title: Common European mitochondrial haplogroups in the risk for psoriasis and psoriatic arthritis.
abstract: Mitochondrial dysfunction could contribute to the pathogenesis of psoriasis (Ps) and Ps-arthritis (PsA). Several common mtDNA polymorphisms/haplogroups have been linked to differences in the production of reactive oxygen species and mitochondrial oxidative damage. To test the hypothesis of an association between mtDNA variants and Ps/PsA, we studied the single-nucleotide polymorphisms that define the common European haplogroups in a total of 325 patients and 300 controls from Spain. No allele/haplogroup was significantly associated with the risk for Ps. However, haplogroup J was significantly less frequent among patients with PsA, suggesting a protective effect in our population (p=0.04; odds ratio=0.39). We concluded that mtDNA may have a role in Ps and PsA.
authors.affiliation: Dermatología II, Hospital Universitario Central Asturias (HUCA), Oviedo, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Coto-Segura
authors.forename: Jorge
authors.initials: J
authors.lastname: Santos-Juanes
authors.forename: Juan
authors.initials: J
authors.lastname: Gómez
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Belén
authors.initials: B
authors.lastname: Alonso
authors.forename: Ana I
authors.initials: AI
authors.lastname: Corao
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D012306:Risk; D013030:Spain; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial