title: Human hepatitis B viral e antigen and its precursor P20 inhibit T lymphocyte proliferation.
abstract: The hepatitis B virus (HBV) Precore protein is processed through the secretory pathway directly as HBeAg or with the generation of an intermediate (P20). Precore gene has been shown to be implicated in viral persistence, but the functions of HBeAg and its precursors have not been fully elucidated. We show that the secreted proteins HBeAg and P20 interact with T cell surface and alter Kit-225 and primary T cells proliferation, a process which may facilitate the establishment of HBV persistence. Our data indicate that the N-terminal end of Precore is important for these inhibitory effects and exclude that they are dependent on the association of HBeAg and P20 with two characterized cell surface ligands, the Interleukin-1 Receptor Accessory Protein and gC1qR (present study).
authors.affiliation: Université de Versailles-Saint-Quentin-en-Yvelines, Laboratoire de Génétique et Biologie Cellulaire, EA 4589, 45 avenue des Etats-Unis, 78035 Versailles, France.
authors.forename: Maija
authors.initials: M
authors.lastname: Purvina
authors.forename: Astrid
authors.initials: A
authors.lastname: Hoste
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Rossignol
authors.forename: Cécile
authors.initials: C
authors.lastname: Lagaudrière-Gesbert
mesh_terms: D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000276:immunology; D049109:Cell Proliferation; D002478:Cells, Cultured; D006513:Hepatitis B e Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D053577:Interleukin-1 Receptor Accessory Protein / Q000276:immunology; D008213:Lymphocyte Activation; D024101:Mitochondrial Proteins / Q000276:immunology; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*
chemical_list: C087299:C1QBP protein, human; D002352:Carrier Proteins; D006513:Hepatitis B e Antigens; D053577:Interleukin-1 Receptor Accessory Protein; D024101:Mitochondrial Proteins