title: Comparison of performance parameters for conventional and localized surface plasmon resonance graphene biosensors.
abstract: This paper investigates the enhancement of the sensitivity and adsorption efficiency of a localized surface plasmon resonance (LSPR) biosensor that includes a layer of graphene sheet on top of the gold layer. For this purpose, biomolecular interactions of biotin-streptavidin with the graphene layer on the gold thin film are monitored. The performance of the LSPR graphene biosensor is theoretically and numerically assessed in terms of sensitivity and adsorption efficiency under varying conditions, including the thickness of biomolecule layer, number of graphene layers and operating wavelength. Enhanced sensitivity and improved adsorption efficiency are obtained for the LSPR graphene biosensor in comparison with its conventional counterpart. It is found that the LSPR graphene biosensor has better sensitivity with lower operating wavelength and larger number of graphene layers.
authors.affiliation: School of Engineering, Deakin University, Geelong, Victoria 3217, Australia. msi@deakin.edu.au
authors.forename: Md Saiful
authors.initials: MS
authors.lastname: Islam
authors.forename: Abbas Z
authors.initials: AZ
authors.lastname: Kouzani
authors.forename: Xiujuan J
authors.initials: XJ
authors.lastname: Dai
authors.forename: Wojtek P
authors.initials: WP
authors.lastname: Michalski
authors.forename: Hamid
authors.initials: H
authors.lastname: Gholamhosseini
mesh_terms: D001704:Biopolymers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D007118:Immunoassay / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D001704:Biopolymers; D006108:Graphite