title: Serum and saliva levels of cathepsin L in patients with acute coronary syndrome.
abstract: OBJECTIVE
  Coronary artery disease (CAD) is the major cause of death nearly all over the world, and accurate and rapid diagnosis of CAD is of major medical and economic importance. The aim of this study was to evaluate the serum and saliva levels of cathepsin L in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  In a cross-sectional study, 39 patients with ACS and 28 with controls were recruited to the study, and cathepsin L levels were measured in serum, resting saliva, and stimulated saliva obtained 12 and 24 h after the onset of ACS by ELISA method. Statistical analyses of Fisher's exact test, the Student's t-test or Kruskal-Wallis test were performed.
  
  
  RESULTS
  Stimulated saliva cathepsin L levels in patients with ACS 12 hours but not 24 hours after admission showed significant decrease compared with that in control subjects. However, there were no significant differences in serum and unstimulated saliva cathepsin L levels between groups.
  
  
  CONCLUSIONS
  Serum and saliva levels of cathepsin L remain unchanged in patients with ACS and hence may not be a promising factor in CAD risk assessment.
  
  
  CONCLUSIONS
  It seems that serum and saliva cathepsin L may not be a good biomarker for CHD.
  
  
  BACKGROUND
  CAD: Coronary artery disease, ACS: Acute coronary syndrome, CHD: Coronary heart disease, EU: Emergency unit, MI: Myocardial infarction.
  
  
  BACKGROUND
  Cathepsin L, Acute coronary syndrome, Resting saliva, Stimulated saliva. How to cite this article: Mirzaii-Dizgah I, Riahi E. Serum and Saliva Levels of Cathepsin L in Patients with Acute Coronary Syndrome. J Contemp Dent Pract 2011;12(2):114-119.
authors.affiliation: Department of PhysiologyAJA University of Medical Sciences, Tehran, Iran. emirzaii@razi.tums.ac.ir
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.forename: Esmail
authors.initials: E
authors.lastname: Riahi
mesh_terms: D054058:Acute Coronary Syndrome / Q000201:enzymology*; D015415:Biomarkers; D016022:Case-Control Studies; D056668:Cathepsin L / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D006801:Humans; D010812:Physical Stimulation; D012463:Saliva / Q000737:chemistry; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D056668:Cathepsin L