title: [Effects of bushenhuoxue granules on sleep quality in Parkinson's patients].
abstract: OBJECTIVE
  To study the effects of Bushenhuoxue Granules on Parkinson's disease sleep scale (PDSS) score in Parkinson's patients.
  
  
  METHODS
  120 patients were enrolled and divided into two groups randomly,the control group were treated with placebo and treatment group with Bushenhuoxue Granules, both group based on Madopar treatment. Double-blinded clinical trial was adopted in treatment period. Follow-up period for 6 months, PDSS was adopted to measure sleep condition of PD patients at baseline time, after 3 months and after 9 months.
  
  
  RESULTS
  Bushenhuoxue Granules treatment group showed a higher efficacy than the placebo group in relieving the sleep disorders of Parkinson disease patients,both in treatment and follow-up period (P < 0.01). No adverse effects were found in this trial.
  
  
  CONCLUSIONS
  Bushenhuoxue Granules can markedly improve sleep disorders in Parkinson's patients. The effects are stable and obvious along with the process of treatment.
authors.affiliation: Department of Traditional Chinese Medicine, General Hospital of Chinese PLA, Beijing 100853, China. kittenlee1115@126.com
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001545:Benserazide / Q000009:adverse effects / Q000494:pharmacology; D004311:Double-Blind Method; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D017286:Polysomnography / Q000379:methods; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C005177:benserazide, levodopa drug combination; C527851:bushen huoxue; D007980:Levodopa; D001545:Benserazide