title: Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats.
abstract: This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
authors.affiliation: Boston University School of Medicine, 72 East Concord Street, Robinson 4400, Boston, MA 02118, USA. mruth@bu.edu
authors.forename: Megan R
authors.initials: MR
authors.lastname: Ruth
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.forename: Howe-Ming
authors.initials: HM
authors.lastname: Yu
authors.forename: Susan
authors.initials: S
authors.lastname: Goruk
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Reaney
authors.forename: Spencer D
authors.initials: SD
authors.lastname: Proctor
authors.forename: Donna F
authors.initials: DF
authors.lastname: Vine
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Field
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D016207:Cytokines / Q000096:biosynthesis*; D004032:Diet; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D007333:Insulin Resistance; D008934:Mitogens / Q000494:pharmacology; D009765:Obesity / Q000378:metabolism*; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000378:metabolism
chemical_list: D016207:Cytokines; D005227:Fatty Acids; D006242:Haptoglobins; D008934:Mitogens; D009829:Oleic Acids; D010743:Phospholipids; D019301:Oleic Acid; C011459:elaidic acid; C050413:11-octadecenoic acid