title: Evaluation of laboratory markers of progression of HIV disease to death.
abstract: BACKGROUND
  One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients.
  
  
  METHODS
  A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis.
  
  
  RESULTS
  The sample included 100 patients--57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed.
  
  
  CONCLUSIONS
  A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.
authors.affiliation: Departamento de Patologia, Universidade Federal do Maranhão, São Luis, MA, Brasil. gracaviana@globo.com
authors.forename: Graça Maria de Castro
authors.initials: GM
authors.lastname: Viana
authors.forename: Maria do Desterro Soares Brandão
authors.initials: Mdo D
authors.lastname: Nascimento
authors.forename: Aila de Menezes
authors.initials: Ade M
authors.lastname: Ferreira
authors.forename: Érica Milena Fernandes
authors.initials: ÉM
authors.lastname: Rabelo
authors.forename: João Arnaud
authors.initials: JA
authors.lastname: Diniz Neto
authors.forename: Carolina de Souza
authors.initials: Cde S
authors.lastname: Galvão
authors.forename: Alessandro Carvalho dos
authors.initials: AC
authors.lastname: Santos
authors.forename: Onildo Martins
authors.initials: OM
authors.lastname: Santos Júnior
authors.forename: Rodrigo Artur Souza de
authors.initials: RA
authors.lastname: Oliveira
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Binda Júnior
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology / Q000401:mortality*; D006441:Hemoglobin A / Q000378:metabolism*; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006441:Hemoglobin A; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase