title: Gastrointestinal models: intestinal transit, gastric emptying, and ulcerogenic activity in the rat.
abstract: The protocols described in this unit are designed to assess the effects of substances on intestinal transit and gastric emptying and to evaluate their ulcerogenic potential on the stomach and duodenum of the rat. Examples of results obtained with atropine or morphine (intestinal transit), loperamide (gastric emptying), or indomethacin (ulcerogenic activity) used as reference substances are provided for illustrative purposes. Atropine and morphine clearly reduce intestinal transit. Atropine, morphine, and loperamide clearly reduce gastric emptying. Indomethacin shows a marked ulcerogenic potential.
authors.affiliation: Porsolt and Partners Pharmacology, Boulogne-Billancourt, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guillaume
authors.forename: Daniel
authors.initials: D
authors.lastname: Provost
authors.forename: Pierre
authors.initials: P
authors.lastname: Lacroix
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D064420:Drug-Related Side Effects and Adverse Reactions / Q000503:physiopathology / Q000517:prevention & control*; D005746:Gastric Emptying / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*