title: Candidaemia in a European Paediatric University Hospital: a 10-year observational study.
abstract: In this retrospective observational study covering 1998 to 2008, 32 patients (mean age: 7.50 years) were identified that had 35 episodes of candidaemia (0.47 cases/1000 hospital discharges). Cancer/allogeneic haematopoietic stem cell transplantation (43%) and congenital malformations/syndromes (21%) were the predominant underlying conditions. Central venous catheterization (90%), a history of antibacterial therapy (69%) and previous bacteraemia (54%) were frequent comorbidities. Candida albicans (46%) was most common, followed by Candida parapsilosis (17%) and Candida glabrata (14%). Resistance was infrequent and limited to non-albicans Candida spp. The 30-day and 100-day mortality rates were 11.4%.
authors.affiliation: Department of Paediatric Haematology/Oncology, University Children's Hospital Münster, Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Tragiannidis
authors.forename: W
authors.initials: W
authors.lastname: Fegeler
authors.forename: G
authors.initials: G
authors.lastname: Rellensmann
authors.forename: V
authors.initials: V
authors.lastname: Debus
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: I
authors.initials: I
authors.lastname: Hoernig-Franz
authors.forename: K
authors.initials: K
authors.lastname: Siam
authors.forename: Z-D
authors.initials: ZD
authors.lastname: Pana
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: A H
authors.initials: AH
authors.lastname: Groll
mesh_terms: D000293:Adolescent; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D058387:Candidemia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D005060:Europe / Q000453:epidemiology; D005260:Female; D006776:Hospitals, Pediatric; D006785:Hospitals, University; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D055815:Young Adult