title: Gold-catalyzed furan/yne cyclizations for the regiodefined assembly of multisubstituted protected 1-naphthols.
abstract: The gold(I)-catalyzed intramolecular cycloisomerization of furan/ynes bearing a silyloxy or allyloxy group has been developed, which provides a highly efficient access to protected 1-naphthol derivatives with enal or enone moiety. The method offers several advantages such as high stereoselectivities, mild reaction conditions, and easily accessible starting materials. In addition, the naphthyl products could be further transformed into the important benzocoumarins in a one-pot procedure.
authors.affiliation: Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, People's Republic of China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Wang
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis*; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D003374:Coumarins; D005663:Furans; D009284:Naphthols; D006046:Gold