title: Hemopoiesis-stimulating activity of immobilized oligonucleotides and hyaluronidase during cytostatic-induced myelosuppression.
abstract: The hemopoiesis-stimulating effect of combined treatment with immobilized oligonucleotides and hyaluronidase preparations was studied during cytostatic-induced myelosuppression caused by cyclophosphamide administration. Immobilized hyaluronidase was shown to increase the efficiency of correction of changes in the erythroid and granulocytic hemopoietic stems with immobilized oligonucleotides. This potentiation of the effect of immobilized oligonucleotides by immobilized hyaluronidase was related to an increase in functional activity of committed hemopoietic precursors.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: E G
authors.initials: EG
authors.lastname: Skurikhin
authors.forename: O V
authors.initials: OV
authors.lastname: Pershina
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: A M
authors.initials: AM
authors.lastname: Khmelevskaya
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.forename: A M
authors.initials: AM
authors.lastname: Poponina
authors.forename: G N
authors.initials: GN
authors.lastname: Zjuzkov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T Ju
authors.initials: TJ
authors.lastname: Khrichkova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: A S
authors.initials: AS
authors.lastname: Tchaikovsky
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: O S
authors.initials: OS
authors.lastname: Brjushinina
authors.forename: V A
authors.initials: VA
authors.lastname: Slepichev
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D003520:Cyclophosphamide / Q000009:adverse effects / Q000494:pharmacology; D054697:Cytostatic Agents / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000494:pharmacology; D041905:Erythroid Cells / Q000187:drug effects / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009841:Oligonucleotides / Q000494:pharmacology*
chemical_list: D054697:Cytostatic Agents; D004800:Enzymes, Immobilized; D009841:Oligonucleotides; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide; D006821:Hyaluronoglucosaminidase