Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis.
A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati OH 45229, USA. riad.lutfi@cchmc.org
Riad
R
Lutfi
Jennifer
J
Huang
Hector R
HR
Wong
D000208:Acute Disease; D002648:Child; D016883:Diabetic Ketoacidosis / Q000150:complications*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology / Q000628:therapy*; D010195:Pancreatitis / Q000150:complications / Q000628:therapy*; D010956:Plasmapheresis