title: Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study.
abstract: Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.
authors.affiliation: Swiss Teratogen Information Service, STIS, Centre Hospitalier Universitaire Vaudois, Beaumont-6ème étage, 1011 Lausanne, Switzerland. Alice.Panchaud@chuv.ch
authors.forename: Alice
authors.initials: A
authors.lastname: Panchaud
authors.forename: Chantal
authors.initials: C
authors.lastname: Csajka
authors.forename: Paul
authors.initials: P
authors.lastname: Merlob
authors.forename: Christof
authors.initials: C
authors.lastname: Schaefer
authors.forename: Maya
authors.initials: M
authors.lastname: Berlin
authors.forename: Marco
authors.initials: M
authors.lastname: De Santis
authors.forename: Thierry
authors.initials: T
authors.lastname: Vial
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ieri
authors.forename: Heli
authors.initials: H
authors.lastname: Malm
authors.forename: Georgios
authors.initials: G
authors.lastname: Eleftheriou
authors.forename: Bracha
authors.initials: B
authors.lastname: Stahl
authors.forename: Philippe
authors.initials: P
authors.lastname: Rousso
authors.forename: Ursula
authors.initials: U
authors.lastname: Winterfeld
authors.forename: Laura E
authors.initials: LE
authors.lastname: Rothuizen
authors.forename: Thierry
authors.initials: T
authors.lastname: Buclin
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012176:Retinoids / Q000008:administration & dosage*; D012871:Skin Diseases / Q000188:drug therapy; D055815:Young Adult
chemical_list: D012176:Retinoids