title: Cytokine network in psoriasis revisited.
abstract: Psoriasis is a chronic genetically determined, erythemato-squamous disease associated with many comorbidities. Evidence from clinical studies and experimental models support the concept that psoriasis is a T cell-mediated inflammatory skin disease and T helper (Th) cells - Th1, Th17 and Th22 - play an important role in the pathogenesis. Th1 cytokines IFNγ, IL-2, as well as Th17 cytokines IL-17A, IL-17F, IL-22, IL-26, and TNFα (Th1 and Th17 cytokine) are increased in serum and lesional skin. IL-22 produced by Th17 and new subset of T helper cells, Th22, is also increased within psoriatic lesions and in the serum. Other recently recognized cytokines of significant importance in psoriasis are IL-23, IL-20 and IL-15. The IL-23/Th17 pathway plays a dominant role in psoriasis pathogenesis. Currently due to enormous methodological progress, more and more clinical and histopathological psoriatic features could be explained by particular cytokine imbalance, which still is one of the most fascinating dermatological research fields stimulating new and new generations of researchers.
authors.affiliation: Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, ul. Radziwiłłowska 13, 20-080 Lublin, Poland. annamichalak@wp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Michalak-Stoma
authors.forename: Aldona
authors.initials: A
authors.lastname: Pietrzak
authors.forename: Jacek C
authors.initials: JC
authors.lastname: Szepietowski
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska-Janowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Paszkowski
authors.forename: Grażyna
authors.initials: G
authors.lastname: Chodorowska
mesh_terms: D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D006801:Humans; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines