title: Gadobenate dimeglumine-enhanced liver magnetic resonance imaging:  value of hepatobiliary phase for the detection of focal liver lesions.
abstract: OBJECTIVE
  The objective of the study was to determine the value of addition of hepatobiliary phase to dynamic gadobenate dimeglumine (Gd-BOPTA)-enhanced imaging for the detection of focal liver lesions (nodules with diameter ≤3.0 cm).
  
  
  METHODS
  Routine nonenhanced magnetic resonance images were obtained in 25 patients with focal liver lesions suggested by ultrasonography and/or computed tomography.T1-weighted dynamic gradient-echo images were acquired immediately and 100 minutes after bolus injection of Gd-BOPTA. The number of the lesions detected by T1-weighted imaging, T2-weighted imaging, diffusion-weighted imaging, dynamic contrast-enhanced, and delayed hepatobiliary-phase imaging was counted, respectively. Contrast-to-noise ratios were measured for all the sequences including delayed hepatobiliary-phase imaging. The signal intensity and morphologic features of liver parenchyma and lesions were recorded and analyzed.
  
  
  RESULTS
  There were 7 patients with hepatocellular carcinomas, 6 with hemangiomas, 7 with metastases, and 5 with cholangiocarcinomas. The delayed hepatobiliary-phase imaging showed a homogeneous enhancement of liver parenchyma and distinctive enhancement features of focal liver lesions. The delayed hepatobiliary-phase imaging was better than diffusion-weighted imaging for the detection of focal liver lesions (P < 0.05).
  
  
  CONCLUSIONS
  The addition of hepatobiliary-phase imaging to Gd-BOPTA-enhanced dynamic imaging increased the sensitivity and accuracy for the detection of focal hepatic lesions.
authors.affiliation: Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Fu
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
authors.forename: Chi-Shing
authors.initials: CS
authors.lastname: Zee
authors.forename: Han-Feng
authors.initials: HF
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Ru-Gang
authors.initials: RG
authors.lastname: Duan
authors.forename: Nan-Lin
authors.initials: NL
authors.lastname: Zeng
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D049448:Cholangiopancreatography, Magnetic Resonance; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006391:Hemangioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine