Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children.
BACKGROUND
The aim of this study was to evaluate whether slow injection of diluted rocuronium could reduce rocuronium-induced withdrawal movements effectively in children.


METHODS
After loss of consciousness, rocuronium 0.6 mg/kg was administered into 171 children according to the pre-assigned groups as follows: Group CF, injection of non-diluted rocuronium over 5 seconds; Group CS, injection of non-diluted rocuronium over 1 minute; Group DF, injection of diluted rocuronium (10 times) over 5 seconds; Group DS, injection of diluted rocuronium over 1 minute. An investigator who was blind to the injection techniques recorded patient movements followed by rocuronium injection.


RESULTS
The incidence of withdrawal movement in Group CF was highest among the groups (all P < 0.0001). Moreover, withdrawal movement was less frequently observed in Group DS than in Groups CS and DF (P = 0.021 and P = 0.007, respectively).


CONCLUSIONS
Slow injection of diluted rocuronium reduced the incidence of withdrawal movements in children.
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Young Hee
YH
Shin
Chung Su
CS
Kim
Jong-Hwan
JH
Lee
Woo Seog
WS
Sim
Justin Sangwook
JS
Ko
Hyun Sung
HS
Cho
Hui Yeon
HY
Jeong
Hye Won
HW
Lee
Sang Hyun
SH
Kim