Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives.
A mild and efficient Cu(2)O-catalyzed domino intramolecular C-N coupling/C-Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in good to excellent yields even under air atmosphere.
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321004, People's Republic of China.
Ziming
Z
Xia
Kuo
K
Wang
Jiening
J
Zheng
Zheyong
Z
Ma
Zhanguo
Z
Jiang
Xiaoxia
X
Wang
Xin
X
Lv
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007093:Imidazoles / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry*
D007093:Imidazoles; D007211:Indoles; D011083:Polycyclic Compounds; D003300:Copper; C029899:imidazole