title: Cardiac cell therapy: pre-conditioning effects in cell-delivery strategies.
abstract: Stem-cell therapy holds great promise for the treatment of ischemic heart disease. However, the benefit of cardiac cell therapy has not yet been proven in long-term clinical trials. Poor engraftment and survival of transplanted cells is one of the major concerns for the successful application of stem cells in cardiac cell therapy. Cell and cardiac pre-conditioning are now being explored as new approaches to support cell survival and enhance the therapeutic efficacy. In this paper, we summarize the state-of-the-art methods of cell delivery and cell survival post-delivery, with a focus on the pre-conditioning approaches that have been attempted to support the survival of transplanted cells.
authors.affiliation: Cardiovascular Center, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China. pumcwu@yahoo.com.cn
authors.forename: Kai Hong
authors.initials: KH
authors.lastname: Wu
authors.forename: Xu Ming
authors.initials: XM
authors.lastname: Mo
authors.forename: Zhong Chao
authors.initials: ZC
authors.lastname: Han
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
mesh_terms: D016923:Cell Death; D002454:Cell Differentiation; D002470:Cell Survival; D002986:Clinical Trials as Topic; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D017202:Myocardial Ischemia / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D019172:Transplantation Conditioning / Q000379:methods*; D016896:Treatment Outcome