title: Adiponectin and leptin systems in human endometrium during window of implantation.
abstract: OBJECTIVE
  To measure the expression of adiponectin, leptin, and their respective receptors in the human endometria of fertile women compared with women with unexplained recurrent implantation failure (IF) during the window of implantation.
  
  
  METHODS
  Controlled, prospective, clinical study.
  
  
  METHODS
  Teaching hospital and university research laboratory.
  
  
  METHODS
  Thirty-one endometrial biopsies from women with IF and 19 fertile controls.
  
  
  METHODS
  Human endometrial biopsies.
  
  
  METHODS
  Gene and protein expression of endometrial biopsies.
  
  
  RESULTS
  Endometrial leptin expression was significantly lower in the IF group compared with fertile women. In contrast, leptin receptor (Ob-R) expression was higher in endometria of women with IF. Concerning the adiponectin system, adiponectin was expressed to the same extent in both groups. Conversely, the expression of its two receptors, AdipoR1 and AdipoR2, was reduced in endometria of women with IF compared with fertile women.
  
  
  CONCLUSIONS
  Although progesterone resistance seems to be a common state of the endometrium in some human reproductive disorders, such as endometriosis or polycystic ovary syndrome, modification in leptin endometrial expression seems to be specific to IF. These results strongly suggest that changes in Ob-R and AdipoR expression profiles [1] should be implicated in the development of uterine receptivity, and [2] may therefore be potential new targets for prediction of IF.
authors.affiliation: Service de Biochimie et Biologie Moléculaire, Unité Propre de Recherche et de l'Enseignement Supérieur- Equipe d'Accueil 2493, Pôle de Recherche et de l'Enseignement Supérieur Universud Paris, Centre Hospitalier de Poissy-Saint Germain, Poissy Cedex, France. dossantos.esther@orange.fr
authors.forename: Esther
authors.initials: E
authors.lastname: Dos Santos
authors.forename: Valérie
authors.initials: V
authors.lastname: Serazin
authors.forename: Corinne
authors.initials: C
authors.lastname: Morvan
authors.forename: Antoine
authors.initials: A
authors.lastname: Torre
authors.forename: Robert
authors.initials: R
authors.lastname: Wainer
authors.forename: Philippe
authors.initials: P
authors.lastname: de Mazancourt
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Dieudonné
mesh_terms: D052242:Adiponectin / Q000032:analysis* / Q000235:genetics; D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D005307:Fertilization in Vitro; D005786:Gene Expression Regulation; D006784:Hospitals, Teaching; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D020738:Leptin / Q000032:analysis* / Q000235:genetics; D010297:Paris; D011247:Pregnancy; D011446:Prospective Studies; D012333:RNA, Messenger / Q000032:analysis; D054419:Receptors, Adiponectin / Q000032:analysis* / Q000235:genetics; D054411:Receptors, Leptin / Q000032:analysis* / Q000235:genetics; D017211:Treatment Failure
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; C515448:LEPR protein, human; D020738:Leptin; D012333:RNA, Messenger; D054419:Receptors, Adiponectin; D054411:Receptors, Leptin