Influence of lifestyle habits, nutritional status and insulin resistance in NAFLD.
Non alcoholic fatty liver disease (NAFLD) is associated with obesity, diabetes and insulin resistance (IR). The aim of our study was to assess the relationship between IR, anthropometry, lifestyle habits, resting energy expenditure (REE) and degree of fatty liver at ultrasound in 48 overweight patients with NAFLD as compared to 24 controls without fatty liver, matched for age. Nutritional status, alcohol intake and physical activity were assessed by skinfold thickness measurements, a 7-day diary, and SenseWear armband (SWA). REE was assessed by both SWA (REE-SWA) and a Vmax metabolic cart (REE-Vmax). Fatty liver was measured by US and the Doppler Power Index was calculated. IR was assessed using the HOMA index. There was significant correlation between waist circumference, HOMA, Doppler power index and fatty liver grade at US. Multivariate analysis showed that alteration of waist circumference, Doppler power index, and HOMA were the major significant predictors of fatty liver. Our data demonstrated a significant association between NAFLD and central adiposity and IR.
Department of Public Health, Medical School University of Modena and Reggio Emilia, Modena, Italy. marcella.malavolti@unimore.it
Marcella
M
Malavolti
Nino Carlo
NC
Battistini
Lucia
L
Miglioli
Ilaria
I
Bagni
Luca
L
Borelli
Mariano
M
Marino
Federica
F
Scaglioni
Stefano
S
Bellentani
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004734:Energy Metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease; D009752:Nutritional Status