title: Pharmacological basis and clinical evidence of dabigatran therapy.
abstract: Dabigatran is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. It has been approved in the European Union and the United States of America for the prevention of thrombosis after major orthopedic surgery. It has also been approved by the American Food and Drug Administration and the European Medicines Agency for the prevention of stroke in chronic atrial fibrillation. Dabigatran provides a stable anticoagulation effect without any need to perform periodical laboratory controls. Of note, there is a growing amount of clinical evidence which shows its safety and efficacy. For these reasons, dabigatran may suppose a revolution in oral anticoagulation. However, two important limitations remain. First, it is contraindicated in patients with end-stage renal disease. Second, there is no evidence of the prevention of thrombosis in mechanical heart valves.
authors.affiliation: Service of Hematology, Hospital Nuestra Señora de Sonsoles, Ávila, Spain. santiredondo@hotmail.com
authors.forename: Santiago
authors.initials: S
authors.lastname: Redondo
authors.forename: Maria-Paz
authors.initials: MP
authors.lastname: Martínez
authors.forename: Marta
authors.initials: M
authors.lastname: Ramajo
authors.forename: Jorge
authors.initials: J
authors.lastname: Navarro-Dorado
authors.forename: Abelardo
authors.initials: A
authors.lastname: Barez
authors.forename: Teresa
authors.initials: T
authors.lastname: Tejerina
mesh_terms: D000925:Anticoagulants / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D000069604:Dabigatran; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D013927:Thrombosis / Q000188:drug therapy; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran