title: Acaricidal activity of extract from Eupatorium adenophorum against the Psoroptes cuniculi and Sarcoptes scabiei in vitro.
abstract: The possible acaricidal activity of Eupatorium adenophorum was analyzed using extracts created by water decocting, ethanol thermal circumfluence, and steam distillation. The toxic effect of each extract was tested against Psoroptes cuniculi and Sarcoptes scabiei in vitro. Ethanol thermal circumfluence extract had strong toxicity against mites, killing all S. scabiei at 0.5 and 1.0 g/ml (w/v) concentration, while 1g/ml extract was also found to kill all P. cuniculi within a 4-h period. Similarly, 0.25, 0.5 and 1.0 g/ml concentration of extract had strong toxicity against S. scabiei, with median lethal time (LT(50)) values at 0.866, 0.785 and 0.517 h, respectively. 0.5 g/ml and 1g/ml showed strong acaricidal action against P. cuniculi; the LT(50) values were 0.93 h and 1.29 h, respectively. The median lethal concentration (LC(50)) values were 0.22 g/ml for Scabies mite and 0.64 g/ml for P. cuniculi in 1h. The results indicated that E. adenophorum contains potent acaricidal ingredients; as a first step in the potential development of novel drugs, it may provide new acaricidal compounds for the effective control of animal acariasis.
authors.affiliation: Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Nong
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Fang
authors.forename: Jia-Hai
authors.initials: JH
authors.lastname: Wang
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Gu
authors.forename: De-Ying
authors.initials: DY
authors.lastname: Yang
authors.forename: Tian-Fei
authors.initials: TF
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Fu
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Zhang
authors.forename: Wan-Peng
authors.initials: WP
authors.lastname: Zheng
authors.forename: Xue-Rong
authors.initials: XR
authors.lastname: Peng
authors.forename: Shu-Xian
authors.initials: SX
authors.lastname: Wang
authors.forename: Guang-You
authors.initials: GY
authors.lastname: Yang
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000494:pharmacology*; D036603:Ageratina / Q000737:chemistry*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D040042:Psoroptidae / Q000187:drug effects*; D012520:Sarcoptes scabiei / Q000187:drug effects*
chemical_list: D056810:Acaricides; D010936:Plant Extracts