title: Epidemiological, clinical features and susceptibility pattern of shigellosis in the buea health district, Cameroon.
abstract: BACKGROUND
  Shigellosis is an acute invasive enteric infection caused by bacteria belonging to the genus Shigella; it is clinically manifested by bloody diarrhoea. Shigellosis is endemic in many developing countries including Cameroon and also occurs in epidemics causing considerable morbidity and mortality. This study evaluated the epidemiological and clinical features of Shigella and the resistance pattern of isolates to commonly used antibiotics in the Buea Health District in Cameroon, from April to August, 2010.
  
  
  RESULTS
  Of the 223 stool samples cultured, 10 (4.5%) yielded Shigella species. Isolation rate was observed to be more in children below 15 years (7.89%), and also higher in rural areas (6.35%). All 10 isolates showed resistance to at least two antibiotics and 9 (90%) were multi-drug resistant. The highest resistance rates were encountered with cotrimoxazole (90%) and amoxicillin (80%). Least resistance was observed with azithromycin (10%).
  
  
  CONCLUSIONS
  Shigellosis is more prevalent in children below 15 years in the Buea District. There is a high level of resistance to most of the antibiotics used for the treatment of shigellosis including extended-spectrum beta-lactamases (ESBLs) as well as evidence of resistance to quinolones. Azithromycin was found to be the drug of choice for shigellosis in this setting.
authors.affiliation: Medicine Programme, Department of Biomedical Sciences, Faculty of Health Sciences Laboratory, University of Buea, P,O,Box 63, Buea, Cameroon. juleclement@yahoo.fr.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Njunda
authors.forename: Jules Cn
authors.initials: JC
authors.lastname: Assob
authors.forename: Dickson S
authors.initials: DS
authors.lastname: Nsagha
authors.forename: Henri Lf
authors.initials: HL
authors.lastname: Kamga
authors.forename: Maghah P
authors.initials: MP
authors.lastname: Awafong
authors.forename: Elroy P
authors.initials: EP
authors.lastname: Weledji