title: [Research advances of multiple myeloma immunophenotyping].
abstract: Multiple myeloma (MM) is a clonal B-cell disorder in which malignant plasma cells (PC) accumulate in the bone marrow and produce lytic bone lesions and excessive amounts of monoclonal immunoglobulin. The diagnosis of MM requires the examination of bone marrow, showing PC infiltration, detection and quantification of monoclonal immunoglobulin in the serum or urine and evidence of organ damage (hypercalcemia, renal insufficiency, anaemia or bone lesions). This review discusses the significance of immunotyping for diagnosis and prognosis of MM.
authors.affiliation: Department of Hematology, Guangzhou General Hospital, Guangdong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Pang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Kuang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D009101:Multiple Myeloma / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis