title: Effects of short-term oral administration of propranolol on tear secretion in clinically normal dogs.
abstract: This study evaluated the effects of short-term oral administration of propranolol on tear secretion in 15 clinically normal crossbreed dogs. The treatment group (n = 8) received propranolol (2 mg/kg q8h) orally for 7 days. The control group (n = 7) received placebo during the study. Schirmer I tear tests were performed on both eyes 1 d prior to drug administration (T(0)), at 1 (T(1)), 3 (T(3)), and 7 (T(7)) days of treatment. Tear production in dogs, measured by STT, was not significantly reduced in both groups.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, Islamic Azad University-Karaj Branch, Karaj, Iran. selkghaffari@gmail.com
authors.forename: Masoud Selk
authors.initials: MS
authors.lastname: Ghaffari
authors.forename: Vahid
authors.initials: V
authors.lastname: Arzani
authors.forename: Nargess
authors.initials: N
authors.lastname: Khorami
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Rajaei
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D013666:Tears / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol