title: Flavonoid mixture analysis by matrix-assisted diffusion-ordered spectroscopy.
abstract: The structural similarity of flavonoids, often present in natural product mixtures, makes their analysis by NMR methods less than straightforward. This similarity is a dual problem for one of the most powerful NMR methods for mixture analysis, diffusion-ordered spectroscopy (DOSY), which relies both on well-resolved peaks and on differences in hydrodynamic radii for separating the signals from different components in a mixture. To overcome these limitations, we use a matrix-assisted DOSY approach that exploits differential chemical interactions with a slow diffusion matrix (here micellar sodium dodecyl sulfate) to resolve flavonoid mixtures in mixed solvents.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom. cassani@correo.xoc.uam.mx
authors.forename: Julia
authors.initials: J
authors.lastname: Cassani
authors.forename: Mathias
authors.initials: M
authors.lastname: Nilsson
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Morris
mesh_terms: D004058:Diffusion; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012967:Sodium Dodecyl Sulfate
chemical_list: D005419:Flavonoids; D012967:Sodium Dodecyl Sulfate