Uric acid, hyperuricemia and vascular diseases.
Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological reports have increasingly linked hyperuricemia with cardiovascular and neurological diseases. Studies highlighting the pathogenic mechanisms of uric acid point to an inflammatory response as the primary mechanism for inducing gout and possibly contributing to uric acid's vascular effects. Monosodium urate (MSU) crystals induce an inflammatory reaction, which are recognized by toll-like receptors (TLRs). These TLRs then activate NALP3 inflammasome. MSU also triggers neutrophil activation and further produces immune mediators, which lead to a proinflammatory response. In addition, soluble uric acid can also mediate the generation of free radicals and function as a pro-oxidant. This review summarizes the epidemiological studies of hyperuricemia and cardiovascular disease, takes a brief look at hyperuricemia and its role in neurological diseases, and highlights the studies of the advanced pathological mechanisms of uric acid and inflammation.
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Ming
M
Jin
Fan
F
Yang
Irene
I
Yang
Ying
Y
Yin
Jin Jun
JJ
Luo
Hong
H
Wang
Xiao-Feng
XF
Yang
D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism; D006073:Gout / Q000209:etiology / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism; D033461:Hyperuricemia / Q000150:complications / Q000378:metabolism*; D058847:Inflammasomes / Q000378:metabolism; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism; D020521:Stroke / Q000209:etiology / Q000378:metabolism; D014527:Uric Acid / Q000737:chemistry / Q000378:metabolism*; D014652:Vascular Diseases / Q000209:etiology / Q000378:metabolism*
D058847:Inflammasomes; D014527:Uric Acid