title: Protecting group free, stereocontrolled synthesis of β-halo-enamides.
abstract: Enamides, dienamides, and enynamides are important building blocks in synthetic, biological, and medicinal chemistry as well as materials science. Despite the extensive breath of their potential utility in synthetic chemistry, there is a lack of simple, high-yielding methods to deliver them efficiently and as single isomers. In this paper, we present a novel, protecting group free, efficient, and stereoselective approach to the generation of β-halo-enamides. The methodology presented provides a robust synthetic platform from which E- or Z-enamides can be generated in good yields and with complete stereocontrol.
authors.affiliation: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Adele E
authors.initials: AE
authors.lastname: Pasqua
authors.forename: James J
authors.initials: JJ
authors.lastname: Crawford
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Long
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Marquez
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides