title: Polymorphisms of platelet ADP receptor P2RY12 in the risk of venous thromboembolism in the Korean population.
abstract: Although it was thought that platelets did not play a significant role in the pathogenesis of venous thromboembolism (VTE), several studies demonstrated that a marked activation of platelets occurs in patients with VTE. We carried out a case-control study to investigate the effect of the T744C P2RY12 polymorphism on the risk of VTE in the Korean population. We enrolled 154 consecutive patients with VTE and 415 healthy controls. Genotype frequencies for patients with TT, TC, and CC were 71.4%, 24.7%, and 3.9% and in the controls, 68.2%, 30.1%, and 1.7%, respectively. T744C P2RY12 polymorphism did not significantly affect the risk of VTE. Our study shows that T744C P2RY12 polymorphism did not significantly affect the risk of VTE in the Korean population.
authors.affiliation: Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.
authors.forename: Moon Ju
authors.initials: MJ
authors.lastname: Jang
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Min
authors.forename: Jisu
authors.initials: J
authors.lastname: Oh
authors.forename: So Young
authors.initials: SY
authors.lastname: Chong
authors.forename: Seonyang
authors.initials: S
authors.lastname: Park
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Yun-Choi
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D058925:Receptors, Purinergic P2Y12 / Q000235:genetics*; D056910:Republic of Korea; D012307:Risk Factors; D013923:Thromboembolism / Q000235:genetics*
chemical_list: C548576:P2RY12 protein, human; D058925:Receptors, Purinergic P2Y12