title: [Pre-and probiotics effectiveness in intestine microbiocenosis correction in patients after hemicolectomy].
abstract: Normal microflora plays a key role in ensuring and maintaining the health of human body. Currently, much attention is paid not only to rational, but the so-called optimal, or health nutrition, which includes individual selection of food, the most satisfying human needs for energy, plastic and regulatory components. The aim of our study was to evaluate the effectiveness of pre-and probiotics in correction of the intestine microbiocenosis, effect on the rate of the hyperendotoxemia and related functional changes in the liver and lipid metabolism. In our study, we identified changesof the intestine microbiocenosis, which led to endotoxemia to develop, and the associated changes in liver enzymes and lipid blood composition in patients after various variants of the hemicolectomy. During treatment were selected 50 patients with dysbiosis 2 - 4-th degree who underwent hemicolectomy. In the 1st groupwere patients (25 pat.) with the prevailing complaints of constipation that were performed therapy with lactulose prebiotics (Dyufalak) at 20 - 30 ml per day for 3 months. In the 2nd group were patients (25 pat.) with complaints of diarrhea and was conducted therapy with bifiform probiotic in a daily dose to 2 capsules 2 times a day for 3 months. The results of studies performed after treatment showed that the admission of pro-and prebiotics in patients after hemicolectomy, has a high efficiency in micro biocenosis restoring and had a positive effect not only on bacterial composition of the microflora, but also on the functional state of the liver and lipid levels in patients serum.
authors.forename: A I
authors.initials: AI
authors.lastname: Li
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Sil'vestrova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000009:adverse effects*; D019446:Endotoxemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D056692:Prebiotics; D019936:Probiotics / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D008055:Lipids; D056692:Prebiotics