title: Videostroboscopic and morphological aspects of voice disturbances in patients with larynx atrophy and coexisting hypopharynx cancer.
abstract: Vocal folds play a crucial role in voice production. The physiological vibrations of vocal folds depend on the unchanged multilayered structure of the vocal folds mucosa. Morphological changes of mucosa are the cause of voice quality disorders - dysphonia. The aim of this study was to determine the morphological base of dysphonia in patients with vocal folds atrophy. A group of 24 patients with larynx atrophy confirmed by endoscopic (VLS) and stroboscopic (VLSS) examination of the larynx was included in the study. The morphological assessment of the larynx mucosa was carried out with the use of the transmission electron microscopy (TEM). Ultramorphological examinations revealed changes in the epithelium, basal membrane and lamina propria of the vocal folds mucosa. An increased number of collagenous fibers, fibroblasts with signs of vacuolar degeneration inflammatory cells and a decreased number of blood vessels and pericytes were observed. Morphological changes found in the epithelium, basal membrane and lamina propria of the vocal folds mucosa were the cause of disorders of vocal folds vibrations registered in the stroboscopic examination of the larynx (VLSS).
authors.affiliation: Department of Clinical Phonoaudiology and Logopedics, Medical University of Bialystok, Poland. fono@umwb.edu.pl
authors.forename: Bożena
authors.initials: B
authors.lastname: Kosztyła-Hojna
authors.forename: Anna
authors.initials: A
authors.lastname: Andrzejewska
authors.forename: Diana
authors.initials: D
authors.lastname: Moskal
authors.forename: Joanna
authors.initials: J
authors.lastname: Kasperuk
authors.forename: Dawid
authors.initials: D
authors.lastname: Falkowski
authors.forename: Marek
authors.initials: M
authors.lastname: Rogowski
mesh_terms: D001284:Atrophy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology*; D007013:Hypopharynx / Q000473:pathology; D007820:Laryngeal Mucosa / Q000473:pathology; D007830:Larynx / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D049489:Stroboscopy / Q000379:methods; D014741:Video Recording; D014827:Vocal Cords / Q000473:pathology; D014832:Voice Disorders / Q000473:pathology*; D014833:Voice Quality