title: Plasma metabonomics as a novel diagnostic approach for major depressive disorder.
abstract: Major depressive disorder (MDD) is a socially detrimental psychiatric disorder, contributing to increased healthcare expenditures and suicide rates. However, no empirical laboratory-based tests are available to support the diagnosis of MDD. In this study, a NMR-based plasma metabonomic method for the diagnosis of MDD was tested. Proton nuclear magnetic resonance ((1)H NMR) spectra of plasma sampled from first-episode drug-naı̈ve depressed patients (n = 58) and healthy controls (n = 42) were recorded and analyzed by orthogonal partial least-squares discriminant analysis (OPLS-DA). The OPLS-DA score plots of the spectra demonstrated that the depressed patient group was significantly distinguishable from the healthy control group. Moreover, the method accurately diagnosed blinded samples (n = 26) in an independent replication cohort with a sensitivity and specificity of 92.8% and 83.3%, respectively. Taken together, NMR-based plasma metabonomics may offer an accurate empirical laboratory-based method applicable to the diagnosis of MDD.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zheng
authors.forename: Hong C
authors.initials: HC
authors.lastname: Gao
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Wei H
authors.initials: WH
authors.lastname: Shao
authors.forename: Mei L
authors.initials: ML
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
authors.forename: De Y
authors.initials: DY
authors.lastname: Yang
authors.forename: Song H
authors.initials: SH
authors.lastname: Fan
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Fang
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
mesh_terms: D000085:Acetates / Q000097:blood; D000328:Adult; D000596:Amino Acids / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003401:Creatine / Q000097:blood; D003404:Creatinine / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007294:Inositol / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D055432:Metabolomics; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D000085:Acetates; D000596:Amino Acids; D015415:Biomarkers; D008074:Lipoproteins; D007294:Inositol; D003404:Creatinine; D003401:Creatine