title: Immunohistochemical expression of vascular endothelial growth factor and its correlation with tumor grade in breast ductal carcinoma.
abstract: Breast cancer is the most common cause of cancer-related death in female, after lung cancer. Angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. The role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. This study described the correlation between vascular endothelial growth factor expression and tumor grade, to define the breast cancer patients who responder to anti-vascular endothelial growth factor therapy. In this research, 200 cases of histological proved invasive ductal breast carcinomas analyzed for vascular endothelial growth factor expression by immunohistochemical staining via cross-sectional descriptive study. Vascular endothelial growth factor expressed in 72.54% of the breast cancers. The VEGF was more detectable in grade I (78.5%) than grade II (77.4%) and grade III (56.2%). There is a significant correlation between tumor grade and VEGF expression (P<0.05). According to this study, VEGF often expressed in invasive ductal breast carcinomas and inversely correlated with tumor grade. Anti-vascular endothelial growth factor postulated more convenience for tumor progression suppression in low grade tumor than high grade tumor.
authors.affiliation: Department of Pathology, Mazandaran University of Medical Sciences, Sari, Iran. a.zghasemi@yahoo.com
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Omid
authors.initials: O
authors.lastname: Emadian
authors.forename: Farshad
authors.initials: F
authors.lastname: Naghshvar
authors.forename: Ahmadreza
authors.initials: A
authors.lastname: Bekhradnia
authors.forename: Saeid
authors.initials: S
authors.lastname: Abediankenari
authors.forename: Laleh
authors.initials: L
authors.lastname: Vahedi Larijani
authors.forename: Roghaieh
authors.initials: R
authors.lastname: Moghimpour
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000502:physiology
chemical_list: D042461:Vascular Endothelial Growth Factor A