title: A single Cu(II) catalyst for the three-component coupling of diverse nitrogen sources with aldehydes and alkynes.
abstract: A single Cu(II) catalyst without the addition of ligand or base couples a diverse range of nitrogen sources with alkynes and aldehydes bearing alkyl, halogenated, silyl, aryl, and heteroaryl groups. The first example of a copper-catalyzed alkynylation involving p-toluenesulfonamide provides high yields of N-Ts-protected propargylamines. The superior activity of copper(II) triflate also allows this three-component alkynylation to incorporate a ketone.
authors.affiliation: Department of Chemistry, University of California, Riverside, California 92521, USA.
authors.forename: Courtney E
authors.initials: CE
authors.lastname: Meyet
authors.forename: Conor J
authors.initials: CJ
authors.lastname: Pierce
authors.forename: Catharine H
authors.initials: CH
authors.lastname: Larsen
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D007097:Imines; D003300:Copper; D009584:Nitrogen