title: Cyclosporine a eye drop-induced elongated eyelashes: a case report.
abstract: OBJECTIVE
  The most common ocular adverse event following the use of cyclosporine A (CsA) 0.05% ophthalmic emulsion is ocular burning (17%). Other adverse effects that have been reported include conjunctival hyperemia (1-5%), discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging and blurred vision. Here, we report a specific side effect of CsA, namely eye drop-induced eyelash elongation in a patient with refractory giant papillary conjunctivitis.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  Case report and review of the literature.
  
  
  RESULTS
  A 32-year-old female with giant papillary conjunctivitis on the left eye, who had undergone papillectomy 3 years previously and was refractory to topical steroid therapy, was treated with CsA 0.05% ophthalmic emulsion (Restasis) 4 times a day, preservative-frees artificial tears and gentamicin ophthalmic solution in the left eye. After 5 months of topical CsA treatment, elongated eyelashes of her left eye were observed without other adverse effects.
  
  
  CONCLUSIONS
  Although hypertrichosis and trichomegaly have been documented in the literature as side effects of systemic CsA, topical CsA 0.05% eye drop-induced elongated eyelashes have not been reported, and we believe ophthalmologists should be mindful and inform patients about this specific side effect.
authors.affiliation: Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC.
authors.forename: Hsiao-Lei
authors.initials: HL
authors.lastname: Lei
authors.forename: Wan-Chen
authors.initials: WC
authors.lastname: Ku
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Sun
authors.forename: Kuan-Jen
authors.initials: KJ
authors.lastname: Chen
authors.forename: Jui-Yang
authors.initials: JY
authors.lastname: Lai
authors.forename: Chi-Chin
authors.initials: CC
authors.lastname: Sun