title: Multifocal infantile hepatic hemangiomas--imaging strategy and response to treatment after propranolol and steroids including review of the literature.
abstract: Infantile hepatic hemangioma is the most common benign liver tumor during infancy. Prompt diagnosis and timely institution of therapy are of utmost importance. Magnetic resonance imaging (MRI) plays a key role in the correct diagnosis and monitoring of treatment. We report on a 15-week-old girl with multifocal infantile hemangiomas of the liver and high output congestive heart failure. Diagnosis was confirmed by MRI. Subsequent treatment with propranolol and steroids showed dramatic regression of the lesions within 24 weeks. We present the characteristic MRI findings and discuss treatment options together with a comprehensive review of the relevant literature.                         Conclusion Propranolol appears highly efficacious in the management of infantile hepatic hemangioma; dedicated MRI is essential in confirming the diagnosis and monitoring of treatment.
authors.affiliation: Division of Pediatric Radiology, Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 North Wolfe Street, Nelson Basement, B-172, Baltimore, MD 21287-0842, USA.
authors.forename: Thangamadhan
authors.initials: T
authors.lastname: Bosemani
authors.forename: Katherine B
authors.initials: KB
authors.lastname: Puttgen
authors.forename: Thierry A G M
authors.initials: TA
authors.lastname: Huisman
authors.forename: Aylin
authors.initials: A
authors.lastname: Tekes
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology; D006391:Hemangioma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D011239:Prednisolone / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D005938:Glucocorticoids; D011239:Prednisolone; D011433:Propranolol