title: A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics.
abstract: Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched.
authors.affiliation: School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia. kelly.murphy@qut.edu.au
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Murphy
authors.forename: Cameron L
authors.initials: CL
authors.lastname: Hall
authors.forename: Philip K
authors.initials: PK
authors.lastname: Maini
authors.forename: Scott W
authors.initials: SW
authors.lastname: McCue
authors.forename: D L Sean
authors.initials: DL
authors.lastname: McElwain
mesh_terms: D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007700:Kinetics; D055595:Mechanical Phenomena; D008954:Models, Biological; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D003094:Collagen; D017364:Collagenases