title: A multicenter study of the clinical characteristics of usual-type vulvar intraepithelial neoplasia in China.
abstract: OBJECTIVE
  To investigate clinical characteristics of usual-type vulvar intraepithelial neoplasia (uVIN) in China.
  
  
  METHODS
  A retrospective review of the records of 64 patients with uVIN was performed at 3 academic hospitals between 2004 and 2010. Patients were assigned to a younger (≤40 years) or an older (>40 years) group. Clinical characteristics of lesions were described and analyzed.
  
  
  RESULTS
  Mean patient age was 40.6 years. There was a high proportion of incidental findings (34%), multifocal lesions (64%), variegated lesions (59%), and multiple neoplastic lesions in the lower genital tract (20%). As patient age increased, so did numbers of patients reporting pain (P<0.05). Longer time between symptom onset and uVIN diagnosis, and more multifocal lesions were noted in the older group (P<0.05). Whereas younger patients often presented with cervical intraepithelial neoplasia and uVIN, older patients often presented with intraepithelial neoplasia at uncommon locations (e.g. vagina, anus, and periurethral region) (P<0.05). No differences between the groups were found regarding gross appearance or anatomic location of uVIN lesions (P>0.05).
  
  
  CONCLUSIONS
  Age-specific differences were noted in location of neoplastic lesions in the lower genital tract and time to diagnosis of uVIN. However, the clinical features of uVIN lesions were heterogeneous and non-age specific.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Zhu
authors.forename: Yu
authors.initials: Y
authors.lastname: Gu
authors.forename: Hangmei
authors.initials: H
authors.lastname: Jin
authors.forename: Changyu
authors.initials: C
authors.lastname: Wang
authors.forename: Jinghe
authors.initials: J
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002278:Carcinoma in Situ / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D016009:Chi-Square Distribution; D002681:China; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis*; D011537:Pruritus / Q000209:etiology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D014846:Vulvar Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral