title: A revision of the organ radiation doses from 2-fluoro-2-deoxy-D-glucose with reference to tumour presence.
abstract: Absorbed radiation doses to major human organs after intravenous bolus administration of 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) were reviewed. Absorbed doses were calculated using the medical internal radiation dose (MIRD) formalism from experimental activity-time curves. Thirty patients (22 with macroscopic lung tumour and 8 without observable disease) were investigated using a state-of-the-art combined positron emission tomography/computer tomography system (Siemens Biograph 64). Each patient underwent a series of 10 consecutive whole-body PET scans during the first 60-min post-FDG administration. Differences were observed between organ radiation doses in this work and those reported in International Commission for Radiation Protection 106 (21 % in effective dose). The presence of tumour did not affect the FDG biodistribution. Large inter-individual variations in organ-absorbed doses were observed. This in combination with the lack of a model for bladder voiding suitable for all patients suggests the need for a more precise estimate of normal-organ radiation doses. This will be beneficial in optimising FDG administration in clinical routine.
authors.affiliation: Department of Physics,  Stockholm University, Stockholm,  Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Staaf
authors.forename: Hans
authors.initials: H
authors.lastname: Jacobsson
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sanchez-Crespo
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D011835:Radiation Protection; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18