Chronic pharyngitis is associated with severe acidic laryngopharyngeal reflux in patients with Reinke's edema.
OBJECTIVE
We evaluated the association between pathological acidic laryngopharyngeal reflux (LPR) events and chronic pharyngitis in patients with Reinke's edema.


METHODS
We performed a prospective controlled study in 20 consecutive patients with Reinke's edema without pathological acidic LPR events (group A) and 40 consecutive patients with Reinke's edema with both clinical symptoms and 24-hour pH-metry suggesting acidic LPR (group B). The severity of acidic LPR was assessed by use of the Reflux Finding Score (RFS), the Reflux Symptom Index (RSI), and dual antimony probe 24-hour pH-metry. The patients were evaluated for the presence of chronic pharyngitis by clinical examination and biopsy specimens taken from the posterior pharyngeal wall. The Chi2 test was used to compare the groups for the presence of pharyngitis. In group B, the RSI, the RFS, and the total duration and number of acidic LPR events on 24-hour pH-metry were compared between patients with and without concomitant pharyngitis by use of the Mann-Whitney test.


RESULTS
Five patients of group A and 20 patients of group B had chronic pharyngitis. Therefore, more patients with Reinke's edema and clinical signs of LPR tended to have chronic pharyngitis than did those with Reinke's edema and no clinical signs of LPR, but the difference was not statistically significant (p = 0.064; odds ratio, 3.0; 95% confidence interval, 0.9 to 9.8). Among group B patients, those with pharyngitis had significantly more acidic LPR events (p < 0.001) and a greater exposure time to gastric fluid (p = 0.008) than did those without pharyngitis. Their RFS and RSI did not differ significantly (p = 0.692 and p = 0.914, respectively).


CONCLUSIONS
Only in the subgroup of patients with Reinke's edema and LPR was there a statistically significant correlation between the pH probe results and the incidence of clinical pharyngitis. Awareness should increase among physicians about addressing chronic pharyngitis in therapy for acidic LPR and/or Reinke's edema.
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Nikolaos
N
Kamargiannis
Haralampos
H
Gouveris
Panagiotis
P
Katsinelos
Michael
M
Katotomichelakis
Maria
M
Riga
Athanasios
A
Beltsis
Vasilios
V
Danielides
D000328:Adult; D000368:Aged; D000465:Algorithms; D001706:Biopsy; D016022:Case-Control Studies; D002908:Chronic Disease; D050782:Esophageal pH Monitoring; D005260:Female; D006801:Humans; D007819:Laryngeal Edema / Q000150:complications* / Q000175:diagnosis; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000209:etiology*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010612:Pharyngitis / Q000150:complications* / Q000175:diagnosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric