title: Associations of variants of CNR1 with obesity and obesity-related traits in Chinese women.
abstract: The aim of this study was to investigate associations of two candidate gene SNPs of the endocannabinoid receptor type 1 gene (CNR1) with overweight, obesity and obesity-related traits in Chinese retired women. The study subjects were a subsample of the Taizhou Retiree Women Cohort, consisting of 2812 retired women aged 50-64 years recruited from Taizhou, Jiangsu, China. Neither rs2023239 nor rs806381 polymorphism was significantly associated with body mass index-defined overweight and obesity or waist-to-hip-ratio-defined obesity. For obesity-related traits, rs2023239 was significantly associated with glutamate pyruvate transaminase (GPT) (median, 18.00 vs 17.00 for TT and TC genotypes, respectively, P=0.043). The rs806381 also showed significant association with triglyceride (TG) (mean±SD, 1.46±0.20 vs 1.53±0.20 for GA and GG+AA genotypes, respectively, P=0.013) under the dominant genetic model. In conclusion, the rs2023239 and rs806381 polymorphisms of CNR1 were not associated with increased overweight and obesity risk. But the rs2023239 polymorphism was significantly associated with GPT, and the rs806381 polymorphism was significantly associated with TG.
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
authors.forename: Maoqiang
authors.initials: M
authors.lastname: Zhuang
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.forename: Feifei
authors.initials: F
authors.lastname: Cao
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Xingdong
authors.initials: X
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Cheng
authors.forename: Nana
authors.initials: N
authors.lastname: Zhang
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Jin
mesh_terms: D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1; D014280:Triglycerides