title: [Castleman disease].
abstract: BACKGROUND
  Castleman disease is a rare non-clonal lymphoproliferative disorder with the etiopathogenesis not yet thoroughly clarified. Clinically, either unicentric (localized) or multicentric (generalized) forms are recognized while, histopathologically, hyaline-vascular, plasma-cell and mixed variants of the disease exist. These types vary one from another in their clinical courses and, importantly, in methods of therapeutic management. While the unicentric hyaline-vascular form usually manifests as benign growth of a single lymph node and treatment response to complete surgical excision reaches up to 100%, the multicentric plasmocellular variant is an aggressive disease with generalized symptoms, laboratory abnormalities and the need for systemic therapy.
  
  
  OBJECTIVE
  The paper provides an overview of information on Castleman disease from its clinical and histopathological signs to diagnostic and therapeutic options. It deals with the role of cytokines and HHV-8 virus infection in the disease pathophysiology and is supplied with ample pictorial documentation of radiographic findings including ultrasonography, computed tomography and hybrid imaging by positron emission tomography (PET) in combination with simultaneously taken full-body computed tomography (CT) scans, the so called PET/CT. We also present photographs of histological specimens taken from an HIV and HHV-8 negative patient with the plasmocellular multicentric form.
  
  
  CONCLUSIONS
  Consequent to its low incidence, Castleman disease is often misdiagnosed or diagnosed with a delay. Therefore, it is always necessary to include this rare condition in differential diagnostics of lymphadenopathy, microcytic anemia as well as B-symptoms (night sweats, fevers and weight loss). In conclusion, we also stress the significance of full-body PET/CT scanning during staging and treatment response evaluation.
authors.affiliation: Interní hematoonkologická klinika, LF MU a FN Brno. petr.szturz@fnbrno.cz
authors.forename: P
authors.initials: P
authors.lastname: Szturz
authors.forename: M
authors.initials: M
authors.lastname: Moulis
authors.forename: Z
authors.initials: Z
authors.lastname: Adam
authors.forename: R
authors.initials: R
authors.lastname: Slaisová
authors.forename: R
authors.initials: R
authors.lastname: Koukalová
authors.forename: Z
authors.initials: Z
authors.lastname: Rehák
authors.forename: P
authors.initials: P
authors.lastname: Volfová
authors.forename: R
authors.initials: R
authors.lastname: Hájek
authors.forename: J
authors.initials: J
authors.lastname: Mayer
mesh_terms: D005871:Castleman Disease / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans