Poorly differentiated neuroendocrine carcinoma of the seminal vesicle.
We describe an extremely rare case of poorly differentiated neuroendocrine carcinoma arising from the seminal vesicle. A 67-year-old man presented with a left humeral bone tumor resulting in a pathological fracture. Positron emission tomography scan disclosed a large pelvic tumor mimicking prostatic cancer invading into the seminal vesicle. Laboratory data showed an elevation of neuron-specific enolase, despite the normal prostate-specific antigen. Transrectal needle biopsy showed a poorly differentiated carcinoma of the right seminal vesicle and the metastasis of the pelvic lymph node. Immunohistochemical results were compatible with the features of neuroendocrine carcinoma; synaptophysin, chromogranin A and CD 56 were positive. The previously biopsied bone tumor was finally diagnosed as a metastasis. A systemic chemotherapy using etoposide and cisplatin failed. The patient died of cancer one-and-a-half years later.
Department of Urology, National Hospital Organization Osaka National Hospital, Osaka, Japan. yasunaga@onh.go.jp
Yutaka
Y
Yasunaga
Takafumi
T
Ueda
Yoshinori
Y
Kodama
Toshitsugu
T
Oka
D000368:Aged; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000556:secondary*; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000556:secondary*; D002454:Cell Differentiation; D017809:Fatal Outcome; D005834:Genital Neoplasms, Male / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D012669:Seminal Vesicles / Q000473:pathology*