Vulvar yolk sac tumor mixed with embryonal carcinoma in a peri-pubertal girl: a case report.
OBJECTIVE
Vulvar cancer is rare in Eastern females, especially in pre- and peripubertal girls. The prognosis of vulvar cancer is poor and treatment is variable.


METHODS
A 14-year-old girl suffered from a left vulvar tenderness mass and underwent excision of the mass. The diagnosis of the pathology was vulvar yolk tumor with an embryonal carcinoma. After the vulvectomy, inguinal area lymph node dissection, chemotherapy (bleomycin, etoposide and cisplatin) treatment and radiotherapy, metastasis to lung was also noted after eight months. Resection of lung tumor was performed. She received chemotherapy with a combination of paclitaxel, ifosphamide and cisplatin (TIP) and received peripheral blood stem cell transplantation (PBSCT) twice and chemotherapy treatment of gemitabine and oxaliplatin (GEMOX). Up until now, the patient has been free of disease.


CONCLUSIONS
High-dose TIP and GEMOX chemotherapy plus PBSCT for bone marrow rescues could be considered to treat patients with metastatic malignant vulvar germ cell tumor after failed first-line chemotherapy and radiation.
Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
Cherry
C
Yin-Yi Chang
Kang-Hsi
KH
Wu
Tze-Yi
TY
Lin
Wei-Chun
WC
Chang
Wu-Chou
WC
Lin
Yao-Ching
YC
Hung
Lian-Shung
LS
Yeh
D000293:Adolescent; D018236:Carcinoma, Embryonal / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy