Advancements in Z-DNA: development of inducers and stabilizers for B to Z transition.
Z-DNA, an active element in genome, has drawn intense interest in chemical and biological field. Its dynamic and transient state makes it challenging to target and regulate. Thus, stabilizing and inducing Z-DNA both in vitro and in vivo is essential, so far, much many efforts have been made in these aspects. However, Z-DNA's induction and stabilization are always performed in high salt condition and sequence-dependent, limited inducers or stabilizers have been achieved with breakthrough in the aspects of real physiological condition and sequence-independence. Herein, we give a review of some typical kinds of Z-DNA inducers and stabilizers, discussing their inducing or stabilizing condition, mechanism, structural relationship and their limitation as well, attempted to get some implication and guidance for Z-DNA inducer or stabilizer design.
State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, P. R. of China.
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L
Yang
S
S
Wang
T
T
Tian
X
X
Zhou
D043542:DNA, Z-Form / Q000737:chemistry* / Q000187:drug effects*; D006151:Guanosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013096:Spermine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D043542:DNA, Z-Form; D009942:Organometallic Compounds; D006151:Guanosine; D013096:Spermine