title: Functional interferon system is required for clearance of lassa virus.
abstract: Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.
authors.affiliation: Galveston National Laboratory, Institute for Human Infectious and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. neyun@utmb.edu
authors.forename: Nadezhda E
authors.initials: NE
authors.lastname: Yun
authors.forename: Allison L
authors.initials: AL
authors.lastname: Poussard
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Seregin
authors.forename: Aida G
authors.initials: AG
authors.lastname: Walker
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Smith
authors.forename: Judith F
authors.initials: JF
authors.lastname: Aronson
authors.forename: Jeanon N
authors.initials: JN
authors.lastname: Smith
authors.forename: Lynn
authors.initials: L
authors.lastname: Soong
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007372:Interferons / Q000276:immunology*; D007835:Lassa Fever / Q000276:immunology* / Q000821:virology; D007836:Lassa virus / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D017471:Receptors, Interferon / Q000235:genetics / Q000276:immunology
chemical_list: D017471:Receptors, Interferon; D007372:Interferons