title: Scavenger receptor class B type I: a multifunctional receptor.
abstract: The scavenger receptor class B type I (SR-B1) plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR-B1 is a high-density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR-B1 does this is unclear. Other than its role as an HDL receptor, SR-B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR-B1 has been thus far associated.
authors.affiliation: Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy. giuseppe.valacchi@unife.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Valacchi
authors.forename: Claudia
authors.initials: C
authors.lastname: Sticozzi
authors.forename: Yunsook
authors.initials: Y
authors.lastname: Lim
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pecorelli
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D018955:CD36 Antigens / Q000737:chemistry / Q000378:metabolism*; D002338:Carotenoids / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D056945:Hep G2 Cells / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D014018:Tissue Distribution / Q000502:physiology; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D018955:CD36 Antigens; D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D008070:Lipopolysaccharides; D008565:Membrane Proteins; C509768:PDZK1IP1 protein, human; D014810:Vitamin E; D002338:Carotenoids