title: [Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes].
abstract: OBJECTIVE
  To study the characteristics of intestinal absorption of icariin and epimedin C of Xianlinggubao capsules, and compare the absorption of Xianlinggubao capsules prepared by different processes.
  
  
  METHODS
  Non everted gut sac method was applied to investigate the influence of absorption sites and concentration on icariin and epimedin C, which were determined by HPLC.
  
  
  RESULTS
  The absorption rate constants of epimedin C in duodenum were absolutely more than that in jejunum and ileum (P < 0.05). The absorption rate constants of icariin in jejunum were absolutely less than that in duodenum and ileum (P < 0.05). The absorption rate constants of epimedin C and icariin kept at the same level when the concentrations of drug solution were at high, middle and low level. The Ka of epimedin C at three levels were 0.040, 0.058, 0.061 h(-1) , respectively, and the Ka of icariin at three levels were 0.002, 0.007, 0.003 h(-1), respectively.
  
  
  CONCLUSIONS
  Intestinal absorption of icariin and epimedin C is not effected by concentrations. The absorption rate constants of icariin and epimedin C in new Xianlinggubao capsules are higher.
authors.affiliation: Department of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. wuhuichao1011@126.com
authors.forename: Huichao
authors.initials: H
authors.lastname: Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000493:pharmacokinetics*; D034181:Epimedium / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C106054:epimedin C