[Molecular mechanisms for the improvement of wound healing ability of periodontal ligament in Marfan's syndrome].
Marfan's syndrome (MFS) is a systemic disorder of the connective tissues caused by insufficient fibrillin-1 microfibril formation and can cause cardiac complications, emphysema, ocular lens dislocation and severe periodontal disease. ADAMTSL6β, a microfibril-associated extracellular matrix protein that has been implicated in fibrillin-1 microfibril assembly is able to improve microfibril insufficiency in MFS mice model. These findings suggest a new therapeutic strategy for the treatment of MFS through ADAMTSL6β-mediated fibrillin-1 microfibril assembly. We here review effect on ADAMTSL6β to the improvement of microfibril insufficiency in periodontal tissue as a model.
Department of Biological Science and Technology, Tokyo University of Science, Japan.
Masahiro
M
Saito
Takashi
T
Tsuji
D000818:Animals; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D008382:Marfan Syndrome / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D051379:Mice; D020894:Microfibrils / Q000378:metabolism / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology; D058990:Molecular Targeted Therapy; D010513:Periodontal Ligament / Q000503:physiopathology*; D055503:Protein Multimerization; D012038:Regeneration; D014945:Wound Healing / Q000235:genetics*; D054392:Adipokines
D016326:Extracellular Matrix Proteins; D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; C000605722:FBN1 protein, human; D054392:Adipokines; C000605724:Fbn1 protein, mouse