title: [Recent advances in cord blood stem cell transplantation].
abstract: Cord blood stem cells are recognized as alternative donors for patients without HLA matched sibling donors in allogeneic stem cell transplantation, while limited number of stem cells are still associated with delayed or failed engraftment. To overcome this issue, clinical trials including reduced-intensity conditioning, double units transplantation, intrabone marrow injection as well as infusion of ex vivo expanded regulatory T cells have been performed. Chimerism analysis by multicolor flow cytometry is also valuable in monitoring the engraftment process. Future studies will test the potential application of cord blood stem cells to non-hematological disorders.
authors.affiliation: Division of Stem Cell Transplantation, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo.
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
mesh_terms: D036101:Cord Blood Stem Cell Transplantation / Q000379:methods / Q000639:trends*; D006801:Humans