title: Bone marrow mononuclear cells and acute myocardial infarction.
abstract: Stem cell transplantation is emerging as a potential therapy to treat heart diseases. Promising results from early animal studies led to an explosion of small, non-controlled clinical trials that created even further excitement by showing that stem cell transplantation improved left ventricular systolic function and enhanced remodelling. However, the specific mechanisms by which these cells improve heart function remain largely unknown. A large variety of cell types have been considered to possess the regenerative ability needed to repair the damaged heart. One of the most studied cell types is the bone marrow-derived mononuclear cells and these form the focus of this review. This review article aims to provide an overview of their use in the setting of acute myocardial infarction, the challenges it faces and the future of stem cell therapy in heart disease.
authors.affiliation: Department of Cardiology, London Chest Hospital, Bonner Road, London E2 9JX, UK.
authors.forename: Samer
authors.initials: S
authors.lastname: Arnous
authors.forename: Abdul
authors.initials: A
authors.lastname: Mozid
authors.forename: John
authors.initials: J
authors.lastname: Martin
authors.forename: Anthony
authors.initials: A
authors.lastname: Mathur
mesh_terms: D000208:Acute Disease; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002986:Clinical Trials as Topic; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy*; D033581:Stem Cell Transplantation