title: Factors associated with survival after resection of colorectal adenocarcinoma in 314 patients.
abstract: BACKGROUND
  An analysis of perioperative factors that were independently associated with survival up to 1000 days after scheduled colorectal adenocarcinoma resections in 314 patients.
  
  
  METHODS
  The association of 16 perioperative variables with postoperative survival and critical care unit (CCU) admission after scheduled resections for colorectal adenocarcinoma between September 2005 and March 2009 was analysed using multivariable Cox regression analyses and Fisher's exact tests.
  
  
  RESULTS
  We followed survivors for a mean of 983 days (range 696-1000 days). Average annual postoperative mortality was 8.5%, 14% after surgery performed in 2005, and 3% after surgery in 2009. Risk of mortality was independently associated with five variables after stratifying for date of surgery: attending a preoperative high-risk clinic [hazard ratio (HR) 0.42, P=0.006], worse World Health Organization performance status (HR 2.1, P=0.001), BMI (HR 0.92, P=0.009), higher nodal stage (HR 2.6, P<0.0001), and unplanned critical care admission (HR 7.2, P<0.0001). Patients who attended the preoperative clinic (207) were older, with worse renal function and ASA grade, than those who did not (107). Planned postoperative critical care admission was more common in patients who attended the high-risk clinic (24% vs 12%, P=0.01) and may have partly accounted for the observed mortality difference.
  
  
  CONCLUSIONS
  Immediate perioperative care may have prolonged effects on postoperative survival. Specialized preoperative assessment clinics may reduce mortality after colorectal surgery.
authors.affiliation: Department of Anaesthetics, Torbay Hospital, South Devon Healthcare NHS Foundation Trust, Lawes Bridge, Torquay, Devon TQ2 7AA, UK. john.carlisle@nhs.net
authors.forename: J
authors.initials: J
authors.lastname: Carlisle
authors.forename: M
authors.initials: M
authors.lastname: Swart
authors.forename: E J C
authors.initials: EJ
authors.lastname: Dawe
authors.forename: M
authors.initials: M
authors.lastname: Chadwick
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000556:secondary / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000379:methods; D015179:Colorectal Neoplasms / Q000191:economics / Q000401:mortality* / Q000601:surgery*; D004812:Epidemiologic Methods; D005260:Female; D017721:Hospital Costs / Q000706:statistics & numerical data; D006801:Humans; D007362:Intensive Care Units / Q000191:economics; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D019990:Perioperative Care / Q000191:economics / Q000379:methods; D057234:Preoperative Period; D011379:Prognosis; D016896:Treatment Outcome