Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.
A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.
Division of Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India.
Vemula
V
Praveen Kumar
R
R
Gajendra Reddy
Duc Duy
DD
Vo
Sumana
S
Chakravarty
Srivari
S
Chandrasekhar
René
R
Grée
D000818:Animals; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D007150:Immunohistochemistry; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009414:Nerve Growth Factors; D016501:Neurites / Q000187:drug effects*; D055495:Neurogenesis / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D000498:Allyl Compounds; D010636:Phenols
D001713:Biphenyl Compounds; D017705:Lignans; D009414:Nerve Growth Factors; D054852:Small Molecule Libraries; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols