title: Haemostatic alterations in a group of canine cancer patients are associated with cancer type and disease progression.
abstract: BACKGROUND
  Haemostatic alterations are commonly detected in human and canine cancer patients. Previous studies have described haemostatic dysfunction in canine patients with haemangiosarcomas and carcinomas, and haemostasis has been assessed in dogs with various malignant and benign neoplasias. Few studies have addressed the effect of cancer type and progression of disease on the presence of haemostatic alterations in canine patients. The objective of the present study was to evaluate haemostatic variables of coagulation and fibrinolysis in a group of canine cancer patients, and to compare haemostatic changes to the cancer type and progression of disease.
  
  
  METHODS
  The study population consisted of 71 dogs with malignant neoplasia presented to the University Hospital for Companion Animals, Faculty of Life Sciences, University of Copenhagen, Denmark. The study was designed as a prospective observational study evaluating the haemostatic function in canine cancer patients stratified according to type of cancer disease and disease progression. The coagulation response was evaluated by thromboelastrography (TEG), platelet count, activated partial thromboplastin time (aPTT), prothombin time (PT), fibrinogen and antithrombin (AT); and fibrinolysis by d-dimer and plasminogen.
  
  
  RESULTS
  Hypercoagulability was the most common haemostatic dysfunction found. Non mammary carcinomas had increased clot strength (TEG G), aPTT and fibrinogen compared to the other groups. When stratifying the patients according to disease progression dogs with distant metastatic disease exhibited significantly increased fibrinogen, and d-dimer compared to dogs with local invasive and local non-invasive cancers.
  
  
  CONCLUSIONS
  Hypercoagulability was confirmed as the most common haemostatic abnormality in canine cancer patients and haemostatic dysfunction in canine cancer patients was found related to the cancer type and progression of disease. Increase in TEG G, aPTT and fibrinogen were observed in non-mammary carcinomas and were speculated to overall represent a proinflammatory response associated with the disease. Dogs with distant metastatic disease exhibited increased fibrinogen and d-dimer. Future studies are needed to elucidate the clinical importance of these results.
authors.affiliation: Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Denmark. eba@life.ku.dk
authors.forename: Eva B
authors.initials: EB
authors.lastname: Andreasen
authors.forename: Mikael
authors.initials: M
authors.lastname: Tranholm
authors.forename: Bo
authors.initials: B
authors.lastname: Wiinberg
authors.forename: Bo
authors.initials: B
authors.lastname: Markussen
authors.forename: Annemarie T
authors.initials: AT
authors.lastname: Kristensen
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D003718:Denmark; D018450:Disease Progression; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D020141:Hemostatic Disorders / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000662:veterinary*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000494:pharmacology; D013916:Thrombelastography / Q000662:veterinary; D013925:Thromboplastin / Q000494:pharmacology*
chemical_list: D011994:Recombinant Proteins; D013925:Thromboplastin