title: Diagnostic significance of hepatitis B viral antigens in patients with glomerulonephritis-associated hepatitis B virus infection.
abstract: Hepatitis B viral infection can lead to hepatitis B virus-associated glomerulonephritis, a clinically significant subtype of secondary nephritis. In the present study, we examined the presence of PreS1/S2 antigen in renal tissues by use of immunohistochemistry and investigated the use of PreS1/S2 and 2 HBV serum antigens, HBe-Ag and HBs-Ag, in the diagnosis. We assessed the presence of these 3 antigens in patients with confirmed hepatitis B virus-associated glomerulonephritis (n = 22) and patients without this disease (n = 19). Our results indicate that the combined use of PreS1/S2-Ag and serum HBe-Ag in the diagnosis of hepatitis B virus-associated glomerulonephritis had good positive predictive value (0.89), modest negative predictive value (0.77), and substantial agreement based on Cohen's kappa coefficient (κ = 0.660, P < 0.001). We suggest that our results be considered in the development of more definitive diagnostic criteria for hepatitis B virus-associated glomerulonephritis.
authors.affiliation: Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. ericshi412@sina.com
authors.forename: Chenggang
authors.initials: C
authors.lastname: Shi
authors.forename: Jiyi
authors.initials: J
authors.lastname: Huang
authors.forename: Xun
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zeng
authors.forename: Cailian
authors.initials: C
authors.lastname: Cheng
authors.forename: Qiongli
authors.initials: Q
authors.lastname: Yin
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Guifeng
authors.initials: G
authors.lastname: Cheng
mesh_terms: D000328:Adult; D005260:Female; D015967:Gene Expression Regulation, Viral; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis*; D006511:Hepatitis B Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006511:Hepatitis B Antigens