title: Rhabdomyolysis:  rare complications with a difficult prognosis in the course of anticancer treatment.
abstract: Rhabdomyolysis refers to a number of clinical and biochemical symptoms, which result from the destruction of skeletal muscles. The following triad of symptoms is considered typical: myalgia, muscle weakness, and dark urine. The most common reasons for rhabdomyolysis in children are infections. It has also been reported that rhabdomyolysis may be caused by chemotherapy drugs. The most difficult complication of rhabdomyolysis is renal failure. The authors present a 17-year-old boy diagnosed with Ewing sarcoma and a 16-year-old boy suffering from acute leukemia, both with rhabdomyolysis developed in the course of infection caused by Clostridium difficile, and drug-induced neutropenia.
authors.affiliation: Department of Pediatric Oncology, Haematology and Chemotherapy, Medical University of Silesia, Upper Silesia Children's Care Heatlh Centre, Katowice, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Sobol
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Musioł
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mizia-Malarz
authors.forename: Weronika
authors.initials: W
authors.lastname: Stolpa
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Krupa
authors.forename: Halina
authors.initials: H
authors.lastname: Woś
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D016360:Clostridioides difficile; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D012512:Sarcoma, Ewing / Q000188:drug therapy*