title: Agonist trigger: what is the best approach? Agonist trigger with aggressive luteal support.
abstract: Although gonadotropin-releasing hormone agonist (GnRHa) trigger is effective in the prevention of ovarian hyperstimulation syndrome, lower conception rates have been reported. Intensive luteal phase support is an effective approach to improve implantation rates in women with peak E(2) levels ≥ 4,000 pg/mL. However, patients with peak E(2) levels <4,000 pg/mL may require a dual trigger with GnRHa and 1,000 IU hCG and intensive luteal phase support to improve implantation rates.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut 06030-6224, USA. lengmann@uchc.edu
authors.forename: Lawrence
authors.initials: L
authors.lastname: Engmann
authors.forename: Claudio
authors.initials: C
authors.lastname: Benadiva
mesh_terms: D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D010064:Embryo Implantation; D004958:Estradiol / Q000097:blood; D019317:Evidence-Based Medicine; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D010060:Ovulation / Q000187:drug effects* / Q000378:metabolism; D010062:Ovulation Induction / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol