title: Dependence of aggregate formation of microbubbles upon ultrasound condition and exposure time.
abstract: We have previously reported our attempts to control microbubbles (microcapsules) behavior in flow by primary Bjerknes force to increase the local concentration of the bubbles at a diseased part. However, there was a limitation in efficiency to propel bubbles of μm-order size. Thus we consider that forming aggregates of bubbles is effective to be propelled before entering into an ultrasound field by making use of secondary Bjerknes force under continuous ultrasound exposure. In this study, we observed the phenomena of aggregates formation by confirming variation of diameter and density of aggregates under various conditions of ultrasound exposure. Then we elucidated frequency dependence of the size of aggregates of micro-bubbles.
authors.affiliation: Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan. 50011701301@st.tuat.ac.jp
authors.forename: Ren
authors.initials: R
authors.lastname: Koda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Watarai
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Nakamoto
authors.forename: Taku
authors.initials: T
authors.lastname: Ohta
authors.forename: Kohji
authors.initials: K
authors.lastname: Masuda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Chiba
mesh_terms: D003102:Colloids / Q000737:chemistry* / Q000528:radiation effects*; D004058:Diffusion / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005290:Ferric Compounds / Q000737:chemistry* / Q000528:radiation effects*; D007501:Iron / Q000737:chemistry* / Q000528:radiation effects*; D008422:Materials Testing; D045423:Microbubbles; D009038:Motion; D010087:Oxides / Q000737:chemistry* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
chemical_list: D003102:Colloids; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron