title: Vaxcine(TM): an oil-based adjuvant for influenza vaccines.
abstract: Vaccination is the method of choice for the prevention of influenza infection. However, the quantity of the antigen available, especially in the case of pandemics, often fails to meet the global demand. However, improved adjuvants can overcome this problem. Preliminary results obtained in this study revealed that one year after a single subcutaneous immunisation with influenza A H3N2 virus in an oil-based carrier, Vaxcine(TM), outbreed mice produced a high immunoglobulin G response that lasted for up to one year and exhibited less variation in titre compared with the response of the control group treated with alum. The haemagglutination-inhibition titres induced by Vaxcine(TM) were also higher than those generated by alum. These data indicate that Vaxcine(TM) is a good adjuvant candidate for seasonal influenza vaccines.
authors.affiliation: Laboratório de Virologia, Instituto Butantan, São Paulo, SP, Brasil, 05503-900.
authors.forename: Rosely Cabette Barbosa
authors.initials: RC
authors.lastname: Alves
authors.forename: Roger Randal Charles
authors.initials: RR
authors.lastname: New
authors.forename: Gabrielle Ribeiro
authors.initials: GR
authors.lastname: Andrade
authors.forename: Rita Maria Zucatelli
authors.initials: RM
authors.lastname: Mendonça
authors.forename: Osvaldo Augusto Brasil Esteves
authors.initials: OA
authors.lastname: Sant'Anna
authors.forename: Dalva Assunção Portari
authors.initials: DA
authors.lastname: Mancini
authors.forename: Silvio Marciano da
authors.initials: SM
authors.lastname: Silva-Junior
authors.forename: Marta de Oliveira
authors.initials: Mde O
authors.lastname: Domingos
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000627:therapeutic use*; D051379:Mice; D008899:Mineral Oil / Q000627:therapeutic use; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D008899:Mineral Oil