title: 2-(2-phenylethyl)chromones from Chinese eaglewood.
abstract: 2-(2-Phenylethyl) chromones and a 2-(2-phenylethenyl) chromone, were isolated from the ethanolic extract of Chinese eaglewood. Their structures were determined on the basis of extensive analyses of spectroscopic data. Among those, one showed significant neuroprotective activities against both glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells at a concentration of 10 μM and increased cell viability by 82.2% and 86.9%, respectively.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Lirui
authors.initials: L
authors.lastname: Qiao
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Yuan
authors.forename: Naihong
authors.initials: N
authors.lastname: Chen
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
authors.forename: Shunxing
authors.initials: S
authors.lastname: Guo
mesh_terms: D000818:Animals; D002470:Cell Survival; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003345:Corticosterone / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018698:Glutamic Acid / Q000009:adverse effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: C572813:6,8-dihydroxy-2-(2-(3'-hydroxy-4'-methoxyphenyl)ethyl)chromone; D002867:Chromones; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D018696:Neuroprotective Agents; C066416:6,7-dimethoxy-2-(2-(4-methoxyphenyl)ethyl)chromone; D000431:Ethanol; D018698:Glutamic Acid; C062550:2-(2-phenylethyl)chromone; D003345:Corticosterone