title: Treatment of multifocal Bowen's disease in immunocompromised women with surgery and topical imiquimod.
abstract: BACKGROUND
  In human immunodeficiency virus (HIV)-infected women, Bowen's disease may be difficult to treat successfully with surgery alone. Imiquimod cream, effective in treating Bowen's disease in healthy women, may be a useful postsurgical treatment in immunocompromised women.
  
  
  METHODS
  Two HIV-infected women had both Bowen's disease and severe cervical dysplasia. In both cases, Bowen's disease, but not cervical dysplasia, recurred after surgical treatment. When treated with topical 5% imiquimod cream twice weekly for 4 months, 70-80% reduction in lesions were observed in both patients. Follow-up biopsies of remaining lesions were vulvar intraepithelial neoplasia 1.
  
  
  CONCLUSIONS
  Imiquimod cream, in combination with surgical treatment, may be an appropriate strategy for treatment of Bowen's disease in HIV-infected and other immunocompromised women.
authors.affiliation: From the Hematology Branch, National Heart, Lung, and Blood Institute, the Medical Genetics Branch, National Human Genome Research Institute, the Intramural Office of Rare Diseases, Office of the Director, and the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
authors.forename: Suhasini
authors.initials: S
authors.lastname: Kaushal
authors.forename: Melissa
authors.initials: M
authors.lastname: Merideth
authors.forename: Pallavi
authors.initials: P
authors.lastname: Kopparthy
authors.forename: Tajana Klepac
authors.initials: TK
authors.lastname: Pulanic
authors.forename: Pamela
authors.initials: P
authors.lastname: Stratton
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D000077271:Imiquimod; D016867:Immunocompromised Host; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000601:surgery; D014846:Vulvar Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000601:surgery
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod