title: [Genetic polymorphism of apolipoprotein E in a Peruvian population].
abstract: OBJECTIVE
  To determine the allelic and genotypic frequencies of the APOE gene in a sample of a population group in Peru.
  
  
  METHODS
  Cross-sectional analytic study in 189 apparently healthy volunteers, workers of the Instituto Nacional de Ciencias Neurológicas in Lima, Perú, divided into 5 groups by birth department and two generations ancestry. Genomic DNA was amplified using PCR-RFLP. The resulting fragments were detected by 12 % polyacrylamide gel electrophoresis.
  
  
  RESULTS
  The ε3 allele is the most frequent in all the groups (93.9 %), with low ε4 (5 %) and ε2 (1.1 %) allele frequencies. The analysis of heterozygosity (H) for each group displays intermediate diversity between 10 and 20%. Population genetic diversity (Ht) and diversity within populations (Hs) are 14.43 % and 14.31% respectively, suggesting genetic proximity between the studied groups for the ApoE polymorphism.
  
  
  CONCLUSIONS
  Allele frequencies of the ApoE gene found show that allele ε3 has one of the highest frequencies and ε4 allele one of the lowest compared to other population groups in the world, with possible implications in the risk of neurological, cardiovascular and other diseases in our country.
authors.affiliation: Servicio de Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. peru.neurogenetica@gmail.com
authors.forename: Victoria
authors.initials: V
authors.lastname: Marca
authors.forename: Oscar
authors.initials: O
authors.lastname: Acosta
authors.forename: Mario
authors.initials: M
authors.lastname: Cornejo-Olivas
authors.forename: Olimpio
authors.initials: O
authors.lastname: Ortega
authors.forename: Doris
authors.initials: D
authors.lastname: Huerta
authors.forename: Pilar
authors.initials: P
authors.lastname: Mazzetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E