title: Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions.
abstract: Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.
authors.affiliation: School of Natural Sciences, University of California, Merced, CA 95343, USA. mkitazawa@ucmerced.edu
authors.forename: Masashi
authors.initials: M
authors.lastname: Kitazawa
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Medeiros
authors.forename: Frank M
authors.initials: FM
authors.lastname: Laferla
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic