Cross-cultural comparison of medicinal floras used against snakebites.
BACKGROUND
Envenomation causes an estimated 1.8-2.5 million incidences per year with a mortality level of 100-125,000 persons annually and more than 100,000 individuals suffer from severe complications, which may end in amputation of the attacked limb. The use of plants is a major part of the traditional practitioners' treatment of snakebites.


METHODS
A database was created for plants used to treat snakebites worldwide. From this database, we selected five countries with a high number of entries and representing different cultures, geography and floristic zones: Brazil, Nicaragua, Nepal, China and South Africa. The datasets were analysed by regression and binominal analysis to see if any family or genus used against snakebites was overrepresented in the respective traditional medicinal systems relative to the abundance in the local flora. The families from the different geographical areas were compared to ascertain whether the same plant families are preferred by different peoples.


RESULTS
Three 'hot' families (Apocynaceae, Lamiaceae and Rubiaceae) were recovered in at least two of the five compared countries in the regression analyses and one 'hot' family (Zingiberaceae) was recovered in two of the compared countries in the binomial analyses. Four out of five floras possess families identified as outliers in both regression and binomial analyses. Eight families were recovered by both the binomial and the regression analysis (40-62% of all highlighted families respectively). At the genus level, only Piper (Piperaceae) was recovered as a 'hot' genus in at least two floras. Seven genera were highlighted by both analyses (25-44% of the highlighted genera).


CONCLUSIONS
Cross-cultural comparison of medicinal floras used against snakebites appears to be useful for highlighting candidate families and genera for further studies.
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark. mmo@farma.ku.dk
Marianne
M
Molander
C Haris
CH
Saslis-Lagoudakis
Anna K
AK
Jäger
Nina
N
Rønsted
D029062:Apocynaceae; D001938:Brazil; D002681:China; D003431:Cross-Cultural Comparison; D006801:Humans; D019686:Lamiaceae; D019684:Magnoliopsida; D008519:Medicine, Traditional; D009390:Nepal; D009527:Nicaragua; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D019666:Rubiaceae; D012909:Snake Bites / Q000188:drug therapy*; D013019:South Africa; D030521:Zingiberaceae
D010936:Plant Extracts