title: [Effect of Shuxuetong injection on neuron-specific enolase of serum and recovery of function in patients with acute cerebral infarction].
abstract: OBJECTIVE
  To observe the clinical effect and the influences of Shuxuetong injection on serum neuron-specific enolase (NSE) level, the neurological deficit and activities of daily living in patients with acute cerebral infarction.
  
  
  METHODS
  The 80 patients with acute cerebral infarction were randomly divided into Shuxuetong treatment group (40 cases) and routine control group (40 cases), both received routine treatment, while Shuxuetong injection was given additionally to treatment group. The serum NSE level, the National Insitute of Health Stroke Scale (NIHSS) scores and the clinical effect were observed pre-and post-treatment. The Barthel Index (BI) was evaluated after one month.
  
  
  RESULTS
  The serum NSE level and NIHSS scores in two groups of post-treatment decreased obviously than those of pre-treatment, and after treatment in Shuxuetong treatment group the serum NSE level and NIHSS scores were significantly lower than those in control group, the differences were significant (P<0.05). Effective rate of Shuxuetong treatment group was 87.5%, and control group was 65%, the difference of the clinical effect between the two groups was significance (P<0.05). After one month BI of post-treatment in two groups improved than those of pre-treatment, and Shuxuetong treatment group was significantly better compared with control group (P<0.05).
  
  
  CONCLUSIONS
  Shuxuetong injection has the remarkable neuronal protective effect, can decrease the serum level of NSE after acute cerebral infarction, promote recovery of nerve function, reduce disability rate, and improve quality of life and prognosis of patients with acute cerebral infarction.
authors.affiliation: The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, China. zhuhaizhenjun@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Zhen
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Kong
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Kou
authors.forename: Hanwei
authors.initials: H
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood* / Q000187:drug effects; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C532053:shuxuetong; D010751:Phosphopyruvate Hydratase