title: PAS kinase: integrating nutrient sensing with nutrient partitioning.
abstract: Recent data suggests that PAS kinase acts as a signal integrator to adjust metabolic behavior in response to nutrient conditions. Specifically, PAS kinase controls the partitioning of nutrient resources between the myriad of possible fates. In this capacity, PAS kinase elicits a pro-growth program, which includes both signaling and metabolic control, both in yeast and in mammals. We propose that, like other kinases possessing these properties-AMPK and TOR, PAS kinase might be target for therapy of diabetes, obesity and cancer.
authors.affiliation: Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, United States.
authors.forename: Caleb M
authors.initials: CM
authors.lastname: Cardon
authors.forename: Jared
authors.initials: J
authors.lastname: Rutter
mesh_terms: D000818:Animals; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D051379:Mice; D009747:Nutritional Physiological Phenomena; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: C116037:PAS domain kinases; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases