title: Molecular profiling of aggressive lymphomas.
abstract: In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.
authors.affiliation: Molecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology "L. and A. Seràgnoli", S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Maura
authors.initials: M
authors.lastname: Rossi
authors.forename: Maria Antonella
authors.initials: MA
authors.lastname: Laginestra
authors.forename: Anna
authors.initials: A
authors.lastname: Gazzola
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Sapienza
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Piccaluga