title: Relationship between blood pressure, cholesterolemia and serum apolipoprotein B in a large population sample:  the Brisighella Heart Study.
abstract: OBJECTIVE
  The objective is to evaluate the relationship between cholesterolemia, serum apolipoprotein B (apoB) level and blood pressure in a large sample of general population.
  
  
  METHODS
  The Brisighella Heart Study (BHS) is a prospective, population-based longitudinal epidemiological investigation. For this study, we analysed the data sampled in the 2008 BHS population survey, excluding those participants treated with antihypertensive and/or lipid lowering drugs (N: 2473).
  
  
  RESULTS
  In a sex, BMI, smoking habit, physical activity level and serum creatinine adjusted model, low-density lipoprotein-cholesterol (LDL-C) appears to be significantly related to SBP (P < 0.001), DBP (P = 0.026), and pulse pressure (PP) (P < 0.001). In individuals aged less than 52 years, LDL-C was significantly associated to SBP and DBP (P < 0.001), but not PP. In the same model, apoB appears to be mildly but significantly related to SBP (P < 0.001), DBP (P < 0.001), and PP (P < 0.001). In individuals aged less than 52 years, apoB was significantly associated to SBP (P < 0.001), DBP (P < 0.001), and PP (P < 0.001). In individuals aged 52 or more, nor LDL-C neither apoB were significantly associated to blood pressure. Including in the same model LDL-C and apoB, apoB excluded the predicting role of LDL-C as it regards the blood pressure either in the whole population sample and in the younger individuals.
  
  
  CONCLUSIONS
  On the basis of our observation, either serum LDL-C and apoB are significantly related to the blood pressure level in a large sample of individuals untreated with antihypertensive and lipid-lowering drugs. This association is stronger in younger individuals than in elderly. ApoB seems to be a stronger predictor of either SBP, DBP and PP than LDL-C.
authors.affiliation: Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy.
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
authors.forename: Sergio
authors.initials: S
authors.lastname: D'Addato
authors.forename: Maddalena
authors.initials: M
authors.lastname: Veronesi
authors.forename: Martina
authors.initials: M
authors.lastname: Rosticci
authors.forename: Francesca
authors.initials: F
authors.lastname: Santi
authors.forename: Ada
authors.initials: A
authors.lastname: Dormi
authors.forename: Claudio
authors.initials: C
authors.lastname: Borghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood*; D001794:Blood Pressure; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL