title: Rapid access to conformational analogues of (+)-peloruside A.
abstract: An efficient synthetic strategy for rapid access to analogues of peloruside A has been demonstrated. The synthetic route was highlighted by a simple esterification-based fragment coupling and a late stage ring-closing metathesis reaction. This convergent route has provided access to rationally designed analogues inspired by the solution conformational preferences of peloruside A.
authors.affiliation: Department of Chemistry and Biochemistry and the Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, USA.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhao
authors.forename: Richard E
authors.initials: RE
authors.lastname: Taylor
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry; D008968:Molecular Conformation; D013997:Time Factors
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D018942:Macrolides; C414085:peloruside A; C547698:peloruside B