title: Pathogenicity of a natural reassortant hantavirus CGRn9415 in newborn rats and newborn mice.
abstract: To better understand the pathogenicity and infectivity of a natural reassortant CGRn9415 generated from Hantaan virus (HTNV) and Seoul virus (SEOV), CGRn9415, HTNV 76-118 and SEOV L99 were used to infect newborn Kunming (KM) mice and newborn Wistar rats. In KM mice, there was no statistical difference between the death rate with CGRn9415 and that of L99, while 76-118 killed all mice even at low dosage; CGRn9415 killed all infected rats similar to L99 at the dosage of 10(5) f.f.u., while no death occurred in rats infected with 76-118 even as high as 2 × 10(5) f.f.u., suggesting that the reassortant CGRn9415 possesses similar pathogenicity as L99. Furthermore, the reassortant CGRn9415 could establish a persistent infection in both KM mice and Wistar rats more easily than 76-118 or L99. These data suggest that the reassorted hantavirus behaves more like SEOV as far as the pathogenicity is concerned.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
authors.affiliation: Medical Institute of Nanjing Army, Nanjing, PR China.|State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Li
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Gao-Yu
authors.initials: GY
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Guo
authors.affiliation: Medical Institute of Nanjing Army, Nanjing, PR China.
authors.forename: Xiao-Zhao
authors.initials: XZ
authors.lastname: Deng
authors.affiliation: Medical Institute of Nanjing Army, Nanjing, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, 430070 Wuhan, PR China.|Department of Pathology, University of Georgia, Athens, GA 30602, USA.
authors.forename: Zhen F
authors.initials: ZF
authors.lastname: Fu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Xin-Cheng
authors.initials: XC
authors.lastname: Qin
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Liuzi 5, 102206 Beijing, PR China.
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018063:Hantaan virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000401:mortality / Q000821:virology*; D006801:Humans; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D029263:Seoul virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D016019:Survival Analysis