Granuloma annulare photoinduced by paroxetine.
Granuloma annulare (GA) is a benign granulomatous skin disease with several clinical manifestations and characteristic histological findings. GA located in photoexposed areas is a rare finding and its association to a drug-induced systemic photosensitivity is even less common. To the best of our knowledge, only one case of systemic drug photosensitivity manifesting as a GA has been reported. We describe a patient with systemic photosensitivity to paroxetine with clinical and histological manifestations of GA, which was confirmed by the photobiological study. The phototest revealed a reduction of the minimal erythematous dose for UVB while taking the paroxetine and its normalization after its withdrawal, which was accompanied by the clinical resolution of the skin eruption. The manifestation of systemic drug photosensitivity as a GA like in our case is exceptional.
Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, A Coruña, Spain. adriana_alpe@hotmail.com
Adriana
A
Álvarez-Pérez
Silvia
S
Gómez-Bernal
Enrique
E
Gutiérrez-González
M Teresa
MT
Rodríguez-Granados
Jaime
J
Toribio
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D016460:Granuloma Annulare / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D017374:Paroxetine / Q000008:administration & dosage / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine