title: [Development of bioanalytical techniques using micro- and nanostructures for medical applications].
abstract: Micro- and nanobiodevices, which utilize micro- and nanospace corresponding in size to various biomolecules, are currently accelerating research on medical diagnosis and regenerative medicine. Moreover, novel analytical techniques beyond the past limitations are developed utilizing micro- and nanospace and are achieving an innovation from basic research to clinical diagnosis and therapy. We have developed nanopillar and nanowall array structures for a single molecule measurement and separation sciences, and then, demonstrated unique analytical techniques specific to a precisely defined nanospace. Physicochemical and biological approaches were adopted to understand nanofluidics in these nanospaces and interesting phenomena were found. We are also trying to transfer these micro- and nanodevices to clinical practices. Some examples such as a blood plasma separation device, a therapeutic drug monitoring device, an immuno-pillar device for high-speed and high-sensitivity cancer and disease markers are described in this paper.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, Japan. kaji.noritada@g.mbox.nagoya-u.ac.jp
authors.forename: Noritada
authors.initials: N
authors.lastname: Kaji
mesh_terms: D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D007118:Immunoassay; D025202:Molecular Diagnostic Techniques / Q000379:methods; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D044968:Regenerative Medicine