title: Pups of dams fed low-fat diet during pregnancy and lactation showed strong preference for high-fat diet to achieve optimal growth.
abstract: To investigate the causes why pups of dams fed a low-fat high-carbohydrate diet (LFD) showed a strong preference for fat, three groups of dams were fed one of three diets during pregnancy and lactation: the LFD, a control diet (CTD) or a high-fat low-carbohydrate diet (HFD). After weaning, pups of each of the three groups were divided into two equal subgroups (Pair 1 and Pair 2), for a total of six pup subgroups. Each subgroup was placed on a two-choice diet program of the LFD and the HFD (Pair 1), or the LFD and a HFDLE (with cellulose added to maintain the same energy concentration as the LFD) (Pair 2), for 3 wk. Although the energy intake of dams fed the LFD during the nursing period was lower than that of the HFD group, no significant difference in body weight was observed among the three groups. At weaning, the body weight of pups nursed by dams fed the LFD was lower than that of the other groups. In Pair 1, the HFD intake ratio of the LFD and the HFD groups during the self-selection period was higher than that of the CTD group. In Pair 2, the HFDLE intake ratio of the LFD and the CTD groups was lower than that of the HFD group. At the end of the self-selection period, no significant difference in body weight was observed among the three groups of Pair 1. However, in Pair 2, the body weight of the LFD group was lower than that of the other groups. Therefore, it was supposed that pups of dams fed the LFD showed strong preference for the HFD containing high energy in order to achieve optimal growth.
authors.affiliation: Department of Human Nutrition, Seitoku University, Matsudo, Chiba, Japan. yokon@seitoku.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Akie
authors.initials: A
authors.lastname: Sato
mesh_terms: D050154:Adiposity; D000818:Animals; D001522:Behavior, Animal; D018752:Diet, Fat-Restricted / Q000009:adverse effects*; D059305:Diet, High-Fat; D002149:Energy Intake; D005260:Female; D005518:Food Preferences; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology; D007328:Insulin / Q000097:blood; D007774:Lactation; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning; D015430:Weight Gain
chemical_list: D007328:Insulin