title: Transfusion medicine problems and solutions for the pediatric hematologist/oncologist.
abstract: Blood component transfusion is an integral part of the care of children with oncologic and hematologic conditions. The complexity of transfusion medicine may however lead to challenges for pediatric hematologists/oncologists. In this review, three commonly encountered areas of transfusion medicine are explored. The approach to the investigation and management of suspected platelet refractoriness is reviewed. The unique transfusion related challenges encountered by children undergoing stem cell transplantation are also discussed. Finally, issues arising out of the care of children with hemoglobinopathies are explored, with an emphasis on the incidence of allo- and autoimmunization.
authors.affiliation: Division of Laboratory Medicine and Hematology, Children's National, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: Naomi L C
authors.initials: NL
authors.lastname: Luban
authors.forename: Eileen
authors.initials: E
authors.lastname: McBride
authors.forename: Jason C
authors.initials: JC
authors.lastname: Ford
authors.forename: Sumit
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D002648:Child; D004306:Dose-Response Relationship, Immunologic; D006405:Hematology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008495:Medical Oncology; D010372:Pediatrics; D017713:Platelet Transfusion
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies