title: First domino radical cyclisation/Smiles rearrangement combination.
abstract: An unprecedented domino radical cyclisation-Smiles rearrangement process affording 3-(2'-aryl-N-methyl acetamido)indolin-2-ones is presented. Experimental rationalisation of this approach and description of an unexpected tricyclic core are also handled.
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 6229, Université de Reims-Champagne-Ardenne, Faculté de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims, Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pudlo
authors.forename: Ingrid
authors.initials: I
authors.lastname: Allart-Simon
authors.forename: Bernard
authors.initials: B
authors.lastname: Tinant
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gérard
authors.forename: Janos
authors.initials: J
authors.lastname: Sapi
mesh_terms: D003500:Cyclization; D007211:Indoles / Q000737:chemistry*
chemical_list: D007211:Indoles; C456900:indolin-2-one