title: Pemphigus vegetans induced by use of enalapril.
abstract: Pemphigus Vegetans was first described as a variant of Pemphigus Vulgaris in 1876 by Neumann. In 1889, Hallopeau described a patient with pustules and vegetating plaques, suggesting that it would be a variant of Pemphigus Vegetans of Neumann. Both types of Pemphigus Vegetans are characterized by the development of vegetating plaques especially on skin folds (axillae, groin, perianal region). The authors present and discuss a case of Pemphigus Vegetans with an unusual clinical presentation lacking involvement of mucous membrane and flexor surfaces in an elderly female patient, associated with the use of enalapril as possible trigger factor. Clinical and histological diagnosis were suggestive of Pemphigus Vegetans of the Hallopeau type.
authors.affiliation: Institute of Dermatology Prof. Rubem David Azulay, Charity Hospital of Rio de Janeiro, Brazil. andrehricardo@gmail.com
authors.forename: André Ricardo
authors.initials: AR
authors.lastname: Adriano
authors.forename: Antonio
authors.initials: A
authors.lastname: Gomes Neto
authors.forename: Gustavo R
authors.initials: GR
authors.lastname: Hamester
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Nunes
authors.forename: Gabriella
authors.initials: G
authors.lastname: Di Giunta
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010392:Pemphigus / Q000139:chemically induced* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D004656:Enalapril; D011241:Prednisone