Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.
C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via π-stacking interactions.
University of Maryland, College Park, MD 20742, USA.
Ilana
I
Kelsey
Shizuka
S
Nakayama
Herman O
HO
Sintim
D000578:Amidines / Q000737:chemistry*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000737:chemistry; D054856:G-Quadruplexes; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D000578:Amidines; D007097:Imines; D014867:Water; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP