title: Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis.
abstract: OBJECTIVE
  Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis.
  
  
  METHODS
  Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.
  
  
  RESULTS
  The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen (r = -0.729, P = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, P = 0.026).
  
  
  CONCLUSIONS
  Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer.
  
  
  CONCLUSIONS
  • Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen • There is also negative correlation between ADCs and vascular endothelial growth factor • ADC values may contribute to the treatment of oesophageal cancer.
authors.affiliation: Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. aotomo@d2.dion.ne.jp
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Aoyagi
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Okazumi
authors.forename: Kohichi
authors.initials: K
authors.lastname: Hayano
authors.forename: Asami
authors.initials: A
authors.lastname: Satoh
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Saitoh
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nabeya
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kazama
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D003094:Collagen / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D003094:Collagen