title: Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses.
abstract: Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
authors.affiliation: WHO Collaborating Centre for Reference and Research on Infl uenza, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, 3051 Victoria,Australia. aeron.hurt@influenzacentre.org
authors.forename: Aeron C
authors.initials: AC
authors.lastname: Hurt
authors.forename: Sook Kwan
authors.initials: SK
authors.lastname: Leang
authors.forename: David J
authors.initials: DJ
authors.lastname: Speers
authors.forename: Ian G
authors.initials: IG
authors.lastname: Barr
authors.forename: Sebastian
authors.initials: S
authors.lastname: Maurer-Stroh
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D024882:Drug Resistance, Viral; D014943:Global Health; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008958:Models, Molecular; D053139:Oseltamivir / Q000494:pharmacology*; D058873:Pandemics; D011487:Protein Conformation
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir