title: Growth factors and chondrogenic differentiation of mesenchymal stem cells.
abstract: The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the life quality of the affected individuals of both sexes in all age groups. Mature hyaline cartilage has a very low self-repair potential due to intrinsic properties - lack of innervation and vascular supply. Another limiting factor is low mitotic potential of chondrocytes. Small defects are healed by migration of chondrocytes, while large ones are healed by formation of inferior fibrocartilage. However, in many cases osteoarthritis develops. Recently, cellular therapy combining mesenchymal stem cells and proper differentiation factors seems to be promising tool for hyaline cartilage defects healing.
authors.affiliation: Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia. lubos.danisovic@fmed.uniba.sk
authors.forename: L
authors.initials: L
authors.lastname: Danišovič
authors.forename: I
authors.initials: I
authors.lastname: Varga
authors.forename: S
authors.initials: S
authors.lastname: Polák
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D020219:Chondrogenesis; D005346:Fibroblast Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051457:Hyaline Cartilage / Q000473:pathology / Q000637:transplantation; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000627:therapeutic use; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D010003:Osteoarthritis / Q000473:pathology / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I