title: Diffuse infiltration of Aspergillus hyphae in the thyroid gland with multinodular goiter.
abstract: A 35-year-old woman presented with a thyroid mass, weakness and shortness of breath of 3 years duration. On physical examination, she had a diffusely enlarged thyroid gland with multiple nodules. There were no signs to suggest immune suppression. The patient farmed and raised livestock. Biochemical tests and hemogram were normal. She underwent surgery, and a histological examination of the surgical specimen revealed nodular hyperplasia. Microscopically, silver methenamine (PASM) stain-positive hyphae that divided into branches at 45° and conidia were detected beside the thyroid capsule, with conidia in the cystic nodule. Moreover, ischemic changes of the thyroid tissue were observed closer to the capsule. We report a case of Aspergillosis of the thyroid of a patient who underwent surgery for a multinodular goiter.
authors.affiliation: Department of Pathology, Medical Faculty of Duzce University, Duzce, Turkey. drhavvaerdem@hotmail.com
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Uzunlar
authors.forename: Umran
authors.initials: U
authors.lastname: Yildirim
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
authors.forename: M Faruk
authors.initials: MF
authors.lastname: Geyik
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D001230:Aspergillus / Q000166:cytology / Q000302:isolation & purification*; D005260:Female; D006042:Goiter / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D025301:Hyphae / Q000166:cytology; D008853:Microscopy; D013172:Spores, Fungal / Q000166:cytology; D013961:Thyroid Gland / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery