title: [The structure of cellular vaults, their role in the normal cell and in the multidrug resistance of cancer].
abstract: The cellular vaults have been described for the first time in 1986 as ribonucleoprotein complexes composed of three proteins, MVP, TEP1 and vPARP and several vRNA strains. Biochemical and structural studies revealed their ubiquitous existence in the cytoplasm of many eukaryotic cells and their barrel-like structure indicating their engagement in the intracellular transport. Furthermore, the high homology between MVP and LRP which was already known to be involved in multidrug resistance mechanism opened a discussion about the role of vaults in both normal and cancer cells. The histopathology research demonstrated an increased amount of MVP/LRP proteins in the cancer as well as showed translocation possibility between cytoplasm and nuclear envelope, which can be of crucial point in the prevention of nucleus against anticancer drugs.
authors.affiliation: Katedra i Zakład Histologii i Embriologii, Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu, Poznań. witold.szaflarski@gmail.com
authors.forename: Witold
authors.initials: W
authors.lastname: Szaflarski
authors.forename: Michał
authors.initials: M
authors.lastname: Nowicki
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
mesh_terms: D003593:Cytoplasm / Q000473:pathology; D018432:Drug Resistance, Multiple / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D020394:Vault Ribonucleoprotein Particles / Q000737:chemistry* / Q000378:metabolism*; D000099187:Major Vault Protein
chemical_list: D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein