title: In vivo scintigraphic imaging of proteoglycans.
abstract: In this chapter, we present the methods developed in our lab for the scintigraphic imaging and direct quantitative evaluation of proteoglycan (PG) distribution in vivo. These methods relate to (1) the synthesis and radiolabeling of the NTP 15-5 with (99m)Tc, (2) preclinical scintigraphic imaging using laboratory animals, and (3) quantitative analysis of scintigraphic images.
authors.affiliation: INSERM, UMR 990, Clermont-Ferrand, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Miot-Noirault
authors.forename: Aurélien
authors.initials: A
authors.lastname: Vidal
authors.forename: Philippe
authors.initials: P
authors.lastname: Auzeloux
authors.forename: Caroline
authors.initials: C
authors.lastname: Peyrode
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Madelmont
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chezal
mesh_terms: D000818:Animals; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D051379:Mice; D011509:Proteoglycans / Q000032:analysis*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000737:chemistry
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; C407019:N-(triethylammonium)-3-propyl(15)ane-N5; D011509:Proteoglycans; D000644:Quaternary Ammonium Compounds; D013667:Technetium