title: The functions of TRPA1 and TRPV1: moving away from sensory nerves.
abstract: The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) channels are members of the TRP superfamily of structurally related, non-selective cation channels. It is rapidly becoming clear that the functions of TRPV1 and TRPA1 interlink with each other to a considerable extent. This is especially clear in relation to pain and neurogenic inflammation where TRPV1 is coexpressed on the vast majority of TRPA1-expressing sensory nerves and both integrate a variety of noxious stimuli. The more recent discovery that both TRPV1 and TRPA1 are expressed on a multitude of non-neuronal sites has led to a plethora of research into possible functions of these receptors. Non-neuronal cells on which TRPV1 and TRPA1 are expressed vary from vascular smooth muscle to keratinocytes and endothelium. This review will discuss the expression, functionality and roles of these non-neuronal TRP channels away from sensory nerves to demonstrate the diverse nature of TRPV1 and TRPA1 in addition to a direct role in pain and neurogenic inflammation.
authors.affiliation: Cardiovascular Division, School of Medicine, King's College London, London, UK.
authors.forename: E S
authors.initials: ES
authors.lastname: Fernandes
authors.forename: M A
authors.initials: MA
authors.lastname: Fernandes
authors.forename: J E
authors.initials: JE
authors.lastname: Keeble
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D050051:Transient Receptor Potential Channels / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels