title: Cell-based therapy to promote angiogenesis in the brain following ischemic damage.
abstract: Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
authors.affiliation: Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Uemura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nagatsuka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D055806:Microvessels / Q000378:metabolism; D018919:Neovascularization, Physiologic; D055495:Neurogenesis; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000503:physiopathology / Q000628:therapy*
chemical_list: D018952:Antigens, CD34