title: Organocatalytic enantioselective synthesis of 2,3-dihydropyridazines.
abstract: We have developed an efficient procedure for the easy and straightforward preparation of functionalized dihydropyridazines as highly enantiopure materials by reaction of pyruvaldehyde 2-tosyl hydrazone with a variety of α,β-unsaturated aldehydes using a chiral secondary amine as catalyst. The overall process consists of a cascade reaction involving an initial aza-Michael reaction, in which the stereocentre is installed, followed by an intramolecular aldol reaction/dehydration step.
authors.affiliation: Department of Organic Chemistry II, UPV/EHU, P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Maitane
authors.initials: M
authors.lastname: Fernández
authors.forename: Jose L
authors.initials: JL
authors.lastname: Vicario
authors.forename: Efraím
authors.initials: E
authors.lastname: Reyes
authors.forename: Luisa
authors.initials: L
authors.lastname: Carrillo
authors.forename: Dolores
authors.initials: D
authors.lastname: Badía