title: Modeling signaling pathways in articular cartilage.
abstract: Chondrocytes, the only cell type in articular cartilage, are responsible for maintaining the composition of cartilage extracellular matrix (ECM) through a complex interplay of anabolic and catabolic stimuli. Although understanding the way chondrocytes respond to stimuli is of utmost importance for shedding light into the etiology of joint diseases, an integrative approach to studying their signaling transduction mechanisms is yet to be introduced. Herein, we propose an approach that combines high throughput proteomic measurements and state of the art optimization algorithms to construct a predictive model of chondrocyte signaling network, downstream of 78 receptors of interest.
authors.affiliation: National Technical University of Athens, Mechanical Engineering Department, Heroon Polytechneiou 9, Zografou 15773, Athens, Greece.
authors.forename: Ioannis N
authors.initials: IN
authors.lastname: Melas
authors.forename: Aikaterini D
authors.initials: AD
authors.lastname: Chairakaki
authors.forename: Alexander
authors.initials: A
authors.lastname: Mitsos
authors.forename: Zoe
authors.initials: Z
authors.lastname: Dailiana
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Provatidis
authors.forename: Leonidas G
authors.initials: LG
authors.lastname: Alexopoulos
mesh_terms: D002358:Cartilage, Articular / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010750:Phosphoproteins / Q000378:metabolism; D040901:Proteomics; D015398:Signal Transduction
chemical_list: D010750:Phosphoproteins