title: A zipcode unzipped.
abstract: RNA-binding proteins (RBPs) exert many roles in the post-transcriptional regulation of gene expression in eukaryotic cells. However, our understanding of how they recognize their target RNAs in vivo remains limited. In the January 1, 2012, issue of Genes & Development, Patel and colleagues (p. 43-53) provide detailed mechanistic insights into how one of the best-studied RBPs, zipcode-binding protein 1 (ZBP1), recognizes a bipartite RNA sequence element within the β-actin mRNA.
authors.affiliation: Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Doyle
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kiebler
mesh_terms: D000818:Animals; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D012333:RNA, Messenger