title: [Lymphomatoid papulosis: clinical and pathological findings in 18 patients].
abstract: BACKGROUND
  Lymphomatoid papulosis (LyP) is a CD30(+) lymphoproliferative skin disease that has been described in association with Hodgkin lymphoma. It has also been reported to progress to mycosis fungoides or cutaneous anaplastic large-cell lymphoma.
  
  
  OBJECTIVE
  To study the clinical and histologic features of LyP and response to treatment in a patient series.
  
  
  METHODS
  For this retrospective, descriptive, observational study of patients with histologically confirmed LyP and sufficient follow-up data on record, we extracted histologic findings on skin biopsy, clinical presentation, clinical course, and response to treatments.
  
  
  RESULTS
  Eighteen patients (10 male, 8 female) were identified. Most biopsies (14/18, 78%) showed a wedge-shaped lymphocytic infiltrate with CD30(+), CD3(+), and CD56(-) cells. A type A histologic pattern was present in the biopsies of 83% of the patients. The most common presentation (83%) consisted of papules on the trunk; for 62% LyP resolved after a single episode. Twelve percent of the patients developed mycosis fungoides (mean follow-up, 7 years); no other associations were noted.
  
  
  CONCLUSIONS
  Although few series of patients with LyP have been published in recent years, the findings reported generally coincide with our observations.
  
  
  CONCLUSIONS
  LyP is typically a CD30(+) lymphoproliferative disorder that usually runs a benign course and responds well to treatment.
authors.affiliation: Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain. montsefdez@msn.com
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Guarino
authors.forename: R
authors.initials: R
authors.lastname: Carrillo-Gijón
authors.forename: P
authors.initials: P
authors.lastname: Jaén-Olasolo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017731:Lymphomatoid Papulosis / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult