Treatment of Paget's disease of bone.
Paget's disease of bone is the paradigm of bone focal distortion with accelerated bone turnover. Over the years, a number of different drugs have been used to control its activity but, since biphosphonates were introduced for the treatment of the disease, they have become the preferred treatment. This review will update the therapeutic indications, available drugs and therapeutic response monitoring.
Unidad Metabólica Ósea, Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain. leticialojooliveira2@yahoo.es
Leticia
L
Lojo Oliveira
Antonio
A
Torrijos Eslava
D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers; D002118:Calcium / Q000627:therapeutic use; D024042:Collagen Type I / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use; D019468:Disease Management; D017558:Elective Surgical Procedures; D005598:Fractures, Spontaneous / Q000517:prevention & control; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D009408:Nerve Compression Syndromes / Q000209:etiology / Q000517:prevention & control; D010001:Osteitis Deformans / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D012008:Recurrence; D014807:Vitamin D / Q000627:therapeutic use
D015415:Biomarkers; D024042:Collagen Type I; D004164:Diphosphonates; D014807:Vitamin D; D000469:Alkaline Phosphatase; D002118:Calcium