title: The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
abstract: Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkB(F616A) mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (∽32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function.
authors.affiliation: Department of Anesthesiology, College of Medicine, Mayo Clinic, 200 First Street SW, Joseph 4W-184F, Rochester, Minnesota 55905, USA. mantilla.carlos@mayo.edu
authors.forename: Carlos B
authors.initials: CB
authors.lastname: Mantilla
authors.forename: Leonid G
authors.initials: LG
authors.lastname: Ermilov
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000166:cytology; D004558:Electric Stimulation; D047309:Flavones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000235:genetics; D020813:Receptor, trkB / Q000819:agonists* / Q000235:genetics; D013997:Time Factors
chemical_list: C485383:6,7-dihydroxyflavone; D047309:Flavones; D020813:Receptor, trkB