title: [Effect of cholinesterase reactivator carboxim on T-lymphocyte acetylcholinesterase activity and immune response under conditions of acute intoxication by organophosphorus compounds].
abstract: It has been established in experiments on non-inbred rats that the administration of cholinesterase reactivator carboxim in a single dose of 10 mg/kg signifucantly reduces the inactivation of acetylcholinesterase in T-lymphocytes caused by acute intoxication with organophosphorus compounds (sarin, metaphos) in a dose of 1.0 LD50. The drug administration leads to partial or almost complete recovery of the humoral and cellular immune responses. Carboxim does not influence the T-independent humoral immune response reduced due to suppression of B-cell (plasmocyte) function by organophosphorus compounds.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Strel'tsova
authors.forename: V A
authors.initials: VA
authors.lastname: Grishin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D021461:Animals, Outbred Strains; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002619:Chemical Warfare Agents / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage* / Q000627:therapeutic use; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity; D051381:Rats; D012524:Sarin / Q000633:toxicity*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D008743:Methyl Parathion; D012524:Sarin; D000110:Acetylcholinesterase