title: Toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome.
abstract: We report a case of toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. A healthy 20-year-old male soldier presented with confluent purpuric and erythematous dusky red macules evolving to flaccid blister and epidermal detachment on the whole body with conjunctival injection. The patient had no antecedent medical or surgical conditions except for two doses of hemorrhagic fever with renal syndrome vaccination. With supportive care, skin lesions were improved. Ophthalmic examinations revealed conjunctival injection with epithelial defects in both eyes. Ocular complications were resolved after amniotic membrane transplantation. Toxic epidermal necrolysis may be considered as a possible complication of hemorrhagic fever with renal syndrome vaccination.
authors.affiliation: Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Hwang
authors.forename: Myung Seung
authors.initials: MS
authors.lastname: Kang
authors.forename: Kyung O
authors.initials: KO
authors.lastname: Lim
authors.forename: Sang Mok
authors.initials: SM
authors.lastname: Lee
mesh_terms: D003229:Conjunctival Diseases / Q000209:etiology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000517:prevention & control*; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D014765:Viral Vaccines / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D014765:Viral Vaccines