title: Study of sexual, urinary, and fecal function in females following restorative proctocolectomy.
abstract: BACKGROUND
  The aim was to investigate quality of life, sexual, fecal, and urinary function in females undergoing restorative proctocolectomy (RPC).
  
  
  METHODS
  A prospective case-control study was performed in two tertiary centers. Controls were females with ulcerative colitis, without a stoma or RPC. Validated questionnaires (SF-36, Female sexual function index, King's questionnaire, and the Wexner scale) were administered in the outpatient setting. Pearson chi(2), t-test, and Mann-Whitney U-tests were used to assess significance.
  
  
  RESULTS
  A total of 255 females were identified and 49% (n = 124) recruited. In all, 109 patients fulfilled the inclusion criteria: 55 (50.5%) inflammatory bowel disease (IBD); 54 (49.5%) RPC. The mean age of RPC patients was 41.8 years (± 12.7 SD) vs. 43.8 years (± 15.8) for IBD (P = 0.491). RPC females with urinary symptoms (urgency, frequency, or incontinence) were 10 years younger than IBD (RPC mean age 37.6 ± 7.3 years vs. IBD 47.4 ± 13.5; P = 0.044). Urgency in fecal function was experienced by more IBD patients (IBD 75.0% vs. RPC 47.9%; P = 0.006), although RPC patients had increased day (P < 0.001) and night bowel frequency (P < 0.001) and were more likely to experience night seepage (P = 0.001). RPC females who had a vaginal delivery (VD) were more likely to have day seepage (P = 0.046) and require pads (P = 0.026) than RPC females who had not undergone VD. There was no significant difference in sexual function.
  
  
  CONCLUSIONS
  RPC may adversely impact urinary function in female patients over time. Bowel frequency, seepage, and pad usage are increased following RPC and function may be worse following VD. RPC does not adversely affect overall sexual function.
authors.affiliation: Department of Biosurgery and Surgical Technology, St Mary's Hospital, Imperial College, London, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Cornish
authors.forename: K
authors.initials: K
authors.lastname: Wooding
authors.forename: E
authors.initials: E
authors.lastname: Tan
authors.forename: R J
authors.initials: RJ
authors.lastname: Nicholls
authors.forename: S K
authors.initials: SK
authors.lastname: Clark
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000601:surgery*; D016737:Proctocolectomy, Restorative; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers; D016482:Urinalysis