title: Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease.
abstract: OBJECTIVE
  To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI).
  
  
  METHODS
  Data were obtained by the German Dementia Competence Network. A total of 185 memory clinic patients fulfilling broad criteria for MCI (1 SD deficit in memory tests or in nonmemory tests) were assessed with an extended neuropsychological battery, which included the Free and Cued Selective Reminding Test (FCSRT), the word list learning task from the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NP), and the Logical Memory (LM) paragraph recall test from the Wechsler Memory Scale-Revised. CSF was obtained from all patients.
  
  
  RESULTS
  A total of 74 out of 185 subjects with MCI (40%) had a CSF profile consistent with AD (Aβ(1-42)/tau ratio; CSF AD+ group). FCSRT measures reflecting both free and cued recall discriminated best between CSF AD+ and CSF AD- patients, and significantly improved CSF AD classification accuracy, as compared with CERAD delayed recall and LM delayed recall.
  
  
  CONCLUSIONS
  Cued recall deficits are most closely associated with CSF biomarkers indicative of AD in subjects with MCI. This novel finding complements results from prospective clinical studies and provides further empirical support for cued recall as a specific indicator of prodromal AD, in line with recently proposed research criteria.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. Michael.Wagner@uni-bonn.de
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.forename: F M
authors.initials: FM
authors.lastname: Reischies
authors.forename: M
authors.initials: M
authors.lastname: Daerr
authors.forename: S
authors.initials: S
authors.lastname: Wolfsgruber
authors.forename: F
authors.initials: F
authors.lastname: Jessen
authors.forename: J
authors.initials: J
authors.lastname: Popp
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Hüll
authors.forename: L
authors.initials: L
authors.lastname: Frölich
authors.forename: H
authors.initials: H
authors.lastname: Hampel
authors.forename: R
authors.initials: R
authors.lastname: Perneczky
authors.forename: O
authors.initials: O
authors.lastname: Peters
authors.forename: H
authors.initials: H
authors.lastname: Jahn
authors.forename: C
authors.initials: C
authors.lastname: Luckhaus
authors.forename: H-J
authors.initials: HJ
authors.lastname: Gertz
authors.forename: J
authors.initials: J
authors.lastname: Schröder
authors.forename: J
authors.initials: J
authors.lastname: Pantel
authors.forename: P
authors.initials: P
authors.lastname: Lewczuk
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid* / Q000523:psychology; D003463:Cues; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins