title: Access to pyrrolo-pyridines by gold-catalyzed hydroarylation of pyrroles tethered to terminal alkynes.
abstract: In a simple procedure, the intramolecular hydroarylation of N-propargyl-pyrrole-2-carboxamides was accomplished with the aid of gold(III) catalysis. The reaction led to differently substituted pyrrolo[2,3-c]pyridine and pyrrolo[3,2-c]pyridine derivatives arising either from direct cyclization or from a formal rearrangement of the carboxamide group. Terminal alkynes are essential to achieve bicyclic pyrrolo-fused pyridinones by a 6-exo-dig process, while the presence of a phenyl group at the C-C triple bond promotes the 7-endo-dig cyclization giving pyrrolo-azepines.
authors.affiliation: Dipartimento di Scienze Chimiche e Ambientali Università dell'Insubria, Via Valleggio 11, 22100 Como, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Borsini
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Broggini
authors.forename: Andrea
authors.initials: A
authors.lastname: Fasana
authors.forename: Chiara
authors.initials: C
authors.lastname: Baldassarri
authors.forename: Angelo M
authors.initials: AM
authors.lastname: Manzo
authors.forename: Alcide D
authors.initials: AD
authors.lastname: Perboni