[Cardiovascular biomarkers in clinical practice of sleep apnea].
Obstructive sleep apnea syndrome (OSAS) leads to cardiovascular complications such as coronary artery disease, left/right ventricular hypertrophy and dysfunction, heart failure, systemic and pulmonary hypertension, arrhythmias and stroke; and these all cardiovascular complications increase morbidity and mortality of OSAS. However, Cheyne-Stokes respiration, central and obstructive apneas may occur in the patient with heart failure. Increased sympathetic activity by hypoxemia and endothelial dysfunction play a role in cardiovascular complications. Some cardiovascular biomarkers have a role in early diagnosis, treatment and prognosis. In the present review, some cardiovascular biomarkers such as serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukins, adiponectin, heart-type fatty acid binding protein (hFABP) and brain (B-type) natriuretic peptide (BNP), and their clinical importance were reviewed.
Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. dursundursunoglu@yahoo.com
Dursun
D
Dursunoğlu
Neşe
N
Dursunoğlu
D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D042241:Early Diagnosis; D006801:Humans; D007378:Interleukins / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein