title: A nanoelectromechanical biosensor based on precise quantification and control of DNA orientation.
abstract: We utilize spectral self-interference fluorescent microscopy (SSFM) to measure fluorophore height with sub-nm precision to precisely quantify DNA orientation. A novel polymeric 3D scaffold is used to functionalize the sensor surface and to control orientation of the surface anchored DNA.
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. pspuhler@bu.edu
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Spuhler
authors.forename: Laura
authors.initials: L
authors.lastname: Sola
authors.forename: Xirui
authors.initials: X
authors.lastname: Zhang
authors.forename: Margo
authors.initials: M
authors.lastname: Monroe
authors.forename: Joseph
authors.initials: J
authors.lastname: Greenspun
authors.forename: Marcella
authors.initials: M
authors.lastname: Chiari
authors.forename: M Selim
authors.initials: MS
authors.lastname: Unlu
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D008856:Microscopy, Fluorescence
chemical_list: D004247:DNA