Equine herpesvirus type 1-mediated oncolysis of human glioblastoma multiforme cells.
The cytolytic animal virus equine herpesvirus type 1 (EHV-1) was evaluated for its oncolytic potential against five human glioblastoma cell lines. EHV-1 productively infected four of these cell lines, and the degree of infection was positively correlated with glioma cell death. No human major histocompatibility complex class 1 (MHC-I) was detected in the resistant glioma line, while infection of the susceptible glioma cell lines, which expressed human MHC-I, were blocked with antibody to MHC-I, indicating that human MHC-I acts as an EHV-1 entry receptor on glioma cells.
Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, North Carolina, USA.
Michael J
MJ
Courchesne
Maria C
MC
White
Brent A
BA
Stanfield
Arthur R
AR
Frampton
D001932:Brain Neoplasms / Q000628:therapy / Q000821:virology*; D045744:Cell Line, Tumor; D005909:Glioblastoma / Q000628:therapy / Q000821:virology*; D004861:Herpesvirus 1, Equid / Q000235:genetics / Q000502:physiology*; D006801:Humans; D050130:Oncolytic Virotherapy / Q000295:instrumentation*; D050504:Oncolytic Viruses / Q000235:genetics / Q000502:physiology*