title: Copper-catalyzed Petasis-type reaction: a general route to α-substituted amides from imines, acid chlorides, and organoboron reagents.
abstract: A copper-catalyzed Petasis-type reaction of imines, acid chlorides, and organoboranes to form α-substituted amides is described. This reaction does not require the use of activated imines or the transfer of special units from the organoboranes and represent a useful generalization of the Petasis reaction.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 2K6, Canada.
authors.forename: Marie S T
authors.initials: MS
authors.lastname: Morin
authors.forename: Yingdong
authors.initials: Y
authors.lastname: Lu
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Black
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Arndtsen
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D001565:Benzoates / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry
chemical_list: D000577:Amides; D001565:Benzoates; D001880:Boranes; D007097:Imines; D058115:Lewis Bases; D011725:Pyridines; D003300:Copper; C009504:4-toluic acid; C028419:cuprous chloride; C023666:pyridine