title: Magnetic resonance imaging for pancreatic ductal adenocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters.
abstract: OBJECTIVE
  This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters.
  
  
  METHODS
  A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated group (n = 80; with weekly subcutaneous injections of BOP [10 mg/kg body weight] for 7 consecutive weeks), a saline-treated group (n = 16), and an untreated group (n = 5). Hamsters underwent abdominal MRI on 1.5-T MR scanners with a dedicated animal radiofrequency coil. Findings of the tumor from the MRI were compared those from histology.
  
  
  RESULTS
  Pancreata in the saline-treated and in the untreated groups were normal. In the BOP-treated group, there were 23 and 31 BOP-induced PDAs on macroscopy and microscopy, respectively. Of the PDAs detected on macroscopy, 65.2% were depicted on MRI. As early as 13 and 19 weeks after the first injection of BOP, PDAs in hamsters were found on histology and MRI, respectively. Moreover, the tumor volume on MRI was correlated with the tumor weights excised (r = 0.96, P = 0.000, n = 15).
  
  
  CONCLUSIONS
  N-nitrosobis (2-oxopropyl) amine successfully induced PDAs in hamsters. Magnetic resonance imaging has the ability to detect healthy pancreas and PDAs in hamsters and has the potential to monitor the development of PDAs.
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, Department of Radiology, North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Qing Song
authors.initials: QS
authors.lastname: Ma
authors.forename: Xiao Ming
authors.initials: XM
authors.lastname: Zhang
authors.forename: Cheng Yi
authors.initials: CY
authors.lastname: Shen
authors.forename: Nan Lin
authors.initials: NL
authors.lastname: Zeng
authors.forename: Ze Shan
authors.initials: ZS
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Pu
authors.forename: Chao Ying
authors.initials: CY
authors.lastname: Wu
authors.forename: Li Sui
authors.initials: LS
authors.lastname: Zhou
authors.forename: Zheng Wei
authors.initials: ZW
authors.lastname: Yang
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000005:Abdomen / Q000528:radiation effects; D000818:Animals; D002273:Carcinogens; D021441:Carcinoma, Pancreatic Ductal / Q000139:chemically induced / Q000175:diagnosis*; D006224:Cricetinae; D005260:Female; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008647:Mesocricetus; D009602:Nitrosamines; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000175:diagnosis; D011859:Radiography; D011897:Random Allocation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D047368:Tumor Burden
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine