Comparison of dual-source 64-slice adenosine stress CT perfusion with stress-gated SPECT-MPI for evaluation of left ventricular function and volumes.
BACKGROUND
Evaluation of left ventricular (LV) volumes and ejection fraction (LVEF) represent important components of pharmacologic stress imaging with either myocardial CT perfusion (CTP) or gated single-photon emission CT (SPECT) myocardial perfusion imaging (SPECT-MPI).


OBJECTIVE
We compared measurements of left ventricular function and volumes obtained with CTP and SPECT-MPI.


METHODS
Forty-seven patients (mean age, 62 ± 11 years; male, n = 39) underwent stress CTP and SPECT-MPI. LVEF (in %), end-systolic volume (ESV; in mL), and end-diastolic volume (EDV; in mL) derived from stress CTP images were compared with SPECT-MPI.


RESULTS
Stress CTP was in good agreement with SPECT-MPI for quantification of LVEF (r = 0.91), EDV (r = 0.75), and ESV (r = 0.83; all P < 0.001). The mean LVEF measured by stress CTP (66% ± 17%) was similar to SPECT-MPI (64% ± 15%). Similar values were also derived for mean EDV (123 ± 30 mL vs 120 ± 34 mL) and ESV (44 ± 28 mL vs 51 ± 34 mL) for CTP and SPECT-MPI, respectively. Good agreement was also shown between both techniques for the assessment of regional wall motion with identical wall motion scores in 95.3% of the segments (κ = 0.79).


CONCLUSIONS
LVEF and LV volume parameters as determined by dual-source 64-slice adenosine stress CTP show a high correlation with values obtained with stress-gated SPECT-MPI.
Cardiac MRI/PET/CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School 165 Cambridge Street, Suite 400, Boston, MA 02114, USA.
Shanmugam
S
Uthamalingam
Gagandeep S
GS
Gurm
Manavjot S
MS
Sidhu
Daniel J
DJ
Verdini
Yongkasem
Y
Vorasettakarnkij
Leif-Christopher
LC
Engel
Ron
R
Blankstein
Wilfred S
WS
Mamuya
Udo
U
Hoffman
Thomas J
TJ
Brady
Ricardo C
RC
Cury
Brian B
BB
Ghoshhajra
D055424:Cardiac-Gated Imaging Techniques / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology*