title: Effects of tandem shock waves combined with photosan and cytostatics on the growth of tumours.
abstract: Shock waves, pressure waves manifested           as a sharp increase in positive pressure followed by a           decrease and the negative part of the wave, are not           only used to treat concrements in medicine. Recently,           research has been focused on the possibility of their           use for damaging the tumour tissue. In contrast to           concrements, which are different from the surrounding           tissue by their acoustic impedance, the tumour           tissue has the same acoustic impedance as the surrounding           soft tissue. Therefore, we have developed a           new source of shock waves, which is based on the           principle of multichannel discharge. This new source           generates two successive shock waves (tandem shock           waves). The first shock creates acoustic non-homogeneity           and cavitations in the tissue, and the second           shock is damped in it. In this work we demonstrated           the effect of tandem shock waves on the muscle tissue           in depth. The damage is shown on the images from           the magnetic resonance imaging and histological sections.           In the further part of the experiment, we investigated           the in vivo effects of tandem shock waves in           combination with Photosan and cisplatin on the tumour           tissue. The application of tandem shock waves           resulted in the inhibition of tumour growth, compared           with controls, in both parts of the experiment.           The largest inhibition effect was observed in the           groups of tandem shock waves combined with Photosan           and in the second part with cisplatin.
authors.affiliation: Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Beneš
authors.forename: P
authors.initials: P
authors.lastname: Poučková
authors.forename: J
authors.initials: J
authors.lastname: Zeman
authors.forename: M
authors.initials: M
authors.lastname: Zadinová
authors.forename: P
authors.initials: P
authors.lastname: Sunka
authors.forename: P
authors.initials: P
authors.lastname: Lukeš
authors.forename: H
authors.initials: H
authors.lastname: Kolářová
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology; D003131:Combined Modality Therapy; D054697:Cytostatic Agents / Q000494:pharmacology*; D019220:High-Energy Shock Waves; D008279:Magnetic Resonance Imaging; D009132:Muscles / Q000187:drug effects / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D040521:Subcutaneous Tissue / Q000187:drug effects / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D054697:Cytostatic Agents; D017319:Photosensitizing Agents; D002945:Cisplatin