title: CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients.
abstract: OBJECTIVE
  The CYBA C242T polymorphism has been associated with cardiovascular phenotypes such as hypertension and atherosclerosis, but available data are conflicting. This report investigated the impact of this variant on hypertension and metabolic determinants of cardiovascular risk in a large Brazilian sample.
  
  
  METHODS
  We cross-sectionally evaluated 1856 subjects (826 normotensive subjects and 1030 hypertensive patients) by clinical history, anthropometry, laboratory analysis and genotyping of the CYBA C242T polymorphism.
  
  
  RESULTS
  Genotype frequencies in the whole population were consistent with the Hardy-Weinberg equilibrium and genotype distributions were not different between hypertensive and normotensive subjects. Hypertensive patients with the CC genotype presented lower fasting plasma glucose levels (5.9 ± 0.1 vs. 6.2 ± 0.1 mmol/l, P = 0.020) and waist circumference (94.5 ± 0.6 vs. 96.3 ± 0.6 cm, P = 0.028) than CT + TT ones. Similarly, the prevalence of diabetes mellitus and obesity was also lower in hypertensive patients carrying the CC genotype (16% vs. 21%, P = 0.041; 36% vs. 43%, P = 0.029, respectively). In addition, multiple and logistic regression analysis demonstrated that the CYBA C242T polymorphism was associated with glucose levels, waist circumference, obesity and diabetes mellitus in hypertensive patients independently of potential confounders. Conversely, in normotensive subjects, no significant difference in studied variables was detected between the genotype groups.
  
  
  CONCLUSIONS
  These data suggest that the T allele of the CYBA C242T polymorphism may be used as a marker for adverse metabolic features in Brazilian subjects with systemic hypertension.
authors.affiliation: Department of Internal Medicine, University of Campinas, Campinas, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Schreiber
authors.forename: M C
authors.initials: MC
authors.lastname: Ferreira-Sae
authors.forename: A C
authors.initials: AC
authors.lastname: Tucunduva
authors.forename: J G
authors.initials: JG
authors.lastname: Mill
authors.forename: Felipe O
authors.initials: FO
authors.lastname: Costa
authors.forename: J E
authors.initials: JE
authors.lastname: Krieger
authors.forename: K G
authors.initials: KG
authors.lastname: Franchini
authors.forename: A C
authors.initials: AC
authors.lastname: Pereira
authors.forename: W
authors.initials: W
authors.lastname: Nadruz
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D003545:Cysteine; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013912:Threonine
chemical_list: D013912:Threonine; D019255:NADPH Oxidases; C086986:CYBA protein, human; D003545:Cysteine