title: Screening and characterization of a chemical regulator for plant disease resistance.
abstract: Plants activate systemic acquired resistance (SAR), a form of long-lasting induced defense, to confer protection against a broad spectrum of pathogens. SAR induction is associated with the salicylic acid (SA)-mediated defense signaling networks. For detailed understandings of the SA-mediated signaling of SAR induction, we screened chemical inhibitors that block SA-mediated signaling from a 9600-compound chemical library. As a result, we identified one candidate chemical, 4-phenyl-2-{[3-(tri-fluoromethyl)anilino]methylidene}cyclohexane-1,3-dione (PAMD), that suppresses the expression of pathogenesis-related (PR) gene. PAMD also down-regulates SA-induced gene expression and enhances susceptibility to pathogen.
authors.affiliation: Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Seo
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakamura
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Tadao
authors.initials: T
authors.lastname: Asami
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry* / Q000494:pharmacology; D001681:Biological Assay; D003510:Cyclohexanes / Q000737:chemistry* / Q000494:pharmacology; D060467:Disease Resistance; D005786:Gene Expression Regulation / Q000187:drug effects; D015394:Molecular Structure; D010935:Plant Diseases / Q000517:prevention & control; D020156:Salicylic Acid / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects; D054852:Small Molecule Libraries
chemical_list: C572262:4-phenyl-2-((3-(tri-fluoromethyl)anilino)methylidene)cyclohexane-1,3-dione; D000814:Aniline Compounds; D003510:Cyclohexanes; D054852:Small Molecule Libraries; D020156:Salicylic Acid