title: Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory state of the GI tract of unknown etiology. Classically, tissue injury in IBD is thought to be primarily mediated by Th1 cells in Crohn's disease or Th2 cells in ulcerative colitis. The discoveries of new subsets of T-helper cells, especially Th17 cells, have revolutionized our understanding of the disease immunopathology. Th17 cells seem to affect both innate and adaptive immune responses by the release of regulatory cytokines. Understanding the role of Th17 cells in IBD pathogenesis and targeting their regulatory cytokines may provide potential therapeutic approaches for the treatment of IBD in the future.
authors.affiliation: Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati, 231 Albert B. Sabin Way, MSB 6466, PO Box 670595, Cincinnati, OH 45267-0595, USA. razaai@ucmail.uc.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Raza
authors.forename: Wajeeha
authors.initials: W
authors.lastname: Yousaf
authors.forename: Ralph
authors.initials: R
authors.lastname: Giannella
authors.forename: Mohamed Tarek
authors.initials: MT
authors.lastname: Shata
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D004198:Disease Susceptibility / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D018417:Th1 Cells / Q000276:immunology / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology / Q000473:pathology