title: MKP-2: out of the DUSP-bin and back into the limelight.
abstract: The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-specificity phosphatases) which function to terminate the activity of the MAPKs (mitogen-activated protein kinases). Several members have already been demonstrated to have distinct roles in immune function, cancer, fetal development and metabolic disorders. One DUSP of renewed interest is the inducible nuclear phosphatase MKP-2, which dephosphorylates both ERK (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) in vitro. Recently, the understanding of MKP-2 function has been advanced due to the development of mouse knockout models, which has resulted in the discovery of novel roles for MKP-2 in the regulation of sepsis, infection and cell-cycle progression that are distinct from those of other DUSPs. However, many functions for MKP-2 still await to be characterized.
authors.affiliation: Division of Cell Biology, University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, 161 Cathedral Street, Glasgow G4 0RE, UK.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lawan
authors.forename: Emma
authors.initials: E
authors.lastname: Torrance
authors.forename: Sameer
authors.initials: S
authors.lastname: Al-Harthi
authors.forename: Muhannad
authors.initials: M
authors.lastname: Shweash
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Alnasser
authors.forename: Thikryat
authors.initials: T
authors.lastname: Neamatallah
authors.forename: Juliane
authors.initials: J
authors.lastname: Schroeder
authors.forename: Robin
authors.initials: R
authors.lastname: Plevin
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D003593:Cytoplasm / Q000201:enzymology; D054637:Dual-Specificity Phosphatases / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D007527:Isoenzymes; D020928:Mitogen-Activated Protein Kinases; D054639:Mitogen-Activated Protein Kinase Phosphatases; C490583:DUSP4 protein, human; D054637:Dual-Specificity Phosphatases