title: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome.
abstract: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a monogenic autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene and, as a syndrome, is characterized by chronic mucocutaneous candidiasis and the presentation of various autoimmune diseases. During the last decade, research on APECED and AIRE has provided immunologists with several invaluable lessons regarding tolerance and autoimmunity. This review describes the clinical and immunological features of APECED and discusses emerging alternative models to explain the pathogenesis of the disease.
authors.affiliation: Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia. kai.kisand@ut.ee
authors.forename: Kai
authors.initials: K
authors.lastname: Kisand
authors.forename: Pärt
authors.initials: P
authors.lastname: Peterson
mesh_terms: D015551:Autoimmunity / Q000235:genetics / Q000276:immunology; D002178:Candidiasis, Chronic Mucocutaneous / Q000235:genetics / Q000276:immunology; D005809:Genes, Regulator / Q000276:immunology; D006801:Humans; D009154:Mutation; D016884:Polyendocrinopathies, Autoimmune / Q000235:genetics* / Q000276:immunology / Q000378:metabolism