title: Validation study of the Italian Addenbrooke's Cognitive Examination Revised in a young-old and old-old population.
abstract: OBJECTIVE
  The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke's Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population.
  
  
  METHODS
  The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4±6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (<75 years) and an old-old (≥75 years) group, in order to evaluate the sensitivity and specificity of the test in detecting dementia in different age strata of elderly subjects.
  
  
  RESULTS
  The reliability of the Italian ACE-R was extremely good (α-coefficient=0.85). Two different cutoffs were identified for young-old (cutoff 79; sensitivity 90% and specificity 80%) and old-old subjects (cutoff 60; sensitivity 82% and specificity 100%).
  
  
  CONCLUSIONS
  The Italian ACE-R is a valid screening tool to detect dementia, especially in the old-old population, which represents not only the fastest growing age group but also the group at the highest risk of dementia in Western countries.
authors.affiliation: Institute of Gerontology and Geriatrics, Department of Human and Education Science, University of Perugia, Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pigliautile
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: E
authors.initials: E
authors.lastname: Mioshi
authors.forename: S
authors.initials: S
authors.lastname: Ercolani
authors.forename: F
authors.initials: F
authors.lastname: Mangialasche
authors.forename: R
authors.initials: R
authors.lastname: Monastero
authors.forename: M F
authors.initials: MF
authors.lastname: Croce
authors.forename: S
authors.initials: S
authors.lastname: Federici
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology; D003431:Cross-Cultural Comparison; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D015140:Dementia, Vascular / Q000175:diagnosis / Q000523:psychology; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D007558:Italy; D020961:Lewy Body Disease / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D012016:Reference Values; D015203:Reproducibility of Results; D014175:Translating