Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin.
In this study, doxorubicin (DOX)-loaded long circulating liposomes combined with curcumin (CUR) (DOX-CUR-LCLs) were successfully prepared as a novel formulation for cancer treatment. The particle size and distribution, zeta potential, drug loading capacity, and entrapment efficiency (EE) of the preparation were characterized. The in vitro anti-tumor activities of DOX-CUR-LCLs and DOX-LCLs against A549 cells were then evaluated and compared with that of free DOX. Cytotoxicity evaluation showed that DOX-CUR-LCLs had a significantly higher antitumor activity than other DOX preparations. These results suggest that novel DOX-CUR-LCLs, combination of DOX and CUR administered in long-circulating liposomes, could improve antitumor activity.
Hebei Medical University, Baoding, Hebei Province, P. R. China. bossw@vip.sina.com
Hong
H
Wang
Liandong
L
Hu
Chunlei
C
Li
Jingguo
J
Zhang
Tao
T
Zhang
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use*; D001808:Blood Vessels / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use*; D004339:Drug Compounding; D004431:Ear, External / Q000187:drug effects / Q000473:pathology; D006461:Hemolysis; D066298:In Vitro Techniques; D007509:Irritants; D008081:Liposomes; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D007509:Irritants; D008081:Liposomes; D004317:Doxorubicin; D003474:Curcumin