Stochastic gene expression stabilization as a new therapeutic strategy for cancer.
Current differentiation therapies for cancer may not be effective because it might not be enough to only use molecules targeting chromatin remodelers. It may also be necessary to stabilize the re-expressed genes to convert malignant cells into benign ones.
LISBP (UMR CNRS 5504; UMR INRA 792), INSA de Toulouse, Toulouse, France. capp@insa-toulouse.fr
Jean-Pascal
JP
Capp
D002450:Cell Communication; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D005818:Genetic Engineering / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D013269:Stochastic Processes; D059016:Tumor Microenvironment