title: Overexpression of Yin Yang 1 in the pathogenesis of human hematopoietic malignancies.
abstract: The transcription factor Yin Yang (YY) 1 has been reported to be overexpressed in several tumor types and plays a role in both the progression of the disease as well as the maintenance of tumor cell resistance to cell death by cytotoxic drugs. YY1 also has been reported to be a prognostic factor for several cancers and was proposed to be a therapeutic target. The expression, function, and role of YY1 in the pathogenesis of hematologic malignancies are summarized briefly herein. Data are represented for B non-Hodgkin lymphoma, AIDS-related lymphoma, multiple myeloma, and children's acute lymphocytic leukemia.
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, USA. bbonavida@mednet.ucla.edu
authors.forename: B
authors.initials: B
authors.lastname: Bonavida
authors.forename: S
authors.initials: S
authors.lastname: Huerta-Yepez
authors.forename: S
authors.initials: S
authors.lastname: Baritaki
authors.forename: M
authors.initials: M
authors.lastname: Vega
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Berenson
mesh_terms: D019337:Hematologic Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D050986:YY1 Transcription Factor / Q000235:genetics / Q000502:physiology*
chemical_list: D050986:YY1 Transcription Factor; C494698:YY1 protein, human