title: Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters.
abstract: We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. ramsc@uohyd.ernet.in
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: Chintalapudi
authors.initials: C
authors.lastname: Venkaiah
authors.forename: Patoju Murali
authors.initials: PM
authors.lastname: Krishna
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003510:Cyclohexanes / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D003510:Cyclohexanes; D013141:Spiro Compounds