Synthesis of α-indanones via intramolecular direct arylation with cyclopropanol-derived homoenolates.
A palladium-catalysed, tandem cyclopropanol rearrangement and direct arylation approach for the synthesis of 1-indanones is reported. The reaction is generally high yielding, uses oxygen as the terminal oxidant and tolerates a range of functional groups on the aryl ring.
Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, Canada M3J 1P3.
David
D
Rosa
Arturo
A
Orellana
D000475:Alkenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004988:Ethers, Cyclic / Q000737:chemistry*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry
D000475:Alkenes; D004988:Ethers, Cyclic; D007189:Indans; D007659:Ketones; C043657:cyclopropanol