title: Anti-glycation effect of gold nanoparticles on collagen.
abstract: Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including anti-inflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3 ± 4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.
authors.affiliation: Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
authors.forename: Ji-hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Chung-Oui
authors.initials: CO
authors.lastname: Hong
authors.forename: Yun-chang
authors.initials: YC
authors.lastname: Koo
authors.forename: Hee-Don
authors.initials: HD
authors.lastname: Choi
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Lee
mesh_terms: D003094:Collagen / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D006031:Glycosylation; D006046:Gold / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D017127:Glycation End Products, Advanced; D006046:Gold; D003094:Collagen