title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.
abstract: The production of hesperetin glycosides was investigated using glycosylation with Xanthomonas campestris and cyclodextrin glucanotransferase (CGTase). X. campestris glucosylated hesperetin to its 3'-, 5-, and 7-O-glucosides, and CGTase converted hesperetin glucosides into the corresponding maltosides. The resulting 7-O-glucoside and 7-O-maltoside of hesperetin showed inhibitory effects on IgE antibody production and on O2- generation from rat neutrophils.
authors.affiliation: Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan. shimoda@med.oita-u.ac.jp
authors.forename: Kei
authors.initials: K
authors.lastname: Shimoda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
mesh_terms: D000818:Animals; D005964:Glucosyltransferases / Q000378:metabolism*; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D006031:Glycosylation; D006569:Hesperidin / Q000737:chemistry / Q000378:metabolism*; D007073:Immunoglobulin E / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D016959:Xanthomonas campestris / Q000378:metabolism*
chemical_list: D006027:Glycosides; D007073:Immunoglobulin E; D006569:Hesperidin; D005964:Glucosyltransferases; C019963:cyclomaltodextrin glucanotransferase; C013015:hesperetin