title: [The role of miR-223 in the acute rejection after kidney transplantation].
abstract: OBJECTIVE
  To explore the role of miR-223 in the acute rejection after kidney transplantation.
  
  
  METHODS
  33 patients who received kidney transplantation in our hospital within a year were collected and 12 of them appeared acute rejection within 1 month after surgery. In all the patients, the peripheral blood miR-223 level was collected and detected by blind arrangements. Furthermore, PBMCs from healthy volunteers were also collected and stimulated by PHA and then miR-223 level was measured.
  
  
  RESULTS
  In the peripheral blood cell, the miR-223 was increased 2 times after acute rejection, as well as 3. 76 times after PHA treatment.Furthermore, using miR-223 predicts AR had a specificity of 90% and sensitivity of 92%.
  
  
  CONCLUSIONS
  The miR-223 may have significant role in the acute rejection of kidney transplantation.
authors.affiliation: Department of Organ Transplantation, Zhujiang Hospital, Guangzhou, China. liuxy@fimmu.com
authors.forename: Xiao-you
authors.initials: XY
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; C525067:MIR223, human