title: Rapid reversal of uremic neuropathy following renal transplantation in an adolescent.
abstract: Clinical and pathologic studies on adults with uremic neuropathy are numerous, but less is known about this disorder in children and adolescents. We report the clinical, electrophysiologic, and pathologic findings in an adolescent female with uremic neuropathy. Electrophysiologic findings were consistent with a primarily axonal sensorimotor polyneuropathy. Sural nerve biopsy revealed areas of focal depletion in myelin sheaths and loss of axons. Axonal degeneration with secondary myelin changes appears to be the characteristic pathology in this case, one of the youngest to our knowledge for which nerve biopsy data are available. Our patient experienced dramatic recovery after renal transplantation, similar to the reports of older patients.
authors.affiliation: Department of Neurology, Lahey Clinic Medical Center, Burlington, MA, USA.
authors.forename: Doreen T
authors.initials: DT
authors.lastname: Ho
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Rodig
authors.forename: Heung B
authors.initials: HB
authors.lastname: Kim
authors.forename: Hart G W
authors.initials: HG
authors.lastname: Lidov
authors.forename: Frederic D
authors.initials: FD
authors.lastname: Shapiro
authors.forename: G Praveen
authors.initials: GP
authors.lastname: Raju
authors.forename: Peter B
authors.initials: PB
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D001369:Axons / Q000473:pathology; D001706:Biopsy / Q000379:methods; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000628:therapy*; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D009431:Neural Conduction; D011115:Polyneuropathies / Q000209:etiology / Q000628:therapy*; D051437:Renal Insufficiency / Q000628:therapy*; D013497:Sural Nerve / Q000473:pathology; D016896:Treatment Outcome; D014511:Uremia / Q000628:therapy*