title: Effect of topical dimethylarsinic acid on the expression of apoptosis-related proteins in mouse skin.
abstract: We investigated the effect of the topical application of dimethylarsinic acid (DMA) on skin thickness and the expression of several apoptosis-related proteins in skin. After administration of DMA during pregnancy, skin thickness and skin expression of Bcl-2, Bcl-3, Bad, Bid, and caspases-3, -6, -8, -9, and -12 were examined in dams and their offspring. DMA treatment caused significant increases in skin thickness (p < 0.05) and the expression of Bcl-2, Bad, and capase-12 in the skin of dams at the mRNA and protein levels (p < 0.01). However, maternal exposure to DMA did not significantly alter the expression of the studied apoptosis-related factors in the skin of the offspring. These findings indicate that DMA may induce skin apoptosis, in part, by modulating the expression of Bcl-2, Bad, and caspase-12 in maternal skin. Additionally, our results suggest that maternal exposure to DAM during pregnancy may not induce apoptosis in the skin of the offspring.
authors.affiliation: Department of Health Management, Gimcheon University, Gimcheon, 740-704, Republic of Korea.
authors.forename: Eunju
authors.initials: E
authors.lastname: Kim
authors.forename: Minjeong
authors.initials: M
authors.lastname: Kim
authors.forename: Kyunghwa
authors.initials: K
authors.lastname: Sung
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Hyun
authors.forename: Jungae
authors.initials: J
authors.lastname: Jang
authors.forename: Kisok
authors.initials: K
authors.lastname: Kim
mesh_terms: D000287:Administration, Topical; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002101:Cacodylic Acid / Q000008:administration & dosage / Q000633:toxicity*; D020169:Caspases / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D019254:Genes, bcl-2; D051379:Mice; D008807:Mice, Inbred BALB C; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D002101:Cacodylic Acid; D020169:Caspases