Appraisal of the porcine kidney autotransplantation model.
Animal models are extensively used for transplantation related research, especially kidney transplantation. Porcine autotransplantation models are considered to be favorable regarding translatability to the human setting. The key determinants for translatability of the model are discussed, comprising animal age, development, anatomy, anesthesia and surgical protocols, and perioperative care. With the detailed discussion of these determinants and the pitfalls in diagnosing animal discomfort, an attempt is made to provide a uniform porcine kidney autotransplantation model with tools to improve currently used models.
Department of Surgery (Surgical Laboratory), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Ivo C J H
IC
Post
Marcel C
MC
Dirkes
Michal
M
Heger
Johannes P A M
JP
van Loon
Bas
B
Swildens
Goos M
GM
Huijzer
Thomas M
TM
van Gulik
D000367:Age Factors; D000758:Anesthesia; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016030:Kidney Transplantation; D008297:Male; D011182:Postoperative Care; D013552:Swine