title: Associations among visceral fat, all-cause mortality, and obesity-related mortality in Japanese Americans.
abstract: OBJECTIVE
  The study objective was to examine the associations among visceral fat (VF), all-cause mortality, and obesity-related mortality.
  
  
  METHODS
  A total of 733 Japanese Americans were followed for 16.9 years. Hazard ratios (HRs) per interquartile range increase in VF were calculated using time-dependent Cox proportional hazard models censored at age 82 years, with age as the time axis adjusted for sex and smoking.
  
  
  RESULTS
  Higher VF was associated with all-cause mortality (HR 1.39 [95% CI 1.11-1.75] 107 deaths) and obesity-related mortality (1.39 [1.04-1.85], 68 deaths from cardiovascular disease, diabetes, or obesity-related cancer). After further adjustment for waist circumference, VF remained significantly associated with all-cause mortality (1.41 [1.04-1.92]) but not with obesity-related mortality. The associations between mortality and VF were not independent of BMI.
  
  
  CONCLUSIONS
  VF was associated with all-cause mortality and obesity-related mortality in Japanese Americans. VF did not significantly improve mortality risk assessment beyond that of BMI.
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington, USA. mcneely@u.washington.edu
authors.forename: Marguerite J
authors.initials: MJ
authors.lastname: McNeely
authors.forename: Jane B
authors.initials: JB
authors.lastname: Shofer
authors.forename: Donna L
authors.initials: DL
authors.lastname: Leonetti
authors.forename: Wilfred Y
authors.initials: WY
authors.lastname: Fujimoto
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Boyko
mesh_terms: D000328:Adult; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data; D002318:Cardiovascular Diseases / Q000401:mortality; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000401:mortality*; D016016:Proportional Hazards Models; D012307:Risk Factors