title: Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors.
abstract: The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Winkler
authors.forename: André K
authors.initials: AK
authors.lastname: Isaacs
authors.forename: Chaomei
authors.initials: C
authors.lastname: Xiang
authors.forename: Valérie
authors.initials: V
authors.lastname: Baubet
authors.forename: Nadia
authors.initials: N
authors.lastname: Dahmane