title: Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells.
abstract: Ultraviolet B (UVB) radiation may cause the inflammation of retinal pigment epithelium (RPE) cells and play a role in development of age-related macular degeneration (AMD). The activation of the complement factor B (CFB) gene has been shown to be involved in formation of AMD. Here our results revealed that UVB induces IL-6/STAT3 signaling activation and the UVB-induced STAT3 is able to regulate the CFB expression in ARPE-19 cells. Tannic acid (TA) is a kind of water-soluble polyphenol and may have anti-inflammation effects. We also found that TA attenuates the UVB-induced IL-6 protein production, the STAT3 phosphorylation and the CFB expression. Taken together, these findings suggest UVB-induced inflammation of RPE can be mediated through the IL-6/STAT3/CFB pathway, and TA has a protected effect via the inhibition to the inflammatory response.
authors.affiliation: Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Chou
authors.forename: Yung-Song
authors.initials: YS
authors.lastname: Wang
authors.forename: Ku-Chung
authors.initials: KC
authors.lastname: Chen
authors.forename: Jing-Mei
authors.initials: JM
authors.lastname: Wu
authors.forename: Chung-Ling
authors.initials: CL
authors.lastname: Liang
authors.forename: Suh-Hang Hank
authors.initials: SH
authors.lastname: Juo
mesh_terms: D002460:Cell Line; D011415:Complement Factor B / Q000235:genetics / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology*; D008268:Macular Degeneration / Q000209:etiology / Q000276:immunology; D012313:RNA / Q000737:chemistry / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D055213:Retinal Pigment Epithelium / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000276:immunology*; D015398:Signal Transduction; D013634:Tannins / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D015850:Interleukin-6; D050796:STAT3 Transcription Factor; D013634:Tannins; D012313:RNA; D011415:Complement Factor B