title: Three-dimensional conformal versus non-graphic radiation treatment planning for apocrine gland adenocarcinoma of the anal sac in 18 dogs (2002-2007).
abstract: Differences in dose homogeneity and irradiated volumes of target and surrounding normal tissues between 3D conformal radiation treatment planning and simulated non-graphic manual treatment planning were evaluated in 18 dogs with apocrine gland adenocarcinoma of the anal sac. Overall, 3D conformal treatment planning resulted in more homogenous dose distribution to target tissues with lower hot spots and dose ranges. Dose homogeneity and guarantee of not under-dosing target tissues with 3D conformal planning came at the cost, however, of delivering greater mean doses of radiation and of irradiating greater volumes of surrounding normal tissue structures.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Keyerleber
authors.forename: T L
authors.initials: TL
authors.lastname: Gieger
authors.forename: H N
authors.initials: HN
authors.lastname: Erb
authors.forename: M S
authors.initials: MS
authors.lastname: Thompson
authors.forename: M C
authors.initials: MC
authors.lastname: McEntee
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000662:veterinary*; D000694:Anal Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D000695:Anal Sacs / Q000473:pathology*; D000818:Animals; D001050:Apocrine Glands / Q000473:pathology*; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male