title: Diversity within the pRb pathway: is there a code of conduct?
abstract: The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings.
authors.affiliation: Laboratory of Cancer Biology, Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Munro
authors.forename: S M
authors.initials: SM
authors.lastname: Carr
authors.forename: N B
authors.initials: NB
authors.lastname: La Thangue
mesh_terms: D000107:Acetylation; D017209:Apoptosis; D002453:Cell Cycle / Q000235:genetics; D049109:Cell Proliferation; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D016160:Retinoblastoma Protein / Q000378:metabolism*; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D016160:Retinoblastoma Protein