title: Production and first use of 153SmCl3-ion exchange resin capsule formulation for assessing gastrointestinal motility.
abstract: We produced an enteric-coated gelatine capsule containing neutron-activated (153)Sm-labelled resin beads for use in gastrointestinal motility studies. In vitro test in simulated gastrointestinal environment and in vivo study on volunteers were performed. Scintigraphic images were acquired from ten volunteers over 24h while blood and urine samples were collected to monitor the presence of (153)Sm. All the capsules remained intact in stomach. This proved to be a safe and practical oral capsule formulation for whole gut transit scintigraphy.
authors.affiliation: University of Malaya Research Imaging Centre, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Chai-Hong
authors.initials: CH
authors.lastname: Yeong
authors.forename: Basri Johan Jeet
authors.initials: BJ
authors.lastname: Abdullah
authors.forename: Kwan-Hoong
authors.initials: KH
authors.lastname: Ng
authors.forename: Lip-Yong
authors.initials: LY
authors.lastname: Chung
authors.forename: Khean-Lee
authors.initials: KL
authors.lastname: Goh
authors.forename: Sazilah Ahmad
authors.initials: SA
authors.lastname: Sarji
authors.forename: Alan Christopher
authors.initials: AC
authors.lastname: Perkins
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007475:Ion Exchange Resins; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes / Q000737:chemistry*; D011877:Radionuclide Imaging; D012493:Samarium / Q000737:chemistry*
chemical_list: D007475:Ion Exchange Resins; D011868:Radioisotopes; D012493:Samarium