Nanoscale plasmonic interferometers for multispectral, high-throughput biochemical sensing.
In this work, we report the design, fabrication, and characterization of novel biochemical sensors consisting of nanoscale grooves and slits milled in a metal film to form two-arm, three-beam, planar plasmonic interferometers. By integrating thousands of plasmonic interferometers per square millimeter with a microfluidic system, we demonstrate a sensor able to detect physiological concentrations of glucose in water over a broad wavelength range (400-800 nm). A wavelength sensitivity between 370 and 630 nm/RIU (RIU, refractive index units), a relative intensity change between ~10(3) and 10(6) %/RIU, and a resolution of ~3 × 10(-7) in refractive index change were experimentally measured using typical sensing volumes as low as 20 fL. These results show that multispectral plasmonic interferometry is a promising approach for the development of high-throughput, real-time, and extremely compact biochemical sensors.
School of Engineering, Brown University, Providence, Rhode Island 02912, USA.
Jing
J
Feng
Vince S
VS
Siu
Alec
A
Roelke
Vihang
V
Mehta
Steve Y
SY
Rhieu
G Tayhas R
GT
Palmore
Domenico
D
Pacifici
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D005947:Glucose / Q000032:analysis*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D012834:Silver / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*
D012834:Silver; D005947:Glucose