[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].
The level of specific 3H-flunitrazepam binding in synaptosomal membranes of C57BL/6 and BALB/c mice brain underwent to the stress of different types has been studied. Mild stress (Elevated Plus Maze) was shown to induce the decrease of benzodiazepine binding in BALB/c mice only, while the strong one (Exposure to a predator) was revealed to cause this decrease in both strains. Behavioral effects of different non-benzodiazepine drugs possessing anxiolytic properties (Afobazol, Ladasten and Noopept) was accompanied with the normalization of the level of benzodiazepine reception, reduced by the stress of both modalities.
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D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001562:Benzimidazoles / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D004151:Dipeptides / Q000494:pharmacology; D005445:Flunitrazepam / Q000032:analysis* / Q000378:metabolism; D058785:GABA-A Receptor Agonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009025:Morpholines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D013045:Species Specificity; D013312:Stress, Physiological / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D014316:Tritium / Q000032:analysis
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D004151:Dipeptides; D058785:GABA-A Receptor Agonists; D009025:Morpholines; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D011963:Receptors, GABA-A; D014316:Tritium; D001569:Benzodiazepines; C103871:ethyl phenylacetyl-Pro-Gly; D005445:Flunitrazepam; D000218:Adamantane