title: Applications of arterial spin labeled MRI in the brain.
abstract: Perfusion provides oxygen and nutrients to tissues and is closely tied to tissue function while disorders of perfusion are major sources of medical morbidity and mortality. It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. While initial ASL magnetic resonance imaging (MRI) studies focused primarily on technological development and validation, a number of robust ASL implementations have emerged, and ASL MRI is now also available commercially on several platforms. As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care.
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. detre@mail.med.upenn.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Hengyi
authors.initials: H
authors.lastname: Rao
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
authors.forename: Yu Fen
authors.initials: YF
authors.lastname: Chen
authors.forename: Ze
authors.initials: Z
authors.lastname: Wang
mesh_terms: D001158:Arteries; D016477:Artifacts; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013113:Spin Labels
chemical_list: D013113:Spin Labels