[Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer].
OBJECTIVE
To evaluate the clinical significance of blood and fecal expression of tumor M2-pyruvate kinase (Tumor M2-PK) in patients with colorectal cancer.


METHODS
With 22 healthy subjects as controls, 44 patients with CRC were examined for tumor M2-PK in serum and fecal samples using a sandwich enzyme immunoassay.


RESULTS
The sensitivity of serum and fecal tumor M2-PK for detecting CRC was 59.1% and 63.6% with a specificity of 86.4% and 81.8%, respectively. The serum and fecal levels of tumor M2-PK showed a significant correlation in CRC patients.


CONCLUSIONS
Tumor M2-PK has good sensitivity and specificity in the diagnosis of CRC.
Department of Gastrointestinal Surgery, Guangdong Academy of Medical Sciences, Guangzhou, China. liyong-lucky@21cn.com
Yong
Y
Li
Jun-jiang
JJ
Wang
D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D011770:Pyruvate Kinase / Q000097:blood* / Q000378:metabolism*
D014408:Biomarkers, Tumor; D011770:Pyruvate Kinase