title: Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
abstract: The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Torres
authors.forename: María D
authors.initials: MD
authors.lastname: Duque
authors.forename: Marta
authors.initials: M
authors.lastname: López-Querol
authors.forename: Martin C
authors.initials: MC
authors.lastname: Taylor
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Chunlong
authors.initials: C
authors.lastname: Ma
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Pinto
authors.forename: Francesc X
authors.initials: FX
authors.lastname: Sureda
authors.forename: John M
authors.initials: JM
authors.lastname: Kelly
authors.forename: Santiago
authors.initials: S
authors.lastname: Vázquez
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004267:DNA Viruses / Q000187:drug effects*; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
chemical_list: D000588:Amines; D000998:Antiviral Agents; D016194:Receptors, N-Methyl-D-Aspartate; D014344:Trypanocidal Agents