title: Human ROBO1 regulates interaural interaction in auditory pathways.
abstract: In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.
authors.affiliation: Brain Research Unit, OV Lounasmaa Laboratory, School of Science, Aalto University, FI-00076 AALTO, Espoo, Finland. satu.lamminmaki@aalto.fi
authors.forename: Satu
authors.initials: S
authors.lastname: Lamminmäki
authors.forename: Satu
authors.initials: S
authors.lastname: Massinen
authors.forename: Jaana
authors.initials: J
authors.lastname: Nopola-Hemmi
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
authors.forename: Riitta
authors.initials: R
authors.lastname: Hari
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000503:physiopathology*; D001306:Auditory Pathways / Q000503:physiopathology*; D004252:DNA Mutational Analysis; D004410:Dyslexia / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D004423:Ear / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000235:genetics*; D005192:Family Health; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D055815:Young Adult; D000097905:Roundabout Proteins
chemical_list: D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins