title: Morphofunctional characteristics of the immune system in CBA and C57Bl/6g mice.
abstract: We studied peculiarities of morphofunctional organization of the immune system in C57Bl/6g and CBA mice differing by their susceptibility to various types of infectious agents. The revealed differences in the structure of lymphoid organs, T lymphocyte subpopulation ratio and their differentiation into Th1/Th2 cells after mitogen stimulation drove us to a conclusion on genetically determined regularities in the development of the immune response in these animal strains.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupiy
authors.forename: V O
authors.initials: VO
authors.lastname: Tkachev
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.forename: N G
authors.initials: NG
authors.lastname: Luzgina
authors.forename: J S
authors.initials: JS
authors.lastname: Bugrimova
authors.forename: K S
authors.initials: KS
authors.lastname: Obedinskaya
authors.forename: N S
authors.initials: NS
authors.lastname: Zaiceva
authors.forename: A V
authors.initials: AV
authors.lastname: Chechushkov
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D002454:Cell Differentiation / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D015703:Antigens, CD; D008934:Mitogens