title: [Study of pathogenesis of Anaprilin toxicological influence in analysis of central hemodynamic indices and myocardial contractility of isolated heart in experiment].
abstract: Anaprilin under one-shot intraperitoneal introduction to dose 1 and 2 milligrams to 100 grams of animal's body weight causes depending on dose of the change system hemodynamic, myocardial contractility and biochemical factors shelters rats. Anaprilin under one-shot introduction to dose 2 miligrams to 100 grams of animal's body weight change myocardial contractility of isolated heart which were force evidented in the conditions of hypercalcium perfusion and reperfusion.
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: B B
authors.initials: BB
authors.lastname: Iatsiniuk
authors.forename: V G
authors.initials: VG
authors.lastname: Sentsov
authors.forename: K M
authors.initials: KM
authors.lastname: Brusin
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010477:Perfusion / Q000379:methods; D011433:Propranolol / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D011433:Propranolol; D002118:Calcium