title: Behavioral training and predisposed coping strategies interact to influence resilience in male Long-Evans rats: implications for depression.
abstract: Effective coping strategies and adaptive behavioral training build resilience against stress-induced pathology. Both predisposed and acquired coping strategies were investigated in rats to determine their impact on stress responsiveness and emotional resilience. Male Long-Evans rats were assigned to one of the three coping groups: passive, active, or variable copers. Rats were then randomly assigned to either an effort-based reward (EBR) contingent training group or a non-contingent training group. Following EBR training, rats were tested in appetitive and stressful challenge tasks. Physiological responses included changes in fecal corticosterone and dehydroepiandrosterone (DHEA) metabolites as well as neuropeptide Y (NPY)-immunoreactivity in the hippocampus and amygdala. Regardless of a rat's predisposed coping strategy, EBR rats persisted longer than non-contingent rats in the appetitive problem-solving task. Furthermore, training and coping styles interacted to yield the seemingly most adaptive DHEA/corticosterone ratios in the EBR-trained variable copers. Regardless of training group, variable copers exhibited increased NPY-immunoreactivity in the CA1 region.
authors.affiliation: Psychology Department, Marshall University , Huntington, WV 25755, USA.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bardi
authors.forename: Alexandra P
authors.initials: AP
authors.lastname: Rhone
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Franssen
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Hampton
authors.forename: Eleanor A
authors.initials: EA
authors.lastname: Shea
authors.forename: Molly M
authors.initials: MM
authors.lastname: Hyer
authors.forename: Jordan
authors.initials: J
authors.lastname: Huber
authors.forename: Kelly G
authors.initials: KG
authors.lastname: Lambert
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D003345:Corticosterone / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism; D003863:Depression / Q000523:psychology*; D006728:Hormones / Q000097:blood; D007150:Immunohistochemistry; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D055500:Resilience, Psychological; D012201:Reward; D013315:Stress, Psychological / Q000097:blood; D013550:Swimming / Q000523:psychology
chemical_list: D006728:Hormones; D009478:Neuropeptide Y; D003687:Dehydroepiandrosterone; D003345:Corticosterone