Stem cell therapy for retinal diseases: update.
Distinct stem cell types have been established from embryos and identified in the fetal tissues and umbilical cord blood as well as in specific niches in many adult mammalian tissues and organs such as bone marrow, brain, skin, eyes, heart, kidneys, lungs, gastrointestinal tract, pancreas, liver, breast, ovaries, and prostate. All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases.
São Paulo University, Ribeirão Preto, São Paulo, Brazil. rubenssiqueira@terra.com.br
Rubens Camargo
RC
Siqueira
D001854:Bone Marrow Cells / Q000166:cytology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation; D042783:Endothelial Cells / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology; D044968:Regenerative Medicine; D012164:Retinal Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*