Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis.
The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis.
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, Republic of Korea.
SiHyun
S
Cho
Young Sik
YS
Choi
Young Eun
YE
Jeon
Kyung Jin
KJ
Im
Young Mi
YM
Choi
Su Youn
SY
Yim
HyeYeon
H
Kim
Seok Kyo
SK
Seo
Byung Seok
BS
Lee
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism*; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010537:Peritoneum / Q000737:chemistry*; D012333:RNA, Messenger / Q000032:analysis; D056910:Republic of Korea; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000235:genetics; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis* / Q000235:genetics; D055815:Young Adult
D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1