title: Biologically active bergenin derivatives from Bergenia stracheyi.
abstract: New bergenin derivatives, bergecins A and B (1 and 2, resp.), have been isolated from the AcOEt-soluble fraction of Bergenia stracheyi, along with bergenin (3), and their structures were elucidated on the basis of (1) H- and (13) C-NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme lipoxygenase, while 1 was moderately active. On the other hand, both compounds exhibited significant antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay.
authors.affiliation: Department of Applied Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Siddiq
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.forename: Mehreen
authors.initials: M
authors.lastname: Lateef
authors.forename: Saira
authors.initials: S
authors.lastname: Hameed
authors.forename: Sher Wali
authors.initials: SW
authors.lastname: Khan
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001578:Benzopyrans; D004791:Enzyme Inhibitors; C571972:bergecin A; C571973:bergecin B; C006741:bergenin