title: Clinico-morphological parameters affecting survival of patients with advanced cervical cancer.
abstract: The aim of the study was to investigate the prognostic significance of selected clinico-morphological parameters including Ki-67 antigen expression and microvessel density. The data of 122 patients with squamous cell carcinoma, FIGO stages IB-IIIB and treated with radiochemotherapy and brachytherapy were studied. Significant prognostic factors for disease-free survival in univariate analysis were the FIGO stage and the presence of atypical mitoses in carcinoma cells. Multivariate Cox analysis confirmed prognostic significance of the FIGO stage and Ki-67 expression with regard to disease-free survival. With regard to overall survival, the most important prognostic factor was Ki-67 antigen expression. The data concerning the pretreatment status of these parameters may be helpful in clinical practice.
authors.affiliation: Department of Gynaecological Oncology, Centre of Oncology, Maria Skłodowska-Curie Memorial Institute, Cracow Branch, Poland. klimekmag@poczta.onet.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Klimek
authors.forename: Anna
authors.initials: A
authors.lastname: Kruczak
authors.forename: Janusz
authors.initials: J
authors.lastname: Ryś
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mularz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Halaszka
authors.forename: Marcin
authors.initials: M
authors.lastname: Przewoźnik
authors.forename: Julia
authors.initials: J
authors.lastname: Moskal
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sokołowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Urbański
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D008938:Mitosis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000628:therapy
chemical_list: D019394:Ki-67 Antigen