Cefixime-induced oculogyric crisis.
Oculogyric crisis is a neurologic adverse event characterized by bilateral dystonic, usually upward, conjugate eye deviations. Cefixime is a third-generation cephalosporin and is widely used in clinical practice in childhood. Confusion, encephalopathy, coma, myoclonus, nonconvulsive status epilepticus, and seizures have been described with the use of cephalosporins. We presented a cefixime-induced oculogyric crisis in a 7-year-old boy during the treatment of urinary tract infection, and this is the first case of cefixime-induced oculogyric crisis whose ocular symptoms gradually disappeared within 48 hours after the drug was discontinued.
Department of Pediatric Neurology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. dr.erhanbayram@yahoo.com
Erhan
E
Bayram
Meral Torun
MT
Bayram
Semra
S
Hiz
Mehmet
M
Turkmen
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D020682:Cefixime / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000494:pharmacology; D018756:GABA Antagonists / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D011183:Postoperative Complications / Q000188:drug therapy; D012008:Recurrence; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D018492:Dopamine Antagonists; D018756:GABA Antagonists; D020682:Cefixime