title: Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study.
abstract: OBJECTIVE
  To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly.
  
  
  METHODS
  This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects.
  
  
  RESULTS
  328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01).
  
  
  CONCLUSIONS
  The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
authors.affiliation: Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, The Netherlands.
authors.forename: Kristian S
authors.initials: KS
authors.lastname: Frederiksen
authors.forename: Ellen
authors.initials: E
authors.lastname: Garde
authors.forename: Arnold
authors.initials: A
authors.lastname: Skimminge
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Elisabeth C W
authors.initials: EC
authors.lastname: van Straaten
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Baezner
authors.forename: Ana
authors.initials: A
authors.lastname: Verdelho
authors.forename: José M
authors.initials: JM
authors.lastname: Ferro
authors.forename: Timo
authors.initials: T
authors.lastname: Erkinjuntti
authors.forename: Hanna
authors.initials: H
authors.lastname: Jokinen
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
authors.forename: Anna M
authors.initials: AM
authors.lastname: Basile
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pantoni
authors.forename: Domenico
authors.initials: D
authors.lastname: Inzitari
authors.forename: Gunhild
authors.initials: G
authors.lastname: Waldemar
mesh_terms: D000368:Aged; D001284:Atrophy; D003072:Cognition Disorders / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003704:Dementia / Q000473:pathology / Q000523:psychology; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049292:Leukoaraiosis / Q000473:pathology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000473:pathology*; D009483:Neuropsychological Tests; D012044:Regression Analysis; D013702:Temporal Lobe / Q000473:pathology