Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review.
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N. farcinica infection following a liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According to susceptibility test, linezolid was administered with clearly improving the patient's condition. The treatment was stopped for anemia as drug related adverse event, and the therapy lasted for as long as 5 months. At the end of treatment clinical cure was confirmed and anemia reversed after discontinuation of linezolid. We also analyzed the clinical data of previously published reports by literature review, focusing on the efficacy and safety of linezolid treatment for Nocardia infection.
Key Laboratory of Combined Multi-organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery Hospital, Ministry of Public Health, Zhejiang University School of Medicine, Qingchun Road #79, Hangzhou, China. shentian17@yahoo.com.cn
Tian
T
Shen
Lihua
L
Wu
Lei
L
Geng
Zeqing
Z
Wei
Shusen
S
Zheng
D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy*; D023303:Oxazolidinones / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid