title: β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus.
abstract: OBJECTIVE
  To compare β-cell function in adolescents and adults with newly diagnosed type 2 diabetes (T2DM).
  
  
  METHODS
  Thirty-nine adolescents with T2DM, 38 age- and weight-matched control subjects, and 19 adults with T2DM were studied. The adolescent subjects with diabetes were divided on the basis of whether they needed insulin to control their initial hyperglycemia. The primary outcome variable was the disposition index, computed from the acute insulin response to glucose corrected for insulin sensitivity (1/Homeostatic model assessment of insulin resistance).
  
  
  RESULTS
  The disposition index was significantly reduced in all 3 diabetic groups (control n=3360, adolescents with T2DM without insulin n=630, adolescents with T2DM with insulin n=120, adults with T2DM n=200; P<.001), and the adolescents with more severe hyperglycemia at diagnosis had lower disposition index than those with a more modest presentation (P<.05).
  
  
  CONCLUSIONS
  At the time of diagnosis, adolescents with T2DM have significant β-cell dysfunction, comparable with adults newly diagnosed with T2DM. Thus, severe β-cell impairment can develop within the first two decades of life and is likely to play a central role in the pathogenesis of T2DM in adolescents.
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. deborah.elder@cchmc.org
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Elder
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Herbers
authors.forename: Tammy
authors.initials: T
authors.lastname: Weis
authors.forename: Debra
authors.initials: D
authors.lastname: Standiford
authors.forename: Jessica G
authors.initials: JG
authors.lastname: Woo
authors.forename: David A
authors.initials: DA
authors.lastname: D'Alessio
mesh_terms: D000293:Adolescent; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007328:Insulin