title: Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection.
abstract: The study of interactions between organic biomolecules and semiconducting surfaces is an important consideration for the design and fabrication of field-effect-transistor (FET) biosensor. This paper demonstrates DNA detection by employing a double-gate field effect transistor (DGFET). In addition, an investigation of sensitivity and signal to noise ratio (SNR) is carried out for different values of analyte concentration, buffer ion concentration, pH, reaction constant, etc. Sensitivity, which is indicated by the change of drain current, increases non-linearly after a specific value (~ 1 nM) of analyte concentration and decreases non-linearly with buffer ion concentration. However, sensitivity is linearly related to the fluidic gate voltage. The drain current has a significant effect on the positive surface group (-NH(2)) compared to the negative counterpart (-OH). Furthermore, the sensor has the same response at a particular value of pH (5.76) irrespective of the density of surface group, although it decreases with pH value. The signal to noise ratio is improved with higher analyte concentrations and receptor densities.
authors.affiliation: School of Engineering, Deakin University, Geelong, Victoria 3217, Australia. msi@deakin.edu.au
authors.forename: Md Saiful
authors.initials: MS
authors.lastname: Islam
authors.forename: Abbas Z
authors.initials: AZ
authors.lastname: Kouzani
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D007700:Kinetics; D008962:Models, Theoretical; D009693:Nucleic Acid Hybridization
chemical_list: D004247:DNA