title: Strontium ranelate prevents bone loss in a rat model of localized muscle paralysis.
abstract: Twenty-one 3.5-month-old female Sprague-Dawley rats were randomly assigned to three groups: BTX group, in which each rat received a single intramuscular injection of 2 U of Clostridium botulinum toxin (BTX) in the quadriceps femoris muscle of the right hind limb; BTX + SR group, in which each rat received a BTX injection and a dose of strontium ranelate (dose level of 625 mg/kg/day); and the control group. All the rats were killed at 9 weeks post-treatment. It was showed that BTX-induced rats a rapid loss of body weight in the first 3 weeks, after which their body weight showed a slow increase similar to that observed in the control rats. The net body weight loss was mainly attributed to muscle atrophy. BTX caused remarkable bone degradation in either the trabecular bone or the cortical bone of the disuse femur. The deteriorations in the bone mass and bone microstructure were locally limited and could be prevented by strontium ranelate treatment. Biomechanical analysis showed that strontium ranelate treatment improved the mechanical performance of the tibia in BTX-treated rats. It was showed that a clinical-corresponding dose of strontium ranelate could prevent bone loss in long-term immobilized rats.
authors.affiliation: Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, 410011 Hunan, People's Republic of China.
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Sheng
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ma
authors.forename: Dejun
authors.initials: D
authors.lastname: Tong
authors.forename: De-Yu
authors.initials: DY
authors.lastname: Fang
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Liang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Er-Yuan
authors.initials: EY
authors.lastname: Liao
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001905:Botulinum Toxins / Q000633:toxicity; D004195:Disease Models, Animal; D055119:Elastic Modulus; D005260:Female; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D010243:Paralysis / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013876:Thiophenes / Q000008:administration & dosage*; D055114:X-Ray Microtomography
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D001905:Botulinum Toxins