title: Ethyl 2-cyanoacrylate tissue adhesive in partial lobectomy in rats.
abstract: OBJECTIVE
  To determine the efficacy of ethyl 2-cyanoacrylate adhesive in repairing the lung parenchyma after partial lobectomy in rats, in terms of hemostasis/aerostasis, scarring, and surgical time.
  
  
  METHODS
  The study involved 30 Wistar rats, randomly divided into five groups (one control group and four study groups). In the study groups, the lung parenchyma was repaired with either cyanoacrylate adhesive or surgical suture following resection of a small or large fragment (25% or 50%, respectively) of the left caudal lung lobe.
  
  
  RESULTS
  Surgical time and hemostasis time were shorter in the two groups treated with the adhesive than in the two submitted to suture. There were no significant differences among the groups regarding specific lung compliance. Adherences and inflammatory reactions were more severe in the groups submitted to suture.
  
  
  CONCLUSIONS
  In this study, the use of cyanoacrylate adhesive helped reduce the surgical time and the intensity of inflammatory reactions, as well as preserving lung compliance. Cyanoacrylate adhesives should be considered an option for lung parenchyma repair, decreasing the risk of complications after partial lobectomy in humans.
authors.affiliation: Federal University of Paraná, Curitiba, PR, Brazil. arianiinaira@yahoo.com.br
authors.forename: Ariani Cavazzani
authors.initials: AC
authors.lastname: Szkudlarek
authors.forename: Paula
authors.initials: P
authors.lastname: Sincero
authors.forename: Renato Silva de
authors.initials: RS
authors.lastname: Sousa
authors.forename: Rosalvo Tadeu Hochmuller
authors.initials: RT
authors.lastname: Fogaça
mesh_terms: D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004812:Epidemiologic Methods; D006490:Hemostatics / Q000008:administration & dosage; D007249:Inflammation / Q000517:prevention & control; D008168:Lung / Q000187:drug effects / Q000601:surgery*; D008297:Male; D023421:Models, Animal; D011013:Pneumonectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014014:Tissue Adhesives / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003487:Cyanoacrylates; D006490:Hemostatics; D014014:Tissue Adhesives; C029054:ethyl 2-cyanoacrylate