NSAIDs in the treatment and/or prevention of neurological disorders.
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used extensively in the treatment of inflammatory disorders and pain. In recent years, emerging data suggest that some NSAIDs possess pharmacological properties, in addition to cyclooxygenase inhibition, which may be beneficial in the treatment of several neurological conditions. For example, fenamate NSAIDs potentiate GABA-A receptor function, indomethacin scavenges nitric oxide free radicals, and acetylsalicylic acid inhibits the translocation of NF-κB, all of which may contribute to their neuroprotective actions in selected experimental models of stroke. The purpose of this review is to explore the diverse pharmacological properties of NSAIDs in relation to their potential value in the treatment of selected neurological diseases.
California Northstate College of Pharmacy, 10811 International Drive, Rancho Cordova, CA 95670, USA. pkhansari@calpharm.org
Parto S
PS
Khansari
Leanne
L
Coyne
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018696:Neuroprotective Agents