title: Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study.
abstract: We aimed to assess the safety and efficacy of high-dose intermittent vitamin D supplementation in adolescents. Twenty-two healthy adolescents with serum 25 hydroxy-vitamin D (25-OHD) of 12.5-50 nmol/l were randomised to receive 300,000 IU or 150,000 IU of vitamin D3, or placebo orally 6-monthly for 1 year. At 12 months, the average vitamin D levels for the 300,000 IU, 150,000 IU and placebo groups were 63.0, 41.1 and 35.8 nmol/l, respectively, (P=0.004 for difference between 300 000 IU group and placebo after adjustment for age, sex and seasonal variation). At 12 months, one participant receiving 300,000 IU was mildly deficient (25-OHD 49 nmol/l), whereas five out of six (83%) in the placebo and four out of seven participants (57%) in the 150,000 IU group remained deficient. There were no adverse events. Compliance was high. This suggests that 300,000 IU vitamin D3 orally 6-monthly may safely and effectively correct vitamin D deficiency in adolescents.
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Carnes
authors.forename: S
authors.initials: S
authors.lastname: Quinn
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: G
authors.initials: G
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Winzenberg
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002762:Cholecalciferol / Q000008:administration & dosage / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance; D010865:Pilot Projects; D012621:Seasons; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy; D014815:Vitamins / Q000008:administration & dosage* / Q000097:blood
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol