title: Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
abstract: Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
authors.affiliation: Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029, India. jatinderkatyal.aiims@gmail.com
authors.forename: Jatinder
authors.initials: J
authors.lastname: Katyal
authors.forename: Vikas
authors.initials: V
authors.lastname: Sarangal
authors.forename: Yogendra Kumar
authors.initials: YK
authors.lastname: Gupta
mesh_terms: D029023:Acorus / Q000737:chemistry*; D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000494:pharmacology*; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000494:pharmacology*; D003292:Convulsants / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014018:Tissue Distribution; D014635:Valproic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D010936:Plant Extracts; D002220:Carbamazepine; D014635:Valproic Acid; D010433:Pentylenetetrazole