title: The impact of plant-pathogen studies on medicinal drug discovery.
abstract: The pharmaceutical industry is reliant on a constant supply of new chemical entities and molecular targets for disease intervention. In this tutorial review, we want to illustrate that basic research studies on the biological function of natural products involved in plant-pathogen interactions can serve as an inspiring source for the identification of new bioactive entities as well as of strategies on how to achieve small molecule manipulation of biological systems. An application of findings from plant-pathogen interaction studies might therefore display a significant impact on drug discovery.
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany. christian.ottmann@cgc.mpg.de
authors.forename: Christian
authors.initials: C
authors.lastname: Ottmann
authors.forename: Renier A L
authors.initials: RA
authors.lastname: van der Hoorn
authors.forename: Markus
authors.initials: M
authors.lastname: Kaiser
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D032701:Biomimetics / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D010935:Plant Diseases / Q000276:immunology; D057865:Plant Immunity; D010944:Plants / Q000276:immunology / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001688:Biological Products; D054852:Small Molecule Libraries