title: Chemical constituents from the fruits of Gardenia jasminoides Ellis.
abstract: A new lignan glucoside, (+)-(7S,8R,8'R)-lyoniresinol 9-O-β-D-(6″-O-trans-sinapoyl)glucopyranoside (1), and a new iridoid glucoside, 10-O-trans-sinapoylgeniposide (2), together with eight known compounds, were isolated from the fruits of Gardenia jasminoides Ellis. The structures of the isolates were elucidated by extensive spectroscopic studies, including UV, IR, 1D and 2D NMR, ESI-MS, HR-ESI-MS, and CD experiments. The short-term-memory-enhancement activities of some compounds were evaluated on an Aβ transgenic drosophila model.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Feng
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Zuo-Lei
authors.initials: ZL
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D004330:Drosophila; D005638:Fruit / Q000737:chemistry*; D032062:Gardenia / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008570:Memory, Short-Term / Q000187:drug effects*; D015394:Molecular Structure; D018697:Nootropic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C574597:(7S,8R,8'R)-lyoniresinol 9-O-beta-D-(6''-O-trans-sinapoyl)glucopyranoside; C574598:10-O-trans-sinapoylgeniposide; D006027:Glycosides; D039823:Iridoids; D017705:Lignans; D018697:Nootropic Agents; D010936:Plant Extracts