title: Buerger's disease.
abstract: Buerger's disease (thromboangiitis obliterans) is a nonatherosclerotic segmental inflammatory disease of small- and medium-sized arteries of the distal extremities of predominantly young male tobacco users. Early symptoms may include episodic pain and coldness in fingers, and late findings may present as intermittent claudication, skin ulcers, or gangrene requiring eventual amputation. Tobacco cessation is the cornerstone of treatment. Other modalities of reducing pain or avoiding amputation have not been as successful. This review summarizes in tabular form the types of treatment that have been used, including therapeutic angiogenesis.
authors.affiliation: Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Phong T
authors.initials: PT
authors.lastname: Dargon
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Landry
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D019917:Blood Vessel Prosthesis Implantation; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic / Q000187:drug effects; D018570:Risk Assessment; D012307:Risk Factors; D016540:Smoking Cessation; D013919:Thromboangiitis Obliterans / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D002317:Cardiovascular Agents