title: Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy.
abstract: The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent intensities of the FL-SBL-labeled DSPC liposomes increased with the increase of the additive FL-SBL, and the maximum emission wavelength of the liposomes appeared at 531 nm. A preliminary in vivo imaging study of tumor-bearing mice revealed that the FL-SBL-labeled DSPC liposomes were delivered to the tumor tissue but not distributed to hypoxic regions.
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo, 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Ueda
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.forename: Manabu
authors.initials: M
authors.lastname: Ueno
authors.forename: Shoji
authors.initials: S
authors.lastname: Tachikawa
mesh_terms: D000818:Animals; D001895:Boron / Q000008:administration & dosage* / Q000737:chemistry; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D005260:Female; D005453:Fluorescence; D008081:Liposomes / Q000008:administration & dosage* / Q000138:chemical synthesis*; D051379:Mice; D009369:Neoplasms / Q000532:radiotherapy*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013228:Stearates / Q000138:chemical synthesis* / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D001896:Boron Compounds; D008081:Liposomes; D010069:Oxadiazoles; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D013228:Stearates; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; C119788:dodecaborate; D011092:Polyethylene Glycols; C010942:1,2-distearoyllecithin; D001895:Boron