title: Effects of intravenous, low-dose ketamine-diazepam sedation on the results of hematologic, plasma biochemical, and coagulation analyses in cats.
abstract: OBJECTIVE
  To evaluate the effects of an IV, low-dose ketamine-diazepam combination used for short-duration chemical restraint on the results of clinicopathologic testing in cats and to assess its practicality and tolerance.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  42 client-owned cats of various breeds, ages, and health status.
  
  
  METHODS
  Blood samples were obtained just prior to and just after IV injection of ketamine chlorhydrate (10 mg) and diazepam (0.5 mg). A CBC, plasma biochemistry panel, and coagulation profile were performed on each sample (ie, before and after chemical restraint). Practicality of the procedure was assessed, and cats were monitored for immediate and delayed effects.
  
  
  RESULTS
  Significant changes were observed for most of the analytes tested. However, the magnitude of the observed changes was notably low and likely not of clinical relevance. The chemical-restraint procedure appeared effective, safe, and well tolerated.
  
  
  CONCLUSIONS
  The IV, low-dose ketamine-diazepam combination used for short-duration chemical restraint in the present study may be suitable to assist physical restraint for blood sampling for assessment of hematologic, serum biochemical, and coagulation parameters in cats.
authors.affiliation: Département des Sciences Cliniques, Ecole Nationale Vétérinaire, 23, Chemin des Capelles, BP 87614, 31076, Toulouse Cedex 3, France. b.reynolds@envt.fr
authors.forename: Brice S
authors.initials: BS
authors.lastname: Reynolds
authors.forename: Anne
authors.initials: A
authors.lastname: Geffré
authors.forename: Nathalie H
authors.initials: NH
authors.lastname: Bourgès-Abella
authors.forename: Sophie
authors.initials: S
authors.lastname: Vaucoret
authors.forename: Maité
authors.initials: M
authors.lastname: Mourot
authors.forename: Jean-Pierre D
authors.initials: JP
authors.lastname: Braun
authors.forename: Catherine
authors.initials: C
authors.lastname: Trumel
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary*; D001777:Blood Coagulation / Q000187:drug effects*; D002415:Cats; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011446:Prospective Studies
chemical_list: D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D007649:Ketamine; D003975:Diazepam