title: Acute toxicity studies of safer and more effective analogues of N,N-diethyl-2-phenylacetamide.
abstract: The present work was designed to evaluate the toxicity of various synthesized aromatic amides that are analogs of N,N-diethyl-2-phenylacetamide, a well known insect repellent. The toxicity profile of these compounds was compared with N,N-diethyl-2-phenylacetamide as well as other registered insect repellents namely N,N-diethyl-3-methyl benzamide and N,N-diethylbenzamide. The primary skin irritation index values of the compounds, dermal toxicity of the chemicals and acute oral toxicity data to assess the safety of the synthesized aromatic amides are reported in this paper. Results of hematological and biochemical studies of these analogues are reported and discussed.
authors.affiliation: Defence Research and Development Establishment (DRDE), Jhansi Road, Gwalior (M.P.), India. akanksha.garud@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Garud
authors.forename: Anshoo
authors.initials: A
authors.lastname: Gautam
authors.forename: K
authors.initials: K
authors.lastname: Ganesan
authors.forename: Pravin
authors.initials: P
authors.lastname: Kumar
authors.forename: Shri
authors.initials: S
authors.lastname: Prakash
authors.forename: P C
authors.initials: PC
authors.lastname: Jatav
authors.forename: Abdesh
authors.initials: A
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Vijayaraghavan
mesh_terms: D000083:Acetanilides / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D007302:Insect Repellents / Q000737:chemistry / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D000083:Acetanilides; D007302:Insect Repellents; C044250:N,N-diethylphenylacetamide