title: Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis.
abstract: Vascular endothelial growth factor (VEGF) and its receptors have recently reported to be expressed in human osteoarthritis (OA), suggesting that VEGF could be implicated in the pathogenesis of this disease. In the present study, expression of VEGF in the articular cartilage was determined in three different OA models: medial meniscectomy and monoiodoacetate (MIA) injection in rats and age-associated spontaneous joint cartilage destruction in guinea pigs. VEGF was detected by immunohistochemical analysis in the regenerative and hypertrophic chondrocytes, perichondrium and osteophyte areas and chondrocyte clones. Stain intensity of VEGF immunoreactivity increased simultaneously with the degree of cartilage destruction and reparation. These results suggest that VEGF is a key factor in the articular cartilage in human OA and animal OA models.
authors.affiliation: Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Yamairi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Utsumi
authors.forename: Yuuichi
authors.initials: Y
authors.lastname: Ono
authors.forename: Naruyasu
authors.initials: N
authors.lastname: Komorita
authors.forename: Masaharu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukunari