Sustained release microspheres of ropinirole hydrochloride: effect of process parameters.
An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 32 full factorial design. The microspheres were made by incorporating the drug in a polar organic solvent, which was emulsified using liquid paraffin as an external oil phase. Effects of various process parameters such as viscosity of the external phase, selection of the internal phase, surfactant selection and selection of stirring speed were studied. Microspheres were evaluated for product yield, encapsulation efficiency and particle size. Various drug/ethylcellulose ratios and PEG concentrations were assayed. In vitro dissolution profiles showed that ethylcellulose microspheres were able to control release of the drug for a period of 12 h.
Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-411041 (MS), India. prof_avachat@yahoo.com
Amelia M
AM
Avachat
Pralhad N
PN
Bornare
Rakesh R
RR
Dash
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D007211:Indoles / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008863:Microspheres; D010316:Particle Size; D012995:Solubility / Q000187:drug effects; D014783:Viscosity / Q000187:drug effects
D003692:Delayed-Action Preparations; D007211:Indoles; C046649:ropinirole