Matrix metalloproteinase 9 mRNA: an early prognostic marker for patients with acute stroke.
OBJECTIVE
To investigate matrix metalloproteinase 9 (MMP9) mRNA as a prognostic marker in stroke.


METHODS
MMP9 mRNA concentrations in 126 stroke patients were analyzed using quantitative reverse transcription-polymerase chain reaction.


RESULTS
The normalized MMP9 mRNA concentration was almost 3 times higher in non-survival patients compared to survival patients (P=0.0002); and 1.9-fold higher in patients with post-stroke modified Rankin score (mRS) >2 than patients with mRS≤2 (P<0.05).


CONCLUSIONS
MMP9 mRNA was a predictor of poor outcome and mortality in stroke.
Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Main Clinical Block and Trauma Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR.
Colin A
CA
Graham
Rebecca W Y
RW
Chan
Dexter Y S
DY
Chan
Cangel P Y
CP
Chan
Lawrence K S
LK
Wong
Timothy H
TH
Rainer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D058621:Blood Buffy Coat / Q000378:metabolism; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006474:Hemorrhagic Disorders / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012333:RNA, Messenger / Q000097:blood*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology
D015415:Biomarkers; D012333:RNA, Messenger; D020780:Matrix Metalloproteinase 9