title: [Tranexamic acid reduces blood loss after major elective orthopaedic operations].
abstract: Anaemia in surgical patients has been proven to increase morbidity and mortality. Due to the risk of adverse effects and the cost of blood transfusions it is important to reduce the need for transfusions by pre- and intra-operative interventions. Tranexamic acid has long been used in orthopaedic surgery as an antifibrinolytic agent. Several studies within the orthopaedic fields have underlined the effect of the drug in reducing blood loss and need for transfusions. However, more studies are needed to examine the optimal dosage and administration along with the risks associated with the drug.
authors.affiliation: Ortopædkirurgisk Afdeling, Hvidovre Hospital, Denmark. c.s@dadlnet.dk
authors.forename: Camilla Tofte
authors.initials: CT
authors.lastname: Eschen
authors.forename: Peter Toft
authors.initials: PT
authors.lastname: Tengberg
authors.forename: Henrik
authors.initials: H
authors.lastname: Husted
authors.forename: Anders
authors.initials: A
authors.lastname: Troelsen
mesh_terms: D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D017558:Elective Surgical Procedures / Q000009:adverse effects / Q000379:methods; D006801:Humans; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000379:methods; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid