title: Preeclampsia, hypoxia, thrombosis, and inflammation.
abstract: Reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes. In this review, we detail these effects and their relationship to preeclampsia (PE) and intrauterine growth restriction (IUGR).
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Shamshirsaz
authors.forename: Michael
authors.initials: M
authors.lastname: Paidas
authors.forename: Graciela
authors.initials: G
authors.lastname: Krikun
mesh_terms: D042501:Angiogenic Proteins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D004717:Endometrium / Q000166:cytology / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010922:Placenta Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D042501:Angiogenic Proteins; D015415:Biomarkers; D001779:Blood Coagulation Factors; D003165:Complement System Proteins; D002394:Catechol O-Methyltransferase