Promising application of dynamic nuclear polarization for in vivo (13)C MR imaging.
Use of hyperpolarized (13)C in magnetic resonance (MR) imaging is a new technique that enhances signal tens of thousands-fold. Recent in vivo animal studies of metabolic imaging that used hyperpolarized (13)C demonstrated its potential in many applications for disease indication, metabolic profiling, and treatment monitoring. We review the basic physics for dynamic nuclear polarization (DNP) and in vivo studies reported in prostate cancer research, hepatocellular carcinoma research, diabetes and cardiac applications, brain metabolism, and treatment response as well as investigations of various DNP (13)C substrates.
Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA.
Yi-Fen
YF
Yen
Kiyoshi
K
Nagasawa
Tsutomu
T
Nakada
D000818:Animals; D001921:Brain / Q000378:metabolism; D002247:Carbon Isotopes; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism; D010825:Physics; D019275:Radiopharmaceuticals
D002247:Carbon Isotopes; D019275:Radiopharmaceuticals