title: Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers.
abstract: OBJECTIVE
  To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH).
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Tertiary referral center for reproductive medicine.
  
  
  METHODS
  Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF.
  
  
  METHODS
  Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays.
  
  
  METHODS
  Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve.
  
  
  RESULTS
  There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index.
  
  
  CONCLUSIONS
  No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort.
authors.affiliation: Department of Reproductive Medicine, St Mary's Hospital, Manchester, United Kingdom.
authors.forename: Lamiya
authors.initials: L
authors.lastname: Mohiyiddeen
authors.forename: William G
authors.initials: WG
authors.lastname: Newman
authors.forename: Helen
authors.initials: H
authors.lastname: McBurney
authors.forename: Betselot
authors.initials: B
authors.lastname: Mulugeta
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Roberts
authors.forename: Luciano G
authors.initials: LG
authors.lastname: Nardo
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004739:England; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016014:Linear Models; D015810:Linkage Disequilibrium; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D010062:Ovulation Induction; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011962:Receptors, FSH / Q000235:genetics* / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D011962:Receptors, FSH; D054304:Anti-Mullerian Hormone