Sarcoidosis manifesting as cardiac sarcoidosis and massive splenomegaly.
Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. We report an unusual case of sarcoidosis in a woman presenting with cardiac sarcoidosis and massive splenomegaly with a familial history of cardiac sarcoidosis. Cardiac sarcoidosis was diagnosed based on electrocardiogram, echocardiogram, 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG-PET) and skin histological findings. We performed splenectomy to rule out malignant lymphoma, and histological findings confirmed sarcoidosis. After splenectomy, we initiated prednisolone therapy. After 20 months of diagnosis, she was symptom free. Echocardiography and 18F-FDG-PET may be a key diagnostic tool and prednisolone therapy may be safe, effective, and feasible for cardiac sarcoidosis.
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan. sayakawano23@yahoo.co.jp
Sayaka
S
Kawano
Johji
J
Kato
Noriaki
N
Kawano
Yuki
Y
Yoshimura
Hiroyuki
H
Masuyama
Takashi
T
Fukunaga
Yoshiya
Y
Shimao
Kenroh
K
Mihara
Akira
A
Ueda
Kiyokazu
K
Toyoda
Takuroh
T
Imamura
Kazuo
K
Kitamura
D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013163:Splenomegaly / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18