title: Effect of epithermal neutrons on viability of glioblastoma tumor cells in vitro.
abstract: We studied in vitro effect of epithermal neutrons in various doses on viability of glioblastoma U87 tumor cells. Increasing the dose from 1.9 to 4.1 Sv promoted cell death. Cytofluorimetric analysis revealed no activation of apoptosis in the irradiated cells, which attested to necrotic death of the tumor cells exposed to epithermal neutron radiation.
authors.affiliation: Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. mostovichl@gmail.ru
authors.forename: L A
authors.initials: LA
authors.lastname: Mostovich
authors.forename: N V
authors.initials: NV
authors.lastname: Gubanova
authors.forename: O S
authors.initials: OS
authors.lastname: Kutsenko
authors.forename: V I
authors.initials: VI
authors.lastname: Aleinik
authors.forename: A S
authors.initials: AS
authors.lastname: Kuznetsov
authors.forename: A N
authors.initials: AN
authors.lastname: Makarov
authors.forename: I N
authors.initials: IN
authors.lastname: Sorokin
authors.forename: S Yu
authors.initials: SY
authors.lastname: Taskaev
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomnyashchikh
authors.forename: E V
authors.initials: EV
authors.lastname: Grigor'eva
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor / Q000528:radiation effects; D048430:Cell Shape / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects*; D005347:Fibroblasts / Q000528:radiation effects; D005909:Glioblastoma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D051379:Mice; D009502:Neutrons