title: Solely inhibin B producing ovarian tumour as a cause of secondary amenorrhoea with hot flushes: case report and review of literature.
abstract: In this report, we describe a case of a solely inhibin B producing fibrothecoma presenting with secondary amenorrhoea and hot flushes. Typical laboratory findings were an elevated LH, elevated inhibin B, low FSH and low estrogen. The World Health Organization classification of amenorrhoea was not applicable since the combination of low estrogen and low FSH suggested a central cause, whereas actually there was an ovarian cause. With staging laparotomy, a bilateral borderline tumour was detected in combination with a fibrothecoma. This report underpins the concept of inhibin B being a selective FSH secretion inhibitor of ovarian origin. Furthermore, a literature review on these topics is included.
authors.affiliation: Department of Obstetrics and Gynecology, Spaarne Ziekenhuis, Spaarnepoort 1, Hoofddorp, the Netherlands.
authors.forename: S W J D
authors.initials: SW
authors.lastname: van Liempt
authors.forename: L E
authors.initials: LE
authors.lastname: van Rheenen-Flach
authors.forename: J H T M
authors.initials: JH
authors.lastname: van Waesberghe
authors.forename: M C G
authors.initials: MC
authors.lastname: Bleeker
authors.forename: J M J
authors.initials: JM
authors.lastname: Piek
authors.forename: C B
authors.initials: CB
authors.lastname: Lambalk
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000150:complications*; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D019584:Hot Flashes / Q000150:complications; D006801:Humans; D007265:Inhibins / Q000097:blood / Q000378:metabolism*; D007889:Leiomyoma / Q000150:complications / Q000000981:diagnostic imaging; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone