title: Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals.
abstract: Although persistent inflammation has been related to unsuccessful aging, a pro-inflammatory status is the common phenotype in older people. To assess for a genetic component in the inflammatory status of the oldest we studied the distribution of two polymorphic chemokine pathway genes, RANTES and CCR5, in elderly. RANTES -403G/A and RANTES Int1.1T/C polymorphisms and CCR5Δ32 polymorphism were genotyped in 104 elderly and 110 controls. RANTES -403A and RANTES Int1.1C alleles have been associated with pro-inflammatory and anti-inflammatory status, respectively. CCR5Δ32 abrogates functional receptor expression of the pro-inflammatory CCR5-mediated action. Prevalence of RANTES -403G allele, associated in other studies with high RANTES production, was reduced in elderly males, compared with controls. In addition, RANTES pro-inflammatory haplotype -403A-Int1.1T was overrepresented in elderly males, while RANTES anti-inflammatory haplotype -403G-Int1.1C was overrepresented in elderly females. Our results suggest a sex-specific RANTES inflammatory genetic determinant that could contribute to the known sex-related differences in aging.
authors.affiliation: Departament de Ciències Mèdiques Bàsiques, Unitat de Genètica Humana, IRBLleida, Universitat de Lleida, C/ Montserrat Roig, 2. 25008 Lleida, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Laplana
authors.forename: Joan
authors.initials: J
authors.lastname: Fibla
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D018946:Chemokine CCL5 / Q000235:genetics*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008136:Longevity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D018946:Chemokine CCL5; D019713:Receptors, CCR5