title: In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia.
abstract: We present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are strongly correlated with the output of the biomarker's pharmacokinetic model that we have developed. Model global sensitivity analysis has shown that the measured/modeled bio-optical processes can be used for probing, in vivo, the number of neoplastic layers, the extracellular pH, the intracellular buffering efficiency and the size of the extracellular space.
authors.affiliation: Department of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece. gpap@electronics.tuc.gr
authors.forename: George
authors.initials: G
authors.lastname: Papoutsoglou
authors.forename: Antigoni
authors.initials: A
authors.lastname: Anastasopoulou
authors.forename: George
authors.initials: G
authors.lastname: Stavrakakis
authors.forename: Pat
authors.initials: P
authors.lastname: Soutter
authors.forename: Costas
authors.initials: C
authors.lastname: Balas
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D008853:Microscopy / Q000379:methods*; D008954:Models, Biological; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000175:diagnosis*