title: Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature.
abstract: OBJECTIVE
  We present, for the first time, the cytological features of lymphoepithelioma-like carcinoma (LELC) of the breast in preoperative fine-needle aspiration (FNA) and touch imprints from secondary deposits in the sentinel lymph node (SLN).
  
  
  METHODS
  We report a case of a 53-year-old woman who was diagnosed with breast carcinoma on preoperative FNA and was subjected to SLN biopsy, partial mastectomy and axillary lymph node dissection. The final diagnosis was LELC of the breast. Cytological and histological features were analyzed.
  
  
  RESULTS
  The smears from preoperative FNA contained cohesive clusters and isolated tumour cells in a haemorrhagic background with scattered lymphocytes. Some of the clusters were infiltrated by the inflammatory cells. The cells had large, pleomorphic nuclei and scanty, ill-defined cytoplasm. The intraoperative touch imprints from the SLN were highly cellular, comprising abundant scattered lymphoid cells, among which were tight clusters of indistinct cells, about 3 times larger than the lymphocyte population.
  
  
  CONCLUSIONS
  In our case, LELC shares many cytological features with LELC described in other organs. Immunostains with epithelial markers play an important role in establishing the epithelial nature of the neoplastic cells. LELC should be borne in mind in the evaluation of breast lesions with prominent lymphoid cell infiltration. Its cytological features, as presented, could contribute to its preoperative evaluation on cytological grounds.
authors.affiliation: Department of Pathology, 'Metaxas' Anticancer Hospital, Piraeus, Greece. ntrap@tee.gr
authors.forename: H
authors.initials: H
authors.lastname: Trihia
authors.forename: H
authors.initials: H
authors.lastname: Siatra
authors.forename: H
authors.initials: H
authors.lastname: Gklisty
authors.forename: P
authors.initials: P
authors.lastname: Diamantopoulos
authors.forename: P
authors.initials: P
authors.lastname: Arapantoni-Dadiotis
authors.forename: K
authors.initials: K
authors.lastname: Kalogerakos
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D021701:Sentinel Lymph Node Biopsy
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018396:Mucin-1