title: HIV and asthma, is there an association?
abstract: OBJECTIVE
  To evaluate whether asthma and airway hyper-responsiveness are associated with HIV infection.
  
  
  METHODS
  We reviewed the literature on HIV-associated pulmonary diseases, pulmonary symptoms, and immune changes which may play a role in asthma. The information was analyzed comparing the pre-HAART era to the post-HAART era data.
  
  
  RESULTS
  HIV-seropositive individuals commonly experience respiratory complaints yet it is unclear if the frequency of these complaints have changed with the initiation of HAART. Changes in pulmonary function testing and serum IgE are seen with HIV infection even in the post-HAART era. An increased prevalence of asthma among HIV-seropositive children treated with HAART has been reported.
  
  
  CONCLUSIONS
  The spectrum of HIV-associated pulmonary disease has changed with the introduction of HAART. Current data is limited to determine if asthma and airway hyper-responsiveness are more common among HIV-seropositive individuals treated with HAART.
authors.affiliation: The Ohio State University, Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart & Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA. Jessica.Kynyk@osumc.edu
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Kynyk
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Parsons
authors.forename: Michael F
authors.initials: MF
authors.lastname: Para
authors.forename: Susan L
authors.initials: SL
authors.lastname: Koletar
authors.forename: Philip T
authors.initials: PT
authors.lastname: Diaz
authors.forename: John G
authors.initials: JG
authors.lastname: Mastronarde
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000821:virology*; D016535:Bronchial Hyperreactivity / Q000821:virology; D016207:Cytokines / Q000097:blood; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000821:virology
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E