title: Development of a non-heart-beating lung donor program with «Bithermia Preservation», and results after one year of clinical experience.
abstract: The number of lung transplantations that are performed in Spain continues to grow, with 235 transplant recipients 2010. Non-heart-beating donations have contributed to this upward progression. Our Lung Transplant Unit began its activity in October 2008 and during these last three years 97% of the transplant interventions performed have been successful. In order to increase the number of donations, we have developed a non-heart-beating donor program as part of the existing organs program in our hospital. In doing so, the development of a multi-organic preservation method (lung, liver and kidney), which we call «Bithermia Preservation», was necessary. This paper presents this methodology as well as the first year of clinical application experience. During this time, 3 patients have been transplanted using such non-heart-beating donations. None of them developed primary graft dysfunction; all the patients have been discharged and lead active lives without any evidence of bronchiolitis obliterans syndrome.
authors.affiliation: Unidad de Trasplante Pulmonar, Servicio de Cirugía Torácica, Hospital Universitario 12 de Octubre, Madrid, España. antonio.gamez@salud.madrid.org
authors.forename: Pablo
authors.initials: P
authors.lastname: Gámez
authors.forename: Vicente
authors.initials: V
authors.lastname: Díaz-Hellín
authors.forename: Carmen
authors.initials: C
authors.lastname: Marrón
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Meneses
authors.forename: Alicia
authors.initials: A
authors.lastname: de Pablo
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Martín de Nicolás
mesh_terms: D001999:Bronchoscopy; D002951:Citrates / Q000008:administration & dosage; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006323:Heart Arrest; D006336:Heart Massage; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods; D010477:Perfusion / Q000379:methods; D055031:Primary Graft Dysfunction / Q000453:epidemiology / Q000517:prevention & control; D011859:Radiography; D012121:Respiration, Artificial; D012996:Solutions / Q000008:administration & dosage; D013030:Spain; D013997:Time Factors; D014019:Tissue Donors / Q000331:legislation & jurisprudence / Q000600:supply & distribution; D020858:Tissue and Organ Harvesting / Q000295:instrumentation / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000458:organization & administration* / Q000706:statistics & numerical data; D052096:Warm Ischemia
chemical_list: D002951:Citrates; C070005:Perfadex; D012996:Solutions