title: Loss of class I MHC function alters behavior and stress reactivity.
abstract: The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunology in the past decade. Mice lacking both β-2microglobulin and transporter associated with antigen processing (β2M-/-TAP-/-) showed differences in basal behavior. In response to saline injection, β2M-/-TAP-/- mice showed a significant hypothalamic pituitary adrenal activation that was not observed in wild type mice, while lipopolysaccharide-induced cytokine expression in the hypothalamus was similar in β2M-/-TAP-/- and wild type mice. Overall, these data show that class I MHC plays an important role in behavior and stress reactivity.
authors.affiliation: Bachelor of Health Sciences Program, McMaster University, Canada.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Sankar
authors.forename: Robyn N
authors.initials: RN
authors.lastname: MacKenzie
authors.forename: Jane A
authors.initials: JA
authors.lastname: Foster
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology; D001522:Behavior, Animal; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D005805:Genes, MHC Class I / Q000235:genetics / Q000276:immunology*; D007031:Hypothalamus / Q000276:immunology / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D013312:Stress, Physiological / Q000235:genetics / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D026901:Membrane Transport Proteins; D001613:beta 2-Microglobulin