title: Making sense of low oxygen sensing.
abstract: Plant-specific group VII Ethylene Response Factor (ERF) transcription factors have emerged as pivotal regulators of flooding and low oxygen responses. In rice (Oryza sativa), these proteins regulate contrasting strategies of flooding survival. Recent studies on Arabidopsis thaliana group VII ERFs show they are stabilized under hypoxia but destabilized under oxygen-replete conditions via the N-end rule pathway of targeted proteolysis. Oxygen-dependent sequestration at the plasma membrane maintains at least one of these proteins, RAP2.12, under normoxia. Remarkably, SUB1A, the rice group VII ERF that enables prolonged submergence tolerance, appears to evade oxygen-regulated N-end rule degradation. We propose that the turnover of group VII ERFs is of ecological relevance in wetland species and might be manipulated to improve flood tolerance of crops.
authors.affiliation: Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521-0124, USA. jgardiner@mail.usyd.edu.au
authors.forename: Julia
authors.initials: J
authors.lastname: Bailey-Serres
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukao
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gibbs
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Holdsworth
authors.forename: Seung Cho
authors.initials: SC
authors.lastname: Lee
authors.forename: Francesco
authors.initials: F
authors.lastname: Licausi
authors.forename: Pierdomenico
authors.initials: P
authors.lastname: Perata
authors.forename: Laurentius A C J
authors.initials: LA
authors.lastname: Voesenek
authors.forename: Joost T
authors.initials: JT
authors.lastname: van Dongen
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D055868:Floods; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D013312:Stress, Physiological; D053833:Wetlands
chemical_list: D029681:Arabidopsis Proteins; D010100:Oxygen