title: The diverse and complex roles of NF-κB subunits in cancer.
abstract: It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-κB activation, it is now becoming clear that the inhibitor of NF-κB kinases (IKKs), which regulate NF-κB activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-κB subunits.
authors.affiliation: Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Catherine Cookson Building, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK. neil.perkins@ncl.ac.uk
authors.forename: Neil D
authors.initials: ND
authors.lastname: Perkins
mesh_terms: D016147:Genes, Tumor Suppressor; D006801:Humans; D016328:NF-kappa B / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology*
chemical_list: D016328:NF-kappa B