High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects.
An emerging role of IL-17 in the inflammatory response associated with pathogenesis of neurodegeneration has been recently suggested. However, though diet represents a key factor in the modulation of inflammatory processes, evidence is not currently available on the nutritional regulation of IL-17 in humans. In a double blind, randomized, placebo controlled, crossover study, we investigated the effect of High Fat Meal (HFM) on IL-17 circulating levels in presence of a placebo (HFM-P) or with a Fruit Juice Drink (HFM-FJD) composed of pineapple, blackcurrant and plum in fourteen healthy overweight humans. Fasting in the morning subjects ingested a test meal providing 1344 Kcal. Ingestion of HFM-P induced an inflammatory response mediated by TNF-α (p < 0.001), IL-6 (p < 0.001) and IL-17 (p < 0.01). Plasma IL-17 concentration significantly increased at 1 h (+2.6 ± 1.1 pg/ml), remaining high at 4 h (+2.98 ± 1.2 pg/ml), 6 h (+2.38 ± 0.6 pg/ml) and 8 h (+2.8 ± 0.9 pg/ml) (ANOVA for time-course p=0.009). When the HFM was consumed in the presence of the FJD a marked inhibition of IL-17 response to the HFM was observed (ANOVA between treatment p=0.037). We provided, for the first time, evidence on the role of diet in modulating IL-17 production in healthy overweight subjects.
Antioxidant Research Laboratory, INRAN Via Ardeatina 546, 00178 Rome, Italy.
Ilaria
I
Peluso
Anna
A
Raguzzini
Debora V
DV
Villano
Eleonora
E
Cesqui
Elisabetta
E
Toti
Giovina
G
Catasta
Mauro
M
Serafini
D000328:Adult; D000704:Analysis of Variance; D031230:Ananas / Q000737:chemistry; D001628:Beverages; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000209:etiology; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000378:metabolism*; D019518:Postprandial Period; D027861:Prunus / Q000737:chemistry; D031965:Ribes / Q000737:chemistry; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004041:Dietary Fats; D020381:Interleukin-17; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha