Evaluation of bone mineral density in premenopausal women with type-2 diabetes mellitus in Zahedan, southeast Iran.
OBJECTIVE
To determine the BMD in premenopausal women with type-2 diabetes mellitus.


METHODS
This case-control study was performed on 60 premenopausal women with type-2 diabetes mellitus and 60 normal premenopausal subjects. The groups were not completely matched regarding BMI; but they were in the range of obesity. Bone mineral density was determined using dual energy X-ray absorptiometry (DXA) to define bone mineral density (BMD) in second to fourth lumbar vertebrae and the neck of the femur (g/cm2).


RESULTS
The results showed that BMD, T- and Z-score of femoral neck, total femur, L2, and Ward's were not significantly different between type 2 diabetic and normal premenopausal women (p > 0.5). A significant increase of L3 BMD and L2-L4 Z-score was observed in diabetic group (p < 0.05). In addition BMD, T- and Z-score of L4 were significantly higher in type 2 diabetic women than normal premenopausal women (P < 0.05).


CONCLUSIONS
Higher BMD was noted over the spine in diabetic group which may be due to higher BMI in this group.
Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Zahra
Z
Zakeri
Zohreh
Z
Azizi
Hamid
H
Mehrabifar
Mohammad
M
Hashemi
D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D017697:Premenopause