title: Chemical and biological evaluation of some new antipyrine derivatives with particular properties.
abstract: Starting from 4-amino-antipyrine, six new compounds were synthesized and characterized. The new compounds contain moieties with particular properties, such are ionophore (benzo-15-crown-5), fluorescent (nitrobenzofurazan), stable free radical (nitroxide), or other types of biological active residues, like nitroderivatives, antipyrine or isoniazid residues. They were fully characterized by appropriate means ((1)H and (13)C NMR, IR, UV-Vis, fluorescence, EPR, elemental analysis) and some of their biological properties were evaluated. Hydrophobicity (R(M0), log P), total antioxidant capacity (TAC), and antimicrobial properties are also presented and discussed.
authors.affiliation: University of Bucharest, Department of Chemistry, Biochemistry and Catalysis, 90-92 Panduri, Bucharest 050663, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Remes
authors.forename: A
authors.initials: A
authors.lastname: Paun
authors.forename: I
authors.initials: I
authors.lastname: Zarafu
authors.forename: M
authors.initials: M
authors.lastname: Tudose
authors.forename: M T
authors.initials: MT
authors.lastname: Caproiu
authors.forename: G
authors.initials: G
authors.lastname: Ionita
authors.forename: C
authors.initials: C
authors.lastname: Bleotu
authors.forename: L
authors.initials: L
authors.lastname: Matei
authors.forename: P
authors.initials: P
authors.lastname: Ionita
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D047069:Pyrazolones; D000983:Antipyrine