Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiers.
The concomitant addition of the histone deacetylase inhibitor and the DNA methyltransferase inhibitor to the culture medium of an entomopathogenic fungus, Isaria tenuipes, greatly enhanced its secondary metabolite production and led to the isolation of tenuipyrone (1), a novel polyketide with an unprecedented tetracyclic ring system bearing a spiroketal structural component, along with two known C(10)-polyketides, cephalosporolide B (2), which is a plausible biosynthetic precursor of 1, and cephalosporolide F (3).
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Sendai 980-8578, Japan. tasai@m.tohoku.ac.jp
Teigo
T
Asai
Yu-Ming
YM
Chung
Hiroaki
H
Sakurai
Tomoji
T
Ozeki
Fang-Rong
FR
Chang
Kouwa
K
Yamashita
Yoshiteru
Y
Oshima
D057890:Epigenomics; D006999:Hypocreales / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification
D011753:Pyrones; D013141:Spiro Compounds; C571399:tenuipyrone