title: When one cell is enough.
abstract: For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secondary hosts. That clinical bone marrow transplantation is a successful treatment strategy is indirect evidence that such a cell exists in humans. To date, similar criteria have not been applied to human HSCs. However, using a humanized mouse model of xenotransplantation, a recent paper shows that single human cells can fully reconstitute the lymphomyeloid system of primary recipient animals and, in some cases, that of secondary hosts.
authors.affiliation: Regenerative Medicine Institute, National University of Ireland, University Road, Galway, Ireland. rod.ceredig@nuigalway.ie
authors.forename: Rhodri
authors.initials: R
authors.lastname: Ceredig
mesh_terms: D000818:Animals; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D039503:Integrin alpha6 / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D014183:Transplantation, Heterologous
chemical_list: D039503:Integrin alpha6