title: A brief note on the resemblance between relatives in the presence of population stratification.
abstract: Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.
authors.affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143-0794, USA. ronnie.sebro@ucsf.edu
authors.forename: R
authors.initials: R
authors.lastname: Sebro
authors.forename: N J
authors.initials: NJ
authors.lastname: Risch
mesh_terms: D005190:Family; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D016045:Human Genome Project; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable