title: Pregnancy-induced Cushing's syndrome in recurrent pregnancies: case report and literature review.
abstract: Pregnancy in women with Cushing's syndrome (CS) is uncommon. It is associated with significant maternal and fetal complications. Pregnancy-induced Cushing's syndrome is exceptionally rare with fewer than ten cases reported in the world literature and none in Australia or New Zealand. We describe a woman with possible recurrent pregnancy-induced CS complicating five pregnancies over a 7-year period. We discuss the changes in the hypothalamic-pituitary-adrenal axis during normal pregnancy together with the diagnosis, aetiology and management of CS in pregnancy.
authors.affiliation: Royal Brisbane and Women's Hospital, Herston, Qld, Australia. naomi_achong@health.qld.gov.au
authors.forename: Naomi
authors.initials: N
authors.lastname: Achong
authors.forename: Michael
authors.initials: M
authors.lastname: D'Emden
authors.forename: Narelle
authors.initials: N
authors.lastname: Fagermo
authors.forename: Robin
authors.initials: R
authors.lastname: Mortimer
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001315:Australia; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008797:Metyrapone / Q000627:therapeutic use*; D009520:New Zealand; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D004791:Enzyme Inhibitors; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D008797:Metyrapone