title: [Study of expression and significance of DSCR1 gene in laryngopharynx cancer and peri-cancerous tissues].
abstract: OBJECTIVE
  To study the expressions of DSCR1 gene in laryngopharynx cancer and peri-cancerous tissues, to understand the relationship between its expression and tumor clinical features, to discussed the influence of DSCR1 gene on the biological behaviours of laryngopharynx squamous cell carcinoma.
  
  
  METHODS
  Immunohistochemical p-V9000 method,used rabbit DSCR1 antibody DCT3, detected the expressions of DSCR1 gene protein in laryngopharynx cancer and peri-cancerous tissues, between them and clinical data were statistically analyzed.
  
  
  RESULTS
  Positive rates of DSCR1 gene expression in the tumor tissues was 94.9%, normal tissues was 35.9%, there was a statistically significant (t = 23.69, P < 0.01); There was significant difference of DSCR1 gene expressions in different pathological degree and TNM staging (P < 0.05). There was no significant difference in different age, gender, site, growth mode, lymph node metastasis and smoking history.
  
  
  CONCLUSIONS
  DSCR1 gene has an important role in the occurrence and development process of laryngopharynx squamous cell carcinoma, and can influence the biological behavior of tumors.
authors.affiliation: Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Ji' nan, 250012, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lü
authors.forename: Xinliang
authors.initials: X
authors.lastname: Pan
authors.forename: Ju
authors.initials: J
authors.lastname: Gao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins; D005260:Female; D015870:Gene Expression; D006801:Humans; D007013:Hypopharynx / Q000473:pathology*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics*; D009367:Neoplasm Staging
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; C108612:RCAN1 protein, human