title: Population pharmacokinetics of telavancin in healthy subjects and patients with infections.
abstract: A population pharmacokinetic model of telavancin, a lipoglycopeptide antibiotic, was developed and used to identify sources of interindividual variability. Data were obtained from healthy subjects (seven phase 1 studies), patients with complicated skin and skin structure infections (cSSSI; two phase 2 and two phase 3 studies), and patients with hospital-acquired pneumonia (HAP; two phase 3 studies). A two-compartment open model with zero-order input best fit the telavancin data from healthy individuals and patients with cSSSI or HAP. Telavancin clearance was highly correlated with renal function and, to a lesser extent, with body weight. Other covariates were related to at least one parameter in cSSSI (gender, bacterial eradication, and surgery) or HAP (age of ≥ 75 years) but did not markedly affect exposure. These analyses support current dosing recommendations for telavancin based on patient weight and renal function.
authors.affiliation: PharmaPolaris International, Inc., Danville, California, USA.
authors.forename: Emil
authors.initials: E
authors.lastname: Samara
authors.forename: Jeng-Pyng
authors.initials: JP
authors.lastname: Shaw
authors.forename: Steven L
authors.initials: SL
authors.lastname: Barriere
authors.forename: Shekman L
authors.initials: SL
authors.lastname: Wong
authors.forename: Philip
authors.initials: P
authors.lastname: Worboys
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000617:Aminoglycosides / Q000097:blood / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000378:metabolism*; D001499:Bayes Theorem; D001835:Body Weight / Q000502:physiology; D002138:Calibration; D003428:Cross Infection / Q000378:metabolism; D005260:Female; D006801:Humans; D000077427:Lipoglycopeptides; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011153:Population; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C487637:telavancin