title: High calorie diet augments age-associated sleep impairment in Drosophila.
abstract: The fruit fly, Drosophila melanogaster is an established model used for aging and longevity studies and more recently for sleep studies. Mammals and Drosophila share various physiological, pathological, pharmacological and genetic similarities in these processes. In particular, sleep is essential for survival in both species and both have age-associated sleep quality alterations. Here we report that a high calorie diet, which accelerates the aging process and reduces lifespan across species, also accelerates age-associated sleep changes in Drosophila. These changes are more evident in the dopamine transporter mutant, fumin, that displays a short sleep phenotype due to enhanced dopaminergic signaling. With normal food, fumin mutants sleep for only one third of the time that the control flies do, but still show equivalent longevity. However, when on a mildly high calorie diet, their sleep length shows a marked decrease and they have a reduced longevity. These data indicate that the age-associated change in sleep in Drosophila is a physiologically regulated aging process that is tightly linked to calorie intake and that the dopamine level plays an important role. In addition, this provides another evidence that sleep is essential for the longevity of Drosophila.
authors.affiliation: Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Jun
authors.initials: J
authors.lastname: Tomita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takahama
authors.forename: Taro
authors.initials: T
authors.lastname: Ueno
authors.forename: Madoka
authors.initials: M
authors.lastname: Mitsuyoshi
authors.forename: Erina
authors.initials: E
authors.lastname: Sakamoto
authors.forename: Shoen
authors.initials: S
authors.lastname: Kume
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kume
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D008136:Longevity / Q000235:genetics / Q000502:physiology; D012890:Sleep / Q000235:genetics / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*
chemical_list: C493211:DAT protein, Drosophila; D050483:Dopamine Plasma Membrane Transport Proteins; D029721:Drosophila Proteins