title: Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.
abstract: Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer models, licensing of γδ T cells by tumor-reactive mAbs promotes the uptake of tumor Ags and professional presentation to tumor-reactive αβ T cells. We propose that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner.
authors.affiliation: Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London WCN1 1EH, UK.
authors.forename: Nourredine
authors.initials: N
authors.lastname: Himoudi
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Morgenstern
authors.forename: Mengyong
authors.initials: M
authors.lastname: Yan
authors.forename: Bertrand
authors.initials: B
authors.lastname: Vernay
authors.forename: Luisa
authors.initials: L
authors.lastname: Saraiva
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.forename: Cyrille J
authors.initials: CJ
authors.lastname: Cohen
authors.forename: Kenth
authors.initials: K
authors.lastname: Gustafsson
authors.forename: John
authors.initials: J
authors.lastname: Anderson
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000276:immunology; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology*; D010587:Phagocytosis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta