title: Au(III)-catalyzed tandem amination-hydration of alkynes: synthesis of α-(N-2-pyridonyl)ketones.
abstract: A new Au(III)-catalyzed tandem amination-hydration reaction has been discovered, leading to the formation of α-(N-2-pyridonyl)ketones and heterocyclic analogues in good to excellent yields (14 examples, 48-90%). This reaction demonstrates the unusual use of a heterocyclic sp(2) nitrogen nucleophile in a gold-catalyzed 6-endo-dig cyclization. The tandem process allows rapid access to α-(N-2-pyridonyl)ketones, making them a convenient building block for the synthesis of more complex N-alkyl pyridone targets.
authors.affiliation: Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, Michigan 49546, USA.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Romero
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Klepser
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Anderson