title: Vitamin D status during pregnancy and aspects of offspring health.
abstract: Low maternal vitamin D levels during pregnancy have been linked to various health outcomes in the offspring, ranging from periconceptional effects to diseases of adult onset. Maternal and infant cord 25(OH)D levels are highly correlated. Here, we review the available evidence for these adverse health effects. Most of the evidence has arisen from observational epidemiological studies, but randomized controlled trials are now underway. The evidence to date supports that women should be monitored and treated for vitamin D deficiency during pregnancy but optimal and upper limit serum 25(OH)D levels during pregnancy are not known.
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, Australia. anne-louise.ponsonby@mcri.edu.au
authors.forename: Anne-Louise
authors.initials: AL
authors.lastname: Ponsonby
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Lucas
authors.forename: Sharon
authors.initials: S
authors.lastname: Lewis
authors.forename: Jane
authors.initials: J
authors.lastname: Halliday
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000209:etiology*; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology
chemical_list: D014807:Vitamin D