Mitotic checkpoint control and chromatin remodeling.
In order to maintain chromosomal stability during cell division, eukaryotic cells have evolved a number of surveillance mechanisms termed checkpoints. These checkpoints monitor the completion of essential molecular and cellular processes of one stage before entering another. The spindle checkpoint watches the bi-orientation attachment of spindle microtubules to all condensed chromosomes before initiation of nuclear division during mitosis. Histones are subject to a number of post-translational modifications during the cell cycle, which may in turn modify or facilitate cell cycle progression. Recent studies suggest that mitotic proteins including Bub1 and Sgo1 that are involved in the spindle checkpoint also play a major role in the regulation of histone modifications and chromatin remodeling. This mini-review summarizes emerging information about the new role of spindle checkpoint proteins in chromatin remodeling.
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.
Yixin
Y
Yao
Wei
W
Dai
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D042002:Chromatin Assembly and Disassembly / Q000235:genetics / Q000502:physiology*; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D020033:Protein Isoforms / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology
D018797:Cell Cycle Proteins; D020033:Protein Isoforms; C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases