title: Live cell luminescence imaging as a function of delivery mechanism.
abstract: Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH-sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties.
authors.affiliation: Department of Biomedical Science, The University of Sheffield, Sheffield S10 7TN, UK.
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Tian
authors.forename: Martin R
authors.initials: MR
authors.lastname: Gill
authors.forename: Irene
authors.initials: I
authors.lastname: Cantón
authors.forename: Jim A
authors.initials: JA
authors.lastname: Thomas
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
mesh_terms: D001692:Biological Transport; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D006801:Humans; D049449:Luminescence; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D057054:Molecular Imaging; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA