title: Stereoselective synthesis of fully protected (2S,4S,6S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD).
abstract: The stereocontrolled synthesis of fully protected (2S,4S,6S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
mesh_terms: D000478:Alkylation; D003652:Decanoic Acids / Q000737:chemistry*; D018698:Glutamic Acid / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003652:Decanoic Acids; D018698:Glutamic Acid; C031071:decanoic acid