title: Mild reaction conditions for the terminal deuteration of alkynes.
abstract: Routinely employed syntheses of terminally deuterated alkynes often utilize strong bases (i.e., LDA, n-BuLi, or Grignard reagents) or low (i.e., -78 °C) or elevated (i.e., 56 °C) reaction temperatures; furthermore many of these procedures afford average yields and in some cases less than optimum deuterium incorporation. Herein we report the application of alternative extremely mild reaction conditions that readily afford quantitative yields of terminally deuterated alkynes in a matter of minutes with exceptional isotope incorporation at ambient temperature.
authors.affiliation: School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, UK, NR4 7TJ. s.bew@uea.ac.uk
authors.forename: Sean P
authors.initials: SP
authors.lastname: Bew
authors.forename: Glyn D
authors.initials: GD
authors.lastname: Hiatt-Gipson
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Lovell
authors.forename: Christophe
authors.initials: C
authors.lastname: Poullain
mesh_terms: D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001388:Aziridines / Q000138:chemical synthesis; D002241:Carbohydrates / Q000737:chemistry; D002437:Cefazolin / Q000138:chemical synthesis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000596:Amino Acids; D000900:Anti-Bacterial Agents; D001388:Aziridines; D002241:Carbohydrates; C033132:aziridine; D002437:Cefazolin