title: Cationic ruthenium(II) catalysts for oxidative C-H/N-H bond functionalizations of anilines with removable directing group: synthesis of indoles in water.
abstract: Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Lygin
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D002412:Cations; D007211:Indoles; D014867:Water; D012428:Ruthenium; C023650:aniline