Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy.
We report the first case of Mycobacterium avium reactivation, after prolonged latency, in a HIV-infected patient receiving highly active antiretroviral therapy with undetectable viral replication and normal CD4 cell count. The patient presented with a painful swollen shoulder seven years after initial M. avium bacteriaemia. Articular puncture grew M. avium. The isolates of the first and second infection were identical using repetitive-sequence-based Polymerase Chain Reaction analyses.
Université Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Guillaume
G
Bussone
Florence
F
Brossier
Laurent
L
Roudiere
Emmanuelle
E
Bille
Nawal
N
Sekkal
Caroline
C
Charlier
Jacques
J
Gilquin
Fanny
F
Lanternier
Marc
M
Lecuit
Olivier
O
Lortholary
Emilie
E
Catherinot
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D004269:DNA, Bacterial / Q000235:genetics; D005838:Genotype; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D009164:Mycobacterium Infections; D009162:Mycobacterium avium / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011859:Radiography; D012008:Recurrence; D012782:Shoulder / Q000000981:diagnostic imaging / Q000473:pathology; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D019562:Viral Load
D004269:DNA, Bacterial