title: Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines.
abstract: An iron(III)-catalyzed three-component coupling reaction of alkynes, CH(2)Cl(2) and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl(3) and 1,1,3,3-tetramethylguanidine.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Song
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: He
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Yang
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Dou
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005290:Ferric Compounds / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000480:Alkynes; D000588:Amines; D005290:Ferric Compounds; D011437:Propylamines; C009054:propargylamine; D008752:Methylene Chloride; D010293:Pargyline