title: HLA-E polymorphisms in hematopoietic stem cell transplantation.
abstract: Human leukocyte antigen (HLA)-E is an inhibitory ligand of natural killer cells and γ/δ T-cells. Differential expression of HLA-E alleles on the cell surface has been reported to influence outcome of hematopoietic stem cell transplantation (HSCT). We performed HLA-E genotyping in 116 HSCT patients and their HLA-matched unrelated donors. The impact of HLA-E genotypes on patient's overall survival (OS), disease free survival (DFS), cumulative incidences for relapse, transplant-related mortality (TRM) and acute graft vs host disease (aGvHD) was assessed. Neither univariate nor multivariate analysis showed any influence of HLA-E polymorphisms on the investigated endpoints of HSCT in our cohort. We could not confirm any of the previous observations in our cohort and consider it unlikely that HLA-E polymorphisms affect outcome of HSCT.
authors.affiliation: Department of Transplantation Immunology, Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden-Wuerttemberg - Hessia, Ulm, Germany. d.fuerst@blutpspende.de
authors.forename: D
authors.initials: D
authors.lastname: Fürst
authors.forename: J
authors.initials: J
authors.lastname: Bindja
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.forename: W
authors.initials: W
authors.lastname: Herr
authors.forename: R
authors.initials: R
authors.lastname: Schwerdtfeger
authors.forename: C H
authors.initials: CH
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Recker
authors.forename: H
authors.initials: H
authors.lastname: Schrezenmeier
authors.forename: J
authors.initials: J
authors.lastname: Mytilineos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D016896:Treatment Outcome; D000097625:HLA-E Antigens
chemical_list: D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens