title: Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice.
abstract: Using the R6/1 mouse model of Huntington disease (HD), we have recently shown that voluntary physical activity was able to correct the depressive-like behaviours exhibited by the HD animals at a pre-motor symptomatic stage of the disease. Using the high performance liquid chromatography system, we have now evaluated the effect of exercise on monoamine metabolism in HD mice. We found that serotonin and its metabolite as well as dopamine and noradrenaline were reduced across several brain regions in female R6/1 animals. Our data also suggest that some of these neurochemical deficits were modulated by physical activity, in a genotype-region dependent manner. These newly identified changes could account for some of the behavioural effects of exercise previously reported in HD mice.
authors.affiliation: Postdoctoral Research Fellow at Neural Plasticity Group, Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne, Australia;  Research Assistant, addiction and depression Group, Center for Psychiatry and Neuroscience, INSERM U894, University Pierre and Marie Curie, Paris, France;  Head, addiction and depression Group, Center for Psychiatry and Neuroscience, INSERM U894, University Pierre and Marie Curie, Paris, France. and  Head, Neural Plasticity Group, Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne.
authors.forename: Thibault
authors.initials: T
authors.lastname: Renoir
authors.forename: Caroline
authors.initials: C
authors.lastname: Chevarin
authors.forename: Laurence
authors.initials: L
authors.lastname: Lanfumey
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Hannan