Relationship between diagnosis and intervention in women with inherited bleeding disorders and menorrhagia.
Menorrhagia is the most common bleeding manifestation in women with inherited bleeding disorders. There is little known about whether the management of menorrhagia is altered in specific bleeding disorders. Optimizing treatment strategies for each specific diagnosis may improve quality of life in these women. This work aimed to look for a potential relationship between the specific diagnosis of an inherited bleeding disorder and the intervention required to control the menorrhagia. A retrospective chart review was performed for all women seen in the Kingston Women and Bleeding Disorders Clinic. Patients were categorized by diagnosis into two groups: Haemophilia carriers and all others. Treatment options were grouped into two categories: Medical or gynecological/surgical. Overall, 85.7% of haemophilia carriers required gynaecological surgical management, whereas only 31.4% of patients with all other diagnoses required gynaecological/surgical management (P = 0.012, Fisher's exact test). Therefore, carriers of Haemophilia were more likely to have a better outcome in treating their menorrhagia with gynaecological or surgical management compared with medical management. This information may 1 day help to guide treatment choice for menorrhagia in women with bleeding disorders.
Department of Medicine, Queens University, Kingston, ON, Canada.
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S
Sanders
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Purcell
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M
Silva
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Palerme
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P
James
D000328:Adult; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis; D002836:Hemophilia B / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008595:Menorrhagia / Q000209:etiology*; D012189:Retrospective Studies; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis