title: The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies.
abstract: BACKGROUND
  APE1 (apurinic/apyrimidinic endonuclease 1) is an important DNA repair protein in the base excision repair pathway. Polymorphisms in APE1 have been implicated in susceptibility to cancer; however, results from the published studies remained inconclusive. The objective of this study was to conduct a meta-analysis investigating the association between polymorphisms in APE1 and the risk for cancer.
  
  
  METHODS
  The PubMed and Embase databases were searched for case-control studies published up to June, 2011 that investigated APE1 polymorphisms and cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations.
  
  
  RESULTS
  Two polymorphisms (-656 T > G, rs1760944 and 1349 T > G, rs1130409) in 37 case-control studies including 15, 544 cancer cases and 21, 109 controls were analyzed. Overall, variant genotypes (GG and TG/GG) of -656 T > G polymorphism were associated with significantly decreased cancer risk in homozygote comparison (OR = 0.81, 95%CI: 0.67-0.97), dominant model comparison (OR = 0.89, 95%CI: 0.81-0.97) and recessive model comparison (OR = 0.90, 95%CI: 0.82-0.98), whereas the 1349 T > G polymorphism had no effects on overall cancer risk. In the stratified analyses for -656 T > G polymorphism, there was a significantly decreased risk of lung cancer and among Asian populations.
  
  
  CONCLUSIONS
  Although some modest bias could not be eliminated, the meta-analysis suggests that APE1 -656 T > G polymorphism has a possible protective effect on cancer risk particularly among Asian populations whereas 1349 T > G polymorphism does not contribute to the development of cancer.
authors.affiliation: Department of General Surgery, Jiangyin People's Hospital, South-East University, Jiangyin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Hailin
authors.initials: H
authors.lastname: Shan
authors.forename: Ying
authors.initials: Y
authors.lastname: Su
authors.forename: Kai
authors.initials: K
authors.lastname: Xia
authors.forename: Xiaxia
authors.initials: X
authors.lastname: Shao
authors.forename: Weidong
authors.initials: W
authors.lastname: Mao
authors.forename: Qing
authors.initials: Q
authors.lastname: Shao
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase