Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama's catalyst β-ICD.
We report the first example of catalytic asymmetric direct amination of α-monosubstituted nitroacetates using di-tert-butyl azodicarboxylate. The simple and easily available Hatakeyama's catalyst β-ICD 11 was found to be a highly enantioselective catalyst for this reaction.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
Cong-Bin
CB
Ji
Yun-Lin
YL
Liu
Xiao-Li
XL
Zhao
Yin-Long
YL
Guo
Hao-Yang
HY
Wang
Jian
J
Zhou
D000085:Acetates / Q000737:chemistry*; D000586:Amination; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D006912:Hydroxyquinolines / Q000737:chemistry*; D015394:Molecular Structure; D011812:Quinuclidines / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D001391:Azo Compounds; D006912:Hydroxyquinolines; D011812:Quinuclidines; C517075:beta-isocupreidine; C572223:di-tert-butyl azodicarboxylate; C028257:nitroacetic acid