title: Is human cytomegalovirus a target in cancer therapy?
abstract: Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV has been shown to inhibit tumour growth in preclinical models. Here we describe the possible involvement of HCMV in cancer and discuss the potential molecular impact expression of HCMV proteins have on tumour cells and the surrounding tumour microenvironment.
authors.affiliation: Childhood Cancer Research Unit, Department of Women´s and Children´s Health, Karolinska Institute, 171 76 Stockholm, Sweden. joinjo@ki.se
authors.forename: John Inge
authors.initials: JI
authors.lastname: Johnsen
authors.forename: Ninib
authors.initials: N
authors.lastname: Baryawno
authors.forename: Cecilia
authors.initials: C
authors.lastname: Söderberg-Nauclér
mesh_terms: D003587:Cytomegalovirus / Q000187:drug effects / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000821:virology*; D014411:Neoplastic Stem Cells / Q000821:virology; D059016:Tumor Microenvironment