title: A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia.
abstract: Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1;19), +8, 12q-, +21, +22 and high hyperdiploidy with 51-65 chromosomes, and lower incidences of t(9;22) and -5/5q- than adult ones (all p<0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.
authors.affiliation: Center for Stem Cell, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xin_li6666@mail.hust.edu.cn
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.forename: Wen
authors.initials: W
authors.lastname: Du
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Li
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Chen
authors.forename: Hongrui
authors.initials: H
authors.lastname: Li
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Lannan
authors.initials: L
authors.lastname: Zhang
authors.forename: Shiang
authors.initials: S
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003582:Cytogenetics / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D009367:Neoplasm Staging / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D055815:Young Adult