Complete genome sequences of three Pseudomonas aeruginosa isolates with phenotypes of polymyxin B adaptation and inducible resistance.
Clinical "superbug" isolates of Pseudomonas aeruginosa were previously observed to be resistant to several antibiotics, including polymyxin B, and/or to have a distinct, reproducible adaptive polymyxin resistance phenotype, identified by observing "skipped" wells (appearance of extra turbid wells) during broth microdilution testing. Here we report the complete assembled draft genome sequences of three such polymyxin resistant P. aeruginosa strains (9BR, 19BR, and 213BR).
Institut de biologie intégrative et des systèmes, Université Laval, Québec, Canada.
Brian
B
Boyle
Lucia
L
Fernandez
Jerome
J
Laroche
Irena
I
Kukavica-Ibrulj
Caio M F
CM
Mendes
Robert W
RW
Hancock
Roger C
RC
Levesque
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010641:Phenotype; D011112:Polymyxin B / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*
D000900:Anti-Bacterial Agents; D011112:Polymyxin B