title: Animal models for microbicide studies.
abstract: There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.
authors.affiliation: Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA. rveazey@tulane.edu
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Veazey
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Shattock
authors.forename: Per Johan
authors.initials: PJ
authors.lastname: Klasse
authors.forename: John P
authors.initials: JP
authors.lastname: Moore
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D015497:HIV-1 / Q000187:drug effects*; D008253:Macaca mulatta; D051379:Mice; D011817:Rabbits; D051381:Rats
chemical_list: D000891:Anti-Infective Agents, Local; D044966:Anti-Retroviral Agents