title: Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.
abstract: Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
authors.forename: Kok-Chuan
authors.initials: KC
authors.lastname: Tiew
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Dou
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Teramoto
authors.forename: Huiguo
authors.initials: H
authors.lastname: Lai
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Alliston
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: R
authors.initials: R
authors.lastname: Padmanabhan
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D057930:Click Chemistry; D003715:Dengue / Q000188:drug therapy / Q000201:enzymology; D003716:Dengue Virus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D008958:Models, Molecular; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D014901:West Nile Fever / Q000188:drug therapy / Q000201:enzymology; D014902:West Nile virus / Q000187:drug effects / Q000201:enzymology*
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D013844:Thiazoles; D010447:Peptide Hydrolases