title: Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri.
abstract: Trigocherrin A, a chlorinated and highly oxygenated daphnane diterpenoid orthoester (DDO), was isolated from the bark of Trigonostemon cherrieri. Trigocherrin A is the first example of a naturally occurring halogenated DDO. Its structure was elucidated by comprehensive analysis of NMR spectroscopic data, and its absolute configuration was determined by comparison of experimental and theoretically calculated ECD spectra. Trigocherrin A exhibited a potent and selective effect against Chikungunya virus in Vero cells.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Allard
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Marie-Elise Tran Huu
authors.initials: ME
authors.lastname: Dau
authors.forename: Pieter
authors.initials: P
authors.lastname: Leyssen
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002646:Chikungunya virus / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D004224:Diterpenes; C571266:trigocherrin A