title: Compact wireless neural recording system for small animals using silicon-based probe arrays.
abstract: This paper reports on a compact, small-scale neural recording system combining state-of-art silicon-based probe arrays with a light-weight 32-channel wireless head stage. The system is equipped with two- and four-shaft, comb-shaped probe arrays connected to highly flexible ribbon cables enabling a reliable and controlled insertion of probe arrays through the intact dura mater into the medial prefrontal cortex and nucleus accumbens of rats. The in vivo experiments applied the 5-choice serial reaction time task (5-CSRTT) using freely behaving rats in order to understand the neural basis of sustained visual attention and impulsivity. The long-term stability of the system allowed local field potential (LFP) activity to be recorded without a significant decrement in signal quality for up to 28 weeks, and similarly, we were able to follow single unit activity for up to 4 weeks.
authors.affiliation: Department of Microsystems Engineering, University of Freiburg, Germany. ruther@imtek.de
authors.forename: Patrick
authors.initials: P
authors.lastname: Ruther
authors.forename: Tobias
authors.initials: T
authors.lastname: Holzhammer
authors.forename: Stanislav
authors.initials: S
authors.lastname: Herwik
authors.forename: P Dylan
authors.initials: PD
authors.lastname: Rich
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Dalley
authors.forename: Oliver
authors.initials: O
authors.lastname: Paul
authors.forename: Tahl
authors.initials: T
authors.lastname: Holtzman
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D017076:Computer-Aided Design; D004566:Electrodes; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis / Q000295:instrumentation; D008904:Miniaturization; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013686:Telemetry / Q000295:instrumentation*