title: The results of radiological screening in asymptomatic at-risk members of intracranial aneurysm families from the Turkish population.
abstract: OBJECTIVE
  To better understand the characteristics of familial intracranial aneurysms     (FIA) and to investigate the yield of screening in asymptomatic, at-risk     individuals in intracranial aneurysm (IA) families within the Turkish     population.
  
  
  METHODS
  We identified six families in which at least     two first-degree relative members had an IA in our database. In five families,     we screened 95 first-degree relatives of affected members.
  
  
  RESULTS
  As a result     of our screening, we identified 9 unruptured aneurysms in 95 individuals for a     total yield of 9.4%. There was a prominent female preponderance in affected     family members and nearly half of the aneurysms were on the middle cerebral     artery (MCA). Most of the affected relatives were siblings.
  
  
  CONCLUSIONS
  Our     results support a general recommendation to screen first-degree relatives of IA     patients from families with two or more cases of IA. Familial aggregation of     IA's is not only useful in identifying asymptomatic individuals harboring     unruptured aneurysms but also implicates a genetic contribution to the     pathogenesis of this disease in different patient populations.
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Neurosurgery, Konyaaltı, Antalya, Turkey. ethemgoksu@mynet.com
authors.forename: Ethem
authors.initials: E
authors.lastname: Goksu
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akyuz
authors.forename: Recai
authors.initials: R
authors.lastname: Tuncer
mesh_terms: D000328:Adult; D000368:Aged; D016208:Databases, Factual; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000235:genetics; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D010375:Pedigree; D011859:Radiography; D012306:Risk; D012307:Risk Factors; D012727:Sex Characteristics; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000235:genetics; D014421:Turkey; D055815:Young Adult