title: The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H).
abstract: This study compared serum pyridine levels (NAD(+)/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD(+) levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD(+) and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
authors.affiliation: School of Medical Science, University of New South Wales, Kensington, Australia. John.mach@unsw.edu.au
authors.forename: John
authors.initials: J
authors.lastname: Mach
authors.forename: Adrian W
authors.initials: AW
authors.lastname: Midgley
authors.forename: Steve
authors.initials: S
authors.lastname: Dank
authors.forename: Ross S
authors.initials: RS
authors.lastname: Grant
authors.forename: David J
authors.initials: DJ
authors.lastname: Bentley
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005080:Exercise Test; D005221:Fatigue / Q000378:metabolism / Q000503:physiopathology; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011725:Pyridines / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011725:Pyridines; C024070:pycnogenols