Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. pontillo.a@gmail.com
Alessandra
A
Pontillo
Telma M
TM
Oshiro
Martina
M
Girardelli
Anselmo J
AJ
Kamada
Sergio
S
Crovella
Alberto J S
AJ
Duarte
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000235:genetics; D001938:Brazil; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D020170:Caspase 1 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D058847:Inflammasomes / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; C455623:CARD8 protein, human; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; C508585:IL1B protein, human; D058847:Inflammasomes; D053583:Interleukin-1beta; D047908:Intracellular Signaling Peptides and Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; C435692:NLRC4 protein, human; C427903:NLRP1 protein, human; C453881:NLRP3 protein, human; D009363:Neoplasm Proteins; D020170:Caspase 1