title: Effect of zinc chloride on picrotoxin-induced hyperkinesis depends on its concentration in solution injected into rat neostriatum.
abstract: The hyperkinekic effect (increase in spontaneous activity and development of choreomyoclonic hyperkinesis of the extremities and body) of picrotoxin injected into the rostral neostriatum of rats in a dose of 2 μg was reduced if the drug was injected together with ZnCl(2) in a concentration of 0.1 μg/μl. ZnCl(2) in a concentration of 1 μg/μl did not modulate the effects of picrotoxin, while in a concentration of 3 μg/μl it increased spontaneous motor activity in the open field test without affecting the symptoms of choreomyoclonic hyperkinesis.
authors.affiliation: Department of Normal Physiology, St. Petersburg State I. P. Pavlov Medical University, St. Petersburg, Russia. jakim@spmu.rssi.ru
authors.forename: A F
authors.initials: AF
authors.lastname: Yakimovskii
authors.forename: I I
authors.initials: II
authors.lastname: Stepanov
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D004357:Drug Synergism; D018756:GABA Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D017072:Neostriatum / Q000187:drug effects*; D010852:Picrotoxin / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017967:Zinc Compounds / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D018756:GABA Antagonists; D010852:Picrotoxin; D017967:Zinc Compounds; C016837:zinc chloride