Mobile genetic elements and cancer. From mutations to gene therapy.
In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented. Events that lead to the activation of mobile elements in mammalian somatic cells, as well as the use of mobile elements in genetic screening and cancer gene therapy, are reviewed.
Taras Shevchenko Kyiv National University, Kyiv, Ukraine. iryna.kozeretska@gmail.com
I A
IA
Kozeretska
S V
SV
Demydov
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LI
Ostapchenko
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004251:DNA Transposable Elements; D020077:Endogenous Retroviruses / Q000235:genetics / Q000378:metabolism; D004777:Environment; D059647:Gene-Environment Interaction; D005820:Genetic Testing; D015316:Genetic Therapy; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*
D004251:DNA Transposable Elements