title: [Effects of honey to acyclovir in the rabbit eye transport kinetics].
abstract: OBJECTIVE
  Using pharmacokinetics to explore the mechanism of honey to enhance the efficacy of acyclovir (ACV) treatment of herpes simplex keratitis (HSK), providing the basis for combination of the prescription of two drugs and dosage regimen designed.
  
  
  METHODS
  Single dosages of 5% honey and 0% honey Meyasu eye ointment are injected into rabbit eyes. The aqueous humor of rabbit eye is measured at different times, specifically the content of ACV in aqueous humor by HPLC. Mathematical models are established, from which pharmacokinetic parameters are extracted and compared by mathematics and statistics methods.
  
  
  RESULTS
  Both the 5% and 0% honey Meyasu eye ointment in rabbit eyes are belong to a two-compartment model. The absorption half-life of the 5% Meyasu eye ointment in aqueous humor is as 2.30 times longer, the distribution half-life is 2.12 times longer, the peak concentration is 1.17 times longer, the peak time is 1.36 times longer, AUC is 1.41 times longer when compared to the 0% Meyasu eye ointment.
  
  
  CONCLUSIONS
  Honey can significantly increase the ACV concentration and bioavailability in the eye, extend the action time of ACV in target cells and increase the retention capacity of ACV in the target tissue; thereby improving treatment success.
authors.affiliation: Hunan University of Traditional Chinese Medicine and Drug Traditional Chinese Medicinal Pharmaceutics. chengguangyu58@126.com
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.forename: Shi
authors.initials: S
authors.lastname: Wang
authors.forename: Xianghui
authors.initials: X
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jiangli
authors.initials: J
authors.lastname: Xu
mesh_terms: D000212:Acyclovir / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005123:Eye / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006722:Honey / Q000032:analysis*; D006801:Humans; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D011817:Rabbits
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir