Conjunctival amelanotic melanoma--a case report.
Conjunctival melanoma is a relatively rare malignancy. It is presented as pigmented nodule in any area of conjunctiva, amelanotic tumors are pink with smooth appearance. The authors describe an amelanotic melanoma of the conjunctiva in an 82-year-old female patient. Cytological, histopathological and immunohistochemical studies revealed an invasive amelanotic melanoma exhibiting S-100 and MART-1 positivity. The patient undervent surgical and chemotherapy treatment and three years after the initial treatment is in the terminal stage of metastatic disease. Absence of pigmentation delayed early clinical detection and treatment. Awareness of this nonpigmented melanoma is crucial for early recognition and appropriate management.
Department of Ophthalmology, Rijeka University Hospital Center, Rijeka, Croatia. damir.kovacevic@ri.t-com.hr
Damir
D
Kovacević
Koraljka
K
Lukanović-Primc
Vedran
V
Markusić
Marijana Bilen
MB
Babić
Darko
D
Ledić
D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D003230:Conjunctival Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D058965:MART-1 Antigen / Q000378:metabolism; D018328:Melanoma, Amelanotic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009418:S100 Proteins