title: Effects of a 3-hour sleep delay on sleep homeostasis in alcohol dependent adults.
abstract: OBJECTIVE
  This study evaluated slow wave activity homeostatic response to a mild sleep challenge in alcohol-dependent adults compared to healthy controls.
  
  
  METHODS
  Participants maintained a 23:00-06:00 schedule for 5 days verified by actigraphy and diary, followed by 3 nights in the lab: adaptation, baseline, and a sleep delay night with an 02:00-09:00 schedule.
  
  
  METHODS
  Sleep ' Chronophysiology laboratory.
  
  
  METHODS
  48 alcohol-dependent adults (39 men, 9 women) who were abstinent for at least 3 weeks and 16 healthy control adults (13 men, 3 women), 21-55 years of age participated in study.
  
  
  METHODS
  N/A.
  
  
  RESULTS
  Slow wave EEG activity (SWA) in consecutive NREM periods was compared between baseline and sleep delay nights and between AD and HC groups, using age and sex as statistical covariates. The AD group showed a blunted SWA response to sleep delay with significantly lower SWA power than the HC group. Exponential regression analyses confirmed lower asymptotic SWA with a slower decay rate over NREM sleep time in the AD group. Results were similar for raw SWA and %SWA on the delay night expressed relative to baseline SWA.
  
  
  CONCLUSIONS
  Alcohol dependence is associated with impaired SWA regulation and a blunted response to a mild homeostatic sleep challenge.
authors.affiliation: University of Michigan Department of Psychiatry, Sleep & Chronophysiology Laboratory, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109-2700, USA. rosearmi@umich.edu
authors.forename: Roseanne
authors.initials: R
authors.lastname: Armitage
authors.forename: Robert
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Deirdre A
authors.initials: DA
authors.lastname: Conroy
authors.forename: J Todd
authors.initials: JT
authors.lastname: Arnedt
authors.forename: Kirk J
authors.initials: KJ
authors.lastname: Brower
mesh_terms: D056044:Actigraphy / Q000379:methods / Q000706:statistics & numerical data; D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology*; D000704:Analysis of Variance; D004569:Electroencephalography; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods / Q000706:statistics & numerical data; D012890:Sleep; D012892:Sleep Deprivation / Q000150:complications* / Q000503:physiopathology*; D013995:Time; D055815:Young Adult