title: Application of low dose of FK506 in pancreas transplantation model in Wistar-SD rats.
abstract: OBJECTIVE
  To probe into application of low dose of FK506(Tacrolimus) in pancreas transplantation.
  
  
  METHODS
  Effects of low-dose FK506 (Tacrolimus) in pancreas transplantation with examination of ELISA Electron microscopy and TUNEL by method of random control were studied.
  
  
  RESULTS
  Blood glucose concentration in control group is higher than that in treated group A (FK506) and treated group B (CsA) 7 days after transplantation (p < 0.05). Serum C-peptide and insulin concentrations in control group are less than that in treated group A (FK506) and treated group B (CsA) 7 days after transplantation (p < 0.05). Blood glucose, serum C-peptide and insulin concentrations are same as that in control group, group A (FK506) and group B (CsA) (p > 0.05).There are more apoptotic nuclei in control group than that in treated group A (FK506) and treated group B (CsA) (p < 0.05). There is no significant difference between group A (FK506) and treated group B (CsA) in sum of apoptotic nuclei (p > 0.05). There is no significant difference among treated group A (FK506) and treated group B (CsA) in electron microscopy fields.
  
  
  CONCLUSIONS
  Low-dose FK506 applied in pancreas transplantation could not only be effective for immunosuppressive, but also be safe for islet cells of pancreas.
authors.affiliation: College of Pharmacy, Binzhou Medical University, Yantai City, Shandong Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Shu Xia
authors.initials: SX
authors.lastname: Wang
authors.forename: Qing Yuan
authors.initials: QY
authors.lastname: Li
authors.forename: Hong Shan
authors.initials: HS
authors.lastname: Yin
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000276:immunology; D008297:Male; D016035:Pancreas Transplantation; D011486:Protein C / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D016559:Tacrolimus / Q000494:pharmacology*; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D007328:Insulin; D011486:Protein C; D016572:Cyclosporine; D016559:Tacrolimus