title: Anorexigenic effects of GLP-1 and its analogues.
abstract: GLP-1 receptors are expressed in the brain, especially in the regions responsible for the regulation of food intake, and intracerebroventricular injection of GLP-1 results in inhibition of food intake. Peripheral administration of GLP-1 dose-dependently enhances satiety and reduces food intake in normal and obese subjects as well as in type 2 diabetic patients. So far, the mechanisms by which GLP-1 exerts its effects are not completely clear. Interactions with neurons in the gastrointestinal tract or possibly direct access to the brain through the blood-brain barrier as observed in rats are possible and discussed in this chapter as well as a novel hypothesis based on the finding that GLP-1 is also expressed in taste cells. Finally, the role of GLP-1 receptor agonists as a possible treatment option in obesity is discussed as well as the role of GLP-1 in the effects of bariatric surgery on adiposity and glucose homeostasis.
authors.affiliation: Medizinische Klinik IV, Otfried-Müller-Str. 10, 72076 Tübingen, Germany. baptist.gallwitz@med.uni-tuebingen.de
authors.forename: Baptist
authors.initials: B
authors.lastname: Gallwitz
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001069:Appetite Regulation / Q000187:drug effects; D050110:Bariatric Surgery; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D054795:Incretins / Q000494:pharmacology*; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D018027:Receptors, Glucagon / Q000819:agonists* / Q000378:metabolism; D012528:Satiety Response / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001067:Appetite Depressants; C000593833:GLP1R protein, human; C000593835:Glp1r protein, rat; D000067757:Glucagon-Like Peptide-1 Receptor; D054795:Incretins; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1