Metal complex derivatives of peptide nucleic acids (PNA).
Peptide nucleic acid (PNA) is a non-cyclic pseudopeptide-nucleic acid structural mimic with promising applications within diagnostics and drug discovery. This review focuses on metal complex derivatives of PNA. Metal ions and their complexes display unique physical and chemical properties and offer the opportunity to introduce new labels and probes for bioanalytical and diagnostic applications of PNA, but also to modulate or to introduce new (for example catalytic) functions and biological activities.
University of Heidelberg, Heidelberg, Germany. roland.kraemer@urz.uni-heidelberg.de
Roland
R
Krämer
Andriy
A
Mokhir
D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000737:chemistry*
D007477:Ions; D008670:Metals; D020135:Peptide Nucleic Acids; D004247:DNA