Role of carbon monoxide in vascular diseases.
During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non-significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.
Department of Biological Chemistry, Medical Chemistry, and Molecular Biology, University of Catania, Viale Andrea Doria, 6 95125 Catania, Italy.
Ignazio
I
Barbagallo
Giuseppina
G
Marrazzo
Alessandro
A
Frigiola
Agata
A
Zappala
Giovanni
G
Li Volti
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism; D002248:Carbon Monoxide / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D014652:Vascular Diseases / Q000188:drug therapy / Q000378:metabolism*
D020011:Protective Agents; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)