Spherical nucleic acids.
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them. Important examples of technological advances made possible by their fundamental properties spanning the fields of chemistry, molecular diagnostics, gene regulation, medicine, and materials science are also presented.
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Joshua I
JI
Cutler
Evelyn
E
Auyeung
Chad A
CA
Mirkin
D049673:History, 20th Century; D049674:History, 21st Century; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000266:history / Q000379:methods; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*
D009696:Nucleic Acids