title: Evaluation of α-D-ribofuranose (D-ribose) toxicity after intravenous administration to rabbits.
abstract: Rapid intravenous administration of D-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac diseases requires a comprehensive assessment of potential toxic effects of the drug in laboratory animals and in human beings. The potential clinical, behavioral, hematological, biochemical, gross pathological and histological toxic effects associated with the intravenous administration of D-ribose in rabbits for 28 days were evaluated in this study. Except for an increase in neutrophil percentage in male rabbits in the D-ribose-treated groups, there were no statistically significant toxic effects induced by daily intravenous administration of the drug in male and female rabbits. Results of this study suggest that D-ribose administered intravenously for 28 days in the rabbit exhibited no toxicity at 420 mg/kg.
authors.affiliation: Jordan University of Science and Technology, Irbid, Jordan. zuhair72@just.edu.jo
authors.forename: Z Bani
authors.initials: ZB
authors.lastname: Ismail
authors.forename: N
authors.initials: N
authors.lastname: Abu-Baker
authors.forename: K
authors.initials: K
authors.lastname: Alzoubi
authors.forename: M
authors.initials: M
authors.lastname: Al-Zhgoul
authors.forename: M K
authors.initials: MK
authors.lastname: Al-Essa
authors.forename: S
authors.initials: S
authors.lastname: Khlouf
authors.forename: A
authors.initials: A
authors.lastname: Al-Saleh
authors.forename: B
authors.initials: B
authors.lastname: Al-Omari
authors.forename: R
authors.initials: R
authors.lastname: Abu-Tayeh
authors.forename: M
authors.initials: M
authors.lastname: Shomaf
authors.forename: A
authors.initials: A
authors.lastname: Battah
authors.forename: K
authors.initials: K
authors.lastname: Al-Hadidi
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D005260:Female; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D020011:Protective Agents / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D012266:Ribose / Q000008:administration & dosage / Q000633:toxicity*; D059551:Toxicity Tests, Subacute
chemical_list: D020011:Protective Agents; D012266:Ribose