title: Thinning of the arterial media layer as a possible preclinical stage in HIV vasculopathy: a pilot study.
abstract: OBJECTIVE
  The purpose of this study was to determine if postmortem intracranial arteries from donors with HIV without stroke have thinner media layers compared with patients without HIV and without stroke.
  
  
  METHODS
  Cross-sectional cuts from intracranial arteries were stained with van Gieson and hematoxylin and eosin. Arteries were examined for thickness of each arterial layer. Univariable and multivariable models were used for statistical analyses with probability values <0.05 considered significant.
  
  
  RESULTS
  A total of 18 brains were analyzed, 5 with HIV and 13 without. Fifty-five arteries were collected, 15 from HIV brains and 40 from unaffected controls. In univariable analysis, in arteries from HIV-infected brains, the media to wall thickness ratio was smaller than in donors without HIV (0.496 versus 0.563, P=0.017). In multivariable analysis, HIV infection was the only independent predictor of smaller media ratios compared with the same-aged control subjects (P=0.049) but not with aged control subjects (P=0.081).
  
  
  CONCLUSIONS
  In patients with HIV without clinical stroke, the media arterial layer is thinner than in patients without HIV. This suggests that a thinner media layer might be a preclinical stage in the development of HIV-related vasculopathy.
authors.affiliation: MPH, The Neurological Institute of New York, 710 West 168th Street, 6th Floor, New York, NY 10032, USA. jg3233@columbia.edu
authors.forename: Jose
authors.initials: J
authors.lastname: Gutierrez
authors.forename: Melanie
authors.initials: M
authors.lastname: Glenn
authors.forename: Richard S
authors.initials: RS
authors.lastname: Isaacson
authors.forename: Angelica Dawn
authors.initials: AD
authors.lastname: Marr
authors.forename: Deborah
authors.initials: D
authors.lastname: Mash
authors.forename: Carol
authors.initials: C
authors.lastname: Petito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002536:Cerebral Arteries / Q000473:pathology*; D005260:Female; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020521:Stroke / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*