title: Well differentiated thyroid carcinoma: current treatment.
abstract: Well differentiated thyroid carcinoma (WDTC) is a relatively common malignancy accounting for an estimated 37,000 thousand cases in the United States in 2009 [1]. WDTC also has a generally high 5 year survival rate that correlates with age. Papillary thyroid carcinoma (PTC) greater than 1 cm is best managed by total thyroidectomy. Thyroid lobectomy and isthmusectomy may be adequate for unifocal PTC less than 1 cm in patients without negative prognostic factors. Central compartment and possible lateral neck dissections should be performed when nodal metastases are present in the respective nodal basins. Post-operatively, radioactive iodine ablation with (131)I followed by thyroid stimulating hormone (TSH) suppression is indicated in certain patients to improve locoregional control and reduce recurrence.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425-5500, USA. byrdj@musc.edu
authors.forename: J Kenneth
authors.initials: JK
authors.lastname: Byrd
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Yawn
authors.forename: Christina S T
authors.initials: CS
authors.lastname: Wilhoit
authors.forename: Nicoleta D
authors.initials: ND
authors.lastname: Sora
authors.forename: Linda
authors.initials: L
authors.lastname: Meyers
authors.forename: Jyotika
authors.initials: J
authors.lastname: Fernandes
authors.forename: Terry
authors.initials: T
authors.lastname: Day
mesh_terms: D002277:Carcinoma; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008297:Male; D037981:Neck Dissection / Q000379:methods; D011379:Prognosis; D015996:Survival Rate; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D013965:Thyroidectomy / Q000379:methods; D013974:Thyroxine / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology
chemical_list: D007457:Iodine Radioisotopes; D013974:Thyroxine