title: Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation.
abstract: Cutaneous scarring is often the epicenter of patient-related concerns, and the question "Will there be a scar?" is one that is all too familiar to the everyday clinician. In approaching this topic, we have reviewed the pathology, the embryology, and the molecular biology of cutaneous scarring.
authors.affiliation: Department of Plastic and Burns, Chelsea and Westminster Hospital, London, United Kingdom.
authors.forename: Christos
authors.initials: C
authors.lastname: Profyris
authors.forename: Christos
authors.initials: C
authors.lastname: Tziotzios
authors.forename: Isabel
authors.initials: I
authors.lastname: Do Vale
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D051766:Early Growth Response Protein 1 / Q000502:physiology; D006097:Granulation Tissue / Q000502:physiology / Q000503:physiopathology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D015398:Signal Transduction; D012867:Skin / Q000473:pathology / Q000503:physiopathology*; D015291:Transforming Growth Factors / Q000502:physiology; D060449:Wnt Signaling Pathway; D014945:Wound Healing / Q000502:physiology*
chemical_list: D051766:Early Growth Response Protein 1; C484414:HOXB13 protein, human; D018398:Homeodomain Proteins; D018836:Inflammation Mediators; D010982:Platelet-Derived Growth Factor; D015291:Transforming Growth Factors