title: Antifungal efficacy of soft contact lens disinfecting solutions against Fusarium solani and Candida albicans.
abstract: OBJECTIVE
  The aim was to evaluate the disinfection properties of six multi-purpose contact lens disinfection solutions (MPDS) available in Iran against Fusarium solani and Candida albicans, based on the International Organization for Standardization (ISO) 14729 guidelines.
  
  
  METHODS
  Three lots each of six multi-purpose solutions, namely, Renu MultiPlus, Solo Care Aqua, All-Clean soft, Contact All In One Advanced, Hippia, Ginza Multi-Purpose Solution and 0.9% normal saline solution were inoculated with standard strains of Fusarium solani (ATCC 36031) and Candida albicans (ATCC 10231). Surviving fungi were determined by counting colony-forming units on recovery plates at specified times. The mean log reduction in fungal numbers at the manufacturer's minimum recommended disinfection time was determined and compared with the criteria for stand-alone disinfection products for each MPDS against each fungal strain.
  
  
  RESULTS
  Renu MultiPlus, Contact All In One Advanced and All-Clean Soft were effective in achieving the mean 1.0 log reduction in fungal numbers, based on ISO 14729 stand-alone primary acceptance criteria. Solo Care Aqua failed to achieve the ISO 14729 stand-alone primary acceptance criteria for Candida albicans. The other solutions were not effective against test microorganisms after the specified times.
  
  
  CONCLUSIONS
  There were differences in the rates of disinfection efficacy. Generally, Renu MultiPlus, Contact All In One Advanced and All-Clean Soft exceeded the primary acceptance criteria of the ISO 14729 guidelines for stand-alone contact lens solutions.
authors.affiliation: College of Rehabilitation, Department of Optometry, Shahid Beheshti University Medical Science, Teheran, Iran.
authors.forename: Mohadeseh
authors.initials: M
authors.lastname: Mohammadinia
authors.forename: Mohammad Aghazadeh
authors.initials: MA
authors.lastname: Amiri
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Delavari
authors.forename: Bahman
authors.initials: B
authors.lastname: Yousefzadeh
authors.forename: Maryam Heydarpour
authors.initials: MH
authors.lastname: Maymeh
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000517:prevention & control*; D018639:Contact Lens Solutions / Q000494:pharmacology* / Q000592:standards; D003263:Contact Lenses, Hydrophilic / Q000382:microbiology*; D060585:Fusariosis / Q000517:prevention & control*; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development; D017408:Guidelines as Topic; D006801:Humans; D007492:Iran; D013997:Time Factors
chemical_list: D018639:Contact Lens Solutions