title: Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry.
abstract: We describe complexation reactions of insulin and other proteins with metal ions generated from the substrate surface by laser irradiation in laser desorption spray post-ionization mass spectrometry (LDSPI-MS). This particular type of complexation reaction in LDSPI-MS was investigated for the first time, which indicated that the mechanistic process of LDSPI-MS might be much more complicated than that proposed before for similar methods.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Chengsen
authors.initials: C
authors.lastname: Zhang
authors.forename: Jiamu
authors.initials: J
authors.lastname: Sun
authors.forename: Hai
authors.initials: H
authors.lastname: Luo
mesh_terms: D007328:Insulin / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D011506:Proteins / Q000032:analysis / Q000737:chemistry*
chemical_list: D007328:Insulin; D011506:Proteins