title: Effects of inherited thrombophilia in women with recurrent pregnancy loss.
abstract: OBJECTIVE
  To evaluate the prevalence and effects of inherited thrombophilia caused by factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with recurrent pregnancy loss.
  
  
  METHODS
  A study group of 97 women with recurrent miscarriages and a control group of 71 healthy pregnant women were included in the study. Genotype analyses for factor V Leiden, prothrombin G20210A and MTHFR C677T polymorphisms were performed by real-time polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  The frequency of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations were similar in both the study and control group. There were eight patients (8.2%) who had more than one gene mutation in the study group and one patient in the control group (1.4%). This difference was not statistically significant. Study group patients (n = 97) were compared in terms of the number of miscarriages and the abortion week, in addition to being a carrier of factor V Leiden and MTHFR C677T gene mutations. No statistically significant correlation was found between being a factor V Leiden and MTHFR C677T mutation carrier with either the number of miscarriages or the abortion week.
  
  
  CONCLUSIONS
  Factor V Leiden, prothrombin G20210A and MTHFR C677T gene mutations are not individually related with recurrent pregnancy loss. However, combined gene mutation status may be associated with recurrent miscarriages.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University School of Medicine, Bornova, Izmir, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Habibovic
authors.forename: B
authors.initials: B
authors.lastname: Zeybek
authors.forename: C
authors.initials: C
authors.lastname: Sanhal
authors.forename: Z
authors.initials: Z
authors.lastname: Eroglu
authors.forename: E
authors.initials: E
authors.lastname: Karaca
authors.forename: M
authors.initials: M
authors.lastname: Ulukus
mesh_terms: D000026:Abortion, Habitual; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000235:genetics*; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)