title: [Basonuclins and DISCO proteins: regulators of development in vertebrates and insects].
abstract: Basonuclins 1 and 2 are nuclear proteins specific to vertebrates. They have recently been shown to be the orthologs of the DISCO proteins of insects. All of these proteins have an essential function in embryonic development. It is likely that they are transcription factors with multiple gene targets, some of which are transcribed by DNA polymerase I, and others by polymerase II. It remains to be found which targets are common to the two basonuclins and even to the DISCO proteins, and why certain cell types possess either basonuclin 1 or basonuclin 2, while others possess both. The implication of the basonuclins in several human diseases adds to their interest as regulatory proteins.
authors.affiliation: Unité de Régulation de la Transcription et Maladies Génétiques, CNRS et Université Paris Descartes, 45, rue des Saints-Pères, 75006 Paris, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Hervé
authors.forename: Amandine
authors.initials: A
authors.lastname: Vanhoutteghem
authors.forename: Philippe
authors.initials: P
authors.lastname: Djian
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D016384:Consensus Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000737:chemistry / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D007313:Insecta / Q000196:embryology* / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology* / Q000235:genetics; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; C400212:disco protein, Drosophila