title: Epidemiology, risk factors and management of paediatric diabetic retinopathy.
abstract: Diabetic retinopathy (DR), a common complication of both type 1 and type 2 diabetes, is rarely expressed at a level greater than background retinopathy during childhood and adolescence. Epidemiological studies in paediatric diabetic patients together with data from the Diabetes Control and Complications Trial have demonstrated the importance of glycaemic control in delaying or preventing the development of DR; thus, the incidence of DR has declined somewhat over the past two decades. Both prepubertal and postpubertal years with diabetes contribute to the overall probability of DR development. In addition to duration of disease and degree of glycaemic control, other risk factors for DR development include elevated blood pressure, lipid profiles, serum levels of advanced glycation endproducts, evidence for early stage atherosclerosis, increased calibre of retinal blood vessels and several genetic factors, such as enzymes involved in glucose and lipid metabolism. Annual screening is recommended, with mydriatic stereoscopic fundus photography being the most sensitive detection method. Both pathophysiology and treatment in paediatric populations are essentially the same as described for adult populations, with treatment usually not required until adulthood is reached.
authors.affiliation: Pfizer Inc, New York, NY 10017, USA. marla.b.sultan@pfizer.com
authors.forename: Marla B
authors.initials: MB
authors.lastname: Sultan
authors.forename: Carla
authors.initials: C
authors.lastname: Starita
authors.forename: Kui
authors.initials: K
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D003941:Diagnostic Techniques, Ophthalmological; D038321:Glycemic Index; D006801:Humans; D015994:Incidence; D007223:Infant; D012307:Risk Factors