title: Novel isocyanide-based three-component synthesis of substituted 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in water.
abstract: Three-component reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, dialkyl acetylenedicarboxylates and isocyanides in water was described as efficient and green synthetic procedure for preparation of 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in excellent yield. In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)- 1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran. The structure of this compound was determined by 1H, 13C-NMR and IR spectroscopy and confirmed by X-ray diffraction analysis. This procedure provides rapid access to novel and diversely substituted 9H-furo[2,3-f]chromene-8,9-dicarboxylate derivatives.
authors.affiliation: Department of Chemistry, Gonbad Kavous University, Gonbad, Iran. f_rostami_ch@yahoo.com
authors.forename: Faramarz
authors.initials: F
authors.lastname: Rostami-Charati
authors.forename: Zinatossadat
authors.initials: Z
authors.lastname: Hossaini
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Khalilzadeh
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis; D003486:Cyanides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D036901:Petasites / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001578:Benzopyrans; D002264:Carboxylic Acids; D003486:Cyanides; D010936:Plant Extracts; D014867:Water