Styryl conjugated coumarin caged alcohol: efficient photorelease by either one-photon long wavelength or two-photon NIR excitation.
The synthesis and photorelease properties of a new phototrigger for alcohols are described. Compared to ester 4 caged by the reported [7-(diethylamino)coumarin-4-yl]methoxycarbonyl (DEACM) phototrigger, the caged ester 3 shows an efficient single-photon photolysis efficiency upon irradiation of long wavelength light (λ = 475 nm) and a stronger two-photon photolysis sensitivity with 800 nm laser light. Its promising properties and the efficient photorelease of adenosine make it very useful as a caging group for biological applications.
Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, PR China.
Chunyan
C
Bao
Guanshui
G
Fan
Qiuning
Q
Lin
Bo
B
Li
Shuiyu
S
Cheng
Qi
Q
Huang
Linyong
L
Zhu
D000438:Alcohols / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D010782:Photolysis; D017785:Photons
D000438:Alcohols; D003374:Coumarins; C030123:coumarin