Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.
Pathogenic Helicobacter pylori strains can selectively activate epithelial mitogen-activated protein kinase (MAPK) signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties.
Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ramakrishnan
R
Sitaraman
Dawn A
DA
Israel
Judith
J
Romero-Gallo
Richard M
RM
Peek
D001422:Bacterial Adhesion; D004912:Erythrocytes / Q000382:microbiology*; D017353:Gene Deletion; D016480:Helicobacter pylori / Q000201:enzymology* / Q000472:pathogenicity*; D006461:Hemolysis; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010740:Phospholipases / Q000235:genetics / Q000378:metabolism*
D020928:Mitogen-Activated Protein Kinases; D010740:Phospholipases