title: Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses.
abstract: BACKGROUND
  Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration.
  
  
  METHODS
  Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies.
  
  
  RESULTS
  We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n = 28 190 patients' data), Virtual International Stroke Trials Archive-Rehab (n = 10 194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n = 1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n = 1300), and Virtual International Stroke Trials Archive-Plus (n = 6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration.
  
  
  CONCLUSIONS
  Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.
authors.affiliation: Glasgow Caledonian University, Cowcaddens Rd, Glasgow G4 0BA, UK. vista.collaboration@glasgow.ac.uk
authors.forename: Myzoon
authors.initials: M
authors.lastname: Ali
authors.forename: Philip
authors.initials: P
authors.lastname: Bath
authors.forename: Marian
authors.initials: M
authors.lastname: Brady
authors.forename: Stephen
authors.initials: S
authors.lastname: Davis
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Donnan
authors.forename: Marc
authors.initials: M
authors.lastname: Fisher
authors.forename: Werner
authors.initials: W
authors.lastname: Hacke
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hanley
authors.forename: Marie
authors.initials: M
authors.lastname: Luby
authors.forename: G
authors.initials: G
authors.lastname: Tsivgoulis
authors.forename: Nils
authors.initials: N
authors.lastname: Wahlgren
authors.forename: Steven
authors.initials: S
authors.lastname: Warach
authors.forename: Kennedy R
authors.initials: KR
authors.lastname: Lees
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications / Q000453:epidemiology; D002986:Clinical Trials as Topic; D003142:Communication; D003625:Data Collection; D016208:Databases, Factual; D003952:Diagnostic Imaging; D006801:Humans; D012042:Registries; D020521:Stroke / Q000188:drug therapy* / Q000517:prevention & control / Q000628:therapy; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome