title: Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism.
abstract: OBJECTIVE
  To determine the outcome of patients who underwent pancreatic head resection and Roux-en-Y pancreaticojejunostomy to the remaining normal pancreatic body and tail for the treatment of a focal lesion in the pancreatic head causing congenital hyperinsulinism (HI).
  
  
  METHODS
  One hundred thirty-eight patients underwent pancreatic resection for focal HI between 1998 and 2010. Twenty-three patients in the group underwent pancreatic head resection and Roux-en-Y pancreaticojejunostomy.
  
  
  RESULTS
  There were 13 females and 10 males. Median age and weight at surgery were 8 weeks and 5.8 kg, respectively. Twenty-one patients had a near-total pancreatic head resection, and 2 patients had a pylorus-preserving Whipple procedure. The pancreaticojejunostomy anastomosis was performed with interrupted fine monofilament sutures such that the transected end of the pancreatic body was tucked within the end of the Roux-en-Y jejunal limb. Median hospital stay was 22 days. All patients were cured of HI.
  
  
  CONCLUSIONS
  We conclude that pancreatic head resection with Roux-en-Y pancreaticojejunostomy is a safe and effective procedure for the treatment of the HI patient with a large focal lesion in the pancreatic head that is not amenable to local resection alone.
authors.affiliation: Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Laje
authors.forename: Charles A
authors.initials: CA
authors.lastname: Stanley
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Palladino
authors.forename: Susan A
authors.initials: SA
authors.lastname: Becker
authors.forename: N Scott
authors.initials: NS
authors.lastname: Adzick
mesh_terms: D044903:Congenital Hyperinsulinism / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010179:Pancreas / Q000601:surgery*; D010180:Pancreatectomy / Q000379:methods*; D010193:Pancreaticojejunostomy / Q000379:methods*; D012189:Retrospective Studies