Structures of two new phenolic glycosides, kaempferiaosides A and B, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora.
Two new phenolic glycosides, kaempferiaosides A and B were isolated from the rhizomes of Kaempferia parviflora (Zingiberaceae) together with 24 known compounds. Their structures including absolute stereochemistry were elucidated on the basis of chemical and spectroscopic evidence. Among the isolates, 5,3'-dihydroxy-3,7,4'-trimethoxyflavone showed higher activity than silybin, a commercial hepatoprotective agent.
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577- 8502, Japan.
Saowanee
S
Chaipech
Toshio
T
Morikawa
Kiyofumi
K
Ninomiya
Masayuki
M
Yoshikawa
Yutana
Y
Pongpiriyadacha
Takao
T
Hayakawa
Osamu
O
Muraoka
D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D030521:Zingiberaceae / Q000737:chemistry*
D006027:Glycosides; D010636:Phenols; D020011:Protective Agents; C571690:kaempferiaoside A; C571691:kaempferiaoside B