Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured             human skin keratinocytes.
Ultraviolet (UV) radiation plays an important role in the pathogenesis of             skin photoaging. Depending on the wavelength of UV, the epidermis is affected             primarily by UVB. One major characteristic of photoaging is the dehydration of             the skin. Membrane-inserted water channels (aquaporins) are involved in this process.             In this study we demonstrated that UVB radiation induced aquaporin-3 (AQP3) down-regulation             in cultured human skin keratinocytes. Kanglaite is a mixture consisting of extractions             of Coix Seed, which is an effective anti-neoplastic agent and can inhibit the             activities of protein kinase C and NF-κB. We demonstrated that Kanglaite inhibited             UVB-induced AQP3 down-regulation of cultured human skin keratinocytes. Our findings             provide a potential new agent for anti-photoaging. The related molecular mechanisms             remain to be further elucidated.
Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, PR China.
Shi-Jun
SJ
Shan
Ting
T
Xiao
John
J
Chen
Shi-Ling
SL
Geng
Chang-Ping
CP
Li
Xuegang
X
Xu
Yuxiao
Y
Hong
Chao
C
Ji
Ying
Y
Guo
Huachen
H
Wei
Wei
W
Liu
Dapeng
D
Li
Hong-Duo
HD
Chen
D000970:Antineoplastic Agents / Q000494:pharmacology; D051400:Aquaporin 3 / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D031742:Coix / Q000737:chemistry; D015536:Down-Regulation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000528:radiation effects*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D012639:Seeds / Q000737:chemistry; D012867:Skin / Q000166:cytology; D014466:Ultraviolet Rays / Q000009:adverse effects*
C496027:AQP3 protein, human; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D010936:Plant Extracts; D051400:Aquaporin 3; D011493:Protein Kinase C; C499781:kang-lai-te