title: Identification of CTX-M β-lactamases among Escherichia coli from the community in New York City.
abstract: We have identified CTX-M group 1 β-lactamases in 87% of community-acquired Escherichia coli isolates that produce extended-spectrum β-lactamases, with the majority harboring CTX-M-15 and representing the ST131 clonal group. Seventy percent of CTX-M-bearing isolates were from urine specimens; a large proportion was nonsusceptible to levofloxacin, trimethoprim/sulfamethoxazole, and β-lactam antimicrobials. Many patients were relatively youthful (41% ≤65 years old; youngest, age 32). Patients with symptomatic bacteriuria received drugs to which the organisms were susceptible, and most had favorable outcomes. Timely recognition of such isolates could help physicians choose more appropriate antibacterial therapy.
authors.affiliation: Infectious Disease Section, New York Hospital Queens, Flushing, NY 11355, USA.
authors.forename: Hemavarna
authors.initials: H
authors.lastname: Tiruvury
authors.forename: James R
authors.initials: JR
authors.lastname: Johnson
authors.forename: Noriel
authors.initials: N
authors.lastname: Mariano
authors.forename: Louise
authors.initials: L
authors.lastname: Grenner
authors.forename: Rita
authors.initials: R
authors.lastname: Colon-Urban
authors.forename: Mohamed
authors.initials: M
authors.lastname: Erritouni
authors.forename: Wehbeh
authors.initials: W
authors.lastname: Wehbeh
authors.forename: Sorana
authors.initials: S
authors.lastname: Segal-Maurer
authors.forename: James J
authors.initials: JJ
authors.lastname: Rahal
authors.forename: Brian
authors.initials: B
authors.lastname: Johnston
authors.forename: Carl
authors.initials: C
authors.lastname: Urban
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011379:Prognosis; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases