title: Palladium-catalyzed direct arylation of pyridine N-oxide with 2-bromoacetanilides. Synthesis of benzisoxazolo[2,3-a]pyridinium tetrafluoroborates.
abstract: The synthesis of a variety of novel benzisoxazolo[2,3-a]pyridinium tetrafluoroborates is described. These compounds are conveniently prepared from pyridine N-oxide via a microwave-promoted palladium-catalyzed direct arylation of pyridine N-oxide with 2-bromoacetanilides to give 2-(2-acetamidoaryl)pyridine N-oxides, followed by hydrolysis, diazotization and intramolecular displacement of nitrogen which affords the target benzisoxazolo[2,3-a]pyridinium tetrafluoroborates.
authors.affiliation: Department of Chemistry, Physics, and Geology, Winthrop University, Sims Science Building, Rock Hill, SC 29733 USA.
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Myers
authors.forename: James M
authors.initials: JM
authors.lastname: Hanna