title: Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins.
abstract: The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.
authors.affiliation: Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.
authors.forename: Xiangxin
authors.initials: X
authors.lastname: Meng
authors.forename: Dachuan
authors.initials: D
authors.lastname: Yang
authors.forename: Golshid
authors.initials: G
authors.lastname: Keyvan
authors.forename: Bozena
authors.initials: B
authors.lastname: Michniak-Kohn
authors.forename: Somenath
authors.initials: S
authors.lastname: Mitra
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006118:Griseofulvin / Q000138:chemical synthesis* / Q000737:chemistry*; D008027:Light; D008832:Microchemistry / Q000379:methods*; D008956:Models, Chemical; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012542:Scattering, Radiation; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013501:Surface-Active Agents / Q000737:chemistry; D013535:Suspensions; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D011108:Polymers; D012996:Solutions; D013501:Surface-Active Agents; D013535:Suspensions; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D006118:Griseofulvin