The research strategies for probing the function of long noncoding RNAs.
Long noncoding RNAs (lncRNAs) represent a new frontier in molecular genetics and molecular biology. They have a tremendous potential for advancing our comprehensive understanding of biological processes in huma n health and disease. The transcripts of lncRNAs are easy to find, but sorting out what they do remains the biggest challenge in lncRNAs' research field. In the paper, we highlight recent progress regarding the methods to explore the roles of lncRNAs.
Key laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Agriculture, Shanghai Ocean University, Shanghai 201306, China. yanbiao1982@hotmail.com
Biao
B
Yan
Zhen-Hua
ZH
Wang
Jin-Tao
JT
Guo
D000818:Animals; D019295:Computational Biology; D020869:Gene Expression Profiling; D006801:Humans; D047468:Immunoprecipitation; D017404:In Situ Hybridization, Fluorescence; D058977:Molecular Sequence Annotation; D020411:Oligonucleotide Array Sequence Analysis; D009841:Oligonucleotides / Q000737:chemistry; D011485:Protein Binding; D034622:RNA Interference; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016601:RNA-Binding Proteins / Q000737:chemistry; D060888:Real-Time Polymerase Chain Reaction
D009841:Oligonucleotides; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins; C477371:locked nucleic acid