title: Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer.
abstract: Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection.
authors.affiliation: National Engineering Center for Biochip at Shanghai, Shanghai, PR China.
authors.forename: Hanshao
authors.initials: H
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Bingya
authors.initials: B
authors.lastname: Liu
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Xianxin
authors.initials: X
authors.lastname: Meng
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yueyun
authors.initials: Y
authors.lastname: Ma
authors.forename: Huasheng
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C526012:MIRN378 microRNA, human; D035683:MicroRNAs