Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium in cattle in England and Wales.
Salmonella is the second most commonly reported human foodborne pathogen in England and Wales, and antimicrobial-resistant strains of Salmonella are an increasing problem in both human and veterinary medicine. In this work we used a generalized linear spatial model to estimate the spatial and temporal patterns of antimicrobial resistance in Salmonella typhimurium in England and Wales. Of the antimicrobials considered we found a common peak in the probability that an S. typhimurium incident will show resistance to a given antimicrobial in late spring and in mid to late autumn; however, for one of the antimicrobials (streptomycin) there was a sharp drop, over the last 18 months of the period of investigation, in the probability of resistance. We also found a higher probability of resistance in North Wales which is consistent across the antimicrobials considered. This information contributes to our understanding of the epidemiology of antimicrobial resistance in Salmonella.
National Centre for Zoonosis Research, Leahurst, University of Liverpool, Wirral, UK. rucox@upei.ca
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Cox
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Clough
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Woodward
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Sherlock
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001499:Bayes Theorem; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000382:microbiology*; D002701:Chloramphenicol / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004739:England / Q000453:epidemiology; D015994:Incidence; D016014:Linear Models; D008390:Markov Chains; D009010:Monte Carlo Method; D011159:Population Surveillance; D012481:Salmonella Infections, Animal / Q000453:epidemiology / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000302:isolation & purification; D012621:Seasons; D062211:Spatio-Temporal Analysis; D013307:Streptomycin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D014852:Wales / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D002701:Chloramphenicol; D013307:Streptomycin