title: [Use of autofluorescence bronchoscopy and spectrometry in the diagnosis of central lung cancer].
abstract: The paper evaluates the available data as well as our own on use of autofluorescence bronchoscopy in conjunction with spectrometric examination. We used qualitative and quantitative assessment of images obtained by conventional and autofluorescence (ClearVu Elite) means in real time. Our double-stage study evaluated sensitivity and specificity of autofluorescence bronchoscopy in diagnosing lung cancer as well as constructed spectrometric curves (ROC) and areas under them (AUC). Endoscopy was used in 171 patients with central lung cancer. Autofluorescence bronchoscopy established high sensitivity--94.74% (95%CI: 80.9-99%) and sufficient specificity--79.95% (95%CI: 75.8-83.6%). Application of a wide range of spectrometric coefficients contributed to high specificity thus reducing the number of biopsies as well as the injury from the treatment. The AUC for a best predictive index was 0.89 (99%: 0.83-0.95).
authors.forename: A A
authors.initials: AA
authors.lastname: Barchuk
authors.forename: A I
authors.initials: AI
authors.lastname: Arsen'ev
authors.forename: E V
authors.initials: EV
authors.lastname: Levchenko
authors.forename: A S
authors.initials: AS
authors.lastname: Barchuk
authors.forename: A M
authors.initials: AM
authors.lastname: Shcherbakov
authors.forename: D E
authors.initials: DE
authors.lastname: Matsko
authors.forename: E A
authors.initials: EA
authors.lastname: Zheldunova
authors.forename: A O
authors.initials: AO
authors.lastname: Nefëdov
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: S A
authors.initials: SA
authors.lastname: Tarkov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Aristidov
authors.forename: K E
authors.initials: KE
authors.lastname: Gagua
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001999:Bronchoscopy / Q000379:methods; D005260:Female; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis