title: Complex apocrine carcinoma with dominant myoepithelial proliferation in a dog.
abstract: A rare case of complex apocrine carcinoma displaying dominant myoepithelial proliferation developed in the right leg subcutis of a 10-year-old male dog. The major cell population consisted of diffusely proliferating p63-expressing neoplastic cells that were largely myoepithelial in origin co-expressing α-smooth muscle actin. A small portion of the cell population consisted of concomitant basal epithelial cells lacking α-smooth muscle actin expression. The minor population consisted of p63-negative apocrine gland cells that expressed cytokeratin 8. The myoepithelial cell population showed a rather stronger proliferation activity than did the apocrine epithelial population. Thus, this tumor might have been derived from basal epithelial cells characterized by more predominant myoepithelial differentiation than luminal apocrine epithelial differentiation.
authors.affiliation: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Shiraki
authors.forename: Yuri
authors.initials: Y
authors.lastname: Hojo
authors.forename: Takuma
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Liyun
authors.initials: L
authors.lastname: Wang
authors.forename: Takumi
authors.initials: T
authors.lastname: Ohishi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Mitsumori
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibutani
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D053533:Keratin-8 / Q000378:metabolism; D008297:Male; D009208:Myoepithelioma / Q000473:pathology / Q000662:veterinary*; D013544:Sweat Gland Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D000199:Actins; D053533:Keratin-8