Cognitive impairment in antiphospholipid syndrome: evidence from animal models.
Although antiphospholipid syndrome (APS) is a multisystem prothrombotic condition, its inflammatory nature has been increasingly recognized in recent years. Stroke and transitory ischemic attacks are the neurological manifestations included in APS criteria, however many other neurological involvements have been attributed to antiphospholipid antibodies (aPL), such as seizures, transverse myelitis, and cognitive impairment. In this article we will review evidence from animal model that explain the role of aPL in cognition.
Rheumatology Unit, Department of Medicine, Faculty of Medical Science-State University of Campinas, Campinas, Brazil. appenzellersimone@yahoo.com
Simone
S
Appenzeller
Aline Tamires
AT
Lapa
Caio Rodrigues
CR
Guirau
Jozélio Freire
JF
de Carvalho
Yehuda
Y
Shoenfeld
D000818:Animals; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000523:psychology; D003072:Cognition Disorders / Q000150:complications* / Q000523:psychology; D004195:Disease Models, Animal; D006801:Humans