title: Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed.
abstract: Septins comprise a conserved family of GTPase proteins. Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia. In a previous issue of Breast Cancer Research, Connolly and colleagues present compelling data further supporting a role for SEPT9 isoforms in early breast cancer development as well as evidence suggesting that cellular localization patterns of SEPT9 isoforms may contribute to oncogenesis.
authors.forename: Laura
authors.initials: L
authors.lastname: Stanbery
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Petty
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D058112:Septins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D058112:Septins