[The mammalian gonocytes fate: oogenesis or spermatogenesis].
Germ line cells become gonocytes after the completion of migration and colonization of gonadal anlages. After the contact with the somatic cells of genital ridges the reprogramming of gonocytes takes place. Upon entry the embryonic gonads germ cells undergo the most complete demethylation during germ line development, their chromatin tends to have an open conformation for a short period. This event promotes the susceptibility to meiosis-inducing factors signaling. The choice of the further path of gonocytes development just after the gonadal sex differentiation, mitotic arrest and meiotic entry are discussed. Analisis of the action mechanisms of meiosis-inducing and meiosis-preventing factors, especially retinoic acid and enzymes of its degradation and synthesis, was performed.
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D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D051525:Fibroblast Growth Factor 9 / Q000378:metabolism; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D006066:Gonads / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D006801:Humans; D008297:Male; D008322:Mammals; D008540:Meiosis / Q000502:physiology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009866:Oogenesis / Q000502:physiology*; D000072516:Retinoic Acid 4-Hydroxylase; D019849:Sex Determination Processes / Q000502:physiology*; D015398:Signal Transduction; D013091:Spermatogenesis / Q000502:physiology*; D014212:Tretinoin / Q000502:physiology*
D015415:Biomarkers; D051525:Fibroblast Growth Factor 9; D014212:Tretinoin; D003577:Cytochrome P-450 Enzyme System; D052247:Nitric Oxide Synthase Type II; D000072516:Retinoic Acid 4-Hydroxylase