title: Local but not systemic capillary lactate is a reperfusion biomarker in experimental acute limb ischaemia.
abstract: BACKGROUND
  Systemic capillary lactate, an end product of cellular anaerobic metabolism, has not established credibility in monitoring limb reperfusion. We assessed, in mice, whether local capillary lactate, arising from the reperfused limb, might be a relevant biomarker of reperfusion.
  
  
  METHODS
  Systemic and local capillary lactate were sampled in the non-ischaemic and in the ischaemic limb. Only local lactate concentrations significantly increased after 2 h of ischaemia and decreased after reperfusion.
  
  
  CONCLUSIONS
  Local, but not systemic, capillary lactate appeared as a potential reperfusion biomarker in this experimental acute limb ischaemia model.
authors.affiliation: Pôle Anesthésie Réanimation Chirurgicale, SAMU, Hôpitaux Universitaires de Strasbourg, 1 avenue Molière, Strasbourg, France.
authors.forename: E
authors.initials: E
authors.lastname: Noll
authors.forename: J
authors.initials: J
authors.lastname: Bouitbir
authors.forename: O
authors.initials: O
authors.lastname: Collange
authors.forename: J
authors.initials: J
authors.lastname: Zoll
authors.forename: A L
authors.initials: AL
authors.lastname: Charles
authors.forename: F
authors.initials: F
authors.lastname: Thaveau
authors.forename: P
authors.initials: P
authors.lastname: Diemunsch
authors.forename: B
authors.initials: B
authors.lastname: Geny
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002196:Capillaries / Q000378:metabolism*; D006614:Hindlimb / Q000098:blood supply*; D007511:Ischemia / Q000097:blood* / Q000628:therapy*; D019344:Lactic Acid / Q000097:blood*; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism*; D015424:Reperfusion
chemical_list: D015415:Biomarkers; D019344:Lactic Acid