title: Spontaneous iron accumulation in hepatocytes of a 7-week-old female rat.
abstract: Spontaneous iron accumulation in hepatocytes was observed in a 7-week-old female Han Wistar GALAS rat. Very fine yellowish brown pigments, which showed a positive reaction with Berlin Blue stain, were apparent in the cytoplasm close to the bile canaliculi, with a diminishing periportal-to-centrilobular gradient. There were also differences in distribution between and within lobes. Transmission electron microscopy revealed cytosolic ferritin and pericanalicular siderosomes in hepatocytes. No degeneration or necrotic changes were observed, and non-hepatocyte cells did not demonstrate any obvious accumulation of iron. There were no abnormalities in the animal other than this finding in the liver.
authors.forename: Kaori
authors.initials: K
authors.lastname: Miyata
authors.forename: Tokuo
authors.initials: T
authors.lastname: Sukata
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kushida
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogata
authors.forename: Manabu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ozaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Uwagawa