Severe necrotizing pneumonia complicating influenza A (H1N1): the role of immunologic interaction.
This report describes the successful management of a documented necrotizing pneumonia due to Streptococcus pneumoniae in a child with pandemic influenza A (H1N1). The importance of early recognition of bacterial superinfection in patients with influenza and the immunologic interactive mechanisms between viruses and bacteria in determining respiratory diseases are highlighted. The role of modern molecular techniques in improving diagnostic microbiology sensitivity and informing consequent clinical care is emphasized.
R
R
Guidi
P
P
Osimani
C
C
Azzari
M
M
Resti
F M
FM
De Benedictis
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology / Q000472:pathogenicity*; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D009336:Necrosis; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity*; D015163:Superinfection / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents