title: Sesquiterpenes inhibiting NO production from Celastrus orbiculatus.
abstract: Two new (1 and 2) and one known (3) β-dihydroagarofuran sesquiterpenes were isolated from the fruits of Celastrus orbicultus Thunb. Their structures were elucidated as 1β,13-diacetoxy-8β,9β-dibenzoyloxy-β-dihydroagarofuran (1), 1β,13-diacetoxy-8α-hydroxy-9β-benzoyloxy-β-dihydroagarofuran (2), and 1β,6α,13-triacetoxy-9α-benzoyloxy-β-dihydroagarofuran (3), on the basis of spectroscopic data analyses. All the compounds exhibited inhibitory effects on LPS-induced nitric oxide production in murine microglial BV-2 cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Da-qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Song
authors.forename: Zhanping
authors.initials: Z
authors.lastname: Sun
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D031247:Celastrus / Q000737:chemistry* / Q000378:metabolism*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide