title: Direct glycosylation of unprotected and unactivated carbohydrates under mild conditions.
abstract: Ligand exchange acetalization of acetals in the presence of catalytic amounts of mandelic acid and titanium tert-butoxide is reported. This transformation is successfully extended to glycosylation of unprotected and unactivated pentoses. Even unreactive pentoses such as D-arabinose or D-lyxose can be transformed by this new methodology into corresponding isopropyl glycosides.
authors.affiliation: Institute of Chemistry, Humboldt-University, Brook-Taylor Str. 2, 12489 Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Pfaffe
authors.forename: Rainer
authors.initials: R
authors.lastname: Mahrwald
mesh_terms: D000080:Acetals / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D006031:Glycosylation; D008024:Ligands; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry
chemical_list: D000080:Acetals; D002241:Carbohydrates; D008024:Ligands; D012997:Solvents