title: New specific marker of cytochrome P450 1A2 activity.
abstract: Various methods were proposed for phenotyping of patients by activity of cytochrome P450 1A2, each has some advantages and disadvantages. However, no reference parameters were developed for measuring CYP1A2 activity that could be used as a unified standard for phenotyping of patients. We propose a mathematic model of caffeine metabolism allowing calculation of rate constants for the formation of its primary metabolites. First-order rate constant of paraxanthine formation was tested as a new specific marker of isoenzyme 1A2 in healthy volunteers.
authors.affiliation: Department of Clinical Pharmacology and Pharmacotherapy, Kazan' State Medical Academy, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Filimonova
authors.forename: L E
authors.initials: LE
authors.lastname: Ziganshina
authors.forename: A U
authors.initials: AU
authors.lastname: Ziganshin
authors.forename: A A
authors.initials: AA
authors.lastname: Chichirov
mesh_terms: D000465:Algorithms; D015415:Biomarkers; D002110:Caffeine / Q000378:metabolism*; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D006801:Humans; D008962:Models, Theoretical; D010641:Phenotype; D013806:Theophylline / Q000096:biosynthesis*
chemical_list: D015415:Biomarkers; D002110:Caffeine; D013806:Theophylline; D019388:Cytochrome P-450 CYP1A2; C021183:1,7-dimethylxanthine