title: Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.
abstract: Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, USA. donald.stierle@mso.umt.edu
authors.forename: Donald B
authors.initials: DB
authors.lastname: Stierle
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Stierle
authors.forename: Teri
authors.initials: T
authors.lastname: Girtsman
authors.forename: Kyle
authors.initials: K
authors.lastname: McIntyre
authors.forename: Jesse
authors.initials: J
authors.lastname: Nichols
mesh_terms: D061945:Caspase Inhibitors; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis / Q000187:drug effects; D007951:Leukemia, Myeloid; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D061945:Caspase Inhibitors; D053583:Interleukin-1beta; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C571471:berkedrimane A; C571472:berkedrimane B; C437376:drimane