title: Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial.
abstract: In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA 98104, USA. jbaeten@uw.edu
authors.forename: Jared M
authors.initials: JM
authors.lastname: Baeten
authors.forename: Stewart E
authors.initials: SE
authors.lastname: Reid
authors.forename: Sinead
authors.initials: S
authors.lastname: Delany-Moretlwe
authors.forename: James P
authors.initials: JP
authors.lastname: Hughes
authors.forename: Richard S
authors.initials: RS
authors.lastname: Wang
authors.forename: Ellen
authors.initials: E
authors.lastname: Wilcox
authors.forename: Mohammed
authors.initials: M
authors.lastname: Limbada
authors.forename: Godspower
authors.initials: G
authors.lastname: Akpomiemie
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
authors.forename: Connie
authors.initials: C
authors.lastname: Celum
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000235:genetics; D004311:Double-Blind Method; D005260:Female; D018023:HIV Seronegativity; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D012008:Recurrence; D016036:Seroepidemiologic Studies; D013019:South Africa / Q000453:epidemiology; D014456:Ulcer / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D017201:Virus Shedding / Q000187:drug effects; D015024:Zambia / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir