title: A case study of a patient with gliosarcoma with an extended survival and spinal cord metastases.
abstract: Gliosarcoma is a rare brain tumor consisting of both glial and mesenchymal components. Metastatic gliosarcoma is rare; however, here we report a 31-year-old Chinese woman with cranial gliosarcoma metastatic to the liver, lymph nodes and the spinal cord. Initially, the patient presented with dizziness, headache and vomiting and after surgery and histological examination, was diagnosed with cranial gliosarcoma. The patient was treated with surgical resection followed by chemotherapy and radiotherapy. Three years after completing treatment, the patient again presented with similar symptoms with the addition of a seizure. Test revealed recurrence of the gliosarcoma, and the same treatment was prescribed. Three years after treatment completion, the patient again presented with dizziness and headache. Masses at the right temple and in the right side of the neck were found. Tumors were surgically removed from the brain, skull, scalp and neck, the latter three diagnosed as metastatic gliosarcomas. The patient received both chemotherapy and radiotherapy following resection. One month after treatment, bone scans revealed possible metastasis in the right skull, lumbar and left ileum, soft neck tissue, lungs, collarbone, humeri, vertebrae, liver and abdominal lymph nodes. No further therapy was recommended due to the poor condition of the patient. The patient died 5 months later.
authors.affiliation: Department of Neurosurgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10#, Changjiang Branch, Daping, Yuzhong District, Chongqing 400042, People's Republic of China.
authors.forename: LiZhao
authors.initials: L
authors.lastname: Chen
authors.forename: HuaLiang
authors.initials: H
authors.lastname: Xiao
authors.forename: Lunshan
authors.initials: L
authors.lastname: Xu
authors.forename: YongWen
authors.initials: Y
authors.lastname: Zou
authors.forename: YunDong
authors.initials: Y
authors.lastname: Zhang
authors.forename: MinHui
authors.initials: M
authors.lastname: Xu
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D005260:Female; D018316:Gliosarcoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging; D012008:Recurrence; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D014057:Tomography, X-Ray Computed