title: Association analysis of STX1A gene variants in common forms of migraine.
abstract: OBJECTIVE
  To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports.
  
  
  METHODS
  We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migraine patients and 720 unrelated controls and performed a migraine-specific gene-network analysis.
  
  
  RESULTS
  The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR = 1.56, p = 0.006; p = 0.01 after correction for multiple testing) and migraine without aura (OR = 1.58, p = 0.01; corrected p = 0.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR = 1.47, p = 0.01) and A-C (rs4363087-rs2293489; OR = 0.66, p = 0.01). Combined analysis showed significant association of rs941298 with migraine overall (OR = 1.28, p = 0.004) and migraine without aura (OR = 1.3, p = 0.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A.
  
  
  CONCLUSIONS
  Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.
authors.affiliation: Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King's College London, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Tropeano
authors.forename: Ciçek
authors.initials: C
authors.lastname: Wöber-Bingöl
authors.forename: Andreas
authors.initials: A
authors.lastname: Karwautz
authors.forename: Gudrun
authors.initials: G
authors.lastname: Wagner
authors.forename: Evangelos
authors.initials: E
authors.lastname: Vassos
authors.forename: Sara
authors.initials: S
authors.lastname: Campos-de-Sousa
authors.forename: Andrea
authors.initials: A
authors.lastname: Graggaber
authors.forename: Heidi E
authors.initials: HE
authors.lastname: Zesch
authors.forename: Christian
authors.initials: C
authors.lastname: Kienbacher
authors.forename: Sofia
authors.initials: S
authors.lastname: Natriashvili
authors.forename: Incifer
authors.initials: I
authors.lastname: Kanbur
authors.forename: Christian
authors.initials: C
authors.lastname: Wöber
authors.forename: David A
authors.initials: DA
authors.lastname: Collier
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D010375:Pedigree; D050827:Syntaxin 1 / Q000235:genetics*; D055815:Young Adult
chemical_list: C494212:STX1A protein, human; D050827:Syntaxin 1