title: Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP.
abstract: jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP.
authors.affiliation: Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. sandy@genetics.utah.edu
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Hasstedt
authors.forename: Alun
authors.initials: A
authors.lastname: Thomas
mesh_terms: D000704:Analysis of Variance; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D058685:Genetic Pleiotropy; D006801:Humans; D020407:Internet; D008957:Models, Genetic; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D012984:Software