title: A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.
abstract: Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management. Coumarins are the phytochemicals with wide range of biological activities including AChE inhibition. The scientists have attempted to explore the coumarin template for synthesizing novel AChE inhibitors with additional pharmacological activities including decrease in beta-amyloid (Aβ) deposition and beta-secretase inhibition that are also important for AD management. Most of the designed schemes have involved incorporation of a catalytic site interacting moiety at 3- and 4-positions of the coumarin ring. The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD.
authors.affiliation: Department of Chemistry, Punjabi University, Patiala 147002, Punjab, India.
authors.forename: Preet
authors.initials: P
authors.lastname: Anand
authors.forename: Baldev
authors.initials: B
authors.lastname: Singh
authors.forename: Nirmal
authors.initials: N
authors.lastname: Singh
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008958:Models, Molecular
chemical_list: D002800:Cholinesterase Inhibitors; D003374:Coumarins; D000110:Acetylcholinesterase