title: Synthesis and singlet oxygen reactivity of 1,2-diaryloxyethenes and selected sulfur and nitrogen analogs.
abstract: 1,2-Diaryloxyethene has recently been proposed as a linker in singlet oxygen-mediated drug release. Even though 1,2-diaryloxyethenes look very simple, their synthesis was not an easy task. Previous methods are limited to symmetric molecules, lengthy step and low yield. We report on a facile synthetic method not only for 1,2-diaryloxyethenes but also their sulfur and nitrogen analogs in yields ranging from 40 to 90% with more than 90% purity at the vinylation reaction.
authors.affiliation: Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Nkepang
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Pogula
authors.forename: Moses
authors.initials: M
authors.lastname: Bio
authors.forename: Youngjae
authors.initials: Y
authors.lastname: You
mesh_terms: D005030:Ethylenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009584:Nitrogen / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013455:Sulfur / Q000737:chemistry*
chemical_list: D005030:Ethylenes; D026082:Singlet Oxygen; D013455:Sulfur; D009584:Nitrogen