title: [Study on the pharmacokinetics Oxytropis falcate total flavonoids ointment in rats].
abstract: OBJECTIVE
  To study the pharmacokinetics of Oxytropis falcate total flavonoids ointment after transdermal administration in rats.
  
  
  METHODS
  The content of 2',4'-dihydroxychalcone (TFC) in plasma was determined by high performance liquid chromatography. The concentration was determined at various time and the data was processed by 3P97.
  
  
  RESULTS
  TFC behaved as a one-compartment and a two-compartment model after transdermal administration of total Oxytropis falcate total flavonoids ointment and solution, respectively. And the C(max) of ointment was improved about 3 times compared with that of the solution.
  
  
  CONCLUSIONS
  The results show that the ointment possesses sustained release property and significantly prolong the degradation half life of TFC. The ointment is benefit to improve the analgesic and anti-inflammatory activity after transdermal administration.
authors.affiliation: Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210029, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Li
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Chen
authors.forename: Min-Ming
authors.initials: MM
authors.lastname: Qu
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Yan-Yu
authors.initials: YY
authors.lastname: Xiao
authors.forename: Bao-Chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics; D019540:Area Under Curve; D001682:Biological Availability; D047188:Chalcones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000493:pharmacokinetics; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D009824:Ointments; D033021:Oxytropis / Q000737:chemistry*; D051381:Rats; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012996:Solutions; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009824:Ointments; D012996:Solutions; C059354:2',4'-dihydroxychalcone