title: Cardiac surgery for carcinoid heart disease in 12 cases.
abstract: OBJECTIVE
  Cardiac involvement is now a major source of morbidity and mortality in patients with carcinoid tumors. We reviewed patients with carcinoid heart disease who underwent valvular surgery in our center.
  
  
  METHODS
  Twelve patients with carcinoid heart diseases underwent cardiac surgery between 2000 and 2008. Patients were divided into two groups: group A (n = 6) comprised patients who survived more than 6 months after cardiac surgery, and group D (n = 6) comprised those who died within 6 months. Preoperative factors were compared between the groups.
  
  
  RESULTS
  All the 12 patients with carcinoid heart disease underwent tricuspid valve surgery (3 had tricuspid repair and 9 had tricuspid replacement with a bioprosthetic valve). Postoperative 30-day mortality was 16.7% and 2-year actuarial survival was 50.0%. Median survival after the first diagnosis of carcinoid disease was 4.4 years that from first diagnosis of carcinoid heart disease was 2.7 years. Preoperative median left ventricular ejection fraction in group D (52.5%) was significantly lower than that in group A (67.2%, P < 0.05). There were no statistically significant differences between the groups in other parameters.
  
  
  CONCLUSIONS
  Postoperative prognosis may be worse when preoperative left ventricular ejection fraction is borderline, even if it is within the normal limits. Cardiac evaluation is needed in all patients with carcinoid disease from the earliest time of medical and oncological therapy to improve patient outcome.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. satsuki@dhzb.de
authors.forename: Satsuki
authors.initials: S
authors.lastname: Komoda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Komoda
authors.forename: Marianne E
authors.initials: ME
authors.lastname: Pavel
authors.forename: Lars
authors.initials: L
authors.lastname: Morawietz
authors.forename: Bertram
authors.initials: B
authors.lastname: Wiedenmann
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Hans B
authors.initials: HB
authors.lastname: Lehmkuhl
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D002275:Carcinoid Heart Disease / Q000401:mortality / Q000601:surgery*; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013318:Stroke Volume; D014261:Tricuspid Valve / Q000601:surgery*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology