title: Mitochondrial DNA haplogroups and incidence of lipodystrophy in HIV-infected patients on long-term antiretroviral therapy.
abstract: We investigated the rates of lipodystrophy events, according to mitochondrial DNA haplogroup, in 187 patients starting combination antiretroviral therapy and following it. Incidence rates of lipoatrophy and fat accumulation were 8.2 and 4.8 per 100 person-years of follow-up, respectively. In multivariable models, patients with haplogroup K were at higher risk of any lipodystrophy [adjusted relative risk (aRR) 4.02, P = 0.0009], lipoatrophy (competing-risk aRR 2.42, P = 0.09; cause-specific aRR 2.99, P = 0.031), and fat accumulation (competing-risk aRR, 2.63, P = 0.11; cause-specific aRR 5.27, P = 0.019) than those with haplogroup H. Mitochondrial haplogroups may explain part of the genetic predisposition to lipodystrophy during combination antiretroviral therapy.
authors.affiliation: Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. deluca.andrea@fastwebnet.it
authors.forename: Andrea
authors.initials: A
authors.lastname: De Luca
authors.forename: Milena
authors.initials: M
authors.lastname: Nasi
authors.forename: Simona
authors.initials: S
authors.lastname: Di Giambenedetto
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cozzi-Lepri
authors.forename: Marcello
authors.initials: M
authors.lastname: Pinti
authors.forename: Angela
authors.initials: A
authors.lastname: Marzocchetti
authors.forename: Cristina
authors.initials: C
authors.lastname: Mussini
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fabbiani
authors.forename: Laura
authors.initials: L
authors.lastname: Bracciale
authors.forename: Roberto
authors.initials: R
authors.lastname: Cauda
authors.forename: Andrea
authors.initials: A
authors.lastname: Cossarizza
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015497:HIV-1; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents; D004272:DNA, Mitochondrial