title: Acute generalized exanthematous pustulosis to amoxicillin associated with parvovirus B19 reactivation.
abstract: We report the case of a 22-year-old male patient with 2 episodes, 4 months apart, of acute generalized exanthematous pustulosis (AGEP) associated with oral intake of amoxicillin and simultaneous reactivation of parvovirus B19 infection proven by positive polymerase chain reaction test in the skin fragment and blood sample and elevation of the IgG antibodies titer. To our knowledge, this is the first report of AGEP resulting from the interaction between drug hypersensitivity and the reactivation of parvovirus B19. A combination of an immunological reaction to the drug and virus infection could be responsible for the clinical picture.
authors.affiliation: Hospital São João EPE, Dermatology and Venereology, Alameda Prof. Hernani Monteiro, Porto, Portugal. anagruia@yahoo.com
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Calistru
authors.forename: Carmen
authors.initials: C
authors.lastname: Lisboa
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Cunha
authors.forename: Herberto
authors.initials: H
authors.lastname: Bettencourt
authors.forename: Filomena
authors.initials: F
authors.lastname: Azevedo
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced*; D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016732:Parvovirus B19, Human / Q000502:physiology*; D016133:Polymerase Chain Reaction; D014775:Virus Activation
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin