title: Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection.
abstract: IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Joshita
authors.forename: Takeji
authors.initials: T
authors.lastname: Umemura
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kimura
authors.forename: Susumu
authors.initials: S
authors.lastname: Morita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kamijo
authors.forename: Michiharu
authors.initials: M
authors.lastname: Komatsu
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ichijo
authors.forename: Akihiro
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Kaname
authors.initials: K
authors.lastname: Yoshizawa
authors.forename: Nozomi
authors.initials: N
authors.lastname: Kamijo
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D007564:Japan; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda