title: Fascin-1 expression in canine cutaneous and oral melanocytic tumours.
abstract: Fascin-1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin-1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin-1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin-1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin-1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin-1 may represent a new strategy for the treatment of canine melanoma.
authors.affiliation: United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Akao
authors.forename: K
authors.initials: K
authors.lastname: Maruo
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D008545:Melanoma / Q000145:classification / Q000378:metabolism / Q000662:veterinary*; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism / Q000662:veterinary*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000378:metabolism / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D008840:Microfilament Proteins