title: Reversal of liver cirrhosis in autoimmune hepatitis.
abstract: Liver cirrhosis is generally considered irreversible but there are reports in which there is documented reversal of fibrosis/cirrhosis in various clinical conditions like Wilson's disease, hemochromatosis, primary biliary cirrhosis and autoimmune hepatitis. The subgroup of patients with autoimmune hepatitis that will have reversal of cirrhosis is not known. We present two cases with documented liver cirrhosis that had reversal of cirrhosis after treatment with immunosuppressive agents. We postulate that patients presenting with acute hepatitis and no other fibrogenic factors have higher chances of reversal of liver cirrhosis as compared to those presenting as chronic liver injury.
authors.affiliation: Department of Internal Medicine, Saint Joseph's Regional Medical Center, Paterson, NJ, USA. anishshah21@gmail.com
authors.forename: Anish M
authors.initials: AM
authors.lastname: Shah
authors.forename: Ashish
authors.initials: A
authors.lastname: Malhotra
authors.forename: Shivangi
authors.initials: S
authors.lastname: Kothari
authors.forename: Walid
authors.initials: W
authors.lastname: Baddoura
authors.forename: Joseph
authors.initials: J
authors.lastname: Depasquale
authors.forename: Robert
authors.initials: R
authors.lastname: Spira
mesh_terms: D000328:Adult; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents