In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis.
BACKGROUND
Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties.


METHODS
Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest.


RESULTS
In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum.


CONCLUSIONS
FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.
Universidade Federal de São João Del-Rei, Divinópolis, MG, Brasil. luarsantos@ufsj.edu.br
Luciana Alves Rodrigues dos Santos
LA
Lima
Susana
S
Johann
Patrícia Silva
PS
Cisalpino
Lúcia Pinheiro Santos
LP
Pimenta
Maria Amélia Diamantino
MA
Boaventura
D031041:Annona / Q000737:chemistry*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects; D056285:Cryptococcus gattii / Q000187:drug effects; D005227:Fatty Acids / Q000302:isolation & purification / Q000494:pharmacology*; D008738:Methyl Ethers / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010228:Paracoccidioides / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
D000935:Antifungal Agents; D005227:Fatty Acids; D008738:Methyl Ethers; D010936:Plant Extracts