Influence of 1-D silica nanotubes as drug adsorbent on release behaviors of tulobuterol-loaded porous microcapsules.
Porous poly(ε-caprolactone) (PCL)/Eudragit RS 100 (ERS-100) microcapsules containing tulobuterol-adsorbed silica nanotubes (S-NTs) were prepared using a solvent evaporation method. The release behaviors of the PCL/ERS-100 microcapsules were investigated as a function of S-NT content. The PCL/ERS-100 microcapsules showed a stable and porous surface compared to the PCL microcapsules prepared without ERS-100. The drug loading and encapsulation efficiencies of the microcapsules were increased slightly by the addition of S-NTs due to the adsorption of the drugs on the S-NTs. In an acidic release medium, the PCL/ERS-100 microcapsules containing the tulobuterol-loaded S-NTs showed a slow drug release, which was dependent on the S-NT content. These behaviors are most likely due to the reduced diffusion rate of the drug from the hydrated microcapsules, which results from the strong interaction between the porous S-NTs and the drug.
Department of Chemistry, Inha University, Incheon, Republic of Korea.
Ki-Seok
KS
Kim
Soo-Jin
SJ
Park
D000180:Acrylic Resins / Q000737:chemistry; D000327:Adsorption / Q000187:drug effects; D002214:Capsules; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D016062:Porosity / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry*; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000494:pharmacology; D014961:X-Ray Diffraction
D000180:Acrylic Resins; D002214:Capsules; D004364:Pharmaceutical Preparations; D011091:Polyesters; C016240:polycaprolactone; C050528:Eudragit RS; C010809:tulobuterol; D012822:Silicon Dioxide; D013726:Terbutaline