title: [Relationship between migraine-type headache in childhood with cow's milk allergy and egg-white allergy].
abstract: OBJECTIVE
  Migraine is a very common headache disorder. Due to the co-occurrence of migraine and allergic disorders, allergic mechanisms have been thought to play a role in migraine pathophysiology. This study aimed to investigate the association between cow's milk allergy and egg-white allergy and migraine-type headache of childhood.
  
  
  METHODS
  We included 39 children with migraine-type headache and 167 children with no headache who had been evaluated previously in a school screening study program. Egg-white and cow's milk-specific IgE levels were measured for all involved subjects.
  
  
  RESULTS
  Specific IgE levels were positive for cow's milk in 4 children and for egg-white in 2 children, respectively. No meaningful relationship was detected between food allergies and migraine. However, specific IgE levels for egg-white were significantly higher in migraineurs (p=0.008).
  
  
  CONCLUSIONS
  Childhood migraine does not appear to be associated with cow's milk or egg-white allergy. However, the elevation of egg-white-specific IgE levels in migraine-type headache may signify the possible presence of shared pathogenetic pathways in the development of migraine and food allergies.
authors.affiliation: Department of Pediatric Allergy, Yeditepe University, İstanbul, Turkey.
authors.forename: Ahmet Oğuzhan
authors.initials: AO
authors.lastname: Ozen
authors.forename: Hülya
authors.initials: H
authors.lastname: Ercan Sarıçoban
authors.forename: Nilgün
authors.initials: N
authors.lastname: Mutlu
authors.forename: Mehmet Reha
authors.initials: MR
authors.lastname: Cengizlier
mesh_terms: D000818:Animals; D002648:Child; D021181:Egg Hypersensitivity / Q000150:complications / Q000276:immunology*; D004529:Egg White; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008881:Migraine Disorders / Q000209:etiology*; D008892:Milk / Q000276:immunology; D016269:Milk Hypersensitivity / Q000150:complications / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E