Regioselective synthesis of isocoumarins by ruthenium-catalyzed aerobic oxidative cyclization of aromatic acids with alkynes.
The highly regioselective aerobic oxidative cyclization of aromatic, heteroaromatic and alkenyl acids with alkynes in the presence of catalytic amounts of [{RuCl(2)(p-cymene)}(2)], AgSbF(6) and Cu(OAc)(2)·H(2)O providing isocoumarin derivatives was investigated.
Department of Chemistry, Indian Institute of Science Education and Research, Pune 411021, India.
Ravi Kiran
RK
Chinnagolla
Masilamani
M
Jeganmohan
D000143:Acids / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003500:Cyclization; D049934:Isocoumarins / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000143:Acids; D000480:Alkynes; D056831:Coordination Complexes; D049934:Isocoumarins; D012428:Ruthenium