Conjugated polymers for light-activated antifungal activity.
A cationic polythiophene-porphyrin (PTP) dyad is shown to exhibit efficient light-activated antifungal activity. Higher singlet oxygen (¹O₂) generation efficiency can be attained from PTP upon photoexcitation due to the light-harvesting properties of the polymer backbone and efficient energy transfer from the polythiophene to the porphyrin units. PTP can be used for treating fungal infections in lower doses of irradiation light and polymer concentration.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China.
Chengfen
C
Xing
Gaomai
G
Yang
Libing
L
Liu
Qiong
Q
Yang
Fengting
F
Lv
Shu
S
Wang
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D004735:Energy Transfer / Q000187:drug effects; D008027:Light; D008826:Microbial Sensitivity Tests; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D011108:Polymers; D011166:Porphyrins; D013876:Thiophenes; C066730:polythiophene