title: Novel short-duration heating balloon dilatation with uniform temperature distribution: the heating conditions to suppress neo-intimal hyperplasia.
abstract: We investigate the relation between the influences on smooth muscle cells and the chronic performances of our novel short-duration heating balloon dilatation to reveal the heating conditions which can suppress the neo-intimal hyperplasia after our heating dilatations. The temperature of prototype balloon catheter surface was measured during short-duration heating balloon dilatation ex vivo. There existed 2 °C temperature variations in the long direction of prototype balloon catheter at a maximum. The neo-intimal hyperplasia occupancy rate after our short-duration heating dilatations were measured in vivo porcine study. The neo-intimal hyperplasia was suppressed most at 75 °C in balloon peak temperature in vivo. The estimated dead rate of smooth muscle cells at this condition was about 13% by the Arrhenius equation. We think that the suppression of neo-intimal hyperplasia was obtained after our short-duration heating dilatation due to the proper decrease of smooth muscle cells by heating and no thermal damages to the adventitia and surrounding tissues.
authors.affiliation: Graduate School of Science and Technology, School of Fundamental Science andTechnology, KEIO University, Japan. m.kunio@ arai.appi.keio.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Kunio
authors.forename: N
authors.initials: N
authors.lastname: Shimazaki
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Sakurada
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation*; D006361:Heating / Q000295:instrumentation*; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D013552:Swine; D014159:Transducers; D017539:Tunica Intima / Q000503:physiopathology* / Q000528:radiation effects