title: Engineering the robustness of industrial microbes through synthetic biology.
abstract: Microbial fermentations and bioconversions play a central role in the production of pharmaceuticals, enzymes and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximized carbon flux towards target metabolites regardless of fluctuations in intracellular or extracellular environments. This requires cellular systems that maintain functional stability and dynamic homeostasis in a given physiological state, or manipulate transitions between different physiological states. Stable maintenance or smooth transition can be achieved through engineering of dynamic controllability, modular and hierarchical organization, or functional redundancy, three key features of biological robustness in a cellular system. This review summarizes how synthetic biology can be used to improve the robustness of industrial microbes.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Linjiang
authors.initials: L
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
mesh_terms: D001419:Bacteria / Q000235:genetics*; D025461:Feedback, Physiological; D005658:Fungi / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D015966:Gene Expression Regulation, Fungal; D053263:Gene Regulatory Networks; D005818:Genetic Engineering / Q000379:methods; D007218:Industrial Microbiology; D015398:Signal Transduction / Q000235:genetics; D058615:Synthetic Biology