title: Evaluation of a multi-element treatment center for early psychosis in the United States.
abstract: OBJECTIVE
  A growing body of research has demonstrated the potential for comprehensive, phase-specific care to improve clinical and functional outcomes in early psychosis. However, there have been no evaluations of such treatment models in the United States (US). This study is a naturalistic, prospective 1-year follow-up of an early psychosis cohort treated in one of the first US-based multi-element treatment centers.
  
  
  METHODS
  Participants were 163 individuals treated at the Outreach and Support Intervention Services (OASIS) clinic, a multi-element treatment center for early psychosis. Data were collected as part of routine care at 6-month intervals. Primary outcomes included role functioning and involvement in work or school.
  
  
  RESULTS
  Over the course of 1 year of treatment, individuals experienced significant improvements in positive and negative symptoms, role functioning, and global functioning. The proportion of individuals meeting symptom remission and functional remission criteria increased significantly from baseline to 1 year, as did the proportion of individuals attending school. There were also trend-level reductions in substance abuse.
  
  
  CONCLUSIONS
  This study provides preliminary support for the efficacy of comprehensive early intervention services in the US.
authors.affiliation: Department of Psychology, University of North Carolina, Chapel Hill, NC, USA. suzenoff@unc.edu
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Uzenoff
authors.forename: David L
authors.initials: DL
authors.lastname: Penn
authors.forename: Karen A
authors.initials: KA
authors.lastname: Graham
authors.forename: Sylvia
authors.initials: S
authors.lastname: Saade
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Smith
authors.forename: Diana O
authors.initials: DO
authors.lastname: Perkins
mesh_terms: D000293:Adolescent; D000328:Adult; D000554:Ambulatory Care Facilities; D014150:Antipsychotic Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003191:Comprehensive Health Care / Q000379:methods; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008605:Mental Health Services / Q000458:organization & administration*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D011787:Quality of Health Care; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents