[Study on Chinese herbs' volatile oil micro-emulsions by means of pseudo-ternary phase diagram].
OBJECTIVE
To optimize the formulation of Chinese herbs' volatile oil micro emulsion.


METHODS
Sreened the formulation of blank micro-emulsion and the formulation of micro-emulsion contained volatile oil by means of pseudo-ternary phase diagram.


RESULTS
System of isopropyl myristate, polyoxyethylene hydrogenated castor oil, absolute ethyl alcohol and water could formed the largest area of micro-emulsion. The optimal formulation of micro-emulsion contained volatile oil was: volatile oil consisted of 2.852%, isopropyl myristate 6.65%, polyoxyethylene hydrogenated castor oil 30.42%, absolute ethyl alcohol 7.605% and water 52.47%.


CONCLUSIONS
Using pseudo-ternary phase diagram to optimize the formulation of Chinese herbs' micro-emulsion is scientific and feasible. The volatile oil's solubility is also increased by made of oil-in-water type micro-emulsion and insured the stability.
Department of Pharmaceutics, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China. ymengmeng1980@163.com
Meng-Meng
MM
Yang
Yan
Y
Zhang
Xin-You
XY
Liu
Ting-Ting
TT
Zhang
Mei
M
Liu
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D009226:Myristates / Q000737:chemistry; D009822:Oils, Volatile / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D014867:Water / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D004655:Emulsions; D005079:Excipients; D009226:Myristates; D009822:Oils, Volatile; D012997:Solvents; D013501:Surface-Active Agents; D014867:Water; C008205:isopropyl myristate