title: Novel speech signal processing algorithms for high-accuracy classification of Parkinson's disease.
abstract: There has been considerable recent research into the connection between Parkinson's disease (PD) and speech impairment. Recently, a wide range of speech signal processing algorithms (dysphonia measures) aiming to predict PD symptom severity using speech signals have been introduced. In this paper, we test how accurately these novel algorithms can be used to discriminate PD subjects from healthy controls. In total, we compute 132 dysphonia measures from sustained vowels. Then, we select four parsimonious subsets of these dysphonia measures using four feature selection algorithms, and map these feature subsets to a binary classification response using two statistical classifiers: random forests and support vector machines. We use an existing database consisting of 263 samples from 43 subjects, and demonstrate that these new dysphonia measures can outperform state-of-the-art results, reaching almost 99% overall classification accuracy using only ten dysphonia features. We find that some of the recently proposed dysphonia measures complement existing algorithms in maximizing the ability of the classifiers to discriminate healthy controls from PD subjects. We see these results as an important step toward noninvasive diagnostic decision support in PD.
authors.affiliation: Oxford Centre for Industrial and Applied Mathematics (OCIAM), Mathematical Institute, University of Oxford, Oxford, UK. tsanas@maths.ox.ac.uk
authors.forename: Athanasios
authors.initials: A
authors.lastname: Tsanas
authors.forename: Max A
authors.initials: MA
authors.lastname: Little
authors.forename: Patrick E
authors.initials: PE
authors.lastname: McSharry
authors.forename: Jennifer
authors.initials: J
authors.lastname: Spielman
authors.forename: Lorraine O
authors.initials: LO
authors.lastname: Ramig
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003663:Decision Trees; D055154:Dysphonia / Q000145:classification / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010300:Parkinson Disease / Q000145:classification* / Q000175:diagnosis / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D060388:Support Vector Machine