title: The role of the E2F transcription factor family in UV-induced apoptosis.
abstract: The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
authors.affiliation: Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia. m.rethinam@uq.edu.au
authors.forename: Mehlika
authors.initials: M
authors.lastname: Hazar-Rethinam
authors.forename: Liliana
authors.initials: L
authors.lastname: Endo-Munoz
authors.forename: Orla
authors.initials: O
authors.lastname: Gannon
authors.forename: Nicholas
authors.initials: N
authors.lastname: Saunders
mesh_terms: D000818:Animals; D017209:Apoptosis; D050684:E2F Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D050684:E2F Transcription Factors