Prospective study of severity assessment and management of acute medical admissions with skin and soft tissue infection.
BACKGROUND
Several severity scoring systems have been proposed for skin and soft tissue infections (SSTIs), but none has been tested prospectively.


METHODS
We prospectively enrolled adult, acute medical admissions with SSTI between April 2009 and June 2010. Severity was assessed using two proposed SSTI scoring systems, one based on a generic sepsis definition. Antimicrobial prescribing was compared with guideline recommendations.


RESULTS
We enrolled 79 patients. One of the scoring systems classified 47% into class I (no sepsis or comorbidity), 5% into class II (no sepsis, but comorbidity), 34% into class III [sepsis, but standardized early warning system (SEWS) <4], and 14% into class IV (sepsis with SEWS ≥ 4). The other system classified 39% as mild and 61% as moderate/severe. There were significant discrepancies between the two scoring systems. Using the worst clinical observations in the first 24 h, 19% of patients had more severe disease than was apparent on admission. Under-treatment of patients with sepsis occurred in 13% of patients according to admission observations, increasing to 22% according to the worst observations. Seventy-nine percent of patients with sepsis received antibiotics within 4 h of admission. This was associated with fewer adverse outcomes (P = 0.05).


CONCLUSIONS
There is significant room for improvement in the management of SSTIs presenting to acute medical units. The added value of specific SSTI severity scores over generic sepsis assessment requires validation in a larger prospective study. We have changed our antibiotics policy for SSTI to use generic sepsis scores, and we emphasize the need to reassess patients on the day of admission.
Quality, Safety and Informatics Research Group, Division of Population Health Sciences, Medical Research Institute, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, Scotland, UK. charismarwick@nhs.net
Charis
C
Marwick
Nikolas
N
Rae
Nicola
N
Irvine
Peter
P
Davey
D000328:Adult; D000368:Aged; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000175:diagnosis* / Q000473:pathology*; D012720:Severity of Illness Index; D017192:Skin Diseases, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D018461:Soft Tissue Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology