title: Candida spp. with acquired echinocandin resistance, France, 2004-2010.
abstract: We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.
authors.affiliation: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, 25, Rue du Dr. Roux, 75724 Paris Cedex 15, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Dannaoui
authors.forename: Marie
authors.initials: M
authors.lastname: Desnos-Ollivier
authors.forename: Dea
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: Fredéric
authors.initials: F
authors.lastname: Grenouillet
authors.forename: Sophie
authors.initials: S
authors.lastname: Cassaing
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Baixench
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bretagne
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects*; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins