title: Spectroscopic characterization of an oxovanadium(IV) complex of oxodiacetic acid and o-phenanthroline. Bioactivity on osteoblast-like cells in culture.
abstract: The oxovanadium(IV) complex of oxodiacetic acid (H(2)ODA) and o-phenanthroline of stoichiometry [VO(ODA)(ophen)]·1.5H(2)O, which presents the interesting tridentate OOO coordination, was thoroughly characterized by infrared, Raman, and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast cell lines in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts.
authors.affiliation: Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Ignacio E
authors.initials: IE
authors.lastname: León
authors.forename: Susana B
authors.initials: SB
authors.lastname: Etcheverry
authors.forename: Beatriz S
authors.initials: BS
authors.lastname: Parajón-Costa
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Baran
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D012516:Osteosarcoma / Q000473:pathology; D010618:Phenanthrolines / Q000737:chemistry*; D051381:Rats; D013053:Spectrophotometry / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods; D014638:Vanadates / Q000737:chemistry*
chemical_list: D000085:Acetates; D009942:Organometallic Compounds; D010618:Phenanthrolines; C075743:oxovanadium IV; D014638:Vanadates; C025205:1,10-phenanthroline