title: Brain-specific interleukin-1 receptor accessory protein in sleep regulation.
abstract: Interleukin (IL)-1β is involved in several brain functions, including sleep regulation. It promotes non-rapid eye movement (NREM) sleep via the IL-1 type I receptor. IL-1β/IL-1 receptor complex signaling requires adaptor proteins, e.g., the IL-1 receptor brain-specific accessory protein (AcPb). We have cloned and characterized rat AcPb, which shares substantial homologies with mouse AcPb and, compared with AcP, is preferentially expressed in the brain. Furthermore, rat somatosensory cortex AcPb mRNA varied across the day with sleep propensity, increased after sleep deprivation, and was induced by somnogenic doses of IL-1β. Duration of NREM sleep was slightly shorter and duration of REM sleep was slightly longer in AcPb knockout than wild-type mice. In response to lipopolysaccharide, which is used to induce IL-1β, sleep responses were exaggerated in AcPb knockout mice, suggesting that, in normal mice, inflammation-mediated sleep responses are attenuated by AcPb. We conclude that AcPb has a role in sleep responses to inflammatory stimuli and, possibly, in physiological sleep regulation.
authors.affiliation: Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane, WA 99210-1495, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Taishi
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Davis
authors.forename: Omar
authors.initials: O
authors.lastname: Bayomy
authors.forename: Mark R
authors.initials: MR
authors.lastname: Zielinski
authors.forename: Fan
authors.initials: F
authors.lastname: Liao
authors.forename: James M
authors.initials: JM
authors.lastname: Clinton
authors.forename: Dirk E
authors.initials: DE
authors.lastname: Smith
authors.forename: James M
authors.initials: JM
authors.lastname: Krueger
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D053577:Interleukin-1 Receptor Accessory Protein / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D053573:Receptors, Interleukin-1 Type I / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D053577:Interleukin-1 Receptor Accessory Protein; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D053573:Receptors, Interleukin-1 Type I