title: Illuminating the functional and structural repertoire of human TBC/RABGAPs.
abstract: The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.
authors.affiliation: National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Marieke A M
authors.initials: MA
authors.lastname: Frasa
authors.forename: Katja T
authors.initials: KT
authors.lastname: Koessmeier
authors.forename: M Reza
authors.initials: MR
authors.lastname: Ahmadian
authors.forename: Vania M M
authors.initials: VM
authors.lastname: Braga
mesh_terms: D001692:Biological Transport / Q000235:genetics / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D054730:Protein Interaction Domains and Motifs / Q000235:genetics / Q000502:physiology; D012106:Research / Q000639:trends; D013329:Structure-Activity Relationship; D013663:Teaching; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D020690:GTPase-Activating Proteins; D008869:Microtubule-Associated Proteins; D020741:rho GTP-Binding Proteins