Antioxidative oligostilbenes from Caragana sinica.
Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC(50) values ranging from 34.7±1.0 to 89.1±2.3μM.
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
Qinghao
Q
Jin
Xiang Hua
XH
Han
Seong Su
SS
Hong
Chul
C
Lee
Sanggil
S
Choe
Dongho
D
Lee
Youngsoo
Y
Kim
Jin Tae
JT
Hong
Mi Kyeong
MK
Lee
Bang Yeon
BY
Hwang
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032602:Caragana / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D007189:Indans; D012118:Resorcinols; D013267:Stilbenes; C574449:caragasinin A