title: [Regenerative medicine in cornea].
abstract: Cornea is unique organ in its transparency. It consists of three different layers epithelium, stroma, and endothelium. Defect of each layers decrease the transparency resulting in blindness. Corneal transplant from donors is performed for these conditions. However it sometimes does not work because of immuno-rejection and shortage of donors is still problem. Regenerative medicine resolves these problems. According to epithelium, we had succeeded in making epithelial sheet from oral mucosa epithelium. The sheet is clear and very resembles normal corneal epithelium in histology. We have auto transplantation of this epithelial sheet to severe corneal deficiency patients and obtained good clinical results. According to endothelium, we are trying to make the sheet from various stem sells including iPS cells.
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine.
authors.forename: Motokazu
authors.initials: M
authors.lastname: Tsujikawa
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
mesh_terms: D003315:Cornea / Q000601:surgery*; D004848:Epithelium / Q000637:transplantation; D006801:Humans; D009061:Mouth Mucosa / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods