title: Improvement of hemocompatibility for hydrodynamic levitation centrifugal pump by optimizing step bearings.
abstract: We have developed a hydrodynamic levitation centrifugal blood pump with a semi-open impeller for a mechanically circulatory assist. The impeller levitated with original hydrodynamic bearings without any complicated control and sensors. However, narrow bearing gap has the potential for causing hemolysis. The purpose of the study is to investigate the geometric configuration of the hydrodynamic step bearing to minimize hemolysis by expansion of the bearing gap. Firstly, we performed the numerical analysis of the step bearing based on Reynolds equation, and measured the actual hydrodynamic force of the step bearing. Secondly, the bearing gap measurement test and the hemolysis test were performed to the blood pumps, whose step length were 0 %, 33 % and 67 % of the vane length respectively. As a result, in the numerical analysis, the hydrodynamic force was the largest, when the step bearing was around 70 %. In the actual evaluation tests, the blood pump having step 67 % obtained the maximum bearing gap, and was able to improve the hemolysis, compared to those having step 0% and 33%. We confirmed that the numerical analysis of the step bearing worked effectively, and the blood pump having step 67 % was suitable configuration to minimize hemolysis, because it realized the largest bearing gap.
authors.affiliation: National Institute of Advanced Industrial Science and Technology, 1-2-1 Namiki, Tsukuba, Ibaraki 305-8564, Japan. ryo.kosaka@aist.go.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Kosaka
authors.forename: Toru
authors.initials: T
authors.lastname: Yada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Osamu
authors.initials: O
authors.lastname: Maruyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamane
mesh_terms: D001243:Assisted Circulation / Q000295:instrumentation*; D001672:Biocompatible Materials / Q000737:chemistry*; D002498:Centrifugation / Q000295:instrumentation*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006353:Heart-Assist Devices; D057446:Hydrodynamics; D008280:Magnetics / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001672:Biocompatible Materials