title: Peptidergic regulation of thymocyte differentiation, proliferation, and apoptosis during aging of the thymus.
abstract: The effects of T-31, AB-17, and AB-9 peptides on old (passage 8) thymocyte culture were studied. Only AB-9 peptide exhibited a complex geroprotective effect on thymocytes during their aging. Peptide AB-9 stimulated proliferative activity and differentiation of thymocytes and inhibited their apoptosis.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, North Western Division of Russian Academy of Medical Sciences, Russia. miayy@yandex.ru
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: A V
authors.initials: AV
authors.lastname: Trofimov
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging; D015703:Antigens, CD / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology*; D005333:Fetus; D006801:Humans; D007223:Infant; D009842:Oligopeptides / Q000494:pharmacology*; D060168:Thymocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology
chemical_list: D015703:Antigens, CD; D004151:Dipeptides; C572339:Nalpha-(gamma-glutamyl)lysine; D009842:Oligopeptides; C572340:alanyl-glutamyl-aspartic acid; C415909:lysylglutamic acid