title: Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae).
abstract: BACKGROUND
  Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil).
  
  
  OBJECTIVE
  To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use.
  
  
  METHODS
  Anti-inflammatory, antihyperalgesic and antiulcer activities were evaluated in Wistar rats, a Hippocratic screening was performed in Swiss mice to evaluate the toxic effects, and antiplatelet evaluation was performed in human platelet rich plasma assay. Additionally, antioxidant activity was evaluated by superoxide radical scavenging method and β-carotene bleaching test.
  
  
  RESULTS
  Anti-inflammatory, antihyperalgesic and gastroprotective activities were observed in rats treated orally with different doses of BJEA. While signals of toxicity were observed in the mice treated with a very high dose of extract (5000mg/kg), no death occurred. BJEA also showed expressive antiplatelet and antioxidant activities in vitro.
  
  
  CONCLUSIONS
  According to our results, it was concluded that stem bark of Byrsonima japurensis has significant and safe anti-inflammatory activity, which is closely related with their potent antioxidant activity, supporting the folk medicinal use of this species.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, 330, Aparecida, 69910-300, Manaus, Amazonas, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Guilhon-Simplicio
authors.forename: Carlos Cleomir de Souza
authors.initials: CC
authors.lastname: Pinheiro
authors.forename: Gabrielly Galdino
authors.initials: GG
authors.lastname: Conrado
authors.forename: Gleyce Dos Santos
authors.initials: Gdos S
authors.lastname: Barbosa
authors.forename: Pierre Alexandre Dos
authors.initials: PA
authors.lastname: Santos
authors.forename: Maria de Meneses
authors.initials: Mde M
authors.lastname: Pereira
authors.forename: Emerson Silva
authors.initials: ES
authors.lastname: Lima
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001938:Brazil; D002351:Carrageenan; D004487:Edema / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D029581:Malpighiaceae / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000517:prevention & control; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D018547:Plant Stems; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D013481:Superoxides / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D019207:beta Carotene; D013481:Superoxides; D002351:Carrageenan