title: Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain-containing proteins.
abstract: In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starvation induced genes, acting to optimize Pi uptake and utilization. Among these, a subset of proteins containing the SPX domain has been shown to be key regulators of Pi homeostasis. In this review, we summarize the recent progresses in elucidating the mechanisms controlling Pi homeostasis in yeast, focusing on the key roles of the SPX domain-containing proteins in these processes, as well as describing the future challenges and opportunities in this fast-moving field.
authors.affiliation: Joint Research Laboratory in Genomics and Nutriomics, College of Life Sciences, Zhejiang University, Hangzhou, China. david.secco@uwa.edu.au
authors.forename: David
authors.initials: D
authors.lastname: Secco
authors.forename: Chuang
authors.initials: C
authors.lastname: Wang
authors.forename: Huixia
authors.initials: H
authors.lastname: Shou
authors.forename: James
authors.initials: J
authors.lastname: Whelan
mesh_terms: D000595:Amino Acid Sequence; D005800:Genes, Fungal; D006706:Homeostasis; D008954:Models, Biological; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D028061:Phosphate Transport Proteins / Q000235:genetics / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018832:Molecular Chaperones; C557524:Pho87 protein, S cerevisiae; C544652:Pho90 protein, S cerevisiae; C525960:Pho91 protein, S cerevisiae; D028061:Phosphate Transport Proteins; D010710:Phosphates; D029701:Saccharomyces cerevisiae Proteins; C499587:VTC1 protein, S cerevisiae; D033921:Vesicular Transport Proteins; D010727:Phosphoric Diester Hydrolases; C038133:glycerophosphodiester phosphodiesterase