title: [Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior].
abstract: OBJECTIVE
  To investigate the genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) technique was used to detect the genotype of ADH3 and ALDH2. Drinking behavior was obtained by questionnaire.
  
  
  RESULTS
  The frequency of ADH3*2 and ALDH2*2 alleles in Tibetan population was 7.79% and 22.21% respectively, the frequency of ALDH2*2 and ADH3*1 alleles in non-drinkers was higher than that in drinkers, and the frequency of ALDH2*2 and ADH3*1 alleles in risk drinkers was lower than that in safe drinkers.
  
  
  CONCLUSIONS
  ADH3 and ALDH2 are associated with drinking behavior in male Tibetan population.
authors.affiliation: Department of Toxicology, College of Public Health, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Xingxiang
authors.initials: X
authors.lastname: Li
authors.forename: Chaocai
authors.initials: C
authors.lastname: Wang
authors.forename: Benzhong
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D002681:China / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018609:Tibet; D055815:Young Adult
chemical_list: C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial