How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells.
How the Human T lymphotropic virus type 1 (HTLV-1) Tax protein stimulates proliferation while triggering cell cycle arrest and senescence remains puzzling. There is also a debate about the ability of Tax to activate or inhibit the DNA damage response. Here, we comment on these different activities and propose a conceptual rationale for the apparently conflicting observations.
National Fund for Scientific Research, Gembloux Agro-Bio Tech and Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège, Belgium.
Mathieu
M
Boxus
Luc
L
Willems
D002453:Cell Cycle; D049109:Cell Proliferation; D002470:Cell Survival; D004249:DNA Damage; D004260:DNA Repair; D016356:Gene Products, tax / Q000096:biosynthesis*; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D008954:Models, Biological
D016356:Gene Products, tax; C514970:tax protein, Human T-lymphotrophic virus 1