title: Status of free-radical oxidation and proliferation processes in patients with atopic dermatitis and lichen planus.
abstract: We studied the status of proliferation processes (by Ki-67 expression) and biogenesis of free radicals (by chemiluminescence method) in skin biopsy specimens from patients with atopic dermatitis and lichen planus. The index of Ki-67-positive nuclei significantly (p<0.05) increased to 28.40±2.00% in patients with dermatitis and to 32.6±1.9% in patients with lichen planus vs. 8.65±1.31% in the reference sample. Decompensated accumulation of free-radical oxidation products and inhibition of detoxification systems in skin biopsy specimens indicate the development of local oxidative stress. After therapy consisting of two 10-day courses of thymodepressin injections (0.1%, 1.0 ml) over 30 days, normalization of epidermis proliferation was observed. Labeling index in atopic dermatitis and lichen planus significantly decreased (p<0.05) to 17.00±1.87 and 10.9±1.1%, respectively. The role of free radicals in the development of hyperregeneratory processes during dermatoses is discussed.
authors.affiliation: Department of Dermatology, Central Research Laboratory, Far Eastern State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Khabarovsk, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Sapuntsova
authors.forename: O A
authors.initials: OA
authors.lastname: Lebed'ko
authors.forename: M V
authors.initials: MV
authors.lastname: Shchetkina
authors.forename: M Yu
authors.initials: MY
authors.lastname: Fleyshman
authors.forename: E A
authors.initials: EA
authors.lastname: Kozulin
authors.forename: S S
authors.initials: SS
authors.lastname: Timoshin
mesh_terms: D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008010:Lichen Planus / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008163:Luminescent Measurements; D018384:Oxidative Stress; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012867:Skin / Q000473:pathology* / Q000503:physiopathology
chemical_list: D019394:Ki-67 Antigen; D010455:Peptides; D017382:Reactive Oxygen Species; C449663:thymodepressin