Chronic administration of cardanol (ginkgol) extracted from ginkgo biloba leaves and cashew nutshell liquid improves working memory-related learning in rats.
Cardanol (ginkgol) extracted from Ginkgo biloba leaves and cashew nutshell liquid enhances the growth of NSC-34 immortalized motor neuron-like cells and, when chronically administered to young rats, improves working memory-related learning ability as assessed by eight-arm radial maze tasks. These findings suggest that cardanol is one of the components in Ginkgo biloba leaves that improves cognitive learning ability.
Showa Pharmaceutical University, Higashi-tamagawagakuen, Machida, Tokyo 194–8543, Japan.
Seisho
S
Tobinaga
Michio
M
Hashimoto
Iku
I
Utsunomiya
Kyoji
K
Taguchi
Morihiko
M
Nakamura
Tokugoro
T
Tsunematsu
D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D020441:Ginkgo biloba / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000517:prevention & control*; D008570:Memory, Short-Term / Q000187:drug effects*; D009754:Nuts; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D010636:Phenols; D010936:Plant Extracts; C038590:cardanol