title: Tumour necrosis factor-α-857T allele reduces the risk of hepatitis B virus infection in an Asian population.
abstract: Tumour necrosis factor-α (TNF-α) plays a pivotal role in hepatitis B virus (HBV) clearance and host immune response determining the chronicity of HBV infection. However, studies of the association between TNF-α-857 polymorphism and chronic HBV infection have reported conflicting results. So a meta-analysis was carried out to draw a more precise conclusion. Pubmed (January, 1966-March, 2011) and the China Biological Medicine Database (January, 1978-March, 2011) were searched using the keywords TNF-α gene polymorphism in combination with HBV infection without language restriction. Fourteen studies including 4929 chronic HBV infection cases and 2702 controls describing the C857T genotype were included in the meta-analysis. All fourteen studies focussed on an Asian population. The overall meta-analysis suggested that TNF-α-857T allele reduced the risk of chronic HBV infection in the Asian population (OR = 0.82, 95% CI: 0.71-0.95, P = 0.008) when compared with a spontaneously recovered population. In the sensitivity analyses of the groups obeying Hardy-Weinberg equilibrium (HWE), without the largest study population and without the smallest study population, a similar association was revealed (OR = 0.81, 95% CI: 0.68-0.98, P = 0.043; OR = 0.77, 95% CI: 0.68-0.87, P = 0.0001; OR = 0.81, 95% CI: 0.70-0.95, P = 0.009, respectively). However, when compared with a healthy population, no significant association was found in the Asian population in all groups. So, we draw the conclusion that the TNF-α-857T allele reduces the risk of chronic HBV infection in this Asian population.
authors.affiliation: Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.
authors.forename: K-Q
authors.initials: KQ
authors.lastname: Shi
authors.forename: X-H
authors.initials: XH
authors.lastname: Cai
authors.forename: D-D
authors.initials: DD
authors.lastname: Xiao
authors.forename: S-J
authors.initials: SJ
authors.lastname: Wu
authors.forename: M-M
authors.initials: MM
authors.lastname: Peng
authors.forename: X-F
authors.initials: XF
authors.lastname: Lin
authors.forename: W-Y
authors.initials: WY
authors.lastname: Liu
authors.forename: Y-C
authors.initials: YC
authors.lastname: Fan
authors.forename: Y-P
authors.initials: YP
authors.lastname: Chen
authors.forename: M-H
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D060467:Disease Resistance; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000276:immunology; D006801:Humans; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology
chemical_list: D014409:Tumor Necrosis Factor-alpha