title: Totally implantable central venous access ports in patients with cystic fibrosis: a multicenter prospective cohort study.
abstract: OBJECTIVE
  The aim of this study was to assess the incidence of late onset complications of totally implantable venous access devices (TIVAD) in patients with cystic fibrosis (CF) and to investigate possible associations between the rate of complications and different policies of TIVAD management.
  
  
  METHODS
  A multicenter prospective cohort study was performed in 11 Italian CF Centers. Patients with CF and a TIVAD were recruited and followed-up.
  
  
  RESULTS
  The study commenced on May 2008 and ended on September 2010. Eighty subjects were studied (77.5% women--mean age 27.2 years). Eighteen late complications of ports were observed (22.5%; incidence 0.96 per 1000 days of observation): three lumen occlusions, seven catheter-related infections , three port-related venous thrombosis, in addition to five other complications. A statistically significant association was found between the onset of catheter-related infection and the presence of CF-related diabetes (CFRD) (P=.0064)
  
  
  CONCLUSIONS
  Our data suggest that TIVADs represent a safe and effective device for the intermittent IV administration of drugs in people with CF. However, people with CFRD have a higher risk of developing TIVAD-related infection.
authors.affiliation: Nursing School, Biella Hospital, University of Piemonte Orientale, Italy. alberto.dalmolin@gmail.com
authors.forename: Alberto
authors.initials: A
authors.lastname: Dal Molin
authors.forename: Dino Stefano
authors.initials: DS
authors.lastname: Di Massimo
authors.forename: Cesare
authors.initials: C
authors.lastname: Braggion
authors.forename: Sofia
authors.initials: S
authors.lastname: Bisogni
authors.forename: Elena
authors.initials: E
authors.lastname: Rizzi
authors.forename: Ciro
authors.initials: C
authors.lastname: D'Orazio
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Di Toppa
authors.forename: Federico
authors.initials: F
authors.lastname: Alghisi
authors.forename: Simona
authors.initials: S
authors.lastname: Cristadoro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carnovale
authors.forename: Gabriella
authors.initials: G
authors.lastname: Festa
authors.forename: Serena
authors.initials: S
authors.lastname: Rampini
authors.forename: Carla
authors.initials: C
authors.lastname: Colombo
authors.forename: Anna
authors.initials: A
authors.lastname: Oneta
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Furnari
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Calamia
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Zunino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tuccio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Spadea
authors.forename: Barbara
authors.initials: B
authors.lastname: Messore
authors.forename: Bianca
authors.initials: B
authors.lastname: Grosso
authors.forename: Filippo
authors.initials: F
authors.lastname: Festini
mesh_terms: D000328:Adult; D061807:Catheter Obstruction; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000453:epidemiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation*; D002408:Catheters, Indwelling; D062905:Central Venous Catheters; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy; D004867:Equipment Design; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D056824:Upper Extremity Deep Vein Thrombosis / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult