title: [Complex study of the mutagenic effect of soil pollutions with petrochemical products in the Chechen Republic].
abstract: A study to evaluate congenital morphogenetic variants (CMGVs) and the association of the polymorphism of the xenobiotic detoxification and repair genes with cytogenetic parameters was conducted for the first time in children living in different climatic zones and areas polluted with primary petroleum refining products. Analysis of CMGVs and cytogenetic parameters in children points to the total genotoxic impact of oil pollutions. The children's higher sensitivity to environmental pollution is associated with the polymorphism of the detoxification gene, with the base excision repair gene XRCC1 in particular.
authors.forename: A M-Kh
authors.initials: AM
authors.lastname: Soltaeva
authors.forename: P M
authors.initials: PM
authors.lastname: Dzhambetova
authors.forename: S K
authors.initials: SK
authors.lastname: Abilev
authors.forename: L P
authors.initials: LP
authors.lastname: Sycheva
authors.forename: L E
authors.initials: LE
authors.lastname: Sal'nikova
authors.forename: A V
authors.initials: AV
authors.lastname: Rubanovich
mesh_terms: D002648:Child; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000706:statistics & numerical data; D020732:Cytogenetic Analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D059392:Petroleum Pollution / Q000009:adverse effects* / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000633:toxicity*; D012426:Russia; D012987:Soil / Q000032:analysis*; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity*; D000076105:X-ray Repair Cross Complementing Protein 1; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D004268:DNA-Binding Proteins; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; D012987:Soil; D012989:Soil Pollutants; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D015262:Xenobiotics