title: Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent.
abstract: Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.
authors.affiliation: Centre for Strategic Nano-Fabrication, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia.
authors.forename: Selvi
authors.initials: S
authors.lastname: Dev
authors.forename: Praseetha
authors.initials: P
authors.lastname: Prabhakaran
authors.forename: Luis
authors.initials: L
authors.lastname: Filgueira
authors.forename: K Swaminathan
authors.initials: KS
authors.lastname: Iyer
authors.forename: Colin L
authors.initials: CL
authors.lastname: Raston
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D003474:Curcumin / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D046210:Microfluidic Analytical Techniques; D053758:Nanoparticles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D000644:Quaternary Ammonium Compounds; D011960:Receptors, Estrogen; D020442:Poloxamer; C046112:didodecyldimethylammonium; D003474:Curcumin