title: Clinical use of meconium fatty acid ethyl esters for identifying children at risk for alcohol-related disabilities: the first reported case.
abstract: Fatty acid ethyl esters (FAEEs) in meconium are validated biomarkers of heavy fetal alcohol exposure that may potentially be used clinically for identifying children at risk for alcohol-related disabilities. However, until now, FAEEs have been largely used anonymously in epidemiological studies, and by child protection authorities in need for verification of heavy alcohol use in pregnancy. Here we describe the first case of a neonate identified as part of a research study on a pilot neonatal screening program for prenatal alcohol exposure. The neonate's meconium tested high for FAEEs (52 nmol/g; positive cut-off ≥ 2 nmol/g), which prompted active follow-up of the infant's development, identifying early neurocognitive problems and allowing initiation of a remedial program.
authors.affiliation: Division of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, Toronto, Ontario; and Department of Pharmacology & Toxicology, University of Toronto, Ontario, Canada.
authors.forename: Irene
authors.initials: I
authors.lastname: Zelner
authors.forename: Sarit
authors.initials: S
authors.lastname: Shor
authors.forename: Hazel
authors.initials: H
authors.lastname: Lynn
authors.forename: Henry
authors.initials: H
authors.lastname: Roukema
authors.forename: Lisa
authors.initials: L
authors.lastname: Lum
authors.forename: Kirsten
authors.initials: K
authors.lastname: Eisinga
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis* / Q000378:metabolism; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008470:Meconium / Q000737:chemistry* / Q000378:metabolism; D015997:Neonatal Screening / Q000379:methods; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D005227:Fatty Acids