title: Hybrid liposomes affect cellular lipid constituents and caveolae structures.
abstract: We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
authors.affiliation: Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Ke
authors.initials: K
authors.lastname: Cao
authors.forename: Kouji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Komizu
authors.forename: Keiko
authors.initials: K
authors.lastname: Tamiya-Koizumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Murate
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kyogashima
authors.forename: Jiro
authors.initials: J
authors.lastname: Usukura
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Motoshi
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D017209:Apoptosis; D021941:Caveolae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008954:Models, Biological; D009369:Neoplasms / Q000737:chemistry*; D015398:Signal Transduction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D008055:Lipids; D008081:Liposomes