title: Protective effects of Ginkgo biloba extract on ligature-induced periodontitis in rats.
abstract: OBJECTIVE
  The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model.
  
  
  METHODS
  Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group.
  
  
  RESULTS
  Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05).
  
  
  CONCLUSIONS
  The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. ufuxezer@yahoo.com
authors.forename: Ufuk
authors.initials: U
authors.lastname: Sezer
authors.forename: Muhammet İsa
authors.initials: Mİ
authors.lastname: Kara
authors.forename: Kamile
authors.initials: K
authors.lastname: Ercıyas
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Kemal
authors.initials: K
authors.lastname: Üstün
authors.forename: Hatice
authors.initials: H
authors.lastname: Ozer
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Göze
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D020441:Ginkgo biloba; D008297:Male; D009967:Orthodontic Appliances / Q000009:adverse effects*; D010518:Periodontitis / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts