title: The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma.
abstract: OBJECTIVE
  We performed an age-matched case-control study to compare the clinical and pathology outcomes between histologically diagnosed primary malignant mixed műllerian tumour (MMMT) of the uterus and endometrial carcinoma.
  
  
  METHODS
  Thirty-two women were treated for primary MMMT at seven tertiary medical centres in Korea from 2000 to 2006. For each woman with MMMT, four women with endometrioid and two with non-endometrioid endometrial carcinoma were selected as age-matched controls for analysis. Medical records were retrospectively reviewed to obtain outcome data.
  
  
  RESULTS
  The incidence of MMMT was 2.57% (32/1244). In comparison with women with endometrioid endometrial cancer, those with MMMT were characterised by large tumour size, higher incidence of adnexal involvement and lymph node metastases, leading to advanced disease stage. Despite the frequent use of adjuvant treatment, the 5-year survival rate of women with MMMT was significantly poorer than those with endometrioid endometrial cancer. However, women with MMMT were not significantly different from those with non-endometrioid endometrial cancer in terms of important pathologic variables, apart from larger tumour size. In addition, the 5-year survival rate of women MMMT was poorer than that those with non-endometrioid endometrial cancer, but the difference was not statistically significant.
  
  
  CONCLUSIONS
  Malignant mixed műllerian tumour is characterised by a high incidence of lymph node metastases and advanced stage at diagnosis, leading to poorer overall survival than other subtypes of endometrial carcinoma. Clinical trials for MMMT are critical for improving treatment strategies.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Korea.
authors.forename: Seo-Yun
authors.initials: SY
authors.lastname: Tong
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Choi
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Jao Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Chi-Heum
authors.initials: CH
authors.lastname: Cho
authors.forename: Seok-Mo
authors.initials: SM
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
authors.forename: Chan-Yong
authors.initials: CY
authors.lastname: Park
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Kim
mesh_terms: D000368:Aged; D018269:Carcinoma, Endometrioid / Q000401:mortality / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology*