title: [Familial diabetes frequency as a factor in diabetics suffering from cancer].
abstract: Although type 2 diabetes contributes to the risk of development of certain tumors; factors which modify this relationship need to be further examined. Familial diabetes frequency was followed in (a) diabetes-free cancer patients (132), aged 60.3 +/- 1.2; (b) cancer patients with apparent (62.3 +/- 0.4; n=371) or occult type 2 diabetes (61.6 +/- 1.2; n=65) and (c) cancer-free patients with type 2 diabetes (61.8 +/- 0.4; n=237); the latter group (172 females and 65 males) featured almost identical diabetes frequencies: 30.8 +/- 3.5% and 30.8 +/- 5.7%, respectively. They significantly exceeded a relevant index occurring in families free from cancer concomitant with diabetes (6.1 +/- 2.1%). Significantly lower frequencies of familial diabetes were reported in cancer patients as compared with cancer-free patients (12.9 +/- 2.1% females, p < or = 0.01; 19.4 +/- 3.8% - males, p=0.1). To sum up, it cannot be ruled out that familial diabetes is a marker of relative decrease in potential risk of cancer rather than that of increase. The causes of this phenomenon and its possible dependence on gender need to be explored.
authors.forename: L M
authors.initials: LM
authors.lastname: Bershteĭn
authors.forename: M P
authors.initials: MP
authors.lastname: Boriakina
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Teslenko
authors.forename: D A
authors.initials: DA
authors.lastname: Vasil'ev
mesh_terms: D048909:Diabetes Complications / Q000453:epidemiology* / Q000235:genetics; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D012306:Risk; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors