A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+ chronic myeloid leukemia.
Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution.
Division of Hematology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil. morato.oliveira@yahoo.com.br
Fábio Morato
FM
de Oliveira
Leonardo
L
de Carvalho Palma
Roberto Passetto
RP
Falcão
Belinda Pinto
BP
Simões
D000328:Adult; D001752:Blast Crisis / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D018404:Isochromosomes; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D018398:Homeodomain Proteins; C097899:homeobox protein HOXA9