title: Effect of Helicobacter pylori Eradication on the Development of Reflux Esophagitis and Gastroesophageal Reflux Symptoms: A Nationwide Multi-Center Prospective Study.
abstract: OBJECTIVE
  A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population.
  
  
  METHODS
  In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms.
  
  
  RESULTS
  RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% CI, 1.03 to 19.19) and F/U cholesterol levels ≥200 mg/dL (OR, 5.03; 95% CI, 1.32 to 19.17) were significant risk factors for the development of RE. There was no significant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U.
  
  
  CONCLUSIONS
  Eradication of H. pylori did not affect the development of reflux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea.
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Gwang Ho
authors.initials: GH
authors.lastname: Baik
authors.forename: Sung Jung
authors.initials: SJ
authors.lastname: Kim
authors.forename: Geom Seog
authors.initials: GS
authors.lastname: Seo
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Oh
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Heyjin
authors.initials: H
authors.lastname: Jeong
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Hong
authors.forename: Ki-Nam
authors.initials: KN
authors.lastname: Shim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Seun Ja
authors.initials: SJ
authors.lastname: Park
authors.forename: Eui Hyeog
authors.initials: EH
authors.lastname: Im
authors.forename: Jong-Jae
authors.initials: JJ
authors.lastname: Park
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Cho
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung