title: Replication of the Frank-Starling response in a mock circulation loop.
abstract: Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.
authors.affiliation: Faculty of Built Environment and Engineering and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. shaun.gregory@qut.edu.au
authors.forename: Shaun D
authors.initials: SD
authors.lastname: Gregory
authors.forename: Michael
authors.initials: M
authors.lastname: Stevens
authors.forename: Daniel
authors.initials: D
authors.lastname: Timms
authors.forename: Mark
authors.initials: M
authors.lastname: Pearcy
mesh_terms: D001703:Biophysics / Q000379:methods; D002319:Cardiovascular System; D003971:Diastole; D004867:Equipment Design; D006321:Heart / Q000502:physiology; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D011312:Pressure; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000502:physiology; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*