title: Helicobacter pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke.
abstract: BACKGROUND
  Helicobacter pylori (H. pylori) infection has been associated with atherosclerosis of coronary arteries but there is lack of data regarding possible association between chronic H. Pylori infection and cerebral non-cardioembolic ischemia. We evaluated H. pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke.
  
  
  METHODS
  This was a cross-sectional study carried out in Alzahra hospital, Isfahan, Iran. 96 patients with ischemic stroke were enrolled in this study. Control group were selected from healthy blood donors. IgG and IgA antibodies to H. pylori were detected using a rapid enzyme linked immunosorbent assay. Quantitative variables and categorical variables were compared using t student and chi-square tests.
  
  
  RESULTS
  There were 21 cases of hypertension and 5 cases of diabetes mellitus among patients. Patients and controls were similar regarding serum IgA and IgG titers as well as positivity. There were 13 and 15 cases of positive IgA and 44 and 39 cases of positive IgG among patients and controls, respectively. Also, there were 7 and 9 cases of both positive IgA and IgG in patients and controls, respectively. No differences were found between the two groups in IgA or IgG titers or positivity (p > 0.05).
  
  
  CONCLUSIONS
  Patients with stroke were not different regarding either H. Pylori IgA or IgG positivity or the antibody titers. Comparing genetic typing of H. pylori in patients with or without stroke and diagnosis of H. pylori with more specific and sensitive tests such as stool antigen test are recommended.
authors.affiliation: Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Mousavi
authors.forename: Behrooz
authors.initials: B
authors.lastname: Ataei
authors.forename: Iraj
authors.initials: I
authors.lastname: Karimi
authors.forename: Kamyar
authors.initials: K
authors.lastname: Ashrafi