title: A rhabdomyosarcoma arising in the larynx of a dog.
abstract: A neoplastic nodular lesion, 2 × 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated cells (myotubes). Immunohistochemically, tumor cells were positive for myoglobin, desmin and vimentin in varying degrees, but negative for S-100 protein, GFAP or cytokeratin. Cytoplasmic myofilaments/myofibrils with a dense Z-line-like structure were seen, the fine structures of which were complemented by PTAH stain. Based on these findings, the tumor was diagnosed as a rhabdomyosarcoma, a very rare tumor in the larynx of dogs.
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
authors.forename: Fumi
authors.initials: F
authors.lastname: Murai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Izawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyoshi
authors.forename: Junichiro
authors.initials: J
authors.lastname: Shimizu
authors.forename: Fumihito
authors.initials: F
authors.lastname: Ohashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura