title: Chronic behavior evaluation of a micro-machined neural implant with optimized design based on an experimentally derived model.
abstract: Understanding the mechanical interactions between implants and the surrounding tissue is known to have an important role for improving the bio-compatibility of such devices. Using a recently developed model, a particular micro-machined neural implant design aiming the reduction of insertion forces dependence on the insertion speed was optimized. Implantations with 10 and 100 μm/s insertion speeds showed excellent agreement with the predicted behavior. Lesion size, gliosis (GFAP), inflammation (ED1) and neuronal cells density (NeuN) was evaluated after 6 week of chronic implantation showing no insertion speed dependence.
authors.affiliation: Bioelectronic Systems Group, Imec, 3001 Heverlee, Belgium. andreial@imec.be
authors.forename: Alexandru
authors.initials: A
authors.lastname: Andrei
authors.forename: Marleen
authors.initials: M
authors.lastname: Welkenhuysen
authors.forename: Lieveke
authors.initials: L
authors.lastname: Ameye
authors.forename: Bart
authors.initials: B
authors.lastname: Nuttin
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eberle
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology*; D019544:Equipment Failure Analysis; D008137:Longitudinal Studies; D008297:Male; D008904:Miniaturization; D019736:Prostheses and Implants / Q000009:adverse effects*; D011474:Prosthesis Design; D051381:Rats; D017208:Rats, Wistar