title: Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma.
abstract: OBJECTIVE
  Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question.
  
  
  METHODS
  We prepared Dermatophagoides farinae-sensitized mice as an asthma model, and then infected them with RSV and analyzed the changes in airway responsiveness and the cell populations and cytokine levels of bronchoalveolar lavage fluid.
  
  
  RESULTS
  RANTES synthesis increased in response to RSV infection in both control mice and in asthma model (D. farinae) mice. However, there was no significant difference in the amount of RANTES produced following RSV infection between control and D. farinae mice. RSV infection affected neither interferon-γsynthesis nor airway responsiveness in either control or D. farinae mice.
  
  
  CONCLUSIONS
  RSV infection did not induce more RANTES in a murine model of asthma than in control mice.
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Changchun, China.
authors.forename: Yanghua
authors.initials: Y
authors.lastname: Ju
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Choi
authors.forename: Huisu
authors.initials: H
authors.lastname: Lee
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Sulmui
authors.initials: S
authors.lastname: Won
authors.forename: Yoon Hong
authors.initials: YH
authors.lastname: Chun
authors.forename: Jong-Seo
authors.initials: JS
authors.lastname: Yoon
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Kim
authors.forename: Joon Sung
authors.initials: JS
authors.lastname: Lee