title: [Case of an elderly patient with community acquired bacterial meningitis due to extended spectrum β lactamase producing Escherichia coli].
abstract: Community acquired bacterial meningitis due to extended spectrum β lactamase-producing Escherichia coli is very rare. We report the case of a 72-year-old woman being treated for longstanding diabetes mellitus. She developed lower back pain accompanied by elevated body temperature, and was transported to the emergency unit in our hospital five days later because of impaired consciousness. An abdominal plane CT showed acute pyelonephritis and a brain MRI showed inflammatory exudate in the posterior horn of her bilateral ventricles. A lumbar puncture was performed, and examination of the cerebrospinal fluid revealed a marked elevation in her cell count (polymorphonuclear leukocytes dominant) that we diagnosed as bacterial meningitis. Initially, she was treated with intravenous meropenem, ceftriaxon, and vancomycin. Extended spectrum β lactamase-producing Escherichia coli were then detected in her urinary and blood cultures, and the antibiotics were changed to intravenous meropenem, gentamicin, and intrathecal gentamicin. Her clinical symptoms improved, but her inflammatory reaction was prolonged and we detected spondylitis. She was then treated with levofloxacin, and the inflammatory reaction improved. Extended spectrum β lactamase-producing Escherichia coli should be taken into consideration as a cause of community acquired bacterial meningitis.
authors.affiliation: Department of Cerebrovascular Disease, Yodogawa Christian Hospital.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Gon
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Otsubo
authors.forename: Syo
authors.initials: S
authors.lastname: Murase
authors.forename: Kwiyounn
authors.initials: K
authors.lastname: Park
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hara
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology*; D004926:Escherichia coli / Q000201:enzymology / Q000302:isolation & purification* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D000077731:Meropenem; D013845:Thienamycins / Q000008:administration & dosage; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D013845:Thienamycins; D001618:beta-Lactamases; D000077731:Meropenem