miRNAs in breast cancer tumorigenesis (Review).
miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding             mRNAs at the post-transcriptional level. It is estimated that in humans thousands             of miRNAs are expressed and more than 700 miRNAs have been described to date.             About 50% of annotated human miRNAs are detected in regions of fragile sites,             which are associated with cancer. The available evidence has shown that miRNAs             widely participate in the development or progression of many types of cancers,             including breast cancer. The role of miRNAs in breast cancer has been widely investigated;             here, we will focus on what is known about the working mechanism of miRNAs in             different stages of breast cancer development.
College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang 110866, PR China.
Zhong Ju
ZJ
Zhang
Shi Liang
SL
Ma
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015398:Signal Transduction / Q000235:genetics
D035683:MicroRNAs