Ugi-Smiles couplings of 4-substituted pyridine derivatives: a fast access to chloroquine analogues.
4-Hydroxy and mercapto pyridines were successfully tested in Ugi-Smiles couplings. Such multicomponent reactions applied to quinoline derivatives afford a very convenient and short synthesis of antimalarial analogues.
DCSO-UMR 7652: CNRS-ENSTA-Ecole Polytechnique, Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta-paristech.fr
Laurent
L
El Kaïm
Laurence
L
Grimaud
Patil
P
Pravin
D000962:Antimalarials / Q000138:chemical synthesis*; D002738:Chloroquine / Q000031:analogs & derivatives*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013997:Time Factors
D000962:Antimalarials; D011725:Pyridines; D002738:Chloroquine; C023666:pyridine