The geographic origin of Helicobacter pylori influences the association of the homB gene with gastric cancer.
We found that South Korean Helicobacter pylori isolates predominantly carry homB at locus B and that there is no association between the homB allele and the cagA allele or the development of gastric cancer within this population. Uniquely, several East Asian strains carried multiple copies of the hom genes.
Department of Oral Biology, Oral Science Research Center, BK21 Project, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University College of Dentistry,Seoul, South Korea.
Jieun
J
Kang
Kathleen R
KR
Jones
Sungil
S
Jang
Cara H
CH
Olsen
Yun-Jung
YJ
Yoo
D Scott
DS
Merrell
Jeong-Heon
JH
Cha
D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000235:genetics; D001208:Asia; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C546056:HomB protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori