title: CVID enteropathy- a rare cause of chronic diarrhea in a child.
abstract: Common variable immunodeficiency (CVID) is a rare primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections especially in respiratory and gastrointestinal systems. The authors present here a case of CVID with uncommon gastrointestinal manifestation in the form of CVID enteropathy. Based upon the clinical presentation and histopatholic findings the patient was diagnosed as CVID enteropathy and treated with intravenous antibiotics and 3-4 wkly intravenous immunoglobulin infusion and he had responded poorly to gastrointestinal symptoms but the frequency of respiratory and skin infection reduced. CVID has heterogenous gastrointestinal manifestations; among them the CVID enteropathy is an uncommon presentation which responds poorly to the mainstay therapy of intravenous immunoglobulin infusion and represents a diagnostic as well as therapeutic challenge for treating physician.
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai, Maharashtra 400022, India. drjigs2712@gmail.com
authors.forename: Jignesh
authors.initials: J
authors.lastname: Patel
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.forename: Anantakumar
authors.initials: A
authors.lastname: Agasti
authors.forename: Ajay
authors.initials: A
authors.lastname: Choksey
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Phadke
authors.forename: Prabha
authors.initials: P
authors.lastname: Sawant
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D008297:Male
chemical_list: D007136:Immunoglobulins