Amplexicine, an antioxidant flavan-3-ol from Polygonum amplexicaule.
Bioassay guided fractionation of an ethanolic extract of Polygonum amplexicaule D. Don led to the isolation of amplexicine, a new flavan-3-ol (1), along with khellactone (2). The structure of the isolates was established by UV, IR, HRESI/MS and NMR, including 1D and 2D experiments. Compound 1 exhibited considerable antioxidant activity in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay.
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, USA. mtantry@olemiss.edu
Mudasir A
MA
Tantry
Aziz A
AA
Rahman
D000975:Antioxidants / Q000032:analysis*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D028502:Polygonum / Q000737:chemistry*
D000975:Antioxidants; D005419:Flavonoids; C569885:amplexicine; C404987:flavan-3-ol