title: Prognostic factors for patients with solitary bone metastasis.
abstract: BACKGROUND
  The term 'solitary bone metastasis' is defined in the present study as a single bone metastasis originating from a primary cancer without visceral organ metastasis. We assessed the survival rates and prognostic factors in 42 patients with solitary bone metastasis, and discussed the impact of different surgical strategies on survival.
  
  
  METHODS
  We retrospectively analyzed data from 42 patients (25 male, 17 female) who underwent treatment for solitary bone metastasis at a single institution. The median age of the patients was 64.5 years (range 41-82 years). The patients were followed for an average period of 21.2 months (range 0.4-127.3 months). Their clinical records were retrospectively reviewed. Factors influencing survival were determined using univariate and multivariate analyses; particular attention was paid to the orthopedic surgery used for solitary bone metastasis.
  
  
  RESULTS
  The 1-year survival rate was 76.5%, and the median survival period was 30.0 months. The presence of primary cancer and poor performance status were identified as independent prognostic factors using Cox regression multivariate analysis. Tumor resection and surgical margin were not significantly related to patient survival.
  
  
  CONCLUSIONS
  The results of this analysis indicated that the prognosis for patients with solitary bone metastasis depended on the presence of primary cancer and on poor performance status.
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. hoshi@med.osaka-cu.ac.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Hoshi
authors.forename: Jun
authors.initials: J
authors.lastname: Takada
authors.forename: Makoto
authors.initials: M
authors.lastname: Ieguchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome