title: A new arteriovenous fistula model to study the development of neointimal hyperplasia.
abstract: This study describes an alternative arteriovenous fistula (AVF) model in the rat in which the animals develop significant neointimal hyperplasia (NIH) not only at the distal anastomotic site, but also throughout the fistula body. This aortocaval fistula was established by anastomosing the distal end of the renal vein to the abdominal aorta after unilateral nephrectomy. The increased hemodynamic stress resulting from exposing the renal vein to the arterial circulation induced venous NIH as early as 7 days after surgery. This experimental AVF was characterized by the early lack of endothelium, the accumulation of proliferating vascular smooth muscle cells and the neovascularization of the fistula adventitia. In summary, we have described an informative animal model to study the pathobiology of NIH in native AVF.
authors.affiliation: DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Fla. 33136, USA.
authors.forename: Eddie
authors.initials: E
authors.lastname: Manning
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Skartsis
authors.forename: Armando M
authors.initials: AM
authors.lastname: Orta
authors.forename: Omaida C
authors.initials: OC
authors.lastname: Velazquez
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Arif
authors.initials: A
authors.lastname: Asif
authors.forename: Loay H
authors.initials: LH
authors.lastname: Salman
authors.forename: Roberto I
authors.initials: RI
authors.lastname: Vazquez-Padron
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001164:Arteriovenous Fistula / Q000473:pathology*; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D004195:Disease Models, Animal; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D058426:Neointima / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012082:Renal Veins / Q000601:surgery