title: A feedback control model for cortisol secretion.
abstract: Existing mathematical models for cortisol secretion do not describe the entire cortisol secretion process, from the neural firing of corticotropin releasing hormone (CRH) in the hypothalamus to cortisol concentration in the plasma. In this paper, we lay the groundwork to construct a more comprehensive model, relating CRH, Adrenocorticotropic hormone (ACTH), and cortisol. We start with an existing mathematical model for cortisol secretion, and combine it with a simplified neural firing model that describes CRH and ACTH release. This simplified neural firing model is obtained using the extended FitzHugh-Nagumo (FHN) model, which includes a time-varying spiking threshold [3]. A key feature of our model is the presence of a feedback loop from cortisol secretion to ACTH secretion.
authors.affiliation: Laboratory for Information and Decision Systems, Massachusetts Institute of Technology. frfaghih@mit.edu
authors.forename: Rose T
authors.initials: RT
authors.lastname: Faghih
authors.forename: Ketan
authors.initials: K
authors.lastname: Savla
authors.forename: Munther A
authors.initials: MA
authors.lastname: Dahleh
authors.forename: Emery N
authors.initials: EN
authors.lastname: Brown
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003198:Computer Simulation; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone