title: Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection.
abstract: We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.
authors.affiliation: INSERM UMR-S 945, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guergnon
authors.forename: C
authors.initials: C
authors.lastname: Dalmasso
authors.forename: P
authors.initials: P
authors.lastname: Broet
authors.forename: L
authors.initials: L
authors.lastname: Meyer
authors.forename: S J
authors.initials: SJ
authors.lastname: Westrop
authors.forename: N
authors.initials: N
authors.lastname: Imami
authors.forename: E
authors.initials: E
authors.lastname: Vicenzi
authors.forename: G
authors.initials: G
authors.lastname: Morsica
authors.forename: M
authors.initials: M
authors.lastname: Tinelli
authors.forename: B
authors.initials: B
authors.lastname: Zanone Poma
authors.forename: C
authors.initials: C
authors.lastname: Goujard
authors.forename: V
authors.initials: V
authors.lastname: Potard
authors.forename: F M
authors.initials: FM
authors.lastname: Gotch
authors.forename: C
authors.initials: C
authors.lastname: Casoli
authors.forename: A
authors.initials: A
authors.lastname: Cossarizza
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: P
authors.initials: P
authors.lastname: Debré
authors.forename: J F
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: M
authors.initials: M
authors.lastname: Galli
authors.forename: B
authors.initials: B
authors.lastname: Autran
authors.forename: D
authors.initials: D
authors.lastname: Costagliola
authors.forename: G
authors.initials: G
authors.lastname: Poli
authors.forename: I
authors.initials: I
authors.lastname: Theodorou
authors.forename: A
authors.initials: A
authors.lastname: Riva
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics; D018450:Disease Progression; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D055106:Genome-Wide Association Study; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C080521:HCP5 long noncoding RNA, human; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014157:Transcription Factors; C464855:ZSCAN31 protein, human