title: Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.
abstract: Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.
authors.affiliation: Pulmonary Disease Program, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Aggarwal
authors.forename: Christine
authors.initials: C
authors.lastname: Gross
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Fineman
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Black
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011652:Pulmonary Circulation / Q000502:physiology; D012756:Sheep; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D019001:Nitric Oxide Synthase