title: Leukemic presentation of ALK-negative anaplastic large cell lymphoma in a patient with myelodysplastic syndrome.
abstract: A 50-year-old woman with a history of aplastic anemia developed cervical lymphadenopathy and atypical lymphocytosis. Atypical cells of lymph nodes were positive for CD3 and CD30 but negative for anaplastic lymphoma kinase (ALK). Bone marrow examination showed trilineage myelodysplasia. She was diagnosed with ALK-negative anaplastic large cell lymphoma (ALCL) with leukemic transformation and myelodysplastic syndrome (MDS) which presumably developed from aplastic anemia. The lymphoma was resistant to intensive chemotherapies, ultimately leading to death. Leukemic presentation of ALK-negative ALCL as an initial manifestation is extremely rare, and the progression of the disease may be influenced by MDS through alteration of immune functions.
authors.affiliation: Department of Hematology, Oami Hospital, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Shio
authors.initials: S
authors.lastname: Sakai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.forename: Daijiro
authors.initials: D
authors.lastname: Abe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011289:Preleukemia / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D020794:Receptor Protein-Tyrosine Kinases / Q000097:blood
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases