title: Phylogenetic analysis of Chinese sheeppox and goatpox virus isolates.
abstract: BACKGROUND
  Sheeppox virus (SPPV) and goatpox virus (GTPV), members of the Capripoxvirus genus of the Poxviridae family are causative agents of sheep pox and goat pox respectively, which are important contagious diseases and endemic in central and northern Africa, the Middle and Far East, and the Indian sub-continent. Both sheep pox and goat pox can cause wool and hide damage, and reduce the production of mutton and milk, which may result in significant economic losses and threaten the stockbreeding. In this study, three SPPVs and two GTPVs were collected from China in 2009 and 2011. We described the sequence features and phylogenetic analysis of the P32 gene, GPCR gene and RPO30 gene of the SPPVs and GTPVs to reveal their genetic relatedness.
  
  
  RESULTS
  Sequence and phylogenetic analysis showed that there was a close relationship among SPPV/GanS/2/2011/China, SPPV/GanS/1/2011/China and SPPV/NingX/2009/China. They were clustered on the same SPPV clade. GTPV/HuB/2009/China and GS-V1 belonged to the GTPV lineage. GS-V1 was closely related to other GTPV vaccine strains. GTPV/HuB/2009/China and GS-V1 were clustered with GTPVs from China and some southern Asian countries.
  
  
  CONCLUSIONS
  This study may expand the datum for spread trend research of Chinese SPPVs and GTPVs, meanwhile provide theoretical references to improve the preventive and control strategy.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agricultural Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Huaijie
authors.initials: H
authors.lastname: Jia
authors.forename: Guohua
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaobing
authors.initials: X
authors.lastname: He
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Fang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wang
authors.forename: Qisai
authors.initials: Q
authors.lastname: Guan
authors.forename: Shuang
authors.initials: S
authors.lastname: Zeng
authors.forename: Qing
authors.initials: Q
authors.lastname: Cui
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Jing
mesh_terms: D000818:Animals; D018151:Capripoxvirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D015511:Goat Diseases / Q000453:epidemiology* / Q000821:virology*; D006041:Goats; D008969:Molecular Sequence Data; D010802:Phylogeny; D011213:Poxviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins