title: PPARs: fatty acid sensors controlling metabolism.
abstract: The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation. The receptors bind and are activated by a broad range of fatty acids and fatty acid derivatives and they thereby serve as major transcriptional sensors of fatty acids. Here we review the function, regulation, and mechanism of the different PPAR subtypes with special emphasis on their role in the regulation of lipid metabolism.
authors.affiliation: University of Southern Denmark, Department of Biochemistry and Molecular Biology, Campusvej 55, DK-5230, Odense M, Denmark. larscp@bmb.sdu.dk
authors.forename: Lars la Cour
authors.initials: Ll
authors.lastname: Poulsen
authors.forename: Majken
authors.initials: M
authors.lastname: Siersbæk
authors.forename: Susanne
authors.initials: S
authors.lastname: Mandrup
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D005227:Fatty Acids; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms