title: Antithrombotic phenolic compounds from Glycyrrhiza uralensis.
abstract: A new coumestan, named glycyrurol, and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative assay found significant antithrombotic activity of compounds 4, 8 and 10.
authors.affiliation: School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tao
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Meng-Zhu
authors.initials: MZ
authors.lastname: Liu
authors.forename: Ye-Fei
authors.initials: YF
authors.lastname: Qian
mesh_terms: D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D006576:Heterocyclic Compounds, 4 or More Rings; D010636:Phenols; D010936:Plant Extracts; C505898:coumestan