title: Autophagy in pancreatic cancer.
abstract: Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.
authors.affiliation: Parc Scientifique et Technologique de Luminy, Stress Cellulaire, INSERM U624, 163 avenue de Luminy, CP 915, 13288 Marseille Cedex 9, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grasso
authors.forename: Maria Noé
authors.initials: MN
authors.lastname: Garcia
authors.forename: Juan L
authors.initials: JL
authors.lastname: Iovanna