title: Selective ozone concentrations may reduce the ischemic damage after a stroke.
abstract: Abstract   Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.
authors.affiliation: Dipartimento di Neuroscienze, Sezione di Farmacologia, Universit à degli Studi di Siena, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Frosini
authors.forename: Antonella
authors.initials: A
authors.lastname: Contartese
authors.forename: Iacopo
authors.initials: I
authors.lastname: Zanardi
authors.forename: Valter
authors.initials: V
authors.lastname: Travagli
authors.forename: Velio
authors.initials: V
authors.lastname: Bocci
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology; D006624:Hippocampus / Q000098:blood supply / Q000473:pathology; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology; D066298:In Vitro Techniques; D010100:Oxygen / Q000627:therapeutic use; D010126:Ozone / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species; D010126:Ozone; D010100:Oxygen