The spectrum of morphology in non-neoplastic prostate including cancer mimics.
The spectrum of morphology in non-neoplastic prostate includes lesions of prostatic epithelial origin, the most common being atrophy, including partial atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia and crowded benign glands, as well as those of non-prostatic origin, such as seminal vesicle epithelium. These lesions often mimic lower-grade prostatic adenocarcinoma whereas others, such as granulomatous prostatitis, for example, are in the differential diagnosis of adenocarcinoma, Gleason grades 4 or 5. Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy.
Section of Pathological Anatomy, Polytechnic University of Marche Region, School of Medicine, United Hospitals, Ancona, Italy. r.montironi@univpm.it
Rodolfo
R
Montironi
Marina
M
Scarpelli
Roberta
R
Mazzucchelli
Liang
L
Cheng
Antonio
A
Lopez-Beltran
D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology*; D011467:Prostate / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology
D014408:Biomarkers, Tumor