title: Expression of matrix metalloproteinase-7 is an unfavorable prognostic factor in intrahepatic cholangiocarcinoma.
abstract: BACKGROUND
  Intrahepatic cholangiocarcinoma (IHCC) is a highly malignant neoplasm, but the prognostic factors of IHCC are not yet fully understood. The matrix metalloproteinases (MMPs) are known to be related to tumor viability. The aim of this study was to evaluate the prognostic significance of clinicopathological and immunohistochemical characteristics of resected IHCC.
  
  
  METHODS
  From 1996 to 2006, we surgically treated 35 patients with IHCC. Clinicopathological and immunohistochemical characteristics, including expression of MMPs, vascular endothelial growth factor, and epidermal growth factor receptor in the resected specimens, were investigated, and overall survival rates were evaluated with regard to the characteristics using univariate and multivariate analyses.
  
  
  RESULTS
  Univariate analysis revealed the significant prognostic factors to be preoperative serum CEA and CA19-9, intraoperative transfusion, tumor size, surgical margin, lymph node metastasis, invasion of portal and hepatic vein, intrahepatic metastasis, UICC stage, and expression of MMP-7. Subsequent multivariate analysis indicated that MMP-7 was an independent prognostic factor (hazard ratio (HR), 4.698; 95% confidence interval (CI), 0.057-0.866; P = 0.03) along with intrahepatic metastasis (HR, 5.694; 95% CI, 0.029-0.706; P = 0.017).
  
  
  CONCLUSIONS
  MMP-7 expression is associated with a poor prognosis in patients with resected IHCC.
authors.affiliation: Department of Surgery I, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan. teij03@oita-u.ac.jp
authors.forename: Teijiro
authors.initials: T
authors.lastname: Hirashita
authors.forename: Yukio
authors.initials: Y
authors.lastname: Iwashita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Yoko
authors.initials: Y
authors.lastname: Komori
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yada
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitano
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D018281:Cholangiocarcinoma / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011169:Portal Vein / Q000473:pathology; D011379:Prognosis; D047368:Tumor Burden
chemical_list: D020783:Matrix Metalloproteinase 7