title: Single-step versus two-step endo-ultrasonography-guided drainage of pancreatic pseudocyst.
abstract: OBJECTIVE
  The aim of this prospective study was to compare the feasibility, technical success rate and complication between single-step endo-ultrasonography (EUS)-guided and two-step EUS-guided drainage technique for symptomatic pancreatic pseudocyst (PP).
  
  
  METHODS
  Twenty-one PP patients with clear intra-cystic fluid that needed to be drained were divided into two groups, depending on the availability of the therapeutic echoendoscope at the time of the procedure: Group 1 (13 patients) underwent a single-step EUS-guided endoscopic drainage and Group 2 (8 patients) underwent a two-step EUS-guided drainage technique.
  
  
  RESULTS
  In Group 1 immediate technical success was achieved in 92.3% (12/13); two patients had recurrent PP and both were successfully treated by a second EUS-guided drainage. Clinical success was achieved in all cases. In Group 2 technical success was achieved in 75.0% of the patients (6/8). One patient (12.5%) bled 36 h after the procedure. Five out of 6 patients had long-term success. Clinical success was significantly greater in Group 1 (P < 0.05).
  
  
  CONCLUSIONS
  The technique of single-step EUS-guided drainage was superior to the technique of a two-step EUS-guided drainage technique for PP drainage.
authors.affiliation: Division of Gastrointestinal Endoscopy, San Paolo University Hospital, Milan, Italy.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Mangiavillano
authors.forename: Paolo Giorgio
authors.initials: PG
authors.lastname: Arcidiacono
authors.forename: Enzo
authors.initials: E
authors.lastname: Masci
authors.forename: Alberto
authors.initials: A
authors.lastname: Mariani
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Petrone
authors.forename: Silvia
authors.initials: S
authors.lastname: Carrara
authors.forename: Sabrina
authors.initials: S
authors.lastname: Testoni
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Testoni
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D004322:Drainage / Q000295:instrumentation / Q000379:methods*; D019160:Endosonography / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005774:Gastrostomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010192:Pancreatic Pseudocyst / Q000000981:diagnostic imaging* / Q000601:surgery / Q000628:therapy*; D050500:Pancreatitis, Chronic / Q000150:complications; D011446:Prospective Studies; D015607:Stents / Q000592:standards*; D016896:Treatment Outcome