title: Assessment of sexual function in patients with cancer undergoing radiotherapy--a single centre prospective study.
abstract: OBJECTIVE
  The main objective was to delineate the rates and clinical course of sexual function and depression in cancer patients undergoing radiotherapy.
  
  
  METHODS
  Forty-eight male and 90 female radiotherapy-naive outpatients with breast or pelvic cancer completed the International Index of Erectile Function (IIEF) or the Female Sexual Function Index (FSFI), and the Hamilton Depression Scale (HDS) prior to (phase 1), at the end of (phase 2) and 12 months after radiotherapy (phase 3).
  
  
  RESULTS
  Overall, the majority of patients (93.8% of males and 80% of females) experienced intense sexual dysfunction. At presentation, males reported severe erectile dysfunction that was significantly associated with age. However, only in sexual desire was the difference between baseline and phase 3 significant. In females, an improvement was observed in all parameters of FSFI between phase 1 and 3. Females with stage III disease achieved lower scores in almost all parameters of FSFI than those with stage II. Finally, although a quarter of patients reported elevated depression scores, depression was not related to sexual function.
  
  
  CONCLUSIONS
  A significant proportion of cancer patients experience intense levels of sexual dysfunction and depression throughout radiotherapy and the subsequent year. Pelvic radiotherapy affected sexual function to a higher degree than did breast radiotherapy.
authors.affiliation: Department of Radiation Oncology, University of Patras Medical School, 26504, Rion, Patras, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vomvas
authors.forename: Gregoris
authors.initials: G
authors.lastname: Iconomou
authors.forename: Evanthia
authors.initials: E
authors.lastname: Soubasi
authors.forename: Michail
authors.initials: M
authors.lastname: Leotsinidis
authors.forename: Haralabos P
authors.initials: HP
authors.lastname: Kalofonos
authors.forename: Stavroula
authors.initials: S
authors.lastname: Beratis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kardamakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Assimakopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000532:radiotherapy*; D003863:Depression / Q000209:etiology / Q000523:psychology; D007172:Erectile Dysfunction / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology / Q000523:psychology; D011878:Radiotherapy / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000209:etiology* / Q000523:psychology; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology* / Q000523:psychology