title: Praziquantel derivatives exhibit activity against both juvenile and adult Schistosoma japonicum.
abstract: A praziquantel analog 10-hydroxy praziquantel and eight praziquantel/peroxide conjugates were synthesized. The biological activity of these compounds was evaluated against juvenile and adult stages of Schistosoma japonicum. Unlike praziquantel, 10-hydroxy praziquantel exhibits activity against both juvenile and adult Schistosoma japonicumin. All hybrid compounds displayed modest to significant worm killing activity. The present study has important significance for the development of hybrid antischistosomal drugs.
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou, China.
authors.forename: Wen-wen
authors.initials: WW
authors.lastname: Duan
authors.forename: Si-jie
authors.initials: SJ
authors.lastname: Qiu
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.forename: Chunhua
authors.initials: C
authors.lastname: Qiao
authors.forename: Chao-ming
authors.initials: CM
authors.lastname: Xia
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D011223:Praziquantel / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012549:Schistosoma japonicum / Q000187:drug effects*; D012554:Schistosomiasis japonica / Q000188:drug therapy*; D012556:Schistosomicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D012556:Schistosomicides; D011223:Praziquantel