title: RIBER/DIBER: a software suite for crystal content analysis in the studies of protein-nucleic acid complexes.
abstract: Co-crystallization experiments of proteins with nucleic acids do not guarantee that both components are present in the crystal. We have previously developed DIBER to predict crystal content when protein and DNA are present in the crystallization mix. Here, we present RIBER, which should be used when protein and RNA are in the crystallization drop. The combined RIBER/DIBER suite builds on machine learning techniques to make reliable, quantitative predictions of crystal content for non-expert users and high-throughput crystallography.
authors.affiliation: International Institute of Molecular and Cell Biology, Warsaw, Poland. gchojnowski@genesilico.pl
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Chojnowski
authors.forename: Janusz M
authors.initials: JM
authors.lastname: Bujnicki
authors.forename: Matthias
authors.initials: M
authors.lastname: Bochtler
mesh_terms: D001185:Artificial Intelligence; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D030562:Databases, Protein; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D012984:Software
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA