Antifungal activity of plumericin and isoplumericin.
This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India.
Dharmendra
D
Singh
Umakant
U
Sharma
Parveen
P
Kumar
Yogesh K
YK
Gupta
M P
MP
Dobhal
Sarman
S
Singh
D000935:Antifungal Agents / Q000302:isolation & purification*; D029062:Apocynaceae / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D007192:Indenes / Q000302:isolation & purification*; D039823:Iridoids / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry
D000935:Antifungal Agents; D007192:Indenes; D039823:Iridoids; D010936:Plant Extracts; C516952:isoplumericin; C068511:plumericin