title: An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn.
abstract: A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N-alkylating agents in a hydrogen autotransfer process. 1,2,3,4-Tetrahydroquinolines and N-alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.
authors.affiliation: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot (Valencia), Spain. belen.abarca@uv.es
authors.forename: Belén
authors.initials: B
authors.lastname: Abarca
authors.forename: Rosa
authors.initials: R
authors.lastname: Adam
authors.forename: Rafael
authors.initials: R
authors.lastname: Ballesteros
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000438:Alcohols; D011804:Quinolines; D010165:Palladium; D002244:Carbon; D015032:Zinc