title: Probing for cortical excitability.
abstract: This paper introduces a new method for measuring cortical excitability using an electrical probing stimulus via intracranial electroencephalography (iEEG). Stimuli consisted of 100 single bi-phasic pulses, delivered every 10 minutes. Neural excitability is estimated by extracting a feature from the iEEG responses to the stimuli, which we dub the mean phase variance (PV). We show that the mean PV increases with the rate of inter-ictal discharges in one patient. In another patient, we show that the mean PV changes with sleep and an epileptic seizure. The results demonstrate a proof-of-principal for the method to be applied in a seizure anticipation framework.
authors.affiliation: Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Dean R
authors.initials: DR
authors.lastname: Freestone
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Burkitt
authors.forename: Alan
authors.initials: A
authors.lastname: Lai
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Nelson
authors.forename: David B
authors.initials: DB
authors.lastname: Grayden
authors.forename: Simon
authors.initials: S
authors.lastname: Vogrin
authors.forename: Michael
authors.initials: M
authors.lastname: Murphy
authors.forename: Wendyl
authors.initials: W
authors.lastname: D'Souza
authors.forename: Radwa
authors.initials: R
authors.lastname: Badawy
authors.forename: Levin
authors.initials: L
authors.lastname: Kuhlmann
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cook
mesh_terms: D000465:Algorithms; D002540:Cerebral Cortex / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity