title: Interdigitating dendritic cell sarcoma of lymph node mimicking granuloma: a case report and review of the literature.
abstract: Interdigitating dendritic cell sarcoma (IDCS), is an extremely rare neoplasm. We report a case of a 77-year-old man presented with gradual lymph nodes enlargement in inguina, neck and axilla for 6 months. Biopsy revealed that part of the lymph node was replaced by several large granuloma-like nodules composed of mild atypical tumor cells, resembling epithelioid cells. Mitotic figures were hardly found. Immunohistochemistry showed that tumor cells were positive for S-100, CD68 and CD45. Ki-67 labeling index was 5%. To the best of our knowledge, this is the first case of IDCS showing granuloma-like growth pattern with mild atypical tumor cells.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, China.
authors.forename: Ziyin
authors.initials: Z
authors.lastname: Ye
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Cao
authors.forename: Hangliang
authors.initials: H
authors.lastname: Lin
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D006099:Granuloma / Q000175:diagnosis*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D009418:S100 Proteins / Q000378:metabolism; D016896:Treatment Outcome; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D017493:Leukocyte Common Antigens; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C516769:PTPRC protein, human