title: Donor dendritic cell proliferation and migration in hepatic allografts by pretransplant intraportal infusion of recipient blood into donor rats.
abstract: BACKGROUND
  We have reported that recipient blood transfusion pretransplant prolongs hepatic allograft survival in rats. This study further investigated the mechanisms of the phenomenon.
  
  
  METHODS
  Male LEW and ACI rats were used as liver transplant recipients and donors, respectively. Experimental animals were divided into control; treatment experimental; and intraportally transfused (1 mL recipient blood) at 7 days before transplantation.
  
  
  RESULTS
  Rat survival time was significantly longer among the experiment versus the control group. A large number of donor-source dendritic cells were detected among infiltrating cells in the liver and spleen in the experimental group.
  
  
  CONCLUSIONS
  We concluded that the prolonged survival of hepatic allograft in these rats was associated with donor dendritic cell proliferation and migration.
authors.affiliation: Department of General Surgery, the First Hospital of China Medical University, Shenyang, China. wangfs2006@yahoo.com.cn
authors.forename: F S
authors.initials: FS
authors.lastname: Wang
authors.forename: J-L
authors.initials: JL
authors.lastname: Zhang
authors.forename: Z G
authors.initials: ZG
authors.lastname: Shao
authors.forename: Y F
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D002465:Cell Movement; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000276:immunology / Q000637:transplantation*; D006085:Graft Survival; D008099:Liver / Q000276:immunology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous