Effects of oral salbutamol and pirbuterol on FEV1, heart rate and blood pressure in asthmatics.
In a double-blind trial the effects on ventilatory function (FEV1), heart rate and blood pressure of oral pirbuterol and oral salbutamol in various single doses were studied in ten patients with chronic asthma. Pirbuterol (15 mg) and salbutamol (4 mg) produced equal peak levels of bronchodilatation. There was no significant difference in the mean rise in heart rates caused by the two drugs, and no other significant side-effects were noted.
Respiratory Diseases Unit, Northern General Hospital Edinburgh EH5 2DQ.
R F
RF
Willey
I W
IW
Grant
S J
SJ
Pocock
D000284:Administration, Oral; D000368:Aged; D000420:Albuterol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004983:Ethanolamines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D001993:Bronchodilator Agents; D004983:Ethanolamines; C009118:pirbuterol; D000420:Albuterol