Application of a topical biomimetic electrical signaling technology to photo-aging: a randomized, double-blind, placebo-controlled trial of a galvanic zinc-copper complex.
BACKGROUND
The first signs of facial skin photo-aging often occur in the skin of the periorbital area and include sagging, loss of firmness and definition, and sallowness. Epidermal wounds have been shown to alter the trans-epithelial electrical potential creating an electric signal that directs cell migration in epithelial wound healing; this electric field declines sharply with age. A topical galvanic zinc-copper complex, which couples elemental zinc and copper to create a biomimetic electric field, has demonstrated anti-inflammatory activity and extracellular matrix improvement in vitro, including collagen and elastin production.


OBJECTIVE
To evaluate the efficacy and tolerability of a galvanic zinc-copper complex on photo-aging parameters in a randomized, double-blind, placebo-controlled clinical trial.


METHODS
In this eight-week study, women (40-65 years) with mild to moderate photo-aging were randomized to use placebo or 1 of 3 galvanic zinc-copper complex compositions (gel and activating moisturizer). Efficacy evaluations included clinical grading, specialized clinical imaging, and subject self-assessments performed at baseline, 15-30 minutes after product application and after 1, 2, 4, and 8 weeks. Tolerability was based on adverse events and clinical grading of irritation. Significance was set at P?0.05 versus baseline and between treatment groups.


RESULTS
The study was completed by 124 women. Compositions containing the galvanic zinc-copper complex showed statistically significant clinical improvements versus placebo and baseline rapidly (15-30 min) after application and through week 8. Clinical grading showed significant improvement versus placebo in skin radiance and under-eye dark circles 15-30 minutes after first application with continued improvement through week 8, and in overall photo-damage, fine lines, lifted appearance of the eyes, and under-eye wrinkles starting after two weeks and continuing through week 8. Test compositions were well tolerated.


CONCLUSIONS
This galvanic zinc-copper complex provided rapid and lasting improvements versus placebo in photo-aged skin, supporting its use in topical anti-aging formulations.
Johnson & Johnson Consumer Products Company, Skillman, NJ, USA.
Jeannette
J
Chantalat
Elizabeth
E
Bruning
Ying
Y
Sun
Jue-Chen
JC
Liu
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D040761:Biomimetic Materials / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects; D003300:Copper / Q000008:administration & dosage* / Q000737:chemistry; D004311:Double-Blind Method; D004338:Drug Combinations; D004574:Electromagnetic Fields; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D008875:Middle Aged; D015595:Skin Aging / Q000502:physiology / Q000528:radiation effects*; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage* / Q000737:chemistry
D004338:Drug Combinations; D003300:Copper; D015032:Zinc