title: Serum levels of soluble CD26 and CD30 and their clinical significance in patients with rheumatoid arthritis.
abstract: The aim of this study was to assess serum levels and clinical significance of soluble CD26 (sCD26) and soluble CD30 (sCD30) in patients with rheumatoid arthritis (RA). Forty-eight patients with RA and 30 healthy controls were enrolled. Serum sCD26 and sCD30 levels were measured using ELISA. Serum sCD26 levels were significantly lower (P = 0.011), whereas sCD30 levels were higher (P = 0.008) in patients with RA than controls. Serum levels of sCD30 correlated significantly with clinical and laboratory parameters of disease activity like erythrocyte sedimentation rate, C-reactive protein, disease activity scores-28 and health assessment questionnaire score; however, sCD26 levels did not correlate any of these activity parameters. These results suggest that serum sCD30 levels increased and correlated significantly with disease activity, indicating a novel follow-up parameter in RA. Serum levels of sCD26 may be lessen but not related to disease activity in RA.
authors.affiliation: Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, Elazig, Turkey. ulusoyh@mynet.com
authors.forename: Hasan
authors.initials: H
authors.lastname: Ulusoy
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kamanli
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.forename: Omer
authors.initials: O
authors.lastname: Kuru
authors.forename: Sule
authors.initials: S
authors.lastname: Arslan
authors.forename: Gokhan
authors.initials: G
authors.lastname: Alkan
authors.forename: Salih
authors.initials: S
authors.lastname: Ozgocmen
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D017730:Ki-1 Antigen; D018819:Dipeptidyl Peptidase 4