The prognostic value of serum gamma glutamyl transferase activity on admission in patients with STEMI undergoing primary PCI.
We assessed the association between serum gamma glutamyl transferase (GGT) activity with postprimary percutaneous coronary intervention (PCI) coronary flow and in-hospital major advanced cardiac events (MACEs) in patients with ST elevation myocardial infarction (STEMI). Patients with STEMI (n = 425; males 78%; mean age 60 ± 13 years) were enrolled. Patients were divided into 3 GGT tertiles and 2 groups according to thrombolysis in myocardial infarction (TIMI) flow grade. The TIMI flow percentages were similar in the 3 GGT tertiles (32%, 45%, and 42%, respectively, P = .336). Total MACE increased with GGT tertiles (among tertiles, respectively; P < .001). The total MACE was significantly higher in impaired flow group than in normal flow group (23% vs 7%; P < .001). At multivariate analyses, serum GGT activity was an independent predictor of in-hospital MACE (odds ratio [OR] 1.12, 95% confidence interval [CI] 1.01-1.33; P < .001). In conclusion, serum GGT activity is associated with in-hospital MACE in patients with STEMI undergoing primary PCI.
Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. mahmutapek@yahoo.com
Mahmut
M
Akpek
Deniz
D
Elcik
Nihat
N
Kalay
Mikail
M
Yarlioglues
Orhan
O
Dogdu
Omer
O
Sahin
Idris
I
Ardic
Abdurrahman
A
Oguzhan
Ali
A
Ergin
Mehmet G
MG
Kaya
D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000628:therapy; D010343:Patient Admission; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D012039:Regional Blood Flow; D016896:Treatment Outcome; D005723:gamma-Glutamyltransferase / Q000097:blood*
D005723:gamma-Glutamyltransferase