title: Spontaneous inter-conversion of insulin fibril chirality.
abstract: Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.
authors.affiliation: Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, NY 12222, USA.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kurouski
authors.forename: Rina K
authors.initials: RK
authors.lastname: Dukor
authors.forename: Xuefang
authors.initials: X
authors.lastname: Lu
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Nafie
authors.forename: Igor K
authors.initials: IK
authors.lastname: Lednev
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D018625:Microscopy, Atomic Force; D013237:Stereoisomerism
chemical_list: D000682:Amyloid; D007328:Insulin