title: Atherosclerotic risk factors and premature atherosclerosis in acromegaly before and after 48 months of octreotide-LAR treatment.
abstract: We studied premature atherosclerosis with carotid Doppler ultrasonography in active acromegaly before and after treatment. Patients (n = 27) with active acromegaly and 12 age-, gender-, and body mass index-matched healthy individuals were included in the study. Carotid intima-media thickness was decreased significantly in the inactive group after treatment (median: 0.6 mm, interquartile range [IQR]: 0.55-0.80]) when compared with the active group (median: 0.9 mm [IQR: 0.75-1.15], P < .0001), but there was no significant difference between the inactive and control groups. There was a correlation between homeostasis model of assessment-insulin resistance (P = .01, r = .41) and growth hormone (GH; P < .0001, r = .46). In conclusion, premature atherosclerosis was demonstrated in active acromegaly patients probably as a consequence of insulin resistance and direct vascular effects of GH and/or insulin-like growth factor 1.
authors.affiliation: Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
authors.forename: S N
authors.initials: SN
authors.lastname: Boysan
authors.forename: F
authors.initials: F
authors.lastname: Kantarci
authors.forename: O
authors.initials: O
authors.lastname: Celik
authors.forename: I
authors.initials: I
authors.lastname: Mihmanli
authors.forename: N
authors.initials: N
authors.lastname: Gazioglu
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
mesh_terms: D000172:Acromegaly / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D000328:Adult; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D018608:Ultrasonography, Doppler
chemical_list: D003692:Delayed-Action Preparations; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D015282:Octreotide