title: Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp.
abstract: Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Haiying
authors.initials: H
authors.lastname: Wang
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Zhu
authors.forename: Lingmei
authors.initials: L
authors.lastname: Sun
authors.forename: Lining
authors.initials: L
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Li
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Liu
authors.forename: Zuntian
authors.initials: Z
authors.lastname: Zhao
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010569:Perylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010569:Perylene