title: Agranulocytosis induced by proton pump inhibitors.
abstract: We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors.
authors.affiliation: Department of Respiratory Medicine, University Hospital of Reims, Reims, France. sdury@chu-reims.fr
authors.forename: Sandra
authors.initials: S
authors.lastname: Dury
authors.forename: Julie
authors.initials: J
authors.lastname: Nardi
authors.forename: Claire
authors.initials: C
authors.lastname: Gozalo
authors.forename: François
authors.initials: F
authors.lastname: Lebargy
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Deslee
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19; D064098:Esomeprazole / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009154:Mutation; D009853:Omeprazole / Q000009:adverse effects; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D009853:Omeprazole; D064098:Esomeprazole