title: [Research progress of tumor cell migration strategy and the migration transition mechanism].
abstract: Tumor cells exhibit two main different migration strategies when invading in 3D environment, i. e. mesenchymal migration and amoeboid migration. This review summarizes the internal reasons and characteristics on various modes of migration adaptation to the microenvironment, and the molecular mechanisms in particular environment where they are mutually interchangeable. A study of the mechanisms that may possibly trigger mesenchymal-amoeboid transition/amoeboid-mesenchymal transition help us to understand the change and the plasticity in the migration strategies of tumor cells. These are important for the development of a cancer treatment, which would efficiently suppress tumor cell invasiveness.
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400044, China. whbdzx@yahoo.com.cn
authors.forename: Hongbing
authors.initials: H
authors.lastname: Wang
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Tan
authors.forename: Ben Yanzi
authors.initials: BY
authors.lastname: Yang
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zou
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D002465:Cell Movement / Q000502:physiology*; D005109:Extracellular Matrix / Q000473:pathology; D006801:Humans; D016023:Integrins / Q000502:physiology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000503:physiopathology*
chemical_list: D016023:Integrins