Hyaluronidase inhibitors from Keiskea japonica.
An extract of Keiskea japonica MIQ. showed an inhibitory effect on hyaluronidase activity. From the extract, four new phenylpropanoids, two new maltol glycosides, two new monoterpene glycosides, and two new phenolic compounds were isolated together with 19 known compounds. Among these constituents, two phenylpropanoids and a flavone glucuronide were revealed as hyaluronidase inhibitors.
Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp
Toshihiro
T
Murata
Toshio
T
Miyase
Fumihiko
F
Yoshizaki
D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D047309:Flavones; D006027:Glycosides; D039821:Monoterpenes; D010936:Plant Extracts; D006821:Hyaluronoglucosaminidase