title: Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
abstract: The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.
authors.affiliation: Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. west@neuro.duke.edu
authors.forename: Anne E
authors.initials: AE
authors.lastname: West
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008297:Male; D012201:Reward
chemical_list: D018765:Dopamine Uptake Inhibitors; D000242:Cyclic AMP; C404500:HDAC5 protein, human; D006655:Histone Deacetylases; D003042:Cocaine