Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential.
β-Glucans are naturally occurring carbohydrates found in plants, fungi and some bacterial species, and currently are well-established and powerful immunomodulators with beneficial properties in cancer therapy. Recent studies suggested that some additional bioactive molecules have synergistic effects when combined with glucan. In the current study, we evaluated the anticancer properties of glucan, resveratrol, vitamin C combination. We found that compared to the individual components, the combination was the strongest activator of phagocytosis and antibody formation. Using two different models of cancer treatment, our results demonstrated that the combination strongly suppressed the growth of breast and lung tumors, most likely due to the stimulation of apoptosis.
Department of Pathology, University of Louisville, Louisville, KY 40218, USA. vaclav.vetvicka@louisville.edu
Vaclav
V
Vetvicka
Jana
J
Vetvickova
D000818:Animals; D000917:Antibody Formation; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006098:Granulocytes / Q000187:drug effects; D007155:Immunologic Factors / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010587:Phagocytosis; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D047071:beta-Glucans / Q000627:therapeutic use*
D000975:Antioxidants; D007155:Immunologic Factors; D013267:Stilbenes; D047071:beta-Glucans; D010047:Ovalbumin; D001205:Ascorbic Acid; D000077185:Resveratrol