title: Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.
abstract: Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigated for their ability to bind with the pre-miRNA target (hsa-mir-155) and thereby to interfere with the Dicer catalyzed miRNA processing. Potential binding and inhibition effects have been demonstrated by some of these analogs. They can be used as leads for further development of potent small molecular miRNA-antagonists.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Mohitosh
authors.initials: M
authors.lastname: Maiti
authors.forename: Koen
authors.initials: K
authors.lastname: Nauwelaerts
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001483:Base Sequence; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional / Q000187:drug effects; D043244:Ribonuclease III / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000970:Antineoplastic Agents; D035683:MicroRNAs; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases