title: Plasma-enhanced copolymerization of amino acid and synthetic monomers.
abstract: In this paper we report the use of plasma-enhanced chemical vapor deposition (PECVD) for the simultaneous deposition and copolymerization of an amino acid with other organic and inorganic monomers. We investigate the fundamental effects of plasma-enhanced copolymerization on different material chemistries in stable ultrathin coatings of mixed composition with an amino acid component. This study serves to determine the feasibility of a direct, facile method for integrating biocompatible/active materials into robust polymerized coatings with the ability to plasma copolymerize a biological molecule (L-tyrosine) with different synthetic materials in a dry, one-step process to form ultrathin coatings of mixed composition. This process may lead to a method of interfacing biologic systems with synthetic materials as a way to enhance the biomaterial-tissue interface and preserve biological activity within composite films.
authors.affiliation: School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
authors.forename: Kyle D
authors.initials: KD
authors.lastname: Anderson
authors.forename: Seth L
authors.initials: SL
authors.lastname: Young
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.forename: Rachel
authors.initials: R
authors.lastname: Jakubiak
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Bunning
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Naik
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Tsukruk
mesh_terms: D000181:Acrylonitrile / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002627:Chemistry, Physical / Q000379:methods; D008689:Methacrylates / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D014443:Tyrosine / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D008689:Methacrylates; D014443:Tyrosine; C005044:hydroxyethyl methacrylate; D000181:Acrylonitrile