title: Viperin, a key player in the antiviral response.
abstract: Viperin is an antiviral protein that is induced by different viruses, type I interferon, poly(I:C) and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets. Recently, our knowledge on the mechanism by which viperin inhibits viral replication has strongly increased. Interestingly, it also became clear that viperin can be used by viruses to increase their infectivity. Here, our current knowledge on the induction of viperin and its effect on virus replication will be reviewed.
authors.affiliation: Department of Biomolecular Chemistry-271, Nijmegen Center for Molecular Life Sciences and Institute for Molecules and Materials, Radboud University Nijmegen, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.
authors.forename: Sandy
authors.initials: S
authors.lastname: Mattijssen
authors.forename: Ger J M
authors.initials: GJ
authors.lastname: Pruijn
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism; D006801:Humans; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology*; D014779:Virus Replication; D000090123:Viperin Protein
chemical_list: D000998:Antiviral Agents; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins; C417529:Rsad2 protein, mouse; D000090123:Viperin Protein; C444427:RSAD2 protein, human