title: Natural products as sources of new fungicides: synthesis and antifungal activity of zopfiellin analogues.
abstract: The synthesis of a series of cyclooctadiene anhydrides, analogues of the natural compound zopfiellin, was performed to assay their in vitro and in vivo antifungal activity on a set of plant pathogenic fungi. Most of the synthesized compounds possessed a broad spectrum of activity. In particular, the anhydrides 2 and 5a were very effective against the Oomycete diseases such as Phytophthora infestans and Pythium ultimum, reaching a level of activity well comparable with that of commercial fungicides in use. Preliminary in vivo evaluation of their protectant activity is also reported.
authors.affiliation: Dipartimento di Scienze Molecolari Agroalimentari, Università degli Studi di Milano, via Celoria 2, Milan, Italy. loana.musso@unimi.it
authors.forename: Loana
authors.initials: L
authors.lastname: Musso
authors.forename: Sabrina
authors.initials: S
authors.lastname: Dallavalle
authors.forename: Gandolfina
authors.initials: G
authors.lastname: Farina
authors.forename: Elio
authors.initials: E
authors.lastname: Burrone
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D034242:Cyclooctanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009868:Oomycetes / Q000187:drug effects*; D055750:Phytophthora infestans / Q000187:drug effects; D010935:Plant Diseases / Q000382:microbiology*; D010944:Plants / Q000382:microbiology*
chemical_list: D001688:Biological Products; D034242:Cyclooctanes; D005659:Fungicides, Industrial; C470145:zopfiellin