Alpha-adrenoceptor blocking drugs in asthma.
The effect of alpha-adrenoceptor blocking drug, thymoxamine alone and in combination with isoprenaline, was studied on the specific airways conductance (SGaw) in ten patients with extrinsic asthma. Thymoxamine when given together with isoprenaline produced significantly greater increase in SGaw as compared to improvement achieved with isoprenaline alone. It is suggested that the potentiation of isoprenaline induced bronchodilatation by thymoxamine is mediated by increased cyclic AMP formation in the bronchial smooth muscle.
Department of Respiratory Medicine, Western Infirmary, Glasgow.
K R
KR
Patel
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D013948:Moxisylyte / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
D000317:Adrenergic alpha-Antagonists; D000242:Cyclic AMP; D007545:Isoproterenol; D013948:Moxisylyte