title: Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
abstract: The advent of vaccines targeting drugs of abuse heralded a fundamentally different approach to treating substance-related disorders. In contrast to traditional pharmacotherapies for drug abuse, vaccines act by sequestering circulating drugs and terminating the drug-induced 'high' without inducing unwanted neuromodulatory effects. Drug-targeting vaccines have entered clinical evaluation, and although these vaccines show promise from a biomedical viewpoint, the ethical and socioeconomic implications of vaccinating patients against drugs of abuse merit discussion within the scientific community.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 582, La Jolla, California 92037-1000, USA. kdjanda@scripps.edu
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Treweek
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000276:immunology; D014612:Vaccines / Q000627:therapeutic use*
chemical_list: D000906:Antibodies; D014612:Vaccines