Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine-threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
University of Stuttgart, Institute of Cell Biology and Immunology, Allmandring 31, 70569 Stuttgart, Germany. monilola.olayioye@izi.uni-stuttgart.de
Monilola A
MA
Olayioye
Angelika
A
Hausser
D000818:Animals; D001692:Biological Transport; D002518:Ceramides / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D022161:Transport Vesicles / Q000378:metabolism*
D002518:Ceramides; D008565:Membrane Proteins; D020033:Protein Isoforms; C119090:CERT1 protein, human; C089212:protein kinase D; D017346:Protein Serine-Threonine Kinases; D011493:Protein Kinase C