Serotonin gene polymorphisms and psychiatry comorbidities in temporal lobe epilepsy.
OBJECTIVE
Neuropsychiatric comorbidities are frequent in temporal lobe epilepsy (TLE). It is biologically plausible that alterations in serotonin-related genes may be involved in higher susceptibility to psychiatric disease in these individuals. Here we report results of an association study of serotonin gene polymorphisms and psychiatry comorbidities in TLE.


METHODS
Case-control study of 155 patients with temporal lobe epilepsy. We evaluate the influence of 5-HTTLPR and 5-HTTVNTR polymorphisms in the 5-HTT gene and the C-1019G polymorphism in the 5-HT1A gene in psychiatric comorbidities of TLE.


RESULTS
After logistic regression, female sex (OR=2.34; 95% CI 1.06-5.17; p=0.035) and the presence of C allele of 5-HT1A C-1019G polymorphism (OR=2.77; 95% CI 1.01-7.63; p=0.048) remained independent risk factors for anxiety disorders in temporal lobe epilepsy.


CONCLUSIONS
C allele of 5-HT1A C-1019G polymorphism might be an independent risk factor for anxiety disorders in temporal lobe epilepsy. We believe that other studies in this venue will shade some light on molecular mechanisms involved in psychiatric comorbidities in epilepsy.
Medical Genetics Service, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.
Laila Cigana
LC
Schenkel
José Augusto
JA
Bragatti
Juliana Allebrand
JA
Becker
Carolina Machado
CM
Torres
Kelin Cristine
KC
Martin
Ana Claudia
AC
de Souza
Gisele Gus
GG
Manfro
Sandra
S
Leistner-Segal
Marino Muxfeldt
MM
Bianchin
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012189:Retrospective Studies
D044282:Receptor, Serotonin, 5-HT1A