title: Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior.
abstract: Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes.
authors.affiliation: School of Engineering and Applied Science, Harvard University, Cambridge, MA, United States. jshim@seas.harvard.edu
authors.forename: Jongmin
authors.initials: J
authors.lastname: Shim
authors.forename: Anna
authors.initials: A
authors.lastname: Grosberg
authors.forename: Janna C
authors.initials: JC
authors.lastname: Nawroth
authors.forename: Kevin Kit
authors.initials: KK
authors.lastname: Parker
authors.forename: Katia
authors.initials: K
authors.lastname: Bertoldi
mesh_terms: D000818:Animals; D055119:Elastic Modulus / Q000502:physiology; D004548:Elasticity / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D051381:Rats; D023822:Tissue Engineering / Q000379:methods