Accurate prediction of cardiorespiratory fitness using cycle ergometry in minimally disabled persons with relapsing-remitting multiple sclerosis.
OBJECTIVE
To examine the accuracy of predicting peak oxygen consumption (VO(2peak)) primarily from peak work rate (WR(peak)) recorded during a maximal, incremental exercise test on a cycle ergometer among persons with relapsing-remitting multiple sclerosis (RRMS) who had minimal disability.


METHODS
Cross-sectional study.


METHODS
Clinical research laboratory.


METHODS
Women with RRMS (n=32) and sex-, age-, height-, and weight-matched healthy controls (n=16) completed an incremental exercise test on a cycle ergometer to volitional termination.


METHODS
Not applicable.


METHODS
Measured and predicted VO(2peak) and WR(peak).


RESULTS
There were strong, statistically significant associations between measured and predicted VO(2peak) in the overall sample (R(2)=.89, standard error of the estimate=127.4 mL/min) and subsamples with (R(2)=.89, standard error of the estimate=131.3 mL/min) and without (R(2)=.85, standard error of the estimate=126.8 mL/min) multiple sclerosis (MS) based on the linear regression analyses. Based on the 95% confidence limits for worst-case errors, the equation predicted VO(2peak) within 10% of its true value in 95 of every 100 subjects with MS.


CONCLUSIONS
Peak VO(2) can be accurately predicted in persons with RRMS who have minimal disability as it is in controls by using established equations and WR(peak) recorded from a maximal, incremental exercise test on a cycle ergometer.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. robmotl@uiuc.edu
Robert W
RW
Motl
Bo
B
Fernhall
D000328:Adult; D001642:Bicycling; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities / Q000534:rehabilitation*; D016552:Ergometry / Q000379:methods* / Q000706:statistics & numerical data; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance; D005260:Female; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology* / Q000534:rehabilitation*; D010101:Oxygen Consumption; D010809:Physical Fitness / Q000502:physiology*; D015203:Reproducibility of Results