title: [Investigation on the mechanisms for the suppression of cell proliferation in the dentate gyrus of the hippocampus in ACTH treated rats].
abstract: We previously reported that adrenocorticotropic hormone (ACTH)-treated rats serve as a valuable animal model for tricyclic antidepressant-resistant depressive conditions. The present study was undertaken to investigate the changes in neurogenesis in the hippocampus of ACTH-treated rats. Chronic treatment of ACTH decreased the number of bromodeoxyuridine-labeled cells in the dentate gyrus, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. Furthermore, chronic ACTH treatment also decreased the expression of brain-derived neurotrophic factor, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. These results suggest that antidepressant-resistant depression is caused by the suppression of neurogenesis, and the coadministration of imipramine and lithium, and electroconvulsive stimuli exert an antidepressant-like effect by recovering proliferative signals and neurogenesis.
authors.affiliation: Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Maho
authors.initials: M
authors.lastname: Doi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Onoue
authors.forename: Keiko
authors.initials: K
authors.lastname: Kuwatsuka
authors.forename: Ayaka
authors.initials: A
authors.lastname: Miyake
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shinomiya
authors.forename: Ikuko
authors.initials: I
authors.lastname: Miyazaki
authors.forename: Masato
authors.initials: M
authors.lastname: Aasanuma
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D018891:Dentate Gyrus / Q000166:cytology*; D003864:Depression, Chemical; D061218:Depressive Disorder, Treatment-Resistant / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D004565:Electroconvulsive Therapy; D006624:Hippocampus; D007099:Imipramine / Q000627:therapeutic use; D008094:Lithium / Q000627:therapeutic use; D055495:Neurogenesis / Q000187:drug effects*; D051381:Rats
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D000324:Adrenocorticotropic Hormone; D008094:Lithium; D007099:Imipramine