A self-powered "sense-act-treat" system that is based on a biofuel cell and controlled by boolean logic.
Bio-logic-al: an autonomous, integrated "sense-act-treat" system that is based on an enzymatic biofuel cell has been developed. The system couples a biocomputing logic-detection method with a drug-release system to provide a logic-activated therapeutic intervention in response to a simulated abnormal physiological state, without the need for an external power source, control electronics, or microelectromechanical actuators.
Department of Nanoengineering, University of California-San Diego, La Jolla, 92093, USA.
Ming
M
Zhou
Nandi
N
Zhou
Filiz
F
Kuralay
Joshua R
JR
Windmiller
Serguey
S
Parkhomovsky
Gabriela
G
Valdés-Ramírez
Evgeny
E
Katz
Joseph
J
Wang
D000007:Abdominal Injuries / Q000188:drug therapy; D000082:Acetaminophen / Q000008:administration & dosage; D000818:Animals; D001674:Bioelectric Energy Sources; D015374:Biosensing Techniques; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004566:Electrodes; D004581:Electronics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011108:Polymers / Q000737:chemistry
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004337:Drug Carriers; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D000082:Acetaminophen; D007770:L-Lactate Dehydrogenase