Molecular biology of brain tumors.
Much progress has been made in understanding the molecular genetics of brain tumors, especially gliomas.The development and use of high-throughput platforms that can interrogate molecular lesions on a variety of platforms will increase our ability to identify molecular subclasses of these tumors. Future challenges will include the development of methods to integrate these data among different platforms in order to identify optimal biomarkers and robust subclasses. The ultimate challenge, however, remains the translation of this biological knowledge into improved therapies for patients.
Department of Radiation Oncology, University of Texas-MD Anderson Cancer Center, Houston, TX, USA.
Jing
J
Li
Erik
E
Sulman
Kenneth
K
Aldape
D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics*; D005910:Glioma / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology