Inducible clindamycin resistance in Staphylococcus aureus isolated from nursing and pharmacy students.
OBJECTIVE
Emergence of resistant isolates of Staphylococcus aureus (S. aureus) has resulted in failure of clindamycin therapy. The prevalence of inducible clindamycin resistance in S. aureus isolated from nursing students and pharmacy students (representing carriers exposed and not exposed to hospital environment respectively) was evaluated.


METHODS
Nasal, throat, and palmar swabs were collected from 119 nursing students and 100 pharmacy students. S. aureus was identified and antibiogram obtained by Clinical and Laboratory Standards Institute guidelines. Inducible clindamycin resistance was detected by the D-test.


RESULTS
36 and 34 individuals in the exposed and non-exposed groups respectively were carriers of S. aureus. 16.7% and 5.9% isolates showed inducible clindamycin resistance in exposed and non-exposed groups, respectively. The percentage of inducible clindamycin resistance was higher among methicillin-resistant S. aureus (MRSA) (27.8%) compared to methicillin-sensitive S. aureus (5.8%).


CONCLUSIONS
S. aureus isolates resistant to β-lactams can also show inducible clindamycin resistance. Exposure to hospital environment was not found to be a risk factor for carriage of S. aureus with MLSBi phenotype.
Department of Microbiology, Sri Siddharta Medical College, Tumkur, Karnataka, India. dr.renushree@gmail.com
Renushri
Avinandan
A
Saha
Nagaraj
Veena
V
Krishnamurthy