title: [Study on rat nasal absorption in situ of borneol based on single pass perfusion method].
abstract: OBJECTIVE
  To investigate the absorption characteristic of borneol.
  
  
  METHODS
  Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied.
  
  
  RESULTS
  Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact.
  
  
  CONCLUSIONS
  the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. songxiao1999@sohu.com
authors.forename: Xiao
authors.initials: X
authors.lastname: Song
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Huixian
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal / Q000379:methods; D000818:Animals; D001892:Camphanes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010477:Perfusion / Q000379:methods; D051381:Rats
chemical_list: D001892:Camphanes; D004365:Drugs, Chinese Herbal; C022871:isoborneol