Facing the noise: addressing the endemic variability in D(LCO) testing.
Single-breath diffusing capacity of the lung for carbon monoxide (D(LCO)) is a common pulmonary function test that measures the ability of the lung to exchange gas across the alveolar-capillary interface. D(LCO) testing is used to narrow the differential diagnosis  of obstructive and restrictive lung disease, to aid in disability and transplant assessment, and to monitor medication toxicity. The variability in the measurement limits the utility of the test. Variability is attributable to differences in equipment, testing conditions, patient factors,  and reference equations. Laboratories can minimize variability by ensuring that equipment meets recommended standards, implementing effective quality control programs, standardizing testing conditions and testing procedures, and accounting for pertinent patient characteristics.
Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. mmccor16@jhmi.edu
Meredith C
MC
McCormack
D002245:Carbon Dioxide / Q000032:analysis*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis; D008173:Lung Diseases, Obstructive / Q000175:diagnosis; D011653:Pulmonary Diffusing Capacity / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D011786:Quality Control; D012016:Reference Values; D015203:Reproducibility of Results
D002245:Carbon Dioxide