Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women.
OBJECTIVE
The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA).


METHODS
We conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss.


RESULTS
RSA patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042–2.417) and miR-499AG+GG genotypes (AOR, 1.587; 95% CI, 1.096–2.298) [corrected] compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645–7.624).


CONCLUSIONS
miR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women.
Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Young Joo
YJ
Jeon
Yi Seul
YS
Choi
Hyungchul
H
Rah
Su Yeoun
SY
Kim
Dong Hee
DH
Choi
Sun Hee
SH
Cha
Ji Eun
JE
Shin
Sung Han
SH
Shim
Woo Sik
WS
Lee
Nam Keun
NK
Kim
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea; D035683:MicroRNAs; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012306:Risk
D035683:MicroRNAs