title: Formulation and in vitro evaluation of self-emulsifying formulations of Cinnarizine.
abstract: The main objectives of this study were to improve the aqueous solubility and to modify in vitro dissolution profile of hydrophobic drug using self-emulsifying drug delivery systems (SEDDS). SEDDS were formulated using Capmul PG-12, Cremophor RH 40 and Tween 20 at different weight ratios and incorporated with Cinnarizine. The drug incorporation into pre-concentrate and drug solubility in phosphate buffer (pH 7.2) were investigated. In addition, the mean droplet size and drug release profile of the SEDDS were also determined. The drug incorporation was over 120 mg per 0.5 g pre-concentrate regardless of the composition of the formulations. The solubility of Cinnarizine in phosphate buffer (pH 7.2) was at least 1500 μM in the SEDDS. Formulations with only 10% w/w Capmul PG-12 were less than 20 nm in mean diameter while those produced with at least 20% w/w Capmul PG-12 were more than 100 nm regardless of the ratios of Cremophor RH 40 to Tween 20. SEDDS showed a significant increase of the mean percentage drug release than pure drug (p < 0.0001). In general, the SEDDS with 30% w/w of Capmul PG-12 provided the greatest enhancement in drug solubility in phosphate buffer as well as rapid drug release despite forming larger droplets upon emulsification. The combination of Capmul PG-12, Tween 20 and Cremophor RH 40 can produce SEDDS which can be used as an alternative dosage form for poorly water soluble drug.
authors.affiliation: Department of Pharmacy, Health and Well Being, University of Sunderland, Sunderland, UK.
authors.forename: Shyam
authors.initials: S
authors.lastname: Vithlani
authors.forename: Shruthi
authors.initials: S
authors.lastname: Sarraf
authors.forename: Cheng Shu
authors.initials: CS
authors.lastname: Chaw
mesh_terms: D002021:Buffers; D002210:Caprylates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002936:Cinnarizine / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry; D005989:Glycerides / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D002021:Buffers; D002210:Caprylates; D045703:Emulsifying Agents; D004655:Emulsions; D005989:Glycerides; D010710:Phosphates; D011136:Polysorbates; D013501:Surface-Active Agents; D014867:Water; C022131:cremophor; D002936:Cinnarizine; D011092:Polyethylene Glycols; C025343:monooctanoin