title: Two new triterpenoid saponins from Caragana microphylla seeds.
abstract: Two new triterpenoid saponins, caraganins A and B (1 and 2), structurally characterized by a 22-oxo group, were isolated from the seeds of Caragana microphylla Lam., together with their n-butyl esters as artifacts (1a and 2a). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Compounds 1a and 2a exhibited potent antibacterial activity against Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration values ranging from 3.125 to 6.25 μg/ml.
authors.affiliation: Department of Pharmacognosy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Jin
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Zou
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Jiang
authors.forename: Pei-Xin
authors.initials: PX
authors.lastname: Sun
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D032602:Caragana / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012503:Saponins / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D012503:Saponins; D014315:Triterpenes