title: Clinical effect of a mouth rinse containing Ocimum gratissimum on plaque and gingivitis control.
abstract: OBJECTIVE
  The effect of Ocimum gratissimum (Og) on the reduction of dental plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial.
  
  
  METHODS
  Subjects were randomly allocated to the control group (n=10)-mouth rinse with no antiseptic agents; CLX group (n=10)-mouth rinse containing chlorhexidine digluconate or Og group (n=10)-mouth rinse containing Ocimum gratissimum. Plaque (PLI) and bleeding (BI) indexes were assessed at days 0 and after 3 months. Subjects were asked to brush their teeth with a fluoridated dentifrice, three times a day, during a 90-day period. After each brushing they rinsed with one of the three mouth rinses during 1 minute.
  
  
  RESULTS
  There was a significant reduction on plaque and gingivitis in tests groups (p < 0.05), but no statistically significant difference was observed among them (p > 0.05).
  
  
  CONCLUSIONS
  Mouth rinse containing Og was effective as antiplaque and antigingivitis agent, in a similar manner that chlorhexidine digluconate.
  
  
  CONCLUSIONS
  Research in treatment of chronic oral diseases using natural agents must be encouraged to verify which would be a useful addition to the current range of chemotherapeutic treatment options.
authors.affiliation: Department of Periodontics, Dental School, University of Fortaleza, Brazil. luiss@unifor.br
authors.forename: Sérgio Luís da Silva
authors.initials: SL
authors.lastname: Pereira
authors.forename: José Weslley Gonçalves
authors.initials: JW
authors.lastname: de Oliveira
authors.forename: Keyles Karla Sá Vieira
authors.initials: KK
authors.lastname: Angelo
authors.forename: Angela Maria Alves
authors.initials: AM
authors.lastname: da Costa
authors.forename: Flávio
authors.initials: F
authors.lastname: Costa
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003773:Dental Plaque / Q000145:classification / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005891:Gingivitis / Q000145:classification / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D031339:Ocimum; D010512:Periodontal Index; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D028321:Plant Preparations; C010882:chlorhexidine gluconate; D002710:Chlorhexidine