Overview of plant-derived vaccine antigens: Dengue virus.
This review highlights the advantages and current status of plant-derived vaccine development with special reference to the dengue virus. There are numerous problems involved in dengue vaccine development, and there is no vaccine against all four dengue serotypes. Dengue vaccine development using traditional approaches has not been satisfactory in terms of inducing neutralizing antibodies. Recently, these issues were addressed by showing a very good response to inducing neutralizing antibodies by plant-derived dengue vaccine antigens. This indicates the feasibility of using plant-derived vaccine antigens as a low-cost method to combat dengue and other infectious diseases. The application of new methods and strategies such as dendritic cell targeting in cancer therapy, severe acute respiratory syndrome, tuberculosis, human immune deficiency virus, and malaria might play an important role. These new methods are more efficient than traditional protocols. It is expected that in the near future, plant-derived vaccine antigens or antibodies will play an important role in the control of human infectious diseases.
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Ravindra B
RB
Malabadi
Advaita
A
Ganguly
Jaime A Teixeira da
JA
Silva
Archana
A
Parashar
Mavanur R
MR
Suresh
Hoon
H
Sunwoo
D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D052179:Antigens, Plant / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D000956:Antigens, Viral / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D003715:Dengue / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D053059:Dengue Vaccines / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D003716:Dengue Virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007114:Immunization; D030821:Plants, Genetically Modified / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D057134:Antibodies, Neutralizing; D052179:Antigens, Plant; D000956:Antigens, Viral; D053059:Dengue Vaccines