Cress seed mucilage based buccal mucoadhesive gel of venlafaxine: in vivo, in vitro evaluation.
Venlafaxine is a newer antipsychotic drug which shows first pass effect. Cress seed is also called as garden cress or green salad. This study examined the mechanical (gel strength, adhesiveness) and rheological properties of cress seed mucilage based gels that contain different ratios of carbopol 934 P (0.5-1.5%). In addition, diffusion of venlafaxine from gel formulations was evaluated. The selected formulation was further analyzed for pharmacokinetic parameters in rabbits. All formulations exhibited pseudoplastic flow with thixotropy. Formulation F5 showed the C(max) of 24.19 ± 0.72 ng/ml by buccal route of administration and 17.98 ± 1.15 ng/ml by oral route of administration. The bioavailability of F5 by buccal route was 54.44% and that of by oral route was 39.60%. A combination of the cress seed mucilage and carbopol 934 P resulted in a prolonged and higher venlafaxine delivery by buccal route of administration.
Department of Pharmaceutics, RC Patel Institute of Pharmaceutical Education & Research, Dist-Dhule, Shirpur, Maharashtra, India. nerkarpankaj@rediffmail.com
Pankaj Padmakar
PP
Nerkar
Surendra Ganeshlal
SG
Gattani
D003511:Cyclohexanols / Q000737:chemistry / Q000494:pharmacology*; D005782:Gels; D066298:In Vitro Techniques; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000069470:Venlafaxine Hydrochloride; D014783:Viscosity
D003511:Cyclohexanols; D005782:Gels; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride