title: Ternary resin-bound Dynamic Combinatorial Chemistry.
abstract: The ability to carry out simultaneous orthogonal exchange chemistries has opened new opportunities for increasing the numerical and structural diversity accessible to Dynamic Combinatorial Chemistry. We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity.
authors.affiliation: Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Gromova
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ciszewski
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Miller
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries