'Omic approaches to preventing or managing metastatic breast cancer.
Early detection of metastasis-prone breast cancers and characterization of residual metastatic cancers are important in efforts to improve management of breast cancer. Applications of genome-scale molecular analysis technologies are making these complementary approaches possible by revealing molecular features uniquely associated with metastatic disease. Assays that reveal these molecular features will facilitate development of anatomic, histological and blood-based strategies that may enable detection prior to metastatic spread. Knowledge of these features also will guide development of therapeutic strategies that can be applied when metastatic disease burden is low, thereby increasing the probability of a curative response.
Lawrence Berkeley National Laboratory, Life Sciences Division, Cancer and DNA Damage Responses, One Cyclotron Road, Berkeley, CA 94720, USA.
Obi L
OL
Griffith
Joe W
JW
Gray
D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D023281:Genomics / Q000379:methods; D006801:Humans; D009362:Neoplasm Metastasis; D011379:Prognosis; D040901:Proteomics / Q000379:methods