Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications.
Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.
Department of Pathology, Hippokration General Hospital of Thessaloniki, 54642 Thessaloniki, Greece.
Thomas G
TG
Papathomas
Ioannis
I
Venizelos
Cherie H
CH
Dunphy
Jonathan W
JW
Said
Michael L
ML
Wang
Elias
E
Campo
Steven H
SH
Swerdlow
John C
JC
Chan
Carlos E
CE
Bueso-Ramos
Dennis D
DD
Weisenburger
L Jeffrey
LJ
Medeiros
Ken H
KH
Young
D058617:Composite Lymphoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008297:Male