title: Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells.
abstract: The ability of microglial cells to phagocytose bacteria after stimulation with the endocannabinoid palmitoylethanolamide (PEA) was studied in vitro. PEA increased the phagocytosis of unencapsulated Streptococcus pneumoniae R6 and encapsulated Escherichia coli K1 by murine microglial cells significantly after 30 min of microglial stimulation. This suggested that stimulation of microglial cells by PEA can increase the resistance of the brain against CNS infections.
authors.affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Redlich
authors.forename: Sandra
authors.initials: S
authors.lastname: Ribes
authors.forename: Sandra
authors.initials: S
authors.lastname: Schütze
authors.forename: Dirk
authors.initials: D
authors.lastname: Czesnik
authors.forename: Roland
authors.initials: R
authors.lastname: Nau
mesh_terms: D000577:Amides; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D063388:Endocannabinoids; D004926:Escherichia coli / Q000276:immunology*; D004983:Ethanolamines; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000187:drug effects* / Q000276:immunology; D010169:Palmitic Acids / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D063388:Endocannabinoids; D004983:Ethanolamines; D010169:Palmitic Acids; C005958:palmidrol