title: Neuroendocrine and proliferative potential of human intestinal cells during aging.
abstract: A population of neuroendocrine cells secreting chromogranin A was verified in the intestine of subjects aged over 60 years. The count of intestinal cells expressing chromogranin A and Ki-67 proliferation protein increases with aging. More intensive expression of chromogranin A and Ki-67 protein in senile age and in long-livers is presumably a compensatory mechanism aimed at the gastrointestinal function maintenance during its age-associated involution.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, North Western Division of the Russian Academy of Medical Sciences, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Trofimov
authors.forename: N N
authors.initials: NN
authors.lastname: Sevostianova
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: A N
authors.initials: AN
authors.lastname: Kolmakov
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D049109:Cell Proliferation; D053379:Chromogranin A / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology; D019394:Ki-67 Antigen / Q000378:metabolism*; D008875:Middle Aged; D055099:Neuroendocrine Cells / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000378:metabolism
chemical_list: D053379:Chromogranin A; D019394:Ki-67 Antigen