title: Hippocampal BDNF expression in a tau transgenic mouse model.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular accumulation of amyloid deposits and intracellular neurofibrillary tangles (NFT) composed of hyperphosphorylated Tau proteins. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor playing a critical role in hippocampal synaptic plasticity and memory and whose levels have been shown reduced in AD brains. While recent data support a pivotal role of β-amyloid peptides towards BDNF decrease, whether Tau pathology impacts on BDNF expression remains unknown so far. In the present study, we have evaluated this relationship using quantitative PCR, Western blot and ELISA in the THY-Tau22 transgenic strain, known to display a progressive development of both hippocampal AD-like Tau pathology and memory impairments. We observed that Tau pathology was not associated with down-regulation of BDNF at the protein and mRNA levels in this model, suggesting that the alteration of BDNF homeostasis observed in AD patients' brains might rather be ascribed to amyloid pathology.
authors.affiliation: Max-Planck Institute für Biologie des Alterns/Max-Planck Institute for Biology of Ageing, Köln, Germany. sylvie.burnouf@age.mpg.de
authors.forename: Sylvie
authors.initials: S
authors.lastname: Burnouf
authors.forename: Karim
authors.initials: K
authors.lastname: Belarbi
authors.forename: Laetitia
authors.initials: L
authors.lastname: Troquier
authors.forename: Maxime
authors.initials: M
authors.lastname: Derisbourg
authors.forename: Dominique
authors.initials: D
authors.lastname: Demeyer
authors.forename: Antoine
authors.initials: A
authors.lastname: Leboucher
authors.forename: Cyril
authors.initials: C
authors.lastname: Laurent
authors.forename: Malika
authors.initials: M
authors.lastname: Hamdane
authors.forename: Luc
authors.initials: L
authors.lastname: Buee
authors.forename: David
authors.initials: D
authors.lastname: Blum
mesh_terms: D000367:Age Factors; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D024801:Tauopathies / Q000235:genetics / Q000473:pathology*; D015854:Up-Regulation / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger; D016875:tau Proteins