title: Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1.
abstract: Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia.
authors.forename: M Z K A
authors.initials: MZ
authors.lastname: Aghafar
authors.forename: C
authors.initials: C
authors.lastname: Witt
authors.forename: A
authors.initials: A
authors.lastname: Kamarulzaman
authors.forename: R
authors.initials: R
authors.lastname: Ismail
authors.forename: M M
authors.initials: MM
authors.lastname: Lederman
authors.forename: B
authors.initials: B
authors.lastname: Rodriguez
authors.forename: D
authors.initials: D
authors.lastname: Senitzer
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: P
authors.initials: P
authors.lastname: Price
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People; D044383:Black People; D016022:Case-Control Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000502:physiology; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D044465:White People; D001741:Black or African American
chemical_list: D015703:Antigens, CD; D059951:HLA-G Antigens; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D011971:Receptors, Immunologic; D054340:Receptors, KIR