title: Comparison of different segmentation approaches without using gold standard. Application to the estimation of the left ventricle ejection fraction from cardiac cine MRI sequences.
abstract: A statistical method is proposed to compare several estimates of a relevant clinical parameter when no gold standard is available. The method is illustrated by considering the left ventricle ejection fraction derived from cardiac magnetic resonance images and computed using seven approaches with different degrees of automation. The proposed method did not use any a priori regarding with the reliability of each method and its degree of automation. The results showed that the most accurate estimates of the ejection fraction were obtained using manual segmentations, followed by the semiautomatic methods, while the methods with the least user input yielded the least accurate ejection fraction estimates. These results were consistent with the expected performance of the estimation methods, suggesting that the proposed statistical approach might be helpful to assess the performance of estimation methods on clinical data for which no gold standard is available.
authors.affiliation: Laboratoire d’Imagerie Fonctionnelle, UPMC Inserm UMR S 678, Paris, France. frouin@imed.jussieu.fr
authors.forename: Jessica
authors.initials: J
authors.lastname: Lebenberg
authors.forename: Irène
authors.initials: I
authors.lastname: Buvat
authors.forename: Mireille
authors.initials: M
authors.lastname: Garreau
authors.forename: Christopher
authors.initials: C
authors.lastname: Casta
authors.forename: Constantin
authors.initials: C
authors.lastname: Constantinidès
authors.forename: Jean
authors.initials: J
authors.lastname: Cousty
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cochet
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Jehan-Besson
authors.forename: Christophe
authors.initials: C
authors.lastname: Tilmant
authors.forename: Muriel
authors.initials: M
authors.lastname: Lefort
authors.forename: Elodie
authors.initials: E
authors.lastname: Roullot
authors.forename: Laurent
authors.initials: L
authors.lastname: Najman
authors.forename: Laurent
authors.initials: L
authors.lastname: Sarry
authors.forename: Patrick
authors.initials: P
authors.lastname: Clarysse
authors.forename: Alain
authors.initials: A
authors.lastname: de Cesare
authors.forename: Alain
authors.initials: A
authors.lastname: Lalande
authors.forename: Frédérique
authors.initials: F
authors.lastname: Frouin
mesh_terms: D006321:Heart / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012044:Regression Analysis; D016277:Ventricular Function, Left