title: Enteric viral pathogens in children with inflammatory bowel disease.
abstract: The causes of exacerbations of inflammatory bowel disease (IBD) are unknown. The presence of RNA of an enterovirus, norovirus GI, norovirus GII, rotavirus, astrovirus, and sapovirus was sought in stool samples of 50 children (median age 12.9 years) undergoing gastrointestinal endoscopies for IBD or its exclusion (Crohn's disease n = 18, ulcerative colitis n = 13, indeterminate colitis n = 2, non-IBD n = 17). Viral RNA was found in three fecal samples (norovirus GII n = 2, sapovirus n = 1), all in children without IBD. Therefore, enteral viruses may play only a minor role in IBD.
authors.affiliation: Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. kaija-leena.kolho@helsinki.fi
authors.forename: Kaija-Leena
authors.initials: KL
authors.lastname: Kolho
authors.forename: Päivi
authors.initials: P
authors.lastname: Klemola
authors.forename: Marja-Leena
authors.initials: ML
authors.lastname: Simonen-Tikka
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Ollonen
authors.forename: Merja
authors.initials: M
authors.lastname: Roivainen
mesh_terms: D000293:Adolescent; D019200:Astroviridae / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology* / Q000821:virology*; D003424:Crohn Disease / Q000453:epidemiology / Q000821:virology*; D004770:Enterovirus / Q000235:genetics; D005243:Feces / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D029322:Norovirus / Q000235:genetics; D012367:RNA, Viral / Q000302:isolation & purification*; D012401:Rotavirus / Q000235:genetics; D029341:Sapovirus / Q000235:genetics
chemical_list: D012367:RNA, Viral