title: Perinatal hypoxic-ischemic brain injury affects the glutamatergic signal transduction coupled with neuronal ADP-ribosyl cyclase activity.
abstract: Agonists of glutamate ionotropic (NMDA) and metabotropic receptors (mGluRI and mGluRIII) had the regulatory effect on ADP-ribosyl cyclase/CD38 activity in cerebellar granular cells of newborn rats. Perinatal hypoxic-ischemic brain injury was followed by dysregulation of this mechanism.
authors.affiliation: Department of Biochemistry, Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk, Russia. allasalmina@mail.ru
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.forename: O S
authors.initials: OS
authors.lastname: Okuneva
authors.forename: S V
authors.initials: SV
authors.lastname: Mikhutkina
authors.forename: N A
authors.initials: NA
authors.lastname: Malinovskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Morgun
authors.forename: L D
authors.initials: LD
authors.lastname: Zykova
authors.forename: G V
authors.initials: GV
authors.lastname: Yudin
authors.forename: D V
authors.initials: DV
authors.lastname: Laletin
authors.forename: M A
authors.initials: MA
authors.lastname: Fursov
authors.forename: O V
authors.initials: OV
authors.lastname: Frolova
authors.forename: G A
authors.initials: GA
authors.lastname: Tagaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Bolshakova
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism*; D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism*; D005260:Female; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D051381:Rats; D058468:Receptors, Ionotropic Glutamate / Q000819:agonists*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D015398:Signal Transduction
chemical_list: D018690:Excitatory Amino Acid Agonists; D008562:Membrane Glycoproteins; D058468:Receptors, Ionotropic Glutamate; D018094:Receptors, Metabotropic Glutamate; D016202:N-Methylaspartate; D036541:ADP-ribosyl Cyclase; C498156:Cd38 protein, rat; D051997:ADP-ribosyl Cyclase 1