Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians.
Inhibition of epidermal growth factor receptor (EGFR) has become an important target in the treatment of advanced non-small cell lung cancer (NSCLC). Erlotinib and gefitinib, two small molecular agents that target the tyrosine kinase domain of the EGFR, were approved in many countries for the treatment of locally advanced or metastatic NSCLC as a second- or third-line regimen. Since then, randomized trials have evaluated the role of these two targeted agents alone or combined with chemotherapy in maintenance and first-line settings. This review summarizes the results of recent clinical trials with these tyrosine kinase inhibitors, with a focus on erlotinib, as first-line treatment towards a form of personalized medicine aimed at improving clinical outcome in advanced NSCLC.
Shanghai Pulmonary Hospital, Cancer Institute, School of Medicine, Tongji University, Shanghai, PR China.
Yongsheng
Y
Wang
Gerald
G
Schmid-Bindert
Caicun
C
Zhou