title: Incidence and mortality of Parkinson's disease in older Canadians.
abstract: OBJECTIVE
  To estimate the age-specific incidence of Parkinson's disease (PD) in elderly persons in the Canadian province of British Columbia (BC). All-cause and injury mortalities and relative risk of death for those persons with PD were also examined.
  
  
  METHODS
  A historical cohort study was conducted using 5 provincial administrative databases from 1991/92 to 2000/2001. A series of algorithms based on the databases were created for case ascertainment of PD for persons 65 years or older. Crude and age-specific incidence and mortality rates were calculated using person-years of follow-up as the denominator. The impact of PD on all-cause and injury mortalities was examined using multivariate Cox regression models to provide adjusted hazard ratios.
  
  
  RESULTS
  10,910 incidence cases over 6,051,682 person-years of follow-up were identified. The crude annual incidence rate was 252 per 100,000 person-years. Over the nine year period, age standardized incidence for males ranged from 207 to 396 per 100,000 person-years and 127 to 259 per 100,000 person-years for females. Persons with PD were at a 43% greater risk of all-cause mortality and specifically, 51% greater risk of injury mortality.
  
  
  CONCLUSIONS
  Incidence of PD is substantially higher in advanced age with age adjusted increases for both all-cause and injury mortalities. These findings also highlight falls as a primary factor for injury mortality in PD.
authors.affiliation: School of Public Health, University of Alberta, Edmonton, AB, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Allyson Jones
authors.forename: W R
authors.initials: WR
authors.lastname: Wayne Martin
authors.forename: Marguerite
authors.initials: M
authors.lastname: Wieler
authors.forename: Pam
authors.initials: P
authors.lastname: King-Jesso
authors.forename: Donald C
authors.initials: DC
authors.lastname: Voaklander
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000465:Algorithms; D002170:Canada / Q000453:epidemiology; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010300:Parkinson Disease / Q000453:epidemiology* / Q000401:mortality*; D012189:Retrospective Studies; D012737:Sex Factors; D018709:Statistics, Nonparametric