title: Factor v Leiden mutation in severe infection and sepsis.
abstract: In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
authors.affiliation: Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
authors.forename: Marcel
authors.initials: M
authors.lastname: Levi
authors.forename: Marcel
authors.initials: M
authors.lastname: Schouten
authors.forename: Cees
authors.initials: C
authors.lastname: van't Veer
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D005165:Factor V / Q000235:genetics*; D006801:Humans; D007239:Infections / Q000097:blood / Q000235:genetics*; D051379:Mice; D009154:Mutation; D018805:Sepsis / Q000097:blood / Q000235:genetics*; D019851:Thrombophilia / Q000097:blood / Q000235:genetics / Q000382:microbiology
chemical_list: D005165:Factor V