title: Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) study.
abstract: Genome-wide associations with glycosylated hemoglobin, which reflects the long-term glycemia, were examined using two independent cohorts of the Korea Association Resource (KARE) consortium. We first identified sequence variants within a linkage disequilibrium block (r(2) > 0.98) in the intron 5 of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene using 4,275 normoglycemic subjects of Cohort 1 (P < 2.5 × 10(-8)). The association was replicated in 3,782 normoglycemic subjects of Cohort 2. Furthermore, the sequence variants were also associated with glucose levels after oral glucose tolerance test. Especially, a strong association with 1 h glucose (P = 1.3 × 10(-11)) led us to interpreting that CDKAL1 might influence the level of glycosylated hemoglobin by affecting 1 h glucose level. Ultimately, accumulated effects on the glycosylated hemoglobin level by the genetic variation of CDKAL1 might affect susceptibility to type 2 diabetes mellitus.
authors.affiliation: School of Systems Biomedical Science, Soongsil University, Seoul, Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Ryu
authors.forename: Chaeyoung
authors.initials: C
authors.lastname: Lee
mesh_terms: D044466:Asian People / Q000235:genetics; D015331:Cohort Studies; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012359:tRNA Methyltransferases
chemical_list: D051360:Cyclin-Dependent Kinase 5; D006442:Glycated Hemoglobin; D012359:tRNA Methyltransferases; C525110:CDKAL1 protein, human