title: Effects of the consumption of caffeinated and decaffeinated instant coffee beverages on oxidative stress induced by strenuous exercise in rats.
abstract: Many authors attribute the antioxidant activity of brewed coffee to its caffeine content. In addition, caffeine intake has been associated with increased performance during physical exercise. This study analyzed the in vivo effects of drinking caffeinated and decaffeinated instant coffee (8%, w/v) on oxidative stress and antioxidant enzyme activity in the anterior tibialis muscles of rats subjected to intense exercise. It was observed that exercise induced lipid peroxidation (estimated using malondialdehyde) and protein oxidation (evaluated by determining the formation of carbonyl groups) in the muscle (P < 0.05). Decaffeinated instant coffee and caffeine solution did not exhibit antioxidant activity in vivo. Caffeinated instant coffee beverage intake did not induce changes in superoxide dismutase and glutathione peroxidase activities but was able to diminish lipid and protein oxidation in the anterior tibialis muscles of rats after exercise (P < 0.05), contributing to a reduction in the oxidative stress triggered by exercise.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700. Centro, Alfenas, MG, Brazil.
authors.forename: André Luiz Machado
authors.initials: AL
authors.lastname: Viana
authors.forename: Miriam das Dores Mendes
authors.initials: Md
authors.lastname: Fonseca
authors.forename: Elisson Lamin Jerônimo
authors.initials: EL
authors.lastname: Meireles
authors.forename: Stella Maris da Silveira
authors.initials: SM
authors.lastname: Duarte
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Rodrigues
authors.forename: Fernanda Borges de Araujo
authors.initials: FB
authors.lastname: Paula
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D003069:Coffee; D005080:Exercise Test; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009132:Muscles / Q000201:enzymology / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011506:Proteins / Q000737:chemistry; D051381:Rats; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
chemical_list: D000975:Antioxidants; D003069:Coffee; D011506:Proteins; D002110:Caffeine; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase