title: [Malaria and HIV infection in subSaharan Africa: another match made in hell?].
abstract: Malaria and HIV are the most important infections in subSaharan Africa, in terms of the morbidity and mortality they cause. Current data suggest a possible interaction between the two diseases. Cellular immunodeficiency due to HIV infection might increase the frequency and severity of malaria, as local populations in endemic areas become less resistant. Likewise, the onset and repetition of malaria episodes might activate HIV replication and thus decrease the number of CD4 lymphocytes and accelerate the disease course. Despite their geographical coincidence, the epidemiological profiles of malaria and HIV differ considerably. The entanglement of these two diseases has epidemiological, clinical and therapeutic consequences in subSaharan Africa that raise concerns that HIV with malaria, as with tuberculosis, is a match made in Hell.
authors.affiliation: CHU Treichville Service des Maladies Infectieuses et Tropicales BP V3 Abidjan Côte d'Ivoire. ebaaoussi@hotmail.com
authors.forename: Eba François
authors.initials: EF
authors.lastname: Aoussi
authors.forename: Koffi Aristophane
authors.initials: KA
authors.lastname: Tanon
authors.forename: Eboi
authors.initials: E
authors.lastname: Ehui
authors.forename: Songda Ismaèl
authors.initials: SI
authors.lastname: Ouattara
authors.forename: Kokou André
authors.initials: KA
authors.lastname: Inwoley
authors.forename: Koffi Daho
authors.initials: KD
authors.lastname: Adoubryn
authors.forename: Serge Paul
authors.initials: SP
authors.lastname: Eholié
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bissagnéné
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000962:Antimalarials / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D018890:Chemoprevention; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000469:parasitology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D015662:Trimethoprim, Sulfamethoxazole Drug Combination