A new paradigm for stem cell therapy: substance-P as a stem cell-stimulating agent.
Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair is highly anticipated. In this report, we introduce a novel function of substance-P (SP), an 11-amino-acid peptide, as an injury-inducible messenger to mobilize bone marrow stem cells to the blood and finally to engage in tissue repair. This new drug may substitute for ex vivo cell culture of therapeutic cells by stimulating cell proliferation in the bone marrow in vivo and mobilizing those therapeutic cells to the patient's own blood stream. Again, the additional role of SP in mitigating inflammation-mediated tissue damage can further rationalize the clinical development of SP-peptide as a stem cell stimulant.
Department of Genetic Engineering, Kyung Hee University, Yongin, 146-701, Korea.
Hyun-Sook
HS
Hong
Do Yeon
DY
Kim
Kang Jun
KJ
Yoon
Youngsook
Y
Son
D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000187:drug effects* / Q000378:metabolism; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P