Knockout of 5-lipoxygenase results in age-dependent anxiety-like behavior in female mice.
BACKGROUND
The enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized.


RESULTS
Here we used the elevated plus maze behavioral paradigm to measure anxiety-like behavior in female mice lacking 5LO (5LO-KO) at three different ages. Adolescent 5LO-KO animals did not significantly differ from wild-type (WT) animals in anxiety-like behavior. However, adult and older mice exhibited increased anxiety-like behavior compared to WT controls.


CONCLUSIONS
These results indicate that 5LO plays a role in the development of the anxiety-like phenotype in an age-dependent manner in female mice. Future work should further investigate this interaction as 5LO may prove to be an important molecular target for the development of novel anxiolytic therapies.
Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.
Yash B
YB
Joshi
Domenico
D
Praticò
D000375:Aging / Q000473:pathology*; D000818:Animals; D001007:Anxiety / Q000201:enzymology*; D001094:Arachidonate 5-Lipoxygenase / Q000172:deficiency* / Q000378:metabolism; D001522:Behavior, Animal; D005260:Female; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
D001094:Arachidonate 5-Lipoxygenase