title: Partially coherent lensfree tomographic microscopy [Invited].
abstract: Optical sectioning of biological specimens provides detailed volumetric information regarding their internal structure. To provide a complementary approach to existing three-dimensional (3D) microscopy modalities, we have recently demonstrated lensfree optical tomography that offers high-throughput imaging within a compact and simple platform. In this approach, in-line holograms of objects at different angles of partially coherent illumination are recorded using a digital sensor-array, which enables computing pixel super-resolved tomographic images of the specimen. This imaging modality, which forms the focus of this review, offers micrometer-scale 3D resolution over large imaging volumes of, for example, 10-15 mm(3), and can be assembled in light weight and compact architectures. Therefore, lensfree optical tomography might be particularly useful for lab-on-a-chip applications as well as for microscopy needs in resource-limited settings.
authors.affiliation: Electrical Engineering Department, University of California, Los Angeles, California 90095, USA.
authors.forename: Serhan O
authors.initials: SO
authors.lastname: Isikman
authors.forename: Waheb
authors.initials: W
authors.lastname: Bishara
authors.forename: Aydogan
authors.initials: A
authors.lastname: Ozcan
mesh_terms: D000465:Algorithms; D006696:Holography / Q000295:instrumentation* / Q000379:methods; D007091:Image Processing, Computer-Assisted; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods