Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma.
OBJECTIVE
To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors.


METHODS
Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables.


RESULTS
Medulloblastoma patients showed increases in waist circumference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range.


CONCLUSIONS
Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.
Division of Pediatric Endocrinology, Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Adriana Aparecida
AA
Siviero-Miachon
Carlos Manoel de Castro
CM
Monteiro
Liliane Viana
LV
Pires
Ana Carolina
AC
Rozalem
Nasjla Saba da
NS
Silva
Antonio Sergio
AS
Petrilli
Angela Maria
AM
Spinola-Castro
D050154:Adiposity; D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy; D002318:Cardiovascular Diseases / Q000517:prevention & control; D016371:Cranial Irradiation / Q000009:adverse effects*; D004812:Epidemiologic Methods; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000532:radiotherapy; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000209:etiology*; D017741:Survivors; D016896:Treatment Outcome; D055815:Young Adult
D019382:Human Growth Hormone