Retrospective analysis on the impact of tuberculosis on patients with systemic lupus erythematosus (SLE).
Up to now, there have been few reports concerning changes in lupus activity and immune indices of tuberculosis in patients with systemic lupus erythematosis (SLE). A retrospective investigation was given to survey the case data of SLE patients companied with tuberculosis that were treated in our hospital from 2001 to 2010 and compared with that of sex- and age-matched patients with single SLE. Changes in autoantibodies, lupus activity, inflammatory indices, positive rates of tuberculin (PPD) test and tuberculosis antibody (TB-Ab) of both groups were observed. It was indicated by results that ANA antibody level and positive rates of anti-Sm, anti-SSA and anti-SSB antibodies were significantly lower in the TB group than those in the control group (P < 0.05); C3 and C4 levels were significantly higher in the TB group than those in the control group; damage of hematological system (predominantly platelet) was less severe in the TB group than that in the control group (P < 0.05); no significant differences in IgG, IgM and IgA were noted between two groups (P > 0.05); ESR, C-reactive protein and LDH levels were significantly higher in the TB group than those in the control group (P < 0.05); PPD-IgG were significantly higher in the TB group than those in the control group (P < 0.05). These results suggested that after SLE patients were infected with tuberculosis, immune function was altered and lupus activity was inhibited as well.
Department of Internal Medicine, Huang Pu Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China. zhcr2303@sina.com
Chang-Ran
CR
Zhang
Yuan-Yuan
YY
Niu
Jian-Cong
JC
Lin
Wen-Hui
WH
Wu
Ming
M
Li
Jian-Feng
JF
Li
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D008297:Male; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
D001323:Autoantibodies; D003165:Complement System Proteins