title: Carotid-radial pulse wave velocity as a discriminator of intrinsic wall alterations during evaluation of endothelial function by flow-mediated dilatation.
abstract: Flow-mediated dilatation (FMD) is the most accepted technique for the evaluation of endothelial function. However, it has been show a great inter-subject variability limiting its clinical use. Carotid-radial pulse wave velocity (PWVcr) was proposed as an alternative tool for the evaluation of endothelial function. At the present, there is no doubt that PWVcr reduces its values in response to reactive hyperemia test (RHT) in healthy subjects.
  
  
  OBJECTIVE
  a) to determine simultaneously the temporal profile of FMD, PWVcr and shear rate in response to RHT and b) to describe and analyze how subjects "FMD responders" or "non-responders" behave regards to PWVcr changes.
  
  
  METHODS
  34 Healthy young subjects were included. The PWVcr (strain gauge mechanotransducers), brachial diameter (B-Mode ultrasound and blood flow velocity (Doppler ultrasound) were measured before (baseline) the cuff was inflated and after its deflation (5 minutes). 10(th) percentiles FMD and PWVcr changes in the population were used for the definition of the subjects ("responders and non-responders").
  
  
  RESULTS
  Changes in PWVcr, brachial arterial diameter and shear rate were evidenced after the cuff release (p<0.05). There were differences in the PWV and FMD temporal profiles. Within "FMD responders" there were "PWV responders and non-responders".
  
  
  CONCLUSIONS
  Assessing RHT-related changes in PWVcr in the context of a FMD evaluation, could be useful as a discriminator of intrinsic wall alterations giving additional information of vascular dynamics.
authors.affiliation: CUiiDARTE and the Physiology Department, School of Medicine, Universidad de la República, General Flores 2125, PC:11800 Montevideo, Uruguay.
authors.forename: J
authors.initials: J
authors.lastname: Torrado
authors.forename: D
authors.initials: D
authors.lastname: Bia
authors.forename: Y
authors.initials: Y
authors.lastname: Zócalo
authors.forename: I
authors.initials: I
authors.lastname: Farro
authors.forename: F
authors.initials: F
authors.lastname: Farro
authors.forename: M
authors.initials: M
authors.lastname: Valero
authors.forename: R L
authors.initials: RL
authors.lastname: Armentano
mesh_terms: D000328:Adult; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure; D001916:Brachial Artery / Q000473:pathology; D002319:Cardiovascular System; D002339:Carotid Arteries / Q000473:pathology*; D004106:Dilatation; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000473:pathology; D008297:Male; D033081:Shear Strength; D013314:Stress, Mechanical; D013997:Time Factors; D014664:Vasodilation / Q000502:physiology