title: High temporal resolution dynamic contrast-enhanced MRI at 7 Tesla: a feasibility study with mouse liver model.
abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution for quantitative tracer kinetic analysis. This study illustrates the feasibility of applying a high temporal resolution (2 s) protocol for liver imaging in mice by analyzing the DCE-MRI datasets of mice liver with a dual-input two-compartment tracer kinetic model. Phantom studies were performed to validate the T(1) estimates derived by the proposed protocol before applying it in mice studies. The DCE-MRI datasets of mice liver were amendable to tracer kinetic analysis using a dual-input two-compartment model. Estimated micro-circulatory parameters were consistent with liver physiology, indicating viability of applying the technique for pre-clinical drug developments.
authors.affiliation: National Cancer Centre Singapore and Nanyang Technological University, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Hartono
authors.forename: C H
authors.initials: CH
authors.lastname: Thng
authors.forename: Q S
authors.initials: QS
authors.lastname: Ng
authors.forename: C X
authors.initials: CX
authors.lastname: Yong
authors.forename: C-T
authors.initials: CT
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Shi
authors.forename: K H
authors.initials: KH
authors.lastname: Chuang
authors.forename: T S
authors.initials: TS
authors.lastname: Koh
mesh_terms: D000818:Animals; D003287:Contrast Media; D005240:Feasibility Studies; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media