title: [Use of platelet concentrates: a regional experience].
abstract: OBJECTIVE
  The Établissement français du sang (EFS) distributes two types of platelet concentrates: using a single donor in aphaeresis platelet concentrate (SDAP), versus pooled platelet concentrates (PPC). A retrospective study performed by the Blood Derivatives Group at Observatory for Drugs, Medical Devices and Therapeutic Innovations (OMEDIT), in collaboration with EFS and haemovigilance correspondents from eight regional health care establishments, has analyzed platelet concentrates prescriptions and the position of the prescribers concerning PPC supply.
  
  
  METHODS
  Between the 2nd and 6th June 2008, 151 platelet concentrates were supplied by ESF. Data were collected for 144 platelet concentrates and in 83 transfused patients with an average age of 50years. During this study, 33 PPC (23%) and 111 SDAP (77%) were supplied.
  
  
  RESULTS
  With regards to the 111 SDAP, the supply of PPC was refused in 47 cases (42%), accepted in 18 cases (16%) and unknown for 46 cases (42%). A total of 51 PPC could be supplied during this period, which represented 35% of platelet concentrates prescriptions. The rate of platelets before transfusion was known for 121 platelet concentrates, the median was 32G·L(-1) for SDAP and 44G·L(-1) for PPC.
  
  
  CONCLUSIONS
  More frequent PPC use, with comparable therapeutic efficacy, could be interesting in a context of increasing platelet concentrates consumption in health care establishments. Moreover, prescribers did not seem to be against the idea. An information pamphlet on platelet concentrates was drafted and distributed to prescribers in order to promote the prescription of PPC. A second assessment is planned to measure the impact of this communication.
authors.affiliation: Observatoire du médicament, des dispositifs médicaux et de l'innovation thérapeutique (Omédit) de Haute-Normandie, CHU de Rouen, IBC 2(e) étage, 1, rue de Germont, 76031 Rouen cedex, France. elise.remy@chu-rouen.fr
authors.forename: A-S
authors.initials: AS
authors.lastname: Legendre
authors.forename: S
authors.initials: S
authors.lastname: Le Monnier
authors.forename: P
authors.initials: P
authors.lastname: Chamouni
authors.forename: A
authors.initials: A
authors.lastname: Damais
authors.forename: I
authors.initials: I
authors.lastname: Hervé
authors.forename: P
authors.initials: P
authors.lastname: Lenain
authors.forename: I
authors.initials: I
authors.lastname: Maréchal
authors.forename: P
authors.initials: P
authors.lastname: Rasonglès
authors.forename: P
authors.initials: P
authors.lastname: Breton
authors.forename: P
authors.initials: P
authors.lastname: Pavie
authors.forename: S
authors.initials: S
authors.lastname: Guirao
authors.forename: J
authors.initials: J
authors.lastname: Doucet
authors.forename: E
authors.initials: E
authors.lastname: Rémy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D055815:Young Adult