title: Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development.
abstract: With a world market of more than four million tons per year, l-amino acids are among the most important products in industrial biotechnology. The recent years have seen a tremendous progress in the development of tailor-made strains for such products, intensively driven from systems metabolic engineering, which upgrades strain engineering into a concept of optimization on a global scale. This concept seems especially valuable for efficient amino acid production, demanding for a global modification of pathway fluxes - a challenge with regard to the high complexity of the underlying metabolism, superimposed by various layers of metabolic and transcriptional control.
authors.affiliation: Institute of Biochemical Engineering, Technische Universität Braunschweig, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Becker
authors.forename: Christoph
authors.initials: C
authors.lastname: Wittmann
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis*; D001419:Bacteria / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D060847:Metabolic Engineering / Q000379:methods*; D058615:Synthetic Biology / Q000379:methods*; D049490:Systems Biology / Q000379:methods*
chemical_list: D000596:Amino Acids