title: Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection.
abstract: Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.
authors.affiliation: Department of Anatomy, Shahid Beheshti Medical University, Velenjak, Tehran, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Heidari
authors.forename: Marefat Ghaffari
authors.initials: MG
authors.lastname: Novin
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ahmadi
authors.forename: Mehran
authors.initials: M
authors.lastname: Khorshid
authors.forename: Tohid
authors.initials: T
authors.lastname: Najafi
authors.forename: Aidin
authors.initials: A
authors.lastname: Molouki
authors.forename: Saghar
authors.initials: S
authors.lastname: Salehpour
authors.forename: Mojgan
authors.initials: M
authors.lastname: Bandehpour
authors.forename: Matineh
authors.initials: M
authors.lastname: Heidari
authors.forename: Eimi
authors.initials: E
authors.lastname: Sato