title: Peroxydisulfate activation by [RuII(tpy)(pic)(H2O)]+. Kinetic, mechanistic and anti-microbial activity studies.
abstract: The oxidation of [Ru(II)(tpy)(pic)H(2)O](+) (tpy = 2,2',6',2''-terpyridine; pic(-) = picolinate) by peroxidisulfate (S(2)O(8)(2-)) as precursor oxidant has been investigated kinetically by UV-VIS, IR and EPR spectroscopy. The overall oxidation of Ru(II)- to Ru(IV)-species takes place in a consecutive manner involving oxidation of [Ru(II)(tpy)(pic)H(2)O](+) to [Ru(III)(tpy)(pic)(OH)](+), and its further oxidation of to the ultimate product [Ru(IV)(tpy)(pic)(O)](+) complex. The time course of the reaction was followed as a function of [S(2)O(8)(2-)], ionic strength (I) and temperature. Kinetic data and activation parameters are interpreted in terms of an outer-sphere electron transfer mechanism. Anti-microbial activity of Ru(II)(tpy)(pic)H(2)O](+) complex by inhibiting the growth of Escherichia coli DH5α in presence of peroxydisulfate has been explored, and the results of the biological studies have been discussed in terms of the [Ru(IV)(tpy)(pic)(O)](+) mediated cleavage of chromosomal DNA of the bacteria.
authors.affiliation: Central Mechanical Engineering Research Institute, Durgapur, India. dchat57@hotmail.com
authors.forename: Debabrata
authors.initials: D
authors.lastname: Chatterjee
authors.forename: Priyabrata
authors.initials: P
authors.lastname: Banerjee
authors.forename: Jagadeesh C K
authors.initials: JC
authors.lastname: Bose
authors.forename: Sudit
authors.initials: S
authors.lastname: Mukhopadhyay
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D058491:Bacterial Load; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007700:Kinetics; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology; D013431:Sulfates / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D010545:Peroxides; D010848:Picolinic Acids; D011725:Pyridines; D013431:Sulfates; D012428:Ruthenium