title: Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents.
abstract: A series of resveratrol derivatives possessing curcumin moiety were synthesized and evaluated for their antiproliferative activity against three cancer cell lines including murine melanoma B16-F10, human hepatoma HepG2 and human lung carcinoma A549. Among them, compound C5 displayed the most potent in vitro antiproliferative activity against B16-F10 with IC(50) value of 0.71 μg/mL. Compound C5 also exhibited good tubulin polymerization inhibitory activity with IC(50) value of 1.45 μg/mL. Furthermore, docking simulation was carried out to position C5 into the tubulin-colchicine binding site to determine the probable binding mode.
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei 230009, PR China.
authors.forename: Ban-Feng
authors.initials: BF
authors.lastname: Ruan
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Li
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Tang
authors.forename: Yao
authors.initials: Y
authors.lastname: Wei
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Wang
authors.forename: Shi-Li
authors.initials: SL
authors.lastname: Zheng
authors.forename: Ri-Sheng
authors.initials: RS
authors.lastname: Yao
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D059447:Cell Cycle Checkpoints; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D003474:Curcumin / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D017434:Protein Structure, Tertiary; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism; D050257:Tubulin Modulators / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; D014404:Tubulin; D050257:Tubulin Modulators; D003474:Curcumin; D000077185:Resveratrol