title: Effect of aqueous extract of Cochlospermum planchonii rhizome on some kidney and liver functional indicies of albino rats.
abstract: Aqueous extract of Cochlospermum planchonii Hook. Ef. x Planch rhizome was investigated for its toxic effects in albino rats using some liver and kidney functional indices as 'markers'. Thirty six albino rats weighing 200.08 ± 10.21 were randomly assinged into six groups (A-F) of six animals each. Animals in groups A-E were orally administered on daily basis with 1 ml of the extract corresponding to 50 mg/kg body weight of the extract for 1, 3, 5, 10 and 15 days while those in the control group received orally 1 ml of distilled water. Rats in all the groups were sacrificed 24 hours after the completion of their respective doses. The extract significantly (P<0.05) decreased alkaline phosphatase (ALP) activities in the liver leading to 80.95% loss by the end of the experimental period. While there was no consistent pattern in the kidney ALP activity and serum bilirubin level, the serum enzyme compared well (P>0.05) with the control value. There was no effect (P>0.05) on the acid phosphatase activity of the tissues and serum of the animals. The extract also reduced the urea, albumin and creatinine content in the serum of the animals. The alterations in the biochemical parameters by the aqueous extract of Cochlospermum planchoni may have consequential effects on the normal functioning of the liver and kidney of the animals. Therefore, the 50 mg/kg body weight of the aqueous extract of Cochlospermum planchoni rhizome may not be completley safe as an oral remedy.
authors.affiliation: Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
authors.forename: Mo
authors.initials: M
authors.lastname: Nafiu
authors.forename: M A
authors.initials: MA
authors.lastname: Akanji
authors.forename: M T
authors.initials: MT
authors.lastname: Yakubu
mesh_terms: D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D031212:Bixaceae / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D016488:Medicine, African Traditional; D009549:Nigeria; D008517:Phytotherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry
chemical_list: D015415:Biomarkers; D010936:Plant Extracts; D000469:Alkaline Phosphatase; D001663:Bilirubin