title: [Proton magnetic resonance spectroscopy as a time clock measurement device in cerebral ischemia].
abstract: Proton magnetic resonance spectroscopy ((1)H-MRS) non-invasively provides in vivo biochemical information on tissue metabolites. In acute stage of cerebral ischemia, N-acetyl aspartate (NAA), one of (1)H-MRS observable metabolite, declines gradually reflecting energy impairment due to oxygen depletion. In our study, decline of NAA in ischemic core linearly correlated with the time from the onset of ischemia. Therefore NAA can be utilized to time clock biomarker for the acute stage cerebral ischemia.
authors.affiliation: Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata.
authors.forename: Hironaka
authors.initials: H
authors.lastname: Igarashi
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001224:Aspartic Acid; C000179:N-acetylaspartate