Oxidative stress, genotoxicity and histopathology biomarker responses in mullet (Mugil cephalus) and sea bass (Dicentrarchus labrax) liver from Bizerte Lagoon (Tunisia).
The aim of the study was to evaluate the impact of environmental contaminants on oxidative stress, genotoxic and histopathologic biomarkers in liver of mullet (Mugil cephalus) and sea bass (Dicentrarchus labrax) collected from a polluted coastal lagoon (Bizerte Lagoon) in comparison to a reference site (the Mediterranean Sea). Antioxidant enzyme activities were lower in fish from the polluted site compared with fish from the reference site, suggesting deficiency of the antioxidant system to compensate for oxidative stress. DNA damage was higher in both fish species from the contaminated site indicating genotoxic effects. The liver histopathological analysis revealed alterations in fish from Bizerte Lagoon. Hepatocytes from both fish species featured extensive lipid-type vacuolation and membrane disruption. Results suggest that the selected biomarkers in both fish species are useful for the assessment of pollution impacts in coastal environments influenced by multiple pollution sources.
Laboratory of Environmental Analytical Chemistry (05/UR/12-03), University of Carthage, Faculty of Sciences, Bizerte, 7021 Zarzouna, Tunisia.
Walid
W
Ben Ameur
Joaquin
J
de Lapuente
Yassine
Y
El Megdiche
Badreddine
B
Barhoumi
Souad
S
Trabelsi
Lydia
L
Camps
Joan
J
Serret
David
D
Ramos-López
Javier
J
Gonzalez-Linares
Mohamed Ridha
MR
Driss
Miquel
M
Borràs
D000818:Animals; D001492:Bass / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis*; D004249:DNA Damage / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D023701:Smegmamorpha / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014416:Tunisia; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
D015415:Biomarkers; D014874:Water Pollutants, Chemical