title: Cytotoxic phloroglucinols from the leaves of Myrtus communis.
abstract: Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolutionmass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and antibacterial activities.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. cottiglf@unica.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
authors.forename: Laura
authors.initials: L
authors.lastname: Casu
authors.forename: Marco
authors.initials: M
authors.lastname: Leonti
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Caboni
authors.forename: Costantino
authors.initials: C
authors.lastname: Floris
authors.forename: Bernardetta
authors.initials: B
authors.lastname: Busonera
authors.forename: Pamela
authors.initials: P
authors.lastname: Farci
authors.forename: Aicha
authors.initials: A
authors.lastname: Ouhtit
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Sanna
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D007558:Italy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D031651:Myrtus / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; C455139:myrtucommulone A; D010696:Phloroglucinol