title: New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation.
abstract: Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)(t)Bu(2)] (1) and [(PMDETA)LiZn(t)Bu(3)] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C-H alkylation of this sensitive heterocycle.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Baillie
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Blair
authors.forename: David C
authors.initials: DC
authors.lastname: Blakemore
authors.forename: Duncan
authors.initials: D
authors.lastname: Hay
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: David C
authors.initials: DC
authors.lastname: Pryde
authors.forename: Eva
authors.initials: E
authors.lastname: Hevia
mesh_terms: D000478:Alkylation; D006571:Heterocyclic Compounds / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011522:Protons; D011719:Pyrazines / Q000737:chemistry*; D013696:Temperature; D015040:Zirconium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D011522:Protons; D011719:Pyrazines; C477680:lithium zirconate; D008094:Lithium; D015040:Zirconium