title: [OsteoLaus: prediction of osteoporotic fractures by clinical risk factors and DXA, IVA and TBS].
abstract: OsteoLaus is a cohort of 1400 women 50 to 80 years living in Lausanne, Switzerland. Clinical risk factors for osteoporosis, bone ultrasound of the heel, lumbar spine and hip bone mineral density (BMD), assessment of vertebral fracture by DXA, and microarchitecture evaluation by TBS (Trabecular Bone Score) will be recorded. TBS is a new parameter obtained after a re-analysis of a DXA exam. TBS is correlated with parameters of microarchitecture. His reproducibility is good. TBS give an added diagnostic value to BMD, and predict osteoporotic fracture (partially) independently to BMD. The position of TBS in clinical routine in complement to BMD and clinical risk factors will be evaluated in the OsteoLaus cohort.
authors.affiliation: Service de médecine interne, Départment de médecine, CHUV, 1011 Lausanne. olivier.lamy@chuv.ch
authors.forename: O
authors.initials: O
authors.lastname: Lamy
authors.forename: M
authors.initials: M
authors.lastname: Metzger
authors.forename: M-A
authors.initials: MA
authors.lastname: Krieg
authors.forename: B
authors.initials: B
authors.lastname: Aubry-Rozier
authors.forename: D
authors.initials: D
authors.lastname: Stoll
authors.forename: D
authors.initials: D
authors.lastname: Hans
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis; D015331:Cohort Studies; D003196:Computer Graphics; D005260:Female; D006365:Heel / Q000000981:diagnostic imaging; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D058866:Osteoporotic Fractures / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013557:Switzerland; D014463:Ultrasonography