title: Self-similar dynamics of morphogen gradients.
abstract: Morphogen gradients are concentration fields of molecules acting as spatial regulators of cell differentiation in developing tissues and play a fundamental role in various aspects of embryonic development. We discovered a family of self-similar solutions in a canonical class of nonlinear reaction-diffusion models describing the formation of morphogen gradients. These solutions are realized in the limit of infinitely high production rate at the tissue boundary and are given by the product of the steady state concentration profile and a function of the diffusion similarity variable. We solved the boundary value problem for the similarity profile numerically and analyzed the implications of the discovered self-similarity on the dynamics of morphogenetic patterning.
authors.affiliation: Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102, USA.
authors.forename: Cyrill B
authors.initials: CB
authors.lastname: Muratov
authors.forename: Peter V
authors.initials: PV
authors.lastname: Gordon
authors.forename: Stanislav Y
authors.initials: SY
authors.lastname: Shvartsman
mesh_terms: D003198:Computer Simulation; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins