Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach.
The superfamily of G-protein-coupled receptors (GPCRs) is one of the largest mammalian protein families. It is involved in signal transduction and participates in the regulation of normal physiological function and pathological progression of a range of diseases. Recent studies have demonstrated that many aberrant GPCRs and their ligands are associated with tumorigenesis, angiogenesis and metastasis, which provides promising opportunities for drug discovery for cancer prevention and treatment. It is necessary to search for drug targets such as ligands of unknown GPCRs and better modulators of known GPCRs using high throughput screening approaches. Here, we review recent research advances in the identification of novel GPCRs and their protein interactions.
The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Jinhua
J
Wu
Na
N
Xie
Xia
X
Zhao
Edouard C
EC
Nice
Canhua
C
Huang
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D020869:Gene Expression Profiling; D023281:Genomics; D057166:High-Throughput Screening Assays; D006801:Humans; D058977:Molecular Sequence Annotation; D040901:Proteomics; D043562:Receptors, G-Protein-Coupled / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods
D043562:Receptors, G-Protein-Coupled