title: Vascular endothelial growth factor and its receptors in the placenta of pregnant women with obesity.
abstract: Comparative morphological study of placentas from women with obesity and normal body weight was performed. Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was detected by immunohistochemical methods. Nonbranching angiogenesis predominated in the placentas from obese women. Immunohistochemical analysis showed reduced intensity of the reaction to VEGF in the syncytiotrophoblast and vascular endothelium of stem villi and enhanced VEGF expression in non-villous cytotrophoblast and endothelial cells of capillaries of mature intermediate and terminal villi; reduced expression of VEGFR-1 and increased levels of VEGFR-2 and VEGFR-3 in the studied structures were also noted.
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Moscow, Russia. dubovaea@gmail.com
authors.forename: E A
authors.initials: EA
authors.lastname: Dubova
authors.forename: K A
authors.initials: KA
authors.lastname: Pavlov
authors.forename: E I
authors.initials: EI
authors.lastname: Borovkova
authors.forename: M A
authors.initials: MA
authors.lastname: Bayramova
authors.forename: I O
authors.initials: IO
authors.lastname: Makarov
authors.forename: A I
authors.initials: AI
authors.lastname: Shchegolev
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor