title: [Significance of MUM-1/IRF4 protein expression in follicular lymphoma].
abstract: OBJECTIVE
  To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma.
  
  
  METHODS
  Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CD10, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry.
  
  
  RESULTS
  Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 (≥ 25%) were 39.8% (39/98), 62.2% (61/98), 80.6% (79/98), 87.8% (86/98) and 50.0% (49/98), respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade (r = 0.628, P = 0.000) and Ki-67 index (r = 0.473, P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597, P = 0.000), but no correlation with bcl-6 and bcl-2 expression.
  
  
  CONCLUSIONS
  MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.
authors.affiliation: Department of Pathology, Shandong University School of Medicine, Jinan, China.
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Huo
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.forename: Bing-xin
authors.initials: BX
authors.lastname: Guan
authors.forename: Ai-ju
authors.initials: AJ
authors.lastname: Fang
authors.forename: Bao-cun
authors.initials: BC
authors.lastname: Sun
authors.forename: Geng-yin
authors.initials: GY
authors.lastname: Zhou
authors.forename: Kai
authors.initials: K
authors.lastname: Fu
authors.forename: Bin
authors.initials: B
authors.lastname: Meng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D008224:Lymphoma, Follicular / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015260:Neprilysin / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6; D000099218:Interferon Regulatory Factor-4
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D019394:Ki-67 Antigen; D015260:Neprilysin; D019253:Proto-Oncogene Proteins c-bcl-2; D051560:Proto-Oncogene Proteins c-bcl-6; D000099218:Interferon Regulatory Factor-4; C084103:BCL6 protein, human