Making enhancers from spare parts of the genome.
New studies show that novel long-range enhancers of developmental genes can emerge by exaptation of protein-coding sequences with no previous regulatory function.
Institute of Clinical Sciences, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London, UK.
David
D
Fredman
Xianjun
X
Dong
Boris
B
Lenhard
D000818:Animals; D005075:Biological Evolution; D017124:Conserved Sequence; D004742:Enhancer Elements, Genetic; D005091:Exons / Q000235:genetics; D020440:Gene Duplication; D050437:Genes, Developmental; D005809:Genes, Regulator; D016678:Genome; D006801:Humans; D051379:Mice; D012754:Sharks; D023701:Smegmamorpha