title: Androgen deprivation therapy-associated vasomotor symptoms.
abstract: Androgen deprivation therapy (ADT) is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.
authors.affiliation: Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Jones
authors.forename: Manish
authors.initials: M
authors.lastname: Kohli
authors.forename: Charles L
authors.initials: CL
authors.lastname: Loprinzi
mesh_terms: D000588:Amines / Q000627:therapeutic use; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D019584:Hot Flashes / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D008297:Male; D000069583:Pregabalin; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000588:Amines; D000726:Androgen Antagonists; D000927:Anticonvulsants; D000928:Antidepressive Agents; D003509:Cyclohexanecarboxylic Acids; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin