title: [Management of colorectal liver metastases after induction treatment. The pathologist's role in 2011].
abstract: The management of colorectal liver metastases has been improved these last years. The efficacy of chemotherapy regimens and targeted therapies has led to a better prognosis. It has also allowed the resection of metastases initially unresectable. In this setting, the pathologist plays a major role. He is involved in the gross examination, in order to perform an adequate sampling of the lesions. He is also involved at the morphological level, for the assessment of the pathological response, which is now recognized as a prognostic factor and a marker of sensitivity or resistance to a given treatment. Moreover, the determination of predictive markers of response or resistance to induction treatments will constitute a supplementary and major challenge for the pathologist.
authors.affiliation: Service de pathologie, CRLC C Val d'Aurelle, Montpellier cedex, France. fbibeau@valdorel.fnclcc.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bibeau
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rivière
authors.forename: Florence
authors.initials: F
authors.lastname: Boissière
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Jourdan
authors.forename: Xavier
authors.initials: X
authors.lastname: Bodin
authors.forename: Véronique
authors.initials: V
authors.lastname: Perrault
authors.forename: Céline
authors.initials: C
authors.lastname: Cantos
authors.forename: Rosy
authors.initials: R
authors.lastname: Lavaill
authors.forename: Marc
authors.initials: M
authors.lastname: Ychou
authors.forename: François
authors.initials: F
authors.lastname: Quenet
authors.forename: Benoit
authors.initials: B
authors.lastname: Terris
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D060828:Induction Chemotherapy; D033183:Interdisciplinary Communication; D008113:Liver Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D058990:Molecular Targeted Therapy; D060787:Neoplasm Grading; D010338:Pathology, Clinical; D010819:Physician's Role; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor