title: Predicting orally disintegrating tablets formulations of ibuprophen tablets: an application of the new SeDeM-ODT expert system.
abstract: This article provides a new innovative tool for pharmaceutical preformulation to predict whether a disintegrant excipient or mixture of powder containing API+excipients is suitable to obtain a bucodispersible tablet by direct compression or not. This innovative tool is the new model SeDeM-ODT that provides the Index of Good Compressibility and Bucodispersibility (IGCB index), which is based on the previous SeDeM expert system that indicates the aptitude of a powder to be compressed. The IGCB index is composed of six main factors (from 15 pharmaceutical raw parameters), which indicate whether a mixture of powder has the aptitude to be compressed by direct compression and at the same time indicates whether these tablets are suitable to be used as a bucodispersible tablet (disintegration time lower than 3 min).
authors.affiliation: Manufacturing Science & Technology Manager, Novartis Pharmaceutical-Spain, Barcelona, Spain.
authors.forename: Johnny Edward
authors.initials: JE
authors.lastname: Aguilar-Díaz
authors.forename: Encarna
authors.initials: E
authors.lastname: García-Montoya
authors.forename: José María
authors.initials: JM
authors.lastname: Suñe-Negre
authors.forename: Pilar
authors.initials: P
authors.lastname: Pérez-Lozano
authors.forename: Montserrat
authors.initials: M
authors.lastname: Miñarro
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Ticó
mesh_terms: D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D005103:Expert Systems; D007052:Ibuprofen / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D013607:Tablets / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D011208:Powders; D013607:Tablets; D007052:Ibuprofen