title: A clean procedure for synthesis of pyrido[d]pyrimidine derivatives under solvent-free conditions catalyzed by ZrO(2) nanoparticles.
abstract: A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3- d]pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an efficient heterogeneous catalyst is described. The procedure has the advantages of high yields (86-97%), short reaction time (2h) and an environmentally friendly specificity.
authors.affiliation: Department of Chemistry, East Tehran Branch, Islamic Azad University, Tehran, Iran. abdolmohamadi_sh@yahoo.com
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Abdolmohammadi
authors.forename: Saeed
authors.initials: S
authors.lastname: Balalaie
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
chemical_list: D009570:Nitriles; D011743:Pyrimidines; D012997:Solvents; D014498:Uracil; C044442:5-(4-chlorobenzyl)-6-aminouracil; D015040:Zirconium; C000945:dicyanmethane; C028541:zirconium oxide