title: Long-pulsed 1064-nm Nd:YAG laser significantly improves keratosis pilaris: a randomized, evaluator-blind study.
abstract: BACKGROUND
  Keratosis pilaris (KP) is a very common disorder; yet, very few treatment options are available.
  
  
  OBJECTIVE
  To evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser for the treatment of KP.
  
  
  METHODS
  Eighteen patients with untreated KP on the upper outer arms were enrolled in a randomized clinical trial. One arm was treated with long-pulsed 1064-nm Nd:YAG laser at 30 msec pulse width and fluence of 34 J/cm(2), while the contralateral arm served as control. Patients received three consecutive treatments at 4-week intervals. Three blinded dermatologists assessed digital photographs using a quartile grading system to separately rate global improvement, erythema and the number of keratotic papules.
  
  
  RESULTS
  Seventeen patients completed the study. There were statistically significant improvements in global assessment, erythema and the number of keratotic papules at 4 weeks after the last treatment (p < 0.05). All patients also stated that their lesions improved and were satisfied with the laser treatment.
  
  
  CONCLUSIONS
  Long-pulsed 1064-nm Nd:YAG laser has been shown to improve KP in Thai patients compared with control after three treatment sessions.
authors.affiliation: Department of Medicine, Division of Dermatology, Chulalongkorn University, Faculty of Medicine, Bangkok, Thailand.
authors.forename: Pichai
authors.initials: P
authors.lastname: Saelim
authors.forename: Marisa
authors.initials: M
authors.lastname: Pongprutthipan
authors.forename: Suwimon
authors.initials: S
authors.lastname: Pootongkam
authors.forename: Vorapicha
authors.initials: V
authors.lastname: Jariyasethavong
authors.forename: Pravit
authors.initials: P
authors.lastname: Asawanonda
mesh_terms: D000015:Abnormalities, Multiple / Q000503:physiopathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D007644:Darier Disease / Q000503:physiopathology / Q000601:surgery*; D004890:Erythema / Q000503:physiopathology; D005138:Eyebrows / Q000002:abnormalities / Q000503:physiopathology; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome; D055815:Young Adult