title: Anthropometric measures and risk of ovarian cancer among BRCA1 and BRCA2 mutation carriers.
abstract: Studies conducted among women in the general population suggest that various anthropometric measures, including height and weight, may be associated with the risk of developing ovarian cancer. Whether such an association exists among women who carry a BRCA1 or BRCA2 mutation has not been evaluated. Thus, we investigated the association between height, weight, changes in body weight, and BMI, and the risk of developing ovarian cancer among 938 women carrying a BRCA1 or BRCA2 mutation. A matched case-control study was conducted in 469 pairs of women carrying a deleterious mutation in either BRCA1 (n = 403 pairs) or BRCA2 (n = 66 pairs). Information about height and weight at ages 18, 30, and 40 was collected from a questionnaire routinely administered to women during the course of genetic counseling. Conditional logistic regression was used to estimate the association between these body size measures and the risk of ovarian cancer. Height, weight, and BMI were not associated with the risk of ovarian cancer (P-trend ≥ 0.15). Also, there was no association between changes in body weight between ages 18-30, or ages 30-40, or ages 18-40 and the risk of ovarian cancer (P-trend ≥ 0.28). The results from this study suggest that height, weight, or weight gain do not influence the risk of ovarian cancer among carriers of a BRCA1 or BRCA2 mutation.
authors.affiliation: Women's College Research Institute, Toronto, Ontario, Canada.
authors.forename: Jacob
authors.initials: J
authors.lastname: McGee
authors.forename: Joanne
authors.initials: J
authors.lastname: Kotsopoulos
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.forename: Henry T
authors.initials: HT
authors.lastname: Lynch
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
authors.forename: Nadine
authors.initials: N
authors.lastname: Tung
authors.forename: Charmaine
authors.initials: C
authors.lastname: Kim-Sing
authors.forename: Beth
authors.initials: B
authors.lastname: Karlan
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: Peter
authors.initials: P
authors.lastname: Ainsworth
authors.forename: Parviz
authors.initials: P
authors.lastname: Ghadirian
authors.forename: Leigha
authors.initials: L
authors.lastname: Senter
authors.forename: Andrea
authors.initials: A
authors.lastname: Eisen
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006580:Genetic Carrier Screening / Q000379:methods; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult