title: Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy.
abstract: Corticobasal degeneration and Parkinson's disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and a-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and a-synucleinopathies might share common pathogenic mechanisms.
authors.affiliation: Department of Neurology, Nambour General Hospital, QLD, Australia. tominmooney@yahoo.com
authors.forename: Tomin
authors.initials: T
authors.lastname: Mooney
authors.forename: Anthony
authors.initials: A
authors.lastname: Tampiyappa
authors.forename: Thomas
authors.initials: T
authors.lastname: Robertson
authors.forename: Rohan
authors.initials: R
authors.lastname: Grimley
authors.forename: Chris
authors.initials: C
authors.lastname: Burke
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ng
authors.forename: Peter
authors.initials: P
authors.lastname: Patrikios
mesh_terms: D001479:Basal Ganglia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D008297:Male; D008543:Melanins / Q000378:metabolism; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications / Q000473:pathology*; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000150:complications; D038203:alpha-Crystallin B Chain / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D008543:Melanins; D038203:alpha-Crystallin B Chain; D051844:alpha-Synuclein; C014121:neuromelanin; D016875:tau Proteins