Inflammatory marker levels in obese adolescents with glucose intolerance: increased chitotriosidase activity.
OBJECTIVE
Existence of low grade persistent inflammation in obese children may increase the risk of metabolic and cardiovascular events. The aim was to determine whether glucose intolerance has an influence on inflammatory markers in obese adolescents.


METHODS
45 obese adolescents (mean BMI: 30.34±5.42 kg/m²) were grouped as normal or impaired glucose tolerance. IL-6 and CRP levels were analyzed by commercially available kits. Chitotriosidase activity was measured by a fluorescence method and neopterin levels were determined by ELISA. Data were expressed as mean±SD.


RESULTS
IL-6 and CRP levels were similar in the two groups. Serum neopterin levels were not different between the groups. The chitotriosidase activity was significantly higher in the IGT group than NGT (124.33±51.97 μmol/L/h vs 84.50±53.99 μmol/L/h, p=0.04).


CONCLUSIONS
Serum chitotriosidase activity is increased in obese adolescents with impaired glucose tolerance.
Ege University, School of Medicine, Department of Clinical Biochemistry, İzmir, Turkey. ckabaroglu@gmail.com
Ceyda
C
Kabaroğlu
Ece
E
Onur
Burcu
B
Barutçuoğlu
Bayram
B
Özhan
Soner
S
Erdinç
Ahmet
A
Var
Oya
O
Bayindir
Betül
B
Ersoy
D000293:Adolescent; D050197:Atherosclerosis / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D005260:Female; D018149:Glucose Intolerance / Q000150:complications*; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D019798:Neopterin / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D015854:Up-Regulation
D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D019798:Neopterin; D002097:C-Reactive Protein; D006596:Hexosaminidases; C086400:chitotriosidase