Systemic ornidazole as an adjunct to non-surgical periodontal therapy in the treatment of chronic periodontitis: a randomized, double-masked, placebo-controlled clinical trial.
BACKGROUND
The purpose of this clinical trial is to evaluate the adjunctive clinical effects of the systemic administration of ornidazole (ORN) in the full-mouth scaling and root planing (SRP) of individuals with moderate-to-advanced chronic periodontitis.


METHODS
Fifty-eight individuals presenting ≥12 teeth with probing depth (PD) ≥4 mm were selected. All participants were instructed on strict oral hygiene measures and were advised to use 0.2% chlorhexidine mouthwash for 1 week before being allocated to two groups. Thirty participants were randomly assigned to full-mouth SRP + placebo (control group), and 28 participants were assigned to full-mouth SRP + ORN (test group). The clinical outcomes evaluated were plaque index, gingival index, clinical attachment level (CAL), and PD.


RESULTS
Fifty participants could be evaluated by ≤6 months. At 6 months, the test group had greater mean reduction (2.84 mm) in PD compared to the control group (0.84 mm) (P <0.05), and there was also a greater mean CAL reduction (2.92 mm) in the test group compared to the control group (0.92 mm) (P <0.05).


CONCLUSIONS
The systemic use of ORN, when used in conjunction with initial periodontal treatment consisting of SRP in adults with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.
Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India. periodonticsgdcri@gmail.com
A R
AR
Pradeep
Nitish
N
Kalra
N
N
Priyanka
Ella
E
Khaneja
Savitha B
SB
Naik
Sonender P
SP
Singh
D000328:Adult; D016301:Alveolar Bone Loss / Q000628:therapy; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D009325:Nausea / Q000139:chemically induced; D009910:Oral Hygiene; D009950:Ornidazole / Q000009:adverse effects / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010919:Placebos; D016745:Root Planing / Q000379:methods*; D013651:Taste Disorders / Q000139:chemically induced; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; D009950:Ornidazole; D002710:Chlorhexidine