title: Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts.
abstract: Bone mineral density (BMD) and bone strength are predictive parameters for the development of osteoporosis and related fracture later in life. Although it is well known that BMD and bone strength have a high heritability, not much of the variation is already explained. Mice models showed that sFRP1 has an influence on bone formation. Therefore this study aimed to investigate the effect of common genetic variation on BMD and bone strength in Caucasian men of different ages. Using HapMap we selected 13 tagSNPs which tag most common genetic variation in and around sFRP1 and we genotyped these SNPs in the young cohort of the Odense Androgen Study (OAS). The OAS includes a total of 1383 Danish men from two different age groups ([20-29 years]: N=783; [60-74 years]: N=600) and is well characterised. The subjects were phenotyped for BMD at several sites, and additionally for body composition and hip geometry parameters. Based on the results of the young cohort we selected three SNPs for further analysis in the complete OAS population. To conclude we tried to replicate the results of two SNPs in an independent population of 994 Belgian men. We found a strong association for rs9694405 with BMI as well in both cohorts separately as in the whole OAS population. Further we found rs4736965 associated with several hip geometry parameters in the same population. However we were not able to replicate those results in the Belgian population. At last we found in the OAS population age specific effects for rs10106678 with whole body BMD and waist to hip ratio.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Belgium. eveline.boudin@ua.ac.be
authors.forename: Eveline
authors.initials: E
authors.lastname: Boudin
authors.forename: Elke
authors.initials: E
authors.lastname: Piters
authors.forename: Erik
authors.initials: E
authors.lastname: Fransen
authors.forename: Torben Leo
authors.initials: TL
authors.lastname: Nielsen
authors.forename: Marianne
authors.initials: M
authors.lastname: Andersen
authors.forename: Greet
authors.initials: G
authors.lastname: Roef
authors.forename: Youri
authors.initials: Y
authors.lastname: Taes
authors.forename: Kim
authors.initials: K
authors.lastname: Brixen
authors.forename: Wim
authors.initials: W
authors.lastname: Van Hul
mesh_terms: D050154:Adiposity / Q000235:genetics; D000328:Adult; D000368:Aged; D001530:Belgium; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000502:physiology*; D015331:Cohort Studies; D003718:Denmark; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics; D055815:Young Adult; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins