Juvenile xanthogranuloma presenting as infiltrative conjunctival mass in an adult.
OBJECTIVE
To report on the clinical and histopathologic findings of a conjunctival juvenile xanthogranuloma in an adult.


METHODS
Case report and literature review.


RESULTS
A 43-year-old man developed 2 yellowish conjunctival lumps not associated with other ocular or systemic findings. A half-corneal diameter-sized main mass was located at the 2-o'clock position, and the other 1/8-corneal diameter-sized mass was located at the 4-o'clock position. The masses were vitelliform in appearance with poor supplying vessels. The masses were removed en bloc by conjunctivectomy. Cryotherapy was done along the excision margin. Histopathologic examination revealed dense infiltration by histiocytes with background of multiple lymphocytes and Touton giant cells. Immunohistochemical staining was positive for CD3 (T-cell marker) and CD68 (histiocytic marker) but negative for CD1a and S-100 (Langerhans cell marker).


CONCLUSIONS
Juvenile xanthogranuloma may present as conjunctival infiltrative masses in adults. Immunophenotyping is helpful in differentiating it from a more malignant lesion.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Kyoung Min
KM
Lee
Won Ryang
WR
Wee
Jin-hak
JH
Lee
Mee Kum
MK
Kim
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D003229:Conjunctival Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017679:Cryotherapy; D006801:Humans; D008297:Male; D013601:T-Lymphocytes; D014972:Xanthogranuloma, Juvenile / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D015415:Biomarkers; D017252:CD3 Complex; D051997:ADP-ribosyl Cyclase 1