title: Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study.
abstract: OBJECTIVE
  Melanoma-associated antigens-A (MAGE-A) family is a group of well-characterized cancer/testis antigens (CTA), because they are strictly tumor specific and are shared by many kinds of tumors. However, the expression pattern of MAGE-A10 and MAGE-A11 in breast cancer patients is still unclear. The purpose of our study is to investigate the expression pattern and prognostic significance of MAGE-A10 and MAGE-A11 in breast cancer patients.
  
  
  METHODS
  Formalin-fixed and paraffin-embedded tissues and the clinicopathological parameters from 75 primary breast cancer patients were collected. The expressions of MAGE-A10 and MAGE-A11 proteins were immunohistochemically detected, and the association of MAGE-A10 and MAGE-A11 expressions with the clinicopathological parameters and the survival of breast cancer patients were analyzed.
  
  
  RESULTS
  The expression rates of MAGE-A10 and MAGE-A11 in breast cancer specimens were 73.3 and 52.0%, respectively. MAGE-A11 expression was more frequent in estrogen-receptor (ER)-positive breast carcinomas compared with ER-negative breast carcinomas (P = 0.004). MAGE-A11 expression was positively associated with HER-2 expression (P = 0.003). Overall survival of patients with MAGE-A11-negative expression was significantly longer than those patients with positive MAGE-A11 expression (P = 0.030), but no difference of overall survival was found between patients with MAGE-A10-negative and -positive expression (P = 0.881).
  
  
  CONCLUSIONS
  MAGE-A10 and MAGE-A11 are tumor-specific antigens, and MAGE-A11 expression probably is a potential poor prognostic factor for breast cancer patients.
authors.affiliation: Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017 Hebei, People's Republic of China.
authors.forename: Yishui
authors.initials: Y
authors.lastname: Lian
authors.forename: Meixiang
authors.initials: M
authors.lastname: Sang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ding
authors.forename: Xinliang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Fan
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xu
authors.forename: Weihua
authors.initials: W
authors.lastname: Lü
authors.forename: Baoen
authors.initials: B
authors.lastname: Shan
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C121012:MAGEA10 protein, human; C110882:MAGEA11 protein, human; D009363:Neoplasm Proteins