title: Routine blood tests as predictors of mortality in hip fracture patients.
abstract: OBJECTIVE
  The aim of this study was to assess the evidence for the association between different biochemical markers at admission and mortality through a meta-analysis.
  
  
  METHODS
  PubMed-, Embase-, Cochran Library and the Web of Knowledge were searched for cohort studies.
  
  
  METHODS
  Eligible studies were observational studies with a study population larger than 150 subjects, a mean age above 60 years and a study duration below 730 days.
  
  
  METHODS
  Characteristics of studies and outcomes of all-cause mortality were extracted from the retrieved articles. Data were pooled across studies for the individual biomarker using random- or fixed-effect analysis.
  
  
  RESULTS
  15 eligible studies of 5 different markers on mortality were studied. The following markers were found to be of prognostic value on mortality in hip fracture patients: low haemoglobin (odds ratio, 2.78; 95% confidence interval, 2.17-3.55; P<0.00001, 3148 subjects included), low total lymphocyte count, TLC (odds ratio, 2.60; 95% confidence interval, 1.61-4.20; P<0.00001, 1689 subjects included), low albumin (odds ratio, 1.83; 95% confidence interval, 1.31-2.56; P=0.0004, 1680 subjects included), low albumin/low TLC (odds ratio, 3.00; 95% confidence interval, 1.81-4.99; P<0.0001, 704 subjects included), low albumin/high TLC (odds ratio, 3.39; 95% confidence interval, 1.83-6.29; P=0.0001, 704 subjects included), high creatinine (odds ratio, 1.58; 95% confidence interval, 1.25-1.99; P=0.0001, 3761 subjects included), and high PTH (odds ratio, 15.43; 95% confidence interval, 3.60-66.14; P=0.0002, 525 subjects included).
  
  
  CONCLUSIONS
  Biochemical markers at admission are valid predictors of mortality in hip fracture patients.
authors.affiliation: Department of Orthopaedic Surgery, Bispebjerg University Hospital, 2400 Copenhagen NV, Denmark.
authors.forename: Anne S
authors.initials: AS
authors.lastname: Laulund
authors.forename: Jes B
authors.initials: JB
authors.lastname: Lauritzen
authors.forename: Benn R
authors.initials: BR
authors.lastname: Duus
authors.forename: Mathias
authors.initials: M
authors.lastname: Mosfeldt
authors.forename: Henrik L
authors.initials: HL
authors.lastname: Jørgensen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006454:Hemoglobins / Q000378:metabolism*; D006620:Hip Fractures / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010281:Parathyroid Hormone / Q000097:blood*; D011237:Predictive Value of Tests; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D010281:Parathyroid Hormone; D012709:Serum Albumin; D003404:Creatinine