Hospitalizations for intussusception before and after the reintroduction of rotavirus vaccine in the United States.
OBJECTIVE
To determine whether hospital discharges for intussusception in children younger than 1 year have changed since the reintroduction of rotavirus vaccine in the United States.


METHODS
Serial cross-sectional analysis.


METHODS
US hospitals.


METHODS
Children younger than 1 year with a discharge diagnosis of intussusception identified in the Kids' Inpatient Database, a series of nationally representative data sets of pediatric hospital discharges in the United States with 4 available years prior to vaccine reintroduction (1997, 2000, 2003, and 2006) and 1 year after (2009).


METHODS
Hospital discharge before vs after rotavirus vaccine reintroduction.


METHODS
Total number and rate of hospital discharges for infants younger than 1 year with a diagnosis of intussusception (International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0).


RESULTS
From 1997 to 2006, there was no change in the total number of hospital discharges for intussusception, with a small decrease in the rate of intussusception discharges (41.6 [95% CI, 36.7-46.5] to 36.5 [95% CI, 31.7-41.2] per 100,000 infants). Based on the trend, the predicted rate of discharges for intussusception in 2009 was 36.0 (95% CI, 30.2-41.8) per 100,000 infants. The measured rate of hospital discharges for intussusception in 2009 was 33.3 (95% CI, 29.0-37.6) per 100,000 infants.


CONCLUSIONS
The reintroduction of rotavirus vaccine since 2006 has not resulted in a detectable increase in the number of hospital discharges for intussusception among US infants.
Department of Pediatrics, University of Michigan, 300 N Ingalls, Ann Arbor, MI 48109, USA. josephzi@umich.edu
Joseph S
JS
Zickafoose
Brian D
BD
Benneyworth
Meredith P
MP
Riebschleger
Claudia M
CM
Espinosa
Matthew M
MM
Davis
D016907:Adverse Drug Reaction Reporting Systems; D003430:Cross-Sectional Studies; D005260:Female; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007297:Inpatients / Q000706:statistics & numerical data*; D007443:Intussusception / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D019233:Retreatment; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
D022243:Rotavirus Vaccines