title: Vitamin K status in peritoneally dialyzed patients with chronic kidney disease.
abstract: Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p< 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.
authors.affiliation: Department of Internal Medicine, Metabolism and Dietetics, Poznań University of Medical Sciences, Poznań, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Stankowiak-Kulpa
authors.forename: Patrycja
authors.initials: P
authors.lastname: Krzyżanowska
authors.forename: Lidia
authors.initials: L
authors.lastname: Kozioł
authors.forename: Marian
authors.initials: M
authors.lastname: Grzymisławski
authors.forename: Maria
authors.initials: M
authors.lastname: Wanic-Kossowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Moczko
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000032:analysis / Q000378:metabolism; D003404:Creatinine / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000032:analysis / Q000378:metabolism*; D011516:Prothrombin / Q000032:analysis / Q000378:metabolism*; D012307:Risk Factors; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism; D014812:Vitamin K / Q000032:analysis / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D011498:Protein Precursors; D014280:Triglycerides; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin; D003404:Creatinine