Role of uremic toxins and oxidative stress in the development of chronic kidney disease-mineral and bone disorder.
The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as "Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)." Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD-MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD-MBD.
Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Hisae
H
Tanaka
Hirotaka
H
Komaba
Masahiro
M
Koizumi
Takatoshi
T
Kakuta
Masafumi
M
Fukagawa
D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood / Q000502:physiology; D001847:Bone Diseases / Q000209:etiology*; D002614:Chelating Agents / Q000627:therapeutic use; D006706:Homeostasis; D006961:Hyperparathyroidism / Q000150:complications / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000628:therapy; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood / Q000502:physiology; D008903:Minerals / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010281:Parathyroid Hormone / Q000502:physiology; D011073:Polyamines / Q000627:therapeutic use; D006435:Renal Dialysis; D000069603:Sevelamer; D014511:Uremia / Q000378:metabolism*; D061205:Vascular Calcification / Q000209:etiology
D002614:Chelating Agents; D008903:Minerals; D010281:Parathyroid Hormone; D011073:Polyamines; D001120:Arginine; D000069603:Sevelamer; C062187:pentosidine; D008239:Lysine