title: Improved outcomes in buccal squamous cell carcinoma.
abstract: BACKGROUND
  The treatment results of buccal squamous cell carcinoma before and after 2002 were compared.
  
  
  METHODS
  Two hundred forty-five patients with buccal cancer who underwent curative treatment were retrospectively reviewed.
  
  
  RESULTS
  The 5-year overall survival rate was 30.0% before 2002 and 53.5% after 2002 (p = .004). On multivariate analysis, T classification, surgical margins, and treatment modality significantly affected overall survival, and N classification and histologic grade had trends to affect it. Invasion depth had a trend to influence locoregional control. For patients with early-stage disease without adverse factors, the locoregional control was similar between surgery alone group and surgery + radiotherapy group.
  
  
  CONCLUSIONS
  The survival of patients with buccal cancer was improved after 2002, which represented the start of intensity-modulated radiotherapy (IMRT) in our institute. Ipsilateral neck alone irradiation was recommended for T1-2N0-1 and small T3N0 disease, and bilateral neck irradiation could be reserved for advanced disease.
authors.affiliation: Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. chunshulin@gmail.com
authors.forename: Chun-Shu
authors.initials: CS
authors.lastname: Lin
authors.forename: Yee-Min
authors.initials: YM
authors.lastname: Jen
authors.forename: Woei-Yau
authors.initials: WY
authors.lastname: Kao
authors.forename: Ching-Liang
authors.initials: CL
authors.lastname: Ho
authors.forename: Ming-Shen
authors.initials: MS
authors.lastname: Dai
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Shih
authors.forename: Jen-Chan
authors.initials: JC
authors.lastname: Cheng
authors.forename: Ping-Ying
authors.initials: PY
authors.lastname: Chang
authors.forename: Wen-Yen
authors.initials: WY
authors.lastname: Huang
authors.forename: Yu-Fu
authors.initials: YF
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D002610:Cheek; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D015996:Survival Rate; D055815:Young Adult