title: Enhancement of naturally acquired immunity against malaria by drug use.
abstract: Combination of chemoprophylaxis with chloroquine and so-called 'controlled human malaria infections' has been shown to induce sustained and fully protective immunity against malaria in experimental settings. This opens possibilities of translating this approach into an effective and applicable strategy for the field. We review the different ways in which antimalarial drugs have been used for prevention of malaria in endemic settings and discuss the possibilities and challenges of applying a strategy of drug use and naturally acquired infection in the field.
authors.affiliation: Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands.
authors.forename: Else M
authors.initials: EM
authors.lastname: Bijker
authors.affiliation: Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sauerwein
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage*; D018890:Chemoprevention / Q000379:methods*; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology* / Q000517:prevention & control; D014611:Vaccination / Q000379:methods
chemical_list: D000962:Antimalarials