title: Exceptionally high titres in atypical presentation of occult epididymo-orchitis due to brucellosis.
abstract: A male patient of 32 years was referred for surgical drainage and orchidectomy of the right testis following a cycling injury. A Venereal Disease Research Laboratory (VDRL) test was requested by the surgery department to rule out secondary syphilis. Although serum samples gave a negative result in the VDRL test, qualitative screening was performed for Brucella antibodies, as per hospital policy, since brucellosis is endemic in this region. Following a positive reaction, a quantitative standard tube agglutination test was carried out yielding titres that were exceptionally high (STAT = 40 960 IU ml(-1); 2-ME = 1 : 5120). This finding correlated with the patient's history which included a number of predisposing factors for contracting brucellosis including exposure to cattle, consumption of raw milk and assisting in the parturition of cattle. Consequently, surgery was postponed and treatment was changed from injections of ceftriaxone to the WHO regimen for the treatment of brucellosis: 1 g streptomycin once daily, administered intra-muscularly, plus 100 mg doxycycline twice daily, taken orally. Following 3 days of this treatment, the testicular swelling reduced considerably and orchidectomy was not required. Indeed, after a week, swelling was completely resolved and the patient was discharged. To our knowledge, this is the first case of such high titres in a patient as a result of epididymo-orchitis without the typical clinical presentation of fever and joint pain that is normally associated with brucellosis.
authors.affiliation: KLE Charitable Hospital and Medical Research Center, KLE University, Belgaum, Karnataka, India.|Department of Microbiology, Jawaharlal Nehru Medical College, Nehru nagar, Belgaum 590010, Karnataka, India.
authors.forename: Shashank
authors.initials: S
authors.lastname: Purwar
authors.affiliation: Department of Microbiology, Jawaharlal Nehru Medical College, Nehru nagar, Belgaum 590010, Karnataka, India.
authors.forename: S C
authors.initials: SC
authors.lastname: Metgud
authors.affiliation: Department of Microbiology, Jawaharlal Nehru Medical College, Nehru nagar, Belgaum 590010, Karnataka, India.
authors.forename: Shilpa K
authors.initials: SK
authors.lastname: Gokale
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000907:Antibodies, Bacterial / Q000097:blood; D002002:Brucella / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D002417:Cattle; D019411:Clinical Laboratory Techniques / Q000379:methods; D004318:Doxycycline / Q000008:administration & dosage; D004823:Epididymitis / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D009920:Orchitis / Q000150:complications* / Q000382:microbiology; D013307:Streptomycin / Q000008:administration & dosage; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004318:Doxycycline; D013307:Streptomycin