title: An efficient synthesis of aripiprazole, buspirone and NAN-190 by the reductive alkylation of amines procedure.
abstract: The reductive alkylation of amines procedure was applied for the synthesis of aripiprazole 1a, buspirone 1b, and NAN-190 1c.
authors.affiliation: Cracow University of Technology, Institute of Organic Chemistry and Technology, Cracow, Poland. kowapi@pk.edu.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Kowalski
authors.forename: Jolanta
authors.initials: J
authors.lastname: Jaśkowska
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D000068180:Aripiprazole; D002065:Buspirone / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006868:Hydrolysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
chemical_list: D000588:Amines; D010879:Piperazines; D015363:Quinolones; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D000068180:Aripiprazole; D002065:Buspirone