Trimetazidine blocks store-operated Ca(2+) channels in HL-60 and THP-1 cell lines and inhibits the secretion of tumor necrosis factor.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia.
M G
MG
Vinokurov
E I
EI
Astashkin
M M
MM
Yurinskaya
M G
MG
Glezer
K E
KE
Sobolev
S V
SV
Grachev
D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D045744:Cell Line, Tumor; D005089:Exocytosis / Q000187:drug effects*; D006801:Humans; D014292:Trimetazidine / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015220:Calcium Channels; D014409:Tumor Necrosis Factor-alpha; D014292:Trimetazidine; D002118:Calcium