Interleukin-23 serum levels in patients affected by peripheral arterial disease.
OBJECTIVE
To clarify whether interleukin (IL)-23 is involved in peripheral arterial disease (PAD).


METHODS
We evaluated IL-23 serum levels, in 29 patients suffering from lower extremity PAD and in 30 healthy subjects.


RESULTS
IL-23 serum levels were higher during the three times (T0, T1 and T2) compared to the control group, although only statistically significant for T0 and T2: T0 (15.83 ± 22.08 vs. 8.08 ± 8.62 pg ml, p=0.026), T1 (16.10 ± 23.71 vs. 8.08 ± 8.62 pg/ml, p=0.101), T2 (15.06 ± 16.72 vs. 8.08 ± 8.62 pg/ml, p=0.005).


CONCLUSIONS
For the first time, our data gives us reason to believe there is an involvement of IL-23 in PAD.
Department of Neurosciences, Psichiatric and Anesthesiological Sciences, University of Messina, Italy.
Antonio
A
David
Salvatore
S
Saitta
Giovanni
G
De Caridi
Filippo
F
Benedetto
Mafalda
M
Massara
Domenica Claudia
DC
Risitano
Francesco Saverio
FS
Venuti
Francesco
F
Spinelli
Sebastiano
S
Gangemi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053760:Interleukin-23 Subunit p19 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood*
C508840:IL23A protein, human; D053760:Interleukin-23 Subunit p19