title: Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline.
abstract: The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective α-aminoxylation of aldehydes is described. The system allows the easy preparation of a series of β-aminoxy alcohols (after a reductive workup) with excellent optical purity and with an effective catalyst loading of ca. 2.5% (four-fold reduction compared to the batch process) working at residence times of ca. 5 min.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ). Avda. Països Catalans, 16. E-43007, Tarragona, Spain.
authors.forename: Xacobe C
authors.initials: XC
authors.lastname: Cambeiro
authors.forename: Rafael
authors.initials: R
authors.lastname: Martín-Rapún
authors.forename: Pedro O
authors.initials: PO
authors.lastname: Miranda
authors.forename: Sonia
authors.initials: S
authors.lastname: Sayalero
authors.forename: Esther
authors.initials: E
authors.lastname: Alza
authors.forename: Patricia
authors.initials: P
authors.lastname: Llanes
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs