title: Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer.
abstract: The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2)  daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University School of Veterinary Medicine, West Lafayette, IN, USA.
authors.forename: T N
authors.initials: TN
authors.lastname: Leach
authors.forename: M O
authors.initials: MO
authors.lastname: Childress
authors.forename: S N
authors.initials: SN
authors.lastname: Greene
authors.forename: A S
authors.initials: AS
authors.lastname: Mohamed
authors.forename: G E
authors.initials: GE
authors.lastname: Moore
authors.forename: D R
authors.initials: DR
authors.lastname: Schrempp
authors.forename: S R
authors.initials: SR
authors.lastname: Lahrman
authors.forename: D W
authors.initials: DW
authors.lastname: Knapp
mesh_terms: D059250:Administration, Metronomic; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D011446:Prospective Studies
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil