title: [Expression of BRMS1 gene protein in nasal and paranasal sinus carcinomas].
abstract: OBJECTIVE
  To investigate the role and clinical significance of the expression of BRMS1 gene in development and progression of nasal and paranasal sinus carcinomas.
  
  
  METHODS
  The expression of BRMS1 protein was detected by immunohistochemistry method in the 53 nasal and paranasal sinus carcinomas and 24 nasal polyp tissues and 10 normal mucosa. The expression of BRMS1 was analyzed in nasal and paranasal sinus carcinomas with different clinicopathological parameters.
  
  
  RESULTS
  The expression of BRMS1 in normal tissues (90.0%) and nasal polyp tissues (79.2%) was statistically significantly higher than that in nasal and paranasal sinus carcinomas (39.6%) (P < 0.01). There was a positive correlation between BRMS1 expression and TNM staging and lymph node metastasis; but not associated with pathological grade.
  
  
  CONCLUSIONS
  The loss of BRMS1 expression may be involved in the development and progression of nasal and paranasal sinus carcinomas.
authors.affiliation: Department of Otorhinolaryngology, the Second Affiliated Hospital, Qiqihar Medical College, Qiqihar, 161000, China. wangyun0452@yahoo.com.cn
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Lianhua
authors.initials: L
authors.lastname: Cong
authors.forename: Jiewu
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins
chemical_list: C410024:BRMS1 protein, human; D009363:Neoplasm Proteins; D012097:Repressor Proteins