title: Meta-analysis demonstrates no association between p53  codon 72 polymorphism and prostate cancer risk.
abstract: We examined whether p53 codon 72 polymorphism confers  prostate cancer risk by conducting a meta-analysis. Two investigators  independently searched the Pubmed, Embase and CBM databases. This meta-analysis  was made of seven case-control studies, that included 892 prostate cancer cases  and 1020 healthy controls. Meta-analysis results based on all the studies  showed no significant association between p53 codon 72 polymorphism and  prostate cancer risk in the comparisons of Pro allele vs Arg allele;  Pro/Pro + Pro/Arg vs Arg/Arg; Pro/Pro vs Pro/Arg + Arg/Arg;  Pro/Pro vs Arg/Arg, and Pro/Arg vs Arg/Arg [odds ratio (OR) =  1.09, 95% confidence interval (CI) = 0.87-1.36, P = 0.47; OR = 1.22, 95%CI =  0.86-1.73, P = 0.27; OR = 1.03, 95%CI = 0.62-1.72, P = 0.91; OR = 1.22, 95%CI =  0.66-2.26, P = 0.52; OR = 1.25, 95%CI = 0.84-1.87, P = 0.27, respectively]. In the  subgroup analysis by ethnicity, no association was found between p53 codon 72  polymorphism and prostate cancer risk both in Caucasian and Asian populations.  We found no association between p53 codon 72 polymorphism and prostate cancer  risk.
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: M S
authors.initials: MS
authors.lastname: Li
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Teng
mesh_terms: D000483:Alleles; D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D044466:Asian People; D016022:Case-Control Studies; D003062:Codon / Q000737:chemistry / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011467:Prostate; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D044465:White People
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53