title: The contribution of bone to whole-organism physiology.
abstract: The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
authors.affiliation: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. gk2172@columbia.edu
authors.forename: Gérard
authors.initials: G
authors.lastname: Karsenty
authors.forename: Mathieu
authors.initials: M
authors.lastname: Ferron
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology; D001847:Bone Diseases / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology*; D004734:Energy Metabolism; D006801:Humans; D020738:Leptin / Q000378:metabolism; D009928:Organ Specificity; D015675:Osteocalcin / Q000378:metabolism; D010829:Physiological Phenomena
chemical_list: D020738:Leptin; D015675:Osteocalcin