title: Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice.
abstract: Human PSGL-1 is a receptor for EV71 that facilitates EV71 entry and replication in mouse cells. We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line. Expression of human PSGL-1 failed to enhance infectivity of clinical EV71 strains in mice; however, it promoted replication and symptom severity at an earlier stage in mice upon infection with a mouse-adapted EV71 strain. We therefore conclude that human PSGL-1 alone is not sufficient to modulate infection with the clinical EV71 strains of genotype C4 in mice.
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, China.
authors.forename: Jiangning
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Xiongzhi
authors.initials: X
authors.lastname: Quan
authors.forename: Chunmei
authors.initials: C
authors.lastname: Ma
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
authors.forename: Lianfeng
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D029821:Enterovirus A, Human / Q000472:pathogenicity*; D004769:Enterovirus Infections / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein; D011991:Receptors, Virus