title: Second messengers cAMP, Ca2+, and NO modulate functional properties of human lymphocytes under conditions of exposure to UV light.
abstract: We studied the effect of UV light (240-390 nm) in doses of 75.5-4530 J/m(2) on functional properties and level of intracellular messengers (cAMP, Ca(2+), NO) in lymphocytic cells of the peripheral blood. Correcting effects of UV light in a dose of 151 J/m(2) on cytotoxic activity of lymphocytes against Ehrlich ascetic carcinoma and calcium concentration in lymphocyte cytosol were observed. We found that UV light reduces the cAMP content and increases NO concentration (151-4530 J/m(2)) in photomodified cells. The involvement of adenylate cyclase and phosphoinositide signaling pathway into the mechanisms of modulation of functional properties of lymphocytes after exposure to UV light was demonstrated.
authors.affiliation: Voronezh State University, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Nakvasina
authors.forename: O V
authors.initials: OV
authors.lastname: Lidokhova
authors.forename: L I
authors.initials: LI
authors.lastname: Popova
authors.forename: M S
authors.initials: MS
authors.lastname: Trubitsyna
authors.forename: V G
authors.initials: VG
authors.lastname: Artyukhov
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000032:analysis*; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D009569:Nitric Oxide; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium