title: Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient.
abstract: A 55-year-old Japanese female was diagnosed with systemic lupus erythematosus (SLE) and developed nephrotic syndrome. She was diagnosed with lupus nephritis by a percutaneous renal biopsy. She was treated with intravenous steroid pulse therapy twice, but it proved to be ineffective. She achieved a complete remission after intravenous cyclophosphamide pulse (CPAIV) therapy. Thereafter, her lupus nephritis was well controlled and demonstrated only a low activity. However, she suffered Epstein- Barr virus (EBV)-associated hemophagocytic syndrome (HPS) twice, and in each case she was treated with anticancer drugs and achieved a complete remission. This was a rare case of lupus nephritis who showed repeated EBV-associated HPS.
authors.affiliation: Department of Nephrology and Kidney Center, Iizuka Hospital, Iizuka City, Japan. smiurah2@aih-net.com
authors.forename: Shuhei
authors.initials: S
authors.lastname: Miura
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Takeda
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Muto
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mukai
authors.forename: Masahide
authors.initials: M
authors.lastname: Furusho
authors.forename: Satsuki
authors.initials: S
authors.lastname: Nakashita
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Maeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents