Musculoskeletal manifestation in the joints of the diabetic animal model Otsuka Long-Evans Tokushima fatty rat: a histological study.
Diabetes mellitus (DM) is a chronic metabolic disease and is associated             with vascular complications. However, the association of musculoskeletal manifestations             and DM is not clear. We investigated musculoskeletal manifestations in the diabetic             animal model Otsuka Long-Evans Tokushima Fatty (OLETF) rat. OLETF rats and control             LETO (Long-Evans Tokushima Otsuka) rats at two different ages (44 and 95 weeks)             were used. Knee joints and ankles with interphalangeal joints were removed, dissected,             stained with hematoxylin and eosin (H&E), periodic acid-Schiff, methenamine             silver, and Masson-trichrome staining and examined under light microscopy. Mild             degenerative changes with focal edema and mild fibrosis were noted in OLETF rats             (at 95 weeks of age) and in age-matched LETO rats, particularly in the interphalangeal             joints. Necrosis, phagocytosis of necrotic fibers, regeneration, mononuclear inflammatory             cell infiltration, granulation tissue, calcification and cartilage erosion were             not observed in either the aged diabetic or the non-diabetic group. We found no             prominent musculoskeletal manifestations in the OLETF rats. The reasons may be             due to the low prevalence rate of these anomalies, or the life span of rats may             be too short to express these alterations. More studies are needed to elucidate             the pathophysiological mechanisms by demonstrating the musculoskeletal manifestations             histologically.
East-West Bone and Joint Research Institute, Kyung Hee University, Seoul, Republic of Korea. labrea46@yahoo.co.kr
Kyoung Soo
KS
Kim
In-Kyung
IK
Jeong
Sang-Hoon
SH
Lee
Ran
R
Song
Hyung-In
HI
Yang
Jung Yeon
JY
Kim
D000818:Animals; D000842:Ankle / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004487:Edema / Q000209:etiology / Q000473:pathology; D005355:Fibrosis / Q000209:etiology / Q000473:pathology; D007719:Knee Joint / Q000473:pathology; D008297:Male; D009140:Musculoskeletal Diseases / Q000209:etiology*; D051381:Rats; D020332:Rats, Inbred LEC; D020334:Rats, Inbred OLETF