Hollow poly(MPC-g-PEG-b-PLA) graft copolymer microcapsule as a potential drug carrier.
In this article, an amphiphilic graft copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the hydrophilic backbone, poly(L-lactic acid) (PLA) as the hydrophobic side-chains and polyethylene glycol (PEG) as the spacer was synthesized. Transmission electron microscopy revealed that the graft copolymer could self-assemble into hollow microcapsules when dialyzed in aqueous solution and particle sizes ranged from 200 to 300 nm, while the graft copolymer formed core-shell microspheres with the absence of PEG spacer. X-ray photoelectron microscope showed that MPC polymers were located at the surface of the microcapsules. The amounts of adsorbed bovine serum albumin and Fg on the microcapsules were significantly decreased than that on the conventional PLA particles (74% and 60%, respectively), well indicating the anti-adhesive property of the microcapsules. Paclitaxel was chosen as a prototype anticancer drug for the encapsulation and release studies, the results showed that the drug encapsulation efficiency was 89.3 ± 1.2% and the microcapsules exhibited controlled release behaviour.
School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
Chaoyong
C
Liu
Lixia
L
Long
Zhi
Z
Li
Bin
B
He
Liuheng
L
Wang
Jiapeng
J
Wang
Xubo
X
Yuan
Jing
J
Sheng
D000327:Adsorption; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D002214:Capsules / Q000737:chemistry*; D002417:Cattle; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004577:Electron Probe Microanalysis / Q000379:methods; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008689:Methacrylates; D017239:Paclitaxel / Q000008:administration & dosage; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids; D012710:Serum Albumin, Bovine / Q000737:chemistry
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D002214:Capsules; D004337:Drug Carriers; D008689:Methacrylates; D011091:Polyesters; D011108:Polymers; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); D017239:Paclitaxel