title: Characteristics of serious complicated gastroduodenal ulcers in Japan.
abstract: OBJECTIVE
  Even in Japan where the incidence of H. pylori infection is high, patients with gastroduodenal ulcers caused by NSAIDs are on the increase. A prospective study was conducted to elucidate the characteristics of gastroduodenal ulcers complicated with ulcerous hemorrhage and perforation among Japanese.
  
  
  METHODS
  The subjects were 305 consecutive cases with hemorrhaging ulcers and 76 consecutive cases with perforated ulcers basis at Kagawa Prefectural Central Hospital between January 2000 and December 2008. These subjects were divided into 3 groups (lowdose aspirin, non-aspirin NSAIDs and non-NSAIDs) and were further stratified by the presence of an H. pylori infection.
  
  
  RESULTS
  The 76 perforating ulcers were composed of 54 non-NSAIDs ulcers and 22 NSAIDs-related ulcers. The 305 hemorrhaging ulcers were composed of 156 non-NSAIDs ulcers, 94 non-aspirin NSAIDs ulcers and 55 on low-dose aspirin. The mortality for the non-aspirin NSAIDs group (12.8%, 12/94) and for the low-dose aspirin group (10.9%, 6/55) was significantly higher (p<0.01 and p<0.05, respectively) than the corresponding figure (2.6%, 4/156) for the non-NSAIDs group. The causes of death were exacerbation of or complications from the background diseases (Charlson Co-morbidity Index 3≤) (Odds ratios (OR) 6.01, 95% CI (1.98-18.89)).
  
  
  CONCLUSIONS
  Approximately 50% of the gastroduodenal ulcers with complications found in Japanese are NSAIDs-related and may take a fatal turn. It is necessary to take measures to prevent the complicated ulcers corresponding to risk factors such as the severity of background diseases.
authors.affiliation: Department of Gastroenterology and Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
authors.forename: Shigenao
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inaba
authors.forename: Motowo
authors.initials: M
authors.lastname: Mizuno
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hori
authors.forename: Masaki
authors.initials: M
authors.lastname: Wato
authors.forename: Kozo
authors.initials: K
authors.lastname: Kawai
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced* / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal