Benzo[α]pyrene-induced anti-depressive-like behaviour in adult female mice: role of monoaminergic systems.
Benzo[α]pyrene (B[α]P) is a ubiquitous environmental pollutant exhibiting adverse effects on cognitive function and behaviour. In this study, depressive or antidepressive effects of B[α]P were investigated. Here, we report that a subacute B[α]P oral exposure (0.02-0.2 mg/kg) increases mobility behaviour in female adult mice in the tail suspension test, but not in the forced swimming test, without altering locomotion, suggesting that the tail suspension test was a more sensitive indicator of B[α]P-induced neurobehavioural disturbance. This might be because of differences in neurochemical substrates and pathways, mediating the performance in these behavioural models of depression. The effect of B[α]P on female adult mice in the tail suspension test was similar to that obtained with subacute treatment of the antidepressant reference drug imipramine (10 mg/kg). Therefore, B[α]P at 0.02 mg/kg and 0.2 mg/kg induces an antidepressant-like effect in mice, suggesting a neurobehavioural disturbance after oral exposure to this environmental compound. Furthermore, oral exposure to B[α]P at 0.02 mg/kg significantly increased gene expression levels of the brain receptors 5-hydroxytryptamine (serotonin) 1A (5HT(1A)) and alpha-1D adrenergic (ADRA(1D)). In summary, the presented findings suggest that subacute oral exposure to B[α]P results in behavioural changes in female adult mice, possibly caused by alterations in the serotoninergic and adrenergic systems.
Neurotoxicologie Alimentaire et Bioactivié, UR AFPA, Université de Lorraine-INRA, Metz, France. bouayedj@yahoo.fr
Jaouad
J
Bouayed
Torsten
T
Bohn
Elisabeth
E
Tybl
Alexandra K
AK
Kiemer
Rachid
R
Soulimani
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005786:Gene Expression Regulation; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D012737:Sex Factors
C547720:Adra1d protein, mouse; D000928:Antidepressive Agents; D012333:RNA, Messenger; D018340:Receptors, Adrenergic, alpha-1; D044282:Receptor, Serotonin, 5-HT1A; D001564:Benzo(a)pyrene