Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs.
Bioadhesive buccal films are innovative dosage forms with the ability to adhere to the mucosal surface and subsequently hydrate to release and deliver drugs across the buccal membrane. This study aims to formulate and characterize stable carrageenan (CAR) based buccal films with desirable drug loading capacity. The films were prepared using CAR, poloxamer (POL) 407, various grades of PEG (plasticizer) and loaded with paracetamol (PM) and indomethacin (IND) as model soluble and insoluble drugs, respectively. The films were characterized by texture analysis, thermogravimetric analysis (TGA), DSC, scanning electron microscopy, X-ray powder diffraction (XRPD), and in vitro drug release studies. Optimized films were obtained from aqueous gels comprising 2.5% w/w κ-CAR 911, 4% w/w POL 407 and 6% w/w (PM) and 6.5% w/w (IND) of PEG 600 with maximum drug loading of 1.6% w/w and 0.8 % w/w for PM and IND, respectively. TGA showed residual water content of approximately 5% of films dry weight. DSC revealed a T(g) at 22.25 and 30.77°C for PM and IND, respectively, implying the presence of amorphous forms of both drugs which was confirmed by XRPD. Drug dissolution profiles in simulated saliva showed cumulative percent release of up to 45 and 57% of PM and IND, respectively, within 40 min of contact with dissolution medium simulating saliva.
Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham Maritime, Kent, UK.
Farnoosh
F
Kianfar
Babur Z
BZ
Chowdhry
Milan D
MD
Antonijevic
Joshua S
JS
Boateng
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002351:Carrageenan / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009061:Mouth Mucosa / Q000378:metabolism*; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012463:Saliva / Q000378:metabolism; D012995:Solubility; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods
D004304:Dosage Forms; D014867:Water; D020442:Poloxamer; D000082:Acetaminophen; D011092:Polyethylene Glycols; D002351:Carrageenan; D007213:Indomethacin