title: Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.
abstract: Finding new uses for old drugs is a strategy embraced by the pharmaceutical industry, with increasing participation from the academic sector. Drug repurposing efforts focus on identifying novel modes of action, but not in a systematic manner. With intensive data mining and curation, we aim to apply bio- and cheminformatics tools using the DRUGS database, containing 3,837 unique small molecules annotated on 1,750 proteins. These are likely to serve as drug targets and antitargets (i.e., associated with side effects, SE). The academic community, the pharmaceutical sector and clinicians alike could benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based on 7,684 approved drug labels, ADL (Dailymed) via text mining. From the ADL corresponding to 988 unique drugs, the "adverse reactions" section was mapped onto 174 SE, then clustered via principal component analysis into a 5x5 self-organizing map that was integrated into a Cytoscape network of SE-D-T-CO. This type of data can be used to streamline drug repurposing and may result in novel insights that can lead to the identification of novel drug actions.
authors.affiliation: Division of Biocomputing, Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC11 6145, Albuquerque, NM 87131, USA.
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
authors.forename: Sonny Kim
authors.initials: SK
authors.lastname: Nielsen
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Yang
authors.forename: Olivier
authors.initials: O
authors.lastname: Taboureau
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Mathias
authors.forename: Lrene
authors.initials: L
authors.lastname: Kouskoumvekaki
authors.forename: Larry A
authors.initials: LA
authors.lastname: Sklar
authors.forename: Cristian G
authors.initials: CG
authors.lastname: Bologa