title: Regulation of self-renewal and reprogramming by TCF factors.
abstract: Wnt/β-catenin canonical pathway has very important roles both in the regulation of self-renewal and lineage differentiation of pluripotent stem cells, as well as in the reprogramming of somatic cells. In the absence of Wnt stimulation, the target genes of the pathway are repressed or down-regulated. Conversely, when β-catenin is stabilized there is an accumulation of cytoplasmic and nuclear β-catenin that allows up-regulation of its target genes. However, the molecular mechanisms downstream of β-catenin that regulate self-renewal of embryonic stem cells remain unclear. It has been proposed that β-catenin acts through members of the T-cell factor (TCF) family. Recent studies have confirmed the role of Tcf3 (Tcf7l1) as a transcriptional repressor in embryonic stem cells, and they have also proposed a new mechanistic view as to how activation of the Wnt/β-catenin pathway can overcome this repression.
authors.affiliation: Centre for Genomic Regulation and Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ombrato
authors.forename: Frederic
authors.initials: F
authors.lastname: Lluis
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Cosma
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000378:metabolism; D006801:Humans; D051822:T Cell Transcription Factor 1 / Q000378:metabolism; D051820:TCF Transcription Factors / Q000378:metabolism*; D058125:Transcription Factor 7-Like 1 Protein / Q000378:metabolism; D015854:Up-Regulation; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051822:T Cell Transcription Factor 1; D051820:TCF Transcription Factors; D058125:Transcription Factor 7-Like 1 Protein; D051153:Wnt Proteins; D051176:beta Catenin; C407909:TCF3 protein, human; C497576:TCF7 protein, human; C544912:TCF7L1 protein, human