Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
University of Gdansk, Gdansk, Poland.
Adam
A
Lesner
Anna
A
Łęgowska
Magdalena
M
Wysocka
Krzysztof
K
Rolka
D000595:Amino Acid Sequence; D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006368:Helianthus / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060327:Solid-Phase Synthesis Techniques; D013329:Structure-Activity Relationship
D010456:Peptides, Cyclic; C448501:SFTI-1 peptide, sunflower