title: Papillary tumor of the pineal region: ultrastructural study of a case.
abstract: Papillary tumor of the pineal region (PTPR) is a recently classified neuroepithelial tumor for which there has been little comprehensive ultrastructural study. Here, we describe the radiographic, intraoperative, histologic, immunohistochemical, and in-depth ultrastructural findings in a case of PTPR. This study corroborates that PTPR has concomitant ependymal, neuroendocrine, and secretory features, and details novel ultrastructural as well as immunohistochemical features that further this argument. Discrepancies with prior descriptions of PTPR are described, as these differences may reflect phenotypic variability in this rare tumor, and the ultrastructural features that relate to the putative ependymal origin of the entity are emphasized.
authors.affiliation: Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Cykowski
authors.forename: Eric P
authors.initials: EP
authors.lastname: Wartchow
authors.forename: Gary W
authors.initials: GW
authors.lastname: Mierau
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Stolzenberg
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Gumerlock
authors.forename: Kar-Ming
authors.initials: KM
authors.lastname: Fung
mesh_terms: D000368:Aged; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D046529:Microscopy, Electron, Transmission; D018302:Neoplasms, Neuroepithelial / Q000378:metabolism / Q000648:ultrastructure*; D010871:Pinealoma / Q000378:metabolism / Q000648:ultrastructure*; D020542:Third Ventricle / Q000378:metabolism / Q000648:ultrastructure