title: aPTT prolongation and skin eruption possibly associated with lamotrigine monotherapy in a paediatric patient.
abstract: We report the case of a six-year-old female with childhood absence epilepsy who developed combined aPTT prolongation, not corrected by normal plasma, and atypical skin eruption six months after initiating lamotrigine treatment with dose increment. Two weeks after lamotrigine withdrawal, the skin eruption disappeared and aPTT normalised. To our knowledge, this is the first report of aPTT prolongation possibly due to factor inhibitors associated with lamotrigine monotherapy.
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea. polo96@daum.net
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Yeom
authors.forename: Ji Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Seo
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Park
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Lim
authors.forename: Chan-Hoo
authors.initials: CH
authors.lastname: Park
authors.forename: Hyang Ok
authors.initials: HO
authors.lastname: Woo
authors.forename: Hee-Shang
authors.initials: HS
authors.lastname: Youn
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001774:Blood Chemical Analysis; D001779:Blood Coagulation Factors / Q000378:metabolism; D002648:Child; D003875:Drug Eruptions / Q000473:pathology*; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D010314:Partial Thromboplastin Time; D012867:Skin / Q000473:pathology; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D001779:Blood Coagulation Factors; D014227:Triazines; D000077213:Lamotrigine