Rising rates of macrolide-resistant Mycoplasma pneumoniae in the central United States.
Macrolide-resistant Mycoplasma pneumoniae is widespread in Asia, and severe cases of pneumonia have been described in children. Little information is available about the resistance pattern in the United States. We collected respiratory samples from 49 patients with Mycoplasma infection in the central United States between 2007 and 2010. We found a macrolide resistance rate of 8.2%. Resistance should be considered when patients with M. pneumoniae infection do not have a satisfactory response to macrolides. Alternative antibiotics include tetracyclines or fluoroquinolones.
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. yamad@healthcare.uiowa.edu
Masaki
M
Yamada
Richard
R
Buller
Stephanie
S
Bledsoe
Gregory A
GA
Storch
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D024881:Drug Resistance, Bacterial; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000453:epidemiology* / Q000382:microbiology*; D015995:Prevalence; D014481:United States / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D018942:Macrolides