title: Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications.
abstract: Adult Attention Deficit Hyperactivity Disorder (A-ADHD) is one of the psychiatric disorders which awareness is growing. The exact causes of A-ADHD are still unknown. In addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in its etiology. In our study, we aimed to evaluate the oxidative status of A-ADHD patients and investigate whether oxidative metabolites can be used as diagnostic tools or not in A-ADHD. Blood samples were taken from enrolled 50 A-ADHD patients and 31 controls in appropriate way and Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups and ROC curve was drawn in order to evaluate diagnostic performances. Patients' TAS, TOS and OSI were significantly higher than controls. There was not a significant difference between comorbid cases and only A-ADHD patients in terms of measured values. A-ADHD can be predicted for TOS over 9.8575 μmol H(2)O(2) Eqv./L level with 86% positive predictive value and %100 negative predictive value. In A-ADHD, oxidative balance is impaired. High antioxidant levels may be compensatory against the oxidant increase. Oxidative parameters may be used in A-ADHD diagnosis.
authors.affiliation: Harran University, Faculty of Medicine, Psychiatry Dept., Yenisehir Kampus, 63300 Sanliurfa, Turkey. drselek@yahoo.com
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulut
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Ocak
authors.forename: Aysun
authors.initials: A
authors.lastname: Kalenderoğlu
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savaş
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D013053:Spectrophotometry; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D006861:Hydrogen Peroxide