title: Traditional uses, phytochemistry and pharmacology of Clerodendron glandulosum Coleb--a review.
abstract: Present review for the first time provides a complete botanical description and information on ethnomedicinal uses of Clerodendron glandulosum.Coleb (CG; Fam, Verbenaceae). Recent studies conducted from our laboratory provide pharmacological evidence for its anti-hypertensive, anti-diabetic and anti-obesity potentials. Further, its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hepatoprotective and free radical scavenging abilities along with its acute and sub-chronic toxicological evaluations are also reported from our laboratory. In keeping with its traditional uses, CG extract was capable of ameliorating experimentally induced hypertension, diabetes and obesity. Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential. Non-toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties. The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension, diabetes and obesity along with anti oxidant potential and beneficial effects against non alcoholic steatohepatitis.
authors.affiliation: Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The MS University of Baroda, Vadodara, Gujarat, India.
authors.forename: Ravirajsinh N
authors.initials: RN
authors.lastname: Jadeja
authors.forename: Menaka C
authors.initials: MC
authors.lastname: Thounaojam
authors.forename: Thouchom Brojendro
authors.initials: TB
authors.lastname: Singh
authors.forename: Ranjitsinh V
authors.initials: RV
authors.lastname: Devkar
authors.forename: Av
authors.initials: A
authors.lastname: Ramachandran
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D050197:Atherosclerosis / Q000517:prevention & control; D032409:Clerodendrum / Q000737:chemistry; D019317:Evidence-Based Medicine; D005234:Fatty Liver / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007194:India; D008519:Medicine, Traditional; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D000959:Antihypertensive Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020011:Protective Agents