title: Integrated dataset of screening hits against multiple neglected disease pathogens.
abstract: New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.
authors.affiliation: Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland. nwakas@who.int
authors.forename: Solomon
authors.initials: S
authors.lastname: Nwaka
authors.forename: Dominique
authors.initials: D
authors.lastname: Besson
authors.forename: Bernadette
authors.initials: B
authors.lastname: Ramirez
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.forename: An
authors.initials: A
authors.lastname: Matheeussen
authors.forename: Quentin
authors.initials: Q
authors.lastname: Bickle
authors.forename: Nuha R
authors.initials: NR
authors.lastname: Mansour
authors.forename: Fouad
authors.initials: F
authors.lastname: Yousif
authors.forename: Simon
authors.initials: S
authors.lastname: Townson
authors.forename: Suzanne
authors.initials: S
authors.lastname: Gokool
authors.forename: Fidelis
authors.initials: F
authors.lastname: Cho-Ngwa
authors.forename: Moses
authors.initials: M
authors.lastname: Samje
authors.forename: Shailja
authors.initials: S
authors.lastname: Misra-Bhattacharya
authors.forename: P K
authors.initials: PK
authors.lastname: Murthy
authors.forename: Foluke
authors.initials: F
authors.lastname: Fakorede
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Paris
authors.forename: Clive
authors.initials: C
authors.lastname: Yeates
authors.forename: Robert
authors.initials: R
authors.lastname: Ridley
authors.forename: Wesley C
authors.initials: WC
authors.lastname: Van Voorhis
authors.forename: Timothy
authors.initials: T
authors.lastname: Geary
mesh_terms: D000977:Antiparasitic Agents / Q000302:isolation & purification*; D055808:Drug Discovery / Q000639:trends; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D058069:Neglected Diseases / Q000188:drug therapy*; D010272:Parasitic Diseases / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents