title: Comment on 5-HT and mechanisms of defence.
abstract: The paper by Deakin and Graeff is a thought-provoking tour-de-force. They propose a comprehensive theory about serotonin (5-hydroxytryptamine; 5-HT) and anxiety, covering much of the same literature which we previously reviewed (Kahn et al., 1988a). We certainly agree that there seems to be an association between 5-HT function and anxiety, but we take issue with several important aspects of Deakin and Graeff's hypothesis. We limit our comments to their discussion of anxiety and panic.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, USA.
authors.forename: S
authors.initials: S
authors.lastname: Wetzler
authors.forename: G M
authors.initials: GM
authors.lastname: Asnis
authors.forename: H M
authors.initials: HM
authors.lastname: van Praag