title: Adapted timed up and go: a rapid clinical test to assess gait and cognition in multiple sclerosis.
abstract: OBJECTIVE
  To measure the Timed Up and Go (TUG), imagined TUG (iTUG), and the difference of time between these two tests (delta time) in 20 patients with relapsing-remitting multiple sclerosis (RRMS) and 20 healthy age-matched controls and to examine whether an association with cognitive functions, motor impairment, and behavioral changes can be determined.
  
  
  METHODS
  The mean ± SD of TUG, iTUG and delta time were used as outcomes. Spatiotemporal gait parameters were recorded by a 12-camera optoelectronic system during straight walking at usual self-selected speed. Cognitive functions were assessed by a standardized neuropsychological examination.
  
  
  RESULTS
  Patients performed the TUG slower than the controls (10.00 ± 1.70 s vs. 8.71 ± 1.04 s, p = 0.01, respectively). The TUG was correlated with gait parameters, cognitive functions, and behavior, whereas delta time was correlated only with cognitive functions.
  
  
  CONCLUSIONS
  TUG represents an interesting test to reveal subtle deficits in RRMS patients with low disability and is related to motor, cognitive, and behavioral functioning. Combining with the TUG, delta time could easily give additional information on specific cognitive functions in the assessment of patients with RRMS.
authors.affiliation: Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Geneva University, Geneva, Switzerland. gilles.allali@hcuge.ch
authors.forename: G
authors.initials: G
authors.lastname: Allali
authors.forename: M
authors.initials: M
authors.lastname: Laidet
authors.forename: F
authors.initials: F
authors.lastname: Assal
authors.forename: O
authors.initials: O
authors.lastname: Beauchet
authors.forename: M
authors.initials: M
authors.lastname: Chofflon
authors.forename: S
authors.initials: S
authors.lastname: Armand
authors.forename: P H
authors.initials: PH
authors.lastname: Lalive
mesh_terms: D000328:Adult; D003071:Cognition / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests