title: The negative effect of combining rhBMP-2 and Bio-Oss on bone formation for maxillary sinus augmentation.
abstract: Sinus augmentation with various bone graft materials may be required in the posterior maxilla. This study compared bone formation in a lateral window sinus augmentation with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ACS) combined with Bio-Oss or Bio-Oss graft alone. Patients were assigned to treatment with either rhBMP-2/ACS + Bio-Oss or Bio-Oss alone. After a healing period, bone cores were harvested. Histologic specimens demonstrated that new bone formation was less in those who received rhBMP-2/ACS + Bio-Oss than those with Bio-Oss alone. This study indicated that the addition of rhBMP-2/ACS to Bio-Oss has a negative effect on bone formation.
authors.affiliation: Department of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. drdankao@gmail.com
authors.forename: Daniel W K
authors.initials: DW
authors.lastname: Kao
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubota
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Fiorellini
mesh_terms: D000328:Adult; D000368:Aged; D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000494:pharmacology; D011994:Recombinant Proteins; D059546:Sinus Floor Augmentation / Q000379:methods*; D017768:Skin, Artificial
chemical_list: C077540:Bio-Oss; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D004338:Drug Combinations; D008903:Minerals; D011994:Recombinant Proteins