title: Intrathecal baclofen pump: a foreign-body reaction case report and its solution.
abstract: METHODS
  A 43-year-old woman with cerebral palsy and disabling spasticity underwent a series of 4 implantations of intrathecal baclofen pumps, performed by two teams. A history of 3 aseptic local skin reactions over the site of insertion started 4 months after the first insertion, once with partial pump exposure. There were no clinical or biological signs of infection. Skin patch tests were negative. Relocation of the system was followed by a relapse, while removal of the pump was followed each time by complete resolution of the symptoms. Histological findings showed slight mononuclear dermal infiltration without epidermal lesions, which excluded contact dermatitis. Pump intolerance with a foreign-body reaction was diagnosed. A pump wrapped with polyethylene terephthalate was reimplanted. No recurrence of symptoms occurred after a 3-year follow-up period, with improvement in impairment, activity and satisfaction due to intrathecal baclofen therapy.
  
  
  CONCLUSIONS
  A foreign-body reaction after intrathecal baclofen pump implantation is a rare complication, which has not been reported previously, and which is associated with negative skin patch tests. In cases with no signs of infection, skin intolerance must be suspected and dermatological assessments should be carried out. Replacement with a pump wrapped in an inert coating is an effective and available solution.
authors.affiliation: Neurorehabilitation Unit, Leon Berard Hospital, Hyeres, France. bernuzbenjamin@yahoo.fr
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bernuz
authors.forename: Haudrey
authors.initials: H
authors.lastname: Assier
authors.forename: Helene
authors.initials: H
authors.lastname: Bisseriex
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Thiebaut
authors.forename: Celia
authors.initials: C
authors.lastname: Rech
authors.forename: Alexis
authors.initials: A
authors.lastname: Schnitzler
mesh_terms: D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy*; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology*; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D007278:Injections, Spinal
chemical_list: D001418:Baclofen