Inflammation and antiangiogenesis in cancer.
The immune system regulates angiogenesis in cancer by means of pro- and anti-angiogenesis activities. In fact, both innate (macrophages, granulocytes, mast cells, dendritic cells, natural killer cells, and platelets) and adaptive (T and B lymphocytes) immune cells synthesize several pro- and anti-angiogenic mediators. Moreover, in pre-clinical models, a synergy has been observed between antiangiogenic molecules and immunotherapy. In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer.
Department of Basic Medical Sciences,University of Bari Medical School, Policlinico, Bari, Italy. ribatti@anatomia.uniba.it
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Ribatti
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Crivellato
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Vacca
D056704:Adaptive Immunity; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology
D020533:Angiogenesis Inhibitors