title: Light fluorous-tagged traceless one-pot synthesis of benzimidazoles facilitated by microwave irradiation.
abstract: A novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Tseng
authors.forename: Cheng-Hsun
authors.initials: CH
authors.lastname: Tasi
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D052616:Solid Phase Extraction; D013237:Stereoisomerism
chemical_list: D001562:Benzimidazoles; D006845:Hydrocarbons, Fluorinated