title: Oocyte vitrification technology has made egg-sharing donation easier in China.
abstract: When infertile women undergoing IVF or intracytoplasmic sperm injection (ICSI) have more than 20 mature oocytes retrieved, at least 15 oocytes are inseminated by their husband's spermatozoa. The extra oocytes are cryopreserved by vitrification. If the patients became pregnant and have healthy live births, the patients are encouraged to donate their remaining cryopreserved oocytes. Forty-seven egg-sharing donors were recruited after having normal deliveries and they donated their remaining oocytes, totalling 395 cryopreserved oocytes, to 75 recipients. The survival rate of vitrified-warmed oocytes was 83.0%. Following insemination by ICSI, the fertilization and cleavage rates were 83.8% and 89.8%, respectively. Out of 75 recipients, 71 recipients completed the treatment cycles and 30 of them became pregnant with clinical pregnancy and implantation rates of 42.3% and 25.5%, respectively. The birthweight of the new-born infants (22 from singleton and two from one set of twins) were 3344.5 ± 669.1g and 2425.0 ± 742.5 g, respectively. No birth defects were observed for the live births. These results indicate that oocyte vitrification is an effective methodology for an egg-sharing donation programme, with acceptable pregnancy and implantation rates.
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Ling-Bo
authors.initials: LB
authors.lastname: Cai
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Qian
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yun-Dong
authors.initials: YD
authors.lastname: Mao
authors.forename: Zheng-Jie
authors.initials: ZJ
authors.lastname: Yan
authors.forename: Cui-Zhen
authors.initials: CZ
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: De-Chun
authors.initials: DC
authors.lastname: Chai
authors.forename: Ri-Cheng
authors.initials: RC
authors.lastname: Chian
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000328:Adult; D001724:Birth Weight; D002681:China; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D018587:Oocyte Donation / Q000379:methods*; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D058989:Vitrification