Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population.
Risperidone non-compliance is often high due to undesirable side effects, whose development is in part genetically determined. Studies with genetic variants involved in the pharmacokinetics and pharmacodynamics of risperidone have yielded inconsistent results. Thus, the aim of this study was to investigate the putative association of genetic markers with the occurrence of four frequently observed adverse events secondary to risperidone treatment: sleepiness, weight gain, extrapyramidal symptoms and sexual adverse events. A series of 111 schizophrenia inpatients were genotyped for genetic variants previously associated with or potentially involved in risperidone response. Presence of adverse events was the main variable and potential confounding factors were considered. Allele 16Gly of ADRB2 was significantly associated with a higher risk of sexual adverse events. There were other non-significant trends for DRD3 9Gly and SLC6A4 S alleles. Our results, although preliminary, provide new candidate variants of potential use in risperidone safety prediction.
Department of Genetics and Genomics, CAIBER Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain.
B
B
Almoguera
R
R
Riveiro-Alvarez
J
J
Lopez-Castroman
P
P
Dorado
C
C
Vaquero-Lorenzo
J
J
Fernandez-Piqueras
A
A
Llerena
F
F
Abad-Santos
E
E
Baca-García
R
R
Dal-Ré
C
C
Ayuso
D000483:Alleles; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced / Q000473:pathology; D056726:Genetic Association Studies; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
C553443:ADRB2 protein, human; C493593:DRD3 protein, human; D018343:Receptors, Adrenergic, beta-2; D050637:Receptors, Dopamine D3; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D018967:Risperidone