title: A novel synergistic galactomannan-based unit dosage form for sustained release of acarbose.
abstract: In the current study, the potential of a novel combination of a galactomannan with acarbose (100 mg) was evaluated for attaining a desired hypoglycaemic effect over a prolonged period of time. Three major antidiabetic galactomannans viz., fenugreek gum, Boswellia gum, and locust bean gum were selected in order to achieve a synergistic effect in the treatment along with retardation in drug release. In vitro studies indicated that batches containing various proportions of fenugreek gum (AF40-60) were able to control drug release for a longer duration of approximately 10-12 h. In contrast, the matrices prepared using Boswellia and locust bean gum were able to sustain the release for relatively shorter durations. Drug release mainly followed first-order release kinetics owing to the highly soluble nature of the drug. In vivo study depicted a significant reduction (p < 0.001) in the postprandial blood glucose and triglyceride levels in the diabetic rats on treatment with formulation AF40. Thus, the developed system provides a better control of the postprandial glycaemic levels and it also obviates the need of conventional multiple dosing of acarbose. Furthermore, it also reduces the occurrence of side effects like diarrhea and loss of appetite.
authors.affiliation: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
authors.forename: Ruchita V
authors.initials: RV
authors.lastname: Kumar
authors.forename: Vivek Ranjan
authors.initials: VR
authors.lastname: Sinha
mesh_terms: D020909:Acarbose / Q000008:administration & dosage* / Q000378:metabolism*; D000818:Animals; D003692:Delayed-Action Preparations; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D004304:Dosage Forms; D004357:Drug Synergism; D005685:Galactans / Q000008:administration & dosage / Q000378:metabolism; D005690:Galactose / Q000031:analogs & derivatives; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008351:Mannans / Q000008:administration & dosage* / Q000378:metabolism*; D053149:Plant Gums / Q000008:administration & dosage / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D012116:Resins, Plant / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D012116:Resins, Plant; C012990:galactomannan; D020909:Acarbose; C017471:locust bean gum; D005690:Galactose