title: [A rare cause of febrile polyadenopathy in children: Kikuchi-Fujimoto disease].
abstract: Kikuchi disease is a histiocytic necrotizing lymphadenitis revealed by cervical lymphadenopathy and prolonged fever. It occurs predominantly in young Asian women. The pathophysiology is unknown; the main hypothesis is an autoimmune process. Although the disease usually resolves spontaneously in a few weeks or months, it may progress to systemic lupus erythematosus. Kikuchi disease is rare in children, but it should be considered a potential diagnosis in case of polyadenopathy. We relate a case of Kikuchi-Fujimoto disease in a 13-year-old boy with sickle-cell anemia. The diagnosis, which was established after 3 weeks of hospitalization, enabled us to avoid unnecessary extensive investigations and prolonged empirical treatments that may result in unintended adverse side effects.
authors.affiliation: Service de pédiatrie, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France. celmarrec@yahoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Marrec
authors.forename: G
authors.initials: G
authors.lastname: Picherot
authors.forename: C
authors.initials: C
authors.lastname: Kandel
authors.forename: M
authors.initials: M
authors.lastname: Caquard
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005334:Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal