title: Recent advances in developing small molecules targeting RNA.
abstract: RNAs are underexploited targets for small molecule drugs or chemical probes of function. This may be due, in part, to a fundamental lack of understanding of the types of small molecules that bind RNA specifically and the types of RNA motifs that specifically bind small molecules. In this review, we describe recent advances in the development and design of small molecules that bind to RNA and modulate function that aim to fill this void.
authors.affiliation: Department of Chemistry, The Kellogg School of Science and Technology, The Scripps Research Institute, Scripps Florida, Jupiter, 33458, United States.
authors.forename: Lirui
authors.initials: L
authors.lastname: Guan
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Disney
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D055029:Inverted Repeat Sequences; D008969:Molecular Sequence Data; D059372:Nucleotide Motifs / Q000235:genetics; D014176:Protein Biosynthesis / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects* / Q000254:growth & development; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors*; D012336:RNA, Ribosomal, 16S / Q000037:antagonists & inhibitors; D012367:RNA, Viral / Q000037:antagonists & inhibitors*; D054657:Ribosome Subunits / Q000187:drug effects; D058928:Riboswitch / Q000187:drug effects; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D012367:RNA, Viral; D058928:Riboswitch; D054852:Small Molecule Libraries