title: Annonamine, a new aporphine alkaloid from the leaves of Annona muricata.
abstract: Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona muricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2-5). The structures of the isolated compounds were elucidated by the spectroscopic method.
authors.affiliation: Department of Xenobiotic Metabolism and Molecular Toxicology,  Graduate School of Biomedical Sciences, Hiroshima University.
authors.forename: Ayano
authors.initials: A
authors.lastname: Matsushige
authors.forename: Yaichiro
authors.initials: Y
authors.lastname: Kotake
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ohta
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D029061:Annonaceae / Q000737:chemistry; D001060:Aporphines / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001060:Aporphines; C572642:annonamine; C081279:aporphine