title: Measles virus causes immunogenic cell death in human melanoma.
abstract: Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.
authors.affiliation: Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK.
authors.forename: O G
authors.initials: OG
authors.lastname: Donnelly
authors.forename: F
authors.initials: F
authors.lastname: Errington-Mais
authors.forename: L
authors.initials: L
authors.lastname: Steele
authors.forename: E
authors.initials: E
authors.lastname: Hadac
authors.forename: V
authors.initials: V
authors.lastname: Jennings
authors.forename: K
authors.initials: K
authors.lastname: Scott
authors.forename: H
authors.initials: H
authors.lastname: Peach
authors.forename: R M
authors.initials: RM
authors.lastname: Phillips
authors.forename: J
authors.initials: J
authors.lastname: Bond
authors.forename: H
authors.initials: H
authors.lastname: Pandha
authors.forename: K
authors.initials: K
authors.lastname: Harrington
authors.forename: R
authors.initials: R
authors.lastname: Vile
authors.forename: S
authors.initials: S
authors.lastname: Russell
authors.forename: P
authors.initials: P
authors.lastname: Selby
authors.forename: A A
authors.initials: AA
authors.lastname: Melcher
mesh_terms: D016923:Cell Death / Q000276:immunology; D045744:Cell Line, Tumor; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000378:metabolism; D008459:Measles virus / Q000276:immunology* / Q000472:pathogenicity; D008545:Melanoma / Q000276:immunology* / Q000473:pathology / Q000821:virology; D050504:Oncolytic Viruses / Q000276:immunology* / Q000472:pathogenicity; D015854:Up-Regulation
chemical_list: D024243:HMGB1 Protein; D007370:Interferon Type I