Malassezia globosa tends to grow actively in summer conditions more than other cutaneous Malassezia species.
Malassezia globosa is a major pathogen of Malassezia folliculitis (MF) and the predominant species on human skin. The aim of this study was to clarify the differences between M. globosa and other cutaneous Malassezia species, M. restricta, M. dermatis, M. sympodialis and M. furfur. The optimum growth temperature, effects of compounds of sweat and free fatty acids on growth, and lipase activities of five cutaneous Malassezia species were determined. The growth of M. globosa was promoted strongly by the compounds of sweat and high temperature unlike that of other cutaneous Malassezia species. This result clarified that M. globosa tended to grow actively in summer conditions more than other cutaneous Malassezia species. Furthermore, M. globosa showed high lipase activity. We consider these characteristics of M. globosa to relate to the pathogenesis of MF.
Departments of Dermatology Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. akaza.narifumi@menard.co.jp
Narifumi
N
Akaza
Hirohiko
H
Akamatsu
Shiori
S
Takeoka
Yasuyuki
Y
Sasaki
Hiroshi
H
Mizutani
Satoru
S
Nakata
Kayoko
K
Matsunaga
D003881:Dermatomycoses / Q000209:etiology* / Q000382:microbiology; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008290:Malassezia / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development* / Q000472:pathogenicity; D012621:Seasons; D013045:Species Specificity; D013542:Sweat / Q000737:chemistry / Q000382:microbiology; D013696:Temperature
D005230:Fatty Acids, Nonesterified; D008049:Lipase