title: Assessment of the CKD-EPI equation to estimate glomerular filtration rate in adults from a Chinese CKD population.
abstract: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was introduced to estimate glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients based on serum creatinine. The CKD-EPI equation shows better accuracy compared with the current gold standard  equation, the Modification of Diet in Renal Disease (MDRD) equation, but it has not been externally validated in Chinese patients. This study compared the CKD-EPI equation with the original MDRD equation and two Chinese MDRD-based equations for estimating GFR in 200 Chinese CKD patients. The  (99m)Tc-diethylenetriamine penta-acetate ((99m)Tc-DTPA) method was used to determine actual GFR. The CKD-EPI equation produced GFR estimates that were more consistent with the (99m)Tc-DTPA GFR than did the MDRD equations. The precision and accuracy of the CKD-EPI  equation were significantly higher than those of the MDRD equations. In conclusion, the CKD-EPI equation was superior to the existing MDRD equations in terms of estimating GFR and we recommend its clinical use in Chinese CKD patients.
authors.affiliation: Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liao
authors.forename: W
authors.initials: W
authors.lastname: Liao
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016284:Technetium Tc 99m Pentetate; D055815:Young Adult
chemical_list: D003404:Creatinine; D016284:Technetium Tc 99m Pentetate