title: Ciprofloxacin hydrochloride-loaded glyceryl monostearate nanoparticle: factorial design of Lutrol F68 and Phospholipon 90G.
abstract: OBJECTIVE
  This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl.
  
  
  METHODS
  Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solvent diffusion evaporation method and investigated for particle size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE) and drug release behaviour.
  
  
  RESULTS
  Variations in SLN composition resulted in particle sizes between 170 and 810 nm and ZPs between 8 and 14 mV. The maximum EE was found to be 26.3% with particle size of 188.8 nm. SLN can sustain the release of drug for up to 15 h and it shows Higuchi matrix model as the best-fitted model. SLNs were stable without aggregation of particles under storage conditions.
  
  
  CONCLUSIONS
  The results of this study provide the framework for further study involving the SLN formulation for hydrophilic drug molecule.
authors.affiliation: Institute of Research and Development, Gujarat Forensic Sciences University, Sector 18A, Gandhinagar-382007, Gujarat, India. malay2512@yahoo.co.in
authors.forename: Malay
authors.initials: M
authors.lastname: Shah
authors.forename: Yadvendra
authors.initials: Y
authors.lastname: Agrawal
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D005989:Glycerides; D057927:Hydrophobic and Hydrophilic Interactions; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D005989:Glycerides; C506200:Lutrol; D053769:Nanocapsules; C048159:glyceryl monostearate; D011092:Polyethylene Glycols; D002939:Ciprofloxacin