Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals.
It has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy homeostasis, insulin secretion, and sensitivity, suggesting that ATF4 is a master regulator of metabolism. This review summarizes the most recent progress in the understanding of the novel roles of ATF4 in the regulation of metabolism.
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, The Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China.
Chunxia
C
Wang
Feifan
F
Guo
D051701:Activating Transcription Factor 4 / Q000378:metabolism*; D000818:Animals; D050260:Carbohydrate Metabolism; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism
D051701:Activating Transcription Factor 4