title: Modulation of MMPs by cell surface integrin receptor α5β1.
abstract: MMPs are a family of Zn dependent endopeptidases, which can mediate degradation of ECM components during various physiological and pathological processes including cancer. Some ECM components, through interaction with integrin receptor and modulation of downstream signaling, are capable of regulating expression and activity of several MMPs. α₅β₁ integrin is the universally accepted receptor for the ECM component fibronectin (FN). The present review deals with the downstream signaling involved in the α₅β₁ integrin mediated modulation of expression and activity of MMPs and their effector responses in different cellular system.
authors.affiliation: Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, 37 S. P. Mukherjee Road, Kolkata-700026, West Bengal, India.
authors.forename: Sekhar
authors.initials: S
authors.lastname: Pal
authors.forename: Kirat Kumar
authors.initials: KK
authors.lastname: Ganguly
authors.forename: Shuvojit
authors.initials: S
authors.lastname: Moulik
authors.forename: Amitava
authors.initials: A
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005353:Fibronectins; D039081:Integrin alpha5beta1; D020782:Matrix Metalloproteinases