title: Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network.
abstract: The concomitant production of IL-17A and IL-9, both Th17 cytokines, has not been compared in MS patients. We show that IL-17A but not IL-9 expression by CD3(+) cells was increased during a MS relapse. Co-expression of IL-17A and IL-9 was marginal. In addition to Th1 and Th2 cytokines, IL-17A, IL-6 and IL-23p19 were down-regulated by ivMP, but Foxp3 was not, while an increase in IL-10, TGF-β1 and IL-27p28 mRNA was observed. This change in the Th17, Treg and IL-10 balance could be an additional mechanism by which corticosteroids shorten the duration of a MS relapse and promote recovery.
authors.affiliation: Unité de Neurochimie, Institute of Neuroscience, Avenue Mounier, 53 (BP 53.02), Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Muls
authors.forename: Karima
authors.initials: K
authors.lastname: Jnaoui
authors.forename: Hong Anh
authors.initials: HA
authors.lastname: Dang
authors.forename: Antony
authors.initials: A
authors.lastname: Wauters
authors.forename: Jacques
authors.initials: J
authors.lastname: Van Snick
authors.forename: Christian Jean-Marie
authors.initials: CJ
authors.lastname: Sindic
authors.forename: Vincent
authors.initials: V
authors.lastname: van Pesch
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000704:Analysis of Variance; D001773:Blood Cells / Q000187:drug effects*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003711:Demyelinating Diseases / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D016906:Interleukin-9 / Q000235:genetics / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000473:pathology*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones; D016207:Cytokines; D020381:Interleukin-17; D016906:Interleukin-9