title: [Characterisation of a CTX-M-15-producing Shigella sonnei in a Spanish patient who had not travelled abroad].
abstract: One hundred and seven Shigella spp. strains were isolated in our laboratory during the years 2000 to 2010. One Shigella sonnei harboured the genes that coded the β-lactamases TEM-1 and CTX-M-15, identifying the structure, ISEcp1+bla(CTX-M-15)+orf477, in their genetic environment. The strain also carried a class 2 integron with the gene cassettes dfrA1+sat+aadA1. A plasmid group IncI1 ST31 (CC-31) was detected and its mobilization by conjugation was demonstrated. We describe for the first time a S. sonnei strain producing a CTX-M-15 β-lactamase recovered from a Spanish patient who had not travelled abroad.
authors.affiliation: Servicio de Microbiología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. cseral@unizar.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Seral
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rojo-Bezares
authors.forename: Ana
authors.initials: A
authors.lastname: Garrido
authors.forename: María José
authors.initials: MJ
authors.lastname: Gude
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Sáenz
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Castillo
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis / Q000235:genetics*; D003227:Conjugation, Genetic; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004405:Dysentery, Bacillary / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D032023:Integrons / Q000235:genetics; D011815:R Factors / Q000235:genetics*; D012764:Shigella sonnei / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D013030:Spain; D001618:beta-Lactamases / Q000032:analysis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1