title: Resistin level in coronary artery disease and heart failure:  the central role of kidney function.
abstract: OBJECTIVE
  The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor.
  
  
  METHODS
  One hundred and seven outpatients with CAD were enrolled in the study and divided into three groups: CAD without left-ventricular systolic dysfunction (group 1); CAD with left-ventricular dysfunction without heart failure symptoms (group 2); CAD with overt heart failure (group 3). Plasma resistin was determined by ELISA.
  
  
  RESULTS
  Resistin progressively increased from group 1 (10.7±5.0 ng/ml) to groups 2 (11.8±5.8 ng/ml) and 3 (17.0±6.8 ng/ml), with the difference reaching statistical significance in group 3 versus groups 1 and 2 (P=0.001). A multivariable model of analysis demonstrated that the best predictor of plasma resistin level was the estimated glomerular filtration rate (P<0.001), indicating that reduction of kidney function was the main cause of the adipokine increase observed in patients with CAD and overt heart failure.
  
  
  CONCLUSIONS
  Our data confirm the rise of resistin plasma levels previously described in patients affected by chronic heart failure; however, in our study, this relationship seemed to be mediated mainly by the level of kidney function, and only partially by the severity of ventricular dysfunction.
authors.affiliation: Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, Florence, Italy. pesine@libero.it
authors.forename: Samuele
authors.initials: S
authors.lastname: Baldasseroni
authors.forename: Edoardo
authors.initials: E
authors.lastname: Mannucci
authors.forename: Claudia
authors.initials: C
authors.lastname: Di Serio
authors.forename: Francesco
authors.initials: F
authors.lastname: Orso
authors.forename: Nadia
authors.initials: N
authors.lastname: Bartoli
authors.forename: Enrico
authors.initials: E
authors.lastname: Mossello
authors.forename: Alice
authors.initials: A
authors.lastname: Foschini
authors.forename: Matteo
authors.initials: M
authors.lastname: Monami
authors.forename: Paolo
authors.initials: P
authors.lastname: Valoti
authors.forename: Stefano
authors.initials: S
authors.lastname: Fumagalli
authors.forename: Claudia
authors.initials: C
authors.lastname: Colombi
authors.forename: Silvia
authors.initials: S
authors.lastname: Pellerito
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Gensini
authors.forename: Niccolò
authors.initials: N
authors.lastname: Marchionni
authors.forename: Francesca
authors.initials: F
authors.lastname: Tarantini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011237:Predictive Value of Tests; D011379:Prognosis; D052243:Resistin / Q000097:blood*; D012189:Retrospective Studies; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D052243:Resistin