title: Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease characterized by recurrent attacks of fever, usually accompanied by sterile polyserositis. Although amyloidosis is the most common renal involvement, non-amyloid renal lesions, such as glomerulonephritis, have been described in patients with FMF. In this report, we present the first case of an FMF patient with heterozygous mutation of E148Q, mesangial proliferative glomerulonephritis, and no amyloidosis. While the association of mutation E148Q with renal involvement is still obscure, colchicine treatment is useful in mesangial proliferative glomerulonephritis with FMF.
authors.affiliation: Department of Internal Medicine, Erciyes University Medical School, Kayseri, Turkey. drerayeroglu@hotmail.com
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
authors.forename: Ozturk
authors.initials: O
authors.lastname: Ates
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.forename: Hulya
authors.initials: H
authors.lastname: Akgun
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
mesh_terms: D010505:Familial Mediterranean Fever / Q000150:complications* / Q000235:genetics*; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D009154:Mutation; D055815:Young Adult