title: A low-power high-sensitivity CMOS mixed-signal seizure-onset detector.
abstract: In this paper, we present a new seizure detection algorithm and the associated CMOS circuitry implementation. The proposed low-power seizure detector is a good candidate for an implantable epilepsy prosthesis. The device is designed for patient-specific seizure detection with a one variable parameter. The parameter value is extracted from a single seizure that is subsequently excluded from the validation phase. A two-path system is also proposed to minimize the detection delay. The algorithm is first validated using MATLAB® tools and then implemented and validated using circuits designed in a standard 0.18-μm CMOS process with a total power dissipation of 7.08 μW. A total of 13 seizures from two drug-resistant epileptic patients are assessed using the proposed algorithm and resulted in 100% sensitivity and a mean detection delay of 9.7 s after electrical onset.
authors.affiliation: Polystim Neurotechnologies Laboratory, École Polytechnique de Montréal, Montréal, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Safi-Harb
authors.forename: M Tariqus
authors.initials: MT
authors.lastname: Salam
authors.forename: S
authors.initials: S
authors.lastname: Mirabbasi
authors.forename: D K
authors.initials: DK
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Sawan
mesh_terms: D000328:Adult; D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation*; D011211:Electric Power Supplies; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D015203:Reproducibility of Results; D012640:Seizures / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D014173:Transistors, Electronic; D055815:Young Adult