title: Preparation and characterisation of solid state forms of paracetamol-O-glucuronide.
abstract: The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.
authors.affiliation: Department of Chemistry/Analytical and Biological Chemistry Research Facility, University College Cork, College Road, Cork, Ireland.
authors.forename: John A
authors.initials: JA
authors.lastname: Hayes
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Eccles
authors.forename: Simon E
authors.initials: SE
authors.lastname: Lawrence
authors.forename: Humphrey A
authors.initials: HA
authors.lastname: Moynihan
mesh_terms: D000082:Acetaminophen / Q000138:chemical synthesis* / Q000737:chemistry*; D002236:Carbohydrate Conformation; D020719:Glucuronides / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D020719:Glucuronides; D000082:Acetaminophen