title: Iron deposition of the deep grey matter in patients with multiple sclerosis and neuromyelitis optica: a control quantitative study by 3D-enhanced susceptibility-weighted angiography (ESWAN).
abstract: OBJECTIVE
  Previous studies have detected abnormal iron deposition in the deep grey matter (DGM) of multiple sclerosis (MS). The regional specificity of the DGM iron deposition in neuromyelitis optica (NMO) is still unclear. We compared the differences in the DGM iron concentration between MS and NMO patients.
  
  
  METHODS
  We enrolled 42 relapsing-remitting MS (RRMS) patients, 42 NMO patients and 42 healthy controls undergoing brain conventional MRI and three-dimensional (3D)-enhanced T(2)*-weighted angiography (ESWAN) sequences. We obtained the mean phase values (MPVs) for ESWAN-filtered phase images. An analysis of covariance (ANCOVA) was used to compare MPVs among three groups. The correlations of MPVs changes with disease duration and expanded disability status scale (EDSS) were analyzed.
  
  
  RESULTS
  The RRMS patients had higher DGM iron concentration than did the NMO and control groups, but only the bilateral substantia nigra (SN) showed a significant statistical difference among three groups (p<0.05). In the RRMS group, the iron concentration in the bilateral head of the caudate nucleus (HCN) (left: p<0.0001; right: p=0.0134) and the dentate nucleus (DN) (p<0.05 for both) were correlated with disease duration. In the NMO group, no correlation was found between the DGM iron concentration and disease duration (p>0.05). Furthermore, no correlations were found between the DGM iron concentration and EDSS (p>0.05).
  
  
  CONCLUSIONS
  We confirm the iron concentration in the DGM iron content of MS patients is more than NMO patients and healthy controls in the same age range. Furthermore, the disease duration was found to be a significant contributor to patients with MS.
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. martha860831@sina.com
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.forename: Chun
authors.initials: C
authors.lastname: Zeng
authors.forename: Tianyou
authors.initials: T
authors.lastname: Luo
authors.forename: Yu
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Fajin
authors.initials: F
authors.lastname: Lv
authors.forename: Reshiana
authors.initials: R
authors.lastname: Rumzan
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Jingjie
authors.initials: J
authors.lastname: Wang
authors.forename: Huanxin
authors.initials: H
authors.lastname: Hou
authors.forename: Fuhong
authors.initials: F
authors.lastname: Huang
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007501:Iron / Q000032:analysis*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D009471:Neuromyelitis Optica / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D007501:Iron