A new route to indazolone via amidation reaction of o-carboxyazobenzene.
One new route for the synthesis of amino-substituted indazol-3,5-dione via the amidation reaction of o-carboxyazobenzenes is reported. Optimization which includes effects of the solvents, molar ratio of starting materials, and dehydrating agents on this reaction has been studied. A possible reaction mechanism has been proposed on the basis of the product's structure, and the steric hindrance could be the main reason for low yield.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Chengjie
C
Li
Tianyi
T
Zhang
Zhe
Z
Zeng
Xiujun
X
Liu
Yunfeng
Y
Zhao
Bao
B
Zhang
Yaqing
Y
Feng
D000586:Amination; D001391:Azo Compounds / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure
D001391:Azo Compounds; D007191:Indazoles; D001554:Benzene