Atrial remodeling in atrial fibrillation and association between microRNA network and atrial fibrillation.
Atrial fibrillation (AF) remains one of the leading causes of morbidity and mortality in the world which are related to palpitations, fainting, congestive heart failure or stroke. The mechanism for atrial fibrillation has been identified as electrical remodeling, structure remodeling and intracellular calcium handling remodeling. microRNAs (miRNAs) have recently emerged as one of the important factors in regulating gene expression. So far, thousands of miRNA genes have been found in diverse animals with the function of regulating cell death, cell proliferation, haematopoiesis and even participate in the processing of cardiovascular disease. In this review, we summarize the mechanism of AF and the association of microRNAs network with AF. We provide a potential perspective of miRNAs as the therapeutic target for AF.
Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin 150086, China.
Ying
Y
Zhang
Deli
D
Dong
Baofeng
B
Yang
D001281:Atrial Fibrillation / Q000235:genetics / Q000503:physiopathology*; D006325:Heart Atria / Q000033:anatomy & histology* / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
D035683:MicroRNAs