title: Simultaneous resection of metastatic melanoma in the esophagus and primary cutaneous melanoma showing partial regression: report of a case.
abstract: We herein describe a case of melanoma that metastasized to the esophagus from a primary melanoma of the abdominal skin in a 40-year-old female. Esophagography and endoscopy demonstrated a 30-mm protruding mass in the proximal third of the esophagus, and this was diagnosed as malignant melanoma by mucosal biopsy. The patient also had a pigmented lesion on her abdominal skin, which was diagnosed immunohistochemically as a primary malignant melanoma from the resected specimen. The esophageal tumor was resected by transthoracic esophagectomy. Histopathologically, the radial growth phase of the tumor cells was not present in the esophageal lesion, which was diagnosed as melanoma metastatic to the esophagus. Postoperatively, the patient received 5 courses of DAV-Feron chemotherapy. Eight months after the chemotherapy, multiple metastases developed, including to the subcutis, bronchus, liver, adrenal gland and mediastinum. Chemotherapy was not effective at this stage. The patient died of multiple organ failure 21 months after initial esophagectomy.
authors.affiliation: Department of Surgery, Ohta Nishinouchi Hospital, Nishinouchi 2-5-20, Kohriyama, Fukushima, 963-8558, Japan. kuma7@ohta-hp.or.jp
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Keiko
authors.initials: K
authors.lastname: Miura
authors.forename: Tohru
authors.initials: T
authors.lastname: Nishida
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Igari
authors.forename: Takanori
authors.initials: T
authors.lastname: Ochiai
authors.forename: Michio
authors.initials: M
authors.lastname: Iida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Hajime
authors.initials: H
authors.lastname: Odajima
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Kawano
authors.forename: Kaiyo
authors.initials: K
authors.lastname: Takubo
mesh_terms: D000328:Adult; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D009365:Neoplasm Regression, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*