title: Studies toward the synthesis of spirolide C: exploration into the formation of the 23-membered all-carbon macrocyclic framework.
abstract: The synthesis of two complex subunits en route to spirolide C is described. A key alkyllithium addition to an aldehyde joins the fragments, which are advanced in order to investigate a ring-closing metathesis to form the 23-membered all-carbon macrocyclic framework.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Stivala
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Gu
authors.forename: Lindsay L
authors.initials: LL
authors.lastname: Smith
authors.forename: Armen
authors.initials: A
authors.lastname: Zakarian
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D000447:Aldehydes; D013141:Spiro Compounds; C429216:spirolide C