title: Molecular imaging of cancer with radiolabeled peptides and PET.
abstract: Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positron-emitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed.
authors.affiliation: St. Jude Children’s Research Hospital, Molecular Imaging Research, Department of Radiological Sciences, Memphis, TN, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Vāvere
authors.forename: Raffaella
authors.initials: R
authors.lastname: Rossin
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D057054:Molecular Imaging / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010455:Peptides; D011868:Radioisotopes