title: Association between adiponectin gene polymorphisms and coronary artery disease across different populations.
abstract: OBJECTIVE
  Many studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the associations of +45T/G, +276G/T and -11377C/G polymorphisms in adiponectin gene with CAD susceptibility.
  
  
  METHODS
  Published literature from PubMed and EMBASE databases were searched. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed- or random-effects model.
  
  
  RESULTS
  Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for -11377C/G polymorphism were included in the meta-analysis. The overall results showed that there was a statistically significant association between -11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07-1.24).Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02-1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11-1.45). However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.
  
  
  CONCLUSIONS
  The meta-analysis indicated the significant association of -11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with CAD susceptibility. However, large-scale studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the associations in future.
authors.affiliation: Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China. liangzhou0731@163.com
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Haiyan
authors.initials: H
authors.lastname: Pan
authors.forename: Wanshui
authors.initials: W
authors.lastname: Yang
authors.forename: Weihua
authors.initials: W
authors.lastname: Shen
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Li
authors.forename: Jianguang
authors.initials: J
authors.lastname: Cai
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D003324:Coronary Artery Disease / Q000235:genetics*; D003331:Coronary Vessels / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D052242:Adiponectin