title: Inflammasomes in health and disease.
abstract: Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases.
authors.affiliation: Department of Immunobiology, Yale University, Connecticut 06520, USA.
authors.forename: Till
authors.initials: T
authors.lastname: Strowig
authors.forename: Jorge
authors.initials: J
authors.lastname: Henao-Mejia
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.forename: Richard
authors.initials: R
authors.lastname: Flavell
mesh_terms: D020170:Caspase 1 / Q000378:metabolism; D004194:Disease; D006262:Health; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology; D058847:Inflammasomes / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D024821:Metabolic Syndrome / Q000378:metabolism / Q000473:pathology
chemical_list: D058847:Inflammasomes; D020170:Caspase 1