Antiplasmodial decarboxyportentol acetate and 3,4-dehydrotheaspirone from Laumoniera bruceadelpha.
A new spiro heterocycle, decarboxyportentol acetate (1) was isolated from the barks of Laumoniera bruceadelpha Nooteboom (Simaroubaceae), together with 3,4-dehydrotheaspirone (2), and their structures were elucidated by 2D NMR analysis. 3,4-Dehydrotheaspirone (2) showed potent antiplasmodial activity against Plasmodium falciparum 3D7.
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
Hiroshi
H
Morita
Reika
R
Mori
Jun
J
Deguchi
Shiori
S
Oshimi
Yusuke
Y
Hirasawa
Wiwied
W
Ekasari
Aty
A
Widyawaruyanti
A Hamid A
AH
Hadi
D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D029641:Simaroubaceae / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology*
C560463:3,4-dehydrotheaspirone; D000962:Antimalarials; D013141:Spiro Compounds