title: Vitamin A metabolism and adipose tissue biology.
abstract: In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
authors.affiliation: Department of Medicine and the Institute of Human Nutrition, Columbia University, New York, NY 10032, USA. mail@simonefrey.de
authors.forename: Simone K
authors.initials: SK
authors.lastname: Frey
authors.forename: Silke
authors.initials: S
authors.lastname: Vogel
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000818:Animals; D051379:Mice; D018345:Mice, Knockout; D051381:Rats; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D054840:Retinol-Binding Proteins, Cellular / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism*
chemical_list: D018168:Receptors, Retinoic Acid; D054840:Retinol-Binding Proteins, Cellular; D014801:Vitamin A; D014212:Tretinoin