title: [Revival of old diagnostic markers in the cerebrospinal fluid for the detection of infectious meningitis].
abstract: Bacterial meningitis and tubercular meningitis are still neurological emergencies characterized by severe mortality and morbidity. Recent studies of meta-analysis have shown the usefulness of cerebrospinal fluid (CSF) lactate and CSF adenosine deaminase (ADA) as markers for the detection of bacterial meningitis and tubercular meningitis, respectively. CSF lactate has a high sensitivity and specificity for the diagnosis of bacterial meningitis, but the sensitivity can be reduced by antibiotic pretreatment. CSF-ADA has a moderate sensitivity but a high specificity and is reliable for the diagnosis of tubercular meningitis. These old diagnostic markers can be evaluated in resource-poor settings including small general hospitals and non-specialized hospitals for infectious diseases, and they can contribute to the quick and accurate diagnosis of infectious meningitis.
authors.affiliation: Department of Neurology, Hokkaido University Graduate School of Medicine.
authors.forename: Ken
authors.initials: K
authors.lastname: Sakushima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yabe
authors.forename: Hidenao
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000243:Adenosine Deaminase / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D006801:Humans; D019344:Lactic Acid / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000175:diagnosis*; D017410:Practice Guidelines as Topic; D012680:Sensitivity and Specificity; D014390:Tuberculosis, Meningeal / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D019344:Lactic Acid; D000243:Adenosine Deaminase