title: Eccrine angiomatous hamartoma with sudden enlargement and pain in an adolescent girl after menarche.
abstract: Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion characterized histologically by a proliferation of eccrine glands and vascular structures-generally capillaries-in the middle and deep dermis. Sudden enlargement of EAH lesions with or without pain has been noted during puberty and pregnancy and has been attributed to hormonal stimulation. We herein describe a case of EAH that became symptomatic in an adolescent girl. A 13-year-old girl presented with pain associated with a sudden enlargement of a previously asymptomatic swelling on her right second toe. She had an 8-year history of an asymptomatic swelling on her right second toe, and the symptoms appeared approximately 1 year after menarche. Physical examination revealed swelling of the plantar surface of her right second toe. The overlying surface was erythematous with a small amount of fine scales. The biopsied tissue showed a nodular proliferation of eccrine glands intimately admixed with numerous small vessels in the deep dermis and subcutaneous fat tissue. Mucin deposition was present in the stroma surrounding the proliferating eccrine coils and ducts and in the upper dermis. A diagnosis of EAH was made. We suggest that hormonal changes during puberty may have played a role in the rapid growth and pain in the present case.
authors.affiliation: Division of Dermatology; Department of Internal Related; Kobe University Graduate School of Medicine; Kobe, Japan.
authors.forename: Ayuko
authors.initials: A
authors.lastname: Kikusawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Oka
authors.forename: Kumiko
authors.initials: K
authors.lastname: Taguchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Makoto
authors.initials: M
authors.lastname: Kunisada
authors.forename: Chikako
authors.initials: C
authors.lastname: Nishigori