title: An outbreak of Salmonella serotype Typhimurium infections with an unusually long incubation period.
abstract: A 1998 investigation of an outbreak of Salmonella serotype Typhimurium infections among children tasting unpasteurized milk during tours of a dairy farm demonstrated a distribution of unusually long incubation periods (median, 8 days; interquartile range [IQR], 6-14 days). Bacterial isolates were highly acid tolerant and contained genes associated with protection against destructive phagocytic reactive oxygen intermediates. We hypothesize that exposure to low-dose oral inoculum of a pathogen with these properties could have contributed to cases of non-typhoidal salmonellosis with the longest incubation period reported to the Centers for Disease Control and Prevention (CDC).
authors.affiliation: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. zud4@cdc.gov
authors.forename: John T
authors.initials: JT
authors.lastname: Brooks
authors.forename: Bela T
authors.initials: BT
authors.lastname: Matyas
authors.forename: John
authors.initials: J
authors.lastname: Fontana
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: DeGroot
authors.forename: Larry R
authors.initials: LR
authors.lastname: Beuchat
authors.forename: Michael
authors.initials: M
authors.lastname: Hoekstra
authors.forename: Cindy R
authors.initials: CR
authors.lastname: Friedman
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002487:Centers for Disease Control and Prevention, U.S.; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003612:Dairying / Q000331:legislation & jurisprudence; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D055256:Infectious Disease Incubation Period; D007881:Legislation, Food; D008404:Massachusetts / Q000453:epidemiology; D050296:Microbial Viability; D008875:Middle Aged; D008892:Milk / Q000382:microbiology; D012478:Salmonella Food Poisoning / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification* / Q000472:pathogenicity*; D014481:United States; D055815:Young Adult