title: Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.
abstract: Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages, and their IC(50) values ranged from 9.85 to 13.95 μg/ml.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
authors.forename: Junju
authors.initials: J
authors.lastname: Xu
authors.forename: Changjiu
authors.initials: C
authors.lastname: Ji
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Ninghua
authors.initials: N
authors.lastname: Tan
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D005638:Fruit / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D045787:Sesquiterpenes, Eudesmane; D009569:Nitric Oxide