title: Secondary metabolism in simulated microgravity and space flight.
abstract: Space flight experiments have suggested that microgravity can affect cellular processes in microorganisms. To simulate the microgravity environment on earth, several models have been developed and applied to examine the effect of microgravity on secondary metabolism. In this paper, studies of effects of space flight on secondary metabolism are exemplified and reviewed along with the advantages and disadvantages of the current models used for simulating microgravity. This discussion is both significant and timely to researchers considering the use of simulated microgravity or space flight to explore effects of weightlessness on secondary metabolism.
authors.affiliation: Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D006801:Humans; D008660:Metabolism / Q000502:physiology*; D008962:Models, Theoretical; D013026:Space Flight; D018474:Weightlessness Simulation