title: Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography.
abstract: Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives. The electrostatic force between the analytes and the cationic moiety on β-CD derivative was found to be important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. It was also found that the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions.
authors.affiliation: Division of Chemical and Biomolecular Engineering, College of Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
authors.forename: Ren-Qi
authors.initials: RQ
authors.lastname: Wang
authors.forename: Teng-Teng
authors.initials: TT
authors.lastname: Ong
authors.forename: Siu-Choon
authors.initials: SC
authors.lastname: Ng
mesh_terms: D000596:Amino Acids / Q000032:analysis / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D044950:Flavanones / Q000032:analysis / Q000737:chemistry; D052578:Ionic Liquids; D055672:Static Electricity; D013237:Stereoisomerism; D049971:Thiazides / Q000032:analysis / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002412:Cations; D044950:Flavanones; D052578:Ionic Liquids; D049971:Thiazides; D047392:beta-Cyclodextrins