Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae).
A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10(-5) M.
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. matropi@um.edu.my
Mat Ropi
MR
Muktar
Norfaizah
N
Osman
Khalijah
K
Awang
Hazrina
H
Hazni
Ahmad Kaleem
AK
Qureshi
A Hamid A
AH
Hadi
Kazuma
K
Zaima
Hiroshi
H
Morita
Marc
M
Litaudon
D000818:Animals; D001011:Aorta / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D026121:Indole Alkaloids; D014665:Vasodilator Agents; C571748:neonaucline