Triphasic computed tomography (CT) scan in focal tumoral liver lesions.
OBJECTIVE
To assess the diagnostic accuracy of triphasic spiral CT in differentiating benign from malignant focal tumoral liver lesions.


METHODS
The study was conducted in Department of Radiology of Aga Khan University Hospital and Sind Institute of Urology and Transplantation, Karachi from Feb 2006 to Feb 2007. By convenient sampling, 45 patients found to have focal tumoral liver lesions were recruited for one year period and their triphasic CT scans findings were evaluated and later correlated with histopathology. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of triphasic CT scan were calculated.


RESULTS
Among 45 patients, 136 liver lesions (11 benign and 125 malignant) were detected with the help of different enhancement patterns. Out of these, 37(82.2%) patients had malignant while 8 (17.8%) had benign lesions. On later histopathological examination, 35 (77.8%) of the total 45 cases had malignant lesions while 10 (22.2%) were diagnosed as benign lesions. Based on these results, it could be assessed that triphasic CT Scan has a sensitivity of 100%, specificity of 80%, positive predictive value of 94.5%, negative predictive value of 100% and diagnostic accuracy of 95.5% in differentiating benign from malignant liver lesions.


CONCLUSIONS
Triphasic CT Scan is a good non-invasive tool in characterizing and differentiating benign from malignant liver lesions.
Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan.
Saima
S
Hafeez
Muhammad Shahbaz
MS
Alam
Zafar
Z
Sajjad
Zahid Anwar
ZA
Khan
Waseem
W
Akhter
Fatima
F
Mubarak
D000328:Adult; D000368:Aged; D001706:Biopsy; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media