title: An immunohistochemical study of interleukin-8 (IL-8) in breast cancer.
abstract: The use of prognostic markers for breast cancer is important for routine diagnosis and research. Interleukin-8 is a chemotactic cytokine produced by several cell types in response to inflammation, however, its expression, regulation and function are poorly understood. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. The present study investigated the correlation between interleukin-8 expression and breast cancer prognosis. Interleukin-8 expression was assessed in 72 women with mammary neoplasia by immunohistochemistry and the results were statistically correlated with clinical-pathological findings. There was an inverse correlation between interleukin-8 expression and metastasis (p=0.03) and/or local recurrence (p=0.02). In the patient group that received post-surgery chemotherapy and radiotherapy, a lower interleukin-8 expression was found in those women that showed local recurrence (p=0.01). Multivariate logistic regression showed estrogen receptor negativity, progesterone positivity and metastasis with increased risk of death (p<0.05). The data reflect the complexity of the role of interleukin-8 in tumor microenvironment and support its classification as a possible prognostic marker, although more studies are necessary for its inclusion in clinical practice.
authors.affiliation: Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, FAMERP, SP, Brazil. debora.zuccari@famerp.br
authors.forename: Debora Aparecida Pires de Campos
authors.initials: DA
authors.lastname: Zuccari
authors.forename: Camila
authors.initials: C
authors.lastname: Leonel
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Castro
authors.forename: Gabriela Bottaro
authors.initials: GB
authors.lastname: Gelaleti
authors.forename: Bruna Victorasso
authors.initials: BV
authors.lastname: Jardim
authors.forename: Marina Gobbe
authors.initials: MG
authors.lastname: Moscheta
authors.forename: Vitor Rafael
authors.initials: VR
authors.lastname: Regiani
authors.forename: Lívia Carvalho
authors.initials: LC
authors.lastname: Ferreira
authors.forename: Juliana Ramos
authors.initials: JR
authors.lastname: Lopes
authors.forename: Dalisio de Santi
authors.initials: Dde S
authors.lastname: Neto
authors.forename: José Luis
authors.initials: JL
authors.lastname: Esteves
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000032:analysis* / Q000096:biosynthesis; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D016209:Interleukin-8