title: Acute and chronic animal models for the evaluation of anti-diabetic agents.
abstract: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential.
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Post Box: 38, Hisar-125001, India. pharm.vermasuresh@gmail.com
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: Rajeshwar
authors.initials: R
authors.lastname: Singh
authors.forename: Neeru
authors.initials: N
authors.lastname: Vasudeva
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000208:Acute Disease; D000818:Animals; D030801:Animals, Genetically Modified; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology; D002908:Chronic Disease; D048909:Diabetes Complications / Q000209:etiology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents