Role of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesis.
Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to oncogenesis by modulating innate immunity in patients with NPC and Burkett's lymphoma. BARF1 is a homolog of the human proto-oncogene c-fms and is expressed as a latent gene in NPC. Reconstitution of NPC-type EBV infection using NPC-derived cell lines shows that BARF1 contributes to the tumorigenicity of NPC cells.
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan. takada@igm.hokudai.ac.jp
Kenzo
K
Takada
D001483:Base Sequence; D002277:Carcinoma; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology; D018448:Models, Immunological; D008969:Molecular Sequence Data; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology / Q000821:virology; D000090063:Proto-Oncogene Mas; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology* / Q000502:physiology
C086495:BARF1 protein, Human herpesvirus 4; C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012367:RNA, Viral; D014764:Viral Proteins