Extensive gingival and respiratory tract Kaposi sarcoma in a child after allogenic hematopoietic stem cell transplantation.
An 8-year-old, human immune virus-negative boy received full human leukocyte antigen-matched related allogenic hematopoietic stem cell transplantation (HSCT) for relapsed acute myeloid leukemia. While on cyclosporine A and prednisolone therapy for graft versus host disease, he developed extensive gingival, cutaneous, and respiratory tract human herpes virus-8-associated Kaposi sarcoma (KS). Withdrawal of cyclosporine, tapering of prednisolone, recovery of lymphocyte count, and local supportive measures resulted in resolution of his gingival and respiratory tract lesions. To our knowledge this is the first case of gingival and extensive respiratory tract KS to be reported in a child post HSCT.
King Saud Bin Abdulaziz University for Medical Science, Princess Noorah Oncology Centre, King Abdulaziz National Guard Medical City, Jeddah, Kingdom of Saudi Arabia. adilahabbas2000@yahoo.com.au
Adil A H
AA
Abbas
Wasil A
WA
Jastaniah
D002648:Child; D016572:Cyclosporine / Q000009:adverse effects; D005887:Gingival Neoplasms / Q000276:immunology*; D006086:Graft vs Host Disease / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D011239:Prednisolone / Q000009:adverse effects; D012514:Sarcoma, Kaposi / Q000276:immunology*; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone