Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice.
In the current study, administration of poly I:C induced a deficit in contextual, but not auditory-cue, fear memory consolidation. This memory deficit coincided with a decrease in hippocampal and cortical BDNF mRNA expression. These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression.
Department of Psychology, Texas Christian University, Fort Worth, TX 76129, USA.
Dinko
D
Kranjac
Kristina A
KA
McLinden
Kyle M
KM
Koster
David L
DL
Kaldenbach
Michael J
MJ
Chumley
Gary W
GW
Boehm
D000704:Analysis of Variance; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D003213:Conditioning, Psychological / Q000187:drug effects*; D016207:Cytokines / Q000378:metabolism; D005239:Fear / Q000187:drug effects*; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced*; D051379:Mice; D008810:Mice, Inbred C57BL; D011070:Poly I-C / Q000009:adverse effects*; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D012333:RNA, Messenger; D011070:Poly I-C