title: Tandem migration-carboalkoxylation of o-isocyanophenyl acetals leading to benzoxazoles.
abstract: An efficient approach to benzoxazoles via tandem migration-carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF(3)·OEt(2)/2,4,6-collidine combination is the best choice for cooperative transformation.
authors.affiliation: Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Kobe 658-8558, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okitsu
authors.forename: Kenta
authors.initials: K
authors.lastname: Nagase
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nishio
authors.forename: Akimori
authors.initials: A
authors.lastname: Wada
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000438:Alcohols / Q000737:chemistry*; D001583:Benzoxazoles / Q000138:chemical synthesis*; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000080:Acetals; D000438:Alcohols; D001583:Benzoxazoles; D003486:Cyanides; C059688:alkoxyl radical