title: Liver resection for colorectal metastases in older adults: a paired matched analysis.
abstract: OBJECTIVE
  To assess the safety and long-term results of hepatic resection of colorectal liver metastases (CLM) in older adults.
  
  
  METHODS
  Case-control.
  
  
  METHODS
  Single liver and multivisceral transplant center.
  
  
  METHODS
  Individuals with CLM: 32 aged 70 and older (older group) and 32 younger than 70 (younger group) matched in a 1:1 ratio according to sex, primary tumor site, liver metastases at diagnosis, number of metastases, maximum tumor size, infiltration of cut margin, type of hepatic resection, and hepatic resection timing.
  
  
  METHODS
  Postoperative complications and survival rates.
  
  
  RESULTS
  There was no significant difference in preoperative clinical findings between the two study groups. The incidence of cumulative postoperative complications was similar in the older (28.1%) and younger (34.4%) groups (P = .10). One-, 3-, and 5-year disease-free survival rates were 57.6%, 32.9%, and 16.4%, respectively, in the younger group and 67.9%, 29.2%, and 19.5%, respectively, in the older group (P = .72). One-, 3-, and 5-year participant survival rates were 84.1%, 51.9%, and 33.3%, respectively, in the older group and 93.6%, 63%, and 28%, respectively, in the younger group (P = .50).
  
  
  CONCLUSIONS
  Resection of colorectal liver metastases in older adults can be performed with low mortality and morbidity and offers a long-time survival advantage to many of these individuals. Based on the results of this case-control study, older adults should be considered for surgical treatment whenever possible.
authors.affiliation: Liver and Multivisceral Transplant Center, Hepatopancreatic and Biliary Surgery, University of Modena and Reggio Emilia, Modena, Italy. f.diben@virgilio.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Di Benedetto
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Berretta
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Amico
authors.forename: Roberto
authors.initials: R
authors.lastname: Montalti
authors.forename: Nicola
authors.initials: N
authors.lastname: De Ruvo
authors.forename: Nicola
authors.initials: N
authors.lastname: Cautero
authors.forename: Gian Piero
authors.initials: GP
authors.lastname: Guerrini
authors.forename: Roberto
authors.initials: R
authors.lastname: Ballarin
authors.forename: Mario
authors.initials: M
authors.lastname: Spaggiari
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tarantino
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Sandro
authors.forename: Anna
authors.initials: A
authors.lastname: Pecchi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Luppi
authors.forename: Giorgio-Enrico
authors.initials: GE
authors.lastname: Gerunda
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors