title: [Influence of peptide derivatives of diketopiperazines on hemopoietic stem cells of an intact organism and irradiated bone marrow cells in vitro].
abstract: We have performed structural and functional studies of the hemotropic activity for a number of novel 2,5-diketopiperazine peptidomimetic derivatives. We employed a mouse model of hemopoietic stem cells cloning in the spleen of lethally irradiated animals. Biologic activity of synthetic products was studied in two experimental models: 1) in vitro irradiated bone marrow SFU-S was used for studying the radio modifying activity; 2) the biological effect of peptidomimetics on the intact non-irradiated bone marrow was evaluated in vivo. Various ways of administration of the peptidomimetics studied were used in the in vivo experiments: intravenous, intraperitoneal or subcutaneous injections and oral administration in the dose range of 10-10000 microg/kg. As a result of our work, we have discovered 2,5-diketopiperazine peptidomimetic derivatives with the dual activity: stimulation of intact committed SFU-S and radiomodifying activity.
authors.forename: V I
authors.initials: VI
authors.lastname: Deĭgin
authors.forename: A S
authors.initials: AS
authors.lastname: Saenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Semin
authors.forename: A S
authors.initials: AS
authors.lastname: Shevchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Luzianina
authors.forename: O S
authors.initials: OS
authors.lastname: Izmest'eva
authors.forename: L P
authors.initials: LP
authors.lastname: Zhavoronkov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D054659:Diketopiperazines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004334:Drug Administration Schedule; D004355:Drug Stability; D005260:Female; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D057786:Peptidomimetics / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011830:Radiation Effects; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects
chemical_list: D054659:Diketopiperazines; D057786:Peptidomimetics