Stem cells deployed for bone repair hijacked by T cells.
Mesenchymal stem cells (MSCs) are a promising source for bone regeneration. Recently, in Nature Medicine, Liu et al. (2011) reported that host lymphocytes secrete IFN-γ and TNF-α to initiate apoptosis of transplanted MSCs and that aspirin can alleviate these effects to improve bone repair.
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yufangshi@sibs.ac.cn
Yufang
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Lixin
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