Cellular and molecular aspects of Goodpasture syndrome.
Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane. The clinical condition of the Goodpasture syndrome is characterized by an acute necrotizing glomerulonephritis, often with accompanying pulmonary hemorrhage. Notably, the Goodpasture antigen has been localized to the noncollagenous domain of the alpha3 chain of type IV collagen. Additionally, human leukocyte antigen-DR2, and to a lesser extent human leukocyte antigen-DR4, have been identified as important restriction elements.  The role of T cells in Goodpasture syndrome is indicated by the highly restricted specificity of the antibody response and the strong major histocompatibility complex class II association. In this review article, we briefly describe the latest views on the molecular and cellular themes of Goodpasture syndrome.
College of Applied Medical Sciences, Prince Salman University, Al-Kharj, Saudi Arabia. falenzi@ksu.edu.sa
Faris Q
FQ
Alenzi
Mohamed L
ML
Salem
Fawwaz A
FA
Alenazi
Richard K
RK
Wyse
D019867:Anti-Glomerular Basement Membrane Disease / Q000235:genetics / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer
D001323:Autoantibodies; D000939:Epitopes; D006680:HLA Antigens; D007074:Immunoglobulin G; C119090:CERT1 protein, human; D017346:Protein Serine-Threonine Kinases