Does consumption of two portions of salmon per week enhance the antioxidant defense system in pregnant women?
Salmon is a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, could affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women. The Salmon in Pregnancy Study provided two meals of salmon per week to pregnant women from week 20 of gestation; the control group maintained their habitual diet low in oily fish. Higher selenium and retinol plasma concentrations were observed after dietary salmon supplementation. Besides, a concomitant increase in selenium and glutathione concentration as well as glutathione peroxidase and reductase activities were detected as pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy. Clinical trials identifier NCT00801502.
Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Institute of Nutrition and Food Technology José Mataix, University of Granada, Granada, Spain. erikagr@ugr.es
Cruz E
CE
García-Rodríguez
María D
MD
Mesa
Josune
J
Olza
Maria
M
Vlachava
Lefkothea-Stella
LS
Kremmyda
Norma D
ND
Diaper
Paul S
PS
Noakes
Elizabeth A
EA
Miles
María Carmen
MC
Ramírez-Tortosa
Bjørn
B
Liaset
Livar
L
Frøyland
Adrien
A
Rossary
Marie-Chantal
MC
Farges
Marie-Paule
MP
Vasson
Concepcion M
CM
Aguilera
Johanna
J
Helmersson-Karlqvist
Keith M
KM
Godfrey
Philip C
PC
Calder
Samar
S
Basu
Angel
A
Gil
D000293:Adolescent; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D012474:Salmon; D017747:Seafood; D012643:Selenium / Q000097:blood / Q000378:metabolism; D024505:Tocopherols / Q000097:blood / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D014801:Vitamin A / Q000097:blood / Q000378:metabolism; D055815:Young Adult; D019207:beta Carotene / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D019207:beta Carotene; D014801:Vitamin A; D014451:Ubiquinone; C024989:coenzyme Q10; D005978:Glutathione; D012643:Selenium; D024505:Tocopherols