title: [A study of patients with Clostridium difficile infection hospitalized at Brno Clinic of Infectious Diseases in 2007-2010].
abstract: BACKGROUND
  To describe a set of patients hospitalized at the Clinic of Infectious Diseases of the University Hospital Brno with Clostridium difficile infection (CDI), to interpret clinical and epidemiological data, and to determine the risk factors for the disease and its complications.
  
  
  METHODS
  A retrospective study of 284 patients with confirmed diagnosis of Clostridium difficile infection hospitalized between 1 January 2007 and 31 December 2010. Epidemiological, clinical and laboratory data were collected from their clinical documentation.
  
  
  RESULTS
  Of the 284 patients with a mean age of 73.2 years, 38.0 % were men. Risk factors for developing CDI include the use of antibiotics in the previous 8 weeks (89.1 % of patients), age over 65 years (77.6 %), hospitalization in the previous 4 weeks (65.5 %), and the use of proton pump inhibitors (41.9 %). Recurrence was noted in 89 (31.3 %) cases. Sixty-six (23.2 %) patients required intensive care and 50 (14.6 %) patients died during their hospitalization. Isolates of C. difficile from the stool of 4 patients were sent for ribotyping and identified as ribotype 176.
  
  
  CONCLUSIONS
  The CDI rates at the clinic KICH have increased in the recent years. The rise is consistent with the global trends. The study confirmed the disease risk factors reported in the literature. The disease is associated with a high percentage of relapses and complications.
authors.affiliation: Clinic of Infectious Diseases of the University Hospital Brno, Masaryk University Brno, Czech Republic. lvojtilova@fnbrno.cz
authors.forename: Lenka
authors.initials: L
authors.lastname: Vojtilová
authors.forename: Michaela
authors.initials: M
authors.lastname: Freibergerová
authors.forename: Jana
authors.initials: J
authors.lastname: Juránková
authors.forename: Petr
authors.initials: P
authors.lastname: Husa
authors.forename: Pavel
authors.initials: P
authors.lastname: Polák
authors.forename: Hana
authors.initials: H
authors.lastname: Kocourková
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016360:Clostridioides difficile; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents