title: Axonal fiber terminations concentrate on gyri.
abstract: Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.
authors.affiliation: Department of Automatic Control, School of Automation, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Nie
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Kaiming
authors.initials: K
authors.lastname: Li
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Wang
authors.forename: Guojun
authors.initials: G
authors.lastname: Chen
authors.forename: Longchuan
authors.initials: L
authors.lastname: Li
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.forename: Fan
authors.initials: F
authors.lastname: Deng
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.forename: Carlos
authors.initials: C
authors.lastname: Faraco
authors.forename: Degang
authors.initials: D
authors.lastname: Zhang
authors.forename: Cong
authors.initials: C
authors.lastname: Guo
authors.forename: Pew-Thian
authors.initials: PT
authors.lastname: Yap
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Jinglei
authors.initials: J
authors.lastname: Lv
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Junwei
authors.initials: J
authors.lastname: Han
authors.forename: Dean
authors.initials: D
authors.lastname: Sabatinelli
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.forename: L Stephen
authors.initials: LS
authors.lastname: Miller
authors.forename: Bingqian
authors.initials: B
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Shen
authors.forename: Simon
authors.initials: S
authors.lastname: Platt
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D002540:Cerebral Cortex / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008251:Macaca / Q000033:anatomy & histology*; D008297:Male; D009434:Neural Pathways / Q000648:ultrastructure*; D002679:Pan troglodytes / Q000033:anatomy & histology*; D013045:Species Specificity; D055815:Young Adult