title: [Peculiarities of relationship between atrophic gastritis and stomach cancer in the population of East Siberia].
abstract: The authors studied the relationship between atrophic gastritis and gastric cancer in Europeoid and Mongoloid populations of East Siberia. Screening for atrophic gastritis was carried out in parallel in Evenkia, Khakassia, and Tyva. 1492 Europeoids, 533 Khakasses, 493 Evenks, and 414 Tuvinians were examined by oesogastroduodenoscopy with simultaneous biopsy sampling. Morphological studies of gastric mucosa were performed by light microscopy of hematoxylin/eosin stained samples with evaluation of results based on the visual analogous scale. H.pylori was identified in Giemsa stain preparations. Immunoenzyme assay was used to detect IgG and IgG of H.pylori CagA. Gastric cancer morbidity was estimated using materials of local oncological dispensaries and autopsy data. The prevalence of antral atrophic gastritis was 25.8% in Europeoids, 15.2% in Khakasses, 14% in Evenks, and 25.8% in Tuvinians. The incidence of gastric cancer was 33.2 in Europeoids, 20.2 in Khakasses, and 50.7in Tuvinians per 100,000. The occurrence of H.pylori was similar in all these populations (roughly 90%). CagA strains were identified in 61.2% Europeoids, in 44% Khakasses, in 36.44% Evenks, and in 60% Tuvinians. The study revealed ethnic differences in the association between gastritis cancer and H.pylori CagA-related gastritis among populations of different regions of East Siberia.
mesh_terms: D044466:Asian People / Q000208:ethnology; D004384:Duodenoscopy; D005753:Gastric Mucosa / Q000166:cytology* / Q000473:pathology; D005757:Gastritis, Atrophic / Q000208:ethnology* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D012800:Siberia / Q000208:ethnology; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000209:etiology; D044465:White People / Q000208:ethnology