title: Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines.
abstract: An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Zengjun
authors.initials: Z
authors.lastname: Guo
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Wenming
authors.initials: W
authors.lastname: Xu
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Han
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D031804:Rumex / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: C571659:6-methyl-7-acetyl-1,8-dihydroxy naphthalene-1-O-beta-D(L)-glucoside; C571658:6-methyl-7-acetyl-1,8-dihydroxy-3-methoxy naphthalene-1-O-beta-D(L)-glucoside; D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D009281:Naphthalenes; C027113:chrysophanic acid