[Vitamin D and autoimmunity. Second part: Clinical aspects].
Vitamin D is often confined to its role in calcium homeostasis and bone metabolism. An exponential literature discusses its non-skeletal effects, especially its central role in the physiology of the immune system, where it acts at several levels to maintain self-tolerance. Here, the authors review the experimental, epidemiological and clinical studies, illustrating the potential role of vitamin D in the development and perpetuation of autoimmune diseases such as systemic lupus erythematosus, type 1 diabetes mellitus, multiple sclerosis, inflammatory bowel diseases or rheumatoid arthritis.
Service de médecine interne, université Versailles-Saint-Quentin-en-Yvelines, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France. y.schoindre@hopital-foch.org
Y
Y
Schoindre
B
B
Terrier
J-E
JE
Kahn
D
D
Saadoun
J-C
JC
Souberbielle
O
O
Benveniste
Z
Z
Amoura
J-C
JC
Piette
P
P
Cacoub
N
N
Costedoat-Chalumeau
D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D019317:Evidence-Based Medicine; D006706:Homeostasis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D014807:Vitamin D / Q000276:immunology*; D014808:Vitamin D Deficiency / Q000276:immunology
D014807:Vitamin D