title: [Elevation of proinflammatory cytokines level at early age as the risk factor of neurological and mental pathology development].
abstract: Proinflammatory cytokines Interleukin-1, Interleukin-6 (IL-1, IL-6) and tumour necrosis factor alpha (TNFalpha), the key mediators of neuroimmune interactions, are the common pathogenic part of various kinds of the perinatal pathology leading to severe neurological and mental diseases. In the review, features of expression of the proinflammatory cytokines and their receptors in the brain at early age under normal and pathological conditions, their influence on processes of maturing of the CNS cells are described, the data of experimental and clinical researches of disturbances of the mental functions arising in adults owing to elevation of the IL-1, IL-6 levels and TNFalpha in early ontogenesis are cited. The role of the cytokines in pathogenesis of schizophrenia, a syndrome of attention deficiency, autism and a Parkinsonism is discussed.
authors.forename: O E
authors.initials: OE
authors.lastname: Zubarev
authors.forename: V M
authors.initials: VM
authors.lastname: Klimenko
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D001523:Mental Disorders / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism*; D015213:Neuroimmunomodulation / Q000502:physiology; D020734:Parkinsonian Disorders / Q000378:metabolism; D012307:Risk Factors; D012559:Schizophrenia / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha