title: Time to reflect on surgery and neuro-intervention for intracranial atherosclerotic diseases.
abstract: In view of the early results and halt of recruitment from both the Carotid Occlusion Surgery Study (COSS) and Stenting and the Aggressive Medical Therapy for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study we should seize this opportunity to reflect on future directions, rather than abandoning these procedures, during this period of disillusionment. We here suggest the reasons for the failure of these two clinical trials and review future directions for researche in cerebral revascularization.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, 4/F, Clinical Science Building, The Chinese University of Hong Kong, 1 Ngan Shing Street, Shatin, New Territories, Hong Kong, China. georgewong@surgery.cuhk.edu.hk
authors.forename: George Kwok Chu
authors.initials: GK
authors.lastname: Wong
authors.forename: Wai Sang
authors.initials: WS
authors.lastname: Poon
mesh_terms: D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000601:surgery; D016893:Carotid Stenosis / Q000175:diagnosis / Q000601:surgery; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis* / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D015607:Stents; D020521:Stroke / Q000175:diagnosis / Q000601:surgery