title: Surgery versus radiation therapy for stage IB2 cervical carcinoma: a population-based analysis.
abstract: OBJECTIVE
  The objective of the study was to examine outcomes in stage IB2 cervical cancer patients undergoing primary surgery versus radiation.
  
  
  METHODS
  Stage IB2 cervical cancer patients were identified from the Surveillance, Epidemiology and End Results Public-Use Database from 2000 to 2006. Patients were divided into those receiving radiation (radiation first) or surgery (surgery first) as initial treatment. Overall survival was calculated by Kaplan-Meier method and compared using log-rank test.
  
  
  RESULTS
  In total, 770 patients were identified with stage IB2 cervical cancer; 369 received radiation, and 401 received surgery initially. The radiation-first group had larger mean tumor size than the surgery-first group (6.0 vs 5.5 cm, respectively; P < 0.0001). The overall survival was longer in the surgery-first group compared with the radiation-first group (72.0 vs 61.4 months, respectively; P < 0.0001).
  
  
  CONCLUSIONS
  Patients undergoing surgery as initial treatment for stage IB2 cervical cancer appear to have improved outcomes in the current era of chemoradiation; however, given the lack of chemotherapy information, a randomized trial will be necessary to see if these results remain valid.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Women's Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: Bunja
authors.initials: B
authors.lastname: Rungruang
authors.forename: Madeleine
authors.initials: M
authors.lastname: Courtney-Brooks
authors.forename: Sushil
authors.initials: S
authors.lastname: Beriwal
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Zorn
authors.forename: Scott D
authors.initials: SD
authors.lastname: Richard
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Olawaiye
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Krivak
authors.forename: Paniti
authors.initials: P
authors.lastname: Sukumvanich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011153:Population; D012042:Registries; D016019:Survival Analysis; D047368:Tumor Burden / Q000502:physiology; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D055815:Young Adult