title: [Antiherpesviral activity of acycloguanosine H-phosphonate in experiments using laboratory animals].
abstract: A study of the antiherpesviral activity of acycloguanosine (ACG) H-phosphonate (ACG-P) on a model of fatal herpesvirus infection in inbred BALB/c albino mice has established that ACG-P reduces death rates in the animals, considerably increases their average lifespan, and significantly decreases brain virus titers with both 60% mortality in the control and 92% mortality in the control group. There was also a significant inhibition of herpes simplex virus type 1 (HSV-1) replication in the brain tissue of animals receiving ACG-P on a model of ACG-resistant HSV-1/L2/RACG(TK-).
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: M V
authors.initials: MV
authors.lastname: Ias'ko
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Skoblov
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000821:virology; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008168:Lung / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D063065:Organophosphonates / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C550134:acycloguanosine H-phosphonate; D000212:Acyclovir