Bifunctional bacterial magnetic nanoparticles for tumor targeting.
Bifunctional bacterial magnetic nanoparticles (BBMPs), which present both magnetic drug targeting and tumor bio-targeting properties, have been developed by chemically coupling both doxorubicin and a galactosyl ligand on to the membrane surface of the bacterial magnetic nanoparticles (BMPs). The BBMP product has a high drug load ratio and magnetic respondence, and exhibits a narrow size distribution and is sensitive to pH to enable drug release. In comparison to doxorubicin-coupled BMPs, without modification with a galactosyl ligand, BBMPs present a higher uptake by the target asialoglycoprotein receptor (ASGP-R) expressed by HepG2 cells and display stronger cytotoxicity.
Key Laboratory of Mesoscopic Chemistry of MOE and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China. linguo@nju.edu.cn
Lin
L
Guo
Ji
J
Huang
Li-Min
LM
Zheng
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D037263:Asialoglycoprotein Receptor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D036103:Nanotechnology
D000970:Antineoplastic Agents; D037263:Asialoglycoprotein Receptor; D058185:Magnetite Nanoparticles; D004317:Doxorubicin