title: Early detection and characterization of Alzheimer's disease in clinical scenarios using Bioprofile concepts and K-means.
abstract: Alzheimer's Disease (AD) is the most common neurodegenerative disease in elderly people. There is a need for objective means to detect AD early to allow targeted interventions and to monitor response to treatment. To help clinicians in these tasks, we propose the creation of the Bioprofile of AD. A Bioprofile should reveal key patterns of a disease in the subject's biodata. We applied k-means clustering to data features taken from the ADNI database to divide the subjects into pathologic and non-pathologic groups in five clinical scenarios. The preliminary results confirm previous findings and show that there is an important AD pattern in the biodata of controls, AD, and Mild Cognitive Impairment (MCI) patients. Furthermore, the Bioprofile could help in the early detection of AD at the MCI stage since it divided the MCI subjects into groups with different rates of conversion to AD.
authors.affiliation: Signal Processing and Multimedia Communications Research Group, School of Computing and Mathematics, University of Plymouth, Plymouth PL4 8AA, UK. javier.escudero@ieee.org
authors.forename: Javier
authors.initials: J
authors.lastname: Escudero
authors.forename: John P
authors.initials: JP
authors.lastname: Zajicek
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ifeachor
mesh_terms: D000328:Adult; D000465:Algorithms; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D015415:Biomarkers / Q000378:metabolism; D016000:Cluster Analysis; D003072:Cognition Disorders / Q000628:therapy; D060825:Cognitive Dysfunction / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography / Q000379:methods; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D015415:Biomarkers