Regulation of transcription in cancer.
The purpose of this article is to provide an overview on the regulation of transcription in cancer cells. We describe here standard mechanisms of transcription in eukaryotic cells, an influence of common promoter polymorphisms contributing to malignant progression and DNA methylation as significant aspect of gene regulation. We also described transcription factors mechanism of action, and how their alteration can result in cancer.
Departament of Transplantation, Polish-American Institute of Pediatry, Jagiellonian University School of Medicine, Krakow, Poland.
Elzbieta
E
Trzyna
Marcin
M
Duleba
Marta
M
Faryna
Marcin
M
Majka
D019175:DNA Methylation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics; D014158:Transcription, Genetic
C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met