New glycosides from Dracocephalum tanguticum maxim.
Four new glycosides, luteolin-7-methoxy-3'-O-(3″-O-acetyl)-β-D-gluco pyranuronic acid-6″-methyl ester (1), benzyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (2), 2-methoxy-4-(2-propen-1-yl)penyl-6-acetate-β-D-glucopyranoside (3), and 2-methoxy-4-(2-propen-1-yl)penyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (4), along with benzyl-β-D-glucopyranoside (5), 2-methoxy-4-(2-propen-1-yl)penyl-β-D-glucopyranoside (6), and pectolarigenin (7), were isolated from the whole plant of Dracocephalum tanguticum Maxim. The structures of 1-4 were elucidated by detailed spectroscopic analyses, including HR-ESI-MS and 2D NMR spectroscopic data. The inhibitory effects against nitric oxide production in LPS-stimulated RAW264.7 cells of all seven compounds were also evaluated.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Qi
Q
Zeng
Ruijie
R
Chang
Jiangjiang
J
Qin
Xiangrong
X
Cheng
Weidong
W
Zhang
Huizi
H
Jin
D000818:Animals; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D009569:Nitric Oxide