Diurnal rhythms are altered in a mouse model of multiple sclerosis.
Our earlier studies described a disruption of heart rate and blood pressure diurnal rhythms in mice with experimental autoimmune encephalomyelitis (EAE). The present study investigates whether these observations could be extended to additional clock-regulated rhythms in mice with EAE. Analysis of clock gene expression in the liver of EAE mice demonstrated significant variability associated with Per2 rhythmic expression. Corticosterone and leptin hormone rhythms were also altered in EAE mice. The results presented here indicate that disturbances in clock-regulated rhythms are associated with EAE and present a suitable model for investigating the relationship between circadian disruption and autoimmune inflammatory disease.
Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. buenafea@ohsu.edu
Abigail C
AC
Buenafe
D000818:Animals; D056926:CLOCK Proteins / Q000378:metabolism; D021081:Chronobiology Disorders / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000150:complications* / Q000209:etiology / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology*; D006023:Glycoproteins / Q000009:adverse effects; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000009:adverse effects; D056950:Period Circadian Proteins / Q000378:metabolism; D037342:Pertussis Toxin / Q000009:adverse effects; D013601:T-Lymphocytes / Q000378:metabolism; D013997:Time Factors
D006023:Glycoproteins; D020738:Leptin; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; C445081:myelin oligodendrocyte glycoprotein (35-55); D056926:CLOCK Proteins; C538944:Clock protein, mouse; D037342:Pertussis Toxin; D007041:Hypoxanthine Phosphoribosyltransferase; D003345:Corticosterone