title: A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model.
abstract: Mycotoxins, such as ochratoxin A (OTA), can occur from fungal growth on foods. OTA is considered a possible risk factor for adverse renal effects in humans based on renal tumors in male rats. For risk mitigation, Health Canada proposed maximum limits (MLs) for OTA based largely on a comparative risk assessment conducted by Health Canada (Kuiper-Goodman et al., 2010), in which analytical data of OTA in foods were used to determine the possible impact adopting MLs may have on OTA risks. The EU MLs were used for comparison and resultant risk was determined based on age-sex strata groups. These data were reevaluated here to determine comparative risk on a lifetime basis instead of age strata. Also, as there is scientific disagreement over the mechanism of OTA-induced renal tumors, mechanistic data were revisited. On a lifetime basis, risks associated with dietary exposure were found to be negligible, even without MLs, with dietary exposures to OTA three to four orders of magnitude below the pivotal animal LOAEL and the TD(05). Our review of the mechanistic data supported a threshold-based mechanism as the most plausible. In particular, OTA was negative in genotoxicity assays with the highest specificity and levels of DNA adducts were very low and not typical of genotoxic carcinogens. In conclusion, OTA exposures from Canadian foods do not present a significant cancer risk.
authors.affiliation: Cantox Health Sciences International, An Intertek Company, Mississauga, Ontario, Canada. lois.haighton@intertek.com
authors.forename: Lois A
authors.initials: LA
authors.lastname: Haighton
authors.forename: Barry S
authors.initials: BS
authors.lastname: Lynch
authors.forename: Bernadene A
authors.initials: BA
authors.lastname: Magnuson
authors.forename: Earle R
authors.initials: ER
authors.lastname: Nestmann
mesh_terms: D000818:Animals; D002170:Canada; D002273:Carcinogens / Q000032:analysis / Q000633:toxicity*; D018736:DNA Adducts / Q000378:metabolism / Q000633:toxicity; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D009793:Ochratoxins / Q000032:analysis / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D002273:Carcinogens; D018736:DNA Adducts; D009793:Ochratoxins; C025589:ochratoxin A