title: Copper-catalyzed synthesis of substituted indazoles from 2-chloroarenes at low catalyst-loading.
abstract: An efficient and convenient access to 1-substituted indazol-3-ones 2 has been achieved throughout the intramolecular C-N bond formations of 2-chloro-benzoic acid-N'-aryl and alkyl-hydrazides employing 0.5 mol% of cuprous (I) iodide and 20 mol% of L-proline as catalyst precursors under mild conditions in moderate to excellent yields.
authors.affiliation: Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Nakaku, Sakai, Osaka 599-8531, Japan. tanimori@bioinfo.osakafu-u.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanimori
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Iesaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry
chemical_list: D007191:Indazoles; D003300:Copper; D011392:Proline