title: Comparison of superimposed high-frequency jet ventilation with conventional jet ventilation for laryngeal surgery.
abstract: BACKGROUND
  New ventilators have simplified the use of supraglottic superimposed high-frequency jet ventilation (SHFJV(SG)), but it has not been systematically compared with other modes of jet ventilation (JV) in humans. We sought to investigate whether SHFJV(SG) would provide more effective ventilation compared with single-frequency JV techniques.
  
  
  METHODS
  A total of 16 patients undergoing minor laryngeal surgery under general anaesthesia were included. In each patient, four different JV techniques were applied in random order for 10-min periods: SHFJV(SG), supraglottic normal frequency (NFJV(SG)), supraglottic high frequency (HFJV(SG)), and infraglottic high-frequency jet ventilation (HFJV(IG)). Chest wall volume variations were continuously measured with opto-electronic plethysmography (OEP), intratracheal pressure was recorded and blood gases were measured.
  
  
  RESULTS
  Chest wall volumes were normalized to NFJV(SG) end-expiratory level. The increase in end-expiratory chest wall volume (EEV(CW)) was 239 (196) ml during SHFJV(SG) (P<0.05 compared with NFJV(SG)). EEV(CW) was 148 (145) and 44 (106) ml during HFJV(SG) and HFJV(IG), respectively (P<0.05 compared with SHFJV(SG)). Tidal volume (V(T)) during SHFJV(SG) was 269 (149) ml. V(T) was 229 (169) ml (P=1.00 compared with SHFJV(SG)), 145 (50) ml (P<0.05), and 110 (33) ml (P<0.01) during NFJV(SG), HFJV(SG), and HFJV(IG), respectively. Intratracheal pressures corresponded well to changes in both EEV(CW) and V(T). All JV modes resulted in adequate oxygenation. However, was lowest during HFJV(SG) [4.3 (1.3) kPa; P<0.01 compared with SHFJV(SG)].
  
  
  CONCLUSIONS
  SHFJV(SG) was associated with increased EEV(CW) and V(T) compared with the three other investigated JV modes. All four modes provided adequate ventilation and oxygenation, and thus can be used for uncomplicated laryngeal surgery in healthy patients with limited airway obstruction.
authors.affiliation: Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Sjukhusvägen 1, Entrance 70, S-75185 Uppsala, Sweden. robert.leiter@surgsci.uu.se
authors.forename: R
authors.initials: R
authors.lastname: Leiter
authors.forename: A
authors.initials: A
authors.lastname: Aliverti
authors.forename: R
authors.initials: R
authors.lastname: Priori
authors.forename: P
authors.initials: P
authors.lastname: Staun
authors.forename: A
authors.initials: A
authors.lastname: Lo Mauro
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: P
authors.initials: P
authors.lastname: Frykholm
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006611:High-Frequency Jet Ventilation / Q000379:methods*; D006801:Humans; D007828:Laryngoscopy / Q000379:methods*; D007830:Larynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods; D013990:Tidal Volume