TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms.
Transient receptor potential (TRP) receptors are ion channels that mediate pain and inflammation. We provide evidence for the distinct roles of TRPV1 and TRPA1 in arthritis.
BHF Centre of Cardiovascular Excellence and Section of Integrative Biomedicine, King's College London, London, United Kingdom. sue.brain@kcl.ac.uk
Susan D
SD
Brain
D000818:Animals; D001169:Arthritis, Experimental / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D010146:Pain / Q000503:physiopathology*; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse; D005620:Freund's Adjuvant