title: Methods of inducing inflammatory bowel disease in mice.
abstract: Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of disease, identifying new targets for therapeutic intervention, and testing novel therapeutic agents. This unit provides detailed protocols for four of the most commonly used mouse models of experimentally induced intestinal inflammation: chemical induction of colitis by dextran sodium sulfate (DSS), hapten-induced colitis via 2,4,6-trinitrobenzene sulfonic acid (TNBS), Helicobacter-induced colitis in mdr1a(-/-) mice, and the CD4(+) CD45RB(hi) SCID transfer colitis model.
authors.affiliation: Amgen, Seattle, Washington, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Maxwell
authors.forename: William A
authors.initials: WA
authors.lastname: Brown
authors.forename: Carole L
authors.initials: CL
authors.lastname: Smith
authors.forename: Fergus R
authors.initials: FR
authors.lastname: Byrne
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Viney
mesh_terms: D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000637:transplantation; D003092:Colitis / Q000188:drug therapy / Q000209:etiology*; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D016481:Helicobacter Infections; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D013048:Specimen Handling / Q000379:methods; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
chemical_list: D014302:Trinitrobenzenesulfonic Acid; D016264:Dextran Sulfate