title: Splenic tuberculosis in a patient with ankylosing spondylitis treated with adalimumab.
abstract: We present a rare case of splenic tuberculosis in a 42-year old man with long-standing ankylosing spondylitis treated with adalimumab. We review the association between antitumor necrosis factor therapy and splenic tuberculosis. Our case, like many other reported cases, illustrates that the index of suspicion of tuberculosis in patients treated with anti TNF therapies must be high and emphasizes that this rare infection may occur even with negative tuberculosis screening before the initiation of therapy.
authors.affiliation: Federal University of Paraná, Rua lamenha Lins 1110 ap 11a, Rebouças, Curitiba, Paraná, CEP 80250-020. valderilio@hotmail.com
authors.forename: V F
authors.initials: VF
authors.lastname: Azevedo
authors.forename: E
authors.initials: E
authors.lastname: Paiva
authors.forename: T
authors.initials: T
authors.lastname: Tosin
authors.forename: A
authors.initials: A
authors.lastname: Ferreira
authors.forename: A M
authors.initials: AM
authors.lastname: Ferreira
authors.forename: M
authors.initials: M
authors.lastname: Fernandes
mesh_terms: D000068879:Adalimumab; D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology*; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000209:etiology; D014400:Tuberculosis, Splenic / Q000175:diagnosis / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab; D008727:Methotrexate