title: Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.
abstract: We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.
authors.affiliation: Division of Pediatric Rheumatology, Department of Pediatrics, Inova Fairfax Hospital for Children, Fairfax, VA 22031, USA. bita.arabshahi@inova.org
authors.forename: Bita
authors.initials: B
authors.lastname: Arabshahi
authors.forename: Robert A
authors.initials: RA
authors.lastname: Silverman
authors.forename: Olcay Y
authors.initials: OY
authors.lastname: Jones
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Rider
mesh_terms: D000069594:Abatacept; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D002114:Calcinosis / Q000150:complications*; D002614:Chelating Agents / Q000008:administration & dosage*; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D012883:Skin Ulcer / Q000150:complications*; D013885:Thiosulfates / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002614:Chelating Agents; D018796:Immunoconjugates; D007166:Immunosuppressive Agents; D013885:Thiosulfates; D000069594:Abatacept; C017717:sodium thiosulfate