title: Focus issue: Wnt and β-catenin signaling in development and disease.
abstract: The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes descriptions of a proapoptotic function for Wnt signaling in melanoma, an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and a noncanonical role for Wnt in neuronal guidance.
authors.affiliation: Editor of Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. ngough@aaas.org
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin