title: γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H.
abstract: Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Scott
authors.forename: Carlo
authors.initials: C
authors.lastname: Mazzetti
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Simpson
authors.forename: Christine L
authors.initials: CL
authors.lastname: Willis
mesh_terms: D060326:Chemistry Techniques, Synthetic; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D016712:Mupirocin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007783:Lactones; D016712:Mupirocin