title: [Research advances in the treatment of hyperhomocysteinemia].
abstract: Homocysteine is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia which is caused by abnormal homocysteine metabolism has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis, chronic kidney disease. In this paper, we first briefly introduced hyperhomocysteinemia and its pathogenesis, then summarized the treatment advances of hyperhomocysteinemia using folic acid, vitamin B6, B12, betaine, atorvastatin, isoflavones, taurine and some Chinese traditional medicine. Finally, the potential problems of the various treatment methods were analyzed.
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Si
authors.initials: S
authors.lastname: Cheng
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001622:Betaine / Q000627:therapeutic use*; D005492:Folic Acid / Q000627:therapeutic use*; D015316:Genetic Therapy; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology / Q000628:therapy*; D013654:Taurine / Q000627:therapeutic use*
chemical_list: D013654:Taurine; D001622:Betaine; D005492:Folic Acid