title: Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy.
abstract: Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, has provided a novel area of targets for cancer immunotherapy. This has resulted in the development of a number of vaccines and monoclonal antibodies that are showing promising results in recent clinical trials.
authors.affiliation: Academic Department of Clinical Oncology, Molecular Medical Sciences, City Hospital, University of Nottingham, Nottingham, UK. lindy.durrant@nottingham.ac.uk
authors.forename: L G
authors.initials: LG
authors.lastname: Durrant
authors.forename: P
authors.initials: P
authors.lastname: Noble
authors.forename: I
authors.initials: I
authors.lastname: Spendlove
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002518:Ceramides / Q000378:metabolism; D002986:Clinical Trials as Topic; D005679:G(M3) Ganglioside / Q000031:analogs & derivatives / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D006017:Glycolipids / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007983:Lewis Blood Group Antigens / Q000276:immunology; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D014312:Trisaccharides / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D002518:Ceramides; D005679:G(M3) Ganglioside; D005732:Gangliosides; D006017:Glycolipids; D007983:Lewis Blood Group Antigens; D014312:Trisaccharides; C105622:galactosyl-beta(1-3)-N-acetylglucosaminyl-beta(1-3)galactose; C044298:N-glycolylneuraminyllactosylceramide