Gd-DTPA-based MR-visible polymer for direct visualization of interventional devices.
We developed a Gd-DTPA (gadolinium(III)-diethylenetriaminepentaacetic acid)-based coating copolymer of hydrophilic and hydrophobic subunits to obtain visibility, hydrophilicity, and durability for passive visualization of catheters used in MR-guided interventions. We then examined a metal-free catheter coated with the polymer in a phantom and in porcine brain tissue ex vivo. Successful visualization of the coated device demonstrated the applicability of the new coating technique for visualizing catheters used in MR-guided interventions.
Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Yokohama, Japan. tomoka_kurita@terumo.co.jp
Tomoka
T
Kurita
Kagayaki
K
Kuroda
Takeo
T
Ohsaka
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002404:Catheterization; D020099:Coated Materials, Biocompatible; D003287:Contrast Media / Q000008:administration & dosage*; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation*; D019047:Phantoms, Imaging; D011108:Polymers; D013552:Swine
D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D011108:Polymers; D019786:Gadolinium DTPA