title: Increased signal transducer and activator of transcription 3 (STAT3) and decreased cyclin D1 in recurrent astrocytic tumours compared with paired primary astrocytic tumours.
abstract: This study compared the levels of signal transducer and activator of transcription 3 (STAT3) and cyclin D1 protein in paired primary and recurrent astrocytic tumours, and analysed their correlation with clinicopathological and treatment factors. A total of 48 samples from 24 patients  who had undergone surgical removal of primary and recurrent astrocytic tumours were analysed. Levels of STAT3 and cyclin D1 protein were detected using immunohistochemistry. Increased STAT3 and decreased cyclin D1 levels were observed in recurrent astrocytic tumours compared with their paired  primary tumours. There was a significant correlation between higher levels of STAT3 protein and shorter progression-free survival in primary tumours after surgery (r = 0.417), and a significant correlation between decreased cyclin D1 protein levels and radiotherapy in recurrent tumours  (r = 0.468). It was concluded that increased STAT3 and decreased cyclin D1 protein levels may contribute to the recurrence of astrocytic tumours. Detection of STAT3 may be useful in predicting progressionfree survival in primary astrocytic tumours after surgery. In addition, radiotherapy  may decrease cyclin D1 levels in astrocytic tumours, but the nature of this association requires further investigation.
authors.affiliation: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: K
authors.initials: K
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Pang
authors.forename: T
authors.initials: T
authors.lastname: Xin
authors.forename: X
authors.initials: X
authors.lastname: Hou
authors.forename: J
authors.initials: J
authors.lastname: Jia
authors.forename: B
authors.initials: B
authors.lastname: Feng
authors.forename: L
authors.initials: L
authors.lastname: Meng
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Pang
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D003710:Demography; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D013194:Staining and Labeling; D055815:Young Adult
chemical_list: C530104:CCND1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D019938:Cyclin D1