title: Microdosimetry applied to nanosecond pulsed electric fields: a comparison on a single cell between real and ideal waveforms.
abstract: A microdosimetric analysis using ideal and real pulses was carried out in this paper. To perform this goal, authors employed an algorithm developed recently for nsPEF based on Laplace's equation and able to take into account cell compartment dispersivity. A comparison between biphasic real and ideal waveforms was carried out. The ideal pulse induced the highest pore density efficiency, hence evidencing that a device optimization to avoid waveform degradation and losses has a fundamental impact on the performances of the delivered pulses at the single cell level.
authors.affiliation: Italian Inter-University Centre for Study of Electromagnetic Fields and Bio-systems, ENEA, Casaccia Research Centre, Rome 00123, Italy. caterina.merla@ enea.it
authors.forename: Caterina
authors.initials: C
authors.lastname: Merla
authors.forename: Alessandra
authors.initials: A
authors.lastname: Paffi
authors.forename: Francesca
authors.initials: F
authors.lastname: Apollonio
authors.forename: Philippe
authors.initials: P
authors.lastname: Leveque
authors.forename: Micaela
authors.initials: M
authors.lastname: Liberti
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology* / Q000528:radiation effects*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*