title: Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women.
abstract: OBJECTIVE
  To study the risk for obstructive sleep apnea (OSA) in a group of nonobese and obese polycystic ovary syndrome (PCOS) and control women.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Academic tertiary care medical center.
  
  
  METHODS
  Forty-four women with PCOS and 34 control women.
  
  
  METHODS
  All of the women completed the Berlin questionnaire for assessment of OSA risk.
  
  
  METHODS
  All of the women underwent fasting determination of androgens, glucose, and insulin.
  
  
  RESULTS
  Women with PCOS were more obese compared with control women. However, there were no differences in BMI once subjects were divided into nonobese (PCOS: n = 17; control: n = 26) and obese (PCOS: n = 27; control: n = 8) groups. Women with PCOS had higher prevalence of high-risk OSA compared with control women (47% vs. 15%). However, none of the nonobese PCOS and control women screened positively for high-risk OSA. Among the obese group, the risk did not differ between groups (77% vs. 63%).
  
  
  CONCLUSIONS
  Our findings indicate that even though the risk for OSA in PCOS is high, it is related to the high prevalence of severe obesity. The risk for OSA among nonobese women with PCOS is very low. However, our findings are limited by lack of polysomnographic confirmation of OSA.
authors.affiliation: Sleep Disorders Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60612, USA.
authors.forename: Babak
authors.initials: B
authors.lastname: Mokhlesi
authors.forename: Bert
authors.initials: B
authors.lastname: Scoccia
authors.forename: Theodore
authors.initials: T
authors.lastname: Mazzone
authors.forename: Susan
authors.initials: S
authors.lastname: Sam
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D002641:Chicago / Q000453:epidemiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D011446:Prospective Studies; D012098:Reproduction; D018570:Risk Assessment; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone