title: Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.
abstract: Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed.
  
  
  OBJECTIVE
  To evaluate the outcome of brain MRI in girls referred with early signs of puberty in relation to age at presentation as well as clinical and biochemical parameters.
  
  
  METHODS
  A single-center study of 229 consecutive girls with early or precocious puberty who had brain imaging performed. We evaluated medical history, clinical and biochemical factors, and four groups were defined based on the outcome of their MRI.
  
  
  RESULTS
  Thirteen out of 208 (6.3%) girls with precocious puberty, but no other sign of CNS symptoms, had a pathological brain MRI. Importantly, all 13 girls were above 6 years of age, and 6 girls were even 8-9 years old. Twenty girls (9.6%) had incidental findings on brain MRI. Furthermore, 21 girls had known CNS pathology at time of evaluation. Basal LH was significantly higher in girls with newly diagnosed CNS pathology compared to girls with a non-pathological MRI (p = 0.025); no cut of value was found as values overlapped.
  
  
  CONCLUSIONS
  A high frequency of 6-8 year old girls with precocious puberty in our study had a pathological brain MRI, which could not be predicted from any clinical nor biochemical parameters. Thus, we believe that girls with precocious pubertal development of central origin before 8 years of age should continue to be examined by a brain MRI.
authors.affiliation: Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Signe Sloth
authors.initials: SS
authors.lastname: Mogensen
authors.forename: Lise
authors.initials: L
authors.lastname: Aksglaede
authors.forename: Annette
authors.initials: A
authors.lastname: Mouritsen
authors.forename: Kaspar
authors.initials: K
authors.lastname: Sørensen
authors.forename: Katharina M
authors.initials: KM
authors.lastname: Main
authors.forename: Peter
authors.initials: P
authors.lastname: Gideon
authors.forename: Anders
authors.initials: A
authors.lastname: Juul
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000473:pathology*