title: Neurospecific proteins in the serum of patients with brain tumors.
abstract: Neurospecific proteins S-100 and GFAP were measured in the serum of 145 patients with neural tumors and 69 healthy individuals. In patients with glyoblastomas, the concentrations of S-100 and GFAP were significantly higher than in patients with anaplastic astrocytomas, benign meningiomas, and brain metastases and in healthy individuals. Serum S-100 concentrations in patients with anaplastic astrocytomas, benign meningiomas, and brain metastases were similar; significant difference from the control was found only for patients with cerebral metastases. A specific feature of GFAP was high incidence of its detection in patients with glioblastomas (83%) compared to other groups of patients with neural tumors and healthy volunteers who demonstrated practically zero level of this protein. These findings attest to the possibility of using S-100 as an additional biochemical criterion of brain involvement in tumor patients and GFAP as a glioblastoma marker.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. biochimia@mtu-net.ru
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: M G
authors.initials: MG
authors.lastname: Toms
authors.forename: E E
authors.initials: EE
authors.lastname: Popova
authors.forename: Y V
authors.initials: YV
authors.lastname: Bondarenko
authors.forename: V B
authors.initials: VB
authors.lastname: Krat
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008579:Meningioma / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*; D055815:Young Adult
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009363:Neoplasm Proteins; D009418:S100 Proteins