title: An Epstein-Barr virus-associated leukemic lymphoma in a patient treated with rabbit antithymocyte globulin and cyclosporine for hepatitis-associated aplastic anemia.
abstract: Lymphoproliferative disorders (LPDs) are generally caused by uncontrolled B-cell proliferation induced by the Epstein-Barr virus (EBV) in the setting of impaired EBV-specific T-cell immunity, particularly when there is pharmacological immunosuppression including antithymocyte globulin. We herein present an unusual case of EBV associated with LPD (EBV-LPD) in which LPD occurred 3 weeks after the use of rabbit antithymocyte globulin administered for severe hepatitis-associated aplastic anemia; the patient died of fulminant leukemic lymphoma 5 days after the onset. We also review the pertinent literature on EBV-LPD after immunosuppressive therapy and document the efficacy of EBV viral load monitoring and the need for preemptive therapy.
authors.affiliation: Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan.
authors.forename: Kinya
authors.initials: K
authors.lastname: Ohata
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwaki
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kotani
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kondo
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000821:virology*; D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D019562:Viral Load
chemical_list: D000961:Antilymphocyte Serum; D004279:DNA, Viral; D016572:Cyclosporine