title: Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives.
abstract: In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.
authors.affiliation: Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8501, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ohkubo
authors.forename: Yudai
authors.initials: Y
authors.lastname: Nishino
authors.forename: Yu
authors.initials: Y
authors.lastname: Ito
authors.forename: Hirosuke
authors.initials: H
authors.lastname: Tsunoda
authors.forename: Kohji
authors.initials: K
authors.lastname: Seio
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sekine
mesh_terms: D020029:Base Pairing; D001665:Binding Sites; D003562:Cytidine / Q000031:analogs & derivatives* / Q000737:chemistry; D015342:DNA Probes / Q000737:chemistry*; D007288:Inosine / Q000031:analogs & derivatives*; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000737:chemistry*
chemical_list: D015342:DNA Probes; C002908:2-thiocytidine; D007288:Inosine; D003562:Cytidine; D012313:RNA