title: Mechanisms of hemostimulating effects of granulocytic CSF and pantohematogen under conditions of cytostatic myelosuppression.
abstract: We compared hemostimulating activity of pantohematogen and granulocytic CSF under conditions of 5-fluorouracil-induced cytostatic myelosuppression. It was found that activation of hemopoiesis regeneration under the effect of the test preparations was accompanied by the development of hyperplasia of the granulocytic and monocytic hemopoietic bone marrow lineages and more rapid recovery of the count of pholymorphonuclear leukocytes and monocytes in the peripheral blood (more marked under the effect of pantohematogen) followed by neutrophilia and monocytosis.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: V V
authors.initials: VV
authors.lastname: Shdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: V E
authors.initials: VE
authors.lastname: Goldberg
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006965:Hyperplasia; D007958:Leukocyte Count; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils
chemical_list: D001685:Biological Factors; C404022:pantohematogen; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003520:Cyclophosphamide; D005472:Fluorouracil