title: Acid-base and electrolyte status during early induced pregnancy toxaemia in goats.
abstract: Eleven Murciano-Granadina goats in late pregnancy were separated into two groups (1) control (n=6) and (2) fasting for 72 h to induce pregnancy toxaemia (n=5). Venous blood was taken daily to determine acid-base and electrolyte parameters. Significant decreases in blood pH, bicarbonate concentration and base excess, and a significant increase in anion gap were observed after 24h of fasting. These changes were significantly correlated with non-esterified fatty acid concentration. No significant changes were observed in pCO(2), and electrolyte or lactate concentrations. Clinical signs of pregnancy toxaemia in fasted goats appeared by 72h post-fasting. These signs and the changes in acid-base balance disappeared once feed was reintroduced. Blood pH, bicarbonate concentration, base excess and anion gap could be indicators of early pregnancy toxaemia in goats.
authors.affiliation: Veterinary School, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Brazil.
authors.forename: Félix H Díaz
authors.initials: FH
authors.lastname: González
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Hernández
authors.forename: Josefa
authors.initials: J
authors.lastname: Madrid
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: José Joaquín
authors.initials: JJ
authors.lastname: Cerón
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
mesh_terms: D000136:Acid-Base Equilibrium; D000137:Acid-Base Imbalance / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D005260:Female; D015511:Goat Diseases / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D006041:Goats; D006863:Hydrogen-Ion Concentration; D011247:Pregnancy; D011897:Random Allocation; D014115:Toxemia / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000662:veterinary*; D014883:Water-Electrolyte Imbalance / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D001639:Bicarbonates