title: B-type natriuretic peptide in children with atrial or ventricular septal defect: a cardiac catheterization study.
abstract: In this study, we investigated the relationship between plasma B-type natriuretic peptide (BNP) levels and hemodynamics from cardiac catheterization in pediatric patients with atrial or ventricular septal defect. A total of 59 patients were studied including 80% of patients had Qp/Qs > 1.5 and 25% of patients had pulmonary hypertension. The mean BNP value and BNP z-score were 10.9 ± 11.2 pg/mL and -0.28 ± 1.7 (-2.85 to 3.29), respectively. There was a statistically significant linear correlation between BNP value and the size of defects (r = 0.303, p = 0.002) and a trend toward to positive correlation between BNP value and Qp/Qs ratio (r = 0.183, p = 0.166) among all patients. To identify patients with a Qp/Qs ratio >1.5, the sensitivity and specificity were 28%, 100% in all patients at a plasma BNP cut-off point of 15 pg/mL. We concluded that a BNP > 15 pg/mL would help identify patients who need further intervention.
authors.affiliation: Department of Paediatrics, Taichung Veterans General Hospital, Taichung, Taiwan. sljan@vghtc.gov.tw
authors.forename: Sheng-Ling
authors.initials: SL
authors.lastname: Jan
authors.forename: Yun-Ching
authors.initials: YC
authors.lastname: Fu
authors.forename: Betau
authors.initials: B
authors.lastname: Hwang
authors.forename: Shing-Jong
authors.initials: SJ
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000503:physiopathology; D006344:Heart Septal Defects, Atrial / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006345:Heart Septal Defects, Ventricular / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007223:Infant; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain