title: Organ transplantation from a donor colonized with a multidrug-resistant organism: a case report.
abstract: The number of intensive care unit patients with infections caused by multidrug-resistant organisms is increasing in most developed countries. We report the case of a deceased multiorgan donor, who was an asymptomatic carrier of carbapenem-resistant Klebsiella pneumoniae (CR-KP) in the respiratory tract, a condition that was not diagnosed before organ harvesting and transplantation. The outcome of the 2 kidney recipients, the liver recipient, and 1 of the lung recipients was uneventful; in particular, no evidence of infection transmission or adverse graft outcomes was noted. The other lung recipient had a complicated postoperative course and, 4 weeks post transplantation, he developed a bacteremic pneumonia with CR-KP from which he subsequently died. These results suggest that, in well defined conditions, organs from donors who are CR-KP positive may be considered for transplantation.
authors.affiliation: Unit of Infectious Diseases, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Goldberg
authors.forename: J
authors.initials: J
authors.lastname: Bishara
authors.forename: S
authors.initials: S
authors.lastname: Lev
authors.forename: P
authors.initials: P
authors.lastname: Singer
authors.forename: J
authors.initials: J
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D016470:Bacteremia / Q000382:microbiology*; D015780:Carbapenems / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D017809:Fatal Outcome; D006801:Humans; D016030:Kidney Transplantation; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D016031:Liver Transplantation; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting; D055815:Young Adult
chemical_list: D015780:Carbapenems