title: IgM nephropathy in India: a single centre experience.
abstract: OBJECTIVE
  To find out the incidence and natural history of IgMN in India.
  
  
  METHODS
  Renal biopsies of children ≤12 y age of last 6 y were retrospectively evaluated. Their clinical and biochemical presentation were correlated. Patients with systemic diseases/disorders were excluded from the study.
  
  
  RESULTS
  Immunoglobulin M nephropathy (IgMN) constituted 11.9% (n = 28) of 236 renal biopsies. Mean age was 10 y, predominant in boys (n = 24), most of the patients presented with proteinuria and edema. The most common associated histopathological finding was mesangial proliferative glomerulonephritis (MePGN) in 60.7% (n = 17) followed by minimal change disease (MCD) in 28.6% (n = 8) and focal segmental glomerulosclerosis (FSGS) in 10.7% (n = 3). In 85.7%, IgM appeared as the sole immunoglobulin deposit mainly in mesangial regions, followed by accompanied C3 in 3.6% (n = 1) and C1q + C3 in 10.7% (n = 3) biopsies.
  
  
  CONCLUSIONS
  IgMN was observed in 11.9% biopsies with commonest morphology of MePGN followed by MCD and FSGS; proteinuria was bad prognosticator in addition to FSGS and co-deposition of other immunoglobulins had no significance.
authors.affiliation: Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad, 380016 Gujarat, India. vanikararuna@yahoo.com
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: Kamal V
authors.initials: KV
authors.lastname: Kanodia
authors.forename: Rashmi D
authors.initials: RD
authors.lastname: Patel
authors.forename: Kamlesh S
authors.initials: KS
authors.lastname: Suthar
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Patel
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Gumber
authors.forename: Hargovind L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D009404:Nephrotic Syndrome / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D007075:Immunoglobulin M