title: Mycobacterium bovis infection of total hip arthroplasty after intravesicular bacille Calmette-Guérin therapy.
abstract: Bacille Calmette-Guérin (BCG) is a live, attenuated strain of Mycobacterium bovis. Intravesicular BCG therapy is the most effective treatment for superficial bladder cancer. The most common complication of this treatment is cystitis; there is a wide range of other complications. The English-language literature includes reports of 3 total hip arthroplasty infections and 1 total knee arthroplasty infection with M bovis after BCG therapy. These secondary infections may present either acutely during the therapy, months, or even years later. In this article, we report the case of a patient who presented with a painful right hip 6 years after successful total hip arthroplasty and 3 years after treatment for bladder cancer. Left total hip arthroplasty was performed 2 years after right hip arthroplasty. Surgeons examining a painful joint arthroplasty should be particularly suspicious of infection if the patient has a history of BCG therapy.
authors.affiliation: Department of Orthopedic Surgery, McLaren Regional Medical Center, Flint, Michigan 48532, USA. ajayks1@gmail.com
authors.forename: Ajay
authors.initials: A
authors.lastname: Srivastava
authors.forename: James
authors.initials: J
authors.lastname: Ostrander
authors.forename: Sidney
authors.initials: S
authors.lastname: Martin
authors.forename: Norman
authors.initials: N
authors.lastname: Walter
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001500:BCG Vaccine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009164:Mycobacterium Infections / Q000000981:diagnostic imaging / Q000209:etiology*; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D011859:Radiography; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000188:drug therapy*
chemical_list: D001500:BCG Vaccine