title: Optical coherence tomography findings in autoimmune retinopathy.
abstract: OBJECTIVE
  To report optical coherence tomography (OCT) features of patients with autoimmune retinopathy.
  
  
  METHODS
  Consecutive case series.
  
  
  METHODS
  Eight patients who presented with unexplained loss of central vision, visual field defects, and/or photopsia were diagnosed with autoimmune retinopathy based on clinical features, electroretinogram (ERG) findings, and serum antiretinal antibody analysis. All patients underwent OCT testing of the macula and nerve fiber layer (NFL).
  
  
  RESULTS
  Outer retinal abnormalities and/or decreased macular thickness on OCT were seen in all patients. Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143±30 μm and 131±29 μm respectively). In all but 1 patient, loss of the photoreceptor layer or disruption of the photoreceptor outer and inner segment junction was noted. Three patients showed only mild to moderate focal NFL loss.
  
  
  CONCLUSIONS
  Retinal atrophy and reduced macular thickness on OCT are predominant features in patients with autoimmune retinopathy. OCT provides objective measures of retinal damage and may offer clues toward understanding the mechanism of visual dysfunction and the diagnosis of autoimmune retinopathy.
authors.affiliation: Department of Ophthalmology, University of Virginia Health System, Charlottesville, Virginia, USA. azinabazari@gmail.com
authors.forename: Azin
authors.initials: A
authors.lastname: Abazari
authors.forename: Souha S
authors.initials: SS
authors.lastname: Allam
authors.forename: Grazyna
authors.initials: G
authors.lastname: Adamus
authors.forename: Nicola G
authors.initials: NG
authors.lastname: Ghazi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D001369:Axons / Q000473:pathology; D001766:Blindness / Q000175:diagnosis; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000276:immunology / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields
chemical_list: D001323:Autoantibodies