title: Parieto-temporal alpha EEG band power at baseline as a predictor of antidepressant treatment response with repetitive Transcranial Magnetic Stimulation: a preliminary study.
abstract: BACKGROUND
  The aim of this preliminary study was to determine the predictive value of absolute alpha band power measured during the rest EEG eyes closed task for responses to 20 sessions of high frequency repetitive transcranial stimulation (rTMS) in the left dorsolateral prefrontal cortex in patients with pharmacoresistant major depressive episode.
  
  
  METHODS
  13 major depressive disorders (8 males) and 8 bipolar disorders (6 males) were included (mean age 58years). Spearman correlations between pretreatment alpha band power in height regions of analysis and absolute improvement in Beck Depression Inventory Short Form (ΔBDI-SF) were analyzed. The predictive value of alpha band power for classifying patients as responders and non-responders to rTMS was determined using Receiver Operating Characteristic (ROC) curve.
  
  
  RESULTS
  Spearman correlation analysis revealed that ΔBDI-SF correlated significantly and negatively with alpha band power on the right (r=-.673, p=.001) and left parieto-temporal regions (r=-.638, p=.002). The area under the ROC curve for the right parieto-temporal was .815, p=.0037. The cut-off point that maximized both sensitivity and specificity was 1.49μV. Sensitivity, specificity, positive and negative predictive values were 100, 66, 80, 100% respectively.
  
  
  CONCLUSIONS
  The population was small and lacked homogeneity concerning affective disorders (unipolar and bipolar disorder). The use of a self-rating subjective scale (BDI-SF) to measure the severity of depression could be criticized.
  
  
  CONCLUSIONS
  Pretreatment alpha band power on parieto-temporal regions could be a predictor for response to rTMS in patients with homogenous demographic/clinical features. The association between electrical activity and the perfusion under each electrode need to be examined.
authors.affiliation: Pôle de Psychiatrie Solaris, Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Boulevard de Sainte-Marguerite, Marseille, France. jarthur.micoulaud@gmail.com
authors.forename: Jean-Arthur
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.forename: Michel
authors.initials: M
authors.lastname: Cermolacce
authors.forename: Anderson
authors.initials: A
authors.lastname: Loundou
authors.forename: Christophe
authors.initials: C
authors.lastname: Lancon
authors.forename: Jean
authors.initials: J
authors.lastname: Vion-Dury
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000628:therapy*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D061218:Depressive Disorder, Treatment-Resistant / Q000628:therapy*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D050781:Transcranial Magnetic Stimulation
chemical_list: D000928:Antidepressive Agents