title: Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects.
abstract: OBJECTIVE
  To evaluate the efficacy of two new mouthrinses in the reduction of xerostomía-associated symptomatology.
  
  
  BACKGROUND
  Xerostomia is a common chronic health condition that affects a great number of adults and significantly deteriorates quality of life, such that treatment is necessary.
  
  
  METHODS
  Sixty-seven adult subjects of both sexes presenting xerostomia of diverse origin were selected. Mouthrinses were tested using a double-blind, randomized, cross-over clinical trial with an intervining wash out period.
  
  
  RESULTS
  The 100% of subjects presented sensation of dry mouth, and 86% stated sensation of thick saliva. Burning tongue sensation, need to drink liquids to swallow and the sensation of swallowing difficulty were recorded in more than 50% of the patients. The most frequent pathologies in the sample were depression, arthritis, and arterial hypertension. Results of the clinical tests showed that mouthrinse 1 relieves sensation of dry mouth, need to drink liquids, and swallowing difficulty. In contrast, mouthrinse 2 relieves only latter two symptoms. Both rinses were more effective in relieving xerostomía-associated symptomatology in patients taking 3 or more medicines simultaneously.
  
  
  CONCLUSIONS
  Both mouthrinses were effective in relieving various xerostomia symptoms, could be distributed at a low cost, thereby improving the quality of life of population affected.
authors.affiliation: Oral Biology and Oral Biochemistry Laboratory, Department of Basic and Communitarian Sciences, Faculty of Dentistry, University of Chile, Chile, Santiago, Chile. imorales@uchile.cl
authors.forename: Irene
authors.initials: I
authors.lastname: Morales-Bozo
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Rojas
authors.forename: Ana
authors.initials: A
authors.lastname: Ortega-Pinto
authors.forename: Iris
authors.initials: I
authors.lastname: Espinoza
authors.forename: Lilian
authors.initials: L
authors.lastname: Soto
authors.forename: Anita
authors.initials: A
authors.lastname: Plaza
authors.forename: Carla
authors.initials: C
authors.lastname: Lozano
authors.forename: Blanca
authors.initials: B
authors.lastname: Urzúa
mesh_terms: D000328:Adult; D000504:Aloe; D001168:Arthritis / Q000188:drug therapy; D002054:Burning Mouth Syndrome / Q000517:prevention & control; D002594:Cetylpyridinium / Q000032:analysis; D019343:Citric Acid / Q000032:analysis; D018592:Cross-Over Studies; D003679:Deglutition / Q000187:drug effects; D003680:Deglutition Disorders / Q000517:prevention & control; D003863:Depression / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005421:Flavoring Agents / Q000032:analysis; D005990:Glycerol / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D031337:Mentha spicata; D008875:Middle Aged; D009067:Mouthwashes / Q000032:analysis / Q000627:therapeutic use*; D019946:Propylene Glycol / Q000032:analysis; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D012965:Sodium Chloride / Q000032:analysis; D012969:Sodium Fluoride / Q000032:analysis; D014059:Tongue / Q000187:drug effects; D016896:Treatment Outcome; D014987:Xerostomia / Q000517:prevention & control*; D014993:Xylitol / Q000032:analysis
chemical_list: D005421:Flavoring Agents; D009067:Mouthwashes; D019343:Citric Acid; D012965:Sodium Chloride; D019946:Propylene Glycol; D012969:Sodium Fluoride; D002594:Cetylpyridinium; D005990:Glycerol; D014993:Xylitol