title: Flow injection photometric determination of NaCl, KCl and glucose in injectable drugs exploiting Schlieren signals.
abstract: A flow injection photometric system that exploits Schlieren signals for analytical measurement is described. The system was designed to be used as a new strategy for determining the contents of sodium chloride, potassium chloride and glucose, each respectively in injectable drugs. The proposed methodology was based on the difference between the refractive indices of the sample zone and of the carrier stream. With this perspective, a lab-made photometer based on LED-phototransistor technology was employed as a detection system to investigate the different analytical profiles related to the Schlieren effect in low flow rate conditions. The parameters of the flow system, such as flow-rate, optical path length, and sampling loop, were adjusted in order to obtain suitable Schlieren profiles for the measurements. Data evaluation was performed with the application of partial least squares regression (PLS-1). The obtained results demonstrated the predictive ability of the constructed PLS models, and the predicted concentration values were in agreement with the reference values, with a 95% confidence level.
authors.affiliation: Departamento de Química, CCEN, Universidade Federal da Paraíba, PO Box 5093, CEP 58051-970, João Pessoa, PB, Brazil.
authors.forename: Paulo Henrique Gonçalves Dias
authors.initials: PH
authors.lastname: Diniz
authors.forename: Karla Danielle Tavares
authors.initials: KD
authors.lastname: de Melo
authors.forename: Yebá Ngoamãn Martins
authors.initials: YN
authors.lastname: Fagundes
authors.forename: Adriano
authors.initials: A
authors.lastname: de Araujo Gomes
authors.forename: Elaine Cristina Lima
authors.initials: EC
authors.lastname: do Nascimento
authors.forename: Sérgio Ricardo Bezerra
authors.initials: SR
authors.lastname: dos Santos
authors.forename: Luciano Farias
authors.initials: LF
authors.lastname: de Almeida
authors.forename: Mário César Ugulino
authors.initials: MC
authors.lastname: de Araújo
mesh_terms: D017022:Flow Injection Analysis / Q000379:methods*; D005947:Glucose / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011189:Potassium Chloride / Q000032:analysis*; D012965:Sodium Chloride / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D012965:Sodium Chloride; D011189:Potassium Chloride; D005947:Glucose