title: A new 'Linc' between noncoding RNAs and blood development.
abstract: Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.
authors.affiliation: Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Vikram R
authors.initials: VR
authors.lastname: Paralkar
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Weiss
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D041905:Erythroid Cells / Q000166:cytology*; D004920:Erythropoiesis / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D022661:RNA, Untranslated / Q000378:metabolism*
chemical_list: D022661:RNA, Untranslated