Inverse association of serum long-acting natriuretic peptide and bone mineral density in renal transplant recipients.
OBJECTIVE
Our aim was to evaluate the relationship between bone mineral density (BMD) and fasting serum long-acting natriuretic peptide (LANP) concentration in renal transplant recipients.


METHODS
Fasting blood samples were obtained from 65 renal transplant recipients. BMD was measured using dual energy X-ray absorptiometry in lumbar vertebrae (L2-L4). Serum LANP levels were measured using a commercial enzyme immunoassay kit.


RESULTS
Six patients (9.2%) had osteoporosis and 28 patients (43.1%) had osteopenia in renal transplant recipients. Increased serum LANP (p<0.001) was significantly correlated with low lumbar T-score cut-off points between groups (normal, osteopenia, and osteoporosis) in renal transplant recipients. Female patients had lower lumbar BMD than male renal transplant recipients (p=0.027). Univariate linear regression analysis indicated that lumbar BMD were positively correlated with height (p=0.038), body weight (p=0.003), and body mass index (BMI; p=0.019), whereas negatively correlated with LANP (p=0.004) among the renal transplant recipients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that body weight (R(2) change=0.132; p=0.006) and LANP (R(2) change=0.093; p=0.008) were the independent predictors of lumbar BMD values in the renal transplant recipients.


CONCLUSIONS
Serum LANP concentration correlates negatively with lumbar BMD values in renal transplant recipients.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Bang-Gee
BG
Hsu
Guan-Jin
GJ
Ho
Chung-Jen
CJ
Lee
Ying-Chin
YC
Yang
Yen-Cheng
YC
Chen
Ming-Hui
MH
Shih
Ming-Che
MC
Lee
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology; D010446:Peptide Fragments / Q000097:blood
D010446:Peptide Fragments; C054547:atrial natriuretic factor prohormone (1-30), human; D009320:Atrial Natriuretic Factor