title: A pilot study of nimotuzumab combined with cisplatin and 5-FU in patients with advanced esophageal squamous cell carcinoma.
abstract: OBJECTIVE
  To observe the short-term effect and adverse reaction of Nimotuzumab in combination with chemotherapy on advanced esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  19 patients were treated with the following protocol: Nimotuzumab 400mg/time/week in the 1(st) week, 200mg/time/week from the 2(nd) to 8(th) week, intravenous drip (IVD); Cisplatin 80 mg/m(2), IVD, 4 weeks a cycle and repeated again; 5-FU 750 mg/m(2), continuous 24-hours pump-in × 5 days, 4 weeks a cycle and repeated again.
  
  
  RESULTS
  16 of all 19 patients can be evaluated. After treatment, RP is 42.1% (95% CI, 19.9-64.3%) and DCR is 68.4%; the main side effects include arrest of bone marrow, gastrointestinal reactions, asthenia, etc.
  
  
  CONCLUSIONS
  Nimotuzumab in combination with cisplatin/5-FU regimens in patients with advanced ESCC is safe and effective, which deserves a further expanded sample research.
authors.affiliation: Department of Oncology, Changzhou Cancer Hospital, Affiliated of Soochow University, Changzhou 213001;
authors.forename: Yang
authors.initials: Y
authors.lastname: Ling
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Tao
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chu
authors.forename: Xizhi
authors.initials: X
authors.lastname: Zhang