title: [Research progress in fusion expression of antimicrobial peptides].
abstract: Antimicrobial peptides (AMPs) are of great significance in the field of food, feed and medicine due to their wide spectrum of antimicrobial activity and new mechanism of action different from conventional antibiotics. AMPs production from natural sources is usually limited, and chemical synthesis is not economically practical, especially for the production of long peptides. Therefore, heterologous expression of AMPs has been widely studied as an alternative, and fusion expression plays an important role in increasing production. The present review mainly focuses on the types and bioactivities of AMPs. In addition, the recent strategies to the most commonly used carrier proteins for fusion expression of AMPs and prospects for future research were also discussed.
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China.
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Ma
authors.forename: Zhanqiao
authors.initials: Z
authors.lastname: Yu
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Rijun
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis* / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000096:biosynthesis / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis* / Q000235:genetics; D013879:Thioredoxins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D013879:Thioredoxins; D005982:Glutathione Transferase