title: Fabrication of chitosan single-component microcapsules with a micrometer-thick and layered wall structure by stepwise core-mediated precipitation.
abstract: Incubation of CaCO(3)  microparticles in chitosan (CS) solution at pH 5.2 and following with ethylenediaminetetraacetic acid disodium salt (EDTA) treatment resulted in CS single-component microcapsules with an ultra-thick wall structure. Repeating the incubation caused stepwise increase of wall thickness and finally resulted in CS microcapsules with a layered structure. This unique method is mediated by precipitation of CS on the CaCO(3)  particles as a result of pH increase caused by the partial dissolution of CaCO(3) . The obtained CS capsules are stable at neutral pH.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Han
authors.forename: Weijun
authors.initials: W
authors.lastname: Tong
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D011232:Chemical Precipitation; D048271:Chitosan / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning
chemical_list: D002214:Capsules; D048271:Chitosan; D004492:Edetic Acid; D002119:Calcium Carbonate