title: Primary ureteral giant cell sarcoma in a Pomeranian.
abstract: An 8-year-old male neutered Pomeranian dog was presented to the Veterinary Teaching Hospital at Oregon State University for surgical treatment of hydronephrosis of the left kidney and a left cranial abdominal mass. A primary ureteral mass was found during exploratory surgery, and the mass was resected and ureteral anastomosis was performed. Cytologic evaluation of the mass revealed 3 distinct cell populations, including a large number of multinucleated giant cells, a moderate number of thin spindle-shaped cells, and cohesive clusters of transitional epithelial cells. The cytologic diagnosis was giant cell sarcoma. The diagnosis was confirmed by histologic examination, and immunohistochemical staining was performed. The spindle-shaped cells and multinucleated giant cells were both immunoreactive for vimentin and spindle-shaped cells for S-100. Tumor cells did not express wide-spectrum cytokeratin, broad-spectrum muscle actin, smooth muscle actin, sarcomeric actin, desmin, BLA36, Mac 387, synaptophysin, neuron-specific enolase, glial fibrillary acid protein, or von Willebrand factor. These findings are most consistent with an anaplastic sarcoma with giant cells. This is the first case report of a primary ureteral giant cell sarcoma in a dog.
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331-4801, USA. rigasj@vetmed.wsu.edu
authors.forename: Johanna D
authors.initials: JD
authors.lastname: Rigas
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Smith
authors.forename: M Elena
authors.initials: ME
authors.lastname: Gorman
authors.forename: Beth A
authors.initials: BA
authors.lastname: Valentine
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Simpson
authors.forename: Bernard
authors.initials: B
authors.lastname: Seguin
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D008297:Male; D012509:Sarcoma / Q000145:classification / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014516:Ureteral Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*