title: Further evidence for amyloid deposition in clinical pancreatic islet grafts.
abstract: BACKGROUND
  The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells.
  
  
  METHODS
  Sections from liver material from four deceased islet-bearing recipients have been scrutinized for the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have been published previously.
  
  
  RESULTS
  With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplanted into the liver in three of four patients with type 1 diabetes.
  
  
  CONCLUSIONS
  The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be an important cause of progressing β-cell dysfunction in clinically transplanted islets.
authors.affiliation: Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. gunilla.westermark@mcb.uu.se
authors.forename: Gunilla T
authors.initials: GT
authors.lastname: Westermark
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Davalli
authors.forename: Antonio
authors.initials: A
authors.lastname: Secchi
authors.forename: Franco
authors.initials: F
authors.lastname: Folli
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kin
authors.forename: Christian
authors.initials: C
authors.lastname: Toso
authors.forename: A M James
authors.initials: AM
authors.lastname: Shapiro
authors.forename: Olle
authors.initials: O
authors.lastname: Korsgren
authors.forename: Gunnar
authors.initials: G
authors.lastname: Tufveson
authors.forename: Arne
authors.initials: A
authors.lastname: Andersson
authors.forename: Per
authors.initials: P
authors.lastname: Westermark
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058228:Islet Amyloid Polypeptide / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects* / Q000401:mortality / Q000473:pathology / Q000502:physiology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D045706:Proprotein Convertase 2 / Q000378:metabolism; D014019:Tissue Donors
chemical_list: D058228:Islet Amyloid Polypeptide; D045706:Proprotein Convertase 2