title: Effect of orange oil on the oral absorption of enrofloxacin in rats.
abstract: This study was conducted to evaluate the oral absorption of enrofloxacin (ENFX) in rats when administered with orange oil or its main component, limonene. Compared with the group administered ENFX alone, the ENFX + limonene group did not show any significant difference in the absorption of ENFX, whereas the extent and rate of absorption of ENFX were significantly decreased in the ENFX + orange oil group (C(max), -43%; T(max), 129%). In addition, t(1/2λz) and MRT of ENFX were prolonged by the concomitant administration of orange oil. The AUCs of ENFX were not affected in the ENFX + orange oil group. These results suggest that decreased oral absorption could reduce the efficacy of ENFX therapy in animals.
authors.affiliation: B&C Biopharm, Suwon, Gyeonggi, South Korea.
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: Myoung-Seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Youn-Hwan
authors.initials: YH
authors.lastname: Hwang
authors.forename: In-Bae
authors.initials: IB
authors.lastname: Song
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Kim
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
mesh_terms: D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D053138:Cyclohexenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004347:Drug Interactions; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000077222:Limonene; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013729:Terpenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D053138:Cyclohexenes; D004338:Drug Combinations; D024841:Fluoroquinolones; D010938:Plant Oils; D013729:Terpenes; D000077422:Enrofloxacin; D000077222:Limonene; C087245:orange oil