title: Reconstruction of multiple gastric electrical wave fronts using potential based inverse methods.
abstract: The ability to reconstruct gastric electrical activity (termed slow waves) non-invasively from potential field measurements made on the torso surface would be a useful tool to aid in the clinical diagnosis of a number of gastric disorders. This is mathematically akin to the inverse problem of electrocardiography. To investigate this problem, an anatomically realistic torso model and an electrical stomach model were used to simulate potentials on the stomach and skin surfaces arising from normal gastric electrical activity. Gaussian noise was added to the torso potentials to represent experimental signal noise. The stomach potentials, activation profiles and gastric slow wave velocities were inversely reconstructed from the torso potentials, using the Tikhonov-Greensite inverse method with regularisation determined using an L-curve method. The inverse solutions were then compared with the known input solutions. The reconstructed solutions were able to represent the presence of multiple propagating wave fronts, determine average activation times to within 5 s and average velocities to within 1 mm/s. When more virtual body surface electrodes were used in the inverse calculations, the accuracy of the reconstructed activity improved.
authors.affiliation: Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand. juliana.kim@auckland.ac.nz
authors.forename: J H K
authors.initials: JH
authors.lastname: Kim
authors.forename: A J
authors.initials: AJ
authors.lastname: Pullan
authors.forename: L K
authors.initials: LK
authors.lastname: Cheng
mesh_terms: D003198:Computer Simulation; D004576:Electromyography / Q000379:methods*; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009130:Muscle, Smooth / Q000502:physiology*; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D013270:Stomach / Q000502:physiology*