title: Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats.
abstract: To investigate the reproductive toxicity and teratogenic potential of quinocetone, a growth promoting agent, Wistar rats were fed different diets containing 0, 50, 300 and 1800 mg/kg quinocetone or 300 mg/kg olaquindox. Groups of 15 males and 30 females (F(0)) were fed through a 10-week prebreed period as well as during mating, gestation, parturition and lactation. At weaning, 12 males and 24 females of F(1) generation weanlings per group were selected randomly as parents for F(2) generation. Selected F(1) weanlings were exposed to the same diet and treatment as their parents. At the highest quinocetone group, body weights in F(0) and F(1) rats, fetal body weight on day 21 after birth and number of viable fetuses in F(0) and F(1) generation significantly decreased. In teratogenicity study, groups of 12 males and 24 females were fed with the same diets through a 12-week prebreed period and matting periods. Pregnant rats were subjected to cesarean section on GD 20 for teratogenic examination. At the highest quinocetone group, body weights and feed efficiency, fetal body lengths, tail lengths, litter weights and number of viable fetuses significantly decreased. The NOAEL for reproduction/development of quinocetone for rats was estimated to be 300 mg/kg diet.
authors.affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU)/MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yu-Lian
authors.initials: YL
authors.lastname: Wang
authors.forename: Awais
authors.initials: A
authors.lastname: Ihsan
authors.forename: Meng-Hong
authors.initials: MH
authors.lastname: Dai
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Huang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Chen
authors.forename: Yan-Fei
authors.initials: YF
authors.lastname: Tao
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Peng
authors.forename: Zhen-Li
authors.initials: ZL
authors.lastname: Liu
authors.forename: Zong-Hui
authors.initials: ZH
authors.lastname: Yuan
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D011810:Quinoxalines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D011810:Quinoxalines; D013723:Teratogens; C502851:quinocetone