title: Plasma adrenomedullin concentration in dogs with myxomatous mitral valvular disease.
abstract: Adrenomedullin (AM), a peptide identified to have vasodilating and natriuretic effects, is involved in the regulation of the cardiovascular system. To evaluate plasma AM concentration in dogs with myxomatous mitral valvular disease (MMVD), and to investigate the associations between the concentrations of plasma AM and natriuretic peptides and the echocardiographic data, we evaluated plasma AM concentrations in 31 healthy control dogs and 57 dogs with MMVD. Plasma AM concentrations in dogs with MMVD were higher than that in the control subjects. The plasma AM concentration increased in conjunction with the severity of heart failure according to the International Small Animal Cardiac Health Council (ISACHC). The AM concentrations were 25.1 ± 5.0 fmol/ml (ISACHC class Ia), 29.9 ± 11.0 fmol/ml (ISACHC class Ib), 43.4 ± 19.8 fmol/ml (ISACHC class II) and 73.5 ± 21.7 fmol/ml (ISACHC class III) and 7.5 ± 5.1 fmol/ml (control group), respectively. The receiver operating characteristic curve indicated an area of 0.93 (95% CI, 0.8801-0.9889; <0.0001), a cutoff value of 30.5 fmol/ml, a sensitivity of 87.1%, and a specificity of 82.5% for the determination of congestive heart failure. Plasma AM concentrations correlated with atrial natriuretic peptide concentrations, LA/Ao ratio, and left ventricular diameter. In conclusion, AM may be a potential diagnostic marker for canine MMVD and possibly plays a pathophysiological role in collaboration with the other neurohumoral factors such as natriuretic peptides.
authors.affiliation: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. nkanno@cc.miyazaki-u.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kanno
authors.forename: Kazushi
authors.initials: K
authors.lastname: Asano
authors.forename: Kenji
authors.initials: K
authors.lastname: Teshima
authors.forename: Mamiko
authors.initials: M
authors.lastname: Seki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Edamura
authors.forename: Masami
authors.initials: M
authors.lastname: Uechi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000367:Age Factors; D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004452:Echocardiography; D005260:Female; D016014:Linear Models; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000662:veterinary*; D045265:Natriuretic Peptides / Q000097:blood; D012372:ROC Curve; D013045:Species Specificity
chemical_list: D045265:Natriuretic Peptides; D053607:Adrenomedullin