Rhenium-catalyzed regiodivergent addition of indoles to terminal alkynes.
An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.
Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Dexin
D
Xia
Yin
Y
Wang
Zhenting
Z
Du
Qi-Yu
QY
Zheng
Congyang
C
Wang
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D007211:Indoles; D012211:Rhenium