Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.
B cells exhibit a range of functional responses following TLR engagement including immunoglobulin and cytokine production, proliferation, antigen presentation and migration. However, B cell intrinsic TLR responses appear to be precisely programmed based upon the developmental stage of the cell. B cell subpopulations classified as innate immune cells including marginal zone and B-1 B cells exhibit robust responses to TLR stimulation. In contrast, activation of other B cell subsets is constrained via a variety of developmentally regulated events. In this review we provide an overview of TLR responses in murine and human B cells and specifically highlight patterns of TLR expression and developmentally regulated functional responses.
Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, D-30625 Germany. meyer-bahlburg.almut@mh-hannover.de
Almut
A
Meyer-Bahlburg
David J
DJ
Rawlings
D000818:Animals; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D002454:Cell Differentiation; D002470:Cell Survival; D006801:Humans; D016131:Lymphocyte Subsets; D051379:Mice; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*
D051193:Toll-Like Receptors