title: Antioxidant properties and neuroprotective capacity of strawberry tree fruit (Arbutus unedo).
abstract: Berries contain significant amounts of phytochemicals, including polyphenols, which are reported to reduce cancer risk, coronary heart disease and other degenerative diseases. These effects are mainly attributed to the antioxidant capacity of polyphenols found in berries. Strawberry tree (Arbutus unedo) berries are used in folk medicine but seldom eaten as fresh fruits. Their phenolic profile and antioxidant capacity reveal a high potential, but they are not well characterized as a "health promoting food". The aim of this study was to assess the antioxidant properties of the edible strawberry tree fruit in vitro and in a neurodegeneration cell model. Raspberry (Rubus idaeus), a well documented health-promoting fruit, was used as a control for comparison purposes. A. unedo yielded a similar content in polyphenols and a slightly lower value of total antioxidant capacity in comparison to R. idaeus. Although the chemically-measured antioxidant activity was similar between both fruits, R. idaeus increased neuroblastoma survival in a neurodegeneration cell model by 36.6% whereas A. unedo extracts caused no effect on neuroblastoma viability. These results clearly demonstrate that a promising level of chemically-determined antioxidant activity of a plant extract is not necessarily correlated with biological significance, as assessed by the effect of A. unedo fruit in a neurodegeneration cell model.
authors.affiliation: Disease & Stress Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal. fortalezas@itqb.unl.pt
authors.forename: Sofia
authors.initials: S
authors.lastname: Fortalezas
authors.forename: Lucélia
authors.initials: L
authors.lastname: Tavares
authors.forename: Rui
authors.initials: R
authors.lastname: Pimpão
authors.forename: Meenu
authors.initials: M
authors.lastname: Tyagi
authors.forename: Vera
authors.initials: V
authors.lastname: Pontes
authors.forename: Paula M
authors.initials: PM
authors.lastname: Alves
authors.forename: Gordon
authors.initials: G
authors.lastname: McDougall
authors.forename: Derek
authors.initials: D
authors.lastname: Stewart
authors.forename: Ricardo B
authors.initials: RB
authors.lastname: Ferreira
authors.forename: Cláudia N
authors.initials: CN
authors.lastname: Santos
mesh_terms: D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D009447:Neuroblastoma / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts