An electroencephalographic investigation of short-term effects of three hypothalamic hormones (TRH, LH/FSH-RH, GH-RIH) in normal subjects.
Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects. TRH was given as a 10 ml infusion of 600 microg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude. LH/FSH-RH was given in a dose of 200 microg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects. GH-RIH was given as a 10 ml infusion of 250 microg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne.
H
H
Ashton
J E
JE
Millman
R
R
Telford
J W
JW
Thompson
T F
TF
Davies
R
R
Hall
D000328:Adult; D003265:Contingent Negative Variation / Q000187:drug effects / Q000502:physiology; D003366:Cosyntropin / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects* / Q000523:psychology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D013004:Somatostatin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D055815:Young Adult
D003366:Cosyntropin; D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D006854:Hydrocortisone