title: [Bronchiolo-alveolar carcinoma and lung transplantation].
abstract: BACKGROUND
  Bronchiolo-alveolar carcinoma is a controversial indication for lung transplantation because of the risk of recurrence. We report three cases and propose some risk factors for recurrence.
  
  
  METHODS
  Our study concerns three patients transplanted at the Louis-Pradel Hospital between 1991 and 2010. The first patient relapsed 86 months after transplantation, benefited from surgical treatment, then died of renal failure. A second patient died of infection, without recurrence, 72 months after transplantation. The third had an early recurrence at 7 months and died 27 months after transplantation. The risk factors for recurrence appear to be: clinically "aggressive" presentation and histological stromal pulmonary invasion by the carcinoma.
  
  
  CONCLUSIONS
  Diffuse bronchiolo-alveolar carcinoma is a possible indication of lung transplantation. The risk of recurrence imposes some requirements: a precise histological diagnosis and a slow clinical course.
authors.affiliation: Services de pneumologie et de chirurgie thoracique, centre de biologie Est, centre de pathologie Est, hôpital Louis-Pradel, hospices civils de Lyon, 28, avenue Doyen-Delépine, 69677 Bron, France.
authors.forename: V
authors.initials: V
authors.lastname: Avrillon
authors.forename: F
authors.initials: F
authors.lastname: Philit
authors.forename: L
authors.initials: L
authors.lastname: Chalabreysse
authors.forename: R W
authors.initials: RW
authors.lastname: Chumbi-Flores
authors.forename: F
authors.initials: F
authors.lastname: Tronc
authors.forename: F
authors.initials: F
authors.lastname: Thivolet-Bejui
authors.forename: J F
authors.initials: JF
authors.lastname: Mornex
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000473:pathology / Q000601:surgery*; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology; D009367:Neoplasm Staging; D012307:Risk Factors