Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia:  a case report.
We herein present the case of an acute monoblastic leukemia infant who relapsed with acute lymphoblastic leukemia (ALL). Complete remission was achieved after an acute myeloblastic leukemia-directed chemotherapy, but the patient relapsed with pro-B ALL. As he did not respond to acute myeloblastic leukemia-type reinduction therapy, he was switched to ALL-type chemotherapy, and a complete remission was achieved. Unrelated cord blood stem cell transplantation was performed, but he relapsed with pro-B ALL again. After he received ALL-type chemotherapy, he underwent another bone marrow transplant from his human leukocyte antigen mismatch mother, and has been free from recurrence for over 8 months.
Department of Pediatrics, Osaka Medical College, Takatsuki Japan. ped031@poh.osaka-med.ac.jp
Akiko
A
Inoue
Chihiro
C
Kawakami
Kimitaka
K
Takitani
Toshiyuki
T
Ikemoto
Hiroshi
H
Tamai
D000971:Antineoplastic Combined Chemotherapy Protocols; D019070:Cell Lineage; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000473:pathology* / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000473:pathology* / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology* / Q000628:therapy