Synthesis of biologically stable gold nanoparticles using imidazolium-based amino acid ionic liquids.
A novel double-step reduction procedure for the synthesis of gold nanoparticles (AuNPs) using amino acid ionic liquids has been employed. 1-Dodecyl-3-methyl imidazolium tryptophan ([C(12)mim]Trp) and 1-ethyl-3-methyl imidazolium tryptophan ([C(2)mim]Trp) were used for this synthesis. The synthesized AuNPs were characterized by UV-vis spectroscopy, transmission electron microscopy and dynamic light scattering. The behavior of these AuNPs were also probed in a biological media. It was proven that AuNPs synthesized at [C(12)mim]Trp have more stability than AuNPs synthesized at [C(2)mim]Trp due to the longer alkyl chain of the imidazolium moiety. The solubility test shows that the resultant AuNPs have a hydrophilic nature. Finally, it was seen that due to the presence of a biomolecule, namely Trp, in the structure of AuNPs protecting shell, higher stability and biocompatibility was achieved in the biological media.
Department of Chemistry, College of Science, Shiraz University, Shiraz, Fars, Iran. safavi@chem.susc.ac.ir
Afsaneh
A
Safavi
Sedigheh
S
Zeinali
Mahdieh
M
Yazdani
D001894:Borohydrides / Q000737:chemistry; D003470:Culture Media / Q000737:chemistry; D004355:Drug Stability; D006046:Gold / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D052578:Ionic Liquids / Q000138:chemical synthesis / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010316:Particle Size; D019163:Reducing Agents / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D020349:Surface Plasmon Resonance; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*
D001894:Borohydrides; D003470:Culture Media; D007093:Imidazoles; D052578:Ionic Liquids; D019163:Reducing Agents; D006046:Gold; C025364:sodium borohydride; D014364:Tryptophan