title: Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.
abstract: Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4(+)CADM1(+) double-positive cells correlated well with both the percentages of CD4(+)CD25(+) cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4(+)CADM1(+) cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4(+)CADM1(+) cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.
authors.affiliation: Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakahata
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Marutsuka
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: T
authors.initials: T
authors.lastname: Shiraga
authors.forename: A
authors.initials: A
authors.lastname: Goto
authors.forename: N
authors.initials: N
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
authors.forename: A
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: A
authors.initials: A
authors.lastname: Okayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kubuki
authors.forename: K
authors.initials: K
authors.lastname: Shimoda
authors.forename: Y
authors.initials: Y
authors.lastname: Ukai
authors.forename: G
authors.initials: G
authors.lastname: Kurosawa
authors.forename: K
authors.initials: K
authors.lastname: Morishita
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D004279:DNA, Viral / Q000235:genetics; D018450:Disease Progression; D005434:Flow Cytometry; D015490:HTLV-I Infections / Q000175:diagnosis* / Q000235:genetics / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000378:metabolism* / Q000821:virology; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D011533:Proviruses / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D019562:Viral Load
chemical_list: C403514:CADM1 protein, human; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules; D004279:DNA, Viral; D007136:Immunoglobulins; D025521:Tumor Suppressor Proteins