title: [Serum levels of interferon-γ, interleukin-6 and tumor necrosis factor-α in patients with cerebral arterial stenosis].
abstract: OBJECTIVE
  To investigate the relationship between interferon-γ(IFN-γ), interleukin-6(IL-6), tumor  necrosis factor-α(TNF-α) and cerebral arterial stenosis and to compare serum levels of these inflammatory  cytokines in different cerebral arteries stenosis groups.
  
  
  METHODS
  According to the stenotic site, patients with  cerebral arteries stenosis were divided into intracranial stenosis group (n=26), extracranial stenosis group  (n=30), intracranial and extracranial stenosis group (n=27), and group of stenosis in middle cerebral artery  (n=25). And there were 33 samples in the control group. Blood serum IFN-γ, IL-6 and TNF-α levels were  analyzed using enzyme linked immunosorbent assays (ELISA).
  
  
  RESULTS
  Serum IFN-γ and IL-6 levels were  significantly increased in all the stenosis groups (P=0.000) as compared with the control group. But serum IFN-γ level had no significant difference between the two optional stenosis groups. And IL-6 level in intracranial  stenosis group was lower than those in the other stenosis groups (P<0.05). In addition, we found that TNF-α of  intracranial stenosis group (P=0.001) and MCA stenosis group (P=0.015) significantly increased as compared with  the control group and the other two stenosis groups.
  
  
  CONCLUSIONS
  The results suggest that IFN-γ, IL-6 and TNF-α are possible to participate in the formation of certain cerebral arterial stenosis.
authors.affiliation: Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Jian-tao
authors.initials: JT
authors.lastname: Liang
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D016893:Carotid Stenosis / Q000097:blood*; D002539:Cerebral Arterial Diseases / Q000097:blood; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D002537:Intracranial Arteriosclerosis / Q000097:blood*; D020768:Middle Cerebral Artery; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma