title: Genetic variation of GPLD1 associates with serum GPI-PLD levels: a preliminary study.
abstract: HDL is a heterogeneous mixture of lipoprotein particles varying in composition, size, and function. We and others have described a small (7.0nm), minor (0.1% of total apolipoprotein AI) particle containing apolipoprotein AI, AIV and glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in humans the function of which is not entirely known. Circulating GPI-PLD levels are regulated by multiple factors including genetics. To determine if genetic variation in GPLD1 affects circulating GPI-PLD levels, we examined the relationship between 32 SNPS upstream, within, and downstream of GPLD1 and circulating GPI-PLD levels in Caucasians (n=77) and African-Americans (n=99). The genotype distribution among races differed at 13 SNPs. Nine SNPS were associated with circulating GPI-PLD levels in Caucasians but not African-Americans. These results suggest that genetic variation of GPLD1 appears to associate with circulating GPI-PLD levels. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010).
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. deegma@lilly.com
authors.forename: Mark A
authors.initials: MA
authors.lastname: Deeg
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Xuei
authors.forename: George
authors.initials: G
authors.lastname: Eckert
authors.forename: Robert V
authors.initials: RV
authors.lastname: Considine
authors.forename: Ying Grace
authors.initials: YG
authors.lastname: Li
authors.forename: J Howard
authors.initials: JH
authors.lastname: Pratt
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010739:Phospholipase D / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D010739:Phospholipase D; C065017:glycoprotein phospholipase D