title: Novel bivalent vectored vaccine for control of myxomatosis and rabbit haemorrhagic disease.
abstract: A novel, recombinant myxoma virus-rabbit haemorrhagic disease virus (RHDV) vaccine has been developed for the prevention of myxomatosis and rabbit haemorrhagic disease (RHD). A number of laboratory studies are described illustrating the safety and efficacy of the vaccine following subcutaneous administration in laboratory rabbits from four weeks of age onwards. In these studies, both vaccinated and unvaccinated control rabbits were challenged using pathogenic strains of RHD and myxoma viruses, and 100 per cent of the vaccinated rabbits were protected against both myxomatosis and RHD.
authors.affiliation: MSD Animal Health, Milton Keynes, UK. norman.spibey@merck.com
authors.forename: N
authors.initials: N
authors.lastname: Spibey
authors.forename: V J
authors.initials: VJ
authors.lastname: McCabe
authors.forename: N M
authors.initials: NM
authors.lastname: Greenwood
authors.forename: S C
authors.initials: SC
authors.lastname: Jack
authors.forename: D
authors.initials: D
authors.lastname: Sutton
authors.forename: L
authors.initials: L
authors.lastname: van der Waart
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D018562:Disease Transmission, Infectious / Q000517:prevention & control / Q000662:veterinary; D017929:Hemorrhagic Disease Virus, Rabbit / Q000276:immunology*; D009233:Myxoma virus / Q000276:immunology*; D009234:Myxomatosis, Infectious / Q000517:prevention & control*; D011817:Rabbits; D014611:Vaccination / Q000662:veterinary*; D017778:Vaccines, Combined / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D017778:Vaccines, Combined; D014765:Viral Vaccines