title: Alumina nanoparticles alter rhythmic activities of local interneurons in the antennal lobe of Drosophila.
abstract: The special physical and chemical properties of nanomaterials open up new capabilities and functions. However, concerns have been raised about the risks produced by nanoparticles, their potential to cause undesirable effects, such as contamination of the environment and other adverse effects. In this study, we used Drosophila as a model organism to explore the effects of nano-alumina on the central nervous system. We focused on the rhythmic activities in the antennal lobe of Drosophila using patch clamps to record the electrophysiological activities. We found that 15 min after application of alumina nanoparticles, the average frequencies of spontaneous activities were significantly decreased compared with control groups (0.65 ± 0.13 Hz, 0.34 ± 0.07 Hz, *p < 0.05). These results indicated that nano-alumina might have adverse effects on the central nervous system in Drosophila.
authors.affiliation: Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
authors.forename: Naya
authors.initials: N
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Jiaoyao
authors.initials: J
authors.lastname: Lei
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Zou
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Ran
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Shuo
authors.initials: S
authors.lastname: Luan
authors.forename: Huaiyu
authors.initials: H
authors.lastname: Gu
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000537:Aluminum Oxide / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004330:Drosophila / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007395:Interneurons / Q000187:drug effects* / Q000378:metabolism; D053768:Metal Nanoparticles / Q000633:toxicity*; D018613:Microscopy, Confocal; D018408:Patch-Clamp Techniques; D010507:Periodicity; D011679:Pupa; D013997:Time Factors
chemical_list: D000537:Aluminum Oxide