title: Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells.
abstract: Pancreatic acinar cells exhibit a remarkable polarization of Ca2+ release and Ca2+ influx mechanisms. In the present brief review, we discuss the localization of channels responsible for Ca2+ release [mainly IP3 (inositol 1,4,5-trisphosphate) receptors] and proteins responsible for SOCE (store-operated Ca2+ entry). We also place these Ca2+-transporting mechanisms on the map of cellular organelles in pancreatic acinar cells, and discuss the physiological implications of the cellular geography of Ca2+ signalling. Finally, we highlight some unresolved questions stemming from recent observations of co-localization and co-immunoprecipitation of IP3 receptors with Orai channels in the apical (secretory) region of pancreatic acinar cells.
authors.affiliation: Department of Cellular and Molecular Physiology, the Physiological Laboratory, Institute of Translational Medicine, the University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors.forename: Hayley
authors.initials: H
authors.lastname: Dingsdale
authors.forename: Svetlana
authors.initials: S
authors.lastname: Voronina
authors.forename: Lee
authors.initials: L
authors.lastname: Haynes
authors.forename: Alexei
authors.initials: A
authors.lastname: Tepikin
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Lur
mesh_terms: D061354:Acinar Cells / Q000378:metabolism; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D016764:Cell Polarity; D004847:Epithelial Cells / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D000071740:ORAI1 Protein; D015388:Organelles / Q000378:metabolism; D010179:Pancreas / Q000166:cytology; D000071737:Stromal Interaction Molecule 1
chemical_list: D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008562:Membrane Glycoproteins; D000071740:ORAI1 Protein; C520430:Orai1 protein, mouse; C100757:Stim1 protein, mouse; D000071737:Stromal Interaction Molecule 1