title: δ¹⁵N enrichment suggests possible source for halogenated 1'-methyl-1,2'-bipyrroles (MBPs).
abstract: Polyhalogenated 1'-methyl-1,2'-bipyrroles are natural products that biomagnify into upper trophic levels of marine food webs. Here we demonstrate that they are unusually enriched in (15)N (δ(15)N from +19.3‰ to +28.1‰) relative to other biosynthetic organic compounds measured to date and the mammals from which the compounds were isolated. We argue the (15)N enrichment likely stems from enriched precursors and/or fractionation during biosynthesis and is not from MBP degradation. We also consider possible sources of MBPs in light of these results.
authors.affiliation: Department of Chemistry, Colgate University, Hamilton, New York 13346, United States. kpangallo@colgate.edu
authors.forename: Kristin C
authors.initials: KC
authors.lastname: Pangallo
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Reddy
authors.forename: Matthew
authors.initials: M
authors.lastname: Poyton
authors.forename: Jakov
authors.initials: J
authors.lastname: Bolotin
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Hofstetter
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000818:Animals; D001688:Biological Products / Q000032:analysis; D004289:Dolphins; D004784:Environmental Monitoring; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000032:analysis*; D008297:Male; D008404:Massachusetts; D009587:Nitrogen Isotopes / Q000032:analysis*; D011758:Pyrroles / Q000032:analysis*
chemical_list: D001688:Biological Products; D006846:Hydrocarbons, Halogenated; D009587:Nitrogen Isotopes; D011758:Pyrroles