title: Clinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents in children.
abstract: OBJECTIVE
  Procedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department.
  
  
  RESULTS
  Numerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized.
  
  
  CONCLUSIONS
  We review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.
authors.affiliation: Division of Emergency Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. cyril.sahyoun@childrens.harvard.edu
authors.forename: Cyril
authors.initials: C
authors.lastname: Sahyoun
authors.forename: Baruch
authors.initials: B
authors.lastname: Krauss
mesh_terms: D001007:Anxiety / Q000517:prevention & control; D002648:Child; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods*; D004334:Drug Administration Schedule; D004636:Emergency Service, Hospital; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D010146:Pain / Q000517:prevention & control
chemical_list: D006993:Hypnotics and Sedatives