title: Japanese traditional miso soup attenuates salt-induced hypertension and its organ damage in Dahl salt-sensitive rats.
abstract: OBJECTIVE
  We investigated the effects of long-term miso soup drinking on salt-induced hypertension in Dahl salt-sensitive (Dahl S) rats.
  
  
  METHODS
  Dahl S rats were divided into four groups that consumed 1) water, 2) a 0.9% NaCl solution, 3) a 1.3% sodium NaCl solution, or 4) miso soup containing 1.3% NaCl. They were followed for 8 wk. Systolic blood pressure and hypertensive organ damage were determined.
  
  
  RESULTS
  Systolic blood pressure increased in an age- and dose-dependent manner in Dahl S rats drinking salt solutions. The systolic blood pressure increase was significantly less in the Dahl S rats that drank miso soup, although the ultimate cumulative salt loading was greater than that in the Dahl S rats given the 1.3% NaCl solution. This blood pressure decrease was associated with a morphologic attenuation of glomerular sclerosis in the kidney and collagen infiltration in the heart. Urinary protein excretions were less in the miso group than in the rats given the 1.3% NaCl solution. The fractional excretion of sodium was increased and that of potassium was decreased in Dahl S rats given the 1.3% NaCl solution, and these effects were reversed in rats given miso soup toward the values of the control.
  
  
  CONCLUSIONS
  We found that long-term miso soup drinking attenuates the blood pressure increase in salt-induced hypertension with organ damage. This may be caused by a possible retardation of sodium absorption in the gastrointestinal tract or by the direct effects of nutrients in the miso soup from soybeans. The decrease was associated with decreases in cardiovascular and renal damage.
authors.affiliation: Department of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, Tokyo, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Natsuko
authors.initials: N
authors.lastname: Toda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tamura
authors.forename: Shouko
authors.initials: S
authors.lastname: Terakado
authors.forename: Mai
authors.initials: M
authors.lastname: Ueno
authors.forename: Kie
authors.initials: K
authors.lastname: Otsuka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numabe
authors.forename: Yukari
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uehara
mesh_terms: D000367:Age Factors; D000818:Animals; D001794:Blood Pressure; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced / Q000178:diet therapy* / Q000652:urine; D007678:Kidney Glomerulus / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D028321:Plant Preparations / Q000627:therapeutic use; D011188:Potassium / Q000652:urine; D011507:Proteinuria / Q000178:diet therapy; D051381:Rats; D020303:Rats, Inbred Dahl; D012964:Sodium / Q000008:administration & dosage / Q000009:adverse effects / Q000652:urine; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D045730:Soy Foods; D013025:Glycine max; D013995:Time
chemical_list: D028321:Plant Preparations; D017673:Sodium Chloride, Dietary; D003094:Collagen; D012964:Sodium; D011188:Potassium