title: Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome.
abstract: Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndrome (MDS) due to quantitative and qualitative granulocytic defects. We evaluated the in vitro bactericidal and fungicidal activities of neutrophils isolated from MDS. With comparison to those from healthy individuals, MDS neutrophils following infection showed a significantly reduced killing activity against Escherichia coli at 8 (p=0.002), 24 (p<0.0001), 48 (p=0.0005), and 72 h (p=0.0264), against Lactococcus lactis at 24 (p=0.0002), 48 (p<0.0001), and 72 h (p<0.0001), and more against Candida albicans at 8 (p=0.0003), 24 (p<0.0001), 48 (p<0.0001), and 72 h (p<0.0001). Our data show that MDS neutrophils have an impaired microbicidal function, which might account for the high susceptibility to infections of MDS patients.
authors.affiliation: Department of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. luana.fianchi@rm.unicatt.it
authors.forename: Luana
authors.initials: L
authors.lastname: Fianchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
authors.forename: Brunella
authors.initials: B
authors.lastname: Posteraro
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.forename: Francesco
authors.initials: F
authors.lastname: Guidi
authors.forename: Caterina Giovanna
authors.initials: CG
authors.lastname: Valentini
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Voso
authors.forename: Livio
authors.initials: L
authors.lastname: Pagano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001770:Blood Bactericidal Activity; D002176:Candida albicans / Q000276:immunology*; D016022:Case-Control Studies; D002478:Cells, Cultured; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006801:Humans; D013294:Lactococcus lactis / Q000276:immunology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000276:immunology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000276:immunology* / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D011379:Prognosis; D012307:Risk Factors