title: Modification of chitosan-methylcellulose composite films with meso-tetrakis(4-sulfonatophenyl)porphyrin.
abstract: Polysaccharide films containing chitosan, methylcellulose, and a mixture of these polysaccharides in various ratios were prepared and modified with meso-tetrakis(4-sulfonatophenyl)porphyrin in an aqueous medium at pH 7. The modified films were compared with the initial films using spectroscopic methods and microscopic imaging. Electronic (UV-vis absorption, electronic circular dichroism (ECD)) and vibrational (FTIR and Raman) spectra showed that the porphyrin macrocycles had a strong affinity toward chitosan and did not interact with the methylcellulose. The total porphyrin uptake depended on the chitosan: methylcellulose ratio and pure methylcellulose films did not retain porphyrin macrocycles. ECD measurements detected the presence of optically active porphyrin species bound to the films. SEM and AFM images confirmed that the porphyrin macrocycles caused structural changes on the film surface and within the film layer.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemical Technology in Prague, 166 28 Prague, The Czech Republic. sinical@vscht.cz
authors.forename: Alla
authors.initials: A
authors.lastname: Synytsya
authors.forename: Michaela
authors.initials: M
authors.lastname: Grafová
authors.forename: Petr
authors.initials: P
authors.lastname: Slepicka
authors.forename: Ondrej
authors.initials: O
authors.lastname: Gedeon
authors.forename: Andriy
authors.initials: A
authors.lastname: Synytsya
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D048271:Chitosan / Q000737:chemistry*; D002942:Circular Dichroism; D016503:Drug Delivery Systems / Q000379:methods; D006863:Hydrogen-Ion Concentration; D008747:Methylcellulose / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014867:Water
chemical_list: D001672:Biocompatible Materials; D011166:Porphyrins; C092400:meso-tetrakis(4-sulfonatophenyl)porphyrin; D014867:Water; D008747:Methylcellulose; D048271:Chitosan