title: The immune modulation of Bacillus cereus var. Toyoi in mice immunized with experimental inactivated Bovine Herpesvirus Type 5 vaccine.
abstract: In recent years, there been significant progress toward develop more efficient vaccines. Different compounds with adjuvant capacity have been tested; however, no compound has emerged that suitable for universal use. Several efforts have been made to produce effective vaccines against Bovine herpesvirus 5 (BoHV-5), an important cattle pathogen. In this study we examine the use the probiotic Bacillus cereus var. Toyoi as a potential adjuvant to improve BoHV-5 vaccine efficacy. We observed in the supplemented animals a systemic enhanced IgG antibody response toward Th1, and increased IFN-γ, IL-12 and IL-10 cytokines mRNA levels. These results suggest that this probiotic could provide a promising means of improving vaccine efficacy, particularly those vaccines that rely on a cell-mediated immune response.
authors.affiliation: Faculdade de Veterinária, UFPel, Pelotas, RS, Brazil.
authors.forename: Talita Bandeira
authors.initials: TB
authors.lastname: Roos
authors.forename: Ana Paula de Souza Stori
authors.initials: AP
authors.lastname: de Lara
authors.forename: Luana Alves
authors.initials: LA
authors.lastname: Dummer
authors.forename: Geferson
authors.initials: G
authors.lastname: Fischer
authors.forename: Fábio Pereira Leivas
authors.initials: FP
authors.lastname: Leite
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001409:Bacillus cereus / Q000276:immunology*; D005260:Female; D015870:Gene Expression; D025881:Herpesvirus 5, Bovine / Q000276:immunology*; D022283:Herpesvirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000494:pharmacology*
chemical_list: D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines; D007074:Immunoglobulin G; D007155:Immunologic Factors; D016753:Interleukin-10; D018664:Interleukin-12; D007371:Interferon-gamma