title: N-heterocyclic carbene-mediated hydroacylation-Sonogashira/Heck/Suzuki coupling in a single pot: a new cascade reaction.
abstract: A dually NHC-catalyzed reaction cascade comprising an initial hydroacylation of an activated ketone and subsequent Sonogashira/Heck/Suzuki coupling in the same pot is reported. The reaction mechanism and scope of the methodology is presented.
authors.affiliation: Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, 500 049, India.
authors.forename: M
authors.initials: M
authors.lastname: Sreenivasulu
authors.forename: K Siva
authors.initials: KS
authors.lastname: Kumar
authors.forename: P Rajender
authors.initials: PR
authors.lastname: Kumar
authors.forename: K B
authors.initials: KB
authors.lastname: Chandrasekhar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000215:Acylation; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds; C030011:carbene; D008697:Methane