title: Imaging the sialome during zebrafish development with copper-free click chemistry.
abstract: The sialome comprises sialylated glycoproteins and glycolipids that play essential roles in cell-cell communication. Using azide-modified molecular precursors of sialic acids and copper-free click chemistry, we visualized the spatiotemporal dynamics of the sialome in live zebrafish embryos.
authors.affiliation: Department of Chemistry, University of California, B84 Hildebrand Hall 1460, Berkeley, CA 94720, USA.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Dehnert
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Baskin
authors.forename: Scott T
authors.initials: ST
authors.lastname: Laughlin
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Beahm
authors.forename: Natasha N
authors.initials: NN
authors.lastname: Naidu
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Amacher
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: Bertozzi
mesh_terms: D000818:Animals; D057930:Click Chemistry; D003300:Copper; D006017:Glycolipids / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D012794:Sialic Acids / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D013194:Staining and Labeling; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D006017:Glycolipids; D012794:Sialic Acids; D029961:Zebrafish Proteins; D003300:Copper