title: Snoring effects on the baroreflex: an animal model.
abstract: Baroreflex sensitivity (BRS) is reduced in humans during snoring, however the mechanisms are unknown. We used an anaesthetised rabbit induced snoring (IS) model, to test: (1) whether IS was associated with reduced BRS; and (2) if snoring related vibration transmission to peri-carotid tissues influenced BRS levels. BRS was quantified using the spontaneous sequence technique. During IS, BRS fell by 40%, without any associated change in blood pressure (BP) but accompanied by an increase in heart rate (HR). Direct application of a snore frequency and intensity matched vibratory stimulus to the peri-carotid tissues of non-snoring tracheostomised rabbits had no effect on BRS, HR or BP. In conclusion, IS induced depression of BRS is likely mediated via a HR driven change in BRS operating point that is unrelated to snoring-related vibration transmission to carotid baroreceptors. The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.
authors.affiliation: Ludwig Engel Centre for Respiratory Research, Sydney, NSW, Australia. jyotishna.narayan@sydney.edu.au
authors.forename: Jyotishna
authors.initials: J
authors.lastname: Narayan
authors.forename: Jason
authors.initials: J
authors.lastname: Amatoury
authors.forename: Jin-Gun
authors.initials: JG
authors.lastname: Cho
authors.forename: Manisha
authors.initials: M
authors.lastname: Verma
authors.forename: Kristina
authors.initials: K
authors.lastname: Kairaitis
authors.forename: John
authors.initials: J
authors.lastname: Wheatley
authors.forename: Terence
authors.initials: T
authors.lastname: Amis
mesh_terms: D000704:Analysis of Variance; D000758:Anesthesia; D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology; D004195:Disease Models, Animal; D004562:Electrocardiography; D004735:Energy Transfer; D006339:Heart Rate / Q000502:physiology; D008297:Male; D011312:Pressure; D011817:Rabbits; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D012913:Snoring / Q000503:physiopathology*; D013990:Tidal Volume / Q000502:physiology; D014139:Tracheostomy; D014732:Vibration