title: A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle.
abstract: A new universal strategy exploits DKP formation in a dipeptide moiety whose C-terminal residue is blocked by a leaving group. It enables both synthesis of C-terminal protected peptides that are useful for convergent synthesis of large peptides and use of a C-terminal permanent protecting group that can be cleaved by catalytic hydrogenation to release the peptide.
authors.affiliation: Institute for Research in Biomedicine, Barcelona Science Park (PCB), Baldiri Reixac 10, 08028-Barcelona, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Góngora-Benítez
authors.forename: Michèle
authors.initials: M
authors.lastname: Cristau
authors.forename: Matthieu
authors.initials: M
authors.lastname: Giraud
authors.forename: Judit
authors.initials: J
authors.lastname: Tulla-Puche
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D057930:Click Chemistry; D006865:Hydrogenation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D010455:Peptides