title: Resveratrol reduces vacuous chewing movements induced by acute treatment with fluphenazine.
abstract: Treatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the possible neuroprotective effects of resveratrol, a polyphenol compound contained in red grapes and red wine, in an animal model of orofacial dyskinesia (OD) induced by acute treatment with fluphenazine. Adult male rats were treated during 3 weeks with fluphenazine enantate (25 mg/kg, i.m., single administration) and/or resveratrol (1 mg/kg, s.c., 3 times a week). Vacuous chewing movements (VCMs), locomotor and exploratory performance were evaluated. Fluphenazine treatment produced VCM in 70% of rats and the concomitant treatment with resveratrol decreased the prevalence to 30%, but did not modify the intensity of VCMs. Furthermore, the fluphenazine administration reduced the locomotor and exploratory activity of animals in the open field test. Resveratrol co-treatment was able to protect the reduction of both parameters. Taken together, our data suggest that resveratrol could be considered a potential neuroprotective agent by reducing motor disorders induced by fluphenazine treatment.
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, Brazil.
authors.forename: Alcindo
authors.initials: A
authors.lastname: Busanello
authors.forename: Luis R
authors.initials: LR
authors.lastname: Peroza
authors.forename: Caroline
authors.initials: C
authors.lastname: Wagner
authors.forename: Jéssie H
authors.initials: JH
authors.lastname: Sudati
authors.forename: Romaiana P
authors.initials: RP
authors.lastname: Pereira
authors.forename: Alessandro de S
authors.initials: Ade S
authors.lastname: Prestes
authors.forename: João B T
authors.initials: JB
authors.lastname: Rocha
authors.forename: Roselei
authors.initials: R
authors.lastname: Fachinetto
authors.forename: Nilda B V
authors.initials: NB
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D005476:Fluphenazine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D008409:Mastication / Q000187:drug effects*; D009069:Movement Disorders / Q000503:physiopathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D013267:Stilbenes; D000077185:Resveratrol; D005476:Fluphenazine