title: Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report.
abstract: Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm. Rarely, MPNST may display focal mesenchymal differentiation and this is more frequently encountered in high than low grade lesions. Here we present an example of a low grade MPNST with osteoid, cartilaginous and probably smooth muscle components occurring in the subtemporal fossa of a 26-year-old male patient with no associated neurofibromatosis type 1. The tumor exhibited diffuse S-100 protein expression, whereas immunostainings for epithelial membrane antigen and smooth muscle actin were positive in a portion of neoplastic cells.
authors.affiliation: Chair and Department of Pathomorphology, Medical University of Lodz, Poland. karolina.janczar@umed.lodz.pl
authors.forename: Karolina
authors.initials: K
authors.lastname: Janczar
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Tybor
authors.forename: Mateusz
authors.initials: M
authors.lastname: Józefowicz
authors.forename: Wielisław
authors.initials: W
authors.lastname: Papierz
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009455:Neurofibroma / Q000175:diagnosis; D009418:S100 Proteins / Q000378:metabolism; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D018396:Mucin-1; D009418:S100 Proteins