title: [Delayed haemolytic transfusion reaction due to anti-JK1 antibody].
abstract: BACKGROUND
  The sensitivity of the detection of irregular antibodies (DIA) is one of the fundamental basis of transfusion safety. The production of alloantibodies is the first cause of adverse events following transfusion.
  
  
  METHODS
  We report a 77-year-old woman who was transfused and presented with a delayed haemolytic anemia due to anti-JK1 alloimmunization. This event highlights the limits of DIA performed before a transfusion, the hazard of this specific type of antibody and the difficulties of the diagnosis of haemolytic anaemia. The preventive measures necessary to avoid this undesirable effect are reminded.
  
  
  CONCLUSIONS
  Despite the sensitive routine test method, the anti-JK1 antibodies could be missed. We should keep in mind the possibility of an anaemia due to alloantibodies we confronted to an unexplained haemolytic episode.
authors.affiliation: Service de médecine interne oncologie, hôpital Desgenettes, 108 boulevard Pinel, Lyon, France. f.decharry@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: de Charry
authors.forename: C
authors.initials: C
authors.lastname: de Charry
authors.forename: P
authors.initials: P
authors.lastname: Gérôme
authors.forename: M
authors.initials: M
authors.lastname: Pavic
authors.forename: Q
authors.initials: Q
authors.lastname: Lacoin
authors.forename: F
authors.initials: F
authors.lastname: Pasquet
authors.forename: P
authors.initials: P
authors.lastname: Debourdeau
mesh_terms: D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000150:complications / Q000276:immunology / Q000628:therapy*; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology* / Q000502:physiology; D001787:Blood Group Incompatibility / Q000150:complications* / Q000175:diagnosis; D057210:Delayed Diagnosis; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology* / Q000502:physiology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007518:Isoantibodies