title: Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR.
abstract: Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPARα/γ agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concerted action of isoflavones.
authors.affiliation: Department of Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Vienna, Austria. svjetlana.medjakovic@boku.ac.at
authors.forename: Svjetlana
authors.initials: S
authors.lastname: Medjakovic
authors.forename: Monika
authors.initials: M
authors.lastname: Mueller
authors.forename: Alois
authors.initials: A
authors.lastname: Jungbauer
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D059447:Cell Cycle Checkpoints; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D024821:Metabolic Syndrome / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007529:Isoflavones; D047492:Peroxisome Proliferator-Activated Receptors; D018336:Receptors, Aryl Hydrocarbon