title: Emergence of a new HIV type 1 CRF01_AE variant in Guangxi, Southern China.
abstract: The distribution of HIV-1 subtypes and genetic characterization of CRF01_AE in Guangxi, southern China were identified. The distribution of HIV-1 genotypes based on gag, pol, and partial env sequences (n=349) was as follows: CRF01_AE (66.5%), CRF08_BC (19.2%), CRF07_BC (7.2%), URF (4.6%), subtype B (1.7%), and subtype B' (0.9%). CRF01_AE predominated in all geographic regions and risk populations and there were multiple introductions of CRF01_AE strains in Guangxi. We found a peculiar CRF01_AE monophyletic lineage distinct from other CRF01_AE viruses, and we designated it "CRF01_AE-v" for convenience. CRF01_AE-v circulating in both heterosexuals and injecting drug users (IDUs) had accounted for 39.7% of CRF01_AE. It showed a selective advantage in the Guangxi population and formed its own characteristic compared with all the CRF01_AE references. Our results suggested that CRF01_AE-v was a new variant of CRF01_AE and it might lead to a new epidemic in Guangxi.
authors.affiliation: Research Group of HIV Molecular Epidemiology and Virology, The State Key Laboratory of Virology, Wuhan Institution of Virology, Chinese Academy of Sciences, Hubei, The People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zeng
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Sun
authors.forename: Shujia
authors.initials: S
authors.lastname: Liang
authors.forename: Lingnuo
authors.initials: L
authors.lastname: Li
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Binlian
authors.initials: B
authors.lastname: Sun
authors.forename: Jingyun
authors.initials: J
authors.lastname: Li
authors.forename: Rongge
authors.initials: R
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D015752:Genes, env / Q000235:genetics*; D015750:Genes, gag / Q000235:genetics*; D015751:Genes, pol / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D011247:Pregnancy; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D055815:Young Adult