The chlorophyll catabolite pheophorbide a as a photosensitizer for the photodynamic therapy.
Pheophorbide a is a clorophyll catabolite that recently has drawn the attention of several investigators for its potential in photodynamic therapy. In this review we summarize its photophysical properties, phototoxicity, cellular localization, biodistribution and PDT activity as a free or conjugated molecule.
Department of Medical and Biological Sciences, P.le Kolbe 4, School of Medicine, 33100 Udine, Italy. luigi.xodo@uniud.it
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Xodo
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Rapozzi
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Zacchigna
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Drioli
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Zorzet
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D002352:Carrier Proteins / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D017319:Photosensitizing Agents; D002734:Chlorophyll; C032623:pheophorbide a