title: Prognostic value of Helicobacter pylori sinonasal colonization for efficacy of endoscopic sinus surgery.
abstract: Compared with rhinologic patients without chronic rhinosinusitis (CRS), a higher prevalence of sinonasal Helicobacter pylori (HP) in patients with CRS was found. This study investigated if HP sinonasal colonization has a prognostic value for efficacy of functional endoscopic sinus surgery (FESS). Nasal polyps of 40 patients with CRS, undergoing FESS, were analyzed for presence of HP using immunohistochemistry (IHC). Patients were categorized as to whether the IHC was positive (HP+ group) or negative (HP- group). HP+ group and HP- group were compared according to the nasal polyp eosinophil density, and to the improvement (difference between pre- and post-operative scores) of the subjective symptom scores, and the nasal endoscopic scores. Nasal polyps in 28 (70%) patients were positive for HP. There were no significant differences between HP+ group and HP- group comparing the eosinophils, and the improvement of the single symptom and the total symptom scores. HP+ group had significantly greater improvement of the nasal endoscopic scores (F[1.38] = 6.212; P = 0.017). There is no influence of sinonasal HP on tissue eosinophilia and on CRS symptoms. There is a prognostic value for endonasal findings: CRS patients with HP have statistically significant greater improvement of the postoperative endoscopic scores.
authors.affiliation: Department of Otorhinolaryngology, Mostar University Hospital, Bijeli brijeg b.b, 88000 Mostar, Bosnia and Herzegovina. slav.boris@tel.net.ba
authors.forename: Boris
authors.initials: B
authors.lastname: Jelavic
authors.forename: Marko
authors.initials: M
authors.lastname: Grgić
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Cupić
authors.forename: Mirko
authors.initials: M
authors.lastname: Kordić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Vasilj
authors.forename: Tomislav
authors.initials: T
authors.lastname: Baudoin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000382:microbiology* / Q000601:surgery*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000382:microbiology*; D011379:Prognosis; D012220:Rhinitis / Q000382:microbiology* / Q000601:surgery*; D012852:Sinusitis / Q000382:microbiology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult