title: Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy.
abstract: OBJECTIVE
  To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB).
  
  
  METHODS
  Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship.
  
  
  RESULTS
  The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ≥ 1, 2, 3, 4 and 5 years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status.
  
  
  CONCLUSIONS
  The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
authors.affiliation: Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada. mcw.sun@umontreal.ca
authors.forename: Maxine
authors.initials: M
authors.lastname: Sun
authors.forename: Firas
authors.initials: F
authors.lastname: Abdollah
authors.forename: Marco
authors.initials: M
authors.lastname: Bianchi
authors.forename: Quoc-Dien
authors.initials: QD
authors.lastname: Trinh
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
authors.forename: Claudio
authors.initials: C
authors.lastname: Jeldres
authors.forename: Zhe
authors.initials: Z
authors.lastname: Tian
authors.forename: Jens
authors.initials: J
authors.lastname: Hansen
authors.forename: Alberto
authors.initials: A
authors.lastname: Briganti
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000379:methods* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D016016:Proportional Hazards Models; D018426:SEER Program; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000601:surgery*; D019459:Urothelium / Q000473:pathology*