title: Effect of glucocorticoid receptor blockade on analgesic effect of corticotropin-releasing factor.
abstract: The role of glucocorticoid receptors in the analgesic effect of corticotropin-releasing factor in rats was studied after glucocorticoid receptor blockade with antagonist RU 38486. Glucocorticoid hormones can potentiate the analgesic effect of corticotropin-releasing factor or modulate the mechanisms of this effect, which depends on the type of painful stimulus.
authors.affiliation: Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. yarni60@mail.ru
authors.forename: N I
authors.initials: NI
authors.lastname: Yarushkina
authors.forename: T R
authors.initials: TR
authors.lastname: Bagaeva
authors.forename: L P
authors.initials: LP
authors.lastname: Filaretova
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D003345:Corticosterone; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D015735:Mifepristone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors*
chemical_list: D000700:Analgesics; D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone