title: [Therapeutic angiogenesis by stem cell transplantation].
abstract: The prevalence of peripheral arterial disease(PAD) is increasing with reference to the life style related disease. Up to one third of patients are not susceptible to traditional revascularization. Therefore, new strategies are needed to offer these patients a viable therapeutic option. The discovery of endothelial progenitor cells (EPCs) in human peripheral blood advanced the field of cell-based therapeutics for many pathological conditions. Bone-marrow derived stem and progenitor cells have been identified as a potential new therapeutic option to induce angiogenesis. However, the mechanism by which cell therapy improves tissue ischemia remains obscure. The present study showed that angiogenic cytokines, especially IL-1beta, were associated with the response to treatment. It is likely that muscle cells but not implanted cells are a major source of angiogenic cytokines in ischemic limbs, thereby promoting neovascularization in ischemic tissues.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
authors.forename: Wataru
authors.initials: W
authors.lastname: Shioyama
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology; D058729:Peripheral Arterial Disease / Q000628:therapy*; D033581:Stem Cell Transplantation
chemical_list: D053583:Interleukin-1beta