title: Comparative tissue and body compartment accumulation and maternal transfer to eggs of perfluoroalkyl sulfonates and carboxylates in Great Lakes herring gulls.
abstract: The comparative accumulation of C(4)-C(15) perfluorinated sulfonates (PFSAs) and carboxylates (PFCAs), and several precursors (e.g., perfluorooctane sulfonamide, N-methyl-FOSA, and fluorotelomer unsaturated acids and alcohols) was examined in tissues (liver, brain, muscle, and adipose), plasma/red blood cells (RBCs) and whole egg clutches (yolk and albumen) of female herring gulls collected in 2010 from Chantry Island, Lake Huron of the Laurentian Great Lakes. Highest mean ∑PFSA concentrations were in yolk, followed by adipose, liver, plasma, muscle, RBCs, and brain. Highest mean ∑PFCA concentrations were in yolk, followed by brain, plasma, liver, RBC, adipose and muscle. PFOS accounted for >88% of ∑PFSA in all samples; the liver, plasma/RBCs, muscle and adipose PFCA patterns were dominated by C(8)-C(11) PFCAs, whereas C(10)-C(15) PFCAs in brain and yolk. Among PFSAs and PFCAs there is tissue-specific accumulation, which could be due to a number of pharmacokinetic processes.
authors.affiliation: Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, Canada. wouter_gebbink@carleton.ca
authors.forename: Wouter A
authors.initials: WA
authors.lastname: Gebbink
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Letcher
mesh_terms: D000476:Alkanesulfonates / Q000378:metabolism*; D000818:Animals; D046091:Charadriiformes / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D005466:Fluorocarbons / Q000378:metabolism*; D006114:Great Lakes Region; D008297:Male; D010063:Ovum / Q000737:chemistry / Q000378:metabolism*; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D000476:Alkanesulfonates; D005466:Fluorocarbons; D014874:Water Pollutants, Chemical; C073608:perfluorooctane