title: Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation.
abstract: Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl(2)) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl(2) into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation.
authors.affiliation: Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: Erica M
authors.initials: EM
authors.lastname: Granjeiro
authors.forename: Felipe V
authors.initials: FV
authors.lastname: Gomes
authors.forename: Fernando H F
authors.initials: FH
authors.lastname: Alves
authors.forename: Carlos C
authors.initials: CC
authors.lastname: Crestani
authors.forename: Fernando M A
authors.initials: FM
authors.lastname: Corrêa
authors.forename: Leonardo B M
authors.initials: LB
authors.lastname: Resstel
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D011190:Potassium Cyanide / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000502:physiology*; D012686:Septal Nuclei / Q000502:physiology*; D013268:Stimulation, Chemical
chemical_list: D003035:Cobalt; D011189:Potassium Chloride; C018021:cobaltous chloride; D011190:Potassium Cyanide