title: Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.
abstract: The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ϵ4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.
authors.affiliation: Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia. y.lim@mhri.edu.au
authors.forename: Yen Ying
authors.initials: YY
authors.lastname: Lim
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Ellis
authors.forename: Karra
authors.initials: K
authors.lastname: Harrington
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.forename: Ralph N
authors.initials: RN
authors.lastname: Martins
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: Christopher
authors.initials: C
authors.lastname: Rowe
authors.forename: Greg
authors.initials: G
authors.lastname: Savage
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
authors.forename: David
authors.initials: D
authors.lastname: Darby
authors.forename: Paul
authors.initials: P
authors.lastname: Maruff
authors.lastname: The Aibl Research Group
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology*; D001288:Attention; D001315:Australia; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics; D015203:Reproducibility of Results