title: CYFRA 21-1 as a tool for distant metastasis detection in lung cancer.
abstract: BACKGROUND
  A study to analyse tumor markers (CEA, CA125, CA15.3, CA19.9, CYFRA 21-1, and NSE) for metastasis detection in lung cancer patients.
  
  
  METHODS
  Serum tumor markers from 73 lung cancer patients were measured before they were diagnosed. After lung cancer diagnosis, tumor markers were analyzed for the detection of distant metastases.
  
  
  RESULTS
  In NSCLC patients CYFRA 21-1 and NSE showed differences between stage IV and any of the other stages, p < 0.05. The accuracy for metastasis detection was AUC = 81.5 % for CYFRA 21-1 and AUC = 78.6 % for < 0.05) were independent predictors for metastasis presence. No tumor marker showed significant differences according to stages in SCLC patients.
  
  
  CONCLUSIONS
  CYFRA 21-1 could be used as a screening tool for metastasis detection in lung cancer patients without symptoms of metastasis as well as CYFRA 21-1 and NSE in NSCLC patients.
authors.affiliation: Department of Clinical Biochemistry, Virgen del Rocio University Hospital, IBIS/CSIC/University of Seville, Avenida Manuel Siurot, Seville, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Cabrera-Alarcon
authors.forename: A
authors.initials: A
authors.lastname: Carrillo-Vico
authors.forename: J D
authors.initials: JD
authors.lastname: Santotoribio
authors.forename: A
authors.initials: A
authors.lastname: Leon-Justel
authors.forename: R
authors.initials: R
authors.lastname: Sanchez-Gil
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez-Castro
authors.forename: J M
authors.initials: JM
authors.lastname: Guerrero
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000556:secondary*; D006801:Humans; D053539:Keratin-19 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D008565:Membrane Proteins / Q000097:blood; D018396:Mucin-1 / Q000097:blood; D009363:Neoplasm Proteins / Q000097:blood; D009367:Neoplasm Staging; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; C451759:MUC16 protein, human; D008565:Membrane Proteins; D018396:Mucin-1; D009363:Neoplasm Proteins; C102012:antigen CYFRA21.1; D010751:Phosphopyruvate Hydratase