Natural products as kinase inhibitors.
Natural products have been widely used to dissect the basic mechanisms of fundamental life science and as clinical therapeutics. Recently, there has been significant interest in discovering new chemical pharmacophores in natural products to fulfil the vast demand for novel kinase inhibitors and address critical unmet medical needs with respect to signal transduction pathways. In this review, we summarize the history of several different classes of natural product-derived kinase inhibitors, discuss their kinome-wide target profiles and examine their structural binding modes based on available 3D X-ray structures. In particular, their origin, target activity, selectivity, scope and potential therapeutic development are highlighted against the backdrop of medicinal chemistry.
High Magnetic Field laboratory, Chinese Academy of Sciences, P.O. Box 1110, Hefei, Anhui 230031, PR China.
Jing
J
Liu
Yi
Y
Hu
David L
DL
Waller
Junfeng
J
Wang
Qingsong
Q
Liu
D000730:Androstadienes / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000077191:Wortmannin
D000730:Androstadienes; D001688:Biological Products; D047428:Protein Kinase Inhibitors; D000077191:Wortmannin