title: Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs).
abstract: Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher's Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient's overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.
authors.affiliation: Departments of Digestive Surgery and Pathology and Centre for Researcher Support, Barretos Cancer Hospital, Pio XII Foundation, Barretos, São Paulo, Brazil. netto123@uol.com.br
authors.forename: Antônio Talvane Torres
authors.initials: AT
authors.lastname: de Oliveira
authors.forename: Céline
authors.initials: C
authors.lastname: Pinheiro
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Brito
authors.forename: Olga
authors.initials: O
authors.lastname: Martinho
authors.forename: Delcio
authors.initials: D
authors.lastname: Matos
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Carvalho
authors.forename: Vinícius Lima
authors.initials: VL
authors.lastname: Vazquez
authors.forename: Thiago Buosi
authors.initials: TB
authors.lastname: Silva
authors.forename: Cristovam
authors.initials: C
authors.lastname: Scapulatempo
authors.forename: Sarhan Sydney
authors.initials: SS
authors.lastname: Saad
authors.forename: Rui Manuel
authors.initials: RM
authors.lastname: Reis
authors.forename: Fátima
authors.initials: F
authors.lastname: Baltazar
mesh_terms: D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics; D016019:Survival Analysis; D027981:Symporters / Q000378:metabolism*; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D051926:Basigin; D014408:Biomarkers, Tumor; D027501:Monocarboxylic Acid Transporters; D048493:Proto-Oncogene Proteins B-raf; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C497886:BSG protein, human; C482119:BRAF protein, human