title: [Wheat anaphylaxis or wheat-dependent exercise-induced anaphylaxis caused by use of a soap product which contains hydrolyzed wheat proteins. -a report of 12 cases-].
abstract: BACKGROUND
  Recently, it has become a social problem that hydrolyzed wheat protein in facial soap can induce wheat allergy including wheat-dependent exercise-induced anaphylaxis (WDEIA). We described the clinical characteristics of the patients related.
  
  
  METHODS
  We collected 12 cases who had had a medical examination from January to October in 2010.
  
  
  RESULTS
  All the patients were female and mean age was 36.0± 9.9 years. All of them had had no prior symptoms history of wheat allergy, they gradually developed wheat anaphylaxis or WDEIA in an average of 2 years after they started to use a soap product in question which contains hydrolyzed wheat proteins. Most patients suffered immediate contact allergic reactions after or at the time of washing their face with the soap product. 10 of 12 patients showed a low level of IgE to CAP-recombinant ω-5-gliadin. Episodes of anaphylaxis were prevented by avoiding both intake of wheat-containing foods and usage of the soap product.
  
  
  CONCLUSIONS
  We concluded that their wheat anaphylaxis is likely to be caused by epicutaneous sensitization of the hydrolyzed wheat proteins in the soap product. It was important that physicians should know the possibility of sensitization from non-dietary antigen.
authors.affiliation: Department of Dermatology, National Fukuoka Hospital.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Reiko
authors.initials: R
authors.lastname: Kishikawa
authors.forename: Haruko
authors.initials: H
authors.lastname: Nishie
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Terufumi
authors.initials: T
authors.lastname: Shimoda
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Sankei
authors.initials: S
authors.lastname: Nishima
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D015444:Exercise; D005260:Female; D006801:Humans; D006868:Hydrolysis; D008875:Middle Aged; D012915:Soaps / Q000009:adverse effects*; D014908:Triticum / Q000276:immunology*; D021182:Wheat Hypersensitivity / Q000276:immunology*
chemical_list: D012915:Soaps