Rat models of prenatal and adolescent cannabis exposure.
Marijuana (Cannabis sativa) is the illicit drug most commonly used by two vulnerable populations relevant to neurodevelopment-pregnant women and teenagers. Human longitudinal studies have linked prenatal and adolescent cannabis exposure with long-term behavioral abnormalities as well as increased vulnerability to neuropsychiatric disorders in adulthood. Animal models provide a means of studying the neurobiological mechanisms underlying these long-term effects. This chapter provides an overview of the animal models we have used to study the developmental impact of cannabis.
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Jennifer A
JA
Dinieri
Yasmin L
YL
Hurd
D000293:Adolescent; D000818:Animals; D002188:Cannabis / Q000009:adverse effects*; D013759:Dronabinol / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse; D023421:Models, Animal; D009420:Nervous System / Q000187:drug effects / Q000196:embryology; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology; D051381:Rats; D020318:Rats, Long-Evans; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D013759:Dronabinol