title: Quantification of glucose diffusion in human lung tissues by using Fourier domain optical coherence tomography.
abstract: In this study, we report permeability coefficients of 30% glucose diffusion by the optical coherence tomography signal slope (OCTSS) method in four kinds of human lung tissue in vitro: normal lung tissue, benign granulomatosis lung tissue, squamous cell carcinoma and adenocarcinoma tumor. To quantify the permeability coefficient of the agent, the monitored region was 80 μm thickness at a tissue depth of ca 230 μm from the surface. The permeability coefficients of 30% glucose from 10 independent experiments were averaged and found to be (1.35 ± 0.13) × 10(-5) cm s(-1) from the normal lung tissue, (1.78 ± 0.21) × 10(-5) cm s(-1) from the benign granulomatosis lung tissue, (2.88 ± 0.19) × 10(-5) cm s(-1) from the adenocarcinoma tumor and (3.53 ± 0.25) × 10(-5) cm s(-1) from the squamous cell carcinoma, respectively. It could be clearly seen that the permeability coefficients of 30% glucose increase ca 32%, 113% and 162% in the benign granulomatosis, adenocarcinoma tumor and squamous cell carcinoma of human lung tissue compared with that from the normal lung tissue, respectively. Therefore, we inferred from this pilot study that the OCT imaging is a feasible method to distinguish normal and cancer lung tissue.
authors.affiliation: MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China. xiaoxiao2009021500@live.cn
authors.forename: Xiao
authors.initials: X
authors.lastname: Guo
authors.forename: Guoyong
authors.initials: G
authors.lastname: Wu
authors.forename: Huajiang
authors.initials: H
authors.lastname: Wei
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Deng
authors.forename: Hongqin
authors.initials: H
authors.lastname: Yang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Ji
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.forename: Zhouyi
authors.initials: Z
authors.lastname: Guo
authors.forename: Shusen
authors.initials: S
authors.lastname: Xie
authors.forename: Huiqing
authors.initials: H
authors.lastname: Zhong
authors.forename: Qingliang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D004058:Diffusion; D005947:Glucose / Q000378:metabolism*; D006099:Granuloma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010539:Permeability; D010865:Pilot Projects; D041623:Tomography, Optical Coherence
chemical_list: D005947:Glucose