Detecting brown adipose tissue activity with BOLD MRI in mice.
The recent discovery of active brown adipose tissue (BAT) in adult humans and the correlation found between the activity of this tissue and resting metabolic rate strongly suggest that this tissue may be implicated in the development of obesity in humans, as it is in rodents. Despite the possible physiological role of this tissue in the onset of human obesity, few noninvasive imaging techniques to detect BAT activity in humans exist. The scope of this work is to investigate the possibility of detecting BAT activity using blood-oxygen-level-dependent MRI. Our results show that the strong increase in oxygen consumption and consequent increase in blood deoxyhemoglobin levels following BAT activation lead to a well-localized signal drop in BAT. This strongly suggests the possibility to use blood-oxygen-level-dependent MRI for the noninvasive detection of BAT activity.
Chemistry Department, French Family Science Center, Duke University, Durham, North Carolina 27708-0346, USA.
Arjun
A
Khanna
Rosa T
RT
Branca
D002001:Adipose Tissue, Brown / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D005260:Female; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D010100:Oxygen