title: Lead Diversification 2: application to P38, gMTP and lead compounds.
abstract: Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C-H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. mabidmasood@gmail.com; abid.masood@pfizer.com
authors.forename: M Abid
authors.initials: MA
authors.lastname: Masood
authors.forename: Marc
authors.initials: M
authors.lastname: Bazin
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bunnage
authors.forename: Andrew
authors.initials: A
authors.lastname: Calabrese
authors.forename: Mark
authors.initials: M
authors.lastname: Cox
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Fancy
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Farrant
authors.forename: David W
authors.initials: DW
authors.lastname: Pearce
authors.forename: Manuel
authors.initials: M
authors.lastname: Perez
authors.forename: Laure
authors.initials: L
authors.lastname: Hitzel
authors.forename: Torren
authors.initials: T
authors.lastname: Peakman
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D047428:Protein Kinase Inhibitors; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010165:Palladium; D048051:p38 Mitogen-Activated Protein Kinases