Equal volumes of undiluted nalbuphine and lidocaine and normal diluted saline prevents nalbuphine-induced injection pain.
OBJECTIVE
To determine if the intravenous co-administration of equal volumes of lidocaine and nalbuphine, with undiluted normal saline, prevents injection pain caused by nalbuphine.


METHODS
Eighty adult patients who were scheduled for minor surgeries under general anesthesia delivered via a laryngeal mask airway (LMA) were enrolled in this prospective, randomized, single-blind clinical trial. In the saline group (control) (n = 40), 1 mL (10 mg) nalbuphine was diluted with 9 mL normal saline. In the lidocaine group (experimental) (n = 40), 1 mL (10 mg) nalbuphine was diluted with 1 mL lidocaine (20 mg). The two respective nalbuphine solutions were injected into the cephalic vein at a rate of 20 mL/minute (0.33 mL/second). Pain scores were categorized into five grades. Pain responses upon intravenous injection of nalbuphine, site of cannulation, size of the catheter, and hemodynamic responses to nalbuphine were also recorded.


RESULTS
Overall, the median pain score of patients in the lidocaine group was lower than that of the saline group (p < 0.001). In addition, the incidence of injection pain was lower in the lidocaine group than the saline group (2.5% vs. 30%, p = 0.001).


CONCLUSIONS
A solution of equal volumes of lidocaine and nalbuphine can decrease intravenous nalbuphine-induced injection pain.
Department of Anesthesiology, Kaohsiung Medical University Hospital, Taiwan, ROC.
Fu-Yuan
FY
Wang
Ya-Chun
YC
Shen
Mao-Kai
MK
Chen
Siu-Wah
SW
Chau
Chia-Ling
CL
Ku
Yu-Tung
YT
Feng
Kuang-I
KI
Cheng
D000328:Adult; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009266:Nalbuphine / Q000008:administration & dosage*; D010146:Pain / Q000517:prevention & control*; D011446:Prospective Studies; D016037:Single-Blind Method
D008012:Lidocaine; D009266:Nalbuphine