title: A case of monoclonal immunoglobulin G1-lambda deposition associated with membranous feature in a patient with hepatitis C viral infection.
abstract: A 63-year-old man with hepatitis C virus infection was admitted to our hospital for nephrotic syndrome. Light microscopic analysis of a percutaneous renal biopsy showed thickening of the glomerular capillary walls and spike formation. Immunofluorescence revealed granular deposition of monoclonal immunoglobulin G1-lambda and C3 complement along the glomerular basement membrane. Urinary protein excretion decreased slightly after combined treatment with steroid and an immunosuppressive agent. Monoclonal immunoglobulin deposition disease with membranous feature is rare. Additional reports of such cases are needed to elucidate the mechanisms and optimal therapy for this rare entity.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. t-yamada@nms.ac.jp
authors.forename: Takehisa
authors.initials: T
authors.lastname: Yamada
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Mii
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneko
authors.forename: Koichi
authors.initials: K
authors.lastname: Utsumi
authors.forename: Yukinari
authors.initials: Y
authors.lastname: Masuda
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D050533:Glomerular Basement Membrane / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications*; D011507:Proteinuria / Q000150:complications
chemical_list: D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains