title: One-step fabrication of polymeric Janus nanoparticles for drug delivery.
abstract: With its unique structure of two compartments, Janus particles can be used for many applications for which monomorphic particles are inadequate, including to be used as a drug delivery system to deliver multiple payloads with widely different solubility. Here we report on a fluidic nanoprecipitation system (FNPS), capable of fabricating biocompatible Janus polymeric nanoparticles comprised of the FDA-approved polymer poly(lactic-co-glycolic acid) (PLGA). The FNPS contains dual inlets, one for each half of the particle, that insert into the precipitation stream. The system provides a one-step approach for production of Janus polymeric particles with submicrometer diameters and is likely amenable to substantial scale-up. To the best of our knowledge, this is the first demonstration of biocompatible Janus nanoparticles that encapsulate a hydrophobic drug (paclitaxel) on one side and a hydrophilic drug (doxorubicin hydrochloride) on the other.
authors.affiliation: The Sanford-Burnham Medical Research Institute, La Jolla, California 92037, United States.
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Si
authors.initials: S
authors.lastname: Wang
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Smith
mesh_terms: D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D017239:Paclitaxel / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin; D017239:Paclitaxel