title: [Adhesion molecules expressed in vascular endothelial cells in natural immunity against viral infections].
abstract: Cell adhesion molecules (CAM) expressed in vascular endothelium ensure integrity of the endothelial layer, recruitment and transmigration of leukocytes. Being receptors of many viruses, they play a role in immune control and infectious processes. Monoclonal anti-ICAM-1 antibodies enhance infection of primary human umbilical vein endothelial cell (HUVEC) cultures with HIV-1 due to incorporation into virions. IFN-gamma activates expression of ICAM-1 on HIV-infected HUVEC and thereby promotes binding of this molecule to complementary molecules on a greater number of sensitive cells, virion transfer onto them, and broad dissemination of the virus. Recombinant human IFN-alpha, IFN-beta and IFN-gamma influence (activate, inhibit) CAM shedding from HUVEC both intact and infected wit HSV-1. Activated shedding in the blood stream due to competition between soluble and endothelial CAM slows down recruitment and transmigration of leukocytes, i.e. regulates inflammation. CAM incorporated in microparticles can influence a wide spectrum of pathological processes Endothelial CAM may be a target for the delivery of pharmaceuticals for the treatment of vascular (including infectious) pathology.
authors.forename: O N
authors.initials: ON
authors.lastname: Shcheglovitova
authors.forename: N N
authors.initials: NN
authors.lastname: Skliankina
authors.forename: A A
authors.initials: AA
authors.lastname: Babaiants
authors.forename: I S
authors.initials: IS
authors.lastname: Frolova
authors.forename: D L
authors.initials: DL
authors.lastname: Beliaev
authors.forename: F I
authors.initials: FI
authors.lastname: Ershov
mesh_terms: D000911:Antibodies, Monoclonal / Q000378:metabolism; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000276:immunology*; D005544:Forecasting; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000378:metabolism; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1