title: Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin.
abstract: The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. The photoprotection was determined in vitro (antioxidant activity) and in vivo on UV-irradiated hairless mouse skin. The hydration effects were performed with the application of the formulations under study on the forearm of human volunteers and skin conditions were analyzed before and after a single application and daily applications during 4 weeks in terms of transepidermal water loss (TEWL), skin moisture and viscoelastic properties. The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. After 4 weeks of application on human skin, the formulation under study enhanced stratum corneum skin moisture and also showed hydration effects in deeper layers of the skin. Thus, it can be concluded that the cosmetic formulation containing a dispersion of liposome with MAP, ALA and kinetin under study showed photoprotective effects in skin barrier function as well as pronounced hydration effects on human skin, which suggests that this dispersion has potential antiaging effects.
authors.affiliation: Departamento de Ciências Farmacêuticas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil. pmcampos@usp.br
authors.forename: Patrícia Maria Berardo Gonçalves Maia
authors.initials: PM
authors.lastname: Campos
authors.forename: Flávio Bueno
authors.initials: FB
authors.lastname: de Camargo Júnior
authors.forename: Jirrah Pedro
authors.initials: JP
authors.lastname: de Andrade
authors.forename: Lorena Rigo
authors.initials: LR
authors.lastname: Gaspar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry*; D003358:Cosmetics; D007701:Kinetin / Q000737:chemistry*; D008081:Liposomes; D017616:Magnesium Compounds / Q000737:chemistry*; D051379:Mice; D008812:Mice, Hairless; D010710:Phosphates / Q000737:chemistry*; D008063:Thioctic Acid / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D003358:Cosmetics; D008081:Liposomes; D017616:Magnesium Compounds; D010710:Phosphates; C030781:magnesium phosphate; D008063:Thioctic Acid; D007701:Kinetin; D001205:Ascorbic Acid