title: A dual Kalman filter for parameter-state estimation in real-time DNA microarrays.
abstract: Affinity-based biosensors rely on chemical attraction between analytes (targets) and their molecular complements (probes) to detect presence and quantify amounts of the analytes of interest. Real-time DNA microarrays acquire multiple temporal samples of the target-probe binding process. In this paper, estimation of the amount of targets based on early kinetics of the binding reaction is studied. A dual Kalman filter for the parameter-state estimation is proposed. Computational studies demonstrate efficacy of the proposed method.
authors.forename: Manohar
authors.initials: M
authors.lastname: Shamaiah
authors.forename: Haris
authors.initials: H
authors.lastname: Vikalo
mesh_terms: D000465:Algorithms; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*