title: PEG-b-PCL and PEG-b-PLA polymeric micelles as nanocarrieres for lamellarin N delivery.
abstract: Lamellarin N (Lam N) is a member of an interesting marine natural product class isolated from mollusks and subsequently found in ascidians and sponges. The limited aqueous solubility of Lam N hinders further studies on its cytotoxic activity against cancer cells. In this study, micelles comprising poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(D, L-lactide) (PEG-b-PLA) were developed to circumvent Lam N limited aqueous solubility. The results showed that an increase in the molecular weight of both core materials resulted in higher Lam N loading content, whereas the release of Lam N decreased as a function of molecular weight of PCL and PLA. With less hydrophobic property, PLA micelles provided faster Lam N release. Thus, polymeric micelles could be utilized as controlled-release delivery systems for poorly water soluble Lam N.
authors.affiliation: Biomedical Engineering Department, Mahidol University, Nakorn Pathom 73170, Thailand.
authors.forename: Hathaichanok
authors.initials: H
authors.lastname: Pungkham
authors.forename: Nattharin
authors.initials: N
authors.lastname: Swatdipakdi
authors.forename: Man
authors.initials: M
authors.lastname: Theerasilp
authors.forename: Supattra
authors.initials: S
authors.lastname: Karnkla
authors.forename: Montakarn
authors.initials: M
authors.lastname: Chittchang
authors.forename: Poonsakdi
authors.initials: P
authors.lastname: Ploypradith
authors.forename: Norased
authors.initials: N
authors.lastname: Nasongkla
mesh_terms: D004337:Drug Carriers; D008823:Micelles; D049329:Nanostructures; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011092:Polyethylene Glycols