title: Hemostimulating effects of erythropoietin immobilized by the nanotechnology method of electron-beam synthesis.
abstract: The hemostimulating effect of erythropoietin immobilized by the nanotechnology method of electron-beam synthesis was studied on the model of carboplatin-induced myelosuppression. Subcutaneous injection or oral administration of immobilized erythropoietin was followed by stimulation of erythropoiesis. The effect was most pronounced after parenteral treatment with this agent. The increase in proliferative activity and maturation of erythroid precursor cells serve as a factor determining acceleration of reparative processes in the hemopoietic tissue.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Novosibirsk, Russia. mmu@pharm.tsu.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: A V
authors.initials: AV
authors.lastname: Artamonov
authors.forename: A A
authors.initials: AA
authors.lastname: Bekarev
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: D N
authors.initials: DN
authors.lastname: Kinsht
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
mesh_terms: D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D016190:Carboplatin; D002452:Cell Count; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry*; D004921:Erythropoietin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects; D055767:Immobilized Proteins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008808:Mice, Inbred CBA; D036103:Nanotechnology; D011092:Polyethylene Glycols / Q000737:chemistry*; D012156:Reticulocytes / Q000187:drug effects / Q000473:pathology
chemical_list: D004337:Drug Carriers; D055767:Immobilized Proteins; D004921:Erythropoietin; D011092:Polyethylene Glycols; D016190:Carboplatin