title: [Comparative characteristics of antioxidant properties of hypoglycemic agents diabenol and gliclazide].
abstract: The antioxidant properties of diabenol and gliclazide with reference to mexidol have been studied in vitro on several model systems, including chemiluminescence (CL) of lipids, CL with generation of reactive oxygen species (ROS), CL dependent on luminol oxidation by peroxy radicals, and the Glavind DPPH free-radical method. Diabenol exhibited the properties of a scavenger of superoxide anions and hydroxy and peroxy radicals in model CL systems with ROS generation. The activity of diabenol in inactivating ROS was about 8 times higher compared to mexidol. However, the antioxidant activity of diabenol in CL with peroxy radical generation was 3 times lower compared to mexidol. Gliclazide demonstrated dose-dependent antioxidant activity only on the model with stable DPPH radicals, where its inhibitory effect was 15 times greater than that of the reference drug.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: V A
authors.initials: VA
authors.lastname: Kosolapov
authors.forename: N I
authors.initials: NI
authors.lastname: Chepliaeva
mesh_terms: D001562:Benzimidazoles / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005907:Gliclazide / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D049449:Luminescence; D008165:Luminol / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010545:Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D010847:Picolines / Q000494:pharmacology; D010851:Picrates / Q000037:antagonists & inhibitors / Q000378:metabolism; D012996:Solutions; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: C501282:9-diethylaminoethyl-2,3-dihydroimidazo(1,2alpha)benzimidazole; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D007004:Hypoglycemic Agents; D010545:Peroxides; D010847:Picolines; D010851:Picrates; D012996:Solutions; D013481:Superoxides; C070020:emoxypine succinate; C049375:perhydroxyl radical; D008165:Luminol; C004931:1,1-diphenyl-2-picrylhydrazyl; D005907:Gliclazide