title: Characterization of a carcinogenesis-associated long non-coding RNA.
abstract: A negative selection strategy was used in the present study to isolate long polyA-minus RNAs from the total transcriptome and a long non-coding RNA named Yiya was identified. Yiya is a 1.9 kb long intergenic ncRNA gene mapped to chromosome 1q41, a well-established cancer susceptibility locus. Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers. Quantitative analysis further demonstrated a dynamic regulation of Yiya expression in cell cycle progression, suggesting that it was involved in cell cycle regulation. Supporting this, overexpression of Yiya promotes cell cycle progression at the G1/S transition, therefore identifying Yiya as a cell-cycle-associated long non-coding RNA.
authors.affiliation: Institute of Molecular Medicine, Peking University, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Fan
authors.initials: F
authors.lastname: Yi
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zheng
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ling
authors.forename: Jianv
authors.initials: J
authors.lastname: Ding
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: Guo
authors.forename: Weimin
authors.initials: W
authors.lastname: Mao
authors.forename: Xiongbiao
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wang
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Ding
authors.forename: Zicai
authors.initials: Z
authors.lastname: Liang
authors.forename: Quan
authors.initials: Q
authors.lastname: Du
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D016022:Case-Control Studies; D002453:Cell Cycle; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005822:Genetic Vectors; D015894:Genome, Human; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D022661:RNA, Untranslated