title: Cortical mapping of the optically evoked responses in channelrhodopsin-2 mouse model.
abstract: Little is known about the information transfer properties of large-scale neural circuit in brain system. We applied optical deep brain stimulation to define the properties of information flow within a living brain assisted by channel rhodopsin-2 (ChR2) transgenic mice, of which neurons express the light-activated ion channel. We first characterized the responses of neuronal ensemble to the impinged light with respect to stimulation parameters by co-registering local field potentials with optical stimulation. Secondly, we applied recently developed polyimide based microarray for mouse electroencephalogram (EEG) to obtain the cortical responses with respect to deep brain stimulation. Particularly, the spatiotemporal cortical mapping with respect to deep brain stimulation of primary somatosensory cortex and hippocampus CA1 were presented in this article.
authors.affiliation: Brain Science Institute of the Korea Institute of Science and Technology, Seoul 136-791, South Korea. geud@kist.re.kr
authors.forename: Guk Bae
authors.initials: GB
authors.lastname: Kim
authors.forename: Jounhong Ryan
authors.initials: JR
authors.lastname: Cho
authors.forename: Hee-Sup
authors.initials: HS
authors.lastname: Shin
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000465:Algorithms; D000818:Animals; D000075402:Channelrhodopsins; D046690:Deep Brain Stimulation / Q000379:methods*; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods; D007477:Ions; D007834:Lasers; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D055100:Optical Fibers; D055095:Optics and Photonics; D012666:Semiconductors; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000473:pathology; D013997:Time Factors
chemical_list: D000075402:Channelrhodopsins; D007477:Ions