title: Correlation of serum magnesium with dyslipidemia in patients on maintenance hemodialysis.
abstract: This study was performed to determine the correlation between serum magnesium (Mg) and dyslipidemia in patients on maintenance hemodialysis (MHD). This hospital-based cross-sectional observational study was conducted at the Department of Nephro-Urology, Liaquat University Hospital, Hyderabad, Pakistan, from April 2008 to June 2008. Fifty patients with end-stage kidney disease on MHD treatment (33 males and 17 females) were studied. The mean duration on HD was 7.58 ± 2.05 years, with frequency being two to three sessions/week, and each session lasted for four hours. After obtaining informed written consent, the general information of each patient was recorded on a proforma. After overnight fasting, blood samples was drawn from the arterio-venous fistula for lipid profile, lipoprotein, serum Mg, serum creatinine, blood urea, serum calcium and serum phosphorus. Dyslipidemia was defined as presence of total cholesterol (TC), triglyceride (TG) or low-density lipoprotein (LDL) levels more then 95 th percentile for age and gender or high-density lipoprotein (HDL) levels less then 35 mg/dL. Descriptive and inferential statistical analyses were performed using SPSS version 16.0. The mean age of the study patients was 45.68 ± 13.97 years. There was a significant positive correlation between serum Mg and serum lipoprotein-a (LP-a) (r = 0.40, P < 0.007), serum HDL (r = 0.31, P < 0.01) and serum TG (r = 0.35, P < 0.005). There was no significant correlation between serum Mg and serum LDL-c and serum TC. The serum TG and LP-a levels were significantly increased while HDL-c was significantly lower in MHD patients. The serum TC, LDL-c and very low-density lipoprotein-c were not significantly elevated. We conclude that patients with chronic kidney disease undergoing MHD show positive correlation between serum Mg and serum HDL, LP-a and TG. The abnormalities of lipid metabolism, such as hyper-triglyceridemia, elevated LP-a and low HDL-c, could contribute to atherosclerosis and cardiovascular disease in these patients.
authors.affiliation: Department of Nephro-Urology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Pakistan. rafiq_87@hotmail.com
authors.forename: Muhammad Rafique
authors.initials: MR
authors.lastname: Ansari
authors.forename: Narinder
authors.initials: N
authors.lastname: Maheshwari
authors.forename: Muzaffar A
authors.initials: MA
authors.lastname: Shaikh
authors.forename: Muhammad Shahzad
authors.initials: MS
authors.lastname: Laghari
authors.forename: Kumar
authors.initials: K
authors.lastname: Lal
authors.forename: Kamran
authors.initials: K
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D006435:Renal Dialysis; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008055:Lipids; D017270:Lipoprotein(a); D008075:Lipoproteins, HDL; D014280:Triglycerides; D008274:Magnesium