title: Synthesis, structure, and biological activity of novel (oxdi/tri)azoles derivatives containing 1,2,3-thiadiazole or methyl moiety.
abstract: To develop novel inhibitors of ketol-acid reductoisomerase, a series of (oxdi/tri)azoles derivatives was synthesized and characterized by (1)H  NMR, MS, elemental analyses, and crystallography. According to the biological activities of these compounds obtained both in vivo and in vitro, compound 4-cyclopropyl-3-((4-fluorobenzyl)thio)-5-methyl-4H-1,2,4-triazole showed excellent KARI inhibitory activity (100% at 100 μg mL (-1)  in vitro). In addition, most of the title compounds exhibited good herbicidal activity against Brassica campestris in vivo.
authors.affiliation: College of Chemical Engineering & Materials Sciences, Zhejiang University of Technology, Hangzhou, China. nkulxh@gmail.com
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Weng
authors.forename: Cheng-Xia
authors.initials: CX
authors.lastname: Tan
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Li
authors.forename: Bao-Lei
authors.initials: BL
authors.lastname: Wang
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Li
mesh_terms: D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001937:Brassica / Q000187:drug effects / Q000254:growth & development; D031747:Echinochloa / Q000187:drug effects / Q000254:growth & development; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006540:Herbicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D050540:Ketol-Acid Reductoisomerase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development
chemical_list: D001393:Azoles; D004791:Enzyme Inhibitors; D006540:Herbicides; D050540:Ketol-Acid Reductoisomerase