Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT.
The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect.
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Zhenguo
Z
Zhu
Guoyong
G
Wu
Huajiang
H
Wei
Hongqin
H
Yang
Yonghong
Y
He
Shusen
S
Xie
Qingliang
Q
Zhao
Xiao
X
Guo
D001940:Breast / Q000166:cytology* / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D055620:Optical Phenomena; D010539:Permeability; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*
D005947:Glucose