title: A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation.
abstract: To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions were specific and addressed pertinent issues related to colorectal cancer with neoadjuvant chemoradiation. There is a lack of consensus on how to handle the specimen, number of sections taken, correlation with pre- and post-operative radiological imaging, and especially, regression grading schema employed. Consensus in the form of guidelines is required so that the pathological assessment of these specimens will provide clinically relevant information for patient management, irrespective of location.
authors.affiliation: Department of Cellular Pathology, John Radcliffe Hospital and University of Oxford, Oxford, UK. runjan.chetty@gmail.com
authors.forename: Runjan
authors.initials: R
authors.lastname: Chetty
authors.forename: Pelvender
authors.initials: P
authors.lastname: Gill
authors.forename: Dhirendra
authors.initials: D
authors.lastname: Govender
authors.forename: Adrian
authors.initials: A
authors.lastname: Bateman
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Chang
authors.forename: David
authors.initials: D
authors.lastname: Driman
authors.forename: Fraser
authors.initials: F
authors.lastname: Duthie
authors.forename: Marisa
authors.initials: M
authors.lastname: Gomez
authors.forename: Eleanor
authors.initials: E
authors.lastname: Jaynes
authors.forename: Cheok Soon
authors.initials: CS
authors.lastname: Lee
authors.forename: Michael
authors.initials: M
authors.lastname: Locketz
authors.forename: Claudia
authors.initials: C
authors.lastname: Mescoli
authors.forename: Corwyn
authors.initials: C
authors.lastname: Rowsell
authors.forename: Anne
authors.initials: A
authors.lastname: Rullier
authors.forename: Stefano
authors.initials: S
authors.lastname: Serra
authors.forename: Neil
authors.initials: N
authors.lastname: Shepherd
authors.forename: Eva
authors.initials: E
authors.lastname: Szentgyorgyi
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Vajpeyi
authors.forename: Lai Mun
authors.initials: LM
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D059248:Chemoradiotherapy; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy; D003625:Data Collection; D006801:Humans; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading / Q000379:methods / Q000592:standards*; D010340:Pathology, Surgical / Q000592:standards*; D013048:Specimen Handling / Q000379:methods / Q000592:standards*