title: Histopathology of brain metastases after radiosurgery.
abstract: Histopathological investigations revealed acute-, subacute-, and chronic-type tissue responses, accompanied by inflammatory cell reaction in radiosurgery treated cerebral metastases originating from different primary cancers. Immunohistochemistry demonstrated that the preponderance of CD68-positive macrophages and CD3-positive T lymphocytes in the inflammatory infiltration developed in better controlled metastases ( > 5 months). In contrast, it was sparse or absent in poorly controlled neoplasms ( < 5 months) after radiosurgery. This inflammatory reaction may be stimulated by the ionizing energy, probably influenced by the general condition of the patients' immune system as well, and seems to play a role in local tumor control after focused radiation.
authors.affiliation: Péterfy Traumatological Center, National Institute of Neurosciences and Department of Neurological Surgery, Semmelweis University of Budapest, Budapest, Hungary. gszeifert@yahoo.co.uk
authors.forename: György T
authors.initials: GT
authors.lastname: Szeifert
authors.forename: Douglas
authors.initials: D
authors.lastname: Kondziolka
authors.forename: Marc
authors.initials: M
authors.lastname: Levivier
authors.forename: L Dade
authors.initials: LD
authors.lastname: Lunsford
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000145:classification / Q000175:diagnosis / Q000209:etiology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology