Wnt/planar cell polarity signaling in the regulation of convergent extension movements during Xenopus gastrulation.
The Wnt/planar cell polarity (PCP) signaling pathway plays a critical role in wing, eye, neural tube defects, and sensory bristle development of Drosophila and vertebrate development. Recently, the Wnt/PCP pathway has been known to regulate convergent extension (CE) movements that are essential for establishing the three germ layers and body axis during early vertebrate development. Here, we describe detailed practical procedures required for the particular studies in Xenopus CE movements.
Division of Life Science, Korea Basic Science Institute, Daejeon, Republic of Korea. genekgh@kbsi.re.kr
Gun-Hwa
GH
Kim
Edmond Changkyun
EC
Park
Jin-Kwan
JK
Han
D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D005260:Female; D005307:Fertilization in Vitro; D054262:Gastrulation; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008845:Microinjections; D008855:Microscopy, Electron, Scanning; D010062:Ovulation Induction; D010063:Ovum; D010641:Phenotype; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D014982:Xenopus laevis / Q000196:embryology* / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D051153:Wnt Proteins; D048031:JNK Mitogen-Activated Protein Kinases; D020742:rhoA GTP-Binding Protein