title: Spectral features of electroencephalogram in characterizing various brain states under anesthesia.
abstract: The administration of the anesthetic agents is known to alter the electroencephalogram (EEG) signal significantly with the brain being their primary target. In this study, we analyzed the EEG recorded from six ASA I/II patients undergoing a 1-2 hour surgery. The EEG was collected before and during induction, maintenance and recovery of anesthesia using the 10/20 lead-system. A combination of fentanyl and propofol (± rocuronium) was used for induction and a Sevoflurane in air/O(2) mixture was administered through an endotracheal tube to achieve the steady minimum alveolar concentration (MAC). This study showed that 0 to 4 Hz signal power was most sensitive to the changes associated with induction of anesthesia whereas the 4 to 12 Hz power was important in classifying states during maintenance of anesthesia. Anesthesia also promoted heightened phase coherence in 8 to 16 Hz and 16 to 30 Hz ranges during maintenance and induction of anesthesia, respectively. Additionally, strong cross-frequency coupling between 7 to 20 Hz and 10 to 40 Hz was observed during anesthesia suggesting alteration of neural coding.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9 Canada. ellen.kang@utoronto.ca
authors.forename: Eunji E
authors.initials: EE
authors.lastname: Kang
authors.forename: Osbert C
authors.initials: OC
authors.lastname: Zalay
authors.forename: Hossam
authors.initials: H
authors.lastname: El Beheiry
authors.forename: Jean
authors.initials: J
authors.lastname: Wong
authors.forename: Martin
authors.initials: M
authors.lastname: del Campo
authors.forename: Peter L
authors.initials: PL
authors.lastname: Carlen
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakijan
mesh_terms: D000758:Anesthesia; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D006801:Humans