title: Educational attainment and mean leukocyte telomere length in women in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study.
abstract: BACKGROUND
  Telomere length has been postulated as a marker of biological aging. Recent evidence has suggested that educational attainment but not social class is associated with telemore length.
  
  
  METHODS
  We investigated the associations between educational attainment, social class and relative mean telomere length in an ethnically homogeneous population of 4441 women, aged 41-80 years. Mean telomere length was measured using high-throughput quantitative Real Time PCR.
  
  
  RESULTS
  Educational attainment (p=0.015) but not social class (p=0.61) was associated with mean telomere length in these data. This association was independent of social class and of systolic blood pressure, high-density lipoprotein cholesterol, cigarette smoking, body mass index, glycated hemoglobin, plasma vitamin C and physical activity (p=0.014), and was not attenuated through additional adjustment for measures of social adversity, including those experienced during childhood (p=0.006).
  
  
  CONCLUSIONS
  Our results, at least for women, provide support for the findings previously reported in this journal that lower educational attainment, but not social class, is associated with shorter telomere length.
authors.affiliation: Department of Public Health and Primary Care, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK. ps404@cam.ac.uk
authors.forename: Paul G
authors.initials: PG
authors.lastname: Surtees
authors.forename: Nicholas W J
authors.initials: NW
authors.lastname: Wainwright
authors.forename: Karen A
authors.initials: KA
authors.lastname: Pooley
authors.forename: Robert N
authors.initials: RN
authors.lastname: Luben
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004522:Educational Status; D004739:England; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008875:Middle Aged; D012923:Social Class; D059506:Telomere Shortening