title: Comparative analysis of CA 125, ferritin, beta-2 microglobulin, lactic dehydrogenase levels in serum and peritoneal fluid in patients with ovarian neoplasia.
abstract: The aim of this study was to investigate the diagnostic role of the CA 125, ferritin, beta-2 microglobulin (β2 M), and lactic dehydrogenase (LDH) levels in serum and peritoneal fluid (PF) in patients with ovarian neoplasms. Using cross-sectional study design; serum and PF CA 125, ferritin, β2 M, and LDH levels were analyzed in 40 patients with benign ovarian neoplasms (Group 1) and 59 patients with malignant ovarian neoplasms (Group 2) which were evaluated surgically. Serum and PF levels of these markers compared between the groups. Diagnostic role of these markers were determined with receiver operating curve (ROC) analysis. Serum and PF CA 125, ferritin, β2 M, and LDH levels were statistically significant higher in patients with ovarian cancers as compared with benign neoplasms. Among these biomarkers, PF β2 M levels had highest sensitivity and specificity, 76.3 and 85%, respectively with the cut-off value: 2.3 mg/l. This study results indicates that especially PF β2 M and ferritin levels may be valuable for diagnosis of malignant ascites in patients with ovarian neoplasms.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, Turkey. ukucukgoz@yahoo.com
authors.forename: Umran
authors.initials: U
authors.lastname: Kucukgoz Gulec
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Ahmet Baris
authors.initials: AB
authors.lastname: Guzel
authors.forename: Selim
authors.initials: S
authors.lastname: Buyukkurt
authors.forename: Gulsah
authors.initials: G
authors.lastname: Seydaoglu
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Vardar
mesh_terms: D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000737:chemistry*; D018394:CA-125 Antigen / Q000032:analysis*; D000077216:Carcinoma, Ovarian Epithelial; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000032:analysis*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D018394:CA-125 Antigen; D001613:beta 2-Microglobulin; D005293:Ferritins; D007770:L-Lactate Dehydrogenase