title: National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on late effects after pediatric hematopoietic cell transplantation: the need for pediatric-specific long-term follow-up guidelines.
abstract: Existing standards for screening and management of late effects occurring in children who have undergone hematopoietic cell transplantation (HCT) include recommendations from pediatric cancer networks and consensus guidelines from adult-oriented transplantation societies applicable to all HCT recipients. Although these approaches have significant merit, they are not pediatric HCT-focused, and they do not address post-HCT challenges faced by children with complex nonmalignant disorders. In this article we discuss the strengths and weaknesses of current published recommendations and conclude that pediatric-specific guidelines for post-HCT screening and management would be beneficial to the long-term health of these patients and would promote late effects research in this field. Our panel of late effects experts also provides recommendations for follow-up and therapy of selected post-HCT organ and endocrine complications in pediatric patients.
authors.affiliation: Primary Children's Medical Center, University of Utah School of Medicine/Huntsman Cancer Institute, Division of Hematology/BMT, Salt Lake City, Utah 84132, USA. michael.pulsipher@hsc.utah.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
authors.forename: Roderick
authors.initials: R
authors.lastname: Skinner
authors.forename: George B
authors.initials: GB
authors.lastname: McDonald
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Hingorani
authors.forename: Saro H
authors.initials: SH
authors.lastname: Armenian
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Cooke
authors.forename: Clarisa
authors.initials: C
authors.lastname: Gracia
authors.forename: Anna
authors.initials: A
authors.lastname: Petryk
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
authors.forename: Nancy
authors.initials: N
authors.lastname: Bunin
authors.forename: Michael L
authors.initials: ML
authors.lastname: Nieder
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Dvorak
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.forename: Jean E
authors.initials: JE
authors.lastname: Sanders
authors.forename: Joanne
authors.initials: J
authors.lastname: Kurtzberg
authors.forename: K Scott
authors.initials: KS
authors.lastname: Baker
mesh_terms: D002648:Child; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000592:standards*; D006801:Humans; D054547:National Cancer Institute (U.S.); D010372:Pediatrics / Q000379:methods* / Q000592:standards*; D017410:Practice Guidelines as Topic; D014481:United States