title: Multimodal fundus imaging in choroidal osteoma.
abstract: OBJECTIVE
  To describe the morphologic features of calcified and decalcified choroidal osteomas using multimodal imaging and correlate these findings with a previous histopathologic study.
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  Three patients with choroidal osteoma underwent complete ophthalmologic examination, fundus photography, and multimodal fundus imaging, including Fourier-domain optical coherence tomography (FD-OCT) and blue-light fundus autofluorescence (bAF).
  
  
  RESULTS
  FD-OCT imaging of calcified tumors revealed a distinctive latticework pattern of reflectivity resembling the spongy bone structure seen histopathologically. On bAF the fluorescence was relatively well preserved overlying calcified tumors. In decalcified areas 2 patterns of reflectivity were identified: the first consisted of areas of relative hyperreflectivity with a lamellar appearance while the second was characterized by heterogeneous, hyperreflective, mound-like irregular areas associated with some posterior optical shadowing. Decalcified tumor areas had reduced overall fluorescence on bAF.
  
  
  CONCLUSIONS
  FD-OCT demonstrated different reflectivity patterns in both calcified and decalcified portions of the choroidal osteoma, which may correspond to different stages of tumor evolution. A distinctive latticework pattern of reflectivity similar to spongy bone was seen in calcified tumors. These observations improve our knowledge of the in vivo structure of choroidal osteomas and may have implications for the diagnosis and management of this tumor.
authors.affiliation: Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital, University of Toronto, Ontario, Canada. edunavajas@gmail.com
authors.forename: Eduardo V
authors.initials: EV
authors.lastname: Navajas
authors.forename: Rogerio A
authors.initials: RA
authors.lastname: Costa
authors.forename: Daniela
authors.initials: D
authors.lastname: Calucci
authors.forename: Dena S
authors.initials: DS
authors.lastname: Hammoudi
authors.forename: E Rand
authors.initials: ER
authors.lastname: Simpson
authors.forename: Filiberto
authors.initials: F
authors.lastname: Altomare
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology; D002830:Choroid Neoplasms / Q000473:pathology*; D003649:Decalcification, Pathologic / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010016:Osteoma / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity