Neuronal architectures with axo-dendritic polarity above silicon nanowires.
An approach is developped to gain control over the polarity of neuronal networks at the cellular level by physically constraining cell development by the use of micropatterns. It is demonstrated that the position and path of individual axons, the cell extension that propagates the neuron output signal, can be chosen with a success rate higher than 85%. This allows the design of small living computational blocks above silicon nanowires.
Institut Néel, Consortium de Recherches, pour l'Emergence des Technologies Avancées, CNRS et Université Joseph Fourier, BP 166, 38042 Grenoble Cedex 9, France.
Sophie
S
Roth
Ghislain
G
Bugnicourt
Mariano
M
Bisbal
Sylvie
S
Gory-Fauré
Jacques
J
Brocard
Catherine
C
Villard
D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D002478:Cells, Cultured; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods; D053770:Nanowires / Q000737:chemistry*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D012825:Silicon / Q000737:chemistry*
D012825:Silicon