title: Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice.
abstract: Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.
authors.affiliation: Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA.
authors.forename: Antje
authors.initials: A
authors.lastname: Bruckbauer
authors.affiliation: Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Zemel
mesh_terms: D050154:Adiposity / Q000187:drug effects; D054366:Agouti Signaling Protein / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002136:Calcium, Dietary / Q000494:pharmacology*; D016022:Case-Control Studies; D003611:Dairy Products; D004032:Diet; D004195:Disease Models, Animal; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008017:Life Expectancy; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D054366:Agouti Signaling Protein; D015415:Biomarkers; D002136:Calcium, Dietary; C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; C515183:a protein, mouse