Enantioselective catalysis at the DNA scaffold.
The unique chiral structure and the highly specific Watson-Crick base-pairing interactions that characterize natural double-stranded DNA, make this natural biopolymer an attractive ligand for asymmetric catalytic processes. In this chapter the applications of DNA as scaffold and chiral ligand in enantioselective transition metal catalysis are presented. An overview of the state of the art for the different approaches to metal-DNA based catalysts is given, followed by an overview of the mechanistic studies that have been performed to date.
Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Almudena
A
García-Fernández
Gerard
G
Roelfes
D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism
D008670:Metals; D004247:DNA