title: Three-component reactions of isocyanides, dialkyl acetylenedicarboxylates, and trans-cinnamoyl chlorides for the synthesis of highly functionalized 2-vinyl furans.
abstract: In this study, we present a convenient and efficient method for the synthesis of novel, highly substituted 2-vinyl furans using a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reacted with trans-cinnamoyl chlorides to produce the desired products in good yields.
authors.affiliation: Chemistry Department, University of Birjand, Birjand, Iran. aa_esmaeili@yahoo.com
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Esmaeili
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Zangouei
authors.forename: Rahele
authors.initials: R
authors.lastname: Hosseinabadi
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Fakhari
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000138:chemical synthesis* / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D012997:Solvents / Q000737:chemistry
chemical_list: D000480:Alkynes; D001565:Benzoates; D002934:Cinnamates; D003486:Cyanides; D005231:Fatty Acids, Unsaturated; D005663:Furans; D012997:Solvents; C037551:cinnamoyl chloride; C024060:2-butynedioic acid; C027684:2-vinylfuran; C013409:benzoyl chloride