title: Ciclesonide--a novel corticosteroid for the management of asthma.
abstract: Ciclesonide (CIC) is a novel inhaled corticosteroid (ICS) approved by US Food and Drug Administration for the treatment of persistent asthma, available as a pressurized metered-dose inhaler in two strengths, 80 mcg/activation and 160 mcg/activation. Ciclesonide is a corticosteroid with unique pharmacological profile including a high degree of serum protein binding, a low oral bioavailability and rapid systemic elimination. Ciclesonide is a prodrug metabolized by esterases to desisobutyryl ciclesonide (des-CIC), an active metabolite with a 100-fold greater affinity for the glucocorticoid receptor. It has shown to improve pulmonary functions, reduce the need for oral corticosteroids (OCSs) and cause lesser suppression of the hypothalamic-pituitary-adrenal axis in asthmatic patients. Clinical efficacy studies suggest that Ciclesonide is superior to placebo and is at least as effective as several active comparators with an improved therapeutic margin thereby improving the therapeutic outcome in patients of asthma.
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Chopra
authors.forename: Bharti
authors.initials: B
authors.lastname: Bhandari
authors.forename: Neeta
authors.initials: N
authors.lastname: Wardhan
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001682:Biological Availability; D006801:Humans; D036501:Metered Dose Inhalers; D011282:Pregnenediones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011355:Prodrugs; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D011282:Pregnenediones; D011355:Prodrugs; D011965:Receptors, Glucocorticoid; C494355:desisobutyrylciclesonide; C120481:ciclesonide