title: Understanding recent trends in incidence of invasive breast cancer in Norway: age-period-cohort analysis based on registry data on mammography screening and hormone treatment use.
abstract: OBJECTIVE
  To quantify the separate contributions of menopausal hormone treatment and mammography screening activities on trends in incidence of invasive breast cancer between 1987 and 2008.
  
  
  METHODS
  Population study using aggregated data analysed by an extended age-period-cohort model.
  
  
  METHODS
  Norway. Population Norwegian women aged 30-90 between 1987 and 2008, including 50,102 newly diagnosed cases of invasive breast cancer. Main outcomes measures Attributable proportions of mammography screening and hormone treatment to recent incidence of invasive breast cancer, and the remaining variation in incidence after adjustment for mammography screening and hormone treatment.
  
  
  RESULTS
  The incidence of invasive breast cancer in Norway increased steadily until 2002, levelled off, and then declined from 2006. All non-linear changes in incidence were explained by use of hormone treatment and mammography screening activities, with about similar contributions of each factor. In 2002, when the incidence among women aged 50-69 was highest, an estimated 23% of the cases in that age group could be attributed to mammography screening and 27% to use of hormone treatment.
  
  
  CONCLUSIONS
  Changes in incidence trends of invasive breast cancer since the early 1990s may be fully attributed to mammography screening and hormone treatment, with about similar contributions of each factor.
authors.affiliation: Department of Etiological Research, Cancer Registry of Norway, Institute of Population-based Cancer Research, PO Box 5313 Majorstuen, 0304 Oslo, Norway. harald.weedon-fekjaer@kreftregisteret.no
authors.forename: Harald
authors.initials: H
authors.lastname: Weedon-Fekjær
authors.forename: Kjersti
authors.initials: K
authors.lastname: Bakken
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Vatten
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D055088:Early Detection of Cancer / Q000379:methods / Q000639:trends; D005260:Female; D020249:Hormone Replacement Therapy / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008327:Mammography / Q000706:statistics & numerical data*; D008403:Mass Screening / Q000379:methods / Q000639:trends; D008593:Menopause; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data*