title: Evoked corticospinal output to the human scalene muscles is altered by lung volume.
abstract: Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC+∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC+∼40% IC) in both inspiratory and expiratory manoeuvres (p<0.001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p=0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans.
authors.affiliation: Neuroscience Research Australia, and University of New South Wales, Sydney, Australia.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Hudson
authors.forename: Janet L
authors.initials: JL
authors.lastname: Taylor
authors.forename: Ashima
authors.initials: A
authors.lastname: Anand
authors.forename: Simon C
authors.initials: SC
authors.lastname: Gandevia
authors.forename: Jane E
authors.initials: JE
authors.lastname: Butler
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D011712:Pyramidal Tracts / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000502:physiology; D013990:Tidal Volume; D014109:Total Lung Capacity; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult