title: Synthetic Studies Towards MPC1001: Preparation of a β-hydroxyl-Tyrosine Derivative.
abstract: A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Schuber
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams