title: Ganoderma atrum polysaccharide improves age-related oxidative stress and immune impairment in mice.
abstract: The aim of the present study was to investigate whether oxidative stress and immune dysfunction could be attenuated by  Ganoderma atrum  polysaccharide (PSG-1) in d-galactose (d-gal)-induced aging mice, and provide evidence for its effects. The results showed that PSG-1 significantly decreased lipid peroxidation in liver, brain, and spleen, but concomitantly increased the activities of superoxide dismutase, catalase, and glutathione peroxidase compared with the d-gal group. Elevation of glutathione contents and attenuation of glutathione disulfide contents were also found in PSG-1-treated animals. Furthermore, the results showed that PSG-1 treatment increased basal lymphocyte proliferation as well as T cell and B cell proliferation and enhanced interleukin-2 production. Taken together, the results suggested that PSG-1 had potential as a novel agent to promote health and improve aging-associated pathologies, at least in part, via modification of the redox system and improvement of immune function.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Li
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Peng
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Jing-En
authors.initials: JE
authors.lastname: Li
authors.forename: Wan-Rui
authors.initials: WR
authors.lastname: Song
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
mesh_terms: D000375:Aging / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005690:Galactose; D032902:Ganoderma / Q000737:chemistry*; D007154:Immune System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D007376:Interleukin-2 / Q000096:biosynthesis; D015227:Lipid Peroxidation / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D011134:Polysaccharides / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D007376:Interleukin-2; D011134:Polysaccharides; D005690:Galactose