title: [Liver regeneration after its mechanical injury in rats receiving biologically active substances "Trepel" and "Suvar"].
abstract: The effect of biologically active substances (BAS) "Trepel" and "Suvar" on liver regeneration 1-30 days after its mechanical injury was studied using histological and morphometric methods in 110 rat pups aged 18 days. The control group comprised 90 animals that received no treatment following liver injury. It was shown that both BAS studied inhibited the inflammatory reaction around the injury focus, suppressed collagenogenesis and activated hepatocyte proliferation.This resulted in the significant substitution of the damaged area by the hepatocytes, that was absent in the control animals. In animals treated with BAS, the numbers of binucleated and mitotically dividing hepatocytes was increased, while the amount of hepatocytes with dystrophic changes was reduced. Authors associate the positive effect of BAS on liver structure regeneration with their growth-promoting activity, resulting in the hypertrophy of different organs, including the thyroid and the adrenal glands, that is accompanied by an excessive production of the respective hormones displaying their physiological actions.
authors.forename: L P
authors.initials: LP
authors.lastname: Romanova
authors.forename: I I
authors.initials: II
authors.lastname: Malysheva
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects*; D051381:Rats; D013729:Terpenes / Q000494:pharmacology*; D017641:Zeolites / Q000494:pharmacology*
chemical_list: D013729:Terpenes; C083175:clinoptilolite; D017641:Zeolites