Discrimination of healthy and glaucomatous eyes based on the ocular pulse amplitude: a diagnostic case-control study.
By measuring the ocular pulse amplitude (OPA), the dynamic contour tonometer (DCT) assesses intraocular pressure (IOP). Hypothesizing that OPA is characteristic for the IOP when considered with the systemic arterial blood pressure, we assumed the ratio of ocular and arterial pulsation amplitudes is larger in glaucoma patients. Bi-ocular DCT-OPA assessment was synchronized with arterial pulsations using Finapres® technology, thereby enabling blood pressure determination for each corresponding IOP value every 0.01 s for 12 s. Based on measurements and calculations in 10 healthy subjects and 11 glaucoma patients, we conclude that the ratio of the OPA and blood pressure variances is a strong glaucoma diagnostic indicator, thereby justifying further investigation.
Eye Department, Triemli Hospital, Zurich, Switzerland. robert-odc@swissonline.ch
Yves C A
YC
Robert
Andreas
A
Wild
Alfons G
AG
Kessels
Walter H
WH
Backes
Andreas
A
Zollinger
Lucas M
LM
Bachmann
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014065:Tonometry, Ocular