title: Decreased serum testosterone levels in long-term adult survivors with fatty liver after childhood stem cell transplantation.
abstract: Fatty liver and male gonadal dysfunction are potential late effects of therapy in adult survivors treated with stem cell transplantation (SCT) in childhood. Obesity and metabolic syndrome also are associated with low serum testosterone levels in the general population. However, the relationship between the degree of fatty liver and changes in serum testosterone levels in adult survivors has not been fully studied. We reviewed the clinical records of 34 male patients who received allogeneic SCT in childhood or adolescence. The median age at SCT was 10.0 years, and the median follow-up after SCT was 15.9 years. All but one patient showed no tendency toward overweight/obesity during the follow-up period. Fatty liver was diagnosed by ultrasound in 15 patients at 4 to 20 years after SCT. Patients who received cranial radiation therapy before SCT were more likely to develop fatty liver and insulin resistance. Moreover, fatty liver was statistically associated with decreased serum testosterone levels, whereas nonfatty liver was not (median, 527 ng/dL [range, 168-944 ng/dL] versus 302 ng/dL [165-698 ng/dL]; P < .0001). Changes in testosterone levels after SCT are affected not only by primary gonadal dysfunction but also by subsequent development or exacerbation of fatty liver.
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hyodo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishiguro
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tomita
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takakura
authors.forename: Takashi
authors.initials: T
authors.lastname: Koike
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yabe
authors.forename: Miharu
authors.initials: M
authors.lastname: Yabe
authors.forename: Sei-ichiro
authors.initials: S
authors.lastname: Kojima
authors.forename: Koichi
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Minemura
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kato
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D005234:Fatty Liver / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D005500:Follow-Up Studies; D005720:Gamma Rays / Q000009:adverse effects; D006066:Gonads / Q000528:radiation effects; D019337:Hematologic Neoplasms / Q000532:radiotherapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000528:radiation effects; D008099:Liver / Q000000981:diagnostic imaging / Q000528:radiation effects; D008297:Male; D017741:Survivors; D013739:Testosterone / Q000097:blood*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D013739:Testosterone