Characterization of interleukin-33 and soluble ST2 in serum and their association with disease severity in patients with chronic kidney disease.
BACKGROUND
This study aims to test the serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in patients with chronic kidney disease (CKD) and to evaluate their association with disease severity.


METHODS
Sixty-nine patients with CKD were enrolled, disease severity was assessed, and clinical data were collected. Twelve healthy volunteers served as healthy individuals. Serum IL-33 and sST2 were tested by enzyme-linked immunosorbent assay.


RESULTS
The patients were classified into five categories based on their estimated glomerular filtration rate (eGFR). No difference was found as to the serum concentration of IL-33 between CKD patients and healthy individuals (p = 0.656), while a higher serum level of sST2 was found in CKD patients (p = 0.003). The correlation analysis revealed a significant correlation between the serum level of sST2 and disease severity (r = 0.586; p < 0.001). A higher level of sST2 was found in CKD patients with elevated parathyroid hormone (p = 0.001). Serum sST2 correlated with parathyroid hormone (r = 0.412; p < 0.001), serum phosphorus (r = 0.545; p < 0.001), and serum calcium (r = -0.494; p < 0.001).


CONCLUSIONS
An elevated concentration of serum sST2 is found in CKD patients and correlates with disease severity. Serum sST2 may be also associated with parathyroid hormone disorder of CKD. The sST2 may have an important role in the development of CKD or as a marker of disease severity.
Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, No. 23 Youzheng Street, Harbin, China.
Yu-Shi
YS
Bao
Shi-Ping
SP
Na
Ping
P
Zhang
Xi-Bei
XB
Jia
Rui-Chan
RC
Liu
Cheng-Yuan
CY
Yu
Su-Hong
SH
Mu
Ru-Juan
RJ
Xie
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000276:immunology*; D012720:Severity of Illness Index; D055815:Young Adult
C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface