title: The Association between Parathyroid Hormone Levels and the Cardiorenal Metabolic Syndrome in Non-Diabetic Chronic Kidney Disease.
abstract: OBJECTIVE
  The relationship between parathyroid hormone (PTH) and the cardiorenal metabolic syndrome was examined among non-diabetic persons with chronic kidney disease (CKD).
  
  
  METHODS
  In a cross-sectional analysis, the relationship between PTH levels and the cardiorenal metabolic syndrome was investigated in 3,215 non-diabetic participants in the National Kidney Foundation-Kidney Early Evaluation Program (KEEP 2.0) found to have CKD (eGFR <60 ml/min/1.73 m2).
  
  
  RESULTS
  In unadjusted analyses, the prevalence of the cardiorenal metabolic syndrome increased along increasing PTH quartiles (31.7, 33.8, 37.3, and 48.7%, respectively, p for trend <0.0001). After multivariate adjustment, as compared to the first PTH quartile, odds of the cardiorenal metabolic syndrome were 16% (p = 0.18), 35% (p = 0.006), and 80% (p < 0.0001) higher for the second, third, and fourth quartiles, respectively. When taken as a continuous predictor, each standard deviation increase of natural log transformed PTH was associated with 26% (p < 0.0001) higher odds of the cardiorenal metabolic syndrome. The association of PTH with the cardiorenal metabolic syndrome was not modified by age or gender (p for interaction was not significant for both modifiers).
  
  
  CONCLUSIONS
  Among an outpatient non-diabetic population with CKD, higher PTH levels were associated with a higher prevalence of the cardiorenal metabolic syndrome.
authors.forename: Georges
authors.initials: G
authors.lastname: Saab
authors.forename: Adam
authors.initials: A
authors.lastname: Whaley-Connell
authors.forename: Andrew
authors.initials: A
authors.lastname: Bombeck
authors.forename: Manjula
authors.initials: M
authors.lastname: Kurella Tamura
authors.forename: Suying
authors.initials: S
authors.lastname: Li
authors.forename: Shu-Cheng
authors.initials: SC
authors.lastname: Chen
authors.forename: Samy I
authors.initials: SI
authors.lastname: McFarlane
authors.forename: James R
authors.initials: JR
authors.lastname: Sowers
authors.forename: Keith
authors.initials: K
authors.lastname: Norris
authors.forename: George L
authors.initials: GL
authors.lastname: Bakris
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough