title: Formulation of the multi-hit model with a non-Poisson distribution of hits.
abstract: OBJECTIVE
  We proposed a formulation of the multi-hit single-target model in which the Poisson distribution of hits was replaced by a combination of two distributions: one for the number of particles entering the target and one for the number of hits a particle entering the target produces. Such an approach reflects the fact that radiation damage is a result of two different random processes: particle emission by a radiation source and interaction of particles with matter inside the target.
  
  
  METHODS
  Poisson distribution is well justified for the first of the two processes. The second distribution depends on how a hit is defined. To test our approach, we assumed that the second distribution was also a Poisson distribution. The two distributions combined resulted in a non-Poisson distribution. We tested the proposed model by comparing it with previously reported data for DNA single- and double-strand breaks induced by protons and electrons, for survival of a range of cell lines, and variation of the initial slopes of survival curves with radiation quality for heavy-ion beams.
  
  
  RESULTS
  Analysis of cell survival equations for this new model showed that they had realistic properties overall, such as the initial and high-dose slopes of survival curves, the shoulder, and relative biological effectiveness (RBE) In most cases tested, a better fit of survival curves was achieved with the new model than with the linear-quadratic model. The results also suggested that the proposed approach may extend the multi-hit model beyond its traditional role in analysis of survival curves to predicting effects of radiation quality and analysis of DNA strand breaks.
  
  
  CONCLUSIONS
  Our model, although conceptually simple, performed well in all tests. The model was able to consistently fit data for both cell survival and DNA single- and double-strand breaks. It correctly predicted the dependence of radiation effects on parameters of radiation quality.
authors.affiliation: Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Oleg.Vassiliev@albertahealthservices.ca
authors.forename: Oleg N
authors.initials: ON
authors.lastname: Vassiliev
mesh_terms: D002470:Cell Survival / Q000235:genetics / Q000528:radiation effects*; D053903:DNA Breaks, Double-Stranded; D053904:DNA Breaks, Single-Stranded; D004583:Electrons / Q000627:therapeutic use; D016014:Linear Models; D008954:Models, Biological; D009010:Monte Carlo Method; D016012:Poisson Distribution; D061766:Proton Therapy; D012062:Relative Biological Effectiveness; D011522:Protons
chemical_list: D011522:Protons