title: Epigenetics in nucleotide repeat expansion disorders.
abstract: Over the past 20 years, nucleotide repeat expansion disorders have informed our broader understanding of neurodevelopmental and neurodegenerative disease. This is especially true with regard to the contributions of epigenetic mechanisms to neurologic disease pathogenesis. In this review, the authors describe a few of the myriad ways in which epigenetic processes underlie aspects of repeat expansion disorder pathophysiology and discuss how therapies targeted at epigenetic modulation hold promise for many of these disorders.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Peter K
authors.initials: PK
authors.lastname: Todd
mesh_terms: D002843:Chromatin / Q000378:metabolism; D019175:DNA Methylation / Q000502:physiology; D042622:DNA Repeat Expansion / Q000502:physiology*; D044127:Epigenesis, Genetic; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D009223:Myotonic Dystrophy / Q000235:genetics*; D010455:Peptides / Q000235:genetics; D020754:Spinocerebellar Ataxias / Q000235:genetics*; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics
chemical_list: D002843:Chromatin; D010455:Peptides; D050826:Suppressor of Cytokine Signaling Proteins; C097188:polyglutamine