title: [Research progress and application of BCR/ABL transgenic animal model].
abstract: Transgenic animal model provide a good platform to research the pathogenesis and therapy of chronic myelogenous leukemia (CML). To date, a number of BCR/ABL transgenic animal models have been established using different promoter or tetracycline-controlling system. Some of them appear the characteristics of human CML, which have contributed greatly to research the pathogenesis and therapy of CML. In this article, the researching progress, advantage and drawback, application of BCR/ABL transgenic animal model are reviewed.
authors.affiliation: Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zhu
authors.forename: Yuan-Zhan
authors.initials: YZ
authors.lastname: Wang
authors.forename: Fan-Yi
authors.initials: FY
authors.lastname: Meng
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive
chemical_list: D016044:Fusion Proteins, bcr-abl