title: Recurrent pericarditis after chemotherapy for acute myeloid leukemia: a case report and a modern approach to chemotherapy-induced pericarditis.
abstract: Chemotherapy-induced pericarditis has been reported in a limited number of case series. Furthermore, the management of acute pericarditis associated with chemotherapy is not standardized. In a few case reports, pericarditis associated with chemotherapy has been treated with pericardiocentesis or anti-inflammatory drugs such as steroid or nonsteroidal anti-inflammatory drugs. Recently, colchicine was introduced as an effective tool in order to manage idiopathic recurrent pericarditis. However, the effectiveness of colchicine in chemotherapy-induced pericarditis has never been reported. We report a case of recurrent pericarditis associated with chemotherapy, which was successfully treated with colchicine and ibuprofen. We maintained colchicine when the patient required repeated chemotherapy for relapsed leukemia. And the concomitant use of colchicine prevented the patient from the full development of acute pericarditis. Colchicine may be effective in the treatment and prevention not only of idiopathic recurrent pericarditis but also of acute pericarditis associated with chemotherapy as in this case.
authors.affiliation: Cardiac and Vascular Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Ga Yeon
authors.initials: GY
authors.lastname: Lee
authors.forename: Kye Taek
authors.initials: KT
authors.lastname: Ahn
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Jung
authors.forename: Sung-A
authors.initials: SA
authors.lastname: Chang
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003078:Colchicine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D010493:Pericarditis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D012008:Recurrence; D016879:Salvage Therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003078:Colchicine; D007052:Ibuprofen