Is it time for in silico simulation of drug cardiac side effects?
Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models?
Department of Computer Science, University of Oxford, Oxford, United Kingdom. gary.mirams@cs.ox.ac.uk
Gary R
GR
Mirams
Denis
D
Noble
D000818:Animals; D004353:Drug Evaluation, Preclinical; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors; D008955:Models, Cardiovascular; D016171:Torsades de Pointes / Q000139:chemically induced
D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; D007473:Ion Channels