title: Is there any association between IgA nephropathy, Crohn's disease and Helicobacter pylori infection?
abstract: A case of IgA nephropathy (IgAN) associated with Crohn's disease (CD) and preceded Helicobacter pylori (Hp) infection is described. Therapy with corticosteroids and azathioprine resulted in clinical improvement. The connection between IgAN and CD is well established, while tonsillar Hp is a potential antigen causative of IgAN. The three entities may reflect a common immunopathogenetic mechanism involving an IgA response to mucosal challenge.
authors.affiliation: Department of Nephrology, Aretaieion University Hospital, Athens, Greece. chrysapi2001@gmail.com
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Pipili
authors.forename: Spyridon
authors.initials: S
authors.lastname: Michopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Sotiropoulou
authors.forename: Tzoulia
authors.initials: T
authors.lastname: Mpakirtzi
authors.forename: Eirini
authors.initials: E
authors.lastname: Grapsa
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007113:Immunity, Innate; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D008297:Male; D008875:Middle Aged
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine