title: Hemodialysis for methyl alcohol poisoning: a single-center experience.
abstract: Methanol is a cheap and potent adulterant of illicit liquors. Hemodialysis (HD) is the best method to rapidly remove both toxic acid metabolites and parent alcohols, and it plays a fundamental role in treating severely poisoned patients. This retrospective study was carried out on 91 patients with detectable serum methanol levels who underwent HD. Because toxic alcohol levels were not immediately available, the initial diagnosis and treatment was based on clinical history with evidence of toxic alcohol intake, presence of high anion metabolic acidosis and/or end organ damage. Patients received bicarbonate, ethanol, according to clinical features and blood gases. Patients underwent HD in the setting of known methanol ingestion with high anion gap metabolic acidosis, or evidence of end-organ damage, regardless of methanol level. HD prescription included large surface area dialyzer (≥ 1.5 m²), blood flow rate of 250-350 mL/min and dialysate flow rate of 500 mL/min for 4-6 h. Between 9 and 11 July 2009, 91 males with mean age 40 ± 8.5 years underwent HD, and 13 patients required a second HD session. Patients consumed 100-500 mL illicit liquors, and symptoms appeared six and 60 h later. Clinical features were gastro-intestinal symptoms (83.5%), visual disturbances (60.4%), central nervous system symptoms (59.3%) and dyspnea (43.9%). Before HD, mean pH was 7.11 ± 0.04 (range 6.70- 7.33) and mean bicarbonate levels were 8.5 ± 4.9 mmol/L (range 2-18). Three patients died due to methanol intoxication. Mortality was associated with severe metabolic acidosis (pH ≤ 6.90), ventilator requirement and coma/seizure on admission (P < 0.001). Timely HD, bicarbonate, ethanol and supportive therapy can be life-saving in methanol intoxication.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Ahmedabad, India. drvivekkute@rediffmail.com
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Kute
authors.forename: Suraj M
authors.initials: SM
authors.lastname: Godara
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Shah
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Gumber
authors.forename: Kamal R
authors.initials: KR
authors.lastname: Goplani
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: Bipin C
authors.initials: BC
authors.lastname: Munjappa
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Patel
authors.forename: Hargovind L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D000138:Acidosis / Q000139:chemically induced / Q000628:therapy; D000328:Adult; D000434:Alcoholic Beverages / Q000506:poisoning*; D001639:Bicarbonates / Q000008:administration & dosage; D016009:Chi-Square Distribution; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D003131:Combined Modality Therapy; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007194:India; D008297:Male; D000432:Methanol / Q000097:blood / Q000506:poisoning*; D008875:Middle Aged; D011041:Poisoning / Q000209:etiology / Q000401:mortality / Q000628:therapy; D006435:Renal Dialysis; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012640:Seizures / Q000139:chemically induced / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001639:Bicarbonates; D000431:Ethanol; D000432:Methanol