title: Simian foamy virus prevalence in Macaca mulatta and zookeepers.
abstract: The simian foamy virus (SFV) has been reported to be transmissible among humans occupationally exposed to nonhuman primates. Nevertheless, epidemiological and genotypic data on the SFV in Macaca mulatta and zookeepers in China are limited. In the present study, SFV proviral DNA was detected in 74 blood samples from M. mulatta and 12 saliva specimens from zookeepers by nested polymerase chain reaction. A total of 29 blood samples from M. mulatta (29/74, 39.19%) and two saliva specimens from zookeepers (2/12, 16.67%) were positive. The phylogenetic analysis indicated that these SFV strains shared the highest homology with Macaca fascicularis (93.4%). The two SFV strains infected human beings, and shared the highest homology of 98.6% with each other as well as 90.8-99.5% with M. mulatta. The investigation revealed the high prevalence of the SFV in M. mulatta in China and its zoonotic transmission to humans.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China. huangfen6789@163.com
authors.forename: Fen
authors.initials: F
authors.lastname: Huang
authors.forename: Huixuan
authors.initials: H
authors.lastname: Wang
authors.forename: Shenrong
authors.initials: S
authors.lastname: Jing
authors.forename: Weikun
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000302:isolation & purification; D006801:Humans; D008253:Macaca mulatta; D016273:Occupational Exposure / Q000009:adverse effects*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012192:Retroviridae Infections / Q000453:epidemiology / Q000378:metabolism / Q000635:transmission*; D053150:Simian foamy virus / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism / Q000472:pathogenicity; D015047:Zoonoses / Q000821:virology
chemical_list: D004279:DNA, Viral