title: Synthesis, spectral studies and solvatochromic analysis of novel imidazole derivatives.
abstract: Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated.
authors.affiliation: Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu 608 002, India. jtchalam2005@yahoo.co.in
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Jayabharathi
authors.forename: Venugopal
authors.initials: V
authors.lastname: Thanikachalam
authors.forename: Natesan
authors.initials: N
authors.lastname: Srinivasan
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Venkatesh Perumal
mesh_terms: D000818:Animals; D002417:Cattle; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D012997:Solvents; D013057:Spectrum Analysis
chemical_list: D007093:Imidazoles; D012997:Solvents; D012710:Serum Albumin, Bovine