title: The role of hydrogen peroxide and other reactive oxygen species in wound healing.
abstract: Wound healing is a complex physiological process important for tissue homeostasis. An acute injury initiates massive cell migration, proliferation and differentiation, synthesis of extracellular matrix components, scar formation and remodelling. Blood flow and tissue oxygenation are parts of the complex regulation of healing. Higher organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for vital processes such as healing leads to the production of a number of oxygen compounds that may have a defensive or informatory role. They may be harmful when present in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively.
authors.affiliation: Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biochemistry, Czech Republic. kanta@lfhk.cuni.cz
authors.forename: Jirí
authors.initials: J
authors.lastname: Kanta
mesh_terms: D006861:Hydrogen Peroxide / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide