title: Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study.
abstract: The wood of the plant Sesbania sesban, is reported to have antinociceptive activity. To validate its folk use in the treatment of pain, wood was extracted successively with petroleum ether, chloroform, ethyl acetate, ethanol, and water to produce respective extracts. The extracts (50 and 100 mg/kg, ip) were screened for antinociceptive activity using hot plate test and acetic acid-induced writhing test in mice. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose-dependent activity in both the tests. In order to find out the involvement of opioid receptors, effect of naloxone (1 mg/kg, sc) on the action of extracts was checked in hot plate test. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose dependant antinociceptive activity. The antinociceptive action of the extracts was blocked by naloxone, suggesting involvement of opioid receptors in the action.
authors.affiliation: Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni, 413 736, India. nirmalsunil@rediffmail.com
authors.forename: S A
authors.initials: SA
authors.lastname: Nirmal
authors.forename: J H
authors.initials: JH
authors.lastname: Bairagi
authors.forename: A N
authors.initials: AN
authors.lastname: Patil
authors.forename: S C
authors.initials: SC
authors.lastname: Pal
authors.forename: C D
authors.initials: CD
authors.lastname: Upasani
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011957:Receptors, Opioid / Q000378:metabolism; D049931:Sesbania / Q000737:chemistry*; D014934:Wood / Q000737:chemistry*
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D011957:Receptors, Opioid; D019342:Acetic Acid