title: Increased prevalence of colorectal neoplasia in korean patients with sporadic duodenal adenomas: a case-control study.
abstract: OBJECTIVE
  Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects.
  
  
  METHODS
  This retrospective case-control study used the databases of 3 teaching hospitals in Gyeonggi-do Province, South Korea. The colonoscopy findings of patients with sporadic duodenal adenomas were compared with those of age- and gender-matched healthy individuals who had undergone gastroduodenoscopies and colonoscopies during general screening examinations.
  
  
  RESULTS
  Between 2001 and 2008, 45 patients were diagnosed endoscopically with sporadic duodenal adenomas; 26 (58%) of these patients received colonoscopies. Colorectal neoplasia (42% vs 21%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.1 to 7.4) and advanced colorectal adenoma (19% vs 3%; OR, 9.0; 95% CI, 1.6 to 50.0) were significantly more common in patients with sporadic duodenal adenomas than in healthy control subjects.
  
  
  CONCLUSIONS
  Compared with healthy individuals, patients with sporadic duodenal adenomas were at a significantly higher risk for developing colorectal neoplasia. Such at-risk patients should undergo routine screening colonoscopies.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Woo Chul
authors.initials: WC
authors.lastname: Chung
authors.forename: Bo-In
authors.initials: BI
authors.lastname: Lee
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Roh
authors.forename: Jae Wuk
authors.initials: JW
authors.lastname: Kwak
authors.forename: Sun-Mee
authors.initials: SM
authors.lastname: Hwang
authors.forename: Yoon Ho
authors.initials: YH
authors.lastname: Ko
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Oh
authors.forename: Hyunjung
authors.initials: H
authors.lastname: Cho
authors.forename: Hiun-Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Cho