Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults.
OBJECTIVE
To evaluate the association between serum concentrations of complement factor-3 (C3) with anthropometric, biochemical, and lifestyle features in healthy young adults.


METHODS
From 157 young healthy adults 18 to 35 y old, anthropometric measurements and body composition, systolic and diastolic blood pressures, and lifestyle data were collected and analyzed. Blood samples were collected after a 12-h fast for the determination of glucose, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, insulin, C3, ceruloplasmin, and uric acid.


RESULTS
Complement factor-3 correlated directly with body mass index (r = 0.23417, P = 0.0032), body fat mass (bioelectrical impedance analysis; r = 0.33407, P < 0.0001), percentage of body fat (bioelectrical impedance analysis; r = 0.26873, P = 0.0007), waist circumference (r = 0.21266, P = 0.0075), insulin (r = 0.26152, P = 0.0009), homeostasis model assessment of insulin resistance (r = 0.24831, P = 0.0017), total cholesterol (r = 0.23335, P = 0.0033), triacylglycerols (r = 0.38435, P < 0.0001), and other outcome measurements. In the multiple linear regression analysis, triacylglycerols (r(2) = 0.1379, P < 0.0001) and body fat mass (bioelectrical impedance analysis; r(2) = 0.0621, P = 0.0010) were independently associated with the C3 concentration after adjusting for age, gender, smoking status, and physical activity.


CONCLUSIONS
Complement factor-3 seems to be related to several anthropometric and biochemical measurements in healthy young adults. These results demonstrate an independent role of triacylglycerols, a component of the metabolic syndrome, and body fat mass as possible predictors of C3 concentrations. Thus, C3 can be used as an early marker for metabolic syndrome manifestations.
Department of Clinical and Social Nutrition, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Brazil.
Ana Carolina Pinheiro
AC
Volp
Kiriaque Barra Ferreira
KB
Barbosa
Josefina
J
Bressan
D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D001938:Brazil; D002570:Ceruloplasmin / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003176:Complement C3 / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008019:Life Style; D008297:Male; D014280:Triglycerides / Q000097:blood*; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003176:Complement C3; D007328:Insulin; D014280:Triglycerides; D014527:Uric Acid; D002570:Ceruloplasmin