title: Surgical management of the succinate dehydrogenase-associated familial paraganglioma syndromes.
abstract: Paragangliomas are rare neuroendocrine tumors arising from the neural crest cells in the extra-adrenal location. Paragangliomas can be sporadic or associated with a range of endocrine and genetic syndromes in 25% to 30% of all cases. Specifically, succinate dehydrogenase gene mutations are involved in the development of paraganglioma syndromes type 1 through type 4. In this article, we will describe 2 cases of succinate dehydrogenase-associated familial paraganglioma syndrome and provide a review of the existing literature on the condition's etiologic factors, diagnosis, and management.
authors.affiliation: Department of Surgery, Danbury Hospital, 24 Hospital Ave, Danbury, CT 06810, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Cocieru
authors.forename: Pierre F
authors.initials: PF
authors.lastname: Saldinger
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis / Q000201:enzymology* / Q000601:surgery* / Q000628:therapy; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D013577:Syndrome
chemical_list: D013385:Succinate Dehydrogenase