title: Adipose tissue as a potential source of hematopoietic stem/progenitor cells.
abstract: It has been more than 30 years since adipose tissue (AT) has been recognized as a central modulator orchestrating sophisticated process termed "immunometabolism". Nonetheless, despite its unique involvement in the regulation of immune and endocrine homeostasis, recent studies demonstrated that AT also contains significant number of hematopoietic stem/progenitor cells (HSPCs) that may be there "settling down" throughout life. In this article we will focus on presenting the current concepts regarding endocrine, immunological, and molecular mechanisms that may contribute to and regulate bone marrow (BM)-derived HSPCs homing into AT environment, as well as, highlight various structural and morphological similarities between BM and AT that might be involved in creating appropriate tissue niches for BM-derived HSPCs in AT. Finally, we will discuss how development of obesity or type 2 diabetes may influence balance of homing signals for HSPCs in AT environment.
authors.affiliation: Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland. drannab@wp.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Błogowski
authors.forename: Mariusz Z
authors.initials: MZ
authors.lastname: Ratajczak
authors.forename: Ewelina
authors.initials: E
authors.lastname: Zyżniewska-Banaszak
authors.forename: Barbara
authors.initials: B
authors.lastname: Dołęgowska
authors.forename: Teresa
authors.initials: T
authors.lastname: Starzyńska
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D001854:Bone Marrow Cells / Q000378:metabolism*; D002450:Cell Communication; D002465:Cell Movement; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction