title: Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals.
abstract: Simultaneous positron emission tomography (PET) and fluorescence tomography (FT) for in vivo imaging of small animals is proposed by a dual-modality system. This system combines a charge-coupled device-based near-infrared fluorescence imaging with a planar detector pair-based PET. With [(18)F]-2-fluoro-2-deoxy-d-glucose radioactive tracer and the protease activated fluorescence probe, on the one hand, the simultaneous metabolic activity and protease activity in tumor region are revealed by the PET and FT, respectively. On the other hand, the protease activity both on the surface layer and the deep tissue of the tumor is provided by the fluorescence reflection imaging and FT, respectively.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Shuangquan
authors.initials: S
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Xu
authors.forename: Jianwen
authors.initials: J
authors.lastname: Luo
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
mesh_terms: D000818:Animals; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18