title: Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases.
abstract: Sixty-three dogs with multiple contemporaneous cutaneous mast cell tumours (MCTs) were identified. The aim of this study was to determine the significance of breed, concurrent dermatological condition; number of cutaneous MCTs, size, location, histological grade and mitotic index; completeness of excision (complete, close or incomplete); local recurrence, metastasis and adjuvant therapy for the prognostic evaluation of dogs with a unique disease presentation of multiple, simultaneously occurring cutaneous MCTs. On the basis of multivariable survival analysis, dogs with one recorded grade 3 MCT had shorter progression-free survival (PFS) times (18.7 versus 2.2 months) and median survival times (MSTs) (24 versus 3 months). Dogs treated with adjuvant vinblastine/lomustine had a 16 times increased risk of dying. MSTs were found to be significantly longer in dogs with one recorded MCT on an extremity. For all dogs, the PFS (range 14-1835 days) and MSTs (range 28-1835 days) were not reached.
authors.affiliation: The Springwood Centre, Cnr Lexington and Logan Roads, Underwood, QLD, Australia. koconnell@vss.net.au
authors.forename: K
authors.initials: K
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Thomson
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D034801:Mastocytoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*