title: Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design.
abstract: Recent trials of statins produced no benefit for subjects with Alzheimer's disease. These negative studies add to a growing list of negative clinical trials. These data point to a need for reevaluating the pathophysiology of late-onset Alzheimer's disease. Late-onset Alzheimer's disease might result from the cumulative effects of at least four different factors: β-amyloid accumulation, cardiovascular disease, aging and the associated loss of synaptic plasticity, and inflammation. Successful therapy of subjects with overt dementia might require approaches targeting all four pathophysiological domains.
authors.affiliation: Departments of Pharmacology and Neurology, Boston University School of Medicine, 715 Albany Street, Room R614, Boston, MA 02118-2526, USA. bwolozin@bu.edu.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wolozin