title: Decrease in size of non-treated lesions after cryoablation for hepatocellular carcinoma.
abstract: We present the case of one 58-year-old man with advancd hepatocellular carcinoma and hepatitis-B virus-related liver cirrhosis who received hepatic cryoablation. Magnetic resonance imaging (MRI) showed multiple liver tumors and the diameter of the largest tumor was more than 10cm. The patient received 2 percutaneous cryoablations in December 2009 and January 2010. Ten months later, MRI showed that not only the treated areas underwent necrosis but also the non-treated area decreased. The a-fetoprotein (AFP) level and the frequency of circulated regulatory T cell (Treg) before treatment were 13,800ng/mL and 15.6%, respectively. Following the cryoablations they dropped to 436ng/mL and 7.6%, respectively, 10 months later. The patient remains in good condition until now.
authors.affiliation: Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Wang
authors.forename: Yin-Ying
authors.initials: YY
authors.lastname: Lu
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Bai
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Qu
authors.forename: Min
authors.initials: M
authors.lastname: Lou
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zeng
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Chang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Yang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D003452:Cryosurgery; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D018655:Lymphocyte Count; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C097353:AFP protein, human; D000509:alpha-Fetoproteins