Histopathological and immunohistochemical aspects in chronic suppurative maxillary rhinosinusitis.
Chronic rhinosinusitis is a multifactorial disease with pathophysiological mechanisms, which remain unclear, and with a high prevalence worldwide. They generate social problems due to the high number of days of leave and relatively elevated medical expenses. The histopathological and immunohistochemical study that we conducted revealed many lesional aspects of the epithelium of the sinus mucosa, which ranged from hypertrophy, hyperplasia and metaplasia, to erosion and discontinuities. In the chorion of the sinus mucosa there was an inflammatory infiltrate composed mainly of lymphocytes, plasma cells and macrophages, and also a highly developed vascular network. Among immune cells, T-cells appeared to be more numerous than B-lymphocytes and macrophages. We believe that microscopic changes are due mainly to microscopic organisms that make up the biofilm of the sinus cavity, whose virulence has been more or less influenced by exogenous or endogenous factors.
Department of ENT, University of Medicine and Pharmacy of Craiova, Romania.
G
G
Stanciu
Carmen Aurelia
CA
Mogoantă
Elena
E
Ioniţă
Olivia Carmen
OC
Timnea
Garofiţa Olivia
GO
Mateescu
Nina
N
Ionovici
O T
OT
Pop
Irina
I
Gheorghişor
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008443:Maxillary Sinus / Q000473:pathology*; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009666:Nose / Q000473:pathology*; D012852:Sinusitis / Q000150:complications* / Q000473:pathology*; D013492:Suppuration / Q000150:complications* / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology