title: Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.
abstract: Methods on rendering neurons in the central nervous system to be light responsive has led to a boom in using optical neuromodulation as a new approach for controlling brain states and understanding neural circuits. In addition to the developing versatility to "optogenetically" labeling of neural cells and their subtypes by microbiological methods, parallel efforts are under way to design and implement optoelectronic devices to achieve simultaneous optical neuromodulation and electrophysiological recording with high spatial and temporal resolution. Such new device-based technologies need to be developed for full exploitation of the promise of optogenetics. In this paper we present single- and multi-element optoelectronic devices developed in our laboratories. The single-unit element, namely the coaxial optrode, was utilized to characterize the neural responses in optogenetically modified rodent and primate models. Furthermore, the multi-element device, integrating the optrode with a 6×6 microelectrode array, was used to characterize the spatiotemporal spread of neural activity in response to single-site optical stimulation in freely moving rats. We suggest that the particular approaches we employed can lead to the emergence of methods where spatio-temporal optical modulation is integrated with real-time read out from neural populations.
authors.affiliation: Department of Physics, School of Engineering.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Ilker
authors.initials: I
authors.lastname: Ozden
authors.forename: Mohamed
authors.initials: M
authors.lastname: Diagne
authors.forename: Fabien
authors.initials: F
authors.lastname: Wagner
authors.forename: David
authors.initials: D
authors.lastname: Borton
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brush
authors.forename: Naubahar
authors.initials: N
authors.lastname: Agha
authors.forename: Rebecca
authors.initials: R
authors.lastname: Burwell
authors.forename: David
authors.initials: D
authors.lastname: Sheinberg
authors.forename: Ilka
authors.initials: I
authors.lastname: Diester
authors.forename: Karl
authors.initials: K
authors.lastname: Deisseroth
authors.forename: Arto
authors.initials: A
authors.lastname: Nurmikko
mesh_terms: D000200:Action Potentials / Q000528:radiation effects; D000818:Animals; D004581:Electronics / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D008027:Light; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology / Q000528:radiation effects; D018377:Neurotransmitter Agents / Q000378:metabolism*; D055095:Optics and Photonics / Q000295:instrumentation* / Q000379:methods*; D011323:Primates / Q000502:physiology*; D051381:Rats; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents