title: Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
authors.affiliation: Rigel, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, USA. rsingh@rigel.com
authors.forename: Rajinder
authors.initials: R
authors.lastname: Singh
authors.forename: Esteban S
authors.initials: ES
authors.lastname: Masuda
authors.forename: Donald G
authors.initials: DG
authors.lastname: Payan
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D051746:ZAP-70 Protein-Tyrosine Kinase