title: Hepatitis C virus to hepatocellular carcinoma.
abstract: Hepatitis C virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma (HCC) in a significant number of patients via oxidative stress, insulin resistance (IR), fibrosis, liver cirrhosis and HCV induced steatosis. HCV induced steatosis and oxidative stress causes steato-hepatitis and these pathways lead to liver injury or HCC in chronic HCV infection. Steatosis and oxidative stress crosstalk play an important role in liver damage in HCV infection. This Review illustrates viral and host factors which induce Oxidative stress, steatosis and leads toward HCC. It also expresses Molecular cascade which leads oxidative stress and steatosis to HCC.
authors.affiliation: Department of Immunology, University of Health Sciences, Lahore, Pakistan. captainmalik@hotmail.com.
authors.forename: Shah
authors.initials: S
authors.lastname: Jahan
authors.forename: Usman A
authors.initials: UA
authors.lastname: Ashfaq
authors.forename: Muhammad
authors.initials: M
authors.lastname: Qasim
authors.forename: Saba
authors.initials: S
authors.lastname: Khaliq
authors.forename: Muhammad Javed
authors.initials: MJ
authors.lastname: Saleem
authors.forename: Nadeem
authors.initials: N
authors.lastname: Afzal