Size matters: smart copolymeric nanohydrogels: synthesis and applications.
In this work the synthesis of smart nanoparticles capable of respond to external stimulus (pH and temperature variations) is reported. To avoid post-polymerization modification, functionalized monomers able to respond to pH and temperature changes were and then polymerized. The synthesized monomers have the capability for coupling with folic acid which is the target molecule. For this reason their polymers can be used as targeted drug delivery systems. Smart polymeric nanoparticles were prepared by direct and inverse microemulsion polymerization of the synthesized monomers. The nanoparticles were charged with drugs and their release kinetic was studied.
Grupo de Nuevos Materiales y Espectroscopia Supramolecular, Facultad de Ciencia y Tecnologia, Campus de Leioa, Spain. issa.katime@ehu.es
Issa
I
Katime
Luis Guillermo
LG
Guerrero
Eduardo
E
Mendizabal
D020100:Hydrogels; D049329:Nanostructures; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D020100:Hydrogels; D011108:Polymers