PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.
Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey. suleyasar@yahoo.com
N Sule Yaşar
NS
Bilge
Timuçin
T
Kaşifoğlu
Cengiz
C
Korkmaz
D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006042:Goiter / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*; D028761:Withholding Treatment; D055815:Young Adult
D013956:Antithyroid Agents; D007166:Immunosuppressive Agents; D011441:Propylthiouracil