title: Effect of white matter anisotropy in modeling electroconvulsive therapy.
abstract: White matter in the brain exhibits strong anisotropic conductivity. Modeling studies on electroencephalography have found that such anisotropic conductivity greatly influences the estimated dipole source. In this study, we made a detailed comparison of the effects of conductivity anisotropy using a computational model of electroconvulsive therapy (ECT). The human head model was a high resolution finite element model generated from MRI scans, implemented with tissue heterogeneity and an excitable neural model incorporated in the brain. Results showed that anisotropy in conductivity had minimal effects on the location of the brain region that was maximally activated, but it had relatively large effects on deep brain structures.
authors.affiliation: Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Australia. s.bai@student.unsw.edu.au
authors.forename: Siwei
authors.initials: S
authors.lastname: Bai
authors.forename: Colleen
authors.initials: C
authors.lastname: Loo
authors.forename: Guangqiang
authors.initials: G
authors.lastname: Geng
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D016880:Anisotropy; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D004565:Electroconvulsive Therapy / Q000379:methods*; D006801:Humans; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D013813:Therapy, Computer-Assisted / Q000379:methods*