title: Interplay between modifications of chromatin and meiotic recombination hotspots.
abstract: Meiotic recombination lies at the heart of sexual reproduction. It is essential for producing viable gametes with a normal haploid genomic content and its dysfunctions can be at the source of aneuploidies, such as the Down syndrome, or many genetic disorders. Meiotic recombination also generates genetic diversity that is transmitted to progeny by shuffling maternal and paternal alleles along chromosomes. Recombination takes place at non-random chromosomal sites called 'hotspots'. Recent evidence has shown that their location is influenced by properties of chromatin. In addition, many studies in somatic cells have highlighted the need for changes in chromatin dynamics to allow the process of recombination. In this review, we discuss how changes in the chromatin landscape may influence the recombination map, and reciprocally, how recombination events may lead to epigenetic modifications at sites of recombination, which could be transmitted to progeny.
authors.affiliation: Institut Curie, Centre de Recherche, Paris, France.
authors.forename: Elsa
authors.initials: E
authors.lastname: Brachet
authors.forename: Vérane
authors.initials: V
authors.lastname: Sommermeyer
authors.forename: Valérie
authors.initials: V
authors.lastname: Borde
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D000782:Aneuploidy; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics; D044127:Epigenesis, Genetic; D005260:Female; D015894:Genome, Human; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics*; D046912:Multiprotein Complexes / Q000235:genetics; D000097722:Cohesins
chemical_list: D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D006657:Histones; D046912:Multiprotein Complexes; D000097722:Cohesins; C108312:condensin complexes