title: Study on monomer suitability toward the template in molecularly imprinted polymer: an ab initio approach.
abstract: Study of monomer-template interactions in molecularly imprinted polymer (MIP) is inevitable to comprehend best selectivity at the molecular level in pre-polymer solution. In the present work, binding energies of tryptophan, an amino acid template, complexed with different monomers were computed using second order Moller Plesset theory (MP2) at 6-311++g** level in gas phase. This helped in recommending a generic MIP, suitable for the selective and sensitive diagnosis of tryptophan, in clinical setting as disease biomarker, at primitive level. The tryptophan is an important biomarker owing to its highly regulated physiological process in the treatment of premenstrual dysphoric disorder and pellagra like diseases. Frequency calculations were performed using Density Functional Theory (DFT) at B3LYP employing 6-31+g (2d, 2p) level including thermal and entropy corrections. The monomer, p-nitrophenyl acrylate (2 mol), was adjudged having giving best binding score for the complexation at ground state with tryptophan (1 mol) for MIP development.
authors.affiliation: Analytical Division, Department of Chemistry, Banaras Hindu University, Varanasi, India. prof.bbpd@yahoo.com
authors.forename: Bhim Bali
authors.initials: BB
authors.lastname: Prasad
authors.forename: Garima
authors.initials: G
authors.lastname: Rai
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D003201:Computers; D008956:Models, Chemical; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D012984:Software; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D014364:Tryptophan / Q000737:chemistry; D014732:Vibration
chemical_list: D000180:Acrylic Resins; D011108:Polymers; D014364:Tryptophan