title: Penetrating keratoplasty in congenital hereditary endothelial dystrophy.
abstract: OBJECTIVE
  To compare the results of penetrating keratoplasty (PK) in a series of congenital hereditary endothelial dystrophy (CHED) patients operated at amblyogenic years and at later ages.
  
  
  METHODS
  Records of 65 eyes of 35 CHED patients who underwent PK were reviewed retrospectively. Visual results and graft clarity rates were compared between patients operated after (group 1) and before (group 2) 12 years of age. Results were also compared between eyes with and without nystagmus.
  
  
  RESULTS
  Group 1 consisted of 47 eyes (24 patients), whereas group 2 consisted of 18 eyes (11 patients). Thirteen patients (54%) in group 1 and 10 patients (91%) in group 2 had nystagmus. Mean ages at surgery were 26.4 and 7.6 years in group 1 and group 2, respectively. Mean follow-up period was 101.0 months in group 1 and 59.7 months in group 2. Group 1 cases had better graft clarity rates than group 2 cases (P = 0.023). Postoperative best-corrected visual acuities (BCVAs) were 20/80 or better in 39 eyes of group 1 (83%) and in 5 eyes of group 2 (28%). Visual outcomes were found significantly better in group 1 cases (P < 0.001). In group 1, 76% of eyes with nystagmus and 91% of eyes without nystagmus had BCVAs of 20/80 or better. In group 1, both preoperative and postoperative BCVAs were found significantly better in eyes without nystagmus (P < 0.001 and P = 0.002, respectively).
  
  
  CONCLUSIONS
  Delayed keratoplasty seems to offer better graft outcomes and visual prognosis to CHED patients, even in the presence of nystagmus.
authors.affiliation: Kartal Training and Education Hospital, Second Eye Clinic, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Özdemir
authors.forename: Anil
authors.initials: A
authors.lastname: Kubaloğlu
authors.forename: Arif
authors.initials: A
authors.lastname: Koytak
authors.forename: Erol
authors.initials: E
authors.lastname: Coskun
authors.forename: Yasin
authors.initials: Y
authors.lastname: Çinar
authors.forename: Esin Sogutlu
authors.initials: ES
authors.lastname: Sari
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Özertürk
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000502:physiology; D003317:Corneal Dystrophies, Hereditary; D005099:Exotropia / Q000150:complications; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000503:physiopathology / Q000601:surgery*; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D009759:Nystagmus, Pathologic / Q000150:complications; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult