title: CCK, PYY and PP: the control of energy balance.
abstract: The control of food intake consists of neural and hormonal signals between the gut and central nervous system (CNS). Gut hormones such as CCK, PYY and PP signal to important areas in the CNS involved in appetite regulation to terminate a meal. These hormones can act directly via the circulation and activate their respective receptors in the hypothalamus and brainstem. In addition, gut vagal afferents also exist, providing an alternative pathway through which gut hormones can communicate with higher centres through the brainstem. Animal and human studies have demonstrated that peripheral administration of certain gut hormones reduces food intake and leads to weight loss. Gut hormones are therefore potential targets in the development of novel treatments for obesity and analogue therapies are currently under investigation.
authors.affiliation: Department of Investigative Medicine, Imperial College London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Simpson
authors.forename: J
authors.initials: J
authors.lastname: Parker
authors.forename: J
authors.initials: J
authors.lastname: Plumer
authors.forename: S
authors.initials: S
authors.lastname: Bloom
mesh_terms: D000818:Animals; D001069:Appetite Regulation; D001921:Brain / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism*; D004734:Energy Metabolism; D041981:Gastrointestinal Tract / Q000294:innervation / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism*; D018013:Receptors, Neuropeptide / Q000378:metabolism; D012528:Satiety Response; D015398:Signal Transduction
chemical_list: D018013:Receptors, Neuropeptide; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin