The rheological and structural properties of Fmoc-peptide-based hydrogels: the effect of aromatic molecular architecture on self-assembly and physical characteristics.
Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These materials offer three-dimensional scaffolds to support the growth of cells and development of hierarchical tissue structures. Fmoc-peptides were previously demonstrated as attractive building blocks for biocompatible hydrogels. Here, we further investigate the biophysical properties of Fmoc-peptide-based hydrogels for medical applications. We describe the structural and thermal properties of these Fmoc-peptides, as well as their self-assembly process. Additionally, we study the role of interactions between aromatic moieties in the self-assembly process and on the physical and structural properties of the hydrogels.
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel-Aviv University, Tel-Aviv 69978, Israel.
Ron
R
Orbach
Iris
I
Mironi-Harpaz
Lihi
L
Adler-Abramovich
Estelle
E
Mossou
Edward P
EP
Mitchell
V Trevor
VT
Forsyth
Ehud
E
Gazit
Dror
D
Seliktar
D005449:Fluorenes / Q000737:chemistry*; D020100:Hydrogels; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012212:Rheology; D013057:Spectrum Analysis
C496789:9-fluorenylmethoxycarbonyl; D005449:Fluorenes; D020100:Hydrogels; D010455:Peptides