Inhibition or enhancement by 4 Pacific Island food plants against cancers induced by 2 amino-3-methylimidazo[4,5-f]quinoline in male Fischer 344 rats.
A 1-yr carcinogenicity bioassay was conducted in rats fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), simultaneously with AIN-76/ high-fat (HF) diet alone, or with 10% starch replaced with kumara, pineapple, coconut, or taro, prepared as for a human diet. All of the non-IQ treated control, kumara, pineapple, or taro but not coconut-fed rats survived to 1 yr. None of the IQ-fed animals survived to 1 yr and although there were minor survival time differences among the groups, none was statistically significant. At sacrifice, IQ/HF controls had tumors in the skin, Zymbal's gland, ear canal, oral cavity, liver, and small intestine, totaling 32 among 20 animals. Kumara-fed rats had a similar tumor distribution but no tumors in the ear or oral cavity, and a total of 27 tumors among 20 animals, whereas pineapple-fed rats showed a somewhat lower tumor incidence (23/20 animals), including no small intestine lesions. Unexpectedly, a higher tumor incidence, especially of skin tumors, was seen in coconut and taro-fed animals (35/20 and 41/20 animals, respectively). In particular, the incidence of malignant liver tumors and gastrointestinal tumors were significantly increased in the taro-fed group in comparison with the kumara group.
The University of Auckland, Auckland, New Zealand. l.ferguson@auckland.ac.nz
Lynnette R
LR
Ferguson
Shuotun
S
Zhu
Dug Yeo
DY
Han
Philip J
PJ
Harris
D031230:Ananas / Q000737:chemistry; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D002273:Carcinogens / Q000008:administration & dosage*; D003059:Cocos / Q000737:chemistry; D031060:Colocasia / Q000737:chemistry; D004032:Diet / Q000208:ethnology; D005399:Fishes; D006358:Hot Temperature; D027723:Ipomoea batatas / Q000737:chemistry; D008297:Male; D008460:Meat / Q000032:analysis; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control*; D009520:New Zealand; D010139:Pacific Islands; D008517:Phytotherapy; D010945:Plants, Edible; D011804:Quinolines / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline