title: [Necessity to evaluate the genetic safety of xenobiotics in mammalian experiments].
abstract: The need to obligatorily evaluate the genetic safety of factors in in vivo experiments is substantiated by the body's protective systems, toxicokinetic features, organ specificity, and the pattern of time and dose dependencies. To substantiate the need for in vivo studies, the author gives the results of long-term studies by the laboratory of genetic monitoring and considers the features of mutagen testing in mammalian versus in vitro experiments. She presents the system developed at the Institute to evaluate the mutagenic properties of environmental factors, by taking into account the organ specificity, the basis of which is a multiorgan karyological analysis. Being a good tool to study the regularities of the toxic action of xenobiotics, this approach is of important scientific and practical value.
authors.forename: L P
authors.initials: LP
authors.lastname: Sycheva
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics* / Q000633:toxicity*; D009928:Organ Specificity; D051381:Rats; D012449:Safety; D013997:Time Factors; D014018:Tissue Distribution; D015262:Xenobiotics / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D009153:Mutagens; D015262:Xenobiotics