Neurocognitive functioning in youth with pediatric autoimmune neuropsychiatric disorders associated with streptococcus.
This study evaluated neurocognitive functioning in 26 youth with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and primarily obsessive-compulsive disorder (OCD) symptoms. Marked impairment in visuospatial recall memory (as assessed using the Rey-Osterrieth Complex Figure Test) was observed in spite of average to above-average performance on academic and other neurocognitive measures. Group A beta-hemolytic Streptococcus titer elevations were associated with worse performance on tasks of neurocognitive and executive ability (Stroop Color-Word Interference Test), visuospatial memory, and fine motor speed (finger tapping) as well as elevated obsessive-compulsive symptom severity.
University of South Florida College of Medicine, Department of Pediatrics, Rothman Center for Neuropsychiatry, USA. alewin@health.usf.edu
Adam B
AB
Lewin
Eric A
EA
Storch
P Jane
PJ
Mutch
Tanya K
TK
Murphy
D000293:Adolescent; D000989:Antistreptolysin / Q000097:blood; D001327:Autoimmune Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D013290:Streptococcal Infections / Q000150:complications*; D013291:Streptococcus / Q000472:pathogenicity
D000989:Antistreptolysin