title: Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: improvement of production parameters and interaction with maternally derived immunity.
abstract: The present study describes the effects of a commercially available vaccine against Porcine circovirus type 2 (PCV2) on clinical, pathological and virological outcomes of 3-week-old piglets from two farms with a clinical history of postweaning multisystemic wasting syndrome (PMWS). The study was a controlled, double-blinded, parallel group (1:1) and randomized trial (with a negative control) involving a total of 1239 animals. The study period comprised from weaning age (time of vaccination or PBS inoculation) until the first shipment of pigs to the slaughterhouse. The vaccine product was able to reduce clinical signs, PCV2 viral load in sera and faeces, and overall mortality in nurseries and fattening units. Moreover, average daily gain was significantly higher in vaccinated versus non-vaccinated piglets during the trial period. On the other hand, it was shown that maternally derived antibodies interfered with the development of an active humoral immune response after PCV2 vaccination.
authors.affiliation: Centre de Recerca en Sanitat Animal, UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fraile
authors.forename: Llorenç
authors.initials: L
authors.lastname: Grau-Roma
authors.forename: Patxi
authors.initials: P
authors.lastname: Sarasola
authors.forename: Nuria
authors.initials: N
authors.lastname: Sinovas
authors.forename: Miquel
authors.initials: M
authors.lastname: Nofrarías
authors.forename: Rosa
authors.initials: R
authors.lastname: López-Jimenez
authors.forename: Sergio
authors.initials: S
authors.lastname: López-Soria
authors.forename: Marina
authors.initials: M
authors.lastname: Sibila
authors.forename: Joaquim
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001835:Body Weight; D018173:Circoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017925:Circovirus / Q000276:immunology* / Q000472:pathogenicity; D004311:Double-Blind Method; D005260:Female; D056724:Immunity, Humoral; D007112:Immunity, Maternally-Acquired; D008297:Male; D053570:Porcine Postweaning Multisystemic Wasting Syndrome / Q000276:immunology / Q000517:prevention & control*; D013552:Swine / Q000276:immunology* / Q000821:virology; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D019562:Viral Load; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines