title: Target motion predictions for pre-operative planning during needle-based interventions.
abstract: During biopsies, breast tissue is subjected to displacement upon needle indentation, puncture, and penetration. Thus, accurate needle placement requires pre-operative predictions of the target motions. In this paper, we used ultrasound elastography measurements to non-invasively predict elastic properties of breast tissue phantoms. These properties were used in finite element (FE) models of indentation of breast soft tissue phantoms. To validate the model predictions of target motion, experimental measurements were carried out. Breast tissue phantoms with cubic and hemispherical geometries were manufactured and included materials with different elastic properties to represent skin, adipose tissue, and lesions. Ultrasound was used to track the displacement of the target (i.e., the simulated lesion) during indentation. The FE model predictions were compared with ultrasound measurements for cases with different boundary conditions and phantom geometry. Maximum errors between measured and predicted target motions were 12% and 3% for the fully supported and partially supported cubic phantoms at 6.0 mm indentation, respectively. Further, FE-based parameter sensitivity analysis indicated that increasing skin elastic modulus and reducing the target depth location increased the target motion. Our results indicate that with a priori knowledge about the geometry, boundary conditions, and linear elastic properties, indentation of breast tissue phantoms can be accurately predicted with FE models. FE models for pre-operative planning in combination with robotic needle insertions, could play a key role in improving lesion targeting for breast biopsies.
authors.affiliation: MIRA–Institute of Biomedical Technology and Technical Medicine, Control Engineering Group, University of Twente, The Netherlands. s.misra@utwente.nl
authors.forename: Jorn
authors.initials: J
authors.lastname: op den Buijs
authors.forename: Momen
authors.initials: M
authors.lastname: Abayazid
authors.forename: Chris L
authors.initials: CL
authors.lastname: de Korte
authors.forename: Sarthak
authors.initials: S
authors.lastname: Misra
mesh_terms: D000465:Algorithms; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D003198:Computer Simulation; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008954:Models, Biological; D009038:Motion; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000295:instrumentation / Q000379:methods; D016217:Ultrasonography, Mammary / Q000295:instrumentation / Q000379:methods*