title: The HIV-1 Rev response element: an RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex.
abstract: The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Fernandes
authors.forename: Bhargavi
authors.initials: B
authors.lastname: Jayaraman
authors.forename: Alan
authors.initials: A
authors.lastname: Frankel
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D030541:Databases, Genetic; D015967:Gene Expression Regulation, Viral; D015757:Genes, rev; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020218:Response Elements; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D019065:Virus Assembly
chemical_list: D046912:Multiprotein Complexes; D012333:RNA, Messenger; D012261:Ribonucleoproteins