[Regulation of gene expression during spermatogenesis at transcriptional level].
Mammalian spermatogenesis is a highly complex cell division and differentiation process occurring in the seminiferous tubules of the testis. This processes are regulated at both transcriptional and post-transcriptional levels, any mistake in this process can lead to infertility. Unveiling the molecular mechanisms of spermatogenesis has important implications for exploring novel contraceptive approach and treatment of infertility. This review addresses recent progress towards understanding the regulation of androgen, estrogen and their receptors, transcription factors and chromatin-associated factors for spermatogenesis at transcriptional level.
National Research Institute for Family Planning, Beijing, China. zhangxiujun66@yahoo.com.cn
Xiu-Jun
XJ
Zhang
Mei-Ling
ML
Liu
Meng-Chun
MC
Jia
D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology; D013091:Spermatogenesis; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D014157:Transcription Factors