Cytotoxic cardenolides from the stems of Periploca forrestii.
Six new cardenolides, periforosides D-E (1-2), periforgenin C (3) and periforosides F-H (4-6), as well as 10 previously identified cardenolides (7-16) were isolated from the ethanol extract of the stems of Periploca forrestii. The structures of the new compounds were determined using extensive spectroscopic analyses including HRESI-MS, 1D and 2D NMR data. Evaluation of the cytotoxic activity of all the isolated compounds in five different human cancer cell lines indicated that compounds 2-6, 8, 9 and 12-16 have potent activity.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xian Nong Tan Street, Beijing 100050, PR China.
Yong
Y
Li
Yun-Bao
YB
Liu
Shi-Shan
SS
Yu
Xiao-Guang
XG
Chen
Xian-Fu
XF
Wu
Shuang-Gang
SG
Ma
Jing
J
Qu
You-Cai
YC
Hu
Jing
J
Liu
Hai-Ning
HN
Lv
D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031109:Periploca / Q000737:chemistry*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*
D002298:Cardenolides; D010840:Phytosterols; D000431:Ethanol; D004317:Doxorubicin