title: Conserved mechanisms of Mycobacterium marinum pathogenesis within the environmental amoeba Acanthamoeba castellanii.
abstract: Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Kennedy
authors.forename: J Hiroshi
authors.initials: JH
authors.lastname: Morisaki
authors.forename: Patricia A DiGiuseppe
authors.initials: PA
authors.lastname: Champion
mesh_terms: D048248:Acanthamoeba castellanii / Q000382:microbiology*; D000199:Actins / Q000378:metabolism; D004783:Environmental Microbiology; D008264:Macrophages / Q000382:microbiology; D019910:Mycobacterium marinum / Q000472:pathogenicity*; D015800:Protozoan Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D015800:Protozoan Proteins