title: Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis.
abstract: The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with inflammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.
authors.affiliation: D. O. Ott Institute of Obstetrics and Gynecology, North Western Division of Russian Academy of Medical Sciences, St. Petersburg, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Ostankova
authors.forename: Ya S
authors.initials: YS
authors.lastname: Klimovskaya
authors.forename: O A
authors.initials: OA
authors.lastname: Gorskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Kolobov
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoi
authors.forename: S A
authors.initials: SA
authors.lastname: Selkov
authors.forename: D I
authors.initials: DI
authors.lastname: Sokolov
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications; D012333:RNA, Messenger; D019700:Thrombospondin 1 / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012333:RNA, Messenger; D019700:Thrombospondin 1