title: Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study.
abstract: BACKGROUND
  Main pulmonary artery diameter (mPA) and ratio of mPA to ascending aorta diameter (ratio PA) derived from chest CT are commonly reported in clinical practice. We determined the age- and sex-specific distribution and normal reference values for mPA and ratio PA by CT in an asymptomatic community-based population.
  
  
  RESULTS
  In 3171 men and women (mean age, 51±10 years; 51% men) from the Framingham Heart Study, a noncontrast, ECG-gated, 8-slice cardiac multidetector CT was performed. We measured the mPA and transverse axial diameter of the ascending aorta at the level of the bifurcation of the right pulmonary artery and calculated the ratio PA. We defined the healthy referent cohort (n=706) as those without obesity, hypertension, current and past smokers, chronic obstructive pulmonary disease, history of pulmonary embolism, diabetics, cardiovascular disease, and heart valve surgery. The mean mPA diameter in the overall cohort was 25.1±2.8 mm and mean ratio PA was 0.77±0.09. The sex-specific 90th percentile cutoff value for mPA diameter was 28.9 mm in men and 26.9 mm in women and was associated with increase risk for self-reported dyspnea (adjusted odds ratio, 1.31; P=0.02). The 90th percentile cutoff value for ratio PA of the healthy referent group was 0.91, similar between sexes but decreased with increasing age (range, 0.82-0.94), though not associated with dyspnea.
  
  
  CONCLUSIONS
  For simplicity, we established 29 mm in men and 27 mm in women as sex-specific normative reference values for mPA and 0.9 for ratio PA.
authors.affiliation: Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. qtruong@partners.org
authors.forename: Quynh A
authors.initials: QA
authors.lastname: Truong
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Massaro
authors.forename: Ian S
authors.initials: IS
authors.lastname: Rogers
authors.forename: Amir A
authors.initials: AA
authors.lastname: Mahabadi
authors.forename: Matthias F
authors.initials: MF
authors.lastname: Kriegel
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
mesh_terms: D017677:Age Distribution; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011651:Pulmonary Artery / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D012016:Reference Values; D017678:Sex Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*