Homeopathic medicines substantially reduce the need for clotting factor concentrates in haemophilia patients: results of a blinded placebo controlled cross over trial.
BACKGROUND
Modern management of haemophilia patients is expensive: 90% of expenditure is on clotting factor concentrates. Any intervention which reduces the need for clotting factor concentrates in these patients without compromising the quality of life is of interest.


OBJECTIVE
To investigate the effectiveness of individualised homeopathic medicines in reducing the requirement of factor concentrates in haemophilia patients.


METHODS
In a single blind placebo controlled cross over trial 28 consecutive persons with haemophilia (PWH) with severe (24) or moderately severe (4) disease received standard management with placebo homeopathy for 1 year and active homeopathic treatment in the subsequent year with the same conventional management. There was no wash out period. They received standard managements for any acute emergency during the study period. Development of inhibitor during the study period was a withdrawal criterion. Sample size for the trial was calculated as 24 PWH. Transfusion requirements, bleeding scores, pain scores were evaluated blind by independent experts. Homeopathic medicines were selected by experienced homeopathic physicians depending on clinical condition of the patient. Chi-squared and paired t tests were used in statistical analysis.


RESULTS
28 patients were recruited. Homeopathic medicines improved frequency of bleeding, extent of bleeding, blood products consumed and pain scores (P<0.0001). There was also significant improvement in well being. Plasma levels of clotting factors did not change. No patients developed inhibitors during the study there were no dropouts.


CONCLUSIONS
Individualised homeopathic medicines may have an important supportive role in the management of PWH, where blood products and factor concentrates are not easily available. Larger, perhaps multicentric trials are warranted.
Haemophilia Care Centre:Nashik Chapter, Niramay Nursing Home, Adwait Colony, Canada Corner, Sharanpur Road, Nashik 422-005, India.
Tapas
T
Kundu
Afroz
A
Shaikh
Afzal
A
Kutty
Aparna
A
Nalvade
Sudhir
S
Kulkarni
Ranjan
R
Kulkarni
Kanjaksha
K
Ghosh
D000293:Adolescent; D001779:Blood Coagulation Factors / Q000187:drug effects; D002648:Child; D018592:Cross-Over Studies; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006705:Homeopathy; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage*; D010147:Pain Measurement; D012720:Severity of Illness Index; D016037:Single-Blind Method; D016896:Treatment Outcome
D001779:Blood Coagulation Factors; D008419:Materia Medica