title: Impact of a single endometrial injury on assisted reproductive technology outcome: a preliminary observational study.
abstract: OBJECTIVE
  To find a more acceptable strategy for our patients to improve endometrial receptivity in assisted reproductive technologies (ART) and to study the impact of a single endometrial sampling performed on day 21 of the spontaneous menstrual cycle.
  
  
  METHODS
  In this preliminary study, the possible beneficial effects on ART outcome of a single biopsy performed on the midluteal phase (day 21) of the spontaneous menstrual cycle preceding controlled ovarian stimulation was tested in a group of patients with 3 or more implantation failures.
  
  
  RESULTS
  After endometrial biopsy 45.94% of patients with more than two failed ART cycles obtained clinical pregnancy.
  
  
  CONCLUSIONS
  Although these preliminary results are encouraging, further investigation is needed to validate the study.
authors.affiliation: Section of Reproductive Sciences, Department of Medicine and Sciences of the Aging, Faculty of Medicine and Surgery, University "G. d'Annunzio," Chieti-Pescara, Italy. tiboni@unich.it
authors.forename: Gian Mario
authors.initials: GM
authors.lastname: Tiboni
authors.forename: Franca
authors.initials: F
authors.lastname: Giampietro
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gabriele
authors.forename: Valeria
authors.initials: V
authors.lastname: Di Donato
authors.forename: Gianna Gabriella
authors.initials: GG
authors.lastname: Impicciatore
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D004717:Endometrium / Q000502:physiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female; D008297:Male; D008597:Menstrual Cycle; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted