title: Meta-analysis for cyclin E in lung cancer survival.
abstract: BACKGROUND
  To assess the prognosis value of cyclin E expression in survival of patients with lung cancer (LC), we performed a systematic review of the literature with meta-analysis.
  
  
  METHODS
  Electronic databases were used to identify published studies before August 2011. Pooled hazard ratio (HR) with 95% confidence interval (95% CI) was used to estimate the strength of the association of cyclin E expression with survival of LC patients. Heterogeneity and publication bias were also assessed.
  
  
  RESULTS
  Fourteen studies (2606 cases) were eligible and subjected to analysis. Cyclin E over-expression was found to be a strong predictor of poor prognosis in LC patients (HR: 1.38, 95% CI: 1.07-1.79; P=0.014). When only non-small cell lung cancer (NSCLC) was considered, the combined HR was 1.53 (95% CI: 1.19-1.97, P=0.001). A significant association was also evident when the analysis was limited to studies involving adenocarcinoma (AD), but not squamous cell carcinoma (SQ). Publication bias was absent. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average.
authors.affiliation: Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China. bbmchln@126.com
authors.forename: Li-nian
authors.initials: LN
authors.lastname: Huang
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Feng-dan
authors.initials: FD
authors.lastname: Hu
authors.forename: Bei-lei
authors.initials: BL
authors.lastname: Gong
authors.forename: Cheng-Ling
authors.initials: CL
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
mesh_terms: D019927:Cyclin E / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D019927:Cyclin E