title: [Effect of Astragalus and Salvia's effective components and their compatibility on JAK/STAT pathway].
abstract: OBJECTIVE
  To study the effect of Astragalus and Salvia's effective components and their compatibility on JAK/STAT pathway of rats' renal fibrosis.
  
  
  METHODS
  66 SD rats were randomly divided into 7 groups: normal group,model group,fosinopril group, salvianolic acids group, astragalus saponins group, granules compatibility of Astragalus and Salvia group, components combination of Astragalus and Salvia group. The variation of beta2-microglobulin(beta2-MG), the changes of renal pathology and JAK/STAT pathway were observed.
  
  
  RESULTS
  The changes in renal pathology of treatment groups had different degrees of improvement; Astragalus and Salvia could reduce the urinary beta2-MG of unilateral ureteral obstruction (UUO) rat (P < 0.05), which was equal with fosinopril group. The rest of the treatment groups decreased especially fosinopril group while the difference was not significant when compared with the model group. Astragalus and its effective components could reduce the expression of renal tissue JAK, STAT1, STAT3 protein, among which fosinopril group and granules compatibility of Astragalus decreased significantly. Astragalus saponins group was not obvious, and the rest of the treatment group had significantly minor effect.
  
  
  CONCLUSIONS
  Astragalus and Salvia's effective components and their compatibility may protect renal tubular function in unilateral ureteral obstruction, which may interfere with UUO rat kidney with JAK/STAT signaling pathway.
authors.affiliation: Department of Traditional Chinese Medicine, Fifth Affiliated Hospital of Zunyi Medical College in Zhuhai, Zhuhai 519100, China. lijun69-1214@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Cao
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Yang
mesh_terms: D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005355:Fibrosis; D017328:Fosinopril / Q000008:administration & dosage / Q000494:pharmacology; D053612:Janus Kinases / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D050791:STAT Transcription Factors / Q000378:metabolism*; D027544:Salvia / Q000737:chemistry*; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology; D015398:Signal Transduction; D014517:Ureteral Obstruction / Q000378:metabolism* / Q000473:pathology; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D050791:STAT Transcription Factors; D012503:Saponins; D001613:beta 2-Microglobulin; D053612:Janus Kinases; D017328:Fosinopril