title: Intramolecular folding in three tandem guanine repeats of human telomeric DNA.
abstract: Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats.
authors.affiliation: Department of Chemistry & Biochemistry, Kent State University, Kent, OH 44242, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Koirala
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mashimo
authors.forename: Yuta
authors.initials: Y
authors.lastname: Sannohe
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Yu
authors.forename: Hanbin
authors.initials: H
authors.lastname: Mao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D016615:Telomere / Q000737:chemistry*
chemical_list: D006147:Guanine; D004247:DNA