Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria.
The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids, alcohols, and amines to enable profiling the susceptibilities of the different mycobacterial species to the physicochemical properties of these amphiphiles. Several dendritic amphiphiles showed strong anti-mycobacterial activity with high critical micelle concentrations and low hemolytic activities thereby offering platforms for the development of antibiotics of higher activity against nontuberculous mycobacteria.
Department of Biological Science (0406), Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. jofiii@vt.edu
Joseph O
JO
Falkinham
Richard V
RV
Macri
Bhadreshkumar B
BB
Maisuria
Marcelo L
ML
Actis
Eko W
EW
Sugandhi
André A
AA
Williams
Alyson V
AV
Snyder
Faunice R
FR
Jackson
Michael A
MA
Poppe
Liang
L
Chen
Krithika
K
Ganesh
Richard D
RD
Gandour
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024881:Drug Resistance, Bacterial; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008560:Membrane Fluidity / Q000187:drug effects; D008823:Micelles; D008826:Microbial Sensitivity Tests / Q000379:methods; D009162:Mycobacterium avium / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013696:Temperature
D000900:Anti-Bacterial Agents; D050091:Dendrimers; D008823:Micelles