title: Anti-hyperlipidemic constituents from the bark of Shorea roxburghii.
abstract: The methanol extract from the bark of Shorea roxburghii (Dipterocarpaceae, "Phayom" in Thai) was found to suppress plasma triglyceride elevation in olive oil-treated mice, and also to inhibit pancreatic lipase activity (IC(50) = 31.6 μg/ml). From the extract, two new 3-acetyl-4-phenyl-3,4-dihydroisocoumarins, phayomphenols A(1) (1) and A(2) (2) were isolated, together with 22 known compounds. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic evidence, including X-ray crystallographic analysis. Among the isolates, several oligostilbenoids, including (-)-hopeaphenol (3) and (+)-isohopeaphenol (4), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg p.o. and pancreatic lipase inhibitory activity (IC(50) = 32.9 and 26.5 μM, respectively).
authors.affiliation: Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Saowanee
authors.initials: S
authors.lastname: Chaipech
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamao
authors.forename: Yohei
authors.initials: Y
authors.lastname: Umeda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.forename: Haruka
authors.initials: H
authors.lastname: Tamura
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Yutana
authors.initials: Y
authors.lastname: Pongpiriyadacha
authors.forename: Takao
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
mesh_terms: D000818:Animals; D053958:Dipterocarpaceae / Q000737:chemistry*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy; D008049:Lipase / Q000378:metabolism; D008297:Male; D051379:Mice; D000069463:Olive Oil; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use; D010938:Plant Oils / Q000627:therapeutic use
chemical_list: D000069463:Olive Oil; D010936:Plant Extracts; D010938:Plant Oils; D008049:Lipase