title: Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver.
abstract: The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on protective effects of magnesium (Mg) or and i.p. pretreatment on the same parameters was performed. Wistar rats were administrated oral dose of Cd (30 mg Cd/kg b.w.)/Cd+Mg (30 mg Cd/kg b.w., 50 mg Mg/kg b.w.) or i.p. dose of Cd (1.5 mg Cd/kg b.w.)/Cd+Mg (1.5 mg Cd/kg b.w., 3 mg Mg/kg b.w.) and sacrificed after 24 h. In liver homogenates superoxide anion, malondialdehyde, non-protein sulfhydryl groups, total sulfhydryl groups content, and superoxide dismutase activity were determined. Cadmium intoxication caused the increase of superoxide anion and malondialdehyde levels and had negative effect on investigated parameters of antioxidant defense system, except on total sulfhydryl groups. The negative effect was more emphasized after i.p. Cd administration. Oral Mg pretreatment induced more pronounced positive effect than Mg given intraperitoneally that can be attributed, at least partly, to Cd and Mg interactions on the level of GIT. On the basis of the obtained results it can be concluded that both Cd and Cd+Mg effects on parameters of oxidative stress in rats liver are route-dependent.
authors.affiliation: Department of Toxicology Akademik Danilo Soldatovic, Faculty of Pharmacy, University of Belgrade, Serbia. vevodi@pharmacy.bg.ac.rs
authors.forename: Vesna
authors.initials: V
authors.lastname: Matović
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Buha
authors.forename: Zorica
authors.initials: Z
authors.lastname: Bulat
authors.forename: Danijela
authors.initials: D
authors.lastname: Ðukić-Ćosić
authors.forename: Milica
authors.initials: M
authors.lastname: Miljković
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ivanišević
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljević
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008274:Magnesium / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002104:Cadmium; D008274:Magnesium