title: Extraesophageal gastroesophageal reflux disease (GERD) symptoms are not more frequently associated with proximal esophageal reflux than typical GERD symptoms.
abstract: Extraesophageal (EE) symptoms such as cough and throat clearing are common in patients referred for reflux testing, but are less commonly associated with gastroesophageal reflux disease (GERD). Patients with reflux associated EE symptoms often lack typical GERD symptoms of heartburn and regurgitation. Our aim was to compare the frequency of proximal esophageal reflux between esophageal (typical) symptoms and EE (atypical) symptoms. Combined multichannel intraluminal impedance-pH (MII-pH) tracings were blinded by an investigator so that symptom markers were relabeled with a number without disclosure of symptom type. We selected 40 patients with at least five reflux-related symptom events for one of four symptoms (heartburn, regurgitation, cough, or throat clearing). A blinded investigator analyzed all 200 reflux episodes, reporting the proximal esophageal extent of the reflux for all symptoms. The percentage of symptom-related reflux extending proximally to 17 cm above the LES was similar among all four symptom types. At least 50% of all symptoms were associated with proximal esophageal reflux to 17 cm, with regurgitation having the highest frequency at 60%. Our data indicate that EE symptoms are not more frequently associated with proximal esophageal reflux than typical esophageal symptoms.
authors.affiliation: Medical University of South Carolina, Division of Gastroenterology and Hepatology, Charleston, South Carolina 29425, USA. robertj@musc.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Roberts
authors.forename: A
authors.initials: A
authors.lastname: Aravapalli
authors.forename: D
authors.initials: D
authors.lastname: Pohl
authors.forename: J
authors.initials: J
authors.lastname: Freeman
authors.forename: D O
authors.initials: DO
authors.lastname: Castell
mesh_terms: D000704:Analysis of Variance; D003371:Cough / Q000209:etiology*; D050782:Esophageal pH Monitoring; D005750:Gastric Juice / Q000737:chemistry; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006356:Heartburn / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057045:Laryngopharyngeal Reflux / Q000209:etiology; D010608:Pharyngeal Diseases / Q000209:etiology*; D010992:Plethysmography, Impedance; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016037:Single-Blind Method
chemical_list: D054328:Proton Pump Inhibitors