title: Compartment syndrome due to massive leg hematoma after primary total hip arthroplasty: a previously unreported complication of fondaparinux.
abstract: Fondaparinux is an accepted form of deep venous thrombosis prophylaxis after hip arthroplasty. Cited advantages of its use include once-daily administration, standard dosage, and superiority as compared with enoxaparin. However, there have been several case reports of serious associated bleeding complications. We describe the case of a 77-year-old woman who developed a massive leg hematoma in the operative extremity nearly 3 weeks after a primary total hip arthroplasty while on fondaparinux. The patient developed a compartment syndrome requiring decompression of the hematoma, fasciotomy, and subsequent additional plastic surgery for split thickness skin grafting.
authors.affiliation: Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hannon
authors.forename: Justin G
authors.initials: JG
authors.lastname: Lamont
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D003161:Compartment Syndromes / Q000209:etiology*; D019299:Decompression, Surgical; D005260:Female; D000077425:Fondaparinux; D006406:Hematoma / Q000139:chemically induced* / Q000150:complications*; D006801:Humans; D007866:Leg; D015207:Osteoarthritis, Hip / Q000601:surgery*; D011134:Polysaccharides / Q000009:adverse effects* / Q000627:therapeutic use; D016038:Skin Transplantation; D013518:Surgery, Plastic; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D011134:Polysaccharides; D000077425:Fondaparinux