title: Highly enantioselective total synthesis of (+)-isonitramine.
abstract: A new efficient enantioselective synthetic method of (+)-isonitramine is reported. (+)-Isonitramine was obtained in 12 steps (98% ee and 43% overall yield) from δ-valerolactam via enantioselective phase-transfer catalytic alkylation, Dieckman condensation, and diastereoselective reduction as key steps.
authors.affiliation: College of Pharmacy, Inje University, 607 Obang-dong, Gimhae, Gyeongnam 621-749, Korea.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Park
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Suckchang
authors.initials: S
authors.lastname: Hong
authors.forename: Myungmo
authors.initials: M
authors.lastname: Lee
authors.forename: Hyeung-geun
authors.initials: HG
authors.lastname: Park
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010880:Piperidines / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000588:Amines; D010880:Piperidines; D013141:Spiro Compounds