title: SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.
abstract: Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development.
authors.affiliation: Department of Cardiology, Center for Inflammation and Cancer, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Thang
authors.initials: T
authors.lastname: Van Nguyen
authors.forename: Pornpimon
authors.initials: P
authors.lastname: Angkasekwinai
authors.forename: Hong
authors.initials: H
authors.lastname: Dou
authors.forename: Feng-Ming
authors.initials: FM
authors.lastname: Lin
authors.forename: Long-Sheng
authors.initials: LS
authors.lastname: Lu
authors.forename: Jinke
authors.initials: J
authors.lastname: Cheng
authors.forename: Y Eugene
authors.initials: YE
authors.lastname: Chin
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
authors.forename: Edward T H
authors.initials: ET
authors.lastname: Yeh
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D058207:Sumoylation; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism / Q000502:physiology
chemical_list: D050799:STAT5 Transcription Factor; D025841:Small Ubiquitin-Related Modifier Proteins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C501974:Senp1 protein, mouse