The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections.
Herpes simplex virus (HSV) establishes latent infections in sensory neurons from which it can periodically reactivate and cause recurrent disease and transmission to new hosts. Little is known about the virally encoded mechanisms that influence the maintenance of HSV latent infectious and modulate the frequency of virus reactivation from the latent state. Here, we report that the latency associated transcript locus of HSV-1 is required for long-term maintenance of reactivation competent latent infections.
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0524, USA. richard.thompson@uc.edu
Richard L
RL
Thompson
Nancy M
NM
Sawtell
D000818:Animals; D015967:Gene Expression Regulation, Viral; D056426:Genetic Loci; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D012333:RNA, Messenger / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D011984:Sensory Receptor Cells / Q000821:virology; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014775:Virus Activation / Q000235:genetics*; D017735:Virus Latency / Q000235:genetics; D014779:Virus Replication / Q000502:physiology
D035683:MicroRNAs; D012333:RNA, Messenger; D012367:RNA, Viral; C477253:latency associated transcript, herpes simplex virus-1