title: Lymphoplasmacytic lymphoma causing light chain cast nephropathy.
abstract: Plasma cell dyscrasias are frequently associated with kidney disease through the production of monoclonal immunoglobulin but with a diverse set of pathologic renal patterns. While almost all patients with a renal biopsy showing a cast nephropathy have myeloma, kidney involvement associated with pathological immunoglobulin light chains and lymphoma is rare. To our knowledge, this is the first report of a cast nephropathy associated with lymphoplasmacytic lymphoma. We emphasize the relation between light chain deposition and renal dysfunction in this disease with production of light chains. A therapeutic approach that decreases light chain production appears to be warranted in these patients.
authors.affiliation: Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona, Spain.
authors.forename: Nuria S
authors.initials: NS
authors.lastname: Pérez
authors.forename: Adriana
authors.initials: A
authors.lastname: Garcia-Herrera
authors.forename: Laura
authors.initials: L
authors.lastname: Rosiñol
authors.forename: Lily
authors.initials: L
authors.lastname: Palos
authors.forename: Evelyn
authors.initials: E
authors.lastname: Santiago
authors.forename: Gerard
authors.initials: G
authors.lastname: Espinosa
authors.forename: Manel
authors.initials: M
authors.lastname: Solé
authors.forename: Josep M
authors.initials: JM
authors.lastname: Campistol
authors.forename: Luis F
authors.initials: LF
authors.lastname: Quintana
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D011379:Prognosis; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D007147:Immunoglobulin Light Chains