Risk factors for prolonged treatment of lymph node tuberculosis.
Lymph node tuberculosis (LNTB) is the most frequent form of extra-pulmonary tuberculosis (TB). Randomised, controlled trials have convincingly demonstrated that 6 months of chemotherapy is sufficient for most drug-susceptible LNTB. We performed a retrospective, multicentric study from  1997 to 2010 to describe factors associated with prolonged anti-tuberculosis treatment in patients with LNTB. Of 126 patients diagnosed with LNTB, 22 (17.5%) were human immunodeficiency virus (HIV) infected. The median treatment duration was 9 months (interquartile range, 6-12). Treatment  was significantly longer in patients with HIV (P < 0.01), additional sites of TB (P < 0.01) or weight loss (P = 0.04). Factors independently associated with excessively lengthy treatment were HIV co-infection and the presence of other TB foci.
Department of Infectious Diseases, Amiens University Hospital, Amiens, France. lanoix.jean-philippe@chu-amiens.fr
J-P
JP
Lanoix
T
T
Guimard
N
N
Ettahar
A
A
Grannec
C
C
Flateau
C
C
Chapuzet
H
H
Bentayeb
P
P
Tattevin
J-L
JL
Schmit
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014376:Tuberculosis / Q000453:epidemiology / Q000503:physiopathology; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*; D015431:Weight Loss; D055815:Young Adult
D000995:Antitubercular Agents