title: [Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To examine the expression and clinical significance of the Stat3 and Cyclin D1 in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  The expression of Stat3 and Cyclin D1 in LSCC tissue were detected by the RT-PCR and Western blot method respectively, and then the relationship between Stat3 and Cyclin D1 protein expression level and relevant clinical factors of LSCC was explored.
  
  
  RESULTS
  Compared to the normal larynx mucosa group, the expression level of Stat3 and Cyclin D1 was significantly higher in LSCC (P < 0.01). The high expression level of Stat3 and Cyclin D1 protein in LSCC was correlated with the clinical stage, tumor differentiation and lymph node metastases (P < 0.01). The expression level of Stat3 was positively correlated with that of Cyclin D1, The correlation coefficient(r) was 0.564 (P < 0.01) for the protein expression and 0.552 (P < 0.01) for the mRNA expression.
  
  
  CONCLUSIONS
  Stat3 signaling pathway may play an important role in the tumorigenesis and progression of LSCC. The expression level of Stat3 and its target gene Cyclin D1 can reflect the malignancy degree of LSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Medical College of Xi' an Jiaotong University, Xi' an710061, China.
authors.forename: Lingu
authors.initials: L
authors.lastname: Wang
authors.forename: Xinhu
authors.initials: X
authors.lastname: Duan
authors.forename: Xiabin
authors.initials: X
authors.lastname: Tang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shao
authors.forename: Ruimin
authors.initials: R
authors.lastname: Zhao
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Qian
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: C530104:CCND1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D019938:Cyclin D1