title: A new aristolactam-type alkaloid from the roots of Aristolochia fangchi.
abstract: Phytochemical investigation of 85% ethanol extracts from the roots of Aristolochia fangchi yielded a new aristolactam derivative named 6-methoxyl aristolactam I N-β-glucoside (1), together with four known compounds, aristolactam IVa (2), aristolactam I-β-D-glucoside (3), aristolactam I (4), and aristolactam-N-β-D-glucoside (5). Their structures were elucidated by spectral analysis. The cytotoxicity of the isolated compounds was also determined.
authors.affiliation: Department of Traditional Chinese Medicine, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. lujunzhangpla@gmail.com
authors.forename: Jun-Zhang
authors.initials: JZ
authors.lastname: Lu
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D030022:Aristolochia / Q000737:chemistry*; D034341:Aristolochic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013552:Swine
chemical_list: C571133:6-methoxyl aristolactam I N-beta-glucoside; D000470:Alkaloids; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D007769:Lactams; C121135:aristolactam I