Compressed sensing sodium MRI of cartilage at 7T: preliminary study.
Sodium MRI has been shown to be highly specific for glycosaminoglycan (GAG) content in articular cartilage, the loss of which is an early sign of osteoarthritis (OA). Quantitative sodium MRI techniques are therefore under development in order to detect and assess early biochemical degradation of cartilage, but due to low sodium NMR sensitivity and its low concentration, sodium images need long acquisition times (15-25 min) even at high magnetic fields and are typically of low resolution. In this preliminary study, we show that compressed sensing can be applied to reduce the acquisition time by a factor of 2 at 7 T without losing sodium quantification accuracy. Alternatively, the nonlinear reconstruction technique can be used to denoise fully-sampled images. We expect to even further reduce this acquisition time by using parallel imaging techniques combined with SNR-improved 3D sequences at 3T and 7 T.
Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Center for Biomedical Imaging, Radiology Department, New York University Langone Medical Center, New York, NY, USA.
Guillaume
G
Madelin
Gregory
G
Chang
Ricardo
R
Otazo
Alexej
A
Jerschow
Ravinder R
RR
Regatte
D000328:Adult; D000465:Algorithms; D002358:Cartilage, Articular / Q000033:anatomy & histology* / Q000737:chemistry*; D044962:Data Compression / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012964:Sodium / Q000032:analysis*; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods*
D012964:Sodium