title: The Q10 questionnaire for detection of wearing-off phenomena in Parkinson's disease.
abstract: In Parkinson's disease (PD), wearing-off can be difficult to detect as it is very variable and may affect motor and non-motor symptoms. The Wearing-Off Questionnaire, WOQ-32 (Stacy et al., 2005), was introduced to help identify wearing-off and proved to be very efficient. Two short versions of the questionnaire (WOQ-19 or QUICK and WOQ-9) were later developed to decrease the respondent burden without loss of efficacy in terms of sensitivity. The objective of the present study was to check the ability of a new 10-item QUICK version, Q10, to identify patients with wearing-off. Q10 items were selected from the QUICK validation study data set through statistical analysis and it was then tested on a sample of 162 PD patients, 64.8% with wearing-off. Sensitivity, specificity, and accuracy were 96%, 63%, and 85% respectively with one positive response and 90%, 70%, and 83% respectively with two positive responses. The correlation with the gold standard (neurologist diagnosis of wearing-off) was substantial (kappa = 0.62-0.64). Comparison with the QUICK and WOQ-9 shows that the Q10 can be a new tool for detection of wearing-off with satisfactory properties and a good balance between brevity and performance.
authors.affiliation: Alzheimer Disease Research Unit, CIEN Foundation-Reina Sofia Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain. pmartinez@fundacioncien.es
authors.forename: Pablo
authors.initials: P
authors.lastname: Martinez-Martin
authors.forename: Basilio
authors.initials: B
authors.lastname: Hernandez
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D015259:Dopamine Agents / Q000627:therapeutic use; D004351:Drug Resistance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D013030:Spain; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents