Transcriptional regulation of Rho GTPase signaling.
Signaling through the Rho family of small GTPases regulates a variety of cellular processes via changes in the actin cytoskeleton. Here we discuss recent findings that show the transcription factor p53 regulates the expression of several Rho pathway signaling molecules, and how mutation of p53 in cancer dramatically alters signaling output through this pathway.
The Beatson Institute for Cancer Research, Garscube Estate; Glasgow, UK.
Daniel R
DR
Croft
Michael F
MF
Olson
D051339:Actin Depolymerizing Factors / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D017209:Apoptosis; D003599:Cytoskeleton / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D054461:Lim Kinases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D054460:rho-Associated Kinases / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism; D020743:rhoB GTP-Binding Protein / Q000378:metabolism; D000075024:rhoC GTP-Binding Protein
D051339:Actin Depolymerizing Factors; D000199:Actins; D016159:Tumor Suppressor Protein p53; C515892:LIMK1 protein, human; D054461:Lim Kinases; C515851:ROCK1 protein, human; C515852:ROCK2 protein, human; D054460:rho-Associated Kinases; C066690:RHOC protein, human; C508705:RND3 protein, human; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein; D020743:rhoB GTP-Binding Protein; D000075024:rhoC GTP-Binding Protein