Genetics of hearing loss: where are we standing now?
Hearing loss (HL) is the most common sensory impairment and is caused by a broad range of inherited to environmental causes. Inherited HL consists 50-60% of all HL cases. The inherited form of HL is further classified to different categories. More than 300 syndromes and 40 genes have been identified to result in different levels of HL. Although several diagnostic or screening tests have been developed, yet there are controversies around their use.
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, 101 The City Drive South, Bldg 56, Suite 500, Rt 81, Orange, CA 92868, USA.
Hossein
H
Mahboubi
Sami
S
Dwabe
Matthew
M
Fradkin
Virginia
V
Kimonis
Hamid R
HR
Djalilian
D004781:Environmental Exposure / Q000009:adverse effects*; D018876:Environmental Illness / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005820:Genetic Testing / Q000379:methods*; D034381:Hearing Loss / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D010375:Pedigree; D013577:Syndrome