Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.
In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.
Institute of Psychiatry, University of Bologna, Bologna, Italy. alessandro.serretti @ unibo.it
Alessandro
A
Serretti
Alberto
A
Chiesa
Concetta
C
Crisafulli
Isabelle
I
Massat
Sylvie
S
Linotte
Raffaella
R
Calati
Siegfried
S
Kasper
Ursula
U
Bailer
Yves
Y
Lecrubier
Martin
M
Fink
Irina
I
Antonijevic
Carlos
C
Forray
Lenore
L
Snyder
Joseph
J
Bollen
Joseph
J
Zohar
Diana
D
De Ronchi
Daniel
D
Souery
Julien
J
Mendlewicz
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018092:Kainic Acid Receptors / Q000235:genetics*; D012044:Regression Analysis; D016896:Treatment Outcome
D000928:Antidepressive Agents; D020962:Heterotrimeric GTP-Binding Proteins; D018092:Kainic Acid Receptors; C454420:G-protein beta3 subunit; C514872:GRIK4 protein, human