Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study.
We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort.  Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide polymorphisms.  The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m(2), and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m(2)).  The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele.  The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P <0.01).  Thus, the rs10509291, rs7894483, and rs10823116 alleles were associated with a high BMI (> 23 Kg/m(2)) and with overweight in this non-diabetic Chinese population.
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Juan
J
Zheng
Lu-Lu
LL
Chen
Fangxi
F
Xiao
Xiang
X
Hu
Xiulin
X
Deng
Huiqing
H
Li
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*
C447939:SIRT1 protein, human; D056564:Sirtuin 1