Self-fluorescence of chemically crosslinked MRI nanoprobes to enable multimodal imaging of therapeutic cells.
Old chemistry for novel materials: Self-fluorescent high-relaxivity T(2)-weighted magnetic resonance imaging (MRI) contrast agents are produced. They are a novel type of MR/optical dual-modality in vivo imaging nanoprobe using glutaraldehyde crosslinking chemistry, and they are used to label and monitor therapeutic cells both in vitro and in vivo.
Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, Republic of Korea.
Hyun Min
HM
Kim
Young-Woock
YW
Noh
Hye Sun
HS
Park
Mi Young
MY
Cho
Kwan Soo
KS
Hong
Hyunseung
H
Lee
Da Hye
DH
Shin
Jongeun
J
Kang
Moon-Hee
MH
Sung
Haryoung
H
Poo
Yong Taik
YT
Lim
D003287:Contrast Media / Q000737:chemistry*; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism; D003952:Diagnostic Imaging / Q000379:methods*; D005453:Fluorescence; D005976:Glutaral / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D003287:Contrast Media; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D005976:Glutaral