title: Synthesis, structure and antifungal activity of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones.
abstract: A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl(3) under reflux conditions. The structures of the title compounds were confirmed by ¹H-NMR, ¹³C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani.
authors.affiliation: College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Weng
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Cheng-Xia
authors.initials: CX
authors.lastname: Tan
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects; D020231:Colletotrichum / Q000187:drug effects; D003460:Crystallization; D018360:Crystallography, X-Ray; D003500:Cyclization; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012232:Rhizoctonia / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D052160:Benzothiazoles; D010069:Oxadiazoles