Blood natural killer cell cytotoxicity enhancement correlates with an increased activity in brain motor structures following chronic stimulation of the bed nucleus of the stria terminalis in rats.
The present study indicates that a chronic 14 day electrical stimulation of the bed nucleus of the stria terminalis (BST) increased blood but not spleen natural killer cell (NK) cytotoxicity and a large granular lymphocyte (LGL) number. These immune changes positively correlated with the increased activity in brain cortical and subcortical motor structures that influence the BST stimulation-induced behavioral response. No significant changes in blood and spleen leukocyte population numbers and plasma corticosterone concentration after the stimulation were found. The obtained results suggest that this immunoenhancing effect on blood NK cell function and number is dependent on the behavioral outcome of the BST stimulation rather than endocrine response.
Department of Animal Physiology, University of Gdańsk, 24 Kładki St., 80-822 Gdańsk, Poland.
Dorota
D
Myślińska
Karolina
K
Plucińska
Wojciech
W
Glac
Danuta
D
Wrona
D000704:Analysis of Variance; D000818:Animals; D002452:Cell Count; D003345:Corticosterone / Q000097:blood; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000502:physiology*; D004558:Electric Stimulation; D007694:Killer Cells, Natural / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D018655:Lymphocyte Count / Q000379:methods; D008297:Male; D009043:Motor Activity / Q000276:immunology*; D009434:Neural Pathways / Q000502:physiology; D016761:Oncogene Proteins v-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012686:Septal Nuclei / Q000502:physiology*; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D013997:Time Factors; D015854:Up-Regulation / Q000276:immunology
D016761:Oncogene Proteins v-fos; D003345:Corticosterone