title: Effect of magnesium sulfate therapy on patients with aneurysmal subarachnoid hemorrhage using serum S100B protein as a prognostic marker.
abstract: Magnesium, one of the essential trace elements, plays important roles in maintaining both normal cellular and body functions. S100 calcium-binding protein B (S100B) has been used as a marker of glial damage in several neurological disorders. Thirty patients with ruptured intracranial aneurysms treated by clipping are included. The patients were randomized within 4 days after the attack of hemorrhage. The patients were divided into two groups with 15 patients in each group. Group I received magnesium infusion within 4 days. Group II is the control group. World Federation of Neurological Surgeons, Fisher, and Glasgow outcome scores are evaluated at an intensive care unit in addition to 3 months clinical follow-up evaluation. Samplings of serum S100B were performed on admission and on postoperative days 1, 3, and 7. There is a statistically significant difference between both groups as regards the second reading of the S100B (day 1 postoperative; P < 0.05). There is no statistically significant difference between both groups as regards outcome at 3 months using clinical status and S100B values. There is a tendency in the magnesium group to have better outcomes. Further studies with more number of patients with subarachnoid hemorrhage are needed to determinate the accuracy of S100B protein as a prognostic marker and of magnesium sulfate as a neuroprotector.
authors.affiliation: Department of Neurosurgery, Alexandria University School of Medicine, Elazarita, Shambeleon Street, Alexandria, Egypt. Neurocatheter@yahoo.com
authors.forename: Tamer
authors.initials: T
authors.lastname: Hassan
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Nassar
authors.forename: Sherif Mohammed
authors.initials: SM
authors.lastname: Elhadi
authors.forename: Wafa Kamel
authors.initials: WK
authors.lastname: Radi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000188:drug therapy
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D008278:Magnesium Sulfate