title: [Study on the expression and potential effect of PD-L1mRNA and PD-L2mRNA in oral lichen planus].
abstract: OBJECTIVE
  To study the expression of PD-L1 and PD-L2mRNA in oral lichen planus(OLP) patients' peripheral blood and focal mucosa, and the different expression of target molecules in gene level in different clinical and pathological OLP groups.
  
  
  METHODS
  The expression of PD-L1 and PD-L2 mRNA in OLP patients, which included 35 reticular and 25 atrophic-erosive OLP patients, 38 cases without dysplasia and 22 cases with dysplasia, was examined by real-time PCR. Peripheral blood and mucosa from 10 volunteers were used as control. All the results were analysed with Wilcoxon test by SAS.6.12 software package.
  
  
  RESULTS
  The expression of PD-L2mRAN, but not PD-L1, was significantly higher in oral mucosa of OLP patients (P<0.01), while decreased in OLP patients' peripheral blood (P=0.0415). The gene expression of PD-L2 differed between different clinical types, and had highly significant correlation between the OLP patients' focal mucosa and peripheral blood(r=0.6976, P<0.0001).
  
  
  CONCLUSIONS
  PD-L2 may have some potential effect on the pathogenesis of OLP at systemic and local level.
authors.affiliation: Department of Oral Medicine, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratary of Stomatology, Shanghai 200011, China. dgh-09@163.com
authors.forename: Guan-huan
authors.initials: GH
authors.lastname: DU
authors.forename: Xiao-peng
authors.initials: XP
authors.lastname: Qin
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Yong-mei
authors.initials: YM
authors.lastname: Zhou
authors.forename: Xue-min
authors.initials: XM
authors.lastname: Shen
authors.forename: Guo-yao
authors.initials: GY
authors.lastname: Tang
mesh_terms: D006801:Humans; D017676:Lichen Planus, Oral; D009061:Mouth Mucosa; D012333:RNA, Messenger
chemical_list: D012333:RNA, Messenger