title: Dendrimer D5 is a vector for peptide transport to brain cells.
abstract: Dendrimers are a new class of nonviral vectors for gene or drug transport. Dendrimer capacity to penetrate through the blood-brain barrier remaines little studied. Biotinylated polylysine dendrimer D5, similarly to human growth hormone biotinylated fragment covalently bound to D5 dendrimer, penetrates through the blood-brain barrier and accumulates in Drosophila brain after injection into the abdomen. Hence, D5 dendrimer can serve as a vector for peptide transport to brain cells.
authors.affiliation: B. P. Konstantinov Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad region, Gatchina, Russia. svesar1@yandex.ru
authors.forename: S V
authors.initials: SV
authors.lastname: Sarantseva
authors.forename: O I
authors.initials: OI
authors.lastname: Bolshakova
authors.forename: S I
authors.initials: SI
authors.lastname: Timoshenko
authors.forename: A A
authors.initials: AA
authors.lastname: Kolobov
authors.forename: A L
authors.initials: AL
authors.lastname: Schwarzman
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D050091:Dendrimers / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D011107:Polylysine / Q000378:metabolism
chemical_list: D050091:Dendrimers; D026901:Membrane Transport Proteins; D011107:Polylysine; C043912:peptide permease