title: Patients and partners lack knowledge of androgen deprivation therapy side effects.
abstract: OBJECTIVE
  Androgen deprivation therapy (ADT) is the primary treatment for advanced prostate cancer (CaP). There is growing evidence that ADT negatively affects men's psychosocial well-being (e.g., causing sexual dysfunction, bodily feminization) and physical health (e.g., increasing the risk of osteoporosis and metabolic syndrome). Although strategies for managing the majority of side effects exist, it is not clear that patients are benefiting from this knowledge.
  
  
  METHODS
  Seventy-nine newly prescribed ADT patients and 54 of their partners were given a checklist of various common and uncommon ADT side effects. They were asked to indicate the drug side effects that they had heard of or anticipated.
  
  
  RESULTS
  Both patients and their partners were poorly informed about the side effects of luteinizing hormone-releasing hormone (LHRH) agonists used for ADT. More than 70% did not know that anemia, memory problems, loss of body hair, and depression can occur following treatment. Over 50% were unaware of significant potential side effects such as reduced muscle mass, osteoporosis, increased fracture risk, weight gain, genital shrinkage, and gynecomastia. Concurrently, more than 20% mistakenly anticipated dizziness and itching.
  
  
  CONCLUSIONS
  The lack of awareness of ADT side effects may partially explain why ADT currently results in significant decreases in the quality of life of patients and their partners. Patients uninformed about side effects do not engage in behaviors to prevent or reduce the risk of adverse effects. Improved efforts to educate patients about treatment side effects and coping strategies may result in improved psychosocial and physical health for CaP patients undergoing ADT.
authors.affiliation: Department of Psychology, University of Calgary, Calgary, Alberta, Canada; Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Electronic address: lmwalker@ucalgary.ca.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Walker
authors.forename: Susan
authors.initials: S
authors.lastname: Tran
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wassersug
authors.forename: Bejoy
authors.initials: B
authors.lastname: Thomas
authors.forename: John W
authors.initials: JW
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000009:adverse effects*; D000740:Anemia / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced; D010353:Patient Education as Topic / Q000379:methods / Q000706:statistics & numerical data; D063046:Patient Medication Knowledge / Q000379:methods* / Q000706:statistics & numerical data*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced; D012747:Sexual Partners; D018454:Spouses; D011795:Surveys and Questionnaires
chemical_list: D000726:Androgen Antagonists