title: [Unusual skin alterations in a 72-year-old patient with multiple myeloma].
abstract: We report on a 72-year-old female patient with multiple myeloma who presented with alopecia and eye-catching alterations of the skin and the nails. A biopsy of the skin could confirm the diagnosis of immunoglobulin light chain (AL) amyloidosis, which was also suspected of having affected other organs. After six cycles of a cytoreductive therapy with bortezomib and dexamethasone a very good partial response of the multiple myeloma was seen and an improvement in the skin and nail alterations could be achieved.
authors.affiliation: Abteilung für Hämatologie und Internistische Onkologie, Klinik für Innere Medizin I, Universitätsklinikum Regensburg. christina.hart@klinik.uni-regensburg.de
authors.forename: C
authors.initials: C
authors.lastname: Hart
authors.forename: S
authors.initials: S
authors.lastname: Wurm
authors.forename: C
authors.initials: C
authors.lastname: Hafner
authors.forename: R
authors.initials: R
authors.lastname: Andreesen
authors.forename: M
authors.initials: M
authors.lastname: Grube
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D011719:Pyrazines / Q000008:administration & dosage; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone