title: [Embryonic stem cell research].
abstract: Research using human embryonic stem cell (hESC) lines has expanded dramatically because of two attractive capacity; self-renewal and differentiation into almost all cell types. For therapeutic purposes, many researchers are trying to establish methods for maintaining pluripotency in defined xeno-free conditions and scalable culture systems. Banking of hESC lines is important for the wide spread of personalized cell therapy and transplantation. We introduced the ongoing clinical trials using hESC-derived cells in patients with subacute spinal cord injury and Stargardt's macular dystrophy. We also discussed opportunities and an example for the use of hESC in drug discovery. Finally, we introduced transgenic hESC as a disease model.
authors.affiliation: Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University.
authors.forename: Shin
authors.initials: S
authors.lastname: Kadota
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Aiba
authors.forename: Norio
authors.initials: N
authors.lastname: Nakatsuji
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D053595:Embryonic Stem Cells / Q000637:transplantation; D006801:Humans; D014015:Tissue Banks