[Extensive Dowling-Degos disease following long term PUVA therapy].
BACKGROUND
Dowling-Degos disease is a rare and benign inherited dermatosis.


METHODS
A 53-year-old woman presented with generalized histologically confirmed Dowling-Degos disease revealed 8 years after psoralen photochemotherapy (PUVA) for psoriasis. This presentation was special in terms of its considerable spread as well as the absence of comedone-like and punctate scars.


CONCLUSIONS
Dowling-Degos disease is a reticulate pigmentary disorder of the flexures associating prominent comedone-like lesions and pitted scars. Diagnosis is based on clinical and histopathological examination, which allows this entity to be differentiated from other reticulate pigmentary disorders. A literature review failed to provide any indication that PUVA therapy either aggravates or reveals Dowling-Degos disease, a finding which we feel merits mention.
Service de dermatologie, EPS La Rabta, Jabbari, Tunis, Tunisie. rymkort@yahoo.fr
R Kort
RK
Khaddar
W Koubaa
WK
Mahjoub
I
I
Zaraa
M Ben
MB
Sassi
A Ben
AB
Osman
A Chadli
AC
Debbiche
M
M
Mokni
D017255:Acitretin / Q000627:therapeutic use; D005799:Genes, Dominant; D006801:Humans; D053555:Keratin-5 / Q000235:genetics; D008548:Melanosis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D020460:Melanosomes / Q000473:pathology; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D019683:Penetrance; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects
C503940:KRT5 protein, human; D053555:Keratin-5; D017255:Acitretin