title: Synthesis and antimicrobial activity of 2,3-bis(bromomethyl)quinoxaline derivatives.
abstract: We synthesized 12 derivatives of 2,3-bis(bromomethyl)quinoxaline with substituents at the 6- and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed antibacterial activity. The derivative 1g, which bears a trifluoromethyl group at the 6-position, showed the highest activity against Gram-positive bacteria, while 1c, which has a fluoro-group at the 6-position, showed the widest antifungal activity spectrum. However, only the derivative with an ethyl ester substitution, 1k showed activity against Gram-negative bacteria.
authors.affiliation: Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1, Kichijoji-kitamachi, Musashino, Tokyo 180-8633, Japan.
authors.forename: Hisato
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kurita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yokoyama
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011810:Quinoxalines