title: Correlation between the preoperative serum prostate specific antigen, Gleason score, and clinical staging with pathological outcome following robot-assisted radical prostatectomy: an Indian experience.
abstract: OBJECTIVE
  To correlate the preoperative serum prostate specific antigen (PSA), Gleason score, and clinical staging with pathological outcome following robot-assisted radical prostatectomy (RARP) in Indian men with clinically localized cancer prostate.
  
  
  METHODS
  A prospective study analysis was done for 166 consecutive patients of prostate cancer who underwent RARP at our center from June 2006 to October 2009. Preoperative workup included serum PSA, biopsy Gleason score, and clinical staging. The preoperative parameters were correlated with final Gleason score, capsular penetration, seminal vesicle involvement, and lymph node status on final histopathology.
  
  
  RESULTS
  The mean age was 64 years (range: 50-76 years) with mean and median PSA of 17.98 ng/ml (range: 0.3-68.3 ng/ml) and 12.1 ng/ml, respectively. With increase in preoperative Gleason score, chance of organ confinement decreases (P=0.002) and capsular penetration increases (P=0.004) linearly. With increasing serum PSA, there is linear decrease in trend of organ-confined disease (P=0.03) and increased chances of seminal vesicle involvement (P=0.02). Patients with higher clinical stage have less probability of localized disease (P=0.007) and more chances of capsular penetration (P=0.04) and seminal vesicle involvement (P=0.004).
  
  
  CONCLUSIONS
  Our data suggest that patients with higher preoperative serum PSA, Gleason score, and clinical stage have more chances of advanced pathological stage following RARP.
authors.affiliation: Department of Urology, AIIMS, New Delhi, India. drprabhjotsingh@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: P N
authors.initials: PN
authors.lastname: Dogra
authors.forename: N P
authors.initials: NP
authors.lastname: Gupta
authors.forename: R
authors.initials: R
authors.lastname: Nayyar
authors.forename: A
authors.initials: A
authors.lastname: Seth
authors.forename: T D
authors.initials: TD
authors.lastname: Javali
authors.forename: R
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood; D018450:Disease Progression; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D057234:Preoperative Period; D011379:Prognosis; D011446:Prospective Studies; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D012371:Robotics
chemical_list: D000951:Antigens, Neoplasm