title: Polyvinyl alcohol-pectin cryogel films for controlled release of enrofloxacin.
abstract: The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA-P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA-P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.
authors.affiliation: Institute of Applied Biotechnology-CINDEFI, CONICET-CCT La Plata, School of Sciences, University of La Plata, 1900 Plata, Argentina.
authors.forename: Yanina N
authors.initials: YN
authors.lastname: Martinez
authors.forename: Lucrecia
authors.initials: L
authors.lastname: Piñuel
authors.forename: Guillermo R
authors.initials: GR
authors.lastname: Castro
authors.forename: Javier D
authors.initials: JD
authors.lastname: Breccia
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D059985:Cryogels / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000737:chemistry*; D009994:Osmolar Concentration; D010368:Pectins / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D059985:Cryogels; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D024841:Fluoroquinolones; D000077422:Enrofloxacin; D010368:Pectins; D011142:Polyvinyl Alcohol