title: Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human             gastric cancer and its clinical significance.
abstract: Immune inhibitory receptors play an important role in organ transplantation,             autoimmune diseases and cancers. Immunoglobulin-like transcript (ILT)2 and ILT3             belong to the inhibitory receptors of the ILT family, which have been reported             to regulate a broad range of cellular functions involved in the immune response.             They contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are             related to immune regulation. Although ILT receptors have been studied in dendritic             cells (DCs), T cells, NK cells and other cell types, the expression and clinical             significance of ILT2 and ILT3 in gastric cancer have yet to be elucidated. Here,             the expression of ILT2 and ILT3 in gastric cancer cell lines and pathologic tissues,             as well as their effects on the cytotoxicity of NK92MI against the gastric cancer             cell lines MKNI with ILT2lowILT3low and HGC-27 with ILT2highILT3high were detected.             The results suggest that ILT2 and ILT3 are expressed with diverse degrees in gastric             cancer cells and tissues, and the expression of ILT2 is related with differentiation             and size of tumors. Furthermore, the cytotoxic activity of NK92MI against the             MKNI cell line was stronger than that against HGC-27. This study indicates that             ILT2 and ILT3 play a key role in gastric cancer immune escape, and ILT2 may be             a new target in the clinical diagnosis and treatment of gastric cancer.
authors.affiliation: Department of Clinical Laboratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Lu
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Xue
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Li
authors.forename: Yuanquan
authors.initials: Y
authors.lastname: Si
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Bian
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Jia
authors.forename: Yunshan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; C105299:LILRB1 protein, human; C107907:LILRB4 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic