title: Cu-catalyzed asymmetric [3+2] cycloaddition of α-iminoamides with activated olefins.
abstract: A variety of 2-amido pyrrolidines, including Weinreb-type amides, have been prepared with very high exo diastereoselectivity and enantioselectivitiy in the reaction of α-iminoamides with activated alkenes catalyzed by Cu(I)-Segphos ligands.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: González-Esguevillas
authors.forename: Javier
authors.initials: J
authors.lastname: Adrio
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000577:Amides; D007097:Imines; D011759:Pyrrolidines; D003300:Copper