title: Synergistic activity of coriander oil and conventional antibiotics against Acinetobacter baumannii.
abstract: In this study we investigated the existence of synergistic antibacterial effect between coriander (Coriandrum sativum L.) essential oil and six different antibacterial drugs (cefoperazone, chloramphenicol, ciprofloxacin, gentamicin, tetracycline and piperacillin). The antibacterial activity of coriander oil was assessed using microdilution susceptibility testing and synergistic interaction by checkerboard assays. The association of coriander essential oil with chloramphenicol, ciprofloxacin, gentamicin and tetracycline against Acinetobacter baumannii showed in vitro effectiveness, which is an indicator of a possible synergistic interaction against two reference strains of A. baumannii (LMG 1025 and LMG 1041) (FIC index from 0.047 to 0.375). However, when tested the involvement between coriander essential oil and piperacillin or cefoperazone, the isobolograms and FIC index showed an additive interaction. The in vitro interaction could improve the antimicrobial effectiveness of ciprofloxacin, gentamicin and tetracycline and may contribute to resensitize A. baumannii to the action of chloramphenicol.
authors.affiliation: CICS-Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6201-556 Covilhã, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Duarte
authors.forename: S
authors.initials: S
authors.lastname: Ferreira
authors.forename: F
authors.initials: F
authors.lastname: Silva
authors.forename: F C
authors.initials: FC
authors.lastname: Domingues
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D028526:Coriandrum / Q000737:chemistry*; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010938:Plant Oils; D002939:Ciprofloxacin; D002701:Chloramphenicol; D013752:Tetracycline; D010878:Piperacillin