title: Integrated heaters for temperature control in disposable bioassay cartridges for use with portable, battery-operated instruments.
abstract: Two methods for heating fluids in microliter- to milliliter-scale reaction chambers in disposable bioassay cartridges are analyzed and compared. Inductive heating requires no electrical contact between the energy source and the cartridge and uses a very inexpensive component in the cartridge. Resistive heating with a surface mount component requires electrical interconnection, but is generally conducive to low-cost off-the-shelf components. Typical power consumption for both inductive heating and resistive heating is consistent with battery-powered operation. A finite element model for heating an injection-molded plastic cartridge with a surface-mount resistor has been developed and validated through experiments on a 40 mm × 10 mm × 7.5 mm injection molded polystyrene cartridge with embedded 1 kΩ surface-mount resistors. A model of frequency-dependent heat generation in a novel inductive heating device is also presented.
authors.affiliation: Wave 80 Biosciences, Inc, San Francisco, CA 94107, USA. luis.ortiz@wave80.com
authors.forename: Luis Ortiz
authors.initials: LO
authors.lastname: Hernandez
authors.forename: Haile
authors.initials: H
authors.lastname: Negussie
authors.forename: Laura T
authors.initials: LT
authors.lastname: Mazzola
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Laser
authors.forename: Amy
authors.initials: A
authors.lastname: Droitcour
mesh_terms: D001681:Biological Assay / Q000295:instrumentation*; D017076:Computer-Aided Design; D011211:Electric Power Supplies; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D006361:Heating / Q000295:instrumentation*; D008904:Miniaturization; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration