A comparative clinical study focusing on the antimicrobial efficacies of chlorhexidine gluconate alcohol for patient skin preparations.
Comparative efficacy study data showed that skin preparations formulated with more than 0.5% chlorhexidine gluconate (CHG) in alcohol produced significant reductions in microbial populations at the inguinal, abdominal, and antecubital sites at each sample time (P < .05) relative to baseline, and there were no significant differences statistically, including persistent effects within 24 hours (P > .05). It would be reasonable to expect that a 1% CHG-ethanol skin preparation (with >0.5% CHG in alcohol) could be chosen in Japan that would perform well and have promising potential for catheter preparation/maintenance preparation with consideration for recommendation of the Centers for Disease Control and Prevention's guideline issued in 2011.
Yoshida Pharmaceutical Co, Ltd, Tokyo, Japan. nishihara_yutaka@yoshida-pharm.co.jp
Yutaka
Y
Nishihara
Takumi
T
Kajiura
Katsuhiro
K
Yokota
Hiroyoshi
H
Kobayashi
Takashi
T
Okubo
D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015169:Colony Count, Microbial; D006801:Humans; D007564:Japan; D055624:Methicillin-Resistant Staphylococcus aureus; D005791:Patient Care; D012867:Skin / Q000187:drug effects / Q000382:microbiology*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine