title: Anti-inflammatory flavonoids from Cryptocarya chingii.
abstract: Six flavonoids named cryptogiones A-F, and nine known compounds were isolated from an ethanol extract of stems of Cryptocaryachingii. The structures of the compounds were elucidated by interpretation of comprehensive spectroscopic data and X-ray analysis. A majority of these flavonoids contained an acetic acid/lactone moiety, a possible taxonomic marker. Anti-inflammatory effects of the compounds were evaluated using in vitro assays. At 20 μM concentration, three compounds significantly inhibited TNFα-induced NF-кB activation and LPS-induced IL-1β expression.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Feng
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Chun Min
authors.initials: CM
authors.lastname: Yan
authors.forename: Er Guang
authors.initials: EG
authors.lastname: Li
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015415:Biomarkers / Q000737:chemistry; D031369:Cryptocarya / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D053583:Interleukin-1beta / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008968:Molecular Conformation; D016328:NF-kappa B / Q000276:immunology; D018547:Plant Stems / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D044950:Flavanones; D005419:Flavonoids; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D016328:NF-kappa B; D011753:Pyrones; D014409:Tumor Necrosis Factor-alpha; C548572:cryptocaryone; D000431:Ethanol; C016063:pinocembrin