Results of a new human recombinant thrombin for the treatment of arterial pseudoaneurysm.
OBJECTIVE
To evaluate the results of a new thrombin sealant (Recothrom) for the treatment of arterial pseudoaneurysms (PDAs).


METHODS
We reviewed 47 consecutive patients prospectively entered in a dedicated data set who underwent ultrasound-guided percutaneous thrombin injection to treat PDA. End points were PDA recurrence, need for reintervention, and related complications such as limb ischemia or allergic reactions.


RESULTS
Twenty-six patients were females (55%) and the median age of the entire group was 71 years (range, 45-87). The mean size of the PDA was 2.3 ± 0.9 cm. The mean injected volume was 2.4 ± 1.4 mL containing 500 ± 320 units. Recurrence of the PDA occurred in 4 (8.5%) patients and was not related to anticoagulation status, body habitus, platelets levels, or use of antiplatelets. All recurred PDAs were successfully sealed with a second (n = 3) and a third injection (n = 1). There was no distal embolization or allergic reactions and no surgical intervention was required.


CONCLUSIONS
The new human recombinant thrombin (Recothrom) is a safer nonimmunogenic option with similar success rates of other fibrin glue sealants.
Division of Vascular Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794, USA. rmalgor@sbumed.org
Rafael D
RD
Malgor
Nicos
N
Labropoulos
Antonios P
AP
Gasparis
David S
DS
Landau
Apostolos K
AK
Tassiopoulos
D000368:Aged; D000369:Aged, 80 and over; D017541:Aneurysm, False / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009518:New York; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage; D012008:Recurrence; D013917:Thrombin / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D018084:Ultrasonography, Interventional
D015718:Fibrin Tissue Adhesive; D011994:Recombinant Proteins; D013917:Thrombin