title: Are proton pump inhibitors a new antidiabetic drug? A cross sectional study.
abstract: OBJECTIVE
  To investigate the effect of proton pump inhibitors (PPIs) on glycemic control (HbA1c) in type 2 diabetic patients.
  
  
  METHODS
  A cross-sectional study of consecutive in-patients admitted to hospital in any department during the first semester of the year 2010 who had a recent HbA1c measurement. The study excluded those with a diagnosis of hyperglycemic decompensation, diabetic onset or pregnancy. It compared HbA1c levels of those taking PPIs and those not.
  
  
  RESULTS
  A total of 97 patients were recruited. The average HbA1C level was 7.0% ± 1.2%. Overall PPI consumption was 55.7%. HbA1c was significantly lower in individuals who took PPIs: -0.6%, 95% CI: -0.12 to -0.83. People who used PPIs with some type of insulin therapy had a HbA1c reduction by -0.8%, 95% CI: -0.12 to -1.48. For the rest of subgroup analysis based on the antidiabetic drug used, PPI consumption always exhibited lower HbA1c levels.
  
  
  CONCLUSIONS
  PPIs seems to be consistently associated with better glycemic control in type 2 diabetes. HbA1c reduction observed is similar to incretin-based therapies.
authors.affiliation: Diana Boj-Carceller, Alejandro Sanz-Paris, Pablo Trincado- Aznar, Ramón Albero-Gamboa, Endocrinology and Nutrition Unit, Hospital Miguel Servet, 50009 Zaragoza, Spain.
authors.forename: Diana
authors.initials: D
authors.lastname: Boj-Carceller
authors.forename: Pilar
authors.initials: P
authors.lastname: Bocos-Terraz
authors.forename: Miguel
authors.initials: M
authors.lastname: Moreno-Vernis
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sanz-Paris
authors.forename: Pablo
authors.initials: P
authors.lastname: Trincado-Aznar
authors.forename: Ramón
authors.initials: R
authors.lastname: Albero-Gamboa