title: The antifungal constituents from the seeds of Itoa orientalis.
abstract: Three new phenolic constituents, itolide A (1), itolide B (2), itoside P (3), and 1D-3-deoxy-3-hydroxymethyl-myo-inositol (4), which is described herein for the first time as a natural product, were isolated along with four other known compounds (5 to 8) from the methanol extract of the seeds of Itoa orientalis Hemsl by the activity-guided fractionation. Their structures were determined by spectroscopic means. Compounds 1 to 8 exhibited antifungal activities against Sclerotium rolfsii with IC₅₀ values ranging from 60.12 to 240.00 μM and against Rhizoctonia solani with IC₅₀ values ranging from 45.34 to 233.14 μM, respectively, and compounds 1, 2, 5 exhibited cytotoxic activity against Tn5B1-4 insect cell line with EC₅₀ values of 203.68, 93.41 and 40.37 μM, respectively.
authors.affiliation: Institute of Pesticide and Environmental Toxicology, Guangxi University, Nanning 530004, People's Republic of China.
authors.forename: WenWei
authors.initials: W
authors.lastname: Tang
authors.forename: HanHong
authors.initials: H
authors.lastname: Xu
authors.forename: DongQiang
authors.initials: D
authors.lastname: Zeng
authors.forename: LiJia
authors.initials: L
authors.lastname: Yu
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000302:isolation & purification / Q000494:pharmacology*; D007294:Inositol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D007313:Insecta; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects; D031308:Salicaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: C493876:1D-3-deoxy-3-hydroxymethyl-myo-inositol; D000935:Antifungal Agents; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D010636:Phenols; D010936:Plant Extracts; C574357:itolide A; C574358:itolide B; C574359:itoside P; D007294:Inositol