Modulation of cell cycle regulators by HDACs.
Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues on histones and non-histone proteins. HDACs have been shown to control the functions of key cell cycle proteins. Consistent with this, the overexpression of HDACs has been observed in multiple cancers, resulting in deregulation of the cell cycle and uncontrolled proliferation. This review focuses on the impact that HDACs have on cell cycle control through the deacetylation of proteins.
Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Elphine
E
Telles
Edward
E
Seto
D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D048708:Cell Growth Processes / Q000502:physiology; D006655:Histone Deacetylases / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*
D018797:Cell Cycle Proteins; D006657:Histones; D006655:Histone Deacetylases; D008239:Lysine