title: Young people at ultra high risk for psychosis: research from the PACE clinic.
abstract: Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).
authors.affiliation: Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia. aryung@unimelb.edu.au
authors.forename: Alison R
authors.initials: AR
authors.lastname: Yung
authors.forename: Barnaby
authors.initials: B
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D035843:Biomedical Research; D015928:Cognitive Behavioral Therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D042241:Early Diagnosis; D061345:Early Medical Intervention / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000628:therapy; D055815:Young Adult