title: [A case of malignant peritoneal mesothelioma successfully treated with concurrent chemoradiotherapy].
abstract: Malignant peritoneal mesothelioma is extremely rare, and its prognosis is poor. The median survival period is said to be approximately one year after diagnosis. We report a case of recurrent malignant peritoneal mesothelioma treated with concurrent chemoradiotherapy (CCRT). The patient has been alive for six years without recurrence. This report seems to be the first that indicates CCRT to be useful for peritoneal mesothelioma. The patient was a 21-year-old woman who underwent emergency surgery of the in acute abdomen at another hospital. The resected tumor was 18 cm in size and pathological examination revealed that it was a malignant mesothelioma of the epithelioid type. CAP therapy (cyclophosphamide+adriamycine+cisplatin)+CPT-11 administration was given only one course, and the patient was then transferred to our hospital. She underwent resection of the residual disease and six courses of TC therapy (paclitaxel+carboplatin) as adjuvant chemotherapy. Twelve months after chemotherapy, pelvic recurrence occurred. We attempted surgery but only biopsy could be performed because of a pelvic wall invasion. The patient underwent CCRT with weekly cisplatin. The tumor was reduced by irradiation of 50. 4 Gy and disappeared after 6 months. No recurrence has been found six years since the last treatment. CCRT might be effective against malignant peritoneal mesothelioma of the epithelioid type.
authors.affiliation: Dept. of Obstetrics and Gynecology, Tokyo Women's University.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Hida
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Ken
authors.initials: K
authors.lastname: Ishitani
authors.forename: Katsuya
authors.initials: K
authors.lastname: Maebayashi
authors.forename: Norio
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsui
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000628:therapy*; D012074:Remission Induction; D055815:Young Adult