Applicability of hybrid linear ion trap-high resolution mass spectrometry and quadrupole-linear ion trap-mass spectrometry for mycotoxin analysis in baby food.
Recent developments in mass spectrometers have created a paradoxical situation; different mass spectrometers are available, each of them with their specific strengths and drawbacks. Hybrid instruments try to unify several advantages in one instrument. In this study two of wide-used hybrid instruments were compared: hybrid quadrupole-linear ion trap-mass spectrometry (QTRAP®) and the hybrid linear ion trap-high resolution mass spectrometry (LTQ-Orbitrap®). Both instruments were applied to detect the presence of 18 selected mycotoxins in baby food. Analytical parameters were validated according to 2002/657/CE. Limits of quantification (LOQs) obtained by QTRAP® instrument ranged from 0.45 to 45 μg kg⁻¹ while lower limits of quantification (LLOQs) values were obtained by LTQ-Orbitrap®: 7-70 μg kg⁻¹. The correlation coefficients (r) in both cases were upper than 0.989. These values highlighted that both instruments were complementary for the analysis of mycotoxin in baby food; while QTRAP® reached best sensitivity and selectivity, LTQ-Orbitrap® allowed the identification of non-target and unknowns compounds.
Departament de Medicina Preventiva i Salut Pública, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés 46100 Burjassot, Spain. josep.rubert@uv.es
Josep
J
Rubert
Kevin J
KJ
James
Jordi
J
Mañes
Carla
C
Soler
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis*; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000295:instrumentation*; D009183:Mycotoxins / Q000032:analysis*
D009183:Mycotoxins