title: LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.
abstract: This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE.
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Shengming 1 Road, DD Port, Dalian 116600, China.
authors.forename: Zhongzhe
authors.initials: Z
authors.lastname: Cheng
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.forename: Yunjiao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhai
authors.forename: Xixiang
authors.initials: X
authors.lastname: Ying
authors.forename: Tingguo
authors.initials: T
authors.lastname: Kang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D047310:Apigenin / Q000493:pharmacokinetics; D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics; D006569:Hesperidin / Q000097:blood / Q000493:pharmacokinetics; D010636:Phenols / Q000097:blood / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D031822:Portulaca / Q000737:chemistry*; D011422:Propionates; D051381:Rats; D015203:Reproducibility of Results
chemical_list: D003373:Coumaric Acids; D010636:Phenols; D010936:Plant Extracts; D011422:Propionates; C021329:vitexin rhamnoside; D047310:Apigenin; C004999:ferulic acid; D006569:Hesperidin; C495469:p-coumaric acid