title: Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols.
abstract: Polyene synthesis: An efficient approach to the total synthesis of polyene natural product dihydroxrulin (1) is described. A novel, mild, direct organocatalytic IBX-mediated dehydrogenation process of simple alcohols to enals has been developed, which serves as a key step in the synthesis (see scheme).
authors.affiliation: Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA.
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Xinshuai
authors.initials: X
authors.lastname: Zhang
authors.forename: Sihan
authors.initials: S
authors.lastname: Zhao
authors.forename: Zian
authors.initials: Z
authors.lastname: Xu
authors.forename: Xixi
authors.initials: X
authors.lastname: Song
authors.forename: Xinhong
authors.initials: X
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011090:Polyenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000438:Alcohols; D001688:Biological Products; D007783:Lactones; D011090:Polyenes; C066798:dihydroxerulin