title: Intralesional curettage, with phenol and cement as adjuvants, for low-grade intramedullary chondrosarcoma of the long bones.
abstract: The authors conducted a retrospective study on 23 patients (12 females and 11 males) with low-grade intramedullary chondrosarcoma of a long bone, treated with intralesional curettage, phenolization and cementation. The use of phenol was supported by an in vitro study, the use of bone cement by clinical studies. A consensus has been growing that this type of tumours should be treated less aggressively. The average age of the patients was 445 years (range: 29 to 71). The mean follow-up period was 6.2 years (range: 2.5 to 11 years). After 6 months the average Musculoskeletal Tumor Society (MSTS) score was 76.8% of 30, the best possible score (range: 61% to 87%). After 12 months this score increased to 89.8% (range: 63% to 100%). Complications were: one recurrence (43%), treated with a tumour prosthesis, and 3 fractures (13%). The authors strongly support this new technique, all the more as it still allows for a more radical approach, if necessary. They stress the importance of a strict follow-up by a multidisciplinary team, in order to treat local recurrences and (rarely) metastases.
authors.affiliation: Department of Orthopaedic Surgery, Policlinico Umberto I, University La Sapienza, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Giorgio
authors.forename: Georgios
authors.initials: G
authors.lastname: Touloupakis
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vitullo
authors.forename: Luca
authors.initials: L
authors.lastname: Sodano
authors.forename: Marco
authors.initials: M
authors.lastname: Mastantuono
authors.forename: Ciro
authors.initials: C
authors.lastname: Villani
mesh_terms: D000328:Adult; D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery*; D002813:Chondrosarcoma / Q000601:surgery*; D003475:Curettage; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019800:Phenol / Q000008:administration & dosage* / Q000627:therapeutic use*; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*
chemical_list: D001843:Bone Cements; D019800:Phenol; D019904:Polymethyl Methacrylate