Humanized mice as a preclinical tool for infectious disease and biomedical research.
Immunodeficient mice bearing an IL2rγ(null)  mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.
The Jackson Laboratory, Bar Harbor, Maine, USA. lenny.shultz@jax.org
Leonard D
LD
Shultz
Michael A
MA
Brehm
Sina
S
Bavari
Dale L
DL
Greiner
D000818:Animals; D003141:Communicable Diseases / Q000209:etiology*; D004195:Disease Models, Animal; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency / Q000235:genetics; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008822:Mice, Transgenic; D018448:Models, Immunological; D009369:Neoplasms / Q000628:therapy; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology; D044968:Regenerative Medicine; D013601:T-Lymphocytes / Q000276:immunology; D018183:Transplantation Chimera / Q000276:immunology
D006680:HLA Antigens; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; C501922:Sirpa protein, mouse; D011971:Receptors, Immunologic