title: Spontaneous alternation and spatial learning in Dab1scm (scrambler) mutant mice.
abstract: Homozygous Dab1scm mutants with cell ectopias in cerebellar cortex, hippocampus, and neocortex were compared with non-ataxic heterozygous and wild-type controls in spontaneous alternation and Morris water maze tests. Although there were no group differences in alternation rates, wild-type and heterozygote groups alternated above chance levels, whereas homozygous Dab1scm mutants did not. In the Morris water maze, Dab1scm mutants were impaired in both hidden and visible platform subtests. The deficits in spontaneous alternation and water maze measures reproduce the phenotype previously described in Reln(rl-Orl) mutants, attributed to disturbance of the same molecular pathway involving reelin.
authors.affiliation: Université Henri Poincaré, Nancy I, Laboratoire de Nutrition Génétique et Exposition aux Risques Environnementaux, INSERM U954, Service de Microscopie Electronique, Faculté de Médecine, 54500 Vandoeuvre-les-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Jacquelin
authors.forename: C
authors.initials: C
authors.lastname: Strazielle
authors.forename: R
authors.initials: R
authors.lastname: Lalonde
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010641:Phenotype; D000091042:Reelin Protein; D013037:Spatial Behavior / Q000502:physiology*
chemical_list: C103773:Dab1 protein, mouse; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717128:Reln protein, mouse