title: The emerging role of PtdIns5P: another signalling phosphoinositide takes its place.
abstract: Of the seven phosphoinositides, PtdIns5P remains the most enigmatic. However, recent research has begun to elucidate its physiological functions. It is now clear that PtdIns5P is found in several distinct subcellular locations, and the identification of a number of PtdIns5P-binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully understood, the existence of multiple pathways for PtdIns5P regulation is consistent with this emerging versatility.
authors.affiliation: Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Grainger
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Tavelis
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Ryan
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Hinchliffe
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D018129:Phosphatidylinositol Phosphates; C113567:phosphatidylinositol 5-phosphate; D019869:Phosphatidylinositol 3-Kinases; C116930:Pikfyve protein, mouse; D010744:Phosphoric Monoester Hydrolases