title: Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis.
abstract: microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. However, the mechanism of miR-195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR-195 in the cell cycle and in apoptosis.
authors.affiliation: Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: He
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Luo
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Wan
authors.forename: Deqian
authors.initials: D
authors.lastname: Jiang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics*; D004194:Disease / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data
chemical_list: C552722:MIRN195 microRNA, human; D035683:MicroRNAs