Molecular pharmacology of the mouse melatonin receptors MT₁ and MT₂.
The main melatonin receptors are two G-protein coupled receptors named MT(1) and MT(2). Having described the molecular pharmacology of the human versions of these receptors, we turned to two of the three species most useful in studying melatonin physiology: rat and sheep (a diurnal species used to understand the relationship between circadian rhythm and depression). We also employed previously used compounds to describe the mouse melatonin receptors; despite the early cloning of mouse receptors, few molecular pharmacology studies on these receptors exist. To our surprise, we detected no major differences between the data obtained from mice and those from other species.
INRA, UMR85 Physiologie de Reproduction et des Comportements, F-37380 Nouzilly, France.
Séverine
S
Devavry
Céline
C
Legros
Chantal
C
Brasseur
William
W
Cohen
Sophie-Pénélope
SP
Guenin
Philippe
P
Delagrange
Benoît
B
Malpaux
Christine
C
Ouvry
Francis
F
Cogé
Olivier
O
Nosjean
Jean A
JA
Boutin
D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D023281:Genomics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D021381:Protein Transport; D051381:Rats; D044122:Receptor, Melatonin, MT1 / Q000737:chemistry* / Q000378:metabolism*; D044123:Receptor, Melatonin, MT2 / Q000737:chemistry* / Q000378:metabolism*; D016415:Sequence Alignment; D012756:Sheep; D013045:Species Specificity
D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2