title: Diclavatol and tetronic acids from Penicillium griseoroseum.
abstract: In our continuous studies on the chemistry of the endophytic fungus Penicillium griseoroseum, an endophyte isolated from fruits of Coffea arabica, we isolated clavatol, a dimethylated tetraketide, and its dimer which appears to be a novel natural compound. The studies also resulted in the identification of two known tetronic acids, viridicatic acid and terrestric acid, found in ethyl acetate and n-butanol extracts. Spectroscopic studies using 1-D and 2-D NMR and MS/MS analysis were performed to determine the structures of these compounds, first reported by this Penicillium. Two other tetronic acids congeners were identified through HPLC/MS/MS studies, based on fragmentation pattern of ions produced from ionised tetronic acids, and UV light absorptions.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, CEP 13.565-905, CP 676, São Carlos, SP, Brazil.
authors.forename: José Vinicius
authors.initials: JV
authors.lastname: da Silva
authors.forename: Taicia Pacheco
authors.initials: TP
authors.lastname: Fill
authors.forename: Bianca Ferreira
authors.initials: BF
authors.lastname: da Silva
authors.forename: Edson
authors.initials: E
authors.lastname: Rodrigues-Fo
mesh_terms: D005663:Furans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D005663:Furans; C003422:tetronic acid