title: Expression of IL-17, IL-23 and their receptors in minor salivary glands of patients with primary Sjögren's syndrome.
abstract: The main purpose of this study was to determine the expression of interleukins-17/-23 (ILs-17/-23) and receptors of interleukins-17/-23 (IL-17R, IL-23R) in minor salivary glands (MSGs) of patients with primary Sjögren's syndrome (pSS). Expression of IL-17, IL-23 and receptors of IL-17/-23 was analyzed in MSGs from 25 patients with pSS, 25 patients with probable preclinical pSS, and 25 patients with nonautoimmune sicca syndrome by immunohistochemistry. Comparison of the expression of IL-17, IL-23 and receptors of IL-17, IL-23 in MSG of patients with pSS with probable preclinical pSS, and with nonautoimmune sicca syndrome showed significant differences between three groups. However, the expression of IL-17, IL-23 and receptors of IL-17/-23 in MSG was comparable in pSS and probable preclinical pSS patients. We did not find correlation between the expression of IL-17 and IL-23 and of IL-17R and IL-23R in patients with pSS. These results demonstrate an involvement of IL-17/-23 system in the early pSS pathogenesis.
authors.affiliation: Department of Experimental and Clinical Medicine, State Research Institute Center for Innovative Medicine, Zygimantu Street 9, 01102 Vilnius, Lithuania. diana.mieliauskaite@ekmi.vu.lt
authors.forename: Diana
authors.initials: D
authors.lastname: Mieliauskaite
authors.forename: Irena
authors.initials: I
authors.lastname: Dumalakiene
authors.forename: Rita
authors.initials: R
authors.lastname: Rugiene
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Mackiewicz
mesh_terms: D000368:Aged; D015551:Autoimmunity; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D053759:Interleukin-23 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism*; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D012470:Salivary Glands, Minor / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000503:physiopathology
chemical_list: C515500:IL23R protein, human; D020381:Interleukin-17; D053759:Interleukin-23; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17