title: Verbal fluency in patients receiving bilateral versus left-sided deep brain stimulation of the subthalamic nucleus for Parkinson's disease.
abstract: The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation.
authors.affiliation: Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden. rickard.l.sjoberg@gmail.com
authors.forename: Rickard L
authors.initials: RL
authors.lastname: Sjöberg
authors.forename: Elin
authors.initials: E
authors.lastname: Lidman
authors.forename: Björn
authors.initials: B
authors.lastname: Häggström
authors.forename: Marwan I
authors.initials: MI
authors.lastname: Hariz
authors.forename: Jan
authors.initials: J
authors.lastname: Linder
authors.forename: Anna
authors.initials: A
authors.lastname: Fredricks
authors.forename: Patric
authors.initials: P
authors.lastname: Blomstedt
mesh_terms: D000368:Aged; D001288:Attention / Q000502:physiology; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000628:therapy; D011569:Psychiatric Status Rating Scales; D013064:Speech Disorders / Q000209:etiology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*