title: P-bodies and their functions during mRNA cell cycle: mini-review.
abstract: P-bodies (processing bodies) are observed in different organisms such as yeast, Caenorhabditis elegans and mammals. A typical eukaryotic cell contains several types of spatially formed granules, such as P-bodies, stress granules and a variety of ribonucleoprotein bodies. These microdomains play important role in mRNA processing, including RNA interference, repression of translation and mRNA decay. The P-bodies components as well as stress granules may play an important role in host defense against viral infection. The complete set of P-bodies protein elements is still poor known. They contain conserved protein core limited to different organisms or to stress status of the cell. P-bodies are related also to some neuronal mRNA granules as well as to maternal RNA granules or male germ cell granules. In this mini-review, we focus on the structure of P-bodies and their function in the mRNA utilization and processing because of the high mRNA's dynamics between different cellular compartments and its key role in modulation of gene expression.
authors.affiliation: Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Olszewska
authors.forename: Józef J
authors.initials: JJ
authors.lastname: Bujarski
authors.forename: Maciej
authors.initials: M
authors.lastname: Kurpisz
mesh_terms: D000818:Animals; D002453:Cell Cycle; D003594:Cytoplasmic Granules / Q000235:genetics / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger