Epidemiology and control of human granulocytic anaplasmosis: a systematic review.
Granulocytic anaplasmosis caused by Anaplasma phagocytophilum is an emerging tick-borne zoonosis worldwide. The obligate intracellular pathogen is transmitted by Ixodes ticks and infects neutrophils in humans and animals, resulting in clinical symptoms ranging from asymptomatic seroconversion to mild, severe, or fatal disease. Since the initial description of human granulocytic anaplasmosis (HGA) in the United States in 1990, HGA has been increasingly recognized in America, Europe, and Asia. This review describes the epidemiology, diagnosis, and treatment of HGA and provides background information on the potential vectors and reservoirs of A. phagocytophilum.
Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin Province, People's Republic of China.
Hongtao
H
Jin
Feng
F
Wei
Quan
Q
Liu
Jun
J
Qian
D041081:Anaplasma phagocytophilum / Q000472:pathogenicity*; D000712:Anaplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003140:Communicable Disease Control / Q000379:methods*; D004197:Disease Reservoirs; D004199:Disease Vectors; D004318:Doxycycline / Q000627:therapeutic use; D006098:Granulocytes / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D018884:Ixodes / Q000382:microbiology / Q000472:pathogenicity; D015995:Prevalence
D000900:Anti-Bacterial Agents; D004318:Doxycycline