Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82.
G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic loci with signatures of recent selection in humans contain GPCR genes among them the X-chromosomally located gene for GPR82. This gene encodes a so-called orphan GPCR with unknown function. To address the functional relevance of GPR82 gene-deficient mice were characterized. GPR82-deficient mice were viable, reproduced normally, and showed no gross anatomical abnormalities. However, GPR82-deficient mice have a reduced body weight and body fat content associated with a lower food intake. Moreover, GPR82-deficient mice showed decreased serum triacylglyceride levels, increased insulin sensitivity and glucose tolerance, most pronounced under Western diet. Because there were no differences in respiratory and metabolic rates between wild-type and GPR82-deficient mice our data suggest that GPR82 function influences food intake and, therefore, energy and body weight balance. GPR82 may represent a thrifty gene most probably representing an advantage during human expansion into new environments.
Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.
Kathrin M Y
KM
Engel
Kristin
K
Schröck
Daniel
D
Teupser
Lesca Miriam
LM
Holdt
Anke
A
Tönjes
Matthias
M
Kern
Kerstin
K
Dietrich
Peter
P
Kovacs
Ute
U
Krügel
Holger A
HA
Scheidt
Jürgen
J
Schiller
Daniel
D
Huster
Gudrun A
GA
Brockmann
Martin
M
Augustin
Joachim
J
Thiery
Matthias
M
Blüher
Michael
M
Stumvoll
Torsten
T
Schöneberg
Angela
A
Schulz
D000818:Animals; D001835:Body Weight; D004032:Diet; D005247:Feeding Behavior; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D014960:X Chromosome
D043562:Receptors, G-Protein-Coupled; D014280:Triglycerides