title: [Cell therapy for aseptic necrosis of femoral head].
abstract: As the clinical application of mesenchymal stem cell (MSC), we have engaged in the development of cell transplantation therapy for aseptic necrosis of femoral head. Based on the results obtained by in vitro and in vivo preclinical experiments, we established the protocol for the clinical trial combining MSC with vascularized bone grafts. The protocol was approved by IRB on November 25, 2007, and the first case was operated on February 22, 2008. Since then 10 cases have been successfully treated and were followed at least 24 months with satisfactory results.
authors.affiliation: Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University.
authors.forename: Junya
authors.initials: J
authors.lastname: Toguchida
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aoyama
authors.forename: Koji
authors.initials: K
authors.lastname: Goto
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kakinoki
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Kasai
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods; D005271:Femur Head Necrosis / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*