title: [Introduce a new vitro replacement method of skin irritation test].
abstract: A series of new replacement methods of skin irritation test such as EpiSkin, EpiDermSIT (updated) and SkinEthicRHE have been validated by ECVAM. Due to it, animals are protected to the full extent. These provide more methods for biological evaluation of medical devices.
authors.affiliation: SFDA Ji'nan Quality Supervision and Inspection Center for Medical Devices, Biologcial Evaluation of Medical Devices, Key Laboratory of Shandong Province of Ji'nan, 250101. sunlikui2002@126.com
authors.forename: Likui
authors.initials: L
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Hou
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods*; D006801:Humans; D023422:Skin Irritancy Tests / Q000379:methods*