title: Enlarged follicles and temporomandibular joint abnormalities in mucolipidosis Type III.
abstract: Mucolipidosis Type III, or pseudo-Hurler polydystrophy, is a rare genetic abnormality, the result of a mutation to one of two genes that encode the hexameric protein N-acetylglucosaminyl-1-phosphotransferase (Glc-NAc-PT). The abnormality results in the accumulation of unprocessed macromolecules in cell and tissue compartments throughout the body. In this case report, we describe the clinical and radiographic findings of a 15-year-old male with this disorder. He presented with bilateral ectopically developing mandibular molar teeth with enlarged follicles and multiple joint involvement, including the temporomandibular joints. The patient underwent surgical removal of the molar teeth and curettage of the associated follicles. The subsequent histopathological examination of the tissues revealed hyperplastic follicles suggestive of dentigerous cysts. This report presents the plain film and cone beam CT examinations of the patient.
authors.affiliation: Discipline of Oral and Maxillofacial Radiology, University of Toronto, Toronto, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Khalifa
authors.forename: H S
authors.initials: HS
authors.lastname: Grubisa
authors.forename: L
authors.initials: L
authors.lastname: Lee
authors.forename: E W N
authors.initials: EW
authors.lastname: Lam
mesh_terms: D000293:Adolescent; D054893:Cone-Beam Computed Tomography / Q000379:methods; D003475:Curettage; D003795:Dental Sac / Q000002:abnormalities* / Q000601:surgery; D003803:Dentigerous Cyst / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging; D008963:Molar / Q000002:abnormalities / Q000601:surgery; D008964:Molar, Third / Q000000981:diagnostic imaging; D009081:Mucolipidoses / Q000000981:diagnostic imaging*; D016300:Radiography, Bitewing; D011862:Radiography, Panoramic; D013704:Temporomandibular Joint / Q000002:abnormalities*; D014079:Tooth Eruption, Ectopic / Q000000981:diagnostic imaging / Q000601:surgery; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000000981:diagnostic imaging