title: Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia.
abstract: The abnormal synchronisation of neural networks may underlie some of the deficits observed in schizophrenia. Abnormal synchronisation can be induced in animal models. We investigated whether acute clozapine treatment might function therapeutically by ameliorating the deficit in theta frequency coherence between the prefrontal cortex and the hippocampus that is induced in rats exposed to maternal immune activation (MIA)--a risk-factor for schizophrenia. Clozapine treatment increased synchrony levels to that of control animals in a dose-dependent manner. Clozapine's effect on synchrony may in part be mediated through increases in local synchrony that occurred in prefrontal cortex but not hippocampus.
authors.affiliation: Department of Psychology, University of Otago, Dunedin, New Zealand.
authors.forename: Desiree D
authors.initials: DD
authors.lastname: Dickerson
authors.forename: Aleisha M
authors.initials: AM
authors.lastname: Restieaux
authors.forename: David K
authors.initials: DK
authors.lastname: Bilkey
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003024:Clozapine / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D058407:Electroencephalography Phase Synchronization / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D011070:Poly I-C / Q000009:adverse effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012146:Rest; D012559:Schizophrenia / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine; D011070:Poly I-C