Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae.
The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl(3)@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl(3)@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.
Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, Iran.
Yousef
Y
Fazaeli
Mostafa M
MM
Amini
Hamed
H
Ashourion
Homayoun
H
Heydari
Abbas
A
Majdabadi
Amir Reza
AR
Jalilian
Shamsozoha
S
Abolmaali
D000700:Analgesics / Q000008:administration & dosage / Q000138:chemical synthesis; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000008:administration & dosage*; D006801:Humans; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D016062:Porosity; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects*; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000138:chemical synthesis*
D000700:Analgesics; C509968:MCM-41; D053769:Nanocapsules; D006046:Gold; D012822:Silicon Dioxide