title: Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease.
abstract: OBJECTIVE
  We hypothesised that nonadherence to thiopurines is more common in adolescents than in adults with inflammatory bowel disease.
  
  
  METHODS
  We sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels.
  
  
  RESULTS
  Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence interval [CI] 1.9-11.5]; P < 0.01) compared with adults, patients with Crohn disease (OR 3.3 [CI 1.1-10.5] P = 0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 [CI 1.0-1.1] P = 0.02) were more likely to be nonadherent to thiopurines.
  
  
  CONCLUSIONS
  Adolescents are more frequently nonadherent than adults: prospective studies are required to determine the reasons for nonadherence in adolescents.
authors.affiliation: Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary's University, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Kamperidis
authors.forename: J R
authors.initials: JR
authors.lastname: Goodhand
authors.forename: F A
authors.initials: FA
authors.lastname: Chowdhury
authors.forename: Y
authors.initials: Y
authors.lastname: Koodun
authors.forename: N C
authors.initials: NC
authors.lastname: Direzke
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: I R
authors.initials: IR
authors.lastname: Sanderson
authors.forename: N M
authors.initials: NM
authors.lastname: Croft
authors.forename: F L
authors.initials: FL
authors.lastname: Langmead
authors.forename: P M
authors.initials: PM
authors.lastname: Irving
authors.forename: D S
authors.initials: DS
authors.lastname: Rampton
authors.forename: J O
authors.initials: JO
authors.lastname: Lindsay
mesh_terms: D000293:Adolescent; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016001:Confidence Intervals; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D055118:Medication Adherence; D015122:Mercaptopurine / Q000008:administration & dosage*; D015999:Multivariate Analysis; D016017:Odds Ratio; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015122:Mercaptopurine