title: Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats.
abstract: The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT) on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group): (1) sedentary (Sed-Intact); (2) sedentary ovariectomized (Sed-Ovx); (3) sedentary nandrolone (Sed-Intact-ND); (4) sedentary ovariectomized plus nandrolone (Sed-Ovx-ND); (5) trained (TR-Intact); (6) trained nandrolone (TR-Intact-ND); (7) trained ovariectomized (TR-Ovx); (8) trained ovariectomized plus nandrolone; (9) trained sham; and (10) trained ovariectomized plus sham. Four sessions of RT were used, during which the animals climbed a 1.1 m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with between four and nine climbs and with eight to twelve dynamic movements per climb. To test the sensitivity of insulin in the pancreas, glucose and insulin tolerance tests were performed. For insulin sensitivity, there was a statistically significant interaction for the TR-Ovx group, which presented higher sensitivity than the Sed-Intact, Sed-Ovx, and TR-Intact groups. Sed-Intact-ND and TR-Intact-ND groups exhibited higher values of insulin sensitivity than the Sed-Intact group. Except for the TR-Intact group, sensitivity was greater in trained groups than in the Sed-Intact group. There was higher insulin sensitivity in the TR-Intact-ND group than in the Sed-Intact and Sed-Intact-ND groups (P < 0.05). In conclusion, ovariectomy and short-term RT alone induced no change on insulin action. Administration of nandrolone decanoate improved insulin action, mainly when it was associated with RT.
authors.affiliation: Health Sciences, Methodist University of Piracicaba, Piracicaba, SP.
authors.forename: Christiano Bertoldo
authors.initials: CB
authors.lastname: Urtado
authors.forename: Guilherme Borges
authors.initials: GB
authors.lastname: Pereira
authors.forename: Marilia Bertoldo
authors.initials: MB
authors.lastname: Urtado
authors.forename: Erica Blascovi
authors.initials: EB
authors.lastname: de Carvalho
authors.forename: Gerson Dos Santos
authors.initials: Gdos S
authors.lastname: Leite
authors.forename: Felipe Fedrizzi
authors.initials: FF
authors.lastname: Donatto
authors.forename: Claudio
authors.initials: C
authors.lastname: de Oliveira Assumpção
authors.forename: Richard Diego
authors.initials: RD
authors.lastname: Leite
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: da Silva
authors.forename: Marcelo Magalhães
authors.initials: MM
authors.lastname: de Sales
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.forename: Silvia Cristina Crepaldi
authors.initials: SC
authors.lastname: Alves
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes