Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose.
OBJECTIVE
Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose. The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose.


METHODS
A total of 28 elderly patients were enrolled into the vitamin D treatment group. The control group included 23 age-, sex- and body mass index-matched elderly participants. The vitamin D treatment group was treated with vitamin D(3) according to serum concentrations of 25(OH)D.


RESULTS
With supplementation, 96.0% of patients achieved a mean serum 25(OH)D concentration of 123.2 ± 59.9 nmol/L. After 4.7 ± 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P = 0.007, P = 0.007, P = 0.037, respectively). Vitamin D treatment significantly increased high-density lipoprotein cholesterol (P = 0.037), but did not cause statistically significant differences in other lipid parameters.


CONCLUSIONS
We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose.
Department of Internal Medicine, Division of Geriatrics, Gulhane Medical Faculty Training Hospital, Ankara, Turkey. inaharci@gata.edu.tr
Ilkin
I
Naharci
Ergun
E
Bozoglu
Necmettin
N
Kocak
Suat
S
Doganci
Huseyin
H
Doruk
Muhittin
M
Serdar
D000368:Aged; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism*; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000187:drug effects / Q000378:metabolism; D008297:Male; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014807:Vitamin D / Q000097:blood / Q000627:therapeutic use*
D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014807:Vitamin D