title: Application of vitamin D and derivatives in hematological malignancies.
abstract: The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far, in vitro and in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review.
authors.affiliation: Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, TX 79430, USA.
authors.forename: Minji
authors.initials: M
authors.lastname: Kim
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mirandola
authors.forename: Apurva
authors.initials: A
authors.lastname: Pandey
authors.forename: Diane D
authors.initials: DD
authors.lastname: Nguyen
authors.forename: Marjorie R
authors.initials: MR
authors.lastname: Jenkins
authors.forename: Meryem
authors.initials: M
authors.lastname: Turcel
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D002986:Clinical Trials as Topic; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects; D014807:Vitamin D / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014807:Vitamin D