title: Microbiological diagnosis of spinal tuberculosis.
abstract: OBJECTIVE
  The purpose of this study was to review the clinical features and diagnosis of spinal tuberculosis cases reported in the literature.
  
  
  METHODS
  A medical literature search in the Medline Pubmed database was undertaken to review tuberculosis spinal infection and extra-pulmonary tuberculosis diagnosis improvement. We introduced the following search items and boolean operators: "spinal infection", "spinal tuberculosis infection", "microbiological diagnosis of spinal tuberculosis" and "spinal tuberculosis PCR." Single cases or series without microbiological diagnosis were rejected. Manuscript language was restricted to Spanish, French, and English versions.
  
  
  CONCLUSIONS
  Spinal tuberculosis is more common in developing countries and is probably underdiagnosed. Delayed diagnosis is characteristic; it worsens the prognosis and increases morbidity. The microbiological diagnosis is crucial for several reasons. Despite surgical treatment, medical treatment with anti-tuberculous drugs is always necessary. A total of 20-40% of the spinal tuberculosis patients show another locus of infection. Pulmonary location can become a public health problem. Previously treated patients for other tuberculosis locations, incomplete treatments, or poor adherence can change the M. tuberculosis sensitivity pattern. Drug resistance test becomes a major need in the microbiology laboratory. PCR diagnostic techniques advance the diagnosis and increase the sensitivity and specificity rate.
authors.affiliation: Clinical Microbiology Department, Clinico San Carlos Hospital, Madrid, Spain. merinopaloma@yahoo.com
authors.forename: Paloma
authors.initials: P
authors.lastname: Merino
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Candel
authors.forename: Israel
authors.initials: I
authors.lastname: Gestoso
authors.forename: Elvira
authors.initials: E
authors.lastname: Baos
authors.forename: Juan
authors.initials: J
authors.lastname: Picazo
mesh_terms: D006801:Humans; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology; D014399:Tuberculosis, Spinal / Q000175:diagnosis* / Q000382:microbiology