title: [Pathogenicity factors of bacteria with glycosylating activity].
abstract: A and B toxins of Clostridium difficile, a-toxin of C. novyi, lehal toxin of C. sordellii, and TpeL toxin of C. perfringens belong to the group of the so-called large Clostridium toxins. These toxins modify low-molecular weight guanosine triphosphate-binding proteins of the Rho/Ras family by their glycosylation that results in inactivation of major signal pathways in eukaryotic cells. Lgt glycosyltransferases, a new group of pathogenicity factors also capable of inactivating eukaryotic substrates via glycosylation, have recently been identified in Legionella. They are transported into cytoplasm of eukaryotic target cells by type 4 secretory system of Legionella. After translocation, the enzyme inhibits protein synthesis by attaching glucose residue to Ser53 of 1A elongation factor. The available data suggest an important role of bacterial glycosylating factors in the action of pathogens causing infectious diseases.
authors.forename: D I
authors.initials: DI
authors.lastname: Tartakovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Araslanova
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Belyĭ
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology; D001426:Bacterial Proteins / Q000378:metabolism*; D003013:Clostridium / Q000145:classification / Q000378:metabolism* / Q000472:pathogenicity; D005057:Eukaryotic Cells / Q000378:metabolism / Q000382:microbiology; D006031:Glycosylation; D006801:Humans; D007875:Legionella / Q000378:metabolism* / Q000472:pathogenicity; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D013379:Substrate Specificity; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors