title: Improvement of tumor localization of photosensitizers for photodynamic therapy and its application for tumor diagnosis.
abstract: Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan. sogura@bio.titech.ac.jp
authors.forename: Shun-Ichiro
authors.initials: S
authors.lastname: Ogura
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hagiya
authors.forename: Kenji
authors.initials: K
authors.lastname: Tabata
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kamachi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Okura
mesh_terms: D006801:Humans; D008665:Metalloporphyrins / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D009928:Organ Specificity; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry*
chemical_list: D008665:Metalloporphyrins; D017319:Photosensitizing Agents