title: Human umbilical cord mesenchymal stromal cells mitigate chemotherapy-associated tissue injury in a pre-clinical mouse model.
abstract: OBJECTIVE
  Mesenchymal stromal cells (MSC) have been shown to be a promising candidate for tissue regeneration and cancer therapy. However, their therapeutic potential against chemotherapy-induced side-effects remains unclear.
  
  
  METHODS
  We treated murine Lewis lung carcinoma (LLC) and xenograft human colon tumors with adriamycin (ADM) for 3 consecutive days followed by one intravenous (i.v.) injection of human umbilical cord (hUC) MSC for several cycles.
  
  
  RESULTS
  MSC treatment mitigated ADM-induced cardiomyopathy, reduced the extent of ADM-induced apoptosis in intestinal crypts, suppressed body weight loss in mice treated with ADM and increased the survival rate of mice treated with a lethal dose of ADM. The examination of hematologic parameters indicated a moderate recovery in MSC-injected mice. Systemic administration of MSC did not increase the growth of murine LLC cells and human colon carcinoma in vivo while it strongly inhibited the lung metastases of LLC cells.
  
  
  CONCLUSIONS
  We evaluated the prophylactic and therapeutic action of hUC MSC on the chemotherapy agent ADM-induced side-effects in two different tumor models. Our observations suggest that MSC can be used as auxiliary means in chemotherapy for certain tumor types.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
authors.forename: Guo-Hu
authors.initials: GH
authors.lastname: Di
authors.forename: Shu
authors.initials: S
authors.lastname: Jiang
authors.forename: Fu-Quan
authors.initials: FQ
authors.lastname: Li
authors.forename: Jun-Zhong
authors.initials: JZ
authors.lastname: Sun
authors.forename: Chu-Tse
authors.initials: CT
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Duan
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000628:therapy*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000628:therapy*; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D014470:Umbilical Cord / Q000166:cytology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin