title: Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea.
abstract: We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.
authors.affiliation: Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Sackler Faulty of Medicine, Tel Aviv University, Tel Aviv, Israel. vaisman@tasmc.health.gov.il
authors.forename: Nachum
authors.initials: N
authors.lastname: Vaisman
authors.forename: Josef
authors.initials: J
authors.lastname: Press
authors.forename: Eugene
authors.initials: E
authors.lastname: Leibovitz
authors.forename: Güenther
authors.initials: G
authors.lastname: Boehm
authors.forename: Vivian
authors.initials: V
authors.lastname: Barak
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005243:Feces / Q000382:microbiology; D005690:Galactose / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007378:Interleukins / Q000097:blood; D009844:Oligosaccharides / Q000008:administration & dosage*; D010919:Placebos; D056692:Prebiotics; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D007378:Interleukins; D009844:Oligosaccharides; D010919:Placebos; D056692:Prebiotics; D014409:Tumor Necrosis Factor-alpha; C116580:fructooligosaccharide; D005690:Galactose