title: Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma.
abstract: BACKGROUND
  Omalizumab may inhibit allergic inflammation and could contribute to decreasing airway remodeling in patients with asthma.
  
  
  OBJECTIVE
  The aim of this study was to assess the effects of omalizumab on airway wall thickness using computed tomography (CT).
  
  
  METHODS
  Thirty patients with severe persistent asthma were randomized to conventional therapy with (n = 14) or without omalizumab (n = 16) for 16 weeks. The following airway dimensions were assessed by a validated CT technique: airway wall area corrected for body surface area (WA/BSA), percentage wall area (WA%), wall thickness (T)/√BSA, and luminal area (Ai)/BSA at the right apical segmental bronchus. The percentage of eosinophils in induced sputum, pulmonary function and the Asthma Quality of Life Questionnaire (AQLQ) were assessed as well.
  
  
  RESULTS
  Treatment with omalizumab significantly decreased WA/BSA (p < 0.01), WA% (p < 0.01), and T/√BSA (p < 0.01), and increased Ai/BSA (p < 0.05), whereas conventional therapy resulted in no change. In the omalizumab group (n = 14), a significant decrease in the percentage of sputum eosinophils (p < 0.01), improved forced expiratory volume in 1 s (FEV(1)), and an improved AQLQ score were recorded. The changes in FEV(1)% predicted and sputum eosinophils were significantly correlated with changes in WA% (r = 0.88, p < 0.001, and r = 072, p < 0.01, respectively).
  
  
  CONCLUSIONS
  These findings suggest that omalizumab reduced airway wall thickness and airway inflammation. Larger patient studies with longer-term follow-up are needed to show whether omalizumab can truly maintain improved airway wall dimensions.
authors.affiliation: Department of Respiratory Medicine, Atami Hospital, International University of Health and Welfare, Atami, Japan. hoshino@iuhw.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Hoshino
authors.forename: Junichi
authors.initials: J
authors.lastname: Ohtawa
mesh_terms: D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D000069444:Omalizumab; D011788:Quality of Life; D012129:Respiratory Function Tests; D013183:Sputum / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D018927:Anti-Asthmatic Agents; D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; D000069444:Omalizumab