title: Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblasts.
abstract: A MeOH extract from the roots of Taraxacum platycarpum has shown significant effects on the proliferation of normal human skin fibroblasts. Chemical analysis of the extract resulted in the isolation of 26 compounds, including eight new triterpenes, one new sesquiterpene glycoside, and seventeen known compounds. The structure of each new compound was established using NMR spectroscopy. Some triterpenes had a significant effect on the proliferation of normal human skin fibroblasts.
authors.affiliation: Institute for Environmental Sciences, University of Shizuoka, 52–1 Yada, Suruga-ku, Shizuoka, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Warashina
authors.forename: Kaoru
authors.initials: K
authors.lastname: Umehara
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D012867:Skin / Q000737:chemistry* / Q000166:cytology; D031205:Taraxacum / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D014315:Triterpenes; D000432:Methanol