title: Synthesis and characterization of a multi-sensitive crosslinked injectable hydrogel based on Pluronic.
abstract: This paper reports the construction of a novel multi-sensitive chemically crosslinked injectable hydrogel with strong mechanical strength by modifying Pluronic F127 responsive against temperature, pH and redox potential. Crosslinked polymer between benzaldehyde grafted Pluronic (P-A) and amine end capped Pluronic having disulfide linkage (P-B) have been synthesized and characterized with 1H NMR spectroscopy and GPC. The hydrogel under physiological conditions significantly altered sol-gel transition behaviors with much lower critical gelation concentrations and temperatures, compared to Pluronic hydrogels. The rheological characterization demonstrated that the moduli of the hydrogels were able to be tuned depending on molecular weight as well as pH, redox and temperature conditions.
authors.affiliation: Department of Chemical & Biological Engineering, Chungju National University, Chungju, Republic of Korea.
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Nam
authors.lastname: Abdullah-Al-Nahain
authors.forename: Seonki
authors.initials: S
authors.lastname: Hong
authors.forename: Kang Dae
authors.initials: KD
authors.lastname: Lee
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.forename: Sung Young
authors.initials: SY
authors.lastname: Park
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000494:pharmacology; D004220:Disulfides / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007267:Injections; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D010084:Oxidation-Reduction; D044367:Phase Transition; D020442:Poloxamer / Q000737:chemistry*; D013696:Temperature
chemical_list: D001547:Benzaldehydes; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004220:Disulfides; D020100:Hydrogels; D020442:Poloxamer; C032175:benzaldehyde