Effectiveness of Ischia thermal water nasal aerosol in children with seasonal allergic rhinitis: a randomized and controlled study.
Allergic rhinitis is characterized by local inflammation. Nasal lavage may be a useful treatment, however, there are few studies on this topic. This study aims to evaluate the effects of Ischia thermal water nasal irrigation on allergic rhinitis symptoms and airway inflammation during the period of natural exposure to Parietaria pollen in children with allergic rhinitis and intermittent asthma. Forty allergic children were randomly divided into two groups: the first group (Group 1) practiced crenotherapy with thermal water aerosol for 15 days per month, for three consecutive months, the control group (Group 2) was treated with 0.9&#x0025; NaCl (isotonic) solution. In addition, all children were treated with cetirizine (0.5 gtt./kg/day once daily). Nasal symptom assessment, including Total Symptom Score (TSS), spirometry, and exhaled nitric oxide (FeNO) were considered before the treatment (T0), at the end of the treatment (T1) and again 2 weeks after the end of the treatment (T2). The study was registered in the Clinical Trials.gov (NCT01326247). Thermal water significantly reduced both TSS and FeNO levels and there was a significant relationship between reduction of nasal symptoms and FeNO values at the end of treatment with thermal water. In conclusion, this study shows that nasal crenotherapy with the hypermineral chloride-sodium water of Ischia was effective in children with seasonal allergic rhinitis based on the sensitivity to Parietaria. These results demonstrate that this natural treatment may be effective in a common and debilitating disease such as the allergic rhinitis.
M
M
Miraglia Del Giudice
F
F
Decimo
N
N
Maiello
S
S
Leonardi
G
G
Parisi
M
M
Golluccio
M
M
Capasso
U
U
Balestrieri
A
A
Rocco
L
L
Perrone
G
G
Ciprandi
D000293:Adolescent; D000704:Analysis of Variance; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D001944:Breath Tests; D017332:Cetirizine / Q000627:therapeutic use; D002648:Child; D005260:Female; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use; D006801:Humans; D007558:Italy; D008297:Male; D008900:Mineral Waters / Q000008:administration & dosage*; D059085:Nasal Sprays; D032403:Parietaria / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D013147:Spirometry; D007507:Therapeutic Irrigation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
D018926:Anti-Allergic Agents; D039563:Histamine H1 Antagonists, Non-Sedating; D008900:Mineral Waters; D059085:Nasal Sprays; D017332:Cetirizine