title: The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28(-) T-cells. Our aim was to examine whether CD4(+)CD28(-) T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4(+)CD28(-) T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies.
authors.affiliation: Research Laboratory, Hospital Regional Universitario Carlos Haya and Fundación IMABIS, Málaga, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Pinto-Medel
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: García-León
authors.forename: Begoña
authors.initials: B
authors.lastname: Oliver-Martos
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Gómez
authors.forename: Gloria
authors.initials: G
authors.lastname: Luque
authors.forename: Carlos
authors.initials: C
authors.lastname: Arnáiz-Urrutia
authors.forename: Teresa
authors.initials: T
authors.lastname: Orpez
authors.forename: Carmen
authors.initials: C
authors.lastname: Marín-Bañasco
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Leyva
mesh_terms: D000328:Adult; D018106:CD28 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D060908:CTLA-4 Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D055607:Receptors, Natural Killer Cell / Q000378:metabolism; D013030:Spain; D055815:Young Adult; D019014:fas Receptor / Q000378:metabolism
chemical_list: D018106:CD28 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D015815:Cell Adhesion Molecules; D016207:Cytokines; D055607:Receptors, Natural Killer Cell; D019014:fas Receptor