title: Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-co-glycolide) block copolymer.
abstract: Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib. Transmission electron microscopy of the sorafenib-incorporated DexbLG nanoparticles revealed a spherical shape with a diameter < 300 nm. Sorafenib-incorporated DexbLG nanoparticles at a polymer/drug weight ratio of 40:5 showed a relatively uniform size and morphology. Higher initial drug feeding was associated with increased drug content in nanoparticles and in nanoparticle size. A drug release study revealed a decreased drug release rate with increasing drug content. In an in vitro anti-proliferation assay using human cholangiocarcinoma cells, sorafenib-incorporated DexbLG nanoparticles showed a similar antitumor activity as sorafenib. Sorafenib-incorporated DexbLG nanoparticles are promising candidates as vehicles for antitumor drug targeting.
authors.affiliation: National Research & Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Republic of Korea. nanomed@naver.com.
authors.forename: Do Hyung
authors.initials: DH
authors.lastname: Kim
authors.forename: Min-Dae
authors.initials: MD
authors.lastname: Kim
authors.forename: Cheol-Woong
authors.initials: CW
authors.lastname: Choi
authors.forename: Chung-Wook
authors.initials: CW
authors.lastname: Chung
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Ha
authors.forename: Cy Hyun
authors.initials: CH
authors.lastname: Kim
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Shim
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang