title: Reactions of granulocytic lineage of hemopoiesis and mechanisms of their development in combined treatment with adriablastin and taxotere.
abstract: We studied myelotoxic effects of adriablastin and taxotere combination on granulocytic lineage cells and processes of their recovery in patients with stage III-IV breast cancer. Intensive maturation of granulocytic CFU provided regeneration of the hemopoiesis even under conditions of reduced proliferative activity of these cells, which, in turn, led to accumulation of mature and immature neutrophilic granulocytes in the bone marrow and improved reserve capacities of the neutrophil pool in the bone marrow.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: V A
authors.initials: VA
authors.lastname: Shatalova
authors.forename: N O
authors.initials: NO
authors.lastname: Popova
authors.forename: E S
authors.initials: ES
authors.lastname: Burshtein
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols; D001854:Bone Marrow Cells / Q000187:drug effects; D001943:Breast Neoplasms; D049109:Cell Proliferation / Q000187:drug effects; D000077143:Docetaxel; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D043823:Taxoids / Q000494:pharmacology*
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin