title: Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-κB.
abstract: We compared the effects of NF-κB inhibitor aurothiomalate and voltaren on NO production by mouse macrophages in vitro, their ability to cause local edema at the site of injection, and their effect on carrageenan-induced inflammation. High concentrations of aurothiomalate reduced NO production, while in low concentrations both aurothiomalate and voltaren stimulated this process. When injected into mouse footpad, aurothiomalate in a dose >1 mM and voltaren in a dose >1.6 μM induce paw edema. Both compounds suppressed carrageenan-induced inflammation, but the efficacy of aurothiomalate 2-fold exceeded that of voltaren.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Siberian Branch, Tomsk, Russia. belsky59@mail.ru
authors.forename: Yu P
authors.initials: YP
authors.lastname: Belsky
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: N V
authors.initials: NV
authors.lastname: Belska
authors.forename: A A
authors.initials: AA
authors.lastname: Ligatcheva
authors.forename: E G
authors.initials: EG
authors.lastname: Uchasova
authors.forename: D V
authors.initials: DV
authors.lastname: Reikhart
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004008:Diclofenac / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006052:Gold Sodium Thiomalate / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D006052:Gold Sodium Thiomalate; D004008:Diclofenac; D009569:Nitric Oxide