Lipid-dependent protein sorting at the trans-Golgi network.
In eukaryotic cells, the trans-Golgi network serves as a sorting station for post-Golgi traffic. In addition to coat- and adaptor-mediated mechanisms, studies in mammalian epithelial cells and yeast have provided evidence for lipid-dependent protein sorting as a major delivery mechanism for cargo sorting to the cell surface. The mechanism for lipid-mediated sorting is the generation of raft platforms of sphingolipids, sterols and specific sets of cargo proteins by phase segregation in the TGN. Here, we review the evidence for such lipid-raft-based sorting at the TGN, as well as their involvement in the formation of TGN-to-PM transport carriers. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.
Michal A
MA
Surma
Christian
C
Klose
Kai
K
Simons
D002352:Carrier Proteins / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000502:physiology*; D021962:Membrane Microdomains; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013045:Species Specificity; D013107:Sphingolipids / Q000378:metabolism; D013261:Sterols / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism*; D021601:trans-Golgi Network / Q000378:metabolism*
D002352:Carrier Proteins; D008055:Lipids; D013107:Sphingolipids; D013261:Sterols