title: Uveodermatologic lymphoma in two young related Portuguese water dogs.
abstract: OBJECTIVE
  Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin's and Hodgkin's lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed.
  
  
  METHODS
  A 1-year-old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work-up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200 km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained.
  
  
  RESULTS
  The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2.
  
  
  CONCLUSIONS
  It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.
authors.affiliation: Servei d'Oftalmologia Veterinària, Fundació Hospital Clínic Veterinari, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Campus de la UAB, Edifici V. 08193. Bellaterra, Barcelona, Spain.
authors.forename: Natàlia
authors.initials: N
authors.lastname: Escanilla
authors.forename: Marta
authors.initials: M
authors.lastname: Leiva
authors.forename: Laura
authors.initials: L
authors.lastname: Ordeix
authors.forename: Teresa
authors.initials: T
authors.lastname: Peña
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D008223:Lymphoma / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D014604:Uveal Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*