title: [Hypertrophic pulmonary osteoarthropathy as a cue for NSCLC: four cases in the light of the current literature].
abstract: Hypertrophic pulmonary osteoarthropathy (often referred to as Marie-Bamberger syndrome) occurs in 1 - 5 % of all patients with non-small cell lung cancer (NSCLC) as a paraneoplastic syndrome. The complete syndrome is characterised by clubbing of the fingers and toes (often without hypoxia) and pain in the joints and tubular bones. On the basis of four clinical cases, this article shows that this syndrome can precede tumour-specific symptoms and that it is still often overlooked by physicians. An early suspicion of this syndrome is of great clinical value because it can lead to a diagnosis of NSCLC at an earlier tumour stage. In addition to the case reports, the current literature on hypertrophic pulmonary osteoarthropathy is reviewed in this article, with special reference to pathogenetic concepts und to therapeutic options.
authors.affiliation: Abteilung für Pneumologie, Universität Rostock. marek.lommatzsch@med.unirostock.de
authors.forename: M
authors.initials: M
authors.lastname: Lommatzsch
authors.forename: P
authors.initials: P
authors.lastname: Julius
authors.forename: W
authors.initials: W
authors.lastname: Lück
authors.forename: A
authors.initials: A
authors.lastname: Bier
authors.forename: J C
authors.initials: JC
authors.lastname: Virchow
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D001999:Bronchoscopy; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D011379:Prognosis; D014057:Tomography, X-Ray Computed