title: Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.
abstract: OBJECTIVE
  The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine.
  
  
  METHODS
  In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H(2) plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H(2) plus 98% oxygen. Group E inhaled 4% H(2) plus 96% oxygen.
  
  
  RESULTS
  The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74 ± 13 (mean ± SD) %, which was significantly higher than that in group A (48 ± 15%). Myocardial infarct size in group E (32 ± 10%), but not in group D (40 ± 9%) was smaller than that in group C (46 ± 6%).
  
  
  CONCLUSIONS
  Inhalation of 2% H(2) gas improves myocardial stunning, and inhalation of 4% but not 2% H(2) gas reduces myocardial infarct size in swine.
authors.affiliation: Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sakai
authors.forename: Sungsam
authors.initials: S
authors.lastname: Cho
authors.forename: Itsuko
authors.initials: I
authors.lastname: Shibata
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshitomi
authors.forename: Takuji
authors.initials: T
authors.lastname: Maekawa
authors.forename: Koji
authors.initials: K
authors.lastname: Sumikawa
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D005740:Gases; D006859:Hydrogen / Q000008:administration & dosage*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D017682:Myocardial Stunning / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D013552:Swine; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D005740:Gases; D006859:Hydrogen