[The effect of various levels of chitosan in rat diet on vitamins assimilation under their combined deficiency].
he effect of chitosan inclusion in the semi-synthetic diet of rats at a dose of 0,24 and 0,9% of dry weight on vitamin assimilation under combined moderate and deep deficiency has been studied. Four-week introduction of chitosan did not have a significant effect on levels of vitamins C, B1, B2 and A in the liver of animals, on vitamin B2 blood plasma concentration and thiamine and riboflavin urinary excretion regardless of the degree of vitamin deficiency intensity. The significantly decrease of vitamin E blood plasma concentration has been observed at high dose of chitosan in the diet under moderate vitamin deficiency, whereas under deep deficit such reduction has been detected even at a low dose. Thus, long-term chitosan inclusion in the diet under existing polyhypovitaminosis can lead to the deterioration of the sufficiency with fat-soluble vitamins.
O A
OA
Vrzhesinskaia
V M
VM
Kodentsova
N A
NA
Beketova
O V
OV
Kosheleva
O G
OG
Pereverzeva
D000818:Animals; D001361:Avitaminosis; D048271:Chitosan / Q000009:adverse effects* / Q000494:pharmacology*; D005526:Food, Formulated; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014815:Vitamins / Q000097:blood* / Q000652:urine*
D014815:Vitamins; D048271:Chitosan