title: Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study.
abstract: OBJECTIVE
  Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers.
  
  
  METHODS
  This is a retrospective cohort study in a large tertiary institution in Singapore. The sample consists of women with endometrial and epithelial ovarian cancers followed up over a period of 10 years from 2000 to 2009. The epidemiological and clinical factors include age at diagnosis, histology types, grade and stage of disease.
  
  
  RESULTS
  A total of 75 patients with synchronous ovarian and endometrial cancers were identified. However, only 46 patients met the inclusion criteria. The median follow-up was 74 months. The incidence rate for synchronous cancer is 8.7% of all epithelial ovarian cancers and 4.9% of all endometrial cancers diagnosed over this time frame. Mean age at diagnosis was 47.3 years old. The most common presenting symptom was abnormal uterine bleeding (36.9%) and 73.9% had endometrioid histology for both endometrial and ovarian cancers. The majority of the women (78%) presented were at early stages of 1 and 2. There were 6 (13.6%) cases of recurrence and the 5 year cumulative survival rate was at 84%.
  
  
  CONCLUSIONS
  In our cohort, we found that majority of women afflicted with synchronous cancer of the endometrium and ovary were younger at age of diagnosis, had early stage of cancer and good survival.
authors.affiliation: Department of Gynaecological Oncology, KK Women's & Children's Hospital, Singapore.
authors.forename: Yong Kuei
authors.initials: YK
authors.lastname: Lim
authors.forename: Rama
authors.initials: R
authors.lastname: Padma
authors.forename: Lilian
authors.initials: L
authors.lastname: Foo
authors.forename: Yin Nin
authors.initials: YN
authors.lastname: Chia
authors.forename: Philip
authors.initials: P
authors.lastname: Yam
authors.forename: John
authors.initials: J
authors.lastname: Chia
authors.forename: Hs
authors.initials: H
authors.lastname: Khoo-Tan
authors.forename: Swee Peng
authors.initials: SP
authors.lastname: Yap
authors.forename: Richard
authors.initials: R
authors.lastname: Yeo