Status of oxidative stress on lesional skin surface of plantar warts.
BACKGROUND
Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of the patients. Sometimes the disease is difficult to treatment, and also, the relationship between HPV and some forms of skin cancers is important. The cutaneous oxidative stress status of warts is absent in the literature.


OBJECTIVE
To evaluate the role of oxidative stress in affected skin areas in a group of patients with plantar warts.


METHODS
Thirty-six consecutive patients with a diagnosis of plantar warts were enrolled. The samples were obtained by scraping the skin surface. Superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) levels were measured spectrophotometrically at samples.


RESULTS
The SOD activity was significantly lower, and the MDA level was significantly higher on the lesional area than on the non-lesional area (P < 0.001 for each), and there was no significant difference in the CAT activity between both areas (P = 0.11).


CONCLUSIONS
Cutaneous oxidative stress in patients with plantar warts may play a role in pathogenesis of the disease. The addition of topical drugs with antioxidative effects may be valuable in the treatment of warts.
Department of Dermatology, Medical Faculty, Trakya University, Edirne, TurkeyDepartments of Dermatology Biochemistry, Medical Faculty, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey.
O
O
Arican
P
P
Ozturk
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EB
Kurutas
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V
Unsal
D000293:Adolescent; D000328:Adult; D002374:Catalase / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014860:Warts / Q000201:enzymology / Q000378:metabolism*; D055815:Young Adult
D002374:Catalase; D013482:Superoxide Dismutase