The influence of selected hypotensive drugs on the bioavailability of minerals from buckwheat groats in vitro enzymatic digestion.
BACKGROUND
The mineral status in hypertensive patients may be affected by hypotensive drugs. The aim of this study was to estimate the influence of hypotensive drugs (angiotensine converting enzyme inhibitors (ACE-I), β-blockers, Ca-antagonists, diuretics) on the potential bioavailability of magnesium, iron, zinc and copper from buckwheat groats in vitro enzymatic digestion.


METHODS
The degree of release of magnesium, iron, zinc and copper from buckwheat groats was determined with and without (the control sample) an addition of hypotensive drugs. Four antihypertensive drugs in one dose (one tablet per sample) were analysed: metocard (a β-blocker), cardilopin (a Ca-antagonist), apo-perindox (ACE-I) and indapen (a diuretic). The samples were subjected to enzymatic digestion under in vitro conditions. The content of minerals in buckwheat groats before and after enzymatic digestion was determined by flame atomic absorption spectrometry (AAS).


RESULTS
It was found that cardilopin (amlodipine) and indapen (indapamide) significantly increased the release of zinc from groats. The degree of release of magnesium was higher and the release of iron was lower in samples with apo-perindox (perindopril) than in the control group. The release of copper was significantly decreased by indapen (indapamid).


CONCLUSIONS
Amlodipine, perindopril and indapamide affected the release of magnesium, iron, zinc and copper from buckwheat groats in vitro enzymatic digestion.
Department of Hygiene and Human Nutrition, Poznań University of Life Sciences, Poznan, Poland. jsulibur@up.poznan.pl
Joanna
J
Suliburska
Paweł
P
Bogdański
Barbara
B
Chiniewicz
D017311:Amlodipine / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001682:Biological Availability; D003300:Copper / Q000493:pharmacokinetics; D004063:Digestion; D019612:Fagopyrum / Q000737:chemistry*; D018565:Food-Drug Interactions; D007190:Indapamide / Q000494:pharmacology; D007501:Iron / Q000493:pharmacokinetics; D008274:Magnesium / Q000493:pharmacokinetics; D010194:Pancreatin / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D020913:Perindopril / Q000494:pharmacology; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000493:pharmacokinetics*; D015032:Zinc / Q000493:pharmacokinetics
D000959:Antihypertensive Agents; D014131:Trace Elements; D017311:Amlodipine; D003300:Copper; D010194:Pancreatin; D007501:Iron; D010434:Pepsin A; D007190:Indapamide; D008274:Magnesium; D015032:Zinc; D020913:Perindopril