title: Optimal preparation-to-colonoscopy interval in split-dose PEG bowel preparation determines satisfactory bowel preparation quality: an observational prospective study.
abstract: BACKGROUND
  Several factors influence bowel preparation quality. Recent studies have indicated that the time interval between bowel preparation and the start of colonoscopy is also important in determining bowel preparation quality.
  
  
  OBJECTIVE
  To evaluate the influence of the preparation-to-colonoscopy (PC) interval (the interval of time between the last polyethylene glycol dose ingestion and the start of the colonoscopy) on bowel preparation quality in the split-dose method for colonoscopy.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  A total of 366 consecutive outpatients undergoing colonoscopy.
  
  
  METHODS
  Split-dose bowel preparation and colonoscopy.
  
  
  METHODS
  The quality of bowel preparation was assessed by using the Ottawa Bowel Preparation Scale according to the PC interval, and other factors that might influence bowel preparation quality were analyzed.
  
  
  RESULTS
  Colonoscopies with a PC interval of 3 to 5 hours had the best bowel preparation quality score in the whole, right, mid, and rectosigmoid colon according to the Ottawa Bowel Preparation Scale. In multivariate analysis, the PC interval (odds ratio [OR] 1.85; 95% CI, 1.18-2.86), the amount of PEG ingested (OR 4.34; 95% CI, 1.08-16.66), and compliance with diet instructions (OR 2.22l 95% CI, 1.33-3.70) were significant contributors to satisfactory bowel preparation.
  
  
  CONCLUSIONS
  Nonrandomized controlled, single-center trial.
  
  
  CONCLUSIONS
  The optimal time interval between the last dose of the agent and the start of colonoscopy is one of the important factors to determine satisfactory bowel preparation quality in split-dose polyethylene glycol bowel preparation.
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Seo
authors.forename: Tae Oh
authors.initials: TO
authors.lastname: Kim
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Park
authors.forename: Hee Rin
authors.initials: HR
authors.lastname: Joo
authors.forename: Nae Yun
authors.initials: NY
authors.lastname: Heo
authors.forename: Jongha
authors.initials: J
authors.lastname: Park
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Sung Yeon
authors.initials: SY
authors.lastname: Yang
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Moon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics / Q000008:administration & dosage*; D003113:Colonoscopy / Q000379:methods* / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols