title: GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese.
abstract: rs2352028 in GPC5 has been reported to be associated with the risk of lung cancer in never-smokers. We performed a replication study in 1,045 lung cancer patients and 1,094 controls of Han Chinese origin. We found no association between rs2352028 and lung cancer/adenocarcinoma in never-smokers, but a p value of .04 (under the recessive model) was obtained between this SNP and overall lung cancer/adenocarcinoma. Our data and a recent meta-analysis suspected the possibility of rs2352028 being a risk variant of lung cancer risk in never-smokers. Our findings suggested that rs2352028 might confer a slight risk to lung cancer/adenocarcinoma.
authors.affiliation: Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Yonglan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Kan
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Niu
authors.forename: Daizhan
authors.initials: D
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Shun
authors.initials: S
authors.lastname: Lu
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D053673:Glypicans / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking
chemical_list: C106228:GPC5 protein, human; D053673:Glypicans