title: Overview of animal models of asthma.
abstract: Asthma is an inflammatory disease characterized by airways obstruction, airways hyperresponsiveness, excessive mucous secretion and cough. Guinea pig airways display many anatomical, physiological and pharmacological attributes of human airways, making this species ideal for modeling the asthmatic condition. This unit provides an overview of animal models of asthma, including definitions, descriptions of available animal models, and discussion of numerous critical issues to consider before designing a model to study this complex disease.
authors.affiliation: Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA.
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Canning
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D012898:Autacoids / Q000494:pharmacology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D001986:Bronchial Spasm / Q000503:physiopathology; D001991:Bronchitis / Q000503:physiopathology; D002415:Cats; D016207:Cytokines / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012129:Respiratory Function Tests
chemical_list: D018927:Anti-Asthmatic Agents; D012898:Autacoids; D016207:Cytokines; D018377:Neurotransmitter Agents