Exogenous normal lymph alleviating kidney injury by improving coagulation function in disseminated intravascular coagulation rats.
OBJECTIVE
To investigate the effect of exogenous normal lymph on kidney injury in disseminated intravascular coagulation (DIC) rats and to probe its mechanism.


METHODS
The DIC model was established by intravenous injection of Dextran 500. After 6 min, normal lymph without cell components was infused in the lymph group. After 40 min, the renal and coagulation function indices and renal histomorphology were observed.


RESULTS
Serum urea and creatinine in the model group were significantly higher than in the control and lymph groups. Renal morphological study showed red blood cell silting and casts forming in the model group. The prothrombin time (PT), prothrombin time ratio (PTR), activated partial thromboplastin time (APTT), and thrombin time of lymph and model groups were higher than those in the control group, whereas fibrinogen was lower. The PT, PTR, and APTT were prolonged in the lymph group than in the model group. The platelet functions of the lymph and model groups were higher than in the control group, but platelet aggregation rate and thrombosis-forming indices were lower than in the control group; the platelet adhesive and aggregation rates and thrombosis dry weight of the lymph group were lower than those of the model group.


CONCLUSIONS
Exogenous normal lymph could alleviate kidney injury in DIC rats, which may be related to the improving coagulation function.
Institute of Microcirculation, Hebei North University, Hebei Zhangjiakou, PR China.
Zi-Gang
ZG
Zhao
Chun-Yu
CY
Niu
Yu-Ping
YP
Zhang
Ya-Li
YL
Hou
Jun-Jie
JJ
Li
Hua
H
Jiang
D000818:Animals; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications*; D007262:Infusions, Intravenous; D007674:Kidney Diseases / Q000209:etiology* / Q000628:therapy*; D008196:Lymph; D051381:Rats; D017208:Rats, Wistar