Relationship between NF-κB expression and malignancy of canine mammary gland tumor tissues.
In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Lobna
L
Mkaouar
Yoshifumi
Y
Endo
He Xi
HX
Jun
Soo-Jung
SJ
Lee
Tassanee
T
Jaroensong
Manabu
M
Mochizuki
Kazuyuki
K
Uchida
Hiroyuki
H
Nakayama
Nobuo
N
Sasaki
Takayuki
T
Nakagawa
D000818:Animals; D019938:Cyclin D1 / Q000378:metabolism; D004283:Dog Diseases / Q000175:diagnosis / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000378:metabolism*; D008940:Mitotic Index / Q000662:veterinary; D016328:NF-kappa B / Q000378:metabolism*; D011379:Prognosis; D018709:Statistics, Nonparametric
D016328:NF-kappa B; D019938:Cyclin D1