title: [Expression of EphA7 and MTDH and clinicopathological  significance in the squamous cell cancer of the tongue].
abstract: OBJECTIVE
  To determine the expression levels of EphA7 and MTDH and detect their clinicopathological significance in the peritumoral normal tissues and the squamous cell cancer of the tongue.
  
  
  METHODS
  Envision immunohistochemistry was used to assay the expression levels of EphA7 and MTDH in the conventional paraffin-embedded sections from specimens of squamous cell cancer (n=45) and peritumoral normal tissues (n=10).
  
  
  RESULTS
  The positIVe rates of EphA7 and MTDH were significantly higher in the squamous cell cancer than those in the peritumoral normal tissues ( χ(2)(EphA7)=4.14; χ(2)(MTDH)= 5.25; P < 0.05). The positIVe rates of EphA7 and MTDH expression were significantly lower in the cases of histological grade I-II,clinical stage I-II, and no-metastasis of neck lymph node than those in the histological grade III-IV, clinical stage III-IV, and metastasis of neck lymph node (P <0.05 or P <0.01).
  
  
  CONCLUSIONS
  The expression levels of EphA7 and/or MTDH might have important effect on the carcinogenesis and progression of tongue cancer. Overexpression of EphA7 and/or MTDH might have poor prognosis.
authors.affiliation: Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Nianfeng
authors.initials: N
authors.lastname: Deng
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011379:Prognosis; D016601:RNA-Binding Proteins; D036141:Receptor, EphA7 / Q000378:metabolism*; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins; D036141:Receptor, EphA7