title: Extraskeletal osteosarcoma: spectrum of imaging findings.
abstract: OBJECTIVE
  The purpose of this article is to present the spectrum of imaging findings of primary and metastatic extraskeletal osteosarcoma and highlight the differences from primary osteogenic osteosarcoma in bone.
  
  
  CONCLUSIONS
  Extraskeletal osteosarcoma is a rare mesenchymal malignancy of soft tissue, histologically indistinguishable from primary osteosarcoma of bone. However, there are distinct differences in demographics, imaging features, prognosis, and management compared with osteogenic osteosarcoma. Imaging characteristics reflect tumor morphology, with only 50% of primary tumors showing mineralization. Metastases may or may not show mineralization, even if present in the primary tumor. The overall prognosis is poor.
authors.affiliation: Department of Radiology, Dana-Farber Cancer Institute, Harvard Medical School, and Department of Pathology, Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215-5450, USA. grainnemcauley@mac.com
authors.forename: Grainne
authors.initials: G
authors.lastname: Mc Auley
authors.forename: Jyothi
authors.initials: J
authors.lastname: Jagannathan
authors.forename: Kevin
authors.initials: K
authors.lastname: O'Regan
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Krajewski
authors.forename: Jason L
authors.initials: JL
authors.lastname: Hornick
authors.forename: James
authors.initials: J
authors.lastname: Butrynski
authors.forename: Nikhil
authors.initials: N
authors.lastname: Ramaiya
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D019275:Radiopharmaceuticals; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals