title: Portable and cost-effective pixel super-resolution on-chip microscope for telemedicine applications.
abstract: We report a field-portable lensless on-chip microscope with a lateral resolution of <1 μm and a large field-of-view of ~24 mm(2). This microscope is based on digital in-line holography and a pixel super-resolution algorithm to process multiple lensfree holograms and obtain a single high-resolution hologram. In its compact and cost-effective design, we utilize 23 light emitting diodes butt-coupled to 23 multi-mode optical fibers, and a simple optical filter, with no moving parts. Weighing only ~95 grams, we demonstrate the performance of this field-portable microscope by imaging various objects including human malaria parasites in thin blood smears.
authors.affiliation: Department of Electrical Engineering, University of California, Los Angeles 90095, USA. bishara@ucla.edu
authors.forename: Waheb
authors.initials: W
authors.lastname: Bishara
authors.forename: Uzair
authors.initials: U
authors.lastname: Sikora
authors.forename: Onur
authors.initials: O
authors.lastname: Mudanyali
authors.forename: Ting-Wei
authors.initials: TW
authors.lastname: Su
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Yaglidere
authors.forename: Shirley
authors.initials: S
authors.lastname: Luckhart
authors.forename: Aydogan
authors.initials: A
authors.lastname: Ozcan
mesh_terms: D000465:Algorithms; D000818:Animals; D003362:Cost-Benefit Analysis; D004867:Equipment Design; D006696:Holography; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007909:Lenses; D008288:Malaria / Q000469:parasitology; D008853:Microscopy / Q000191:economics* / Q000295:instrumentation*; D010271:Parasites / Q000166:cytology; D017216:Telemedicine / Q000191:economics* / Q000295:instrumentation*