title: Pathogenesis of AF: impact on intracardiac signals.
abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for the highest number of rhythm-related disorders and cardioembolic strokes worldwide. Intracardiac signal analysis during the onset of paroxysmal AF led to the discovery of pulmonary vein as a triggering source of AF, which has led to the development of pulmonary vein ablation--an established curative therapy for drug-resistant AF. Complex, multicomponent and rapid electrical activity widely involving the atrial substrate characterizes persistent/permanent AF. Widespread nature of the problem and complexity of signals in persistent AF reduce the success rate of ablation therapy. Although signal processing applied to extraction of relevant features from these complex electrograms has helped to improve the efficacy of ablation therapy in persistent/permanent AF, improved understanding of complex signals should help to identify sources of AF and further increase the success rate of ablation therapy.
authors.affiliation: Hopital Cardiologique du Haut-Lévèque, Université Victor Segalen, Bordeaux II, France. drashahep@gmail.com
authors.forename: Ashok J
authors.initials: AJ
authors.lastname: Shah
authors.forename: Rémi
authors.initials: R
authors.lastname: Dubois
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Amir S
authors.initials: AS
authors.lastname: Jadidi
authors.forename: Daniel
authors.initials: D
authors.lastname: Scherr
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Wilton
authors.forename: Laurent
authors.initials: L
authors.lastname: Roten
authors.forename: Patrizio
authors.initials: P
authors.lastname: Pascale
authors.forename: Michala
authors.initials: M
authors.lastname: Pedersen
authors.forename: Nicolas
authors.initials: N
authors.lastname: Derval
authors.forename: Sebastien
authors.initials: S
authors.lastname: Knecht
authors.forename: Frederic
authors.initials: F
authors.lastname: Sacher
authors.forename: Pierre
authors.initials: P
authors.lastname: Jais
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Narayan
authors.forename: Meleze
authors.initials: M
authors.lastname: Hocini
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D011667:Pulmonary Veins / Q000503:physiopathology*