title: Association between metabolic syndrome and serum leptin levels in postmenopausal women.
abstract: Menopausal status is associated with weight gain, increased central fat mass, abnormal lipid metabolism, insulin resistance and susceptibility to metabolic syndrome (MetS). Leptin is synthesised and secreted by adipocytes. Serum leptin levels are highly correlated with fat mass. We determined the association between MetS and serum leptin levels in 153 postmenopausal women. The difference in serum leptin level between MetS and non-MetS groups showed a statistical significance after adjusting for body mass index (BMI; 19.9 ± 9.5 vs 12.1 ± 5.9 ng/ml, p = 0.013). The indicator of abdominal obesity, waist-to-hip ratio (WHR) and visceral fat area (VFA), had a positive correlation with serum leptin level in non-obese subjects after adjusting for BMI (p = 0.017, p < 0.001, respectively). Of the components of MetS, abdominal obesity and the number of MetS components had a positive correlation with serum leptin level (p < 0.05, p < 0.001, respectively).
authors.affiliation: Department of Obstetrics and Gynecology, The Catholic University of Korea, St. Vincent Hospital, Suwon, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.forename: H H
authors.initials: HH
authors.lastname: Jo
authors.forename: M R
authors.initials: MR
authors.lastname: Kim
authors.forename: Y O
authors.initials: YO
authors.lastname: You
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D020738:Leptin