title: Are we ready for intravenous thrombolysis in acute stroke treatment in our region?
abstract: Acute stroke is the leading cause of disability in modern society. Early treatment is crucial to maximize the benefit of stroke intervention. Effective thrombolytic therapy is dependent on timely intervention and guidelines for the recommended use of recombinant tissue plasminogen activator therapy within 3 hours after onset of stroke symptoms. The aim of the study was to assess whether we are ready for the introduction of thrombolysis in our region. We investigated retrospectively the time from symptom onset to hospital arrival (delay time) for patients with acute stroke in our region. Medical histories of all patients admitted to the Department in 2006 with acute stroke symptoms were studied. Statistical analysis was performed by use of the SigmaStat (version 2.0) software. Study results showed that a very high rate of patients presented after 24 hours of stroke onset (35%); 15% of all acute ischemic stroke (AIS) patients arrived within 3 hours of stroke onset. Due to other exclusion criteria established, only 4% of all AIS patients were eligible for intravenous thrombolysis. Most patients arrived in the hospital too late to get maximum benefit from the emerging stroke therapies. This may be due to the failure to recognize signs and symptoms or the lack of awareness of the potential treatment benefits. Our further efforts should be focused on increasing public awareness of the stroke signs and symptoms and on reducing delay time.
authors.affiliation: University Department of Neurology, Dubrava University Hospital, Zagreb, Croatia. vladimira.vuletic@kbd.hr
authors.forename: Vladimira
authors.initials: V
authors.lastname: Vuletić
authors.forename: Marinko
authors.initials: M
authors.lastname: Dikanović
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Lezaić
authors.forename: Lidija
authors.initials: L
authors.lastname: Sapina
authors.forename: Drago
authors.initials: D
authors.lastname: Kadojić
mesh_terms: D000368:Aged; D005260:Female; D006760:Hospitalization; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors