An immunoglobulin G4-related disease mimicking postoperative lung cancer recurrence.
A postoperative lung cancer patient presented with lymphadenopathy, pleural thickening, and 18F-fluorodeoxyglucose (FDG) uptake on a positron emission tomography-computed tomography (PET-CT) scan. Lung cancer recurrence was initially suspected, but bilateral submandibular masses with 18F-FDG uptake indicated the possibility of a systemic disease, such as Mikulicz's disease. High serum immunoglobulin G4 (IgG4) and IgG4-positive plasma cell infiltration in the submandibular glands led to the diagnosis of IgG4-related disease. After systemic steroid therapy, 18F-FDG uptake decreased in both the submandibular glands and the suspected recurrent lesions.
Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Seshiru
S
Nakazawa
Kimihiro
K
Shimizu
Tetsuhiro
T
Nakano
Seiichi
S
Kakegawa
Jun
J
Atsumi
Mitsuhiro
M
Kamiyoshihara
Junko
J
Hirato
Izumi
I
Takeyoshi
D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008206:Lymphatic Diseases / Q000473:pathology; D008297:Male; D008882:Mikulicz' Disease / Q000175:diagnosis; D064847:Multimodal Imaging / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010950:Plasma Cells / Q000473:pathology; D010994:Pleura / Q000473:pathology; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use; D013363:Submandibular Gland / Q000473:pathology; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D007074:Immunoglobulin G; D019788:Fluorodeoxyglucose F18; D011239:Prednisolone