title: An improved real-time cine Late Gadolinium Enhancement (LGE) imaging method at 3T.
abstract: A real-time Late Gadolinium Enhancement (LGE) MRI technique (free breathing and non-gated) is presented for detection of myocardial scars. Conventional LGE imaging methods currently in use are applied in conjunction with breath-hold and, thus, are difficult to use in patients with cardiac disease and may lead to motion artifacts. Additionally, conventional techniques involve ECG gating, which is problematic in patients with arrhythmias requiring multiple breath holds and use of arrhythmia rejection techniques. Finally, conventional LGE techniques require accurate estimates for the inversion time in order to null the normal myocardium, revealing the location of the scar with high contrast. Real-time LGE imaging obviates these difficulties and can, in principle, acquire cine images to assess wall motion over several heart phases as part of the same scan. To date, the main limitation of real-time LGE imaging has been long acquisition window and low temporal resolution. These limitations lead to temporal blurring of wall motion and possible overestimation of infarct size. The goal of this study was to increase the temporal resolution of real-time, cine LGE imaging, providing the possibility for better visualization of the wall motion and more accurate assessment of myocardial viability.
authors.affiliation: Medical Imaging Lab, Electrical and Computer Engineering Department, University of Louisville, Louisville, KY, United States. m0kadb01@louisville.edu
authors.forename: Mo
authors.initials: M
authors.lastname: Kadbi
authors.forename: Melanie
authors.initials: M
authors.lastname: Kotys
authors.forename: Motaz
authors.initials: M
authors.lastname: Alshaher
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
authors.forename: Amir A
authors.initials: AA
authors.lastname: Amini
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D017682:Myocardial Stunning / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA