title: A mild and efficient direct α-amination of β-dicarbonyl compounds using iodosobenzene and p-toluenesulfonamide catalyzed by perchlorate zinc hexahydrate.
abstract: A direct α-amination of β-dicarbonyl compounds has been achieved by using iodosobenzene (PhIO) as an oxidant and p-toluenesulfonamide (TsNH(2)) as an aminating reagent in the presence of a catalytic amount of perchlorate zinc hexahydrate. The present amination reaction proceeds quickly at rt (<30 min needed for most tested substrates) to provide the corresponding α-N-tosylamido β-dicarbonyl compounds in high to excellent yields.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.forename: Xue-Sen
authors.initials: XS
authors.lastname: Hou
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang