title: [Mammary serine proteinase inhibitor subcellular expression in oral squamous cell carcinoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the subcellular expression of mammary serine proteinase inhibitor (Maspin) in oral squamous cell carcinoma and its relationship to the clinicopathological features.
  
  
  METHODS
  The Maspin protein subcellular expression was detected in 45 patients with oral squamous cell carcinoma by immunohistochemical staining. The relationship between the Maspin protein subcellular expression and the clinicopathological parameters was analyzed.
  
  
  RESULTS
  The negative rate of nuclear maspin expression was 64% (29/45), and the weakly positive rate was 11% (5/45), and the strong positive rate was 24% (11/45). Nuclear maspin expression was negatively correlated with T stage (P = 0.019), lymph node metastasis (P = 0.038) and postoperative metastasis (P = 0.004), but positively correlated with the patients' survival rate (P = 0.014). The negative rate of cytoplasmatic maspin expression was 38% (17/45), and the weakly positive rate was 31% (14/45), and the strong positive rate was 31% (14/45). Cytoplasmatic maspin expression was negatively correlated with lymph node metastasis (P = 0.038) and postoperative metastasis (P = 0.004), but positively correlated with the patients' survival rate (P = 0.014).
  
  
  CONCLUSIONS
  Maspin expression may be a significant marker in predicting prognosis of oral squamous cell carcinoma.
authors.affiliation: Department of Stomatology, Taizhou Central Hospital, Taizhou Zhejiang, China. noaste@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Hai-rong
authors.initials: HR
authors.lastname: Shu
authors.forename: Yu-kang
authors.initials: YK
authors.lastname: Ying
authors.forename: Wei-li
authors.initials: WL
authors.lastname: Wu
authors.forename: Tong
authors.initials: T
authors.lastname: Ji
authors.forename: Lai-ping
authors.initials: LP
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D015842:Serine Proteinase Inhibitors / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C085344:SERPIN-B5; D015842:Serine Proteinase Inhibitors; D015843:Serpins