title: Preventive efficacy of oxidized dextran and pathomorphological processes in mouse lungs in avian influenza A/H5N1.
abstract: Oxidized dextran (60 kDa) exerted a pronounced preventive effect in laboratory mice infected with avian influenza subtype H5N1 A/Goose/Krasnoozerskoye/627/05 virus, which manifested in a significant increase in mouse lifetime (by 24.4%) and a decrease in mortality rate (3.3-fold). This was probably related to significant alleviation of pathological changes in the lungs and severity of hemodynamic and inflammatory complications and early fibrosis [corrected].
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. potapova@soramn.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupiy
authors.forename: T V
authors.initials: TV
authors.lastname: Sharkova
authors.forename: A V
authors.initials: AV
authors.lastname: Troitskiy
authors.forename: N G
authors.initials: NG
authors.lastname: Lusgina
authors.forename: A M
authors.initials: AM
authors.lastname: Shestopalov
mesh_terms: D000818:Animals; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D053124:Influenza A Virus, H5N1 Subtype / Q000472:pathogenicity*; D008168:Lung / Q000187:drug effects / Q000473:pathology* / Q000821:virology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology
chemical_list: D003911:Dextrans