Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.
Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.
Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. jessica_lin@med.unc.edu
Jessica T
JT
Lin
Jonathan J
JJ
Juliano
Oksana
O
Kharabora
Rithy
R
Sem
Feng-Chang
FC
Lin
Sinuon
S
Muth
Didier
D
Ménard
Chansuda
C
Wongsrichanalai
William O
WO
Rogers
Steven R
SR
Meshnick
D014644:Genetic Variation; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D016780:Malaria, Vivax / Q000175:diagnosis / Q000469:parasitology* / Q000517:prevention & control; D020066:Merozoite Surface Protein 1 / Q000235:genetics*; D058889:Molecular Typing; D010966:Plasmodium vivax / Q000235:genetics*; D012008:Recurrence; D012680:Sensitivity and Specificity; D055815:Young Adult
D020066:Merozoite Surface Protein 1