title: When food meets man: the contribution of epigenetics to health.
abstract: Post-translational modifications of chromatin contribute to the epigenetic control of gene transcription. The response to food intake and individual nutrients also includes epigenetic events. Bile acids are necessary for lipid digestion and absorption, and more recently have emerged as signaling molecules. Their synthesis is transcriptionally regulated also in relation to the fasted-to-fed cycle, and interestingly, the underlying mechanisms include chromatin remodeling at promoters of key genes involved in their metabolism. Several compounds present in nutrients affect gene transcription through epigenetic mechanisms and recent studies demonstrate that, beyond the well known anti-cancer properties, they beneficially affect energy metabolism.
authors.affiliation: Giovanni Galli Laboratory of Biochemistry and Molecular Biology of Lipids and Mass Spectrometry, Department of Pharmacological Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy. emma.defabiani@unimi.it
authors.forename: Emma
authors.initials: E
authors.lastname: De Fabiani
authors.forename: Nico
authors.initials: N
authors.lastname: Mitro
authors.forename: Federica
authors.initials: F
authors.lastname: Gilardi
authors.forename: Andrea
authors.initials: A
authors.lastname: Galmozzi
authors.forename: Donatella
authors.initials: D
authors.lastname: Caruso
authors.forename: Maurizio
authors.initials: M
authors.lastname: Crestani
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D004734:Energy Metabolism / Q000502:physiology*; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics
chemical_list: D001647:Bile Acids and Salts; D002843:Chromatin; D006655:Histone Deacetylases