title: Bone metastases from gynaecological epithelial cancers.
abstract: The aim of this study was to investigate the clinical features and prognosis in patients with gynaecological epithelial cancers metastasised to bones. A total of 26 patients were studied retrospectively. Clinical and pathological data were analysed along with a follow-up. It was found that the interval from primary diagnosis of cancer until bony relapse varied between 0 and 163 months (31.4 ± 36.8). Bone metastases were solitary in 11 cases and multifocal in 15 cases. A total of 14 patients demonstrated only bony metastases while 12 had both bony and non-bony metastases. The time to follow-up from the diagnosis of osseous relapse varied between 1 and 43 months (10.0 ± 10.4). During follow-ups, 13 patients died and 13 patients survived. In both univariate and multivariate analyses, synchronous non-bony metastases and symptomatic treatment without oncological therapy impaired prognosis. It was concluded that even in the presence of multiple bone metastases, some patients may benefit from radiotherapy, chemotherapy or a combination of both, rather than palliative care alone, providing they do not have additional soft tissue metastases.
authors.affiliation: Palliative Care Unit, Department of Palliative Medicine, Chair of Oncology, Medical University of Lodz, ul. Ciolkowskiego 2, 93-509 Lodz, Poland. lgottwald@wp.pl
authors.forename: L
authors.initials: L
authors.lastname: Gottwald
authors.forename: A
authors.initials: A
authors.lastname: Dukowicz
authors.forename: J
authors.initials: J
authors.lastname: Piekarski
authors.forename: B
authors.initials: B
authors.lastname: Misiewicz
authors.forename: M
authors.initials: M
authors.lastname: Spych
authors.forename: P
authors.initials: P
authors.lastname: Misiewicz
authors.forename: S
authors.initials: S
authors.lastname: Kazmierczak-Lukaszewicz
authors.forename: M
authors.initials: M
authors.lastname: Moszynska-Zielinska
authors.forename: A
authors.initials: A
authors.lastname: Cialkowska-Rysz
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary*; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary*; D005260:Female; D005833:Genital Neoplasms, Female / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies