An estimation method of the clearance for a one-compartment model of a single bolus intravenous injection by a single sampling.
In clinical trials, sometimes only a single drug concentration can be measured from a patient, because of the burden on the patient. From a single concentration, we cannot generally obtain point estimates of each pharmacokinetic parameter in a patient. In this article, we propose a method to estimate the clearance using a one-compartment model of a single-bolus intravenous injection from a single concentration at a sampling point between 1.5 and 2.5 half-lives. This method requires an assumed value for the volume of distribution but is robust to misspecification. This approach is illustrated by simulated concentration data and cadralazine concentration data.
Vanderbilt-Ingram Cancer Center, Cancer Biostatistics Center, Nashville, Tennessee 37232-6838, USA. i-funatogawa@umin.ac.jp
Takashi
T
Funatogawa
Ikuko
I
Funatogawa
D000818:Animals; D001499:Bayes Theorem; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate / Q000502:physiology*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*
D004364:Pharmaceutical Preparations