OA in 2011: Age-related OA--a concept emerging from infancy?
That primary osteoarthritis (OA) is an age-related disorder is undoubted, but how aging contributes to OA is poorly understood. New insights from 2011 offer potential explanations, novel models for study, and the suggestion that a deeper understanding of what 'aging' actually is might pave the way to everlasting joints.
Institute of Pathology, Medical Center Coburg, Ketschendorferstraße 33, 96450 Coburg, Germany. thomas.aigner@klinikum-coburg.de
Thomas
T
Aigner
Wiltrud
W
Richter
D000375:Aging / Q000473:pathology* / Q000502:physiology; D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death; D016922:Cellular Senescence / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007596:Joints / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D010003:Osteoarthritis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress