title: Standardized diaper care regimen: a prospective, randomized pilot study on skin barrier function and epidermal IL-1α in newborns.
abstract: Adaptation of skin barrier function and interleukin-1α (IL-1α) content in diapered and nondiapered skin are poorly characterized in newborns receiving standard skin care. In a monocentric, prospective pilot study 44 healthy, full-term neonates were randomly assigned to skin care with baby wipes (n = 21) or water-moistened washcloth (n = 23) at each diaper change. Transepidermal water loss (TEWL), skin hydration, skin-pH, IL-1α, and epidermal desquamation were measured on days 2, 14, and 28 postpartum. Microbiological colonization was evaluated at baseline and on day 28. Significantly lower TEWL was found on the buttock in the group using baby wipes compared to water. IL-1α and skin hydration significantly increased and pH decreased independent of skin care regimen. IL-1α was significantly higher in diapered skin compared to nondiapered skin. Although skin care with wipes seems to stabilize TEWL better than using water, the skin condition and microbiological colonization were comparable using both cleansing procedures. Increase of epidermal IL-1α may reflect postnatal skin barrier maturation. These data suggest that neither of the two cleansing procedures harms skin barrier maturation within the first four weeks postpartum. Longer observations on larger populations could provide more insight into postnatal skin barrier maturation.
authors.affiliation: Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany. natalie.garcia-bartels@charite.de
authors.forename: Natalie
authors.initials: N
authors.lastname: Garcia Bartels
authors.forename: Lida
authors.initials: L
authors.lastname: Massoudy
authors.forename: Ramona
authors.initials: R
authors.lastname: Scheufele
authors.forename: Ekkehart
authors.initials: E
authors.lastname: Dietz
authors.forename: Hans
authors.initials: H
authors.lastname: Proquitté
authors.forename: Roland
authors.initials: R
authors.lastname: Wauer
authors.forename: Christiane
authors.initials: C
authors.lastname: Bertin
authors.forename: José
authors.initials: J
authors.lastname: Serrano
authors.forename: Ulrike
authors.initials: U
authors.lastname: Blume-Peytavi
mesh_terms: D002081:Buttocks; D041381:Diapers, Infant; D004817:Epidermis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007224:Infant Care / Q000379:methods*; D007231:Infant, Newborn; D053582:Interleukin-1alpha / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects; D017592:Skin Care / Q000379:methods*; D014870:Water Loss, Insensible
chemical_list: C508584:IL1A protein, human; D053582:Interleukin-1alpha