title: Production of late IFN-α induced by plasma γ-globulin fraction proteins and their metal complexes.
abstract: Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes they form with human serum γ-globulin induce the production of IFN-α by human blood cells throughout the periods of up to 72 h. Zinc cation-modified protein by 1.6 times (p<0.05) more actively induces late IFN-α than the control γ-globulin; γ-globulin-copper metal complex is 2-fold (p<0.002) more effective than the control protein. The results indicate that functional relationships between the components inducing the production of late IFN-α differ from the effects realized during the early period of induction.
authors.affiliation: Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. cheknev@gamaleya.org
authors.forename: S B
authors.initials: SB
authors.lastname: Cheknev
authors.forename: A A
authors.initials: AA
authors.lastname: Babajanz
authors.forename: I E
authors.initials: IE
authors.lastname: Efremova
authors.forename: L S
authors.initials: LS
authors.lastname: Piskovskaya
mesh_terms: D002478:Cells, Cultured; D056831:Coordination Complexes / Q000494:pharmacology*; D003300:Copper / Q000097:blood / Q000378:metabolism; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis*; D015032:Zinc / Q000097:blood / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D056831:Coordination Complexes; D016898:Interferon-alpha; D005719:gamma-Globulins; D003300:Copper; D015032:Zinc