title: Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient.
abstract: We evaluated the pharmacokinetics of linezolid in the case of an obese Japanese patient (body weight 116 kg; body mass index 37 kg/m(2)). Linezolid was administered at a dose of 600 mg by intravenous drip infusion for 60-90 min at 12-h intervals. The results showed increased clearance of linezolid and a reduced serum concentration compared to population pharmacokinetic parameters, with trough levels below the 90% minimum inhibitory concentration. However, linezolid was effective for improving lung infection and inflammation in our patient, which may be due to its particularly effective transfer into lung tissues. Linezolid undergoes slow non-enzymatic oxidation in vivo that may be increased in obese patients, and this may account for the greater clearance. Our findings are useful for the planning of linezolid therapy in obese patients.
authors.affiliation: Department of Pharmacy, Sasebo Chuo Hospital, Nagasaki, Japan. yas_tsuji@hakujyujikai.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Kana
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sadoh
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Seisaburo
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Morita
authors.forename: Eiji
authors.initials: E
authors.lastname: Yukawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kamimura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Karube
mesh_terms: D000081:Acetamides / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007564:Japan; D000069349:Linezolid; D008171:Lung Diseases / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D009765:Obesity / Q000378:metabolism*; D023303:Oxazolidinones / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid