title: 1-Alkyl-5-((di)alkylamino) tetrazoles: building blocks for peptide surrogates.
abstract: An approach to the synthesis of 1-alkyl-5-((di)alkylamino)tetrazoles by nucleophilic substitution in 1-alkyl-5-sulfonyltetrazoles with anions generated from the primary or secondary amines was developed. Tolerance of the method to the presence of some functional groups (i.e., protected amine) in both components of the reaction was demonstrated. Obtained tetrazoles are promising building blocks for the design of peptide surrogates, in particular, for replacement approaches of alkyl urea derivatives.
authors.affiliation: Kyiv National Taras Shevchenko University, Volodymyrska Street 64, Kyiv 01601, Ukraine.
authors.forename: Andriy V
authors.initials: AV
authors.lastname: Tymtsunik
authors.forename: Vitaliy A
authors.initials: VA
authors.lastname: Bilenko
authors.forename: Serhiy O
authors.initials: SO
authors.lastname: Kokhan
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Grygorenko
authors.forename: Dmitriy M
authors.initials: DM
authors.lastname: Volochnyuk
authors.forename: Igor V
authors.initials: IV
authors.lastname: Komarov
mesh_terms: D000588:Amines / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D000588:Amines; D010455:Peptides; D013441:Sulfinic Acids; D013777:Tetrazoles; D014508:Urea