title: Fluorescent dye-doped silica nanoparticles: new tools for bioapplications.
abstract: The need to decipher various biological events has led to the elucidation of the molecular mechanisms underlying a number of disease processes. Consequently, the detection and simultaneous monitoring of chemical interactions between biological targets has become indispensable in medical diagnosis, targeted therapeutics, and molecular biology. Multiplexed applications employing nanomaterials, which represent the integration of nanotechnology and biology, have changed the bioanalytical outlook and provided various promising tools. Among these nanomaterials, fluorescent dye-doped silica nanoparticles have demonstrated excellent potential for use in advanced bioanalysis to facilitate deeper understanding of biology and medicine at the molecular level. In particular, silica nanoparticles have been applied to diagnostics and therapeutic applications in cancer and gene/drug delivery. This feature article summarizes recent developments in the synthesis, biocompatibility, and bioapplications of fluorescent dye-doped silica nanoparticles.
authors.affiliation: Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
authors.forename: Se Won
authors.initials: SW
authors.lastname: Bae
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
authors.forename: Jong-In
authors.initials: JI
authors.lastname: Hong
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001812:Blood-Brain Barrier / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000737:chemistry*; D007118:Immunoassay; D008163:Luminescent Measurements; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D020411:Oligonucleotide Array Sequence Analysis; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D012822:Silicon Dioxide