title: Myocardial edema: a translational view.
abstract: Myocardial edema occurs in a large number of myocardial pathologies particularly during ischemia-reperfusion, and may contribute to cell dysfunction and death occurring in these conditions. Cardiomyocyte cell volume is tightly regulated by modifications in cytosolic osmolality. Changes in membrane water permeability through aquaporin and connexin hemichannels also contribute to cell volume changes while caveolae may be important in sensing cell volume changes sensing and associated signaling. Ischemia-reperfusion alters these mechanisms and increases microvascular permeability by endothelial hypercontracture-induced gap formation, endothelial cell death and basal membrane disruption. Detection of myocardial edema by MRI has many useful diagnostic applications in acute myocardial infarction and other conditions. However, discrimination between intra and extracellular myocardial edema is presently difficult at the bench and impossible at the bedside. Developing methods to differentiate intra from extracellular myocardial water should allow a better understanding of the mechanisms and consequences of myocardial edema and, as a consequence lead to new diagnostic and therapeutic applications.
authors.affiliation: Laboratory of Experimental Cardiology, Research Institute Cardiology Department Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron 119-129, 08035 Barcelona, Spain. dgdorado@vhebron.net
authors.forename: David
authors.initials: D
authors.lastname: Garcia-Dorado
authors.forename: Mireia
authors.initials: M
authors.lastname: Andres-Villarreal
authors.forename: Marisol
authors.initials: M
authors.lastname: Ruiz-Meana
authors.forename: Javier
authors.initials: J
authors.lastname: Inserte
authors.forename: Ignasi
authors.initials: I
authors.lastname: Barba
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism / Q000502:physiology; D049108:Cell Enlargement; D048429:Cell Size; D004489:Edema, Cardiac / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology; D009997:Osmotic Pressure; D057170:Translational Research, Biomedical
chemical_list: D020346:Aquaporins