title: Sensitive detection of acetaminophen based on Fe₃O₄ nanoparticles-coated poly(diallyldimethylammonium chloride)-functionalized graphene nanocomposite film.
abstract: An electrochemical sensor based on Fe(3)O(4) nanoparticles (NPs)-coated poly(diallyldimethylammonium chloride) (PDDA)-functionalized graphene (Fe(3)O(4)-PDDA-G) nanocomposite was fabricated for sensitive detection of acetaminophen. The nanocomposite was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The electrochemical behaviors of acetaminophen on Fe(3)O(4)-PDDA-G composite film modified glassy carbon electrode (GCE) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental results indicated that the incorporation of Fe(3)O(4) NPs with PDDA-G greatly enhanced the electrochemical response of acetaminophen. This fabricated sensor displayed excellent analytical performance for acetaminophen detection over a range from 0.1 to 100 μ mol L(-1) with a detection limit of 3.7×10(-8) mol L(-1) (S/N=3). The redox peaks of acetaminophen, dopamine (DA) and ascorbic acid (AA) can be well separated on the Fe(3)O(4)-PDDA-G/GCE. Moreover, the proposed electrochemical sensor also exhibited good reproducibility and stability, and has been used to detect acetaminophen in tablets with satisfactory results.
authors.affiliation: Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Daban
authors.initials: D
authors.lastname: Lu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Letao
authors.initials: L
authors.lastname: Wang
authors.forename: Shaoxiong
authors.initials: S
authors.lastname: Lin
authors.forename: Chunming
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D000700:Analgesics / Q000737:chemistry*; D058633:Antipyretics / Q000737:chemistry*; D001205:Ascorbic Acid / Q000032:analysis; D004298:Dopamine / Q000032:analysis; D004566:Electrodes; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D060306:Magnetometry; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010084:Oxidation-Reduction; D011095:Polyethylenes / Q000737:chemistry*; D011199:Potentiometry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D015203:Reproducibility of Results; D014961:X-Ray Diffraction
chemical_list: D000700:Analgesics; D058633:Antipyretics; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D000082:Acetaminophen; D006108:Graphite; D001205:Ascorbic Acid; D004298:Dopamine; D052203:Ferrosoferric Oxide