Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy.
Enteropathy-associated T-cell lymphoma (EATL) is a rare non-Hodgkin lymphoma frequently associated with celiac disease. We report a case of EATL complicating adult autoimmune enteropathy (AIE). Analysis of phenotype, rearrangements in T-cell receptor genes, and chromosome alterations by high-resolution comparative genomic hybridization identified features distinct from those described for types I and II EATL. Furthermore, EATL arose from a single T-cell clone that had been present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate. Emerging T-cell clones should be monitored in patients with AIE who receive long-term immunosuppressive therapy.
Université Paris Descartes, Paris, France. georgia.malamut@egp.aphp.fr
Georgia
G
Malamut
Virginie
V
Verkarre
Céline
C
Callens
Orianne
O
Colussi
Gabriel
G
Rahmi
Elizabeth
E
MacIntyre
Corinne
C
Haïoun
Bertrand
B
Meresse
Nicole
N
Brousse
Serge
S
Romana
Olivier
O
Hermine
Nadine
N
Cerf-Bensussan
Christophe
C
Cellier
D001706:Biopsy; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D055028:Comparative Genomic Hybridization; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D019672:Genes, T-Cell Receptor; D020022:Genetic Predisposition to Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D010641:Phenotype; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D007166:Immunosuppressive Agents