title: Copper(II)-catalyzed synthesis of benzo[f]pyrido[1,2-a]indole-6,11-dione derivatives via naphthoquinone difunctionalization reaction.
abstract: Benzo[f]pyrido[1,2-a]indole-6,11-diones have been synthesized in high yields by copper(II)-catalyzed three-component reactions of acyl bromide, 1,4-naphthoquinone, and pyridine (or isoquinoline) via sp(2)-C-H difunctionalization of naphthoquinone followed by intramolecular cyclization and oxidative aromatization. In an attempt to expand the reaction scope and to help clarify the reaction mechanism, 1,3-dicarbonyl compounds are used in place of acyl bromides to take part in this reaction, and the benzo[f]pyrido[1,2-a]indole-6,11-diones derivatives are also obtained in excellent yields.
authors.affiliation: Institute of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China. liu__yun3@sina.com.cn
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Sun