Advances in Aspergillus secondary metabolite research in the post-genomic era.
This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.
University of Southern California-Pharmacology and Pharmaceutical Sciences, Los Angeles, California 90033, USA.
James F
JF
Sanchez
Amber D
AD
Somoza
Nancy P
NP
Keller
Clay C C
CC
Wang
D001230:Aspergillus / Q000235:genetics* / Q000378:metabolism; D016681:Genome, Fungal; D006801:Humans; D015394:Molecular Structure