Cellular immune responses and susceptibility to HIV-1 superinfection:  a case-control study.
A case-control study was performed to determine the effects of HIV-1-specific cellular immune responses on the odds of acquiring a second HIV-1 infection (superinfection). Changes in the frequency of cytokine-producing or cytolytic CD8+ or CD4+ T cells were not associated with significant alterations in the odds of superinfection, suggesting that HIV-1 specific cellular immune responses at the level induced by chronic infection do not appear to significantly contribute to protection from HIV-1 superinfection.
Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA. cblish@stanford.edu
Catherine A
CA
Blish
Ozge C
OC
Dogan
Walter
W
Jaoko
R Scott
RS
McClelland
Kishorchandra
K
Mandaliya
Katherine S
KS
Odem-Davis
Barbra A
BA
Richardsonb
Julie
J
Overbaugh
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D016207:Cytokines / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D015163:Superinfection / Q000276:immunology* / Q000821:virology
D016207:Cytokines