title: A preliminary study of apparent diffusion coefficient in chemotherapy-induced liver damage.
abstract: OBJECTIVE
  To investigate changes in the hepatic apparent diffusion coefficient (ADC) in patients undergoing chemotherapy.
  
  
  METHODS
  We enrolled 54 patients (25 women; mean age 57.0±13.1 years, range 29-89 years) undergoing chemotherapy for tumor and 10 controls (7 women; mean age 55.1±17.5 years, range 23-81 years). The patients were tested for serum alanine aminotransferase (ALT) activity (abnormal, normal) and fatty liver. Hepatic ADC values were compared among controls, patients and subgroups. Pearson correlation coefficient was used to assess the correlation between ADC and ALT activity.
  
  
  RESULTS
  Hepatic ADC0,850 (×10(-3) mm2/s) was lower for patients than controls (1.14±0.18 vs. 1.28±0.12, P=0.02) and was lower for patients with than without fatty liver and controls (1.01±0.06 vs. 1.18±0.18 and 1.28±0.12, respectively, all P<0.01), with no significant difference between patients without fatty liver and controls (P=0.07). ADC0,850 was lower for patients with abnormal ALT than normal ALT activity and controls (0.99±0.06 vs. 1.17±0.18 and 1.28±0.12, respectively, all P<0.05), with a significant difference also being seen between patients with normal ALT activity and controls (P=0.04). Hepatic ADC0,850 was not correlated with ALT activity in patients (r=-0.24, P=0.08).
  
  
  CONCLUSIONS
  Although ADC did not correlate with ALT values, it did distinguish patient likely to have chemotherapy-induced liver damage as indicated by abnormal ALT values or fatty liver. These mechanisms need to be disentangled.
authors.affiliation: Department of Interventional Radiology, Shandong Medical Imaging Research Institute, Shandong University, and Department of Radiology, Hospital Affiliated to Shandong Academy of Medical Science, 38#, Wuyingshan Road, Jinan 250031, Shandong Province, PR China. radiozq@163.com
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Yu
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wen
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Yuan
authors.forename: Zuo-Qin
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000970:Antineoplastic Agents