title: High-grade supraclavicular soft tissue sarcoma as secondary malignancy after successful treatment of acute myeloid leukemia: case report and literature review.
abstract: It is well known that the treatment protocols for hematopoetic neoplasms carry a high risk of long-term oncogenicity. However, few reports have been published of sarcomas as secondary malignancies. An unusual case report of a soft tissue sarcoma appearing as a secondary cancer is presented, with a review of the published data. The present report involves a soft tissue sarcoma of the neck that occurred 18 years after curative treatment of acute myeloid leukemia by induction chemotherapy and bone marrow transplantation. Consecutive graft-versus-host disease affected the cervical skin. Soft tissue sarcomas appearing as secondary tumors are rare in oncology. The presented case describes the appearance of a sarcoma 18 years after curative treatment of acute myeloid leukemia. This is only the second case of this type reported in published studies.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universiät München, Munich, Germany. matthias_troeltzsch@hotmail.com
authors.forename: Matthias
authors.initials: M
authors.lastname: Troeltzsch
authors.forename: Herbert
authors.initials: H
authors.lastname: Stimmer
authors.forename: Rupert
authors.initials: R
authors.lastname: Langer
authors.forename: Markus
authors.initials: M
authors.lastname: Troeltzsch
authors.forename: Timm
authors.initials: T
authors.lastname: Steiner
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000473:pathology*; D009334:Neck Muscles / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation