Anogenital pseudotumoral herpes and HIV infection:  a new challenge for diagnosis and treatment.
HIV-infected patients may develop rare anogenital pseudotumoral herpes potentially mimicking epidermoid carcinoma. We assessed treatment in five new cases with a median follow-up of 3.3 years. Recurrence and clinical nucleoside analog resistance were observed in all patients. All drug treatments were only temporarily curative and clinical responses varied between patients and recurrences. Foscavir seemed to be the most appropriate second-line treatment and cidofovir or thalidomide should be considered as alternative treatments.
Dermatology Department, Cochin Hospital, APHP, Paris, France.
Julie
J
Di Lucca-Christment
Simon
S
Jacobelli
Ludivien
L
Gressier
Françoise
F
Plantier
Hélène
H
Laude
Flore
F
Rozenberg
Flore
F
Rosenberg
Jean-Pierre
JP
Morini
Alexiane
A
Dallot
Marie-Françoise
MF
Avril
Nicolas
N
Dupin
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D000077404:Cidofovir; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000821:virology*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000188:drug therapy*; D013792:Thalidomide / Q000627:therapeutic use; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000188:drug therapy
D000998:Antiviral Agents; D063065:Organophosphonates; D017245:Foscarnet; D013792:Thalidomide; D003596:Cytosine; D000077404:Cidofovir