title: Mayer-Rokitansky-Küster-Hauser syndrome: a review of 245 consecutive cases managed by a multidisciplinary approach with vaginal dilators.
abstract: OBJECTIVE
  To understand the efficacy of vaginal dilators in the management of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.
  
  
  METHODS
  Retrospective sequential study.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  245 women.
  
  
  METHODS
  Vaginal dilators.
  
  
  METHODS
  Functional vaginal length and sexual satisfaction.
  
  
  RESULTS
  Of the patients who completed the program, 232 (94.9%) achieved a successful vaginal length (defined as greater than 6 cm in length and maximum width throughout the vagina and especially at the apex) and sexual function. When the program was completed by all patients, 100% of patients were successful.
  
  
  CONCLUSIONS
  Vaginal dilator therapy is the treatment of first choice for creation of the vagina in MRKH syndrome, and the success rates suggest that surgery is rarely, if ever, required.
authors.affiliation: Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom. DouglasKeith.Edmonds@imperial.nhs.uk
authors.forename: D Keith
authors.initials: DK
authors.lastname: Edmonds
authors.forename: Gillian L
authors.initials: GL
authors.lastname: Rose
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Lipton
authors.forename: Julie
authors.initials: J
authors.lastname: Quek
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000503:physiopathology / Q000628:therapy*; D000015:Abnormalities, Multiple / Q000503:physiopathology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000013:Congenital Abnormalities; D004106:Dilatation / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities; D008131:London; D008875:Middle Aged; D009095:Mullerian Ducts / Q000002:abnormalities; D010348:Patient Care Team; D017060:Patient Satisfaction; D020127:Recovery of Function; D012189:Retrospective Studies; D012725:Sexual Behavior; D019170:Somites / Q000002:abnormalities; D013131:Spine / Q000002:abnormalities; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014599:Uterus / Q000002:abnormalities / Q000503:physiopathology; D014621:Vagina / Q000002:abnormalities* / Q000503:physiopathology; D055815:Young Adult