title: Repeat lumpectomy for ipsilateral breast tumor recurrence after breast-conserving treatment.
abstract: OBJECTIVE
  There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR).
  
  
  METHODS
  We retrospectively analyzed 78 patients who underwent repeat lumpectomy after IBTR. The risk factors for second IBTR were assessed.
  
  
  RESULTS
  The median follow-up period was 40 months. The 5-year second IBTR-free survival rate was 78.8%. Patients with estrogen receptor (ER)-positive or unknown tumors at IBTR had a significantly better second IBTR-free survival rate than those with ER-negative tumors at IBTR (88.3 vs. 55.4%, respectively; p = 0.0022). Multivariate analysis revealed that the ER status of IBTR was a significantly independent predictive factor for second IBTR-free survival (p = 0.0177). The low-risk group for second IBTR was detected using the ER status, disease-free interval, margin status of IBTR, and age at diagnosis (5-year cumulative incidence, 7.0%).
  
  
  CONCLUSIONS
  The ER status of IBTR was a significantly independent predictive factor for second IBTR-free survival. Some patients could safely undergo repeat lumpectomy for IBTR.
authors.affiliation: Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. isitobi-ma@mc.pref.osaka.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishitobi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Komoike
authors.forename: Saki
authors.initials: S
authors.lastname: Nakahara
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Motomura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Koyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Inaji
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000601:surgery*; D011237:Predictive Value of Tests; D011960:Receptors, Estrogen / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D011960:Receptors, Estrogen