title: Vascular disrupting agent arsenic trioxide enhances thermoradiotherapy of solid tumors.
abstract: Our previous studies demonstrated arsenic trioxide- (ATO-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors. These results suggested that a trimodality approach of radiation, ATO, and local hyperthermia may have potent therapeutic efficacy against solid tumors. Here, we report the antitumor effect of hypofractionated radiation followed by ATO administration and local 42.5 °C hyperthermia and the effects of cisplatin and thermoradiotherapy. We found that the therapeutic efficacy of ATO-based thermoradiotherapy was equal or greater than that of cisplatin-based thermoradiotherapy, and marked evidence of in vivo apoptosis and tumor necrosis were observed in ATO-treated tumors. We conclude that ATO-based thermoradiotherapy is a powerful means to control tumor growth by using vascular disruption to augment the effects of thermal and radiation therapy.
authors.affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot No. 824, Little Rock, AR 72205, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Griffin
authors.forename: Brent W
authors.initials: BW
authors.lastname: Williams
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Koonce
authors.forename: John C
authors.initials: JC
authors.lastname: Bischof
authors.forename: Chang W
authors.initials: CW
authors.lastname: Song
authors.forename: Rajalakshmi
authors.initials: R
authors.lastname: Asur
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Upreti