Prenylated isoflavonoids from Rhynchosia edulis.
Four new prenylated isoflavones, rhynedulins A-C (1-3) and rhynedulinal (4), were isolated by bioassay-guided fractionation of the dichloromethane bark extract of Rhynchosia edulis. Five previously described compounds, scandenal, ulexin B, cajanone, cajanin, and cyclochandalone, were also isolated. These isoflavonoids showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei. They also have weak antiproliferative activity towards MCF-7 cells.
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA.
Ifedayo V
IV
Ogungbe
Gabrielle M
GM
Hill
Rebecca A
RA
Crouch
Bernhard
B
Vogler
Meenakshi
M
Nagarkoti
William A
WA
Haber
William N
WN
Setzer
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D045744:Cell Line, Tumor; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D014344:Trypanocidal Agents / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones; D010936:Plant Extracts; D014344:Trypanocidal Agents; D003546:Cysteine Endopeptidases; C446033:rhodesain