title: Computing by physical interaction in neurons.
abstract: The electrodynamics of action potentials represents the fundamental level where information is integrated and processed in neurons. The Hodgkin-Huxley model cannot explain the non-stereotyped spatial charge density dynamics that occur during action potential propagation. Revealed in experiments as spike directivity, the non-uniform charge density dynamics within neurons carry meaningful information and suggest that fragments of information regarding our memories are endogenously stored in structural patterns at a molecular level and are revealed only during spiking activity. The main conceptual idea is that under the influence of electric fields, efficient computation by interaction occurs between charge densities embedded within molecular structures and the transient developed flow of electrical charges. This process of computation underlying electrical interactions and molecular mechanisms at the subcellular level is dissimilar from spiking neuron models that are completely devoid of physical interactions. Computation by interaction describes a more powerful continuous model of computation than the one that consists of discrete steps as represented in Turing machines.
authors.affiliation: Department of Comparative Medicine, Stanford University, Palo Alto, CA 94305, USA. DorianAur@gmail.com
authors.forename: Dorian
authors.initials: D
authors.lastname: Aur
authors.forename: Mandar
authors.initials: M
authors.lastname: Jog
authors.forename: Roman R
authors.initials: RR
authors.lastname: Poznanski
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002450:Cell Communication; D003198:Computer Simulation; D008959:Models, Neurological; D009043:Motor Activity; D009474:Neurons / Q000502:physiology*; D017711:Nonlinear Dynamics