Influence of phosvitin and calcium gluconate concentration on permeation and intestinal absorption of calcium ions.
The effect of egg yolk phosvitin on the permeation and absorption of calcium was investigated in vitro in relation to calcium gluconate concentration. Obtained results indicate that phosvitin significantly reduces the intestinal calcium absorption from 1 and 10 mM of calcium gluconate solution. It is associated with the formation of the complex of Ca (II) ions with phosvitin. The process of calcium permeation increases under phosvitin influence when calcium gluconate concentrations rise up to 10 mM. At a higher concentration of calcium gluconate (20 mM), no effect of phosvitin was seen on permeation of calcium ions.
Biochefa Pharmaceutical Research and Production Plant, Sosnowiec, Poland. b.dolinska@biochefa.pl
Barbara
B
Dolińska
Katarzyna
K
Łopata
Agnieszka
A
Mikulska
Lucyna
L
Leszczyńska
Florian
F
Ryszka
D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics*; D002125:Calcium Gluconate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007477:Ions / Q000493:pharmacokinetics; D010539:Permeability / Q000187:drug effects; D010774:Phosvitin / Q000494:pharmacology*; D013552:Swine
D007477:Ions; D010774:Phosvitin; D002125:Calcium Gluconate; D002118:Calcium