Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines.
Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.
Department of Pediatrics, Mofid Children Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Shahrzad
S
Fallah
Ahmad
A
Tabatabaei
Zahra
Z
Pournasir
Zahra
Z
Chavoshzadeh
Nima
N
Rezaei
D002648:Child; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology; D004279:DNA, Viral / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D016133:Polymerase Chain Reaction; D017193:Skin Diseases, Viral / Q000175:diagnosis* / Q000276:immunology
D004279:DNA, Viral; D007073:Immunoglobulin E