title: Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma.
abstract: The capacity for self-renewal is thought to be a critical property of tumor-initiating cells. This capacity is often associated with the ability to generate spheres in vitro. In this issue of Cancer Cell, Barrett et al. show that cells lacking sphere-forming ability can still be very efficient at propagating tumors.
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Tracy-Ann
authors.initials: TA
authors.lastname: Read
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wechsler-Reya