Thymic function after allogeneic stem cell transplantation is dependent on graft source and predictive of long term survival.
T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome. In this retrospective study 210 patients were analyzed with regards to levels of T-cell receptor excision circles (TRECs) during the first 24 months after transplantation. We could for the first time show a significant correlation between the use of bone marrow grafts and higher TREC levels >6 months post-ASCT (p<0.001). Treatment with anti-thymocyte globulin was correlated with lower TREC levels ≤6 months post-ASCT (p<0.001). Patients with TREC levels above median at 3 months had a superior overall survival, 80% vs. 56% (p=0.002), and lower transplantation-related mortality, 7% vs. 21% (p=0.01). We conclude that graft source and conditioning regimen may have a significant effect on T-cell reconstitution after ASCT and can thus affect outcome. These results strongly support the use of TREC measurement as part of the standard repertoire of immunological monitoring after ASCT.
Center for Allogeneic Stem Cell Transplantation, B87, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. darius.sairafi@ki.se
Darius
D
Sairafi
Jonas
J
Mattsson
Michael
M
Uhlin
Mehmet
M
Uzunel
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D033581:Stem Cell Transplantation; D015996:Survival Rate; D013950:Thymus Gland / Q000276:immunology*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
D011948:Receptors, Antigen, T-Cell