Use of an in vitro model of renal replacement therapy systems to estimate extracorporeal drug removal.
The use of in vitro modeling to predict in vivo drug and solute clearance during renal replacement therapy has evolved to reflect the different dialytic therapies available in clinical practice. This area of renal replacement therapy research is representative of translational research that demonstrates a correlation from bench to bedside where results generated in the laboratory can assist with clinical decisions in the absence of in vivo studies. This review describes in vitro renal replacement therapy models and compares the findings of several in vitro and in vivo studies.
University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, MS 1013, Toledo, OH, USA. mariann.churchwell@utoledo.edu
Mariann D
MD
Churchwell
D000818:Animals; D006801:Humans; D008657:Metabolic Clearance Rate; D010599:Pharmacokinetics; D017582:Renal Replacement Therapy