title: Computed tomography perfusion study of hemodynamic changes and portal hyperperfusion in a rabbit model of small-for-size liver.
abstract: BACKGROUND
  Portal hyperperfusion in the small-for-size (SFS) liver can threaten survival of rabbits. Therefore, it is important to understand the hemodynamic changes in the SFS liver.
  
  
  METHODS
  Twenty rabbits were divided into two groups: a control group and a modulation group. The control group underwent an extended hepatectomy. The modulation group underwent the same procedure plus splenectomy to reduce portal blood flow. CT perfusion examinations were performed on all rabbits before and after operation. Perfusion parameter values, especially portal vein perfusion (PVP), were analyzed.
  
  
  RESULTS
  PVP in the modulation group was lower than in the control group after operation (P=0.002). In the control group, postoperative PVP increased by 193.7+/-55.1% compared with preoperative PVP. A weak correlation was found between the increased percentage of PVP and resected liver-to-body weight ratio (RLBWR) (r=0.465, P=0.033). In the modulation group, postoperative PVP increased by 101.4+/-32.5%. No correlation was found between the increased percentage of PVP and RLBWR (r=0.167, P=0.644). Correlations were found between PVP and serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin after surgery (P<0.05).
  
  
  CONCLUSIONS
  We successfully evaluated the characteristics of hemodynamic changes as well as the effects of splenectomy in the SFS liver in rabbits by the CT technique.
authors.affiliation: Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Zhuang
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Xu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Qian
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Jia-Chang
authors.initials: JC
authors.lastname: Chi
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D006439:Hemodynamics; D006498:Hepatectomy / Q000009:adverse effects*; D008102:Liver Circulation; D008111:Liver Function Tests; D008297:Male; D055420:Perfusion Imaging / Q000379:methods*; D011169:Portal Vein / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011817:Rabbits; D013156:Splenectomy; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin