title: Role of phospholipase Cε in physiological phosphoinositide signaling networks.
abstract: Receptor-initiated phospholipase C activation and generation of IP(3) and DAG are important common triggers for a diversity of signal transduction processes in many cell types. Contributing to this diversity is the existence and differential cellular and subcellular distribution of distinct phospholipase C isoforms with distinct regulatory properties. The recently identified PLCε enzyme is an isoform that is uniquely regulated by multiple upstream signals including ras-family GTP binding proteins as well as heterotrimeric G-proteins. In this review we will consider the well documented biochemical regulation of this isoform in the context of cell and whole animal physiology and in the context of other G protein-regulated PLC isoforms. These studies together reveal a surprisingly wide range of unexpected functions for PLCε in cellular signaling, physiology and disease.
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA. Alan_Smrcka@urmc.rochester.edu
authors.forename: Alan V
authors.initials: AV
authors.lastname: Smrcka
authors.forename: Joan Heller
authors.initials: JH
authors.lastname: Brown
authors.forename: George G
authors.initials: GG
authors.lastname: Holz
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D008958:Models, Molecular; D009206:Myocardium / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology; D010716:Phosphatidylinositols / Q000378:metabolism*; D054801:Phosphoinositide Phospholipase C / Q000737:chemistry / Q000378:metabolism*; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols; D020033:Protein Isoforms; D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon