Glutaraldehyde-induced colitis: case reports and literature review.
Glutaraldehyde-induced colitis is an uncommon colitis in clinical practice. Because the involvement of colonic segment is determined by the endoscopic part where glutaraldehyde remains, a recent history of endoscopy and a demarcated involvement of colonic segment are the most characteristic signs of glutaraldehyde-induced colitis. The typical clinical scenario is acute onset of lower abdominal pain, fever, and bloody stool. Laboratory data usually show leukocytosis and elevated C-reactive protein. The endoscopic pictures of involved segments are compatible with acute colitis, including hyperemic, edematous, with or without multiple erosions. Acute ischemic colitis and infectious colitis should be differentiated at the outset of the disease. Stool pathogen tests are usually negative. Parenteral empiric antibiotic may be considered if severe transmural edema of the involved segment is observed in computed tomography. Conservative treatment, including bowel rest and parenteral hydration, is able to stabilize the condition in a week. Herein, we present two cases of acute proctocolitis caused by glutaraldehyde after uneventful colonoscopy.
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hsiang-Yao
HY
Shih
Deng-Chyang
DC
Wu
Wan-Ting
WT
Huang
Yong-Yu
YY
Chang
Fang-Jung
FJ
Yu
D000208:Acute Disease; D000328:Adult; D003106:Colon / Q000000981:diagnostic imaging / Q000473:pathology; D003113:Colonoscopy / Q000009:adverse effects*; D004202:Disinfectants / Q000009:adverse effects*; D005260:Female; D005976:Glutaral / Q000009:adverse effects*; D006801:Humans; D011350:Proctocolitis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D055815:Young Adult
D004202:Disinfectants; D005976:Glutaral