title: Histone post-translational modifications associated to BAALC expression in leukemic cells.
abstract: BAALC expression is an indicator of aggressiveness in acute myelogenous leukemia (AML). Overexpression of this gene is associated to poor of clinical outcome. It is known that post-translational histone modifications control gene transcription. Thus, here we have investigated BAALC expression and post-translational histone modifications in leukemia cell lines. We show that Kasumi-6 and Kyo cells have high and low BAALC mRNA levels, respectively. Moreover, we demonstrate that these cell lines present distinct profiles in terms of histone post-translational modifications (H3K9K14 acetylation, H3K4 trimethylation and H3K23 trimethylation) at the level of BAALC promoter. These findings, in light of recent data on how histone post-translational modifications control gene expression, indicate that BAALC gene is "paused" and that in leukemia cells its transcription can be activated or repressed by mechanisms acting on epigenetic marks.
authors.affiliation: Istituto di Genetica Medica, Azienda Ospedaliero-Universitaria S. Maria della Misericordia Udine, Italy. franzoni.alessandra@aoud.sanita.fvg.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Franzoni
authors.forename: Nadia
authors.initials: N
authors.lastname: Passon
authors.forename: Dora
authors.initials: D
authors.lastname: Fabbro
authors.forename: Mario
authors.initials: M
authors.lastname: Tiribelli
authors.forename: Daniela
authors.initials: D
authors.lastname: Damiani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damante
mesh_terms: D045744:Cell Line, Tumor; D044127:Epigenesis, Genetic; D015973:Gene Expression Regulation, Leukemic; D006657:Histones / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational
chemical_list: C442828:BAALC protein, human; D006657:Histones; D009363:Neoplasm Proteins