Gene regulatory networks reused to build novel traits: co-option of an eye-related gene regulatory network in eye-like organs and red wing patches on insect wings is suggested by optix expression.
Co-option of the eye developmental gene regulatory network may have led to the appearance of novel functional traits on the wings of flies and butterflies. The first trait is a recently described wing organ in a species of extinct midge resembling the outer layers of the midge's own compound eye. The second trait is red pigment patches on Heliconius butterfly wings connected to the expression of an eye selector gene, optix. These examples, as well as others, are discussed regarding the type of empirical evidence and burden of proof that have been used to infer gene network co-option underlying the origin of novel traits. A conceptual framework describing increasing confidence in inference of network co-option is proposed. Novel research directions to facilitate inference of network co-option are also highlighted, especially in cases where the pre-existent and novel traits do not resemble each other.
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA. antonia.monteiro@yale.edu
Antónia
A
Monteiro
D000818:Animals; D005075:Biological Evolution; D002080:Butterflies / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D054910:Compound Eye, Arthropod / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D017344:Genes, Insect; D005809:Genes, Regulator; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D010858:Pigmentation; D010860:Pigments, Biological / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation; D014921:Wings, Animal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C409102:Optix protein, Drosophila; D010860:Pigments, Biological; D014157:Transcription Factors