title: Effects of curcumin and related compounds on processes involving α-hydroxyethyl radicals.
abstract: Effects of curcumin and related compounds on product formation in radiolysis of aerated and deaerated ethanol were studied. Ab initio calculations of enthalpy values relating to O-H bond dissociation and H-atom addition to > C = O bonds of the compounds under study have been performed. The obtained data allowed the conclusion that the presence of a 7-carbon chain containing conjugated > C = C < and > C = O bonds in the structures of curcumin and its analogues makes these compounds capable of inhibiting the reactions involving α-hydroxyl-containing carbon-centered radicals. This finding broadens the existing views concerning radical-regulating properties of curcuminoids, and it should be taken into account when practical use of these compounds is envisaged.
authors.affiliation: Department of Chemistry, Belarussian State University, Nezavisimosti av. 4, Minsk, Republic of Belarus.
authors.forename: Sviatoslav Dmitrievich
authors.initials: SD
authors.lastname: Brinkevich
authors.forename: Natalia Ivanovna
authors.initials: NI
authors.lastname: Ostrovskaya
authors.forename: Margaret Evgenievna
authors.initials: ME
authors.lastname: Parkhach
authors.forename: Svetlana Nikolaevna
authors.initials: SN
authors.lastname: Samovich
authors.forename: Oleg I
authors.initials: OI
authors.lastname: Shadyro
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives; D000447:Aldehydes / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D002599:Chalcone / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology*; D000431:Ethanol / Q000528:radiation effects; D005609:Free Radicals; D006139:Guaiacol / Q000494:pharmacology; D006588:Hexanones / Q000494:pharmacology; D006859:Hydrogen; D015394:Molecular Structure; D010100:Oxygen; D010422:Pentanones / Q000494:pharmacology; D011675:Pulse Radiolysis; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000494:pharmacology; D013816:Thermodynamics
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D005609:Free Radicals; D006588:Hexanones; D010422:Pentanones; D013343:Styrenes; C075384:coniferaldehyde; D000431:Ethanol; D002599:Chalcone; D006139:Guaiacol; C008374:mesityl oxide; D000171:Acrolein; D006859:Hydrogen; C052933:methyl-3-methoxy-4-hydroxystyryl ketone; C533260:dibenzylidene acetone; D003474:Curcumin; D010100:Oxygen