title: Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors.
abstract: Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being precipitated in many cases by severe emotional stress. We describe six patients in whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/noradrenaline reuptake inhibitor venlafaxine, or its metabolite desvenlafaxine. Importantly, two of the six cases were not post-menopausal women. An increased risk of TTC may account for some of the reported cardiovascular adverse effects of venlafaxine and similar agents.
authors.affiliation: Department of Cardiology, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, SA 5011, Australia.
authors.forename: Christopher J A
authors.initials: CJ
authors.lastname: Neil
authors.forename: Cher-Rin
authors.initials: CR
authors.lastname: Chong
authors.forename: Thanh H
authors.initials: TH
authors.lastname: Nguyen
authors.forename: John D
authors.initials: JD
authors.lastname: Horowitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003511:Cyclohexanols / Q000009:adverse effects* / Q000627:therapeutic use; D000069468:Desvenlafaxine Succinate; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009647:Normetanephrine / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D054549:Takotsubo Cardiomyopathy / Q000139:chemically induced* / Q000503:physiopathology; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D000069468:Desvenlafaxine Succinate; D020097:Natriuretic Peptide, Brain; D009647:Normetanephrine; D010446:Peptide Fragments; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride; C109794:pro-brain natriuretic peptide (1-76)