A single-bout of one-hour spinning exercise increases troponin T in healthy subjects.
OBJECTIVE
While long-term endurance exercise is known to increase cardiac biomarkers, only a few studies on short-term exercise and these markers have been reported. The aim of this study was to investigate the acute effects of a one-hour bicycle spinning on cardiac biomarkers in healthy individuals.


METHODS
Serum levels of high-sensitive troponin T (TnT), creatinine kinase MB fraction (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatinine kinase (CK) and myoglobin were measured at baseline, 1 and 24 hour after one hour of spinning exercise in ten healthy and fit (age 31.0 ± 6.6 years) individuals.


RESULTS
TnT doubled one hour post-exercise (All values ≤ 5 - 9.7 ± 6.0 ng/L, p < 0.001). Two individuals had TnT levels above upper reference limit, URL (20.7 and 20.2 ng/L, URL = 12 ng/L). Myoglobin levels increased 72% one hour post-exercise (38 ± 20 - 66 ± 41 mg/L, p < 0.02). TnT and myoglobin levels returned to baseline 24 hour post-exercise. Serum levels of CK-MB, NT-proBNP and CK were not significantly changed.


CONCLUSIONS
A single-bout of one-hour bicycle spinning transiently increases TnT and myoglobin in healthy subjects. Some subjects even have TnT release above URL. Thus, recently performed exercise also of short duration should be taken into consideration in the evaluation of acute chest pain with release of cardiac TnT.
Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden. smita.dutta-roy@vgregion.se
Smita
S
Duttaroy
Daniel
D
Thorell
Lena
L
Karlsson
Mats
M
Börjesson
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D012680:Sensitivity and Specificity; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
D015415:Biomarkers; D009211:Myoglobin; D011498:Protein Precursors; D020107:Troponin T; C063382:prepro-brain natriuretic peptide; D020097:Natriuretic Peptide, Brain; D003404:Creatinine