title: Preparation of a new electrochemical sensor based on iron (III) complexes modified carbon paste electrode for simultaneous determination of mefenamic acid and indomethacin.
abstract: A new chemically modified carbon paste electrodes based on Fe (III) schiff base (Fe (III)-SBMCP)-containing graphite pastes were prepared and evaluated as electrochemical sensor for the voltammetric determination of mefenamic acid and indomethacin in aqueous solutions. The measurements were carried out by application of the differential pulse voltammetry (DPV) method in phosphate buffer solution with pH 3.5. Fe (III) loaded in schiff base can increase anodic peak currents by adsorption of mefenamic acid and indomethacin on electrode surface. The prepared electrode shows voltammetric responses with high sensitivity for mefenamic acid and indomethacin in optimal conditions, which makes it very suitable for simultaneous determination of these compounds. The proposed method was successfully applied for determination mefenamic acid and indomethacin in commercial tablet samples.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. mhmmd_hasanzadeh@yahoo.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hasanzadeh
authors.forename: Nasrin
authors.initials: N
authors.lastname: Shadjou
authors.forename: Lotfali
authors.initials: L
authors.lastname: Saghatforoush
authors.forename: Jafar Ezzati Nazhad
authors.initials: JE
authors.lastname: Dolatabadi
mesh_terms: D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004560:Electricity; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000032:analysis* / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D057230:Limit of Detection; D008528:Mefenamic Acid / Q000032:analysis* / Q000737:chemistry; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D012545:Schiff Bases / Q000737:chemistry; D013997:Time Factors
chemical_list: D012545:Schiff Bases; D008528:Mefenamic Acid; D002244:Carbon; D007501:Iron; D007213:Indomethacin