Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy.
OBJECTIVE
Although serum tenascin-C (TN-C) levels are related to left ventricular (LV) remodeling in patients with myocardial infarction and are useful as a prognostic biomarker of heart failure in patients with dilated cardiomyopathy, the clinical significance of TN-C levels has not yet been studied in patients with hypertrophic cardiomyopathy (HCM). Therefore, the purpose of this study is to elucidate whether serum TN-C levels are a prognostic biomarker for heart failure in patients with HCM.


METHODS
The relationship between serum TN-C levels and heart failure events was studied in 36 patients with HCM during follow-up.


RESULTS
Levels of serum TN-C were 28±13 ng/ml (range 11-80 ng/ml). Although patients with LV systolic impairment showed higher TN-C levels than those with preserved LV systolic function (33±11 ng/ml vs. 27±14 ng/ml; p=0.16), TN-C levels were not related to any echocardiographic parameters. During the follow-up period of 4.8±1.4 years, heart failure events were observed in six patients and TN-C levels in patients with events were higher than those in patients without events. Kaplan-Meier analysis showed that the prognosis was worse in patients with high TN-C levels (≥39.2 ng/ml) than in those with low TN-C levels.


CONCLUSIONS
Heart failure events were more frequently observed in patients with high serum TN-C levels than in those with low TN-C levels. Serum TN-C levels may be a new prognostic biomarker for heart failure in patients with HCM.
Cardiology Division, Department of Medicine and Geriatrics, Kochi Medical School, Oko-cho, Kochi 783-8505, Japan. kitaokah@kochi-u.ac.jp
Hiroaki
H
Kitaoka
Toru
T
Kubo
Yuichi
Y
Baba
Naohito
N
Yamasaki
Yoshihisa
Y
Matsumura
Takashi
T
Furuno
Yoshinori L
YL
Doi
D015415:Biomarkers / Q000097:blood*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019063:Tenascin / Q000097:blood*
D015415:Biomarkers; D019063:Tenascin