title: Effect of temperature changes on the performance of ionic strength biosensors based on hydrogels and pressure sensors.
abstract: Stimuli responsive hydrogels show a strong ability to change in volume with changes in selected environmental properties. This tendency of these hydrogels to change in volume is captured as pressure-change in confined cavities of pressure sensors. An array of pressure sensors on a single chip may carry hydrogels sensitive to multiple, selected metabolic markers and continuously monitor multiple vital parameters simultaneously. Currently, such sensors are capable of continuously monitoring pH, ionic strength, glucose levels and temperature in the sensor environment. In this paper, we report the effect of temperature changes on the performance of ionic strength sensor. A formulation of hydrogel that renders it sensitive to changes in ionic strength was UV polymerized in situ in piezoresistive pressure sensors with different membrane sizes. The sensor sensitivity, response time and stability are investigated as a function of temperature in vitro. The effect of temperature on these sensor characteristics is discussed.
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA. nder.avula@utah.e
authors.forename: Mahender
authors.initials: M
authors.lastname: Avula
authors.forename: Nora
authors.initials: N
authors.lastname: Busche
authors.forename: Seung Hei
authors.initials: SH
authors.lastname: Cho
authors.forename: Prashant
authors.initials: P
authors.lastname: Tathireddy
authors.forename: Loren W
authors.initials: LW
authors.lastname: Rieth
authors.forename: Jules J
authors.initials: JJ
authors.lastname: Magda
authors.forename: Florian
authors.initials: F
authors.lastname: Solzbacher
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020100:Hydrogels / Q000032:analysis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000032:analysis*; D008365:Manometry / Q000295:instrumentation*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013696:Temperature
chemical_list: D020100:Hydrogels; D007477:Ions