title: Cytopathologic analysis of stroma-poor salivary gland epithelial/myoepithelial neoplasms on fine needle aspiration.
abstract: OBJECTIVE
  Fine needle aspiration (FNA) diagnosis of salivary gland neoplasms with epithelial/myoepithelial cells but rare or no stroma is usually difficult. Our aim was to study the cytomorphology of this cohort of FNA cases and evaluate the clinical follow-up.
  
  
  METHODS
  The diagnostic terminology for this group of aspirates was 'favor an epithelial/myoepithelial neoplasm of the salivary gland'. The cytologic smears of 32 such cases were retrieved and showed cellular smears with bland-appearing or mildly atypical epithelial and myoepithelial cells without typical chondromyxoid stroma seen in pleomorphic adenoma (PA).
  
  
  RESULTS
  Twenty of the 32 cases had histologic follow-up. Ten of these 20 cases were PAs, including 8 cellular PAs. Two cases were basal cell adenomas, 1 case myoepithelioma and 1 case benign adenoma, not otherwise specified. Among the 6 malignant tumors on surgical resections, there were 3 epithelial-myoepithelial carcinomas, 1 myoepithelial carcinoma, 1 basal cell adenocarcinoma and 1 adenoid cystic carcinoma.
  
  
  CONCLUSIONS
  Although 14 of the 20 (70%) cases were benign neoplasms, a substantial amount of cases (30%) were malignant salivary gland neoplasms. The generic diagnostic terminology of 'epithelial/myoepithelial neoplasm of the salivary gland' and appropriate clinical follow-up are recommended for these cases.
authors.affiliation: Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, Ohio 44195, USA. chenl@ccf.org
authors.forename: Longwen
authors.initials: L
authors.lastname: Chen
authors.forename: Nancy
authors.initials: N
authors.lastname: Ray
authors.forename: Huiying
authors.initials: H
authors.lastname: He
authors.forename: Aaron
authors.initials: A
authors.lastname: Hoschar
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D008949:Adenoma, Pleomorphic / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000175:diagnosis*; D010307:Parotid Neoplasms / Q000175:diagnosis*; D017154:Stromal Cells / Q000473:pathology; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis*