title: Oral transmission of L-type bovine spongiform encephalopathy in primate model.
abstract: We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U710, Montpellier, France. nadine.frances-mestre@univmontp2.fr
authors.forename: Nadine
authors.initials: N
authors.lastname: Mestre-Francés
authors.forename: Simon
authors.initials: S
authors.lastname: Nicot
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rouland
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Biacabe
authors.forename: Isabelle
authors.initials: I
authors.lastname: Quadrio
authors.forename: Armand
authors.initials: A
authors.lastname: Perret-Liaudet
authors.forename: Thierry
authors.initials: T
authors.lastname: Baron
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Verdier
mesh_terms: D000821:Animal Feed; D000818:Animals; D001921:Brain / Q000473:pathology; D002417:Cattle; D016565:Cheirogaleidae; D016643:Encephalopathy, Bovine Spongiform / Q000145:classification / Q000635:transmission*; D005260:Female; D008297:Male; D011328:Prions / Q000378:metabolism
chemical_list: D011328:Prions