title: Relationship between advanced oxidation protein products, advanced glycation end products, and S-nitrosylated proteins with biological risk and MDR-1 polymorphisms in patients affected by B-chronic lymphocytic leukemia.
abstract: The aim of our study was to analyze the serum levels of advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEs), and protein nitrosylation in patients with B-chronic lymphocytic leukemia (B-CLL). AOPPs, AGEs, and S-nitrosylated were increased in B-CLL patients. The mutation of IgVH gene, CD 38, and Zap 70 expression were not associated with increased oxidative stress. The mutant 2677GT genotype was found to be associated with higher AGEs levels with respect to wild-type genotype, while as far the C3435T MDR1 polymorphism is concerned, subjects presenting wild-type genotype showed higher values of AOPPs with respect to heterozygous genotype. Our results suggest that B-CLL is associated with oxidative stress.
authors.affiliation: School and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, Messina, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Allegra
authors.forename: Mohamed
authors.initials: M
authors.lastname: Aguennouz
authors.forename: Andrea
authors.initials: A
authors.lastname: Alonci
authors.forename: Antonio
authors.initials: A
authors.lastname: Speciale
authors.forename: Antonino
authors.initials: A
authors.lastname: Cannavò
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Cristani
authors.forename: Sabina
authors.initials: S
authors.lastname: Russo
authors.forename: Giovanna
authors.initials: G
authors.lastname: Spatari
authors.forename: Angela
authors.initials: A
authors.lastname: Alibrandi
authors.forename: Caterina
authors.initials: C
authors.lastname: Musolino
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000097:blood / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism*; D008222:Lymphokines / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015538:Nitrosation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000097:blood / Q000235:genetics; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000097:blood / Q000235:genetics
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001798:Blood Proteins; C089422:Fv protein, human; D017127:Glycation End Products, Advanced; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D008222:Lymphokines; D011506:Proteins; D012795:Sialoglycoproteins; D051746:ZAP-70 Protein-Tyrosine Kinase; D051997:ADP-ribosyl Cyclase 1