title: NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates.
abstract: Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase bla(NDM) gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the bla(NDM-2) gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the bla(NDM-2) gene showed significant similarities with those associated with bla(NDM-1) in Enterobacteriaceae and A. baumannii. Repeated isolation of bla(NDM-2)-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
authors.forename: A
authors.initials: A
authors.lastname: Ghazawi
authors.forename: A
authors.initials: A
authors.lastname: Sonnevend
authors.forename: R A
authors.initials: RA
authors.lastname: Bonnin
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
authors.forename: R
authors.initials: R
authors.lastname: Hashmey
authors.forename: T A
authors.initials: TA
authors.lastname: Rizvi
authors.forename: M
authors.initials: M
authors.lastname: B Hamadeh
authors.forename: T
authors.initials: T
authors.lastname: Pál
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D058889:Molecular Typing; D009369:Neoplasms / Q000150:complications; D017422:Sequence Analysis, DNA; D014479:United Arab Emirates; D014556:Urine / Q000382:microbiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases; C063912:carbapenemase