title: Differential diagnosis between benign  and malignant ulcers: 320-row CT virtual  gastroscopy.
abstract: OBJECTIVE
  This study aims to assess the diagnostic accuracy of virtual gastroscopy obtained by 320-row computed tomography (CT) examination in differentiating benign from malignant gastric ulcers (GUs).
  
  
  METHODS
  49 patients (30 M, 19 F, mean age 58.6) with endoscopic and histological diagnosis of GU underwent CT examination. A hypotonizing drug was administered and gastric walls were distended by air in order to perform virtual endoscopy. Based on morphological features, GUs were subdivided into benign or malignant forms by two blinded radiologists. Interobserver agreement was evaluated using Cohen’s kappa (κ) test. CT results were then compared with endoscopic and histological findings, having the latter as the reference standard.
  
  
  RESULTS
  Thirty-five out of 49 patients (71%) were affected by malignant ulcers, while in the remaining 14 cases diagnosis of benign GU was made. Virtual gastroscopy showed diagnostic accuracy, sensitivity, and specificity values of 94%, 91%, and 100%, respectively, in differentiating benign from malignant ulcers. Almost perfect agreement between the two readers was found (κ = 0.86).
  
  
  CONCLUSIONS
  CT virtual gastroscopy improves the identification of GUs and allows differentiating benign from malignant forms.
authors.affiliation: D.I.M.-Interdisciplinary Department of Medicine, Section of Radiology, University of Bari Medical School, Piazza Giulio Casare 11, Bari, Italy. marco.moschetta@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Moschetta
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Scardapane
authors.forename: Michele
authors.initials: M
authors.lastname: Telegrafo
authors.forename: Valentina
authors.initials: V
authors.lastname: Lorusso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Angelelli
authors.forename: Amato Antonio
authors.initials: AA
authors.lastname: Stabile Ianora
mesh_terms: D002985:Clinical Protocols; D003937:Diagnosis, Differential; D005260:Female; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013276:Stomach Ulcer / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods