title: Validation of a preterm infant cardiovascular system model under baroreflex control with heart rate and blood pressure data.
abstract: In this paper we present an autonomic cardiovascular model of a preterm infant of 28 weeks of gestation with a birth weight of 1000 g and a closed ductus arteriosus by the end of the first week, that is capable of describing the complex interactions between heart rate, blood pressure and respiration. The hemodynamic model consists of a pulsatile heart and several vascular compartments, and is regulated by a baroreflex control system. The model is relatively simple to allow for a mathematical analysis of the dynamics but sufficiently complex to provide a realistic representation of the underlying physiology. The model provides (beat-to-beat) values of R-R interval and blood pressure that resemble realistic signals of preterm infants. The model is validated with experimental data obtained in preterm infants.
authors.affiliation: Department of Clinical Physics of the Máxima Medical Center, Veldhoven, The Netherlands. w.jennekens@mmc.nl
authors.forename: Ward
authors.initials: W
authors.lastname: Jennekens
authors.forename: Marco
authors.initials: M
authors.lastname: Dat
authors.forename: Peter H M
authors.initials: PH
authors.lastname: Bovendeerd
authors.forename: Pieter F F
authors.initials: PF
authors.lastname: Wijn
authors.forename: Peter
authors.initials: P
authors.lastname: Andriessen
mesh_terms: D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity