title: Rutin-phospholipid complex: an innovative technique in novel drug delivery system- NDDS.
abstract: Biopharmaceutical properties together with potency contribute critically towards clinical efficacy of the drugs by influencing the dissolution and bioavailability. The aim of this study was to develop an amphiphilic phyto-phospholipid complex in order to enhance the delivery of poorly soluble rutin. The rutin-phospholipid complex (Ru-PLc) was prepared and investigated for various physico-chemical parameters like drug loading, infrared absorption (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), scanning electron microscopy (SEM), aqueous/ n-octanol solubility and dissolution study. The in vitro anti-oxidant activity was also studied. In the SEM, Ru-PLc was found fluffy and porous with rough surface morphology. FTIR, DSC and XRPD data confirmed the formation of phospholipid complex. The water/ noctanol solubility of rutin was improved from 2.88 to 45.71 μg/ ml and 68.17 to 245.18 μg/ ml, respectively in the complex. The improved dissolution was shown by the phospholipid complex at different pH buffers. The antioxidant activity indicated that, the bioactivity of rutin was maintained even after being complexed with the phospholipid. Based on the results, it can be concluded that the phospholipid complex may be considered as a promising drug delivery system for improving the overall absorption and bioavailability of the rutin molecule.
authors.affiliation: Department of Chemistry, H. N. B. Garhwal University, Srinagar (Garhwal), Uttarakhand, India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Singh
authors.forename: M S M
authors.initials: MS
authors.lastname: Rawat
authors.forename: Ajay
authors.initials: A
authors.lastname: Semalty
authors.forename: Mona
authors.initials: M
authors.lastname: Semalty
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000737:chemistry*; D010851:Picrates / Q000037:antagonists & inhibitors; D033362:Powder Diffraction; D012431:Rutin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010713:Phosphatidylcholines; D010851:Picrates; D012431:Rutin; C004931:1,1-diphenyl-2-picrylhydrazyl