title: Serum cystatin C reflects the progress of albuminuria.
abstract: BACKGROUND
  Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.
  
  
  METHODS
  We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.
  
  
  RESULTS
  With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.
  
  
  CONCLUSIONS
  Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jeong Seon
authors.initials: JS
authors.lastname: Yoo
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Eun Hae
authors.initials: EH
authors.lastname: Lee
authors.forename: Ji Woon
authors.initials: JW
authors.lastname: Kim
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ki-Cheon
authors.initials: KC
authors.lastname: Jeong
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Kang
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Nam
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Young Duk
authors.initials: YD
authors.lastname: Song
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim