title: [Molecular genetic mechanisms of individual sensitivity to synthetic fatty acids in case of valproic acid].
abstract: Individual sensitivity to structural analogues of free fatty acids (FFA), some of which are endocrine destructors, resulting in hormonal metabolic disturbances, was studied using valproic acid (VA) as an example. The individual sensitivity was considered by the example of polymorphism in the PPAR@g2 gene. The homozygous genotype Pro12Pro of this gene was proved to be responsible for weight gain and development of insulin resistance during VA administration, which should be kept in mind when developing the safe levels of exposure to FFA-like substances.
authors.forename: M A
authors.initials: MA
authors.lastname: Tushkanov
authors.forename: M G
authors.initials: MG
authors.lastname: Aksenova
authors.forename: O O
authors.initials: OO
authors.lastname: Sinitsyna
authors.forename: A S
authors.initials: AS
authors.lastname: Chukanova
authors.forename: S G
authors.initials: SG
authors.lastname: Burd
authors.forename: E V
authors.initials: EV
authors.lastname: Krikova
mesh_terms: D004247:DNA / Q000235:genetics; D003627:Data Interpretation, Statistical; D052244:Endocrine Disruptors / Q000009:adverse effects*; D006579:Heterozygote; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014635:Valproic Acid / Q000009:adverse effects*; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics
chemical_list: D052244:Endocrine Disruptors; D007328:Insulin; D047495:PPAR gamma; D014635:Valproic Acid; D004247:DNA