title: Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C.
abstract: Switching on kinases: Synthetic caged DAG-lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade.
authors.affiliation: Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Nomura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Narumi
authors.forename: Nami
authors.initials: N
authors.lastname: Ohashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Serizawa
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Lewin
authors.forename: Peter M
authors.initials: PM
authors.lastname: Blumberg
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Furuta
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tamamura
mesh_terms: D000818:Animals; D004075:Diglycerides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008027:Light; D008954:Models, Biological; D015394:Molecular Structure; D010777:Photochemistry; D011493:Protein Kinase C / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D004075:Diglycerides; D007783:Lactones; D011493:Protein Kinase C