Inhibition of platelet activation and aggregation by furostanol saponins isolated from the bulbs of Allium macrostemon Bunge.
Three new furostanol saponins (FSs) were recently isolated from the dried bulbs of Allium macrostemon and were shown to have antiplatelet effects. This study investigated the inhibitory capabilities of these compounds on adenosine diphosphate (ADP)-induced human platelet activation. FS-1, when compared with the other 2, had a potent inhibitory effect on ADP-induced platelet aggregation and on the expression of P-selectin and integrin β-3. FS-1 also inhibited Ca mobilization and significantly decreased phosphorylated AKT expression in ADP-activated platelets. The suppression by FS-1 of ADP-induced platelet activation and aggregation shown in this study indicate its potential for therapeutic applications.
Department of Cardiology, Guangzhou Institute of Cardiovascular Diseases, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
Wen-Chao
WC
Ou
Hai-Feng
HF
Chen
Yun
Y
Zhong
Ben-Rong
BR
Liu
Shi-Ming
SM
Liu
Ke-Ji
KJ
Chen
D000244:Adenosine Diphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000490:Allium / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018517:Plant Roots; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D015398:Signal Transduction; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology*; D055815:Young Adult
D012503:Saponins; D013261:Sterols; C521858:furostanol saponin I; D000244:Adenosine Diphosphate