title: Alzheimer's disease risk factor complement receptor 1 is associated with depression.
abstract: Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
authors.affiliation: Medical Genetics, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK. g.hamilton@ed.ac.uk
authors.forename: Gillian
authors.initials: G
authors.lastname: Hamilton
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Evans
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Macintyre
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Deary
authors.forename: Anna
authors.initials: A
authors.lastname: Dominiczak
authors.forename: Blair H
authors.initials: BH
authors.lastname: Smith
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morris
authors.forename: David J
authors.initials: DJ
authors.lastname: Porteous
authors.forename: Pippa A
authors.initials: PA
authors.lastname: Thomson
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics*; D003863:Depression / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011951:Receptors, Complement / Q000235:genetics*; D012606:Scotland
chemical_list: D011951:Receptors, Complement