[NDM-1: the superbug?].
A novel type of carbapenemase, New Delhi metallo beta-lactamase 1 (NDM 1), was first identified in 2008 in two Enterobacteriacea isolates, both recovered from a Swedish patient transferred from India. The emergence of NDM 1 is now reported from all continents, often in patients with a history of travel or hospitalization in the Indian subcontinent. The NDM 1 producing Gram-negative bacteria are mainly Enterobacteriaceae, which can cause colonization or fatal infections, with worrying antimicrobial susceptibility profiles: some isolates have developed resistance to practically all available antibiotics. Is the NDM-1 the super-bug? Are we in the post-antibiotic era? This review is a summary of currently available knowledge of NDM-1 that draws attention to future antimicrobial resistance scenarios.
Dipartimento di Epidemiologia e Ricerca Preclinica, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Roma, Italy.
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D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002081:Buttocks; D003091:Colistin / Q000494:pharmacology / Q000627:therapeutic use*; D048909:Diabetes Complications; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007194:India; D007710:Klebsiella Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013548:Sweden; D014195:Travel; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D003091:Colistin