title: Stable IL-10: a new therapeutic that promotes tumor immunity.
abstract: In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-γ secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth. This approach may enhance T cell immune responses in cancers with reduced T cell infiltration.
authors.affiliation: Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.
authors.forename: Michele W L
authors.initials: MW
authors.lastname: Teng
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth