A mouse model of CMV transmission following kidney transplantation.
Reactivation of latent CMV in transplant recipients remains a significant infectious complication of transplantation. Investigation of the cellular and molecular mechanisms by which reactivation occurs has been hampered by the lack of appropriate animal models. Here, we show that transplantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /Szj mice results in reactivation of latent virus in the kidney, resulting in a disseminated primary infection of the recipient. This model will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of spontaneous reactivation, and in testing new therapies for treatment and prevention of CMV reactivation and disease.
Comprehensive Transplant Center, Department of Surgery, Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Z
Z
Li
X
X
Wang
S
S
Yan
Z
Z
Zhang
C
C
Jie
N
N
Sustento-Reodica
M
M
Hummel
M
M
Abecassis
D000818:Animals; D003586:Cytomegalovirus Infections / Q000635:transmission* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D004195:Disease Models, Animal; D053631:Interleukin Receptor Common gamma Subunit / Q000502:physiology; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D018146:Muromegalovirus / Q000502:physiology*; D016133:Polymerase Chain Reaction; D014184:Transplantation, Homologous; D014775:Virus Activation; D017735:Virus Latency
D004279:DNA, Viral; D053631:Interleukin Receptor Common gamma Subunit