title: Iodinated glycidyl methacrylate copolymer as a radiopaque material for biomedical applications.
abstract: Polymeric biomaterial was synthesized by copolymerizing 50:50 mol% of monomers, glycidyl methacrylate and methyl methacrylate. Iodine atoms were then grafted to the epoxide groups of glycidyl methacrylate units, rendering the copolymer radiopaque. The percentage weight of iodine in the present copolymer was found to be as high as 23%. The iodinated copolymer showed higher glass transition temperature and thermal stability in comparison with unmodified polymer. Radiographic analysis showed that the copolymer possessed excellent radiopacity. The iodinated copolymer was cytocompatible to L929 mouse fibroblast cells. The in vivo toxicological evaluation by intracutaneous reactivity test of the copolymer extracts has revealed that the material was nontoxic. Subcutaneous implantation of iodinated copolymer in rats has shown that the material was well tolerated. Upon explantation and histological examination, no hemorrhage, infection or necrosis was observed. The samples were found to be surrounded by a vascularized capsule consisting of connective tissue cells. The results indicate that the iodinated copolymer is biocompatible and may have suitable applications as implantable materials.
authors.affiliation: Polymer Science Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Dawlee
authors.forename: M
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D020007:Implants, Experimental; D007455:Iodine / Q000737:chemistry; D008422:Materials Testing; D008768:Methylmethacrylates / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D008768:Methylmethacrylates; C531903:poly(glycidyl methacrylate)-co-(methyl methacrylate); D007455:Iodine