title: Imbalance between bone formation and resorption in hematopoietic stem/progenitor cells mobilization.
abstract: Mobilization is now used worldwide to collect large numbers of hematopoietic stem and progenitor cells (HSPCs) for transplantation. It is the result of a process impelling stem cell detachment from their niche, meanwhile gaining cellular features required for proliferation and migration. Mobilization remarkably affects the endosteal stem cell niche, which must be adjusted to support retention and quiescence versus mobilization and proliferation. The endosteal bone-lining cells, osteoblasts and osteoclasts, not only maintain bone balance but also participate in HSPC mobilization. The aim of this paper was to review recent advances in our understanding of HSPC mobilization and how these advances are being translated into the clinic for more efficacious mobilizing agents.
authors.affiliation: Hematological Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: S-D
authors.initials: SD
authors.lastname: Li
authors.forename: Q-L
authors.initials: QL
authors.lastname: Zhai
authors.forename: L-G
authors.initials: LG
authors.lastname: Qiu
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000378:metabolism*; D002450:Cell Communication; D002465:Cell Movement; D049109:Cell Proliferation; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000378:metabolism*; D010012:Osteogenesis; D015398:Signal Transduction; D055153:Stem Cell Niche