title: Distribution of HLA-B27 and  CYP2D6*4 mutations in the middle Black Sea area (Tokat) of Turkey.
abstract: We  analyzed distribution of HLA-B27 and CYP2D6*4 mutations in 249 patients from  Tokat province in Turkey with symptoms of arthritis, sacroiliac, joint and back  pain, using a LightCycler 480 II Real-Time PCR thermal cycler. The Genes-4U was  applied for studying HLA-B27 mutation, and the Tib-Molbiol commercial kit was  used to examine the CYP2D6*4 mutation. Among the 249 patients, 18.5% had the  HLA-B27 mutation. The CYP2D6*4 mutation was found in 22.0% (six homozygotes).  Ten patients had both mutations. These frequencies are similar to what has been  reported from other populations.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey. semsettinsahin@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Sahin
authors.forename: L
authors.initials: L
authors.lastname: Aydogan
authors.forename: I
authors.initials: I
authors.lastname: Benli
authors.forename: H
authors.initials: H
authors.lastname: Ozyurt
mesh_terms: D001168:Arthritis / Q000235:genetics* / Q000473:pathology; D001416:Back Pain / Q000235:genetics* / Q000276:immunology; D059038:Black Sea; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D009154:Mutation; D060888:Real-Time Polymerase Chain Reaction; D012446:Sacroiliac Joint / Q000473:pathology; D014421:Turkey
chemical_list: D015796:HLA-B27 Antigen; D019389:Cytochrome P-450 CYP2D6