title: Design of a new probe for tumor treatment in the alternate thermal system based on numerical simulation.
abstract: A new probe for tumor treatment is designed and simulated in this study. This probe combines the cryosurgery and hyperthermia which is suitable for the treatment of subcutaneous tumors. Simulations of the cooling and heating processes demonstrate that the probes are capable of treating the tumor effectively. And the numerical results indicate that the lengths of the probe, the diameters of the inner tube and the pressures of liquid nitrogen influence the probes' cooling ability. The temperature responses at the tumor base induced by different probes are similar, though the great differences appear on the treatment interface of the probes, thus the temperature gradient within the tumor. Based on the simulation results, the heating effect of the probe is shown to be effective in damaging the tumor while protecting normal tissue in the surrounding. Animal experiments will be carried out using this type of probe to treat tumor in the near future.
authors.affiliation: School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, PR China.
authors.forename: Zhanghao
authors.initials: Z
authors.lastname: Cai
authors.forename: Mingyang
authors.initials: M
authors.lastname: Song
authors.forename: Jianqi
authors.initials: J
authors.lastname: Sun
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Lisa X
authors.initials: LX
authors.lastname: Xu
mesh_terms: D000465:Algorithms; D000818:Animals; D045744:Cell Line, Tumor; D003198:Computer Simulation; D003452:Cryosurgery / Q000379:methods; D004867:Equipment Design; D005615:Freezing; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D015233:Models, Statistical; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D011846:Radio Waves; D013696:Temperature; D013997:Time Factors