title: Ischaemic colitis during interferon treatment for chronic hepatitis C: report of two cases and literature review.
abstract: Ischaemic colitis is known to be a severe emergency complication of interferon (IFN) therapy. However, as ischaemic colitis is an infrequent complication of IFN therapy, limited information is available regarding the safety of resuming IFN therapy after resolution of ischaemic colitis and subsequent recurrence. Here, we report two cases of ischaemic colitis during IFN therapy for chronic hepatitis C. Ischaemic colitis was fully healed within 1 week after its onset and IFN withdrawal, and IFN therapy was resumed following patients' wishes to do so. Ischaemic colitis did not recur after the resumption of IFN therapy, and sustained virological response was achieved in both patients. In this report, we also summarize the findings of 11 cases of IFN-associated ischaemic colitis (nine previously published cases plus our two cases) and review the clinical characteristics of ischaemic colitis during IFN therapy in patients with chronic hepatitis C.
authors.affiliation: Department of Digestive Disease Information & Research, Kurume University School of Medicine, Kurume, Japan. takumi@med.kurume-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Ide
authors.forename: M
authors.initials: M
authors.lastname: Itou
authors.forename: M
authors.initials: M
authors.lastname: Suetsugu
authors.forename: S
authors.initials: S
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Sakata
authors.forename: E
authors.initials: E
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Oriishi
authors.forename: S
authors.initials: S
authors.lastname: Sumie
authors.forename: O
authors.initials: O
authors.lastname: Tsuruta
authors.forename: M
authors.initials: M
authors.lastname: Sata
mesh_terms: D017091:Colitis, Ischemic / Q000139:chemically induced* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006651:Histocytochemistry; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects; D007372:Interferons / Q000008:administration & dosage* / Q000009:adverse effects*; D008853:Microscopy; D008875:Middle Aged; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D007155:Immunologic Factors; D007372:Interferons