title: Mechanisms of tissue injury in lupus nephritis.
abstract: Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
authors.affiliation: Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 912 MSC 637 Charleston, SC 29425-6370, USA.
authors.forename: Tamara K
authors.initials: TK
authors.lastname: Nowling
authors.forename: Gary S
authors.initials: GS
authors.lastname: Gilkeson
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008181:Lupus Nephritis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D051379:Mice
chemical_list: D001323:Autoantibodies; D016207:Cytokines