title: Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D.
abstract: Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to-mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.
authors.affiliation: Viral Oncology Program, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. emesri@med.miami.edu
authors.forename: Enrique A
authors.initials: EA
authors.lastname: Mesri
authors.forename: Ethel
authors.initials: E
authors.lastname: Cesarman