title: Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.
abstract: Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage.
authors.affiliation: Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Naudi
authors.forename: Mariona
authors.initials: M
authors.lastname: Jove
authors.forename: Victoria
authors.initials: V
authors.lastname: Ayala
authors.forename: Anna
authors.initials: A
authors.lastname: Cassanye
authors.forename: Jose
authors.initials: J
authors.lastname: Serrano
authors.forename: Hugo
authors.initials: H
authors.lastname: Gonzalo
authors.forename: Jordi
authors.initials: J
authors.lastname: Boada
authors.forename: Joan
authors.initials: J
authors.lastname: Prat
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otin
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation; D015398:Signal Transduction; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D013481:Superoxides