title: The who, where, and when of IgE in allergic airway disease.
abstract: Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who"), their location ("where"), and the circumstances in which they are induced ("when"). We further consider the therapeutic implications of the insights gained.
authors.affiliation: Laboratorium of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium. melissa.dullaers@ugent.be
authors.forename: Melissa
authors.initials: M
authors.lastname: Dullaers
authors.forename: Ruth
authors.initials: R
authors.lastname: De Bruyne
authors.forename: Faruk
authors.initials: F
authors.lastname: Ramadani
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Gould
authors.forename: Philippe
authors.initials: P
authors.lastname: Gevaert
authors.forename: Bart N
authors.initials: BN
authors.lastname: Lambrecht
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D058990:Molecular Targeted Therapy; D010950:Plasma Cells / Q000276:immunology*; D012130:Respiratory Hypersensitivity / Q000276:immunology* / Q000628:therapy
chemical_list: D007073:Immunoglobulin E