title: Two new oleanane-type pentacyclic triterpenoid saponins from the husks of Xanthoceras sorbifolia Bunge.
abstract: Two new triterpenoid saponins (1, 2) and a known saponin (3) were isolated from the husks of Xanthoceras sorbifolia Bunge., and their structures were elucidated as 3-O-β-D-glucopyranosyl(1 → 6)-[angeloyl(1 → 2)]-β-D-glucopyranosyl-28-O-α-L-rhamnopyranosyl(1 → 2)-[β-D-glucopyranosyl(1 → 6)]-β-D-glucopyranosyl-21β,22α-dihydroxyl-olean-12-ene (1), 3-O-β-D-glucopyranosyl-28-O-[β-D-glucopyranosyl(1 → 2)]-β-D-glucopyranosyl-21β,22α-dihydroxyl-olean-12-ene (2), and 3-O-β-D-glucopyranosyl-28-O-[α-L-rhamnopyranosyl(1 → 2)]-β-D-glucopyranosyl-21β,22α-dihydroxyl-olean-12-ene (3), on the basis of the spectral analysis of NMR and chemical methods. Cytotoxic assay indicated that none of them showed obvious inhibitory effect on the proliferation of two human tumor cell lines.
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Cui
authors.forename: Hang
authors.initials: H
authors.lastname: Xiao
authors.forename: Xiao-Ku
authors.initials: XK
authors.lastname: Ran
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Li
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Dou
authors.forename: Ting-Guo
authors.initials: TG
authors.lastname: Kang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C571045:3-O-beta-D-glucopyranosyl(1-6)-(angeloyl(1-2))-beta-D-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl(1-2)-(beta-D-glucopyranosyl(1-6))-beta-D-glucopyranosyl-21beta,22alpha-dihydroxyl-olean-12-ene; C571046:3-O-beta-D-glucopyranosyl-28-O-(beta-D-glucopyranosyl(1-2))-beta-D-glucopyranosyl-21beta,22alpha-dihydroxyl-olean-12-ene; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid