title: Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.
abstract: Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.
authors.affiliation: Clinical Research Group, Liverpool School of Tropical Medicine, United Kingdom.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Wall
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gordon
authors.forename: Samia
authors.initials: S
authors.lastname: Hussain
authors.forename: Upali R S
authors.initials: UR
authors.lastname: Goonetilleke
authors.forename: Jenna
authors.initials: J
authors.lastname: Gritzfeld
authors.forename: Matthew
authors.initials: M
authors.lastname: Scarborough
authors.forename: Aras
authors.initials: A
authors.lastname: Kadioglu
mesh_terms: D058491:Bacterial Load; D001426:Bacterial Proteins / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000382:microbiology; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid* / Q000401:mortality*; D009439:Neuraminidase / Q000134:cerebrospinal fluid; D013301:Streptolysins / Q000134:cerebrospinal fluid*
chemical_list: D001426:Bacterial Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D009439:Neuraminidase