Linking MRI to daily life experience: the example of poststroke depression.
OBJECTIVE
The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide information that is complementary to MRI data, using the illustration of poststroke depression.


METHODS
MRI examinations were provided to 15 stroke patients, followed by computerized ambulatory monitoring of daily life experiences over 1 week.


RESULTS
The occurrence of daily life events was significantly associated with the intensity of positive affect during the ambulatory monitoring period. This emotional reactivity was also significantly associated with functional connectivity in brain regions linked with the risk of depression 3 months following stroke.


CONCLUSIONS
Novel mobile technologies provide information that is inaccessible to hospital-based tests, and allow for more complete investigations of disorder expression and etiology.
National Center for Scientific Research (INCIA, CNRS 5287), Bordeaux, France.
S
S
Lassalle-Lagadec
M
M
Allard
B
B
Dilharreguy
P
P
Schweitzer
J
J
Swendsen
I
I
Sibon
D000339:Affect / Q000502:physiology; D000368:Aged; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D003866:Depressive Disorder / Q000209:etiology* / Q000473:pathology*; D004644:Emotions / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008016:Life Change Events; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D020521:Stroke / Q000150:complications* / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology