title: Molecular characterization of Italian Candida parapsilosis isolates reveals the cryptic presence of the newly described species Candida orthopsilosis in blood cultures from newborns.
abstract: The authors report the molecular characterization of Candida parapsilosis isolates recovered from the blood and venous central catheter tips of patients admitted to different care units of the Polyclinic Hospital, University of Messina, Italy. Among 97 presumed C. parapsilosis isolates examined, 94 were identified as C. parapsilosis sensu stricto and the remaining 3 isolates were found to belong to the cryptic species Candida orthopsilosis which was recovered only from blood cultures of neonates (<30 days old) born prematurely. No C. metapsilosis was found in this study. This study emphasizes the role of C. parapsilosis as an important nosocomial pathogen, and it also describes, for the first time, the occurrence of C. orthopsilosis in newborns.
authors.affiliation: Department of Life Sciences, Marcello Malpighi Section of Microbiological, Genetic and Molecular Sciences, University of Messina, 98166 Messina, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Romeo
authors.forename: Demetrio
authors.initials: D
authors.lastname: Delfino
authors.forename: Barbara
authors.initials: B
authors.lastname: Costanzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Cascio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Criseo
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics; D002175:Candida / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis* / Q000453:epidemiology; D003428:Cross Infection; D021903:DNA, Ribosomal Spacer; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008969:Molecular Sequence Data
chemical_list: D021903:DNA, Ribosomal Spacer; D000429:Alcohol Oxidoreductases; C025192:isopropanol dehydrogenase (NADP)