title: The effects of a multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.
abstract: Antioxidants can decrease oxidative stress and combined with acute exercise they may lead to further decreases in blood pressure. The purpose of this study was to investigate the effects of 2 weeks of antioxidant supplementation on vascular distensibility and cardiovascular hemodynamics during postexercise hypotension.
  
  
  METHODS
  Twenty young subjects were randomized to placebo (n = 10) or antioxidant supplementation (n = 10) for two weeks. Antioxidant status, vascular distensibility, and hemodynamics were obtained before, immediately, and 30 minutes after an acute bout of aerobic exercise both before and after supplementation.
  
  
  RESULTS
  Two weeks of antioxidant supplementation resulted in a greater systolic blood pressure (SBP) decrease during postexercise hypotension (PEH) and significant decreases in augmentation index versus placebo (12.5% versus 3.5%, resp.). Also ferric-reducing ability of plasma (FRAP) increased significantly (interaction P = 0.024) after supplementation.
  
  
  CONCLUSIONS
  Supplementation showed an additive effect on PEH associated with increased FRAP values and decreases in systolic blood pressure and augmentation index.
authors.affiliation: Vascular Biology and Autonomic Studies Laboratory, Appalachian State University, Boone, NC 28608, USA.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Kappus
authors.forename: Chelsea D
authors.initials: CD
authors.lastname: Curry
authors.forename: Steve
authors.initials: S
authors.lastname: McAnulty
authors.forename: Janice
authors.initials: J
authors.lastname: Welsh
authors.forename: David
authors.initials: D
authors.lastname: Morris
authors.forename: David C
authors.initials: DC
authors.lastname: Nieman
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Soukup
authors.forename: Scott R
authors.initials: SR
authors.lastname: Collier
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage* / Q000009:adverse effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D057774:Post-Exercise Hypotension / Q000097:blood / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005419:Flavonoids