In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice.
BACKGROUND
Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.


METHODS
Male Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 underwent a sham operation. Seven days after the surgery, propofol was administered in vivo and ex vivo (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP) left ventricular end-diastolic pressure (LVEDP), and maximal rate for left ventricular pressure rise and decline (± dP/dtmax ) were measured to determine the influence of propofol on the cardiac function of rats.


RESULTS
Impaired basal cardiac function was observed in the isolated BDL hearts, whereas in vivo indices of basal cardiac function (LVESP and ± dP/dt) in vivo were significantly higher in rats that underwent BDL compared with controls. With low or intermediate concentrations of propofol, these indices of cardiac function were within the normal physiologic range in both groups, and responsiveness to propofol was unaffected by BDL. When the highest concentration of propofol was administrated, a significant decline in cardiac function was observed in the BDL group.


CONCLUSIONS
In rats that underwent BDL, basal cardiac performance was better in vivo and worse ex vivo compared with controls. Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice.
Department of Anesthesia, Putuo Hospital, Shanghai, China.
Hong-Mei
HM
Ren
Li-Qun
LQ
Yang
Zhi-Qiang
ZQ
Liu
Cai-Yang
CY
Chen
Chi-Wai
CW
Cheung
Kun-Ming
KM
Tao
Jian-Gang
JG
Song
Wu-Rong
WR
Chen
Wei-Feng
WF
Yu
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D006339:Heart Rate / Q000187:drug effects*; D041781:Jaundice, Obstructive / Q000150:complications*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017725:Ventricular Pressure / Q000187:drug effects*
D018686:Anesthetics, Intravenous; D015742:Propofol