title: The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
abstract: This brief review will first consider HIV associated neurocognitive disorder followed by the current understanding of its neuropathogenesis. Against this background the role of the kynurenine pathway will be detailed. Evidence both direct and indirect will be discussed for involvement of the kynurenine pathway at each step in the neuropathogenesis of HIV associated neurocognitive disorder.
authors.affiliation: St Vincent's Centre for Applied Medical Research, Sydney, University of New South Wales, Sydney, Australia. a.kandanearatchi@nhs.net
authors.forename: Apsara
authors.initials: A
authors.lastname: Kandanearatchi
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Brew
mesh_terms: D002493:Central Nervous System Diseases / Q000209:etiology* / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007737:Kynurenine / Q000378:metabolism*; D017378:Quinolinic Acid / Q000009:adverse effects*
chemical_list: D007737:Kynurenine; D017378:Quinolinic Acid