title: Improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed klinefelter syndrome.
abstract: Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism. The majority (80-90%) of patients have 47, XXY karyotype while mosaicism is seen in only 10-20% of patients. Leg ulcers may be a presenting symptom of KS with a prevalence of 6-13%. Treatment with testosterone has been reported to improve the ulcers.
authors.affiliation: Division of Endocrinology; Department of Internal Medicine; University of Texas; Southwestern Residency Programs at Seton Family of Hospitals; Austin, TX USA.
authors.forename: Shwetha
authors.initials: S
authors.lastname: Thukuntla
authors.forename: Pratima
authors.initials: P
authors.lastname: Kumar