title: [Association of interleukin-1 genetic polymorphism and CagA positive Helicobacter pylori with gastric cancer in Colombia].
abstract: BACKGROUND
  There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. However systematic reviews of the existing evidence have shown that such association varies across populations with different genetic ancestry.
  
  
  OBJECTIVE
  To evaluate the association of IL-1B-511 and IL-1RN polymorphism and Helicobacter pylori IgG antibodies CagA, with gastric cancer in two Colombian cities located in a high risk area for gastric cancer.
  
  
  METHODS
  A case-control study including 46 gastric cancer cases and 99 controls with non-atrophic gastritis from a high risk zone for gastric cancer. Polymorphism genotyping was carried out by polymerase chain reaction (PCR) and IgG CagA status by ELISA.
  
  
  RESULTS
  IgG CagA seropositive individuals had an increased gastric cancer risk (odds ratio (OR) = 11.56; 95% confidence intervals (CI) 2.62-50.91 in Tunja and OR = 19.66, 95%CI 0.98-395 in Bogotá). IL-1B-511TT carriers in Tunja had increased risk of gastric cancer (OR = 11.31; 95%CI 1.20-106.54)), while IL-1RN*2 alelle carriers in Bogotá showed an inverse association with gastric cancer risk (OR = 0.03; 95%CI 0.01-0.65).
  
  
  CONCLUSIONS
  This study adds evidence to the positive association of Helicobacter pylori CagA positive strains with non-cardial gastric cancer etiology. There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area.
authors.affiliation: Grupo de Investigación Epidemiológica del Cáncer, Instituto Nacional de Cancerología, Bogotá, D.E., Colombia.
authors.forename: Teresa
authors.initials: T
authors.lastname: Martínez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Hernández-Suárez
authors.forename: María Mercedes
authors.initials: MM
authors.lastname: Bravo
authors.forename: Esperanza
authors.initials: E
authors.lastname: Trujillo
authors.forename: Andrés
authors.initials: A
authors.lastname: Quiroga
authors.forename: Rosario
authors.initials: R
authors.lastname: Albis
authors.forename: Juan C
authors.initials: JC
authors.lastname: Robayo
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Bravo
authors.forename: Margarita
authors.initials: M
authors.lastname: Camorlinga
mesh_terms: D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003105:Colombia / Q000208:ethnology; D005260:Female; D016481:Helicobacter Infections / Q000235:genetics* / Q000276:immunology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; C080866:cagA protein, Helicobacter pylori