The many roles of TOX in the immune system.
TOX is a member of an evolutionarily conserved DNA-binding protein family and is expressed in several immune-relevant cell subsets. Here, we review the key role of TOX in regulating development of CD4 T cells, natural killer cells and lymphoid tissue inducer cells, the latter responsible for the generation of lymph nodes. Although the exact molecular mechanism of action of TOX remains to be elucidated, the role of TOX in establishment of gene programs in the thymus and the potential of TOX as a regulator of E protein activity are discussed.
Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Parinaz
P
Aliahmad
Akop
A
Seksenyan
Jonathan
J
Kaye
D000818:Animals; D002454:Cell Differentiation; D006609:High Mobility Group Proteins / Q000276:immunology*; D006801:Humans; D007107:Immune System; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D006609:High Mobility Group Proteins