title: P53-induced protein with a death domain (PIDD): master of puppets?
abstract: P53-induced protein with a death domain (PIDD) has been described as primary p53 target gene, induced upon DNA damage. More than 10 years after its discovery, its physiological role in the DNA damage response remains enigmatic, as it seems to be able to execute life-death decisions in vitro, yet genetic ablation in mice failed to reveal an obvious phenotype. Nonetheless, evidence is accumulating that it contributes to the fine-tuning of the DNA-damage response by orchestrating critical processes such as caspase activation or nuclear factor κB translocation and can also exert additional nuclear functions, for example, the modulation of translesion synthesis. In this review, we aim to integrate these observations and propose possible unexplored functions of PIDD.
authors.affiliation: Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: F J
authors.initials: FJ
authors.lastname: Bock
authors.forename: L
authors.initials: L
authors.lastname: Peintner
authors.forename: M
authors.initials: M
authors.lastname: Tanzer
authors.forename: C
authors.initials: C
authors.lastname: Manzl
authors.forename: A
authors.initials: A
authors.lastname: Villunger
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D017209:Apoptosis; D053143:Caspase 2 / Q000378:metabolism; D002470:Cell Survival; D004260:DNA Repair; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004789:Enzyme Activation; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D020033:Protein Isoforms / Q000235:genetics; D059748:Proteolysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D053418:Death Domain Receptor Signaling Adaptor Proteins; D016328:NF-kappa B; D020033:Protein Isoforms; D016159:Tumor Suppressor Protein p53; D053143:Caspase 2