title: In situ formation of porous space maintainers in a composite tissue defect.
abstract: Reconstruction of composite defects involving bone and soft tissue presents a significant clinical challenge. In the craniofacial complex, reconstruction of the soft and hard tissues is critical for both functional and aesthetic outcomes. Constructs for space maintenance provide a template for soft tissue regeneration, priming the wound bed for a definitive repair of the bone tissue with greater success. However, materials used clinically for space maintenance are subject to poor soft tissue integration, which can result in wound dehiscence. Porous materials in space maintenance applications have been previously shown to support soft tissue integration and to allow for drug release from the implant to further prepare the wound bed for definitive repair. This study evaluated solid and low porosity (16.9% ± 4.1%) polymethylmethacrylate space maintainers fabricated intraoperatively and implanted in a composite rabbit mandibular defect model for 12 weeks. The data analyses showed no difference in the solid and porous groups both histologically, evaluating the inflammatory response at the interface and within the pores of the implants, and grossly, observing the healing of the soft tissue defect over the implant. These results demonstrate the potential of porous polymethylmethacrylate implants formed in situ for space maintenance in the craniofacial complex, which may have implications in the potential delivery of therapeutic drugs to prime the wound site for a definitive bone repair.
authors.affiliation: Department of Bioengineering, Rice University, Houston, Texas, USA.
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Spicer
authors.forename: James D
authors.initials: JD
authors.lastname: Kretlow
authors.forename: Allan M
authors.initials: AM
authors.lastname: Henslee
authors.forename: Meng
authors.initials: M
authors.lastname: Shi
authors.forename: Simon
authors.initials: S
authors.lastname: Young
authors.forename: Nagi
authors.initials: N
authors.lastname: Demian
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Wong
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.forename: F Kurtis
authors.initials: FK
authors.lastname: Kasper
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D008297:Male; D011817:Rabbits; D023822:Tissue Engineering