N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure.
Most studies report an association of the slow N-acetyltransferase 2 (NAT2) status with elevated bladder cancer risk. In this study, NAT2 genotypes and the decades-long records of Papanicolaou's grading of exfoliated urothelial cells in a former benzidine-exposed cohort of the Shanghai dyestuff industry (29 bladder cancer patients; 307 non-cancer cohort members, some of them presenting different grades of pre-malignant alterations of exfoliated urothelial cells) were investigated. The cohort members had been enrolled in regular medical surveillance since mid-1980s. No overall increase of slow NAT2 genotypes in the former benzidine-exposed bladder cancer patients was found, compared with non-diseased members of the same cohort. A lower presentation of the homozygous wild genotype NAT2 4/4 was observed in bladder cancer patients, compared with non-diseased members with averaged Papanicolaou's grading (APG)3 II (OR=0.31, 95 percent CI 0.10-0.96, p=0.034) or with APG less than II (OR=0.36,95 percent CI 0.12-1.10, p=0.063). Nevertheless, neither a protective influence of rapid NAT2 genotypes on bladder cancer risk nor on pre-malignant cytological alterations could be confirmed by the present data.
Shanghai Institutes for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Qing-wen
QW
Ma
Guo-fang
GF
Lin
Ji-gang
JG
Chen
Wei-Chao
WC
Guo
Yi-qiu
YQ
Qin
Klaus
K
Golka
Jian-hua
JH
Shen
D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D001560:Benzidines / Q000633:toxicity*; D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D019459:Urothelium / Q000187:drug effects* / Q000201:enzymology
D001560:Benzidines; C029876:benzidine; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human