title: c-Cbl targets active Src for autophagy.
abstract: Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src.
authors.affiliation: Dulbecco Telethon Institute, Department of Biology, University of Tor Vergata, 00133 Rome, Italy. francesco.cecconi@uniroma2.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cecconi
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D008297:Male; D019061:src-Family Kinases / Q000378:metabolism*
chemical_list: D051417:Focal Adhesion Kinase 1; C496051:Ptk2 protein, mouse; D019061:src-Family Kinases