title: [The Collaborative Cross, a groundbreaking tool to tackle complex traits].
abstract: Complex traits, like the susceptibility to common diseases, are controlled by numerous genomic regions which individual effect is generally weak. These observations led geneticists to develop an experimental system to dissect the genetic of complex traits in the mouse. The Collaborative Cross (CC) is a genetic reference population of over 300 inbred lines derived from eight inbred strains of three Mus musculus sub-species that captures 90% of the genetic variation known in the mouse genome. We present here the generation and the characteristics of the CC and we report the results of the first experiments with partially inbred CC lines.
authors.affiliation: Génétique Fonctionnelle de la Souris, URA CNRS 2578, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France. panthier@pasteur.fr
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Panthier
authors.forename: Xavier
authors.initials: X
authors.lastname: Montagutelli
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000235:genetics; D003241:Consanguinity; D003433:Crosses, Genetic; D004777:Environment; D005106:Exploratory Behavior; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D023281:Genomics; D006720:Homozygote; D007391:International Cooperation; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci; D012015:Reference Standards; D012958:Societies, Scientific