title: N-arylbenzamides: extremely simple scaffolds for the development of novel estrogen receptor agonists.
abstract: The research of estrogen receptor (ER) ligands has benefited in the last decade from the implementation of combinatorial chemistry. The general pharmacophore has been identified and subsequently a multitude of compounds have been synthesized. Surprisingly, up to now simple amides have not been taken into consideration. Here we show that amides resulting from the condensation of hydroxybenzoic acids with aminophenols result in compounds retaining the pharmacophore structure of an ER ligand with a clear estrogenic activity.
authors.affiliation: DISCAFF & DFB Center, Università degli Studi del Piemonte Orientale A. Avogadro, Novara, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Caldarelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Minazzi
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Canonico
authors.forename: Armando A
authors.initials: AA
authors.lastname: Genazzani
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Giovenzana
mesh_terms: D000627:Aminophenols / Q000737:chemistry; D001549:Benzamides / Q000737:chemistry*; D002460:Cell Line; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry; D011960:Receptors, Estrogen / Q000819:agonists*; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship
chemical_list: D000627:Aminophenols; D001549:Benzamides; D062385:Hydroxybenzoates; D011960:Receptors, Estrogen; D054852:Small Molecule Libraries; C037689:benzamide