title: Effects at early stage of life of elevated milk replacer feeding on growth rate, plasma IGF-I concentration and intestinal nutrient transporter expression in Holstein bull calves.
abstract: In order to evaluate the effects of an elevated amount of modified milk replacer on body weight, daily gain, starter intake, plasma endocrine parameters and expression of nutrient transporters in small intestinal epithelia, Holstein bull calves (n=24) were fed for 60days either with the usual amount of 24% crude protein (CP) and 20% fat milk (CF) replacer (C group), or with a double amount of a modified milk replacer of 28% CP and 16% CF (E group). Body weight from D20 to D60 and daily gain before D40 was greater or tended to be greater for the E group than the C group. Plasma concentrations of insulin-like growth factor-1 (IGF-I) and insulin were greater for the E group than the C group on D28 but not on D56, without changing plasma growth hormone levels. Gene expression for sodium-dependent glucose transporter 1 and fatty acid translocase (CD36) was altered in day- and intestine-dependent manners. From these findings, we conclude that an elevated intake of milk replacer given up to 40days old is sufficient to enhance body weight, which may be associated with increased plasma IGF-I concentrations, in Holstein bulls.
authors.affiliation: Mito Research Center, Meiji Feed Co., Wakamiya, Ibaraki             Department of Animal Physiology, GSAR, Tohoku University, Aoba, Sendai, Japan.
authors.forename: Takenori
authors.initials: T
authors.lastname: Orihashi
authors.forename: Takanori
authors.initials: T
authors.lastname: Mashiko
authors.forename: Kenji
authors.initials: K
authors.lastname: Sera
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Roh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Obara
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects*; D018955:CD36 Antigens / Q000378:metabolism*; D002417:Cattle / Q000254:growth & development*; D004435:Eating / Q000187:drug effects; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D007070:Immunoglobulin A / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D041941:Milk Substitutes / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D018955:CD36 Antigens; D051272:Glucose Transporter Type 1; D007070:Immunoglobulin A; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone