Collision of three histologically distinct endometrial cancers of the uterus.
A collision tumor is defined by the presence of two separate masses in one organ, which are pathologically distinct. We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed müllerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcinoma component invaded the underlying myometrium and metastasized to the regional lymph node. Adjuvant chemotherapy and radiation therapy were performed. The patient is still alive and has been healthy for the last 8 yr. We have reviewed previously reported cases of collision tumors which have occurred in the uterine corpus.
Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
Ki-Seok
KS
Jang
Won-Moo
WM
Lee
Young-Jae
YJ
Kim
Sam-Hyun
SH
Cho
D000368:Aged; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018283:Cystadenocarcinoma, Papillary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D000077289:Letrozole; D008207:Lymphatic Metastasis; D018200:Mixed Tumor, Mullerian / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009570:Nitriles / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D016159:Tumor Suppressor Protein p53; D007633:Keratins; D000077289:Letrozole