title: Serum galactomannan and (1->3)-β-D-glucan assays for patients with multiple myeloma and Waldenstrom's macroglobulinemia.
abstract: We assessed the performance of galactomannan and (1→3)-β-d-glucan in 29 serum samples from patients with multiple myeloma and Waldenstrom's macroglobulinemia without invasive fungal disease to address issues of false positivity and uninterpretable results previously reported among patients with these conditions. Galactomannan and (1→3)-β-d-glucan assays were not falsely elevated in any patient. (1→3)-β-d-glucan assay results were uninterpretable in 24% of patients. Patients with IgG levels of >2,000 mg/dl had higher odds of uninterpretable (1→3)-β-d-glucan results.
authors.affiliation: Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA. nissa@partners.org
authors.forename: Nicolas C
authors.initials: NC
authors.lastname: Issa
authors.forename: Sophia
authors.initials: S
authors.lastname: Koo
authors.forename: Robert C
authors.initials: RC
authors.lastname: Lynch
authors.forename: Charline
authors.initials: C
authors.lastname: Gay
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Hammond
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Baden
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Finkelman
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Marty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003951:Diagnostic Errors; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008351:Mannans / Q000097:blood*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D009181:Mycoses / Q000175:diagnosis*; D011509:Proteoglycans; D044967:Serum / Q000737:chemistry; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology; D047071:beta-Glucans / Q000097:blood*
chemical_list: D008351:Mannans; D011509:Proteoglycans; D047071:beta-Glucans; C012990:galactomannan; C010770:polysaccharide-K; D005690:Galactose