Palladium-catalyzed silyl C(sp3)-H bond activation.
The first transition-metal-catalyzed activation of silyl C(sp(3))-H bond was realized and synthetically applied. A variety of organic skeletons substituted with SiMe(3) groups could undergo the Pd-catalyzed intramolecular coupling reaction, resulting in an unprecedented synthetic method for yielding six-membered silacycles. It was found that the adjacent Si atom played an essential role for the activation of the C(sp(3))-H bond of the SiMe(3) group; no activation reaction of the C(sp(3))-H bond of the CMe(3) group took place under the same reaction conditions.
Beijing National Laboratory for Molecular Sciences, College of Chemistry, Peking University, Beijing, 100871, China.
Yun
Y
Liang
Weizhi
W
Geng
Junnian
J
Wei
Kunbing
K
Ouyang
Zhenfeng
Z
Xi
D002384:Catalysis; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D010165:Palladium