title: Agomelatine-induced akathisia with concomitant duloxetine medication: a case report.
abstract: A 29-year-old depressed, otherwise healthy female patient was treated with agomelatine and duloxetine. She developed subsequent akathisia, which subsided after cessation of agomelatine. As a cause we suggest a pharmacodynamic drug-drug interaction leading to noradrenergic overstimulation. We recommend only gradual dose titration when combining the 2 substances to minimize the risk for side effects.
authors.forename: C
authors.initials: C
authors.lastname: Imboden
authors.forename: M
authors.initials: M
authors.lastname: Hatzinger
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000328:Adult; D017109:Akathisia, Drug-Induced / Q000209:etiology*; D000928:Antidepressive Agents / Q000009:adverse effects*; D003865:Major Depressive Disorder / Q000188:drug therapy; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D013876:Thiophenes / Q000009:adverse effects*; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D000068736:Duloxetine Hydrochloride; D006993:Hypnotics and Sedatives; D013876:Thiophenes; C084711:agomelatine; D009281:Naphthalenes