title: Dementia is associated with insulin resistance in patients with Parkinson's disease.
abstract: BACKGROUND
  Parkinson's disease is a neurodegenerative disorder involving the basal ganglia. Type-2 Diabetes Mellitus is an important risk factor for Alzheimer disease and vascular dementia. However, the association between Parkinson's disease and Diabetes Mellitus is controversial.
  
  
  OBJECTIVE
  To investigate glucose metabolism abnormalities in 110 Parkinson's disease patients with and without dementia.
  
  
  METHODS
  We evaluated Insulin Resistance, glucose and insulin levels after a 2-h-oral-glucose-tolerance-test in 53 Parkinson's disease with dementia and 57 with Parkinson's disease without dementia, with normal fasting glucose.
  
  
  RESULTS
  BMI, waist circumference, fasting glucose and insulin values, HbA1c, triglycerides, blood lipid profile, depression rating, educational levels, levodopa-dosage and antipsychotic use were similar in both groups. Disease duration and motor impairment were higher in patients with Parkinson's disease and dementia group. After 2-h-oral-glucose-tolerance-test, the prevalence of glucose metabolism abnormalities was significantly higher in group with Parkinson's disease and dementia group (p=0.03). The insulin resistance was present in 62% patients with Parkinson's disease with dementia, of whom 30% had also impaired glucose tolerance, 5,6% newly diagnosed Diabetes Mellitus and 26% only Insulin Resistance. These percentages were significantly higher in group with Parkinson's disease and dementia, also after adjustment for disease duration and motor disability.
  
  
  CONCLUSIONS
  Our study suggests that PD patients with dementia are two times more likely to have insulin resistance than patients with PD.
authors.affiliation: Department of Neuroscience, S. Giovanni di Dio Hospital, Via Largo Bologna, 88900, Crotone, Italy. nico_bosco@libero.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Bosco
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Plastino
authors.forename: Dario
authors.initials: D
authors.lastname: Cristiano
authors.forename: Carmela
authors.initials: C
authors.lastname: Colica
authors.forename: Caterina
authors.initials: C
authors.lastname: Ermio
authors.forename: Matteo
authors.initials: M
authors.lastname: De Bartolo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mungari
authors.forename: Giulia
authors.initials: G
authors.lastname: Fonte
authors.forename: Domenico
authors.initials: D
authors.lastname: Consoli
authors.forename: Arturo
authors.initials: A
authors.lastname: Consoli
authors.forename: Antonietta
authors.initials: A
authors.lastname: Fava
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003704:Dementia / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose