title: Complete remission and long-term survival in a child with relapsed medulloblastoma with extensive osteosclerotic bony metastasis with a novel metronomic chemobiological approach.
abstract: Extraneural metastases in medulloblastoma are rare. We report a boy with medulloblastoma who was initially treated with gross total excision of primary tumor followed by radiotherapy. Six years later, he developed disseminated osteosclerotic bony relapse associated with bone marrow involvement. He was successfully salvaged with metronomic low-dose cyclophosphamide, etoposide, and zoledronic acid. In patients with medulloblastoma and bone pain, metastases to bone should be excluded, and medulloblastoma should be considered while investigating osteosclerotic bone lesions. Furthermore, metronomic chemotherapy should be considered in this setting until better therapeutic modalities emerge.
authors.affiliation: Department of Pediatric Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sondhi
authors.forename: Purna
authors.initials: P
authors.lastname: Arun Kurkure
authors.forename: Rakesh
authors.initials: R
authors.lastname: Jalali
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Rangarajan
authors.forename: Epari
authors.initials: E
authors.lastname: Sridhar
authors.forename: Seema
authors.initials: S
authors.lastname: Medhi
authors.forename: Brijesh
authors.initials: B
authors.lastname: Arora
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D010026:Osteosclerosis / Q000209:etiology*; D012008:Recurrence; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid