title: In vivo polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in rodent cerebral cortex.
abstract: Maintaining a reliable neural interface is a well-known challenge with implanted neural prostheses. Here we evaluate a method of forming an integrated neural interface through polymerization of PEDOT in vivo. Polymerization resulted in lower impedance and improved recording quality of local field potentials on implanted electrodes in the rat cerebral cortex. Histological analysis by optical microscopy confirmed successful integration of the PEDOT within tissue surrounding implanted electrodes. This technique offers a unique neural interfacing approach with potential to improve the long-term functionality of neural prostheses.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. swilks@purdue.edu
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Wilks
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Woolley
authors.forename: Liangqi
authors.initials: L
authors.lastname: Ouyang
authors.forename: David C
authors.initials: DC
authors.lastname: Martin
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Otto
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D002540:Cerebral Cortex / Q000502:physiology*; D004553:Electric Conductivity; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008297:Male; D008422:Materials Testing; D011108:Polymers / Q000138:chemical synthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001672:Biocompatible Materials; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene)