title: A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats.
abstract: Previous studies have examined the therapeutic effect of endothelial progenitor cells (EPCs) during the chronic phase of cerebral infarction in rats; however, few studies have investigated the effects of EPCs during the acute phase of infarction. In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity (Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsurushima
authors.forename: Aiki
authors.initials: A
authors.lastname: Marushima
authors.forename: Masumi
authors.initials: M
authors.lastname: Nagano
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Kensuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohneda
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000096:biosynthesis*; D000818:Animals; D020520:Brain Infarction / Q000473:pathology / Q000601:surgery; D002545:Brain Ischemia / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D061307:Human Umbilical Vein Endothelial Cells / Q000201:enzymology* / Q000637:transplantation*; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000201:enzymology*; D016896:Treatment Outcome
chemical_list: D000444:Aldehyde Dehydrogenase