title: [Chemoradiotherapy in early stage Hodgkin's lymphoma].
abstract: OBJECTIVE
  To evaluate the response to and toxicities of chemo-radiotherapy (CT-RT) in patients with early stage Hodgkin lymphoma treated in our institution.
  
  
  METHODS
  Retrospective study of 42 patients with early stage Hodgkin lymphoma treated between 2002 and 2007.
  
  
  RESULTS
  The age of patients ranges from 11 to 57 with a mean of 30.7 years; the sex-ratio is 0.8 (19 males and 23 females). There are 33 cases of nodular-sclerosing Hodgkin lymphoma, 6 of mixed cellularity, one lymphocyte-rich, one interfollicular and one granulomatous. As for the stages, 31 Hodgkin lymphomas are stage IIA, 6 stage IA, 3 bulky and 2 stage IAe. The ABVD protocol was given to 38 patients, the VBVP to 3 patients and the ABV to one patient. IFRT was used with dose ranging from 19.8 to 39.6 Gy. The acute toxicity of chemotherapy was hematologic only, grade 1 anemia accounting for 11.1% and grade 2 anemia for 14.8%, grade 1 leukopenia for 51.8%, grade 2 leukopenia for 333% and grade 3 leukopenia for 14.8%. Dysphagia, radiodermitis and radiomucositis were seen after radiotherapy, accounting for 16.5%, 4.6% and 9.1% respectively. No long-term toxicity of the combined therapy was found. During the follow-up period, one relapse occurred and no death was reported.
  
  
  CONCLUSIONS
  The overall survival (OS), the disease free survival (DFS) and the toxicities of the combined therapy CT-RT of the patients with early stage Hodgkin lymphoma stage IA and IIA treated in our institution were similar to those seen in the literature.
authors.affiliation: Services de Radiothérapie oncologique, Hôtel-Dieu de France, Beyrouth, Liban.
authors.forename: Georges
authors.initials: G
authors.lastname: Farha
authors.forename: Elie
authors.initials: E
authors.lastname: Nasr
authors.forename: Marwan
authors.initials: M
authors.lastname: Ghosn
authors.forename: Dolly Nehmé
authors.initials: DN
authors.lastname: Nasr
authors.forename: Fadi
authors.initials: F
authors.lastname: Nasr
authors.forename: Joseph
authors.initials: J
authors.lastname: Kattan
authors.forename: Fares
authors.initials: F
authors.lastname: Azoury
authors.forename: Philippe
authors.initials: P
authors.lastname: Aftimos
authors.forename: Georges
authors.initials: G
authors.lastname: Chahine
mesh_terms: D000328:Adult; D059248:Chemoradiotherapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies