title: Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.
abstract: Two new eudesmane-type sesquiterpene glucosides, 9β-O-(E-p-hydroxycinnamoyl)-1β,6β-dihydroxy-trans-eudesm-3-en-6-O-β-D-glucopyranoside (1) and 9α-O-(E-p-hydroxycinnamoyl)-1α,6α-11-trihydroxy-trans-eudesm-3-en-6-O-β-D-glucopyranoside (2), were isolated by the activity-guidedfractionation of an EtOAc-soluble fraction from the aerial parts of Aster koraiensis. A new dihydrobenzofuran glucoside, (2R,3S)-6-acetyl-2-[1-O-(β-D-glucopyranosyl)-2-propenyl]-5-hydroxy-3-methoxy-2,3-dihydrobenzofuran (3), was also isolated, in addition to 15 known compounds. The structures of 1-3 were determined by spectroscopic data interpretation. All of the isolates were evaluated for in vitro inhibitory activity against the formation of advanced glycation end-products and rat lens aldose reductase.
authors.affiliation: Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research,  Korea Institute of Oriental Medicine  (KIOM), Daejeon 305-811, Republic of Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Byong Won
authors.initials: BW
authors.lastname: Lee
authors.forename: Joo-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D031173:Aster Plant / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D051381:Rats; D056910:Republic of Korea; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: C571474:9alpha-O-(E-p-hydroxycinnamoyl)-1alpha,6alpha-11-trihydroxy-trans-eudesm-3-en-6-O-beta-D-glucopyranoside; C571473:9beta-O-(E-p-hydroxycinnamoyl)-1beta,6beta-dihydroxy-trans-eudesm-3-en-6-O-beta-D-glucopyranoside; D005960:Glucosides; D017127:Glycation End Products, Advanced; D012717:Sesquiterpenes; D000449:Aldehyde Reductase