Determination of water content by capillary gas chromatography coupled with thermal conductivity detection.
This article presents some experience obtained by applying capillary gas chromatography coupled with thermal conductivity detection (GC/TCD) to the determination of water in substances for pharmaceutical use. This technique represents a useful, orthogonal tool complementary to water determination methods based on volumetric or coulometric titration. It can also represent an alternative technique when such titrations are not applicable. This article presents the preliminary results obtained in a number of case studies where a GC/TCD procedure was applied in comparison with pharmacopoeial methods to substances with different water contents.
European Directorate for the Quality of Medicines & HealthCare, Council of Europe, Strasbourg, France.
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A
Lodi
M S
MS
Bellini
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A
Clavel
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Pijnenburg
D000658:Amoxicillin / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods; D002939:Ciprofloxacin / Q000031:analogs & derivatives / Q000032:analysis; D005062:European Union; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012997:Solvents; D000198:Spectinomycin / Q000032:analysis; D013806:Theophylline / Q000032:analysis; D013814:Thermal Conductivity; D014867:Water / Q000032:analysis*
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D012997:Solvents; D014867:Water; D002939:Ciprofloxacin; C047225:difloxacin; D000658:Amoxicillin; D000198:Spectinomycin; D013806:Theophylline