title: Relationship between apoptosis and expression of heat shock proteins in peripheral blood lymphocytes of patients with myocardial infarction.
abstract: We studied activity and dynamics of apoptosis of peripheral blood lymphocytes in patients with myocardial infarction and analyzed the relationship of these processes with expression of heat shock proteins with a molecular weight of 70 kDa playing an essential role in preventing cell death. Thus, we first demonstrated activation of apoptosis in peripheral blood cells of patients with myocardial infarction compared to the control (healthy individuals) and revealed the expected negative correlation between the expression of heat shock proteins with a molecular weight of 70 kDa by lymphocytes and intensity of their death. The observed dynamics of mononuclear cell apoptosis in the peripheral blood of patients with myocardial infarction can reflect activity of programmed cardiomyocyte death in the focus of ischemic injury.
authors.affiliation: N. I. Pirogov Russian State Medical University, Ministry of Health Care and Sicial Development of the Russian Federation, Moscow, Russia. katekons@mail.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Konstantinova
authors.forename: N F
authors.initials: NF
authors.lastname: Khomyakova
authors.forename: N A
authors.initials: NA
authors.lastname: Konstantinova
authors.forename: A V
authors.initials: AV
authors.lastname: Podkolzina
authors.forename: A M
authors.initials: AM
authors.lastname: Sapozhnikov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D016022:Case-Control Studies; D005260:Female; D006360:Heat-Shock Proteins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D032383:Myocytes, Cardiac / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D006360:Heat-Shock Proteins