title: Inhibition of neointimal proliferation after bare metal stent implantation with low-pressure drug delivery using a paclitaxel-coated balloon in porcine coronary arteries.
abstract: A variety of mechanical and laser-based methods remove or shift atherosclerotic plaques and reopen the artery to its original lumen. Subsequent treatment with drug-coated balloons (DCB) may smooth the vessel wall but does not require high-pressure inflation. We investigated the efficacy of paclitaxel-coated balloons inflated with only 2 atm after bare metal stent implantation in coronary arteries of 24 pigs. Angiography and histomorphometry was performed on day 28. DCB inflated with 2 atm caused similar reduction of late lumen loss (LLL) as high-pressure inflation with 12 atm (0.89 ± 0.58 vs. 0.72 ± 0.39 mm, p = 0.34). Both DCB treatments significantly (p < 0.01) reduced LLL versus uncoated balloons (1.50 ± 0.51 mm). Treatment with low-pressure DCB resulted in less maximal intimal thickness (0.45 ± 0.15 vs. 0.67 ± 0.25 mm) and neointimal area (2.93 ± 0.73 vs. 3.82 ± 1.27 mm(2)) than treatment with uncoated balloons (p < 0.05). In conclusion, low-pressure treatment with DCB was similarly effective as high-pressure treatment justifying clinical trials in vessels which will benefit from inhibition of neointimal proliferation but may not tolerate high inflation pressure.
authors.forename: Bodo
authors.initials: B
authors.lastname: Cremers
authors.forename: Bettina
authors.initials: B
authors.lastname: Kelsch
authors.forename: Yvonne P
authors.initials: YP
authors.lastname: Clever
authors.forename: Neil
authors.initials: N
authors.lastname: Hattangadi
authors.forename: Dirk
authors.initials: D
authors.lastname: Mahnkopf
authors.forename: Ulrich
authors.initials: U
authors.lastname: Speck
authors.forename: Matthias
authors.initials: M
authors.lastname: Taupitz
authors.forename: Bruno
authors.initials: B
authors.lastname: Scheller
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000188:drug therapy; D003331:Coronary Vessels / Q000187:drug effects* / Q000601:surgery; D054855:Drug-Eluting Stents; D008297:Male; D058426:Neointima / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage*; D011312:Pressure; D015607:Stents / Q000009:adverse effects*; D013552:Swine
chemical_list: D017239:Paclitaxel