title: Modeling cortical source dynamics and interactions during seizure.
abstract: Mapping the dynamics and spatial topography of brain source processes critically involved in initiating and propagating seizure activity is critical for effective epilepsy diagnosis, intervention, and treatment. In this report we analyze neuronal dynamics before and during epileptic seizures using adaptive multivariate autoregressive (VAR) models applied to maximally-independent (ICA) sources of intracranial EEG (iEEG, ECoG) data recorded from subdural electrodes implanted in a human patient for evaluation of surgery for epilepsy. We visualize the spatial distribution of causal sources and sinks of ictal activity on the cortical surface (gyral and sulcal) using a novel combination of multivariate Granger-causal and graph-theoretic metrics combined with distributed source localization by Sparse Bayesian Learning applied to a multi-scale patch basis. This analysis reveals and visualizes distinct, seizure stage-dependent shifts in inter-component spatiotemporal dynamics and connectivity including the clinically-identified epileptic foci.
authors.affiliation: Department of Cognitive Science and Swartz Center for Computational Neuroscience, Institute for Neural Computation, UCSD, USA. tim@sccn.ucsd.edu
authors.forename: Tim
authors.initials: T
authors.lastname: Mullen
authors.forename: Zeynep Akalin
authors.initials: ZA
authors.lastname: Acar
authors.forename: Gregory
authors.initials: G
authors.lastname: Worrell
authors.forename: Scott
authors.initials: S
authors.lastname: Makeig
mesh_terms: D000465:Algorithms; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity