title: Rehabilitation for oncogene addiction: role of immunity in cellular sobriety.
abstract: Clinical responses to oncogene inhibitors result from direct effects on cell-intrinsic growth signals and disruption of downstream messages that produce a protumor immunosuppressive microenvironment. Combining oncogene-targeted and immunomodulatory therapies may result in synergistic effects, producing increased response rates and longer periods of tumor control than can be achieved with either class alone.
authors.affiliation: Abramson Family Cancer Research Institute, Hematology-Oncology Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Bajor
authors.forename: Robert H
authors.initials: RH
authors.lastname: Vonderheide
mesh_terms: D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects*; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000473:pathology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors*; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D047428:Protein Kinase Inhibitors; D048493:Proto-Oncogene Proteins B-raf