title: Transcranial Doppler and cerebral augmentation in acute ischemic stroke.
abstract: BACKGROUND
  Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the effect of partial aortic occlusion on arterial flow velocities of acute stroke patients.
  
  
  METHODS
  Patients with neurological deficits following thrombolysis were treated with partial aortic occlusion. Transcranial Doppler ultrasound (TCD) was used to measure arterial flow velocities at baseline, before and during balloon inflation. The augmented mean flow velocity (MFV), peak systolic velocity (PSV), and end diastolic velocity flow percentages (aMFV%, aPSV%, aEDV%) were calculated and compared based on outcome.
  
  
  RESULTS
  Of 11 patients, 3 did not have a temporal window and thus were excluded from our analysis. Six of the remaining 8 patients had middle cerebral artery (MCA) occlusions; the final 2 had terminal internal carotid artery (TICA) occlusions. Three of these 8 patients had good outcome at 90 days (mRS < 3). Before intra-aortic balloon inflation (IABI), the mean affected artery MFV was 23 ± 11 cm/s; during the procedure it was 26 ± 12 cm/s (P = .2). Mean affected artery PSV at baseline and during balloon inflation were 37 ± 16 and 46 ± 23, respectively (P = .1). Mean augmented affected artery MFV% in patients with good long-term outcome was 65.4 ± 46, while the result in those with poor outcome was -3.7 ± 21 (P = .03). Three patients developed anterior cross-filling, and of these 2 had good long-term outcome.
  
  
  CONCLUSIONS
  TCD monitoring of patients treated with IABI may help in predicting outcome in this novel device.
authors.affiliation: Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
authors.forename: Maher
authors.initials: M
authors.lastname: Saqqur
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Ken
authors.initials: K
authors.lastname: Butcher
authors.forename: Khurshid
authors.initials: K
authors.lastname: Khan
authors.forename: Derek
authors.initials: D
authors.lastname: Emery
authors.forename: Dulka
authors.initials: D
authors.lastname: Manawadu
authors.forename: Carol
authors.initials: C
authors.lastname: Derksen
authors.forename: Brenda
authors.initials: B
authors.lastname: Schwindt
authors.forename: Ashfaq
authors.initials: A
authors.lastname: Shuaib
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging*; D021721:Balloon Occlusion / Q000379:methods*; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods