title: Diverse trifluoromethyl heterocycles from a single precursor.
abstract: Ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate is a highly versatile intermediate for the synthesis of a wide range of trifluoromethyl heterocycles. With the use of rhodium(II) or copper(II) catalyzed carbene X-H insertion reactions as key steps, a diverse set of trifluoromethyl-oxazoles, -thiazoles, -imidazoles, -1,2,4-triazines, and -pyridines are available from the diazoketoester, either directly in a single step or with just one additional step.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Honey
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pasceri
authors.forename: William
authors.initials: W
authors.lastname: Lewis
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Moody
mesh_terms: D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry
chemical_list: D005617:Chlorofluorocarbons, Methane; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; C009554:fluoroform