[Can we identify biomarkers in bipolar depression? From imaging to biology].
Biomarkers can be used to describe and quantify a biological process related to pathology or to the effect of a treatment. In bipolar depression, progresses in the fields of structural and functional imaging, but also in biological research help to identify such biomarkers. Results in structural imaging are heterogeneous. Using functional imaging, in bipolar depression we can identify an hyperactivity of limbic and striatal regions with a specific implication of the lateral part of the orbito-frontal cortex. Bipolar depression is also associated with a modification of neurotrophic factors and of factors involved in the inflammatory process. Modifications in circadian rhythms have also be described but their level of specificity have to be demonstrated. The identification of biomarkers for bipolar depression seems to be an interesting field, but it still remains in the domain of research.
Université Paris-Est, faculté de médecine, UMR-S 955, Créteil, F-94010, France. marion.leboyer@inserm.fr
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D015415:Biomarkers / Q000097:blood*; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology; D016207:Cytokines / Q000097:blood; D038524:Diffusion Magnetic Resonance Imaging; D004644:Emotions / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D012890:Sleep / Q000502:physiology
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines