title: Cluster sizes in interleaved silent steady state (ISSS) imaging.
abstract: The effect of increasing the number of scans in the "cluster" of an interleaved silent steady state (ISSS) fMRI imaging scheme from 1 to 2, and then to 3 was examined by a fixed-effects analysis of an auditory short-term memory task with four subjects. Compared to a cluster size of 1, a cluster of 2 scans improved sensitivity at detecting brain activity and statistical power, while a cluster of 3 scans further improved statistical power but seemed not to improve sensitivity beyond that achieved with a cluster of 2 scans. The findings reveal that cluster size is a vital parameter for an ISSS imaging scheme.
authors.affiliation: Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Champaign, IL 61820,USA. kakrofi@illinois.edu
authors.forename: Kwaku
authors.initials: K
authors.lastname: Akrofi
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Sutton
authors.forename: Cheng
authors.initials: C
authors.lastname: Ouyang
authors.forename: Fatima T
authors.initials: FT
authors.lastname: Husain
mesh_terms: D000328:Adult; D000465:Algorithms; D001306:Auditory Pathways; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory; D008570:Memory, Short-Term; D015233:Models, Statistical; D012680:Sensitivity and Specificity; D013997:Time Factors