Biological properties of new viologen-phosphorus dendrimers.
Some biological properties of eight dendrimers incorporating both phosphorus linkages and viologen units within their cascade structure or at the periphery were investigated for the first time. In particular cytotoxicity, hemotoxicity, and antimicrobial and antifungal activity of these new macromolecules were examined. Even if for example all these species exhibited good antimicrobial properties, it was demonstrated that their behavior strongly depends on several parameters as their size and molecular weight, the number of viologen units and the nature of the terminal groups.
Department of General Biophysics, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland.
Karol
K
Ciepluch
Nadia
N
Katir
Abdelkrim
A
El Kadib
Aleksandra
A
Felczak
Katarzyna
K
Zawadzka
Monika
M
Weber
Barbara
B
Klajnert
Katarzyna
K
Lisowska
Anne-Marie
AM
Caminade
Mostapha
M
Bousmina
Maria
M
Bryszewska
Jean Pierre
JP
Majoral
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D050091:Dendrimers / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010758:Phosphorus / Q000737:chemistry*; D014755:Viologens / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D050091:Dendrimers; D014755:Viologens; D010758:Phosphorus