title: Dopamine D1 receptor gene polymorphism is associated with myocardial infarction.
abstract: Dopamine D1 receptor (DRD1) gene is associated with the pathogenesis of myocardial infarction (MI) in aspects of plaque rupture, platelet aggregation, and neutrophil-mediated injury of cardiac myocytes. Thus, the study was designed to explore whether the A-48G polymorphism of the DRD1 gene was associated with MI. The genotype of the DRD1A-48G polymorphism was determined by polymerase chain reaction in the 602 Han Chinese participants, 255 MI patients and 347 controls without MI. A significant association was found between the A-48G polymorphism of DRD1 and MI (genotype model: χ(2)=13.2, unadjusted p=0.001; χ(2)=13.9, adjusted p=0.0002; dominant model: adjusted OR 2.05, 95%CI 1.40-3.00, p=0.0002; recessive model: adjusted OR 2.34, 95%CI 1.01-5.39, p=0.047). The G allele was a risk-increased allele for MI (unadjusted OR 1.83, 95%CI 1.34-2.50, p=0.0001; adjusted OR 1.94, 95%CI 1.40-2.68, p=0.00007). Thus, the study demonstrated the significant association between A-48G polymorphism of the DRD1 gene and MI.
authors.affiliation: Department of Cardiology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
authors.forename: Zhuoxian
authors.initials: Z
authors.lastname: Zhao
authors.forename: Sheyu
authors.initials: S
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Deng
authors.forename: Tie
authors.initials: T
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Zeng
authors.forename: Xianming
authors.initials: X
authors.lastname: Mo
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000368:Aged; D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D017447:Receptors, Dopamine D1 / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D017447:Receptors, Dopamine D1