Acute kidney injury due to sodium bromate intoxication: a report of two cases.
Sodium bromate is a strong oxidant used as a neutralizing solution in hair permanents, as well as an auxiliary agent in printing and dyeing. Accidental or deliberate ingestion of bromate solution has rarely been reported in Korea. The clinical manifestations of bromate intoxication are vomiting, diarrhea, central nervous system symptoms, oliguric or non-oliguric acute kidney injury, hemolytic anemia, and deafness; most of these manifestations are reversible, with the exception of renal failure and deafness. Here, we report on two patients who demonstrated distinct clinical progressions. In the first case, a 16-year-old woman was successfully treated with hemodialysis and recovered renal function without hearing loss. However, in the second case, delayed hemodialysis resulted in persistent renal failure and hearing loss in a 77-year-old woman. This suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, as the rapid removal of bromate may be essential to preventing severe intoxication and its sequelae.
Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Korea.
Dong Hwan
DH
Ryu
Kyung Ae
KA
Jang
Seok Min
SM
Kim
Jong Won
JW
Park
Jun Young
JY
Do
Kyung Woo
KW
Yoon
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000293:Adolescent; D000368:Aged; D001959:Bromates / Q000633:toxicity*; D017809:Fatal Outcome; D005260:Female; D034381:Hearing Loss; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D006435:Renal Dialysis; D017670:Sodium Compounds / Q000633:toxicity*
D001959:Bromates; D017670:Sodium Compounds; C060553:sodium bromate