title: Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression.
abstract: Diet and energy metabolism affect gene expression, which influences human health and disease. Here, we discuss the role of epigenetics as a mechanistic link between energy metabolism and control of gene expression. A number of key energy metabolites including SAM, acetyl-CoA, NAD(+), and ATP serve as essential co-factors for many, perhaps most, epigenetic enzymes that regulate DNA methylation, posttranslational histone modifications, and nucleosome position. The relative abundance of these energy metabolites allows a cell to sense its energetic state. And as co-factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate/downregulate transcription as appropriate to maintain homeostasis.
authors.affiliation: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Dallas R
authors.initials: DR
authors.lastname: Donohoe
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Bultman
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics*; D004032:Diet; D004734:Energy Metabolism; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D055432:Metabolomics; D009243:NAD / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000235:genetics; D012436:S-Adenosylmethionine / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones; D009243:NAD; D000105:Acetyl Coenzyme A; D012436:S-Adenosylmethionine; D000255:Adenosine Triphosphate