Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency.
OBJECTIVE
Advanced oxidation protein products (AOPPs) represent dityrosine-containing cross-linked protein modifications formed mainly via myeloperoxidase reaction, supposed to accelerate the uremia-associated atherogenesis and renal fibrosis. DESIGN, SUBJECTS, AND MAIN OUTCOME MEASURES: In a cross-sectional study, we investigated the accumulation of AOPPs and advanced glycation end product (AGE)-specific fluorescence corrected for albumin in children and adolescents with chronic renal failure (CRF, n = 42), end-stage renal disease (ESRD, n = 12), kidney transplanted patients (Tx, n = 16), and age-matched healthy controls (n = 38).


RESULTS
AOPP levels were 2.4-fold higher in the CRF and ESRD patients, and 1.6-fold higher in the transplanted subjects when compared with the controls (P < .001). In comparison with healthy controls, AGE levels rose 2-fold in the CRF, 7-fold in the ESRD, and 5-fold in the kidney transplanted children and adolescents, (P < .001). Patients with cardiovascular affliction presented with higher AGE levels than those without diagnosed cardiovascular disease (P < .02). In patients with stabilized renal function, AOPP and AGE levels did not change significantly during 12 months.


CONCLUSIONS
Pattern of accumulation of AOPP and AGE in children and adolescents with chronic renal disease differs. Accelerated rise in AOPP levels in some children and adolescents in predialysis stage of chronic renal insufficiency, inadequate to deterioration of renal function, might require further attention.
Institute of Molecular BioMedicine, Comenius University, Bratislava, Slovakia. kata.sebekova@gmail.com
Katarína
K
Sebeková
Kristína
K
Klenovicsová
Juliana
J
Ferenczová
Juraj
J
Hedvig
L'udmila
L
Podracká
August
A
Heidland
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation; D008297:Male; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000601:surgery; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D017127:Glycation End Products, Advanced; D012709:Serum Albumin