title: Models of muscle pain: carrageenan model and acidic saline model.
abstract: Carrageenan or acidic saline injected unilaterally into the gastrocnemius muscle or triceps muscle produces a robust and long-lasting hyperalgesia in rats and mice, which is reversible with systemic administration of opioid or anti-inflammatory drugs. This unit describes detailed protocols for inducing and measuring hyperalgesia, and provides information on validation of these models. These models are useful for assessing new compounds for their analgesic activity in muscular pain.
authors.affiliation: University of Iowa, Iowa City, Iowa, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Radhakrishnan
authors.forename: Marie K Hoeger
authors.initials: MK
authors.lastname: Bement
authors.forename: David
authors.initials: D
authors.lastname: Skyba
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Sluka
authors.forename: Lois J
authors.initials: LJ
authors.lastname: Kehl
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000822:Animal Husbandry; D000818:Animals; D002351:Carrageenan; D003625:Data Collection; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000502:physiology; D059352:Musculoskeletal Pain / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012965:Sodium Chloride; D014110:Touch
chemical_list: D000700:Analgesics; D012965:Sodium Chloride; D002351:Carrageenan