title: In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
abstract: TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.
authors.affiliation: R. M. Alden Research Lab, Culver City, California, USA. k.l.tyrrell@att.net
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D002511:Cephalosporins / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003352:Corynebacterium / Q000187:drug effects*; D003470:Culture Media; D017576:Daptomycin / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D003470:Culture Media; D017576:Daptomycin; D006020:Glycopeptides; D014640:Vancomycin; C539430:cefilavancin