title: Chromosome 2p14 is linked to susceptibility to leprosy.
abstract: BACKGROUND
  A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established.
  
  
  METHODS
  A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1.
  
  
  RESULTS
  Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26.
  
  
  CONCLUSIONS
  A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China.
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Hui-Qi
authors.initials: HQ
authors.lastname: Low
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wang
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xi'an
authors.initials: X
authors.lastname: Fu
authors.forename: Gongqi
authors.initials: G
authors.lastname: Yu
authors.forename: Mingfei
authors.initials: M
authors.lastname: Chen
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Yan
authors.forename: Shumin
authors.initials: S
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Furen
authors.initials: F
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D002877:Chromosomes, Human; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007918:Leprosy / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide