title: Chiral Brønsted acid catalyzed enantioselective propargylation of aldehydes with allenylboronate.
abstract: A highly enantioselective chiral Brønsted acid catalyzed propargylation of aldehydes with allenylboronate is described. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, polyaryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.
authors.affiliation: Chemical and Analytical Development, Novartis Pharmaceutical Corporation, East Hanover, New Jersey 07936, USA. rajender.leleti@novartis.com
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
mesh_terms: D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000143:Acids; D000447:Aldehydes; D001897:Boronic Acids