Acupuncture for migraine prophylaxis: a randomized controlled trial.
BACKGROUND
Acupuncture is commonly used to treat migraine. We assessed the efficacy of acupuncture at migraine-specific acupuncture points compared with other acupuncture points and sham acupuncture.


METHODS
We performed a multicentre, single-blind randomized controlled trial. In total, 480 patients with migraine were randomly assigned to one of four groups (Shaoyang-specific acupuncture, Shaoyang-nonspecific acupuncture, Yangming-specific acupuncture or sham acupuncture [control]). All groups received 20 treatments, which included electrical stimulation, over a period of four weeks. The primary outcome was the number of days with a migraine experienced during weeks 5-8 after randomization. Our secondary outcomes included the frequency of migraine attack, migraine intensity and migraine-specific quality of life.


RESULTS
Compared with patients in the control group, patients in the acupuncture groups reported fewer days with a migraine during weeks 5-8, however the differences between treatments were not significant (p > 0.05). There was a significant reduction in the number of days with a migraine during weeks 13-16 in all acupuncture groups compared with control (Shaoyang-specific acupuncture v. control: difference -1.06 [95% confidence interval (CI) -1.77 to -0.5], p = 0.003; Shaoyang-nonspecific acupuncture v. control: difference -1.22 [95% CI -1.92 to -0.52], p < 0.001; Yangming-specific acupuncture v. control: difference -0.91 [95% CI -1.61 to -0.21], p = 0.011). We found that there was a significant, but not clinically relevant, benefit for almost all secondary outcomes in the three acupuncture groups compared with the control group. We found no relevant differences between the three acupuncture groups.


CONCLUSIONS
Acupuncture tested appeared to have a clinically minor effect on migraine prophylaxis compared with sham acupuncture.


BACKGROUND
Clinicaltrials.gov NCT00599586.
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Ying
Y
Li
Hui
H
Zheng
Claudia M
CM
Witt
Stephanie
S
Roll
Shu-guang
SG
Yu
Jie
J
Yan
Guo-jie
GJ
Sun
Ling
L
Zhao
Wen-jing
WJ
Huang
Xiao-rong
XR
Chang
Hong-xing
HX
Zhang
De-jun
DJ
Wang
Lei
L
Lan
Ran
R
Zou
Fan-rong
FR
Liang
D015670:Acupuncture Therapy / Q000379:methods*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000517:prevention & control*; D010147:Pain Measurement; D011788:Quality of Life; D012189:Retrospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome