title: Suramin ameliorates collagen induced arthritis.
abstract: Suramin, a polysulfonated polyaromatic symmetrical urea is known for multiple therapeutic effects including antineoplastic activity. It is known as an antagonist of ATP at P2X purinergic receptors. Suramin is also found to inhibit protein synthesis affecting both initiation and elongation of the polypeptide chain. As a growth factor blocker, it is reported to suppress experimental myocardial inflammation. Here, we describe the anti-arthritic property of suramin in the collagen induced arthritic (CIA) rat, a model of human rheumatoid arthritis (RA). Intraperitoneal (i.p) injection of suramin (10 mg/kg/day) for 3 weeks was found to reduce inflammation and repair joint destruction in CIA rats. Recovery of body weight (p<0.0001), reduction in splenic (p<0.05) and arthritic indices (p<0.0001) and reappearance of smooth synovial lining after suramin treatment to CIA rats were found to be significant. Levels of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 in plasma and joint extracts were reduced (p<0.0001) significantly in response to suramin treatment. Several acute phase proteins were normalized after suramin administration.
authors.affiliation: Genomics and Molecular Medicine, Institute of Genomics and Integrative Biology (CSIR), Mall Road, Delhi-110 007, India. devashish_2583@yahoo.co.in
authors.forename: Debasis
authors.initials: D
authors.lastname: Sahu
authors.forename: Ashish
authors.initials: A
authors.lastname: Saroha
authors.forename: Saugata
authors.initials: S
authors.lastname: Roy
authors.forename: Sandip
authors.initials: S
authors.lastname: Das
authors.forename: Prem S
authors.initials: PS
authors.lastname: Srivastava
authors.forename: Hasi R
authors.initials: HR
authors.lastname: Das
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D007596:Joints / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013498:Suramin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000209:Acute-Phase Proteins; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D013498:Suramin