title: Moderators and mediators of remission in family-based treatment and adolescent focused therapy for anorexia nervosa.
abstract: Few of the limited randomized controlled trails (RCTs) for adolescent anorexia nervosa (AN) have explored the effects of moderators and mediators on outcome. This study aimed to identify treatment moderators and mediators of remission at end of treatment (EOT) and 6- and 12-month follow-up (FU) for adolescents with AN (N = 121) who participated in a multi-center RCT of family-based treatment (FBT) and individual adolescent focused therapy (AFT). Mixed effects modeling were utilized and included all available outcome data at all time points. Remission was defined as ≥ 95% IBW plus within 1 SD of the Eating Disorder Examination (EDE) norms. Eating related obsessionality (Yale-Brown-Cornell Eating Disorder Total Scale) and eating disorder specific psychopathology (EDE-Global) emerged as moderators at EOT. Subjects with higher baseline scores on these measures benefited more from FBT than AFT. AN type emerged as a moderator at FU with binge-eating/purging type responding less well than restricting type. No mediators of treatment outcome were identified. Prior hospitalization, older age and duration of illness were identified as non-specific predictors of outcome. Taken together, these results indicate that patients with more severe eating related psychopathology have better outcomes in a behaviorally targeted family treatment (FBT) than an individually focused approach (AFT).
authors.affiliation: The University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave., MC3077, Chicago, IL 60637, USA. legrange@uchicago.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Le Grange
authors.forename: James
authors.initials: J
authors.lastname: Lock
authors.forename: W Stewart
authors.initials: WS
authors.lastname: Agras
authors.forename: Ann
authors.initials: A
authors.lastname: Moye
authors.forename: Susan W
authors.initials: SW
authors.lastname: Bryson
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.forename: Helena C
authors.initials: HC
authors.lastname: Kraemer
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D000856:Anorexia Nervosa / Q000523:psychology* / Q000628:therapy*; D002648:Child; D005196:Family Therapy / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011613:Psychotherapy / Q000379:methods / Q000706:statistics & numerical data*; D012074:Remission Induction / Q000379:methods*; D012307:Risk Factors