title: Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study.
abstract: BACKGROUND
  Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.
  
  
  METHODS
  Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS Toulouse study were divided into two groups based on vitamin D deficiency (i.e., serum 25-hydroxyvitamin D <10 ng/ml) at baseline. At the end of the 7-year follow-up period, women matching the DSM-IV but not the NINCDS-ADRDA criteria were diagnosed with NAD while those matching the NINCDS-ADRDA criteria were considered to have Alzheimer's disease (AD). Subtle cognitive impairments at baseline, cardiovascular risk factors and Parkinson's disease were used as potential confounders.
  
  
  RESULTS
  NAD was reported in 6 women (82.8 years, 80.6/86.0) after 7 years of follow-up. More NAD were observed in women with vitamin D deficiency (p = 0.023). There was no between-group difference regarding the onset of AD (p = 0.332). We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042). Conversely, vitamin D deficiency was not associated with AD (p = 0.222).
  
  
  CONCLUSIONS
  Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women.
authors.affiliation: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Center, University of Angers, UNAM, Angers, France. CeAnnweiler @ chu-angers.fr
authors.forename: C
authors.initials: C
authors.lastname: Annweiler
authors.forename: Y
authors.initials: Y
authors.lastname: Rolland
authors.forename: A M
authors.initials: AM
authors.lastname: Schott
authors.forename: H
authors.initials: H
authors.lastname: Blain
authors.forename: B
authors.initials: B
authors.lastname: Vellas
authors.forename: O
authors.initials: O
authors.lastname: Beauchet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003704:Dementia / Q000150:complications / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005602:France; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis*; D014815:Vitamins / Q000097:blood
chemical_list: D014815:Vitamins; D014807:Vitamin D