Toxicokinetic of benzo[a]pyrene and fipronil in female green frogs (Pelophylax kl. esculentus).
A general consensus that an increased logK(ow) led to an increase in xenobiotic uptake and bioaccumulation is accepted. In this study we compared the toxicokinetics of two chemically different xenobiotics, i.e. benzo[a]pyrene and fipronil in female green frogs. Surprisingly, the uptake rates and the bioconcentration factors (BCF) of the two contaminants were not predicted by their logK(ow). The uptake rates obtained were of the same order of magnitude for the two contaminants and the BCFs measured for fipronil were about 3-fold higher than those obtained for benzo[a]pyrene. Fipronil appeared to be more recalcitrant than benzo[a]pyrene to detoxification processes leading to the accumulation of sulfone-fipronil especially in the ovaries. This phenomenon may explain reproductive influence of this contaminant described in other studies. Detoxification processes, including metabolism and the excretion of pollutants, are of importance when considering their persistence in aquatic organisms and trying to quantify their risks.
Laboratoire d'Ecologie Alpine (LECA, UMR 5553 CNRS-Université), Equipe « Pollution Environnement Ecotoxicologie Ecoremediation » Domaine Universitaire de Saint-Martin d'Hères. 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France. stephane.reynaud@ujf-grenoble.fr
Stéphane
S
Reynaud
Isabelle A M
IA
Worms
Sylvie
S
Veyrenc
Julien
J
Portier
Anne
A
Maitre
Claude
C
Miaud
Muriel
M
Raveton
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D015386:Hazardous Substances / Q000378:metabolism / Q000633:toxicity*; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity*; D011720:Pyrazoles / Q000378:metabolism / Q000633:toxicity*; D011893:Rana esculenta / Q000502:physiology*; D015262:Xenobiotics / Q000378:metabolism / Q000633:toxicity
D015386:Hazardous Substances; D007306:Insecticides; D011720:Pyrazoles; D015262:Xenobiotics; D001564:Benzo(a)pyrene; C082360:fipronil