title: Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk.
abstract: Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes - A2756G MTR, A66G MTRR, and 844ins68 CBS - which have putative functional significance in breast cancer risk. The allele and genotype frequencies of the SNPs were determined in a case group (840 women with sporadic breast cancer) and a control group (770 women). No statistically significant association of studied SNPs with breast cancer was revealed. A meta-analysis, which included data obtained from the literature and the present research, did not reveal any statistically significant associations of these SNPs with breast cancer. The results obtained provide evidence that these SNPs are not involved in the development of breast cancer.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Novosibirsk, Russia. weiner.alexserg@gmail.com
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Weiner
authors.forename: Uljana A
authors.initials: UA
authors.lastname: Boyarskikh
authors.forename: Elena N
authors.initials: EN
authors.lastname: Voronina
authors.forename: Inna A
authors.initials: IA
authors.lastname: Selezneva
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Sinkina
authors.forename: Alexandr F
authors.initials: AF
authors.lastname: Lazarev
authors.forename: Valentina D
authors.initials: VD
authors.lastname: Petrova
authors.forename: Maxim L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D003541:Cystathionine beta-Synthase / Q000235:genetics*; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005492:Folic Acid / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D005492:Folic Acid; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D003541:Cystathionine beta-Synthase