title: Vitamin D supplementation does not increase immunogenicity of seasonal influenza vaccine in HIV-infected adults.
abstract: The influence of vitamin D on influenza vaccine immunogenicity in HIV was assessed using data from a phase 3, randomized trial conducted during the 2008-2009 influ-enza season. Thirty-three percent of participants were on supplemental vitamin D at baseline. Neither seroconversion nor seroprotection were predicted by vitamin D use for any of the 3 vaccine strains. There is no evidence of improved influenza vaccine immunogenicity with vitamin D supplementation in this HIV-positive population.
authors.affiliation: The Ottawa Hospital Division of Infectious Diseases, University of Ottawa, Ottawa, Canada. ccooper@ottawahospital.on.ca
authors.forename: Curtis
authors.initials: C
authors.lastname: Cooper
authors.forename: Anona
authors.initials: A
authors.lastname: Thorne
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D019587:Dietary Supplements; D005260:Female; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage / Q000276:immunology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014807:Vitamin D