Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults.
The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and under 3-minute HV was examined in 125 healthy subjects divided into younger (age range 28-50) and older (age range 51-82) cohorts and stratified by ApoE genotype. The younger ApoE-epsilon4 carriers had excessive EEG reactivity to HV characterized by the manifestation of high-voltage delta, theta activity and sharp waves, and larger HV-induced changes in EEG relative powers than in the younger ApoE-epsilon4 noncarriers. EEG reactivity to HV decreased with aging, and in the ApoE-epsilon4 carriers the decrease was more pronounced than in the ApoE-epsilon4 noncarriers. The older ApoE-epsilon4 carriers had smaller HV-induced changes in EEG relative powers than the older ApoE-epsilon4 noncarriers. A marked decline of EEG reactivity to HV in the older ApoE-epsilon4 carriers suggests the possible impact of vascular factors on the pathogenesis of ApoE-induced Alzheimer disease.
Research Center of Neurology RAMS, Moscow, Russia. ponomare@yandex.ru
Natalya V
NV
Ponomareva
Andrey Y
AY
Goltsov
Svetlana S
SS
Kunijeva
Nadejda S
NS
Scheglova
Daria D
DD
Malina
Andrey A
AA
Mitrofanov
Tatiana I
TI
Boikova
Evgeny I
EI
Rogaev
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001921:Brain / Q000502:physiology*; D058256:Brain Waves / Q000235:genetics*; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D005838:Genotype; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000235:genetics*
D053327:Apolipoprotein E4