title: Phenolic enriched extract of Baccharis trimera presents anti-inflammatory and antioxidant activities.
abstract: Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. cristiane_gabi@yahoo.com.br
authors.forename: Cristiane B
authors.initials: CB
authors.lastname: de Oliveira
authors.forename: Lucimara N
authors.initials: LN
authors.lastname: Comunello
authors.forename: Adroaldo
authors.initials: A
authors.lastname: Lunardelli
authors.forename: Robson H
authors.initials: RH
authors.lastname: Amaral
authors.forename: Melissa G S
authors.initials: MG
authors.lastname: Pires
authors.forename: Gabriela Lucas
authors.initials: GL
authors.lastname: da Silva
authors.forename: Vanusa
authors.initials: V
authors.lastname: Manfredini
authors.forename: Carmen Regla
authors.initials: CR
authors.lastname: Vargas
authors.forename: Simone C B
authors.initials: SC
authors.lastname: Gnoatto
authors.forename: Jarbas R
authors.initials: JR
authors.lastname: de Oliveira
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D031175:Baccharis / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000378:metabolism; D002351:Carrageenan; D005260:Female; D020128:Inhibitory Concentration 50; D009569:Nitric Oxide / Q000378:metabolism; D010636:Phenols / Q000737:chemistry*; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010998:Pleurisy / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D009569:Nitric Oxide; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid