title: Mitochondrial electron transport chain deficiency, cardiomyopathy, and long-term cardiac transplant outcome.
abstract: Organ transplantation in multisystemic mitochondrial cytopathies is usually not performed because of perceived untoward complications. We report three patients with demonstrated oxidative phosphorylation defects and dilated cardiomyopathy who underwent cardiac transplant. All three patients tolerated immunosuppression medications and have had an excellent long-term outcome. Our results suggest that with proper patient selection in this population, cardiac transplantation is feasible and can have good outcomes.
authors.affiliation: Division of Pediatric Neurology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.
authors.forename: Alana S
authors.initials: AS
authors.lastname: Golden
authors.forename: Yuk M
authors.initials: YM
authors.lastname: Law
authors.forename: Hillary
authors.initials: H
authors.lastname: Shurtleff
authors.forename: Molly
authors.initials: M
authors.lastname: Warner
authors.forename: Russell P
authors.initials: RP
authors.lastname: Saneto
mesh_terms: D009202:Cardiomyopathies / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004579:Electron Transport; D005260:Female; D016027:Heart Transplantation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000628:therapy*; D018482:Muscle, Skeletal / Q000473:pathology; D017063:Outcome Assessment, Health Care; D010085:Oxidative Phosphorylation; D012189:Retrospective Studies; D013053:Spectrophotometry / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents