title: Novel aspect of chemophototherapy in treatment of cancer.
abstract: The present review deals with the genetic implications of reactive oxygen species (ROS) to enhance horizons of chemophototherapy toward novel approaches for the treatment of various cancers. ROS are species of oxygen which are in a more reactive state than molecular oxygen. ROS play essential roles in vivo such as redox regulation, gene expression, immune response and many other cellular events. ROS generated by anticancer drugs during chemophototherapy may be associated with the activation of signal molecules like PKC, transcription factor NF-kappaB as well as destabilization of mitochondrial membrane inducing the release of apoptosis inducing agents like cytochrome c, resulting in toxicity to cancer cells. Thus, we suggest that anticancer drugs on exposure to light may generate oxidative stress following Fenton-like reaction generating hydroxyl radical. This may get on specific cell cycle receptors which may lead to cell cycle arrest and subsequently cytotoxic death of cancer cells.
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP 202002, India.
authors.forename: Sandesh
authors.initials: S
authors.lastname: Chibber
authors.forename: Mohd
authors.initials: M
authors.lastname: Farhan
authors.forename: Iftekhar
authors.initials: I
authors.lastname: Hassan
authors.forename: Imrana
authors.initials: I
authors.lastname: Naseem
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D004357:Drug Synergism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species