Amyloidosis of seminal vesicles; incidence and pathologic characteristics.
OBJECTIVE
Amyloidosis is a rare disease with various etiologies with extracellular amyloid protein depositions. At present, at least 26 distinctive amyloid forms have been detected with different clinical importance and treatment. They have characteristic staning fetaures with Congo red. Amyloid may be detected in 2-10% of prostates that have been removed because of hyperplasia or carcinoma. Amyloidosis of seminal vesicles is accepted as senil amyloidosis and it is not accompanied by systemic amyloidosis or clinical symptoms. This condition is the most common form of localized amyloidosis. In this study we aimed to investigate incidence and histologic characteristics of amyloidosis of seminal vesicles in radical prostatectomy materials of the patients whose prostate carcinomas were treated surgically.


METHODS
Amyloid depositions in seminal vesicles of 207 radical prostatectomy materials that prostates had been removed due to localized prostate carcinoma. Amyloid depositions were confirmed with Congo red staining and polarization microscope.


RESULTS
Amyloidosis of seminal vesicles was detected in 10 (4.8%) of cases. Mean age of the patients is 66.2 years. Amyloid depositions tend to be nodular and bilateral in subepithelial region of affected seminal vesicles. Amyloid depositions were not detected in blood vessels in seminal vesicles or prostate parenchyma.


CONCLUSIONS
Localized amyloidosis of seminal vesicles is not an unusual finding. amyloidosis of seminal vesicles incidence in Turkish patients included in this study and histopathologic characteristics of these patients are not different from the other studies. Systemic AA amyloidosis is the most common form of amyloidosis in our country. To be aware of amyloidosis of seminal vesicles is of importance in discrimination from the other forms of amyloidosis.
Department of Pathology, Ege University, Faculty of Medicine, İzmir, Turkey.
Asuman
A
Argon
Adnan
A
Sımşır
Banu
B
Sarsik
Burçin
B
Tuna
Kutsal
K
Yörükoğlu
Gülen Gül
GG
Nıflıoğlu
Sait
S
Sen
D000230:Adenocarcinoma / Q000150:complications; D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D015994:Incidence; D033162:Incidental Findings; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications; D012669:Seminal Vesicles / Q000473:pathology*