Neuromuscular complications in HIV: effects of aging.
There has been speculation that chronic HIV infection is a condition of accelerated aging that may lead to early onset of disease in multiple organ systems. The neuromuscular disorders of HIV, in particular distal symmetric polyneuropathy and myopathies, are also seen in the general population among older patients. As the HIV-infected population ages, there may be deleterious synergistic effects of age and chronic HIV infection on the brain, peripheral nerve, and muscle. In this review, we explore commonalities between the clinical features and putative mechanisms of neuromuscular disorders and HIV.
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA. jessica.robinson-papp@mssm.edu
Jessica
J
Robinson-Papp
Ik Lin
IL
Tan
David M
DM
Simpson
D000375:Aging; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008017:Life Expectancy; D018482:Muscle, Skeletal / Q000503:physiopathology; D009437:Neuralgia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D009468:Neuromuscular Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology
D000700:Analgesics; D019380:Anti-HIV Agents