title: Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1.
abstract: Aciclovir (ACV)-resistant Herpes simplex virus type-2 (HSV-2) infections are observed commonly in patients also infected with HIV-1. The use of foscarnet (FOS) in these patients may also lead to resistance. This situation can become a difficult therapeutic challenge. Four cases of patients infected with HIV and with mucocutaneous HSV-2 resistant to ACV and FOS are reported. These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions.
authors.affiliation: Department of Clinical Immunology, Hôpital Henri Mondor, Créteil, France. anne-sophie.lascaux@hmn.aphp.fr
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Lascaux
authors.forename: Eric
authors.initials: E
authors.lastname: Caumes
authors.forename: Claire
authors.initials: C
authors.lastname: Deback
authors.forename: Giovanna
authors.initials: G
authors.lastname: Melica
authors.forename: Dominique
authors.initials: D
authors.lastname: Challine
authors.forename: Henri
authors.initials: H
authors.lastname: Agut
authors.forename: Yves
authors.initials: Y
authors.lastname: Lévy
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000287:Administration, Topical; D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D017245:Foscarnet / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019888:Nelfinavir / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects*; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D000634:Aminoquinolines; D000998:Antiviral Agents; D019259:Lamivudine; D017245:Foscarnet; D015215:Zidovudine; D019888:Nelfinavir; D000077271:Imiquimod; D000212:Acyclovir