Glycomics, glycoproteomics and the immune system.
Glycomics and glycoproteomics have become indispensible tools in the study of glycoconjugates. Mass spectrometry based methods are standardly used to study the proteome and/or glycome and these approaches are capable of providing both, qualitative and quantitative information using top down techniques. The human immune system marks a particular area of interest for glycomics and glycoproteomics research since a large number of key proteins in innate and adaptive immunity are glycoproteins. In numerous examples, the crucial influence of glycosylation on critical steps such as receptor interaction and binding has been demonstrated. In this review, we focus on different glycomics and glycoproteomics approaches and their application for studying protein glycosylation in the immune system.
Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany.
Daniel
D
Kolarich
Bernd
B
Lepenies
Peter H
PH
Seeberger
D000818:Animals; D054794:Glycomics / Q000379:methods*; D006031:Glycosylation; D006801:Humans; D007107:Immune System; D007136:Immunoglobulins / Q000032:analysis; D040901:Proteomics / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization
D007136:Immunoglobulins