Hemostatic multilayer coatings.
Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Anita
A
Shukla
Jean C
JC
Fang
Sravanthi
S
Puranam
Flemming R
FR
Jensen
Paula T
PT
Hammond
D000818:Animals; D005780:Gelatin / Q000737:chemistry; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000737:chemistry* / Q000494:pharmacology; D006860:Hydrogen Bonding; D059808:Polyphenols / Q000737:chemistry; D055672:Static Electricity; D013552:Swine; D013634:Tannins / Q000737:chemistry; D013917:Thrombin / Q000737:chemistry; D014867:Water / Q000737:chemistry
D006490:Hemostatics; D059808:Polyphenols; D013634:Tannins; D014867:Water; D005780:Gelatin; D013917:Thrombin