title: Heterocyclic urea derivatives and methods of use thereof (WO2010142978).
abstract: A series of ureido derivatives incorporating a highly derivatized quinolone scaffold were prepared by a succession of original steps. The lead molecules of these compounds are the quinolone antibacterials of the nalidixic acid/ciprofloxacin type and they target, similar to these clinically used agents, the DNA gyrase/topoisomerase IV of pathogenic bacteria. These new quinolones are claimed to act as efficient antibacterials against a large number of drug-resistant bacteria such as Staphylococcus spp., Enterococcus spp., Streptococcus spp., Acinetobacter baumannii, Bacteroides bivius, Burkholderia spp., Chlamydia spp., Chlamydophila pneumoniae.
authors.affiliation: Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Andrea
authors.initials: A
authors.lastname: Scozzafava
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D007880:Legislation, Drug; D015394:Molecular Structure; D010330:Patents as Topic; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D014508:Urea