title: Optical modeling of a corneal inlay in real eyes to increase depth of focus: optimum centration and residual defocus.
abstract: OBJECTIVE
  To determine the optimum position to center a small-aperture corneal inlay and the effect of residual defocus in the surgical eye to maximize depth of focus.
  
  
  METHODS
  Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Personalized eye models were built using actual data (corneal topography, eye length, ocular aberrations, and eye alignment). A small aperture 1.6 mm in diameter was placed at the corneal plane in each model. The monochromatic and polychromatic Strehl ratios were calculated as a function of the pinhole position. Different residual defocus values were also incorporated into the models, and the through-focus Strehl ratios were calculated.
  
  
  RESULTS
  Sixteen eye models were built. For most subjects, the optimum location of the aperture for distance vision was close to the corneal reflex position. For a given optimized centration of the aperture, the best compromise of depth of focus was obtained when the eyes had some residual myopic defocus (range -0.75 to -1.00 diopter [D]). Strehl ratio values were over 0.1 for far distance, which led to visual acuities better than 20/20. The depth of focus was 2.50 D with a mean near visual acuity of Jaeger 1 or better.
  
  
  CONCLUSIONS
  In eyes with little astigmatism and aberrations, the optimum centration of the small aperture was near the corneal reflex position. To improve optical outcomes with the inlay, some small residual myopia and correction of corneal astigmatism might be required.
authors.affiliation: Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Tabernero
authors.forename: Pablo
authors.initials: P
authors.lastname: Artal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery; D058452:Axial Length, Eye; D015331:Cohort Studies; D003319:Corneal Stroma / Q000601:surgery*; D019781:Corneal Topography; D003867:Depth Perception / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D008962:Models, Theoretical; D009216:Myopia / Q000503:physiopathology / Q000601:surgery; D011305:Presbyopia / Q000503:physiopathology / Q000601:surgery; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012029:Refraction, Ocular / Q000502:physiology; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology*