title: Semi-automated segmentation and classification of digital breast tomosynthesis reconstructed images.
abstract: Digital breast tomosynthesis (DBT) is a limited-angle tomographic x-ray imaging technique that reduces the effect of tissue superposition observed in planar mammography. An integrated imaging platform that combines DBT with near infrared spectroscopy (NIRS) to provide co-registered anatomical and functional imaging is under development. Incorporation of anatomic priors can benefit NIRS reconstruction. In this work, we provide a segmentation and classification method to extract potential lesions, as well as adipose, fibroglandular, muscle and skin tissue in reconstructed DBT images that serve as anatomic priors during NIRS reconstruction. The method may also be adaptable for estimating tumor volume, breast glandular content, and for extracting lesion features for potential application to computer aided detection and diagnosis.
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Srinivasan.Vedantham@ umassmed.edu
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vedantham
authors.forename: Linxi
authors.initials: L
authors.lastname: Shi
authors.forename: Andrew
authors.initials: A
authors.lastname: Karellas
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Michaelsen
authors.forename: Venkataramanan
authors.initials: V
authors.lastname: Krishnaswamy
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000465:Algorithms; D016880:Anisotropy; D001940:Breast / Q000473:pathology; D016000:Cluster Analysis; D004058:Diffusion; D004867:Equipment Design; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008027:Light; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000295:instrumentation* / Q000379:methods*; D009132:Muscles / Q000473:pathology; D012542:Scattering, Radiation; D012867:Skin / Q000473:pathology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014965:X-Rays