Indication of liver transplantation for jaundice-free biliary atresia with portal hypertension.
BACKGROUND
At the present time, indications of liver transplantation (LT) for jaundice-free biliary atresia (BA) patients include intractable cholangitis, portal hypertension and pulmonary vascular disorders. However, the timing of LT remains unclear. In the current study, we describe the therapeutic strategies for jaundice-free BA patients.


METHODS
129 BA patients were undergone LDLT between May, 2001 and April, 2010 in the Department of Transplant Surgery, Jichi Medical University, Japan.


RESULTS
The indications of LDLT for jaundice-free BA patients was 30 patients (30/129, 23%), and included portal hypertension (16 patients, 53%). Among the 16 patients with portal hypertension, there were 7 patients (7/16, 23%) in which uncontrollable gastrointestinal bleeding was an indication of LDLT. There were 5 patients (5/7; 71%) in which bleeding sites were not identified, and 3 patients (3/7; 43%) in which supportive treatments against collateral vessels were performed as a previous treatment.


CONCLUSIONS
Even in jaundice-free BA patients, after supportive treatments for portal hypertension are performed, it is necessary to assess the esophageal and gastrointestinal varices regularly and to also prepare for LT simultaneously because there is a probability of the complication of uncontrollable gastrointestinal bleeding.
Department of Transplant Surgery, Jichi Medical University,3311-1 Yakushiji,Shimotsuke City, Tochigi, Japan. yuki371@jichi.ac.jp
Yukihiro
Y
Sanada
Koichi
K
Mizuta
Taizen
T
Urahashi
Yoshiyuki
Y
Ihara
Taiichi
T
Wakiya
Noriki
N
Okada
Naoya
N
Yamada
Satoshi
S
Egami
Kentaro
K
Ushijima
Shinya
S
Otomo
Koichi
K
Sakamoto
Yoshikazu
Y
Yasuda
Hideo
H
Kawarasaki
D000293:Adolescent; D001656:Biliary Atresia / Q000150:complications* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000601:surgery; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000601:surgery; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000601:surgery*; D007223:Infant; D007565:Jaundice / Q000150:complications; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods; D019520:Living Donors; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D055815:Young Adult