title: D-dimer as a potential prognostic marker.
abstract: Malignant tumors are often accompanied by increased risk for procoagulant activity, thrombosis and embolism. As a marker indicating such disturbancies is D-dimer, a product of fibrinolysis. In this retrospective study almost 300 patients with malignant tumors were evaluated. During LMWH treatment (as thromboprophylaxis) the highest frequency of VTE with worst prognosis occurred in pancreatic cancer (partly due to the late discovery) followed by ovarian, colonic and breast cancers. Also, increased D-dimer level correlated with progression (stages) and high mortality rate. Furthermore, D-dimer showed very similar or better prognostic activity than the clinically widely used classic tumor markers and suggested to use it as an additional value..
authors.affiliation: Department Clinical Oncology, St Imre Hospital, Tétényi út 12-15, 1116 Budapest, Hungary. zsulacz@chello.hu
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Nagy
authors.forename: Orsolya
authors.initials: O
authors.lastname: Horváth
authors.forename: Julia
authors.initials: J
authors.lastname: Kádas
authors.forename: Dorottya
authors.initials: D
authors.lastname: Valtinyi
authors.forename: Larisza
authors.initials: L
authors.lastname: László
authors.forename: Bence
authors.initials: B
authors.lastname: Kopper
authors.forename: György
authors.initials: G
authors.lastname: Blaskó
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D054556:Venous Thromboembolism / Q000188:drug therapy / Q000209:etiology
chemical_list: D000925:Anticoagulants; D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products; D006495:Heparin, Low-Molecular-Weight; C036309:fibrin fragment D