title: A fully implantable stimulator with wireless power and data transmission for experimental use in epidural spinal cord stimulation.
abstract: Epidural spinal cord stimulation (ESCS) combined with partial weight bearing therapy (PWBT) has been reported to facilitate recovery of functional walking for individuals after chronic incomplete spinal cord injury. This paper describes a low cost, fully implantable, advanced ESCS stimulator that can be manufactured in a research laboratory for use in small animals. The system is composed of four main parts: an external personal digital assistant (PDA), an external controller, an implantable pulse generator (IPG), lead extension and electrode. The PDA allows the experimenter to program the stimulation parameters through a user-friendly graphical interface. The external controller placed on the rat back communicates with PDA via RF telemetry. The IPG generates the biphasic charge-balanced voltage-regulated pulses, which are delivered to the bipolar electrode by the lead extension to achieve chronic ESCS in freely moving rats. A RF carrier from the Class-E amplifier in the external controller provides both data and power for the implanted circuitry through a closely coupled inductive link. The IPG is hermetically packaged using a silicon elastomer and measures 22 mm × 23 mm × 7 mm with a mass of ~3.78 g.
authors.affiliation: Key Laboratory of Image Processing and Intelligent Control, Department of Control Science & Engineering, Huazhong University of Science & Technology, Wuhan, PR China. xuqi@mail.hust.edu.cn
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Han
authors.forename: Houlun
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D034201:Computers, Handheld; D004599:Electric Stimulation Therapy / Q000295:instrumentation; D004566:Electrodes; D004567:Electrodes, Implanted; D004867:Equipment Design; D006801:Humans; D008280:Magnetics; D011846:Radio Waves; D051381:Rats; D012825:Silicon / Q000737:chemistry; D012867:Skin / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000534:rehabilitation*; D013686:Telemetry / Q000379:methods; D016138:Walking; D059015:Wireless Technology
chemical_list: D012825:Silicon