title: Calculating critical relative humidity from solubility according to nonelectrolyte Wilson nonrandom factor model.
abstract: The critical relative humidity (H(cr)) of 25 drugs and chemicals was determined by the air humidity in equilibrium (AHE) method. The relationship between the H(cr) and the solubility was explored theoretically, and the H(cr) was calculated according to the nonelectrolyte Wilson nonrandom factor (N-Wilson-NRF) model or Raoult's law from their solubility. The results indicate that the calculated H(cr) is comparable to the measured one.
authors.affiliation: Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University , Chengdu, Sichuan, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Luo
authors.forename: Yingli
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiancheng
authors.initials: X
authors.lastname: Zhan
authors.forename: Linli
authors.initials: L
authors.lastname: Li
authors.forename: Chengrong
authors.initials: C
authors.lastname: Li
mesh_terms: D006813:Humidity; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D014867:Water