title: Inhibition of transforming growth factor beta-1 augments liver regeneration after partial portal vein ligation in a porcine experimental model.
abstract: OBJECTIVE
  TGF-β1 is a pleiotropic cytokine that is over expressed in terminal phase of liver regeneration.
  
  
  METHODS
  Twenty-four hours after partial portal vein ligation monoclonal antibody against TGF-β1 (TGF-β1 group, 7 piglets) or physiological solution (control group, 9 piglets) were applied into the central venous catheter. The biochemical parameters (bilirubin, urea, creatinine, alkaline phosphatase, gamma- glutamyl transferase, cholinesterase, aspartate aminotransferase, alanine aminotransferase and albumin) were assessed. The compensatory hypertrophy of the non-occluded liver lobes was evaluated by periodic ultrasonography during the next fourteen days and by histological examination.
  
  
  RESULTS
  The acceleration of growth of the hypertrophic liver lobes was maximal between 3rd and 7th postoperative days in comparison with the control group (p<0.05). No important differences in the biochemical or studied histological parameters were proved.
  
  
  CONCLUSIONS
  The present study describes a new usage of monoclonal antibody against TGF-β1 in large animal experimental model of partial portal vein ligation.
authors.affiliation: Department of Surgery, Charles University Medical School and Teaching Hospital, Pilsen, Czech Republic. Vena.Liska@seznam.cz
authors.forename: Vaclav
authors.initials: V
authors.lastname: Liska
authors.forename: Vladislav
authors.initials: V
authors.lastname: Treska
authors.forename: Hynek
authors.initials: H
authors.lastname: Mirka
authors.forename: Jiri
authors.initials: J
authors.lastname: Kobr
authors.forename: Roman
authors.initials: R
authors.lastname: Sykora
authors.forename: Tomas
authors.initials: T
authors.lastname: Skalicky
authors.forename: Alan
authors.initials: A
authors.lastname: Sutnar
authors.forename: Ondrej
authors.initials: O
authors.lastname: Vycital
authors.forename: Jan
authors.initials: J
authors.lastname: Bruha
authors.forename: Pavel
authors.initials: P
authors.lastname: Pitule
authors.forename: Alena
authors.initials: A
authors.lastname: Chlumska
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Racek
authors.forename: Jan
authors.initials: J
authors.lastname: Benes
authors.forename: Lubos
authors.initials: L
authors.lastname: Holubec
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D006984:Hypertrophy; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects*; D023421:Models, Animal; D011169:Portal Vein / Q000601:surgery*; D013552:Swine; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D053773:Transforming Growth Factor beta1