title: Chronic inflammatory demyelinating polyneuropathy due to the administration of pegylated interferon α-2b: a neuropathology case report.
abstract: We report a 35-year-old man who developed weakness in his extremities five months after pegylated interferon α (IFNα)-2b was administered. The serum tumor necrosis factor-α (TNFα) was elevated and nerve conduction studies revealed demyelination both in the distal and intermediate segments. The sural nerve pathology showed mild demyelinating process. The cessation of IFNα and administration of intravenous immunoglobulin improved both his clinical symptoms and the temporal dispersion in motor nerve conduction study. IFNα-induced CIDP is presumably a transient immunological condition that requires immunomodulatory therapy. The elevated serum TNFα may implicate the degree of downstream autoimmunity induced by IFNα.
authors.affiliation: Department of Neurology, Kyoto Prefectural University of Medicine, Japan. kenshiga@koto.kpu-m.ac.jp
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shiga
authors.forename: Eijiroh
authors.initials: E
authors.lastname: Tanaka
authors.forename: Reina
authors.initials: R
authors.lastname: Isayama
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
authors.forename: Kyoko
authors.initials: K
authors.lastname: Itoh
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011115:Polyneuropathies / Q000139:chemically induced* / Q000175:diagnosis*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b