title: Anthracyclinones from Micromonospora sp.
abstract: Four new anthracyclinones, 4,6,11-trihydroxy-9-propyltetracene-5,12-dione (1), 1-methoxy-9-propyltetracene-6,11-dione (2), 7,8,9,10-tetrahydro-9-hydroxy-1-methoxy-9-propyltetracene-6,11-dione (3), and 10β-carbomethoxy-7,8,9,10-tetrahydro-4,6,7α,9α,11-pentahydroxy-9-propyltetracene-5,12-dione (4), were isolated from a strain of Micromonospora sp. associated with the tunicate Eudistoma vannamei. All structures were established by 1D and 2D NMR (COSY, HSQC, HMBC, NOESY) and HRESIMS experiments. Compounds 1 and 4 were cytotoxic against the HCT-8 human colon adenocarcinoma cell line, with IC(50) values of 12.7 and 6.2 μM, respectively, while compounds 2 and 3 were inactive.
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, 60.021-970, Brazil.
authors.forename: Thiciana da S
authors.initials: Tda S
authors.lastname: Sousa
authors.forename: Paula C
authors.initials: PC
authors.lastname: Jimenez
authors.forename: Elthon G
authors.initials: EG
authors.lastname: Ferreira
authors.forename: Edilberto R
authors.initials: ER
authors.lastname: Silveira
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.forename: Otília D L
authors.initials: OD
authors.lastname: Pessoa
authors.forename: Letícia V
authors.initials: LV
authors.lastname: Costa-Lotufo
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008847:Micromonospora / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata
chemical_list: D018943:Anthracyclines; D000880:Anthraquinones; D000970:Antineoplastic Agents