title: Therapeutic drug monitoring in the treatment of tuberculosis patients.
abstract: At the University Centre for Chronic Diseases Dekkerswald, a tertiary tuberculosis (TB) referral hospital in The Netherlands, therapeutic drug monitoring (TDM) is used in patients in case of relapse TB, when there is delayed response to TB treatment, and when abnormal TB drug concentrations are suspected for other reasons. In this article, a case series is presented to illustrate the value of individualized TB drug dosing in four patients with low TB drug concentrations. Increased doses of the TB drugs, especially of rifampicin, resulted in adequate peak plasma concentrations and improved clinical response to treatment in these patients, while no adverse events occurred.
authors.affiliation: Radboud University Nijmegen Medical Centre, University Centre for Chronic Diseases Dekkerswald, Nijmeegsebaan 31, 6561 KE Groesbeek, The Netherlands. c.magis-escurraibanez@ulc.umcn.nl
authors.forename: Cecile
authors.initials: C
authors.lastname: Magis-Escurra
authors.forename: Jossy
authors.initials: J
authors.lastname: van den Boogaard
authors.forename: Dirk
authors.initials: D
authors.lastname: Ijdema
authors.forename: Martin
authors.initials: M
authors.lastname: Boeree
authors.forename: Rob
authors.initials: R
authors.lastname: Aarnoutse
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D000904:Antibiotics, Antitubercular / Q000097:blood / Q000493:pharmacokinetics; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D016903:Drug Monitoring / Q000379:methods*; D004977:Ethambutol / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D007538:Isoniazid / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D057285:Precision Medicine; D011718:Pyrazinamide / Q000097:blood / Q000493:pharmacokinetics; D012008:Recurrence; D012293:Rifampin / Q000097:blood / Q000493:pharmacokinetics; D012559:Schizophrenia / Q000150:complications; D013183:Sputum / Q000382:microbiology; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin