Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity.
The authors describe the neuropsychiatric spectrum of voltage-gated potassium-channel complex (VGKC) autoimmunity among 67 seropositive patients; 2 had initially been assigned a primary psychiatric diagnosis. Diverse manifestations were recorded, often affective-predominant. Symptoms for 24 patients with florid presentations included confusion, 92%; memory impairment, 75%; personality change, 58%; depression, 33%; and anxiety, 29%. Of 15 who received immunotherapy, 67% improved. Forty-three patients with milder presentations or low positive VGKC complex Ab values are also described. Neuropsychiatric presentations were significantly associated with higher autoantibody values. Improvements were most evident in patients treated early, which emphasizes the need for early diagnosis and immunotherapy initiation.
Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Kristin J
KJ
Somers
Vanda A
VA
Lennon
James R
JR
Rundell
Sean J
SJ
Pittock
Daniel A
DA
Drubach
Max R
MR
Trenerry
Daniel H
DH
Lachance
Christopher J
CJ
Klein
Paula A
PA
Aston
Andrew
A
McKeon
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity / Q000276:immunology*; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000097:blood* / Q000276:immunology*; D008875:Middle Aged; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated