title: Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice.
abstract: Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.
authors.affiliation: Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya, Japan The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes, Meijo University, Nagoya, Japan Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
authors.forename: Takenao
authors.initials: T
authors.lastname: Koseki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mouri
authors.forename: Shizuka
authors.initials: S
authors.lastname: Suzuki
authors.forename: Azusa
authors.initials: A
authors.lastname: Nakajima
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Mamiya
authors.forename: Yijin
authors.initials: Y
authors.lastname: Yan
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
mesh_terms: D019969:Amphetamine-Related Disorders / Q000517:prevention & control; D000704:Analysis of Variance; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant; D003463:Cues; D004305:Dose-Response Relationship, Drug; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D005702:Galantamine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008124:Locomotion / Q000187:drug effects; D008694:Methamphetamine / Q000008:administration & dosage*; D051379:Mice; D009714:Nucleus Accumbens / Q000187:drug effects; D055502:Secondary Prevention; D012646:Self Administration / Q000706:statistics & numerical data
chemical_list: D000697:Central Nervous System Stimulants; D002800:Cholinesterase Inhibitors; D005702:Galantamine; D008694:Methamphetamine