title: Sentinel lymph node biopsy in patients with conjunctival and eyelid cancers:  experience in 17 patients.
abstract: OBJECTIVE
  To assess lymph node invasion through the use of sentinel lymph node biopsy (SLNB) in conjunctival and eyelid tumor patients and ascertain the impact of this technique in therapeutic management recommended by the multidisciplinary consensus committee.
  
  
  METHODS
  A single center prospective nonrandomized clinical study was conducted between January 2008 and January 2010. Seventeen patients were included: 4 (2 conjunctiva and 2 eyelid) melanomas, 4 eyelid Merkel cell tumors, 8 (2 conjunctiva, 2 eyelid, 2 eyelid and conjunctiva, 2 cornea and conjunctiva) squamous cell tumors, and 1 eyelid meibomian carcinoma. Preoperative lymphoscintigraphy was done the day before surgery to label lymph node(s). The surgical biopsy was then performed along with an extemporaneous pathological examination followed by secondary complete lymph node dissection only in instances of positive histology.
  
  
  RESULTS
  In all cases, one or more sentinel lymph nodes were identified (3-13). Two biopsies (1 Merkel cell carcinoma and 1 squamous cell carcinoma) revealed neoplastic invasion and led to complete cervical node dissection. Adjunct regional treatment was indicated for 1 melanoma, for 4 Merkel cell tumors, and for 2 squamous cell carcinomas. One false negative result was noted in the group of squamous cell carcinomas after 6 months, and it was treated. No relapse or death was observed for the other 16 patients. The mean overall follow-up was 18.2 months.
  
  
  CONCLUSIONS
  As in previous studies, we found that SLNB for eyelid and conjunctival tumors is safe and effective in identifying microscopically positive SLNs. This procedure may also revive interest in the study of cervicofacial lymphatic drainage. Our current investigation is to be expanded and extended to other medical teams.
authors.affiliation: Department of Oculoplastic Surgery, Ophtalmologie B, CHU Nancy-Brabois, Nancy, France. t.maalouf@chu-nancy.fr
authors.forename: Toufic J
authors.initials: TJ
authors.lastname: Maalouf
authors.forename: Gilles
authors.initials: G
authors.lastname: Dolivet
authors.forename: Karine S
authors.initials: KS
authors.lastname: Angioi
authors.forename: Agnes
authors.initials: A
authors.lastname: Leroux
authors.forename: Pascal
authors.initials: P
authors.lastname: Genin
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: George
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology* / Q000556:secondary*; D003230:Conjunctival Neoplasms / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000556:secondary*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011446:Prospective Studies; D021701:Sentinel Lymph Node Biopsy