title: Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice.
abstract: PC-1505 is a C34 peptide derived from the heptad repeat 2 region of HIV-1 gp41 conjugated to human serum albumin for sustained in vivo activity. One single preexposure dose of PC-1505 reduced viral RNA in HIV-1-infected SCID-hu Thy/Liv mice by 3.3 log₁₀ and protected T cells from virus-mediated depletion. In contrast, a single preexposure dose of Truvada reduced viral RNA by only 0.8 log₁₀ and was substantially less effective in preventing T cell depletion.
authors.affiliation: Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA. cheryl.stoddart@ucsf.edu
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Stoddart
authors.forename: Geneviève
authors.initials: G
authors.lastname: Nault
authors.forename: Sofiya A
authors.initials: SA
authors.lastname: Galkina
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bousquet-Gagnon
authors.forename: Dominique
authors.initials: D
authors.lastname: Bridon
authors.forename: Omar
authors.initials: O
authors.lastname: Quraishi
mesh_terms: D000818:Animals; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D000069480:Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; D005805:Genes, MHC Class I / Q000235:genetics; D016655:HIV Core Protein p24 / Q000097:blood; D023581:HIV Fusion Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology; D051379:Mice; D016513:Mice, SCID; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D012367:RNA, Viral / Q000097:blood; D060168:Thymocytes / Q000187:drug effects / Q000378:metabolism / Q000821:virology
chemical_list: D004338:Drug Combinations; D000069480:Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; D016655:HIV Core Protein p24; D023581:HIV Fusion Inhibitors; D009943:Organophosphorus Compounds; C534488:PC 1505; D010455:Peptides; D012367:RNA, Viral; D003841:Deoxycytidine