Current status and future prospects for epigenetic psychopharmacology.
Mounting evidence suggest that epigenetic regulation of brain functions is important in the etiology of psychiatric disorders. These epigenetic regulatory mechanisms, such as DNA methylation and histone acetylation, are influenced by many pharmaceutical compounds including psychiatric drugs. It is therefore of interest to investigate how psychiatric drugs are of influence and what the potential is of new epigenetic drugs for psychiatric disorders. With this targeted review we summarize the current state of knowledge in order to provide insight in this developing field. Several traditional psychiatric drugs have been found to alter the epigenome and in a variety of animal studies, experimental compounds with epigenetic targets have been investigated as potential psychiatric drugs. After discussion of the most relevant epigenetic mechanisms we present the evidence for epigenetic effects for the most relevant classes of drugs.
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands. mboks@umcutrecht.nl
Marco P
MP
Boks
Noëlle M
NM
de Jong
Martien J H
MJ
Kas
Christiaan H
CH
Vinkers
Cathy
C
Fernandes
René S
RS
Kahn
Jonathan
J
Mill
Roel A
RA
Ophoff
D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000187:drug effects*; D042421:Histone Code / Q000187:drug effects; D006657:Histones / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D011600:Psychopharmacology / Q000639:trends
D006657:Histones