Resting-state oscillatory activity in autism spectrum disorders.
Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, 2nd Floor Wood Bldg., Room 2115, Mail Stop W02-1010, Philadelphia, PA 19104-4399, USA.
Lauren
L
Cornew
Timothy P L
TP
Roberts
Lisa
L
Blaskey
J Christopher
JC
Edgar
D000293:Adolescent; D001683:Biological Clocks / Q000502:physiology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male