Roles of Apicomplexan protein kinases at each life cycle stage.
Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. akkato@mail.ecc.u-tokyo.ac.jp
Kentaro
K
Kato
Tatsuki
T
Sugi
Tatsuya
T
Iwanaga
D000818:Animals; D016782:Apicomplexa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D008018:Life Cycle Stages; D010961:Plasmodium / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D014122:Toxoplasma / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development
D047428:Protein Kinase Inhibitors; D015800:Protozoan Proteins; D011494:Protein Kinases