title: Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates.
abstract: Whole-genome analysis by 62-strain microarray showed variation in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicillin-resistant Staphylococcus aureus (MRSA) strain CC22-SCCmecIV but also showed (i) detection of two previously unrecognized MRSA transmission events and (ii) that 7/8 patients were infected with a variant of their own colonizing isolate.
authors.affiliation: Centre for Infection, Division of Clinical Sciences, St George’s University of London, London, United Kingdom. jlindsay@sgul.ac.uk
authors.forename: Alex J
authors.initials: AJ
authors.lastname: McCarthy
authors.forename: Aodhan S
authors.initials: AS
authors.lastname: Breathnach
authors.forename: Jodi A
authors.initials: JA
authors.lastname: Lindsay
mesh_terms: D002353:Carrier State / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D014644:Genetic Variation; D016680:Genome, Bacterial; D005838:Genotype; D006761:Hospitals; D006801:Humans; D020071:Interspersed Repetitive Sequences; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D046228:Microarray Analysis; D017720:Molecular Epidemiology; D058889:Molecular Typing; D013203:Staphylococcal Infections / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors