title: The radiorecovery potential of nutraceuticals in cellular defense after ionizing radiation in vitro.
abstract: BACKGROUND
  The aim of this study was to evaluate the effects of two nutraceuticals Amazon Megamin and Immunarc forte in radiorecovery of human lymphocytes after exposure to ionizing radiation in vitro.
  
  
  METHODS
  The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined in cultured human peripheral blood lymphocytes before and after ionizing radiation in a present of nutraceuticals in vitro.
  
  
  RESULTS
  Results showed that Amazon Megamin and Immunarc forte possess antioxidant properties; they act by eliminating the toxic metabolites, scavenging the free radicals and decreasing lipid peroxidation.
  
  
  CONCLUSIONS
  The obtained results indicated that the studied nutraceuticals can help in prevention of the development of injurious caused by ionizing irradiation and, therefore, they encourage studies on their radioprotective properties.
authors.affiliation: Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: A
authors.initials: A
authors.lastname: Leskovac
authors.forename: S
authors.initials: S
authors.lastname: Petrovic
authors.forename: A
authors.initials: A
authors.lastname: Valenta-Sobot
authors.forename: I
authors.initials: I
authors.lastname: Joksic
authors.forename: M
authors.initials: M
authors.lastname: Baltic
authors.forename: L
authors.initials: L
authors.lastname: Aleksic
authors.forename: G
authors.initials: G
authors.lastname: Joksic
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D019587:Dietary Supplements; D016166:Free Radical Scavengers / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D011837:Radiation-Protective Agents