title: [Importance of proliferative potential (as the ratio of a proliferative cells number and duration of mitosis) in diagnoses of malignant degree and prognosis of adrenocortical cancer].
abstract: The aim of research has been the estimation of a proliferative potential as simultaneous detection of a proliferative cells number (Ki-67 index) and duration of mitosis (nucleolar argyrophilic protein expression--B23/nucleophosmin and C23/nucleolin) at patients with adrenocortical cancer. In according to lifetime of patients after operation 2 groups had been sorted out. The first one included patients surviving 56.12 months, the second one--9.25 months. We've found out that different aspects of tumor diagnosis as well distinction of benignant or malignant tumor growth, a malignant degree of tumors, a prognostic criteria of illness, survival of patients etc. must be characterized by total research both a proliferative cells fraction (Ki-67 index) and a rate of mitosis (expressions of B23/nucleophosmin and C23/nucleolin).
authors.forename: N T
authors.initials: NT
authors.lastname: Raĭkhlin
authors.forename: I A
authors.initials: IA
authors.lastname: Bukaeva
authors.forename: A V
authors.initials: AV
authors.lastname: Filimoniuk
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: N A
authors.initials: NA
authors.lastname: Probatova
authors.forename: A I
authors.initials: AI
authors.lastname: Pavlovskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Shabanov
authors.forename: M V
authors.initials: MV
authors.lastname: Ponomareva
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000378:metabolism / Q000401:mortality / Q000601:surgery / Q000648:ultrastructure; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008938:Mitosis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins