title: Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs.
abstract: Pyroglutamic aciduria is a rare and probably under-recognised cause of metabolic acidosis which may be precipitated by certain common drugs.
authors.affiliation: Department of Clinical Biochemistry, Royal Victoria Hospital, Belfast BT12 6BA. janet.chestnutt@belfasttrust.hscni.net
authors.forename: J
authors.initials: J
authors.lastname: Chestnutt
authors.forename: G
authors.initials: G
authors.lastname: Heyburn
authors.forename: B
authors.initials: B
authors.lastname: Roberts
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000139:chemically induced* / Q000652:urine; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001178:Arthroplasty / Q000009:adverse effects; D016903:Drug Monitoring; D057915:Drug Substitution; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000009:adverse effects*; D006620:Hip Fractures / Q000601:surgery; D006801:Humans; D011761:Pyrrolidonecarboxylic Acid / Q000032:analysis*; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000082:Acetaminophen; D005436:Floxacillin; D011761:Pyrrolidonecarboxylic Acid