Humanized mice for the study of type 1 and type 2 diabetes.
The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.
University of Massachusetts Medical School, Worcester, Massachusetts, USA. dale.greiner@umassmed.edu
Dale L
DL
Greiner
Michael A
MA
Brehm
Vishnu
V
Hosur
David M
DM
Harlan
Alvin C
AC
Powers
Leonard D
LD
Shultz
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D004195:Disease Models, Animal; D006680:HLA Antigens / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency / Q000235:genetics; D016381:Islets of Langerhans Transplantation; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008822:Mice, Transgenic; D014183:Transplantation, Heterologous
D006680:HLA Antigens; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit