title: [Advance in detection methods of microbes on historic stones--a review].
abstract: We reviewed the methods for identification of microorganisms on the surface of historic stones, including nucleic acid analysis, cell membrane analysis, secondary metabolites analysis and the traditional culture analysis. After comprehensive comparison of the advantages and disadvantages of each method, we addressed the biological protection of stone artifacts. The establishment of rapid detection of microorganisms on the historic stones is important to prevent corrosion caused by microorganisms and to protect our valuable cultural heritage.
authors.affiliation: National Key Subject of Microbiology, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China. shuilifang@mail.nanki.edu.cn
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhu
authors.forename: Jiao
authors.initials: J
authors.lastname: Pan
mesh_terms: D001419:Bacteria / Q000145:classification* / Q000302:isolation & purification*; D002623:Chemistry Techniques, Analytical / Q000379:methods; D019411:Clinical Laboratory Techniques / Q000379:methods; D003343:Corrosion; D008420:Manufactured Materials / Q000382:microbiology*