title: Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease.
abstract: The balance between protein and lipid biosynthesis and their eventual degradation is a critical component of cellular health. Autophagy, the catabolic process by which cytoplasmic material becomes degraded in lysosomes, can be induced by various physiological stimuli to maintain cellular homeostasis. Autophagy was for a long time considered a non-selective bulk process, but recent data have shown that unwanted components such as aberrant protein aggregates, dysfunctional organelles and invading pathogens can be selectively eliminated by autophagy. Recently, also intracellular lipid droplets were described as specific autophagic cargo, indicating that autophagy plays a role in lipid metabolism and storage (Singh et al., 2009 [1]). Moreover, over the past several years, it has become increasingly evident that lipids and lipid-modifying enzymes play important roles in the autophagy process itself, both at the level of regulation of autophagy and as membrane constituents required for formation of autophagic vesicles. In this review, we will discuss the interplay between lipids and autophagy, as well as the role of lipid-binding proteins in autophagy. We also comment on the possible implications of this mutual interaction in the context of disease. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
authors.affiliation: Institute of Basic Medical Sciences, University of Oslo, P.B. 1112 Blindern, 0317 Oslo, Norway. helenekn@imbv.uio.no
authors.forename: Helene
authors.initials: H
authors.lastname: Knævelsrud
authors.forename: Anne
authors.initials: A
authors.lastname: Simonsen
mesh_terms: D000818:Animals; D001343:Autophagy; D003593:Cytoplasm / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000172:deficiency / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D050356:Lipid Metabolism; D052439:Lipid Metabolism Disorders / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D010588:Phagosomes / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050556:Fatty Acid-Binding Proteins