title: A cycle-averaged model of hypoplastic left heart syndrome (HLHS).
abstract: This paper is concerned with computational modeling of a severe congenital defect called Hypoplastic left heart syndrome (HLHS) that is the most common cardiac malformation with the highest likelihood of deaths in newborns. A lumped parameter model of the HLHS circulation has been developed to study the hemodynamic variables in the various sections of the cardio-pulmonary circulation system. We applied a short-term, cycle-averaging operation to the differential equations of the HLHS model to obtain the cycle-averaged model. Study has been carried out to analyze the variation of blood flow rate in different parts due to parameter changes. Results show that the developed model, could bring a good insight into understanding of the HLHS disease.
authors.affiliation: department of Mechanical Engineering, Villanova University, Villanova, PA 19085, USA. ali.jalali@ villanova.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Jalali
authors.forename: C
authors.initials: C
authors.lastname: Nataraj
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D003326:Coronary Circulation; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011652:Pulmonary Circulation