title: [Effect of Cordyceps sinensis sporocarp on learning-memory in mice].
abstract: OBJECTIVE
  To study the effect of extracts of Cordyceps sinensis sporocarp on learning-memory in scopolamine treated mice and the possible mechanism.
  
  
  METHODS
  ICR mice were randomly divided into five groups: sham control, model, piracetam and CSE 0.5, 1 g/kg. Lotomotor activity was assessed. Morris water maze was used to evaluate the memory ability of mice 30 min later after ip scopolamine 1.0 mg/kg BW. Then acitivity of AchE was measured after behavioral test.
  
  
  RESULTS
  CSE had no influence on lotomotor activity. However, CSE 0.5, 1 g/kg both shortened escape latency and increased times of come-crossing platform in Morris water maze, meanwhile activity of AchE in the brain was decreased by CSE.
  
  
  CONCLUSIONS
  CSE can significantly improve the learning and memory impairment in mice induced by scopolamine, which may be correlated with the inhibition of activity of AchE.
authors.affiliation: Naval Medical Research Institute, Shanghai 200433, China. gongmeifang440@126.com
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Gong
authors.forename: Jiang-Ping
authors.initials: JP
authors.lastname: Xu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Chu
authors.forename: Jie
authors.initials: J
authors.lastname: Luan
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003071:Cognition; D032661:Cordyceps / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D011897:Random Allocation; D012601:Scopolamine / Q000008:administration & dosage
chemical_list: D004365:Drugs, Chinese Herbal; D018697:Nootropic Agents; D012601:Scopolamine; D000110:Acetylcholinesterase