title: Nail discoloration due to tinzaparin sodium.
abstract: Tinzaparin sodium is a low molecular weight heparin formed by the enzymatic degradation of porcine unfractionated heparin, and is effective in the prevention and treatment of thromboembolic disease. We report a 31-year-old female patient with a history of recurrent pregnancy loss due to thrombophilia, who developed nail discoloration after 8 weeks of tinzaparin sodium therapy. No other pigmentation was found elsewhere on the skin, mucous membranes, teeth, or sclerae. To our knowledge, nail pigmentation following tinzaparin sodium therapy is an unknown side effect and has not been reported previously in the English literature.
authors.affiliation: Department of Dermatology, Ankara Kecioren Research and Training Hospital, Ankara, Turkey. drzennure80@yahoo.com
authors.forename: Zennure
authors.initials: Z
authors.lastname: Takci
authors.forename: Pinar
authors.initials: P
authors.lastname: Ozoguz
mesh_terms: D000328:Adult; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D009260:Nail Diseases / Q000139:chemically induced*; D010858:Pigmentation / Q000187:drug effects; D019851:Thrombophilia / Q000188:drug therapy; D000078222:Tinzaparin
chemical_list: D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin