title: Ultrastructure of acinar cell injuries in experimental acute pancreatitis created by common bile duct ligation.
abstract: Morphogenesis of acute pancreatitis induced by ligation of the common bile duct and the ultrastructure of autolytic transformations of acinar cells were studied. Autolytic changes in acinar cells started from the basal zones and then involved the apical zones. Violation of the zymogen granules integrity, interactions of their contents with the adjacent ultrastructures, destruction (melting) of ultrastructures, and formation of huge autophagosomes play an important role in the development of autolysis. Disordered secretion of zymogen granules (foci of their accumulation in the apical zone), hyperplasia and hypertrophy of centroacinar cells and ductal epitheliocytes aimed at restoration of the pancreatic secretion discharge pathways were seen in the retained acini.
authors.affiliation: Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: V G
authors.initials: VG
authors.lastname: Viskunov
authors.forename: S I
authors.initials: SI
authors.lastname: Protsenko
authors.forename: O P
authors.initials: OP
authors.lastname: Molodykh
authors.forename: E V
authors.initials: EV
authors.lastname: Koldysheva
mesh_terms: D061354:Acinar Cells / Q000648:ultrastructure*; D000818:Animals; D001329:Autolysis / Q000378:metabolism; D001343:Autophagy / Q000502:physiology; D003135:Common Bile Duct / Q000601:surgery*; D006965:Hyperplasia / Q000473:pathology; D006984:Hypertrophy / Q000473:pathology; D010179:Pancreas / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010195:Pancreatitis / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D022142:Secretory Vesicles / Q000378:metabolism