title: Outer membrane protein A and OprF: versatile roles in Gram-negative bacterial infections.
abstract: Outer membrane protein A (OmpA) is an abundant protein of Escherichia coli and other enterobacteria and has a multitude of functions. Although the structural features and porin function of OmpA have been well studied, its role in the pathogenesis of various bacterial infections has emerged only during the last decade. The four extracellular loops of OmpA interact with a variety of host tissues for adhesion to and invasion of the cell and for evasion of host-defense mechanisms when inside the cell. This review describes how various regions present in the extracellular loops of OmpA contribute to the pathogenesis of neonatal meningitis induced by E. coli K1 and to many other functions. In addition, the function of OmpA-like proteins, such as OprF of Pseudomonas aeruginosa, is discussed.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, CA, USA.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Krishnan
authors.forename: Nemani V
authors.initials: NV
authors.lastname: Prasadarao
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D016905:Gram-Negative Bacterial Infections / Q000378:metabolism*; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C547605:OprF protein, Pseudomonas aeruginosa; C078167:OMPA outer membrane proteins