title: Lack of association of the cyclooxygenase 8473 T>C polymorphism with lung cancer: evidence from 9841 subjects.
abstract: OBJECTIVE
  Epidemiological studies on the association between T8473C polymorphism of cyclooxygenase 2 (COX 2) and lung cancer risk have provided ambiguous data. To derive a more precise estimation of the association, we conducted a meta-analysis.
  
  
  METHODS
  Systemic searches of the PubMed and MEDLINE databases were performed, with the last report up to May 2011. The meta-analysis was conducted with a fixed/random effect model.
  
  
  RESULTS
  A total of 7 studies including 4,373 lung cancer patients and 5,468 controls were covered. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. No obvious associations were found for all genetic models when all studies were pooled into the meta-analysis (for C vs. T: OR = 0.948, 95% CI = 0.709-1.268; for TC vs. TT: OR = 0.970, 95% CI = 0.823-1.143; for CC vs. TT: OR = 1.141, 95% CI = 0.666-1.956; for CC/TC vs. TT: OR = 1.102, 95% CI = 0.818-1.251; for CC vs. TT/TC: OR = 1.090, 95% CI = 0.716-1.660). In the subgroup analyses by ethnicity (Asian and Caucasian) and source of controls (population based and hospital based), also no significant associations were found for all genetic models.
  
  
  CONCLUSIONS
  Taken together, this meta-analysis suggests that the COX 2 T8473C polymorphism is not associated with lung cancer risk.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.forename: Yueyin
authors.initials: Y
authors.lastname: Pan
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human