title: Neisseria gonorrhoeae with high-level resistance to azithromycin: case report of the first isolate identified in the United States.
abstract: We report on the first Neisseria gonorrhoeae isolate in the United States identified with high-level resistance to azithromycin. This report discusses the epidemiologic case investigation, the molecular studies of resistance-associated mutations and N. gonorrhoeae multiantigen sequence typing, and challenges posed by emerging gonococcal antimicrobial resistance.
authors.affiliation: Department of Public Health Sciences, John A Burns School of Medicine, University of Hawaii at Manoa, USA. katz@hawaii.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katz
authors.forename: Alan Y
authors.initials: AY
authors.lastname: Komeya
authors.forename: Olusegun O
authors.initials: OO
authors.lastname: Soge
authors.forename: Mandy I
authors.initials: MI
authors.lastname: Kiaha
authors.forename: Maria Veneranda C
authors.initials: MV
authors.lastname: Lee
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Wasserman
authors.forename: Eloisa V
authors.initials: EV
authors.lastname: Maningas
authors.forename: A Christian
authors.initials: AC
authors.lastname: Whelen
authors.forename: Robert D
authors.initials: RD
authors.lastname: Kirkcaldy
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Shapiro
authors.forename: Gail A
authors.initials: GA
authors.lastname: Bolan
authors.forename: King K
authors.initials: KK
authors.lastname: Holmes
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D006069:Gonorrhea / Q000382:microbiology*; D006254:Hawaii; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin