title: Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening.
abstract: Unprecedented regioselective acylation of flavonoid aglycones was achieved using Candida antarctica lipase B (CALB). The rapid screening of product formation was performed by the use of the high resolution phenol-type OH (1)H NMR spectral region recorded after the addition of picric acid.
authors.affiliation: Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina GR-45110, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Kyriakou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Primikyri
authors.forename: Pantelis
authors.initials: P
authors.lastname: Charisiadis
authors.forename: Maria
authors.initials: M
authors.lastname: Katsoura
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Gerothanassis
authors.forename: Haralambos
authors.initials: H
authors.lastname: Stamatis
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Tzakos
mesh_terms: D000215:Acylation; D055162:Biocatalysis; D002175:Candida / Q000201:enzymology*; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism; D005656:Fungal Proteins; D006027:Glycosides / Q000737:chemistry* / Q000378:metabolism; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D054730:Protein Interaction Domains and Motifs; D013997:Time Factors
chemical_list: D005419:Flavonoids; D005656:Fungal Proteins; D006027:Glycosides; D008049:Lipase; C431349:lipase B, Candida antarctica