Value of bone SPECT-CT to predict chronic pain relief after percutaneous vertebroplasty in vertebral fractures.
BACKGROUND
Longer life span has resulted in increased risk of vertebral osteoporotic fractures. Among minimally invasive procedures, percutaneous vertebroplasty (PV) has shown excellent results in the treatment of chronic vertebral pain. The role of preintervention bone single photon emission computed tomography-computed tomography (SPECT-CT) has not been clearly established for the management of these patients.


OBJECTIVE
To determine the value of bone SPECT-CT in patient selection, treatment planning, and prediction of response to PV. A comparison with magnetic resonance imaging (MRI) was also aimed.


METHODS
Prospective consecutive series.


METHODS
We studied the performance of bone SPECT-CT on 33 consecutive patients with chronic pain because of vertebral fracture intended for PV.


METHODS
Improvement of clinical status was based on comparison of preprocedure and postprocedure outcome measurements of pain, mobility, and analgesic use.


METHODS
Bone SPECT was done using a dual-detector variable-angle gamma camera coupled with a two-slice CT scanner (Symbia T2 System; Siemens, Munich, Germany). Magnetic resonance imaging was done using a magnet of 1.5 T (Giroscan System ACS NT Intera; Philips, Amsterdam, The Netherlands).


RESULTS
Of the 33 patients, 24 finally underwent PV. Positive SPECT-CT images predicted clinical improvement in 91% (21 of 23) of them. Agreement between SPECT-CT and MRI was 80% (20 of 25). Single photon emission computed tomography-computed tomography images showed an alternative cause of pain in some cases, such as new fractures or multiple coexisting fractures, persisting bone remodeling in a previous cemented vertebra, and facet or discal degenerative disease. Single photon emission computed tomography-computed tomography was mandatory in eight patients that could no receive MRI, all of whom improved after PV.


CONCLUSIONS
Positive bone SPECT-CT seems a good predictor of postprocedural response. It also adds valuable information as to the cause of back pain and facilitates complete patient evaluation in patients that can not receive MRI.
Department of Nuclear Medicine, Hospital Universitari Germans Trias i Pujol. Carretera del Canyet, Badalona, Barcelona, Spain. msola.germanstrias@gencat.net
Montserrat
M
Solá
Ricard
R
Pérez
Patricia
P
Cuadras
Rocío
R
Díaz
Susana
S
Holgado
Paloma
P
Puyalto
Miquel
M
Iborra
Manel
M
Fraile
D000368:Aged; D059350:Chronic Pain / Q000209:etiology / Q000601:surgery*; D002985:Clinical Protocols; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D010149:Postoperative Pain / Q000175:diagnosis*; D018579:Patient Selection; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D016103:Spinal Fractures / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D013131:Spine / Q000473:pathology; D013669:Technetium Tc 99m Medronate; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D054854:Vertebroplasty / Q000379:methods*
D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate