title: Angiogenin and SDF-1α serum concentration in patients with systemic sclerosis in relation to clinical status.
abstract: BACKGROUND
  Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue hypoxia due to vascular changes and excessive fibrosis of the skin and internal organs. Damage to blood vessels and endothelium, as well as imbalance of vascular homeostasis, impairment of angiogenesis and vasculogenesis are observed in the course of the disease. The aim of the study was to investigate the pro-angiogenic factors angiogenin and SDF-1α in patients with SSc.
  
  
  METHODS
  Serum samples were collected from 50 patients with dSSc (diffuse SSc) and lSSc (limited SSc) and from 38 patients used as a healthy control group. We explored: 1) how the serum concentrations of SDF-1α and angiogenin differ in the investigated groups; 2) the correlation among chemokines in SSc and the duration of the disease, Raynaud's phenomenon, sclerosis of the skin and TSS (total skin score).
  
  
  RESULTS
  Patients with SSc showed statistically significantly higher serum angiogenin concentration and there was no correlation between duration of the disease and Raynaud's phenomenon, skin sclerosis or TSS. There was also no difference or no correlation between serum level of SDF-1α and the investigated groups.
  
  
  CONCLUSIONS
  The increase in angiogenin concentration in the serum in patients with SSc may confirm endothelial damage caused by hypoxia and reduced vascular perfusion due to the course of SSc without contributing to compensatory revascularization.
authors.affiliation: Department of Immunodermatology, Medical University of Lodz, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Dziankowska-Bartkowiak
authors.forename: Zofia
authors.initials: Z
authors.lastname: Gerlicz-Kowalczuk
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Waszczykowska