Preparation and characterization of mosapride citrate inclusion complexes with natural and synthetic cyclodextrins.
The aim of this work was to investigate the inclusion complexes between mosapride citrate and SBE7β-CD in comparison with the natural β-CD to enhance its bioavailability by improving the solubility and dissolution rate. The complexation efficiency value of SBE7β-CD was higher than that for β-CD. Solid binary systems of mosapride citrate with CDs were prepared by physical mixing, kneading and freeze-drying techniques at molar ratio of 1:1(drug:CD). Physicochemical characterization of the prepared systems was studied using X-ray diffractometry, differential scanning calorimetry, Fourier-transform infrared spectroscopy and scanning electron microscopy (SEM). Amorphous drug was detectable to large extent in inclusion complexes prepared using the freeze-drying technique. From the dissolution study of different inclusion complexes in simulated saliva solution (pH 6.8), we could concluded that irrespective of the preparation technique, the systems prepared using SBE7β-CD showed better performance than the corresponding ones prepared using β-CD. In addition, the freeze-drying technique showed superior dissolution enhancement than other methods especially when combined with the SBE7β-CD.
Department of Pharmaceutics and industrial pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt. dr_adelahmedali@yahoo.com
Adel A
AA
Ali
Ossama M
OM
Sayed
D001549:Benzamides / Q000737:chemistry*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005612:Freeze Drying / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009025:Morpholines / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry*
D001549:Benzamides; D009025:Morpholines; C103513:SBE7-beta-cyclodextrin; D047392:beta-Cyclodextrins; C062720:mosapride