Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats.
Supplementation with lupeol (0.67 g·kg(-1)) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. ardy@biochem.tohoku.ac.jp
Ardiansyah
Eri
E
Yamaguchi
Hitoshi
H
Shirakawa
Keishi
K
Hata
Kazuyuki
K
Hiwatashi
Kousaku
K
Ohinata
Tomoko
T
Goto
Michio
M
Komai
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D019587:Dietary Supplements; D004198:Disease Susceptibility; D004435:Eating / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D053978:Pentacyclic Triterpenes / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke; D000094042:Lupanes
D053978:Pentacyclic Triterpenes; C010480:lupeol; D000094042:Lupanes