title: Clinical and laboratory findings in patients with dengue associated with hepatopathy.
abstract: BACKGROUND
  Hepatic disorders caused by dengue infection may progress to severe manifestations, including mortality and morbidity. Cytokines are involved in it, such as the migration inhibitory factor of macrophages (MIF), tumor necrosis factor (TNF), natural killer cells (NK), B lymphocytes, and macrophages.
  
  
  METHODS
  This study was carried out from January to April 2007 at a public hospital from the Federal University of Mato Grosso do Sul, Campo Grande, Brazil. Sixty-eight patients were studied concerning hepatic alterations, with 56 reported having classic dengue, 6 with hemorrhagic dengue grade I, and 6 with hemorrhagic dengue grade II.
  
  
  RESULTS
  Among the 56 with classic dengue, 83.3% had aspartate aminotransferase (AST) alterations, and 69.6% had altered alanine aminotransferase (ALT). For those with hemorrhagic dengue grade I, 100% had AST alterations, and 83.3% had altered ALT. All the patients with hemorrhagic dengue grade II had AST and ALT alterations. AST variations reached 22.0 and 907.0, with an average value of 164.6. For ALT, we found variations between 25.0 and 867.0, with an average value of 166.07. There had been statistical significance between dengue clinical shapes and hepatic function markers.
  
  
  CONCLUSIONS
  We conclude that the infection was predominant in adults, females, and in those with low income and education. The liver enzymes were of larger amount in hemorrhagic dengue, but there was weak statistical evidence of the clinical manifestations and transaminases. Major signs and clinical symptoms were fever, headache, myalgia, arthralgia, weakness, severe pain behind the eyes, and rashes.
authors.affiliation: Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil. delso_nascimento@hotmail.com
authors.forename: Delso do
authors.initials: Dd
authors.lastname: Nascimento
authors.forename: Ana Rita Coimbra Motta de
authors.initials: AR
authors.lastname: Castro
authors.forename: Íris Bucker
authors.initials: ÍB
authors.lastname: Froes
authors.forename: Gláucia
authors.initials: G
authors.lastname: Bigaton
authors.forename: Éveny Cristine Luna de
authors.initials: ÉC
authors.lastname: Oliveira
authors.forename: Márcia Ferrario Janine
authors.initials: MF
authors.lastname: Dal Fabbro
authors.forename: Rivaldo Venâncio da
authors.initials: RV
authors.lastname: Cunha
authors.forename: Izaias Pereira da
authors.initials: IP
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D003715:Dengue / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000821:virology*; D008297:Male; D008875:Middle Aged; D019595:Severe Dengue / Q000097:blood / Q000150:complications; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase