title: Fatal idiopathic pulmonary haemosiderosis in association with pregnancy - medico-legal evaluation.
abstract: Idiopathic pulmonary haemosiderosis is a rare disorder characterised by repeated episodes of intra-alveolar bleeding in association with consecutive anaemia, pulmonary fibrosis, pulmonary hypertension and respiratory failure. Pregnancy may exacerbate the symptoms of idiopathic pulmonary haemosiderosis typically worsening in the third trimester. A 32-year-old female after delivery was admitted to hospital with progressive dyspnoea of about 1-month duration. Sudden circulatory collapse caused fatal complication. During the post-mortem investigation, lung haemorrhage and histologically abundant iron deposition in macrophages and interstitial fibrosis were found. Medico-legal post-mortem evaluation of fatal cases may support the clinico-pathological context of the diagnosis of this entity.
authors.affiliation: Department of Forensic and Insurance Medicine, Semmelweis University, 1091-Budapest, Üllői út 93, Hungary. torok@igaz.sote.hu
authors.forename: Klára
authors.initials: K
authors.lastname: Töro
authors.forename: Irén
authors.initials: I
authors.lastname: Herjavecz
authors.forename: Edit
authors.initials: E
authors.lastname: Vereckei
authors.forename: Margit
authors.initials: M
authors.lastname: Kovács
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D049429:Forensic Pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D006486:Hemosiderosis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007501:Iron / Q000378:metabolism; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis; D008264:Macrophages / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications; D011658:Pulmonary Fibrosis / Q000473:pathology
chemical_list: D007501:Iron