Age-related changes in detection of spatial novelty.
Age-related changes in novelty detection for object-place associations was assessed in 6-mo and 25-mo-old Fisher 344/Brown Norway (F344/BN) rats. Old rats showed significant deficits compared to young rats in detecting spatial displacement of objects. The data suggest that object-place novelty detection is impaired in aged F344/BN rats using a rapidly acquired, exploratory-based task. The results may have important implications for the selection of efficient memory paradigms for future aging studies.
Department of Psychology, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182, United States.
David W
DW
Maasberg
Laura E
LE
Shelley
Paul E
PE
Gilbert
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology*; D006185:Habituation, Psychophysiologic; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D017603:Signal Detection, Psychological / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*