title: Towards a more realistic biomechanical modelling of breast malignant tumours.
abstract: We develop a biomechanical model of an isolated stellate breast tumour under mammographic compression forces for a range of reported mechanical properties, both linear elastic and hyperelastic. We also introduce different volumes of increased density/stiffness around the tumour as well as a solid pressure effect. We show that each of these issues--well known to clinicians but ignored to date in models--has a non-negligible effect on stresses and strains/deformations.
authors.affiliation: Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK. cwessel@robots.ox.ac.uk
authors.forename: Carolina
authors.initials: C
authors.lastname: Wessel
authors.forename: Julia A
authors.initials: JA
authors.lastname: Schnabel
authors.forename: Michael
authors.initials: M
authors.lastname: Brady
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D003094:Collagen / Q000737:chemistry; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods; D004548:Elasticity; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods*; D008953:Models, Anatomic; D008962:Models, Theoretical; D013314:Stress, Mechanical
chemical_list: D003094:Collagen