title: Interstrand cross-link of DNA by covalently linking a pair of abasic sites.
abstract: A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment.
authors.affiliation: Nippon Steel Kankyo Engineering Co. Ltd., 2-1-38 Shiohama, Kisarazu 292-0838, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kojima
authors.forename: Yu
authors.initials: Y
authors.lastname: Hirano
authors.forename: Toshie
authors.initials: T
authors.lastname: Takebayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Kowata
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Komatsu
mesh_terms: D000588:Amines / Q000737:chemistry; D001483:Base Sequence; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation
chemical_list: D000588:Amines; D003432:Cross-Linking Reagents; D004247:DNA