The epigenetic code in depression: implications for treatment.
Major depressive disorder (MDD) is a common and disabling disorder that carries both a substantial personal burden as well as a social one. A better understanding of the epigenetic mechanisms in depression might provide a new framework for individually tailored pharmacologic treatment options. In this review we highlight current knowledge about the role of epigenetic mechanisms in the pathogenesis of depression and treatment implications.
Department of Psychiatry, Psychosomatic Medicine & Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany. marc.schroeder@kgu.de
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Schroeder
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Hillemacher
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Bleich
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Frieling
D000818:Animals; D019175:DNA Methylation / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D055808:Drug Discovery / Q000379:methods*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological
D056572:Histone Deacetylase Inhibitors