Update on the epidermal differentiation complex.
On human chromosome 1q21, a 2-Mb region called the epidermal differentiation complex comprises many genes encoding structural and regulatory proteins that are of crucial importance for keratinocyte differentiation and stratum corneum properties. Apart from those for involucrin and loricrin, most of the genes are organized in four families: the genes encoding EF-hand calcium-binding proteins of the S100A family, the genes encoding the small proline rich proteins (SPRRs) and the late cornified envelope (LCE) proteins, two families of cornified cell envelope components, and the genes encoding the S100-fused type proteins (SFTPs). This review focuses on the SPRRs, LCE proteins and SFTPs. It describes their structures, their specific functions and, when known, the mechanisms involved in the regulation of their expression. It also highlights their possible involvement in skin diseases.
UMR5165 CNRS, U1056 INSERM, Toulouse, France.
Julie
J
Henry
Eve
E
Toulza
Chiung-Yueh
CY
Hsu
Laurence
L
Pellerin
Stefana
S
Balica
Juliette
J
Mazereeuw-Hautier
Carle
C
Paul
Guy
G
Serre
Nathalie
N
Jonca
Michel
M
Simon
D000595:Amino Acid Sequence; D002454:Cell Differentiation; D055233:Cornified Envelope Proline-Rich Proteins / Q000737:chemistry / Q000378:metabolism; D000078404:Epidermal Cells; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid
D055233:Cornified Envelope Proline-Rich Proteins