title: A new prenylated flavanone from Derris trifoliata Lour.
abstract: A new flavanone, 4',5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy-6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol was isolated for the first time from the genus Derris. Their structures were characterized on the basis of spectral data. Eight of the isolated compounds were found to be significantly toxic to brine shrimp (LC(50) range 0.06-9.95 μg/mL). The new compound showed weak toxicity (LC(50) = 211.31 μg/mL).
authors.affiliation: Department of Pharmacy, Medical College, Hunan Normal University, Changsha 410006, China. dangdangli@tom.com
authors.forename: Cheng
authors.initials: C
authors.lastname: Jiang
authors.forename: Shengzi
authors.initials: S
authors.lastname: Liu
authors.forename: Weihong
authors.initials: W
authors.lastname: He
authors.forename: Xiongming
authors.initials: X
authors.lastname: Luo
authors.forename: Si
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Xiao
authors.forename: Ximin
authors.initials: X
authors.lastname: Qiu
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D029866:Derris / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
chemical_list: C571653:4',5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)-flavanone; D003603:Cytotoxins; D044950:Flavanones; D010936:Plant Extracts