Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications.
Scaffolds constituted by micro and nanofibers of silk fibroin were obtained by electrospinning. Fibers of fibroin meshes were coated with polypyrrole (pPy) by chemical polymerization; chemical linkages between polymers were observed by SEM and IR spectroscopy. Mechanical resistance of the meshes was improved by polypyrrole coating. Furthermore, coated meshes present a high electroactivity allowing anion storage and delivery during oxidation/reduction reactions in aqueous solutions. Uncoated and pPy coated materials support the adherence and proliferation of adult human mesenchymal stem cells (ahMSCs) or human fibroblasts (hFb). The bioactivity of fibroin mesh overcomes that of the polypyrrole coated meshes.
Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario (IMIDA), La Alberca (Murcia), E-30150, Spain.
Salvador
S
Aznar-Cervantes
Maria I
MI
Roca
Jose G
JG
Martinez
Luis
L
Meseguer-Olmo
Jose L
JL
Cenis
Jose M
JM
Moraleda
Toribio F
TF
Otero
D002448:Cell Adhesion; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005347:Fibroblasts; D005349:Fibroins; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010084:Oxidation-Reduction; D011108:Polymers; D011758:Pyrroles; D047011:Silk; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D011108:Polymers; D011758:Pyrroles; D047011:Silk; C067635:polypyrrole; D005349:Fibroins