title: Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation.
abstract: Composite nanoparticles have proved to be promising in a wide range of biotechnological applications. In this paper, we report on a facile method to synthesize novel Fe(3)O(4)/Au/Fe(3)O(4) nanoparticles (nanoflowers) that integrate hybrid components and surface types. We demonstrate that relative to conventional nanoparticles with core/shell configuration, such nanoflowers not only retain their surface plasmon property but also allow for 170% increase in the saturation magnetization and 23% increase in the conjugation efficiency due to the synergistic co-operation between the hierarchical structures. Moreover, we demonstrate that the magnetic properties of such composite nanoparticles can be tuned by controlling the size of additional petals (Fe(3)O(4) phase). These novel building blocks could open up novel and exciting vistas in nanomedicine for broad applications such as biosensing, cancer diagnostics and therapeutics, targeted delivery, and imaging.
authors.affiliation: The College of Life Sciences Northwest University, Xi'an, Shaanxi, China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Hui
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.forename: Mingli
authors.initials: M
authors.lastname: Peng
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Yanling
authors.initials: Y
authors.lastname: Luo
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chen
authors.forename: V A L
authors.initials: VA
authors.lastname: Roy
authors.forename: Yali
authors.initials: Y
authors.lastname: Cui
authors.forename: Zuankai
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D018796:Immunoconjugates / Q000737:chemistry; D007074:Immunoglobulin G; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D013053:Spectrophotometry; D014961:X-Ray Diffraction
chemical_list: D018796:Immunoconjugates; D007074:Immunoglobulin G; D058185:Magnetite Nanoparticles