Primary human hepatocyte transplantation in the therapy of hepatic failure: 2 cases report.
Liver failure is the end stage of hepatopathy with unfavorable prognosis. In two patients with liver failure, viable primary human hepatocytes, obtained from resected liver tissue of patients with hepatolithiasis, were transplanted into the spleen by interventional therapy through femoral arterial cannula. After transplantation, the patients' clinical symptoms and liver function were significantly improved. However, their bilirubin increased within six days following transplantation. One suffered from hepatic coma and give up treatment and the other patient died fourteen days after transplantation. It is technically safe to treat liver failure by intrasplenic transplantation of adult hepatocytes and the clinical efficacy has been confirmed. How to make transplanted hepatic cells proliferate and functionally survive is the key point to maintain continuous improvement of the recipient's hepatic function.
Department of Hepatobiliary Surgery, Hainan Provincial People's Hospital, Haikou, Hainan, China. ri2010sun@yahoo.cn
Zhuo-Ri
ZR
Li
Xian-Hai
XH
Mao
Xiao-Xuan
XX
Hu
Sheng-Dan
SD
Nie
Yong-Zhong
YZ
Shi
Hua
H
Xiang
Jian-Hui
JH
Yang
Ou-De
OD
Cao
D000328:Adult; D001663:Bilirubin / Q000378:metabolism*; D017809:Fatal Outcome; D006501:Hepatic Encephalopathy / Q000473:pathology*; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D017093:Liver Failure / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008111:Liver Function Tests; D008297:Male; D013154:Spleen / Q000473:pathology*; D017211:Treatment Failure
D001663:Bilirubin