title: Acute dialysis risk in living kidney donors.
abstract: BACKGROUND
  Reduced kidney function confers a higher risk of acute kidney injury at the time of an inciting event, such as sepsis. Whether the same is true in those with reduced renal mass from living kidney donation is unknown.
  
  
  METHODS
  We conducted a population-based matched cohort study of all living kidney donors in the province of Ontario, Canada who underwent donor nephrectomy from 1992 to 2009. We manually reviewed the medical records of these living kidney donors and linked this information to provincial health care databases. Non-donors were selected from the healthiest segment of the general population.
  
  
  RESULTS
  There were 2027 donors and 20 270 matched non-donors. The median age was 43 years (interquartile range 34-50) and individuals were followed for a median of 6.6 years (maximum 17.7 years). The primary outcome was acute dialysis during any hospital stay. Reasons for hospitalization included infectious diseases, cardiovascular diseases and hematological malignancies. Only one donor received acute dialysis in follow-up (6.5 events per 100 000 person-years), a rate which was statistically no different than 14 non-donors (9.4 events per 100 000 person-years).
  
  
  CONCLUSIONS
  These results are reassuring for the practice of living kidney donation. Longer follow-up of this and other donor cohorts will provide more precise estimates about this risk.
authors.affiliation: Department of Medicine, Division of Nephrology, University of Western Ontario, London, Canada.
authors.forename: Ngan
authors.initials: N
authors.lastname: Lam
authors.forename: Anjie
authors.initials: A
authors.lastname: Huang
authors.forename: Liane S
authors.initials: LS
authors.lastname: Feldman
authors.forename: John S
authors.initials: JS
authors.lastname: Gill
authors.forename: Martin
authors.initials: M
authors.lastname: Karpinski
authors.forename: Joseph
authors.initials: J
authors.lastname: Kim
authors.forename: Scott W
authors.initials: SW
authors.lastname: Klarenbach
authors.forename: Greg A
authors.initials: GA
authors.lastname: Knoll
authors.forename: Krista L
authors.initials: KL
authors.lastname: Lentine
authors.forename: Chris Y
authors.initials: CY
authors.lastname: Nguan
authors.forename: Chirag R
authors.initials: CR
authors.lastname: Parikh
authors.forename: G V Ramesh
authors.initials: GV
authors.lastname: Prasad
authors.forename: Darin J
authors.initials: DJ
authors.lastname: Treleaven
authors.forename: Ann
authors.initials: A
authors.lastname: Young
authors.forename: Amit X
authors.initials: AX
authors.lastname: Garg
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects; D009864:Ontario; D006435:Renal Dialysis; D012307:Risk Factors; D009927:Tissue and Organ Procurement