Heat shock proteins (HSP): dermatological implications and perspectives.
In recent years, several studies have demonstrated the protective effect of Heat Shock Proteins (HSP) on different organs and tissues under stressful conditions. However, most research explores the performance of those molecular chaperones during immune responses or pathological conditions like cancer, whereas the number of studies related to the performance of HSPs in the skin during diverse natural or physiopathological conditions is very low. Therefore, the aim of this article was to summarize the main concepts concerning the expression and performance of HSPs, from analysis of current medicine and cosmetics publications, as well as exploring the importance of these proteins in the dermatological area in physiological events such as cutaneous aging, skin cancer and wound healing and to present final considerations related to biotechnology performance in this area.
Laboratório de Controle Biológico de Qualidade de Medicamentos e Cosméticos - Universidade de São Paulo, Av. Prof. Lineu Prestes 580, Bloco 13, São Paulo, Brasil. wmagalhaes@usp.br
Wagner
W
Vidal Magalhães
Marcelo Fábio
MF
Gouveia Nogueira
Telma Mary
TM
Kaneko
D006360:Heat-Shock Proteins / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D012867:Skin / Q000378:metabolism*; D015595:Skin Aging; D012878:Skin Neoplasms / Q000378:metabolism*; D014945:Wound Healing
D006360:Heat-Shock Proteins