Cocaine self-administration in rats: discrete trials procedures.
A discrete trials procedure involves splitting up a self-administration session so that there are multiple distinct trials and inter-trial-intervals. This schedule is well suited to be used over 24 h periods which allows insight into diurnal variability in self-administration behavior. DT is also well suited for investigations using pretreatments for increasing or decreasing both high and low probability behavior.
Neuroscience Program, Wake Forest University Health Sciences, Winston-Salem, NC, USA. cdobrin@wfubmc.edu
Carson V
CV
Dobrin
David C S
DC
Roberts
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004334:Drug Administration Schedule; D023421:Models, Animal; D051381:Rats; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012646:Self Administration / Q000379:methods; D019966:Substance-Related Disorders
D003042:Cocaine