title: Thymidine kinase assay in canine lymphoma.
abstract: The aim of the study was to evaluate if thymidine kinase (TK) correlated with duration of first remission (DFR) or survival in dogs with lymphoma and if initial TK levels correlated with stage and substage; and also to assess if TK level at diagnosis correlated with immunophenotype. TK was assayed in 73 dogs with treatment naïve lymphoma, then again after treatment; 47% had an initial TK above the reference interval. Dogs with B-cell lymphoma had higher initial TK activities than dogs with T-cell lymphoma. TK levels were not higher in dogs with higher stage disease and TK activity prior to treatment was not associated with DFR or survival. Where TK was elevated at diagnosis, it fell into the reference range during remission. TK was normal in 53% dogs at diagnosis, which is higher than previously reported. Further studies are warranted to assess the utility of TK in dogs with lymphoma.
authors.affiliation: Small Animal Teaching Hospital, University of Liverpool, Wirral, UK. jelliott@liverpool.ac.uk
authors.forename: J W
authors.initials: JW
authors.lastname: Elliott
authors.forename: P
authors.initials: P
authors.lastname: Cripps
authors.forename: L
authors.initials: L
authors.lastname: Blackwood
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D016019:Survival Analysis; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D013937:Thymidine Kinase