title: Genomically humanized mice: technologies and promises.
abstract: Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.
authors.affiliation: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London                 WC1N 3BG, UK.
authors.forename: Anny
authors.initials: A
authors.lastname: Devoy
authors.forename: Rosie K A
authors.initials: RK
authors.lastname: Bunton-Stasyshyn
authors.forename: Victor L J
authors.initials: VL
authors.lastname: Tybulewicz
authors.forename: Andrew J H
authors.initials: AJ
authors.lastname: Smith
authors.forename: Elizabeth M C
authors.initials: EM
authors.lastname: Fisher
mesh_terms: D000818:Animals; D022221:Chromosomes, Artificial, Mammalian / Q000235:genetics*; D004195:Disease Models, Animal; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D030342:Genetic Diseases, Inborn / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011995:Recombination, Genetic; D050436:Regulatory Elements, Transcriptional; D019076:Transgenes / Q000235:genetics*