title: Sesquiterpene lactones from Inula hookeri.
abstract: Four new sesquiterpene lactones, (1 S,5 R,6 S,7 S,8 R,9 R,10 S,11 S)-6-acetoxy-9-hydroxy-4-oxo-pseudoguai-2(3)-en-12,8-olide, (1 S,2 R,5 R,6 S,7 R,8 S,10 R)-6-acetoxy-2-ethoxy-4-oxo-pseudoguai-11(13)-en-12,8-olide, (1 S,2 R,5 R,6 S,7 R,8 S,10 R)-6-acetoxy-2-hydroxy-4-oxo-pseudoguai-11(13)-en-12,8-olide, and 14-acetoxy-1 β,5 α,7 αH-4 β-hydroxy-guai-9(10),11(13)-dien-12,8 α-olide, along with 26 known sesquiterpene lactones, were isolated from the whole plants of Inula hookeri C. B. Clarke. Their structures were established based on spectroscopic methods including HRESIMS, 1D and 2D NMR, and CD techniques. All compounds were evaluated for their cytotoxic activities against HepG2, HeLa, PC-3, and MGC-803 cell lines by CCK-8 assay. Some of the isolates, especiallly pseudoguaianolides and guaianolides, exhibited significant cytotoxicities against these four examined cell lines.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Shou-De
authors.initials: SD
authors.lastname: Zhang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D001681:Biological Assay; D045744:Cell Line, Tumor; D002470:Cell Survival; D002681:China; D005260:Female; D006801:Humans; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes