title: [Application of liquid chromatography-high resolution mass spectrometry in toxicological screening].
abstract: Due to the diversity of toxicologically relevant substances, the uncertainty of target compounds and the specificity of samples, toxicological screening techniques have always been valued by the forensic toxicologists. Depending on its powerful separation ability, superhigh resolution and accurate mass measurement, combined with the two levels spectrum database matching and abundance ratio of isotope ion, the liquid chromatography-high resolution mass spectrometry (LC-HRMS) analyzers have increasingly advantage in screening and identification of chemical compound. This review focuses on the applications of LC-HRMS in screening and identification of drug-of-abuse, prescription drugs, pesticide and stimulant. The prospect of LC-HRMS in forensic toxicology analysis is also included.
authors.affiliation: Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China. 09211010055@fudan.edu.cn
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Li
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Shen
authors.forename: Xian-Yi
authors.initials: XY
authors.lastname: Zhuo
mesh_terms: D002491:Central Nervous System Agents / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods*; D004300:Doping in Sports; D053593:Forensic Toxicology / Q000379:methods*; D006801:Humans; D010573:Pesticide Residues / Q000032:analysis; D010575:Pesticides / Q000032:analysis*; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D002491:Central Nervous System Agents; D010573:Pesticide Residues; D010575:Pesticides