[Vitamin D and autoimmunity. First part: Fundamental aspects].
The effects of vitamin D on calcium homeostasis and bone metabolism are well known. In recent years, suboptimal vitamin D status has been recognized as a pandemic. Meanwhile, extra-skeletal effects of vitamin D are becoming better documented, particularly its effects on immunity. The authors present their actions on myeloid dendritic cells, T cells, B cells, as well as on the synthesis of antimicrobial peptides and autophagy, and the potential beneficial effects in autoimmune and inflammatory diseases.
Service de médecine interne, université Versailles Saint-Quentin-en-Yvelines, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France. y.schoindre@hopital-foch.org
Y
Y
Schoindre
B
B
Terrier
J-E
JE
Kahn
D
D
Saadoun
J-C
JC
Souberbielle
O
O
Benveniste
Z
Z
Amoura
J-C
JC
Piette
P
P
Cacoub
N
N
Costedoat-Chalumeau
D000890:Anti-Infective Agents / Q000276:immunology; D023181:Antimicrobial Cationic Peptides / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome; D014807:Vitamin D / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D014807:Vitamin D; D002118:Calcium