title: [Non-functioning pituitary adenoma: is there an interest to treat a residue after surgery?].
abstract: Diagnosis of non-functioning pituitary adenoma is generally posted when there is a compression of the ophthalmic nerve or when a hypopituitarism occurred. Surgery will be the first treatment but complete removal can be achieved in less than 50% of the patients. In the great majority of the patients, there is a recurrence and a new treatment is proposed. The question is when we must treat a residue after surgery. We performed a retrospective study reviewing a series of 111 patients with a non-functioning pituitary adenoma. All patients had a pre- and post-operative MRI (1.5 T). A statistical analysis was done to determine the influence of the resection, the age of the patient on the recurrence. A complete removal was achieved for 45 patients and 11 of these present a recurrence. 39 patients out of 66 patients who had a partial removal presented also a recurrence. The mean age of the population is 53 years. The statistical analysis demonstrates that patients with a complete removal had less recurrence. Patient with an age below 60 years had more frequently a recurrence compared with older than 60 years old. In conclusion, treatment for non-functioning pituitary adenoma is a transsphenoidal approach surgery. A complete surgery must be the aim of the neurosurgeon. And when a residue is present, a secondary treatment must be given for patient with an age below 60 years old like radiosurgery or radiation therapy.
authors.affiliation: Service de Neurochirurgie, Hôpital Erasme, Bruxelles. odewitte@ulb.ac.be
authors.forename: O
authors.initials: O
authors.lastname: De Witte
authors.forename: S
authors.initials: S
authors.lastname: Lonneville
authors.forename: D
authors.initials: D
authors.lastname: Balériaux
authors.forename: F
authors.initials: F
authors.lastname: Devuyst
authors.forename: N
authors.initials: N
authors.lastname: Massager
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D006801:Humans; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000453:epidemiology / Q000628:therapy*; D010911:Pituitary Neoplasms / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult