title: Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury.
abstract: Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.
authors.affiliation: SYGNIS Bioscience, Heidelberg, Germany.
authors.forename: Tanjew
authors.initials: T
authors.lastname: Dittgen
authors.forename: Claudia
authors.initials: C
authors.lastname: Pitzer
authors.forename: Christian
authors.initials: C
authors.lastname: Plaas
authors.forename: Friederike
authors.initials: F
authors.lastname: Kirsch
authors.forename: Gerhard
authors.initials: G
authors.lastname: Vogt
authors.forename: Rico
authors.initials: R
authors.lastname: Laage
authors.forename: Armin
authors.initials: A
authors.lastname: Schneider
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor