title: Use of iontophoresis or phonophoresis for delivering onabotulinumtoxinA in the treatment of palmar hyperidrosis: a report on four cases.
abstract: Idiopathic palmar hyperhidrosis is a common disease that exerts a considerable effect on patients' quality of life. The definitive treatment of this condition (sympathectomy) is associated with some adverse effects and surgical risks. Drugs such as onabotulinumtoxinA can be percutaneously delivered by phonophoresis or by iontophoresis and may be useful in the treatment of hyperhidrosis. In this paper, the authors describe four cases in which an objective and subjective improvement in sweating was seen following 10 daily sessions of phonophoresis or iontophoresis. No adverse effects were reported. The clinical results achieved with treatment were maintained over 16 weeks of follow-up after the end of treatment. Percutaneous drug delivery techniques should be perceived as an option for the treatment of dermatologic conditions.
authors.affiliation: Herminio Ometto University Center, UNIARARAS, Araras, SP, Brazil. patriciacandrade@hotmail.com
authors.forename: Patrícia Cristina
authors.initials: PC
authors.lastname: Andrade
authors.forename: Giovana Pagliari
authors.initials: GP
authors.lastname: Flores
authors.forename: Jéssica de Fátima Moreira
authors.initials: Jde F
authors.lastname: Uscello
authors.forename: Hélio Amante
authors.initials: HA
authors.lastname: Miot
authors.forename: Maria José Misael da Silva
authors.initials: MJ
authors.lastname: Morsoleto
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000523:psychology / Q000628:therapy*; D007478:Iontophoresis; D008297:Male; D009498:Neurotoxins / Q000008:administration & dosage*; D015612:Phonophoresis; D055815:Young Adult
chemical_list: D009498:Neurotoxins; D019274:Botulinum Toxins, Type A