title: A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy.
abstract: Castleman disease (CD) is a rare lymphoproliferative disorder. Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standard therapy for the unicentric form, no consensus has been reached concerning the standard treatment for multicentric CD. We report here a case of cervical multicentric CD treated with intensity-modulated radiation therapy (IMRT), using helical tomotherapy to minimize xerostomia in comparison with conventional radiotherapy. A 29-year-old woman complained of neck swelling. Computed tomography showed lymphadenopathy in both sides of the neck. The patient was diagnosed with the plasma cell subtype of CD on biopsy. After initial treatment with prednisone, IMRT was planned to avoid normal structures, for example the parotid gland. The cervical lymphadenopathy shrank gradually during IMRT with 44 Gy in 22 fractions. Four years and 3 months after IMRT, regrowth of cervical lymph nodes has not been detected. The parotid function improved dramatically on quantitative salivary scintigraphy between 3 and 12 months after IMRT. Radiotherapy could be an option for multicentric CD, and IMRT is an effective means of minimizing xerostomia in head and neck lesions.
authors.affiliation: Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. ntomita@aichi-cc.jp
authors.forename: Natsuo
authors.initials: N
authors.lastname: Tomita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kodaira
authors.forename: Takuya
authors.initials: T
authors.lastname: Tomoda
authors.forename: Kosei
authors.initials: K
authors.lastname: Nakajima
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murao
authors.forename: Kunio
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D009333:Neck; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D036542:Tomography, Spiral Computed; D014987:Xerostomia / Q000517:prevention & control