title: Necrotizing myopathy: clinicoserologic associations.
abstract: BACKGROUND
  Necrotizing myopathy (NM) is distinguished from idiopathic inflammatory myositis (IIM) by dominance of myofiber necrosis, lack of mononuclear inflammatory infiltrates, and presence of antibodies to signal recognition particle (SRP).
  
  
  METHODS
  The clinical features of 64 cases of NM were determined. Measurement of autoantibodies was undertaken on stored sera from 23 patients with NM. The incidence of malignancy was determined from the South Australian Cancer Registry.
  
  
  RESULTS
  NM patients showed male predominance (61%), more frequent myalgias, and higher creatine kinase (CK) levels compared with IIM patients. Patients with NM had a high incidence of systemic lupus erythematosus (SLE) (21%), hypertension (11 of 17, 65%), and diabetes mellitus (3 of 13, 23%). No patient had antibodies to SRP. NM patients showed no altered risk for malignancy compared with the South Australian population (P = 0.86).
  
  
  CONCLUSIONS
  NM is associated with SLE, hypertension, and diabetes mellitus. Comprehensive assessment of cardiovascular risk is indicated in NM, which raises the possibility of targeted interventions.
authors.affiliation: Royal Adelaide Hospital, Adelaide, Adelaide, South Australia, Australia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ellis
authors.forename: Ju
authors.initials: J
authors.lastname: Ann Tan
authors.forename: Sue
authors.initials: S
authors.lastname: Lester
authors.forename: Graeme
authors.initials: G
authors.lastname: Tucker
authors.forename: Peter
authors.initials: P
authors.lastname: Blumbergs
authors.forename: Peter
authors.initials: P
authors.lastname: Roberts-Thomson
authors.forename: Vidya
authors.initials: V
authors.lastname: Limaye
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D052283:Creatine Kinase, MM Form / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D009862:Online Systems; D013021:South Australia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D052283:Creatine Kinase, MM Form