title: Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites.
abstract: We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes.
authors.affiliation: Utrecht Institute for Pharmaceutical Sciences, Medicinal Chemistry & Chemical Biology, Faculty of Science, University of Utrecht, Utrecht, The Netherlands.
authors.forename: H Bauke
authors.initials: HB
authors.lastname: Albada
authors.forename: Fouad
authors.initials: F
authors.lastname: Soulimani
authors.forename: Hans J F
authors.initials: HJ
authors.lastname: Jacobs
authors.forename: Cees
authors.initials: C
authors.lastname: Versluis
authors.forename: Bert M
authors.initials: BM
authors.lastname: Weckhuysen
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry* / Q000378:metabolism; D001372:Aza Compounds / Q000737:chemistry* / Q000378:metabolism; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D020134:Catalytic Domain; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000378:metabolism; D006639:Histidine / Q000737:chemistry* / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism
chemical_list: D001372:Aza Compounds; D056831:Coordination Complexes; D006574:Heterocyclic Compounds, 2-Ring; D008667:Metalloproteins; C539946:triazacyclophane; D001224:Aspartic Acid; D006639:Histidine; D003300:Copper; D010100:Oxygen