title: Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.
abstract: In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3%  in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.
authors.affiliation: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Pierre-Audigier
authors.forename: C
authors.initials: C
authors.lastname: Surcouf
authors.forename: V
authors.initials: V
authors.lastname: Cadet-Daniel
authors.forename: A
authors.initials: A
authors.lastname: Namouchi
authors.forename: S
authors.initials: S
authors.lastname: Heng
authors.forename: A
authors.initials: A
authors.lastname: Murray
authors.forename: B
authors.initials: B
authors.lastname: Guillard
authors.forename: B
authors.initials: B
authors.lastname: Gicquel
mesh_terms: D000581:Amidohydrolases / Q000235:genetics*; D000995:Antitubercular Agents / Q000627:therapeutic use; D002160:Cambodia / Q000453:epidemiology; D004269:DNA, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D015994:Incidence; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D011718:Pyrazinamide / Q000627:therapeutic use*; D012189:Retrospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D011718:Pyrazinamide; D000581:Amidohydrolases; C487496:PncA protein, Mycobacterium tuberculosis