title: Flavone is efficient to protect zebrafish fins from UV-induced damage.
abstract: We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
authors.affiliation: Department of Chemistry, Tamkang University, Tamsui, New Taipei City, Taiwan.
authors.forename: I-Ting
authors.initials: IT
authors.lastname: Tsai
authors.forename: Zhi-Shiang
authors.initials: ZS
authors.lastname: Yang
authors.forename: Zi-Yu
authors.initials: ZY
authors.lastname: Lin
authors.forename: Chi-Chung
authors.initials: CC
authors.lastname: Wen
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Cheng
authors.forename: Yau-Hung
authors.initials: YH
authors.lastname: Chen
mesh_terms: D058500:Animal Fins / Q000187:drug effects* / Q000528:radiation effects*; D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D002599:Chalcone / Q000737:chemistry / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology*; D020287:In Situ Nick-End Labeling; D053208:Kaplan-Meier Estimate; D015394:Molecular Structure; D016016:Proportional Hazards Models; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D017382:Reactive Oxygen Species / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014466:Ultraviolet Rays; D015027:Zebrafish / Q000196:embryology*
chemical_list: D044950:Flavanones; D047309:Flavones; D017382:Reactive Oxygen Species; D002599:Chalcone; C043562:flavone; C028610:flavanone