title: Mixture theory-based poroelasticity as a model of interstitial tissue growth.
abstract: This contribution presents an alternative approach to mixture theory-based poroelasticity by transferring some poroelastic concepts developed by Maurice Biot to mixture theory. These concepts are a larger RVE and the subRVE-RVE velocity average tensor, which Biot called the micro-macro velocity average tensor. This velocity average tensor is assumed here to depend upon the pore structure fabric. The formulation of mixture theory presented is directed toward the modeling of interstitial growth, that is to say changing mass and changing density of an organism. Traditional mixture theory considers constituents to be open systems, but the entire mixture is a closed system. In this development the mixture is also considered to be an open system as an alternative method of modeling growth. Growth is slow and accelerations are neglected in the applications. The velocity of a solid constituent is employed as the main reference velocity in preference to the mean velocity concept from the original formulation of mixture theory. The standard development of statements of the conservation principles and entropy inequality employed in mixture theory are modified to account for these kinematic changes and to allow for supplies of mass, momentum and energy to each constituent and to the mixture as a whole. The objective is to establish a basis for the development of constitutive equations for growth of tissues.
authors.affiliation: The New York Center for Biomedical Engineering and The Department of Biomedical Engineering, Grove School of Engineering of The City College and The Graduate School of The City University of New York, New York, NY 10031, U. S. A.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Cowin
authors.forename: Luis
authors.initials: L
authors.lastname: Cardoso