title: [Effects of proton pump inhibitors on in-stent restenosis in patients receiving clopidogrel: a retrospective analysis].
abstract: To determine the effect of proton pump inhibitor (PPI) on in-stent restenosis (ISR) in patients receiving clopidogrel therapy.
  
  
  
  Total 439 patients underwent percutaneous coronary intervention (PCI) were enrolled in the study,including 250 post-PCI patients discharged on clopidogrel alone and 189 patients discharged on clopidogrel with PPI. The in-stent restenosis (ISR) ratio of the patients in these two groups were observed.
  
  
  
  During a mean follow-up period of (13 ± 5.9) months, the post-PCI patients discharged on concomitant clopidogrel-PPI therapy had higher risk of ISR than those discharged on clopidogrel alone (19.6% Compared with 8%, P<0.001).
  
  
  
  Concomitant use of clopidogrel and PPI after hospital discharge would increase the risk of ISR for post-PCI patients.
authors.affiliation: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. alu520511@163.com
authors.forename: Zhan-lu
authors.initials: ZL
authors.lastname: Li
authors.forename: Bin-quan
authors.initials: BQ
authors.lastname: Zhou
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Zhu
authors.forename: Guo-sheng
authors.initials: GS
authors.lastname: Fu
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000077144:Clopidogrel; D023903:Coronary Restenosis / Q000209:etiology*; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D012306:Risk; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine