title: [Clinical significances of serum NO and oxLDL in obstructive sleep apnea-hypopnea syndrome].
abstract: OBJECTIVE
  To study the correlation between the serum levels of nitrogen oxide (NO) and oxidized low density lipoprotein (oxLDL) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
  
  
  METHODS
  NO and oxLDL levels were measured in 60 OSAHS patients and 26 healthy subjects. OSAHS patients were divided into mild, moderate and severe groups according to AHI.
  
  
  RESULTS
  NO levels in the moderate and sever OSAHS groups was significantly lower than that in the control group, but the levels of oxLDL was increased compared with the control group. (P < 0.05). The serum levels of NO was negatively correlated with AHI (P < 0.01) and positively correlated with the lowest SaO2 (P < 0.01), the serum levels of oxLDL was positively correlated with AHI (P < 0.01) and negatively correlated with the lowest SaO2 (P < 0.01), NO levels showed negative correlations with oxLDL levels (P < 0.01).
  
  
  CONCLUSIONS
  The serum level of NO is reduced in response to the increase of AHI and the acceleration of hypoxia, which indicated that there is a correlation between vascular endothelial dysfunction and the severity of hypoxia. The decrease of the level of NO and the increase of the oxLDL can promote the formation of atherosclerosis, which increased the incidence of cardiocerebrovascular disease in patients with OSAHS.
authors.affiliation: Department of Otorhinolaryngology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. qdsleep@yahoo.com.cn
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Jiang
authors.forename: Jinhui
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D044967:Serum / Q000737:chemistry; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide