title: Relationship between serum undercarboxylated osteocalcin and hyaluronan             levels in patients with bilateral knee osteoarthritis.
abstract: Serum undercarboxylated osteocalcin (s-ucOC) is a marker for vitamin K metabolism             (deficiency). The aim of this study was to investigate the serum levels of ucOC             in patients with bilateral knee osteoarthritis (K-OA), and the correlation between             ucOC and other biomarkers for K-OA. A total of 25 patients (22 women, 3 men, mean             age 76.0±7.8, range 54-88 years, mean BMI 24.9±4.7) with a Kellgren-Lawrence grade             of 3 or 4 for bilateral knee were enrolled in this study. The levels of s-ucOC             and other biomarkers were measured. The levels of s-ucOC (5.66±4.70 ng/ml) as             well as other cartilage metabolism markers, were elevated in the patients; however,             bone metabolism markers were within the normal ranges. Of interest, there was             a significant correlation between s-ucOC and serum hyaluronan (a marker for synovitis)             (P<0.05). Our findings suggest that vitamin K metabolism may be associated             with synovitis in patients with K-OA, and s-ucOC could be a biomarker for K-OA.
authors.affiliation: Department of Orthopaedic Surgery, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka 410-2295, Japan. knaito@juntendo.ac.jp
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Naito
authors.forename: Taiji
authors.initials: T
authors.lastname: Watari
authors.forename: Osamu
authors.initials: O
authors.lastname: Obayashi
authors.forename: Sadanobu
authors.initials: S
authors.lastname: Katsube
authors.forename: Isao
authors.initials: I
authors.lastname: Nagaoka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002356:Cartilage / Q000378:metabolism; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood* / Q000378:metabolism; D007719:Knee Joint / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood* / Q000378:metabolism; D014812:Vitamin K / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D014812:Vitamin K; D006820:Hyaluronic Acid