title: Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells.
abstract: This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines: nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death.
authors.affiliation: Department of Biology, University of Copenhagen, Copenhagen, Denmark. ekhoffmann@bio.ku.dk
authors.forename: Else Kay
authors.initials: EK
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D017209:Apoptosis; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D048429:Cell Size; D018118:Chloride Channels / Q000378:metabolism / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology; D024683:Potassium Channels, Tandem Pore Domain / Q000378:metabolism / Q000502:physiology
chemical_list: D018118:Chloride Channels; D007473:Ion Channels; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain