title: Patient specific cardiovascular risk assessment and treatment decision support based on multiscale modelling and medical guidelines.
abstract: In this work we present an enhanced medical workflow and a decision support system for atherosclerotic risk assessment and treatment, that is based both on existing medical guidelines and on patient specific multiscale data. The medical expert that uses the system is able to apply both existing medical guidelines as well as to take into account additional information for the patient by inspecting the 3D geometry of an arterial segment or the arterial tree, model the blood flow in the patient specific arterial model and predict the progression of the plaque. Moreover, the user is able to apply plaque characterization techniques in Intravascular Ultrasound images (IVUS) and Tomography Images (CT). The combination of the medical guidelines with the patient specific multiscale data provides a detailed view in the patient status for risk assessment and treatment suggestion.
authors.affiliation: Foundation for Research and Technology Hellas, Biomedical Research Institute, University of Ioannina, Ioannina GR 45110, Greece. exarchos@cc.uoi.gr
authors.forename: Themis P
authors.initials: TP
authors.lastname: Exarchos
authors.forename: Yorgos
authors.initials: Y
authors.lastname: Goletsis
authors.forename: Kostas
authors.initials: K
authors.lastname: Stefanou
authors.forename: Evaggelos
authors.initials: E
authors.lastname: Fotiou
authors.forename: Dimitrios I
authors.initials: DI
authors.lastname: Fotiadis
authors.forename: Oberdan
authors.initials: O
authors.lastname: Parodi
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003198:Computer Simulation; D020000:Decision Support Systems, Clinical / Q000592:standards*; D006801:Humans; D008955:Models, Cardiovascular; D017410:Practice Guidelines as Topic; D015995:Prevalence; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014481:United States