title: Selective breeding for endurance running capacity affects cognitive but not motor learning in rats.
abstract: The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication of aerobic capacity, also has an effect on learning. Rats selectively bred over 23 generations for their ability to perform forced treadmill running were trained in an appetitively motivated discrimination-reversal classical conditioning task, an alternating T-maze task followed by a rule change (from a shift-win to stay-win rule) and motor learning task. In the discrimination-reversal and T-maze tasks, the high-capacity runner (HCR) rats outperformed the low-capacity runner (LCR) rats, most notably in the phases requiring flexible cognition. In the Rotarod (motor-learning) task, the HCR animals were overall more agile but learned at a similar rate with the LCR group as a function of training. We conclude that the intrinsic ability to utilize oxygen is associated especially with tasks requiring plasticity of the brain structures implicated in flexible cognition.
authors.affiliation: Department of Psychology, University of Jyväskylä, Finland. jan.wikgren@jyu.fi
authors.forename: Jan
authors.initials: J
authors.lastname: Wikgren
authors.forename: Georgios G
authors.initials: GG
authors.lastname: Mertikas
authors.forename: Pekka
authors.initials: P
authors.lastname: Raussi
authors.forename: Riina
authors.initials: R
authors.lastname: Tirkkonen
authors.forename: Laura
authors.initials: L
authors.lastname: Äyräväinen
authors.forename: Markku
authors.initials: M
authors.lastname: Pelto-Huikko
authors.forename: Lauren G
authors.initials: LG
authors.lastname: Koch
authors.forename: Steven L
authors.initials: SL
authors.lastname: Britton
authors.forename: Heikki
authors.initials: H
authors.lastname: Kainulainen
mesh_terms: D000818:Animals; D001947:Breeding; D003214:Conditioning, Classical; D004193:Discrimination Learning; D005260:Female; D018782:Maze Learning; D010805:Physical Conditioning, Animal / Q000523:psychology*; D010807:Physical Endurance; D051381:Rats; D011919:Rats, Inbred Strains; D045442:Rotarod Performance Test; D012420:Running / Q000523:psychology*