title: [Sickle cell disease and invasive osteoarticular Salmonella infections].
abstract: Non-typhi Salmonella are responsible for severe invasive infections in children with sickle cell disease, with osteoarticular locations that can affect short- and long-term outcomes. We describe the cases of 2 children with sickle cell disease who presented paucisymptomatic Salmonella osteoarticular infections on returning from North Africa. Progression was favorable in both cases after appropriate systemic antibiotic therapy, although one Salmonella was multidrug-resistant. Invasive salmonellosis remains rare in France, but, because of its severity, it should be suspected in any patient with sickle cell disease presenting fever, especially in the context of recent trips in Africa countries. Early clinical diagnosis is essential to start appropriate empirical treatment without waiting for bacteriological results.
authors.affiliation: Service de pédiatrie générale, hôpital couple-enfant, CHU de Grenoble, avenue Maquis-du-Gresivaudan, 38700 La Tronche, France. AMillet@chu-grenoble.fr
authors.forename: A
authors.initials: A
authors.lastname: Millet
authors.forename: E
authors.initials: E
authors.lastname: Hullo
authors.forename: C
authors.initials: C
authors.lastname: Armari Alla
authors.forename: C
authors.initials: C
authors.lastname: Bost-Bru
authors.forename: C
authors.initials: C
authors.lastname: Durand
authors.forename: F
authors.initials: F
authors.lastname: Nugues
authors.forename: A
authors.initials: A
authors.lastname: Eid
authors.forename: D
authors.initials: D
authors.lastname: Plantaz
mesh_terms: D000462:Algeria / Q000208:ethnology; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001850:Bone Diseases, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D002675:Child, Preschool; D015299:Discitis / Q000175:diagnosis* / Q000188:drug therapy; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D005602:France; D006225:Hand; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007592:Joint Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008826:Microbial Sensitivity Tests; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy; D012480:Salmonella Infections / Q000175:diagnosis* / Q000188:drug therapy; D012486:Salmonella typhimurium; D014195:Travel; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents