title: Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.
abstract: Propofol is widely used for sedating critically ill adult patients because of its rapid onset and short recovery times, even after prolonged use. Propofol may be associated with a life-threatening syndrome, propofol-related infusion syndrome (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, and rhabodomyolysis. The pathophysiology is incompletely understood. Propofol-related infusion syndrome seems to be dose-related, and it occurs generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented.
authors.affiliation: Department of Anesthesiology, Ludwig-Maximilians-University Munich, D-80336 Munich, Germany. thorsten.annecke@med.uni-muenchen.de
authors.forename: Thorsten
authors.initials: T
authors.lastname: Annecke
authors.forename: Peter
authors.initials: P
authors.lastname: Conzen
authors.forename: Ludwig
authors.initials: L
authors.lastname: Ney
mesh_terms: D000138:Acidosis / Q000139:chemically induced; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D006259:Craniocerebral Trauma / Q000503:physiopathology* / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced; D013577:Syndrome; D015599:Trauma Severity Indices
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol