title: [Cytosolic protein quality control system--the role of molecular chaperones in the biology of neurodegenerative diseases].
abstract: In this article we describe the role of molecular chaperones and cellular proteases in the cytosolic protein quality control system that controls and regulates in all living organisms folding status of proteins and their proper function. Thanks to cooperative action of molecular chaperones and proteases the acumulation of misfolded proteins in the cytosol is limited. In particular, the links between chaperones to protein degradation and the role of molecular chaperones in the biology of neurodegnerative diseases are discussed.
authors.affiliation: Katedra Biochemii, Wydział Biologii, Uniwersytet Gdański, Gdańsk.
authors.forename: Izabela
authors.initials: I
authors.lastname: Guenther
authors.forename: Sabina
authors.initials: S
authors.lastname: Kedzierska-Mieszkowska
mesh_terms: D056404:Chaperonin Containing TCP-1 / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D017510:Protein Folding; D059748:Proteolysis; D014157:Transcription Factors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: C091732:BCL2-associated athanogene 1 protein; D004268:DNA-Binding Proteins; D018832:Molecular Chaperones; D014157:Transcription Factors; C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases; D056404:Chaperonin Containing TCP-1