title: Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population.
abstract: Within the last decade the prevalence of adult patients living with congenital heart disease equals that seen in children. This expanding population poses a challenge to clinical cardiologists who will be caring for patients with the clinical manifestations of this condition. Neonatal lupus is a model of passively acquired autoimmunity and is responsible for the majority of clinical cases of congenital heart block (CHB). This review will focus on the presentation, pathophysiology, and the long-term follow-up of CHB associated with neonatal lupus, and discuss important diagnostic tests, familial implications, and pacemaker issues associated with the care of an adult with CHB.
authors.affiliation: Department of Pediatrics, Children's Hospital of Montefiore, Bronx, NY, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Capone
authors.forename: Jill P
authors.initials: JP
authors.lastname: Buyon
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Friedman
authors.forename: William H
authors.initials: WH
authors.lastname: Frishman
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D006327:Heart Block / Q000151:congenital* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000276:immunology; D010138:Pacemaker, Artificial; D010641:Phenotype; D011788:Quality of Life; D015996:Survival Rate
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G