Emulsion droplet sizing using low-field NMR with chemical shift resolution and the block gradient pulse method.
Pulsed Field Gradient (PFG) measurements are commonly used to determine emulsion droplet size distributions based on restricted self-diffusion within the emulsion droplets. Such measurement capability is readily available on commercial NMR bench-top apparatus. A significant limitation is the requirement to selectively detect signal from the liquid phase within the emulsion droplets; this is currently achieved using either relaxation or self-diffusion contrast. Here we demonstrate the use of a 1.1 T bench-top NMR magnet, which when coupled with an rf micro-coil, is able to provide sufficient chemical shift resolution such that unambiguous signal selection is achieved from the dispersed droplet phase. We also improve the accuracy of the numerical inversion process required to produce the emulsion droplet size distribution, by employing the Block Gradient Pulse (bgp) method, which partially relaxes the assumptions of a Gaussian phase distribution or infinitely short gradient pulse application inherent in current application. The techniques are successfully applied to size 3 different emulsions.
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB23RA, UK.
I A
IA
Lingwood
T C
TC
Chandrasekera
J
J
Kolz
E O
EO
Fridjonsson
M L
ML
Johns
D000465:Algorithms; D004655:Emulsions / Q000032:analysis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010316:Particle Size; D012815:Signal Processing, Computer-Assisted
D004655:Emulsions