title: [What does Reelin actually do in the developing brain?].
abstract: In mammalian brains, most neuronal cells form a layer structure. This structure is established thorough correct migration of neuronal cells, and underlies proper functions of the brain. It is thus important to understand the molecular mechanism that regulates neuronal migration and layer formation. Reelin is a large secreted protein essential for neuronal migration and layer formation in mammals. Since its identification in 1995, a number of models and hypotheses have been proposed regarding Reelin function. However, tbe primary role of Reelin in the developing brain and its underlying molecular mechanism still remain unresolved. In this review, I try to summarize what is known and what we can infer about Reelin. I also mention why studying Reelin is difficult.
authors.affiliation: Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan. mhattori@phar.nagoya-cu.ac.jp
authors.forename: Mitsuhara
authors.initials: M
authors.lastname: Hattori
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000254:growth & development* / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000502:physiology*; D002465:Cell Movement; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D051379:Mice; D009415:Nerve Net / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010766:Phosphorylation; D059748:Proteolysis; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases