title: Releasing the inner inhibition for axon regeneration.
abstract: The adult mammalian central nervous system exhibits restricted regenerative potential. Chen et al. (2011) and El Bejjani and Hammarlund (2012) used Caenorhabditis elegans to uncover intrinsic factors that inhibit regeneration of axotomized mature neurons, opening avenues for potential therapeutics.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. michelle.po@utoronto.ca
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Po
authors.forename: John A
authors.initials: JA
authors.lastname: Calarco
authors.forename: Mei
authors.initials: M
authors.lastname: Zhen
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D005820:Genetic Testing / Q000379:methods*; D008565:Membrane Proteins / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; C082460:Lin-12 protein, C elegans; D008565:Membrane Proteins; D051880:Receptors, Notch