title: Sulfonyl imidazolium salts as reagents for the rapid and efficient synthesis of nucleoside polyphosphates and their conjugates.
abstract: A procedure for the synthesis of nucleoside polyphosphates and their conjugates using sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high yielding, does not require prior protection and subsequent deprotection of the donors or acceptors, and can be used to activate nucleoside mono-, di- and triphosphates, and a wide variety of acceptors and donors can be used.
authors.affiliation: Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt 41522
authors.forename: Samy
authors.initials: S
authors.lastname: Mohamady
authors.forename: Ahmed
authors.initials: A
authors.lastname: Desoky
authors.forename: Scott D
authors.initials: SD
authors.lastname: Taylor
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D011122:Polyphosphates / Q000138:chemical synthesis*; D013441:Sulfinic Acids / Q000737:chemistry*; D013997:Time Factors
chemical_list: D002241:Carbohydrates; D007093:Imidazoles; D009705:Nucleosides; D011122:Polyphosphates; D013441:Sulfinic Acids