Liquid antisolvent precipitation process for solubility modulation of bicalutamide.
Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E5 and Poloxamer 407 were shortlisted as a hydrophilic polymer and surfactant, respectively, for the process. Process optimization was done with respect to the hydrophilic polymer, surfactant and drug loading concentration. The resultant microcrystals were characterized with various instrumental techniques for material characterization such as IR, DSC, SEM, XRD, particle size, specific surface area and dissolution kinetics.
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019 India.
Tarique Ali
TA
Meer
Kiran P
KP
Sawant
Purnima D
PD
Amin
D000813:Anilides / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D009570:Nitriles / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013499:Surface Properties; D014105:Tosyl Compounds / Q000737:chemistry*
D000813:Anilides; D009570:Nitriles; D012997:Solvents; D014105:Tosyl Compounds; D002482:Cellulose; C053541:bicalutamide; C109691:microcrystalline cellulose