title: How the blood pool properties at onset affect the temporal behavior of simulated bruises.
abstract: The influence of initial blood pool properties on the temporal behavior of bruises is currently unknown. We addressed this important issue by utilizing three typical classes of bruises in our three-layered finite compartment model. We simulated the effects of their initial shapes, regularity of boundaries and initial blood concentration distributions (gaussian vs. homogeneous) on the hemoglobin and bilirubin areas in the dermal top layer. Age determination of bruises with gaussian hemoglobin concentration was also addressed. We found that the initial blood pool properties strongly affect bruise behavior. We determined the age of a 200-h simulated bruise with gaussian hemoglobin concentration with 3 h uncertainty. In conclusion, bruise behavior depends non-intuitively on the initial blood pool properties; hence, a model that includes shape, area and concentration distribution at onset is indispensable. Future age determination, including inhomogeneous hemoglobin distributions, will likely be based on the presented method for gaussian distributions.
authors.affiliation: Biomedical Engineering and Physics, Academic Medical Centre, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. barbarastam@gmail.com
authors.forename: Barbara
authors.initials: B
authors.lastname: Stam
authors.forename: Martin J C van
authors.initials: MJ
authors.lastname: Gemert
authors.forename: Ton G van
authors.initials: TG
authors.lastname: Leeuwen
authors.forename: Maurice C G
authors.initials: MC
authors.lastname: Aalders
mesh_terms: D001663:Bilirubin / Q000097:blood; D003288:Contusions / Q000097:blood* / Q000473:pathology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D001663:Bilirubin