title: Critique of "Stenting versus aggressive medical therapy for intracranial arterial stenosis" by Chimowitz et al in the new England Journal of Medicine.
abstract: Symptomatic intracranial stenoses are an important cause of stroke and have a high risk of recurrent stroke with medical therapy. The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Arterial Stenosis (SAMMPRIS) trial unexpectedly showed a higher-than-expected rate of complications with intracranial stenting and a lower-than-expected recurrence rate with medical therapy. In this commentary, the authors review possible explanations for these findings and suggest future strategies for study.
authors.affiliation: Department of Neurology, Room 113, University of Louisville, 500 S Preston Street, Louisville, KY 40202, USA. A0abou03@louisville.edu
authors.forename: Alex
authors.initials: A
authors.lastname: Abou-Chebl
authors.forename: Helmuth
authors.initials: H
authors.lastname: Steinmetz
mesh_terms: D002539:Cerebral Arterial Diseases / Q000601:surgery* / Q000628:therapy*; D003251:Constriction, Pathologic; D016894:Endarterectomy, Carotid; D006801:Humans; D012008:Recurrence; D018570:Risk Assessment; D015607:Stents / Q000009:adverse effects; D020521:Stroke / Q000601:surgery* / Q000628:therapy*