title: [High mortality in patients with idiopathic pulmonary fibrosis on Dutch lung transplant waiting list].
abstract: OBJECTIVE
  To describe patients diagnosed with idiopathic pulmonary fibrosis (IPF) registered for lung transplantation and to evaluate the current referral guidelines for lung transplantation in the Netherlands.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  All patients diagnosed with interstitial lung disease and registered for lung transplantation from September 1989-June 2010 were included in this study. Patients who had been diagnosed with IPF according to the American Thoracic Society-European Respiratory Society criteria were included. Clinical data of these patients at the time of screening for lung transplantation and survival data were collected.
  
  
  RESULTS
  In total, 289 patients with IPF were registered for lung transplantation. After a first waiting list. During the waiting period, 30 patients (33%) died, 7 were taken off the list due to newly developed comorbidity and excessive physical deterioration, 51 underwent transplantation and 2 were still on the waiting list at the time of study closure. At the time of screening, the mean FVC% predicted of these patients was 51% (SD: 19.0) and the mean diffusing capacity was 27% of predicted (SD: 9.3).
  
  
  CONCLUSIONS
  One-third of the IPF patients on the waiting list died before donor lungs became available. The mean diffusing capacity of 27% of predicted at the time of screening was considerably lower than advised in the international guidelines for placement on the waiting list. This study, therefore, shows that the timing of screening IPF patients for lung transplantation can be improved in the Netherlands.
authors.affiliation: St. Antonius Ziekenhuis, Centrum voor Interstitiële Longziekten, afd. Longziekten, Nieuwegein, the Netherlands.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: ten Klooster
authors.forename: Coline H M
authors.initials: CH
authors.lastname: van Moorsel
authors.forename: Peter Th W
authors.initials: PT
authors.lastname: van Hal
authors.forename: Bernt
authors.initials: B
authors.lastname: van den Blink
authors.forename: George D
authors.initials: GD
authors.lastname: Nossent
authors.forename: Erik A M
authors.initials: EA
authors.lastname: Verschuuren
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Kwakkel-van Erp
authors.forename: Ed A
authors.initials: EA
authors.lastname: van de Graaf
authors.forename: Diana A
authors.initials: DA
authors.lastname: van Kessel
authors.forename: Jan C
authors.initials: JC
authors.lastname: Grutters
mesh_terms: D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000401:mortality* / Q000628:therapy; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009426:Netherlands; D010102:Oxygen Inhalation Therapy; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D014109:Total Lung Capacity / Q000502:physiology; D014850:Waiting Lists / Q000401:mortality*