title: [Comparative study between landiolol and amiodarone for therapeutic efficacy after open heart surgery].
abstract: Tachyarrhythmia, especially atrial fibrillation, remains as a common complication after open heart surgery and sometimes leads to fatal condition. Many reports showed that landiolol (ultra short-acting beta one blocker) and amiodarone were effective against postoperative atrial fibrillation (POAF). However, there were few comparative studies between these 2 drugs as prophylactic agents, and no report mentioned the therapeutic efficacy. Our study suggests that landiolol be the 1st choice for rate control of tachyarrhythmia because of easy dose adjustment and mild side effects. Amiodarone may be useful for the patients whose left ventricular function is poor.
authors.affiliation: Department of Cardiovascular Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Ito
authors.forename: Taisuke
authors.initials: T
authors.lastname: Konishi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imazuru
authors.forename: Kanji
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Jikuya
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D009025:Morpholines / Q000627:therapeutic use*; D011183:Postoperative Complications; D013610:Tachycardia / Q000188:drug therapy* / Q000517:prevention & control; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea; D000638:Amiodarone