Microdialysis: improving local chemotherapy in cancer using a mathematical model.
Although intratumoral chemotherapy administration has been evaluated in the past, its results have not been frequently comparable to those from systemic administration. We recently described microdialysis as a method for local chemotherapy administration with increasing effectiveness while reducing systemic toxicity. We present a mathematical model which supports the successful application of this procedure in optimizing the administered drug in different cases, using informatics tools and considering several parameters. We also review and discuss important aspects of cancer biology that should be taken into consideration in cancer chemotherapy, such as tumor heterogeneity, drug resistance and metastasis, and how this technique may be used to overcome any set-backs presented by these.
Gynaecological Department, University Hospital of Coimbra, Portugal. filipecorreiamartins@gmail.com
Filipe Correia
FC
Martins
Jose Luis
JL
Santos
Carlos Freire
CF
de Oliveira
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004333:Drug Administration Routes; D019008:Drug Resistance, Neoplasm; D006801:Humans; D017551:Microdialysis; D008962:Models, Theoretical; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents