title: The C-terminal region of E1A: a molecular tool for cellular cartography.
abstract: The adenovirus E1A proteins function via protein-protein interactions. By making many connections with the cellular protein network, individual modules of this virally encoded hub reprogram numerous aspects of cell function and behavior. Although many of these interactions have been thoroughly studied, those mediated by the C-terminal region of E1A are less well understood. This review focuses on how this region of E1A affects cell cycle progression, apoptosis, senescence, transformation, and conversion of cells to an epithelial state through interactions with CTBP1/2, DYRK1A/B, FOXK1/2, and importin-α. Furthermore, novel potential pathways that the C-terminus of E1A influences through these connections with the cellular interaction network are discussed.
authors.affiliation: Department of Microbiology, The University of Western Ontario, London Regional Cancer Program, London, ON N6A 4L6, Canada.
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: Yousef
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Fonseca
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cohen
authors.forename: Joe S
authors.initials: JS
authors.lastname: Mymryk
mesh_terms: D000256:Adenoviridae / Q000502:physiology; D017500:Adenovirus E1A Proteins / Q000737:chemistry / Q000378:metabolism*; D017501:Adenovirus E1B Proteins / Q000378:metabolism; D000818:Animals; D002468:Cell Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D054884:Host-Pathogen Interactions; D006801:Humans; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping
chemical_list: D017500:Adenovirus E1A Proteins; D017501:Adenovirus E1B Proteins