title: 1,4-Dioxane and ergosterol derivatives from Withania somnifera roots.
abstract: The chemical investigation on the n-hexane extract of Withania somnifera roots has yielded octacosane, oleic and stearic fatty acids, stigmasterone, stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds. The isolation of alkenyl-1,4-dioxane compound is rare, whereas the ergosterol derivative may have biogenetic significance in the lactone formation in the E ring of withanolides. The presence of a 1,4-dioxane derivative in the nonpolar extract of roots assumes importance as this type of compound has not been reported earlier from W. somnifera. The structures of new compounds were elucidated by spectroscopic methods and chemical transformations.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India. laxmisra@hotmail.com
authors.forename: Laxminarain
authors.initials: L
authors.lastname: Misra
authors.forename: Priyanka
authors.initials: P
authors.lastname: Mishra
authors.forename: Archana
authors.initials: A
authors.lastname: Pandey
authors.forename: Rajender S
authors.initials: RS
authors.lastname: Sangwan
authors.forename: Neelam S
authors.initials: NS
authors.lastname: Sangwan
mesh_terms: D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D006586:Hexanes / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D032341:Withania / Q000737:chemistry*
chemical_list: C570610:1,4-dioxo-3beta,25,26-trihydroxyergosta-24(28)-ene; C570609:2,5-dioxo-3-tetratriacont-3'-enyl-1,4-dioxane; D004146:Dioxanes; D006586:Hexanes; C026385:n-hexane; C025223:1,4-dioxane; D004875:Ergosterol