title: Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.
abstract: OBJECTIVE
  To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention.
  
  
  METHODS
  
  
  
  METHODS
  Longitudinal, clinical intervention study with an increase in physical activity, and nutritional recommendations based on the 'Optimized Mixed Diet for German Children and Adolescents' (Research Institute of Child Nutrition, Germany).
  
  
  METHODS
  75 overweight children (40 male, mean BMI 30.4±5.5 kg/m², mean age 12.6±2.6 years).
  
  
  METHODS
  Genotyping by means of a TaqMan SNP genotyping assay. Lean and fat mass were determined by means of DXA.
  
  
  RESULTS
  For the whole study population, the 6-month lifestyle intervention resulted in a significant improvement (before intervention minus time point 6 months; mean±SD) in BMI-SDS (0.10±0.17, p<0.001), HOMA (1.41±3.19, p<0.001) and relative fat-mass-SDS (0.09±0.23, p=0.005). Before and after lifestyle intervention, there was no significant difference between heterozygote (n=52) and homozygote (n=21) carriers of the FTO gene in terms of BMI, body composition, and the metabolic profile (Insulin, HOMA, lipids, liver function tests).
  
  
  CONCLUSIONS
  Variants in the FTO gene are common in obese children but have no impact on body composition and metabolism before and after lifestyle intervention.
authors.affiliation: Pediatric Endocrinology and Diabetes, University Children's Hospital, Tuebingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Schum
authors.forename: G
authors.initials: G
authors.lastname: Blumenstock
authors.forename: K
authors.initials: K
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Schweizer
authors.forename: C
authors.initials: C
authors.lastname: Pfaff
authors.forename: N
authors.initials: N
authors.lastname: Schurr
authors.forename: M B
authors.initials: MB
authors.lastname: Ranke
authors.forename: G
authors.initials: G
authors.lastname: Binder
authors.forename: S
authors.initials: S
authors.lastname: Ehehalt
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001823:Body Composition / Q000235:genetics*; D002648:Child; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008660:Metabolism / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D011506:Proteins / Q000235:genetics*; D040242:Risk Reduction Behavior; D013997:Time Factors
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human