Serum sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) associates negatively with embryo quality in infertility patients.
OBJECTIVE
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a useful biomarker of infection and inflammation.


METHODS
We studied serum and follicular fluid sTREM-1 in infertile patients (N = 110) utilizing enzyme-linked immunosorbent assay.


RESULTS
Serum and follicular sTREM-1 were in good correlation (Pearson's correlation 0.56, P < 0.0001) with higher values in follicular fluid (140.4 ± 34.4 and 115.6 ± 35.1 pg/mL, t-test, P < 0.0001). Endometriosis associated with lower follicular and serum sTREM-1 compared with male factor infertility patients (age-adjusted r = -25.7 pg/mL, P = 0.018; r = -22.1 pg/mL, P = 0.030). No associations between follicular or serum sTREM-1 and clinical parameters were found, except higher serum sTREM-1 associated with lower embryo quality in all patients (adjusted r = -0.3%, P = 0.033), with a cutoff value between 111.5 and 113.3 pg/mL (OR = 0.38, P = 0.048; OR = 0.34, P = 0.028) predicting that more than 39% of embryos would be with good quality.


CONCLUSIONS
Serum sTREM-1 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia. kadri.haller-kikkatalo@ut.ee
Kadri
K
Haller-Kikkatalo
Aili
A
Sarapik
Gilbert C
GC
Faure
Marie-Christine
MC
Béné
Frédéric
F
Massin
Andres
A
Salumets
Raivo
R
Uibo
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004622:Embryo, Mammalian; D004715:Endometriosis / Q000097:blood; D005260:Female; D005298:Fertility; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D011237:Predictive Value of Tests; D011971:Receptors, Immunologic / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1