title: Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents.
abstract: A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by (1)H NMR, (13)C NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.
authors.affiliation: School of Chemical Sciences, Kannur University, Payyanur Campus, Kannur, Kerala, India.
authors.forename: Ranjith P
authors.initials: RP
authors.lastname: Karuvalam
authors.forename: Karickal R
authors.initials: KR
authors.lastname: Haridas
authors.forename: Susanta K
authors.initials: SK
authors.lastname: Nayak
authors.forename: Tayur N Guru
authors.initials: TN
authors.lastname: Row
authors.forename: P
authors.initials: P
authors.lastname: Rajeesh
authors.forename: R
authors.initials: R
authors.lastname: Rishikesan
authors.forename: N Suchetha
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009181:Mycoses / Q000188:drug therapy; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D013844:Thiazoles