Mycobacterium avium complex infection-related immune reconstitution inflammatory syndrome of the central nervous system in an HIV-infected patient: case report and review.
Disseminated Mycobacterium avium complex (MAC) infection involves the central nervous system (CNS) less frequently than tuberculosis, and MAC-related immune reconstitution inflammatory syndrome (IRIS) of the CNS in AIDS patients is even more rarely described. We report a case of MAC-related IRIS of the CNS in an HIV-infected patient who presented with meningoencephalitis and myelitis 2 months after discontinuation of antiMAC therapy, when he had achieved prolonged suppression of HIV replication and restoration of CD4 counts to >100 cells/μL for 1 year. Cases of MAC-related IRIS of the CNS reported in the literature are reviewed.
Department of Internal Medicine, Chia-Yi Christian Hospital, Chia-Yi City, Taiwan.
Yi-Chien
YC
Lee
Ching-Lan
CL
Lu
Chung-Chih
CC
Lai
Yu-Tzu
YT
Tseng
Hsin-Yun
HY
Sun
Chien-Ching
CC
Hung
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000139:chemically induced* / Q000175:diagnosis / Q000382:microbiology; D015269:Mycobacterium avium Complex / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D009187:Myelitis / Q000139:chemically induced* / Q000175:diagnosis / Q000382:microbiology; D019562:Viral Load; D055815:Young Adult
D019380:Anti-HIV Agents