title: Granulosa cell tumors of the ovary and inhibin B.
abstract: We present the results of immunoenzyme detection of inhibin B in blood serum of patients with adult-type granulosa cell tumors of the ovary. Blood concentration of inhibin B at the end of menstrual cycle in patients with tumor relapse was significantly higher than in patients during remission and in virtually healthy women. The increase in inhibin B concentration preceded clinical manifestation of the disease relapse by 2-13 months, which demonstrates high diagnostic sensitivity of this marker and suggests that it can be recommended for the use in diagnostics and monitoring of granulosa cell tumors of the ovaries.
authors.affiliation: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. biochimia@mtu-net.ru
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: A M
authors.initials: AM
authors.lastname: Beyshembaev
authors.forename: D N
authors.initials: DN
authors.lastname: Kushlinskiy
authors.forename: K I
authors.initials: KI
authors.lastname: Zordania
authors.forename: L V
authors.initials: LV
authors.lastname: Adamyan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D006080:Ovarian Follicle / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis*; D010053:Ovary / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C422364:inhibin B; D007265:Inhibins