Kinetochore flexibility: creating a dynamic chromosome-spindle interface.
Kinetochores are complex macromolecular assemblies that link chromosomes to the mitotic spindle, mediate forces for chromosome motion, and generate the checkpoint signal delaying anaphase onset until all chromosomes are incorporated into the spindle. Proper execution of these functions depends on precise interactions between kinetochores and microtubules. While the molecular composition of the kinetochore is well described, structural organization of this organelle at the molecular and atomic levels is just beginning to emerge. Recent structural studies across scales suggest that kinetochores should not be viewed as rigid static scaffolds. Instead, these organelles exhibit a surprising degree of flexibility that enables rapid adaptations to various types of interactions with the mitotic spindle.
Nikon Instruments Inc., Melville, NY 11747, United States.
Christopher B
CB
O'Connell
Alexey
A
Khodjakov
Bruce F
BF
McEwen
D000705:Anaphase; D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D008941:Spindle Apparatus / Q000737:chemistry / Q000378:metabolism*