Metabolic evaluation of young women with congenital adrenal hyperplasia.
OBJECTIVE
To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage.


METHODS
We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH.


RESULTS
BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose.


CONCLUSIONS
Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.
Department of Pediatrics, Pediatric Endocrinology Unit, Center for Investigations in Pediatric, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.
Gabrielle Sormanti
GS
Schnaider-Rezek
Sofia Helena Valente de
SH
Lemos-Marini
Maria Tereza Matias
MT
Baptista
Gil
G
Guerra-Júnior
André Moreno
AM
Morcillo
Maricilda Palandi de
MP
Mello
Laurione Cândido de
LC
Oliveira
Lilia
L
D'Souza-Li
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D056128:Obesity, Abdominal / Q000175:diagnosis; D018709:Statistics, Nonparametric; D055105:Waist Circumference / Q000502:physiology; D055815:Young Adult
D001786:Blood Glucose; D005938:Glucocorticoids; D007328:Insulin; D008055:Lipids