title: Iodine-mediated regioselective C2-amination of indoles and a concise total synthesis of (±)-folicanthine.
abstract: Highly substituted 2-aminated indoles can be prepared in moderate to excellent yields by regioselective C2-amination of indoles promoted by iodine. As a key step in a concise synthesis of (±)-folicanthine, its core structure was easily obtained by one step cyclization-dimerization of substituted tryptophan in high yield on a gram scale.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Ying-Xiu
authors.initials: YX
authors.lastname: Li
authors.forename: Hai-Xi
authors.initials: HX
authors.lastname: Wang
authors.forename: Shaukat
authors.initials: S
authors.lastname: Ali
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Xia
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000586:Amination; D003500:Cyclization; D019281:Dimerization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D011758:Pyrroles; C521485:folicanthine; D007455:Iodine