title: Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice.
abstract: The anticonvulsant effects of D-cycloserine, which is a partial agonist of the glycine/N-methyl-D-aspartate (NMDA) receptor, and L-701,324, which is a selective and potent antagonist that acts at the glycine site, were studied in electroshock-induced seizures in mice. Glycine, which is a natural full agonist that acts at the glycine site, enhanced the seizure threshold-increasing effect of D-cycloserine. L-701,324 produced a marked increase in the seizure threshold, which was significantly reversed by the administration of glycine. These results suggest that indirect glycine/NMDA antagonistic mechanisms may be responsible for the anticonvulsant action of D-cycloserine.
authors.affiliation: Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, PL 20-033 Lublin, Poland. piotr.wlaz@umcs.lublin.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Wlaź
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology*; D004597:Electroshock; D005998:Glycine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015363:Quinolones / Q000494:pharmacology*; D018009:Receptors, Glycine / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D015363:Quinolones; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine; C094635:L 701324; D005998:Glycine