title: Association between circulating angiotensin-converting enzyme and exercise-induced pulmonary haemorrhage in Thoroughbred racehorses.
abstract: Exercise-induced pulmonary haemorrhage has an impact on racehorse performance. Although endoscopic diagnosis (with or without the aid of bronchoalveolar lavage) is considered to be the standard diagnostic method for this condition, the use of biomarkers that could aid in quantifying risk and severity of the condition would represent an advance in equine sport medicine. This preliminary research investigated the use of angiotensin-converting enzyme (ACE) activity in plasma of racehorses and demonstrated that ACE activity is increased in horses with higher degrees of haemorrhage and is a promising biomarker for EIPH in racehorses.
authors.affiliation: The University of Melbourne, Faculty of Veterinary Science, 250 Princes Highway, Werribee 3030, Australia. mfveterinaria@ig.com.br
authors.forename: M F M
authors.initials: MF
authors.lastname: Costa
authors.forename: F A
authors.initials: FA
authors.lastname: Ronchi
authors.forename: A
authors.initials: A
authors.lastname: Ivanow
authors.forename: A K
authors.initials: AK
authors.lastname: Carmona
authors.forename: D
authors.initials: D
authors.lastname: Casarini
authors.forename: R F
authors.initials: RF
authors.lastname: Slocombe
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D006470:Hemorrhage / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood* / Q000378:metabolism; D006736:Horses; D008171:Lung Diseases / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000378:metabolism; D010805:Physical Conditioning, Animal
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A