[Cerebrovascular effects of GABA conjugate with arachidonic acid under conditions of separate and combined vascular pathology of brain and heart].
Experiments on rats showed that, under conditions of global transient ischemia, a conjugate of GABA with arachidonic acid enhances the local cerebral blood flow due to a decrease in the vascular tone. In intact rats, the examined neurolipin did not show unidirectional changes in the cerebral perfusion. Under conditions of experimental myocardial infarction and combined vascular pathology of brain and heart, the GABA conjugate with arachidonic acid increased the blood flow in the parietal region of brain cortex in most experiments, while decreasing the level of blood pressure.
A V
AV
Gnezdilova
T S
TS
Gan'shina
D V
DV
Maslennikov
V V
VV
Bezuglov
N M
NM
Gretskaia
R S
RS
Mirzoian
D000818:Animals; D016718:Arachidonic Acid / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D018682:GABA Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
D018682:GABA Agents; D014665:Vasodilator Agents; D016718:Arachidonic Acid; D005680:gamma-Aminobutyric Acid