title: The importance of radiographic imaging in the microscopic assessment of bone tumors.
abstract: BACKGROUND
  Primary bone tumors are rare and require a multidisciplinary approach. Diagnosis involves primarily the radiologist and the pathologist. Bone lesions are often heterogeneous and the microscopic diagnostic component(s) may be in the minority, especially on core needle biopsies. Reactive processes, benign, and malignant tumors may have similar microscopic aspects. For these challenging cases, the correlation of microscopic and radiologic information is critical, or diagnostic mistakes may be made with severe clinical consequences for the patient. The purpose of this article is to explain how pathologists can best use imaging studies to improve the diagnostic accuracy of bone lesions.
  
  
  METHODS
  Many bone lesions are microscopically and/or radiographically heterogeneous, especially those with both lytic and matrix components. Final diagnosis may require specific microscopic diagnostic features that may be present in the lesion, but not the biopsy specimen. A review of the imaging helps assess if sampling was adequate. The existence of a pre-existing bone lesion, syndrome (such as Ollier disease or multiple hereditary exostosis), or oncologic history may be of crucial importance. Finally, imaging information is very useful for the pathologist to perform accurate local and regional staging during gross examination.
  
  
  CONCLUSIONS
  Close teamwork between pathologists, radiologists, and clinicians is of utmost importance in the evaluation and management of bone tumors. These lesions can be very difficult to interpret microscopically; imaging studies therefore play a crucial role in their accurate diagnosis.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Department of pathology, Rizzoli Institute, Bologna, Italy. Electronic address: frederique.larousserie@cch.aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Larousserie
authors.forename: J
authors.initials: J
authors.lastname: Kreshak
authors.forename: M
authors.initials: M
authors.lastname: Gambarotti
authors.forename: M
authors.initials: M
authors.lastname: Alberghini
authors.forename: D
authors.initials: D
authors.lastname: Vanel
mesh_terms: D062005:Biopsy, Large-Core Needle / Q000379:methods*; D001859:Bone Neoplasms / Q000175:diagnosis*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D009367:Neoplasm Staging