title: Modulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthracene.
abstract: OBJECTIVE
  The aim of this study was to evaluate the chemopreventive potential of organoselenium compounds (Se I and Se II) in the well-established rat model treated with 7,12-dimethylbenz[a]anthracene (DMBA), by monitoring the extent of tyrosine hydroxylase (TH) activity, adrenomedullin (ADM) level and total RNA level in adrenal medulla. Organic pollutants are the most important environmental factor for the biologic systems. DMBA exposure appears to be associated with a number of physiological disease processes.
  
  
  METHODS
  The effects of Se I and Se II compounds were investigated on TH activity, ADM and total RNA levels in adrenal medulla of rats exposed to DMBA.
  
  
  RESULTS
  TH activity, ADM and total RNA levels were found to be increased significantly due to the effect of DMBA (p < 0.05). This increase was restricted in the Se I- and Se II-treated groups (p < 0.05).
  
  
  CONCLUSIONS
  The present data showed that the organoselenium compounds may have important effects in the maintainance of homeostasis against stress induced by DMBA.
authors.affiliation: Department of Biology, Faculty of Arts and Science, Nigde University, Nigde 51200, Turkey. ztalas44@hotmail.com
authors.forename: Zeliha Selamoglu
authors.initials: ZS
authors.lastname: Talas
authors.forename: Ilknur
authors.initials: I
authors.lastname: Ozdemir
authors.forename: Burhan
authors.initials: B
authors.lastname: Ates
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Gok
authors.forename: Ismet
authors.initials: I
authors.lastname: Yilmaz
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000313:Adrenal Medulla / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D053607:Adrenomedullin / Q000032:analysis / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D005260:Female; D020011:Protective Agents / Q000494:pharmacology*; D012313:RNA / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D020011:Protective Agents; D053607:Adrenomedullin; D015127:9,10-Dimethyl-1,2-benzanthracene; D012313:RNA; D014446:Tyrosine 3-Monooxygenase; D012643:Selenium