title: Cardiac effects of HDL and its components on diabetic cardiomyopathy.
abstract: Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus, but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+ handling, glucose homeostasis, and endothelial dysfunction.
authors.affiliation: Department of Cardiology and Pneumology, Charité, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Spillmann
authors.forename: Sophie
authors.initials: S
authors.lastname: Van Linthout
authors.forename: Carsten
authors.initials: C
authors.lastname: Tschöpe
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D050171:Dyslipidemias / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D006946:Hyperinsulinism / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D000975:Antioxidants; D008075:Lipoproteins, HDL; D002118:Calcium