[Clinical analysis of multiple organ dysfunction syndrome caused by acute paraquat poisoning].
OBJECTIVE
To analysis clinical characteristics of the multiple organ dysfunction syndrome (MODS) caused by acute paraquat poisoning (APP).


METHODS
Clinical data of 68 APP cases from Jan 2006 to Jun 2009, including age, gender, poisoning time and dosage, and MODS time, were compared in two groups, i.e. the death (37 cases) and survived (31cases) groups. It was less than 24 hours from poisoning to rescue in all cases.


RESULTS
Among the 68 cases, the incident rate of ARDS was 51.47% (35 cases). The rate of acute lung injure was 97.1% (66 cases). The mortality was 54.4% (37 cases). There was no significant difference in age and gender between both groups (P > 0.05). The dosages and times from poisoning to rescue were significant different between two groups (P < 0.05, P < 0.01). In the death group, proportion of amounts (> 3) of organs related with MODS was 70.29%, which was significantly higher than that (38.71%) in survived group (P < 0.01). MODS and ALI/ARDS occurred in death group earlier than those in survival group (P < 0.05). On the other hand, cardiac, hepatic and renal damage occurred earlier than the lung injure.


CONCLUSIONS
MODS in APP patients occurred earlier, were more sever, and caused higher mortality. The poisoning dosage and time were important prognostic factors.
Emergency Department, The 12th Hospital of Guangzhou, Guangzhou 510620, China.
Jing
J
Shi
Yu-Feng
YF
Gao
Peng
P
Huang
Run-Sheng
RS
Zeng
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000175:diagnosis; D010269:Paraquat / Q000506:poisoning*; D011379:Prognosis; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000175:diagnosis; D012189:Retrospective Studies; D055815:Young Adult
D010269:Paraquat