Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
BACKGROUND
NAD(P)H:quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism is found to have a lower enzymatic activity, which may result in increased incidence of several kinds of carcinomas including colorectal cancer. Results from published studies on the association of NQO1 rs1800566 genetic polymorphism with the risk of colorectal cancer are inconsistent. We performed a meta-analysis to summarize the possible association.


METHODS
All eligible published studies were searched from PubMed and Elsevier ScienceDirect. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for additive, dominant, and recessive models to assess the association using fixed- or random-effect model.


RESULTS
We identified 12 case-control studies that include 5,525 cases and 6,272 controls for the present meta-analysis. Significant associations between NQO1 rs1800566 genetic polymorphism and risk of colorectal cancer were observed in additive (OR = 1.09, 95% CI = 1.02-1.16, p = 0.009) and dominant models (OR = 1.12, 95% CI = 1.04-1.21, p = 0.004 for TT + CT vs. CC). Moreover, in the subgroup analysis based on ethnicity, significant associations were observed in Caucasians but not in Asians.


CONCLUSIONS
This meta-analysis provided evidence that NQO1 rs1800566 genetic polymorphism was associated with increased risk of colorectal cancer and that the T allele probably acts as an important risk factor.
School of Public Health, Anhui Medical University, Meishan Road 81, 230032 Hefei, Anhui Province, China. kilthy11@yahoo.com
Rui
R
Ding
Shilei
S
Lin
Daojun
D
Chen
D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human