Possible role of calcium permselectivity in bone adaptation.
According to the core activity of calcium in the bone cellular expression, a new hypothesis linking calcium transport with the mechanical loading is proposed to explain the mechano-adaptation of bone tissue. Due to the piezoelectric coupling, the tensile and compressive areas of bone produce different electrical environments for the osteocytic cells that are embedded in the lacuno-canalicular porosity. This electrical asymmetry engenders a calcium enrichment-exclusion effect that strongly changes the calcium concentration in the lacuno-canalicular fluid and thus modifies the remodelling process. A bibliographic body of evidence supporting this idea is given and its experimental validation is suggested.
Université Paris Est, Laboratoire Modélisation et Simulation Multi Échelle, MSME UMR CNRS 8208, 61 Avenue du Général de Gaulle, 94010 Créteil, France. thibault.lemaire@univ-paris-est.fr
Thibault
T
Lemaire
Salah
S
Naili
D000222:Adaptation, Physiological / Q000502:physiology*; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000737:chemistry* / Q000166:cytology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D004560:Electricity; D006801:Humans; D017136:Ion Transport / Q000502:physiology; D008954:Models, Biological; D010011:Osteocytes / Q000502:physiology*
D002118:Calcium