title: The effects of acute alcohol consumption and eccentric muscle damage on neuromuscular function.
abstract: Voluntary and electrically stimulated muscular performance was examined to identify the effects of acute alcohol consumption on neuromuscular function in the presence and absence of exercise-induced muscle damage (EIMD). After initial neuromuscular performance measures were made, 12 subjects completed a bout of eccentric exercise (EX) using the quadriceps muscles of 1 leg while the remaining 11 subjects did not exercise (NX). Subjects then consumed either an alcoholic beverage containing 1 g·kg(-1) body weight (ALC) or a nonalcoholic beverage (OJ). On another occasion the contralateral leg of both groups was tested and those in the EX group performed an equivalent bout of eccentric exercise after which the other beverage was consumed. Measurements of neuromuscular function were made pre-exercise and 36 and 60 h post-beverage consumption. Creatine kinase (CK) was measured pre-exercise and at 12, 36, and 60 h. Significantly greater (p < 0.01) decrements in maximal voluntary isometric contraction were observed with EX ALC at 36 and 60 h compared with EX OJ, and no change was seen in the NX group. Significant decreases in voluntary activation were observed at 36 h (p = 0.003) and 60 h (p = 0.01) with EX ALC only. Elevations in CK were observed at all posteccentric exercise time points (all p < 0.05) under both EX OJ and ALC. No change in electromyography or low-frequency fatigue was observed under either treatment in either group. These results suggest that decreased neural drive appears to contribute to alcohol's effect on the magnitude of EIMD-related decrements in voluntary force generation.
authors.affiliation: School of Sport and Exercise, Massey University, Palmerston North, New Zealand. M.Barnes@massey.ac.nz
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Barnes
authors.forename: Toby
authors.initials: T
authors.lastname: Mündel
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Stannard
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D000434:Alcoholic Beverages / Q000009:adverse effects*; D000704:Analysis of Variance; D003402:Creatine Kinase / Q000097:blood; D004558:Electric Stimulation; D004576:Electromyography; D006801:Humans; D007537:Isometric Contraction; D016014:Linear Models; D008297:Male; D053580:Muscle Strength; D009469:Neuromuscular Junction / Q000201:enzymology / Q000503:physiopathology*; D009520:New Zealand; D052097:Quadriceps Muscle / Q000201:enzymology / Q000294:innervation*; D055070:Resistance Training; D013997:Time Factors; D055815:Young Adult
chemical_list: D003402:Creatine Kinase