title: Amyrisins A-C, O-prenylated flavonoids from Amyris madrensis.
abstract: Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC(50) values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Peng
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Hartley
authors.forename: Gary A
authors.initials: GA
authors.lastname: Fest
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008870:Microtubules / Q000187:drug effects; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D013781:Texas
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C572038:amyrisin A; C572039:amyrisin B; C572040:amyrisin C