title: Effects of hypertonic dextrose on injured rat skeletal muscles.
abstract: OBJECTIVE
  Histological examination of proliferative therapy effects on the healing process of muscular injury.
  
  
  METHODS
  We performed this study between March and August 2002 at Ankara University, School of Medicine, Laboratory of Animal Experiments, Ankara, Turkey. We used an experimental animal model by conducting a standardized cut injury of the gastrocnemius muscle in 30 adult male albino rats, which we divided into 2 groups; proliferative therapy group and control group. We evaluated the injured rat muscles by light microscopy on the fifth, eight, and twelfth day of injury.
  
  
  RESULTS
  The muscular regeneration process began at day 5 in both the control and proliferative therapy groups. The proliferative therapy group revealed a prominent inflammatory reaction, fibroblast migration, and necrosis with accompanying regeneration and excessive connective tissue formation.
  
  
  CONCLUSIONS
  We cannot consider proliferative therapy an appropriate treatment modality for muscular injuries, unless there is evidence of normal muscle physiology and biomechanics post traumatically.
authors.affiliation: Department of Sport Medicine, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Kunduracioglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Ulkar
authors.forename: Bizden T
authors.initials: BT
authors.lastname: Sabuncuoglu
authors.forename: Belgin
authors.initials: B
authors.lastname: Can
authors.forename: Kenan
authors.initials: K
authors.lastname: Bayrakci