Impact of discontinuous treatments on disease dynamics in an SIR epidemic model.
We consider an SIR epidemic model with discontinuous treatment strategies. Under some reasonable assumptions on the discontinuous treatment function, we are able to determine the basic reproduction number R₀, confirm the well-posedness of the model, describe the structure of possible equilibria as well as establish the stability/instability of the equilibria. Most interestingly, we find that in the case that an equilibrium is asymptotically stable, the convergence to the equilibrium can actually be achieved in finite time, and we can estimate this time in terms of the model parameters, initial sub-populations and the initial treatment strength. This suggests that from the view point of eliminating the disease from the host population, discontinuous treatment strategies would be superior to continuous ones. The methods we use to obtain the mathematical results are the generalized Lyapunov theory for discontinuous differential equations and some results on non-smooth analysis.
College of Mathematics and Econometrics, Hunan University, Changsha, Hunan 410082, China. gzhenyuan@yahoo.com.cn
Zhenyuan
Z
Guo
Lihong
L
Huang
Xingfu
X
Zou
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D050936:Basic Reproduction Number; D003141:Communicable Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D008954:Models, Biological
D000890:Anti-Infective Agents