title: Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells.
abstract: Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a new drug delivery system, in which drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlled means for enhanced delivery of one or more agents stably associated with the liposomes.
authors.affiliation: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
authors.forename: Faina
authors.initials: F
authors.lastname: Karchemski
authors.forename: Daniel
authors.initials: D
authors.lastname: Zucker
authors.forename: Yechezkel
authors.initials: Y
authors.lastname: Barenholz
authors.forename: Oren
authors.initials: O
authors.lastname: Regev
mesh_terms: D018929:Cell Culture Techniques; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020285:Cryoelectron Microscopy; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry*; D004339:Drug Compounding; D006801:Humans; D008081:Liposomes; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D037742:Nanotubes, Carbon / Q000009:adverse effects / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations