Molecular view on PRR cross-talk in antifungal immunity.
The identification of a major class of innate immune receptors, termed pattern recognition receptors (PRRs), has boosted research on innate pathogen recognition. The immune response to a specific pathogen is not restricted to the recognition by one type of PRR or activation of a single cell type, but instead comprises complex collaborations between different receptors, cells and signal mediators. Here we will discuss the cross-talk between PRRs involved in fungal recognition, focusing on the molecular interactions occurring at the plasma membrane.
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
S
S
Hontelez
A
A
Sanecka
M G
MG
Netea
A B
AB
van Spriel
G J
GJ
Adema
D000818:Animals; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity; D002177:Candidiasis / Q000276:immunology / Q000382:microbiology; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D037181:Lectins, C-Type / Q000276:immunology; D053473:Nod2 Signaling Adaptor Protein / Q000276:immunology; D020239:Receptor Cross-Talk; D011971:Receptors, Immunologic; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
D037181:Lectins, C-Type; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases