title: Promoting the formation of tetramolecular G-quadruplexes under freezing condition.
abstract: In the study, we demonstrated that freezing was able to facilitate the short DNA strand T(4)G(4) to self-assemble into a tetramolecular G-quadruplex with a low DNA concentration in the absence of any ligand, providing a fast approach to configure intermolecular G-quadruplexes. The fast formation of intermolecular G-quadruplexes may offer a convenient tool.
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, PR China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhai
authors.forename: Minggang
authors.initials: M
authors.lastname: Deng
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D004247:DNA / Q000737:chemistry*; D005615:Freezing; D054856:G-Quadruplexes
chemical_list: D004247:DNA