[Hepatoprotective effect of thiophane in rats with experimental carbon tetrachloride-induced hepatitis].
A hepatoprotective effect of thiophan was studied on the model of carbon tetrachloride-induced hepatitis in rats. Therapeutic administration of thiophan repairs the antitoxic function of liver, normalizes cytolysis marker activity, and improves the synthetic function of liver and the carbohydrate and lipid metabolism. The hepatoprotective activity of thiophan is similar to effect of silimarin.
V I
VI
Smol'iakova
M B
MB
Plotnikov
G A
GA
Chernysheva
I S
IS
Ivanov
A E
AE
Prosenko
N V
NV
Kandalintseva
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D050260:Carbohydrate Metabolism / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008658:Inactivation, Metabolic; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000008:administration & dosage / Q000627:therapeutic use; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*; D014280:Triglycerides / Q000032:analysis
D000975:Antioxidants; D020011:Protective Agents; D012838:Silymarin; D013876:Thiophenes; D014280:Triglycerides; C045141:thiophane; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin