title: Microwave-assisted multicomponent reactions: rapid and regioselective formation of new extended angular fused aza-heterocycles.
abstract: A new multicomponent domino reaction for rapid and regioselective synthesis of highly functionalized benzo[h]naphtho[2,3-a]acridine-15,16(5H,14H)-diones has been established. The reaction can be conducted by using readily available and inexpensive substrates under microwave irradiation. The procedures are facile, avoiding timeconsuming and costly syntheses, tedious work-up and purifications of precursors as well as protection/deprotection of functional groups. This method is much more efficient due to short reaction times and easy work up. The resulting naphthoacridines have been readily converted into benzoquinoxaline-fused benzoquinoline analogues by treating with benzene-1,2-diamine under microwave irradiation. The structural assignment has been ambiguously confirmed by X-ray analysis. A new mechanism has been proposed for this new multicomponent domino process.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou, P.R. China.
authors.forename: Shu-Liang
authors.initials: SL
authors.lastname: Wang
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Ding
authors.initials: D
authors.lastname: Jie
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Xing-Han
authors.initials: XH
authors.lastname: Wang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D006571:Heterocyclic Compounds; D011804:Quinolines