title: P1 (adenosine) purinoceptor assays.
abstract: P1 purinoceptors, or adenosine (ADO) receptors, mediate the biological effects of the endogenous nucleoside, ADO and its analogs. ADO works through four receptor subtypes: A(1), A(2A), A(2B), and A(3). Isolated tissue assays used for the pharmacological characterization of ADO receptors based on functional responses are described in this unit. The guinea pig atrium, pig coronary artery, guinea pig aorta ,and mouse aorta have been used for the characterization of ADO receptor subtypes.
authors.affiliation: Robert C. Byrd Health Science Center, West Virginia University, Morgantown, West Virginia, USA.
authors.forename: S Jamal
authors.initials: SJ
authors.lastname: Mustafa
authors.forename: Habib R
authors.initials: HR
authors.lastname: Ansari
authors.forename: Worku
authors.initials: W
authors.lastname: Abebe
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D001681:Biological Assay / Q000379:methods*; D003331:Coronary Vessels / Q000187:drug effects; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D051379:Mice; D058906:Purinergic P1 Receptor Agonists / Q000494:pharmacology*; D058915:Purinergic P1 Receptor Antagonists / Q000494:pharmacology*; D018047:Receptors, Purinergic P1 / Q000187:drug effects*; D013048:Specimen Handling; D034421:Sus scrofa
chemical_list: D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1