title: Development of an implantable microstimulation system for chronic DBS in rodents.
abstract: High frequency deep brain stimulation (DBS) of certain basal ganglia nuclei (e.g. subthalamic nucleus, STN) has emerged as a powerful neuromodulatory approach in the treatment of late stage Parkinson's disease patients. However, the underlying mechanisms of action are not fully understood. We have therefore established an implantable DBS device for small laboratory animals (e.g. rats) that allows the reliable and safe application of continuous DBS for at least 3 weeks. We could further show that miniaturized monopolar electrodes comprising activated iridium are suitable for continuous stimulation of small brain structures like the STN without inducing severe insertion or stimulation related injuries.
authors.affiliation: Medical and Technical Laboratories, Biomedical Research Center, Charité-Universitätsmedizin Berlin, Campus Virchow, Berlin, Germany. raik.paulat@ charite.de
authors.forename: Raik
authors.initials: R
authors.lastname: Paulat
authors.forename: Wassilios
authors.initials: W
authors.lastname: Meissner
authors.forename: Rudolf
authors.initials: R
authors.lastname: Morgenstern
authors.forename: Andreas
authors.initials: A
authors.lastname: Kupsch
authors.forename: Daniel
authors.initials: D
authors.lastname: Harnack
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000662:veterinary*; D004567:Electrodes, Implanted / Q000662:veterinary*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D051381:Rats; D020531:Subthalamic Nucleus / Q000502:physiology*