title: Extent of lymph node resection does not increase perioperative morbidity and mortality after surgery for stage I lung cancer in the elderly.
abstract: OBJECTIVE
  Pathologic evaluation of > 10 lymph nodes (LNs) is considered necessary for accurate lung cancer staging. However, physicians have concerns about increased risk in perioperative mortality (POM) and morbidity with more extensive LN sampling, particularly in the elderly. In this study, we compared the outcomes in elderly patients with stage I non-small cell lung cancer (NSCLC) undergoing extensive (> 10 nodes) and limited (≤ 10 nodes) LN resections.
  
  
  METHODS
  Using data from the Surveillance, Epidemiology and End Results registry linked to Medicare records, we identified 4975 patients ≥ 65 years of age with stage I NSCLC who underwent a lobectomy between 1992 and 2002. Risk of perioperative morbidity and POM after the evaluation of ≤ 10 vs. >10 LNs was compared among patients after adjusting for propensity scores.
  
  
  RESULTS
  Multiple regression analysis showed similar POM between the two groups (OR, 1,01; 95% CI, 0,71-1,44). Other postoperative complications were similar across groups except for thromboembolic events, which were more common among patients undergoing resection of > 10 LNs (OR, 1,72; 95% CI, 1,12-2,63).
  
  
  CONCLUSIONS
  These data suggest that evaluation of > 10 LNs, which allows for more accurate staging, appears to be safe in the elderly patients undergoing lobectomy for stage I NSCLC without compromising postoperative recovery.
authors.affiliation: Division of Thoracic Surgery, The Mount Sinai Medical Center, New York, NY 10029, USA. mark.shapiro@mountsinai.org
authors.forename: M
authors.initials: M
authors.lastname: Shapiro
authors.forename: G
authors.initials: G
authors.lastname: Mhango
authors.forename: M
authors.initials: M
authors.lastname: Kates
authors.forename: T S
authors.initials: TS
authors.lastname: Weiser
authors.forename: C
authors.initials: C
authors.lastname: Chin
authors.forename: S J
authors.initials: SJ
authors.lastname: Swanson
authors.forename: J P
authors.initials: JP
authors.lastname: Wisnivesky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008197:Lymph Node Excision / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008297:Male; D006278:Medicare; D009017:Morbidity; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D059035:Perioperative Period; D011013:Pneumonectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D018426:SEER Program; D016019:Survival Analysis; D014481:United States