title: Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates.
abstract: Carbohydrates in various forms play a vital role in numerous critical biological processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line.
authors.affiliation: Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA. Electronic address: scraig30@gmail.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Craig
mesh_terms: D000818:Animals; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002460:Cell Line; D002522:Chlorocebus aethiops; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D018613:Microscopy, Confocal; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes; D010616:Phenanthrenes