title: Effect of ADA1 mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA.
abstract: OBJECTIVE
  To study the effect Adenosine Deaminase locus 1 (ADA(1)) mother-fetus and wife-husband phenotypic differences on the ratio Birth Weight/Placental Weight (BW/PW) in fertile women and on reproductive success in couples with repeated spontaneous abortion (RSA).
  
  
  METHODS
  209 couples with primary RSA and a consecutive series of 379 healthy puerperae with their newborn infants from the White Caucasian population of central Italy were studied. In primary RSA women reproductive success was indicated by the presence of at least one live-born infant within 5 years of follow up. Two way contingency tables were analyzed by chi-square.
  
  
  RESULTS
  The proportion of primary RSA couples with at least a live-born infant shows the highest value in couples mother ADA(1)1/father carrier of ADA(1)*2 allele (55.2%) and the lowest value in reciprocal couples mother carrier of ADA(1)*2 allele /father ADA(1)1 (18.7%) (O.R. = 5.33; P = 0.023). The highest ratio BW/PW is observed in the class mother ADA(1)1/newborn carrier of ADA(1)*2 allele while the lowest ratio is observed in the reciprocal class mother carrier of ADA(1)*2 allele/ newborn ADA(1)1.
  
  
  CONCLUSIONS
  Differences between mother and fetus in ADA(1) phenotype may influence the ratio BW/PW in healthy women and reproductive success in RSA women.
authors.affiliation: Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy. gloria@med.uniroma2.it
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
authors.forename: Maria
authors.initials: M
authors.lastname: Nicotra
authors.forename: Ada
authors.initials: A
authors.lastname: Amante
authors.forename: Sara
authors.initials: S
authors.lastname: Ambrosi
authors.forename: Eliana
authors.initials: E
authors.lastname: Cozzoli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Saccucci
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics* / Q000276:immunology; D000243:Adenosine Deaminase / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D000328:Adult; D001724:Birth Weight / Q000235:genetics*; D005260:Female; D005298:Fertility / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D010641:Phenotype; D010920:Placenta; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D018454:Spouses
chemical_list: D000243:Adenosine Deaminase