title: Using extracellular matrix-derived peptides to alter the microenvironment for myocardial repair.
abstract: Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.
authors.affiliation: University of California San Francisco, Francisco, CA 94143, USA.
authors.forename: Shirley S
authors.initials: SS
authors.lastname: Mihardja
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Lee
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage; D000818:Animals; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000008:administration & dosage; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000379:methods*; D020257:Ventricular Remodeling
chemical_list: D043925:Angiogenesis Inducing Agents; D016326:Extracellular Matrix Proteins