title: Abnormal segregation of alleles and haplotypes at the polymorphic site of the PRNP gene within promoter and intron 1 regions in Polish Holstein-Friesian cattle.
abstract: Allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP gene was analyzed in Polish Holstein-Friesian cattle. More 23del/del homozygotes and fewer 23ins/ins homozygotes than expected were observed in the offspring of ♂ 23ins/del × ♀ 23ins/del parents. In the offspring of ♂ 23ins/del × ♀ 23del/del parents and ♂ 23del/del × ♀ 23ins/del parents, a trend toward more 23del/del animals and fewer 23ins/del animals than expected was noted. At the 12indel polymorphic site, the only trend found was one toward fewer 12ins/ins genotypes and more 12ins/del and 12del/del genotypes than expected in the offspring of ♂ 12ins/del × ♀ 12ins/del parents. An analysis of haplotype segregation revealed more 23del-12del/23del-12del diplotypes and fewer 23ins-12ins/23ins-12ins diplotypes at the significance threshold than expected in the offspring of ♂ 23ins-12ins/23del-12del × ♀ 23ins-12ins/23del-12del parents.
authors.affiliation: Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, M. Oczapowskiego 5, 10-957 Olsztyn, Poland. janusz.strychalski@uwm.edu.pl
authors.forename: Janusz
authors.initials: J
authors.lastname: Strychalski
authors.forename: Urszula
authors.initials: U
authors.lastname: Czarnik
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Zabolewicz
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D040582:Inheritance Patterns / Q000235:genetics; D007438:Introns / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011328:Prions / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D011328:Prions