title: The role of miRNAs in complex formation and control.
abstract: microRibonucleic acid (miRNAs) are small regulatory molecules that act by mRNA degradation or via translational repression. Although many miRNAs are ubiquitously expressed, a small subset have differential expression patterns that may give rise to tissue-specific complexes.
  
  
  BACKGROUND
  This work studies gene targeting patterns amongst miRNAs with differential expression profiles, and links this to control and regulation of protein complexes.
  
  
  RESULTS
  We find that, when a pair of miRNAs are not expressed in the same tissues, there is a higher tendency for them to target the direct partners of the same hub proteins. At the same time, they also avoid targeting the same set of hub-spokes. Moreover, the complexes corresponding to these hub-spokes tend to be specific and nonoverlapping. This suggests that the effect of miRNAs on the formation of complexes is specific.
authors.affiliation: Department of Computing, Imperial College London, London, UK.
authors.forename: Wilson Wen Bin
authors.initials: WW
authors.lastname: Goh
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Oikawa
authors.forename: Judy Chia Ghee
authors.initials: JC
authors.lastname: Sng
authors.forename: Marek
authors.initials: M
authors.lastname: Sergot
authors.forename: Limsoon
authors.initials: L
authors.lastname: Wong
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism; D057890:Epigenomics; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: C532045:MIRN29a microRNA, human; D035683:MicroRNAs; D046912:Multiprotein Complexes; D014635:Valproic Acid