title: Increased albuminuria in 4-year-old preterm-born children with normal height.
abstract: OBJECTIVE
  To determine risk factors for high blood pressure (BP), increased markers of glomerulosclerosis, and tubular dysfunction in 4-year-old preterm-born children.
  
  
  METHODS
  The study group was a longitudinal cohort of 119 children with BP, albuminuria, and β2 microglobulin measurements obtained during the neonatal period and at age 4 years.
  
  
  RESULTS
  Systolic BP was >95(th) percentile in 15 (12.6%) of the children at age 4 years and lower in those born small for gestational age compared with those born appropriate for gestational age. Preterm-born 4-year-olds with height <-1 SD had lower systolic and diastolic BP, and 14.4% of the 4-year-olds had albuminuria. Albuminuria was less prevalent in the 4-year-olds with height <-1 SD than in those with height ≥-1 SD (6.8% vs 19.3%; P=.04). Mean albuminuria level was 1.0±0.7 mg/mmol in 4-year-olds with height <-1 SD and 1.4±1.3 mg/mmol in those with height ≥-1 SD. In multivariate analysis, albuminuria level was increased by 0.4±0.2 mg/mmol in preterm-born children with normal height at age 4, and by 0.5±0.2 mg/mmol in females, after adjustment for gestational age, sex, neonatal morbidity, and intrauterine growth restriction. These results were unchanged after adjustment for body mass index.
  
  
  CONCLUSIONS
  Normal height at age 4 years may be associated with an increased risk for glomerulosclerosis in preterm-born children.
authors.affiliation: Neonatal Department, Nancy, France. r.vieux@maternite.chu-nancy.fr
authors.forename: Rachel
authors.initials: R
authors.lastname: Vieux
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Hascoët
authors.forename: Patricia
authors.initials: P
authors.lastname: Franck
authors.forename: F
authors.initials: F
authors.lastname: Guillemin
mesh_terms: D000419:Albuminuria / Q000453:epidemiology / Q000209:etiology* / Q000652:urine; D001827:Body Height; D015992:Body Mass Index; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D001613:beta 2-Microglobulin