title: Comparison of office-based versus home Web-based clinical assessments for Parkinson's disease.
abstract: BACKGROUND
  The feasibility and validity of Web-based assessments in Parkinson's disease is unknown. The objectives of this study were to develop and to compare home Web-based assessments with office-based assessments.
  
  
  METHODS
  We tested feasibility and validity using a longitudinal, randomized crossover design. Patients were assessed at baseline and after 6 and 12 weeks using both assessments including the Unified Parkinson's Disease Rating Scale, the Unified Dyskinesia Rating scale, timed tests, and quality-of life and Non-Motor Symptoms questionnaires.
  
  
  RESULTS
  Forty-two patients were included (22 men, 20 women; mean age, 64.7 ± 9.0 years). Only 2 patients (5%) dropped out. The mean intraclass correlation coefficient between Web- and office-based assessments ranged from 0.67 (first visit) to 0.75 (last visit) and 0.81 and 0.82 for doctor- and patient-administered scales, respectively. No differences in responsiveness (P = 0.63), and data precision (P = 0.11) were found, but Web-based assessments had fewer missing values (P = 0.01).
  
  
  CONCLUSIONS
  Web-based assessments offer a feasible format for assessing PD-related impairment from home.
authors.affiliation: Neurology Department, Complejo Asistencial Universitario Burgos, Burgos, Spain. esthercubo@gmail.com
authors.forename: Esther
authors.initials: E
authors.lastname: Cubo
authors.forename: José M Trejo
authors.initials: JM
authors.lastname: Gabriel-Galán
authors.forename: Joaquin Seco
authors.initials: JS
authors.lastname: Martínez
authors.forename: Carlos Rioja
authors.initials: CR
authors.lastname: Alcubilla
authors.forename: Chengwu
authors.initials: C
authors.lastname: Yang
authors.forename: Olga Fernández
authors.initials: OF
authors.lastname: Arconada
authors.forename: Natividad Mariscal
authors.initials: NM
authors.lastname: Pérez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D020407:Internet / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012720:Severity of Illness Index