title: Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life.
abstract: BACKGROUND
  Due to its long-term persistence in the environment and its ability to cross the placental barrier, prenatal p,p'-dichlorodiphenyldichloroethene (DDE) exposure continues to be a public health concern. This study aimed to evaluate the association between prenatal DDE exposure and child growth, at birth and during the first year of life.
  
  
  METHODS
  253 pregnant women were recruited between January 2001 and June 2005 in a prospective cohort in Morelos, Mexico. Serum levels of DDE were measured during each trimester of pregnancy by gas chromatography with an electron capture detector. Using the generalized mixed-effects models, the association between DDE and child growth parameters (weight-for-age, length-for-age, weight-for-length, BMI-for-age and head circumference-for-age Z-scores) from birth to 1 year of age was assessed. Maternal dietary intake was considered as covariable among others.
  
  
  RESULTS
  DDE levels were 6.3±2.8 ng/mL (first trimester), 6.6±2.9 ng/mL (second trimester), and 7.6±2.9 ng/mL (third trimester). After adjusting for potential confounder variables, no significant associations were observed with prenatal DDE exposure and each of the selected parameters.
  
  
  CONCLUSIONS
  Our results show no evidence of an association between prenatal DDE exposure and child growth during the first year of life.
authors.affiliation: Department of Preventive Medicine, Mount Sinai School of Medicine, International Training and Research in Environmental and Occupational Health Program, 17 E 102nd Street, CAM Building, 3 West, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA. sgarced@gmail.com
authors.forename: Sheyla
authors.initials: S
authors.lastname: Garced
authors.forename: Luisa
authors.initials: L
authors.lastname: Torres-Sánchez
authors.forename: Mariano E
authors.initials: ME
authors.lastname: Cebrián
authors.forename: Luz
authors.initials: L
authors.lastname: Claudio
authors.forename: Lizbeth
authors.initials: L
authors.lastname: López-Carrillo
mesh_terms: D000328:Adult; D049628:Body Size / Q000187:drug effects*; D002849:Chromatography, Gas; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood / Q000633:toxicity*; D005260:Female; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007306:Insecticides / Q000097:blood / Q000633:toxicity*; D016014:Linear Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008800:Mexico; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D011446:Prospective Studies
chemical_list: D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene