title: Clinical characteristics indicating adenomyosis at the time of hysterectomy: a retrospective study in 291 patients.
abstract: OBJECTIVE
  To better characterize adenomyosis as a disease entity.
  
  
  METHODS
  We retrospectively reviewed the medical records of women undergoing hysterectomy with a histologic diagnosis of adenomyosis, adenomyosis and leiomyomas, and leiomyomas alone.
  
  
  RESULTS
  The study included 291 women: 38 with adenomyosis alone, 56 with adenomyosis and leiomyomas, and 197 with leiomyomas alone. In univariate analysis, women with adenomyosis were younger (p = 0.018) and had lower uterine weights (p < 0.001) and more disease-specific symptoms (p = 0.008). In multinomial logistic regression analysis, a lower uterine weight (OR 0.99, CI 95% 0.99-1.0), pelvic pain (OR 4.8, CI 95% 1.5-15.2), a history of smoking (OR 2.6, CI 95% 1.1-6.5) and at least one delivery (OR 4.3, CI 95% 1.5-12.3) were associated with a greater likelihood of having adenomyosis but not leiomyomas alone.
  
  
  CONCLUSIONS
  Women undergoing hysterectomy with adenomyosis alone have different clinical characteristics from women with adenomyosis and leiomyomas and from those with only leiomyomas.
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Calwerstr. 7, 72076 Tuebingen, Germany. florin-andrei.taran@med.uni-tuebingen.de
authors.forename: F Andrei
authors.initials: FA
authors.lastname: Taran
authors.forename: Markus
authors.initials: M
authors.lastname: Wallwiener
authors.forename: Drita
authors.initials: D
authors.lastname: Kabashi
authors.forename: Ralf
authors.initials: R
authors.lastname: Rothmund
authors.forename: Katharina
authors.initials: K
authors.lastname: Rall
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kraemer
authors.forename: Sara Y
authors.initials: SY
authors.lastname: Brucker
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000706:statistics & numerical data*; D007889:Leiomyoma / Q000453:epidemiology / Q000601:surgery; D008875:Middle Aged; D009929:Organ Size; D017699:Pelvic Pain / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000601:surgery