title: SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation.
abstract: BACKGROUND
  The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery).
  
  
  METHODS
  A total of 57 breast cancer patients who underwent SSPBI were genotyped for SNPs (single nucleotide polymorphisms) in XRCC1, XRCC3, GST and RAD51 by Pyrosequencing technology. Univariate analysis (ORs and 95% CI) was performed to correlate SNPs with the risk of developing ≥ G2 fibrosis or fat necrosis.
  
  
  RESULTS
  A higher significant risk of developing ≥ G2 fibrosis or fat necrosis in patients with: polymorphic variant GSTP1 (Ile105Val) (OR = 2.9; 95%CI, 0.88-10.14, p = 0.047).
  
  
  CONCLUSIONS
  The presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity.
  
  
  BACKGROUND
  ClinicalTrials.gov: NCT01316328.
authors.affiliation: Laboratory of Pharmacokinetic/Pharmacogenomic, Regina Elena National Cancer Institute, Rome, Italy. falvo@ifo.it
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Falvo
authors.forename: Lidia
authors.initials: L
authors.lastname: Strigari
authors.forename: Gennaro
authors.initials: G
authors.lastname: Citro
authors.forename: Carolina
authors.initials: C
authors.lastname: Giordano
authors.forename: Genoveva
authors.initials: G
authors.lastname: Boboc
authors.forename: Fabiana
authors.initials: F
authors.lastname: Fabretti
authors.forename: Vicente
authors.initials: V
authors.lastname: Bruzzaniti
authors.forename: Luca
authors.initials: L
authors.lastname: Bellesi
authors.forename: Paola
authors.initials: P
authors.lastname: Muti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
authors.forename: Paola
authors.initials: P
authors.lastname: Pinnarò
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005355:Fibrosis / Q000473:pathology; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D006801:Humans; D008875:Middle Aged; D027361:Organic Anion Transporters / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics / Q000528:radiation effects*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051135:Rad51 Recombinase / Q000235:genetics; D011878:Radiotherapy / Q000009:adverse effects*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D027361:Organic Anion Transporters; D051135:Rad51 Recombinase; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; C487009:SLCO6A1 protein, human