title: The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children.
abstract: A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7-13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) (P = 0.0001). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0 mmol/L, 4.5 mmol/L, 8.4 mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8 mmol/L, 4.5 mmol/L, 5.9 mU/mL, and 1.2, resp.) (P = 0.0001). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0-2.0, P = 0.0334), 1.5 (95% CI: 0.9-2.5, P = 0.0890), and 2.8 (95%CI: 1.5-5.4, P = 0.0014), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension.
authors.affiliation: National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Haiquan
authors.initials: H
authors.lastname: Xu
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Hu
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Songming
authors.initials: S
authors.lastname: Du
authors.forename: Hongyun
authors.initials: H
authors.lastname: Fang
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Tingyu
authors.initials: T
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Hongwei
authors.initials: H
authors.lastname: Guo
authors.forename: Guifa
authors.initials: G
authors.lastname: Xu
authors.forename: Ailing
authors.initials: A
authors.lastname: Liu