title: Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection.
abstract: Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4α and HNF3β expression were detected by immunohistochemistry. The expression of HNF4α was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3β was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4α was different in patients with different outcome of HBV infection, high expression level of HNF4α may correlate with occurrence of SHB.
authors.affiliation: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors.forename: En-Qiang
authors.initials: EQ
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
authors.forename: Dao-Yin
authors.initials: DY
authors.lastname: Gong
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Lang
authors.initials: L
authors.lastname: Bai
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Yang
authors.forename: Xue-Zhong
authors.initials: XZ
authors.lastname: Lei
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Chen
authors.forename: Fei-Jun
authors.initials: FJ
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D015870:Gene Expression; D006509:Hepatitis B / Q000473:pathology* / Q000821:virology*; D006515:Hepatitis B virus / Q000472:pathogenicity*; D051542:Hepatocyte Nuclear Factor 3-beta / Q000096:biosynthesis*; D051557:Hepatocyte Nuclear Factor 4 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D051557:Hepatocyte Nuclear Factor 4; D051542:Hepatocyte Nuclear Factor 3-beta