title: Changes in the concentration of monocytic chemotaxic protein-1 in patients with unstable angina treated with arixtra.
abstract: The time course of inflammatory reaction markers in the blood of patients with unstable angina was studied during therapy including arixtra. Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. After 1 month, MCP-1 level decreased in all patients. The concentration of highly sensitive C-reactive protein also decreased 1 month after the disease onset; no changes in the concentrations of IL-8 and IL-2 receptor α-subunit were detected during these periods. It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration.
authors.affiliation: Russian Research and Practical Centre of Cardiology, Moscow, Russia. potehina@gmail.com
authors.forename: A V
authors.initials: AV
authors.lastname: Potekhina
authors.forename: T I
authors.initials: TI
authors.lastname: Arefieva
authors.forename: T L
authors.initials: TL
authors.lastname: Krasnikova
authors.forename: S I
authors.initials: SI
authors.lastname: Provatorov
authors.forename: V P
authors.initials: VP
authors.lastname: Masenko
authors.forename: M K
authors.initials: MK
authors.lastname: Osyaeva
authors.forename: E A
authors.initials: EA
authors.lastname: Noeva
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D000077425:Fondaparinux; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; C508606:CXCL8 protein, human; D018932:Chemokine CCL2; C508017:IL2RA protein, human; C508600:IL6 protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D015850:Interleukin-6; D016209:Interleukin-8; D011134:Polysaccharides; D002097:C-Reactive Protein; D000077425:Fondaparinux