title: Lung function before and after pediatric allogeneic hematopoietic stem cell transplantation: a predictive role for DLCOa/VA.
abstract: BACKGROUND
  Pre-allogeneic hematopoietic stem cell transplantation (aHSCT) and post-aHSCT lung function of 41 eligible patients at Riley Hospital for Children were assessed to identify risk factors for post-aHSCT morbidity and mortality.
  
  
  METHODS
  One year post-aHSCT pulmonary function tests were significantly lower compared with baseline. These findings recovered at 2 years post-aHSCT. Refractory disease before aHSCT correlated with lower pulmonary function tests after aHSCT. Graft-versus-host disease was significantly associated with higher post-aHSCT residual volume. Importantly, low pre-aHSCT carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume was predictive of death.
  
  
  CONCLUSIONS
  Among survivors, lung function improves over time after pediatric aHSCT. Measurement of carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume before pediatric aHSCT should be further investigated as a predictor of pulmonary dysfunction and mortality.
authors.affiliation: Sections of Pediatric Hematology/Oncology/Hematopoietic Stem Cell Transplantation, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Troy C
authors.initials: TC
authors.lastname: Quigg
authors.forename: Young-Jee
authors.initials: YJ
authors.lastname: Kim
authors.forename: W Scott
authors.initials: WS
authors.lastname: Goebel
authors.forename: Paul R
authors.initials: PR
authors.lastname: Haut
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000401:mortality / Q000503:physiopathology*; D019337:Hematologic Neoplasms / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011237:Predictive Value of Tests; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014184:Transplantation, Homologous