fatal influenza and the reference sample. Fatal cases with low-producing MBL2 genotypes had a 7-fold increased risk for invasive methicillin-resistant Staphylococcus aureus (MRSA) co-infection compared with fatal cases with high- and intermediate-producing MBL2 genotypes (odds ratio 7.1, 95% confidence interval 1.6-32.1). Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. Among children and young adults who died of influenza, low-producing MBL2 genotypes may have increased risk for MRSA co-infection.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. zdn5@cdc.gov
authors.forename: Jill M
authors.initials: JM
authors.lastname: Ferdinands
authors.forename: Amy M
authors.initials: AM
authors.lastname: Denison
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Dowling
authors.forename: Heather A
authors.initials: HA
authors.lastname: Jost
authors.forename: Marta L
authors.initials: ML
authors.lastname: Gwinn
authors.forename: Lindy
authors.initials: L
authors.lastname: Liu
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
authors.forename: David K
authors.initials: DK
authors.lastname: Shay
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000235:genetics / Q000401:mortality; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000150:complications / Q000235:genetics* / Q000401:mortality*; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000150:complications / Q000235:genetics / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D014409:Tumor Necrosis Factor-alpha