title: pJIE137 carrying blaCTX-M-62 is closely related to p271A carrying blaNDM-1.
abstract: Complete sequencing of pJIE137 revealed a backbone closely related to p271A, encoding a novel RepA protein but with a similar organization and up to ∼70% nucleotide identity to IncN plasmids. A region in pJIE137 resembling the IncN CUP regulon is mostly missing from p271A, presumably due to recombination. The class 1 In/Tn and ISEcp1-bla(CTX-M-62) transposition unit in pJIE137 and a putative transposon carrying bla(NDM-1) in p271A are inserted in different locations in the plasmid backbone.
authors.affiliation: Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia. sally.partridge@swahs.health.nsw.gov.au
authors.forename: Sally R
authors.initials: SR
authors.lastname: Partridge
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Iredell
mesh_terms: D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology* / Q000235:genetics*; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D010957:Plasmids / Q000235:genetics; D011995:Recombination, Genetic; D018085:Regulon / Q000235:genetics; D009626:Terminology as Topic; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004269:DNA, Bacterial; C573057:beta lactamase CTX-M-62, Klebsiella pneumoniae; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1