title: Interaction between CYP 2C19*3  polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han  population.
abstract: Cytochrome P450  (CYP) 2C19 metabolizes arachidonic acid to biologically active  epoxyeicosatrienoic acids, which strongly promote proliferation of cancer cells in vitro and in vivo. Knowing that smoking is the most important  risk factor for laryngeal carcinoma, we examined the relationships between  CYP2C19*3 polymorphism, smoking and laryngeal carcinoma in the Chinese Han  population. In a Chinese Han case-control study of 300 laryngeal carcinoma  patients and 300 healthy controls, we investigated polymorphism in the CYP2C19  gene by PCR-RFLP analysis. The CYP2C19*3 AG + AA genotype was significantly  more prevalent in laryngeal carcinoma patients (6.67 vs 2.67%; P =  0.02). Multiple logistic regression analysis showed smoking (odds ratio (OR) =  6.353, 95% confidence interval (CI) = 4.413-9.144; P < 0.001) and alcohol  consumption (OR = 2.607, 95%CI = 1.130-6.016; P = 0.025) as independent risk  factors for laryngeal carcinoma; there was a significant interaction between  CYP2C19*3 and smoking (OR = 17.842, 95%CI = 13.32-31.102; P = 0.009). We  conclude that CYP2C19*3 polymorphism is significantly associated with laryngeal  carcinoma in the Chinese Han population.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, PR China.
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Y-S
authors.initials: YS
authors.lastname: Zhao
authors.forename: S-Q
authors.initials: SQ
authors.lastname: Tang
authors.forename: H-B
authors.initials: HB
authors.lastname: Yang
authors.forename: S-X
authors.initials: SX
authors.lastname: Liu
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D065731:Cytochrome P-450 CYP2C19; D004843:Epistasis, Genetic; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000235:genetics*
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19