title: Dietary supplementation with conjugated linoleic acid plus n-3 polyunsaturated fatty acid increases food intake and brown adipose tissue in rats.
abstract: The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
authors.affiliation: Vascular Health Programme, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK. a.sneddon@abdn.ac.uk
authors.forename: Alan A
authors.initials: AA
authors.lastname: Sneddon
authors.forename: D Vernon
authors.initials: DV
authors.lastname: Rayner
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Mitchell
authors.forename: Shabina
authors.initials: S
authors.lastname: Bashir
authors.forename: Jung-Heun
authors.initials: JH
authors.lastname: Ha
authors.forename: Klaus W
authors.initials: KW
authors.lastname: Wahle
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Morris
authors.forename: Lynda M
authors.initials: LM
authors.lastname: Williams
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001786:Blood Glucose; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D009124:Muscle Proteins