title: The prognostic significance of the immunohistochemical expression of P53 and BCL-2 in endometrial cancer.
abstract: The objective of this study was to verify the frequency of P53 and BCL-2 immunohistochemical expression in 98 patients with endometrial carcinoma, and to correlate it with clinical stage and patient survival. A significant difference was found regarding the frequency of P53 expression when comparing type I and II tumors (23.7% and 54.5%, respectively; p = 0.006). A positive correlation was observed between P53 immunoexpression and patient survival in type I and II tumors (p = 0.009 and p = 0.036, respectively). BCL-2 expression was significantly more frequent in early clinical stages in both types of endometrial cancer (p 〈 0.001 and 0.002) and correlated with a decrease in overall survival in type I endometrial cancer (p = 0.014). Thus, the prognostic value of these biomarkers in endometrial cancer needs to be further investigated.
authors.affiliation: Department of Obstetrics, Gynecology and Obstetrics/Gynecological Care, Medical University of Bialystok, Poland. bdobrzycka@gmail.com
authors.forename: Bozena
authors.initials: B
authors.lastname: Dobrzycka
authors.forename: Slawomir J
authors.initials: SJ
authors.lastname: Terlikowski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Garbowicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Niklinski
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
authors.forename: Marek
authors.initials: M
authors.lastname: Kulikowski
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53