title: Synchronous double tumor of breast cancer and gastrointestinal stromal tumor in a patient with neurofibromatosis type 1: report of a case.
abstract: We report a rare case of synchronous double tumor formation of breast cancer and gastrointestinal stromal tumor (GIST) in a patient with neurofibromatosis type 1(NF-1). A 76-year-old woman with a history of NF-1 who had undergone left modified mastectomy for breast cancer seven years previously was admitted to our hospital because of a right breast tumor and abdominal discomfort. Computed tomography revealed an enhanced irregular tumor in the right breast and peripheral enhanced tumors in the abdomen. The patient underwent right modified mastectomy and laparoscopic tumor resection combined with small intestine surgery. Histopathological examination revealed the presence of invasive lobular carcinoma in the right breast and GIST in the abdomen. The synchronous development of breast cancer and GIST in a patient with NF-1 is extremely rare, with this being the second case ever reported.
authors.affiliation: Department of Surgery, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu 874-0011, Japan. t3996@beppu.hosp.go.jp
authors.forename: Hideya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Shozi
authors.initials: S
authors.lastname: Hiroshige
authors.forename: Kenkichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kusumoto
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Muto
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis; D015411:Mastectomy, Modified Radical / Q000379:methods; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000188:drug therapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000970:Antineoplastic Agents