title: Coordination-driven self-assembly of ruthenium-based molecular-rectangles: synthesis, characterization, photo-physical and anticancer potency studies.
abstract: A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by (1)H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC(50) values comparable to those of cisplatin and doxorubicin.
authors.affiliation: Department of Chemistry, University of Ulsan, Ulsan, Republic of Korea.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Vajpayee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Song
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Jung
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.forename: Hyunuk
authors.initials: H
authors.lastname: Kim
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Cook
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Stang
authors.forename: Ki-Whan
authors.initials: KW
authors.lastname: Chi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004583:Electrons; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012428:Ruthenium