title: Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
authors.affiliation: Center for Biophysics & Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: Fu-Yang
authors.initials: FY
authors.lastname: Lin
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mary
authors.initials: M
authors.lastname: Hensler
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Liu
authors.forename: Ohn A
authors.initials: OA
authors.lastname: Chow
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Ran
authors.initials: R
authors.lastname: Pang
authors.forename: Wdee
authors.initials: W
authors.lastname: Thienphrapa
authors.forename: Victor
authors.initials: V
authors.lastname: Nizet
authors.forename: Eric
authors.initials: E
authors.lastname: Oldfield
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity; D024341:Xanthophylls / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D024341:Xanthophylls; C031841:staphyloxanthin; C091056:CrtM protein, Staphylococcus aureus; D013186:Farnesyl-Diphosphate Farnesyltransferase