title: Strong association between mRNA folding strength and protein abundance in S. cerevisiae.
abstract: One of the open questions in regulatory genomics is how the efficiency of gene translation is encoded in the coding sequence. Here we analyse recently generated measurements of folding energy in Saccharomyces cerevisiae, showing that genes with high protein abundance tend to have strong mRNA folding (mF; R=0.68). mF strength also strongly correlates with ribosomal density and mRNA levels, suggesting that this relation at least partially pertains to the efficiency of translation elongation, presumably by preventing aggregation of mRNA molecules.
authors.affiliation: School of Computer Science, and Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Zur
authors.forename: Tamir
authors.initials: T
authors.lastname: Tuller
mesh_terms: D019295:Computational Biology / Q000379:methods; D015966:Gene Expression Regulation, Fungal; D014176:Protein Biosynthesis; D059370:RNA Folding; D012333:RNA, Messenger / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins