title: Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities.
abstract: A series of 6,8-diiodocoumarin-3-N-carboxamides (4-11) were prepared. Treatment of ethyl 6,8-diiodocoumarin-3-carboxylate (1) with ethyl cyanoacetate/NH(4)OAc gave ethyl 2-(3-carbamoyl-6,8-diiodocoumarin-4-yl)-2-cyanoacetate (12) and 2-amino-4-hydroxy-7,9-diiodocoumarino[3,4-c]pyridine-1-carbonitrile (13), and treatment with acetone in the presence of NH(4)OAc or methylamine gave the ethyl 4-oxo-2,6-methano-2-methyl-3,4,5,6-tetrahydro-8,10-diiodobenzo[2,1-g]-2H-1,3-oxazocine-5-carboxylate derivatives 14a,b. All compounds were evaluated for their antimicrobial activity and the compounds 12-14a,b exhibited a pronounced effect on all tested microorganisms.
authors.affiliation: Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
authors.forename: Hany M
authors.initials: HM
authors.lastname: Mohamed
authors.forename: Ashraf H F Abd
authors.initials: AH
authors.lastname: El-Wahab
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: El-Agrody
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Bedair
authors.forename: Fathy A
authors.initials: FA
authors.lastname: Eid
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Khafagy
authors.forename: Kamal A
authors.initials: KA
authors.lastname: Abd-El-Rehem