title: Randomized controlled trial to compare two bone substitutes in the treatment of bony dehiscences.
abstract: OBJECTIVE
  This in vivo split-mouth randomized controlled trial compared a synthetic bone substitute with a bovine bone mineral to cover bone dehiscences after implant insertion.
  
  
  METHODS
  Fourteen patients received four to six implants to support an overdenture. Two comparable dehiscences within the same patient were first covered with a layer of autogenous bone, followed by a layer of either Bio-Oss® (group 1; Geistlich Pharma AG, Wolhusen, Switzerland) or Straumann BoneCeramic® (group 2; Institut Straumann AG, Basel, Switzerland) and sealed by a resorbable membrane. The change in vertical dimension of the defect was measured at implant placement and at abutment connection (6.5 months). Clinical and radiological parameters were evaluated up to 1 year of loading.
  
  
  RESULTS
  The vertical size of the defect at surgery was 6.4 ± 1.6 mm for group 1 and 6.4 ± 2.2 mm for group 2 sites, measured from the implant shoulder. After 6.5 months, the depth of the defect was reduced to 1.5 ± 1.2 mm and 1.9 ± 1.2 mm for group 1 and group 2 sites, respectively (p > 0.05). No implants failed during follow-up. Mean marginal bone loss over the SLActive surface was 0.94 mm (group 1), 0.81 mm (group 2), and 0.93 mm (group 3, no dehiscence) after 1 year of loading.
  
  
  CONCLUSIONS
  Both bone substitutes behaved equally effectively.
authors.affiliation: Department of Periodontology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
authors.forename: Nele
authors.initials: N
authors.lastname: Van Assche
authors.forename: Sofie
authors.initials: S
authors.lastname: Michels
authors.forename: Ignace
authors.initials: I
authors.lastname: Naert
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology; D064592:Autografts / Q000637:transplantation; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D059605:Dental Implant-Abutment Design; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D011446:Prospective Studies; D011859:Radiography; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; C558777:BoneCeramic; D015921:Dental Implants; D006882:Hydroxyapatites; D008567:Membranes, Artificial; D008903:Minerals