Electrospun fiber template for replica molding of microtopographical neural growth guidance.
A method for replica molding electrospun (ES) fibers on the surface of polydimethylsiloxane (PDMS) is developed for culturing and guiding of cells, instead of ES fibers. With this method, microgrooves and microstructures composed of microgrooves can be obtained. PDMS is integrated into the microfluidic chip as a substrate to successfully pattern and guide neurites on the PDMS surface with microgrooves.
CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China.
Yingyi
Y
Liu
Yi
Y
Sun
Hao
H
Yan
Xiyu
X
Liu
Wei
W
Zhang
Zhuo
Z
Wang
Xingyu
X
Jiang
D000818:Animals; D002478:Cells, Cultured; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D018625:Microscopy, Atomic Force; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D016501:Neurites / Q000502:physiology / Q000648:ultrastructure; D055495:Neurogenesis / Q000502:physiology*; D011108:Polymers / Q000737:chemistry; D051381:Rats
D011108:Polymers