title: Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake.
abstract: Physiological and biochemical responses in kidneys of fishes with different trophic levels to toxic cyanobacterial blooms were studied. We sampled four fishes: the phytoplanktivorous Hypophthalmichthys molitrix and Aristichthys nobilis, the omnivorous Carassius auratus, and the carnivorous Culter ilishaeformis. Alterations of the antioxidant (GSH) and the major antioxidant enzymes (CAT, SOD, GPx, GST) were monitored monthly. Catalase and glutathione S-transferase were significantly higher during blooms than before and after blooms. All fishes showed ultrastructural alterations during blooms, which mainly are inosculation of foot processes in epithelial cell of glomeruli and mitochondria swelling in the proximal tubules. The results suggested that kidney impairment from chronic exposure of toxic cyanobacterial blooms might be the first step, and then followed by hepatic failure. Compared with livers in terms of physiological status, the weaker antioxidant ability of kidney made it more susceptible to chronic MCs exposure, besides its effective accumulation of MC metabolites.
authors.affiliation: Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430072, PR China.
authors.forename: Tong
authors.initials: T
authors.lastname: Qiu
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Longgen
authors.initials: L
authors.lastname: Guo
authors.forename: Dawen
authors.initials: D
authors.lastname: Zhang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002347:Carps / Q000382:microbiology; D002374:Catalase / Q000378:metabolism; D002681:China; D000458:Cyanobacteria / Q000254:growth & development / Q000472:pathogenicity*; D004784:Environmental Monitoring / Q000379:methods; D005393:Fish Diseases / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D029941:Fish Proteins / Q000378:metabolism; D005399:Fishes / Q000378:metabolism / Q000382:microbiology*; D005618:Fresh Water / Q000382:microbiology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000382:microbiology; D057097:Harmful Algal Bloom; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000382:microbiology* / Q000648:ultrastructure; D007674:Kidney Diseases / Q000378:metabolism / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D017093:Liver Failure / Q000382:microbiology / Q000662:veterinary; D015999:Multivariate Analysis; D018570:Risk Assessment; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014871:Water Microbiology
chemical_list: D015415:Biomarkers; D029941:Fish Proteins; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione