title: Stability of MEG for real-time neurofeedback.
abstract: Movement-related field potentials can be extracted and processed in real-time with magnetoencephalography (MEG) and used for brain machine interfacing (BMI). However, due to its immense sensitivity to magnetic fields, MEG is prone to a low signal to noise ratio. It is therefore important to collect enough initial data to appropriately characterize motor-related activity and to ensure that decoders can be built to adequately translate brain activity into BMI-device commands. This is of particular importance for therapeutic BMI applications where less time spent collecting initial open-loop data means more time for performing neurofeedback training which could potentially promote cortical plasticity and rehabilitation. This study evaluated the amount of hand-grasp movement and rest data needed to characterize sensorimotor modulation depth and build classifier functions to decode brain states in real-time. It was determined that with only five minutes of initial open-loop MEG data, decoders can be built to classify brain activity as grasp or rest in real-time with an accuracy of 84 ± 6%.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA. stephen.foldes@gmail.com
authors.forename: S T
authors.initials: ST
authors.lastname: Foldes
authors.forename: R K
authors.initials: RK
authors.lastname: Vinjamuri
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: D J
authors.initials: DJ
authors.lastname: Weber
authors.forename: J L
authors.initials: JL
authors.lastname: Collinger
mesh_terms: D000465:Algorithms; D001676:Biofeedback, Psychology / Q000379:methods* / Q000502:physiology*; D003199:Computer Systems; D004569:Electroencephalography / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity