title: Mac-1 negative NK cells constitute the predominant subset in the livers of mice transvenously injected with tumor cells.
abstract: We evaluated age-related differences in hepatic natural killer (NK) cell phenotypes in juvenile (2-week-old) and adult (8-week-old) C57BL/6(B6) mice, and determined NK cell cytotoxicity and apoptosis in tumor inoculated mice. Juvenile mice had a preponderance of Mac-1(-) NK cells that exhibited significantly higher cytotoxicity levels. The Mac-1(-) NK cell population was the predominant subset in the liver of mice inoculated with the CMT-93 mouse rectum carcinoma cell line, which paralleled a dramatic decrease in the numbers of Mac-1(+) NK cells. The decrease in Mac-1(+) NK cells was driven by an apoptotic pathway.
authors.affiliation: Department of Colorectal Surgery, the Third Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Mingqi
authors.initials: M
authors.lastname: Li
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Bai
authors.forename: Xishan
authors.initials: X
authors.lastname: Wang
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D002452:Cell Count; D045744:Cell Line, Tumor; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology* / Q000556:secondary; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology; D016399:Lymphoma, T-Cell; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells / Q000166:cytology / Q000276:immunology; D012004:Rectal Neoplasms / Q000473:pathology
chemical_list: D016177:Macrophage-1 Antigen