title: [Abdominal compartment syndrome and acute intestinal distress syndrome].
abstract: Seriously ill patients frequently present intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as complications, and the associated mortality is very high. This review offers an update on the most controversial aspects of these entities: factors favoring their appearance, the most common causes, prognosis, and methods of measuring intra-abdominal pressure (IAP), physiopathological consequences in relation to the different organs and systems, and the currently accepted treatment measures (medical and/or surgical). Simultaneously to the strictly physical mechanisms of injury, such as direct compression of intra-abdominal organs and vessels, the transmission of IAP to other compartments, and the drop in cardiac output, a series of immune-inflammatory mediators generated in the intestine itself may also intervene. Hypoperfusion, sustained ischemia and the ischemia-reperfusion phenomenon, would act upon the microbiota, intestinal epithelium and intestinal immune system, triggering a systemic inflammatory response and multiorgan dysfunction that appears in the final stages of ACS.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario San Juan de Alicante, Alicante, España.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Miralles
authors.forename: G
authors.initials: G
authors.lastname: Castellanos
authors.forename: R
authors.initials: R
authors.lastname: Badenes
authors.forename: R
authors.initials: R
authors.lastname: Conejero
mesh_terms: D000208:Acute Disease; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology*; D059325:Intra-Abdominal Hypertension / Q000150:complications* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D013577:Syndrome