A novel t(8;13)(q21;q22) translocation in a pediatric lipoma.
Pediatric lipomas are rare and their etiology is unknown. As in adult lipomas, a segment of 12q13-q15 has been documented as a common chromosomal rearrangement region. Here, we report a pediatric lipoma case without rearrangement of 12q13-q15 but with an apparently balanced translocation involving chromosomes 8 and 13 [t(8;13)(q21;q22)] detected by routine cytogenetic analysis, and small deletions on 5q21.1 and 8q21.11 detected by array comparative genetic hybridization. The small deletion on 8q21.11 is possibly due to chromosomal instability at the breakpoint of the translocation.
Department of Hepatology, the First Hospital of Jilin University, Changchun, Jilin, PR China.
Jinglan
J
Jin
Junqi
J
Niu
Young-Mi
YM
Kim
Xianfu
X
Wang
David
D
Parham
Robert
R
Letton
Shibo
S
Li
Ji-Yun
JY
Lee
D002675:Child, Preschool; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D055028:Comparative Genomic Hybridization; D006801:Humans; D008067:Lipoma / Q000235:genetics*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D014178:Translocation, Genetic