Direct and indirect tasks on assessment of dose and time distributions and thresholds of acute radiation exposure.
Mathematical methods were developed to construct dose and time distributions and their associated risks and threshold values for lethal and non-lethal effects of acute radiation exposure to include mortality and incidence, prodromal vomiting, and agranulocytosis. A new distribution (T-model) was obtained to describe time parameters of acute radiation syndrome such as the latency period, time to onset of vomiting, and time to initiation of agranulocytosis. Based on the dose and time distributions, the parameter translation method was defined using an orthogonal regression, which allows one to solve for these distributions in the case of acute radiation exposure. The assessment of threshold doses was performed for some effects of acute radiation syndrome: for the latency period, ∼6-8 Gy absorbed dose and ∼0.7-0.9 h time to onset of vomiting; and for incidence (agranulocytosis), ∼2-3 Gy absorbed dose and ∼2-3 h time to onset of vomiting. The obtained new formula for assessment of radiation risk is applicable to the time parameters of acute radiation syndrome.
Southern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, 456780 Russian Federation.
S V
SV
Osovets
T V
TV
Azizova
R D
RD
Day
N
N
Wald
M B
MB
Moseeva
D054508:Acute Radiation Syndrome / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011829:Radiation Dosage; D012044:Regression Analysis; D013997:Time Factors