Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.
We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.
Department of Biology, Kyushu University, Fukuoka 812-8581, Japan.
Etsuko
E
Moritsuka
Yosuke
Y
Hisataka
Miho
M
Tamura
Kentaro
K
Uchiyama
Atsushi
A
Watanabe
Yoshihiko
Y
Tsumura
Hidenori
H
Tachida
D022202:Chromosomes, Artificial, Bacterial; D032485:Cryptomeria / Q000235:genetics*; D023061:Gene Order; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic; D020506:Untranslated Regions
D020506:Untranslated Regions