title: Isolated Histoplasma capsulatum meningoencephalitis in an immunocompetent child.
abstract: Histoplasmosis with central nervous system involvement typically arises in the immunocompromised patient with disseminated fungal disease. Rarely, neurologic histoplasmosis may arise as an isolated syndrome in immunocompetent individuals without evidence of general dissemination. The disease often is diagnostically challenging, and a high index of suspicion is required for diagnosis. We describe an immunocompetent 13-year-old girl with atypical symptoms and unusual radiologic findings due to laboratory-confirmed histoplasma meningoencephalitis. She responded well to antifungal therapy.
authors.affiliation: Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536-0281, USA.
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Threlkeld
authors.forename: Robert
authors.initials: R
authors.lastname: Broughton
authors.forename: Gulam Q
authors.initials: GQ
authors.lastname: Khan
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Berger
mesh_terms: D000293:Adolescent; D005260:Female; D006658:Histoplasma / Q000472:pathogenicity*; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000175:diagnosis / Q000209:etiology*