Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations.
We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.
Pain and Sensory Disorders Research Unit, Pfizer Laboratories, Sandwich, United Kingdom. naa170767@yahoo.co.uk
Nick
N
Andrews
Sinead
S
Harper
Yasmin
Y
Issop
Andrew S C
AS
Rice
D000700:Analgesics / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D059350:Chronic Pain / Q000188:drug therapy / Q000503:physiopathology; D005620:Freund's Adjuvant / Q000633:toxicity; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage; D010147:Pain Measurement / Q000379:methods*; D051381:Rats; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D015203:Reproducibility of Results; D013045:Species Specificity
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D005620:Freund's Adjuvant; D007052:Ibuprofen