Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.
Angiotensin II infusion in mice promotes abdominal and thoracic aortic aneurysms, which provides a feasible approach to study the mechanisms of these two distinct diseases.
Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.
Dennis
D
Bruemmer
Alan
A
Daugherty
Hong
H
Lu
Debra L
DL
Rateri
D000804:Angiotensin II / Q000633:toxicity*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000473:pathology*; D001014:Aortic Aneurysm / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D012084:Renin-Angiotensin System / Q000502:physiology; D013045:Species Specificity
D000804:Angiotensin II