title: Nonfluoride caries-preventive agents: new guidelines.
abstract: Nonfluoride caries-prevention agents have been developed and promoted to the dental profession in the recent past. The oral healthcare professional is encouraged to use evidence-based information when making clinical decisions. Recently, a systematic review was completed by a panel of experts convened by the American Dental Association Council on Scientific Affairs and recommendations were developed to address efficacy of nonfluoride agents in reducing the incidence of caries and arresting or reversing the progression of caries. The panel found that all nonfluoride agents should be used as adjuncts, following initial use of primary caries prevention strategies (fluoride, sealants, anticaries diet). This paper discusses the levels of certainty for evidence statements and clinical applications of these recommendations.
  
  
  CONCLUSIONS
  The panel concluded that certain nonfluoride agents may provide some benefits as adjunctive therapies in children and adults at higher risk of developing caries.
authors.affiliation: Graduate Dental Hygiene Division Idaho State University, Pocatello, ID, UDA. fpickett2@gmail.com
authors.forename: Frieda Atherton
authors.initials: FA
authors.lastname: Pickett
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use; D002638:Chewing Gum; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003733:Dental Caries Susceptibility; D055094:Evidence-Based Dentistry; D005247:Feeding Behavior; D005457:Fluoridation; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D017410:Practice Guidelines as Topic; D012196:Review Literature as Topic; D013402:Sugar Alcohols / Q000627:therapeutic use; D013549:Sweetening Agents / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods; D014993:Xylitol / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D002364:Caseins; D002638:Chewing Gum; D013402:Sugar Alcohols; D013549:Sweetening Agents; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides; D002710:Chlorhexidine; D014993:Xylitol