title: Discovery and development of N-cadherin antagonists.
abstract: This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH(2) and monoclonal antibodies directed against the N-cadherin ectodomain. The biological activities of these antagonists are also discussed. In particular, the ability of N-cadherin antagonists to act as anti-cancer drugs is considered.
authors.affiliation: Division of Urology, Department of Surgery, McGill University, Montreal, QC, Canada. orest.blaschuk@mcgill.ca
authors.forename: Orest W
authors.initials: OW
authors.lastname: Blaschuk
mesh_terms: D000595:Amino Acid Sequence; D015820:Cadherins / Q000037:antagonists & inhibitors*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D015820:Cadherins; D010455:Peptides