title: Pulmonary veno-occlusive disease following reduced-intensity allogeneic bone marrow transplantation for acute myeloid leukemia.
abstract: We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.
authors.affiliation: Kanazawa University Graduate School of Medical Science, Japan. hosokawa@med3.m.kanazawa-u.ac.jp
authors.forename: Kohei
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishitsuji
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Takami
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008297:Male; D011668:Pulmonary Veno-Occlusive Disease / Q000175:diagnosis* / Q000209:etiology; D019172:Transplantation Conditioning / Q000009:adverse effects*; D055815:Young Adult