title: Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease.
abstract: Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.
authors.affiliation: Department of Neurology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan.
authors.forename: Han-Lin
authors.initials: HL
authors.lastname: Chiang
authors.forename: Guey-Jen
authors.initials: GJ
authors.lastname: Lee-Chen
authors.forename: Chiung Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Chei-Mei
authors.initials: CM
authors.lastname: Lee
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Liao
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059805:HLA-DR alpha-Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012016:Reference Values; D013624:Taiwan; D044465:White People; D055815:Young Adult
chemical_list: D059805:HLA-DR alpha-Chains