title: One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome.
abstract: OBJECTIVE
  To evaluate the 12-month effect of myo-inositol treatment on some biochemical parameters of women affected by metabolic syndrome.
  
  
  METHODS
  Eighty outpatient postmenopausal women, affected by metabolic syndrome, were enrolled in a 12-month study. All women were treated with a low-energy diet, and then they were randomly assigned to myo-inositol 2 g b.i.d. (n = 40) or placebo (n = 40). All the women were evaluated for serum glucose, insulin, HOMA-IR (Homeostasis Model Assessment-Insulin Resistance), triglycerides, total and high density lipoprotein cholesterol, body mass index (BMI), waist circumference and blood pressure at baseline and after 12 months of treatment.
  
  
  RESULTS
  With the exception of BMI and waist circumference, after 12 months of treatment, all the parameters studied showed a significant improvement in the myo-inositol group compared to the control group. At the end of the study, in the myo-inositol group, the number of women without metabolic syndrome was eight (20%) whereas, in the control group, only one woman no longer had the metabolic syndrome after 12 months of diet.
  
  
  CONCLUSIONS
  Myo-inositol might be considered one of the insulin-sensitizing substances in the treatment of metabolic syndrome.
authors.affiliation: Department of Obstetrics and Gynecological Sciences, University of Messina, Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Santamaria
authors.forename: D
authors.initials: D
authors.lastname: Giordano
authors.forename: F
authors.initials: F
authors.lastname: Corrado
authors.forename: B
authors.initials: B
authors.lastname: Pintaudi
authors.forename: M L
authors.initials: ML
authors.lastname: Interdonato
authors.forename: G Di
authors.initials: GD
authors.lastname: Vieste
authors.forename: A Di
authors.initials: AD
authors.lastname: Benedetto
authors.forename: R
authors.initials: R
authors.lastname: D'Anna
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D031204:Caloric Restriction; D008076:Cholesterol, HDL / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D010919:Placebos; D017698:Postmenopause; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D010919:Placebos; D014280:Triglycerides; D007294:Inositol