title: Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity.
abstract: At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activity-dependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin II-positive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.
authors.affiliation: Department of Neuroscience, University of Minnesota, 2001 Sixth Street SE, Minneapolis, MN 55455, USA. ebner001@umn.edu
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Ebner
authors.forename: Xinming
authors.initials: X
authors.lastname: Wang
authors.forename: Wangcai
authors.initials: W
authors.lastname: Gao
authors.forename: Samuel W
authors.initials: SW
authors.lastname: Cramer
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000378:metabolism / Q000502:physiology*; D005420:Flavoproteins / Q000378:metabolism; D006801:Humans; D008606:Mental Processes / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011689:Purkinje Cells / Q000378:metabolism / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
chemical_list: D005420:Flavoproteins; D009419:Nerve Tissue Proteins; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; C071871:zebrin II