title: Immunopathogenesis in Chlamydia trachomatis Infected Women.
abstract: We examine the Chlamydia trachomatis (Ct) immunopathogenesis on the basis of the complex interaction between host immune response and virulence microorganism factors. Ct infection can be asymptomatic or may produce an inflammation elicited and preserved by reinfections or persistent infections. We discuss the host polymorphisms that, with their anti- or proinflammatory effects, determine the course of the disease. We also took into account the inflammation process following the Chlamydia illness and the role of both CD4 cells producing IFN-γ and CD8 cells with their cytokines production. The crucial role of Ct-hsp60 and the double activity (either damaging or preserving from some kinds of tumors) of anti-Ct-hsp60 antibodies are considered.
authors.affiliation: Department of Infectious Diseases, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Mascellino
authors.forename: Priscilla
authors.initials: P
authors.lastname: Boccia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Oliva