Local reaction to the different meshes at the vesicovaginal space in rabbit model.
OBJECTIVE
This paper aims to study the vesicovaginal space local tissue reaction to type I and II polypropylene mesh in a rabbit model.


METHODS
Different types of meshes were implanted into the rabbit vesicovaginal space. The animals were killed at days 7 and 60, and the initial implant and the neighboring host tissue were removed, including the bladder and vaginal wall. Histopathology and immunohistochemistry (Ki-67 and proliferating cell nuclear antigen) were performed to evaluate the cell proliferation, and the indirect local inflammatory response was described.


RESULTS
One rabbit had erosion at the urinary bladder mucous membrane, which resulted in vesical stone formation in the type I mesh group at day 60. Obvious local tissue reaction was found after the different types of meshes were implanted, and the reaction tapered and disappeared over time. At day 7, the reaction in the type I mesh group was stronger than that in the type II group, while at day 60, the reaction shows no difference.


CONCLUSIONS
The two types of meshes could induce local tissue reaction, but this was stronger in type I mesh group at day 7 and shows no obvious difference between the two groups at day 60.
Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking, China.
Kun
K
Zhang
JinSong
J
Han
Ying
Y
Yao
Junfang
J
Yang
Jie
J
Qiao
D000818:Animals; D003877:Dermatitis, Contact / Q000453:epidemiology*; D005260:Female; D019394:Ki-67 Antigen / Q000378:metabolism; D008137:Longitudinal Studies; D023421:Models, Animal; D011126:Polypropylenes / Q000009:adverse effects* / Q000494:pharmacology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011817:Rabbits; D013526:Surgical Mesh / Q000009:adverse effects*; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D014621:Vagina / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*
D019394:Ki-67 Antigen; D011126:Polypropylenes; D018809:Proliferating Cell Nuclear Antigen