[Fibromyalgia in adults-a mainly psychosomatic entity].
This paper presents the clinical entity of fibromyalgia and is a review of the research data on its  pathogenesis and treatment. Current data indicate that bio-genetic factors associated mainly with  the mechanisms of pain, combined with serious stressfull experiences, may be responsible for  causing the disease. The contribution of neurotransmitters (such as substance P), of hormones (in  particular  of  the  hypothalamus-pituitar y  axis),  of  sleep  disturbance,  of  brain  circuits  linked  to  the  perception of pain is discussed. The treatment of fibromyalgia is complex and involves in particular  antidepressant therapy in combination with psychoeducational cognitive and behavioral interventions and rehabilitation programs. In the diagnosis and treatment of the disease, which, without  assistance can become torturing, many specialties of health professionals are involved.
Rheumatological Outpatient Clinic University Hospital of Alexandroupolis, Alexandroupolis, Greece.
N G
NG
Galanopoulos
D N
DN
Artemis
H
H
Konstanidis
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M
Leivaditis