[Propofol versus midazolam and pethidine in the colonoscopy realization].
BACKGROUND
Medications to relief pain are more common in the everyday use during the colonoscopy practice, although schemes of medications vary.


OBJECTIVE
To evaluate the efficacy and the safety of propofol versus midazolam and petidhine in colonoscopy.


METHODS
A randomized and simple-blind controlled clinical trial was carried out. We included 512 patients who underwent a colonoscopy during the period from February 2008 to January 2009. using propofol in one group and midazolam plus petidhine in another.


RESULTS
Cecal intubation was achieved in 247 patients (96.5%) with propofol and in 256 patients (100%) with midazolam plus petidhine. There were no significant differences between both methods regarding to the explored colon distance. Fifty-five patients (21.5%) had complications in the group receiving midazolam plus petidhine and 3 (1.2%) in the group receiving propofol. Complications were mild in both groups. Propofol reduced the relative risk of complications in 94.6% and absolute risk in 20.3%. Patients referred the same satisfaction degree with both methods.


CONCLUSIONS
The use of propofol and midazolam plus petidhine is equally efficacious in the performance of the colonoscopy, while propofol is safer than midazolam plus propofol as a method of deep sedation.
Hospital Clínico Quirúrgico Docente Joaquín Albarrán, La Habana, Cuba. carbajal@infomed.sld.cu
Miguel González-Carbajal
MG
Pascual
Mónica
M
Zayas Berbes
Milagros
M
Sáez Baños
María del Rosario
Mdel R
Abreu Vázquez
Ludmila
L
Martínez Leyva
D000759:Adjuvants, Anesthesia; D000328:Adult; D000368:Aged; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008614:Meperidine; D008874:Midazolam; D008875:Middle Aged; D017060:Patient Satisfaction; D015742:Propofol; D018570:Risk Assessment; D016037:Single-Blind Method; D055815:Young Adult
D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D008614:Meperidine; D008874:Midazolam; D015742:Propofol