Childhood fibroblastic and myofibroblastic tumors: a multicenter documentation and review of the literature.
OBJECTIVE
In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/myofibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject.


METHODS
A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and myofibroblastic group according to World Health Organization criteria were collected.


RESULTS
The study comprised 407 soft tissue tumors in total. Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases) of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory myofibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. The only malignant case was an infantile fibrosarcoma.


CONCLUSIONS
Infantile fibrosarcoma was lower than reported series and a male predominance was noted. The low incidence of newly described entities as well suggests that these tumors may have been unrecognized.
Department of Pathology, Ankara Children's Hematology and Oncology Research and Training Hospital, Ankara, Turkey. ayperkacar@yahoo.com
Ayper
A
Kaçar
Irem
I
Paker
Diclehan
D
Orhan
Aylar
A
Poyraz
Aylin
A
Okçu Heper
Nilüfer
N
Arda
Esin
E
Boduroğlu
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D047708:Myofibroma / Q000473:pathology*; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000473:pathology*