title: Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.
abstract: There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDGF-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.
authors.affiliation: Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. maria.bjorkqvist@med.lu.se
authors.forename: Maria
authors.initials: M
authors.lastname: Björkqvist
authors.forename: Mattias
authors.initials: M
authors.lastname: Ohlsson
authors.forename: Lennart
authors.initials: L
authors.lastname: Minthon
authors.forename: Oskar
authors.initials: O
authors.lastname: Hansson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis*; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood*; D019742:Chemokines, CC / Q000097:blood; D003704:Dementia / Q000097:blood / Q000175:diagnosis; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008875:Middle Aged; D011237:Predictive Value of Tests; D020574:Proto-Oncogene Proteins c-sis / Q000097:blood; D012372:ROC Curve
chemical_list: D015415:Biomarkers; C108814:CCL15 protein, human; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D004815:Epidermal Growth Factor