title: Family history and breast cancer hormone receptor status in a Spanish cohort.
abstract: BACKGROUND
  Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.
  
  
  METHODS
  A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.
  
  
  RESULTS
  Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ER-&PR-. Women with a family history of breast cancer were more likely to have ER-&PR- tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91-2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34-5.81).
  
  
  CONCLUSIONS
  An increased proportion of ER-&PR- breast cancer was observed among younger Spanish women with a family history of the disease.
authors.affiliation: Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America. xuejuanj@usc.edu
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jiang
authors.forename: Jose Esteban
authors.initials: JE
authors.lastname: Castelao
authors.forename: Elisabet
authors.initials: E
authors.lastname: Chavez-Uribe
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernandez Rodriguez
authors.forename: Catuxa
authors.initials: C
authors.lastname: Celeiro Muñoz
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Redondo
authors.forename: Maite
authors.initials: M
authors.lastname: Peña Fernandez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Novo Dominguez
authors.forename: Carina Doris
authors.initials: CD
authors.lastname: Pereira
authors.forename: María Elena
authors.initials: ME
authors.lastname: Martínez
authors.forename: Tomás
authors.initials: T
authors.lastname: García-Caballero
authors.forename: Máximo
authors.initials: M
authors.lastname: Fraga Rodriguez
authors.forename: José
authors.initials: J
authors.lastname: Antúnez
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Forteza-Vila
authors.forename: Manuela
authors.initials: M
authors.lastname: Gago-Dominguez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000208:ethnology / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000208:ethnology / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D015331:Cohort Studies; D004198:Disease Susceptibility; D005192:Family Health / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012307:Risk Factors; D013030:Spain
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear