title: The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage.
abstract: Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell-based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells, a complete understanding of the changes in gene expression and how they are regulated is required. miRNAs have been demonstrated to play a critical role in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific miRNAs that determine stem cell fate have been identified for a number of different cell lineages; however, in the case of differentiation and specification of vascular endothelial cells, this is yet to be fully elucidated.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: Katie
authors.initials: K
authors.lastname: White
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Kane
authors.forename: Graeme
authors.initials: G
authors.lastname: Milligan
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Baker
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology*
chemical_list: D035683:MicroRNAs