[Potential use of parathyroid hormone (PTH) in the treatments for oral diseases].
Bone formation is the key for successful dental treatments including periodontal tissue regeneration osseointegration of implant placement in which new alveolar bone formation is mandatory. Parathyroid hormone (PTH) is a peptide hormone containing 84 amino acids. Accumulated results show that intermittent PTH administration increases bone mass. Accordingly, recombinant N-terminal fragment of human PTH (1-34) , Teriparatide, is used for the treatments of osteoporosis worldwide. It is, therefore, expected that PTH has the potential to be a new therapeutic intervention for oral diseases that require increased bone remodeling and new bone formation.
Department of Biochemistry, Osaka University Graduate School of Dentistry, Japan.
Soichi
S
Tanaka
Kenji
K
Hata
Toshiyuki
T
Yoneda
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000188:drug therapy; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016723:Bone Remodeling / Q000187:drug effects; D015921:Dental Implants; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010281:Parathyroid Hormone / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*; D013268:Stimulation, Chemical; D009057:Stomatognathic Diseases / Q000188:drug therapy*; D019379:Teriparatide / Q000494:pharmacology / Q000627:therapeutic use*; D060449:Wnt Signaling Pathway / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D005819:Genetic Markers; D010281:Parathyroid Hormone; C422903:SOST protein, human; D019379:Teriparatide; D007334:Insulin-Like Growth Factor I