title: Rhodium-catalyzed asymmetric arylation of N-(tert-butanesulfinyl)imines with sodium tetraarylborates.
abstract: A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl)imines with sodium tetraarylborates is described. This method is general for constructing various chiral α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.
authors.affiliation: Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. rajender.leleti@novartis.com
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
authors.forename: Aditya P
authors.initials: AP
authors.lastname: Gupta
authors.forename: Eric
authors.initials: E
authors.lastname: Villhauer
authors.forename: Yugang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001881:Borates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001881:Borates; D011759:Pyrrolidines; D012238:Rhodium