title: Two cases of severe sepsis caused by Bacillus pumilus in neonatal infants.
abstract: Bacillus pumilus is an environmental contaminant that has been rarely associated with clinical infections. Here, two cases of severe sepsis caused by B. pumilus are described in two full-term neonates; one in a female infant with no factors predisposing her to infection and the other in a male infant requiring mechanical ventilation and an intravenous catheter. In both cases, the micro-organism was recovered from repeated blood cultures and was identified using biochemical assays and 16S rRNA gene sequencing. Both infants were successfully treated with vancomycin. This report reveals the potential role of B. pumilus as a bloodstream pathogen during infancy.
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.|Department of Microbiology, Saint Panteleimon General Hospital, Nicea, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Kimouli
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Vrioni
authors.affiliation: Neonatal Intensive Care Unit, Saint Panteleimon General Hospital, Nicea, Greece.
authors.forename: Magdalini
authors.initials: M
authors.lastname: Papadopoulou
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Koumaki
authors.affiliation: Department of Microbiology, Saint Panteleimon General Hospital, Nicea, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Petropoulou
authors.affiliation: Neonatal Intensive Care Unit, Saint Panteleimon General Hospital, Nicea, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Gounaris
authors.affiliation: Department of Medical Microbiology, University Medical Centre Groningen, Rijksuniversiteit Groningen, The Netherlands.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Friedrich
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakris
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001407:Bacillus / Q000145:classification* / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology*; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin