title: Prevalence of celiac disease among first-degree relatives of patients with celiac disease.
abstract: OBJECTIVE
  Celiac disease, an autoimmune enteropathy that affects the proximal small intestine, is characteristically seen in people who have a genetic susceptibility to gluten sensitivity. Celiac patients' first-degree relatives are more at risk of acquiring the disease. The objective of the present study was consequently to determine the prevalence of celiac disease in a group of first-degree relatives of our patients with celiac disease.
  
  
  METHODS
  First-degree relatives of 195 patients with celiac disease attending a gastroenterology unit underwent serologic screening. Antitissue transglutaminase (anti-tTG) immunoglobulin A (IgA) and total serum IgA tests were used for first-level screening. Duodenal biopsy was recommended to subjects showing positive results to anti-tTG IgA testing. Biopsy samples were obtained by endoscopy, and biopsy specimens were evaluated and classified according to Marsh classification.
  
  
  RESULTS
  Positive anti-tTG IgA was found in 46 first-degree relatives (9.5%), whereas serum IgA levels were normal. Of 46 serology-positive relatives, 34 agreed to the endoscopy procedure. Histological changes characteristic of celiac disease were found in 23 subjects. The prevalence of celiac disease among the first-degree relatives was found to be at least 4.8%. Of 34 subjects that underwent biopsy, 11 were evaluated as Marsh 0, 5 as Marsh 1, 4 as Marsh 2, 12 as Marsh 3, and 2 as Marsh 4. Of the biopsy-positive subjects, 3 were mothers, 1 was a father, and 19 were siblings.
  
  
  CONCLUSIONS
  The present study identified 23 undiagnosed cases of celiac disease among 484 first-degree relatives of 195 patients with celiac disease, confirming the high prevalence (4.8%) of the disease in this specific group. It is suggested that an extensive screening policy be mandatory for these subjects.
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology and Nutrition, Fırat Medical Faculty, Firat University, Elaziğ, Turkey. yasardogan@ttmail.com
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Doğan
authors.forename: Serap
authors.initials: S
authors.lastname: Yildirmaz
authors.forename: Ibrahim Hanifi
authors.initials: IH
authors.lastname: Ozercan
mesh_terms: D001323:Autoantibodies / Q000097:blood / Q000235:genetics*; D001706:Biopsy; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D004724:Endoscopy; D005220:Fathers; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D009035:Mothers; D009679:Nuclear Family; D015995:Prevalence; D035781:Siblings; D011503:Transglutaminases / Q000235:genetics / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D011503:Transglutaminases