title: Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001.
abstract: Molluscum contagiosum virus (MCV) is a poxvirus that causes localized papules in healthy persons. We evaluated a woman with severe immunodeficiency and disseminated MCV. During treatment with CMX-001, an antiviral with activity against other poxviruses, MCV DNA was detected in 20% of plasma samples. When the patient was not receiving CMX-001, MCV DNA was detected in 50% of samples. We also noted improvement in warts on her fingers during CMX-001 therapy. Although MCV is caused by direct inoculation of virus into skin in healthy persons, in a severely immunocompromised person MCV DNA was present in blood and may spread by viremia.
authors.affiliation: Medical Virology Section, Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8007, USA.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Cohen
authors.forename: Wilmer
authors.initials: W
authors.lastname: Davila
authors.forename: Mir A
authors.initials: MA
authors.lastname: Ali
authors.forename: Siu-Ping
authors.initials: SP
authors.lastname: Turk
authors.forename: Edward W
authors.initials: EW
authors.lastname: Cowen
authors.forename: Alexandra F
authors.initials: AF
authors.lastname: Freeman
authors.forename: Kening
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D057176:Compassionate Use Trials; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D008976:Molluscum Contagiosum / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D008977:Molluscum contagiosum virus; D063065:Organophosphonates / Q000627:therapeutic use*; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; C525733:brincidofovir; D003596:Cytosine