Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells.
Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergic mediators, including prostaglandin D₂ (PGD₂), leukotriene C₄ (LTC₄), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extract inhibited the production of interleukin-6, PGD₂ and LTC₄, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology, Cheongwon, Korea.
Hee-Sung
HS
Chae
Piseth
P
Khiev
Hyeong-Kyu
HK
Lee
Sei-Ryang
SR
Oh
Young-Won
YW
Chin
D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology* / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D061207:Calcium Ionophores / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D002725:Chloroform / Q000737:chemistry*; D027424:Cinnamomum / Q000737:chemistry*; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000276:immunology; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D017997:Leukotriene C4 / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D015230:Prostaglandin D2 / Q000276:immunology / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D061207:Calcium Ionophores; D002273:Carcinogens; D045424:Complex Mixtures; D015850:Interleukin-6; D017997:Leukotriene C4; D000001:Calcimycin; D002725:Chloroform; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D013755:Tetradecanoylphorbol Acetate; D015230:Prostaglandin D2