title: Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.
abstract: To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode; unprocessed radiofrequency data were obtained with pulsed wave Doppler from the aorta and/or LV during Sonazoid infusion. Subharmonic data (in dB) were extracted and processed. Calibration factor (mm Hg/dB) from the aortic pressure was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mm Hg when estimating pressures using the aortic calibration factor, and were higher (0.64 to 8.98 mm Hg) using a mean aortic calibration factor. Subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.
authors.affiliation: Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Jaydev K
authors.initials: JK
authors.lastname: Dave
authors.forename: Valgerdur G
authors.initials: VG
authors.lastname: Halldorsdottir
authors.forename: John R
authors.initials: JR
authors.lastname: Eisenbrey
authors.forename: Joel S
authors.initials: JS
authors.lastname: Raichlen
authors.forename: Ji-Bin
authors.initials: JB
authors.lastname: Liu
authors.forename: Maureen E
authors.initials: ME
authors.lastname: McDonald
authors.forename: Kris
authors.initials: K
authors.lastname: Dickie
authors.forename: Shumin
authors.initials: S
authors.lastname: Wang
authors.forename: Corina
authors.initials: C
authors.lastname: Leung
authors.forename: Flemming
authors.initials: F
authors.lastname: Forsberg
mesh_terms: D000818:Animals; D001011:Aorta / Q000000981:diagnostic imaging; D001794:Blood Pressure; D002138:Calibration; D003287:Contrast Media; D004285:Dogs; D018619:Echocardiography, Doppler, Pulsed / Q000592:standards; D005290:Ferric Compounds; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D007501:Iron; D045423:Microbubbles; D023421:Models, Animal; D010087:Oxides; D011237:Predictive Value of Tests; D013997:Time Factors; D016277:Ventricular Function, Left; D017725:Ventricular Pressure
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron