title: Smart hybrid materials equipped by nanoreservoirs of therapeutics.
abstract: Nanobiotechnology enables the emergence of entirely new classes of bioactive devices intended for targeted intracellular delivery for more efficacies and less toxicities. Among organic and inorganic approaches currently developed, controlled release from polymer matrices promises utmost clinical impact. Here, a unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine. The cell contact-dependent bioerodable nanoreservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated cell-therapy implants capable of robust and durable regeneration of a broad variety of tissues.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 977, 11 rue Humann, 67085 Strasbourg, France.
authors.forename: Carlos
authors.initials: C
authors.lastname: Mendoza-Palomares
authors.forename: Alice
authors.initials: A
authors.lastname: Ferrand
authors.forename: Sybille
authors.initials: S
authors.lastname: Facca
authors.forename: Florence
authors.initials: F
authors.lastname: Fioretti
authors.forename: Guy
authors.initials: G
authors.lastname: Ladam
authors.forename: Sabine
authors.initials: S
authors.lastname: Kuchler-Bopp
authors.forename: Thomas
authors.initials: T
authors.lastname: Regnier
authors.forename: Didier
authors.initials: D
authors.lastname: Mainard
authors.forename: Nadia
authors.initials: N
authors.lastname: Benkirane-Jessel
mesh_terms: D020341:Absorbable Implants; D003460:Crystallization / Q000379:methods*; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D053769:Nanocapsules; D011108:Polymers