title: Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes.
abstract: High-volume endurance exercise (END) improves glycaemic control in type 2 diabetes (T2D) but many individuals cite 'lack of time' as a barrier to regular participation. High-intensity interval training (HIT) is a time-efficient method to induce physiological adaptations similar to END, but little is known regarding the effect of HIT in T2D. Using continuous glucose monitoring (CGM), we examined the 24-h blood glucose response to one session of HIT consisting of 10 × 60 s cycling efforts at ~90% maximal heart rate, interspersed with 60 s rest. Seven adults with T2D underwent CGM for 24-h on two occasions under standard dietary conditions: following acute HIT and on a non-exercise control day (CTL). HIT reduced hyperglycaemia measured as proportion of time spent above 10 mmol/l (HIT: 4.5 ± 4.4 vs. CTL: 15.2 ± 12.3%, p = 0.04). Postprandial hyperglycaemia, measured as the sum of post-meal areas under the glucose curve, was also lower after HIT vs. CTL (728 ± 331 vs. 1142 ± 556 mmol/l·9 h, p = 0.01). These findings highlight the potential for HIT to improve glycaemic control in T2D.
authors.forename: J B
authors.initials: JB
authors.lastname: Gillen
authors.forename: J P
authors.initials: JP
authors.lastname: Little
authors.forename: Z
authors.initials: Z
authors.lastname: Punthakee
authors.forename: M A
authors.initials: MA
authors.lastname: Tarnopolsky
authors.forename: M C
authors.initials: MC
authors.lastname: Riddell
authors.forename: M J
authors.initials: MJ
authors.lastname: Gibala
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015190:Blood Glucose Self-Monitoring; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000628:therapy; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015995:Prevalence; D013997:Time Factors
chemical_list: D001786:Blood Glucose