title: Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.
abstract: Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported. Alternative treatment containing vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.
authors.affiliation: Department of Pediatrics, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. mizuho@med.hokudai.ac.jp
authors.forename: Mizuho
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Inamoto
authors.forename: Junjiro
authors.initials: J
authors.lastname: Ohshima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Cho
authors.forename: Shinji
authors.initials: S
authors.lastname: Saitoh
authors.forename: Makoto
authors.initials: M
authors.lastname: Kaneda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Iguchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D014750:Vincristine / Q000009:adverse effects*; D014751:Vindesine / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D014751:Vindesine