title: Roles of long, non-coding RNA in chromosome-wide transcription regulation: lessons from two dosage compensation systems.
abstract: A large part of higher eukaryotic genomes is transcribed into RNAs lacking any significant open reading frame. This "non-coding part" has been shown to actively contribute to regulating gene expression, but the mechanisms are largely unknown. Particularly instructive examples are provided by the dosage compensation systems, which assure that the single X chromosome in male cells and the two X chromosomes in female cells give rise to similar amounts of gene product. Although this is achieved by very different strategies in mammals and fruit flies, long, non-coding RNAs (lncRNAs) are involved in both cases. Here we summarize recent progress towards unraveling the mechanisms, by which the Xist and roX RNAs mediate the selective association of regulators with individual target chromosomes, to initiate dosage compensation in mammals and fruit flies, respectively.
authors.affiliation: Adolf-Butenandt-Institute and Center for Integrated Protein Science (CIPSM), Ludwig Maximilian University Munich, Schillerstrasse 44, 80336 München, Germany. sylvain.maenner@med.uni-muenchen.de
authors.forename: Sylvain
authors.initials: S
authors.lastname: Maenner
authors.forename: Marisa
authors.initials: M
authors.lastname: Müller
authors.forename: Peter B
authors.initials: PB
authors.lastname: Becker
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D004303:Dosage Compensation, Genetic / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D022661:RNA, Untranslated / Q000737:chemistry* / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D022661:RNA, Untranslated