title: Role of viruses in renal cell carcinoma.
abstract: To determine whether viral infections are related to renal cell carcinoma (RCC), we studied 49 patients with RCC (29 patients were males with age ranging from 30 to 81 years and a mean of 57.5 years; 20 patients were females with age ranging from 36 to 70 years with a mean of 58.4 years) and 16 non-neoplastic kidney patients as controls. Tissues specimens from study patients and controls were examined by nested polymerase chain reaction (PCR) to determine the presence of DNA of several viruses including human papilloma virus (HPV), Epstein-Barr virus (EBV), and polyoma viruses (BKV and JCV). Our results revealed that 7 of 49 (14.29%) RCC tissue specimens had HPV DNA compared with none of 16 non-cancer control subjects. Regarding the HPV types, all the positive results were high-risk HPV types (type 16 in three and 18 in four patients). The present study suggests that HPV infection, especially high-risk types, is associated with RCC. However, more studies are necessary to demonstrate the molecular oncogenic processes involved in this association.
authors.affiliation: Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Salehipoor
authors.forename: Abdolaziz
authors.initials: A
authors.lastname: Khezri
authors.forename: Abbas
authors.initials: A
authors.lastname: Behzad-Behbahani
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.forename: Marjan
authors.initials: M
authors.lastname: Rahsaz
authors.forename: Mahdokht
authors.initials: M
authors.lastname: Aghdaei
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Afrasiabi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000821:virology*; D016022:Case-Control Studies; D004279:DNA, Viral / Q000302:isolation & purification; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007492:Iran; D007577:JC Virus / Q000235:genetics / Q000302:isolation & purification; D007680:Kidney Neoplasms / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000150:complications / Q000821:virology; D012307:Risk Factors
chemical_list: D004279:DNA, Viral