Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus.
Progressive multifocal leukoencephalopathy is a neurological infectious disease caused by the John Cunningham polyomavirus (JCV), an opportunistic agent with worldwide distribution. This disease is frequently seen in immunosuppressed patients and rarely associated with systemic lupus erythematosus. In the central nervous system PML demyelinating lesions occur in the supratentorial compartment. The authors describe a rare case of PML secondary to SLE treatment with atypical presentation restricted to the posterior fossa.
Montreal General Hospital, McGill University Health Center, 1650 Cedar Avenue, Montreal, QC, Canada. goncalves.neuroradio@gmail.com
Fabrício Guimarães
FG
Gonçalves
Leslie
L
Lamb
Raquel
R
Del Carpio-O'Donovan
D003388:Cranial Fossa, Posterior; D006801:Humans; D016867:Immunocompromised Host; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed