title: Factors influencing posttransplantation employment: does depression have an impact?
abstract: BACKGROUND
  Depressive disorders are the leading cause of disability in the United States. Liver transplant recipients often have significant psychiatric morbidity, including depression. One of the potential consequences of depression is the inability to work.
  
  
  OBJECTIVE
  The objective of this study was to determine if there is any relationship between depression and posttransplantation employment status in liver transplant recipients.
  
  
  METHODS
  Patients, 18 years of age or older, who had received liver transplants from January 2007 to July 2009 were identified for the retrospective analysis. Individual posttransplantation patient charts were reviewed for patient demographics, transplantation indication, employment history, depression diagnosis, and medications. The pretransplantation charts were used to obtain family psychiatric history, patient psychiatric history, past drug, alcohol, and tobacco use, and pretransplantation employment status.
  
  
  RESULTS
  A total of 91 patients were evaluated, of which 59.3% were males and 40.7% were females, with a mean age of 56 years. In our sample, 23% and 29% of patients were depressed pretransplantation and posttransplantation, respectively. The number of unemployed patients also increased from 10.9%-23.1%. A logistic regression was performed to identify the factors influencing employment posttransplantation, which indicated pretransplantation employment, gender (males more likely to return to work), and depression post transplantation as significant factors with odds rations of 128, 4.1, and 11.5 and corresponding P values of <.0001, .04 and .008, respectively.
  
  
  CONCLUSIONS
  Posttransplantation depression is significantly associated with post-liver transplantation unemployment. Improved management of depression may facilitate a patient's return to work after transplantation.
authors.affiliation: James L Winkle College of Pharmacy, University of Cincinnati, Department of Pharmacy, University Hospital, Cincinnati, Ohio 45267-0004, USA. Elizabeth.Gorevski@uc.edu
authors.forename: E
authors.initials: E
authors.lastname: Gorevski
authors.forename: P
authors.initials: P
authors.lastname: Succop
authors.forename: J
authors.initials: J
authors.lastname: Sachdeva
authors.forename: R
authors.initials: R
authors.lastname: Scott
authors.forename: J
authors.initials: J
authors.lastname: Benjey
authors.forename: G
authors.initials: G
authors.lastname: Varughese
authors.forename: J
authors.initials: J
authors.lastname: Martin-Boone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D017281:Cost of Illness; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000523:psychology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009820:Ohio; D012179:Retirement / Q000523:psychology*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014478:Unemployment / Q000523:psychology*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents