title: Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases.
abstract: OBJECTIVE
  To assess whether circulating soluble CD95 ligand (sCD95L) levels are associated with recurrence-free survival (RFS) in patients with synchronous colorectal liver metastases.
  
  
  METHODS
  Blood samples were obtained from 62 patients with synchronous colorectal liver metastases before and after liver surgery. Serum sCD95L levels were determined using enzyme-linked immunosorbent assay (ELISA). Cox regression analysis was performed to determine the correlation between sCD95L levels and RFS and overall survival (OS).
  
  
  RESULTS
  Median follow-up was 33 months. High pre-operative sCD95L levels were associated with poor RFS and OS in univariable (p=0.019 and p=0.020) and multivariable analyses (p=0.020 and p=0.003).
  
  
  CONCLUSIONS
  Preoperatives CD95L is a potential prognostic factor for RFS and OS of patients undergoing surgery for synchronous colorectal liver metastases. Low preoperatives CD95L levels may help identify a subgroup of patients with synchronous liver metastases that are likely to benefit from liver surgery.
authors.affiliation: Department of Surgery, G.04.228, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
authors.forename: Frederik J H
authors.initials: FJ
authors.lastname: Hoogwater
authors.forename: Nikol
authors.initials: N
authors.lastname: Snoeren
authors.forename: Maarten W
authors.initials: MW
authors.lastname: Nijkamp
authors.forename: Amy C
authors.initials: AC
authors.lastname: Gunning
authors.forename: Winan J
authors.initials: WJ
authors.lastname: VAN Houdt
authors.forename: Menno T
authors.initials: MT
authors.lastname: DE Bruijn
authors.forename: Emile E
authors.initials: EE
authors.lastname: Voest
authors.forename: Richard
authors.initials: R
authors.lastname: VAN Hillegersberg
authors.forename: Onno
authors.initials: O
authors.lastname: Kranenburg
authors.forename: Inne H M Borel
authors.initials: IH
authors.lastname: Rinkes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology*; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence
chemical_list: D014408:Biomarkers, Tumor; D053222:Fas Ligand Protein