Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma.
OBJECTIVE
The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.


METHODS
We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC.


RESULTS
Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P (CD147) = 0.031; P (MMP-9) = 0.020) and overall survival (OS) (P (CD147) = 0.044; P (MMP-9) = 0.013).


CONCLUSIONS
CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, People's Republic of China.
Songlin
S
Piao
Shu
S
Zhao
Fulin
F
Guo
Jie
J
Xue
Guodong
G
Yao
Zhili
Z
Wei
Qi
Q
Huang
Yao
Y
Sun
Bin
B
Zhang
D000328:Adult; D000368:Aged; D051926:Basigin / Q000096:biosynthesis*; D044584:Carcinoma, Ductal / Q000378:metabolism / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000706:statistics & numerical data; D053208:Kaplan-Meier Estimate; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D018987:Salivary Ducts / Q000737:chemistry / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
D051926:Basigin; D020780:Matrix Metalloproteinase 9