Cytotoxic activity and cell cycle analysis of hexahydrocurcumin on SW 480 human colorectal cancer cells.
The cytotoxicity of hexahydrocurcumin and its effect on the cell cycle in human colorectal cancer cells SW480 has been studied for the first time. The compound, extracted from Zingiber officinale, was shown to be cytotoxic to colorectal cancer cells. Treatment of SW480 cells with hexahydrocurcumin (100 microM) resulted in a massive accumulation of the cells in the G1/G0 phase of the cell cycle. The cytotoxic effect of hexahydrocurcumin may prove useful in cancer prevention.
Department of Medical Laboratory and Biotechnical Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung County 831, Taiwan, ROC.
Chung-Yi
CY
Chen
Woei-Ling
WL
Yang
Soong-Yu
SY
Kuo
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans
D000972:Antineoplastic Agents, Phytogenic; C569902:hexahydrocurcumin; D003474:Curcumin