Increase in interleukin-6 levels is related to depressive phenomena in the acute (relapsing) phase of multiple sclerosis.
The aim of the present study was to investigate the possible connection between interleukin-6, the acute phase (relapse) of multiple sclerosis (MS), and depression. The authors determined and statistically evaluated the levels of interleukin-6 and its soluble receptor in the serum of 28 MS patients in relapsing, 14 MS patients in remission, and 20 control subjects, as well as the presence of depression among these individuals. The results of our study indicate that depression is not only very common during relapses of MS, but also that the levels of IL-6 increase during the acute phase of the disease, especially when depression is detected.
Dept. of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece. efrosink@gmail.com
Euphrosyni
E
Koutsouraki
Eleni
E
Hatzifilipou
Dimitrios
D
Michmizos
Christos
C
Cotsavasiloglou
Vassiliki
V
Costa
Stavros
S
Baloyannis
D000328:Adult; D003863:Depression / Q000097:blood* / Q000209:etiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000150:complications*; D012720:Severity of Illness Index; D055815:Young Adult
D015850:Interleukin-6