title: Towards real-time metabolic profiling of a biopsy specimen during a surgical operation by 1H high resolution magic angle spinning nuclear magnetic resonance: a case report.
abstract: BACKGROUND
  Providing information on cancerous tissue samples during a surgical operation can help surgeons delineate the limits of a tumoral invasion more reliably. Here, we describe the use of metabolic profiling of a colon biopsy specimen by high resolution magic angle spinning nuclear magnetic resonance spectroscopy to evaluate tumoral invasion during a simulated surgical operation.
  
  
  METHODS
  Biopsy specimens (n = 9) originating from the excised right colon of a 66-year-old Caucasian women with an adenocarcinoma were automatically analyzed using a previously built statistical model.
  
  
  CONCLUSIONS
  Metabolic profiling results were in full agreement with those of a histopathological analysis. The time-response of the technique is sufficiently fast for it to be used effectively during a real operation (17 min/sample). Metabolic profiling has the potential to become a method to rapidly characterize cancerous biopsies in the operation theater.
authors.affiliation: Service de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, 1 Avenue Molière, 67098 Strasbourg, France. izzie.jacques.namer@chru-strasbourg.fr.
authors.forename: Martial
authors.initials: M
authors.lastname: Piotto
authors.forename: François-Marie
authors.initials: FM
authors.lastname: Moussallieh
authors.forename: Agnès
authors.initials: A
authors.lastname: Neuville
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bellocq
authors.forename: Karim
authors.initials: K
authors.lastname: Elbayed
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer