Noble metal nanoparticles in DNA detection and delivery.
DNA-conjugated metal nanoparticles have attracted enormous attention for biological and medical applications, owing to their unusual DNA melting characteristics as well as unique optical and catalytic properties. The combination of these unique properties has not only led to the development of DNA-detection technologies with remarkably high selectivity and sensitivity, but also to the development of gene therapeutic agents with high efficacy and efficiency. In this review, we present a comprehensive coverage on their applications in detecting, manipulating, and delivering genes.
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Xi-Jun
XJ
Chen
Brenda L
BL
Sanchez-Gaytan
Zhaoxia
Z
Qian
So-Jung
SJ
Park
D000818:Animals; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013057:Spectrum Analysis
D012834:Silver; D006046:Gold; D004247:DNA