title: [Clinical significance of MRP8 and cypA expression in laryngeal squamous cell carcinoma tissues].
abstract: OBJECTIVE
  To study differential expression of MRP8, CypA protein in the patients of laryngeal squamous cell carcinoma (LSCC) and the relationship in the development of LSCC.
  
  
  METHODS
  Immunohistochemistry was used to detect the expression of MRP8,CypA protein in LSCC tissues of 41 cases and matched paraneoplastic normal tissues of 41 cases,with results compared to the clinical data to determine significance.
  
  
  RESULTS
  The expression of MRP8, CypA protein in carcinoma and normal tissues and composition of different positive grades were in statistical significance (P < 0.01). The expression levels of MRP8 were no significant correlations were identified against any parameter (age,sex and cervical lymphatic metastasis) examined (P > 0.05), but related to pathological stage (P < 0.05).
  
  
  CONCLUSIONS
  MRP8 protein is on intimate terms with different pathological differentiation stage of LSCC. MRP8, CypA protein may play an important role in the development and progression of LSCC.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Feng
authors.forename: Jianrong
authors.initials: J
authors.lastname: Zhou
authors.forename: Lianzhi
authors.initials: L
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Yu
authors.forename: Pujiang
authors.initials: P
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D040501:Calgranulin A / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D021984:Cyclophilin A / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D040501:Calgranulin A; D021984:Cyclophilin A