Role of a neural cell adhesion molecule found in cerebrospinal fluid as a potential biomarker for epilepsy.
The neural cell adhesion molecule (NCAM-1) plays an important role in cell adhesion and synaptic plasticity. We designed this study to evaluate NCAM-1 as a potential biomarker for epilepsy. We performed a quantitative evaluation of the levels of NCAM-1 in cerebrospinal fluid (CSF) and serum and noted differences in patients with epilepsy compared to control subjects. We used sandwich enzyme-linked immunosorbent assays to measure NCAM-1 concentrations in CSF and serum samples of 76 epileptic patients (subdivided into the following subgroups: drug-refractory epilepsy, DRE; first-diagnosis epilepsy, FDE; and drug-effective epilepsy, DEE) and 44 control subjects. Our results show that cerebrospinal fluid-NCAM-1 (CSF-NCAM-1) concentrations and NCAM-1 Indices in the epileptic group were lower than in the control group. Both the CSF-NCAM-1 concentration and the NCAM-1 Indices in the drug-refractory epilepsy group were lower than in the drug-effective epilepsy group. These differences were statistically significant (P < 0.05). However, serum-NCAM-1 levels were not statistically different when comparing the epilepsy group to the control group (P > 0.05). Our results indicate that CSF-NCAM-1 is a potential biomarker for drug-effective epilepsy and drug-refractory epilepsy.
Department of Neurology, The Affiliated Hospital of Guiyang Medical College, 28 Gui Yi Street, Guiyang, 550004 Guizhou Province, China.
Wei
W
Wang
Liang
L
Wang
Jing
J
Luo
Zhiqin
Z
Xi
Xuefeng
X
Wang
Guojun
G
Chen
Lan
L
Chu
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D019002:CD56 Antigen / Q000134:cerebrospinal fluid* / Q000502:physiology; D002648:Child; D004827:Epilepsy / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015415:Biomarkers; D019002:CD56 Antigen; C522918:NCAM1 protein, human