title: A dog model of pancreaticojejunostomy without duct-to-mucosa anastomosis.
abstract: BACKGROUND
  Various anastomosis techniques have been introduced for the safe pancreaticoenterostomy. Objective In the present study, we developed an experimental animal model for simple pancreaticojejunostomy and evaluated the feasibility, safety, and efficacy of this technique.
  
  
  METHODS
  Ten dogs were studied.
  
  
  METHODS
  The dogs underwent the simple approximation ("docking") method for pancreaticojejunostomy and were re-explored on the 30th post-operative day.
  
  
  METHODS
  After excision of the remnant pancreas with the jejunal segment of the pancreaticojejunostomy, the degrees of fibrosis in the remnant pancreas were analyzed according to the patency of the pancreaticojejunostomy.
  
  
  RESULTS
  There were no mortalities and clinically significant complications. The patency of pancreaticojejunostomy remained in six cases and was obliterated in four cases. It was noted that obliterated pancreaticojejunostomy accompanied cases with more dilated pancreatic ducts (3.1 ± 0.4 mm vs. 5.5 ± 0.6 mm, P = 0.008). The grade of pancreatic fibrosis was significantly correlated with the obliterated pancreaticojejunostomy (P = 0.038) and the size change of the remnant pancreatic duct (P = 0.040).
  
  
  CONCLUSIONS
  The suggested simple pancreaticojejunostomy method is easy and shows no evidence of significant pancreatic fistula. However, the potential risk of dysfunction in the remnant pancreas limits its possible clinical applications. The meticulous duct-to-mucosa pancreaticojejunostomy is highly preferred to manage the remnant pancreas following pancreaticoduodenectomy.
authors.affiliation: Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Jun Jeong
authors.initials: JJ
authors.lastname: Choi
authors.forename: Chang Moo
authors.initials: CM
authors.lastname: Kang
authors.forename: Ho Kyoung
authors.initials: HK
authors.lastname: Hwang
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D004285:Dogs; D005240:Feasibility Studies; D005355:Fibrosis; D007413:Intestinal Mucosa / Q000601:surgery*; D023421:Models, Animal; D010179:Pancreas / Q000473:pathology / Q000601:surgery*; D010183:Pancreatic Ducts / Q000601:surgery*; D010193:Pancreaticojejunostomy / Q000379:methods*; D015203:Reproducibility of Results