Non-coding RNAs as theranostics in human cancers.
Theranostics was coined originally as a term used to describe a system that combines diagnosis and therapy, aiming to provide the tools for personalized medicine. This review reasserts the grounds for regarding non-coding RNAs (ncRNA) as theranostics in human cancers. The microRNAs (miRNAs) are the most well studied ncRNAs in recent years; their pivotal role in orchestrating tumor initiation and progression has been confirmed in all types of cancers. Hence, these small ncRNAs have emerged as attractive therapeutic targets and diagnostic tool. Various approaches to use their therapeutic potential have been taken, here we summarize the most important ones. In the near future, the focus of theranostics will be shifted towards longer and mechanistically more versatile ncRNAs, and we included some recent advances supporting this view.
Department of Molecular Science, University of Medicine and Pharmacy I. Hatieganu, Cluj-Napoca, Romania.
Roxana S
RS
Redis
Ioana
I
Berindan-Neagoe
Victor I
VI
Pop
George A
GA
Calin
D000229:Dependovirus / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D016147:Genes, Tumor Suppressor; D005822:Genetic Vectors; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics; D018716:Molecular Mimicry; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009841:Oligonucleotides / Q000235:genetics / Q000627:therapeutic use; D009857:Oncogenes; D057285:Precision Medicine; D016372:RNA, Antisense / Q000235:genetics / Q000627:therapeutic use; D012334:RNA, Neoplasm / Q000037:antagonists & inhibitors / Q000235:genetics*; D022661:RNA, Untranslated / Q000037:antagonists & inhibitors / Q000235:genetics*
D035683:MicroRNAs; D009841:Oligonucleotides; D016372:RNA, Antisense; D012334:RNA, Neoplasm; D022661:RNA, Untranslated; C477371:locked nucleic acid