Trigger release liposome systems: local and remote controlled delivery?
Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.
Medicines Research Unit, Aston University, Birmingham, B4 7ET, UK.
Sagida
S
Bibi
E
E
Lattmann
Afzal R
AR
Mohammed
Yvonne
Y
Perrie
D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008027:Light; D008081:Liposomes / Q000737:chemistry*; D008956:Models, Chemical; D054467:Phospholipases A2 / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D013696:Temperature; D010738:Type C Phospholipases / Q000008:administration & dosage*; D014465:Ultrasonics
D004337:Drug Carriers; D008081:Liposomes; D011355:Prodrugs; D054467:Phospholipases A2; D010738:Type C Phospholipases