Mitigation of pyrexia by a Th-1-biased IgG subclass response after infection with equine herpesvirus type 1 in horses pre-immunized with inactivated vaccine.
The immunoglobulin G (IgG) subclass response was investigated in horses with or without pyrexia after natural infection with equine herpesvirus type 1 (EHV-1) in the field. All horses were kept at the training centers of the Japan Racing Association and were immunized with an inactivated EHV-1 vaccine before EHV-1 infection. An IgG subclass response dominated by IgGa and IgGb was induced in horses without pyrexia after EHV-1 infection. In contrast, horses that developed pyrexia showed increased IgGc and IgG (T) subclass production in addition to IgGa and IgGb. Although inactivated EHV-1 vaccines are considered to induce a mainly Th-2-biased response, these results indicated that the responses in horses inoculated with inactivated EHV-1 vaccine were not uniform, and that horses with a Th-1-biased response were likely to be protected from pyrexia.
Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan. bannai@epizoo.equinst.go.jp
Hiroshi
H
Bannai
Koji
K
Tsujimura
Takashi
T
Kondo
Manabu
M
Nemoto
Takashi
T
Yamanaka
Takeo
T
Sugiura
Tomohiro
T
Kato
Ken
K
Maeda
Tomio
T
Matsumura
D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005334:Fever / Q000209:etiology / Q000276:immunology*; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D006734:Horse Diseases / Q000276:immunology* / Q000821:virology*; D006736:Horses; D007074:Immunoglobulin G / Q000276:immunology*; D007564:Japan; D018417:Th1 Cells / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology
D007074:Immunoglobulin G; D015164:Vaccines, Inactivated