title: Salvage prostatectomy post-definitive radiation therapy: The Vancouver experience.
abstract: BACKGROUND
  Prostate cancer recurrence following primary radiation is common. If the recurrence remains localized to the prostate gland, surgical removal may result in long-term local control or cure. Despite the well-established oncological outcomes, salvage prostatectomy is infrequently performed or reported. We present our experience with salvage prostatectomy at a Canadian centre.
  
  
  METHODS
  We identified all patients undergoing salvage prostatectomy at the Vancouver General Hospital between 1995 and 2010 from a prospectively recorded and maintained prostate cancer database. Details regarding initial presentation, delivery of radiotherapy, clinical features at the time of recurrence, as well as oncological and functional outcomes, were collected. Information regarding postoperative morbidity was collected prospectively and confirmed by retrospective chart review.
  
  
  RESULTS
  Over a 15-year period, salvage prostatectomy was successfully completed in 21 patients. With a median follow-up period of 68 months (range: 2-122), 9 (43%) patients experienced a biochemical recurrence, with most failing within the first 2 years of surgery. There were 3 deaths in the cohort, all from prostate cancer, giving a prostate cancer specific and overall survival of 86%. The main postoperative morbidity was bladder neck contracture, occurring in 40%. One patient each developed a recto-urethral fistula and osteitis pubis. Physician-recorded data regarding continence was available in 13 (62%). Of these 13 patients, 10 (85%) men were recorded as dry or using 1 pad per day.
  
  
  CONCLUSIONS
  This is the first Canadian centre to report that salvage prostatectomy can be performed with favourable oncological and functional outcomes.
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Niall M
authors.initials: NM
authors.lastname: Corcoran
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Guilherme
authors.initials: G
authors.lastname: Godoy
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Rodney C
authors.initials: RC
authors.lastname: Studd
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Rowan G
authors.initials: RG
authors.lastname: Casey
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Antonio
authors.initials: A
authors.lastname: Hurtado-Coll
authors.affiliation: Department of Radiation Oncology, BC Cancer Agency, Vancouver, BC.
authors.forename: Scott
authors.initials: S
authors.lastname: Tyldesley
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: S Larry
authors.initials: SL
authors.lastname: Goldenberg
authors.affiliation: Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC;
authors.forename: Martin E
authors.initials: ME
authors.lastname: Gleave