title: Triterpenes as α-glucosidase inhibitors from Fagus hayatae.
abstract: Triterpenoids, 1-3, 8 and 9, along with 24 known compounds were isolated from leaves and twigs of Fagus hayatae. Of these, compound 1, 1,10-seco-3β,10α,23-trihydroxyolean-12-ene-1,28-dioic acid 1,23-lactone, possesses a hitherto unknown 1,10-seco-oleanane skeleton. In addition, 2,3-seco-20(29)-lupene-2,3-dioic acid (16), previously described as a synthetic product, is now established as a plant natural product; the neolignan-9'-O-rhamnoside 19 is also characterized herein. Their structures were deduced mainly by 1D and 2D NMR spectroscopic analyses. Seven of these compounds possess moderate inhibitory activity against α-glucosidase type IV (Bacillus stearothermophilus).
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10051, Taiwan, ROC.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Lai
authors.forename: Chien-Kuang
authors.initials: CK
authors.lastname: Chen
authors.forename: Sheng-Fa
authors.initials: SF
authors.lastname: Tsai
authors.forename: Shoei-Sheng
authors.initials: SS
authors.lastname: Lee
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029964:Fagus / Q000737:chemistry*; D001411:Geobacillus stearothermophilus / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D014315:Triterpenes