title: Synthesis of lauryl grafted sodium alginate and optimization of the reaction conditions.
abstract: Lauryl grafted sodium alginate (SA-C(12)) was prepared by the reaction between sodium alginate and dodecanol with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as a coupling agent. The structure of SA-C(12) was confirmed by FT-IR, (1)H NMR, and thermoanalysis. Meantime, the degree of substitution (DS) of SA-C(12) was determined by GC. The reaction conditions were studied systematically, which included reaction time and temperature, the molar ratio of hexuronic acid in alginate to dodecanol (N(hexuronic)/N(dodecanol)) and N(hexuronic)/N(EDC), the mass of toluenesulfonic acid. By investigating the relationship between these conditions and DS, the optimal conditions with the maximum DS were obtained.
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China. jsyang@yzu.edu.cn
authors.forename: Jisheng
authors.initials: J
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: He
mesh_terms: D000464:Alginates / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002234:Carbodiimides / Q000737:chemistry; D007851:Dodecanol / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
chemical_list: C518491:1-ethyl-3-(3-(diethylamino)propyl)carbodiimide; D000464:Alginates; D001672:Biocompatible Materials; D002234:Carbodiimides; D006603:Hexuronic Acids; D007851:Dodecanol