title: Apical functionalization of chiral heterohelicenes.
abstract: We describe a synthetic protocol to selectively functionalize chiral bridged triarylamines at the apical position using regioselective copper-catalyzed amination reaction. This protocol allows the coupling of diphenylamines with a sterically hindered but electronically activated aryl-Br bond in the presence of a sterically unhindered but electronically unactivated aryl-Br bond. The unactivated aryl-Br bond was utilized further to synthesize a chiral heterohelicene homodimer using Stille coupling.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
authors.forename: Sravan K
authors.initials: SK
authors.lastname: Surampudi
authors.forename: G
authors.initials: G
authors.lastname: Nagarjuna
authors.forename: Daiki
authors.initials: D
authors.lastname: Okamoto
authors.forename: Piyali D
authors.initials: PD
authors.lastname: Chaudhuri
authors.forename: D
authors.initials: D
authors.lastname: Venkataraman