title: A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from Garcinia multiflora: effects on neutrophil pro-inflammatory responses.
abstract: A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC(50)  values of 7.21±1.07 and 6.01±0.37 μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.
authors.affiliation: Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Ting
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ming-Hong
authors.initials: MH
authors.lastname: Yen
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects*; D010196:Pancreatic Elastase / Q000378:metabolism; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: C571974:garcimultiflorone D; D013481:Superoxides; D010696:Phloroglucinol; D010196:Pancreatic Elastase; D000218:Adamantane