title: [Risk factors for infection with extended-spectrum beta-lactamase-producing strains in children].
abstract: OBJECTIVE
  To study the risk factors for infection with extended-spectrum beta-lactamase (ESBL) producing strains in children.
  
  
  METHODS
  The clinical data of 242 pediatric in-patients with lower respiratory tract infections from February 2009 to January 2011 were retrospectively analyzed. The risk factors of ESBL-producing strain infections were investigated using univariate analysis and multivariate logistic regression analysis.
  
  
  RESULTS
  Univariate analysis showed that six factors were related with ESBL-producing strain infections: repeated sucking of phlegm (OR: 2.279, P<0.01), tracheal intubation(OR: 3.101, P<0.01), administration of the third generation cephalosporin for more than three days (OR: 3.628, P<0.01), admission to the pediatric intensive care unit (PICU) (OR: 2.378, P<0.01), indwelling of nasogastric tube (OR: 2.460, P<0.01), prophylactic use of antibiotics (OR: 1.747, P<0.05). Multivariate logistic regression showed that the application of the third-generation cephalosporin for more than three days (OR: 5.672, P<0.01), repeated sucking of phlegm (OR: 3.917, P<0.01), tracheal intubation (OR: 3.717, P<0.01), indwelling of nasogastric tube (OR: 2.961, P<0.01), and admission to PICU (OR: 3.237, P<0.01) were the independent risk factors for the infections.
  
  
  CONCLUSIONS
  The infections of ESBL-producing strains are caused by many factors, among which the application of the third-generation cephalosporin for more than three days, invasive operations, and admission to PICU are the independent risk factors.
authors.affiliation: Children's Hospital of Hebei Province, Shijiazhuang 050031, China. liujianhua@sina.com
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Xin-Feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Shuai
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001618:beta-Lactamases