title: Moisture plasticization for enteric Eudragit® L30D-55-coated pellets prior to compression into tablets.
abstract: Enteric polymers such as cellulose esters (cellulose acetate phthalate, hydroxypropylmethylcellulose acetate succinate) and methacrylic acid-acrylate copolymers (Eudragit® L100-55 and S100) are quite brittle in the dry state and thus not suitable as pellet coatings for compression into tablets. The objective of this study was to investigate the role of humidity treatment for moisture plasticization in order to successfully compress the enterically coated pellets. The mechanical properties of Eudragit® L100-55 improved dramatically, while the properties of the other enteric polymers showed only minor changes after storage at higher humidity. The significant increase in flexibility of the Eudragit® L film was caused by hydration/plasticization; its elongation value changed from approx. 3% in the dry state to approx. 140% at the higher storage humidity. Storage at 84% relative humidity resulted in comparable release profiles of compressed and uncompressed pellets. The glass transition temperature of Eudragit® L films decreased below the compression temperature (room temperature) at storage humidities between 75% and 84%. The glass transition relative humidity leading to a change from the glassy to the rubbery state was determined by dynamic vapor sorption (DVS) to be 76.8%. Moisture resulted in superior plasticization for Eudragit® L than the conventional plasticizer triethyl citrate. The improved compressibility of high humidity treated Eudragit® L-coated pellets was also shown with single pellet compression data as indicated by an increased crushing force and deformation. In conclusion, moisture plasticization was a highly effective tool to enable the successful compression of pellets coated with the brittle enteric polymer Eudragit® L.
authors.affiliation: College of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, Berlin, Germany.
authors.forename: Soravoot
authors.initials: S
authors.lastname: Rujivipat
authors.forename: Roland
authors.initials: R
authors.lastname: Bodmeier
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D002951:Citrates / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry; D006813:Humidity; D008689:Methacrylates / Q000737:chemistry*; D044367:Phase Transition; D010968:Plasticizers / Q000737:chemistry; D011108:Polymers; D013607:Tablets; D013696:Temperature; D044366:Transition Temperature
chemical_list: D000180:Acrylic Resins; D002951:Citrates; C477852:Eudragit L 30 D-55; C446821:Eudragit L100-55; D005079:Excipients; D008689:Methacrylates; D010968:Plasticizers; D011108:Polymers; D013607:Tablets; C023001:ethyl citrate