title: Neurogenesis: premature mitotic entry lets cleavage planes take off!
abstract: Mutations in the gene microcephalin/MCPH1 result in the neurodevelopmental disease microcephaly. A recent report provides evidence that MCPH1 controls neuroprogenitor entry into mitosis via the Chk1-Cdc25b centrosome maturation pathway.
authors.affiliation: Biozentrum, University of Basel, CH-4056 Basel, Switzerland. priyanka.singh@unibas.ch
authors.forename: Priyanka
authors.initials: P
authors.lastname: Singh
authors.forename: Clemens
authors.initials: C
authors.lastname: Cabernard
mesh_terms: D018797:Cell Cycle Proteins; D000071877:Checkpoint Kinase 1; D003598:Cytoskeletal Proteins; D006801:Humans; D008831:Microcephaly / Q000235:genetics; D008938:Mitosis; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D055495:Neurogenesis; D011494:Protein Kinases / Q000378:metabolism; D020687:cdc25 Phosphatases / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; C460645:MCPH1 protein, human; D009419:Nerve Tissue Proteins; D011494:Protein Kinases; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1; D020687:cdc25 Phosphatases