Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles.
BACKGROUND
High levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH).


RESULTS
Average Lp(a) concentration was reduced by 70%, 74% and 75% (all p<0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32K 4 domains were observed after apheresis.


CONCLUSIONS
Three different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms.
Coronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway. anders.w.hovland@gmail.com
Anders
A
Hovland
Santica
S
Marcovina
Randolf
R
Hardersen
Terje
T
Enebakk
Tom Eirik
TE
Mollnes
Knut Tore
KT
Lappegård
D001054:Apolipoproteins A; D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods; D002318:Cardiovascular Diseases / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D008052:Lipid Metabolism, Inborn Errors / Q000097:blood / Q000628:therapy*; D017270:Lipoprotein(a); D008297:Male
D001054:Apolipoproteins A; D017270:Lipoprotein(a)