Composition of human skin microbiota affects attractiveness to malaria mosquitoes.
The African malaria mosquito Anopheles gambiae sensu stricto continues to play an important role in malaria transmission, which is aggravated by its high degree of anthropophily, making it among the foremost vectors of this disease. In the current study we set out to unravel the strong association between this mosquito species and human beings, as it is determined by odorant cues derived from the human skin. Microbial communities on the skin play key roles in the production of human body odour. We demonstrate that the composition of the skin microbiota affects the degree of attractiveness of human beings to this mosquito species. Bacterial plate counts and 16S rRNA sequencing revealed that individuals that are highly attractive to An. gambiae s.s. have a significantly higher abundance, but lower diversity of bacteria on their skin than individuals that are poorly attractive. Bacterial genera that are correlated with the relative degree of attractiveness to mosquitoes were identified. The discovery of the connection between skin microbial populations and attractiveness to mosquitoes may lead to the development of new mosquito attractants and personalized methods for protection against vectors of malaria and other infectious diseases.
Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands. Niels.Verhulst@wur.nl
Niels O
NO
Verhulst
Yu Tong
YT
Qiu
Hans
H
Beijleveld
Chris
C
Maliepaard
Dan
D
Knights
Stefan
S
Schulz
Donna
D
Berg-Lyons
Christian L
CL
Lauber
Willem
W
Verduijn
Geert W
GW
Haasnoot
Roland
R
Mumm
Harro J
HJ
Bouwmeester
Frans H J
FH
Claas
Marcel
M
Dicke
Joop J A
JJ
van Loon
Willem
W
Takken
Rob
R
Knight
Renate C
RC
Smallegange
D000328:Adult; D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D001419:Bacteria / Q000235:genetics / Q000302:isolation & purification*; D015169:Colony Count, Microbial; D006801:Humans; D008297:Male; D008875:Middle Aged; D010961:Plasmodium / Q000502:physiology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012867:Skin / Q000382:microbiology*
D012336:RNA, Ribosomal, 16S