The use of pluripotent stem cell for personalized cell therapies against neurological disorders.
Although there are a number of weaknesses for clinical use, pluripotent stem cells are valuable sources for patient-specific cell therapies against various diseases. Backed-up by a huge number of basic researches, neuronal differentiation mechanism is well established and pluripotent stem cell therapies against neurological disorders are getting closer to clinical application. However, there are increasing needs for standardization of the sourcing pluripotent stem cells by establishing stem cell registries and banking. Global harmonization will accelerate practical use of personalized therapies using pluripotent stem cells.
Division of Intractable Diseases, Center for Biomedical Science, Korea National Institute of Health, Cheongwon-gun, Chungbuk 363-700, Republic of Korea.
Hye-Yeong
HY
Ha
Si-Hyong
SH
Jang
Ji-Won
JW
Jung
D002454:Cell Differentiation / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D009422:Nervous System Diseases / Q000473:pathology / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D033581:Stem Cell Transplantation