title: [Multiple environmental risk for cancer in population of industrial town].
abstract: The investigation was undertaken in the town of Novodvinsk to assess multiple environmental population health risks from exposures to carcinogens by inhalation, oral, and dermal routes. Local exposure factors were studied in a longitudinal study by interviewing 1963 subjects according to a questionnaire. The levels of 11 carcinogens were estimated in 4 environmental media: ambient air; drinking water soil, and foodstuffs. The risk assessment model comprised three exposure routes: inhalation, oral, and dermal. Lifetime average daily doses and factors of the carcinogenic potential were used for risk assessment. Total cancer risk (TCR) across all the exposure routes was 1.4x10@-3. The contribution of oral, inhalation, and dermal routes to TCR was 94.8% (1.4x10@-3), 4.8% (6.8x10@-5), and 0.4% (5.4x10@-6), respectively. The leading environmental media for carcinogens are foodstuffs, whose contribution to the oral route was 81.3% (1.1x10@-3), and drinking water whose contribution was 18.7% (2.5x10@-4). The major contaminants contributing to cancer risk were arsenic (1. 1x10@-3), nickel (2.5x10@-4), and chloroform (3. 7x10@-5).
authors.forename: T N
authors.initials: TN
authors.lastname: Ungurianu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis* / Q000633:toxicity*; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D007221:Industry; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014505:Urban Population / Q000706:statistics & numerical data; D014507:Urbanization; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants