title: [Inner ear cell therapy for hereditary deafness with multipotent stem cells].
abstract: Congenital deafness affects about 1 in 1000 children and the half of them have genetic background such as connexin26 gene mutation. The strategy to rescue such hereditary deafness has not been developed yet. Inner ear cell therapy for hereditary deafness has been studied using some laboratory animals and multipotent stem cells, although the successful reports for the hearing recovery accompanied with supplementation of the normal functional cells followed by tissue repair and recovery of the cellular/molecular functions have been still few. To succeed in hearing recovery by inner ear cell therapy, appropriate cell type, surgical approach and the stem cell homing system to the niche are thought to be required.
authors.affiliation: Department of Otorhinolaryngology, Juntendo University School of Medicine.
authors.forename: Kazusaku
authors.initials: K
authors.lastname: Kamiya
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D003638:Deafness / Q000151:congenital* / Q000628:therapy*; D051379:Mice; D039902:Multipotent Stem Cells / Q000637:transplantation*; D051381:Rats