The old and new methods of assessing kidney function.
Chronic kidney disease is a worldwide problem. Accurate assessment of kidney function is important for defining stages of kidney disease and assisting with drug dosing. Glomerular filtration rate (GFR) is a good index of the health of the kidney. Although measured GFR using an exogenous substance is the most accurate, it is difficult to obtain due to cost and resources. Equations calculating creatinine clearance and estimated GFR as a measure of kidney function have been developed using serum creatinine as a marker of kidney function. The Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration equations have been shown to have statistically significant differences in estimating GFR in various populations. Drug-dosing adjustments based on the various equations may differ. However, without clinical outcome data, it is yet to be determined whether these differences are clinically significant.
Division of Nephrology and Hypertension, Oregon State University and Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code CR9-4, Portland, OR 97201, USA.
Jessica L
JL
Steffl
William
W
Bennett
Ali J
AJ
Olyaei
D000375:Aging / Q000378:metabolism; D000465:Algorithms; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D010599:Pharmacokinetics
D003404:Creatinine