title: Antioxidant phenolic compounds from the stems of Entada phaseoloides.
abstract: The EtOH extract of the stems of Entada phaseoloides displayed potent antioxidant activity when assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging, reducing power, β-carotene-bleaching, and superoxide radical-scavenging analyses. Fractionation of the EtOH extracts showed that the AcOEt fraction is the most active, followed by the H(2) O fraction, while BuOH fraction was least active. Further activity-guided fractionation studies on the active fractions resulted in the isolation of 22 compounds. The identities of these compounds were established based on extensive spectroscopic studies. Furthermore, the antioxidant activities of the isolated compounds were evaluated by using the above-mentioned five assays. The results demonstrated that the EtOH extract of E. phaseoloides stems exhibits an excellent antioxidant activity and thus presents a great potential as a source of natural antioxidants.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Minhang District, Shanghai 200240, P. R. China.
authors.forename: Yuqiong
authors.initials: Y
authors.lastname: Dong
authors.forename: Haiming
authors.initials: H
authors.lastname: Shi
authors.forename: Haisha
authors.initials: H
authors.lastname: Yang
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Peng
authors.forename: Mengyue
authors.initials: M
authors.lastname: Wang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000975:Antioxidants; D010636:Phenols