Autologous chondrocyte implantation for knee cartilage injuries: moderate functional outcome and performance in patients with high-impact activities.
Few studies have assessed the results of autologous chondrocyte implantation in patients with high-impact activities. The purpose of this study was to evaluate the early functional outcome and activity level after 2-stage autologous chondrocyte implantation in professional soldiers and athletes. Nineteen patients with an average age of 32.2 years were treated with autologous chondrocyte implantation and followed up for a minimum of 2 years. All patients except 2 had received previous arthroscopic treatment with debridement and/or microfracture. The mean size of the postdebridement defect was 6.54 cm2. Using Novocart technology (B. Braun-Tetec, Reutlingen, Germany), periosteal patch and matrix-assisted autologous chondrocyte implantation was sequentially performed with no randomization. The average subjective knee evaluation score and Lysholm score improved from 39.16 and 42.42, respectively, preoperatively to 62.4 and 69.4, respectively, at latest follow-up. Median Tegner activity score was 8.8 before injury, 3.8 preoperatively, and 6.15 at latest follow-up. Second-look arthroscopy was performed in 11 patients due to persistent pain, decreased range of movement, and mechanical symptoms. Six of 19 (31.5%) patients with professional or recreational athletic activities returned to preinjury levels of athletic performance.This study shows that mid-term results with autologous chondrocyte implantation in high-performance patients are not as good as have been reported with other similar technologies. Motivational issues during prolonged rehabilitation, multiple surgical interventions before autologous chondrocyte implantation, patient age, and large defects can potentially influence the outcome and overall performance in this selected group of patients.
Department of Sports Medicine, University Hospital of Patras, Patras, Greece. andpan21@gmail.com
Andreas
A
Panagopoulos
Louw
L
van Niekerk
Ioannis
I
Triantafillopoulos
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D050724:Fractures, Cartilage / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D009043:Motor Activity; D020127:Recovery of Function; D016896:Treatment Outcome; D055815:Young Adult