Erythrocyte as a link between basic and clinical research.
We review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate.
University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal. carlotasaldanha@fm.ul.pt
C
C
Saldanha
J P Lopes
JP
de Almeida
D002318:Cardiovascular Diseases / Q000097:blood; D003430:Cross-Sectional Studies; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000494:pharmacology; D005901:Glaucoma / Q000097:blood; D006405:Hematology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D046110:Hypertension, Pregnancy-Induced / Q000097:blood; D007674:Kidney Diseases / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D015337:Multicenter Studies as Topic; D009569:Nitric Oxide / Q000097:blood; D011247:Pregnancy; D012106:Research
D009569:Nitric Oxide; D005340:Fibrinogen