title: Costameric proteins: from benchside to future translational cardiovascular research.
abstract: Costameres encircle the myocyte perpendicular to its long axis, and comprise two protein complexes: the dystrophin-glycoprotein complex (DGC) and the vinculin-talin-integrin system. They participate in signaling functions and protect muscle cells from damage induced by workload. The behaviour of those proteins has been a focus of study starting from skeletal and smooth muscle cells to cardiomyocytes, and still represents a topical subject for cardiovascular translational research. This review summarizes the past and present novel approaches of our and other groups of work on this subject of research.
authors.affiliation: Department of Biomorphology and Biotechnologies, School of Medicine, University of Messina, Messina, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Cutroneo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lentini
authors.forename: Angelo
authors.initials: A
authors.lastname: Favaloro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Anastasi
authors.forename: Debora
authors.initials: D
authors.lastname: Di Mauro
mesh_terms: D002319:Cardiovascular System / Q000648:ultrastructure*; D054974:Costameres; D005544:Forecasting; D006801:Humans; D009124:Muscle Proteins / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000648:ultrastructure; D009130:Muscle, Smooth / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000648:ultrastructure; D057170:Translational Research, Biomedical / Q000639:trends
chemical_list: D009124:Muscle Proteins