title: [Relationship between alanine aminotransferase and overweight or obesity in children].
abstract: OBJECTIVE
  To study the association of alanine aminotransferase (ALT) with overweight or obesity in children.
  
  
  METHODS
  A total of 2889 healthy children and 702 overweight or obese children aged from 7 to 18 years who had received a physical examination were enrolled. Height, body weight, waist circumference, and blood pressure were measured, and the biochemical indicators including blood glucose, blood lipids, ALT, and insulin were detected. The insulin resistance index were calculated.
  
  
  RESULTS
  The ALT level was significantly higher in boys than in girls. Along with the increase of BMI, the ALT level increased in the normal, overweight, and obese groups in both boys and girls. ALT was correlated with BMI, waist circumference, triglyceride, and insulin resistance index. Among the overweight or obese children, the boys with the increased ALT level had higher BMI, waist circumference, blood pressure, triglyceride, low density lipoprotein and insulin resistance index than the boys with normal ALT level (P<0.05); the girls with the increased ALT level had higher waist circumference, blood pressure and insulin resistance index and lower high density lipoprotein than the girls with normal ALT level (P<0.05).
  
  
  CONCLUSIONS
  ALT is correlated with overweight and obesity and metabolic disorders caused by overweight and obesity such as dyslipidemia and insulin resistance.
authors.affiliation: Department of Pediatrics, Maternity and Child Care Center of Guangxi, Nanning 530003, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fan
authors.forename: Shao-Ke
authors.initials: SK
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Tang
authors.forename: Jing-Si
authors.initials: JS
authors.lastname: Luo
authors.forename: Ying
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000201:enzymology*; D050177:Overweight / Q000201:enzymology*
chemical_list: D000410:Alanine Transaminase