title: In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice.
abstract: BACKGROUND
  Bridelia ferruginea Benth (Euphorbiaceae) is an indigenous medicinal plant in Nigeria. It is usually a gnarled shrub which sometimes reaches the size of a tree in suitable condition. Decoctions of parts of this plant have been employed in ethno medicine in many parts of Africa for treatment of many ailments including malaria fever.
  
  
  OBJECTIVE
  In vivo antiplasmodial activity of aqueous stem bark extract of BF was investigated against Plasmodium berghei-infected mice.
  
  
  METHODS
  The aqueous stem bark extract of BF (100-400 mg/kg) was administered orally to P. berghei-infected mice in both early and established models of antiplasmodial studies.
  
  
  RESULTS
  The extract exhibited significant (p < 0.05) antiplasmodial activity in early and established infection tests with a considerable mean survival time comparable to that of chloroquine, 10 mg/kg. The oral LD(50) obtained was greater than 5000 mg/kg in mice.
  
  
  CONCLUSIONS
  The findings show that aqueous stem bark extract of Bridelia ferruginea possesses considerable antiplasmodial activity which can be developed in malaria therapy.
authors.affiliation: Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B 21 Garki, Abuja, Nigeria. mbaccc@yahoo.com
authors.forename: Chukwuemeka C
authors.initials: CC
authors.lastname: Mbah
authors.forename: Godwin C
authors.initials: GC
authors.lastname: Akuodor
authors.forename: Ngozi A
authors.initials: NA
authors.lastname: Anyalewechi
authors.forename: Tom C
authors.initials: TC
authors.lastname: Iwuanyanwu
authors.forename: Uche A
authors.initials: UA
authors.lastname: Osunkwo
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D007928:Lethal Dose 50; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D051379:Mice; D009549:Nigeria; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018547:Plant Stems; D010962:Plasmodium berghei / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine