title: Metastatic hepatocellular carcinoma to the skin staining positive with HMB-45.
abstract: Hepatocellular carcinoma (HCC) is uncommonly observed as a cutaneous metastasis. We report a 76-year-old man with metastatic HCC to the skin of the nasal ala, diagnosed antecedent to the primary tumor. HCC was confirmed by positive immunostaining with Hep Par 1 in tissue from the metastasis and from a needle biopsy of the primary lesion. In addition, tumor cells from both the metastasis and liver stained positive with HMB-45. To our knowledge, HMB-45 positive staining has not been reported in either primary or metastatic HCC.
authors.affiliation: Bernhardt Laboratories, Aurora Diagnostics/DERMDX Division, Jacksonville, FL 32216, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Gross
authors.forename: Charles
authors.initials: C
authors.lastname: Perniciaro
authors.forename: David J
authors.initials: DJ
authors.lastname: Gross
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Barksdale
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D008297:Male; D058950:Melanoma-Specific Antigens / Q000378:metabolism*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary / Q000628:therapy; D016896:Treatment Outcome; D058951:gp100 Melanoma Antigen
chemical_list: D014408:Biomarkers, Tumor; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D058951:gp100 Melanoma Antigen