Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives.
Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.
Advanced Research Laboratory in Synthetic and Natural Product Chemistry, V. G. Vaze College, Mumbai University, Mulund (E), Mumbai-4000081, India.
Soni A
SA
Singh
Sujata V
SV
Bhat
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D010666:Phenylpropionates / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
D000890:Anti-Infective Agents; D010666:Phenylpropionates; C035253:3-phenylpropionic acid