title: Developing implantable neuroprosthetics: a new model in pig.
abstract: A new model has been established in the domestic pig for neural prosthetic device development and testing. To this end, we report on a complete neural prosthetic developmental system using a wireless sensor as the implant, a pig as the animal model, and a novel data acquisition paradigm for actuator control. A new type of stereotactic frame with clinically-inspired fixations pins that place the pig brain in standard surgical plane was developed and tested with success during the implantation of the microsystem. The microsystem implanted was an ultra-low power (12.5 mW) 16-channel intracortical/epicranial device transmitting broadband (40 kS/s) data over a wireless infrared telemetric link. Pigs were implanted and neural data was collected over a period of 5 weeks, clearly showing single unit spiking activity.
authors.affiliation: School of Engineering, Brown University, Providence, RI 02912, USA. david borton@brown.edu
authors.forename: David
authors.initials: D
authors.lastname: Borton
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
authors.forename: Juan
authors.initials: J
authors.lastname: Aceros
authors.forename: Naubahar
authors.initials: N
authors.lastname: Agha
authors.forename: Juri
authors.initials: J
authors.lastname: Minxha
authors.forename: Jacob
authors.initials: J
authors.lastname: Komar
authors.forename: William
authors.initials: W
authors.lastname: Patterson
authors.forename: Christopher
authors.initials: C
authors.lastname: Bull
authors.forename: Arto
authors.initials: A
authors.lastname: Nurmikko
mesh_terms: D000818:Animals; D019736:Prostheses and Implants; D013552:Swine