Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.
There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs.
Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott & White, Temple, Texas 76502, USA. Prockop@medicine.tamhsc.edu
Darwin J
DJ
Prockop
Joo Youn
JY
Oh
D053687:Adult Stem Cells / Q000276:immunology / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000502:physiology; D057170:Translational Research, Biomedical; D014945:Wound Healing