Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles.
We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062, PR China.
Yun-Lin
YL
Liu
Jian
J
Zhou
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D007211:Indoles; D058115:Lewis Bases; D009584:Nitrogen