title: Novel immunotherapeutic strategies of gastric cancer treatment.
abstract: Gastric cancer (GC) is the fourth most common cancer and the second most frequent cause of cancer-related deaths, accounting for 10.4% of cancer deaths worldwide. Despite the improvements, estimated cure rates for patients with advanced stages remain poor, and in the metastatic setting, chemotherapy is the mainstay of palliative therapy and results in objective response rates (ORRs) of only 20-40% and median overall survivals (OS) of 8-10 months. Therefore, many investigators believe that the potential for making significant progress lies in understanding and exploiting the molecular biology of these tumors to investigate new therapeutic strategies to combat GC, such as specific immunotherapy. In this paper, we analyze the different approaches used for immune-based (especially dendritic and T cells) therapies to gastric cancer treatment and discuss the results obtained in preclinical models as in clinical trials.
authors.affiliation: Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. aamedei@unifi.it
authors.forename: Amedeo
authors.initials: A
authors.lastname: Amedei
authors.forename: Marisa
authors.initials: M
authors.lastname: Benagiano
authors.forename: Chiara
authors.initials: C
authors.lastname: della Bella
authors.forename: Elena
authors.initials: E
authors.lastname: Niccolai
authors.forename: Mario M
authors.initials: MM
authors.lastname: D'Elios
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000628:therapy*; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000628:therapy*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods; D013274:Stomach Neoplasms / Q000276:immunology / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D042461:Vascular Endothelial Growth Factor A