title: Visualisation of liver tumours using hand-held real-time strain imaging: results of animal experiments.
abstract: OBJECTIVE
  Surgical resection is the only curative option for colorectal hepatic metastases. Intra-operative localisation of these metastases during hepatic resection is performed by intra-operative B-mode imaging and palpation. Because liver metastases are stiffer than normal tissues, elastography may be a useful complement to B-mode imaging. This paper reports quantitative measures of the image quality attained during intra-operative real-time elastographic visualisation of liver metastasis.
  
  
  METHODS
  VX2 tumours were implanted in the liver of eight rabbits and were scanned in vivo. Measurements of the tumour dimensions obtained via elastography were compared with those obtained using B-mode imaging and with gross pathology.
  
  
  RESULTS
  Measurements of tumour diameters were similar when obtained by intra-operative elastography and pathological measurement methods (mean difference±standard deviation, 0.1±0.9 mm). The contrast between tumours and normal tissues was significantly higher (p<0.05) in elastograms (26±10 dB contrast) than in sonograms (1±1 dB contrast). Sensitivity and specificity for detecting tumours using intra-operative elastography were 100% and 88%, respectively, and positive and negative predictive values were 89% and 100%, respectively. In two cases elastograms were able to detect a tumour that was ambiguous in B-mode images.
  
  
  CONCLUSIONS
  Combined hand-held B-mode/strain imaging may provide additional information that is relevant for detection of liver metastases that may be missed by standard B-mode imaging alone, such as small and/or isoechoic tumours.
authors.affiliation: Inserm, U1032, Lyon, France. David.Melodelima@inserm.fr
authors.forename: D
authors.initials: D
authors.lastname: Melodelima
authors.forename: J
authors.initials: J
authors.lastname: Chenot
authors.forename: R
authors.initials: R
authors.lastname: Souchon
authors.forename: M
authors.initials: M
authors.lastname: Rivoire
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chapelon
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003199:Computer Systems; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008904:Miniaturization; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity