[Summary of the multidisciplinary guideline 'Varicella'].
The multidisciplinary guideline 'Varicella' provides guidelines for diagnosis, therapy, and prevention of chickenpox. At the first pregnancy check, patients should be questioned about previous chickenpox; in case of a negative or doubtful history varicella zoster virus (VZV) serology is indicated. VZV antibody determination is also indicated in patients considered for immunosuppressive therapy and for healthcare workers with a negative VZV history who are in contact with immunocompromised patients. Administration of VZV immunoglobulin within 96 hours following VZV contact can mitigate the infection in pregnant women and patients with T-cell deficiency. VZV immunoglobulin treatment should be considered for newborn infants of mothers who developed chickenpox in the period from five days before to two days after delivery. Antivirals can reduce the severity of infection and are safe during pregnancy. Varicella vaccine protects against chickenpox, but is contraindicated in immunocompromised patients and pregnant women.
Nederlandse Vereniging voor Medische Microbiologie, Utrecht, the Netherlands. p.rothbarth@rijnland.nl
Ph H Flip
PH
Rothbarth
Nico G
NG
Hartwig
Wim
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Opstelten
D000914:Antibodies, Viral / Q000097:blood*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002644:Chickenpox / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D019433:Chickenpox Vaccine / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D008297:Male; D009426:Netherlands; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*
D000914:Antibodies, Viral; D000998:Antiviral Agents; D019433:Chickenpox Vaccine