title: [GABA-ergic system and GABA-based drugs for regulation of immunogenesis].
abstract: The review summarizes available data about the influence of GABA-ergic substances on the immune system functional activity under both normal and pathology conditions. Analysis of information in the literature and publications shows that positive/inhibitory effects of GABA and its derivatives on the immune system depend on the overall background organism condition, as well as on parameters such as the level of antigenic stress. In addition, it is shown that changes in the immune reactivity achieved through the GABA-ergic system are dopamine and serotonin dependent. The immunotropic action of GABA and GABA-ergic substances is evidently determined by activating effect upon the multi-level immunogenesis control system, in particular, the GABA-sensitive receptors of the central nervous system and immunocompetent organs, as well as hypothalamo-pituitary-adrenal complex.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: M A
authors.initials: MA
authors.lastname: Samotrueva
authors.forename: T K
authors.initials: TK
authors.lastname: Serezhnikova
mesh_terms: D004298:Dopamine / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects*; D056747:Immunomodulation; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000276:immunology; D018079:Receptors, GABA / Q000276:immunology* / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000276:immunology* / Q000378:metabolism
chemical_list: D018755:GABA Agonists; D018756:GABA Antagonists; D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine