The roles of neurotrophic factor and Wnt signaling in depression.
Depression is a debilitating disease with a lifetime prevalence of ~16% in the American population. In addition to the monoamine hypothesis, altered expressions of neurotrophic factors, growth factors, and Wnt signaling are implicated in the pathophysiology and treatment of depression. This review focuses on intracellular signaling cascades that underlie depression and treatment response.
Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA.
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000502:physiology; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013315:Stress, Psychological / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism* / Q000502:physiology
D000928:Antidepressive Agents; D009414:Nerve Growth Factors; D016194:Receptors, N-Methyl-D-Aspartate; D051153:Wnt Proteins