Females with angina pectoris have altered lipoprotein metabolism with             elevated cholesteryl ester transfer protein activity and impaired high-density             lipoproteins-associated antioxidant enzymes.
In order to investigate non-invasive biomarkers for angina pectoris (AP),             we analyzed the lipid and protein composition in individual lipoproteins from             females with angina pectoris (n=22) and age- and gender-matched controls (n=20).             In the low-density lipoprotein (LDL) fraction, the triglycerides (TG) and protein             content increased in the AP group compared to the control group. The AP group             had lower total cholesterol (TC) and elevated TG in the high-density lipoprotein             (HDL) fraction. In the AP group, cholesteryl ester transfer protein (CETP) activity             was enhanced in HDL and LDL, while lecithin:cholesterol acyltransferase (LCAT)             activity in HDL3 was almost depleted. Antioxidant activity was significantly decreased             in the HDL3 fraction, with a decrease in the HDL2 particle size. In the HDL3 fraction,             paraoxonase and platelet activating factor-acetylhydrolase (PAF-AH) activity were             much lower and the levels of CETP and apoC-III were elevated in the AP group.             The LDL from the AP group was more sensitive to cupric ion-mediated oxidation             with faster mobility. In conclusion, the lipoprotein fractions in the AP group             had impaired antioxidant activity and increased TG and apoC-III with structural             and functional changes.
School of Biotechnology, Yeungnam University, Gyeongsan 712-749,                     Rebublic of Korea.
Jungho
J
Park
Jae-Ryong
JR
Kim
Dong-Gu
DG
Shin
Kyung-Hyun
KH
Cho
D000787:Angina Pectoris / Q000503:physiopathology*; D000975:Antioxidants / Q000378:metabolism*; D053305:Apolipoprotein C-III / Q000235:genetics / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000378:metabolism; D054709:Lecithins / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D000975:Antioxidants; D053305:Apolipoprotein C-III; D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D054709:Lecithins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010972:Platelet Activating Factor; D014280:Triglycerides; D043303:Aryldialkylphosphatase