title: Dynamic contrast-enhanced magnetic resonance imaging-derived kep as a potential biomarker of matrix metalloproteinase 9 expression in patients with glioblastoma multiforme: a pilot study.
abstract: OBJECTIVE
  To look for the association of tissue matrix metalloproteinase 9 (MMP-9) expression with dynamic contrast-enhanced magnetic resonance imaging and to see whether these can prognosticate patients with glioblastoma multiforme (GBM).
  
  
  METHODS
  Forty-seven patients with GBM underwent dynamic contrast-enhanced magnetic resonance imaging to look for association of its indices with tissue MMP-9 expression using Pearson correlation. Kaplan-Meier survival analysis was performed to study the survival pattern for low-, medium-, and high-tissue MMP-9 expression and kep values.
  
  
  RESULTS
  Among perfusion indices, kep, k, and ve significantly correlated with MMP-9 expression. Matrix metalloproteinase 9 expression was found to be best estimated by kep using a quadratic model. The 1-year survival in low-, medium-, and high-tissue MMP-9 and kep groups were 59%, 45%, and 7%, and 59%, 33%, and 15%, respectively.
  
  
  CONCLUSIONS
  The association of kep and MMP-9 expression with survival suggests that kep may be used as imaging biomarker of GBM progression and its prognostication.
authors.affiliation: Departments of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Awasthi
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Pandey
authors.forename: Prativa
authors.initials: P
authors.lastname: Sahoo
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Vijendra
authors.initials: V
authors.lastname: Kumar
authors.forename: Shaleen
authors.initials: S
authors.lastname: Kumar
authors.forename: Shagun
authors.initials: S
authors.lastname: Misra
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.forename: Priyanka
authors.initials: P
authors.lastname: Soni
authors.forename: Ram K S
authors.initials: RK
authors.lastname: Rathore
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D020780:Matrix Metalloproteinase 9