Corticomedullary mixed tumor of the adrenal gland-a clinical and pathological chameleon: case report and review of literature.
Adrenal tumors mostly present with specific and unique clinical features, regarding their endocrine metabolism. A 53-year-old man came to our Department for a left adrenal mass discovered incidentally. Biochemical and imaging findings were suspicious for a pheochromocytoma. The patient underwent a laparoscopic left adrenalectomy. A well-circumscribed 5.5-cm mass was removed. It was composed of adrenal cells intimately admixed with pheochromocytes. Immunohistochemical studies were positive both for cortical cells (inibin-α, synaptophysine and melan-A) and medullary cells (S-100 and chromogranine A). Final pathology was of corticomedullary mixed tumor (CMT). CMT is a rare tumor with 14 cases previously reported in literature, with wide variable biochemical behavior, such as his radiological and pathological features. Prevalence and actual malignant potential are yet unknown to our knowledge.
Department of General and Endocrine Surgery, CHR Huriez, Lille Cedex, France. giacko76@hotmail.com
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Donatini
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Van Slycke
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S
Aubert
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Carnaille
D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000473:pathology*