Genetic variations in KIFC1 and the risk of aspirin exacerbated respiratory disease in a Korean population: an association analysis.
Modest effects of genes in various pathways are significant in the etiology of complex human diseases, including aspirin exacerbated respiratory disease (AERD). By functioning as a relevant component of respiratory processes, the human kinesin family member C1 (KIFC1) is hypothesized to play a role in AERD pathogenesis. A case-control analysis was carried out by comparing the genotype distribution of six KIFC1 single-nucleotide polymorphisms between 93 AERD cases and 96 aspirin-tolerant asthma controls in a Korean population. After controlling for confounds, logistic and regression models via various modes of genetic inheritance facilitated the association analysis. Initial results revealed significant association at 0.05 level of significance between several KIFC1 variations and AERD (P = 0.01-0.05, OR = 1.81-1.90) as well as fall rate of forced expiratory volume in the 1st second, an important diagnostic marker of airways constriction (P = 0.04-0.05). However, the signals were not deemed significant after multiple testing corrections (P                         (corr) > 0.05). Although the results do not support a major role of KIFC1 in AERD pathogenesis in a Korean asthma cohort, further replication and validation studies are required to clarify the current findings.
Department of Life Science, Sogang University, Seoul, 121-742, Republic of Korea.
Charisse Flerida A
CF
Pasaje
Joon Seol
JS
Bae
Byung-Lae
BL
Park
Jeong-Hyun
JH
Kim
Hyun Sub
HS
Cheong
Soo-Taek
ST
Uh
Choon-Sik
CS
Park
Hyoung Doo
HD
Shin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D055963:Asthma, Aspirin-Induced / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D019295:Computational Biology; D005260:Female; D005541:Forced Expiratory Volume / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020161:Physical Chromosome Mapping; D011014:Pneumonia / Q000150:complications / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D056910:Republic of Korea; D012307:Risk Factors; D055815:Young Adult; D028961:beta Karyopherins / Q000235:genetics*
C486566:KIFC1 protein, human; D028961:beta Karyopherins; D016547:Kinesins