The need for littermate controls.
The dramatic increase in the amount of research data being produced necessarily leads to higher demands on statistical thresholds and on experimental planning. This is to avoid positive selection of multiple tested data. Here we would like to highlight the need for including littermate controls in animal experiments, in particular when genetically modified strains are analysed for quantitative phenotypes. Thus, this suggestion will have impact on most immunological experiments performed today.
Karolinska Institutet, Stockholm, Sweden. rikard.holmdahl@ki.se
Rikard
R
Holmdahl
Bernard
B
Malissen
D032761:Animal Experimentation / Q000592:standards*; D000818:Animals; D030801:Animals, Genetically Modified; D035061:Control Groups; D051379:Mice; D012107:Research Design / Q000592:standards*