title: Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: the direct synthesis of 3-hydroxyisoindolin-1-ones.
abstract: The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp(2) C-H bond activation followed by an intramolecular cyclization is described. This method results in the direct and efficient synthesis of 3-hydroxyisoindolin-1-one building blocks.
authors.affiliation: Department of Chemistry, University of Ulsan, Ulsan, 680-749, Republic of Korea.
authors.forename: Satyasheel
authors.initials: S
authors.lastname: Sharma
authors.forename: Eonjeong
authors.initials: E
authors.lastname: Park
authors.forename: Jihye
authors.initials: J
authors.lastname: Park
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006900:Hydroxylation; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001549:Benzamides; D007211:Indoles; C057812:indoline; D012238:Rhodium