title: Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells.
abstract: Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
authors.affiliation: Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, National Cancer Institute, 211 Building 567, 1050 Boyles Street, NCI-Frederick, Frederick, MD, 21702, USA. hurwitza@mail.nih.gov.
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hurwitz
authors.affiliation: Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, National Cancer Institute, 211 Building 567, 1050 Boyles Street, NCI-Frederick, Frederick, MD, 21702, USA.
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Watkins
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D019139:Tumor Escape; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm