title: Cerinolactone, a hydroxy-lactone derivative from Trichoderma cerinum.
abstract: A novel metabolite, 3-hydroxy-5-(6-isopropyl-3-methylene-3,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl)dihydrofuran-2-one, trivially named cerinolactone (1), has been isolated from culture filtrates of Trichoderma cerinum together with three known butenolides containing the 3,4-dialkylfuran-2(5H)-one nucleus, harzianolide (2), T39butenolide (3), and dehydroharzianolide (4). The structure of 1 was determined by spectroscopic methods, including UV, MS, and 1D and 2D NMR analyses. In vitro tests with the purified compound exhibited activity against Pythium ultimum, Rhizoctonia solani, and Botrytis cinerea.
authors.affiliation: CNR-Istituto per la Protezione delle Piante (IPP-CNR), 80055 Portici, 80055 Naples, Italy. frvinale@unina.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Vinale
authors.forename: Isabel Arjona
authors.initials: IA
authors.lastname: Girona
authors.forename: Marco
authors.initials: M
authors.lastname: Nigro
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Mazzei
authors.forename: Alessandro
authors.initials: A
authors.lastname: Piccolo
authors.forename: Michelina
authors.initials: M
authors.lastname: Ruocco
authors.forename: Sheridan
authors.initials: S
authors.lastname: Woo
authors.forename: David Ruano
authors.initials: DR
authors.lastname: Rosa
authors.forename: Carlos López
authors.initials: CL
authors.lastname: Herrera
authors.forename: Matteo
authors.initials: M
authors.lastname: Lorito
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027421:Persea / Q000382:microbiology; D010572:Pest Control, Biological; D058968:Pythiosis / Q000188:drug therapy; D011775:Pythium / Q000187:drug effects; D012232:Rhizoctonia / Q000187:drug effects; D013030:Spain; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; C570761:cerinolactone