title: Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities.
abstract: OBJECTIVE
  To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).
  
  
  METHODS
  Phenotypic and mutational study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.
  
  
  METHODS
  Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.
  
  
  METHODS
  Not applicable.
  
  
  RESULTS
  The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).
  
  
  CONCLUSIONS
  The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, People's Republic of China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Dang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.forename: Yulan
authors.initials: Y
authors.lastname: Mu
authors.forename: Guangyu
authors.initials: G
authors.lastname: Li
authors.forename: Mingdi
authors.initials: M
authors.lastname: Xia
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006785:Hospitals, University; D006801:Humans; D009095:Mullerian Ducts / Q000002:abnormalities*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D014564:Urogenital Abnormalities / Q000208:ethnology / Q000235:genetics*; D051153:Wnt Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: C092778:WNT7A protein, human; D051153:Wnt Proteins