title: Toxicokinetics of naringin and its metabolite naringenin after 180-day repeated oral administration in beagle dogs assayed by a rapid resolution liquid chromatography/tandem mass spectrometric method.
abstract: Toxicokinetic characteristics of naringin and its metabolite naringenin were investigated in beagle dogs after oral administration of naringin at the doses of 20, 100, or 500 mg/kg/day in a repeated-dose study for 1, 30, 90, and 180 days. Plasma concentrations of naringin and naringenin were determined by a rapid resolution liquid chromatography/electrospray ionization/tandem mass spectrometric method. The results showed that no differences in systemic exposure were observed between male and female beagle dogs. Systematic exposure exhibited dose-dependent increase for both naringin and naringenin. No significant accumulations were observed. Results would be taken into consideration for the interpretation of toxicology findings and provide a reference for clinical safety assessment.
authors.affiliation: School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Yang
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zou
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Guan
authors.forename: Li
authors.initials: L
authors.lastname: Lai
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Su
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002853:Chromatography, Liquid; D002957:Citrus / Q000737:chemistry; D004285:Dogs; D005260:Female; D044950:Flavanones / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D044950:Flavanones; C005273:naringenin; C005274:naringin