title: A molecular peptide beacon for the ratiometric sensing of nucleic acids.
abstract: A pyrene-functionalized cationic oligopeptide 1 efficiently binds to double-stranded DNA, as shown by different spectrophotochemical studies. Upon binding, the conformation of 1 changes from a folded to an extended form, which leads to a distinct change in the fluorescence properties. Thus, 1 functions as a molecular peptide beacon, and as it is easily taken up by cells, 1 can also be used for imaging of nucleic acids within cells.
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany.
authors.forename: Junchen
authors.initials: J
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zou
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Sicking
authors.forename: Ivo
authors.initials: I
authors.lastname: Piantanida
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry* / Q000494:pharmacology; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D011721:Pyrenes / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D015345:Oligonucleotide Probes; D009842:Oligopeptides; D011721:Pyrenes; D004247:DNA; C030984:pyrene