Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents.
A highly efficient method is reported for the asymmetric ring opening of oxabicyclic alkenes with organolithium reagents. Using a copper/chiral phosphoramidite complex together with a Lewis acid (BF(3)·OEt(2)), full selectivity for the anti isomer and excellent enantioselectivities were obtained for the ring opened products.
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Pieter H
PH
Bos
Alena
A
Rudolph
Manuel
M
Pérez
Martín
M
Fañanás-Mastral
Syuzanna R
SR
Harutyunyan
Ben L
BL
Feringa