Connectable DNA logic gates: OR and XOR logics.
Modern computer processors are based on semiconductor logic gates connected to each other in complex circuits. This study contributes to the development of a new class of connectable logic gates made of DNA in which the transfer of oligonucleotide fragments as input/output signals occurs upon hybridization of DNA sequences. The DNA strands responsible for a logic function form associates containing immobile DNA four-way junction structures when the signal is high and dissociate into separate strands when the signal is low. A basic set of logic gates (NOT, AND, and OR) was designed. Two NOT gates, two AND gates, and an OR gate were connected in a network that corresponds to an XOR logic function. The design of the logic gates presented here may contribute to the development of the first biocompatible molecular computer.
Chemistry Department, University of Central Florida, 4000 Central Florida Blvd. Orlando, FL 32816-2366, USA.
Yulia V
YV
Gerasimova
Dmitry M
DM
Kolpashchikov
D001483:Base Sequence; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation
D004247:DNA