title: Time course of histone deacetylase 1 and acetylated H3 and H4 histones in the brain of rats treated with ladasten.
abstract: We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
authors.affiliation: Laboratory of Molecular Immunology and Pharmacology, Institute of Biochemistry and Genetics, Research Center of Russian Academy of Sciences, Ufa, Russia. miph@anrb.ru
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Salimgareeva
authors.forename: S V
authors.initials: SV
authors.lastname: Sadovnikov
authors.forename: R S
authors.initials: RS
authors.lastname: Yamidanov
authors.forename: Yu V
authors.initials: YV
authors.lastname: Vakhitova
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000107:Acetylation; D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D056284:Histone Deacetylase 1 / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011499:Protein Processing, Post-Translational; D051381:Rats
chemical_list: D002843:Chromatin; D006657:Histones; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D056284:Histone Deacetylase 1; D000218:Adamantane