An alternative synthetic route for an antidiabetic drug, rosiglitazone.
A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h.
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, Maharashtra, India.
Dhanaji V
DV
Jawale
Umesh R
UR
Pratap
Ramrao A
RA
Mane
D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000077154:Rosiglitazone; D013237:Stereoisomerism; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone