New 6-hydroxyeunicellins from a soft coral Cladiella sp.
Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Yung-Husan
YH
Chen
Tsong-Long
TL
Hwang
Yin-Di
YD
Su
Yu-Chia
YC
Chang
Yu-Hsin
YH
Chen
Pei-Han
PH
Hong
Li-Chung
LC
Hu
Wei-Hsuan
WH
Yen
Hsin-Yin
HY
Hsu
Shu-Jung
SJ
Huang
Yueh-Hsiung
YH
Kuo
Ping-Jyun
PJ
Sung
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
C571695:6-epi-cladieunicellin F; D004224:Diterpenes; C571694:cladieunicellin G; D013481:Superoxides; D010196:Pancreatic Elastase