The role of mTOR signaling in Alzheimer disease.
The buildup of Abeta and tau is believed to directly cause or contribute to the progressive cognitive deficits characteristic of Alzheimer disease. However, the molecular pathways linking Abeta and tau accumulation to learning and memory deficits remain elusive. There is growing evidence that soluble forms of Abeta and tau can obstruct learning and memory by interfering with several signaling cascades. In this review, I will present data showing that the mammalian target of rapamycin (mTOR) may play a role in Abeta and tau induced neurodegeneration.
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. oddo@uthscsa.edu
Salvatore
S
Oddo
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D006801:Humans; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
D058570:TOR Serine-Threonine Kinases