Synthesis of cis- and trans-3-aminocyclohexanols by reduction of β-enaminoketones.
We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols.
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca, Mor., CP 62209, Mexico.
Iris Montoya
IM
Balbás
Blanca Eda Domínguez
BE
Mendoza
Mario
M
Fernández-Zertuche
Mario
M
Ordoñez
Irma
I
Linzaga-Elizalde
D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D003511:Cyclohexanols; D007659:Ketones