title: Predictive value of MRI in the localization, staging, volume estimation, assessment of aggressiveness, and guidance of radiotherapy and biopsies in prostate cancer.
abstract: Multiparametric magnetic resonance imaging (MRI) has the potential of being the ideal prostate cancer (PCa) assessment tool. Information gathered with multiparametric MRI can serve therapy choice, guidance of interventions, and treatments. The purpose of this review is to discuss the potential role of multiparametric MRI in focal therapy with respect to patient selection and directing (robot-guided) biopsies and intensity-modulated radiation therapy (IMRT). Multiparametric MRI is a versatile and promising technique. It appears to be the best available imaging technique at the moment in localizing, staging (primary as well as recurrent disease, and local as well as distant disease), determining aggressiveness, and volume of PCa. However, larger study populations in multicenter settings have to confirm these promising results. However, before such studies can be performed more research is needed in order to achieve standardized imaging protocols.
authors.affiliation: Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. D.Yakar@rad.umcn.nl
authors.forename: Derya
authors.initials: D
authors.lastname: Yakar
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Debats
authors.forename: Joyce G R
authors.initials: JG
authors.lastname: Bomers
authors.forename: Martijn G
authors.initials: MG
authors.lastname: Schouten
authors.forename: Pieter C
authors.initials: PC
authors.lastname: Vos
authors.forename: Emile
authors.initials: E
authors.lastname: van Lin
authors.forename: Jurgen J
authors.initials: JJ
authors.lastname: Fütterer
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001706:Biopsy / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D011878:Radiotherapy / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D012008:Recurrence