title: The impact of focused Gene Ontology curation of specific mammalian systems.
abstract: The Gene Ontology (GO) resource provides dynamic controlled vocabularies to provide an information-rich resource to aid in the consistent description of the functional attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). System-focused projects, such as the Renal and Cardiovascular GO Annotation Initiatives, aim to provide detailed GO data for proteins implicated in specific organ development and function. Such projects support the rapid evaluation of new experimental data and aid in the generation of novel biological insights to help alleviate human disease. This paper describes the improvement of GO data for renal and cardiovascular research communities and demonstrates that the cardiovascular-focused GO annotations, created over the past three years, have led to an evident improvement of microarray interpretation. The reanalysis of cardiovascular microarray datasets confirms the need to continue to improve the annotation of the human proteome.
  
  
  BACKGROUND
  GO ANNOTATION DATA IS FREELY AVAILABLE FROM: ftp://ftp.geneontology.org/pub/go/gene-associations/
authors.affiliation: EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Alam-Faruque
authors.forename: Rachael P
authors.initials: RP
authors.lastname: Huntley
authors.forename: Varsha K
authors.initials: VK
authors.lastname: Khodiyar
authors.forename: Evelyn B
authors.initials: EB
authors.lastname: Camon
authors.forename: Emily C
authors.initials: EC
authors.lastname: Dimmer
authors.forename: Tony
authors.initials: T
authors.lastname: Sawford
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Martin
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.forename: Philippa J
authors.initials: PJ
authors.lastname: Talmud
authors.forename: Peter
authors.initials: P
authors.lastname: Scambler
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Lovering
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007668:Kidney / Q000254:growth & development / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008322:Mammals / Q000235:genetics*; D058977:Molecular Sequence Annotation / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D013223:Statistics as Topic