title: The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico.
abstract: Exposure to environmental tobacco smoke (ETS) during early childhood increases the risk of developing asthma. The intention of this study was to genotype a population of children from Coahuila state in Northern Mexico and to determine whether polymorphisms of the CYP1A1, GSTP1, and IL13 genes are associated with exposure to ETS and subsequently a higher risk for asthma. IL13 plays an important role in the development of allergic response, particularly those related with airway inflammation. CYP1A1 and GSTP1 are xenobiotic-metabolizing enzymes induced by repeated exposure to toxicants. Polymorphisms of these genes have been related with ETS exposure and increased risk for asthma. To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val) on asthma risk and ETS exposure, we recruited 201 unrelated children and classified them into four groups: (1) control without ETS exposure; (2) control with ETS exposure; (3) with asthma and with ETS exposure and (4) with asthma and without ETS exposure. No association among ETS exposure, asthma, and the studied polymorphisms was denoted by multivariate analysis of this population.
authors.affiliation: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, DF 07360, Mexico. rbmunoz@cinvestav.mx
authors.forename: Balam
authors.initials: B
authors.lastname: Muñoz
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Magaña
authors.forename: Israel
authors.initials: I
authors.lastname: Romero-Toledo
authors.forename: Evelyn
authors.initials: E
authors.lastname: Juárez-Pérez
authors.forename: Andrea
authors.initials: A
authors.lastname: López-Moya
authors.forename: Norberto
authors.initials: N
authors.lastname: Leyva-García
authors.forename: Celsa
authors.initials: C
authors.lastname: López-Campos
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Dávila-Borja
authors.forename: Arnulfo
authors.initials: A
authors.lastname: Albores
mesh_terms: D000367:Age Factors; D001249:Asthma / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008800:Mexico; D015999:Multivariate Analysis; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D018793:Interleukin-13; D014028:Tobacco Smoke Pollution; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi