title: Genetics of Parkinson's disease.
abstract: The identification of genes contributing to Parkinson's disease (PD) has allowed for an improved understanding of the underlying pathogenesis of the disorder. The authors review the rapidly growing field of PD genetics, with a focus on the clinical, genetic, and pathophysiologic features of well-validated monogenic forms of PD caused by mutations in the  SNCA,  LRRK2,  PARKIN,  PINK1,  DJ-1, and  ATP13A2 genes. In addition, they discuss mutations in the  GBA gene, which increase susceptibility for PD. The authors also evaluate the implications of genome-wide association studies and stem cell-derived disease models and give recommendations for genetic testing.
authors.affiliation: Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Kishore R
authors.initials: KR
authors.lastname: Kumar
authors.forename: Ana
authors.initials: A
authors.lastname: Djarmati-Westenberger
authors.forename: Anne
authors.initials: A
authors.lastname: Grünewald
mesh_terms: D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology*