title: Moderate endurance exercise is not a risk for rhabdomyolysis or renal failure in sickle cell trait carriers.
abstract: This study tested the hypothesis that trained sickle cell trait (SCT) carriers are not subjected to greater risk of rhabdomyolysis or renal failure in response to moderate submaximal exercise than subjects with normal hemoglobin (CONT). Blood markers in 11 trained SCT carriers and 12 control counterparts were measured before and after 40 min of exercise at 55% of peak power output (Ppeak) conducted in thermoneutral environment. Body weights decreased with exercise in the same proportion in the two groups (from 65.1 ± 7.0 kg to 64.1 ± 7.0 kg and from 70.2 ± 6.6 to 68.6 ± 6.6 kg at the end of exercise in SCT and CONT, respectively). Heart rate and rectal temperature increased in the two groups in response to exercise, but the groups remained closely matched. Serum urea, CRP, CK and LDH were similar in the two groups and remained unchanged in response to exercise. Creatinine, Na(+), K(+), Cl(-) and myoglobin concentrations increased above baseline in response to exercise, with changes of the same magnitude in the two groups. In summary, the results of the present study suggest that moderate submaximal exercise is not unsafe from a biochemical point of view for sportsmen carrying SCT.
authors.affiliation: Laboratory of Exercise Physiology, University of Savoie, Chambery, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Messonnier
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Samb
authors.forename: Julien
authors.initials: J
authors.lastname: Tripette
authors.forename: Bertin Doubi
authors.initials: BD
authors.lastname: Gogh
authors.forename: Gylna
authors.initials: G
authors.lastname: Loko
authors.forename: Niama Diop
authors.initials: ND
authors.lastname: Sall
authors.forename: Léonard
authors.initials: L
authors.lastname: Féasson
authors.forename: Olivier
authors.initials: O
authors.lastname: Hue
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lamothe
authors.forename: Pascal
authors.initials: P
authors.lastname: Bogui
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D000328:Adult; D015444:Exercise; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D051437:Renal Insufficiency / Q000209:etiology*; D012206:Rhabdomyolysis / Q000209:etiology*; D012307:Risk Factors; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications*; D055815:Young Adult