title: 8-Hydroxydeoxyguanosine: not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases.
abstract: Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG), which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is generally regarded as a biomarker of mutagenesis consequent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-κB signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1, IL-6, cyclo-oxygenase-2, and inducible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1, NOX organizer-1 and NOX activator-1 in various conditions of inflammation-based gastrointestinal (GI) diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carcinogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the prevention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.
authors.affiliation: Lab of Translational Medicine, Gachon University of Medicine and Science, Lee Gil Ya Cancer and Diabetes Institute, 7-45 Songdo-dong, Yeonsu-gu, 406-840 Incheon, South Korea.
authors.forename: Chan-Young
authors.initials: CY
authors.lastname: Ock
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Duck Joo
authors.initials: DJ
authors.lastname: Choi
authors.forename: Ho Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ki-Baik
authors.initials: KB
authors.lastname: Hahm
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Chung
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism*; D003092:Colitis / Q000188:drug therapy; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D015415:Biomarkers; D017382:Reactive Oxygen Species; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine