title: [Research progress of salvianolic acid A].
abstract: Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation. Salvianolic acid A possessed multiple pharmacological activities, including antioxidants, myocardial ischemic protection, antithrombatic, neuroprotection, anti fibrosis, prevention of diabetes and complications. Recently, preliminary pharmacokinetics characteristics of salvianolic acid A were clarified. Based on the research literature and study work from author's laboratory, this review will focus on recent developments concerning the chemistry, pharmacology and pharmacokinetic of salvianolic acid A, and prospect further research.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Weiku
authors.initials: W
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiuying
authors.initials: X
authors.lastname: Yang
authors.forename: Lianhua
authors.initials: L
authors.lastname: Fang
authors.forename: Shoubao
authors.initials: S
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Shi
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Yu
authors.forename: Subo
authors.initials: S
authors.lastname: Wang
authors.forename: Haiguang
authors.initials: H
authors.lastname: Yang
authors.forename: Jialin
authors.initials: J
authors.lastname: Sun
authors.forename: Shuo
authors.initials: S
authors.lastname: Tian
authors.forename: Guanhua
authors.initials: G
authors.lastname: Du
mesh_terms: D000818:Animals; D035843:Biomedical Research; D002109:Caffeic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007773:Lactates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D007773:Lactates; C066201:salvianolic acid A