Terpenoids from root bark of Celastrus orbiculatus.
Phytochemical investigation of root bark of Celastrusorbiculatus afforded 10 terpenoids and eight known compounds. Their structures were established on the basis of spectroscopic and chemical methods. Celastrol and its dimers and adducts displayed moderate inhibitory activity against T cell proliferation. The reaction of celastrol under acidic conditions was undertaken, and a mechanism is presented, which may help towards modification of its structure and elucidation of the biogenetic routes to natural celastrol derivatives.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Jian
J
Wu
Yu
Y
Zhou
Luoyi
L
Wang
Jianping
J
Zuo
Weimin
W
Zhao
D031247:Celastrus / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D013729:Terpenes