The effect of a P123 template in mesopores of mesocellular foam on the controlled-release of venlafaxine.
A series of mesocellular foams (MCFs)-based mesoporous silica nanospheres (DH-MCF-P123-n, (n=12, 2, 0.5)) were synthesized as controlled-release deliveries for a typical antidepressant drug, venlafaxine. The foams were 3-(2,3-dihydroxypropoxyl)propyl-grafted and the P123 template partially preserved. We studied the release profiles of venlafaxine-loaded DH-MCF-P123-n in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively, as well as their corresponding venlafaxine loading capacities. Appropriate amounts of P123 template preserved in mesopores showed an efficient synergetic effect on increasing venlafaxine loading capacity and controlled-release property. Up to 90.87% (mass fraction) of venlafaxine could be loaded into DH-MCF-P123-2. For this carrier, 36% of venlafaxine was released after 1h of incubation in SGF and 53% of venlafaxine was released after 12h in SIF. The mechanisms of the loading and releasing processes were tentatively described based on the release behaviors.
Key Laboratory for Advanced Materials, Department of Chemistry, East China University of Science and Technology, Shanghai, PR China.
Jing
J
Tang
Zijun
Z
Bian
Jun
J
Hu
Shouhong
S
Xu
Honglai
H
Liu
D018687:Antidepressive Agents, Second-Generation / Q000737:chemistry*; D003511:Cyclohexanols / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005750:Gastric Juice / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D020442:Poloxamer / Q000737:chemistry*; D033362:Powder Diffraction; D012822:Silicon Dioxide / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D000069470:Venlafaxine Hydrochloride; D014961:X-Ray Diffraction
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020442:Poloxamer; D012822:Silicon Dioxide; D000069470:Venlafaxine Hydrochloride