title: Progestin intrauterine device in an adolescent with grade 2 endometrial cancer.
abstract: BACKGROUND
  The treatment of endometrial cancer in young women who desire future fertility poses several challenges. Oral progestin and progestin-releasing intrauterine devices (IUDs) have been shown to result in regression of endometrial hyperplasia and grade 1 endometrioid endometrial carcinoma. However, limited data are available on the use of these methods in women with grade 2 disease.
  
  
  METHODS
  An 18-year-old nulliparous woman was diagnosed with a grade 2 endometrial adenocarcinoma. She desired future fertility and therefore underwent placement of a levonorgestrel-releasing IUD. The patient subsequently underwent endometrial sampling every 3 months and remained disease-free 13 months after initial IUD placement.
  
  
  CONCLUSIONS
  A progestin-releasing IUD may be a valid treatment option for grade 2 endometrial cancer in young women who desire to retain fertility.
authors.affiliation: From the Department of Gynecology and Obstetrics, the Johns Hopkins Medical Institutions, Baltimore, Maryland; and the Departments of Gynecologic Oncology and Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Alaina J
authors.initials: AJ
authors.lastname: Brown
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Westin
authors.forename: Russell R
authors.initials: RR
authors.lastname: Broaddus
authors.forename: Kathleen
authors.initials: K
authors.lastname: Schmeler
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000293:Adolescent; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000008:administration & dosage*; D059351:Organ Sparing Treatments
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel