title: Structural and functional peculiarities of mast cells in undifferentiated connective tissue dysplasia.
abstract: We performed an immunomorphological study of mast cells from undamaged skin in women with phenotypical evidence of undifferentiated connective tissue dysplasia syndrome, patients of cosmetological clinics. It was found that the numerical density of mast cells containing chymase granules in this condition 1.7-fold surpassed the corresponding parameter in patients without signs of connective tissue dysplasia syndrome, which probably was a result of compensatory and adaptive reaction aimed at activation of the synthesis of the connective tissue extracellular matrix components. It was hypothesized that increased content of chymase-positive mast cells in the skin of patients with connective tissue dysplasia syndrome contributed to the formation of associated arterial hypertension.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. luzgina@mail.ru
authors.forename: N G
authors.initials: NG
authors.lastname: Luzgina
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupiy
mesh_terms: D000328:Adult; D053818:Chymases / Q000378:metabolism*; D003238:Connective Tissue; D003594:Cytoplasmic Granules; D005260:Female; D006801:Humans; D006973:Hypertension; D008407:Mast Cells / Q000166:cytology* / Q000502:physiology; D012867:Skin / Q000166:cytology / Q000473:pathology; D012868:Skin Abnormalities / Q000378:metabolism* / Q000473:pathology*
chemical_list: D053818:Chymases