title: Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents.
abstract: The present Letter describes a one-pot multi-component method that allows the efficient and mild preparation of 3,5-diphenylpiperidin-2,6-dione and a new series of 3,5-diarylpiperidin-2,6-dione derivatives from ethyl 2-arylacetates, formaldehyde and ammonia/aliphatic/aromatic amines. The structures of the compounds were elucidated by IR, NMR spectroscopic data and microanalyses. The anticonvulsant activities of these compounds were evaluated by maximal electroshock seizure test and were also evaluated for motor impairment. Among the synthesized compounds, 5a, 5b, 5d, and 5e could be considered potentially the most useful and safe therapeutic compound and 5g, 5i, 5j, 5m, and 5o exhibit potent activities.
authors.affiliation: Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
authors.forename: Mariappan
authors.initials: M
authors.lastname: Babu
authors.forename: Kasi
authors.initials: K
authors.lastname: Pitchumani
authors.forename: Penugonda
authors.initials: P
authors.lastname: Ramesh
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D051379:Mice; D015394:Molecular Structure; D009069:Movement Disorders / Q000188:drug therapy; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy*; D013237:Stereoisomerism
chemical_list: D000927:Anticonvulsants; D010880:Piperidines