title: Waist circumference is a strong and independent determinant of the distribution of HDL subfractions in overweight patients with cardiovascular risk factors.
abstract: OBJECTIVE
  Our aim was to determine the influence of waist circumference on the repartition of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions in patients with increased waist perimeter and one or more cardiovascular risk factor.
  
  
  METHODS
  All 117 patients without lipid-lowering therapy underwent routine clinical, biological evaluation and isolation of the following lipid subfractions: HDL2b, HDL2a, HDL3a, HDL3b, HDL3c and LDL1, LDL2, LDL3, LDL4.
  
  
  RESULTS
  Mean waist circumference was 102.9 cm for women and 109.4 cm for men, and 92 patients presented with metabolic syndrome. In the highest waist circumference tertile, when compared with the lowest one, an increased HDL3c (7.7% vs. 5.7% p=0.02) and a non-significant decrease of HDL2b percentages were observed with no difference in other subfractions. In multivariate analysis, only plasma triglycerides and waist circumference remained independent predictors of HDL3c percentage.
  
  
  CONCLUSIONS
  In our population, waist circumference was a strong and independent determinant of a shift in the distribution of HDL toward denser particles.
authors.affiliation: Unité de Prévention Cardiovasculaire, Service d'Endocrinologie Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. david.rosenbaum@psl.aphp.fr
authors.forename: David
authors.initials: D
authors.lastname: Rosenbaum
authors.forename: Boris
authors.initials: B
authors.lastname: Hansel
authors.forename: Dominique
authors.initials: D
authors.lastname: Bonnefont-Rousselot
authors.forename: Randa
authors.initials: R
authors.lastname: Bittar
authors.forename: Xavier
authors.initials: X
authors.lastname: Girerd
authors.forename: Philippe
authors.initials: P
authors.lastname: Giral
authors.forename: Eric
authors.initials: E
authors.lastname: Bruckert
mesh_terms: D050154:Adiposity; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D050177:Overweight / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D010297:Paris / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL