Isolation, structure elucidation, and biological activity of a new alkaloid from Zanthoxylum rhetsa.
Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.
Department of Chemistry, University of Paderborn, Warburger Str. 100, 33098 Paderborn, Germany. k.krohn@uni-paderborn.de
Karsten
K
Krohn
Stephan
S
Cludius-Brandt
Barbara
B
Schulz
Mambatta
M
Sreelekha
Pottachola Mohamed
PM
Shafi
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification*; D032106:Zanthoxylum / Q000737:chemistry*
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011799:Quinazolines; C569884:quinazoline-6-carboxylic acid