title: Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.
abstract: BACKGROUND
  Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse.
  
  
  OBJECTIVE
  To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking.
  
  
  METHODS
  One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning.
  
  
  RESULTS
  Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study (n = 30) further indicated that the effect of yohimbine was specific to reacquisition.
  
  
  CONCLUSIONS
  The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse.
authors.affiliation: Department of Psychology, University of Guelph, 50 Stone Rd. E, Guelph, ON, N1W 2G1, Canada.
authors.forename: Amanda T
authors.initials: AT
authors.lastname: Campbell
authors.forename: Daniela
authors.initials: D
authors.lastname: Kwiatkowski
authors.forename: Emily
authors.initials: E
authors.lastname: Boughner
authors.forename: Francesco
authors.initials: F
authors.lastname: Leri
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000209:etiology*; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological; D004305:Dose-Response Relationship, Drug; D008297:Male; D009293:Opioid-Related Disorders / Q000534:rehabilitation; D010098:Oxycodone / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D012646:Self Administration; D013315:Stress, Psychological / Q000523:psychology*; D015016:Yohimbine / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D015016:Yohimbine; D010098:Oxycodone