Use of expiratory change in bladder pressure to assess expiratory muscle activity in patients with large respiratory excursions in central venous pressure.
BACKGROUND
Expiratory muscle activity may cause the end-expiratory central venous pressure (CVP) to greatly overestimate right atrial transmural pressure.


METHODS
We recorded CVP and expiratory change in intra-abdominal pressure (ΔIAP) in 39 patients who had a respiratory excursion in CVP from end-expiration to end-inspiration (CVP(ee)-CVP(ei)) ≥ 8 mmHg. Uncorrected CVP was measured at end-expiration, and corrected CVP was calculated as uncorrected CVP-ΔIAP. In 13 patients measurements were repeated during relaxed breathing.


RESULTS
The CVP(ee)-CVP(ei) was 15.2 ± 6.3 mmHg (range 8-34 mmHg), and ΔIAP was 7.4 ± 6.0 mmHg (range 0-30 mmHg). Uncorrected CVP was 18.3 ± 6.1 mmHg, and corrected CVP was 10.9 ± 3.9 mmHg. There was a significant positive correlation between CVP(ee)-CVP(ei) and ΔIAP (r = 0.814). However, some patients with a large CVP(ee)-CVP(ei) had negligible ΔIAP. In a subset of 13 patients with active expiration who had a relaxed CVP tracing available for comparison, the difference between uncorrected CVP and relaxed CVP was much greater than the difference between corrected CVP and relaxed CVP (7.3 ± 3.0 vs. 1.1 ± 0.7 mmHg, p < 0.001).


CONCLUSIONS
Patients with large respiratory excursions in CVP often have significant expiratory muscle activity that will cause their CVP to overestimate transmural right atrial pressure. The magnitude of expiratory muscle activity can be assessed by measuring ΔIAP. Subtracting ΔIAP from the end-expiratory CVP usually provides a reasonable estimate of the CVP that would be obtained if exhalation were passive.
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Minneapolis, USA. leath001@umn.edu
James W
JW
Leatherman
Christina
C
Bastin-Dejong
Robert S
RS
Shapiro
Ramiro
R
Saavedra-Romero
D000009:Abdominal Muscles / Q000502:physiology*; D002496:Central Venous Pressure / Q000502:physiology*; D045853:Exhalation / Q000502:physiology*; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007362:Intensive Care Units; D008991:Monitoring, Physiologic / Q000379:methods; D001743:Urinary Bladder / Q000502:physiology*; D014546:Urinary Catheterization