title: TET2, a tumor suppressor in hematological disorders.
abstract: The TET family of proteins has been described a few years ago. Only recently, their roles in DNA modification, through the oxidation of methyl-cytosine, and in normal and malignant development, through the description of TET2 as a tumor suppressor have been documented. The conjunction of these findings has prompted large efforts to understand the biology of these novel entities. Here, we summarize the recent results implicating TET2 in hematological malignancies suggesting that further studies are required to fully understand the role of DNA methylation alterations during transformation.
authors.affiliation: INSERM, U985, Villejuif, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mercher
authors.forename: Cyril
authors.initials: C
authors.lastname: Quivoron
authors.forename: Lucile
authors.initials: L
authors.lastname: Couronné
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: William
authors.initials: W
authors.lastname: Vainchenker
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics*; D049308:Dioxygenases; D004195:Disease Models, Animal; D057890:Epigenomics; D016147:Genes, Tumor Suppressor; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C541081:TET2 protein, human; C551914:Tet2 protein, mouse