title: Lipophilic compound-mediated gene expression and implication for intervention in reactive oxygen species (ROS)-related diseases: mini-review.
abstract: In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
authors.affiliation: Department of Nutrition, University of Nevada, Reno, Nevada 89557-0208, USA. yukiko@cabnr.unr.edu
authors.forename: Yukiko K
authors.initials: YK
authors.lastname: Nakamura
authors.forename: Stanley T
authors.initials: ST
authors.lastname: Omaye
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D050197:Atherosclerosis / Q000517:prevention & control; D005786:Gene Expression Regulation / Q000187:drug effects; D006293:Health Promotion; D006801:Humans; D007249:Inflammation; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D044243:Linoleic Acids, Conjugated; D017382:Reactive Oxygen Species; D014810:Vitamin E