title: Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population.
abstract: OBJECTIVE
  The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the C1qA gene region with systemic lupus erythematosus (SLE) in a Chinese Han population.
  
  
  METHODS
  Chinese SLE patients (n = 748) and ethnically- and geographically-matched healthy controls (n = 750) were genotyped for the C1qA region SNPs, rs172378 and rs665691, by using the Sequenom MassArray system.
  
  
  RESULTS
  The Chinese Han SLE patients and controls had statistically similar frequencies of alleles, genotypes, and haplotypes of C1qA polymorphisms. Moreover, no association signal was detected on different genetic models (additive, dominant, and recessive) or in SLE subgroups stratified by various clinical manifestations.
  
  
  CONCLUSIONS
  The C1qA SNPs, rs172378 and rs665691, confer no genetic predisposition to SLE in a Chinese Han population.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: C-W
authors.initials: CW
authors.lastname: Cao
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: H-X
authors.initials: HX
authors.lastname: Luan
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: C-H
authors.initials: CH
authors.lastname: Li
authors.forename: C-J
authors.initials: CJ
authors.lastname: Hu
authors.forename: S-L
authors.initials: SL
authors.lastname: Zhang
authors.forename: X-F
authors.initials: XF
authors.lastname: Zeng
authors.forename: F-C
authors.initials: FC
authors.lastname: Zhang
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Li
authors.forename: C-Q
authors.initials: CQ
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D015922:Complement C1q / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D015922:Complement C1q