title: Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis.
abstract: We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is known to rarely cause granulomatous reactions, but this appears to be the first case of palisading neutrophilic granulomatous dermatitis induction. Possible mechanisms include immune complex deposition, an immune response directed against the metabolites of allopurinol, or allopurinol hypersensitivity exclusively localized to the skin.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami 33125, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Gordon
authors.forename: Maria
authors.initials: M
authors.lastname: Miteva
authors.forename: Daniele
authors.initials: D
authors.lastname: Torchia
authors.forename: Paolo
authors.initials: P
authors.lastname: Romanelli
mesh_terms: D000493:Allopurinol / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006074:Gout Suppressants / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol