title: Age at menarche, menstrual characteristics, and risk of preeclampsia.
abstract: We examined associations of age at menarche and menstrual characteristics with the risk of preeclampsia among participants (n = 3,365) of a pregnancy cohort study. Data were collected using in-person interviews and medical record abstraction. Logistic regression was used to estimate adjusted odds ratio (OR) and 95% confidence interval (95% CI). There was a significant inverse association between age at menarche and risk of preeclampsia (P value for trend < 0.05). Association of long cycle length (>36 days) with higher risk of preeclampsia was present only among women who had prepregnancy body mass index <25 kg/m(2) (interaction P value = 0.04). Early menarche is associated with higher risk of preeclampsia. Prepregnancy weight may modify associations of long menstrual cycles with risk of preeclampsia.
authors.affiliation: Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA.
authors.forename: Dejene F
authors.initials: DF
authors.lastname: Abetew
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Enquobahrie
authors.forename: Michal
authors.initials: M
authors.lastname: Dishi
authors.forename: Carole B
authors.initials: CB
authors.lastname: Rudra
authors.forename: Raymond S
authors.initials: RS
authors.lastname: Miller
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams