title: Pre-clinical models of renal carcinoma and their utility in drug development.
abstract: Significant progress has been made in the treatment of patients with advanced renal cancer. In addition to immunotherapy, there are several potentially distinct therapeutic approaches for targeting molecular pathways. The murine models detailed in this unit are useful for testing rational combination strategies. Moreover, animal models contribute immensely to the understanding of the genetic, epigenetic, and biological aspects of human disease. Compared to humans, rodent models are relatively short-lived and allow for the facile study of clinically relevant pathologies. Animal models for the study of renal cell carcinoma (RCC) are particularly useful for the development of new drugs for kidney cancer. Included in this unit are several in vivo models that are currently used to evaluate therapeutic approaches to renal cancer therapy and to investigate the pathophysiology of this condition. Included are both murine (RENCA) and renal cell carcinomas in subcutaneous and orthotopic models using tumor cell lines and human tumor tissue.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.
authors.forename: Brenda C
authors.initials: BC
authors.lastname: Salumbides
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Lehet
authors.forename: Georges
authors.initials: G
authors.lastname: Ndikuyeze
authors.forename: Roberto
authors.initials: R
authors.lastname: Pili
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008163:Luminescent Measurements; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation / Q000379:methods; D012996:Solutions
chemical_list: D007202:Indicators and Reagents; D012996:Solutions