title: Case-control study comparing de novo and daptomycin-exposed daptomycin-nonsusceptible Enterococcus infections.
abstract: Understanding factors associated with de novo daptomycin-nonsusceptible Enterococcus (DNSE) infections will aid in better understanding the mechanisms of daptomycin nonsusceptibility. We conducted a case-control study to compare patients with DNSE infections who were daptomycin treatment naïve (n = 9) and those with DNSE infections who had exposure to daptomycin (n = 13). Less frequent exposure to antimicrobials, increased susceptibility to nitrofurantoin and gentamicin, and shorter duration of hospitalization were associated with de novo DNSE infection, suggesting a potential community reservoir.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. tkelesidis@mednet.ucla.edu
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kelesidis
authors.forename: Angela L P
authors.initials: AL
authors.lastname: Chow
authors.forename: Romney
authors.initials: R
authors.lastname: Humphries
authors.forename: Daniel Z
authors.initials: DZ
authors.lastname: Uslan
authors.forename: David
authors.initials: D
authors.lastname: Pegues
mesh_terms: D000704:Analysis of Variance; D016022:Case-Control Studies; D016001:Confidence Intervals; D017576:Daptomycin / Q000494:pharmacology*; D004197:Disease Reservoirs; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006760:Hospitalization; D006801:Humans; D008826:Microbial Sensitivity Tests; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies
chemical_list: D017576:Daptomycin