title: [Intracranial hypertension - Therapeutic options].
abstract: Increased intracranial pressure can be the result of different intracranial pathologies. Sustained intracranial pressure above 20-25 mmHg may cause secondary brain injury by impaired cerebral perfusion or direct pressure with neuronal injury, with in consequence deterioration of neurological outcome. A main cause of critically increased intracranial pressure is traumatic brain injury. Most treatment strategies for increased intracranial pressure were developed and studied on these patients. Most of them were transferred to other pathologies with increased intracranial pressure.Treatment is based on general measures, which can be escalated for medical and surgical options in case of failure to sufficiently decrease intracranial pressure below the established threshold. Despite its enormous medical and socio-economical relevance, the evidence for most treatment strategies of intracranial hypertension, though published in guidelines, is weak.
authors.affiliation: Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin (Interdisziplinäre Neurointensivstation), Charite-Universitätsmedizin Berlin. christoph.rosenthal@charite.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Rosenthal
authors.forename: Stefan
authors.initials: S
authors.lastname: Wolf
authors.forename: Steffen
authors.initials: S
authors.lastname: Weber-Carstens
authors.forename: Farid
authors.initials: F
authors.lastname: Salih
mesh_terms: D019299:Decompression, Surgical / Q000379:methods*; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000628:therapy*