title: The small Rho GTPase Rif and actin cytoskeletal remodelling.
abstract: The Rif GTPase is a recent addition to small Rho GTPase family; it shares low homology with other members in the family and evolutionarily parallels with the development of vertebrates. Rif has the conserved Rho GTPase domain structures and cycles between a GDP-bound inactive form and a GTP-bound active form. In its active form, Rif signals through multiple downstream effectors. In the present review, our aim is to summarize the current information about the Rif effectors and how Rif remodels actin cytoskeleton in many aspects.
authors.affiliation: School of Biochemistry, Medical Sciences Building, University of Bristol, University Walk, Bristol BS8 1TD, UK. Lifei.Fan@bristol.ac.uk
authors.forename: Lifei
authors.initials: L
authors.lastname: Fan
authors.forename: Harry
authors.initials: H
authors.lastname: Mellor
mesh_terms: D000818:Animals; D048430:Cell Shape; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology; D009024:Morphogenesis; D009420:Nervous System / Q000166:cytology / Q000201:enzymology / Q000254:growth & development; D011554:Pseudopodia / Q000201:enzymology / Q000502:physiology; D015398:Signal Transduction; D022502:Stress Fibers / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: C419867:RHOF protein, human; D020741:rho GTP-Binding Proteins