Minimizing strain influences in a genetically modified mouse phenotyping platform.
Our approach has been to power studies to allow for detection of at least modest changes from a wild-type littermate control, include assays with overlapping physiological systems to provide cross-functional interpretive value, and to employ challenge assays.
Taconic, Discovery & Preclinical Research Solutions, Cranbury, New Jersey, USA. Michael.Hayward@Taconic.com
Michael D
MD
Hayward
Olesia
O
Buiakova
David S
DS
Grass
D000818:Animals; D001947:Breeding; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000502:physiology; D008822:Mice, Transgenic / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D013045:Species Specificity