title: Morphological characteristics of the central compartment of the erythron in aggressive and indolent non-Hodgkin's lymphomas.
abstract: Structural changes in cells of the central compartment of the erythron depended on tumor infiltration of the bone marrow. Cytostatic therapy was shown to improve quantitative indexes, but had no effect on morphological characteristics of the erythron. Examination of trepanobiopsy specimens from the iliac crest during chemotherapy revealed the existence of specific relationships between the erythron, other cells and tissues of the bone marrow, and tumor. Significant changes in the erythron were found during diffuse tumor infiltration and treatment with anthracycline antibiotics.
authors.affiliation: Laboratory of Molecular, Cellular, and Immunomorphological Bases of Oncohematology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dolgikh
authors.forename: N P
authors.initials: NP
authors.lastname: Domnikova
authors.forename: E E
authors.initials: EE
authors.lastname: Petrusenko
authors.forename: N A
authors.initials: NA
authors.lastname: Mal'tseva
authors.forename: I V
authors.initials: IV
authors.lastname: Kachesov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D002452:Cell Count; D041905:Erythroid Cells / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult