title: [MRI for brain structure and function in patients  with first-episode panic disorder].
abstract: OBJECTIVE
  To determine the brain function and structure in patinets with first-episode panic disorder (PD).
  
  
  METHODS
  All subjects (24 PD patients and 24 healthy subjects) received MRI scan and emotional counting Stroop task during the functional magnetic resonance imaging. Blood oxygenation level dependent functional magnetic resonance imaging and voxel-based morphometric technology were used to detect the gray matter volume.
  
  
  RESULTS
  Compared with the healthy controls, left thalamus, left medial frontal gyrus, left anterior cingulate gyrus, left inferior frontal gyrus, left insula (panic-related words vs. neutral words) lacked activation in PD patients, but the over-activation were found in right brain stem, right occipital lobe/lingual gyrus in PD patients. Compared with the healthy controls, the gray matter volume in the PD patients significantly decreased in the left superior temporal gyrus, right medial frontal gyrus, left medial occipital gyrus, dorsomedial nucleus of left thalamus and right anterior cingulate gyrus. There was no significantly increased gray matter volume in any brain area in PD patients.
  
  
  CONCLUSIONS
  PD patients have selective attentional bias in processing threatening information due to the depression and weakening of the frontal cingulated gyrus.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Mei
authors.initials: M
authors.lastname: Liao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D016584:Panic Disorder / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult