title: [Acute monoblastic leukemia following granular lymphocyte proliferative disorder].
abstract: Granular lymphocyte proliferative disorder (GLPD) is often concomitant with a malignant tumor. We report a patient who developed acute monoblastic leukemia (AMoL) following GLPD. An 82-year-old Japanese man was admitted to our hospital for anemia in December 2006. The patient was diagnosed as having GLPD. In May 2007, the lymphadenopathy developed and the blasts in peripheral blood started to increase. The monoclonal rearrangement of T-cell receptor genes was not detected on Southern blot analysis. Surface marker analysis revealed that the blasts were positive for CD13 and CD64. The level of lysozyme in serum and urine were increased. Based on these findings, he was diagnosed with AMoL. The immunohistochemistry of the bone marrow clot specimen in the diagnosis of GLPD revealed the concomitant presence of a few small clusters of CD34+ cells. This finding suggests that the granular lymphocytes responded to the early stage of AMoL. We should monitor carefully the development of acute myeloid leukemia in newly diagnosed GLPD patients.
authors.affiliation: Department of Hematology, Molecular Medicine Unit Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Itonaga
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukushima
authors.forename: Jun
authors.initials: J
authors.lastname: Taguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Imanishi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Imaizumi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000209:etiology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications*; D008297:Male