title: Diagnostic tools assessing airway remodelling in asthma.
abstract: Asthma is an inflammatory disease of the lower airways characterised by the presence of airway inflammation, reversible airflow obstruction and airway hyperresponsiveness and alterations on the normal structure of the airways, known as remodelling. Remodelling is characterised by the presence of metaplasia of mucous glands, thickening of the lamina reticularis, increased angiogenesis, subepithelial fibrosis and smooth muscle hypertrophy/hyperplasia. Several techniques are being optimised at present to achieve a suitable diagnosis for remodelling. Diagnostic tools could be divided into two groups, namely invasive and non-invasive methods. Invasive techniques bring us information about bronchial structural alterations, obtaining this information directly from pathological tissue, and permit measure histological modification placed in bronchi layers as well as inflammatory and fibrotic cell infiltration. Non-invasive techniques were developed to reduce invasive methods disadvantages and measure airway remodelling-related markers such as cytokines, inflammatory mediators and others. An exhaustive review of diagnostic tools used to analyse airway remodelling in asthma, including the most useful and usually employed methods, as well as the principal advantages and disadvantages of each of them, bring us concrete and summarised information about all techniques used to evaluate alterations on the structure of the airways. A deep knowledge of these diagnostic tools will make an early diagnosis of airway remodelling possible and, probably, early diagnosis will play an important role in the near future of asthma.
authors.affiliation: Allergy Department, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. mansomd@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Manso
authors.forename: M
authors.initials: M
authors.lastname: Reche
authors.forename: M A
authors.initials: MA
authors.lastname: Padial
authors.forename: T
authors.initials: T
authors.lastname: Valbuena
authors.forename: C
authors.initials: C
authors.lastname: Pascual
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D001980:Bronchi / Q000473:pathology*; D003955:Diagnostic Tests, Routine; D042241:Early Diagnosis; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D018919:Neovascularization, Physiologic; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology