title: What is active acromegaly and which parameters do we have?
abstract: Disease activity of acromegaly can be measured in many ways. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) concentrations are the main biochemical markers used to measure the response to treatment. Both GH and IGF1 have been associated with prognosis, in particular mortality. In this review, we discuss the available parameters to assess disease activity in acromegaly.
authors.affiliation: Department of Medicine, Section Endocrinology, Erasmus University Medical Center Rotterdam, CA Rotterdam, The Netherlands. s.neggers@erasmusmc.nl
authors.forename: S J C M M
authors.initials: SJ
authors.lastname: Neggers
authors.forename: N R
authors.initials: NR
authors.lastname: Biermasz
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Lely
mesh_terms: D000172:Acromegaly / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D019382:Human Growth Hormone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; C406545:pegvisomant