[Intestinal absorption of enteric coating potassium sodium dehydroandroan drographolide succinate pellets in rat and in vivo pharmacokinetics study].
OBJECTIVE
To develop a method for determination the content of Potassium Sodium Dehydroandroan drographolide Succinate (PSDS) in rat intestinal contents and plasma and investigate the intestinal absorption of PSDS pellets in rat and in vivo pharmacokinetics of PSDS pellets.


METHODS
The content of PSDS in rat intestinal contents and plasma was determined by HPLC. In vivo pharmacokinetic properties and intestinal absorption of PSDS pellets in rat were investigated.


RESULTS
Two hours after administration, pellets were not found in the small intestine and large intestine, four hours after administration, the largest number of pellets were found in the small intestine and the concentration of PSDS was the highest in the intestinal contents (3593.13 microg). The characteristics of plasma concentration-time curve was consistent with a single compartment model. The main drug pharmacokinetic parameters were calculated. t1/2, T(max), C(max) and AUC were 2.69 h, 5 h, 3.02 microg/mL and 6.42 microg x h/mL, respectively.


CONCLUSIONS
PSDS has a good absorption in the rat small intestine and it is feasible to prepare PSDS enteric-coated pellets for oral administration.
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. ggiyan@sina.com
Yan
Y
Gao
Zhong-Lan
ZL
Wang
Gui-Hua
GH
Huang
D000284:Administration, Oral; D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D007408:Intestinal Absorption; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D013608:Tablets, Enteric-Coated; C030419:andrographolide; D019802:Succinic Acid