title: Size and subclasses of low-density lipoproteins in patients with obstructive sleep apnea.
abstract: Patients with obstructive sleep apnea (OSA) have proatherogenic dyslipidemia. We analyzed predictors of low-density lipoproteins' (LDLs) size in patients with OSA. In a cross-sectional study including 58 participants with OSA (30 without the metabolic syndrome [MetS] and 28 with MetS), we evaluated the size of LDL by gradient gel electrophoresis. Compared with patients without the MetS, those with MetS showed lower LDL size (P = .007), due to a reduction in large LDL-I particles (P = .002) and an increase in small, dense LDL-IIIA (P = .048) and LDL-IIIB (P = .037). The size of LDL correlated inversely with age (r = -.268, P = .042) and serum triglycerides (r = -.364, P = .005), and positively with serum high-density lipoprotein cholesterol levels (r = .335, P = .010). In multiple regression analysis, the presence of the MetS was the only independent predictor of LDL size (P = 0.015). In patients with OSA, MetS is an independent predictor of LDL size and subclasses, whereas the severity of OSA does not contribute independently to alterations in LDL phenotype.
authors.affiliation: 1Department of Respiratory Medicine and Tuberculosis, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital, Kosice, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Sopkova
authors.forename: Kaspar
authors.initials: K
authors.lastname: Berneis
authors.forename: Manfredi
authors.initials: M
authors.lastname: Rizzo
authors.forename: Giatgen A
authors.initials: GA
authors.lastname: Spinas
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Dorkova
authors.forename: Radovan
authors.initials: R
authors.lastname: Tisko
authors.forename: Ruzena
authors.initials: R
authors.lastname: Tkacova
mesh_terms: D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications
chemical_list: D008077:Lipoproteins, LDL