title: Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
abstract: Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.
authors.affiliation: PNG Institute of Medical Research, Goroka, Papua New Guinea.
authors.forename: Inoni
authors.initials: I
authors.lastname: Betuela
authors.forename: Quique
authors.initials: Q
authors.lastname: Bassat
authors.forename: Benson
authors.initials: B
authors.lastname: Kiniboro
authors.forename: Leanne J
authors.initials: LJ
authors.lastname: Robinson
authors.forename: Anna
authors.initials: A
authors.lastname: Rosanas-Urgell
authors.forename: Danielle
authors.initials: D
authors.lastname: Stanisic
authors.forename: Peter M
authors.initials: PM
authors.lastname: Siba
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Alonso
authors.forename: Ivo
authors.initials: I
authors.lastname: Mueller
mesh_terms: D000375:Aging / Q000502:physiology; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D037621:Artemisinins / Q000627:therapeutic use; D000077332:Artesunate; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D016780:Malaria, Vivax / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D009512:New Guinea; D011319:Primaquine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D006454:Hemoglobins; D000077332:Artesunate; D002738:Chloroquine; D011319:Primaquine