title: N-Acylethanolamines and related compounds: aspects of metabolism and functions.
abstract: N-Acylethanolamines (NAE) are fatty acid derivates that are linked with an ethanolamine group via an amide bond. NAE can be characterized as lipid mediators in the plant and animal kingdoms owing to the diverse functions throughout the eukaryotic domain. The functions of NAE have been widely investigated in animal tissues in part due to their abilities to interact with the cannabinoid receptors, vanilloid receptors or peroxisome proliferator activated receptors. However, the interest of studying the functions of these lipids in plants is progressively becoming more apparent. The number of publications about the functions related to NAE and to structural analogs (homoserine lactone and alkamides) is greatly increasing, showing the importance of these lipids in various plant physiological processes. This review sheds light on their role in different processes such as seedling development, plant pathogen interaction, phospholipase D alpha inhibition and senescence of cut flowers, and underlines the interaction between NAE and NAE-related molecules with plant hormone signaling. The different metabolic pathways promoting the synthesis and degradation of NAE are also discussed, in particular the oxygenation of polyunsaturated N-acylethanolamines, which leads to NAE-oxylipins, a new family of bioactive lipids.
authors.affiliation: Laboratoire de Biogenèse Membranaire, Univ. de Bordeaux, UMR 5200, F-33000 Bordeaux, France. denis.coulon@ipb.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Coulon
authors.forename: Lionel
authors.initials: L
authors.lastname: Faure
authors.forename: Magali
authors.initials: M
authors.lastname: Salmon
authors.forename: Valerie
authors.initials: V
authors.lastname: Wattelet
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bessoule
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism; D004983:Ethanolamines / Q000737:chemistry / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010944:Plants / Q000276:immunology / Q000378:metabolism; D036226:Seedlings / Q000254:growth & development / Q000378:metabolism
chemical_list: D004983:Ethanolamines; C022203:N-acylethanolamines; D000040:Abscisic Acid; D010100:Oxygen