title: Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy.
abstract: BACKGROUND
  We sought to determine whether 18- to 22-mo neurodevelopmental outcomes predicted functional outcomes at 7-8 y for survivors of the CoolCap study of therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy.
  
  
  RESULTS
  WeeFIM ratings were completed at 7-8 y of age on 62 (32 cooled; 30 standard care) of 135 surviving children who had had neurodevelopmental assessment at 18 mo. There was 1 refusal, 58 lost to follow-up, and 14 children whose centers declined to participate. Disability status at 18 mo was strongly associated with WeeFIM ratings (P < 0.001); there was no significant effect of treatment (P = 0.83).
  
  
  CONCLUSIONS
  Functional outcome at 7-8 y of survivors of neonatal encephalopathy is associated with 18-mo neurodevelopmental assessment, supporting the long-term predictive value of a favorable outcome at 18 mo assessed by published trials of therapeutic hypothermia.
  
  
  METHODS
  All surviving children who participated in the CoolCap study and were assessed at 18 mo were eligible for reassessment using the WeeFIM instrument that qualitatively measures self-care, mobility, and cognitive function. Center investigators obtained consent from the families for a certified researcher to administer the WeeFIM instrument by phone.
authors.affiliation: Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA. ronnie_guillet@urmc.rochester.edu
authors.forename: Ronnie
authors.initials: R
authors.lastname: Guillet
authors.forename: A David
authors.initials: AD
authors.lastname: Edwards
authors.forename: Marianne
authors.initials: M
authors.lastname: Thoresen
authors.forename: Donna M
authors.initials: DM
authors.lastname: Ferriero
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gluckman
authors.forename: Andrew
authors.initials: A
authors.lastname: Whitelaw
authors.forename: Alistair Jan
authors.initials: AJ
authors.lastname: Gunn
mesh_terms: D000367:Age Factors; D002648:Child; D002657:Child Development; D003071:Cognition; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000401:mortality / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009048:Motor Skills; D009483:Neuropsychological Tests; D009520:New Zealand; D011237:Predictive Value of Tests; D012648:Self Care; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D006113:United Kingdom; D014481:United States