title: [Variability in the frequency of TCR-mutant lymphocytes associated with gene polymorphisms in women living in radiation-polluted areas].
abstract: The paper presents the results of an association study of a predisposition to increased somatic mutagenesis detected by the test for TCR-mutant lymphocytes (CD3-CD4+ phenotype). A study group consisted of 251 women who lived in the towns polluted by radionuclides after the Chernobyl accident and had estrogen-dependent reproductive system diseases (uterine myoma, fibrocystic mastopathy). The carriage of minor alleles in the genes (CYP1A1, GSTM1, and ABCB1) of all three stages of detoxification of xenobiotics was associated with the rise in the spontaneous frequency of TCR-mutant cells. Overweight modified the genotype (at CYP1A1 and GSTT1 loci) - environment interaction. When background radiation became higher, the contribution of minor alleles in the CYP1A1 genes to the instability recorded as the elevated frequency of TCR-mutant cells increased.
authors.forename: L E
authors.initials: LE
authors.lastname: Sal'nikova
authors.forename: I A
authors.initials: IA
authors.lastname: Zamulaeva
authors.forename: A S
authors.initials: AS
authors.lastname: Saenko
authors.forename: S K
authors.initials: SK
authors.lastname: Abilev
authors.forename: A V
authors.initials: AV
authors.lastname: Rubanovich
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000328:Adult; D047852:Chernobyl Nuclear Accident; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D045647:DNA Glycosylases / Q000235:genetics; D005260:Female; D005348:Fibrocystic Breast Disease / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000235:genetics*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011848:Radioactive Pollutants; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012426:Russia; D014455:Ukraine; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D011848:Radioactive Pollutants; D011948:Receptors, Antigen, T-Cell; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human