title: [Biological active substances of plant origin. Flavanones: dietary sources, biovailability, the influence on xenobiotic metabolizing enzymes].
abstract: This review summarizes data concerning distribution, as well as the main food sources and daily consumption of flavanones, a relatively small group of flavonoids exhibiting wide range of biological activities, which are mainly specific for citrus fruits. The questions on their bioavailability and metabolism are discussed. The results of the in vitro and in vivo studies on the effects of flavanones on the activity of I and II phase drug metabolizing enzymes are shown.
authors.forename: V A
authors.initials: VA
authors.lastname: Tutel'ian
authors.forename: N V
authors.initials: NV
authors.lastname: Lashneva
mesh_terms: D000818:Animals; D001682:Biological Availability; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D019587:Dietary Supplements; D044950:Flavanones / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008658:Inactivation, Metabolic; D010945:Plants, Edible; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D044950:Flavanones; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System