title: Liver-specific microRNA-122: Biogenesis and function.
abstract: microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.
authors.affiliation: Centre for Biomolecular Sciences; University of Nottingham; University Park; Nottingham, UK. Catherine.jopling@nottingham.ac.uk
authors.forename: Catherine
authors.initials: C
authors.lastname: Jopling
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009928:Organ Specificity / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D014158:Transcription, Genetic
chemical_list: C531907:MIRN122 microRNA, human; D035683:MicroRNAs