title: A parathyroid carcinoma within a cold thyroid nodule.
abstract: We report the case of a 71-year-old woman who was referred to our institute with a solid nodule in the right thyroid lobe and hypercalcemia. Ultrasound revealed a well-vascularized right thyroid nodule that was identified as a cold area by (99m)Tc-sodium pertechnetate scan. Fine-needle aspiration showed a follicular lesion and blood tests revealed hypercalcemia and hyperparathyroidism. A (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-Sestamibi) scan was subsequently performed revealing a focal area of increased uptake in the right thyroid lobe, within the cold area detected by the thyroid scan. A right emithyroidectomy and right superior and inferior parathyroidectomy was performed and histopathological examination showed a parathyroid carcinoma (immunohistochemistry positive for PTH and chromogranin A, Ki-67 10%) associated with follicular hyperplasia.
authors.affiliation: Nuclear Medicine Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
authors.forename: Ll
authors.initials: L
authors.lastname: Travaini
authors.forename: G
authors.initials: G
authors.lastname: Trifiro
authors.forename: G
authors.initials: G
authors.lastname: Paganelli