title: Osteosarcoma at the site of titanium orthopaedic implants in a dog.
abstract: An Alaskan Malamute underwent unilateral tibial tuberosity advancement (TTA) surgery to stabilise a stifle joint with a deficient cranial cruciate ligament. The dog made an excellent recovery with no postoperative complications, until 20 months post-surgery when he presented with acute onset ipsilateral pelvic limb lameness. Osteosarcoma (OSA) was diagnosed adjacent to the titanium implants. Currently, there is a paucity of information on the epidemiology of OSA adjacent to orthopaedic implants in canine patients. The clinical, radiological and pathological findings of this case of periprosthetic OSA, and a potential causal relationship between titanium implants and bone neoplasia, are discussed.
authors.affiliation: Adelaide Veterinary Specialist and Referral Centre, Norwood, South Australia, Australia. andrew.dunn@vetreferrals.com.au
authors.forename: A L
authors.initials: AL
authors.lastname: Dunn
authors.forename: E A
authors.initials: EA
authors.lastname: Buffa
authors.forename: D M
authors.initials: DM
authors.lastname: Hanshaw
authors.forename: M
authors.initials: M
authors.lastname: Farrell
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000473:pathology / Q000601:surgery; D001859:Bone Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D012516:Osteosarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D011183:Postoperative Complications / Q000662:veterinary; D019736:Prostheses and Implants / Q000009:adverse effects / Q000662:veterinary*; D013264:Stifle / Q000473:pathology / Q000601:surgery; D014025:Titanium / Q000009:adverse effects*
chemical_list: D014025:Titanium