Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species.
Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide. The pathogen has been associated with serious health consequences including predisposition to cervical cancer and adverse pregnancy outcomes and infertility. It also acts as a co-factor in HIV transmission and acquisition. The 5-nitroimidazole drugs are used in the treatment, however, treatment noncompliance is observed, and a growing number of T. vaginalis isolates resistant to the drugs have been related. Saponins are natural products possessing many biological activities such as antiprotozoan activity. The aim of this study was to evaluate the anti-T. vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Saponins from Passiflora alata and Quillaja saponaria presented the best anti-T. vaginalis activity (MIC = 0.025%). In addition, all samples induced erythrocyte lysis and LDH release. As far as we know, this is the first report demonstrating the potential anti-T. vaginalis activity of these saponins.
Laboratório de Fitoquímica e Síntese Orgânica, Departamento de Produção de Matéria-Prima, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Rio Grande do Sul, Brazil.
Tábitha Dahmer
TD
Rocha
Patrícia
P
de Brum Vieira
Simone Cristina Baggio
SC
Gnoatto
Tiana
T
Tasca
Grace
G
Gosmann
D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects; D006802:Human Activities; D030017:Ilex / Q000737:chemistry*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D021261:Parasitic Sensitivity Tests; D029598:Passiflora / Q000737:chemistry*; D031990:Quillaja / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000981:Antiprotozoal Agents; D012503:Saponins; D007770:L-Lactate Dehydrogenase