title: Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants.
abstract: A carbapenemase-resistant Klebsiella pneumoniae strain, clone ST258 producing KPC-3, was fully characterized. The entire plasmid content was investigated, thereby identifying plasmids of the IncFII(k) (two of them similar to pKPQIL and pKPN3, respectively), IncX, and ColE types, carrying a formidable set of resistance genes against toxic compounds, metals, and antimicrobial drugs and a novel iron(III) uptake system.
authors.affiliation: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: García-Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Villa
authors.forename: Claudio
authors.initials: C
authors.lastname: Carta
authors.forename: Carolina
authors.initials: C
authors.lastname: Venditti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Giordano
authors.forename: Mario
authors.initials: M
authors.lastname: Venditti
authors.forename: Carlo
authors.initials: C
authors.lastname: Mancini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007501:Iron / Q000378:metabolism; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D008670:Metals / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D018272:Porins / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008670:Metals; C119261:OmpK35 porin, Klebsiella pneumoniae; C092233:OmpK36 protein, Klebsiella pneumoniae; D018272:Porins; D007501:Iron; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae