Pyrolytic carbon coating for cytocompatibility of titanium oxide nanoparticles: a promising candidate for medical applications.
Nanoparticles for biomedical use must be cytocompatible with the biological environment that they are exposed to. Current research has focused on the surface functionalization of nanoparticles by using proteins, polymers, thiols and other organic compounds. Here we show that inorganic nanoparticles such as titanium oxide can be coated by pyrolytic carbon (PyC) and that the coating has cytocompatible properties. Pyrolization and condensation of methane formed a thin layer of pyrolytic carbon on the titanium oxide core. The formation of the PyC shell retards coalescence and sintering of the ceramic phase. Our MTT assay shows that the PyC-coated particles are cytocompatible at employed doses.
Department of Materials Science and Engineering, Sharif University of Technology, Iran.
Shahed
S
Behzadi
Mohammad
M
Imani
Mohammad
M
Yousefi
Pietro
P
Galinetto
Abdolreza
A
Simchi
Houshang
H
Amiri
Pieter
P
Stroeve
Morteza
M
Mahmoudi
D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D002244:Carbon / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D008697:Methane / Q000032:analysis; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013059:Spectrum Analysis, Raman; D013696:Temperature; D013818:Thermogravimetry; D014025:Titanium / Q000494:pharmacology*; D014961:X-Ray Diffraction
D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D002244:Carbon; D014025:Titanium; D008697:Methane