Implications of RNA helicases in HIV-1 replication: possible roles in latency.
HAART treatment has greatly improved life expectancy of HIV-1-infected individuals. Unfortunately, latency still remains the major barrier towards HIV-1 eradication. Efforts to identify viral and host cell proteins involved in latency remain important research areas to win this war against HIV-1. Here, we review the contributions of several factors in the establishment of latently infected cells. In addition, we also raise the possibility that RNA helicases, while playing important roles at almost every step of the HIV-1 replication cycle, could be implicated in the processes governing the establishment of these latent reservoirs.
Lady Davis Institute for Medical Research-Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada.
Lara
L
Ajamian
Andrew J
AJ
Mouland
D019380:Anti-HIV Agents / Q000627:therapeutic use; D004197:Disease Reservoirs / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000201:enzymology* / Q000502:physiology; D006801:Humans; D020365:RNA Helicases / Q000502:physiology*; D017735:Virus Latency / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology*
D019380:Anti-HIV Agents; D020365:RNA Helicases