title: Site-specific incorporation of diamondoids on DNA using click chemistry.
abstract: A simple and robust solid phase synthetic method for the ligation of diamondoids on the phosphate backbone of DNA with "click" chemistry using [Cu(CH(3)CN)(4)]PF(6) without a stabilizing ligand is reported. It was found that as the size of dimondoid increased, a corresponding increase in melting temperature was observed.
authors.affiliation: Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors.forename: Jason B
authors.initials: JB
authors.lastname: Crumpton
authors.forename: Webster L
authors.initials: WL
authors.lastname: Santos
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D044366:Transition Temperature
chemical_list: D000480:Alkynes; D009841:Oligonucleotides; D003300:Copper; D004247:DNA