CD248: reviewing its role in health and disease.
CD248, also known as endosialin or tumor endothelial marker-1 (TEM-1), is a C-type lectin-like domain (CTLD) containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. Loss-of-function studies in mice support the notion that CD248 promotes tumor growth and inflammation, observations that are stimulating interest in evaluating this molecule as a therapeutic target. In spite of these advances, the mechanisms by which CD248 modulates cancer and inflammation remain largely enigmatic. This review highlights our current understanding of CD248, its structure, pattern of expression, regulation and function in various disease processes.
Division of Hematology, Department of Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Yanet
Y
Valdez
Margarida
M
Maia
Edward M
EM
Conway
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology; D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D018836:Inflammation Mediators / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000378:metabolism*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C078203:CD248 protein, human; D018836:Inflammation Mediators