title: A stereoselective hydroamination transform to access polysubstituted indolizidines.
abstract: Stereoselective, intramolecular, formal hydroamination of dienamines via directed hydroboration is reported. Four stereocenters are set in the process. Natural and unnatural indolizidine alkaloids can be synthesized from simple unsaturated amines using the title process.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Pronin
authors.forename: M Greg
authors.initials: MG
authors.lastname: Tabor
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Jansen
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Shenvi
mesh_terms: D000586:Amination; D018360:Crystallography, X-Ray; D054836:Indolizidines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D054836:Indolizidines; D011108:Polymers