title: From cholera to burns: a role for oral rehydration therapy.
abstract: According to the practice guidelines of the American Bum Association on burn shock resuscitation, intravenous (i.v.) fluid therapy is the standard of care for the replacement of fluid and electrolyte losses in burn injury of > or = 20% of the total body surface area. However, in mass burn casualties, i.v. fluid resuscitation may be delayed or unavailable. Oral rehydration therapy (ORT), which has been shown to be highly effective in the treatment of dehydration in epidemics of cholera, could be an alternate way to replace fluid losses in burns. A prospective case series of three patients was carried out as an initial step to establish whether oral Ceralyte 90 could replace fluid losses requiring i.v. fluid therapy in thermal injury. The requirement of the continuing i.v. fluid therapy was reduced by an average of 58% in the first 24 hours after the injury (range 37-78%). ORT may be a feasible alternative to i.v. fluid therapy in the resuscitation of burns. It could also potentially save many lives in mass casualty situations or in resource-poor settings where i.v. fluid therapy is not immediately available. Further studies are needed to assess the efficacy of this treatment and to determine whether the present formulations of ORT for cholera need modification.
authors.affiliation: Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA. smilner3@jhmi.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Milner
authors.forename: W B
authors.initials: WB
authors.lastname: Greenough
authors.forename: M E
authors.initials: ME
authors.lastname: Asuku
authors.forename: M
authors.initials: M
authors.lastname: Feldman
authors.forename: R
authors.initials: R
authors.lastname: Makam
authors.forename: D
authors.initials: D
authors.lastname: Noppenberger
authors.forename: L A
authors.initials: LA
authors.lastname: Price
authors.forename: M
authors.initials: M
authors.lastname: Prosciak
authors.forename: I N
authors.initials: IN
authors.lastname: van Loon
mesh_terms: D000328:Adult; D002056:Burns / Q000628:therapy*; D002771:Cholera / Q000628:therapy*; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome