Inflammation and thrombosis: new insights.
Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.
Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.
Patrick A
PA
Lester
Jose A
JA
Diaz
Katherine A
KA
Shuster
Peter K
PK
Henke
Thomas W
TW
Wakefield
Daniel D
DD
Myers
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000097:blood*; D013927:Thrombosis / Q000473:pathology*