[A long-term survival case of neuroendocrine tumor of the sigmoid colon with multiple liver metastases].
It has been reported that neuroendocrine tumor (NET) of the large intestine with distant metastasis is rare and carries poor prognosis. We report a case of colonic NET with hepatic metastases, who was successfully treated by combined therapy. A 71-year-old man with sigmoid colon tumor underwent sigmoidectomy and histopathological examination disclosed the tumor was NET grade 1. Multiple liver metastases and lymph node metastasis on the posterior surface of the pancreatic head were detected at the time of surgery. Trans-catheter arterial chemoembolization (TACE; doxorubicin and ethiodized oil and gelatine sponge particle) was performed. Partial response (PR) was observed after 2 times of administration. Radiation therapy was performed for the lymph node metastasis eight months after surgery and PR was observed. The patient was alive after 48 months and TACE was continued. Combined therapy including surgery, irradiation, and chemotherapy, although not yet standardized, is required against NET with hepatic metastases.
Dept. of Surgical Oncology, Tokyo Medical and Dental University Graduate School.
Shinichi
S
Yamauchi
Hiroyuki
H
Uetake
Akifumi
A
Kikuchi
Hiroaki
H
Ono
Takatoshi
T
Matsuyama
Shunsuke
S
Kato
Megumi
M
Ishiguro
Toshiaki
T
Ishikawa
Hirotoshi
H
Kobayashi
Satoru
S
Iida
Tetsuro
T
Higuchi
Masayuki
M
Enomoto
Kenichi
K
Sugihara
D000368:Aged; D016461:Chemoembolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008297:Male; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000628:therapy*; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed