title: Dynamin, a membrane-remodelling GTPase.
abstract: Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. shawn.ferguson@yale.edu
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Ferguson
authors.forename: Pietro
authors.initials: P
authors.lastname: De Camilli
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D034281:Dynamins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004705:Endocytosis / Q000235:genetics / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D008560:Membrane Fluidity / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D007527:Isoenzymes; D020558:GTP Phosphohydrolases; D034281:Dynamins