title: Does hormone replacement therapy have beneficial effects on renal functions in menopausal women?
abstract: BACKGROUND
  The study was carried out to evaluate the possible effects of hormone replacement therapy (HRT) on renal functions in postmenopausal women.
  
  
  METHODS
  A total of 85 postmenopausal women without a history of medical illness were enrolled in the study. They were divided into HRT users and control groups. After 30 weeks of HRT use, the changes in serum urea, creatinine, uric acid, urinary protein, urinary creatinine, urinary protein/creatinine ratio and glomerular filtration rate (GFR) (mL/min/1.73 m(2)) were evaluated.
  
  
  RESULTS
  HRT was associated with statistically significant increases in glomerular filtration rate (p < 0.01), while serum urea, creatinine, uric acid, urinary protein, urinary creatinine and urinary protein/creatinine ratio did not change significantly in both groups.
  
  
  CONCLUSIONS
  In our study, we suggested that usage of hormone replacement therapy appeared to affect renal functions in postmenopausal women. There were beneficial effects of HRT on GFR in our postmenopausal patients. HRT may have possible protective mechanisms for kidney against adverse effects of aging.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Medical School, Ciftlik Cad. No:57, Emek, 06510 Ankara, Turkey.
authors.forename: Ikbal
authors.initials: I
authors.lastname: Kaygusuz
authors.forename: Ilknur Inegol
authors.initials: II
authors.lastname: Gumus
authors.forename: Hilal Uslu
authors.initials: HU
authors.lastname: Yuvaci
authors.forename: Benan
authors.initials: B
authors.lastname: Kasapoğlu
authors.forename: Ayse
authors.initials: A
authors.lastname: Carlioglu
mesh_terms: D003404:Creatinine / Q000097:blood / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D020249:Hormone Replacement Therapy; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects* / Q000502:physiology; D011507:Proteinuria / Q000188:drug therapy; D014508:Urea / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000652:urine
chemical_list: D014527:Uric Acid; D014508:Urea; D003404:Creatinine