Placental chorangiosis: the association with oxidative stress and angiogenesis.
OBJECTIVE
Chorangiosis is considered to be strongly associated with fetal, maternal, and placental disorders, and has been found to be correlated with increased fetal morbidity and mortality. In this study, it is aimed to investigate the association of angiogenesis and oxidative stress with the pathogenesis of chorangiosis.


METHODS
Expressions of heat shock protein 70 (HSP70), vascular endothelial growth factor-A (VEGF-A) and basic fibroblast growth factor (b-FGF), which are investigated with avidin-biotin-peroxidase method in formalin-fixed, paraffin-embedded sections from placental tissues diagnosed as no chorangiosis (n = 18) and chorangiosis (n = 18), have been evaluated in a semiquantitative manner.


RESULTS
There were significant differences between chorangiosis and no chorangiosis cases with respect to birth weight, birth length, and Apgar scores (p < 0.001). Statistically significant (p < 0.001), diffuse and strong expressions with HSP70, VEGF-A and b-FGF were observed in the villous tissue of placental chorangiosis cases when compared with no chorangiosis cases.


CONCLUSIONS
The majority of the chorangiosis cases had an accompanying poor perinatal outcome, and also those with accompanying angiogenesis and increased oxidative stress demonstrated diffuse and strong expressions of HSP70, VEGF-A and b-FGF. The interaction of maternal, placental, and fetal factors with increased oxidative stress and angiogenesis may possibly contribute to this arising pathologic change.
Departments of Gynecology and Obstetrics, Zonguldak Karaelmas University, Kozlu, Zonguldak, Turkey. aykbar@yahoo.com
Aykut
A
Barut
Figen
F
Barut
Nilufer Onak
NO
Kandemir
Erol
E
Aktunc
Ilker
I
Arikan
Muge
M
Harma
Mehmet Ibrahim
MI
Harma
Banu Dogan
BD
Gun
D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000098:blood supply*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010922:Placenta Diseases / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult
D018840:HSP70 Heat-Shock Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2