Suppressive effects by leaves of the Dypsis lutescens palm on fat accumulation in 3T3-L1 cells and fat absorption in mice.
The methanol extract of Dypsis lutescens leaves showed inhibitory effects on lipase activity in vitro and on triglyceride accumulation in 3T3-L1 pre-adipocytes. Further experiments using the extract on mice demonstrated a suppressive effect on the postprandial elevation of blood triglyceride level and an anti-obesity effect on obese mice induced by a high-fat diet. D. lutescens will accordingly be useful for preventing obesity.
Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan. tskoyama@kaiyodai.ac.jp
Tomoyuki
T
Koyama
Mitsuyoshi
M
Miyata
Tomio
T
Nishimura
Kazunaga
K
Yazawa
D041721:3T3-L1 Cells; D000042:Absorption / Q000187:drug effects; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism*
D010936:Plant Extracts; D014280:Triglycerides