title: Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth.
abstract: One industrially important metal oxide nanoparticle (NP) is cadmium oxide (CdO). A study was performed using timed-pregnant CD-1 mice to determine if Cd associated with inhaled CdO NP could reach the placenta and adversely affect the developing fetus and/or neonate. Pregnant mice were exposed by inhalation either every other day to 100 μg of freshly generated CdO/m(3) (exposure 1) or daily to 230 μg CdO/m(3) (exposure 2). In each exposure, mice were exposed to CdO NP or carrier gas (control) for 2.5 h from 4.5 days post coitus (dpc) through 16.5 dpc. At 17.5 dpc, fetuses and placentas from both exposures 1 and 2 were collected, measured, and weighed. A subgroup from the second exposure was allowed to give birth, and neonates were weighed daily until weaning. Cadmium in the uterus and placenta, as well as in other maternal organs, was elevated in NP-treated mice, but was undetectable in fetuses at 17.5 dpc. Daily inhalation of 230 μg CdO NP/m(3) decreased the incidence of pregnancy (i.e., no evidence of implantation) by 23%, delayed maternal weight gain, altered placental weight, and decreased fetal length, as well as delayed neonatal growth. This study demonstrates that inhalation of CdO NP during pregnancy adversely affects reproductive fecundity and alters fetal and postnatal growth of the developing offspring.
authors.affiliation: Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Blum
authors.forename: Judy Q
authors.initials: JQ
authors.lastname: Xiong
authors.forename: Carol
authors.initials: C
authors.lastname: Hoffman
authors.forename: Judith T
authors.initials: JT
authors.lastname: Zelikoff
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D017931:DNA Primers; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D008297:Male; D053768:Metal Nanoparticles; D051379:Mice; D010087:Oxides / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D019187:Cadmium Compounds; D017931:DNA Primers; D010087:Oxides; D002104:Cadmium; C029663:cadmium oxide