title: Chlorinated englerins with selective inhibition of renal cancer cell growth.
abstract: The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).
authors.affiliation: Natural Products Support Group, SAIC-Frederick National Cancer Institute, Frederick, Maryland 21702, United States.
authors.forename: Rhone K
authors.initials: RK
authors.lastname: Akee
authors.forename: Tanya
authors.initials: T
authors.lastname: Ransom
authors.forename: Ranjala
authors.initials: R
authors.lastname: Ratnayake
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007668:Kidney; D007680:Kidney Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D054547:National Cancer Institute (U.S.); D029803:Phyllanthus / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism; D013636:Tanzania; D014481:United States
chemical_list: C571986:2'-chloroenglerin A; D000972:Antineoplastic Agents, Phytogenic; D006843:Hydrocarbons, Chlorinated; D045789:Sesquiterpenes, Guaiane; C534971:englerin A; C551614:englerin B