title: Wilms tumor: recent advances in clinical care and biology.
abstract: Wilms tumor is the most common renal malignancy that occurs in childhood. The remarkable evolution of treatment for this malignancy has served as a paradigm for multimodal cancer treatment. A rich database has accrued over time from well-controlled clinical trials. Translational research has directly affected patient care by allowing risk-based therapy. This article will summarize advances in our knowledge of the biology of Wilms tumor and describe the impact on clinical treatment of Wilms tumor.
authors.affiliation: Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. thomas.hamilton@childrens.harvard.edu
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Hamilton
authors.forename: Robert C
authors.initials: RC
authors.lastname: Shamberger
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D009367:Neoplasm Staging / Q000639:trends; D012306:Risk; D057170:Translational Research, Biomedical / Q000639:trends; D009396:Wilms Tumor / Q000473:pathology* / Q000601:surgery / Q000628:therapy*