title: Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer.
abstract: OBJECTIVE
  To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).
  
  
  METHODS
  A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed.
  
  
  RESULTS
  There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%).
  
  
  CONCLUSIONS
  Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Zhong
authors.forename: Ying
authors.initials: Y
authors.lastname: Ying
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Wu
authors.forename: Can-quan
authors.initials: CQ
authors.lastname: Zhou
authors.forename: Yan-wen
authors.initials: YW
authors.lastname: Xu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Shen
authors.forename: Jin
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D016022:Case-Control Studies; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D007246:Infertility / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011256:Pregnancy Outcome; D011379:Prognosis; D020554:Sperm Injections, Intracytoplasmic; D013959:Thyroid Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating