title: Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy.
abstract: Minocycline, a tetracycline family antibiotic, is known to inhibit microglial activation and proinflammatory cytokine release in animal models. Experimental data show that these immune processes may play a role in epilepto- and ictogenesis. We present the case of a patient with marked reduction in seizure frequency during minocycline therapy with severe symptomatic epilepsy due to an astrocytoma.
authors.affiliation: Epilepsy Center Hessen, Department of Neurology, Philipps-University Marburg, Baldingerstr. 1, 35033 Marburg, Germany. nowakm@med.uni-marburg.de
authors.forename: M
authors.initials: M
authors.lastname: Nowak
authors.forename: A
authors.initials: A
authors.lastname: Strzelczyk
authors.forename: P S
authors.initials: PS
authors.lastname: Reif
authors.forename: K
authors.initials: K
authors.lastname: Schorlemmer
authors.forename: S
authors.initials: S
authors.lastname: Bauer
authors.forename: B A
authors.initials: BA
authors.lastname: Norwood
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: F
authors.initials: F
authors.lastname: Rosenow
authors.forename: H
authors.initials: H
authors.lastname: Strik
authors.forename: H M
authors.initials: HM
authors.lastname: Hamer
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001254:Astrocytoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications
chemical_list: D000927:Anticonvulsants; D008911:Minocycline