title: Clinical features and testicular morphology in patients with Kallmann syndrome.
abstract: Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.
authors.affiliation: Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nishio
authors.forename: Kentaro
authors.initials: K
authors.lastname: Mizuno
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Moritoki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kamisawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kojima
authors.forename: Haruo
authors.initials: H
authors.lastname: Mizuno
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kohri
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000293:Adolescent; D002648:Child; D003456:Cryptorchidism / Q000601:surgery; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis; D007150:Immunohistochemistry; D017436:Kallmann Syndrome / Q000378:metabolism / Q000473:pathology*; D007985:Leydig Cells / Q000378:metabolism; D008297:Male; D013737:Testis / Q000378:metabolism / Q000473:pathology*