title: [Comparative analysis between breath test, serological immunoassay and rapid-urease test for detection of Helicobacter pylori infection in Mexican patients with non-investigated dyspepsia].
abstract: BACKGROUND
  There are multiple Helicobacter pylori (Hp) detection tests, some are invasive and other noninvasive. The diagnostic accuracy of these methods varies according to the prevalence of the disease.
  
  
  OBJECTIVE
  To determine the diagnostic accuracy of the breath test, serology and rapid urease test, considering gastric biopsy with Giemsa stain as the gold standard in Hp-infected subjects with uninvestigated dyspepsia.
  
  
  METHODS
  Eighty four subjects (64 women, mean age 45 years) who were referred for dyspeptic symptoms were evaluated. Also, 20 healthy volunteers (12 men, average age 38 years) were evaluated. All the subjects underwent hystological analysis with Giemsa stain, breath test (Heliprobe®), rapid urease test (CLOtest®) and serological immunoassay (Hexagon®).
  
  
  RESULTS
  Overall, Hp infection was diagnosed by histological analysis in 59 subjects (49 patients and 10 healthy subjects). Positivity to breath test, rapid urease test and serology were 56%, 46% and 44% respectively. Agreement with the histological analysis was 0.902 for the breath test, 0.620 for rapid urease test and 0.45 for serology. The area under the curve for the breath test was 0.95, for the rapid urease test was 0.82 and for serological test was 0.74.
  
  
  CONCLUSIONS
  In our population, the breath test shown to have a diagnostic accuracy equivalent to histological analysis by Giemsa in subjects with uninvestigated dyspepsia.
authors.affiliation: Laboratorio de Fisiología Digestiva y Motilidad Gastrointestinal. Instituto de Investigaciones Medico-Biológicas, Universidad Veracruzana, Veracruz.
authors.forename: G
authors.initials: G
authors.lastname: Alarcón-Rivera
authors.forename: G
authors.initials: G
authors.lastname: Vázquez-Jiménez
authors.forename: E
authors.initials: E
authors.lastname: de la Cruz-Patiño
authors.forename: M
authors.initials: M
authors.lastname: Abarca
authors.forename: E
authors.initials: E
authors.lastname: Leyva
authors.forename: F
authors.initials: F
authors.lastname: Delgado
authors.forename: I
authors.initials: I
authors.lastname: Ruíz-Juárez
authors.forename: P
authors.initials: P
authors.lastname: Grube-Pagola
authors.forename: F
authors.initials: F
authors.lastname: Roesch-Dietlen
authors.forename: J M
authors.initials: JM
authors.lastname: Remes-Troche
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001944:Breath Tests; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000209:etiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D014510:Urease; D055815:Young Adult
chemical_list: D014510:Urease