title: Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.
abstract: Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.
authors.affiliation: Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg-CNRS (UMR 7006), 8 allee Gaspard Monge, 67000 Strasbourg, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Daguer
authors.forename: Mihai
authors.initials: M
authors.lastname: Ciobanu
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D019277:Entropy; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D010455:Peptides; D019809:Streptavidin