title: Biomimetic coating of bisphosphonate incorporated CDHA on Ti6Al4V.
abstract: Bi-functional coatings of carbonated calcium deficient hydroxyapatite (CDHA) on Ti alloys were developed by using a biomimetic coating process. The bi-functionality was achieved by loading alendonate sodium (AS), an approved bisphosphonate drug used for the treatment of osteoporosis, into the inner layers of CDHA coatings. Three possible methods of loading AS into CDHA coatings were systematically studied and compared. The results indicated that the co-precipitation method had greater benefits and can modify the release profile of AS by incorporating AS in the inner layers of the coatings. As a preliminary study, the influences of applied AS dosage to CDHA coatings were evaluated using XRD and SEM. In vitro tests indicated that the AS content on CDHA coatings played a significant role, and optimum AS content in local area is beneficial for osteoblast cells proliferation. It is expected that the CDHA-AS coatings via the co-precipitation approach have potential for bone tissue engineering applications.
authors.affiliation: Department of Bioengineering, The University of Toledo, Toledo, OH, USA. Huan.Zhou@Rockets.utoledo.edu
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Lawrence
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Touny
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D019386:Alendronate / Q000737:chemistry; D000497:Alloys; D002118:Calcium / Q000737:chemistry*; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004164:Diphosphonates / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy*; D012964:Sodium / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D004164:Diphosphonates; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D012964:Sodium; D014025:Titanium; D002118:Calcium; D019386:Alendronate