CHD chromatin remodelers and the transcription cycle.
It is well established that ATP-dependent chromatin remodelers modulate DNA access of transcription factors and RNA polymerases by "opening" or "closing" chromatin structure. However, this view is far too simplistic. Recent findings have demonstrated that these enzymes not only set the stage for the transcription machinery to act but are actively involved at every step of the transcription process. As a consequence, they affect initiation, elongation, termination and RNA processing. In this review we will use the CHD family as a paradigm to illustrate the progress that has been made in revealing these new concepts.
Institute of Molecular Biology and Tumor Research, Philipps University Marburg, Marburg, Germany.
Magdalena
M
Murawska
Alexander
A
Brehm
D000255:Adenosine Triphosphate / Q000378:metabolism; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D008957:Models, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D002843:Chromatin; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA