title: Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.
abstract: Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.
authors.affiliation: Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA. hedderic@ohsu.edu
authors.forename: Erika L
authors.initials: EL
authors.lastname: Finanger
authors.forename: Barry
authors.initials: B
authors.lastname: Russman
authors.forename: Sean C
authors.initials: SC
authors.lastname: Forbes
authors.forename: William D
authors.initials: WD
authors.lastname: Rooney
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Walter
authors.forename: Krista
authors.initials: K
authors.lastname: Vandenborne
mesh_terms: D015415:Biomarkers; D003287:Contrast Media; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D018482:Muscle, Skeletal / Q000473:pathology*; D020388:Muscular Dystrophy, Duchenne / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015415:Biomarkers; D003287:Contrast Media