Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetes.
Tuberculosis (TB) remains a major global disease, and diabetes, which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique  model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB  susceptibility.
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA. huiqi.qu@uth.tmc.edu
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D000328:Adult; D000368:Aged; D018106:CD28 Antigens / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006593:Hexokinase / Q000235:genetics*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*
D018106:CD28 Antigens; D006593:Hexokinase