title: Expression of circadian Per1 and Per2 genes in the liver and breast tumor tissues of HER2/neu transgenic mice of different age.
abstract: The expression of Per1, Per2, and Cry1 circadian genes in the liver and breast tumors were studied by real-time PCR in FVB/N mice of different age transfected with HER-2/neu gene. The expression of Per1 and Per2 genes in breast tumor tissue decreased in comparison with their expression in the lever. The expression of these genes decreased with age in both the liver and tumor tissue.
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Kolomeichuk
authors.forename: E V
authors.initials: EV
authors.lastname: Gurov
authors.forename: T S
authors.initials: TS
authors.lastname: Piskunova
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D005260:Female; D015870:Gene Expression; D008099:Liver / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D056950:Period Circadian Proteins / Q000235:genetics* / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases
chemical_list: D056950:Period Circadian Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; C524056:Erbb2 protein, mouse