title: D-ribose in glycation and protein aggregation.
abstract: BACKGROUND
  D-ribose is a naturally occurring pentose monosaccharide present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products (AGEs) that lead to cell dysfunction and death. As recent studies show, ribosylation, a rapid process, causes protein aggregation in vitro and in vivo.
  
  
  METHODS
  This review summarizes the relationship between ribosylation, protein aggregation, cell death and cognitive impairments.
  
  
  CONCLUSIONS
  D-ribose is active in glycation and induces protein aggregation, rapidly producing AGEs in vitro and in vivo.
  
  
  CONCLUSIONS
  Ribosylation, leading to the production of significant amounts of AGEs both extracellularly and intracellularly, may be involved in cell dysfunction and subsequent cognitive impairments. This review may be a useful reference for studies on the pharmacokinetics of D-ribose action.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Chan Shuai
authors.initials: CS
authors.lastname: Han
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Chen
authors.forename: Rong Qiao
authors.initials: RQ
authors.lastname: He
mesh_terms: D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D051379:Mice; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D012266:Ribose / Q000378:metabolism*
chemical_list: D017127:Glycation End Products, Advanced; D011506:Proteins; D012266:Ribose