title: Antiparasitic antioxidant phenylpropanoids and iridoid glycosides from Tecoma mollis.
abstract: A radical scavenging guided phytochemical study on the stem bark of Tecoma mollis afforded seven active phenylpropanoid glycosides (1-7), including a new one (4), and one iridoid (8). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (1-7) displayed promising antioxidant activity (DPPH assay) in relation to ascorbic acid (positive control). The antimicrobial activity for compounds (1-8) was evaluated against five bacterial and five fungal strains. The isolated compounds exhibited nonselective weak to moderate antimicrobial activity. The highest antileishmanial activity against Leishmania donovani was observed for compound (7) with an IC₅₀ value of 6.71 μg/ml, using pentamidine and amphotericin B as drug controls. Compound (5) exhibited moderate antimalarial activity (45% inhibition) against chloroquine sensitive (D6) clones of Plasmodium falciparum.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt. Waelabdelmageed@yahoo.com
authors.forename: Wael M
authors.initials: WM
authors.lastname: Abdel-Mageed
authors.forename: Enaam Y
authors.initials: EY
authors.lastname: Backheet
authors.forename: Azza A
authors.initials: AA
authors.lastname: Khalifa
authors.forename: Zedan Z
authors.initials: ZZ
authors.lastname: Ibraheim
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D029402:Bignoniaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D057889:Iridoid Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D010963:Plasmodium falciparum / Q000187:drug effects; D020005:Propanols / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; D000975:Antioxidants; D000981:Antiprotozoal Agents; D001713:Biphenyl Compounds; D057889:Iridoid Glycosides; D010851:Picrates; D010936:Plant Extracts; D020005:Propanols; D014344:Trypanocidal Agents; C004931:1,1-diphenyl-2-picrylhydrazyl