title: Estimated glomerular filtration rate decline in 567 patients with acute stroke.
abstract: OBJECTIVE
  Chronic kidney disease, characterized by a decline in renal function, is a public health challenge, affecting around 10% of the population worldwide. The aim of this study was to investigate the prevalence of decline in renal function in patients admitted for acute first-ever stroke from a local centre in China, and its impact on mortality and neurological impairment during a short follow-up period.
  
  
  METHODS
  In total, 640 patients hospitalized due to acute stroke were enrolled in this prospective study. Clinical data were obtained and a 3-month follow-up was executed by a team of trained investigators. The data indicated that the prevalence of estimated glomerular filtration rate (eGFR) decline (≤60 ml/min/1.73 m(2)) was 18.5% in this specific population.
  
  
  RESULTS
  Hyperuricaemia, elevated homocysteine and smoking history were identified as three major risk factors associated with eGFR decline. An eGFR ≤60 ml/min/1.73 m(2) was detected in 45.1% of haemorrhagic stroke patients, while 14.7% of ischaemic stroke patients had an accompanying eGFR decline. During the follow-up period, the mortality rate was 18.1% in patients with eGFR decline and 1.5% in patients with eGFR >60 ml/min/1.73 m(2).
  
  
  CONCLUSIONS
  This study clearly shows that the prevalence of renal impairment is high in acute stroke patients in China, and renal impairment may confer a significant risk for worse outcomes such as impaired neurological function and death, at least in the short term.
authors.affiliation: Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin, China. liudiange@yahoo.com
authors.forename: Diange
authors.initials: D
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
authors.forename: Shaohua
authors.initials: S
authors.lastname: Liu
authors.forename: Jingqun
authors.initials: J
authors.lastname: Shen
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D005919:Glomerular Filtration Rate; D006710:Homocysteine / Q000097:blood; D006801:Humans; D033461:Hyperuricemia / Q000150:complications; D020300:Intracranial Hemorrhages / Q000150:complications; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000209:etiology; D012907:Smoking / Q000009:adverse effects; D020521:Stroke / Q000150:complications*
chemical_list: D006710:Homocysteine