title: A comparative study of chronic kidney disease in dogs and cats: induction of cyclooxygenases.
abstract: The present study investigated whether renal cyclooxygenase (COX) induction is associated with the severity of chronic kidney disease (CKD) in dogs and cats. The collected kidneys were examined histopathologically and immunohistochemically. The immunoreactivities of COX-1 and COX-2 were evaluated quantitatively, and the correlations to the plasma creatinine concentrations, glomerular size, glomerulosclerosis, interstitial fibrosis, and interstitial cell infiltration were evaluated statistically. Immunoreactivities for COX-1 were heterogeneously observed in the medullary distal tubules and collecting ducts; no correlations with the severity of renal damage were detected. Immunoreactivities for COX-2 were heterogeneously observed in the macula densa (MD) regions. In dogs, the percentage of COX-2-positive MD was significantly correlated with the glomerular size. In cats, glomeruli with COX-2-positive MD had significantly higher sclerosis scores than those with COX-2-negative MD. In conclusion, renal COX-2 is induced in canine and feline CKD, especially in relation to the glomerular changes.
authors.affiliation: Laboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan. yabu@agri.kagoshima-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.forename: Sawane
authors.initials: S
authors.lastname: Mitani
authors.forename: Mariko
authors.initials: M
authors.lastname: Sawa
authors.forename: Keijiro
authors.initials: K
authors.lastname: Mizukami
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujiki
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000201:enzymology*; D002415:Cats; D051545:Cyclooxygenase 1 / Q000235:genetics / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D004790:Enzyme Induction / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000201:enzymology / Q000662:veterinary*
chemical_list: D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2