Actin in hair cells and hearing loss.
Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system.
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA.
Meghan C
MC
Drummond
Inna A
IA
Belyantseva
Karen H
KH
Friderici
Thomas B
TB
Friedman
D000199:Actins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D020022:Genetic Predisposition to Disease; D006198:Hair Cells, Auditory / Q000378:metabolism*; D034381:Hearing Loss / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D040941:Heredity; D006801:Humans; D040542:Mechanotransduction, Cellular; D008958:Models, Molecular; D010641:Phenotype; D011487:Protein Conformation; D059547:Stereocilia / Q000378:metabolism; D013329:Structure-Activity Relationship
D000199:Actins