Parameters of glycemic control and their relationship with zinc concentrations in blood and with superoxide dismutase enzyme activity in type 2 diabetes patients.
OBJECTIVE
This study assessed the relationship between the parameters of glycemic control, and zinc concentrations in blood and superoxide dismutase enzyme activity in type 2 diabetes patients.


METHODS
Seventy-three individuals, aged between 25 and 59 years, were divided into the experimental group (type 2 diabetes patients, n = 36) and control group (n = 37). Plasma and erythrocyte zinc concentrations, superoxide dismutase activity, and parameters of glycemic control were analyzed.


RESULTS
Mean plasma zinc concentration was 74.1 ± 10.7 µg/dL and 68.8 ± 9.6 µg/dL, erythrocyte zinc concentration was 48.1 ± 9.5 µg/gHb and 41.2 ± 8.0 µg/gHb, and superoxide dismutase activity was 2248.9 ± 300.0 U/gHb and 2059.6 ± 285.4 U/gHb, in the experimental group and the control group, respectively (p < 0.05).


CONCLUSIONS
Type 2 diabetes patients showed a positive response to oxidative stress due to adequate zinc concentration in blood and increased activity of superoxide dismutase, and the enzyme was influenced by serum insulin.
Department of Nutrition, Universidade Federal do Piauí, Teresina, PI, Brazil.
Vanessa Batista de Sousa
VB
Lima
Fabiane de Araújo
Fde A
Sampaio
Daila Leite Chaves
DL
Bezerra
José Machado
JM
Moita Neto
Dilina do Nascimento
Ddo N
Marreiro
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D015032:Zinc / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D013482:Superoxide Dismutase; D015032:Zinc