title: [The tumor suppressor HACE1 targets Rac1 to ubiquitin-mediated proteasomal degradation].
authors.affiliation: Institut Cochin, Département de Génétique et Développement, Inserm U1016, CNRS UMR8104, Université Paris Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France. gerard.gacon@inserm.fr
authors.forename: Gérard
authors.initials: G
authors.lastname: Gacon
authors.forename: Amel
authors.initials: A
authors.lastname: Mettouchi
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lemichez
mesh_terms: D000634:Aminoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D029968:Escherichia coli Proteins / Q000494:pharmacology; D016147:Genes, Tumor Suppressor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000502:physiology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D034622:RNA Interference; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D054875:Ubiquitination; D009396:Wilms Tumor / Q000235:genetics / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D001427:Bacterial Toxins; D004791:Enzyme Inhibitors; D029968:Escherichia coli Proteins; C487513:NSC 23766; D009363:Neoplasm Proteins; D009479:Neuropeptides; D011743:Pyrimidines; C107953:RAC1 protein, human; C484602:Rac1 protein, mouse; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; C060296:cytotoxic necrotizing factor type 1; C497506:HACE1 protein, human; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins