Nurr1 haplotypes are associated with femoropopliteal restenosis/re-occlusion after percutaneous transluminal angioplasty.
Restenosis/re-occlusion remains a frequent complication in the first year after percutaneous transluminal angioplasty (PTA). In this study, association of nuclear receptor related 1 protein (Nurr1) haplotypes to the restenosis/re-occlusion rate after femoropopliteal PTA was investigated. Patients (n = 142) with disabling claudication or critical limb ischaemia, who had undergone technically successful femoropopliteal PTA, were prospectively followed up by vascular ultrasound imaging 12 months after the procedure. Nurr1 haplotypes 2 and 3 were associated significantly with the restenosis/re-occlusion rate (adjusted odds ratio 1.6, 95% confidence interval (CI) 1.1-2.3 and 2.0, 1.3-2.8, respectively) on univariate analysis.
Department of Vascular Diseases, University Medical Centre, Zaloska 7, Ljubljana, Slovenia.
M
M
Božič-Mijovski
M
M
Bedenčič
M
M
Stegnar
V
V
Salapura
M K
MK
Ježovnik
M
M
Kozak
A
A
Blinc
D000368:Aged; D017130:Angioplasty / Q000009:adverse effects*; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011150:Popliteal Artery / Q000000981:diagnostic imaging*; D012008:Recurrence; D012307:Risk Factors; D014463:Ultrasonography
C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2