title: Synthesis of a [2.2]paracyclophane based planar chiral palladacycle by a highly selective kinetic resolution/C-H activation reaction.
abstract: Kinetic resolution of racemic 4-N,N-dimethylaminomethyl[2.2]paracyclophane with 50% sodium tetrachloropalladate and (R)-N-acetylphenylalanine under basic conditions resulted in the formation of a (S(p))-planar chiral palladacycle (35%, >99% ee). Similarly use of 100 mol% sodium tetrachloropalladate resulted in higher levels of conversion and recovery of (S(p))-4-N,N-dimethylaminomethyl[2.2]paracyclophane (41%, >97% ee).
authors.affiliation: School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dendele
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bisaro
authors.forename: Annie-Claude
authors.initials: AC
authors.lastname: Gaumont
authors.forename: Stephane
authors.initials: S
authors.lastname: Perrio
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Richards