title: Mobile health for drug dose optimisation.
abstract: Mobile health monitoring in the management of long term conditions has potential benefits for patient care, especially when coupled with active adjustment of medication dosage. We report studies of patient-led self-titration of oral glucose lowering medication (OGLM) and insulin in type 2 diabetes, and dose adjustments (including dose increases) in oral chemotherapy for metastatic colorectal or breast cancer. Monitoring compliance was high in each case, and the feasibility of patients self-titrating OGLM or insulin following an agreed treatment plan was demonstrated. Chemotherapy dose increases supported by detailed toxicity profiles collected by phone have also been demonstrated.
authors.affiliation: Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK. mel@robots.ox.ac.uk
authors.forename: Mark E
authors.initials: ME
authors.lastname: Larsen
authors.forename: Andrew
authors.initials: A
authors.lastname: Farmer
authors.forename: Andrew
authors.initials: A
authors.lastname: Weaver
authors.forename: Annie
authors.initials: A
authors.lastname: Young
authors.forename: Lionel
authors.initials: L
authors.lastname: Tarassenko
mesh_terms: D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D015190:Blood Glucose Self-Monitoring; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D017216:Telemedicine / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D007004:Hypoglycemic Agents; D007328:Insulin; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil