Qualitative structure residue relationship analysis in the determination of the maximum residue limit of veterinary drugs.
Aim of the present study was an attempt to find a correlation between physicochemical structure of veterinary drugs and the maximum residue limit (MRL) for muscle tissue of food producing animals. Direct correlation and analysis in quintile groups for 52 physicochemical parameters were performed. An internal validation using leave-one-out cross-validation was performed. In the quintile groups, there were 11 arithmetic expressions created for the limited group of individual parameters (13 from 52 analyzed), which showed a significant linear or quadratic correlation between the number of quintile group and the mean value of MRL within the quintile. The results obtained suggest that there is no direct correlation between individual physicochemical parameters and MRL value in muscle tissue; however, such correlation can be determined for arithmetic expressions created on the basis of several physicochemical parameters, using quintile group analysis.
Centre of Pharmacokinetics Research Filab, Ravimed Sp. z o.o., Polna 54, 05-119 Łajski, Poland. tomasz.grabowski@polpharma.com.pl
Tomasz
T
Grabowski
Jerzy Jan
JJ
Jaroszewski
Walerian
W
Piotrowski
Marcin
M
Feder
D000818:Animals; D003198:Computer Simulation; D004784:Environmental Monitoring / Q000379:methods*; D008956:Models, Chemical; D009132:Muscles / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D019155:Veterinary Drugs / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics
D019155:Veterinary Drugs