title: [The ABC transporters of Saccharomyces cerevisiae].
abstract: The ABC transporters (ATP Binding Cassette) compose one of the bigest protein family with the great medical, industrial and economical impact. They are found in all organism from bacteria to man. ABC proteins are responsible for resistance of microorganism to antibiotics and fungicides and multidrug resistance of cancer cells. Mutations in ABC transporters genes cause seriuos deseases like cystic fibrosis, adrenoleucodystrophy or ataxia. Transport catalized by ABC proteins is charged with energy from the ATP hydrolysis. The ABC superfamily contains transporters, canals, receptors. Analysis of the Saccharomyces cerevisiae genome allowed to distinguish 30 potential ABC proteins which are classified into 6 subfamilies. The structural and functional similarity of the yeast and human ABC proteins allowes to use the S. cerevisiae as a model organism for ABC transporters characterisation. In this work the present state of knowleadge on yeast S. cerevisiae ABC proteins was summarised.
authors.affiliation: Instytut Biologii Roślin, Zakład Genetyki i Fizjologii Komórki, Uniwersytet Wrocławski, Wrocław. donata.wawrzycka@biol.uni.wroc.pl
authors.forename: Donata
authors.initials: D
authors.lastname: Wawrzycka
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000326:Adrenoleukodystrophy / Q000235:genetics; D001259:Ataxia / Q000235:genetics; D003550:Cystic Fibrosis / Q000235:genetics; D006801:Humans; D009154:Mutation; D016366:Open Reading Frames; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*
chemical_list: D018528:ATP-Binding Cassette Transporters