title: Clinically relevant extracellular-matrix scaffolds for cell transplantation and vascular repair.
abstract: Due to the very limited ability of cardiac tissue to self-regenerate, the replacement of damaged cardiomyocytes and the repair of damaged extracellular matrix (ECM) are highly sought-after therapeutic strategies. Cell transplantation in ECM scaffolds has been shown to improve retention, phenotype, and function in vascular and muscle repair. In addition to cellular patches that involve the use of biomaterial scaffolds in combination with cells, acellular patches may have a role in intrinsically recruiting cells to damaged areas. This review focuses on the clinically relevant ECM scaffolds, their interactions with cells to stimulate functions such as adhesion, migration, proliferation, and differentiation, and their intrinsic role in ECM remodeling leading to vascular and possibly myocardial repair.
authors.affiliation: Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Tiwari-Pandey
authors.forename: Hadi
authors.initials: H
authors.lastname: Toeg
authors.forename: Frank W
authors.initials: FW
authors.lastname: Sellke
authors.forename: Marc
authors.initials: M
authors.lastname: Ruel
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D017690:Cell Transplantation / Q000379:methods*; D005109:Extracellular Matrix / Q000378:metabolism*; D006331:Heart Diseases / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D012038:Regeneration; D054457:Tissue Scaffolds