CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.
Predicting the clinical course of osteosarcoma patients is a crucial prerequisite for a better treatment stratification in these highly aggressive neoplasms of bone. In search of new and reliable biomarkers we recently identified cysteine-rich intestinal protein 1 (CRIP1) to have significant prognostic impact in gastric cancer and therefore decided to investigate its role also in osteosarcoma. For this purpose we analyzed 223 pretherapeutic and well characterized osteosarcoma samples for their immunohistochemical expression of CRIP1 and correlated our findings with clinico-pathological parameters including follow‑up, systemic spread and response to chemotherapy. Interestingly and contrarily to gastric cancer, we found CRIP1 expression more frequently in patients with long‑term survival (10-year survival 73% in positive vs. 54% in negative cases, p = 0.0433) and without metastases (p = 0.0108) indicating a favorable prognostic effect. CRIP1 therefore seems to represent a promising new biomarker in osteosarcoma patients which should be considered for a prospective validation.
Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland. dbaumhoer@mac.com
Daniel
D
Baumhoer
Mareike
M
Elsner
Jan
J
Smida
Stephanie
S
Zillmer
Sandra
S
Rauser
Cédrik
C
Schoene
Benjamin
B
Balluff
Stefan
S
Bielack
Gernot
G
Jundt
Axel
A
Walch
Michaela
M
Nathrath
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D060588:LIM Domain Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
D014408:Biomarkers, Tumor; C486181:CRIP1 protein, human; D002352:Carrier Proteins; D060588:LIM Domain Proteins