title: Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats.
abstract: The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.
authors.affiliation: Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo - São Paulo, SP, Brazil. nicastro@usp.br
authors.forename: Humberto
authors.initials: H
authors.lastname: Nicastro
authors.forename: Claudia R
authors.initials: CR
authors.lastname: da Luz
authors.forename: Daniela F S
authors.initials: DF
authors.lastname: Chaves
authors.forename: William
authors.initials: W
authors.lastname: das Neves
authors.forename: Kerolyn S
authors.initials: KS
authors.lastname: Valente
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Lancha
mesh_terms: D000818:Animals; D003907:Dexamethasone; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007930:Leucine / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D055070:Resistance Training
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D003907:Dexamethasone; D007930:Leucine