title: IVUS-based assessment of 3D morphology and virtual histology: prediction of atherosclerotic plaque status and changes.
abstract: Comprehensive analysis of coronary morphology, plaque composition, hemodynamics, and systemic cardiovascular biomarkers is hypothesized to allow prediction of plaque development. We report the status of a comprehensive project, in which baseline and follow-up intravascular ultrasound imaging of coronary arteries during routine coronary interventions serve as a source of quantitative data for development of a predictive classifier for determining plaque progression over the course of a year from baseline data.
authors.affiliation: Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA. milan-sonka@uiowa.edu
authors.forename: Milan
authors.initials: M
authors.lastname: Sonka
authors.forename: Richard W
authors.initials: RW
authors.lastname: Downe
authors.forename: Justin W
authors.initials: JW
authors.lastname: Garvin
authors.forename: John
authors.initials: J
authors.lastname: Lopez
authors.forename: Tomas
authors.initials: T
authors.lastname: Kovarnik
authors.forename: Andreas
authors.initials: A
authors.lastname: Wahle
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D003124:Colorimetry / Q000379:methods; D003331:Coronary Vessels / Q000473:pathology; D018450:Disease Progression; D001330:Electronic Data Processing; D006321:Heart / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012815:Signal Processing, Computer-Assisted; D014463:Ultrasonography / Q000379:methods; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D015415:Biomarkers