Acetylcholinesterase inhibition starting from extracts of Bauhinia variegata L., Bauhinia var. candida (Aiton) Buch.-Ham., and Bauhinia ungulata L.
BACKGROUND
A treatment to the Alzheimer's disease consists inhibition of the acetylcholinesterase, which is responsible for the acetylcholine control in the synapses.


METHODS
We have investigated the potential of inhibition of the acetylcholinesterase produced by hexane extracts of leaves, branches, and flowers from three Bauhinia specimens, which is based on the technique of thin layer chromatography and on identifying the organ of the plant that possesses larger concentration of inhibitors.


RESULTS
Retention factor analysis shows values of 0.31aA, 0.31aA, and 0.46aB for flowers B. variegata, B. var. candida, and B. ungulata, respectively.


CONCLUSIONS
The flower extract of B. ungulata is the most suitable for further studies on this inhibition.
Faculdade de Biomedicina, Universidade José do Rosário Vellano, Divinópolis, MG, Brasil. kamillamonteiro7@hotmail.com
Kamilla Monteiro dos
KM
Santos
Priscila Sant'Ana
PS
Gonçalves
Maria José Nunes de
MJ
Paiva
Guilherme Araújo
GA
Lacerda
D036481:Bauhinia / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D002855:Chromatography, Thin Layer; D035264:Flowers / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
D002800:Cholinesterase Inhibitors; D010936:Plant Extracts