Novel insights into the role of caveolin-2 in cell- and tissue-specific signaling and function.
Caveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions.
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
Grzegorz
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Sowa