title: What a nostril knows: olfactory nerve-evoked AMPA responses increase while NMDA responses decrease at 24-h post-training for lateralized odor preference memory in neonate rat.
abstract: Increased AMPA signaling is proposed to mediate long-term memory. Rat neonates acquire odor preferences in a single olfactory bulb if one nostril is occluded at training. Memory testing here confirmed that only trained bulbs support increased odor preference at 24 h. Olfactory nerve field potentials were tested at 24 h in slices from trained and untrained bulbs. A larger AMPA component and a smaller NMDA component characterized responses in the bulb receiving odor preference training. Field potential changes were not seen in a bulbar region separate from the lateral odor-encoding area. These results support models in which memory is mediated by increased olfactory nerve-mitral cell AMPA signaling, and memory stability is promoted by decreased NMDA-mediated signaling.
authors.affiliation: Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X9.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yuan
authors.forename: Carolyn W
authors.initials: CW
authors.lastname: Harley
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000367:Age Factors; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001703:Biophysics; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D066298:In Vitro Techniques; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate / Q000378:metabolism*; D009666:Nose / Q000294:innervation*; D009812:Odorants; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D009832:Olfactory Nerve / Q000502:physiology*; D009833:Olfactory Pathways / Q000187:drug effects / Q000502:physiology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D018683:Excitatory Amino Acid Agents; D011810:Quinoxalines; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D013779:Tetrodotoxin; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid