title: [Biosynthetic pathway and synthetic strategy of spinosad--a review].
abstract: Spinosad is a novel macrolide insecticide produced by Saccharopolyspora spinasa, widely used in agriculture. Here its biosynthetic pathway, and key regulatory nodes were reviewed and analyzed. A synthetic strategy to reprogram spinosad biosynthetic pathway was proposed.
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou 730000, China. liyue200906@163.com
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Chang
authors.forename: Keqian
authors.initials: K
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D053898:Biosynthetic Pathways; D004338:Drug Combinations; D007306:Insecticides / Q000378:metabolism*; D018942:Macrolides / Q000378:metabolism*; D016930:Saccharopolyspora / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D007306:Insecticides; D018942:Macrolides; C415329:spinosad