title: Autobiographical memory in amnestic Mild Cognitive Impairment.
abstract: Autobiographical memory (ABM) was evaluated in 19 patients with amnestic Mild Cognitive Impairment (aMCI) by means of the standardized enquiry developed by Borrini et al. (Psychol Med 19:215-224, 1989). Longitudinal assessments were carried out by re-testing participants at 9-month intervals up to three assessments over 18 months. Although aMCI patients performed significantly worse than age-, gender- and education-matched normal controls, all of them achieved above normal scores according to Italian norms. No evidence of disproportionate sparing of remote memories (i.e., classical temporal gradient, TG) was found. These findings contrast with the previously reported significant impairment of memory for public events (Bizzozero et al. in J Clin Exp Neuropsychol 31:48-56, 2009). Such a discrepancy might be attributed to the adopted ABM enquiry tapping "personal semantics", presumed to rely largely on prefrontal functions, in contrast with the mainly episodic qualification of memory for past public events, which is mostly dependent on hippocampal structures. Our results also support the hypothesis that the contents of remote memory archives may be differentially affected in aMCI.
authors.affiliation: Third Neurological Department, S. Paolo Hospital, University of Milan, via di Rudinì, 8, 20142 Milan, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bizzozero
authors.forename: Federica
authors.initials: F
authors.lastname: Lucchelli
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Saetti
authors.forename: Hans
authors.initials: H
authors.lastname: Spinnler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000209:etiology / Q000523:psychology; D060825:Cognitive Dysfunction / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D009483:Neuropsychological Tests