title: 20q- clonality in a case of oral sweet syndrome and myelodysplasia.
abstract: We report the case of a patient with myelodysplasia who had Sweet syndrome of the oral cavity. An atypical myeloid immunophenotype was present in the gingival biopsy specimen and in a concurrent bone marrow specimen. Fluorescence in situ hybridization performed on the gingival biopsy specimen demonstrated the same del(20q) cytogenetic abnormality present in the bone marrow, confirming the presence of a clonally related myeloid proliferation in both tissues. This is the first reported case of Sweet syndrome and myelodysplasia in which the chromosomal abnormality was identified in the neutrophilic infiltrate, confirming the neutrophilic infiltrate to be clonally related to the underlying myeloid neoplasm.
authors.affiliation: University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Van Loon
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Gill
authors.forename: Patrick
authors.initials: P
authors.lastname: McMahon
authors.forename: Radhika
authors.initials: R
authors.lastname: Chigurupati
authors.forename: Imran
authors.initials: I
authors.lastname: Siddiqi
authors.forename: Lindy
authors.initials: L
authors.lastname: Fox
authors.forename: Lloyd
authors.initials: L
authors.lastname: Damon
authors.forename: Timothy H
authors.initials: TH
authors.lastname: McCalmont
authors.forename: Richard
authors.initials: R
authors.lastname: Jordan
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D005881:Gingiva / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D009504:Neutrophils / Q000473:pathology; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm