Top-down modulation: bridging selective attention and working memory.
Selective attention, the ability to focus our cognitive resources on information relevant to our goals, influences working memory (WM) performance. Indeed, attention and working memory are increasingly viewed as overlapping constructs. Here, we review recent evidence from human neurophysiological studies demonstrating that top-down modulation serves as a common neural mechanism underlying these two cognitive operations. The core features include activity modulation in stimulus-selective sensory cortices with concurrent engagement of prefrontal and parietal control regions that function as sources of top-down signals. Notably, top-down modulation is engaged during both stimulus-present and stimulus-absent stages of WM tasks; that is, expectation of an ensuing stimulus to be remembered, selection and encoding of stimuli, maintenance of relevant information in mind and memory retrieval.
Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA. adam.gazzaley@ucsf.edu
Adam
A
Gazzaley
Anna C
AC
Nobre
D001288:Attention / Q000502:physiology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term / Q000502:physiology*; D009434:Neural Pathways; D010296:Parietal Lobe / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology