title: Evaluation of the value of p53 protein expression in the extra-capsular extension of prostate cancer.
abstract: OBJECTIVE
  The objective of this study is to identify the nuclear expression of the p53 protein in prostate cancer and to determine its relationship with clinico-pathological variables.
  
  
  METHODS
  The research included 83 patients, 43 of whom are patients with prostate cancer who underwent radical prostatectomy and a control group of 40 patients with benign hyperplasia of the prostate in whom a transurethral resection or a transvesical prostatectomy was undertaken. In all cases the nuclear expression of p53 protein was evaluated. A hystopatological evaluation of the tumour characteristics and the data of the local progression of the cancer were undertaken in the research group.
  
  
  RESULTS
  The results show that the expression of the p53 protein does not have an important correlation with the preoperative PSA, but that it is in direct correlation with the malign potential of the cancer (Gleason score, Gleason sum, primary tumour) and with the features of the disease (metastatic lymph nodes, stage of the disease).
  
  
  CONCLUSIONS
  p53 protein could be used as a valid biomarker in determining the malignant potential of the tumour and the prognosis of the disease. There is no practical use in predicting the extraprostatic extension.
authors.affiliation: University Urology Clinic, Medical Faculty, Ss Cyril and Methodius University, Skopje, R. Macedonia.
authors.forename: S
authors.initials: S
authors.lastname: Saidi
authors.forename: V
authors.initials: V
authors.lastname: Georgiev
authors.forename: S
authors.initials: S
authors.lastname: Stavridis
authors.forename: M
authors.initials: M
authors.lastname: Penev
authors.forename: O
authors.initials: O
authors.lastname: Stankov
authors.forename: S
authors.initials: S
authors.lastname: Dohcev
authors.forename: S
authors.initials: S
authors.lastname: Banev
authors.forename: D
authors.initials: D
authors.lastname: Danilovski
authors.forename: O
authors.initials: O
authors.lastname: Ivanovski
authors.forename: Z
authors.initials: Z
authors.lastname: Popov
mesh_terms: D000368:Aged; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D019990:Perioperative Care / Q000379:methods; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology; D018843:Republic of North Macedonia; D012189:Retrospective Studies; D013223:Statistics as Topic; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D017430:Prostate-Specific Antigen