title: Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog.
abstract: A 6-year-old female Labrador retriever presented with a mass in the right mammary gland, and swollen right inguinal and axillary lymph nodes. Fine needle aspiration biopsy suggested a malignant lipid-producing tumor, such as liposarcoma. Histopathologically, the neoplasms were solid, lobulated nests of atypical epithelial cells with a large amount of extracellular deposits of amyloid in both mammary gland and lymph nodes. The proliferating cells contained large cytoplasmic vacuoles, positive for oil red-O. These cells were immunopositive for cytokeratin (AE1/AE3) and β-casein and negative for SMA. The amyloid deposits were immunopositive for β-casein. These findings suggested that the proliferating cells secreted β-casein forming amyloid deposits. This is the first report of mammary lipid-rich carcinoma with extensive amyloid deposition derived from β-casein.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors.forename: Meina
authors.initials: M
authors.lastname: Tei
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.forename: Hiromi
authors.initials: H
authors.lastname: Harada
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nishimura
authors.forename: Manabu
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D001391:Azo Compounds; D044963:Biopsy, Fine-Needle / Q000662:veterinary; D002364:Caseins / Q000378:metabolism*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006652:Histological Techniques / Q000379:methods / Q000662:veterinary; D007633:Keratins; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D058225:Plaque, Amyloid / Q000473:pathology*
chemical_list: D001391:Azo Compounds; D002364:Caseins; D007633:Keratins; C011049:oil red O