Charge transfer through modified peptide nucleic acids.
We studied the charge transfer properties of bipyridine-modified peptide nucleic acid (PNA) in the absence and presence of Zn(II). Characterization of the PNA in solution showed that Zn(II) interacts with the bipyridine ligands, but the stability of the duplexes was not affected significantly by the binding of Zn(II). The charge transfer properties of these molecules were examined by electrochemistry for self-assembled monolayers of ferrocene-terminated PNAs and by conductive probe atomic force microscopy for cysteine-terminated PNAs. Both electrochemical and single molecular studies showed that the bipyridine modification and Zn(II) binding do not affect significantly the charge transfer of the PNA duplexes.
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Emil
E
Wierzbinski
Arnie
A
de Leon
Kathryn L
KL
Davis
Silvia
S
Bezer
Matthäus A
MA
Wolak
Matthew J
MJ
Kofke
Rudy
R
Schlaf
Catalina
C
Achim
David H
DH
Waldeck
D015082:2,2'-Dipyridyl / Q000737:chemistry; D020029:Base Pairing; D004563:Electrochemistry; D004579:Electron Transport; D008958:Models, Molecular; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013053:Spectrophotometry; D013696:Temperature; D015032:Zinc / Q000737:chemistry
D020135:Peptide Nucleic Acids; D015082:2,2'-Dipyridyl; D015032:Zinc