title: A novel voltammetric sensor for amoxicillin based on nickel-curcumin complex modified carbon paste electrode.
abstract: The electrocatalytic oxidation of amoxicillin was investigated on a nickel-based (Ni(II)-curcumin) chemically modified electrode. This modified electrode was prepared by electropolymerization of complex (curcumin = 1,7-bis[4-hydroxyl-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) in alkaline solution. For the first time, the catalytic oxidation of amoxicillin was demonstrated by cyclic voltammetry, chronoamperometry, chronocoulometry and amperometry methods at the surface of this modified carbon paste electrode. The obtained results showed that NiOOH acts as an electrocatalyst for oxidation of amoxicillin. This electrocatalytic oxidation exhibited a good linear response for amoxicillin concentration over the range of 8 × 10⁻⁶-1×10⁻⁴ M with a detection limit of 5 × 10⁻⁶ M. Therefore, this electrocatalytic method was used as a simple, selective and rapid method able to determine amoxicillin in pharmaceutical preparations and biological media.
authors.affiliation: Electroanalytical Chemistry Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran. fer-o@umz.ac.ir
authors.forename: Reza
authors.initials: R
authors.lastname: Ojani
authors.forename: Jahan-Bakhsh
authors.initials: JB
authors.lastname: Raoof
authors.forename: Saeed
authors.initials: S
authors.lastname: Zamani
mesh_terms: D000658:Amoxicillin / Q000032:analysis*; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002244:Carbon / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D057230:Limit of Detection; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002244:Carbon; D009532:Nickel; D000658:Amoxicillin; D003474:Curcumin