title: [The role of pattern-recognizing receptors in anti-infectious immunity].
abstract: Pattern-recognizing receptors (PRR) play a key role in the functioning of human immune system. They are the primary sensors of infection capable of distinguishing between various highly conservative molecular patterns (pathogen-associated molecular patterns (PAMPs)) contained in pathogenic organisms. Binding of these molecular patterns to PRR induces a variety of reactions of innate (secretion of proinflammatory cytokines and antimicrobial peptides, activation of phagocytosis, etc.) and adaptive (antibody processing and presentation, polarization of T-cell response, etc.) immunity. Great interest in the molecular mechanisms of pathogen recognition resulted in the discovery of numerous PRR. The aim of this review is to systematize the currently available data on PRR, their specificity, and role in the formation of anti-inflammatory immunity.
authors.forename: A I
authors.initials: AI
authors.lastname: Tukhvatulin
authors.forename: D N
authors.initials: DN
authors.lastname: Shcherbinin
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Logunov
authors.forename: M M
authors.initials: MM
authors.lastname: Shmarov
authors.forename: B S
authors.initials: BS
authors.lastname: Naroditskiĭ
mesh_terms: D017951:Antigen Presentation; D003141:Communicable Diseases / Q000188:drug therapy / Q000276:immunology*; D005544:Forecasting; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D008024:Ligands; D051192:Receptors, Pattern Recognition / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008024:Ligands; D051192:Receptors, Pattern Recognition