title: A randomized controlled trial of fractional laser therapy and dermabrasion for scar resurfacing.
abstract: BACKGROUND
  Dermabrasion has been the standard resurfacing procedure for postsurgical scars, but recovery can be long. Fractionated carbon dioxide (CO2 ) laser is a safe, effective tissue resurfacing modality, but no prospective trial has compared its safety or efficacy with that of dermabrasion for postsurgical scar resurfacing.
  
  
  OBJECTIVE
  To compare the safety and efficacy of single-treatment fractional photothermolysis with that of single-treatment dermabrasion for postsurgical scar resurfacing on the face.
  
  
  METHODS
  A split-scar method was used to compare fractionated CO2 laser and diamond fraise dermabrasion on postsurgical scars of the face. Primary endpoint was safety at day 0, 1 week, and 1 month. Secondary endpoint was efficacy at 3 months as measured by blinded evaluation of standardized photographs.
  
  
  RESULTS
  Safety data revealed that there was less erythema (p = .001) and bleeding (p = .001) at day 0, less erythema (p = .01) and edema (p = .046) at 1 week, and a trend toward less erythema at 1 month (p = .06) with fractionated CO2 . Efficacy data at 3 months revealed equivalent scar improvements (p = .77).
  
  
  CONCLUSIONS
  Fractionated CO2 laser therapy should be considered a safe alternative for surgical scar resurfacing on the face. The safety profile exceeds that of dermabrasion, and it has a quicker clinical recovery and equivalent cosmetic efficacy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA. jjc3y@virginia.edu
authors.forename: J
authors.initials: J
authors.lastname: Jared Christophel
authors.forename: Courtney
authors.initials: C
authors.lastname: Elm
authors.forename: Bart T
authors.initials: BT
authors.lastname: Endrizzi
authors.forename: Peter A
authors.initials: PA
authors.lastname: Hilger
authors.forename: Brian
authors.initials: B
authors.lastname: Zelickson
mesh_terms: D002921:Cicatrix / Q000601:surgery*; D003869:Dermabrasion / Q000379:methods*; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged