The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver.
The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.
Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
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S
Westin
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Tollet
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Ström
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Mode
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JA
Gustafsson
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D013006:Growth Hormone / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011986:Receptors, Somatotropin / Q000378:metabolism; D020218:Response Elements; D012727:Sex Characteristics; D015398:Signal Transduction; D013250:Steroid Hydroxylases / Q000235:genetics / Q000378:metabolism
D011986:Receptors, Somatotropin; D013006:Growth Hormone; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases