title: Inherited epidermolysis bullosa - the spectrum of complications.
abstract: Epidermolysis bullosa is a group of inherited diseases that are characterized by skin and mucosal fragility and blister formation. A wide variety of extracutaneous manifestations can develop as well as various complications of the disease such as severe anemia, growth retardation, esophageal stenosis, mutilating deformities of hands and feet, glomerulonephritis leading to chronic renal failure, and many others. One of the most important and often occurring complications is the development of cutaneous squamous cell carcinomas that grow and metastasize quickly. The objective of this paper is to give dermatologists a review of major complications encountered in patients with epidermolysis bullosa. Since these complications occur so often and can be considered to be part of the clinical picture, it is mandatory to develop a multidisciplinary well-educated team involved in follow-up and treatment of these patients.
authors.affiliation: University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine University of Zagreb, Croatia. slosusic@vef.hr
authors.forename: Slobodna
authors.initials: S
authors.lastname: Murat-Sušić
authors.forename: Karmela
authors.initials: K
authors.lastname: Husar
authors.forename: Mihael
authors.initials: M
authors.lastname: Skerlev
authors.forename: Branka
authors.initials: B
authors.lastname: Marinović
authors.forename: Irena
authors.initials: I
authors.lastname: Babić
mesh_terms: D000740:Anemia / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D002648:Child; D002908:Chronic Disease; D004820:Epidermolysis Bullosa / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000209:etiology; D006226:Hand Deformities / Q000209:etiology; D006801:Humans; D009369:Neoplasms / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology