Nonlipidized juvenile xanthogranuloma: an unusual variant with a potential diagnostic pitfall.
Juvenile xanthogranuloma (JXG) is a histiocytic inflammatory disorder that can present different histologic patterns. Classic JXG consists of sheets of foamy histiocytes and numerous multinucleated Touton giant cells. Nonlipidized JXG (NJXG) is one of the unusual variants of JXG, consisting of a diffuse monomorphic infiltrate of mononuclear histiocytes, suggesting an aggressive or malignant tumor due the high mitotic index. However, NJXG behaves clinically as classic JXG. We present an unusual case of a 6-year-old boy who presented an exophytic ulcerated nodule on the lower lip diagnosed as NJXG. The boy is currently well without recurrence three years after surgical excision.
Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
Aline Carvalho
AC
Batista
Elismauro Francisco
EF
Mendonça
Larissa Santana
LS
Arantes Elias
Bruno Augusto Benevenuto
BA
Andrade
Oslei Paes
OP
Almeida
Jorge Esquiche
JE
León
D001707:Biopsy, Needle; D002648:Child; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008046:Lip / Q000473:pathology* / Q000601:surgery; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery; D012883:Skin Ulcer / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis / Q000473:pathology*