title: A new chromone from Angelica polymorpha with cytotoxic activity.
abstract: A new chromone polymorchromone B was isolated and characterized from the roots of Angelica polymorpha Maxim, a commonly used traditional Chinese medicine. On the basis of spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectral data, and hydrolysis followed by chromatographic analysis, the structure of the new chromone was elucidated as 5-hydroxy-2-[(angeloyloxy)methyl]-2'-(dimethyl)-3'-(2S,3S-epoxy-2-methylbutanoate)-dihydropyran [3',2':6,7]chromone. Moreover, it was found that polymorchromone B showed remarkable cytotoxic activity against A-549 cell lines.
authors.affiliation: Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan 250062, China. yangsj118@tom.com
authors.forename: Shang-Jun
authors.initials: SJ
authors.lastname: Yang
authors.forename: Qing-Qiang
authors.initials: QQ
authors.lastname: Yao
authors.forename: Ye-Na
authors.initials: YN
authors.lastname: Li
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Chen
authors.forename: Shu-Xiang
authors.initials: SX
authors.lastname: Cui
authors.forename: Shao-Yan
authors.initials: SY
authors.lastname: Bai
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Wang
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; C570615:polymorchromone B