IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis.
OBJECTIVE
The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.


METHODS
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.


RESULTS
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.


CONCLUSIONS
This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
Central Laboratory, the First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, People's Republic of China.
Lin
L
Cui
Jing
J
Jia
Chun-Fen
CF
Ma
Su-Yun
SY
Li
You-Ping
YP
Wang
Xiao-Min
XM
Guo
Qiang
Q
Li
Hai-Bin
HB
Yu
Wei-Hong
WH
Liu
Lin-Bo
LB
Gao
D000328:Adult; D017668:Age of Onset; D019943:Amino Acid Substitution; D001249:Asthma / Q000235:genetics*; D002648:Child; D056726:Genetic Association Studies; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D044465:White People
D018793:Interleukin-13