title: Dynamic imaging of ictal rhythmic activity using dense-array EEG.
abstract: Electroencephalogram (EEG) is an important component of the pre-surgical evaluation in the treatment of medically intractable epilepsy. However, clinical EEG uses 19 to 32 electrodes that significantly limits its localization ability. Recent development of dense-array recording techniques has suggested that increased spatial sampling rate improves the accuracy of source localization. In the current study, we proposed a 76-channel EEG system for the long-term monitoring of epilepsy patients, and proposed a dynamic seizure imaging (DSI) technique to image the ictal rhythmic activity that may evolve through time, space and frequency. We tested the system in a cohort of 8 patients and our results show that the DSI estimated the seizure activity in good correlation with intracranial recordings, successful surgery outcomes and other clinical evidence. The proposed dense-array recording and DSI imaging approach enable a non-invasive but quantitative imaging of continuous seizure activity. The results suggest that DSI may potentially be useful to assist the pre-surgical evaluation in patients with intractable epilepsy.
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. yangx726@umn.edu
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Christopher
authors.initials: C
authors.lastname: Wilke
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brinkmann
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Worrell
authors.forename: Bin
authors.initials: B
authors.lastname: He
mesh_terms: D000328:Adult; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012535:Scalp; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult