title: Glut-1 Expression Correlates with Basal-like Breast Cancer.
abstract: BACKGROUND
  Glucose transporter 1 (Glut-1) is a facilitative glucose transporter expressed in many cancers including breast cancer. Basal-like breast cancer (BLBC) is a high-risk disease associated with poor prognosis and lacks the benefit of targeted therapy. The aim of this study was to characterize the immunohistochemical (IHC) expression of Glut-1 in patients with BLBC compared with non-BLBC.
  
  
  METHODS
  We identified 523 cases of invasive breast carcinoma from our database. The clinicopathologic findings and the biologic markers including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2) status were reviewed. IHC stains for cytokeratin 5/6 (CK5/6), epidermal growth factor receptor (EGFR), p53, and Glut-1 were performed on tissue microarray using standard procedures. BLBC was defined as ER-,PR-, Her2-, and CK5/6+ and/or EGFR+.
  
  
  RESULTS
  Of informative cases, 14.7% were categorized as BLBC versus 85.3% as non-BLBC. Glut-1 was expressed in 42 (76.4%) of 55 BLBCs, whereas only 55 (23.8%) of 231 non-BLBCs showed immunostaining for Glut-1 (P < .001). Overall, Glut-1 expression was significantly associated with high histologic grade, ER negativity, PR negativity, CK5/6 positivity, EGFR expression, and high p53 expression (P < .001). However, there was no correlation between Glut-1 immunostaining and patient's outcome.
  
  
  CONCLUSIONS
  Our results show that Glut-1 is significantly associated with BLBC and might be a potential therapeutic target for this aggressive subgroup of breast cancer, and this warrants further investigations.
authors.affiliation: Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Yaser R
authors.initials: YR
authors.lastname: Hussein
authors.forename: Sudeshna
authors.initials: S
authors.lastname: Bandyopadhyay
authors.forename: Assaad
authors.initials: A
authors.lastname: Semaan
authors.forename: Quratulain
authors.initials: Q
authors.lastname: Ahmed
authors.forename: Bassam
authors.initials: B
authors.lastname: Albashiti
authors.forename: Tarek
authors.initials: T
authors.lastname: Jazaerly
authors.forename: Zeina
authors.initials: Z
authors.lastname: Nahleh
authors.forename: Rouba
authors.initials: R
authors.lastname: Ali-Fehmi