title: The GM-CSF receptor family: mechanism of activation and implications for disease.
abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple signaling pathways that control key functions such as cell survival, cell proliferation, and functional activation. Understanding the molecular composition of these pathways, the interaction of the various components as well as the kinetics and dose-dependent mechanics of receptor activation provides valuable insights into the function of GM-CSF as well as the related cytokines, interleukin-3 and interleukin-5. This knowledge provides opportunities for the development of new therapies to block the action of these cytokines in hematological malignancy and chronic inflammation.
authors.affiliation: Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Hercus
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Broughton
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ekert
authors.forename: Hayley S
authors.initials: HS
authors.lastname: Ramshaw
authors.forename: Michelle
authors.initials: M
authors.lastname: Perugini
authors.forename: Michele
authors.initials: M
authors.lastname: Grimbaldeston
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Woodcock
authors.forename: Daniel
authors.initials: D
authors.lastname: Thomas
authors.forename: Stuart
authors.initials: S
authors.lastname: Pitson
authors.forename: Timothy
authors.initials: T
authors.lastname: Hughes
authors.forename: Richard J
authors.initials: RJ
authors.lastname: D'Andrea
authors.forename: Michael W
authors.initials: MW
authors.lastname: Parker
authors.forename: Angel F
authors.initials: AF
authors.lastname: Lopez
mesh_terms: D002908:Chronic Disease; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor