title: Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: a 10-year study in a tertiary hospital of eastern India.
abstract: OBJECTIVE
  The aim was to study the distribution of morphological pattern of benign and malignant ovarian neoplasms in different age groups in eastern India and to determine the likelihood of bilateral involvement in different morphologic subtypes.
  
  
  METHODS
  957 cases of ovarian tumors were studied over a period of 10 years (from January 2001 to December 2010).
  
  
  RESULTS
  Most of the benign tumors occurred between 20 and 40 years of age, while the malignant lesions presented commonly between 41 and 50 years. The most common histological types were serous cystadenoma (29.9%), followed by mature teratoma (15.9%) and mucinous cystadenoma (11.1%). Major proportion of malignant ovarian tumors was contributed by surface epithelial tumors (60.9%). Serous cystadenocarcinoma was the predominant malignant tumor (11.3%). Metastatic tumors were found to involve the bilateral ovaries in 72%, while 49.5% of malignant serous tumors were bilateral. Borderline serous tumors showed bilateral involvement more commonly (27.4%) than borderline mucinous tumors (15.7%). Most of the malignant tumors presented as stage III (60%) or stage II (20%) disease. The overall survival rate was 85% for stage I tumors, 65% for stage II, 30% for stage III and 15.5% for stage IV tumors.
  
  
  CONCLUSIONS
  We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age.
authors.affiliation: Department of Pathology, Medical College, Kolkata, India. santoshkumar@hotmail.com
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Mondal
authors.forename: Ranjana
authors.initials: R
authors.lastname: Banyopadhyay
authors.forename: Dipanwita Roy
authors.initials: DR
authors.lastname: Nag
authors.forename: Suprio
authors.initials: S
authors.lastname: Roychowdhury
authors.forename: Palash Kumar
authors.initials: PK
authors.lastname: Mondal
authors.forename: Swapan Kumar
authors.initials: SK
authors.lastname: Sinha
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*