title: Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines.
abstract: Three scaffolds of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines were synthesized via Ugi/de-protection/cyclization methodology. Benzimidazole forming ring closure was enabled under microwave irradiation in the presence of 10% TFA/DCE. The methodology demonstrates the utility of 2-(N-Boc-amino)-phenyl-isocyanide for the generation of new molecular diversity.
authors.affiliation: Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, BIO5 Oro Valley, Tucson, AZ, USA.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xu
authors.forename: Arthur Y
authors.initials: AY
authors.lastname: Shaw
authors.forename: Justin
authors.initials: J
authors.lastname: Dietrich
authors.forename: Alexandra P
authors.initials: AP
authors.lastname: Cappelli
authors.forename: Gary
authors.initials: G
authors.lastname: Nichol
authors.forename: Christopher
authors.initials: C
authors.lastname: Hulme
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D008968:Molecular Conformation; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D014965:X-Rays
chemical_list: D001562:Benzimidazoles; D011804:Quinolines; C009712:bis-benzimidazole; C031000:benzimidazole