title: Clinical and single-photon emission computed tomography study of pure akinesia with freezing of gait.
abstract: The clinical syndrome of pure akinesia (PA) is considered the third phenotype of progressive supranuclear palsy (PSP), and is characterized by freezing of gait and prominent speech disturbance without rigidity or tremor. It is frequently considered one of the dopamine resistant motor syndromes, and its pathophysiology remains unclear. We report a patient followed in the Department of Neurology of Razi Hospital, Tunisia, with PA with gait freezing (PAGF) with a frontal hypoperfusion on single photon emission CT and non-responsive dopa therapy. We discuss the clinical features of PAGF and efficiency of treatment options.
authors.affiliation: Clinical Neurophysiology and Electrodiagnosis Unit, Department of Neurology, Razi Hospital, La Manouba, Tunisia.
authors.forename: Imen
authors.initials: I
authors.lastname: Kacem
authors.forename: Amina
authors.initials: A
authors.lastname: Gargouri
authors.forename: Mouna
authors.initials: M
authors.lastname: Ben-Djebara
authors.forename: Riadh
authors.initials: R
authors.lastname: Gouider
mesh_terms: D003937:Diagnosis, Differential; D015259:Dopamine Agents / Q000627:therapeutic use; D020235:Gait Apraxia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000534:rehabilitation; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009018:Morocco; D013064:Speech Disorders / Q000209:etiology; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000534:rehabilitation; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015259:Dopamine Agents; D007980:Levodopa