title: Calibrating the photo-thermal response of magneto-fluorescent gold nanoshells.
abstract: We report the photothermal response and Near Infrared (NIR) imaging sensitivities of magneto-fluorescent silica core gold nanocomplexes designed for molecular image guided thermal therapy of cancer. Approximately 160 nm Silica core gold nanoshells were designed to provide NIR fluorescent and Magnetic Resonance (MR) contrast by incorporating FDA approved dye indocyanine green (ICG) and iron-oxide within an outer silica epilayer. The imaging and therapeutic sensitivity, and the stability of fluorescence contrast for 12 microliters of suspension (containing approximately 7.9 × 10(8) or 1.3 femtoMole nanoshells) buried at depths of 2-8 mm in tissue mimicking scattering media is reported.
authors.affiliation: Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, TX 77030, USA. biswal@bcm.edu
authors.forename: Nrusingh C
authors.initials: NC
authors.lastname: Biswal
authors.forename: Ciceron
authors.initials: C
authors.lastname: Ayala-Orzoco
authors.forename: Naomi J
authors.initials: NJ
authors.lastname: Halas
authors.forename: Amit
authors.initials: A
authors.lastname: Joshi
mesh_terms: D002138:Calibration; D005290:Ferric Compounds / Q000737:chemistry; D005453:Fluorescence; D006046:Gold / Q000737:chemistry*; D007208:Indocyanine Green / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D049329:Nanostructures
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D006046:Gold; D007208:Indocyanine Green