title: Cysteine 38 holds the key to NF-κB activation.
abstract: The importance of parallel signaling pathways controlling NF-κB subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that RelA (p65) sulfhydration, at its highly conserved cysteine 38 residue, regulates association with the coactivator RPS3, DNA binding, and antiapoptotic gene expression.
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Catherine Cookson Building, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK. neil.perkins@ncl.ac.uk
authors.forename: Neil D
authors.initials: ND
authors.lastname: Perkins