Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer.
OBJECTIVE
To evaluate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings of bone metastasis in prostate cancer patients.


METHODS
Sixteen men with a diagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 Tesla. The mean contrast agent concentration vs time curves for bone metastasis and normal bone were calculated and K(trans) and ve values were estimated and compared.


RESULTS
An early significant enhancement (wash-out: n = 6, plateau: n = 8 and persistent: n = 2) was detected in all bone metastases (n = 16). Bone metastasis from prostate cancer showed significant enhancement and high K(trans) and ve values compared to normal bone which does not enhance in the elderly population. The mean K(trans) was 0.101/min and 0.0051/min (P < 0.001), the mean ve was 0.141 and 0.0038 (P < 0.001), for bone metastases and normal bone, respectively.


CONCLUSIONS
DCE-MRI and its quantitative perfusion parameters may have a role in improving the detection of skeletal metastasis in prostate cancer patients.
Arda Kayhan, Fatma Nur Soylu, Hatice Lakadamyalı, Ila Sethi, Gregory Karczmar, Aytekin Oto, Department of Radiology, University of Chicago, Chicago, IL 60637, United States.
Arda
A
Kayhan
Cheng
C
Yang
Fatma Nur
FN
Soylu
Hatice
H
Lakadamyalı
Ila
I
Sethi
Gregory
G
Karczmar
Walter
W
Stadler
Aytekin
A
Oto