title: Heat makes a difference in activity-based anorexia: a translational approach to treatment development in anorexia nervosa.
abstract: OBJECTIVE
  To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals.
  
  
  METHODS
  Two studies are reported in which female rats were submitted to food restriction and free access to an activity wheel either separately or in combination under changing (21-32 °C) or constant AT (21 °C).
  
  
  RESULTS
  Warming ABA animals reversed running activity, preserved food-intake, and enabled female rats to recover from acute weight loss. Moreover, sedentary food-restricted warmed rats maintained a body weight equivalent to the levels of animals housed at standard AT in spite of 20% reduced food-intake.
  
  
  CONCLUSIONS
  The replication on female rats corroborates the effect previously reported for males, which is indicative of the robust effect of AT in recovering rats from ABA. The findings reported here represent strong preclinical evidence in favor of heat supply as a useful adjunctive component for the treatment of anorexia nervosa (AN).
authors.affiliation: Departamento de Psicología Clinica y Psicobiología, Facultad de Psicología, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Cerrato
authors.forename: Olaia
authors.initials: O
authors.lastname: Carrera
authors.forename: Reyes
authors.initials: R
authors.lastname: Vazquez
authors.forename: Enrique
authors.initials: E
authors.lastname: Echevarría
authors.forename: Emilio
authors.initials: E
authors.lastname: Gutierrez
mesh_terms: D000818:Animals; D000856:Anorexia Nervosa / Q000503:physiopathology / Q000628:therapy; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005260:Female; D006361:Heating; D006358:Hot Temperature; D006948:Hyperkinesis / Q000503:physiopathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley