Early-onset childhood sarcoidosis with incidental multiple enchondromatosis.
The triad of rash, arthritis, and uveitis seems to be characteristic for early-onset childhood sarcoidosis. We describe an interesting case of early-onset childhood sarcoidosis coexisting enchondromatosis, which clinically masquerade as Langerhans cell histiocytosis. A 33 months old girl presented with skin rash, subcutaneous nodules with polyarthritis, and revealed the involvement of lymph nodes as well as spleen during work-up. She also presented with multiple osteolytic lesions which pathologically proven enchondromatosis. Oral prednisone was prescribed at 2 mg/kg/day for 2 months until when subcutaneous nodules and joint swellings almost disappeared, and then slowly tapered over a period of 5 months. We report an unusual case of early-onset childhood sarcoidosis presented with osteolytic bone lesions which were irrelevant to sarcoidosis.
Department of Pediatrics, Wonkwang University Sanbon Medical Center, Gunpo, Korea.
Jong-Hwa
JH
Lee
Yeon-Jung
YJ
Lim
Seunghun
S
Lee
Kyung Bin
KB
Joo
Yun Young
YY
Choi
Chan-Kum
CK
Park
Young-Ho
YH
Lee
D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004687:Enchondromatosis / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005076:Exanthema / Q000209:etiology; D005260:Female; D006801:Humans; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011241:Prednisone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
D000893:Anti-Inflammatory Agents; D011241:Prednisone