title: The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response.
abstract: DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging. It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair. Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks (DSBs) in yeast. Here, we show that the human nucleoporin 153 (NUP153) has a role in repair of DSBs and in the activation of DNA damage checkpoints. We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, CU de Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Lemaître
authors.forename: B
authors.initials: B
authors.lastname: Fischer
authors.forename: A
authors.initials: A
authors.lastname: Kalousi
authors.forename: A-S
authors.initials: AS
authors.lastname: Hoffbeck
authors.forename: J
authors.initials: J
authors.lastname: Guirouilh-Barbat
authors.forename: O D
authors.initials: OD
authors.lastname: Shahar
authors.forename: D
authors.initials: D
authors.lastname: Genet
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: P
authors.initials: P
authors.lastname: Betrand
authors.forename: B
authors.initials: B
authors.lastname: Lopez
authors.forename: L
authors.initials: L
authors.lastname: Brino
authors.forename: E
authors.initials: E
authors.lastname: Soutoglou
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002470:Cell Survival / Q000235:genetics; D053903:DNA Breaks, Double-Stranded / Q000187:drug effects; D059766:DNA End-Joining Repair; D004260:DNA Repair / Q000502:physiology*; D059765:Homologous Recombination; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D034622:RNA Interference / Q000187:drug effects; D000071857:Tumor Suppressor p53-Binding Protein 1
chemical_list: D000903:Antibiotics, Antineoplastic; D047908:Intracellular Signaling Peptides and Proteins; C079377:NUP153 protein, human; D028861:Nuclear Pore Complex Proteins; C498301:TP53BP1 protein, human; D000071857:Tumor Suppressor p53-Binding Protein 1; D001761:Bleomycin