title: [IAPs: a central element in the NF-κB activating signaling pathway].
abstract: The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.
authors.affiliation: Inserm UMR 866, Faculté de Médecine, Université de Bourgogne, 7, Boulevard Jeanne d'Arc, 21079 Dijon Cedex, France.
authors.forename: Jessy
authors.initials: J
authors.lastname: Cartier
authors.forename: Arthur
authors.initials: A
authors.lastname: Marivin
authors.forename: Jean
authors.initials: J
authors.lastname: Berthelet
authors.forename: Laurence
authors.initials: L
authors.lastname: Dubrez
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D004249:DNA Damage; D029721:Drosophila Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008322:Mammals; D008957:Models, Genetic; D058990:Molecular Targeted Therapy; D005810:Multigene Family; D016328:NF-kappa B / Q000502:physiology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D051034:Inhibitor of Apoptosis Proteins; D016328:NF-kappa B; D009363:Neoplasm Proteins; D018124:Receptors, Tumor Necrosis Factor; D016212:Transforming Growth Factor beta; D014764:Viral Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein