title: The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.
abstract: The breast cancer susceptibility genes 1 (BRCA1) and 2 (BRCA2) are cellular proteins involved in DNA repair. They are normally expressed in the breast, ovaries, prostate, and other tissues. Their germline mutation is the cause of hereditary breast-ovarian cancer syndromes. BRCA mutation carriers are also susceptible to other cancers, notably prostate cancer. In this article, we review the role of BRCA genes in the pathogenesis and clinical course of prostate cancer. We also discuss the molecular mechanisms of action and the therapeutic implications of BRCA germline mutations.
authors.affiliation: Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, Nevada 89135, USA.
authors.forename: Srinath
authors.initials: S
authors.lastname: Sundararajan
authors.forename: Aisha
authors.initials: A
authors.lastname: Ahmed
authors.forename: Oscar B
authors.initials: OB
authors.lastname: Goodman
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D002453:Cell Cycle; D049109:Cell Proliferation; D004249:DNA Damage; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D004273:DNA, Neoplasm