Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review.
BACKGROUND
Rotavirus is the leading cause of severe diarrhea in children worldwide. We systematically reviewed the burden of rotavirus gastroenteritis (RVGE) and distribution of rotavirus strains in Asia.


METHODS
We searched MEDLINE, EMBASE and the World Health Organization (WHO) website for the term "rotavirus" and the name of each country. We included studies that were conducted in children between 2000 and 2011 and that examined the epidemiology, health and/or economic burden of RVGE, and G and P-type distribution in Eastern, South East, Southern and Central Asia. Random effects models were used to pool the proportions of RVGE. We also estimated child mortality due to RVGE using the updated WHO and United Nations Children's Fund's mortality estimates in 2008.


RESULTS
The search identified 113 eligible articles. The incidence rates of rotavirus-related hospitalizations in children under 5 years of age ranged from 2.1 to 20.0 cases per 1000 children per year with the highest rates reported in Bangladesh, South Korea, Taiwan, Thailand, and Vietnam. Rotavirus accounted for 37.5% of year-round hospitalized gastroenteritis cases, with higher proportions reported in South East Asia. Rotavirus was associated with approximately 145,000 deaths every year in Asia, with the greatest numbers occurring in India, Pakistan, and Indonesia. The highest annual societal costs of treating RVGE were reported in China (US$365 million), followed by Japan (US$254 million) and India (US$41-72 million). A diversity of rotavirus G and P-types was observed across Asia and the distribution of strains differed by country and year. The most common strains were G1P[8] (23.6%), G2P[4] (11.8%), G3P[8] (18.9%), and G9P[8] (7.4%).


CONCLUSIONS
Rotavirus is associated with substantial hospitalizations and deaths among children and causes large healthcare expenditures throughout Asia. Safe and effective rotavirus vaccines could substantially reduce the burden of disease.
Temple University, School of Pharmacy, 3307N. Broad Street, Philadelphia, PA 19140, USA. kkawai8@gmail.com
Kosuke
K
Kawai
Megan A
MA
O'Brien
Michelle G
MG
Goveia
T Christopher
TC
Mast
Antoine C
AC
El Khoury
D000293:Adolescent; D001208:Asia / Q000453:epidemiology; D002648:Child; D046688:Child Mortality; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D005102:Health Expenditures; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007114:Immunization; D015994:Incidence; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012401:Rotavirus / Q000145:classification / Q000187:drug effects / Q000276:immunology; D012400:Rotavirus Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D022243:Rotavirus Vaccines
D022243:Rotavirus Vaccines