Tim-3, a negative regulator of anti-tumor immunity.
T cell immunoglobulin-3 (Tim-3) was identified nearly 10 years ago as a negative regulator of IFN-γ-secreting CD4(+) T helper 1 and CD8(+) T cytotoxic 1 cells. Tim-3 is now classed with other inhibitory receptors, such as cytotoxic lymphocyte antigen-4 and programmed death-1 that are commonly referred to as immune checkpoint molecules. Recent studies have highlighted Tim-3 as an important player in the CD8(+) T cell exhaustion that takes place in chronic immune conditions such as chronic viral infection and cancer in both humans and experimental models. In addition to its role in exhausted T cells, recent data suggest that Tim-3 can further influence cancer outcome through its action on myeloid cells and cancer stem cells.
Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. aanderson@rics.bwh.harvard.edu
Ana Carrizosa
AC
Anderson
D000818:Animals; D006801:Humans; D007167:Immunotherapy; D008565:Membrane Proteins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D011991:Receptors, Virus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D008565:Membrane Proteins; D011991:Receptors, Virus