title: Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate.
abstract: High amylose and pectin were mixed at 1:1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, SP, Brazil.
authors.forename: Fabíola Garavello
authors.initials: FG
authors.lastname: Prezotti
authors.forename: Andréia Bagliotti
authors.initials: AB
authors.lastname: Meneguin
authors.forename: Raul Cesar
authors.initials: RC
authors.lastname: Evangelista
authors.forename: Beatriz Stringhetti Ferreira
authors.initials: BS
authors.lastname: Cury
mesh_terms: D000688:Amylose / Q000737:chemistry*; D003106:Colon / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D010194:Pancreatin / Q000737:chemistry; D010368:Pectins / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D013718:Tensile Strength; D013816:Thermodynamics
chemical_list: D003432:Cross-Linking Reagents; D004337:Drug Carriers; D011122:Polyphosphates; D010194:Pancreatin; D010368:Pectins; D000688:Amylose; C009293:trimetaphosphoric acid