title: Towards a healthy human model of neural disorders of movement.
abstract: A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.
authors.affiliation: Institute for Neural Computation, University of California-San Diego, La Jolla, CA 92093, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Poizner
authors.forename: Jack
authors.initials: J
authors.lastname: Lancaster
authors.forename: Eugene
authors.initials: E
authors.lastname: Tunik
authors.forename: Shalini
authors.initials: S
authors.lastname: Narayana
authors.forename: Crystal
authors.initials: C
authors.lastname: Franklin
authors.forename: William
authors.initials: W
authors.lastname: Rogers
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Donald A
authors.initials: DA
authors.lastname: Robin
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D002540:Cerebral Cortex / Q000502:physiology; D003627:Data Interpretation, Statistical; D005260:Female; D020233:Gait Disorders, Neurologic / Q000503:physiopathology*; D006225:Hand / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009048:Motor Skills / Q000502:physiology; D009068:Movement / Q000502:physiology; D038361:Neuronavigation / Q000295:instrumentation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D014584:User-Computer Interface