title: Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes.
abstract: Measles infection and vaccine response are complex biological processes that involve both viral and host genetic factors. We have previously investigated the influence of genetic polymorphisms on vaccine immune response, including measles vaccines, and have shown that polymorphisms in HLA, cytokine, cytokine receptor, and innate immune response genes are associated with variation in vaccine response but do not account for all of the inter-individual variance seen in vaccinated populations. In the current study we report the findings of a multigenic analysis of measles vaccine immunity, indicating a role for the measles virus receptor CD46, innate pattern-recognition receptors (DDX58, TLR2, 4, 5, 7 and 8) and intracellular signaling intermediates (MAP3K7, NFKBIA), and key antiviral molecules (VISA, OAS2, MX1, PKR) as well as cytokines (IFNA1, IL4, IL6, IL8, IL12B) and cytokine receptor genes (IL2RB, IL6R, IL8RA) in the genetic control of both humoral and cellular immune responses. This multivariate approach provided additional insights into the genetic control of measles vaccine responses over and above the information gained by our previous univariate SNP association analyses.
authors.affiliation: Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kennedy
authors.forename: Inna G
authors.initials: IG
authors.lastname: Ovsyannikova
authors.forename: Iana H
authors.initials: IH
authors.lastname: Haralambieva
authors.forename: Megan M
authors.initials: MM
authors.lastname: O'Byrne
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jacobson
authors.forename: V Shane
authors.initials: VS
authors.lastname: Pankratz
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
mesh_terms: D000293:Adolescent; D002648:Child; D016207:Cytokines / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D008297:Male; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D051916:Membrane Cofactor Protein / Q000235:genetics*; D051193:Toll-Like Receptors / Q000235:genetics*; D055815:Young Adult
chemical_list: C497857:CD46 protein, human; D016207:Cytokines; D008458:Measles Vaccine; D051916:Membrane Cofactor Protein; D051193:Toll-Like Receptors