title: Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers.
abstract: A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.
authors.affiliation: Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33124, USA.
authors.forename: Erika L
authors.initials: EL
authors.lastname: Smith
authors.forename: Adrienne S
authors.initials: AS
authors.lastname: Brown
authors.forename: Edward
authors.initials: E
authors.lastname: Adjaye-Mensah
authors.forename: James N
authors.initials: JN
authors.lastname: Wilson
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D019281:Dimerization; D005456:Fluorescent Dyes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D005456:Fluorescent Dyes; D050484:Norepinephrine Plasma Membrane Transport Proteins