[iPS cells in dentistry].
The discovery of the induced pluripotent stem (iPS) cell technology, which enables us to produce pluripotent stem cells by introducing a few genetic factors, commands considerable attention in the field of dentistry. These iPS cells may be of particular importance for developing innovative technologies to regenerate missing jaw bones and lost teeth, and there are expectations that several types of tissue stem cells and mucosal cells in the oral area can be used as an ideal iPS cell source. We previously reported that the gingiva, which is often resected during general dental treatments and treated as biomedical waste, is a promising source of iPS cells. In this review, the current trends in iPS cell research in dentistry are outlined, and future aspects of potential applications of the iPS cell technologies to dental treatments will be discussed.
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Japan.
Hiroshi
H
Egusa
D016301:Alveolar Bone Loss / Q000628:therapy; D000818:Animals; D003813:Dentistry / Q000379:methods* / Q000639:trends; D005881:Gingiva / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends