G-quadruplexes and metal ions.
Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.
The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Nancy H
NH
Campbell
Stephen
S
Neidle
D054856:G-Quadruplexes; D007477:Ions / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D016615:Telomere / Q000737:chemistry / Q000235:genetics
D007477:Ions; D008670:Metals