Histopathological aspects and local implications of oxidative stress in patients with oral lichen planus.
Aerobic life is connected with continuous production of free radicals, particularly reactive oxygen species (ROS). Cells posses an enzymatic and non-enzymatic antioxidant system to maintain redox homeostasis. Oxidant-antioxidant imbalance resulting in excessive accumulation of ROS is defined as oxidative stress. Oral lichen planus (OLP) is a chronic inflammation of unknown etiology. Several researchers suggest that oxidative stress is implicated in the pathogenesis of this disorder. The aim of this study was to evaluate the histopathological alterations and the status of local oxidative stress and antioxidant defense system in patients with OLP. We evaluated and compared the local levels of oxidative stress biomarkers malondialdehyde (MDA) and glutathione (GSH) in patients with OLP with that of normal controls. Increased levels of MDA and decreased levels of GSH suggest the idea of oxidative stress implication in the pathogenesis of oral lichen planus.
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Romania. ioana_scrobota@yahoo.com
Ioana
I
Scrobotă
Teodora
T
Mocan
C
C
Cătoi
P
P
Bolfă
Adriana
A
Mureşan
G
G
Băciuţ
D000328:Adult; D016022:Case-Control Studies; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism / Q000473:pathology*; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress
D008315:Malondialdehyde; D005978:Glutathione