title: Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative.
abstract: Fucoxanthin exhibits high energy transfer efficiencies to Chlorophyll a (Chl a) in photosynthesis in the sea. In order to reveal how each characteristic functional group, such as the length of the polyene chain, allene, and conjugated carbonyl groups, of this marine natural product are responsible for its remarkably efficient ability, the total synthesis of fucoxanthin by controlling the stereochemistry was achieved. The method established for fucoxanthin synthesis was successfully applied to the synthesis of the C42 longer chain analogue.
authors.affiliation: Department of Chemistry, School of Science and Tchnology, Kwansei Gakuin University, Gakuen, Sanda, Hyogo 669-1337, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kajikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okumura
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwashita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kosumi
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Katsumura
mesh_terms: D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis; D024341:Xanthophylls / Q000138:chemical synthesis*
chemical_list: D011090:Polyenes; D013450:Sulfones; D024341:Xanthophylls; C025164:fucoxanthin