title: [Correlation between podoplanin-positive lymphatic microvessel density and CT characteristics of non-small cell lung cancer].
abstract: OBJECTIVE
  It has been proven that ymphatic microvessel density (LMVD) was closely correlated with the lymphatic metastasis of non-small cell lung cancer (NSCLC). The aim of the present study is to explore the relationship between podoplanin-LMVD and multi-slice spiral computed tomography (MSCT) characteristics of NSCLC.
  
  
  METHODS
  MSCT scanning was performed on 34 cases of NSCLC (squamous carcinoma, 15 cases; adenocarcinoma, 15 cases; and adenosquamous carcinoma, 4 cases) prior to operation. Clinical pathology results, including lymph node metastasis, were obtained. CT characteristics, such as shape of the edge, internal structure, and adjacent structures, were described. LMVD in the central and peripheral areas examined respectively using SP immunohistochemical technique were analyzed.
  
  
  RESULTS
  Lymph node metastasis was found to be associated with LMVD in the peripheral areas. LMVD in the peripheral areas of the resected lesions, the MSCT findings of which included spinous process, pleural indentation, and carcinomatous lymphangitis, was higher than that of the lesions without these MSCT characteristics (P<0.05).
  
  
  CONCLUSIONS
  MSCT findings of spinous process, pleural indentation, or carcinomatous lymphangitis of NSCLC may suggest a higher level of tumor lymphangiogenesis with a higher risk of lymph node metastasis.
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Zeng
authors.initials: Z
authors.lastname: Xiong
authors.forename: Jinkang
authors.initials: J
authors.lastname: Liu
authors.forename: Shengxi
authors.initials: S
authors.lastname: Chen
authors.forename: Moling
authors.initials: M
authors.lastname: Zhou
authors.forename: Yangtengyu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D055806:Microvessels / Q000000981:diagnostic imaging / Q000378:metabolism*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D000098853:Podoplanin
chemical_list: D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin