title: Generalized regional disorder-sensitive-weighting scheme for 3D neuroimaging retrieval.
abstract: 3D functional neuroimaging is used in the diagnosis and management of neurological disorders. The efficient management and analysis of these large imaging datasets has prompted research in the field of content-based image retrieval. In this context, our generalized regional disorder-sensitive-weighting (DSW) scheme gives greater weight to brain regions affected by the diseases than regions that are relatively spared. We used two DSW matrices; one matrix is based on the occurrence maps that highlight abnormal functional regions; the other is based on the regional Fisher discriminant ratio. Our results suggest that our DSW matrices enhance neuroimaging data retrieval and provide a flexible weighting solution for the clinical analysis of different types of neurological disorders.
authors.affiliation: Biomedical and Multimedia Information Technology Research Group, School of Information Technologies, University of Sydney, Australia.
authors.forename: Sidong
authors.initials: S
authors.lastname: Liu
authors.forename: Weidong
authors.initials: W
authors.lastname: Cai
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Wen
authors.forename: Stefan
authors.initials: S
authors.lastname: Eberl
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Fulham
authors.forename: David Dagan
authors.initials: DD
authors.lastname: Feng
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000503:physiopathology; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D003704:Dementia / Q000503:physiopathology; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D020961:Lewy Body Disease / Q000503:physiopathology; D015233:Models, Statistical; D009422:Nervous System Diseases / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods; D011381:Programming Languages; D015203:Reproducibility of Results; D012984:Software