title: Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor.
abstract: BACKGROUND
  In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle.
  
  
  RESULTS
  We found that several major cell cycle regulatory genes were differentially expressed upon STOX1A stimulation and knockdown in the neuroblastoma cell line SH-SY5Y. This includes STOX1A dependent differential regulation of cyclin B1 expression, a cyclin which is known to regulate mitotic entry during the cell cycle. The differential regulation of cyclin B1 expression by STOX1A is direct as shown with chromatin immunoprecipitation. Results furthermore suggest that mitotic entry is enhanced through the direct upregulation of cyclin B1 expression effectuated by STOX1A.
  
  
  CONCLUSIONS
  In conclusion we hereby show that STOX1A is directly involved in the regulation of the cell cycle.
authors.affiliation: Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Daan van
authors.initials: Dv
authors.lastname: Abel
authors.forename: Omar
authors.initials: O
authors.lastname: Abdul-Hamid
authors.forename: Marie van
authors.initials: Mv
authors.lastname: Dijk
authors.forename: Cees B M
authors.initials: CB
authors.lastname: Oudejans
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D056744:Cyclin B1 / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D008969:Molecular Sequence Data; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011485:Protein Binding / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism*; D014162:Transfection; D015854:Up-Regulation / Q000235:genetics
chemical_list: C534699:CCNB1 protein, human; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D056744:Cyclin B1; C500784:STOX1 protein, human; D014157:Transcription Factors