title: Unstimulated whole saliva parathyroid hormone in postmenopausal women with xerostomia.
abstract: OBJECTIVE
  The aim of this study was to evaluate the correlation of xerostomia severity with unstimulated saliva parathyroid hormone (PTH) and to compare unstimulated whole saliva PTH between postmenopausal women with/without xerostomia.
  
  
  METHODS
  A case-control study was carried out in 60 (30 as case and 30 as control) selected postmenopausal women with/ without xerostomia conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was also used as an index of xerostomia severity. PTH concentration was analyzed by enzyme-linked immunosorbent assay (ELISA). Statistical analysis of Student's t-test and Spearman correlation was used.
  
  
  RESULTS
  The mean unstimulated saliva PTH concentration was significantly higher but flow rate was lower in the case group compared with control. XI score correlated significantly with saliva PTH (r = 0.688, p = 0.001) and flow rate (r = - 0.529, p = 0.001).
  
  
  CONCLUSIONS
  Xerostomia severity correlated positively with unstimulated whole saliva PTH and negatively with saliva flow rate in this group of postmenopausal women. Thus, salivary flow rate and PTH levels appear associated with xerostomia and menopause.
  
  
  CONCLUSIONS
  Salivary PTH level appears to be associated with xerostomia and menopause.
authors.affiliation: Department of Physiology, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Agha-Hosseini
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis / Q000378:metabolism*; D017698:Postmenopause / Q000502:physiology*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism*; D012636:Secretory Rate; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000503:physiopathology*
chemical_list: D010281:Parathyroid Hormone