title: Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
abstract: OBJECTIVE
  To assess the relationship between interleukin (IL)-1-related molecules, infarct size and left ventricular (LV) remodelling following acute myocardial infarction (MI).
  
  
  METHODS
  Forty-two patients with first-time diagnosis of ST segment elevation MI (STEMI), with a single occluded vessel successfully revascularized by primary percutaneous coronary intervention (PCI), were recruited to this observational study conducted at a university teaching hospital and followed for 1 year.
  
  
  METHODS
  Plasma levels of IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18 and caspase-1 were analysed before and 2 days, 1 week and 2 months after PCI. Serial cardiac magnetic resonance imaging (CMR) was used for the assessment of infarct size and LV remodelling. CMR findings at 1 year was the primary outcome variable.
  
  
  RESULTS
  Univariate analysis showed that IL-1-related mediators were strongly (IL-1 β), moderately (caspase-1) and weakly (IL-1Ra) associated with impaired myocardial function and noninfarct mass, but not infarct size, 1 year after reperfused STEMI. In multivariate analyses, troponin T predicted LV ejection fraction (LVEF), infarct size and LV end-diastolic (LVEDVi) and end-systolic volume index (LVESVi). However, significant additional variance was explained by IL-1β, IL-18 and caspase-1. IL-1β levels at 2 months, IL-18 at 2 days and pre-PCI caspase-1 were predictors of LVEF. Caspase-1 and in particular IL-1β at 2 days were the only predictors of noninfarct mass. IL-1β and IL-18 at 2 days were predictors of LVEDVi, whilst pre-PCI levels of IL-1β contributed to prediction of LVESVi. By contrast, pro-B-type natriuretic peptide, C-reactive protein, IL-6 and transforming growth factor-β1 (TGF-β1) had no or only a weak (TGF-β1) association with these CMR parameters in multivariate analyses.
  
  
  CONCLUSIONS
  IL-1β levels after STEMI were strongly associated with impaired myocardial function and noninfarct LV mass after 1 year, suggesting a potential role for IL-1β as a predictor of maladaptive myocardial remodelling following reperfused MI.
authors.affiliation: Division of Cardiology, Stavanger University Hospital, Stavanger Research Institute of Internal Medicine, Oslo, Norway. drsteinorn@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Ørn
authors.forename: T
authors.initials: T
authors.lastname: Ueland
authors.forename: C
authors.initials: C
authors.lastname: Manhenke
authors.forename: Ø
authors.initials: Ø
authors.lastname: Sandanger
authors.forename: K
authors.initials: K
authors.lastname: Godang
authors.forename: A
authors.initials: A
authors.lastname: Yndestad
authors.forename: T E
authors.initials: TE
authors.lastname: Mollnes
authors.forename: K
authors.initials: K
authors.lastname: Dickstein
authors.forename: P
authors.initials: P
authors.lastname: Aukrust
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000032:analysis; D020170:Caspase 1 / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000473:pathology; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood*; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology / Q000628:therapy*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D013318:Stroke Volume; D053773:Transforming Growth Factor beta1 / Q000097:blood; D020107:Troponin T / Q000097:blood; D020257:Ventricular Remodeling
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D020382:Interleukin-18; D053583:Interleukin-1beta; D010446:Peptide Fragments; D053773:Transforming Growth Factor beta1; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein; D020170:Caspase 1