title: In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae.
abstract: The photoprotective potential against UVB radiation of extracts obtained from 21 commercial macroalgae from the Phyla Ochrophyta and Rhodophyta, was evaluated in vivo, using the zebrafish embryo as a whole model organism. Our results showed that the phenolic extracts from Macrocystis pyrifera and Porphyra columbina exhibited the highest photoprotective activity, close to complete photoprotection (100%), similar to that obtained for the carrageenophytes Sarcothalia radula and Gigartina skottsbergii. Under the assayed conditions, the extracts were safe and non-toxic to the embryos at a concentration of 0.04 mg/ml PGE.
authors.affiliation: Department of Pharmacology, University of Alcalá, Alcalá de Henares, and Dermatology Service, Hospital Ramon y Cajal, Madrid, Spain. maria.guinea@uah.es
authors.forename: María
authors.initials: M
authors.lastname: Guinea
authors.forename: Virginia
authors.initials: V
authors.lastname: Franco
authors.forename: Lidia
authors.initials: L
authors.lastname: Araujo-Bazán
authors.forename: Iván
authors.initials: I
authors.lastname: Rodríguez-Martín
authors.forename: Salvador
authors.initials: S
authors.lastname: González
mesh_terms: D000818:Animals; D008386:Marine Biology; D058086:Microalgae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000302:isolation & purification; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays; D015027:Zebrafish / Q000196:embryology
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D011837:Radiation-Protective Agents