title: 3-D Image-guided diffuse optical tomography using boundary element method and MPI implementation.
abstract: Boundary elements provide an attractive method for image-guided multi-modality near infrared spectroscopy in three dimensions using only surface discretization. This method operates under the assumption that the underlying tissue contains piece-wise constant domains whose boundaries are known a priori from an alternative imaging modality such as MRI or microCT. This significantly simplifies the meshing process providing both speed-up and accuracy in the forward solution. Challenges with this method are in solving dense matrices, and working with complex heterogeneous domains. Solutions to these problems are presented here, with applications in breast cancer imaging and small - animal molecular imaging.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH-03755, USA. subha@dartmouth.edu
authors.forename: Subhadra
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Hamid
authors.initials: H
authors.lastname: Ghadyani
mesh_terms: D003195:Computer Communication Networks; D004058:Diffusion; D020342:Finite Element Analysis; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008027:Light; D013997:Time Factors; D041622:Tomography, Optical / Q000379:methods*