title: A dual-chambered hemodialyzer for convection-enhanced hemodialysis.
abstract: Convective clearance during hemodialysis (HD) improves dialysis outcomes in kidney failure patients, and, thus, trials have been undertaken to increase convective mass transfer, which is directly related to internal filtration rates. The authors designed a new hemodialyzer to increase the internal filtration rates, and here describe the hemodialytic efficacy of the devised unit. The developed dual-chambered hemodialyzer (DCH) contains two separate chambers for dialysate flow within a single housing. By placing a flow restrictor on the dialysate stream between these two chambers, dialysate pressures are regulated independently. Dialysate is maintained at a higher pressure than blood pressure in one chamber, and at a lower pressure in the other chamber. The dialysis performance of the DCH was investigated using an acute canine renal failure model. Urea and creatinine reductions and albumin loss were monitored, and forward and backward filtration rates were measured. No procedurally related malfunction was encountered, and animals remained stable without any complications. Urea and creatinine reductions after 4-h dialysis treatments were 75.2 ± 6.5% and 67.7 ± 8.9%, respectively. Post-treatment total protein and albumin levels remained at pretreatment values. Total filtration volume was 4.98 ± 0.5 L over 4 h, whereas the corresponding backfiltration (BF) volume was 4.77 ± 0.6 L. The developed dual-chamber dialyzer has the benefit of providing independent control of forward filtration and BF rates. HD using this dialyzer provides a straightforward means of increasing the internal filtration and convective dose.
authors.affiliation: AnC Bio Inc., and Interdisciplinary Program in Bioengineering, Seoul National University Department of Biomedical Engineering, Seoul National University, Seoul, Korea. jake0902@snu.ac.kr
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Lee
authors.forename: Cho Hae
authors.initials: CH
authors.lastname: Mun
authors.forename: Byoung Goo
authors.initials: BG
authors.lastname: Min
authors.forename: Yong Soon
authors.initials: YS
authors.lastname: Won
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000818:Animals; D018481:Convection; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004867:Equipment Design; D006435:Renal Dialysis / Q000295:instrumentation*; D012709:Serum Albumin / Q000032:analysis; D014462:Ultrafiltration / Q000295:instrumentation
chemical_list: D012709:Serum Albumin; D003404:Creatinine