Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice.
A novel three-dimension micro-device was formulated to control delivery of 5-fluorouracil (5-FU) for the treatment of solid tumors. The poly-(lactic-co-glycolic) acid (PLGA), which is both biocompatible and biodegradable, was used as carrier material. The characteristics of drug release in vitro and in vivo and the performance of the micro-device after implantation in tumor bearing mice were evaluated. A constant release profile from in vitro test was obtained for a period of 7 days, and it correlated well with the in vivo release profile. In the distribution experiment of 5-FU micro-device, it was demonstrated that 5-FU remained in the tumor tissues for more than 7 days after implantation. Likewise, we found that the 5-FU concentration in tumor correlated well with the in vivo release. Tumors treated with 5-FU loaded micro-device of three different dosages showed significant tumor reduction (P < 0.05) compared with empty control micro-device 7 days after administration. Moreover, the implantation treatment showed enhanced efficacy compared with the intraperitoneal administration with the same dosage. These results suggested that the three-dimensional micro-device may provide a promising local and controlled release drug delivery system, which may enable delivery of multiple drugs for post-surgical chemotherapy against solid tumor.
School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.
Xiaojiao
X
Ren
Na
N
Zheng
Yang
Y
Gao
Tianning
T
Chen
Wen
W
Lu
D020341:Absorbable Implants; D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000378:metabolism*; D019344:Lactic Acid / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011897:Random Allocation; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005472:Fluorouracil