Sex differences in perihemorrhagic edema evolution after spontaneous intracerebral hemorrhage.
OBJECTIVE
Clinical data on sex differences in perihemorrhagic edema (PHE) after intracerebral hemorrhage (ICH) are lacking.


METHODS
Patients with spontaneous supratentorial ICH who had received standard conservative treatment were identified retrospectively. PHE development was assessed over a 14-day period on follow-up CT scans (days 1, 2-4, 5-7, 8-11, and 12-14). ICH and PHE volumes were assessed semiautomatically and compared between men and women.


RESULTS
A total of 387 patients (233 men) were included. Starting at days 2-4, women showed lower PHE values (P < 0.05; days 2-4, 8-11) or a trend toward significance (P ≤ 0.1; days 5-7, 12-14).


CONCLUSIONS
Female sex may predict lower PHE volumes.
Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. ingrid.wagner@uk-erlangen.de
I
I
Wagner
B
B
Volbers
S
S
Kloska
A
A
Doerfler
S
S
Schwab
D
D
Staykov
D000368:Aged; D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed