title: Lp-PLA2: inflammatory biomarker of vascular risk in multiple sclerosis.
abstract: A member of the A2 phospholipase superfamily, the enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2), is involved in atherogenic processes. Lp-PLA2 mass and activity were measured by the enzyme-linked immunosorbent assay and by a colorimetric method, respectively, and compared among 63 multiple sclerosis (MS) patients and 47 age-matched healthy controls (HCs). Lp-PLA2 plasma levels were significantly higher in MS patients (236.7 ± 10 ng/ml) compared to HCs (197.0 ± 7 ng/ml) (p = 0.003), but LP-PLA2 activity did not differ between the two groups. Both Lp-PLA2 plasma mass and activity were higher in secondary progressive (mass 247.0 ±15.5 ng/ml, p = 0.05; activity 156.1 ±6 nmol/min/ml, p = 0.003) compared to relapsing-remitting MS patients (mass 227.0 ± 16 ng/ml; activity 128.8 ± 5 nmol/min/ml) and compared to HCs. Lp-PLA2 plasma activity was associated with measures of MS clinical disability. However, this association was attenuated after adjustment for the components of lipid profiles.
authors.affiliation: Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14203, USA. zs2@buffalo.edu
authors.forename: Zohara
authors.initials: Z
authors.lastname: Sternberg
authors.forename: Alison
authors.initials: A
authors.lastname: Drake
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Sternberg
authors.forename: Ralph H B
authors.initials: RH
authors.lastname: Benedict
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.forename: David
authors.initials: D
authors.lastname: Hojnacki
authors.forename: Bianca
authors.initials: B
authors.lastname: Weinstock-Guttmann
authors.forename: Frederick E
authors.initials: FE
authors.lastname: Munschauer
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood* / Q000276:immunology; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008055:Lipids; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase