[Effect of CD40 blockade on acute renal graft rejection in rats].
OBJECTIVE
To explore the effect of CD40 blockade in suppressing acute rejection of renal graft in rats.


METHODS
With Wistar rats as the donor and male SD rats as the recipients, rat models of acute renal graft rejection was established. The rat models were divided into therapy group and control group, and in the former group, CD40 ligand (CD40L) monoclonal antibody was injected daily for 4 consecutive days starting on the next day following kidney transplantation. On day 5 after the transplantation, the renal graft was harvested for histological examination, and graft rejection was evaluated semiquantitatively.


RESULTS
The mean semiquantitative score of the renal graft was 0.63∓0.52 in the therapy group, significantly lower than that of the control group (3.72∓1.48, P<0.05).


CONCLUSIONS
CD40L monoclonal antibody can inhibit acute renal graft in rats.
Department of Organ Transplantation, Southern Medical University, Guangzhou, China. sxh96@homail.com
Xiang-hua
XH
Shi
Xiao-you
XY
Liu
Xu-yong
XY
Sun
Ming
M
Zhao
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D019013:CD40 Antigens / Q000037:antagonists & inhibitors* / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy* / Q000517:prevention & control; D006085:Graft Survival / Q000187:drug effects; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D000911:Antibodies, Monoclonal; D019013:CD40 Antigens; D023201:CD40 Ligand