title: [Interaction between the single-nucleotide polymorphism of DNA repair gene hOGG1 and HBV infection and its susceptibility to hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the relationship between the single-nucleotide polymorphism of DNA repair gene hOGG1 and the susceptibility to hepatocellular carcinoma (HCC), and the interaction between hOGG1 and environmental risk factors in a hepatocarcinoma high risk area.
  
  
  METHODS
  This hospital-based case control study was conducted in 500 HCC patients and 507 controls. The polymorphism of hOGG1-Ser326Cys was genotyped by a real time polymerase chain reaction-TaqMan MGB.
  
  
  RESULTS
  The allele mutation frequencies of hOGG1-326Cys in the case group and control group were 24.60% and 10.75% respectively (P < 0.05). The genotype frequencies of hOGG1 Ser/Ser, Ser/Cys, Cys/Cys were 71.40%, 8.00% and 20.6% in the case group, and were 84.22%, 10.06% and 5.72% in the control group respectively (P < 0.05). Compared with the wild hOGG1-326Ser/Ser genotype, the mutant hOGG1 allele increased the risk of HCC (OR = 2.14, 95% CI: 1.57 -2.91). The hOGG1-326Cys allele was the major determinant factor for the risk of HCC. The interaction of hOGG1-326Cys allele with chronic HBV infection (OR = 38.15, 95% CI: 18.90 - 61.71) tremendously increased the risk of HCC. The synergy index of multiplicative interaction is 0.61 and the synergy index of additive interaction is 1.31.
  
  
  CONCLUSIONS
  The hOGG1-326Cys allele may contribute to the risk of HCC. The synergistic interaction between hOGG1-326Cys allele and chronic HBV infection might modify the risk of HCC. Further studies with larger sample size are warranted to confirm these findings.
authors.affiliation: School of Public Health, Taishan Medical College, Tai' an 271000, China. lji@tsmc.edu.cn
authors.forename: Long
authors.initials: L
authors.lastname: Ji
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zeng
authors.forename: Longman
authors.initials: L
authors.lastname: Li
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Qiu
authors.forename: Sixia
authors.initials: S
authors.lastname: Chen
authors.forename: Hongping
authors.initials: H
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000821:virology; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human