title: Direct O-glycosidation of resin bound thioglycosides.
abstract: The application of the safety-catch linker concept to solid-phase glycoconjugate synthesis is described. The process allows for direct conjugation of resin bound glycans to complex aglycones during cleavage. Large excesses of either coupling partner are not required, and even very hindered alcohols serve as acceptors in the reaction.
authors.affiliation: Department of Chemistry, Tufts University, Medford, MA 02155, USA.
authors.forename: Son Hong
authors.initials: SH
authors.lastname: Nguyen
authors.forename: Adam H
authors.initials: AH
authors.lastname: Trotta
authors.forename: John
authors.initials: J
authors.lastname: Cao
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Straub
authors.forename: Clay S
authors.initials: CS
authors.lastname: Bennett
mesh_terms: D000438:Alcohols / Q000737:chemistry; D004187:Disaccharides / Q000737:chemistry; D006031:Glycosylation; D015394:Molecular Structure; D013865:Thioglycosides / Q000737:chemistry*
chemical_list: D000438:Alcohols; D004187:Disaccharides; D013865:Thioglycosides