title: Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis.
abstract: Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kitajima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Komizu
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry* / Q000494:pharmacology; D005434:Flow Cytometry; D006801:Humans; D020128:Inhibitory Concentration 50; D008081:Liposomes / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009361:Neoplasm Invasiveness; D012516:Osteosarcoma / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D008081:Liposomes; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine