title: Rational approaches to improving selectivity in drug design.
authors.affiliation: Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, United Kingdom. djh210@cam.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Huggins
authors.forename: Woody
authors.initials: W
authors.lastname: Sherman
authors.forename: Bruce
authors.initials: B
authors.lastname: Tidor
mesh_terms: D000495:Allosteric Site; D015195:Drug Design; D008958:Models, Molecular; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins; D014867:Water