title: Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Esther C Y
authors.initials: EC
authors.lastname: Woon
authors.forename: Anthony
authors.initials: A
authors.lastname: Tumber
authors.forename: Akane
authors.initials: A
authors.lastname: Kawamura
authors.forename: Lars
authors.initials: L
authors.lastname: Hillringhaus
authors.forename: Wei
authors.initials: W
authors.lastname: Ge
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Rose
authors.forename: Jerome H Y
authors.initials: JH
authors.lastname: Ma
authors.forename: Mun Chiang
authors.initials: MC
authors.lastname: Chan
authors.forename: Louise J
authors.initials: LJ
authors.lastname: Walport
authors.forename: Ka Hing
authors.initials: KH
authors.lastname: Che
authors.forename: Stanley S
authors.initials: SS
authors.lastname: Ng
authors.forename: Brian D
authors.initials: BD
authors.lastname: Marsden
authors.forename: Udo
authors.initials: U
authors.lastname: Oppermann
authors.forename: Michael A
authors.initials: MA
authors.lastname: McDonough
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D007656:Ketoglutaric Acids / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D003432:Cross-Linking Reagents; D007656:Ketoglutaric Acids; D056484:Jumonji Domain-Containing Histone Demethylases