title: [Classification of substances to predict the order of magnitude of their safe water levels in terms of carcinogenic effect].
abstract: A classification has been developed to predict the safe water levels of chemical compounds in terms of their carcinogenic effect, by using as the base the LTD@10 value that is a lower 95% confidence limits for the lowest dose that statistically significantly causes a 10% increase in the incidence of cancer in laboratory animals continuously receiving a daily dose of the compound throughout their life, which is given in the CPDB internet resource, and the carcinogenicity classification adopted by the International Agency or Research on Cancer Based on an analysis ofthe maximum allowable concentration (MAC) of the standardized water substances in terms of their carcinogenic effect, the authors determined MA4 C ranges corresponding to different classes in accordance with the proposed classification. They predicted the orders of magnitude of MAC of the standardized water substances without taking into account their carcinogenic effect and those of four substances unstandardized in Russia.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Zholdakova
authors.forename: N V
authors.initials: NV
authors.lastname: Kharchevnikova
mesh_terms: D000465:Algorithms; D000818:Animals; D002274:Carcinogens, Environmental / Q000032:analysis / Q000145:classification* / Q000633:toxicity; D003198:Computer Simulation; D006801:Humans; D008452:Maximum Allowable Concentration; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012426:Russia; D012449:Safety; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000145:classification* / Q000633:toxicity; D014881:Water Supply / Q000592:standards
chemical_list: D002274:Carcinogens, Environmental; D014874:Water Pollutants, Chemical