[Vitamin D and bisphosphonate-related osteonecrosis of the jaw (BRONJ) ].
Bisphosphonate have been widely used for the treatment of osteoporosis and malignant hypercalcemia or bone metastasis of solid cancers. Recently bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been reported. However the pathogenesis of BRONJ has been unclear. This article reviews the various hypotheses of the pathogenesis of BRONJ including our hypothesis for its pathogenesis.
Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry.
Akishige
A
Hokugo
D000818:Animals; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology* / Q000378:metabolism; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D016723:Bone Remodeling / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004164:Diphosphonates / Q000009:adverse effects*; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000187:drug effects; D018836:Inflammation Mediators / Q000378:metabolism; D009055:Mouth / Q000382:microbiology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D014808:Vitamin D Deficiency / Q000150:complications*
D050071:Bone Density Conservation Agents; D016207:Cytokines; D004164:Diphosphonates; D018836:Inflammation Mediators