Preparation and comparative release characteristics of three anthocyanin encapsulation systems.
Bilberries (Vaccinium myrtillus L.) and their major polyphenolic constituents, anthocyanins, have preventive activities inter alia against colon cancer and inflammatory bowel diseases. However, anthocyanins are sensitive to environmental conditions; thus their bioavailability in the gastrointestinal tract is an important determinant of their in vivo activity. In the study reported here, the potential benefits of encapsulating an anthocyanin rich bilberry extract (BE) on anthocyanin stability were investigated. Nonencapsulated BE and three different BE loaded microcapsule systems were incubated in simulated gastric fluid (SGF) and fed state simulated intestinal fluid (FeSSIF). After exposure to these media, released anthocyanins were identified and quantified by HPLC with UV/Vis detection. Although a rapid release of anthocyanins was observed within the first 20 min, encapsulation of anthocyanins doubled the amount of available anthocyanins after 150 min of incubation. These results illustrate the ability of encapsulation to inhibit early degradation of anthocyanins in the intestinal system.
Department of Pharmaceutics and Biopharmaceutics, Pharmaceutical Technology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.
Johannes
J
Oidtmann
Markus
M
Schantz
Karsten
K
Mäder
Matthias
M
Baum
Sonja
S
Berg
Michael
M
Betz
Ulrich
U
Kulozik
Sabine
S
Leick
Heinz
H
Rehage
Karin
K
Schwarz
Elke
E
Richling
D000872:Anthocyanins / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D007700:Kinetics; D008954:Models, Biological; D010936:Plant Extracts; D029800:Vaccinium myrtillus / Q000737:chemistry*
D000872:Anthocyanins; D010936:Plant Extracts; C073305:Vaccinium myrtillus extract