title: TOR-autophagy signaling in adult zebrafish models of cardiomyopathy.
abstract: The target of rapamycin (TOR) kinase is part of an evolutionarily conserved signaling pathway that coordinates cell growth, survival, and autophagy. Previously, pharmacological studies using rapamycin have suggested a cardioprotective effect of TOR signaling inhibition on cardiomyopathy. We found that rapamycin exerts a conserved cardioprotective effect in two adult zebrafish models of cardiomyopathy of different etiology, and provided the first genetic evidence to support a long-term cardioprotective effect of TOR signaling inhibition. Moreover, we detected dynamic TOR-autophagy activities along different stages of cardiomyopathy. This needs to be considered when developing TOR-autophagy-based therapeutics for cardiomyopathy.
authors.affiliation: Department of Biochemistry and Molecular Biology/Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Yonghe
authors.initials: Y
authors.lastname: Ding
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Sun
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Xu
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001343:Autophagy; D009202:Cardiomyopathies / Q000201:enzymology* / Q000473:pathology*; D002316:Cardiotonic Agents / Q000378:metabolism; D004195:Disease Models, Animal; D004317:Doxorubicin; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D002316:Cardiotonic Agents; D004317:Doxorubicin; D058570:TOR Serine-Threonine Kinases