Whole genome scan identifies several chromosomal regions linked to equine sarcoids.
Despite the evidence for a genetic predisposition to develop equine sarcoids (ES), no whole genome scan for ES has been performed to date. The objective of this explorative study was to identify chromosome regions associated with ES. The studied population was comprised of two half-sibling sire families, involving a total of 222 horses. Twenty-six of these horses were affected with ES. All horses had been previously genotyped with 315 microsatellite markers. Quantitative trait locus (QTL) signals were suggested where the F statistic exceeded chromosome-wide significance at P < 0.05. The QTL analyses revealed significant signals reaching P < 0.05 on equine chromosome (ECA) 20, 23 and 25, suggesting a polygenic character for this trait. The candidate regions identified on ECA 20, 23 and 25 include genes regulating virus replication and host immune response. Further investigation of the chromosome regions associated with ES and of genes potentially responsible for the development of ES could form the basis for early identification of susceptible animals, breeding selection or the development of new therapeutic targets.
Equine Clinic, University of Berne. vendula.jandova@knp.unibe.ch
Vendula
V
Jandova
J
J
Klukowska-Rötzler
G
G
Dolf
J
J
Janda
P
P
Roosje
E
E
Marti
C
C
Koch
V
V
Gerber
J
J
Swinburne
D000818:Animals; D005260:Female; D055106:Genome-Wide Association Study / Q000662:veterinary*; D005838:Genotype; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D007889:Leiomyoma / Q000235:genetics / Q000662:veterinary*; D008297:Male; D018895:Microsatellite Repeats; D015995:Prevalence; D040641:Quantitative Trait Loci; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000235:genetics / Q000662:veterinary*