title: Chemical-genomic profiling: systematic analysis of the cellular targets of bioactive molecules.
abstract: Chemical-genomic (CG) profiling of bioactive compounds is a powerful approach for drug target identification and mode of action studies. Within the last decade, research focused largely on the development and application of CG approaches in the model yeast Saccharomyces cerevisiae. The success of these methods has sparked interest in transitioning CG profiling to other biological systems to extend clinical and evolutionary relevance. Additionally, CG profiling has proven to enhance drug-synergy screens for developing combinatorial therapies. Herein, we briefly review CG profiling, focusing on emerging cross-species technologies and novel drug-synergy applications, as well as outlining needs within the field.
authors.affiliation: Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College St., Toronto, ON, Canada M5S 3E1.
authors.forename: Kerry
authors.initials: K
authors.lastname: Andrusiak
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Piotrowski
authors.forename: Charles
authors.initials: C
authors.lastname: Boone
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods*; D004357:Drug Synergism; D020869:Gene Expression Profiling / Q000379:methods; D053263:Gene Regulatory Networks / Q000187:drug effects; D023281:Genomics / Q000379:methods*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics
chemical_list: D000935:Antifungal Agents