title: Ubiquitin and assembly of export competent mRNP.
abstract: The production of mature and export competent mRNP (mRNA ribonucleoprotein) complexes depends on a series of highly coordinated processing reactions. RNA polymerase II (RNAPII) plays a central role in this process by mediating the sequential recruitment of mRNA maturation and export factors to transcribing genes, thereby establishing a strong functional link between transcription and export through nuclear pore complexes (NPC). Growing evidence indicates that post-translational modifications participate in the dynamic association of processing and export factors with mRNAs ensuring that the transitions and rearrangements undergone by the mRNP occur at the right time and place. This review mainly focuses on the role of ubiquitin conjugation in controlling mRNP assembly and quality control from transcription down to export through the NPC. It emphasizes the central role of ubiquitylation in organizing the chronology of events along this highly dynamic pathway. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.
authors.affiliation: Institut Jacques Monod, Université Paris Diderot, CNRS, Bâtiment Buffon, 15 rue Hélène Brion, 75205 Paris Cedex 13, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Babour
authors.forename: Catherine
authors.initials: C
authors.lastname: Dargemont
authors.forename: Françoise
authors.initials: F
authors.lastname: Stutz
mesh_terms: D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D022022:Nuclear Pore / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D034443:RNA Transport / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism; D054875:Ubiquitination / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; D025801:Ubiquitin; C026452:messenger ribonucleoprotein; D012319:RNA Polymerase II