title: Transetherification-mediated E-ring opening and stereoselective "Red-Ox" modification of furostan.
abstract: We have developed a novel E-ring opening method for furostan, and applied it to prepare D-ring modified steroids, which can be used to synthesize cephalostatin analogs.
authors.affiliation: The Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, United States.
authors.forename: Young
authors.initials: Y
authors.lastname: Cheun
authors.forename: Myong Chul
authors.initials: MC
authors.lastname: Koag
authors.forename: Yi
authors.initials: Y
authors.lastname: Kou
authors.forename: Zachary
authors.initials: Z
authors.lastname: Warnken
authors.forename: Seongmin
authors.initials: S
authors.lastname: Lee
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D018360:Crystallography, X-Ray; D004988:Ethers, Cyclic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008752:Methylene Chloride / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004988:Ethers, Cyclic; D010619:Phenazines; D013141:Spiro Compounds; D013256:Steroids; C454806:cephalostatin I; D008752:Methylene Chloride