title: Results at seven years after the use of intracamerular cefazolin as an endophthalmitis prophylaxis in cataract surgery.
abstract: BACKGROUND
  To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery.
  
  
  METHODS
  A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endophthalmitis over that period were reviewed. The patients were classified in two groups: Group 1 (11,696 patients) operated on between January 1996 and December 2002, Group 2 (13,305 patients) between January 2003 and December 2009 (in whom a 1 mg/0.1 bolus of intracameral cefazolin was instilled).
  
  
  RESULTS
  During the study period, 76 cases of endophthalmitis were observed in Group 1, and seven in Group 2. The rate of postoperative endophthalmitis reduced from 0.63% to 0.05% with a cefazolin injection. The relative risk (RR) for endophthalmitis in Group 1 against group 2 was 11.45 [95% CI 5.72-22.84, p < 0.001].
  
  
  CONCLUSIONS
  An intracameral bolus injection of cefazolin (1 mg in 0.1 ml solution) at the conclusion of the cataract surgery significantly reduced the rate of postoperative endophthalmitis.
authors.affiliation: Ophthalmology Service, Hospital Universitari Sant Joan, IISPV, Universidad Rovira i Virgili, Reus, Spain. romeropere@gmail.com
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero-Aroca
authors.forename: Isabel
authors.initials: I
authors.lastname: Méndez-Marin
authors.forename: Merce
authors.initials: M
authors.lastname: Salvat-Serra
authors.forename: Juan
authors.initials: J
authors.lastname: Fernández-Ballart
authors.forename: Matias
authors.initials: M
authors.lastname: Almena-Garcia
authors.forename: Javier
authors.initials: J
authors.lastname: Reyes-Torres
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction; D002437:Cefazolin / Q000008:administration & dosage*; D009877:Endophthalmitis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007267:Injections; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin