Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy.
Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.
Department of Chemistry, Texas A&M University, PO Box 30012, College Station, TX 77842-3012, USA. diaz@chem.tamu.edu
Agustín
A
Díaz
Vipin
V
Saxena
Julissa
J
González
Amanda
A
David
Barbara
B
Casañas
Carrie
C
Carpenter
James D
JD
Batteas
Jorge L
JL
Colón
Abraham
A
Clearfield
M Delwar
MD
Hussain
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D015040:Zirconium / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C027006:zirconium phosphate; D004317:Doxorubicin; D015040:Zirconium