title: Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing.
authors.forename: Jan G
authors.initials: JG
authors.lastname: Hengstler
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Marchan
authors.forename: Marcel
authors.initials: M
authors.lastname: Leist
mesh_terms: D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D004334:Drug Administration Schedule; D064420:Drug-Related Side Effects and Adverse Reactions; D005062:European Union; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D002251:Carbon Tetrachloride