[Squamous cell carcinoma of the anal canal showing pathological complete response after S-1 plus radiotherapy -a case report].
The patient was a 53-year-old woman who underwent colonoscopy for anal pain and melena. We diagnosed her with Stage I (T2N0M0) anal canal squamous cell carcinoma by biopsy specimen and CT scan. We recommended chemo-radiotherapy because she hoped to keep her anus. For this patient, we planned an S-1 administration at a dose of 120 mg/ body/day for consecutive 14 days followed by 7 days of rest period with whole pelvis and bilateral inguinal radiation (total 45 Gy/25 Fr). Then we added a booster radiation (14 Gy/7 Fr) to a local area for 5 days followed by 2 days of rest period. After 2 weeks of chemo-radiotherapy, we could not detect any tumors by colonoscopy. We diagnosed it as a pathological complete response for biopsy specimen.
Dept. of Surgery, Toyonaka Municipal Hospital.
Taishi
T
Hata
Nobuyoshi
N
Ohara
Yasunori
Y
Masuike
Kohei
K
Okamoto
Tsuyoshi
T
Hata
Shiki
S
Fujino
Takehiro
T
Yanagawa
Tomohiro
T
Kitahara
Kazuteru
K
Oshima
Kenichi
K
Nagai
Takehiro
T
Noda
Masakazu
M
Miyake
Kenshu
K
Kawanishi
Shunji
S
Morita
Junya
J
Fujita
Takashi
T
Iwazawa
Kenzo
K
Akagi
Keizo
K
Dono
Masashi
M
Kitada
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid