title: Effect of Alternanthera brasiliana (L) Kuntze on healing of dermal burn wound.
abstract: Wound healing activity of methanol extract of Alternanthera brasiliana [5% (w/w) ointment] was evaluated in experimental burn wound model in rats. Healing potential was assessed by the rate of wound contraction, estimation of anti-oxidants like catalase, superoxide dismutase, reduced glutathione, protein, vitamin C and hydroxyproline, along with histopathological examination on 8th day post wounding. The statistical data indicated that there was significant increase in wound contraction along with augmented level of antioxidants in granulation tissues in A. brasiliana treated group. Histopathological assessment of the granulation tissue revealed formation of epidermis with keratin layer and deposition of collagen fibers after treatment with the plant extract.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India. chanacin@gmail.com
authors.forename: Chandana C
authors.initials: CC
authors.lastname: Baru
authors.forename: Archana
authors.initials: A
authors.lastname: Talukdar
authors.forename: Shameem A
authors.initials: SA
authors.lastname: Begum
authors.forename: Bhaben
authors.initials: B
authors.lastname: Buragohain
authors.forename: Jayanti Datta
authors.initials: JD
authors.lastname: Roy
authors.forename: Debesh C
authors.initials: DC
authors.lastname: Pathak
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Sarma
authors.forename: Asheesh K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Rumi S
authors.initials: RS
authors.lastname: Bora
mesh_terms: D000279:Administration, Cutaneous; D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D020405:Dermis / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006097:Granulation Tissue / Q000187:drug effects; D008297:Male; D009824:Ointments / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017592:Skin Care; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D009824:Ointments; D010936:Plant Extracts; D002374:Catalase