title: Effect of Delonix regia leaf extract on glucose tolerance in glucose-induced hyperglycemic mice.
abstract: Delonix regia (Fabaceae) leaf is used in folk medicine of Bangladesh for the treatment of diabetes, but so far no scientific study has been done which may support its use in traditional medicine. The present study was carried out to evaluate the possible glucose tolerance efficacy of methanolic extract of Delonix regia leaf using glucose-induced hyperglycemic mice. The extract at different doses was administered one hr prior to glucose administration and blood glucose level was measured after two hrs of glucose administration (p.o.) using glucose oxidase method. The statistical data indicated significant oral hypoglycemic activity on glucose-loaded mice at every dose. Maximum anti-hyperglycemic activity was showed at 400 mg/kg which was comparable to that of a standard drug, glibenclamide (10 mg/kg). The methanolic extract of leaf of Delonix regia had beneficial effects in reducing the elevated blood glucose level of hyperglycemic mice.
authors.affiliation: Department of Biotechnology and Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh.
authors.forename: Mahafuzur
authors.initials: M
authors.lastname: Rahman
authors.forename: Nazmul
authors.initials: N
authors.lastname: Hasan
authors.forename: Asish Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Tozammal
authors.initials: T
authors.lastname: Hossain
authors.forename: Rownak
authors.initials: R
authors.lastname: Jahan
authors.forename: Afsana
authors.initials: A
authors.lastname: Khatun
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rahmatullah
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D005905:Glyburide / Q000494:pharmacology / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005905:Glyburide