title: Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C.
abstract: Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients. However, central nervous system (CNS) involvement is uncommon, especially in cryoglobulin-negative subjects. We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia. Significant improvement was observed after antiviral therapy. We discuss the spectrum of neurological manifestations of HCV infection and review the literature.
authors.affiliation: Division of Gastroenterology, Hepatitis Section, Federal University of Sao Paulo, 04037-003 Sao Paulo, Brazil. roberto.jcf@uol.com.br
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Carvalho-Filho
authors.forename: Janaína Luz
authors.initials: JL
authors.lastname: Narciso-Schiavon
authors.forename: Luciano H L
authors.initials: LH
authors.lastname: Tolentino
authors.forename: Leonardo L
authors.initials: LL
authors.lastname: Schiavon
authors.forename: Maria Lucia G
authors.initials: ML
authors.lastname: Ferraz
authors.forename: Antonio Eduardo B
authors.initials: AE
authors.lastname: Silva
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011115:Polyneuropathies / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012367:RNA, Viral / Q000097:blood; D020293:Vasculitis, Central Nervous System / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral