Function of the INO80 chromatin remodeling complex in DNA replication.
ATP-dependent chromatin remodeling complexes are involved in several nuclear processes. In particular the INO80 remodeling complex is an essential factor during transcription and DNA repair. Recently, several labs have described a novel role for INO80 during DNA replication. Moreover, Falbo et al. have presented evidence linking INO80's activities to the DNA damage tolerance pathways during replication (1). In this review we will discuss and integrate the results obtain by these various research groups to describe a novel role for INO80 in DNA replication.
Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, Texas 78957, USA.
Karina B
KB
Falbo
Xuetong
X
Shen
D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D004249:DNA Damage; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000096:biosynthesis; D005800:Genes, Fungal; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D004271:DNA, Fungal; C483404:INO80 complex, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins