title: Association of SLC6A4 gene 5-HTTLPR polymorphism with parameters of simple and complex reaction times and critical flicker frequency threshold in athletes during exhaustive exercise.
abstract: The incidence of SLC6A4 gene 5HTTLPR polymorphism alleles was evaluated in 223 male athletes engaged in endurance sports, the results were compared with those in 177 male nonathletes. Association between 5-HTTLPR genotypes and the effect of exhaustive treadmill running on simple and complex visual reactions and critical flicker frequency threshold was studied. We found that the incidence of LL genotype was significantly higher in athletes in comparison to nonathletes; after exercise, the velocity of visual reactions and critical flicker frequency increased; exercise did not change the velocity of complex visual reaction in LL-carriers, and increased it in SS-carriers. We conclude that exhausting treadmill running leads to facilitation sensory information processing in athletes and that SS-carriers are more susceptible to the effect of exhaustive treadmill running than LL-carriers.
authors.affiliation: Russian Research Institute of Sport and Physical Education, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Trushkin
authors.forename: M A
authors.initials: MA
authors.lastname: Timofeeva
authors.forename: O V
authors.initials: OV
authors.lastname: Sysoeva
authors.forename: Y I
authors.initials: YI
authors.lastname: Davydov
authors.forename: A
authors.initials: A
authors.lastname: Knicker
authors.forename: H
authors.initials: H
authors.lastname: Struder
authors.forename: A G
authors.initials: AG
authors.lastname: Tonevitsky
mesh_terms: D000328:Adult; D056352:Athletes; D015444:Exercise / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011930:Reaction Time / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins