title: No adverse effects of statins on muscle function and health-related parameters in the elderly: an exercise study.
abstract: The aim of the present study was to investigate the effects of a repeated bout of eccentric exercise on health-related parameters and muscle performance on subjects undergoing atorvastatin therapy. Twenty-eight elderly men participated in the investigation and were assigned either in a control (n = 14) or in a statin therapy group (n = 14). All participants performed two isokinetic eccentric exercise bouts separated by 3 weeks. Muscle damage indices, resting energy expenditure, substrate metabolism, lipid and lipoprotein profile, as well as insulin sensitivity, were evaluated before and after eccentric. No differences in muscle function were observed between the two groups either at rest or after exercise. Eccentric exercise increased resting energy expenditure, increased fat oxidation, improved lipid profile, and increased insulin resistance 2 days after both eccentric exercise bouts. However, these changes appeared to lesser extent after the second bout. No differences were observed in the responses in the health-related parameters in the control and in the statin therapy group. Eccentric exercise affected similarly the control and the atorvastatin-treated individuals. The present results indicate that atorvastatin-treated elderly individuals may participate in various physical activities, even high-intensity muscle-damaging activities, without negative impact on muscle function and adaptation.
authors.affiliation: Institute of Human Performance and Rehabilitation, Center for Research and Technology - Thessaly, Trikala, Greece; Laboratory of Exercise, Health and Human Performance, Research Center, European University of Cyprus, Nicosia, Cyprus.
authors.forename: G
authors.initials: G
authors.lastname: Panayiotou
authors.forename: V
authors.initials: V
authors.lastname: Paschalis
authors.forename: M G
authors.initials: MG
authors.lastname: Nikolaidis
authors.forename: A A
authors.initials: AA
authors.lastname: Theodorou
authors.forename: C K
authors.initials: CK
authors.lastname: Deli
authors.forename: N
authors.initials: N
authors.lastname: Fotopoulou
authors.forename: I G
authors.initials: IG
authors.lastname: Fatouros
authors.forename: Y
authors.initials: Y
authors.lastname: Koutedakis
authors.forename: M
authors.initials: M
authors.lastname: Sampanis
authors.forename: A Z
authors.initials: AZ
authors.lastname: Jamurtas
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D000069059:Atorvastatin; D001824:Body Constitution; D015992:Body Mass Index; D016022:Case-Control Studies; D015930:Diet Records; D004734:Energy Metabolism / Q000187:drug effects*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin