[Analysis of factors associated with changes in the oral glucose tolerance test, regardless of the values of fasting glucose].
OBJECTIVE
To identify factors associated with changes in oral glucose tolerance test (OGTT), regardless of fasting glucose (FG).


METHODS
377 patients (53.8 ± 15.2 years, 77.7% women and BMI = 31.4 ± 5.9 kg/m²) with no history of diabetes mellitus(DM), underwent OGTT and compared according to the results: normal (NGT), impaired (IGT) and DM.


RESULTS
202 patients (53.6%) had altered glucose tolerance: 69 with DM (18.3%) and 133 with IGT (35.3%). In multivariate analysis, factors regardless of FG that were associated (P < 0.05) with changes in the OGTT were age (DM = 58.7 ± 12.9; IGT = 56.7 ± 14.3; NGT = 49.6 ± 15.6 years), hypertension (DM = 69.6%; IGT = 63.9%; NGT = 43.4%), FG (DM = 111.9 ± 9.2; IGT = 103.5 ± 10.3; NGT = 96.6 ± 11.1 mg/dL), HbA1C (DM = 6.1 ± 0.7%; IGT = 6.1 ± 0.5%; NGT = 5.8 ± 0.4%), triglycerides (DM = 179.3 ± 169.9; IGT = 154.2 ± 84.1; NGT = 129.1 ± 71.9 mg/dL), HDL-c (DM =44.7 ± 9.2; IGT = 47.5 ± 12.3; NGT = 50.6 ± 13.4 mg/dL) and uric acid in women (DM = 5.3 ± 1.5; IGT = 5.3 ± 1.3; NGT = 4.7 ± 1.3 mg/dL).


CONCLUSIONS
Age, hypertension, elevated triglycerides, HbA1C, uric acid (in women) and low HDL-C are associated with changes in the OGTT patients with overweight / obesity, irrespective of FG.
Serviço de Endocrinologia, Hospital Felício Rocho, Belo Horizonte, MG, Brasil. marciowlauria@gmail.com
Marcio Weissheimer
MW
Lauria
Isabela Nacif Bastos
IN
Dias
Maria Marta Sarquis
MM
Soares
Giovana Vignoli
GV
Cordeiro
Victor Eurípedes
VE
Barbosa
Adauto Versiani
AV
Ramos
D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005215:Fasting / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis
D001786:Blood Glucose