title: A modelling study on transmission of the central oscillator in tremor by a motor neuron pool.
abstract: In spite of decades of intense research, pathological tremors still constitute unknown disorders. This study addresses, based on a multi-scale model, the behavior of an entire pool of motor neurons in tremor, under the hypothesis that tremor is an oscillation of central origin commonly projected to all motor neurons that innervate a muscle. Our results show that under such conditions both paired discharges and enhanced motor neuron synchronization, two of the characteristic landmarks of tremor, emerge. Moreover, coherence and correlation analyses suggest that the central tremor oscillator is transmitted linearly by the motor neuron pool given that a small set (7 or 8) of motor neurons are sampled.
authors.affiliation: Bioengineering Group, Consejo Superior de Investigaciones Científicas, CSIC, Arganda del Rey, Madrid, Spain. ja.gallego@csic.es
authors.forename: J A
authors.initials: JA
authors.lastname: Gallego
authors.forename: J L
authors.initials: JL
authors.lastname: Dideriksen
authors.forename: D
authors.initials: D
authors.lastname: Farina
authors.forename: E
authors.initials: E
authors.lastname: Rocon
authors.forename: A
authors.initials: A
authors.lastname: Holobar
authors.forename: J L
authors.initials: JL
authors.lastname: Pons
mesh_terms: D001683:Biological Clocks; D003198:Computer Simulation; D056966:Excitation Contraction Coupling; D006801:Humans; D008959:Models, Neurological; D009046:Motor Neurons; D009415:Nerve Net / Q000503:physiopathology; D009469:Neuromuscular Junction; D009435:Synaptic Transmission; D014202:Tremor / Q000503:physiopathology*