title: [Role of repair gene polymorphism in estimating the sensitivity of human genome to radon in concentrations exceeding maximum permissible level].
abstract: The paper gives the results of investigating chromosome aberrations in human peripheral blood lymphocytes due to DNA repair genes, such as hOGG1, ADPRT, APE1, XRCC1, XpG, XpC, XpD, and NBS1, upon long-term exposure to excess indoor radon concentrations. The frequency of chromosome aberrations was found to be significantly lower in the carriers of the genotype hOGG1 326 Ser/Ser (versus the variant Ser/Cys), APE1 148 Asp/Asp (versus Val/Ala and Ala/Ala). The study polymorphic systems were shown to be of value in giving rise to individual types of chromosome aberrations (single fragments and chromosome exchanges).
authors.forename: V G
authors.initials: VG
authors.lastname: Druzhinin
authors.forename: A N
authors.initials: AN
authors.lastname: Volkov
authors.forename: A N
authors.initials: AN
authors.lastname: Glushkov
authors.forename: T A
authors.initials: TA
authors.lastname: Golovina
authors.forename: V I
authors.initials: VI
authors.lastname: Minina
authors.forename: F I
authors.initials: FI
authors.lastname: Ingel'
authors.forename: A V
authors.initials: AV
authors.lastname: Larionov
authors.forename: A V
authors.initials: AV
authors.lastname: Meĭer
authors.forename: A A
authors.initials: AA
authors.lastname: Lunina
authors.forename: T A
authors.initials: TA
authors.lastname: Tolochko
authors.forename: L V
authors.initials: LV
authors.lastname: Akhal'tseva
authors.forename: E K
authors.initials: EK
authors.lastname: Krivtsova
authors.forename: N A
authors.initials: NA
authors.lastname: Iurtseva
authors.forename: V V
authors.initials: VV
authors.lastname: Iurchenko
mesh_terms: D000293:Adolescent; D000396:Air Pollutants, Radioactive / Q000032:analysis; D016902:Air Pollution, Indoor / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002869:Chromosome Aberrations / Q000528:radiation effects*; D015331:Cohort Studies; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D015894:Genome, Human / Q000528:radiation effects*; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D020714:Maximum Tolerated Dose; D020641:Polymorphism, Single Nucleotide; D011886:Radon / Q000032:analysis; D012621:Seasons; D012800:Siberia
chemical_list: D000396:Air Pollutants, Radioactive; D011886:Radon