title: Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation.
abstract: A blastocyst will implant only when the uterus becomes receptive. Following attachment, luminal epithelial cells undergo degeneration at the site of the blastocyst. Although many genes critical for uterine receptivity are primarily regulated by ovarian hormones, Kruppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is persistently expressed in epithelial cells independently of ovarian hormones. Loss of uterine Klf5 causes female infertility due to defective implantation. Cox2 is normally expressed in the luminal epithelium and stroma at the site of blastocyst attachment, but luminal epithelial COX2 expression is absent with loss of Klf5. This is associated with the retention of the epithelium around the implantation chamber with arrested embryonic growth. These results suggest that Klf5 is indispensable for normal implantation.
authors.affiliation: Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Sun
authors.forename: Liqian
authors.initials: L
authors.lastname: Zhang
authors.forename: Huirong
authors.initials: H
authors.lastname: Xie
authors.forename: Huajing
authors.initials: H
authors.lastname: Wan
authors.forename: Bliss
authors.initials: B
authors.lastname: Magella
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Whitsett
authors.forename: Sudhansu K
authors.initials: SK
authors.lastname: Dey
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism*; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D008156:Luciferases; D051379:Mice; D014162:Transfection; D014599:Uterus / Q000378:metabolism*
chemical_list: C118391:Klf5 protein, mouse; D051741:Kruppel-Like Transcription Factors; D008156:Luciferases