Facile synthesis, antioxidant and antimicrobial activity of amino methylene bisphosphonates.
A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are characterized by IR, (1)H-, (13)C-, (31)P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India.
Uma Maheswara Rao
UM
Kunda
Satheesh Krishna
SK
Balam
Bakthavatchala Reddy
BR
Nemallapudi
Syama Sundar
SS
Chereddy
Sandip Kumar
SK
Nayak
Suresh Reddy
SR
Cirandur
D000588:Amines / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002384:Catalysis; D004164:Diphosphonates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005561:Formates / Q000737:chemistry; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D017905:Phosphites / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry; D013696:Temperature
D000588:Amines; D000890:Anti-Infective Agents; D000975:Antioxidants; D004164:Diphosphonates; D005561:Formates; D017905:Phosphites; D013343:Styrenes; C528218:amberlyst-15; C030544:formic acid