title: Study of anti-inflammatory effects of GB-115, a glycine-containing retropeptide cholecystokinin analog.
abstract: Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Shipaeva
authors.forename: L P
authors.initials: LP
authors.lastname: Kovalenko
authors.forename: A V
authors.initials: AV
authors.lastname: Sorokina
authors.forename: G I
authors.initials: GI
authors.lastname: Kovalev
authors.forename: A V
authors.initials: AV
authors.lastname: Tallerova
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002351:Carrageenan / Q000009:adverse effects / Q000494:pharmacology; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003208:Concanavalin A / Q000009:adverse effects / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D020556:Neutrophil Infiltration / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D004151:Dipeptides; C520797:GB-115; D017382:Reactive Oxygen Species; D003208:Concanavalin A; D002351:Carrageenan; D002766:Cholecystokinin