title: The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules.
abstract: The pertussis epidemic experienced in NSW in 2008-2009 was likely to be in part due to changes in diagnostic practice since 2007, which amplified disease notifications. We used population-based seroepidemiology as a less biased means of interpreting age-specific pertussis infection patterns in NSW from three serosurveys undertaken in 1997-98 (during an epidemic), 2002 (post-epidemic) and 2007 (inter-epidemic), using a standardised pertussis toxin IgG enzyme-linked immunosorbent assay (ELISA). There was a decrease in the proportion of high anti-pertussis toxin IgG titres (>62.5ELISAUnits/mL) across all age groups in the 2007 serosurvey compared to the previous two serosurveys. In the 2007 serosurvey, the proportion of undetectable (<5ELISAUnits/mL) anti-pertussis toxin IgG titres increased in many age groups. The seroepidemiological profiles of the three serosurveys demonstrate fluctuating immunity profiles related to changes in vaccination schedules.
authors.affiliation: National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead. HelenQ@chw.edu.au
authors.forename: Helen E
authors.initials: HE
authors.lastname: Quinn
authors.forename: Deepika
authors.initials: D
authors.lastname: Mahajan
authors.forename: Linda
authors.initials: L
authors.lastname: Hueston
authors.forename: Patricia
authors.initials: P
authors.lastname: Campbell
authors.forename: Robert I
authors.initials: RI
authors.lastname: Menzies
authors.forename: Gwendolyn L
authors.initials: GL
authors.lastname: Gilbert
authors.forename: Peter B
authors.initials: PB
authors.lastname: McIntyre
mesh_terms: D000293:Adolescent; D000328:Adult; D001886:Bordetella pertussis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D018563:Disease Notification; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007109:Immunity / Q000276:immunology; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D014917:Whooping Cough / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G