title: [Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature].
abstract: OBJECTIVE
  To study the association between single nucleotide polymorphism (SNP) of insulin-like growth factor I receptor (IGF-IR) gene and idiopathic short stature (ISS).
  
  
  METHODS
  A total of 804 children with ISS and 575 normal controls were recruited from 2008 to 2011. IGF-IR gene SNP was genotyped using the Snapshot Multiplex System.
  
  
  RESULTS
  The distribution frequency of genotype rs1976667 showed no significant difference between the ISS and the control groups, while that of the allele A of rs1976667 was significantly higher in the ISS group than in the control group (P<0.01).
  
  
  CONCLUSIONS
  The allele A at rs1976667 SNP of IGF-IR gene is a risk factor for ISS.
authors.affiliation: Department of Endocrinology, Children's Hospital of Jiangxi Province, Nanchang 330006, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Xie
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017526:Receptor, IGF Type 1 / Q000235:genetics*
chemical_list: D017526:Receptor, IGF Type 1