title: Magnesium sulfate as an oral contrast medium in magnetic resonance imaging of the small intestine.
abstract: BACKGROUND
  To explore the use of magnesium sulfate (MgSO4) as an oral contrast medium (CM) in MRI of the small intestine.
  
  
  METHODS
  By comparing MgSO4 SNRs at different concentrations, we determined that 2.5% MgSO4 is the ideal concentration for small bowel MRI. Twenty volunteers underwent MRI after drinking 2.5% MgSO4. Thirty-one patients with clinical suspicion of small intestinal pathology underwent both MRI and the air-barium contrast examination. The patient's tolerance, side effects and complications were noted.
  
  
  RESULTS
  2.5% MgSO4 can decrease the absorption of water and fully fill the enteric cavity, thereby increasing the contrast between the intestinal wall and lumen and facilitating radiographic examination of the small bowel. The mean diameter of the small intestine was 19.8±1.21 mm in the 20 volunteers consuming 2.5% MgSO4 and 12.7±0.84 mm in the 20 volunteers given water. There was a significant difference (P<0.05) between the diameters of the small intestine of the two groups. But there were no significant differences (P>0.05) in side effects between MgSO4 and water groups. Small intestinal MRI was successfully performed in all 31 patients, who were also examined by the double contrast barium, which gave almost identical diagnoses to MRI in all cases except for 1 patient with small intestinal hemorrhage.
  
  
  CONCLUSIONS
  MRI with 2.5% MgSO4 can demonstrate intestinal abnormalities. Therefore, 2.5% MgSO4 solution is an ideal oral CM for small bowel MRI.
authors.affiliation: Department of Diagnostic Imaging, Shandong Qianfoshan Hospital, Jingshi Street 16766, Jinan, Shandong Province 250014, PR China. hansenschie@163.com
authors.forename: Hao
authors.initials: H
authors.lastname: Shi
authors.forename: Cun
authors.initials: C
authors.lastname: Liu
authors.forename: Hong Yu
authors.initials: HY
authors.lastname: Ding
authors.forename: Chun Wei
authors.initials: CW
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001466:Barium Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics; D003287:Contrast Media / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis*; D007421:Intestine, Small; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate; D008278:Magnesium Sulfate