title: Inflammatory factors in major and macular branch retinal vein occlusion.
abstract: Concentrations of inflammatory factors were measured in 40 patients with macular edema due to major branch retinal vein occlusion (BRVO) or macular BRVO who were treated by pars plana vitrectomy. Vitreous fluid levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor (PEDF) were determined. Visual acuity and central macular thickness were significantly improved at 6 months in both groups. Vitreous fluid levels of VEGF and sICAM-1 were higher in the major BRVO group than the macular BRVO group, while the PEDF level was lower in the major group than the macular group. The mean visual acuity and central macular thickness at 6 months were not significantly different between the macular and major groups. In conclusion, patients with major BRVO had higher vitreous levels of inflammatory factors and lower vitreous levels of anti-inflammatory PEDF. Accordingly, regulating inflammatory factors might be more important in major BRVO than macular BRVO.
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owada-shinden, Yachiyo, Chiba, Japan. nomahide@tymc.twmu.ac.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Eguchi
authors.forename: Katsunori
authors.initials: K
authors.lastname: Shimada
mesh_terms: D000368:Aged; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008269:Macular Edema / Q000378:metabolism / Q000601:surgery; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D012170:Retinal Vein Occlusion / Q000378:metabolism* / Q000601:surgery; D015843:Serpins / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D018799:Intercellular Adhesion Molecule-1; D009414:Nerve Growth Factors; D015843:Serpins; D042461:Vascular Endothelial Growth Factor A; D000099174:Pigment Epithelium-Derived Factor; C467484:VEGFA protein, human