title: [The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy].
abstract: Mucositis is one of the most frequent side effects induced by chemotherapy that damages the patients' QOL and response rate. The efficacy of Rebamipide and Polaprezinc mouthwash and uptake was evaluated. Nine patients who underwent chemotherapy and had some complaints related with mucositis were included as subjects. Rebamipide (300 mg) and Polaprezinc (150 mg) mouthwashing and uptake were performed by the subjects 4 times per day. Macroscopic examination and symptom research were performed until three months after beginning this medication. Macroscopic mucositis was shown in 5 patients previously and 4 patients improved. Seven patients had symptomatic improvement(p=0. 018). Rebamipide and Polaprezinc mouthwash and uptake is effective for patients who have mucositis induced by chemotherapy.
authors.affiliation: Dept. of Surgery, Fujiidera City Hospital.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Fukuhara
authors.forename: Masanobu
authors.initials: M
authors.lastname: Terakura
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Katsuragi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kodama
authors.forename: Yumiyo
authors.initials: Y
authors.lastname: Morisya
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hayaishi
authors.forename: Chie
authors.initials: C
authors.lastname: Nakanishi
mesh_terms: D000368:Aged; D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D052016:Mucositis / Q000139:chemically induced / Q000188:drug therapy*; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011788:Quality of Life; D015363:Quinolones / Q000627:therapeutic use*; D014944:World Health Organization; D017967:Zinc Compounds / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009067:Mouthwashes; D009942:Organometallic Compounds; D015363:Quinolones; D017967:Zinc Compounds; C061957:polaprezinc; D002336:Carnosine; C052785:rebamipide; D000409:Alanine