title: [Acute myeloid leukemia with t(16;21)(q24;q22) in a child].
abstract: The t(16;21)(q24;q22), a rare chromosomal translocation observed mostly in therapy-related acute myelogenous leukemia (AML), produces a RUNX1-CBFA2T3 fusion gene. Here we report a de novo AML case of 1-year-old girl with t(16;21)(q24;q22). In this case, we demonstrated the RUNX1-CBFA2T3 fusion gene and established quantitative RT-PCR for detecting minimal residual disease.
authors.affiliation: Department of Clinical Laboratory, Kobe University Hospital.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakamachi
authors.forename: Chinami
authors.initials: C
authors.lastname: Oyabu
authors.forename: Tomoe
authors.initials: T
authors.lastname: Kikuma
authors.forename: Daiichiro
authors.initials: D
authors.lastname: Hasegawa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishiyama
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kosaka
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
mesh_terms: D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic