title: In vitro antiplasmodial properties of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae).
abstract: The present study was conducted to investigate the in vitro antimalarial activity of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae). These two plants are used in Benin folk medicine to treat malaria and fever. Antimalarial activity was assayed on fresh clinical isolates of chloroquine resistant Plasmodium falciparum using the in vitro semi-microtest. The results revealed that the IC(50) varied from 1.55 to 22.36µg/ml. F. flavescens hydro methanol extract was more active than R. canthioides. The study demonstrated scientific rationale behind the traditional usage of these plants, however further bioactivity guided phytochemical analyses are necessary to identify the active principles.
authors.affiliation: Laboratoire de Microbiologie et des Technologies Alimentaires, Université d'Abomey-Calavi, Cotonou, Bénin.
authors.forename: Micheline
authors.initials: M
authors.lastname: Agassounon Djikpo-Tchibozo
authors.forename: Simplice D
authors.initials: SD
authors.lastname: Karou
authors.forename: Souleymane
authors.initials: S
authors.lastname: Sanon
authors.forename: Fatiou
authors.initials: F
authors.lastname: Toukourou
authors.forename: Comlan
authors.initials: C
authors.lastname: de Souza
mesh_terms: D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001541:Benin; D002738:Chloroquine / Q000627:therapeutic use; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy*; D016488:Medicine, African Traditional; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010963:Plasmodium falciparum / Q000187:drug effects*; D019666:Rubiaceae / Q000737:chemistry*; D031308:Salicaceae / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine