title: Evolved gas analysis of Ti(C5H5)2Cl2 by means of Li+ ion attachment mass spectrometry.
abstract: Characterization of the compound Ti(C(5)H(5))(2)Cl(2) was studied using Li(+) ion attachment mass spectrometry (IAMS) as an analytical methodology. Since this target compound is used as an anticancer drug in the treatment of leukemia, accurate and rapid monitoring methods for the determination of titanium drugs in a hospital environment are desirable. A quadrupole mass spectrometry system along with a Li(+) ion attachment technique and a direct inlet probe (DIP) produced the Li(+) adduct of Ti(C(5)H(5))(2)Cl(2), Ti(C(5)H(5))(2)Cl(2)Li(+). The DIP also was used to study the temperature-resolved behavior of this compound. The slope of the plot of signal intensity of Ti(C(5)H(5))(2)Cl(2)Li(+) versus temperature for Ti(C(5)H(5))(2)Cl(2) sublimation from 60 to 100 °C was used to determine an apparent activation energy (E(a)) of 124.43 kJ/mol for the sublimation of Ti(C(5)H(5))(2)Cl(2). This value is comparable to the reported value of 118.8 kJ/mol for molar enthalpy of sublimation of Ti(C(5)H(5))(2)Cl(2). These results demonstrate that the IAMS methodology can be used to study the enthalpy of sublimation for d-metal complex materials.
authors.affiliation: Department of Chemistry, Faculty of Sciences and Engineering, Meisei University, Hodokubo 2-1-1, Hino, Tokyo 191-8506, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Suga
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kitahara
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fujii
mesh_terms: D005740:Gases / Q000032:analysis; D007477:Ions / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D013058:Mass Spectrometry; D009942:Organometallic Compounds / Q000032:analysis*; D013816:Thermodynamics
chemical_list: D005740:Gases; D007477:Ions; D009942:Organometallic Compounds; D008094:Lithium; C020528:titanocene dichloride