Optimal cutoff points for body mass index, waist circumference and HOMA-IR to identify a cluster of cardiometabolic abnormalities in normal glucose-tolerant Brazilian children and adolescents.
OBJECTIVE
The aim of this study was to establish the best cutoff values for waist circumference (WC), body mass index (BMI) and HOMA-IR (HR) to identify a cluster (≥ 3) of cardiovascular risk factors (CVRF) in normal glucose-tolerant (NGT) Brazilian children and adolescents.


METHODS
Cross-sectional study of 319 individuals (aged 10 to 19y) from a southern Brazilian city. Gender-specific receiver-operating characteristics (ROC) curves were constructed to assess cutoffs values of BMI (kg/m(2), WC (cm), and HR.


RESULTS
The areas under the ROC curves to detect a cluster of CVRF were 0.92, 0.93 and 0.68 (females), and 0.93, 0.93 and 0.89 (males), for WC, BMI and HR, respectively. The cutoff values were 83.0 and 80.5 cm (WC), 22.7 and 20.4 kg/m(2) (BMI), and 1.65 and 1.95 (HR), for females and males, respectively, to detect the cluster of CVRF.


CONCLUSIONS
These values of BMI, WC-) and (HR) detected a high proportion of NGTt Brazilian children and adolescents with a cluster of CVRF.
Endocrinology Division and Diabetes Cente, Universidade Federal de São Paulo, Brazil.
Eloa R
ER
Rocco
Denise Barretto
DB
Mory
Carla Sanchez
CS
Bergamin
Fernando
F
Valente
Valquíria Lopes
VL
Miranda
Bruno Frederico Aguilar
BF
Calegare
Regina Quirino
RQ
Silva
Sérgio Atala
SA
Dib
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D012016:Reference Values; D017678:Sex Distribution; D055105:Waist Circumference / Q000502:physiology*; D055815:Young Adult
D001786:Blood Glucose