title: Closing the loop for Deep Brain Stimulation implants enables personalized healthcare for Parkinson's disease patients.
abstract: DEEP brain stimulation implants have improved life quality for more than 70,000 patients world-wide with diseases like Parkinson's, essential tremor, or obsessive-compulsive disorder where pharmaceutical therapies alone could not offer sufficient relief. Still, optimization and monitoring relies heavily on regular clinical visits, putting a burden on patient's comfort and clinicians. Permanent monitoring and combination with other patient health signals could ultimately lead to a personalized closed-loop therapy with remote quality monitoring. This requires technological improvements on the DBS implants such as integration of recording capabilities for brain activity monitoring, active low-power electronics, rechargeable battery technology, and body sensor networks for integration with e.g. gait, speech, and other vital information sensors on the patient's body and a link to a telemedicine platform using mobile technologies.
authors.affiliation: Imec, Leuven, Belgium. wolfgang.eberle@imec.be
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eberle
authors.forename: Julien
authors.initials: J
authors.lastname: Penders
authors.forename: Refet Firat
authors.initials: RF
authors.lastname: Yazicioglu
mesh_terms: D001676:Biofeedback, Psychology / Q000295:instrumentation*; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis* / Q000628:therapy*; D057285:Precision Medicine / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration; D013813:Therapy, Computer-Assisted / Q000295:instrumentation*