title: Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer.
abstract: OBJECTIVE
  Prolidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.
  
  
  METHODS
  Thirty-five patients with bladder cancer and 32 controls were enrolled. Serum TAS, MDA, prolidase activity and NO levels were determined.
  
  
  RESULTS
  Serum prolidase activity, NO levels and MDA levels were significantly higher in bladder cancer than controls (all, P < 0.05), while TAS levels were significantly lower (P < 0.05).
  
  
  CONCLUSIONS
  Our results show that increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer.
authors.affiliation: Department of Urology, Yuzuncu Yil University, Van, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Gecit
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gunes
authors.forename: Necip
authors.initials: N
authors.lastname: Pirincci
authors.forename: Ramazan
authors.initials: R
authors.lastname: Esen
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Kadir
authors.initials: K
authors.lastname: Ceylan
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D002277:Carcinoma / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004150:Dipeptidases / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D004150:Dipeptidases; C022449:proline dipeptidase