title: [Combined use of contrast media containing iodine and gadolinium for imaging and intervention :  A hitherto widely ignored topic in radiological practice].
abstract: The synchronous use of chemically different contrast media in the same body compartment is a challenge for the radiologist, whether it is scheduled or unexpected. However, to inject contrast media containing iodine and gadolinium at the same time can be a prerequisite for the examination of several organs or organ systems. Unlike other topics of contrast-enhanced imaging procedures, the difficulties encountered with double contrast injections have been widely ignored in the literature. In the absence of reliable data from experimental and clinical studies the radiologist is dependent on case reports, information provided by the contrast media manufacturers, personal communications, mostly scanty personal experiences and a skilful time management, in order to overcome the situation. Only the combination of X-ray, computed tomography and magnetic resonance arthrography can be performed without another thought. However, the more or less synchronous vascular application of contrast media containing iodine and gadolinium requires vigilance. The more seriously ill the patient is, the more caution is advised even if the decision on the combined administration has to be reached urgently. The following overview gives a description of the properties of contrast media containing iodine and gadolinium as far as interactions following simultaneous administration are concerned. Subsequently, the clinically relevant situations and constellations are outlined and analyzed.
authors.affiliation: werner.golder@orange.fr
authors.forename: W
authors.initials: W
authors.lastname: Golder
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D004338:Drug Combinations; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007455:Iodine / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015641:Radiography, Interventional / Q000379:methods*; D013382:Subtraction Technique; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D007455:Iodine; D005682:Gadolinium