Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma.
We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders.
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Yu
Y
Miyazaki
Masaaki
M
Hirayama
Hirohisa
H
Watanabe
Noriyasu
N
Usami
Kohei
K
Yokoi
Osamu
O
Watanabe
Gen
G
Sobue
D004660:Encephalitis / Q000150:complications / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000175:diagnosis*; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications / Q000175:diagnosis*; D013945:Thymoma / Q000150:complications / Q000175:diagnosis*; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis*