title: Pharmacological agents that affect sperm motility.
abstract: Male fertility is determined by several factors one of which is essential sperm motility. A large number of drugs have a toxic influence on sperm motility
  
  
  METHODS
  We tested the influence of some antibacterial antibiotics on rat sperm motility. Following antibiotics were tested antibacterial influences: amoxicillin + clavulanic acid dose of 30 mg/kg body/day, daily and that 150 mg/kgbody/day, daily, respectively ceftazidime dose of 50 mg/kgbody/day, daily and that 250 mg/kgbody/day, daily. For each antibiotic and dose was used by a group of rats that received treatment for 12 days for amoxicillin+clavulanic acid and 11 days, respectively 10 days for ceftazidime. A control group of rats was not received and no substance Sperm motility was determined and histopathological examination of tissues was performed harvested.
  
  
  RESULTS
  Our data showed that the combination of amoxicillin-clavulanic acid in doses of 30 mg/kgbody/day (dose is reached in clinical practice) of sperm motility reduced with 49.33% (p<0.01) and dose of 150 mg/kgbody/day, sperm motility was reduced with 68.96% (p<0.01) ceftazidime doses tested significantly reduced motility of sperm (p<0.01), dose of 50 mg/kgbody/day, sperm motility was reduced with 83.79% and dose of 250 mg/kgbody/day, sperm motility was reduced with 85.36% (p<0.01).
  
  
  CONCLUSIONS
  Ceftazidim has a strong effect on sperm cells motility at therapeutic doses. This effect is higher compared to amoxicillin+clavulanic acid association.
authors.affiliation: "Gr. T. Popa" University of Medicine and Pharmacy Iasi.
authors.forename: Elena
authors.initials: E
authors.lastname: Antohi
authors.forename: Cristina
authors.initials: C
authors.lastname: Gales
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
mesh_terms: D000465:Algorithms; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005298:Fertility / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D002442:Ceftazidime