title: Conformationally controlled mechanistic aspects of BACE 1 inhibitors.
abstract: This study highlights conformationally controlled mechanistic aspects of peptide inhibitors for BACE 1. Peptide inhibitors with reduced molecular weight tend to have cyclic conformation leading to reduced interactions with catalytic motif. Conformation plays a major role in determining potency of peptide inhibitors. An attempt has been made at designing lead compound with reduced molecular weight along with proper conformation suitable for active site and retention of specificity analogous to natural substrate. Reduced molecular weight should hopefully lead to enhanced bioavailability.
authors.affiliation: Department of Chemistry, University Institute of Engineering and Technology, CSJM University Kanpur, India. Minakshi.uiet@yahoo.co.in
authors.forename: M
authors.initials: M
authors.lastname: Sonker
authors.forename: A
authors.initials: A
authors.lastname: Yadav
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D020134:Catalytic Domain / Q000187:drug effects / Q000502:physiology; D018360:Crystallography, X-Ray / Q000379:methods; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation
chemical_list: D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human