title: Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion.
abstract: BACKGROUND
  microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.
  
  
  METHODS
  The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.
  
  
  RESULTS
  In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.
  
  
  CONCLUSIONS
  microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.
authors.affiliation: Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi 214062, People's Republic of China. wxsyyujj@gmail.com
authors.forename: Jinjin
authors.initials: J
authors.lastname: Yu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ruofan
authors.initials: R
authors.lastname: Dong
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Huang
authors.forename: Suning
authors.initials: S
authors.lastname: Ding
authors.forename: Haifeng
authors.initials: H
authors.lastname: Qiu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D020133:Reverse Transcriptase Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology*
chemical_list: C547471:MIRN218 microRNA, human; D035683:MicroRNAs