title: Cyberknife radiosurgery in treating trigeminal neuralgia.
abstract: OBJECTIVE
  To assess the short term efficacy of Cyberknife stereotactic radiosurgical treatment of trigeminal neuralgia (TN).
  
  
  METHODS
  17 consecutive patients with medically or surgically refractory unilateral TN were treated with Cyberknife radiosurgery. Using superimposed CT cisternogram and MR images, the target segment of the trigeminal nerve was consistently defined as a 6 mm length of nerve approximately 2-3 mm distal to the dorsal root entry zone of the brainstem. A radiosurgical rhizotomy was performed with the Cyberknife utilizing a single collimator to deliver an average maximum dose of 73.06 Gy (range 72.91-73.73) to the target.
  
  
  RESULTS
  Follow-up data were available for 16 of the 17 patients post-treatment (range 1-27 months, average 11.8 months). Overall, 14 of 16 (88%) patients responded favorably with either partial or complete relief of symptomatology. 11 of these patients were successfully free of all pain at some point in their post-treatment course, with seven patients pain free to the last follow-up visit (average 5.0 months, range 1-13 months). Symptoms recurred in four patients, taking place at 3, 7.75, 9 and 18 months after Cyberknife therapy. Only two patients reported side effects. One patient developed a bothersome feathery dysesthesia while the second patient reported a non-bothersome mild jaw hypoesthesia. There were no substantial complications related to stereotactic radiosurgery.
  
  
  CONCLUSIONS
  Cyberknife radiosurgery is a viable treatment alternative in patients with TN with competitive efficacy demonstrated in our group of patients while minimizing adverse effects.
authors.affiliation: Department of Radiology, Winthrop-University Hospital, Mineola, New York 11501, USA.
authors.forename: Bryan M
authors.initials: BM
authors.lastname: Lazzara
authors.forename: Orlando
authors.initials: O
authors.lastname: Ortiz
authors.forename: Ritu
authors.initials: R
authors.lastname: Bordia
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Witten
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Haas
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Katz
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000175:diagnosis* / Q000601:surgery*