title: [Study of genetic polymorphisms in the tumor necrosis factor α promoter region in Spanish patients with psoriasis].
abstract: BACKGROUND
  Several studies have reported an association between tumor necrosis factor α (TNF-α) polymorphisms and inflammatory diseases such as psoriasis vulgaris and psoriatic arthritis, although the results vary according to the population studied. No studies have been performed in the Spanish population.
  
  
  OBJECTIVE
  To analyze the polymorphisms of the promoter region of the TNF-α gene in patients with moderate to severe psorasis and to identify potential differences in genotype compared to a group of healthy volunteers.
  
  
  METHODS
  Eighty-nine patients with moderate to severe psoriasis and 76 healthy controls with no personal or family history of psoriasis were selected. Polymorphisms of the TNF-α promoter region of both groups were genotyped.
  
  
  RESULTS
  We observed a higher prevalence of the genotype with both wild-type alleles at positions -238 (GG genotype, 86.5% vs 70.4%, respectively) and -1031 (TT genotype, 80.2% vs 45.8%, respectively) in patients compared to the healthy control group. The differences at positions -308 and -857 were not significant.
  
  
  CONCLUSIONS
  There are differences in polymorphisms at positions -238 and -1031 in patients with moderate to severe psoriasis compared to healthy volunteers. This observation provides further support for the importance of the part that TNF-α plays in the pathophysiology of this disease.
authors.affiliation: Servicio de Dermatología, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Madrid, España. egallo@aedv.es
authors.forename: E
authors.initials: E
authors.lastname: Gallo
authors.forename: T
authors.initials: T
authors.lastname: Cabaleiro
authors.forename: M
authors.initials: M
authors.lastname: Román
authors.forename: F
authors.initials: F
authors.lastname: Abad-Santos
authors.forename: E
authors.initials: E
authors.lastname: Daudén
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D011565:Psoriasis / Q000235:genetics*; D013030:Spain; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha