Changes at the nodal and perinodal axonal domains: a basis for multiple sclerosis pathology?
How axonal damage, a major prognostic factor of multiple sclerosis disability progression, is induced, is likely to be multifactorial. Whereas axonal injury has been identified as a consequence of myelin loss, the possibility of an additional direct damage is also suggested. In this context, recent data have highlighted the nodal and perinodal axonal domains of the myelinated neurons as potential targets of the disease process, opening new perspectives in multiple sclerosis pathophysiology.
CRICM-UPMC/Inserm UMR_S 975/CNRS UMR 7225, Hôpital de la Salpêtrière, Paris, France.
Anne
A
Desmazières
Nathalie
N
Sol-Foulon
Catherine
C
Lubetzki
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001369:Axons / Q000276:immunology / Q000473:pathology*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D009410:Nerve Degeneration / Q000276:immunology / Q000473:pathology*; D011901:Ranvier's Nodes / Q000276:immunology / Q000473:pathology*