Cyclin E low-molecular-weight isoform as a predictor of breast cancer in Japanese women.
Overexpression of low-molecular-weight isoforms (LMWI) of cyclin E in breast cancer cells is associated with poor prognosis and could serve a novel role in breast cancer progression. LMWI originate from proteolytic processing of cyclin E, which is deregulated and hyperactive. In this study, levels of full-form/LMWI cyclin E were determined with the use of Western blot analysis in 69 Japanese breast cancer patients. LMWI cyclin E levels were significantly correlated with known parameters such as tumor grade and estrogen/progesterone receptor expression. In multivariate analysis, patient survival was significantly correlated with tumor grade but not with either form of cyclin E. LMWI was not as strong a predictor as tumor grade in this study, whereas some cases of early relapse with LMWI overexpression and lower tumor grade were reported. Thus, LMWI might be a good complementary factor to other predictors for early relapse of breast cancer.
Division of Breast and Endocrine Surgery, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yukiko
Y
Tokai
Shigeto
S
Maeda
Junzo
J
Yamaguchi
Tatsuya
T
Uga
Naomi
N
Hayashida
Ken
K
Taniguchi
Susumu
S
Eguchi
Takashi
T
Kanematsu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism*; D019927:Cyclin E / Q000378:metabolism*; D005260:Female; D006801:Humans; D007564:Japan; D008875:Middle Aged; D008970:Molecular Weight; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011379:Prognosis; D020033:Protein Isoforms
D019927:Cyclin E; D020033:Protein Isoforms