Vitamin D and incidence of diabetes: a prospective cohort study.
OBJECTIVE
To investigate the relationship between levels of 25-hydroxyvitamin D and the incidence of type 2 diabetes in a Spanish population.


METHODS
We undertook a population-based prospective study in a population from southern Spain. The first phase of the study (1996-1998) included 1226 individuals. Of this original cohort, 988 persons were reassessed in 2002-2004 and 961 in 2005-2007. Measurements were made of 25-hydroxyvitamin D and intact parathyroid hormone in 2002-2004 and an oral glucose tolerance test was done in three time points.


RESULTS
The incidence of diabetes in subjects with 25-hydroxyvitamin D levels ≤ 18.5 ng/mL (percentile 25) was 12.4% vs 4.7% in subjects with levels >18.5 ng/mL. The likelihood of having diabetes during the four years of follow-up was significantly lower in the subjects with higher levels of 25-hydroxyvitamin D [OR = 0.17 (0.05-0.61)]. None of the subjects with levels higher than 30 ng/mL developed diabetes.


CONCLUSIONS
In this prospective study, we found a significant inverse association between serum 25-hydroxyvitamin D levels and the risk for type 2 diabetes in a population from the south of Spain.
Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain. inmagonzalezmolero@hotmail.com
Inmaculada
I
González-Molero
Gemma
G
Rojo-Martínez
Sonsoles
S
Morcillo
Carolina
C
Gutiérrez-Repiso
Elehazara
E
Rubio-Martín
Maria Cruz
MC
Almaraz
Gabriel
G
Olveira
Federico
F
Soriguer
D000328:Adult; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010281:Parathyroid Hormone / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*; D014808:Vitamin D Deficiency / Q000453:epidemiology*; D014815:Vitamins
D001786:Blood Glucose; D010281:Parathyroid Hormone; D014815:Vitamins; D014807:Vitamin D