Previable preterm rupture of membranes: gestational and neonatal outcomes.
BACKGROUND
Previable (less than 24 weeks) premature rupture of membranes complicates about 1 in every thousand births and is responsible for substantial perinatal mortality.


METHODS
In this paper, we retrospectively analyzed one twin and 35 singleton pregnancies.


RESULTS
Twenty cases occurred before and 16 after 20 weeks. Latency period ranged from 0 to 137 days, with an average of 35 days. Amniotic fluid index was reduced in 27 cases and normal in 6 cases. Expectant management was adopted in 31 cases (86%), five patients declined and opted for termination (14%) at admission or during the course of pregnancy. Steroids were prescribed for 12 patients at or after 24 weeks (39%), leukocyte count at admission varied from 6,000 to 16,200/mm(3), with an average of 11,310, in only 9% it was greater than 15,000, immature forms were present in 10 cases (28%). Clinical chorioamnionitis occurred in 71%, being three times more frequent in parous women. Bacteriuria was present in 2 of 30 cases (6.6%). Two women developed laboratorial and clinical signs of sepsis, none of them needed hysterectomy. There were no maternal deaths. Mean gestational age at delivery was 24 weeks, ranging from 16 to 39 weeks. In the expectant group, preterm delivery rate was 68%. There was one case of abruption. Cesarean rate was 31%. Neonatal mortality was 42% (8 cases). Overall neonatal survival was 35% (11 in 32 newborns).


CONCLUSIONS
Perinatal mortality is high in pregnancies complicated by previable rupture of membranes, however gestational age at occurrence is a strong predictor of outcome. An individualized approach is the best management option regarding maternal risks and fetal outcomes.
Department of Obstetrics and Gynecology, State University of Campinas, Campinas, Brazil.
Marcela Furlan
MF
Margato
Guilherme Lopes Pinheiro
GL
Martins
Renato
R
Passini Júnior
Marcelo Luís
ML
Nomura
D000328:Adult; D000653:Amniotic Fluid; D001437:Bacteriuria / Q000453:epidemiology; D002821:Chorioamnionitis / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007958:Leukocyte Count; D054238:Perinatal Mortality; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D018805:Sepsis / Q000453:epidemiology; D013256:Steroids / Q000627:therapeutic use; D055815:Young Adult
D013256:Steroids