title: [Fast recovery of haemodynamic and ventilatory functions after sugammadex bolus following rocuronium-induced anaphylactic shock refractory to conventional treatment].
abstract: Recently, three case reports have suggested the possible efficacy of sugammadex in anaphylactic shock refractory to conventional treatment induced by rocuronium. We report a new case of severe anaphylactic reaction to rocuronium treated with sugammadex. After 18 minutes of conventional treatment because of persistent cardiocirculatory failure and bronchospasm, a bolus of 2000 mg (18 mg/kg) of sugammadex was injected. This was associated with rapid correction of arterial hypotension and bronchoconstriction. The underlying pathophysiological mechanisms that explain the potential beneficial effect of sugammadex in this context are unknown but it is important to know that refractory anaphylactic shock to rocuronium can be potentially corrected with sugammadex.
authors.affiliation: Département d'anesthésie-réanimation, Nancy université, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandœuvre-lès-Nancy, France. j.raft@nancy.fnclcc.fr
authors.forename: J
authors.initials: J
authors.lastname: Raft
authors.forename: M
authors.initials: M
authors.lastname: Leclercq
authors.forename: D
authors.initials: D
authors.lastname: Longrois
authors.forename: C
authors.initials: C
authors.lastname: Meistelman
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy*; D000732:Androstanols / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D012123:Pulmonary Ventilation; D020127:Recovery of Function; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium