title: Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats.
abstract: It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children.
authors.affiliation: Dokuz Eylul University, Medical Faculty, Department of Pediatrics, Izmir, Turkey. durgul.ozdemir@deu.edu.tr
authors.forename: Durgul
authors.initials: D
authors.lastname: Ozdemir
authors.forename: Basak
authors.initials: B
authors.lastname: Baykara
authors.forename: Ilkay
authors.initials: I
authors.lastname: Aksu
authors.forename: Muge
authors.initials: M
authors.lastname: Kiray
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Sisman
authors.forename: Ferihan
authors.initials: F
authors.lastname: Cetin
authors.forename: Ayfer
authors.initials: A
authors.lastname: Dayi
authors.forename: Tugba
authors.initials: T
authors.lastname: Gurpinar
authors.forename: Nazan
authors.initials: N
authors.lastname: Uysal
authors.forename: M Nuri
authors.initials: MN
authors.lastname: Arda
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000097:blood* / Q000150:complications*; D003071:Cognition; D003072:Cognition Disorders / Q000097:blood* / Q000150:complications; D006624:Hippocampus / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013223:Statistics as Topic
chemical_list: D007334:Insulin-Like Growth Factor I