title: Influence of stochastic domain growth on pattern nucleation for diffusive systems with internal noise.
abstract: Numerous mathematical models exploring the emergence of complexity within developmental biology incorporate diffusion as the dominant mechanism of transport. However, self-organizing paradigms can exhibit the biologically undesirable property of extensive sensitivity, as illustrated by the behavior of the French-flag model in response to intrinsic noise and Turing's model when subjected to fluctuations in initial conditions. Domain growth is known to be a stabilizing factor for the latter, though the interaction of intrinsic noise and domain growth is underexplored, even in the simplest of biophysical settings. Previously, we developed analytical Fourier methods and a description of domain growth that allowed us to characterize the effects of deterministic domain growth on stochastically diffusing systems. In this paper we extend our analysis to encompass stochastically growing domains. This form of growth can be used only to link the meso- and macroscopic domains as the "box-splitting" form of growth on the microscopic scale has an ill-defined thermodynamic limit. The extension is achieved by allowing the simulated particles to undergo random walks on a discretized domain, while stochastically controlling the length of each discretized compartment. Due to the dependence of diffusion on the domain discretization, we find that the description of diffusion cannot be uniquely derived. We apply these analytical methods to two justified descriptions, where it is shown that, under certain conditions, diffusion is able to support a consistent inhomogeneous state that is far removed from the deterministic equilibrium, without additional kinetics. Finally, a logistically growing domain is considered. Not only does this show that we can deal with nonmonotonic descriptions of stochastic growth, but it is also seen that diffusion on a stationary domain produces different effects to diffusion on a domain that is stationary "on average."
authors.affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, United Kingdom. woolley@maths.ox.ac.uk
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Woolley
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Baker
authors.forename: Eamonn A
authors.initials: EA
authors.lastname: Gaffney
authors.forename: Philip K
authors.initials: PK
authors.lastname: Maini
mesh_terms: D004058:Diffusion; D006128:Growth / Q000502:physiology*; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes