title: [Flavonoid correction of functional elasticity of erythrocyte membranes and hemorheological disorders during oxidative stress caused by chronic physical overstrain in mice].
abstract: Effect of a course of treatment by bioflavonoids quercetin and diquertin on the physical work capacity, oxidant and antioxidant status of organism, and hemorheological parameters and deformability of erythrocytes have been studied under conditions of chronic physical overstrain in mice caused by sequential extraordinary running load. The drugs effectively prevent the development of oxidative stress, loss of elasticity of erythrocyte membranes and growth in dynamic blood viscosity in microcirculatory link of hemodynamics. It is established that both bioflavonoids significantly increase the physical work capacity of animals and prevent from the development of physical overstrain syndrome.
authors.forename: I S
authors.initials: IS
authors.lastname: Tipikin
authors.forename: E A
authors.initials: EA
authors.lastname: Rozhkova
authors.forename: R D
authors.initials: RD
authors.lastname: Seĭfulla
authors.forename: Z G
authors.initials: ZG
authors.lastname: Ordzhonikidze
authors.forename: V V
authors.initials: VV
authors.lastname: Paniushkin
authors.forename: A A
authors.initials: AA
authors.lastname: Kravtsov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000008:administration & dosage; D001809:Blood Viscosity / Q000187:drug effects*; D002374:Catalase / Q000032:analysis / Q000378:metabolism; D004548:Elasticity; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D011794:Quercetin / Q000008:administration & dosage* / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; C473100:diquertin; D008315:Malondialdehyde; D011794:Quercetin; D002374:Catalase