title: Anticancer activity and anti-inflammatory studies of 5-aryl-1,4-benzodiazepine derivatives.
abstract: A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.
authors.affiliation: Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Circuito Exterior, Coyoacan, C.P. 04510, Mexico D.F., Mexico. margar@servidor.unam.mx
authors.forename: Cortez-Maya
authors.initials: CM
authors.lastname: Sandra
authors.forename: Cortes Cortes
authors.initials: CC
authors.lastname: Eduardo
authors.forename: Hernandez-Ortega
authors.initials: HO
authors.lastname: Simon
authors.forename: Ramirez Apan
authors.initials: RA
authors.lastname: Teresa
authors.forename: Nieto Camacho
authors.initials: NC
authors.lastname: Antonio
authors.forename: Irina V
authors.initials: IV
authors.lastname: Lijanova
authors.forename: Martinez-Garcia
authors.initials: MG
authors.lastname: Marcos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D005260:Female; D054879:Halogenation; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D009195:Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001569:Benzodiazepines; D009195:Peroxidase