Dnmt3a silences hematopoietic stem cell self-renewal.
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA. trowbridge@bloodgroup.tch.harvard.edu
Jennifer J
JJ
Trowbridge
Stuart H
SH
Orkin
D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D034622:RNA Interference
D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A