title: [Enteropathy-associated intestinal t-cell lymphoma without celiac disease].
abstract: Type II enteropathy-associated T-cell lymphoma (EATL) is an uncommon intestinal lymphoma. We report the case of a 73-year-old man with diarrhea and weight loss. Duodenal biopsy showed atrophy and infiltration of irregular lymphocytes. Immunohistochemistry was positive for CD3, CD8, and CD56 with monoclonal TCR rearrangement. The HLA-DQ genotype was DQ5/DQ9. The Epstein-Barr virus RNA test was negative. Before specific chemotherapy could be administered, the patient was admitted to hospital for a respiratory infection and died from a cause unrelated to his lymphoma. The differential diagnosis of CD56-positive lymphoproliferative processes include type II EATL, primary T-cell/natural killer-cell intestinal lymphoma and hepatosplenic T-cell lymphoma. The patient had CD8 y CD56+ markers that allowed type I EATL to be excluded. The HLA-DQ genotype did not correspond to celiac disease and the biopsy showed proliferation of lymphocytes with atypia. The primary intestinal T-cell/natural killer-cell lymphoma was characterized mainly by the absence of CD8 and monoclonal reassortment of the TCR present in this case.
authors.affiliation: Servicio de Aparato Digestivo, Complejo Asistencial Aniversitario de León, León, España. luisvaqueroayala@gmail.com
authors.forename: Luis
authors.initials: L
authors.lastname: Vaquero
authors.forename: María G
authors.initials: MG
authors.lastname: Alvarado
authors.forename: Laura
authors.initials: L
authors.lastname: Arias
authors.forename: Sara
authors.initials: S
authors.lastname: Calleja
authors.forename: Mercedes
authors.initials: M
authors.lastname: Hernando
authors.forename: Cristina
authors.initials: C
authors.lastname: Diez-Tascón
authors.forename: Santiago
authors.initials: S
authors.lastname: Vivas
mesh_terms: D000368:Aged; D002446:Celiac Disease; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000175:diagnosis*; D006801:Humans; D008297:Male