title: Determinants of ochratoxin A exposure--a one year follow-up study of urine levels.
abstract: Dietary exposure to the ochratoxin A (OTA) occurring in Portugal is characterized by a high frequency of contamination of the consumed foodstuffs, although at low levels. The exposure bears significance for the total food consumed, and not for a particular one. Biomonitoring studies are thus fundamental in simplifying the evaluation of exposure, with no need to examine the entire range of consumed foodstuffs. Biomonitoring studies further allow the identification of host factors as predictors of OTA exposure in epidemiologic studies, the results of which are merited for targeting intervention strategies by public health authorities and advising official regulatory decisions. Using a longitudinal approach, this study examined factors related to OTA exposure in the adult population over a one-year period. Anthropometric measures, season of the year and region were the selected factors correlated with OTA exposure biomarker. Urine samples from 95 inhabitants from six Portuguese main geographical areas were assayed through spectrofluorimetric detection. Exposure to OTA proved to markedly increase in winter, and gender differences were observed only in summer, which might be related to different dietary patterns not only between seasons, but also between genders. The same rationale may also serve the observed statistically significant differences between some regions. No other strong association upon the remaining determinants under testing was observed. These observations reinforce the need for OTA exposure evaluation, possibly specifically targeting the staple foods or dietary habits that sustain potential predictors or determinants of exposure.
authors.affiliation: Group of Health Surveillance, Center of Pharmaceutical Studies, University of Coimbra, Health Sciences Campus, 3000-548 Coimbra, Portugal. sofiacanceladuarte@gmail.com
authors.forename: S C
authors.initials: SC
authors.lastname: Duarte
authors.forename: M R
authors.initials: MR
authors.lastname: Alves
authors.forename: A
authors.initials: A
authors.lastname: Pena
authors.forename: C M
authors.initials: CM
authors.lastname: Lino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009793:Ochratoxins / Q000652:urine*; D011174:Portugal; D012621:Seasons
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A