title: Increase of lifespan for glioma-bearing rats by using minibeam radiation therapy.
abstract: This feasibility work assesses the therapeutic effectiveness of minibeam radiation therapy, a new synchrotron radiotherapy technique. In this new approach the irradiation is performed on 9L gliosarcoma-bearing rats with arrays of parallel beams of width 500-700 µm. Two irradiation configurations were compared: a lateral unidirectional irradiation and two orthogonal arrays interlacing at the target. A dose escalation study was performed. A factor of three gain in the mean survival time obtained for some animals paves the way for further exploration of the different possibilities of this technique and its further optimization.
authors.affiliation: ID17 Biomedical Beamline, European Synchrotron Radiation Facility, Grenoble, France. prezado@esrf.fr
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Prezado
authors.forename: Sukhena
authors.initials: S
authors.lastname: Sarun
authors.forename: Silvia
authors.initials: S
authors.lastname: Gil
authors.forename: Pierre
authors.initials: P
authors.lastname: Deman
authors.forename: Audrey
authors.initials: A
authors.lastname: Bouchet
authors.forename: Geraldine
authors.initials: G
authors.lastname: Le Duc
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D018316:Gliosarcoma / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D011874:Radiometry / Q000379:methods; D051381:Rats; D011916:Rats, Inbred F344; D015996:Survival Rate; D017356:Synchrotrons