title: Two new N-acetyldopamine tetrapolymers from periostracum Cicadae.
abstract: Two new N-acetyldopamine tetrapolymers, cicadamide A (1) and cicadamide B (2), were isolated from periostracum Cicadae, and their structures were elucidated as 3-acetylamino-7-(3″-acetylamino-7″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2'-(3″″,4″″-dihydroxyphenyl)-3'-acetylamino-1',4'-benzodioxan-7'-yl)-1,4-benzodioxane (1) and 3-acetylamino-7-(3″-acetylamino-6″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2'-(3″″,4″″-dihydroxyphenyl)-3'-acetylamino-1',4'-benzodioxan-7'-yl)-1,4-benzodioxane (2), by the combined analysis of 1D NMR and 2D NMR, and mass spectrometry. Pharmacological investigation on two compounds obtained in this study showed that part of them had anti-inflammatory activities.
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi, 832002, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Guo-Yu
authors.initials: GY
authors.lastname: Li
authors.forename: Qi-Rui
authors.initials: QR
authors.lastname: Li
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006430:Hemiptera / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C571018:cicadamide A; C571019:cicadamide B; C006374:N-acetyldopamine; D004298:Dopamine