title: Streptozotocin-induced diabetic models in mice and rats.
abstract: Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey, USA.
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Wu
authors.forename: Youming
authors.initials: Y
authors.lastname: Huan
mesh_terms: D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000633:toxicity*; D007328:Insulin / Q000172:deficiency; D050417:Insulin-Secreting Cells / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D013311:Streptozocin