Have animal models of disease helped or hindered the drug discovery process?
Animal models have played an important role in target validation, screening of compounds for efficacy and optimization of pharmacokinetic properties and toxicological testing. However, new paradigms for drug discovery and development will require a greater emphasis on animal models of mechanism.
OI Pharma Partners Ltd. Weston, Herts, United Kingdom.
Ann Jacqueline
AJ
Hunter
D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D004353:Drug Evaluation, Preclinical; D006801:Humans