Anal sphincter electromyography in patients with newly diagnosed idiopathic parkinsonism.
OBJECTIVE
The differential diagnosis of patients with idiopathic parkinsonism is difficult, especially early in the course of the disease. External anal sphincter electromyography (EAS-EMG) has been reported to be of value in the differential diagnosis between Parkinson's disease (PD) and multiple system atrophy (MSA). Patients with MSA are reported to have pathological EAS-EMG and patients with PD are reported to have significantly less pathological EAS-EMG results. Comparisons between patients with parkinsonian disorders have usually been made many years into the disease, and thus it is largely unknown if the results of EAS-EMG can be used to distinguish the different diagnoses in the early phase of the disease.


METHODS
We investigated 148 newly diagnosed patients with idiopathic parkinsonism from a population-based incidence cohort (100 definite PD, 21 probable PD, 16 MSA, 11 progressive supranuclear palsy, and 40 controls) with EAS-EMG within 3 months of their first visit and, in the majority of patients, before start of treatment with dopaminergic drugs. The clinical diagnoses were made using established clinical diagnostic criteria after a median follow-up of 3 years.


RESULTS
All patient groups had more pathological EAS-EMG results than controls. No EAS-EMG differences were found between the patient groups, especially not between PD and MSA.


CONCLUSIONS
External anal sphincter electromyography examination cannot separate the different parkinsonian subgroups from each other in early course of the diseases.
Department of Pharmacology and Clinical Neuroscience, Epidemiology and Public Health Sciences, Umeå University, Umeå, Sweden.
J
J
Linder
R
R
Libelius
E
E
Nordh
B
B
Holmberg
H
H
Stenlund
L
L
Forsgren
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000473:pathology*; D015331:Cohort Studies; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000473:pathology; D009130:Muscle, Smooth / Q000503:physiopathology*; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging; D013223:Statistics as Topic; D013494:Supranuclear Palsy, Progressive / Q000473:pathology