title: A new lupane triterpene from Tetracera scandens L., xanthine oxidase inhibitor.
abstract: From the MeOH extract of the stem of Tetracera scandens L., a new nor-lupane triterpene, 28-O-β-D-glucopyranosyl ester of platanic acid (1), has been isolated together with six known compounds. Their structures were elucidated on the basis of spectroscopic data. Compounds 1-6 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compound 4 showed more potent inhibitory activity with an IC(50) value of 1.9 µM than that of a positive control allopurinol (IC(50) 2.5 µM).
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Vietnam. nttmai@hcmus.edu.vn
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
mesh_terms: D045466:Dilleniaceae / Q000737:chemistry* / Q000201:enzymology; D014315:Triterpenes / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D014315:Triterpenes; C087107:platanic acid; D014969:Xanthine Oxidase