Clinical features, prognostic factors, and their relationship with antiplatelet antibodies in children with immune thrombocytopenia.
We investigated and evaluated the demographics, clinical and laboratory features, treatment responses, and disease duration of 25 children with immune thrombocytopenia (ITP) eligible for detection of antiplatelet antibodies. We found that patients without antecedent of preceding infection (API) were more likely to have anti-GPIa/IIa than those with API (42.9% vs. 5.5%, P=0.048). Age groups of <2 years and 2 to 10 years were more likely to show response (R) or complete response (CR) to given treatments, whereas none of the patients whose onset age >10 years showed R or CR to given treatments (88.9% and 100% vs 0%, P=0.001). The percentage of newly diagnosed ITP was higher in age groups of <2 years (100%) and in 2 to 10 years (90%) than the age group of >10 years (16.7%, P=0.001). Patients without API (71.4%) were more likely to develop chronic ITP than those with API (5.6%, P=0.002). In conclusion, younger age was a favorable prognostic factor, especially in patients <2 years of age with respect to treatment responses and disease duration. In addition, API was associated with a short disease course as well as absence of anti-GPIa/IIa.
*Department of Pediatrics, Shin Kong Wu Ho-Su Memorial, Taipei City, Taiwan.
Wan-Ling
WL
Ho
Chin-Cheng
CC
Lee
Chiung-Ju
CJ
Chen
Meng-Yao
MY
Lu
Fu-Chang
FC
Hu
Shiann-Tarng
ST
Jou
Dong-Tsamn
DT
Lin
Kai-Hsin
KH
Lin
D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000276:immunology* / Q000628:therapy
D001323:Autoantibodies