title: Shaping development with ESCRTs.
abstract: Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.
authors.affiliation: Centre for Cancer Biomedicine, Oslo University Hospital, Montebello, 0310 Oslo, Norway.
authors.forename: Tor Erik
authors.initials: TE
authors.lastname: Rusten
authors.forename: Thomas
authors.initials: T
authors.lastname: Vaccari
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D000818:Animals; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D006801:Humans; D057146:Multivesicular Bodies / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport