title: Postoperative complications of conjunctival limbal autograft surgery.
abstract: OBJECTIVE
  To report postoperative complications of conjunctival limbal autograft in patients with unilateral total limbal stem cell deficiency (LSCD).
  
  
  METHODS
  In this retrospective observational case series, medical charts of 34 patients with unilateral total LSCD with at least 6 months of follow-up were reviewed. Main outcome measure was postoperative complications.
  
  
  RESULTS
  The mean follow-up period was 17.2 ± 6.3 (range, 6-33) months. The postoperative complications observed included conjunctival encroachment over the graft, small graft, graft dislodging, thick graft, improper position, graft edema, ocular surface exposure, progressive horizontal conjunctivalization, and pyogenic granuloma. Persistent epithelial defect occurred in 5 eyes because of ocular surface exposure (n = 2), conjunctival encroachment (n = 1), and small graft size (n = 2). Epithelial defects healed in 4 of them with sectoral vascularization of the cornea. Optical penetrating keratoplasty was performed on 18 eyes with dense corneal opacification. Persistent epithelial defect occurred in 6 eyes with inadvertent cut limbal graft (n = 2), small limbal graft (n = 2), and ocular surface exposure (n = 2).
  
  
  CONCLUSIONS
  Conjunctival limbal autograft is an effective procedure for anatomical and visual rehabilitation of eyes with unilateral total LSCD. However, it may be complicated by several adverse events. The most common complications are related to the transplanted grafts (size, thickness, position, and alignment) and chronic ocular surface exposure, which may later lead to epithelial breakdown and corneal conjunctivalization.
authors.affiliation: Ophthalmic Research Center, Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Baradaran-Rafii
authors.forename: Medi
authors.initials: M
authors.lastname: Eslani
authors.forename: Hossein
authors.initials: H
authors.lastname: Jamali
authors.forename: Farid
authors.initials: F
authors.lastname: Karimian
authors.forename: Urvi A
authors.initials: UA
authors.lastname: Tailor
authors.forename: Ali R
authors.initials: AR
authors.lastname: Djalilian
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003228:Conjunctiva / Q000166:cytology*; D003316:Corneal Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004847:Epithelial Cells / Q000637:transplantation; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology; D014182:Transplantation, Autologous; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult