title: Seizure detection using the phase-slope index and multichannel ECoG.
abstract: Detection and analysis of epileptic seizures is of clinical and research interest. We propose a novel seizure detection and analysis scheme based on the phase-slope index (PSI) of directed influence applied to multichannel electrocorticogram data. The PSI metric identifies increases in the spatio-temporal interactions between channels that clearly distinguish seizure from interictal activity. We form a global metric of interaction between channels and compare this metric to a threshold to detect the presence of seizures. The threshold is chosen based on a moving average of recent activity to accommodate differences between patients and slow changes within each patient over time. We evaluate detection performance over a challenging population of five patients with different types of epilepsy using a total of 47 seizures in nearly 258 h of recorded data. Using a common threshold procedure, we show that our approach detects all of the seizures in four of the five patients with a false detection rate less than two per hour. A variation on the global metric is proposed to identify which channels are strong drivers of activity in each patient. These metrics are computationally efficient and suitable for real-time application.
authors.affiliation: Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA. rana.puneet@gmail.com
authors.forename: Puneet
authors.initials: P
authors.lastname: Rana
authors.forename: John
authors.initials: J
authors.lastname: Lipor
authors.forename: Hyong
authors.initials: H
authors.lastname: Lee
authors.forename: Wim
authors.initials: W
authors.lastname: van Drongelen
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kohrman
authors.forename: Barry
authors.initials: B
authors.lastname: Van Veen
mesh_terms: D000293:Adolescent; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012640:Seizures / Q000175:diagnosis*; D012680:Sensitivity and Specificity