title: Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population.
abstract: OBJECTIVE
  Behçet's disease is one of the major aetiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified six microsatellite markers as disease susceptibility loci for Japanese patients with Behçet's disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study.
  
  
  METHODS
  Study participants included 119 Behçet's disease patients and 141 controls. All were enrolled in Korea. Association between the six reported microsatellite markers (D3S0186i, D6S0014i, D6S0032i, 536G12A, D12S0645i and D22S0104i) and Behçet's disease was analysed. HLA-B was genotyped by sequence-based typing methods.
  
  
  RESULTS
  A microsatellite marker located near the HLA-B region demonstrated significant association with Behçet's disease (P = 0.028). The genotype and phenotype frequencies of the HLA-B*51 gene were significantly increased in patients (23.1 and 39.5%, respectively) compared with healthy controls (11.2 and 20.1%, respectively; P < 0.001).
  
  
  CONCLUSIONS
  Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behçet's disease in a Korean population.
authors.affiliation: Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Horie
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Kanda
authors.forename: Kousuke
authors.initials: K
authors.lastname: Noda
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
authors.forename: Kyung Sook
authors.initials: KS
authors.lastname: Park
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
mesh_terms: D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D001528:Behcet Syndrome / Q000208:ethnology* / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D015235:HLA-B Antigens