title: Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome.
abstract: OBJECTIVE
  To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.
  
  
  RESULTS
  Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.
  
  
  CONCLUSIONS
  A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Kaiser Permanente Oakland Medical Center, Oakland, CA 94612, USA.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: S L
authors.initials: SL
authors.lastname: Feigenbaum
authors.forename: Y
authors.initials: Y
authors.lastname: Crites
authors.forename: G J
authors.initials: GJ
authors.lastname: Escobar
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Ferrara
authors.forename: J C
authors.initials: JC
authors.lastname: Lo
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult