title: The importance of rheological parameters in the therapy of the dry form of age-related macular degeneration with rheohaemapheresis.
abstract: To date, rheological treatment is the only chance to control the advanced dry form of age-related macular degeneration and arrest its progression to legal blindness. Rheohaemapheresis can change the main rheological parameters, blood and plasma viscosity, as well as change erythrocyte aggregability, improve erythrocyte flexibility and lead to substantial improvement when other methods of therapy fail. In this study, we describe changes in the levels of rheological efficacy indicators after rheohaemapheresis and their clinical significance in the dry form of age-related macular degeneration (AMD). Seventy-two patients with AMD were randomised; 34 controls, and 38 patients were treated with rheohaemapheresis (separator Cobe Spectra + Evaflux filter). After the procedures, α2-macroglobulin levels decreased by approximately 58%, fibrinogen by approximately 65%, IgM by approximately 67%, LDL cholesterol by approximately 71%, apolipoprotein B by approximately 65%, and lipoprotein (a) by approximately 42%. These decreases correspond with a decrease in blood and plasma viscosity (14/12%), clinical improvement (arrest of disease progression, even visual improvement in some cases), and heretofore-unreported improvement (even reattachment) of drusen retinal pigment epithelium detachment. Our modification of rheohaemapheresis is safe (5.4% of patients experienced clinically insignificant side effects).
authors.affiliation: IInd Department of Internal Medicine, Haematology, Charles University, Hradec Králové, Czech Republic. blaham@email.cz
authors.forename: Milan
authors.initials: M
authors.lastname: Bláha
authors.forename: Eva
authors.initials: E
authors.lastname: Rencová
authors.forename: Hana
authors.initials: H
authors.lastname: Langrová
authors.forename: Miriam
authors.initials: M
authors.lastname: Lánská
authors.forename: Vladimír
authors.initials: V
authors.lastname: Bláha
authors.forename: Jan
authors.initials: J
authors.lastname: Studnička
authors.forename: Pavel
authors.initials: P
authors.lastname: Rozsíval
authors.forename: Radovan
authors.initials: R
authors.lastname: Malý
authors.forename: Ilona
authors.initials: I
authors.lastname: Fátorová
authors.forename: Stanislav
authors.initials: S
authors.lastname: Filip
authors.forename: Jakub
authors.initials: J
authors.lastname: Dršata
authors.forename: Libor
authors.initials: L
authors.lastname: Hejsek
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Malý
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001781:Blood Component Removal / Q000379:methods*; D001809:Blood Viscosity; D005260:Female; D057092:Geographic Atrophy / Q000097:blood / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015593:Retinal Drusen / Q000628:therapy; D012212:Rheology; D014792:Visual Acuity; D000511:alpha-Macroglobulins
chemical_list: D000511:alpha-Macroglobulins