title: Siglecs as sensors of self in innate and adaptive immune responses.
abstract: Siglecs are expressed on most white blood cells of the immune system and are known to modulate the activity of cell signaling receptors via regulatory motifs in their cytoplasmic domains. This immunoglobulin subfamily of coreceptors recognize sialic acid containing glycans as ligands, which are found on glycoproteins and glycolipids of all mammalian cells. By virtue of their ability to recognize this common structural element, siglecs are increasingly recognized for their ability to help immune cells distinguish between self and nonself, and dampen autoimmune responses.
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA. jpaulson@scripps.edu
authors.forename: James C
authors.initials: JC
authors.lastname: Paulson
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Macauley
authors.forename: Norihito
authors.initials: N
authors.lastname: Kawasaki
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001324:Autoantigens / Q000737:chemistry; D006801:Humans; D007113:Immunity, Innate; D037102:Lectins / Q000276:immunology*; D008024:Ligands; D051379:Mice; D018448:Models, Immunological; D011134:Polysaccharides / Q000737:chemistry / Q000276:immunology; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D012794:Sialic Acids / Q000737:chemistry / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D001324:Autoantigens; D037102:Lectins; D008024:Ligands; D011134:Polysaccharides; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D012794:Sialic Acids; D051193:Toll-Like Receptors