title: Changes in apoptosis and cell proliferation in human pineal gland during aging.
abstract: Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and long-living individuals its intensity decreases.
authors.affiliation: Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical Sciences, Russia.
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: S A
authors.initials: SA
authors.lastname: Pichugin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D010870:Pineal Gland / Q000166:cytology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53