title: Facilitated self-assembly of novel dendron-based copolymers.
abstract: Self-assembly of newly synthesized dendron-based amphiphilic copolymers with controlled hydrophilic-lipophilic balances has been investigated to evaluate their potential as a novel nanocarrier. The hydroxyl-terminated polyester dendron (G3) bearing a focal alkyne moiety was used to mediate the combination of poly(s-caprolactone) (PCL) with multiple polyethylene glycol (PEG) moieties. Four types of PCL-G3-mPEG with different block lengths were prepared and their structures were confirmed by (1)H NMR, FT-IR, and GPC. Critical micelle concentration (CMC) values varied from 6.50 × 10(-8) to 3.52 × 10(-7) M, which were lower than those reported for linear PCL-mPEG. TEM revealed that all PCL-G3-mPEG micelles were spherical with an average diameter of 20 nm. The drug release profile for each PCL-G3-mPEG was investigated by loading indomethacin (IMC), as a model drug, within the micelles. IMC was released in a controlled manner over 72 hours. Synthesized copolymers used in this study were also found to be non-cytotoxic at concentrations up to 100 μM. The low CMC, along with the controlled morphology, release profile and biocompatibility, all demonstrate the potential of the dendron-based micelles as a novel nanocarrier.
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL 60612, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Pearson
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Bae
authors.forename: Suhair
authors.initials: S
authors.lastname: Sunoqrot
authors.forename: Sayam
authors.initials: S
authors.lastname: Uddin
authors.forename: Seungpyo
authors.initials: S
authors.lastname: Hong
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002625:Chemistry, Organic / Q000379:methods*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D050091:Dendrimers; D008823:Micelles; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D007213:Indomethacin