Synchronous carcinoma of the ascending colon and caecum.
The caecum and the ascending colon are the colon segments most frequently affected by tumoral synchronism. Synchronous colorectal carcinoma etiopathogenesis is complex and most likely by malignancy of preexisting adenomas (adenoma-adenocarcinoma sequence). The following tumoral synchronism clinical case's particularity is represented by the simultaneous diagnosis of a flat-type adenocarcinoma of the caecum (less common histopathological type) and of a mucinous adenocarcinoma on the ascending colon. Tumor profiles of both carcinomas were examined histologically and immunohistochemically, emphasizing: (1) tumor proliferation different histological type; (2) residual adenomas in the periphery of the flat-type adenocarcinoma; (3) hardly microscopic detectable invasive character of the flat-type carcinoma; (4) mucinous carcinoma's infiltrating character and its immunohistochemical phenotype; (5) both tumor aggressiveness.
Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Corina
C
Gruia
Camelia
C
Foarfă
Liliana
L
Streba
P
P
Mănescu
D018256:Adenomatous Polyps / Q000473:pathology; D000368:Aged; D019011:Antigens, CD7 / Q000378:metabolism; D000071616:CDX2 Transcription Factor; D002432:Cecum / Q000000981:diagnostic imaging / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D044682:Colon, Ascending / Q000000981:diagnostic imaging / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D055262:Mucin-2 / Q000378:metabolism; D009093:Mucus / Q000378:metabolism; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
D019011:Antigens, CD7; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; D055262:Mucin-2