Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids.
ω-3 polyunsaturated fatty acids have been shown to play an important role in health. Enriched with ω-3 polyunsaturated fatty acids modulate expression of a number of genes with such broad functions as cell proliferation, growth and apoptosis and cell signaling and transduction, these effects, seem to regulate coronary artery disease, hypertension, atherosclerosis, psychiatric disorders and various cancer. In this context, fat-1 transgenic cattle was designed to convert ω-6 to ω-3 fatty acids could form an ideal model to study the effect of ω-3 fatty acids on the above functions. This study focuses on the total genomic difference of gene expression between fat-1 transgenic cattle and wild-type using cDNA microarrays, several genes were found to be overexpressed or suppressed in transgenic cattle relative to wild-type, these discrepancy genes related with lipid metabolism, immunity, inflammation nervous development and fertility.
Department of Animal Science, Tianjin Agriculture University, Tianjin 300384, China.
Tao
T
Guo
Xin F
XF
Liu
Xiang B
XB
Ding
Fei F
FF
Yang
Yong W
YW
Nie
Yu J
YJ
An
Hong
H
Guo
D000818:Animals; D030801:Animals, Genetically Modified; D029742:Caenorhabditis elegans Proteins / Q000096:biosynthesis / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D044943:Fatty Acid Desaturases / Q000096:biosynthesis / Q000235:genetics*; D015525:Fatty Acids, Omega-3 / Q000502:physiology*; D005298:Fertility / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007109:Immunity / Q000235:genetics; D007249:Inflammation / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D009420:Nervous System / Q000254:growth & development; D020411:Oligonucleotide Array Sequence Analysis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D015525:Fatty Acids, Omega-3; D011994:Recombinant Proteins; C466741:fat-1 protein, C elegans; D044943:Fatty Acid Desaturases