title: Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease.
abstract: Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown. In this study the association of the AD clusterin common risk polymorphism rs9331888 with blood clusterin levels was tested in 104 AD subjects and 104 healthy controls. Blood clusterin levels were significantly elevated in AD patients (p < 0.05). The rs9331888 AD-risk variant was associated with low clusterin mRNA and protein levels in an allele-dose dependent manner in both groups (p < 0.001). This study indicates that the rs9331888 AD-risk variant is associated with low blood clusterin levels.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Xing
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Cui
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Zhong
authors.forename: Zhong-Chen
authors.initials: ZC
authors.lastname: Wu
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D000704:Analysis of Variance; D051152:Clusterin / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000378:metabolism; D012307:Risk Factors
chemical_list: D051152:Clusterin; D012333:RNA, Messenger