title: Molecular epidemiology of Rift Valley fever virus.
abstract: Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
authors.affiliation: National Institute for Communicable Diseases of the National Health Service, Sandringham, South Africa.
authors.forename: Antoinette A
authors.initials: AA
authors.lastname: Grobbelaar
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Weyer
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Leman
authors.forename: Alan
authors.initials: A
authors.lastname: Kemp
authors.forename: Janusz T
authors.initials: JT
authors.lastname: Paweska
authors.forename: Robert
authors.initials: R
authors.lastname: Swanepoel
mesh_terms: D000818:Animals; D001483:Base Sequence; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks / Q000662:veterinary; D005814:Genes, Viral; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D011995:Recombination, Genetic; D012295:Rift Valley Fever / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D012296:Rift Valley fever virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012418:Ruminants; D012529:Saudi Arabia / Q000453:epidemiology; D013019:South Africa / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics; D014765:Viral Vaccines / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins; D014765:Viral Vaccines