title: [Progress in the study of allergic disease drugs targeting on IgE/FcepsilonRI signaling pathway].
abstract: Allergic diseases have become global social health problems. The binding of IgE with its high affinity receptor FcepsilonRI plays a key step in I-type allergy. Recently, more and more key molecules on the IgE/FcepsilonRI signaling transduction pathway were to be the drug candidates against allergic diseases, with in-depth study of FcepsilonRI signal pathway gradually. The main drugs include molecule antibodies, peptides, vaccines, fusion proteins, small molecules, and other drugs related to IgE/FcepsilonRI. The recent progress in the study of mechanisms of representative drugs targeting on IgE/FcepsilonRI signaling pathway was reviewed in this article.
authors.affiliation: Key Laboratory for Drug Quality Control and Analysis of Hebei Province, Baoding 071002, China. liuzc@hbu.edu.cn
authors.forename: Zhong-cheng
authors.initials: ZC
authors.lastname: Liu
authors.forename: Hai-lang
authors.initials: HL
authors.lastname: Shi
authors.forename: Yan-fen
authors.initials: YF
authors.lastname: Zhang
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhao
mesh_terms: D000627:Aminophenols / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D007073:Immunoglobulin E / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors; D058990:Molecular Targeted Therapy; D000069444:Omalizumab; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D017455:Receptors, IgE / Q000378:metabolism*; D015398:Signal Transduction; D000072377:Syk Kinase
chemical_list: C514111:2,4-bis(3-hydroxyphenylamino)-5-fluoropyrimidine; D000627:Aminophenols; D018926:Anti-Allergic Agents; D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; D047908:Intracellular Signaling Peptides and Proteins; D011743:Pyrimidines; D017455:Receptors, IgE; D000069444:Omalizumab; D007073:Immunoglobulin E; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase