Diabetes mellitus in a cohort of patients with acromegaly.
OBJECTIVE
To evaluate the presence of diabetes mellitus (DM) in a cohort of patients with acromegaly.


METHODS
This was a cross sectional study.


RESULTS
Fifty-eight acromegalic patients were assessed. Only 29% met the criteria for cure, and 27% had the disease controlled. Twenty-two had DM; HbA1c was equal to 7.34 ± 2.2%. Most of the diabetic patients (18 out of 22, 82%) did not meet criteria for cure. They were more often hypertensive [16/22 (73%) vs. 17/36 (46%), p = 0.04], and used statins more frequently [14/22 (64%) vs. 8/36 (21%), p = 0.004]. After regression analysis, hypertension was associated with diabetes [odds ratio (OR): 9.28 (95% CI: 1.59 - 54.00), p = 0.01], and cured/ controlled acromegaly was associated with protection against the presence of diabetes [OR: 0.17 (95% CI: 0.03 - 0.78), p = 0.02].


CONCLUSIONS
The presence of DM was associated with active acromegaly and presence of hypertension. However, absolute levels of GH and IGF-1 did not differ between patients with and without diabetes.
Programa de Pós-Graduação em Ciências Médicas - Endocrinologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Ticiana Costa
TC
Rodrigues
Fabiola
F
Costenaro
Daniela
D
Fedrizzi
Marcelle D
MD
Oliveira
Paula B de
PB
Lima
Vitor
V
Boschi
Mauro Antônio
MA
Czepielewski
D000172:Acromegaly / Q000097:blood / Q000150:complications*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone