Active conformation of seven-membered-ring benzolactams as new ACAT inhibitors: latent chirality at N5 in the 1,5-benzodiazepin-2-one nucleus.
School of Pharmaceutical Sciences, Teikyo University, 1091-1 Midori-ku, Sagamihara, Kanagawa 252-5195, Japan.
Hidetsugu
H
Tabata
Naoya
N
Wada
Yuko
Y
Takada
Jun
J
Nakagomi
Tomohiro
T
Miike
Hiroaki
H
Shirahase
Tetsuta
T
Oshitari
Hideyo
H
Takahashi
Hideaki
H
Natsugari
D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D008862:Microsomes, Liver / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D011817:Rabbits; D013237:Stereoisomerism; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
C418322:1,5-benzodiazepin-2-one; D001569:Benzodiazepines; D002785:Sterol O-Acyltransferase