title: Nutrition strategies to improve physical capabilities in Duchenne muscular dystrophy.
abstract: There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticosteroids. This article describes 2 potential nutritional interventions for the treatment of DMD, green tea extract (GTE) and the branched-chain amino acid leucine, and their positive effects on physical activity. Both GTE and leucine are suitable for human consumption, are easily tolerated with no side effects, and, with appropriate preclinical data, could be brought forward to clinical trials rapidly.
authors.affiliation: Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: J
authors.initials: J
authors.lastname: Davoodi
authors.forename: C D
authors.initials: CD
authors.lastname: Markert
authors.forename: K A
authors.initials: KA
authors.lastname: Voelker
authors.forename: S M
authors.initials: SM
authors.lastname: Hutson
authors.forename: Robert W
authors.initials: RW
authors.lastname: Grange
mesh_terms: D000818:Animals; D028241:Camellia sinensis; D019587:Dietary Supplements; D006801:Humans; D007930:Leucine / Q000627:therapeutic use*; D009043:Motor Activity; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy* / Q000503:physiopathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D058570:TOR Serine-Threonine Kinases; D007930:Leucine