title: Adolescent female with withdrawal psychosis following abrupt termination of ziprasidone.
abstract: It is widely known that discontinuation reactions can occur after neuroleptics are stopped resulting in dyskinesia through its effect on the nigrostriatal pathway. Less discussed is the concept of "supersensitivity psychosis" which has been described as a rapid onset of psychosis after a neuroleptic medication has been withdrawn. Although the concept of supersensitivity psychosis has been described with the discontinuation of some neuroleptics, it has not been described with ziprasidone. Furthermore, the following case report is the first time that this phenomenon has been described in an adolescent patient who has discontinued ziprasidone. Reasons for supersensitivity psychosis are explored in addition to suggestions about precautions about prescribing neuroleptics in young people.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Child and Adolescent Division, Emory University Hospital, 1256 Briarcliff Road Suite 309 East, Atlanta, GA, 30306, USA. mkjacob@emory.edu
authors.forename: Maryann K
authors.initials: MK
authors.lastname: Jacob
authors.forename: Peter
authors.initials: P
authors.lastname: Ash
authors.forename: W Edward
authors.initials: WE
authors.lastname: Craighead
mesh_terms: D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006212:Hallucinations / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D010879:Piperazines / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000188:drug therapy; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone