Long-term graft-versus-tumor effect following reduced intensity hematopoietic stem cell transplantation in a child with metastatic renal cell carcinoma.
Pediatric renal cell carcinoma (RCC) is rare and different from adult RCC. Although target agents have recently been introduced, allogeneic hematopoietic stem cell transplantation exploiting graft-versus-tumor effect still remains an important treatment option for metastatic RCC. A 2-year-old male with RCC developed hepatic metastases 6 months following radical nephrectomy and subsequent cytokine therapy. Allogeneic reduced-intensity stem cell transplantation (RIST) with early withdrawal of immunosuppression and delayed donor lymphocyte infusions was performed. A second transplantation was undertaken following marrow aplasia. Now he remains progression-free with regression of hepatic metastases 5.7 years after RIST, along with complete donor chimerism.
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea.
Hee Jo
HJ
Baek
Dong Kyun
DK
Han
Tai Ju
TJ
Hwang
Sul Hee
SH
Bae
Yoo Duk
YD
Choi
Hoon
H
Kook
D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D002675:Child, Preschool; D020350:Graft vs Tumor Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D018183:Transplantation Chimera