title: Endothelial cells and magnesium: implications in atherosclerosis.
abstract: There is no doubt that the functional and structural integrity of the endothelium is critical in maintaining vascular homoeostasis and in preventing atherosclerosis. In the light of epidemiological and experimental studies, magnesium deficiency is emerging as an inducer of endothelial dysfunction. In particular, data on the effects of low extracellular magnesium on cultured endothelial cells reinforce the idea that correcting magnesium homoeostasis might be a helpful and inexpensive intervention to prevent and treat endothelial dysfunction and, consequently, atherosclerosis.
authors.affiliation: Dipartimento di Scienze Cliniche L. Sacco, Università di Milano, Via G.B. Grassi 74, Milano, Italy. jeanette.maier@unimi.it
authors.forename: Jeanette A M
authors.initials: JA
authors.lastname: Maier
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D002199:Capillary Permeability; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D053582:Interleukin-1alpha / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology / Q000502:physiology*; D008275:Magnesium Deficiency / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008955:Models, Cardiovascular; D016328:NF-kappa B / Q000502:physiology; D018384:Oxidative Stress; D010447:Peptide Hydrolases / Q000096:biosynthesis; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology
chemical_list: D053582:Interleukin-1alpha; D016328:NF-kappa B; D010447:Peptide Hydrolases; D008274:Magnesium