title: Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.
abstract: Seven new compounds (aflaquinolones A-G; 1-7) containing dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea. The structures of these compounds were determined mainly by analysis of NMR and MS data. Relative and absolute configurations were assigned on the basis of NOESY data and (1)H NMR J-values, comparison of calculated and experimental ECD spectra, and analysis of a Mosher's ester derivative of 2. Several known compounds, including alantrypinone, aspochalasins I and J, methyl 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate, and trans-dehydrocurvularin were also encountered in the extract of the Hawaiian isolate.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Neff
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Lee
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Jonas
authors.initials: J
authors.lastname: Baltrusaitis
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
authors.forename: Donald T
authors.initials: DT
authors.lastname: Wicklow
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D056911:Democratic People's Republic of Korea; D018922:HL-60 Cells; D006254:Hawaii; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification*; D013211:Staphylococcus aureus; D013237:Stereoisomerism
chemical_list: D015363:Quinolones