title: A case of malignant migrating partial seizures in infancy as a continuum of infantile epileptic encephalopathy.
abstract: The syndrome of malignant migrating partial seizures in infancy (MMPSI) is characterized by onset before the age of 6 months, nearly continuous electrographic seizures involving multiple independent areas of onset in both hemispheres, and poor developmental outcome. This report presents a case involving a patient with MMPSI, who later developed West syndrome. At the age of 2 months old, he showed multifocal partial seizures, which were refractory to antiepileptic drugs. His electroencephalogram (EEG) revealed characteristic migrating multifocal epileptiform activities and neuroimaging finding was normal. The focal seizures were refractory to antiepileptic drugs and ketogenic diet. When he was 9 months old, epilepic spasms were observed with hypsarrhythmia on EEG. He also showed severe developmental delay. MMPSI may be a continuum of infantile epileptic encephalpathy and could evolve to West syndrome.
authors.affiliation: Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Lee
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Yum
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Jeong
authors.forename: Kyung Yeon
authors.initials: KY
authors.lastname: Lee
authors.forename: Tae-Sung
authors.initials: TS
authors.lastname: Ko
mesh_terms: D002540:Cerebral Cortex / Q000473:pathology; D004828:Epilepsies, Partial / Q000150:complications / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000209:etiology*; D013036:Spasms, Infantile / Q000150:complications*