Serum leptin level and waist-to-hip ratio (WHR) predict the overall survival of metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs).
BACKGROUND
Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs).


METHODS
Sixty MBC patients treated with first line hormonal therapy were enrolled in this study.


RESULTS
Median age was 51 years (range 28-75). Median leptin level was 19400 pg/ml (1970-91900) and estradiol level 29.6 pg/ml (4.0-181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was ≥19400 pg/ml (HR = 0.38; 95% CI: 0.16-0.91).


CONCLUSIONS
This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.
Division of Medical Oncology, Selcuk University Meram Medical Faculty, Konya, Turkey. martac@selcuk.edu.tr
Mehmet
M
Artac
Hakan
H
Bozcuk
Aysel
A
Kiyici
Orhan Onder
OO
Eren
Melih Cem
MC
Boruban
Mustafa
M
Ozdogan
D000328:Adult; D000368:Aged; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D004958:Estradiol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012307:Risk Factors; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D015996:Survival Rate; D049629:Waist-Hip Ratio
D047072:Aromatase Inhibitors; D014408:Biomarkers, Tumor; D020738:Leptin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol