title: Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression.
abstract: SOX11 expression has been recently shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphology. We evaluated SOX11 expression pattern in B-cell non-Hodgkin lymphoma (B-NHL) subtypes to confirm specificity and used it as a feature to identify the first reported cases of cyclin D1-negative blastoid MCL. SOX11 expression was evaluated by immunohistochemistry in 140 cases of mature B-NHL, including 4 cases of suspected blastoid MCL that lacked cyclin D1 expression and 8 cases of CD5-positive diffuse large B-cell lymphoma (DLBL). In addition, 5 cases of B or T lymphoblastic lymphoma were included. Nuclear expression of SOX11 was found in cyclin D1-positive MCL (30/30, 100%) and in a case of cyclin D1-negative MCL with typical morphology. SOX11 was also expressed in Burkitt lymphoma (1/5, 20%) and lymphoblastic lymphoma (2/3 T-LBLs, 2/2 B-LBLs, overall 4/5, 80%), whereas all cases of DLBL (including CD5 DLBL) and other small B-NHL were negative. The 4 suspected cases of blastoid MCL were also SOX11. These cases had a complex karyotype that included 12p abnormalities. We confirmed prior reports that stated that SOX11 nuclear expression was a specific marker for MCL, including cyclin D1-negative MCL with typical morphology. To our knowledge, this is the first report regarding its use in identifying cases of cyclin D1-negative blastoid MCL. Routine use of SOX11 in cases of suspected CD5 DLBL might help identify additional cases of cyclin D1-negative blastoid MCL.
authors.affiliation: Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Weifen
authors.initials: W
authors.lastname: Zeng
authors.forename: Kai
authors.initials: K
authors.lastname: Fu
authors.forename: Leticia
authors.initials: L
authors.lastname: Quintanilla-Fend
authors.forename: Megan
authors.initials: M
authors.lastname: Lim
authors.forename: Sarah
authors.initials: S
authors.lastname: Ondrejka
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019938:Cyclin D1; D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000378:metabolism* / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055751:SOXC Transcription Factors / Q000096:biosynthesis*
chemical_list: C097473:SOX11 protein, human; D055751:SOXC Transcription Factors; D019938:Cyclin D1