title: Predictors of response to ziprasidone: results from a 6-week randomized double-blind, placebo-controlled trial for acute depressive mixed state.
abstract: BACKGROUND
  The present study is aimed at investigating possible predictors of response to ziprasidone in a sample of patients with mixed depressive state.
  
  
  METHODS
  72 patients were randomized to either ziprasidone or placebo and treated prospectively for 6 weeks. The clinical response and remission were defined with various clinical variables including Montgomery Asberg Depression Rating Scale. Further outcome measures included predictors of remission and other clinical variables over time.
  
  
  RESULTS
  None of the variables under investigation were significantly associated with response or remission at 6 weeks (all p-values>0.003, respectively).
  
  
  CONCLUSIONS
  Further investigations are warranted due to clear limitations, mostly small sample size and use of concomitant medications.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC, USA.
authors.forename: C-U
authors.initials: CU
authors.lastname: Pae
authors.forename: A A
authors.initials: AA
authors.lastname: Patkar
authors.forename: W
authors.initials: W
authors.lastname: Gilmer
authors.forename: N
authors.initials: N
authors.lastname: Holtzman
authors.forename: S B
authors.initials: SB
authors.lastname: Thommi
authors.forename: S N
authors.initials: SN
authors.lastname: Ghaemi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone