title: Cardiovascular magnetic resonance findings in a pediatric population with isolated left ventricular non-compaction.
abstract: BACKGROUND
  Isolated left ventricular non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that ejection fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics of LVNC and ventricular function. We aimed to find correlations between morphological features and ventricular performance in children and young adolescents with LVNC using cardiovascular magnetic resonance (CMR).
  
  
  METHODS
  15 children with LVNC (10 males, mean age 9.7 y.o., range 0.6-17 y.o.), underwent a CMR scan. Different morphological measures such as the compacted myocardial mass (CMM), non-compaction (NC) to the compaction (C) distance ratio, compacted myocardial area (CMA) and non-compacted myocardial area (NCMA), distribution of NC, and the assessment of ventricular wall motion abnormalities were performed to investigate correlations with ventricular performance. EF was considered normal over 53%.
  
  
  RESULTS
  The distribution of non-compaction in children was similar to published adult data with a predilection for apical, mid-inferior and mid-lateral segments. Five patients had systolic dysfunction with decreased EF. The number of affected segments was the strongest predictor of systolic dysfunction, all five patients had greater than 9 affected segments. Basal segments were less commonly affected but they were affected only in these five severe cases.
  
  
  CONCLUSIONS
  The segmental pattern of involvement of non-compaction in children is similar to that seen in adults. Systolic dysfunction in children is closely related to the number of affected segments.
authors.affiliation: Radiology Department, Pontificia Universidad Católica de Chile, Marcoleta 367, Hospital Clinico Universidad Catolica, Santiago 8330024, Santiago Chile. suribe@med.puc.cl
authors.forename: Sergio
authors.initials: S
authors.lastname: Uribe
authors.forename: Lina
authors.initials: L
authors.lastname: Cadavid
authors.forename: Tarique
authors.initials: T
authors.lastname: Hussain
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Parra
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Urcelay
authors.forename: Felipe
authors.initials: F
authors.lastname: Heusser
authors.forename: Marcelo
authors.initials: M
authors.lastname: Andía
authors.forename: Cristian
authors.initials: C
authors.lastname: Tejos
authors.forename: Pablo
authors.initials: P
authors.lastname: Irarrazaval
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002677:Chile; D005260:Female; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D016014:Linear Models; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left