title: [High-grade intraepithelial cervical lesions: evaluation of the factors determining an unfavorable outcome after conization].
abstract: OBJECTIVE
  To evaluate the ability of various factors related to the conization process in cytological/histological cervical intraepithelial neoplasias (CIN), after therapeutic conization.
  
  
  METHODS
  A retrospective review was conducted of patients who had undergone conization due to CIN 2 and 3, from January 1999 to January 2006. They were divided into two groups: case group (residual disease or recurrence) and control group (without residual disease or recurrence), during 18 months of follow up. Univariate and multivariate analysis were used to define the predictive factors of disease recurrence. The χ(2) test or Fisher exact test was used for statistical analysis, with the level of significance set at p≤0.05.
  
  
  RESULTS
  Forty-eight patients showed recurrence/progression of CIN (case group) and 65 showed no recurrence/progression of disease (control group). Age and parity were similar in the two groups, as determined by calculation of the mean and standard deviation. There was no difference in smoking habits or in the use of contraceptive methods. The recurrence rate was 14.6%. Only conization positive margins were predictors of recurrence/progression (p<0.001). The conization techinique, the surgeon, CIN grade, gland involvement, and size of the uterine volume removed were not related to the evolution of disease after surgery.
  
  
  CONCLUSIONS
  The recurrence of CIN 2 and 3 was related to positive margins in the product of conization.
authors.affiliation: Mestranda pela Pontífica Universidade Católica do Paraná; Médica Ginecologista-Obstetra e Genitoscopista do Serviço de Patologia Cervical do Hospital Erasto Gaertner – HEG – Curitiba (PR), Brasil.
authors.forename: Fernanda Villar
authors.initials: FV
authors.lastname: Fonseca
authors.forename: Flávio Daniel Saavedra
authors.initials: FD
authors.lastname: Tomasich
authors.forename: Juliana Elizabeth
authors.initials: JE
authors.lastname: Jung
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery*; D019092:Conization; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery*