title: The association of HIV viral load with indirect markers of liver injury.
abstract: This study assessed the association of HIV RNA with indirect markers of liver injury including FIB-4 index, liver enzymes and platelet counts in a high-risk Hispanic population. The data were derived from a prospective study that included 138 HIV/hepatitis C (HCV)-coinfected and 68 HIV-infected participants without hepatitis C or B co-infection (mono-infected). In unadjusted analyses, detectable HIV viral load (vs undetectable, <400 copies/mL) was associated with a 40% greater odds (OR 1.4, 95% CI: 1.1-1.9, P = 0.016) of FIB-4 > 1.45 in the HIV/HCV-coinfected group and 70% greater odds of FIB-4 > 1.45 (OR 1.7, 95% CI: 1.0-2.8; P = 0.046) in the HIV-mono-infected group. In multivariable analyses, a 1 log(10) increase in HIV RNA was associated with a median increase in FIB-4 of 12% in the HIV/HCV-coinfected group and 11% in the HIV-mono-infected group (P < 0.0001). Among the HIV/HCV-coinfected group, the elevating effect of HIV RNA on FIB-4 was strongest at low CD4 counts (P = 0.0037). Among the HIV-mono-infected group, the association between HIV RNA and FIB-4 was independent of CD4 cell counts. HIV RNA was associated with alterations in both liver enzymes and platelet counts. HIV antiretroviral therapy was not associated with any measure of liver injury examined. This study suggests that HIV may have direct, injurious effects on the liver and that HIV viral load should be considered when these indirect markers are used to assess liver function.
authors.affiliation: Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA. janet.forrester@tufts.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Forrester
authors.forename: M S
authors.initials: MS
authors.lastname: Rhee
authors.forename: B H
authors.initials: BH
authors.lastname: McGovern
authors.forename: R K
authors.initials: RK
authors.lastname: Sterling
authors.forename: T A
authors.initials: TA
authors.lastname: Knox
authors.forename: N
authors.initials: N
authors.lastname: Terrin
mesh_terms: D000328:Adult; D004798:Enzymes / Q000097:blood; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications* / Q000821:virology*; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology*; D006630:Hispanic or Latino; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
chemical_list: D004798:Enzymes; D012367:RNA, Viral