title: Autoimmune hemolytic anemia and immune thrombocytopenia as unusual presentations of childhood Hodgkin lymphoma: a case report and review of the literature.
abstract: We discuss an unusual clinical presentation of childhood Hodgkin lymphoma; a 16-year-old girl was referred for Coombs-positive severe anemia, thrombocytopenia, and asymptomatic anterior mediastinal mass. Bone marrow examination showed no evidence of neoplastic disease. Biopsy of the mass was possible only after administration of both intravenous immunoglobulins and steroids resulting in a prompt rise of the platelet count and partial hemoglobin level stabilization. The identification of this clinical picture as a possible complication of an underlying Hodgkin lymphoma presents difficulties in diagnosis and management of the primary condition.
authors.affiliation: Department of Cellular Biotechnologies and Hematology, Division of Hematology, Rome, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Cecinati
authors.forename: Fulvia
authors.initials: F
authors.lastname: Brugnoletti
authors.forename: Mariella
authors.initials: M
authors.lastname: D'Angiò
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: De Nicolò
authors.forename: Annalisa
authors.initials: A
authors.lastname: De Vellis
authors.forename: Serelina
authors.initials: S
authors.lastname: Coluzzi
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Testi
mesh_terms: D000293:Adolescent; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D013256:Steroids
chemical_list: D016756:Immunoglobulins, Intravenous; D013256:Steroids