Osteopontin predicts the behaviour of atypical meningioma.
OBJECTIVE
Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic variability. Osteopontin (OPN) and cortactin play important roles in tumorigenesis, invasion and metastasis of several human cancers. The aim of this study was to evaluate the usefulness of OPN and cortactin immunohistochemistry for distinguishing between benign, atypical and malignant meningioma and predicting their recurrence.


RESULTS
Seventy-five specimens (48 benign, 17 atypical and 10 malignant meningiomas) were investigated immunohistochemically. The mean immunohistochemical scoreimmunohistochemical score ± SE of the mean of both OPN and cortactin were significantly higher in grade II or grade III meningiomas than in grade I meningioma. Discriminant analysis of immunohistochemical OPN expression showed correct classification of 97.7% of WHO grade I meningiomas and 88.2% of WHO grade II meningiomas (95.4% accuracy). However, the same analysis of cortactin expression showed correct classification of 95.8% of WHO grade I meningiomas and only 23.5% of WHO grade II meningiomas (76.9% accuracy). A cut-off for predicting grades I and II meningioma recurrence was determined for OPN (3.0) but not for cortactin. Finally, logistic regression identified both this cut-off (P < 0.05) and WHO grade (P < 0.05) as independent risk factors for recurrence.


CONCLUSIONS
OPN expression is a valuable marker for diagnosis of atypical meningioma and prediction of grades I and II meningioma recurrence.
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chih-Kung
CK
Lin
Wen-Chiuan
WC
Tsai
Yu-Chun
YC
Lin
Dueng-Yuan
DY
Hueng
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D051356:Cortactin / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008579:Meningioma / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014944:World Health Organization
D014408:Biomarkers, Tumor; D051356:Cortactin; D053495:Osteopontin