title: [Effective glucocorticoid treatment in a case of idiopathic fibrosing mediastinitis].
abstract: A 54-year-old man was admitted to Saga University hospital with dyspnea on effort and a sensation of pressure in the chest. Chest CT images showed a low-density mass in the mediastinum surrounding the carina and left hilus, causing narrowing of both the left pulmonary artery and left main bronchus. The pathological findings from a surgical biopsy showed markedly fibrotic tissue with lymphocytes and plasmacytes, and we diagnosed idiopathic fibrosing mediastinitis, stage II. Oral glucocorticoid treatment of 30 mg/day prednisolone reduced the mass and improved the narrowing of the left pulmonary artery and left main bronchus. The patient was given low-dosage glucocorticoids as maintenance treatment. Previous reports indicated that idiopathic fibrosing mediastinitis with severe tissue fibrosis is difficult to control with glucocorticoid monotherapy. Here, we report a case of idiopathic fibrosing mediastinitis that was effectively treated with glucocorticoids.
authors.affiliation: Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University.
authors.forename: Go
authors.initials: G
authors.lastname: Kato
authors.forename: Koichiro
authors.initials: K
authors.lastname: Takahashi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Abe
authors.forename: Chiho
authors.initials: C
authors.lastname: Kakino
authors.forename: Ayako
authors.initials: A
authors.lastname: Matsuo
authors.forename: Naomi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Komiya
authors.forename: Naoko
authors.initials: N
authors.lastname: Sueoka-Aragane
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008480:Mediastinitis / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone