Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response.
The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7 T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.
Cognitive Science Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands. b.u.forstmann@uva.nl
Birte U
BU
Forstmann
Max C
MC
Keuken
Sara
S
Jahfari
Pierre-Louis
PL
Bazin
Jane
J
Neumann
Andreas
A
Schäfer
Alfred
A
Anwander
Robert
R
Turner
D000328:Adult; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008297:Male; D011930:Reaction Time; D020531:Subthalamic Nucleus / Q000502:physiology*; D055815:Young Adult