title: Molecular evolution of respiratory syncytial virus fusion gene, Canada, 2006-2010.
abstract: To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006-2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.
authors.affiliation: McGill University Health Centre, Montréal, Québec, Canada.
authors.forename: Jesse
authors.initials: J
authors.lastname: Papenburg
authors.forename: Julie
authors.initials: J
authors.lastname: Carbonneau
authors.forename: Marie-Ève
authors.initials: MÈ
authors.lastname: Hamelin
authors.forename: Sandra
authors.initials: S
authors.lastname: Isabel
authors.forename: Xavier
authors.initials: X
authors.lastname: Bouhy
authors.forename: Najwa
authors.initials: N
authors.lastname: Ohoumanne
authors.forename: Pierre
authors.initials: P
authors.lastname: Déry
authors.forename: Bosco A
authors.initials: BA
authors.lastname: Paes
authors.forename: Jacques
authors.initials: J
authors.lastname: Corbeil
authors.forename: Michel G
authors.initials: MG
authors.lastname: Bergeron
authors.forename: Gaston
authors.initials: G
authors.lastname: De Serres
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D019143:Evolution, Molecular; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000821:virology*; D012136:Respiratory Syncytial Viruses / Q000235:genetics*; D014760:Viral Fusion Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014760:Viral Fusion Proteins