title: Absence of nucleotide-binding oligomerization domain-containing protein 2 variants in patients with leprosy and tuberculosis.
abstract: Crohn's disease-associated NOD 2 variants (Arg702Trp and 3020insC) were found to be monomorphic (wild), and 7 subjects were heterozygous for Gly908Arg SNP in 263 patients with tuberculosis, 260 patients with leprosy and 270 healthy controls residing in northern Indian states. This is the first report to suggest the minimal role of these variants in susceptibility/resistance to TB and leprosy in this population.
authors.affiliation: Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Agra, India.
authors.forename: V
authors.initials: V
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Gaur
authors.forename: M
authors.initials: M
authors.lastname: Mittal
authors.forename: S K
authors.initials: SK
authors.lastname: Biswas
authors.forename: R
authors.initials: R
authors.lastname: Das
authors.forename: B K
authors.initials: BK
authors.lastname: Girdhar
authors.forename: B
authors.initials: B
authors.lastname: Bajaj
authors.forename: V M
authors.initials: VM
authors.lastname: Katoch
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: K K
authors.initials: KK
authors.lastname: Mohanty
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D007194:India; D007918:Leprosy / Q000235:genetics* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000472:pathogenicity; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics* / Q000382:microbiology; D055815:Young Adult
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein