title: Role of mindin in diabetic nephropathy.
abstract: A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo 113-8421, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Murakoshi
authors.forename: Tomohito
authors.initials: T
authors.lastname: Gohda
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Funabiki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Horikoshi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000473:pathology / Q000652:urine; D003928:Diabetic Nephropathies / Q000276:immunology / Q000473:pathology / Q000652:urine*; D016326:Extracellular Matrix Proteins / Q000276:immunology / Q000652:urine*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000652:urine; D008297:Male; D051379:Mice; D051381:Rats; D051192:Receptors, Pattern Recognition / Q000276:immunology
chemical_list: D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D051192:Receptors, Pattern Recognition; C121491:mindin