title: Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats.
abstract: The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose, HbA1(c), urea, creatinine, AST, ALT, and lipid profiles with a concomitant decrease in total hemoglobin, plasma glutathione and vitamin C as compared to the control group. The treatment with SMV at a dose (10 mg/kg, orally) normalized all the above-mentioned biochemical parameters in STZ-induced diabetic rats. In vitro studies confirmed the free radical scavenging and antioxidant activity of SMV. Therefore, the present results revealed that SMV has a protective effect against STZ-induced oxidative damage by scavenging the free radicals generation and restoring the enzymatic and nonenzymatic antioxidant systems.
authors.affiliation: Department of Chemistry for Health Sciences, Deanery of Academic Services, Health Sciences Track, Taibah University, Al-Madinah, Saudi Arabia.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Mohamadin
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Elberry
authors.forename: Hala S
authors.initials: HS
authors.lastname: Abdel Gawad
authors.forename: Gehan M
authors.initials: GM
authors.lastname: Morsy
authors.forename: Fahad A
authors.initials: FA
authors.lastname: Al-Abbasi