title: Expression of protein kinase C isoforms in cancerous breast tissue and adjacent normal breast tissue.
abstract: The role of protein kinase C (PKC) in the carcinogenesis of human breast tissue has been studied at the molecular level for more than two decades. In this study, we employed Western blotting to determine the presence of PKC isoforms in cancerous and normal breast tissues. The results indicate significant expression of a conventional PKC (PKCα) and two atypical PKCs (PKC ζ and λ/ι) in both breast tumors and adjacent normal breast tissue. For the α,ζ and λ/ι isoforms, the expression of individual isoforms was higher in the breast tumors than in the adjacent normal breast tissue. Although the correlation coefficient was low, significant linear correlation was found among the activities of the isoforms. The data suggest a potential new direction in cancer chemotherapy, namely the blockage of the signal transduction pathway of specific PKC isoforms.
authors.affiliation: Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan, Republic of China.
authors.forename: Yueh-Min
authors.initials: YM
authors.lastname: Lin
authors.forename: Cheng-Chuan
authors.initials: CC
authors.lastname: Su
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Su
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Hwang
authors.forename: Hsi-Hsien
authors.initials: HH
authors.lastname: Hsu
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
authors.forename: Yen-Chu
authors.initials: YC
authors.lastname: Wang
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Jer-Yuh
authors.initials: JY
authors.lastname: Liu
authors.forename: Li-Mien
authors.initials: LM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000201:enzymology*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007527:Isoenzymes; D011493:Protein Kinase C