Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.
Single-nucleotide polymorphisms (SNPs) of TERT rs2736098, rs2736100, and CLPTM1L rs402710 at 5p15.33 are significantly associated with risk of a spectrum of cancers. However, cervical cancer has been rarely evaluated. In this study, we genotyped the three SNPs in a case-control study with 1,033 cervical cancer cases and 1,053 cancer-free controls in a Chinese population. Logistic regression analyses showed that the two TERT SNPs both significantly associated with cervical cancer risk in the recessive model (rs2736098, AA vs.
adjusted OR = 1.35, 95% CI = 1.06-1.72; rs2736100, CC vs. AC/AA: adjusted OR = 1.38, 95% CI = 1.11-1.73). However, no association was found between CLPTM1L rs402710 and cervical cancer. These results suggest that genetic variants in 5p15.33, especially in TERT, may be markers for susceptibility to cervical cancer.
Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, China.
Sumin
S
Wang
Jiangping
J
Wu
Lingmin
L
Hu
Chenyue
C
Ding
Yanjing
Y
Kan
Yan
Y
Shen
Xiaojun
X
Chen
Hongbing
H
Shen
Xirong
X
Guo
Zhibin
Z
Hu
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008572:Menarche; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011897:Random Allocation; D019098:Telomerase / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
C509186:TERT protein, human; D019098:Telomerase