[Odontoclasts and calcitonin].
Although it is believed that odontoclasts, which mediated root resorption of deciduous teeth, possess common properties to osteoclasts, these regulatory mechanisms differ from osteoclastic bone resorption. It is well established that calcitonin receptor is an important osteoclast marker and that calcitonin is a potent inhibitory hormone of osteoclastic bone resorption. However, the presence and function of calcitonin receptors in human odontoclasts are still controversial. We summarize the physiological properties and differentiation mechanisms of odontoclasts, and the effects of calcitonin on root resorption, including our recent results using human odontoclasts and periodontal ligament cells freshly isolated from deciduous tooth roots.
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Japan.
Koji
K
Okabe
Fujio
F
Okamoto
Hiroshi
H
Kajiya
D000818:Animals; D002116:Calcitonin / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans; D010010:Osteoclasts / Q000378:metabolism / Q000502:physiology*; D010513:Periodontal Ligament / Q000166:cytology; D053245:RANK Ligand / Q000502:physiology; D018003:Receptors, Calcitonin / Q000378:metabolism / Q000502:physiology; D012391:Root Resorption; D015398:Signal Transduction / Q000502:physiology; D014094:Tooth, Deciduous / Q000166:cytology*
D053245:RANK Ligand; D018003:Receptors, Calcitonin; D002116:Calcitonin