Primary breast cancer of the vulva:  a case report.
The occurrence of primary breast cancer of the vulva is extremely rare (24 cases described in the English-language literature). We report a case of a primary breast carcinoma of the vulva. An 82-year-old woman presented with a nodule of the left labia minor, which was excised. The histologic examination revealed the presence of adenocarcinoma of mammary origin, positive for common breast markers and for estrogen and progesterone receptors. The study for orthotopic breast carcinoma was negative, as well as the study for metastatic disease. The diagnosis of primary breast carcinoma was established. Our patient was then submitted to pelvic and inguinal radiotherapy as well as an aromatase inhibitor (letrozole), and she remained completely asymptomatic. Because of the rarity of this condition, guidelines for therapy are unavailable. The management suggested in the literature is that of primary orthotopic breast neoplasm of a similar stage.
Department of Obstetrics, Gynecology and Reproductive Medicine - Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal. Ana.tarucacosta@gmail.com
Ana Teresa Minhoto
AT
Diniz da Costa
Ana Maria
AM
Coelho
Alexandre Valentim
AV
Lourenço
Margarida
M
Bernardino
Ana Luisa
AL
Ribeirinho
Carlos Calhaz
CC
Jorge
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D000077289:Letrozole; D009570:Nitriles / Q000008:administration & dosage; D011878:Radiotherapy; D014230:Triazoles / Q000008:administration & dosage; D014844:Vulva / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole