Dupuytren's disease.
Dupuytren's disease is a benign contractile disorder of the hand. The condition commonly affects older men of Celtic descent. Although fibroproliferation and collagen alteration play a role in its etiology, defining a cause remains elusive. Nonoperative intervention for advanced disease has shown only short-term benefit. Therefore, open fasciectomy has become the mainstay of treatment. Associated morbidity and recurrence have prompted investigation into less invasive techniques, including needle aponeurotomy and enzymatic fasciotomy. Data from phase III studies using injectable collagenase are changing treatment algorithms. Postoperative rehabilitation includes nighttime splinting and immediate active range of motion exercises to facilitate return to function.
Department of Orthopedic Surgery, Mercy St Vincent Medical Center, Toledo, Ohio, USA.
Michael
M
Worrell
D017364:Collagenases / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004387:Dupuytren Contracture / Q000175:diagnosis* / Q000628:therapy*; D000071938:Fasciotomy; D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods*
D017364:Collagenases