title: Synthesis of (-)-julocrotine and a diversity oriented Ugi-approach to analogues and probes.
abstract: An improved total synthesis of (-)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (-)-julocrotine analogues was synthesized by employing the heterocyclic precursor as an amino input in Ugi four-component reactions (Ugi-4CR) [1].
authors.affiliation: Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.
authors.forename: Ricardo A W
authors.initials: RA
authors.lastname: Neves Filho
authors.forename: Bernhard
authors.initials: B
authors.lastname: Westermann
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann