Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding.
The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?
Uppsala University, Uppsala, Sweden. lucy.mathot@igp.uu.se
Lucy
L
Mathot
Johan
J
Stenninger
D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D009360:Neoplastic Cells, Circulating; D059016:Tumor Microenvironment