title: Trends in hip fracture incidence and in the prescription of antiosteoporosis medications during the same time period in Belgium (2000-2007).
abstract: OBJECTIVE
  To examine the secular trend of hip fracture incidence in Belgium between 2000 and 2007 and the concomitant change in the prescriptions of antiosteoporosis medications.
  
  
  METHODS
  The incidence of hip fractures and the number of prescriptions were determined using national databases. A logistic regression including years and 5-year age range was performed to assess the secular trend of hip fracture incidence, and Pearson's correlation coefficient was calculated to examine the relationship between hip fracture incidence and the prescriptions of antiosteoporosis medications.
  
  
  RESULTS
  The annual number of hip fractures increased in Belgium from 13,512 in 2000 to 14,744 in 2007, with a more marked increased in men (20.4%) than in women (5.7%). The age-adjusted incidence of hip fractures was significantly decreased by 1.12% per year in women, but declined nonsignificantly by 0.34% per year in men. An increase in the prescriptions of antiosteoporosis medications in women was observed during the same time period.
  
  
  CONCLUSIONS
  Despite an increase in the number of hip fractures in Belgium between 2000 and 2007, there was a significant decrease in age-adjusted incidence in women but not in men. Although our results suggest that the decrease may be related to the extent of antiosteoporosis medications, a causal relationship cannot be ascertained and many other factors may have contributed to the decrease in age-adjusted incidence.
authors.affiliation: Department of Public Health Sciences, University of Liège, Avenue de l'Hôpital 3, Liège, Belgium. m.hiligsmann@ulg.ac.be
authors.forename: Mickaël
authors.initials: M
authors.lastname: Hiligsmann
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
authors.forename: Dominique
authors.initials: D
authors.lastname: Roberfroid
authors.forename: Cécile
authors.initials: C
authors.lastname: Dubois
authors.forename: Yves
authors.initials: Y
authors.lastname: Parmentier
authors.forename: Joëlle
authors.initials: J
authors.lastname: Carton
authors.forename: Johann
authors.initials: J
authors.lastname: Detilleux
authors.forename: Pierre
authors.initials: P
authors.lastname: Gillet
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium / Q000453:epidemiology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016208:Databases, Factual / Q000639:trends; D011307:Drug Prescriptions; D005260:Female; D006620:Hip Fractures / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000453:epidemiology*; D013997:Time Factors
chemical_list: D050071:Bone Density Conservation Agents