title: Pulse arrival time is not an adequate surrogate for pulse transit time in terms of tracking diastolic pressure.
abstract: We compared pulse arrival time (PAT) and pulse transit time (PTT) in terms of their ability to track diastolic pressure (DP). We performed the comparison using high fidelity, invasive arterial waveforms recorded from six dogs during multiple interventions. On average, DP ranged from 40 to 106 mmHg and therefore varied widely. PAT and PTT were able to predict DP with average root-mean-squared-errors of 9.8 ± 5.8 mmHg and 5.7 ± 2.0 mmHg (p = 0.02). Thus, even though PAT is simpler to measure, we can only recommend using PTT for tracking DP.
authors.affiliation: Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. zhanggu2@msu.edu
authors.forename: Guanqun
authors.initials: G
authors.lastname: Zhang
authors.forename: Da
authors.initials: D
authors.lastname: Xu
authors.forename: N Bari
authors.initials: NB
authors.lastname: Olivier
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Mukkamala
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods*; D002318:Cardiovascular Diseases / Q000473:pathology; D002320:Cardiovascular Physiological Phenomena; D003971:Diastole; D004285:Dogs; D004566:Electrodes; D005263:Femoral Artery / Q000473:pathology; D006339:Heart Rate; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D008991:Monitoring, Physiologic; D011312:Pressure; D011674:Pulse; D013997:Time Factors