title: [A case of bile duct cancer with positive surgical margin obtaining long-term survival after S-1 monotherapy].
abstract: We report a case of bile duct cancer with a positive surgical margin obtaining long-term survival after S-1 monotherapy. A 79-year-old male with fever and liver dysfunction was admitted to our hospital. After a series of examinations he was diagnosed as hilar cholangiocarcinoma, which was treated with bile duct resection and biliary reconstruction for adhesion and pulmonary dysfunction of tuberculosis. Histopathological findings revealed that both surgical margins of the bile duct were positive. After operation, the patient received S-1 oral monotherapy(100mg/day for 28 days, followed by 14 days of rest)for 3 years. The patient has been alive for 5 years without recurrence.
authors.affiliation: Dept. of Surgery, Hachioji Digestive Disease Hospital.
authors.forename: Shuji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Morishita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kaji
authors.forename: Nobusada
authors.initials: N
authors.lastname: Koike
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Takeo
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Harada
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Hayashi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Toshihide
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid