Recurrent congenital fibrosarcoma with heart metastases.
Congenital fibrosarcomas are malignant tumors that arise in soft tissues. In infants this unique tumor does not commonly metastasize, even though there may be local recurrences. We report here a boy who had congenital fibrosarcoma in his right foot, which was completely excised at the age of 3 days. Four months later, a solitary encapsulated metastasis emerged in thoracic chest wall, which was operated. During adjuvant chemotherapy he developed histologically confirmed fibrosarcoma metastases in the heart. After extended treatment with cyclophosphamide/topotecan and gemcitabine/docetaxel, the heart tumors disappeared and he has been in complete remission for 3 years.
Department of Pediatrics and Pediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland. olli.lohi@uta.fi
Olli
O
Lohi
Martine
M
Vornanen
Marketta
M
Kähkönen
Kim
K
Vettenranta
Katriina
K
Parto
Mikko
M
Arola
D000069347:Erlotinib Hydrochloride; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital* / Q000473:pathology / Q000628:therapy; D006338:Heart Neoplasms / Q000556:secondary*; D006801:Humans; D007223:Infant; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011247:Pregnancy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D012008:Recurrence; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein
D000069347:Erlotinib Hydrochloride; D015514:Oncogene Proteins, Fusion; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; C484319:ETV6-NTRK3 fusion protein, human; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein