title: Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii.
abstract: Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 μM, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 μM.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Amandajuan
authors.initials: A
authors.lastname: Chen
authors.forename: Xinhui
authors.initials: X
authors.lastname: Tian
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Chen
authors.forename: Hongwu
authors.initials: H
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhong-Mei
authors.initials: ZM
authors.lastname: Zou
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D003572:Cytochalasins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D060026:Endophytes / Q000737:chemistry; D005260:Female; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D053723:Panax notoginseng / Q000382:microbiology*; D014242:Trichoderma / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D003572:Cytochalasins; C430983:aspochalasin D; C574434:trichalasin C; C574435:trichalasin D