title: [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
abstract: Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
authors.affiliation: Institut de médecine sociale et préventive, CHUV, Route de la Corniche 2, 1066 Epalinges. Murielle.Bochud@chuv.ch
authors.forename: M
authors.initials: M
authors.lastname: Bochud
authors.forename: P
authors.initials: P
authors.lastname: Vollenweider
authors.forename: G
authors.initials: G
authors.lastname: Waeber
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000401:mortality; D015331:Cohort Studies; D051246:Glucose Transport Proteins, Facilitative / Q000097:blood*; D006073:Gout / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D013557:Switzerland / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human; D014527:Uric Acid