title: Anticancer activity of some bisbenzimidazoles.
abstract: The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bisbenzimidazole derivatives are important compounds known as DNA topoisomerase I inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity. Anticancer activity screening was applied on HT-29 (colon carcinoma) and MCF-7 (breast carcinoma) cell lines by investigation of cytotoxicity, analysis of DNA synthesis, and DNA fragmentation assays. One of the seven compounds tested showed significant cytotoxicity in both cell lines and caused DNA degradation in the HT-29 cell line.
authors.affiliation: Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Işikdağ
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozkay
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Incesu
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akalin
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002853:Chromatography, Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles