title: Prognostic significance of SOX2 expression in nasopharyngeal carcinoma.
abstract: The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein-Barr virus (EBV), remains unclear. Here, we reported that, in the univariate analysis, SOX2 expression was correlated with a poorer distant metastasis-free survival (DMFS). The EBV-VCA/IgA titers in patients with NPC were also associated with a poorer overall survival (OS). Patients with NPC, who had both strong staining of SOX2 and high titers of EBV-VCA/IgA, had the poorest prognoses. Therefore, SOX2 or the combination of the SOX2 expression level and EBV-VCA/IgA titers could be valuable to predict distant metastasis or the prognosis of NPC.
authors.affiliation: State Key Laboratory of Oncology in South China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Xu
authors.forename: Nan
authors.initials: N
authors.lastname: Ge
authors.forename: Rong-Zhen
authors.initials: RZ
authors.lastname: Luo
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Shao
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
authors.forename: Tiebang
authors.initials: T
authors.lastname: Kang
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Yun
authors.forename: Fangyun
authors.initials: F
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000276:immunology; D014408:Biomarkers, Tumor; D036022:Capsid Proteins / Q000276:immunology; D002277:Carcinoma; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009362:Neoplasm Metastasis; D011379:Prognosis; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D000956:Antigens, Viral; D014408:Biomarkers, Tumor; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen; D007070:Immunoglobulin A; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors