title: Exploring the role of prolactin in psoriasis.
abstract: Prolactin (PRL) is well recognised for its role(s) in mammary gland development and function. Moreover, its role in skin biology, including the potent regulation of human hair growth, is becoming clearer. Less widely appreciated, however, is the potential role of PRL in the pathobiology of psoriasis. While the relationship between PRL and psoriasis remains enigmatic, several recent publications on the PRL-psoriasis connection have demonstrated a reawakening of interest in this conundrum. We take the occasion of these reports to underscore the importance of dissecting the role(s) of PRL in the aetiopathology of psoriasis, not least since this may help to identify novel hormonal treatment strategies in its management.
authors.affiliation: Dermatology Centre, Salford Royal NHS Foundation Trust, School of Translational Medicine, Manchester Academic Health Science Centre, The University of Manchester, UK. ewan.langan@manchester.ac.uk
authors.forename: Ewan A
authors.initials: EA
authors.lastname: Langan
authors.forename: Christopher E M
authors.initials: CE
authors.lastname: Griffiths
authors.forename: Ralf
authors.initials: R
authors.lastname: Paus
mesh_terms: D000818:Animals; D048708:Cell Growth Processes; D005786:Gene Expression Regulation; D006197:Hair / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D056747:Immunomodulation; D007633:Keratins / Q000235:genetics / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism* / Q000503:physiopathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D013315:Stress, Psychological
chemical_list: D007633:Keratins; D011388:Prolactin