title: Extraskeletal osteosarcoma of the breast in an adolescent girl.
abstract: Extraskeletal osteosarcoma (ESOS) is a rare malignancy, usually arising in older adults. We were unable to find reports of children or adolescents affected by an ESOS of the breast. Here, we present the case of a high-grade osteosarcoma arising in the breast of a 16-year-old girl. The tumor was treated with breast-conserving resections and adjuvant multiagent chemotherapy, based on a regimen of doxorubicin, high-dose methotrexate, cisplatin, and ifosfamide. At last follow-up, the patient was in first complete remission, 29 months after initial diagnosis.
authors.affiliation: Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Zils
authors.forename: Florian
authors.initials: F
authors.lastname: Ebner
authors.forename: Michaela
authors.initials: M
authors.lastname: Ott
authors.forename: Justus
authors.initials: J
authors.lastname: Müller
authors.forename: Daniel
authors.initials: D
authors.lastname: Baumhoer
authors.forename: Michael
authors.initials: M
authors.lastname: Greulich
authors.forename: Detlef
authors.initials: D
authors.lastname: Rehnitz
authors.forename: Andreas
authors.initials: A
authors.lastname: Rempen
authors.forename: Silvia
authors.initials: S
authors.lastname: Schaetzle
authors.forename: Miriam
authors.initials: M
authors.lastname: Wilhelm
authors.forename: Stefan
authors.initials: S
authors.lastname: Bielack
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D002804:Chondroblastoma / Q000188:drug therapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D060787:Neoplasm Grading; D012516:Osteosarcoma / Q000188:drug therapy / Q000556:secondary*; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate