title: An analytical study of relay neuron's reliability: dependence on input and model parameters.
abstract: Relay neurons are widely found in our nervous system, including the Thalamus, spinal cord and lateral geniculate body. They receive a modulating input (background activity) and a reference input. The modulating input modulates relay of the reference input. This modulation is critical for correct functioning of relay neurons, but is poorly understood. In this paper, we use a biophysical-based model and systems theoretic tools to calculate how well a single relay neuron relays a reference input signal as a function of the neuron's electro physiological properties (i.e. model parameters), the modulating signal, and the reference signal parameters. Our analysis is more rigorous than previous related works and is generalizable to all relay cells in the body. Our analytical expression matches relay performance obtained in simulation and suggest that increasing the frequency of a sinusoidal modulating input or decreasing its DC offset increases the relay cell reliability.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charels Street, Baltimore, MD 21218, USA. rahul.jhu@gmail.com
authors.forename: Rahul
authors.initials: R
authors.lastname: Agarwal
authors.forename: Sridevi V
authors.initials: SV
authors.lastname: Sarma
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D008959:Models, Neurological; D009435:Synaptic Transmission / Q000502:physiology*