Do differences in Panton-Valentine leukocidin production among international methicillin-resistant Staphylococcus aureus clones affect disease presentation and severity?
Panton-Valentine leukocidin (PVL) production by methicillin-resistant Staphylococcus aureus (MRSA) was determined in vitro using the enzyme-linked immunosorbent assay (ELISA), and associations with clinical presentation and bacterial genetic characteristics were examined. PVL production ranged from 0.02 to 4.865 μg/ml and correlated with a multilocus sequence type (MLST) clonal complex associated with specific PVL phage types. A relationship between PVL production and clinical presentation or patient demographics could not be demonstrated.
Staphylococcus Reference Unit, Microbiology Services Colindale, Health Protection Agency, London, United Kingdom.
Eve
E
Boakes
Angela M
AM
Kearns
Cederic
C
Badiou
Gerard
G
Lina
Robert L
RL
Hill
Matthew J
MJ
Ellington
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001427:Bacterial Toxins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005098:Exotoxins / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007956:Leukocidins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification* / Q000302:isolation & purification / Q000472:pathogenicity*; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology*; D037521:Virulence Factors / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors