title: Protocadherin-10 is involved in angiogenesis and methylation correlated             with multiple myeloma.
abstract: Protocadherin-10 (PCDH10) which is located at 4q28.3, is a member of the             cadherin superfamily of cell adhesion molecules. PCDH10 is broadly expressed in             normal adult, but nearly undetectable in multiple myeloma (ΜΜ) tissues and cell             lines. Its promoter methylation was detected in virtually all the silenced or             downregulated cell lines. The silencing of PCDH10 could be reversed by pharmacological             demethylation, indicating a methylation-mediated mechanism. In the current study,             we investigated 44 patients (23 females, 21 males), 77.27% (34/44) of whom presented             high methylation of PCDH10. We found no associations between promoter hypermethylation             and gender or age at the time of initial diagnosis. We also examined the role             of PCDH10 as a mediator of MM cell proliferation, cell cycle progression, and             its involvement in angiogenesis. Our results demonstrate that the PCDH10 gene             is a target for epigenetic silencing in MM and provide a link between the dysregulation             of angiogenesis and DNA methylation.
authors.affiliation: Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Ze-song
authors.initials: ZS
authors.lastname: Yang
authors.forename: Jun-jun
authors.initials: JJ
authors.lastname: Song
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.forename: Jian-bin
authors.initials: JB
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D019175:DNA Methylation; D015536:Down-Regulation; D044127:Epigenesis, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics; D009389:Neovascularization, Pathologic; D011401:Promoter Regions, Genetic; D000091363:Protocadherins
chemical_list: D015820:Cadherins; C438603:PCDH10 protein, human; D000091363:Protocadherins