title: The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.
abstract: Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson's disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primates have set the grounds for its successful translation to PD patients. Since then, this model has allowed gaining significant insights in the underlying mechanisms of action of DBS and is currently being used for the development of new stimulation techniques. Altogether, this underpins the high potential of this preclinical model for future translation of DBS research in PD.
authors.affiliation: Institute of Neuroscience and Medicine-Neuromodulation, Research Centre Juelich, Germany. p.tass@fz-juelich.de
authors.forename: Peter A
authors.initials: PA
authors.lastname: Tass
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.forename: Christian
authors.initials: C
authors.lastname: Hauptmann
authors.forename: Sandra
authors.initials: S
authors.lastname: Dovero
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
authors.forename: Thomas
authors.initials: T
authors.lastname: Boraud
authors.forename: Wassilios G
authors.initials: WG
authors.lastname: Meissner
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods* / Q000639:trends*; D004195:Disease Models, Animal; D006801:Humans; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control*; D011323:Primates; D057170:Translational Research, Biomedical / Q000639:trends*
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine