title: Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.
abstract: A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Sanae
authors.initials: S
authors.lastname: Shirotsuki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Iwata
authors.forename: Chika
authors.initials: C
authors.lastname: Kageyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozaki
authors.forename: Eric R O
authors.initials: ER
authors.lastname: Siwu
authors.forename: Satoru
authors.initials: S
authors.lastname: Tamura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Douke
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Murakami
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Onoe
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukase
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis; D057930:Click Chemistry / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D051380:GRB2 Adaptor Protein; D006801:Humans; D018716:Molecular Mimicry; D010455:Peptides / Q000138:chemical synthesis*; D018909:src Homology Domains
chemical_list: D000970:Antineoplastic Agents; D051380:GRB2 Adaptor Protein; D010455:Peptides