title: [Keratin fragments as a serological indicator in patients with a liver disease].
abstract: BACKGROUND
  Determination of M30 antigen appears to be a sensitive method for evaluation of hepatocyte apoptosis. The aim of the present project was to implement this technique, compare M30 values in patients with a liver disease and healthy controls and to identify potential relationships between M30 values and other parameters.
  
  
  METHODS
  M30 antigen was assessed in 25 patients with a liver disease and 30 healthy controls. These results were compared between patients with a liver disease and the controls and correlated to a range of clinical and laboratory values, including tissue polypeptide-specific antigen (TPS), in patients with a liver disease.
  
  
  RESULTS
  We found significant differences in M30 values between controls and patients with a liver disease. The only significant correlations were the correlation between M30 and ALT, highly significant correlation between M30 and AST and highly significant correlation between M30 and TPS.
  
  
  CONCLUSIONS
  The M30 antigen is a sensitive indicator of liver damage. Considering the highly significant correlation with TPS, it can be assumed that in some liver diseases, TPS could serve as a clinically useful indicator of apoptosis.
authors.affiliation: Interní klinika Lékarské fakulty Ostravské univerzity a FN Ostrava. Jan.Lata@osu.cz
authors.forename: J
authors.initials: J
authors.lastname: Lata
authors.forename: H
authors.initials: H
authors.lastname: Mrlianová
authors.forename: O
authors.initials: O
authors.lastname: Stibůrek
authors.forename: J
authors.initials: J
authors.lastname: Nozicka
authors.forename: Z
authors.initials: Z
authors.lastname: Cermáková
authors.forename: J
authors.initials: J
authors.lastname: Gottwaldová
authors.forename: P
authors.initials: P
authors.lastname: Drozd
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D053538:Keratin-18 / Q000032:analysis*; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053538:Keratin-18; C561463:M30 cytokeratin-18 peptide, human; D010446:Peptide Fragments; D010455:Peptides; C089984:tissue polypeptide specific antigen