title: Treatment with carotid angioplasty stent placement for post-stroke depression compared to antidepressants.
abstract: OBJECTIVE
  To elucidate the differences between carotid angioplasty stent placement (CAS) and antidepressants on post-stroke depression (PSD) in high-grade carotid artery stenosis patients.
  
  
  METHODS
  In this prospective, controlled study, 182 cerebral ischemia stroke patients with high-grade carotid artery stenosis who were admitted to the Southwest Hospital of the Third Military Medical University, Chongqing, China, between April 2004 and March 2009 were enrolled. Based on different treatments, the patients were assigned to 2 groups: the CAS group (n=104), and the selective serotonin reuptake inhibitors (SSRIs) group (n=78). All patients were tested using the Hamilton Depression Rating Scale (HDRS) and the National Institutes of Health Stroke Scale (NIHSS) before treatment, one, and 3 months after treatment.
  
  
  RESULTS
  The NIHSS score of the CAS group was significantly decreased at one (p=0.007) and 3 months (p=0.006). At one month, the HDRS score of the CAS group was significantly lower than the SSRIs group (p=0.005), and there was no significant difference between these 2 groups at 3 months.
  
  
  CONCLUSIONS
  The CAS relieved PSD and improved neurologic rehabilitation in high-grade carotid artery stenosis patients, and the therapeutic effect was superior to that of SSRIs after one month.
authors.affiliation: Department of Neurology of Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Heqing
authors.initials: H
authors.lastname: Huang
authors.forename: Kangning
authors.initials: K
authors.lastname: Chen
authors.forename: Tianyou
authors.initials: T
authors.lastname: Guo
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Qu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhou
authors.forename: Guojun
authors.initials: G
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000379:methods*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000601:surgery; D016893:Carotid Stenosis / Q000601:surgery*; D002681:China; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D015607:Stents; D020521:Stroke / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors