title: Epileptic seizure detection with the local field potential of anterior thalamic of rats aiming at real time application.
abstract: Treating epilepsy with deep brain stimulation (DBS) is attracting more and more attention these years, especially the close loop method that gives stimuli when needed so that the implanted device will work longer. People have tried to detect seizure with electrocorticogram (ECoG), but the extra implants put more risks to it. We plan to detect seizure with local field potential (LFP) that recorded with depth electrodes of traditional DBS. To prove the validation of this method, we recorded local field potential (LFP) of anterior thalamic (ANT) of rats who have been induced to acute temporal lobe epilepsy (TLE) by kainic acid injected in hippocampus, and succeeded in detecting electrographic onset (EO) in these data. A variation of generic Osorio-Frei algorithm (GOFA) was used as the detection method with some adjustments which mainly focus on increasing calculation speed and decreasing number of total calculations to meet the future need of transplanting to battery powered embedded medical device.
authors.affiliation: School of Aerospace Tsinghua University, Beijing 100084, China. liuxiaoyin08@gmail.com
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Liu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Hao
authors.forename: Linchang
authors.initials: L
authors.lastname: Yang
authors.forename: Luming
authors.initials: L
authors.lastname: Li
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhang
authors.forename: Anchao
authors.initials: A
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000465:Algorithms; D000818:Animals; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods; D004195:Disease Models, Animal; D011211:Electric Power Supplies; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000628:therapy*; D004864:Equipment and Supplies; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D007608:Kainic Acid / Q000737:chemistry; D008297:Male; D009474:Neurons / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000175:diagnosis*; D013788:Thalamus / Q000473:pathology*
chemical_list: D007608:Kainic Acid