title: [CCR5-Δ32 allele involvement in the clinical evolution of HIV1+ patients in Yucatán, Mexico].
abstract: OBJECTIVE
  CCR5-Δ32 allele frequency needs to be identified in HIV+ patients and exposed seronegative individuals in Yucatan, Mexico, to understand this mutation's relationship to infection and disease progression.
  
  
  METHODS
  A total of 355 samples were analyzed: 62 from HIV+ patients, 51 from exposed seronegative individuals and 242 from general population. Infected patients were subdivided into a) normal progressors n= 49; b) slow progressors n= 10, and c) non-progressors n= 3.
  
  
  RESULTS
  Genotype wt/Δ32 was identified in 17.7% of HIV+, 13.7% of exposed seronegative individuals and 6.2% of general population. Genotype Δ32/Δ32 was identified in 3.9% of exposed seronegative individuals. In infected patients, wt/Δ32 was identified in 10.2% of normal progressors, 30% of slow progressors and 100% of non-progressors.
  
  
  CONCLUSIONS
  Genotype wt/Δ32 was observed in all non-progressing HIV+ patients, supporting its role in this group's disease development and clinical evolution.
authors.affiliation: Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Yucatán, México. valadez@uady.mx
authors.forename: Nina
authors.initials: N
authors.lastname: Valadez-González
authors.forename: Pedro
authors.initials: P
authors.lastname: González-Martínez
authors.forename: Dora
authors.initials: D
authors.lastname: Lara-Perera
authors.forename: Ligia
authors.initials: L
authors.lastname: Vera-Gamboa
authors.forename: Renán
authors.initials: R
authors.lastname: Góngora-Biachi
mesh_terms: D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D018023:HIV Seronegativity / Q000235:genetics; D006679:HIV Seropositivity / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D011446:Prospective Studies; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology
chemical_list: D019713:Receptors, CCR5