Novel benzanthrone aminoderivatives for membrane studies.
The potential of novel benzanthrone aminoderivatives to trace the changes in physicochemical properties of lipid bilayer has been evaluated. Binding of the dyes to the lipid bilayers composed of zwitterionic phospholipid phosphatidylcholine (PC) and its mixtures with anionic phospholipid cardiolipin (CL) and cholesterol (Chol) was followed by significant quantum yield increase with small blue shift of emission maximum. Analysis of partition coefficients of the dyes under study showed that all aminobenzanthrones possess high lipid-associating ability. The dyes A8 and AM2 proved to be sensitive to the variations in membrane chemical composition responding to the changes in bilayer hydration induced by CL and Chol.
Department of Biological and Medical Physics, VN Karazin Kharkov National University, Kharkov, Ukraine. valtrusova@yahoo.com
Valeriya M
VM
Trusova
Elena
E
Kirilova
Inta
I
Kalnina
Georgiy
G
Kirilov
Olga A
OA
Zhytniakivska
Pavel V
PV
Fedorov
Galyna P
GP
Gorbenko
D000818:Animals; D001551:Benz(a)Anthracenes / Q000138:chemical synthesis / Q000737:chemistry*; D002417:Cattle; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D001551:Benz(a)Anthracenes; D005456:Fluorescent Dyes; D008051:Lipid Bilayers; D010743:Phospholipids; C012768:benzanthrone