title: A simple and effective approach to the synthesis of isoquinoline derivatives under solvent-free conditions.
abstract: An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50°C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.
authors.affiliation: Department of Chemistry, Qaemshahr Branch, Islamic Azad University, P.O. Box 163, Qaemshahr, Iran.
authors.forename: Zinatossadat
authors.initials: Z
authors.lastname: Hossaini
authors.forename: Faramarz
authors.initials: F
authors.lastname: Rostami-Charati
authors.forename: Somayeh
authors.initials: S
authors.lastname: Firoziyan
authors.forename: Maryam
authors.initials: M
authors.lastname: Sabbaghan
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Khalilzadeh
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D007212:Indolizines; D007546:Isoquinolines