title: [Pharmacological modulation of nitrogen oxide system in experimental chronic alcoholic intoxication in rats].
abstract: The modeling of chronic alcohol intoxication for 30 days in rats leads to an increase in the level of free metabolites of nitrogen oxide and NO-synthase with simultaneous decrease in the levels of L-arginine, catalase, and superoxide dismutase. The subsequent 14-day treatment with neuropeptide cerebroprotectors cerebrocurin, cortexin, and cerebrolysin led to normalization of the parameters of nitrogen oxide system. The maximum therapeutic activity was shown by cerebrocurin, which can be recommended for inclusion as component of alcoholic encephalopathy treatment.
authors.forename: I F
authors.initials: IF
authors.lastname: Belenichev
authors.forename: E P
authors.initials: EP
authors.lastname: Sokolik
mesh_terms: D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D021461:Animals, Outbred Strains; D001120:Arginine / Q000032:analysis / Q000378:metabolism; D002374:Catalase / Q000032:analysis / Q000378:metabolism; D045424:Complex Mixtures / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism
chemical_list: D000596:Amino Acids; D045424:Complex Mixtures; D036341:Intercellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018696:Neuroprotective Agents; D010455:Peptides; C549026:cerebrocurin; D009569:Nitric Oxide; C006952:cerebrolysin; C056590:cortexin; D001120:Arginine; D002374:Catalase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase