Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.
A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(ii) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.
Department of Chemistry, Gebze Institute of Technology, P.O. Box 141, 41400 Gebze Kocaeli, Turkey.  ahsen@gyte.edu.tr fdumoulin@gyte.edu.tr.
Sinem
S
Tuncel
Jérémie
J
Fournier-dit-Chabert
Florian
F
Albrieux
Vefa
V
Ahsen
Sylvie
S
Ducki
Fabienne
F
Dumoulin
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry; D015195:Drug Design; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D017967:Zinc Compounds
D020533:Angiogenesis Inhibitors; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D002599:Chalcone