title: Neuropilin signalling in angiogenesis.
abstract: VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. The present review outlines the current understanding of NRPs in relation to blood and lymphatic vessel biology.
authors.affiliation: Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185 Uppsala, Sweden. Sina.Koch@mpi-dortmund.mpg.de
authors.forename: Sina
authors.initials: S
authors.lastname: Koch
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism; D018919:Neovascularization, Physiologic; D039921:Neuropilins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D039921:Neuropilins; D020033:Protein Isoforms; D042461:Vascular Endothelial Growth Factor A