title: Association between XPD Lys751Gln  polymorphism and risk of head and neck  cancer: a meta-analysis.
abstract: Several  studies have investigated the association between Lys751Gln polymorphism in the  xeroderma pigmentosum group D (XPD) gene and risk of head and neck  cancer; however, the published results are conflicting. We conducted a  meta-analysis that comprised 15 published case-control studies examining the  association of head and neck cancer risk with XPD Lys751Gln polymorphism  in different populations, based on the data identified in Medline up to  November 2010. Odds ratios (ORs) with 95% confidence intervals (CI) were used  to assess the strength of the association. Overall, significantly elevated head  and neck cancer risk was associated with XPD Lys751Gln polymorphism when  all studies were pooled into the meta-analysis [(Gln/Gln + Lys/Gln) vs Lys/Lys: OR = 1.12, 95%CI = 1.03-1.22, P < 0.01, heterogeneity P =  0.11]. In the subgroup analysis by ethnicity, borderline significantly  increased risk was found for Europeans [(Gln/Gln + Lys/Gln) vs Lys/Lys:  OR = 1.11, 95%CI = 1.00-1.23, P < 0.05]. In conclusion, our meta-analysis  demonstrated that XPD Lys751Gln polymorphism could be a prediction  marker for risk of head and neck cancer.
authors.affiliation: Institute of Dental Research, Nanjing Medical University, Nanjing, PR China.
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.forename: Y M
authors.initials: YM
authors.lastname: Niu
authors.forename: R X
authors.initials: RX
authors.lastname: Wang
authors.forename: H Z
authors.initials: HZ
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Chen
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human