title: Sesquiterpenes from Dysoxylum oliganthum and Dysoxylum excelsum.
abstract: Three new sesquiterpenes (1-3), (6R,7S,11R,10S)-15-hydroxy-sesquisabinene hydrate (1), (6R,7R,11S,10S)-15-hydroxy-sesquisabinene hydrate (2), and (6R,7R,10S)-15-hydroxy-zingiberenol (3), along with three known compounds, were isolated from the stems of Dysoxylum oliganthum; and three new isodaucane (salvionane) sesquiterpenes, namely isodauc-6-ene-10β,14-diol (4), 4-epi-isodauc-6-ene-10β,14-diol (5), and 4-epi-6α,10β-dihydroxy-artabotrol (6) together with 15 known compounds were isolated from the twigs and leaves of D. excelsum. Their structures were established on the basis of extensive spectroscopic analysis and chemical shifts. The absolute configuration of C-10 in compounds 1-3 of a rare class was determined by using Snatzke's method.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Dong
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D029582:Meliaceae / Q000737:chemistry* / Q000235:genetics; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: C571048:(6R,7R,10S)-15-hydroxy-zingiberenol; C571047:(6R,7S,11R,10S)-15-hydroxy-sesquisabinene hydrate; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes