title: Assessment of the antidiabetic potential of Cassia grandis using an in vivo model.
abstract: The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat, India.
authors.forename: Sandesh R
authors.initials: SR
authors.lastname: Lodha
authors.forename: Shrikant V
authors.initials: SV
authors.lastname: Joshi
authors.forename: Bhavin A
authors.initials: BA
authors.lastname: Vyas
authors.forename: Mohini C
authors.initials: MC
authors.lastname: Upadhye
authors.forename: Megha S
authors.initials: MS
authors.lastname: Kirve
authors.forename: Shweta S
authors.initials: SS
authors.lastname: Salunke
authors.forename: Sheetal K
authors.initials: SK
authors.lastname: Kadu
authors.forename: Manasi V
authors.initials: MV
authors.lastname: Rogye