Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis.
BACKGROUND
We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years. We previously described the determinants related to a risk of cardiovascular changes determined in a Japanese population participating in the Niigata Study, which is an ongoing epidemiological investigation of the prevention of cardiovascular diseases.


METHODS
We selected 394 individuals (169 males and 225 females) who underwent a second carotid artery ultrasonographic examination in 2001 - 2002 for the present study. The susceptibility of LDL to oxidation was determined as the photometric absorbance and electrophoretic mobility of samples that had been collected in 1996 - 1997. The measurements were compared with ultrasonographic findings obtained in 2001 - 2002.


RESULTS
The multivariate-adjusted model showed that age (odds ratio (OR), 1.034; 95% confidence interval (95%CI), 1.010 - 1.059), HbA1c (OR, 1.477; 95%CI, 0.980 - 2.225), and photometric O/N (OR, 2.012; 95%CI, 1.000 - 4.051) were significant variables that could independently predict the risk of new carotid artery atherosclerosis.


CONCLUSIONS
The susceptibility of LDL to oxidation was a significant parameter that could predict new carotid artery atherosclerosis over a 5-year period, and higher susceptibility was associated with a higher incidence of new carotid artery atherosclerosis.
Division of Clinical Preventive Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1 Asahi-machi, Chuou-ku, Niigata City 951-8510, Japan.
Toshinari
T
Aoki
Tsueko
T
Abe
Eiji
E
Yamada
Takayuki
T
Matsuto
Masahiko
M
Okada
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053299:Apolipoprotein B-100 / Q000097:blood; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010084:Oxidation-Reduction; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D014463:Ultrasonography; D055815:Young Adult
D053299:Apolipoprotein B-100; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein