title: [The role of N-terminal fragment of brain natriuretic peptide in patients with chronic cardiac insufficiency of ischemic genesis].
abstract: The role of N-terminal pro-brain natriuretic peptide (NT-PBP) was analysed in 69 patients with chronic cardiac insufficiency (CCI) of ischemic genesis who developed CCI symptoms after myocardial infarction with the Q-wave on ECG and signed the informed consent. The NT-PBP level was determined in an immunoenzyme assay using Biomedica kits (Slovakia). Statistical treatment of the data was performed with the help of Statistica 7.0 program. The NT-PBP level positively correlated (p < 0.05) with patients' age (r = 0.35) and BMI (r = 0.38), heart rate (r = 0.55), CCI functional class (r = 0.46), CRP level (r = 0.55), left auricle end systolic size (r = 0.53), left ventricle end diastolic size (r = 0.40), left ventricle end diastolic and systolic end volume (r = 0.39 and 0.38), systoloc pressure in the pulmonary artery (r = 0.62), left ventricular myocardial mass (r = 0.58). NT-PBP negatively correlated (p < 0.05) with ejection fraction (r = -0.54). Based on NGT-PBP median, the patients were divided into 2 groups. Group 1 (n = 35) and group 2 (n = 34) comprised patients with NT-PBP levels below and above 120 pmol/ml respectively. Patients of group 2 were significantly older than in group 1 (p = 0.04), had a larger number of previous myocardial infarctions (p = 0.01), more frequent manifestations of CCI (p = 0.04), higher heart rate (p = 0.003) and CRP level (p = 0.005). Patients of group 2 had more frequent adverse events (p = 0.03), increased cholesterol level (p = 0.03), repeated myocardial infarction (p = 0.02), and fatal outcomes (p = 0.01).
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis / Q000097:blood*; D010446:Peptide Fragments / Q000096:biosynthesis / Q000097:blood*; D013318:Stroke Volume / Q000502:physiology
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain