title: Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients.
abstract: BACKGROUND
  Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events.
  
  
  OBJECTIVE
  We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function.
  
  
  METHODS
  We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria.
  
  
  RESULTS
  Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = -0.223, P = 0.03) and fasting blood glucose (r = -0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD.
  
  
  CONCLUSIONS
  MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients.
authors.affiliation: Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Bai
authors.forename: Xuan
authors.initials: X
authors.lastname: Lai
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Zhang
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Lu
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Tian
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Fan
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose