title: Changes in blood lymphocyte enzyme profile in patients with renal cancer after a course of interferon therapy.
abstract: Activities of NAD(P)-dependent dehydrogenases in blood lymphocytes of patients with renal cell cancer were studied. The enzyme profiles in patients were different before and after the course of immunotherapy. A relationship between changes in the enzyme status and in vitro cell sensitivity to IFN-α2a was detected.
authors.affiliation: V. F. Voino-Yasenetsky State Medical University, Krasnoyarsk, Russia. aids@ktk.ru
authors.forename: L M
authors.initials: LM
authors.lastname: Kurtasova
authors.forename: N S
authors.initials: NS
authors.lastname: Khvat
authors.forename: A A
authors.initials: AA
authors.lastname: Savchenko
mesh_terms: D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D007372:Interferons / Q000627:therapeutic use*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008214:Lymphocytes / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D007372:Interferons; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005969:Glutamate Dehydrogenase; D005980:Glutathione Reductase