title: Oxidative stress due to anesthesia and surgical trauma and comparison of the effects of propofol and thiopental in dogs.
abstract: The present study aimed to evaluate the effect of propofol and thiopental on the plasma oxidant-antioxidant profile in dogs undergoing surgery at doses used to induce anesthesia. The plasma total oxidant status (TOS) and oxidative stress index (OSI) levels increased significantly with time in both groups, whereas the plasma total antioxidant status (TAS) levels decreased with time in both groups. The OSI was significantly higher at the end of surgery than before induction of anesthesia in both groups. The TOS and OSI change ratio of propofol group were significantly lower than that of thiopental group. In conclusion, our findings show that propofol has antioxidant effects in dogs. Further studies need to be conducted to demonstrate the exact mechanism of oxidative stress due to anesthesia and surgery in dogs.
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. romanavet@hanmail.net
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000662:veterinary*; D013874:Thiopental / Q000494:pharmacology*; D024505:Tocopherols / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D024505:Tocopherols; D015742:Propofol