title: Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients.
abstract: Several studies report autoantibody signatures in cancer. The majority of these studies analyzed adult tumors and compared the seroreactivity pattern of tumor patients with the pattern in healthy controls. Here, we compared the autoimmune response in patients with neuroblastoma and patients with Wilms tumor representing two different childhood tumors. We were able to differentiate untreated neuroblastoma patients from untreated Wilms tumor patients with an accuracy of 86.8%, a sensitivity of 87.0% and a specificity of 86.7%. The separation of treated neuroblastoma patients from treated Wilms tumor patients' yielded comparable results with an accuracy of 83.8%. We furthermore identified the antigens that contribute most to the differentiation between both tumor types. The analysis of these antigens revealed that neuroblastoma was considerably more immunogenic than Wilms tumor. The reported antigens have not been found to be relevant for comparative analyses between other tumors and controls. In summary, neuroblastoma appears as a highly immunogenic tumor as demonstrated by the extended number of antigens that separate this tumor from Wilms tumor.
authors.affiliation: Department of Human Genetics, Medical School, Saarland University, Homburg, Germany. jana.schmitt@uniklinikum-saarland.de
authors.forename: Jana
authors.initials: J
authors.lastname: Schmitt
authors.forename: Andreas
authors.initials: A
authors.lastname: Keller
authors.forename: Nasenien
authors.initials: N
authors.lastname: Nourkami-Tutdibi
authors.forename: Sabrina
authors.initials: S
authors.lastname: Heisel
authors.forename: Nunja
authors.initials: N
authors.lastname: Habel
authors.forename: Petra
authors.initials: P
authors.lastname: Leidinger
authors.forename: Nicole
authors.initials: N
authors.lastname: Ludwig
authors.forename: Manfred
authors.initials: M
authors.lastname: Gessler
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
authors.forename: Frank
authors.initials: F
authors.lastname: Berthold
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Lenhof
authors.forename: Eckart
authors.initials: E
authors.lastname: Meese
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology; D019540:Area Under Curve; D001323:Autoantibodies / Q000276:immunology*; D002675:Child, Preschool; D002999:Clone Cells; D003937:Diagnosis, Differential; D006801:Humans; D009447:Neuroblastoma / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D009396:Wilms Tumor / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm; D001323:Autoantibodies