title: Pathogenetic role of Yersinia pseudotuberculosis endotoxin in hemostasis and microcirculation disturbances.
abstract: We studied the role of Y. pseudotuberculosis endotoxin (LPS) in the pathogenesis of hemostasis and microcirculation disorders. It was found that changes in the hemostasis system after injection of LPS had biphasic character corresponding to the stages of DIC syndrome development. Pathomorphological findings in animals with endotoxemia induced by Y. pseudotuberculosis LPS attested to increased permeability and destruction of the vascular endothelium in the microcirculatory bed and focal degenerative and necrotic changes in cells of the target organs (kidney, liver, and lungs) progressing with increasing the duration of the pathological process, which was determined by microcirculation disturbances and development of multiple organ failure.
authors.affiliation: Laboratory of Immunology, Siberian Branch of Russian Academy of Medical Science, Vladivostok, Russia. takuznets@mail.ru
authors.forename: T A
authors.initials: TA
authors.lastname: Kuznetsova
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.forename: E I
authors.initials: EI
authors.lastname: Drobot
mesh_terms: D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology*; D019446:Endotoxemia / Q000382:microbiology; D007668:Kidney / Q000473:pathology; D008070:Lipopolysaccharides / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008833:Microcirculation; D009102:Multiple Organ Failure / Q000473:pathology*; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides