title: Correction of endothelial dysfunction in patients with arterial hypertension.
abstract: We examined 38 patients (mean age 55.92 ± 1.56 years) with a 3-5-year history of arterial hypertension. The study showed that hypertension is accompanied by endothelial dysfunction and one of its forming factors is activation of the inflammatory response. Highly sensitive diagnostic tests can verify initiation of inflammation in preclinical manifestations. The use of nonsteroidal anti-inflammatory drugs, irrespective of the tropism to cyclooxygenase forms, alleviates manifestations of endothelial dysfunction in patients with arterial hypertension.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Soloviev
authors.forename: N V
authors.initials: NV
authors.lastname: Kulakova
authors.forename: T A
authors.initials: TA
authors.lastname: Semiglazova
authors.forename: E V
authors.initials: EV
authors.lastname: Borodulina
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008875:Middle Aged; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein; D000068579:Celecoxib; D001241:Aspirin