Recent advances on tea polyphenols.
Over the past decade many scientific and medical studies have focused on green tea for its long-purported health benefits. There is convincing evidence that tea is a cup of life. It has multiple preventive and therapeutic effects. This review thus focuses on the recent advances of tea polyphenols and their applications in the prevention and treatment of human cancers. Of the various polyphenols in tea, (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant, and active compound studied in tea research. EGCG inhibits several molecular targets to inhibit cancer initiation and modulates several essential survival pathways to block cancer progression. Herein, we describe the various mechanisms of action of EGCG and also discuss previous and current ongoing clinical trials of EGCG and green tea polyphenols in different cancer types.
The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
Jyoti
J
Kanwar
Mujtaba
M
Taskeen
Imthiyaz
I
Mohammad
Congde
C
Huo
Tak Hang
TH
Chan
Qing Ping
QP
Dou
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology; D002986:Clinical Trials as Topic; D006801:Humans; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D059808:Polyphenols; D013662:Tea