title: Polymorphism of the prion protein gene (PRNP) in Polish cattle affected by classical bovine spongiform encephalopathy.
abstract: Recent attempts to discover genetic factors affecting cattle resistance/susceptibility to bovine spongiform encephalopathy (BSE) have led to the identification of two insertion/deletion (indel) polymorphisms, located within the promoter and intron 1 of the prion protein gene PRNP, showing a significant association with the occurrence of classical form of the disease. Because the effect of the polymorphisms was studied only in few populations, in this study we investigated whether previously described association of PRNP indel polymorphisms with BSE susceptibility in cattle is also present in Polish cattle population. We found a significant relation between the investigated PRNP indel polymorphisms (23 and 12 bp indels), and susceptibility of Polish Holstein-Friesian cattle to classical BSE (P < 0.05). The deletion variants of both polymorphisms were related to increased susceptibility, whereas insertion variants were protective against BSE.
authors.affiliation: Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice n. Krakow, Poland. agurgul@izoo.krakow.pl
authors.forename: Artur
authors.initials: A
authors.lastname: Gurgul
authors.forename: Urszula
authors.initials: U
authors.lastname: Czarnik
authors.forename: Czarnik
authors.initials: C
authors.lastname: Urszula
authors.forename: Magdalena
authors.initials: M
authors.lastname: Larska
authors.forename: Mirosław P
authors.initials: MP
authors.lastname: Polak
authors.forename: Janusz
authors.initials: J
authors.lastname: Strychalski
authors.forename: Ewa
authors.initials: E
authors.lastname: Słota
mesh_terms: D000483:Alleles; D000818:Animals; D001947:Breeding; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005858:Germany; D006239:Haplotypes / Q000235:genetics; D054643:INDEL Mutation / Q000235:genetics; D007438:Introns / Q000235:genetics; D016366:Open Reading Frames / Q000235:genetics; D011044:Poland; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D011328:Prions