title: [Regenerative therapy using allogeneic mesenchymal stem cells].
abstract: The use of mesenchymal stem cells (MSC) for tissue and organ regeneration offers advantages because the MSC contain multipotent progenitor cells and reported to be immunoprivileged as well as immunosuppressive. Therefore, cell therapy with allogeneic MSC has been reported as a promising treatment for severe acute graft versus host disease (GVHD). We reported a pilot study for GVHD treatments using a small number of allogeneic MSC. We also reported that MSC can show osteogenic differentiation capability when implanted in vivo as well as cultured in vitro. Based on these findings, we attempted to use allogeneic MSC for the treatment of genetic disorder of hypophosphatasia patient. Present paper summarizes our clinical experiences of allogeneic MSC for the purpose of regenerative medicine.
authors.affiliation: Department of Orthopedics, Ookuma Hospital.
authors.forename: Hajime
authors.initials: H
authors.lastname: Ohgushi
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Arima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Taketani
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells; D014184:Transplantation, Homologous