title: Uteroplacental arterio-venous difference in soluble VEGFR-1 (sFlt-1), but not in soluble endoglin concentrations in preeclampsia.
abstract: The aim was to determine plasma levels of sFlt-1 and sEng on the arterial and venous side of the uteroplacental circulation in preeclamptic patients and healthy controls. Preeclamptic patients had higher arterial concentrations than controls of sFlt-1 (17,450 vs. 5055 pg/ml, p = 0.003) and sEng (68.7 vs. 28.7 ng/ml, p = 0.003). In the preclampsia group sFlt-1 was higher in the uterine vein than in the radial artery (22,450 vs. 17,450 pg/ml, p = 0.005). We found no gradient for sEng. Our results support the hypothesis that excess sFlt-1 at least partly originates in placenta, while excess sEng appears to have a different origin.
authors.affiliation: Department of Obstetrics, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway. mcpaasche@hotmail.com
authors.forename: M C
authors.initials: MC
authors.lastname: Paasche Roland
authors.forename: B
authors.initials: B
authors.lastname: Lorentzen
authors.forename: K
authors.initials: K
authors.lastname: Godang
authors.forename: T
authors.initials: T
authors.lastname: Henriksen
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D000071063:Endoglin; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D021041:Placental Circulation / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D012995:Solubility; D014469:Umbilical Arteries / Q000737:chemistry / Q000378:metabolism; D014471:Umbilical Veins / Q000737:chemistry / Q000378:metabolism; D055988:Uterine Artery / Q000737:chemistry / Q000378:metabolism; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1