title: Examining host-microbial interactions through the lens of NOD: From plants to mammals.
abstract: Nod-like receptors (NLRs) for detecting microbial invaders are features of many plant and animal families. Although broadly similar in form and function, intimate co-evolutionary events with environmental microbes have shaped specific classes of NLRs in different types of hosts. Details of the roles of different NLRs in signaling cellular immune responses to invading microbes are only beginning to emerge. This review will discuss the current understanding of NLRs in plants, invertebrates, and mammals, with emphasis on their role in regulating NF-κB and inflammasome activity in mammals.
authors.affiliation: Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. susan.robertson@utoronto.ca
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Robertson
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Rubino
authors.forename: Kaoru
authors.initials: K
authors.lastname: Geddes
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Philpott
mesh_terms: D000818:Animals; D018628:Gene Dosage; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D053472:Nod Signaling Adaptor Proteins / Q000378:metabolism*; D010944:Plants / Q000378:metabolism / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D053472:Nod Signaling Adaptor Proteins