Hepatoprotective effect of Filipendula hexapetala Gilib. (Rosaceae) in carbon tetrachloride-induced hepatotoxicity in rats.
The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase.
Institute of Biochemistry, School of Medicine, University of Novi Sad, Novi Sad, Serbia. cebovictatjana@gmail.com
Tatjana
T
Cebović
Zoran
Z
Maksimović
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D031984:Filipendula / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000009:adverse effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D010936:Plant Extracts; D006861:Hydrogen Peroxide; D002251:Carbon Tetrachloride; D002374:Catalase; D009195:Peroxidase; D005978:Glutathione