title: Pancreatic islet cell amyloidosis manifesting as a large pancreas.
abstract: A 39-year-old female patient presented to our hospital with epigastric pain lasting for two months. Laboratory results showed impaired glucose tolerance. Ultrasonography of the patient showed a hypoechoic, diffusely enlarged pancreas. CT revealed a large pancreas, with multiple calcifications. On MRI, a diffusely enlarged pancreas was seen hypointense on both T1- and T2-weighted images with heterogeneous enhancement after gadolinium administration. A biopsy of the pancreas revealed primary amyloidosis of islet cells. Decreased signal on T1-weighted images without inflammation findings on CT and MRI were clues for the diagnosis.
authors.affiliation: Department of Radiology, University of Firat, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119. ruhionur@yahoo.com
authors.forename: Mehmet Ruhi
authors.initials: MR
authors.lastname: Onur
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalnız
authors.forename: Ahmet Kursad
authors.initials: AK
authors.lastname: Poyraz
authors.forename: Ibrahim Hanifi
authors.initials: IH
authors.lastname: Özercan
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozkan
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology*; D010182:Pancreatic Diseases / Q000175:diagnosis*
chemical_list: D003287:Contrast Media