The clinical implications of increased cyclophilin A levels in patients with acute coronary syndromes.
BACKGROUND
Cyclophilin A is a secreted molecule that has a physiological and pathological role in cardiovascular diseases. However, limited information is available on the relationship between cyclophilin A concentration and acute coronary syndromes (ACS). We investigated whether cyclophilin A concentration is related to the stability of coronary atherosclerotic plaque in patients with ACS.


METHODS
This study included normal controls (n=50), patients with stable angina (SA) (n=60) and patients with ACS, including unstable angina (UA) (n=60) and acute myocardial infarction (AMI) (n=90). Serum soluble cyclophilin A, matrix metalloproteinase 9 (MMP-9), MMP-3 and C-reactive protein concentrations (CRP) were measured. All coronary stenosis were assessed by angiographic coronary stenosis morphology.


RESULTS
Serum cyclophilin A concentration in ACS (UA and AMI ) subjects were significantly higher than those in patients with SA and controls (p<0.05). Serum cyclophilin A correlated positively with serum MMP-3 and MMP-9 and CRP in ACS patients(r(1)=0.69, r(2)=0.52, r(3)=0.49 p<0.0001), but not in control. Furthermore, the increased cyclophilin A concentrations was associated with the number of complex coronary stenoses (r(1)=0.63, p<0.0001), but not smooth lesions or stenosis severity, in coronary artery disease patients. Logistic regression analysis also demonstrated that serum cyclophilin A concentration was an independent predictor factor for ACS( OR, 2.721, 95% CI 1.563-4.042, p=0.001).


CONCLUSIONS
Patients with ACS showed that increased concentrations of cyclophilin A may be a valuable marker for predicting the severity of ACS.
Department of Cardiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China. yanjinchuan@hotmail.com
Jinchuan
J
Yan
Xuan
X
Zang
Rui
R
Chen
Wei
W
Yuan
Jie
J
Gong
Cuiping
C
Wang
Ying
Y
Li
D054058:Acute Coronary Syndrome / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D021984:Cyclophilin A / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood
D002097:C-Reactive Protein; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; D021984:Cyclophilin A