title: Comparison of the metabolic profiles of noncoagulating and coagulating bovine milk.
abstract: We hypothesize that, through milk composition and different milk metabolites, it is possible to characterize the technological properties (e.g., coagulation) of milk. In this research, liquid chromatography mass spectrometry was used to obtain profiles of low molecular weight organic compounds in 143 milk samples. The metabolic profiles of milk from cows were correlated with their coagulation properties. Using multivariate data analysis methods, we demonstrated that the metabolic profiles of the milk were correlated with coagulation ability. Several marker ions responsible for differential coagulation were found. Although not all affected metabolites could be identified, the most significant differences were found for carnitine and oligosaccharides. Exploitation of these results may increase the use of biomarkers to assess the coagulation ability of milk. This study represents the first large-scale metabolomic profiling of noncoagulating and coagulating bovine milk samples in Estonia.
authors.affiliation: Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 46, Tartu 51006, Estonia. hedi.harzia@emu.ee
authors.forename: H
authors.initials: H
authors.lastname: Harzia
authors.forename: K
authors.initials: K
authors.lastname: Kilk
authors.forename: I
authors.initials: I
authors.lastname: Jõudu
authors.forename: M
authors.initials: M
authors.lastname: Henno
authors.forename: O
authors.initials: O
authors.lastname: Kärt
authors.forename: U
authors.initials: U
authors.lastname: Soomets
mesh_terms: D000818:Animals; D002417:Cattle; D005223:Fats / Q000032:analysis; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D055442:Metabolome; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D008894:Milk Proteins / Q000032:analysis; D053719:Tandem Mass Spectrometry
chemical_list: D005223:Fats; D008894:Milk Proteins