title: Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.
abstract: Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner. However, the effect of SDR on the primary anti-viral immune response has not been elucidated. In this study, SDR-infected (INF) mice terminated viral gene expression earlier and mounted an enhanced pulmonary IAV-specific CD8(+)T cell response versus controls. Additionally, SDR-INF mice had a more pro-inflammatory lung profile prior to and during infection and an attenuated corticosterone response. These data demonstrate neuroendocrine modification of the lung microenvironment and increased antigen-specific T cell activation, clonal expansion and viral control in stress-exposed mice.
authors.affiliation: The Ohio State University, College of Dentistry, Section of Oral Biology, Columbus, OH 43218-2357, USA.
authors.forename: Jacqueline W
authors.initials: JW
authors.lastname: Mays
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Powell
authors.forename: John T
authors.initials: JT
authors.lastname: Hunzeker
authors.forename: Mark L
authors.initials: ML
authors.lastname: Hanke
authors.forename: Michael T
authors.initials: MT
authors.lastname: Bailey
authors.forename: John F
authors.initials: JF
authors.lastname: Sheridan
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016827:CD8 Antigens / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000276:immunology*; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology*; D013315:Stress, Psychological / Q000276:immunology / Q000473:pathology*; D013997:Time Factors
chemical_list: D016827:CD8 Antigens; D003345:Corticosterone