title: Synthesis of the C21-C34 fragment of antascomicin B.
abstract: The C21-C34 fragment of the potent FKBP12-binding macrolide antascomicin B was prepared using Ireland-Claisen and allylic diazene rearrangements to establish the C26/C27 and the C23 stereocenters, respectively. Directed hydrogenation installed the C29 β-configuration. The fragment possesses 7 of the 11 fixed stereocenters contained in the natural product.
authors.affiliation: University of Arkansas, 119 Chemistry Building, Fayetteville, AR 72701, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Hutchison
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Gibson
authors.forename: David T
authors.initials: DT
authors.lastname: Williams
authors.forename: Matthias C
authors.initials: MC
authors.lastname: McIntosh