title: Common variation in genes related to immune response and risk of childhood leukemia.
abstract: An abnormal immune response to common infection(s) may be a plausible etiological mechanism in childhood leukemia. We investigated whether 931 tagging single nucleotide polymorphisms (SNPs) selected in gene regions related to immune response are associated with childhood leukemia susceptibility in a hospital-based case-control study (63 cases and 148 controls) conducted among Korean children. The AT or TT genotype of rs7939734 in Fas-associated protein with death domain (FADD) was associated with increased risk of childhood leukemia compared with the AA genotype (odds ratio [OR] = 2.26, 95% confidence interval [95% CI] = 1.20-4.25, p(trend) = 0.0007, min p = 0.002, false discovery rate [FDR] p = 0.17). The CG or GG genotype of rs2301696 in TRPM5 was associated with decreased risk of childhood leukemia compared with the CC genotype (OR = 0.30, 95% CI = 0.14-0.63, p(trend) = 0.002, min p = 0.004, FDR p = 0.17). Our findings suggest that genetic polymorphisms in immune response genes might play a role in childhood leukemia development with limited biologic evidence.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Han
authors.forename: Hong Hoe
authors.initials: HH
authors.lastname: Koo
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Kyoung-Mu
authors.initials: KM
authors.lastname: Lee
authors.forename: Ae Kyung
authors.initials: AK
authors.lastname: Park
authors.forename: Sue K
authors.initials: SK
authors.lastname: Park
authors.forename: Hyuna
authors.initials: H
authors.lastname: Sung
authors.forename: Hyo Seop
authors.initials: HS
authors.lastname: Ahn
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Seo
authors.forename: Yoon-Ok
authors.initials: YO
authors.lastname: Ahn
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D053200:Fas-Associated Death Domain Protein / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007109:Immunity / Q000235:genetics; D007223:Infant; D007231:Infant, Newborn; D007723:Korea; D007938:Leukemia / Q000235:genetics* / Q000276:immunology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D050053:TRPM Cation Channels / Q000235:genetics* / Q000276:immunology
chemical_list: C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D050053:TRPM Cation Channels; C404409:TRPM5 protein, human