title: Recent advances in the application of antibodies as therapeutics.
abstract: The application of antibodies as therapeutic agents in the treatment of cancer now represents a significant proportion of the oncology drug arena. Despite this success, the ability to engineer and exploit antibodies in many different formats is ensuring that new avenues for their therapeutic application are constantly being examined. This review examines a selection of novel antibody-based therapeutic strategies that are currently in late preclinical and clinical evaluation.
authors.affiliation: Molecular Therapeutics, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
authors.forename: Roberta E
authors.initials: RE
authors.lastname: Burden
authors.forename: Jill
authors.initials: J
authors.lastname: Caswell
authors.forename: Francois
authors.initials: F
authors.lastname: Fay
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Scott
mesh_terms: D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans
chemical_list: D000906:Antibodies