title: IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data.
abstract: The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human genome. Illumina Methylation Analyzer (IMA) is a computational package designed to automate the pipeline for exploratory analysis and summarization of site-level and region-level methylation changes in epigenetic studies utilizing the 450K DNA methylation microarray. The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions.
  
  
  BACKGROUND
  IMA is implemented in the R language and is freely available from http://www.rforge.net/IMA.
authors.affiliation: Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hu
authors.forename: Lara E
authors.initials: LE
authors.lastname: Sucheston
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Higgins
authors.forename: Christine B
authors.initials: CB
authors.lastname: Ambrosone
authors.forename: Candace S
authors.initials: CS
authors.lastname: Johnson
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Smiraglia
authors.forename: Song
authors.initials: S
authors.lastname: Liu
mesh_terms: D018899:CpG Islands; D019175:DNA Methylation; D015894:Genome, Human; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software