title: Synthesis and biological evaluation of formazan derivatives.
abstract: The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, (1)H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.
authors.affiliation: Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim, India.
authors.forename: Gurusamy
authors.initials: G
authors.lastname: Mariappan
authors.forename: Rejaul
authors.initials: R
authors.lastname: Korim
authors.forename: Nand Madhwa
authors.initials: NM
authors.lastname: Joshi
authors.forename: Faruk
authors.initials: F
authors.lastname: Alam
authors.forename: Rajib
authors.initials: R
authors.lastname: Hazarika
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.forename: Tiewlasubon
authors.initials: T
authors.lastname: Uriah