title: System identification of baroreflex response to mild lower body negative pressure.
abstract: The effect of mild lower body negative pressure (LBNP) on baroreflex control of arterial blood pressure (ABP) has long been thought to affect cardiopulmonary baroreflex only, although recent studies have pointed out that arterial baroreceptors may be transiently unloaded too after the rapid onset of mild LBNP. This paper presents a spectral decomposition method for the black box identification of the contribution of arterial and cardiopulmonary baroreflexes to beat-by-beat variability of ABP in response to mild LBNP levels. The significant decrease of mean and diastolic arterial pressure and of the arterial baroreflex mediated contribution to overall variability of ABP which was found, suggested that the unloading of arterial baroreceptors may be reflected by an altered dynamic response of arterial baroreflex, too. In addition, arterial baroreflex mediated modulations were found to be the main player in the modulation of beat-by-beat fluctuations of ABP, while the role of cardiopulmonary baroreflex mediated responses appeared to contribute very little.
authors.affiliation: Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 23, 20133 Milan, Italy. federico.aletti@polimi.it
authors.forename: Federico
authors.initials: F
authors.lastname: Aletti
authors.forename: Manuela
authors.initials: M
authors.lastname: Ferrario
authors.forename: Da
authors.initials: D
authors.lastname: Xu
authors.forename: Danielle K
authors.initials: DK
authors.lastname: Greaves
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Shoemaker
authors.forename: Philippe
authors.initials: P
authors.lastname: Arbeille
authors.forename: Sergio
authors.initials: S
authors.lastname: Cerutti
authors.forename: Richard L
authors.initials: RL
authors.lastname: Hughson
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Baselli
mesh_terms: D000465:Algorithms; D017704:Baroreflex; D001794:Blood Pressure; D005260:Female; D006801:Humans