Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test.
OBJECTIVE
To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay.


METHODS
This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration.


RESULTS
Using the UBT as the standard, the sensitivity, specificity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were significantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A(450/630)) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099).


CONCLUSIONS
The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.
Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu city, Oita 879-5593, Japan. kodm@oita-u.ac.jp
Masaaki
M
Kodama
Kazunari
K
Murakami
Tadayoshi
T
Okimoto
Yoshihiro
Y
Fukuda
Tadashi
T
Shimoyama
Masumi
M
Okuda
Chieko
C
Kato
Intetsu
I
Kobayashi
Toshio
T
Fujioka
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial; D001944:Breath Tests / Q000379:methods; D005243:Feces / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D014508:Urea
D000942:Antigens, Bacterial; D054328:Proton Pump Inhibitors; D014508:Urea