title: Measurement of the traction force of biological cells by digital holography.
abstract: The traction force produced by biological cells has been visualized as distortions in flexible substrata. We have utilized quantitative phase microscopy by digital holography (DH-QPM) to study the wrinkling of a silicone rubber film by motile fibroblasts. Surface deformation and the cellular traction force have been measured from phase profiles in a direct and straightforward manner. DH-QPM is shown to provide highly efficient and versatile means for quantitatively analyzing cellular motility.
authors.affiliation: Digital Holography and Microscopy Laboratory, Department of Physics, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.forename: Michael
authors.initials: M
authors.lastname: Cross
authors.forename: Changgeng
authors.initials: C
authors.lastname: Liu
authors.forename: David C
authors.initials: DC
authors.lastname: Clark
authors.forename: Donald T
authors.initials: DT
authors.lastname: Haynie
authors.forename: Myung K
authors.initials: MK
authors.lastname: Kim