title: Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types.
abstract: The cutaneous beta human papillomavirus (beta HPV) types appear to be involved in skin carcinogenesis. However, only a few beta HPVs have been investigated so far. Here, we compared the properties of E6 and E7 oncoproteins from six uncharacterized beta HPVs (14, 22, 23, 24, 36, 49). Only HPV49 E6 and E7 immortalized primary human keratinocytes and efficiently deregulated the p53 and pRb pathways. Furthermore, HPV49 E6, similarly to E6 from the oncogenic HPV16, promoted p53 degradation.
authors.affiliation: IARC, Lyon, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Cornet
authors.forename: Véronique
authors.initials: V
authors.lastname: Bouvard
authors.forename: Maria Saveria
authors.initials: MS
authors.lastname: Campo
authors.forename: Miranda
authors.initials: M
authors.lastname: Thomas
authors.forename: Lawrence
authors.initials: L
authors.lastname: Banks
authors.forename: Lutz
authors.initials: L
authors.lastname: Gissmann
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lamartine
authors.forename: Bakary S
authors.initials: BS
authors.lastname: Sylla
authors.forename: Rosita
authors.initials: R
authors.lastname: Accardi
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
mesh_terms: D052686:Betapapillomavirus / Q000235:genetics / Q000502:physiology*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism*; D050725:Papillomavirus E7 Proteins / Q000235:genetics / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D016159:Tumor Suppressor Protein p53