title: NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance.
abstract: The Nogo-66 receptor (NgR1) is part of a co-receptor complex on neurons that transmits a signal for inhibition of neurite outgrowth. In addition, NgR1 function has also been related to other disorders such as schizophrenia and Alzheimer's disease. Here, we studied the effect of life-long deletion of NgR1 (ngr(-/-)) in tests for cognition and positive symptoms of schizophrenia. In the water maze, ngr(-/-) mice learned to locate the hidden platform as well as wild type mice, although with slower acquisition. Deletion of NgR1 did not affect amphetamine- or phencyclidine (PCP)-induced hyperactivity, two models of positive symptoms of schizophrenia. Taken together, ngr(-/-) animals show slower acquisition of a spatial learning and memory task.
authors.affiliation: Neuroscience Research, GPRD, Abbott, 67061 Ludwigshafen, Germany. marcel.vangaalen@abbott.com
authors.forename: Marcel M
authors.initials: MM
authors.lastname: van Gaalen
authors.forename: Ana L
authors.initials: AL
authors.lastname: Relo
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Mueller
authors.forename: Gerhard
authors.initials: G
authors.lastname: Gross
authors.forename: Mario
authors.initials: M
authors.lastname: Mezler
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D004435:Eating; D005260:Female; D005334:Fever / Q000209:etiology; D006948:Hyperkinesis / Q000139:chemically induced; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009185:Myelin Proteins / Q000172:deficiency* / Q000235:genetics; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D010622:Phencyclidine / Q000494:pharmacology; D012149:Restraint, Physical; D012559:Schizophrenia / Q000139:chemically induced / Q000503:physiopathology; D013997:Time Factors
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603201:Rtn4 protein, mouse; D000661:Amphetamine; D010622:Phencyclidine