title: Nocistatin and nociceptin modulate c-Fos expression in the mice thalamus.
abstract: Nocistatin and nociceptin/orphanin FQ (N/OFQ) are two neuropeptides which may have opposite effects in several biological functions but their neuro-anatomical sites of interaction are not fully clear. We investigated interaction between the effect of intracerebroventricular (i.c.v.) injection of nocistatin and N/OFQ, on c-Fos expression in the mouse thalamus, using c-Fos immunohistochemistry. We found that co-injection of nocistatin with N/OFQ significantly modulates c-Fos expression in the thalamus. The present study strongly suggests that "Nocistatin-Nociceptin" interaction system in the thalamus may be the promising neuromodulatory sites in the investigation of unlocking their possible therapeutic circuit in nociception, memory and anxiety.
authors.affiliation: Universiti Teknologi MARA (UiTM), Level 19, Tower 2, Science & Technology Complex, 40450, Shah Alam, Selangor, Malaysia. kaziahsanjamil@gmail.com
authors.forename: Jamil Ahsan
authors.initials: JA
authors.lastname: Kazi
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D016762:Genes, fos / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007276:Injections, Intraventricular; D051379:Mice; D018847:Opioid Peptides / Q000008:administration & dosage* / Q000502:physiology; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism*; D000097629:Nociceptin
chemical_list: D018847:Opioid Peptides; D000097629:Nociceptin; C111148:nocistatin