Polymorphism identification in the goat KITLG gene and association analysis with litter size.
This study reported the analysis of KIT ligand (KITLG) gene polymorphisms in 681 goats of three breeds: Xinong Saanen (SN), Guanzhong (GZ), and Boer (BG). In addition, the study identified three allelic variants: g.769T>C and g.817G>T in SN and GZ breeds, and g.9760G>C in the three goat breeds. The g.769T>C and g.817G>T loci were closely linked (r(2)  > 0.33). All the single nucleotide polymorphism loci were in Hardy-Weinberg disequilibrium (P < 0.05). Significant associations were found for litter size with all three loci. Therefore, these results suggest that the KITLG gene is a strong candidate gene affecting litter size in goats.
College of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, China.
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XP
An
J X
JX
Hou
G
G
Li
Y X
YX
Song
J G
JG
Wang
Q J
QJ
Chen
Y H
YH
Cui
Y F
YF
Wang
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Cao
D000818:Animals; D005260:Female; D006041:Goats / Q000235:genetics*; D008098:Litter Size; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019089:Stem Cell Factor / Q000235:genetics*
D019089:Stem Cell Factor