[A case of perianal squamous cell carcinoma attaining a complete response over five years with chemoradiotherapy].
We report a case with perianal squamous cell carcinoma, which showed a complete response more than five years after chemoradiotherapy. A 69-year-old-man was introduced to our hospital for the diagnosis of squamous cell carcinoma [T3 (8.0 × 8.0 cm) N0M0, Stage II]. The patient was treated by chemoradiotherapy, which consisted of 5-FU 750 mg/m²/ day (continuous intravenously) on days 1-5 and 29-33, and mitomycin C 10 mg/m² on days 1 and 29 and radiation at 2 Gy/day for 5 days per week (total dose 60 Gy). The patient tolerated this treatment with no severe adverse effects. Tumor disappeared completely 1 month after this treatment with no adjuvant therapy. The patient has been alive with no sign of recurrence for 6 years.
Dept. of Gastrointestinal Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Shinya
S
Imada
Masayuki
M
Ohue
Shingo
S
Noura
Tatsushi
T
Shingai
Masaaki
M
Motoori
Kentarou
K
Kishi
Isao
I
Miyashiro
Kinji
K
Nishiyama
Masahiko
M
Yano
Osamu
O
Ishikawa
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil