MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia.
In the relatively short period of time since their discovery, microRNAs have been shown to control many important cellular functions such as cell differentiation, growth, proliferation and apoptosis. In addition, microRNAs have been demonstrated as key drivers of many malignancies and can function as either tumour suppressors or oncogenes. The haematopoietic system is not outside the realm of microRNA control with microRNAs controlling aspects of stem cell and progenitor self-renewal and differentiation, with many, if not all, haematological disorders associated with aberrant microRNA expression and function. In this review, we focus on the current understanding of microRNA control of haematopoiesis and detail the evidence for the contribution and clinical relevance of aberrant microRNA function to the characteristic block of differentiation in acute myeloid leukaemia.
Blood, Stem Cells and Cancer Research, St Vincent's Hospital Centre for Applied Medical Research, St Vincent's Hospital, Darlinghurst, NSW, Australia. c.palma@amr.org.au
Catalina A
CA
Palma
Elise J
EJ
Tonna
David F
DF
Ma
Mark A
MA
Lutherborrow
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D038042:Myelopoiesis / Q000502:physiology*
D035683:MicroRNAs