title: Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome.
abstract: Associations between secondary focal segmental glomerulosclerosis and both obesity and obstructive sleep apnea have been previously described. Current theory suggests obesity induces glomerular hyperfiltration, leading to glomerulosclerosis. We describe a case of focal segmental glomerulosclerosis in the setting of severe obesity and obstructive sleep apnea with complete resolution of heavy proteinuria following treatment with bi-level positive airway pressure. The patient's proteinuria resolved completely with treatment of obstructive sleep apnea although the patient remained morbidly obese.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA. isaac.hall@yale.edu
authors.forename: Isaac E
authors.initials: IE
authors.lastname: Hall
authors.forename: Michael
authors.initials: M
authors.lastname: Kashgarian
authors.forename: Gilbert W
authors.initials: GW
authors.lastname: Moeckel
authors.forename: Neera K
authors.initials: NK
authors.lastname: Dahl
mesh_terms: D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010845:Obesity Hypoventilation Syndrome / Q000628:therapy*; D009767:Obesity, Morbid / Q000150:complications; D011175:Positive-Pressure Respiration / Q000379:methods*; D011507:Proteinuria / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome