title: An efficient method for the preparation of tertiary esters by palladium-catalyzed alkoxycarbonylation of aryl bromides.
abstract: The palladium-catalyzed alkoxycarbonylation of aryl bromides is described for the efficient preparation of tertiary esters. The protocol proved compatible with a wide variety of functionalized (hetero)aromatic bromides, as well as several different sterically hindered tertiary alcohols, affording the alkoxycarbonylated products in high yields. Finally, the formation of aromatic trityl esters is discussed.
authors.affiliation: Department of Chemistry, Center for Insoluble Protein Structures (InSpin), and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Xin
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gøgsig
authors.forename: Anders T
authors.initials: AT
authors.lastname: Lindhardt
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D004952:Esters; D010165:Palladium