title: Localized in vivo hyperpolarization transfer sequences.
abstract: In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13)C(2)] and sodium [1-(13)C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T(1) (13)C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of (13)C-acetate metabolism.
authors.affiliation: Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. mor.mishkovsky@epfl.ch
authors.forename: Mor
authors.initials: M
authors.lastname: Mishkovsky
authors.forename: Tian
authors.initials: T
authors.lastname: Cheng
authors.forename: Arnaud
authors.initials: A
authors.lastname: Comment
authors.forename: Rolf
authors.initials: R
authors.lastname: Gruetter
mesh_terms: D000085:Acetates / Q000032:analysis*; D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014018:Tissue Distribution
chemical_list: D000085:Acetates