Glycine passivated Fe3O4 nanoparticles for thermal therapy.
We demonstrate a single-step facile approach for the synthesis of glycine (amino acid) passivated Fe(3)O(4) magnetic nanoparticles (GMNPs) using soft chemical route. The surface passivation of Fe(3)O(4) nanoparticles with glycine molecules was evident from infrared spectroscopy, thermal and elemental analyses, and light scattering measurements. These nanoparticles show better colloidal stability, good magnetization, excellent self-heating capacity under external AC magnetic field and cytocompatibility with cell lines. Further, the active functional groups (-NH(2)) present on the surface of Fe(3)O(4) nanoparticles can be accessible for routine conjugation of biomolecules/biolabelling through well-developed bioconjugation chemistry. Specifically, a new colloidal glycine passivated biocompatible Fe(3)O(4) nanoparticles with excellent specific absorption rate (SAR) have been fabricated, which can be used as an effective heating source for hyperthermia treatment of cancer (thermal therapy).
Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India.
K C
KC
Barick
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Hassan
D000818:Animals; D002460:Cell Line; D005290:Ferric Compounds / Q000737:chemistry* / Q000627:therapeutic use*; D005998:Glycine / Q000737:chemistry* / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure
D005290:Ferric Compounds; C000499:ferric oxide; D005998:Glycine