title: Clinical significance of mitochondrial transcription factor A expression             in patients with colorectal cancer.
abstract: Mitochondrial transcription factor A (mtTFA) is necessary for both the transcription             and maintenance of mitochondrial DNA (mtDNA). The present study investigated the             relationship between clinicopathological factors, prognosis and the immunohistochemical             expression of mtTFA in the tumors of patients diagnosed with primary colorectal             cancer (CRC). Surgical specimens from 105 colorectal patients were immunohistochemically             stained using a polyclonal anti-mtTFA antibody. The relationships among the mtTFA             expression, clinicopathological factors and prognosis were evaluated. A total             of 47 (44.8%) of the 105 patients with CRC were determined to have positive mtTFA             expression. The positive expression of mtTFA significantly correlated with lymph             node metastasis, distant metastasis and advanced TNM staging. On the other hand,             negative mtTFA expression showed a tendency to correlate with high Ki-67 index.             The survival of patients with positive mtTFA expression was significantly worse             than that of patients with negative mtTFA expression. The positive mtTFA expression             appears to be a useful marker for tumor progression and poor prognosis in patients             with CRC.
authors.affiliation: Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, and Department of Gastroenterological and General Surgery, Wakamatsu Hospital, Kitakyushu, Japan. nakayama@med.uoeh-u.ac.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Masumi
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Noritaka
authors.initials: N
authors.lastname: Minagawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Torigoe
authors.forename: Hiroto
authors.initials: H
authors.lastname: Izumi
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Kohno
authors.forename: Koji
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D014157:Transcription Factors; C422562:mitochondrial transcription factor A