title: Iridoids from the roots of Valeriana jatamansi.
abstract: Two new iridoids, jatamanvaltrates N (1) and O (2), together with four known compounds (3-6), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D, and 2D NMR) and by comparison of their NMR spectral data with those of related compounds. All the isolated compounds were evaluated for their neuroprotective effects, and only compound 1 showed weak neuroprotective activities.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Fang
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Li
authors.forename: Yuan-Qiang
authors.initials: YQ
authors.lastname: Guo
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D014632:Valerian / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; D018696:Neuroprotective Agents; C570649:jatamanvaltrate N; C570648:jatamanvaltrate O