Anaplastic oligodendroglioma with ganglioglioma-like maturation.
Neuronal differentiation of oligodendroglioma has been demonstrated by immunohistochemical and ultrastructural examinations in recent studies. However, oligodendrogliomas displaying a complete neurocytic morphology or even gangliocytic differentiation are rare. We describe a case of anaplastic oligodendroglioma that was characterized by the presence of ganglion cells in a 40-year-old-male. Histologically, the tumor was mainly composed of classical oligodendroglioma cells. The most exceptional finding of this tumor was the presence of ganglion cells and intermediate-sized ganglioid cells. Immunohistochemical analysis revealed that these cells were positive for Olig2 and negative for glial fibrillary acid protein (GFAP). Synaptophysin and microtubule-associated protein 2 (MAP2) were mainly detected in the ganglion cells. Fluorescence in situ hybridization analysis (FISH) revealed the deletion of the 1p and 19q chromosome arms in both the oligodendroglioma cells and ganglion cells. The R132H mutated isocitrate dehydrogenase 1 (IDH1) protein was detected by immunohistochemistry and direct DNA sequencing. The morphological, immunohistochemical, and genetic features of the tumor suggested a diagnosis of anaplastic oligodendroglioma, and this tumor was considered to be a rare form of oligodendroglioma displaying ganglioglioma-like maturation. FISH and mutant IDH1 examinations are useful diagnostic tools for the differential diagnosis of this tumor, i.e., ganglioglioma with anaplastic oligodendroglial features.
Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. ymurata@med.gunma-u.ac.jp
Yuko
Y
Tanaka
Sumihito
S
Nobusawa
Shinichi
S
Yagi
Hayato
H
Ikota
Hideaki
H
Yokoo
Yoichi
Y
Nakazato
D000328:Adult; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D002277:Carcinoma / Q000473:pathology* / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D018303:Ganglioglioma / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000378:metabolism; D000076104:Oligodendrocyte Transcription Factor 2; D009837:Oligodendroglioma / Q000473:pathology* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed
D051792:Basic Helix-Loop-Helix Proteins; D004273:DNA, Neoplasm; D005904:Glial Fibrillary Acidic Protein; D007521:Isocitrate Dehydrogenase; D019950:Mitogen-Activated Protein Kinase 1; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; C405708:OLIG2 protein, human