title: [Phagocyte migration: an overview].
abstract: Phagocytes are the first line of host defense thanks to their capacity to infiltrate infected and wounded tissues, where they exert their bactericidal and tissue repair functions. However, tissue infiltration of phagocytes also stimulates the progression of pathologies such as cancer and chronic inflammatory diseases. It is therefore necessary to identify the molecular and cellular mechanisms that control this process to identify new therapeutic targets. Phagocytes leave the blood stream by crossing the vascular wall and infiltrate interstitial tissues, a three-dimensional environment. A state-of-the-art of the different steps of phagocyte tissue recruitment in vivo and of the different in vitro models is developed in this synthesis. We focus on recent data concerning the migration of phagocytes in three-dimensional environments. The use of two different migration modes, amoeboid and mesenchymal, by macrophages and the role of podosomes and proteases in the mesenchymal migration are discussed.
authors.affiliation: CNRS, UMR 5089, Institut de Pharmacologie et de Biologie Structurale, 205, route de Narbonne, BP 64182, F-31077 Toulouse Cedex 4, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Le Cabec
authors.forename: Emeline
authors.initials: E
authors.lastname: Van Goethem
authors.forename: Romain
authors.initials: R
authors.lastname: Guiet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Maridonneau-Parini
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D008954:Models, Biological; D020556:Neutrophil Infiltration / Q000235:genetics / Q000502:physiology; D010586:Phagocytes / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D057705:Transendothelial and Transepithelial Migration / Q000235:genetics / Q000502:physiology