Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size.
Solid lipid nanoparticle (SLN) is a very well tolerated carrier systems for dermal application due to the employment physiological and/or biodegradable lipids. The effects of five factors, two categorical and three quantitative factors, were studied on the mean diameter and entrapment efficiency of the produced SLNs using response surface method (RSM), D-optimal design. Two methods of microemulsion and solvent diffusion and two types of lipid, cetyl palmitate and stearic acid, were examined comparatively. The quantitative variables were studied in three levels; amount of original Paromomycin (60, 90 and 120 mg), fraction of surfactant (0.5, 0.75 and 1 w/v %) and drug to lipid ratio (2, 4 and 6). Mean particle size and entrapment efficiency of the loaded Paromomycin were modeled statistically and the optimal condition was determined to approach to the maximum entrapment efficiency. The drug release profile of the optimal formulated material was examined in aqueous media and 64% of the Paromomycin loaded in SLNs was gradually released during 24h, which reveals efficient prolonged release of the drug.
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Maryam
M
Ghadiri
Shohreh
S
Fatemi
Alireza
A
Vatanara
Delaram
D
Doroud
Abdolhossein Rouholamini
AR
Najafabadi
Majid
M
Darabi
Amir Abbas
AA
Rahimi
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D006601:Hexoses / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D015233:Models, Statistical; D053758:Nanoparticles / Q000737:chemistry*; D010168:Palmitates / Q000737:chemistry*; D010303:Paromomycin / Q000737:chemistry*; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry
D004337:Drug Carriers; D006601:Hexoses; D010168:Palmitates; D011136:Polysorbates; D013229:Stearic Acids; D013501:Surface-Active Agents; C031183:stearic acid; C006957:cetyl palmitate; D010303:Paromomycin; C005693:sorbitan trioleate