title: Well-differentiated liposarcoma/atypical lipomatous tumor of the oral cavity: report of three cases and review of the literature.
abstract: Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.
authors.affiliation: Department of Oral Pathology and Medicine, Dental School, University of Athens, 2 Thivon Street, 11527, Athens, Greece. liapiperi@dent.uoa.gr
authors.forename: Evangelia
authors.initials: E
authors.lastname: Piperi
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tosios
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Nikitakis
authors.forename: Vasileios F
authors.initials: VF
authors.lastname: Kyriakopoulos
authors.forename: Fotios
authors.initials: F
authors.lastname: Tzerbos
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Koutlas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sklavounou
mesh_terms: D000328:Adult; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery