title: Comparative study of cisplatin-iodized oil suspension and emulsion for transcatheter arterial chemoembolization of rabbit VX2 liver tumors.
abstract: OBJECTIVE
  To evaluate the antitumor effects and hepatotoxicity of transcatheter arterial chemoembolization (TACE) with cisplatin-iodized oil suspension and emulsion in a rabbit tumor model.
  
  
  METHODS
  Transcatheter arterial chemoembolization was performed on 12 rabbits with hepatic VX2 tumors using a cisplatin suspension (1 mg/kg cisplatin and 0.1 mL/kg iodized oil, n = 6) or emulsion (1 mg/kg cisplatin, 0.1 mL/kg of iodized oil, and 0.1 mL/kg saline solution, n = 6). Time series changes in plasma platinum concentration were compared over 24 h. All rabbits were killed at 7 days after TACE, and the growth ratio and residual viable proportion of tumors were calculated on the basis of ultrasonographic and histopathological findings. Hepatotoxicity was also evaluated. Differences between the two groups were statistically assessed with the Mann-Whitney U-test. The animal care committee of our institute approved this study.
  
  
  RESULTS
  Plasma platinum concentrations were significantly higher in the suspension group than in the emulsion group at 0.5-24 h after TACE (P < 0.05). Growth ratios (-24.6 ± 9.98% vs. 21.4 ± 8.87%, respectively; P = 0.004) and residual viable proportions of tumors (25.8 ± 5.02% vs. 51.1 ± 11.4%, respectively; P = 0.009) were significantly lower in the suspension group than in the emulsion group. Hepatotoxicity was transient in all rabbits.
  
  
  CONCLUSIONS
  Cisplatin-iodized oil suspensions facilitated the slow release of cisplatin at the tumor border. A suspension is preferable to an emulsion for drug delivery and the antitumor effect during the treatment of VX2 liver tumors with TACE.
authors.affiliation: Departments of Radiology             Integrative Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Mine
authors.forename: Satoru
authors.initials: S
authors.lastname: Murata
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ueda
authors.forename: Shiro
authors.initials: S
authors.lastname: Onozawa
authors.forename: Munehiko
authors.initials: M
authors.lastname: Onda
authors.forename: Zenya
authors.initials: Z
authors.lastname: Naito
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita