title: Testicular neoplasia in the retained testicles of an intersex male dog.
abstract: This case describes the presentation and management of an 8 yr old phenotypically female intersex male dog presented for evaluation of a mass in the right inguinal region. The right inguinal space was surgically explored, and a large irregular mass resembling a fully developed testicle was identified in the right vaginal tunic. A second mass resembling an atrophied, but anatomically mature testicle, was identified in the left tunic. The larger mass was identified as a Sertoli cell tumor that had replaced all normal testicular tissue. The smaller mass was identified as a testicle that contained a small intratubular seminoma. The patient was diagnosed as having a phenotypic female sex, chromosomal male sex, and a gonadal male sex. Hormone assays completed before and after the gonadectomy and mass removal document an elevation of circulating progesterone presurgically that returned to baseline by 1 mo postsurgically. The source of the progesterone was identified to be the Leydig cells of the atrophied testicle.
authors.affiliation: Relief Veterinary Service, Keller, TX, USA. aaron.herndon@okstate.edu
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Herndon
authors.forename: Margret L
authors.initials: ML
authors.lastname: Casal
authors.forename: John T Scott
authors.initials: JT
authors.lastname: Jaques
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D010641:Phenotype; D011374:Progesterone / Q000097:blood; D013736:Testicular Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*
chemical_list: D011374:Progesterone