title: Integrative systems biology: an attempt to describe a simple weed.
abstract: Genome-scale studies hold great promise for revealing novel plant biology. Because of the complexity of these techniques, numerous considerations need to be made before embarking on a study. Here we focus on the Arabidopsis model system because of the wealth of available genome-scale data. Many approaches are available that provide genome-scale information regarding the state of a given organism (e.g. genomics, epigenomics, transcriptomics, proteomics, metabolomics interactomics, ionomics, phenomics, etc.). Integration of all of these types of data will be necessary for a comprehensive description of Arabidopsis. In this review we propose that 'triangulation' among transcriptomics, proteomics and metabolomics is a meaningful approach for beginning this integrative analysis and uncovering a systems level perspective of Arabidopsis biology.
authors.affiliation: Department of Biology and Duke Center for Systems Biology, Duke University, Durham, NC, USA.
authors.forename: Louisa M
authors.initials: LM
authors.lastname: Liberman
authors.forename: Rosangela
authors.initials: R
authors.lastname: Sozzani
authors.forename: Philip N
authors.initials: PN
authors.lastname: Benfey
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D018745:Genome, Plant / Q000235:genetics; D023281:Genomics / Q000379:methods; D055432:Metabolomics / Q000379:methods; D040901:Proteomics / Q000379:methods; D049490:Systems Biology / Q000379:methods*