title: Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis.
abstract: OBJECTIVE
  Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS.
  
  
  METHODS
  IBS patients of the diarrhea-predominant (IBS-D) and of the constipation-predominant subgroup (IBS-C), patients with inactive UC and healthy subjects were enrolled. Gut permeability was evaluated by measuring 24-hour urine excretion of orally administered (51)Cr-EDTA. Clinical symptoms were evaluated in IBS-D patients and correlated to colonic permeability.
  
  
  RESULTS
  There was a significant decrease in the proximal small intestinal permeability in IBS-C patients compared to controls (0.26 ± 0.05 vs. 0.63 ± 0.1%; p < 0.05). Distal small intestinal permeability showed no significant difference in the studied group of patients compared to controls. Colonic permeability of IBS-D and inactive UC patients was significantly increased compared to controls (2.68 ± 0.35 and 3.74 ± 0.49 vs. 1.04 ± 0.18%; p < 0.05, p < 0.001). Colonic permeability of IBS-D patients correlated with stool frequency.
  
  
  CONCLUSIONS
  Elevated gut permeability is localized to the colon both in IBS-D and in inactive UC patients.
authors.affiliation: First Department of Internal Medicine, University of Szeged, Szeged, Hungary. krisztina.gecse@gmail.com
authors.forename: Krisztina
authors.initials: K
authors.lastname: Gecse
authors.forename: Richárd
authors.initials: R
authors.lastname: Róka
authors.forename: Teréz
authors.initials: T
authors.lastname: Séra
authors.forename: András
authors.initials: A
authors.lastname: Rosztóczy
authors.forename: Anita
authors.initials: A
authors.lastname: Annaházi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Izbéki
authors.forename: Ferenc
authors.initials: F
authors.lastname: Nagy
authors.forename: Tamás
authors.initials: T
authors.lastname: Molnár
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szepes
authors.forename: László
authors.initials: L
authors.lastname: Pávics
authors.forename: Lionel
authors.initials: L
authors.lastname: Bueno
authors.forename: Tibor
authors.initials: T
authors.lastname: Wittmann
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications / Q000503:physiopathology*; D003106:Colon / Q000502:physiology*; D003967:Diarrhea / Q000150:complications / Q000503:physiopathology*; D004492:Edetic Acid / Q000008:administration & dosage / Q000652:urine; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010539:Permeability
chemical_list: D004492:Edetic Acid