title: Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea.
abstract: The aim of the present study was to investigate the effect of continuous positive airway pressure (CPAP) treatment on regional adipose tissue distribution in patients with moderate or severe obstructive sleep apnoea. Patients received both therapeutic and sham CPAP in a random order for 2 months each with an intervening 1-month washout. Abdominal subcutaneous, visceral and liver fat were quantified using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Liver enzymes and plasma glucose were also determined. Measurements were obtained at baseline and at the end of both treatment arms. 38 eligible patients were randomly assigned to a treatment order, with 27 patients having complete MRI/MRS data. No significant difference was observed in subcutaneous (-28.6 cm(3); p=0.49) or visceral (-16.8 cm(3); p=0.59) adipose tissue, intrahepatic lipid (-0.2%; p=0.21), or fasting glucose measurements (-0.1 mmol·L(-1); p=0.46) between treatment modalities. Alkaline phosphatase decreased (-3.1 U·L(-1); p=0.02) while on therapeutic CPAP compared with sham CPAP but other liver enzymes, including aspartate aminotransferase (0.3 U·L(-1); p=0.82), alanine aminotransferase (1.34 U·L(-1); p=0.59) and γ-glutamyltransferase (-2.3 U·L(-1); p=0.33), remained unchanged. In this first randomised, sham-controlled trial, there was no change in adipose tissue distribution after 8 weeks of therapeutic CPAP compared with 8 weeks of sham CPAP. Longer duration of CPAP use may be necessary to demonstrate a difference.
authors.affiliation: Sleep and Circadian Research Group, Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2050, Australia. sheila.sivam@sydney.edu.au
authors.forename: Sheila
authors.initials: S
authors.lastname: Sivam
authors.forename: Craig L
authors.initials: CL
authors.lastname: Phillips
authors.forename: Michael I
authors.initials: MI
authors.lastname: Trenell
authors.forename: Brendon J
authors.initials: BJ
authors.lastname: Yee
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Liu
authors.forename: Keith K
authors.initials: KK
authors.lastname: Wong
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Grunstein
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D050218:Body Fat Distribution; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy*; D050507:Subcutaneous Fat, Abdominal