Increasing potential of HER3 signaling in colon cancer progression and therapy.
HER3 protein levels at the cancer cell plasma membrane are directly correlated with reduced survival in patients with colorectal cancer. In colorectal cancer cells, HER3 blockade restricted cellular growth (G(2)-M arrest), survival, migration, and invasion, and potentiated the chemotherapeutic effect of 5-FU, supporting strategies that target HER3 in subsets of patients with colorectal cancer.
Institut National de la Santé et de la Recherche Médicale U938, Paris 6 Université Pierre et Marie Curie, and Department of Molecular and Clinical Oncology, Hôpital Saint-Antoine, Paris, France. christian.gespach@inserm.fr
Christian
C
Gespach
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D020893:Receptor, ErbB-3 / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D020893:Receptor, ErbB-3