Lack of association of mouse mammary tumor virus-like sequences in Iranian breast cancer patients.
OBJECTIVE
The present study aimed to detect mouse mammary tumor virus (MMTV)-like sequences in Iranian breast cancer patients in the city of Shiraz, located in southwest Iran.


METHODS
We searched for two MMTV genetic regions in the peripheral blood leukocytes of 300 women with breast cancer, 300 age-matched healthy control subjects, and 50 breast tumor tissues. Two regions of MMTV, 660 bp and 250 bp, were searched by nested polymerase chain reactions.


RESULTS
None of the above two regions were detected. There were no differences between the control group and the breast cancer group.


CONCLUSIONS
Our findings did not show any association of MMTV-like sequences with breast cancer development in Iranian patients in Shiraz.
Shiraz HIV/Aids Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. motamedm@sums.ac.ir
Mohmmad
M
Motamedifar
Morteza
M
Saki
Abbas
A
Ghaderi
D000818:Animals; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004195:Disease Models, Animal; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007962:Leukocytes / Q000473:pathology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012307:Risk Factors