title: Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats.
abstract: Cigarettes smoke (CS) limits food intake and body weight increase. Ghrelin and leptin are hormones regulating appetite and energy balance. While ghrelin increases food intake and causes a positive energy balance, leptin decreases food intake and enhances a negative energy balance. To investigate the possible role of ghrelin and leptin regarding the negative energy balance caused by CS, 10-week old male Wistar rats (n = 10) were exposed to CS from 30 cigarettes twice a day for 5 days a week for four weeks. In the smoking group, food intake and body weight gain were less than those in the non-smoking group (n = 10) during the entire CS exposure. In the smoking group, the plasma levels of acyl ghrelin were significantly higher (75.9 ± 5.1 fmol/ml versus 46.5 ± 3.3 fmol/ml, p < 0.01), while those of leptin were significantly lower than those in the non-smoking group (434.9 ± 41.1 ng/ml versus 744.0 ± 45.4 ng/ml, p < 0.01) after the final CS exposure. However, the plasma des-acyl ghrelin levels were not affected by CS exposure. These results suggested that acyl ghrelin and leptin levels in plasma may change to compensate for the negative energy balance by CS.
authors.affiliation: Second Department of Internal Medicine, Nara Medical University, 840 Shijocho, Kashihara City, Nara 634-8522, Japan. ktomoda@naramed-u.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Tomoda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kubo
authors.forename: Yasue
authors.initials: Y
authors.lastname: Nishii
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000818:Animals; D002263:Carboxyhemoglobin / Q000032:analysis; D004435:Eating / Q000187:drug effects; D054439:Ghrelin / Q000097:blood*; D006861:Hydrogen Peroxide / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012907:Smoking / Q000009:adverse effects*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D054439:Ghrelin; D020738:Leptin; D002263:Carboxyhemoglobin; D006861:Hydrogen Peroxide