Neurofunctional assessment in a stroke patient with musical hallucinations.
We reported a case of an elderly female patient affected by musical hallucinations (MHs) as the unique symptom of a right temporal ischemic stroke. A functional magnetic resonance imaging examination was performed in the patient and in five age- and sex-matched normal controls (NC) to detect the complex neural substrate subserving MHs in such a context. Although an activation pattern involving the primary auditory cortex and the temporal associative areas bilaterally was found in the patient and NC, a significant increased activation mostly located in right temporal cortex (in the ischemic area), was observed in the patient. Further functional neuroimaging studies should be performed to detect the complex neural pathways underlying MHs and to find out differences between these hallucinations and real music perception.
IRCCS Centro Neurolesi ‘Bonino-Pulejo’, Messina, Italy.
Rocco Salvatore
RS
Calabrò
Annalisa
A
Baglieri
Edoardo
E
Ferlazzo
Smeralda
S
Passari
Silvia
S
Marino
Placido
P
Bramanti
D000369:Aged, 80 and over; D001306:Auditory Pathways / Q000473:pathology / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology; D020520:Brain Infarction / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D059907:Functional Neuroimaging; D006212:Hallucinations / Q000150:complications* / Q000473:pathology / Q000523:psychology; D006801:Humans; D016555:Matched-Pair Analysis; D009146:Music / Q000523:psychology*; D009483:Neuropsychological Tests; D012016:Reference Values; D020521:Stroke / Q000150:complications / Q000473:pathology / Q000523:psychology*; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology