title: [Post-varicella cerebral thrombophlebitis with anti-protein S: report of a pediatric case].
abstract: Purpura fulminans and venous thrombosis are rare complications of chickenpox. We report the case of a 6 year old with no history individuals who experienced cerebral thrombophlebitis, 3 weeks after varicella. MRI, performed at admission, has objectified longitudinal sinus thrombosis and a frontal parenchymal hematoma law. Meanwhile, a recent varicella seroconversion was demonstrated. The assessment of thrombophilia, meanwhile, has objectified a significant decrease in free protein S and activity, without associated DIC. Origin acquired this deficit was confirmed by the detection of antibodies (IgG and IgM) against the total protein S by ELISA. After evaluation of the benefit/risk only anticoagulation was initiated. The clinical and biological evolution was favorable, with rapid normalization of the S protein and decrease of anti-protein S. Many studies report the presence of anti-protein S in young children at the waning of chickenpox, without their exact frequency is determined. The decrease in protein S they cause leads to a transient hypercoagulable state may result in different clinical pictures. Cases of purpura fulminans seem more frequent when venous thrombosis isolated post chickenpox, sometimes atypical, appear rare.
authors.affiliation: Pôle de pédiatrie, Hôpital de Hautepierre, Strasbourg.
authors.forename: Brice
authors.initials: B
authors.lastname: Samyn
authors.forename: Lélia
authors.initials: L
authors.lastname: Grunebaum
authors.forename: Jean
authors.initials: J
authors.lastname: Amiral
authors.forename: Clément
authors.initials: C
authors.lastname: Ammouche
authors.forename: Karim
authors.initials: K
authors.lastname: Lounis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Eicher
authors.forename: Laurent
authors.initials: L
authors.lastname: Mauvieux
authors.forename: Dominique
authors.initials: D
authors.lastname: Desprez
mesh_terms: D000906:Antibodies / Q000097:blood; D002644:Chickenpox / Q000097:blood / Q000150:complications* / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000150:complications; D017293:Protein S / Q000276:immunology*; D018455:Protein S Deficiency / Q000097:blood / Q000150:complications / Q000276:immunology; D013924:Thrombophlebitis / Q000097:blood / Q000150:complications*; D020293:Vasculitis, Central Nervous System / Q000097:blood / Q000150:complications
chemical_list: D000906:Antibodies; D017293:Protein S