title: Short-term versus long-term administration of single prophylactic antibiotic in elective gastric tumor surgery.
abstract: OBJECTIVE
  To evaluate short-term versus long-term single prophylactic antibiotic for elective gastric tumor surgery.
  
  
  METHODS
  Patients in a single surgical team undergoing elective gastric tumor surgery were enrolled from November 2009 to December 2010. The included patients were aged from 18 to 70 years without conditions as severe comorbidity, preoperative infectious diseases, antibiotic administration 48 h before surgery, exploratory laparotomy only or combined colorectal resection, neoadjuvant chemotherapy, or steroid administration before surgery. The overall and infection-related postoperative complications and also economic outcomes were analyzed. The software SPSS 17.0 and TreeAge Pro 2007 were used for statistics.
  
  
  RESULTS
  Patients (n=158 (45 vs. 113)) were enrolled in short-term and long-term groups. No death cases occurred. Overall postoperative complication rates were 8.9% and 8.0%, respectively (p=1.000). The rates of infection related complications were 8.9% and 4.4%, respectively (p=0.231). No surgical site infection (SSI) occurred in the short-term group, whereas SSI was 1.8% in the long-term group. Total hospitalization cost (THC) of short-term branch was 36,557RMB per patients and preferable against 39,523RMB of long-term branch. Incremental cost-effectiveness analysis showed there was a 10 times interval between the extra healthcare expenditure of benefit and harm.
  
  
  CONCLUSIONS
  Short-term administration did not increase the risk of postoperative complications and was more cost-effective.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Xin-Zu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Chen
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Chen
authors.forename: Jian-Kun
authors.initials: JK
authors.lastname: Hu
authors.forename: Zong-Guang
authors.initials: ZG
authors.lastname: Zhou
authors.forename: Xian-Min
authors.initials: XM
authors.lastname: Mo
authors.forename: Xian-Min
authors.initials: XM
authors.lastname: Mo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000191:economics; D019072:Antibiotic Prophylaxis / Q000191:economics; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D016009:Chi-Square Distribution; D002681:China; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D016527:Drug Costs; D017558:Elective Surgical Procedures; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000191:economics; D015390:Gastric Bypass / Q000009:adverse effects / Q000191:economics; D017721:Hospital Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000191:economics / Q000601:surgery*; D013530:Surgical Wound Infection / Q000191:economics / Q000382:microbiology / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents