Metal ion-promoted conformational changes of oligonucleotides.
The review will discuss the influence of metal ions on conformational changes of oligonucleotides. First, a short definition of the torsion angles is given, followed by a concise yet critical overview of the commonly applied experimental techniques. Finally, the possible role of metals upon the following conformational changes of oligonucleotides is discussed: (i) the denaturation of double-strands, (ii) the transition from B- to A-DNA, (iii) the transition from right- to left-handed DNA and RNA, (iv) the condensation, (v) and other conformational changes. We conclude with a summary and outlook.
Institute of Inorganic Chemistry, University of Zürich, Zürich, Switzerland. spingler@aci.uzh.ch
Bernhard
B
Spingler
D007477:Ions / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
D007477:Ions; D008670:Metals; D009841:Oligonucleotides