The neuroanatomy of visual enumeration: differentiating necessary neural correlates for subitizing versus counting in a neuropsychological voxel-based morphometry study.
This study is the first to assess lesion-symptom relations for subitizing and counting impairments in a large sample of neuropsychological patients (41 patients) using an observer-independent voxel-based approach. We tested for differential effects of enumerating small versus large numbers of items while controlling for hemianopia and visual attention deficits. Overall impairments in the enumeration of any numbers (small or large) were associated with an extended network, including bilateral occipital and fronto-parietal regions. Within this network, severe impairments in accuracy when enumerating small sets of items (in the subitizing range) were associated with damage to the left posterior occipital cortex, bilateral lateral occipital and right superior frontal cortices. Lesions to the right calcarine extending to the precuneus led to patients serially counting even small numbers of items (indicated by a steep response slope), again demonstrating an impaired subitizing ability. In contrast, impairments in counting large numerosities were associated with damage to the left intraparietal sulcus. The data support the argument for some distinctive processes and neural areas necessary to support subitization and counting with subitizing relying on processes of posterior occipital cortex and with counting associated with processing in the parietal cortex.
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, United Kingdom. nele.demeyere@psy.ox.ac.uk
Nele
N
Demeyere
Pia
P
Rotshtein
Glyn W
GW
Humphreys
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000150:complications; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D011340:Problem Solving / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013223:Statistics as Topic; D014795:Visual Pathways / Q000473:pathology