title: Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation.
abstract: OBJECTIVE
  Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate wound healing and rejuvenate aging skin. The current study was conducted to determine whether there are additional effects of PRP combined with fractional laser therapy.
  
  
  METHODS
  Twenty-two Korean women underwent three sessions of fractional laser; 11 were treated with topical application of PRP combined with fractional laser. Evaluations were done at baseline and 1 month after the final treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, and the erythema and melanin index. Biopsies were analyzed using hematoxylin and eosin, Masson-trichrome, and immunohistochemistry for matrix metalloproteinase-1.
  
  
  RESULTS
  PRP combined with fractional laser increased subject satisfaction and skin elasticity and decreased the erythema index. PRP increased the length of the dermoepidermal junction, the amount of collagen, and the number of fibroblasts.
  
  
  CONCLUSIONS
  PRP with fractional laser treatment is a good combination therapy for skin rejuvenation. Keratinocyte and fibroblast proliferation and collagen production can explain the capacity of PRP to increase dermal elasticity.
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Shin
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Sang-Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Nack-In
authors.initials: NI
authors.lastname: Kim
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003357:Cosmetic Techniques; D005260:Female; D006801:Humans; D007834:Lasers; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D012060:Rejuvenation; D056910:Republic of Korea; D015595:Skin Aging