title: Hypoglycemia detection based on cardiac repolarization features.
abstract: Hypoglycemia is known to affect repolarization characteristics of the heart. These changes are shown from ECG by prolonged QT-time and T-wave flattening. In this study we constructed a classifier based on these ECG parameters. By using the classifier we tried to detect hypoglycemic events from measurements of 22 test subjects. Hypoglycemic state was achieved using glucose clamp technique. Used test protocol consisted of three stages: normoglycemic period, transition period (blood glucose concentration decreasing) and hypoglycemic period. Subjects were divided into three groups: 9 healthy controls (Healthy), 6 otherwise healthy type 1 diabetics (T1DM) and 7 type 1 diabetics with disease complications (T1DMc). Detection of hypoglycemic event could be made passably from 15/22 measurements. In addition, we found that detection process is easier for healthy and T1DM groups than T1DMc group diabetics because in T1DMc group subjects' have lower autonomic response to hypoglycemic events. Also we noticed that changes in ECG occurs few minutes after blood glucose is decreased below 3.5 mmol/1.
authors.affiliation: Department of Applied Physics, University of Eastern Finland, Kuopio, Finland. jukka.lipponen@uef.fi
authors.forename: J A
authors.initials: JA
authors.lastname: Lipponen
authors.forename: J
authors.initials: J
authors.lastname: Kemppainen
authors.forename: P A
authors.initials: PA
authors.lastname: Karjalainen
authors.forename: T
authors.initials: T
authors.lastname: Laitinen
authors.forename: H
authors.initials: H
authors.lastname: Mikola
authors.forename: T
authors.initials: T
authors.lastname: Kärki
authors.forename: M P
authors.initials: MP
authors.lastname: Tarvainen
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D004562:Electrocardiography / Q000379:methods; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000503:physiopathology; D018408:Patch-Clamp Techniques