title: Radiolabeled glucagon-like peptide-1 analogues:  a new pancreatic β-cell imaging agent.
abstract: Glucagon-like peptide-1 (GLP-1) is a potent antihyperglycemic hormone. It can induce glucose-dependent insulin secretion. GLP-1 has a short half-life of less than 2 min in vivo due to degradation by the dipeptidyl peptidase-IV. GLP-l analogues, such as exendin-4 and exendin-3, have similar biological activity but a longer in-vivo half-life. Pancreatic β-cells and pancreatic islet cell tumors highly express GLP-1 receptors. Hence, radiolabeled GLP-1 analogues play a potential role in imaging and radiation therapy of pancreatic islet cell tumors as well as in the monitoring of pancreatic β-cell transplantation.
authors.affiliation: aDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangyifan1992@yahoo.com.cn
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wengen
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000627:therapeutic use; D006801:Humans; D050417:Insulin-Secreting Cells / Q000000981:diagnostic imaging; D007340:Insulinoma / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D008297:Male; D051379:Mice; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D049268:Positron-Emission Tomography / Q000379:methods; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D052216:Glucagon-Like Peptide 1