title: Experimental study of the effects of permafrost microorganisms on the morphofunctional activity of the immune system.
abstract: The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 10(6) microbial bodies caused characteristic dose-dependent effects on the structure and functions of the immune system (thymus and spleen indexes, functional activity of splenic macrophages, cellular and humoral immunity). Doses of PMO stimulating functional activities of both cellular and humoral immunity were detected.
authors.affiliation: Tyumen Research Center, Siberian Division of Russian Academy of Sciences, Russia. lkalenova@mail.ru
authors.forename: L F
authors.initials: LF
authors.lastname: Kalenova
authors.forename: U G
authors.initials: UG
authors.lastname: Suhovey
authors.forename: A V
authors.initials: AV
authors.lastname: Broushkov
authors.forename: V P
authors.initials: VP
authors.lastname: Melnikov
authors.forename: T A
authors.initials: TA
authors.lastname: Fisher
authors.forename: I M
authors.initials: IM
authors.lastname: Besedin
authors.forename: M A
authors.initials: MA
authors.lastname: Novikova
authors.forename: J A
authors.initials: JA
authors.lastname: Efimova
authors.forename: A M
authors.initials: AM
authors.lastname: Subbotin
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology*; D000311:Adrenal Glands / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001407:Bacillus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D002452:Cell Count; D003081:Cold Climate; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012800:Siberia; D012988:Soil Microbiology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism
chemical_list: D012336:RNA, Ribosomal, 16S