title: Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging.
abstract: Multimodal imaging technique is an alternative approach to improve sensitivity of early cancer diagnosis. In this study, highly fluorescent and strong X-ray absorption coefficient gold nanoclusters (Au NCs) are synthesized as dual-modality imaging contrast agents (CAs) for fluorescent and X-ray dual-modality imaging. The experimental results show that the as-prepared Au NCs are well constructed with ultrasmall sizes, reliable fluorescent emission, high computed tomography (CT) value and fine biocompatibility. In vivo imaging results indicate that the obtained Au NCs are capable of fluorescent and X-ray enhanced imaging.
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Tu
authors.forename: Songbing
authors.initials: S
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Juying
authors.initials: J
authors.lastname: Zhou
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
authors.forename: Bingbo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes; D006046:Gold; D053768:Metal Nanoparticles; D014965:X-Rays
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes; D006046:Gold