[Influence high-fat ration on plasma and erythrocyte lipids fatty acids of rats].
Study character of the redistribution of fatty acids between the lipid fraction of plasma and erythrocytes in rats with prolonged high-fat diet (30, 90, 180 days). Shown that at long high-fat rations in the lipids of erythrocytes decreasing pool polyunsaturated fatty acids (oleic, dihomo-gamma-linoleic, eicosapentaenoic, arachidonic), increases of saturated fatty acids (myristic, stearic) levels. In lipids fractions of plasma revealed the opposite direction of changes in the level of the fatty acids: the accumulation of essential polyunsaturated fatty acids, reduction of saturated fatty acids. Supposedly, that high-fat diet promotes de novo compensatory synthesis of polyunsaturated fatty acids, but disturbed apoB-100 receptor-mediated active transport of fatty acids with low-density lipoproteins (LDL), synthesized in the liver fatty acids is not captured by the cells peripheral organs. Marker of the apoB-100 receptor breach of transfer low-density lipoprotein, transporting polyunsaturated fatty acids was to increase LDL cholesterol in serum.
T P
TP
Novgorodtseva
Iu K
IuK
Karaman
N V
NV
Zhykova
D000818:Animals; D053299:Apolipoprotein B-100 / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood* / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
D053299:Apolipoprotein B-100; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D008563:Membrane Lipids