title: UPEC hemolysin: more than just for making holes.
abstract: During acute cystitis, uropathogenic Escherichia coli (UPEC) induce bladder epithelial cell exfoliation, which eliminates infected cells and promotes UPEC dissemination. Dhakal and Mulvey (2012) uncover the mechanism that induces this exfoliation and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets multiple host pathways to facilitate infection.
authors.affiliation: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. sheryl.justice@nationwidechildrens.org
authors.forename: Sheryl S
authors.initials: SS
authors.lastname: Justice
authors.forename: David A
authors.initials: DA
authors.lastname: Hunstad
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D029968:Escherichia coli Proteins / Q000633:toxicity*; D006460:Hemolysin Proteins / Q000633:toxicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D057057:Serine Proteases / Q000378:metabolism*; D015398:Signal Transduction; D056689:Uropathogenic Escherichia coli / Q000472:pathogenicity*
chemical_list: D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; C036507:Hlya protein, E coli; D057057:Serine Proteases