High resolution manometric findings in patients with Chagas' disease esophagopathy.
OBJECTIVE
To describe high resolution manometry features of a population of symptomatic patients with Chagas' disease esophagopathy (CDE).


METHODS
Sixteen symptomatic dysphagic patients with CDE [mean age (54.81±13.43) years, 10 women] were included in this study. All patients underwent a high resolution manometry.


RESULTS
Mean lower esophageal sphincter (LES) extension was (3.02±1.17) cm with a mean basal pressure of (15.25±7.00) mmHg. Residual pressure was (14.31±9.19) mmHg. Aperistalsis was found in all 16 patients. Achalasia with minimal esophageal pressurization (type 1) was present in 25% of patients and achalasia with esophageal compression (type 2) in 75%, according to the Chicago Classification. Upper esophageal sphincter (UES) mean basal pressure was (97.96±54.22) mmHg with a residual pressure of (12.95±6.42) mmHg.


CONCLUSIONS
Our results show that LES was hypotensive or normotensive in the majority of the patients. Impaired relaxation was found in a minority of our patients. Aperistalsis was seen in 100% of patients. UES had impaired relaxation in a significant number of patients. Further clinical study is needed to investigate whether manometric features can predict outcomes following the studies of idiopathic achalasia.
Department of Surgery, Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil.
Luciana C
LC
Silva
Fernando P P
FP
Vicentine
Fernando A M
FA
Herbella
D000818:Animals; D014355:Chagas Disease / Q000150:complications / Q000503:physiopathology*; D003680:Deglutition Disorders / Q000469:parasitology / Q000503:physiopathology*; D004931:Esophageal Achalasia / Q000469:parasitology / Q000503:physiopathology*; D049630:Esophageal Sphincter, Lower / Q000469:parasitology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis; D014349:Trypanosoma cruzi / Q000472:pathogenicity*