title: Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.
abstract: OBJECTIVE
  Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odds ratios and compute P values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method.
  
  
  RESULTS
  We did not find a significant association between rs1562430, rs1447295, or rs6983267 and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P = .003, and 12 other SNPs were associated with PTC risk at P < .05. However, no SNPs remained significant after FDR correction.
  
  
  CONCLUSIONS
  Our findings do not support a strong association between SNPs in the 8q24 chromosomal region and risk of sporadic PTC, but several SNPs with small effects might exist.
authors.affiliation: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. netagil@mail.nih.gov
authors.forename: Gila
authors.initials: G
authors.lastname: Neta
authors.forename: Chu-Ling
authors.initials: CL
authors.lastname: Yu
authors.forename: Alina
authors.initials: A
authors.lastname: Brenner
authors.forename: Fangyi
authors.initials: F
authors.lastname: Gu
authors.forename: Amy
authors.initials: A
authors.lastname: Hutchinson
authors.forename: Ruth
authors.initials: R
authors.lastname: Pfeiffer
authors.forename: Erich M
authors.initials: EM
authors.lastname: Sturgis
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Martha S
authors.initials: MS
authors.lastname: Linet
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Alexander
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.forename: Alice J
authors.initials: AJ
authors.lastname: Sigurdson
mesh_terms: D000328:Adult; D002277:Carcinoma; D002291:Carcinoma, Papillary; D002898:Chromosomes, Human, Pair 8; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014481:United States / Q000453:epidemiology
chemical_list: D004273:DNA, Neoplasm