title: Cathepsin E (EC 3.4.23.34)--a review.
abstract: Cathepsin E belongs to the third class of enzymes - hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that of cathepsin D. In a human organism, cathepsin E occurs in: erythrocytes, thymus, dendritic cells, epithelial M cells, microglia cells, Langerhans cells, lymphocytes, epithelium of gastrointestinal tract, urinary bladder, lungs, osteoclasts, spleen and lymphatic nodes. In human cells, loci of the gene of pre-procathepsin E are located on chromosome 1 in the region 1231-32. The catalytic site of cathepsin E is two residues of aspartic acid - Asp96 and Asn281, occurring in amino acid triads with sequences DTG96-98 and DTG281-283. To date, no particular role of cathepsin E in the metabolism of proteins in normal tissues has been found. However, it is known that there are many documented pathological conditions in which overexpression of cathepsin E occurs.
authors.affiliation: Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Poland. chmichal@op.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Chlabicz
authors.forename: Marek
authors.initials: M
authors.lastname: Gacko
authors.forename: Anna
authors.initials: A
authors.lastname: Worowska
authors.forename: Radosław
authors.initials: R
authors.lastname: Lapiński
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D020134:Catalytic Domain; D020059:Cathepsin E / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004792:Enzyme Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D004792:Enzyme Precursors; C067581:procathepsin E; D020059:Cathepsin E