title: Aging, prospective memory, and health-related quality of life in HIV infection.
abstract: HIV infection and older age are each independently associated with lower health-related quality of life (HRQoL) and deficits in prospective memory (PM), which is a distinct aspect of cognition involving the ability to "remember to remember" to do something at a future occasion. The present study investigated associations between PM and HRQoL in 72 older (≥ 50 years) and 41 younger (≤ 40 years) HIV-infected adults. Self-reported PM complaints predicted HRQoL across the entire sample, but there was a significant interaction between performance-based PM and age group on HRQoL, such that lower time-based PM was associated with lower HRQoL only in the younger cohort. Within the younger group, time-based and self-reported PM significantly predicted mental HRQoL independent of other risk factors (e.g. depression). These findings suggest that PM plays a unique role in HRQoL outcomes among younger persons living with HIV infection and support the examination of other age-related factors (e.g. effective use of compensatory strategies) that may regulate the adverse impact of PM on everyday functioning.
authors.affiliation: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, San Diego, CA, 92093, USA. kldoyle@ucsd.edu
authors.forename: Katie
authors.initials: K
authors.lastname: Doyle
authors.forename: Erica
authors.initials: E
authors.lastname: Weber
authors.forename: J Hampton
authors.initials: JH
authors.lastname: Atkinson
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology / Q000523:psychology*; D002140:California; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000523:psychology*; D006304:Health Status; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis; D012307:Risk Factors; D057566:Self Report; D012959:Socioeconomic Factors; D013997:Time Factors; D055815:Young Adult