title: Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
abstract: BACKGROUND
  Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.
  
  
  METHODS
  We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
  
  
  RESULTS
  We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
  
  
  CONCLUSIONS
  The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
  
  
  CONCLUSIONS
  The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk.
authors.affiliation: Department of Health Studies,University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Ningqi
authors.initials: N
authors.lastname: Hou
authors.forename: Yonglan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Eric R
authors.initials: ER
authors.lastname: Gamazon
authors.forename: Temidayo O
authors.initials: TO
authors.lastname: Ogundiran
authors.forename: Clement
authors.initials: C
authors.lastname: Adebamowo
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Nathanson
authors.forename: Susan M
authors.initials: SM
authors.lastname: Domchek
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Michael S
authors.initials: MS
authors.lastname: Simon
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.forename: Anselm
authors.initials: A
authors.lastname: Hennis
authors.forename: Barbara
authors.initials: B
authors.lastname: Nemesure
authors.forename: Suh-Yuh
authors.initials: SY
authors.lastname: Wu
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Leske
authors.forename: Stefan
authors.initials: S
authors.lastname: Ambs
authors.forename: Qun
authors.initials: Q
authors.lastname: Niu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Brandon
authors.initials: B
authors.lastname: Pierce
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Olufunmilayo I
authors.initials: OI
authors.lastname: Olopade
authors.forename: Dezheng
authors.initials: D
authors.lastname: Huo
mesh_terms: D000328:Adult; D044383:Black People / Q000706:statistics & numerical data*; D001943:Breast Neoplasms / Q000208:ethnology / Q000209:etiology*; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000208:ethnology / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D044465:White People / Q000706:statistics & numerical data*