[Family based association study of MMP-9 gene-1562C>T polymorphism in schizophrenia].
OBJECTIVE
MMP-9 is a candidate gene related to the neurodevelopment hypothesis of schizophrenia. The aim of this research was TDT analysis of polymorphism -1562C>T MMP-9 gene in schizophrenia.


METHODS
Research was carried out on 147 trios (patient and his/hers both healthy parents). Genetic material was isolated from leukocytes using the salting out method. Polymorphism was studied with PCR-RFLP, statistic analysis was made using transmission disquilibrium test by Haploview 4.2.


RESULTS
There was no significant association between analyzed polymorphism of MMP-9 (-1562 C>T) and schizophrenia.


CONCLUSIONS
Insignificant association doesn't exclude the possible contribution of MMP-9 to pathogenesis of schizophrenia. Further research is needed to be carried out on bigger groups and other populations.
Zakiad Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
Agata
A
Groszewska
Paweł
P
Kapelski
Maria
M
Skibińska
Joanna
J
Hauser
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D020780:Matrix Metalloproteinase 9