title: Post-translational oxidative modification of β2-glycoprotein I and its role in the pathophysiology of the antiphospholipid syndrome.
abstract: Vascular thrombosis and/or recurrent miscarriages are the main characteristics defining Antiphospholipid Syndrome (APS). Currently there is no well-defined clinical features and/or laboratory tests that predicts the risk of adverse prognostic outcomes in APS. In this short review, we report the importance of posttranslational modification of beta2 glycoprotein I, the major autoantigen in the APS beta2 glycoprotein I that may, in part, explain possible mechanisms for the generation of auto antibodies to beta2 glycoprotein I. A specific ELISA measuring the level of oxidised beta2 glycoprotein I could be used as a potential new laboratory test - along with other laboratory tests - to more accurately predict the risk of having a clinical event in patients with APS.
authors.affiliation: Department of Immunology, Allergy and Infectious Diseases, St. George Hospital, University of New South Wales, Sydney, Australia.
authors.forename: Peyman
authors.initials: P
authors.lastname: Mirarabshahi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abdelatti
authors.forename: Steven
authors.initials: S
authors.lastname: Krilis
mesh_terms: D000818:Animals; D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000378:metabolism*; D001323:Autoantibodies / Q000276:immunology; D006801:Humans; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D053482:beta 2-Glycoprotein I / Q000276:immunology* / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D053482:beta 2-Glycoprotein I