title: Co-infection of Dengue virus by serotypes 3 and 4 in patients from Amazonas, Brazil.
abstract: The natural co-infection with dengue virus can occur in highly endemic areas where different serotypes have been observed for many years. We report here four cases of DENV-3/DENV-4 co-infection detected by serological and molecular tests among 674 patients with acute undifferentiated fever from the tropical medicine reference center of Manaus City, Brazil, between 2005 and 2010. Analysis of the sequences obtained indicated the presence of genotype 3 and 1 for DENV-3 and DENV-4 respectively.
authors.affiliation: Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brazil. figueiredormp@yahoo.com.br
authors.forename: Regina M P de
authors.initials: RM
authors.lastname: Figueiredo
authors.forename: Felipe Gomes
authors.initials: FG
authors.lastname: Naveca
authors.forename: Cintia Mara
authors.initials: CM
authors.lastname: Oliveira
authors.forename: Michele de Souza
authors.initials: Mde S
authors.lastname: Bastos
authors.forename: Maria Paula Gomes
authors.initials: MP
authors.lastname: Mourão
authors.forename: Suziane de S
authors.initials: Sde S
authors.lastname: Viana
authors.forename: Miriam do N
authors.initials: Mdo N
authors.lastname: Melo
authors.forename: Evaulino F
authors.initials: EF
authors.lastname: Itapirema
authors.forename: Cassiano J
authors.initials: CJ
authors.lastname: Saatkamp
authors.forename: Izeni P
authors.initials: IP
authors.lastname: Farias
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D060085:Coinfection / Q000821:virology*; D003715:Dengue / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012703:Serotyping