title: Detecting and tracking nonfluorescent nanoparticle probes in live cells.
abstract: Precisely imaging and tracking dynamic biological processes in live cells are crucial for both fundamental research in life sciences and biomedical applications. Nonfluorescent nanoparticles are emerging as important optical probes in live-cell imaging because of their excellent photostability, large optical cross sections, and low cytotoxicity. Here, we provide a review of recent development in optical imaging of nonfluorescent nanoparticle probes and their applications in dynamic tracking and biosensing in live cells. A brief discussion on cytotoxicity of nanoparticle probes is also provided.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: Gufeng
authors.initials: G
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Fang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods; D058948:Cell Tracking / Q000379:methods*; D002477:Cells / Q000166:cytology*; D006046:Gold / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D008853:Microscopy / Q000145:classification / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D020349:Surface Plasmon Resonance / Q000379:methods
chemical_list: D006046:Gold