title: [Impaired glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome].
abstract: OBJECTIVE
  To investigate the prevalence of impaired glucose-insulin metabolism in obstructive sleep apnea hypopnea syndrome (OSAHS); to examine the relation between severity of OSAHS and impaired glucose metabolism; and to evaluate the effectiveness of continuous positive airway pressure (CPAP) on impaired glucose metabolism.
  
  
  METHODS
  A total of 214 patients who were free of diabetes at baseline underwent both nocturnal polysomnography (PSG), and 2-h oral glucose-tolerance test, insulin and hemoglobin A1c test. CPAP treatment for glucose-insulin metabolism (+) was given to OSAHS group after informed consent had been obtained.
  
  
  RESULTS
  Eighty-eight patients and 17 patients with impaired glucose-insulin metabolism were found in OSAHS group and the control group respectively. Impaired glucose-insulin metabolism was present in 54.3% of OSAHS group and 32.7% of control group. Logistic regression analysis showed a significant positive correlation with OSAHS (AHI ≥ 10 times/h) and impaired glucose-insulin metabolism in all patients (OR = 2.440, 95%CI 1.201 - 4.958). Plasma glucose level changes had no significant differences between before and after CPAP treatment (P > 0.05).
  
  
  CONCLUSIONS
  OSAHS is associated with a high frequency of impaired glucose metabolism. The relationship between OSAHS and impaired glucose metabolism is independent of obesity. Longest apnea time (LAT) and AHI are important contributors to impaired glucose metabolism in OSAHS patients. Short-term CPAP therapy has no significant improvement on glucose metabolism in patients with OSAHS.
authors.affiliation: Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Meng
authors.forename: Xi-Heng
authors.initials: XH
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D005947:Glucose / Q000378:metabolism*; D044882:Glucose Metabolism Disorders / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000378:metabolism* / Q000628:therapy
chemical_list: D005947:Glucose