title: Use of autologous skin equivalents with artificial dermal matrix (integra) in donor site coverage in radial forearm free flaps: preliminary cases.
abstract: OBJECTIVE
  The radial forearm flap is one of the most commonly used methods for intraoral reconstruction in oral carcinoma surgery. One of its disadvantages is the residual functional and unaesthetic defect in the donor site. The objective of this report is to describe preliminary cases of a novel method to cover such donor sites based on the use of autologous skin equivalents (ASEs) and an artificial dermal matrix (Integra, Prim, Barcelona, Spain).
  
  
  METHODS
  The donor sites of 2 patients were treated with the artificial dermal matrix after raising a radial forearm flap. A skin biopsy and a blood sample were taken to construct an ASE. After 3 weeks, the ASE was applied over the dermal template and left to heal. The functional and esthetic results were recorded.
  
  
  RESULTS
  Good functional and esthetic results were achieved, with correct wrist motility, although a natural skin color could not be achieved. Neither the Integra nor the ASE was rejected. Total wound coverage was achieved at 4 months, and completely normal skin was observed at 6 months.
  
  
  CONCLUSIONS
  This technique of combining an artificial dermal matrix with an ASE could be an alternative method to cover the donor sites of radial forearm flaps.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Central University Hospital of Asturias, Oviedo, Asturias, Spain. napegomaxilo@gmail.com
authors.forename: Ignacio
authors.initials: I
authors.lastname: Peña
authors.forename: Lucas
authors.initials: L
authors.lastname: de Villalaín
authors.forename: Eva
authors.initials: E
authors.lastname: García
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Junquera
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: de Vicente
mesh_terms: D018929:Cell Culture Techniques; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D004954:Esthetics; D005542:Forearm / Q000502:physiology / Q000601:surgery*; D058752:Free Tissue Flaps; D006801:Humans; D011884:Radius / Q000601:surgery; D016059:Range of Motion, Articular / Q000502:physiology; D019651:Plastic Surgery Procedures / Q000379:methods; D012038:Regeneration / Q000502:physiology; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation / Q000473:pathology; D017768:Skin, Artificial; D060053:Transplant Donor Site / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology; D014955:Wrist Joint / Q000502:physiology
chemical_list: C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen