title: An open label non-comparative case series on the efficacy of an enzyme alginogel.
abstract: OBJECTIVE
  To evaluate the efficacy of an enzyme alginogel in outpatients with chronic or acute wounds left to heal by secondary intention.
  
  
  METHODS
  This evaluation was a single-centre, single-arm, case series involving 23 patients with wounds of diverse aetiologies treated with the enzyme alginogel (Flaminal; Flen Pharma). The product was applied in accordance with the manufacturer's instructions and wounds were covered with secondary dressings. Treatment was based on a scheduled protocol and patients were assessed at days 14, 30 and 60.
  
  
  RESULTS
  Median baseline dimensions for the wounds were surface area 2.6cm2 and volume 2.8cm3. Median wound duration before application of the enzyme alginogel was 292 days, with 16 chronic wounds (78%). Three wounds were clinically infected at baseline; two were negative by day 14 and the third by day 30. After 2 months, wound surface area and volume had decreased, as could be expected. Two adverse events were reported: an allergic reaction in the skin surrounding the wound and transient maceration.
  
  
  CONCLUSIONS
  The enzyme alginogel facilitated healing in chronic and acute wounds of diverse aetiologies. Additional research is warranted to confirm the clinical utility of the dressings in the management of chronic or acute wounds left to heal by secondary intention.
authors.affiliation: Emergency Department, Army Military Hospital, Rome, Italy. vulnoterapia@libero.it
authors.forename: C M
authors.initials: CM
authors.lastname: Durante
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000464:Alginates / Q000627:therapeutic use*; D001458:Bandages; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D014946:Wound Infection / Q000628:therapy; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*
chemical_list: D000464:Alginates; D001672:Biocompatible Materials