title: Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase.
abstract: The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β(1)-adrenergic receptors in cardiac plasma membranes.
authors.affiliation: Institute of Biomedical Research August Pi i Sunyer, Villarroel 170, E-08036 Barcelona, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Llagostera
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Álvarez López
authors.forename: Cecilia
authors.initials: C
authors.lastname: Scimia
authors.forename: Daniele
authors.initials: D
authors.lastname: Catalucci
authors.forename: Marcelina
authors.initials: M
authors.lastname: Párrizas
authors.forename: Pilar
authors.initials: P
authors.lastname: Ruiz-Lozano
authors.forename: Perla
authors.initials: P
authors.lastname: Kaliman
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D009206:Myocardium / Q000166:cytology; D009223:Myotonic Dystrophy / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D065636:Myotonin-Protein Kinase; D010766:Phosphorylation / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency*; D011943:Receptors, Adrenergic, beta / Q000097:blood / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D000318:Adrenergic beta-Agonists; C585516:DMPK protein, mouse; D011943:Receptors, Adrenergic, beta; D033921:Vesicular Transport Proteins; C093846:early endosome antigen 1; D012694:Serine; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol