title: [Amiodarone and thyroid dysfunction].
abstract: Amiodarone is a structural analogue of thyroid hormone, and some of its anti-arrhythmic actions and toxicity are attributable to its interaction with nuclear receptors of thyroid hormones. Being highly lipophilic, amiodarone is concentrated in many tissues and is eliminated, consequently, very slowly. It is preferably employed to manage life-threatening arrhythmias, including ventricular fibrillation and unstable ventricular tachycardia. Other indications include atrial fibrillation and flutter, severe congestive heart failure, prevention of atrial fibrillation recurrence, and even in emergency medical situations to prevent sudden cardiac death. The aim of this review is to provide an updated approach on amiodarone and its influence on thyroid physiology and to discuss and analyze in depth its potential and not infrequent thyroidal adverse effects such as hypothyroidism and thyrotoxicosis.
authors.affiliation: Estudios Metabólicos y Endocrinos, Buenos Aires. elbylen@yahoo.com.ar
authors.forename: Leonardo F L
authors.initials: LF
authors.lastname: Rizzo
authors.forename: Oscar D
authors.initials: OD
authors.lastname: Bruno
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics; D001281:Atrial Fibrillation / Q000188:drug therapy; D000077764:Dronedarone; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000628:therapy; D007455:Iodine / Q000032:analysis; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D007455:Iodine; D000077764:Dronedarone; D000638:Amiodarone