PEG coated biocompatible cadmium chalcogenide quantum dots for targeted imaging of cancer cells.
Cancer stands as a leading cause of mortality worldwide and diagnostics of cancer still faces drawbacks. Optical imaging of cancer would allow early diagnosis, evaluation of disease progression and therapy efficiency. To that aim, we have developed highly biocompatible PEG functionalized cadmium chalcogenide based three differently luminescent quantum dots (QDs) (CdS, CdSe and CdTe). Folate targeting scheme was utilized for targeting cancer cell line, MCF-7. We demonstrate the biocompatibility, specificity and efficiency of our nanotool in detection of cancer cells sparing normal cell lines with retained fluorescence of functionalized QDs as parental counterpart. This is the first time report of utilizing three differently fluorescent QDs and we have detailed about the internalization of these materials and time dependent saturation of targeting schemes. We present here the success of utilizing our biocompatible imaging tool for early diagnosis of cancer.
Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.
Aby Cheruvathoor
AC
Poulose
Srivani
S
Veeranarayanan
M Sheikh
MS
Mohamed
Sreejith
S
Raveendran
Yutaka
Y
Nagaoka
Yasuhiko
Y
Yoshida
Toru
T
Maekawa
D Sakthi
DS
Kumar
D002104:Cadmium / Q000737:chemistry*; D049109:Cell Proliferation; D018011:Chalcogens / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D049408:Luminescent Agents / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D045663:Quantum Dots; D013499:Surface Properties; D014407:Tumor Cells, Cultured
D018011:Chalcogens; D020099:Coated Materials, Biocompatible; D049408:Luminescent Agents; D002104:Cadmium; D011092:Polyethylene Glycols