Endothelio-hematopoietic relationship: getting closer to the beginnings.
The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in vitro differentiation studies. Teixeira and colleagues describe a novel enhancer that drives specific eGFP expression in blood islands of the electroporated chick embryo, thereby presenting a tool potentially suitable for analysis of hemangioblast differentiation and development of blood islands.
Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh EH16 4UU, Scotland, UK.
Sabrina
S
Gordon-Keylock
Alexander
A
Medvinsky
D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D018274:Electroporation; D042783:Endothelial Cells / Q000166:cytology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*