title: A fatal case of severe methaemoglobinemia due to nitrobenzene poisoning.
abstract: An acute poisoning with nitrobenzene presenting as methaemoglobinemia is an uncommon medical emergency. A young girl with nitrobenzene induced methaemoglobinaemia died despite use of mechanical ventilator, administration of oral methylene blue and parenteral ascorbic acid. Here author highlights the rare occurrence of such cases, methaemoglobin induced severe oxidative stress, unexplained splenomegaly and leucocytosis and the ineffectivity of oral methylene blue and other supportive measures in evading death due to nitrobenzene poisoning.
authors.affiliation: Department of Internal Medicine, CSM Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Gupta
authors.forename: Nirdesh
authors.initials: N
authors.lastname: Jain
authors.forename: Avinash
authors.initials: A
authors.lastname: Agrawal
authors.forename: Arjun
authors.initials: A
authors.lastname: Khanna
authors.forename: Manish
authors.initials: M
authors.lastname: Gutch
mesh_terms: D000293:Adolescent; D000931:Antidotes / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced*; D008751:Methylene Blue / Q000008:administration & dosage; D009578:Nitrobenzenes / Q000506:poisoning*; D013405:Suicide
chemical_list: D000931:Antidotes; D009578:Nitrobenzenes; D001205:Ascorbic Acid; D008751:Methylene Blue