title: Acute administration of the organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one induces biochemical and hematological disorders in male rats.
abstract: Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on biochemical and hematological parameters in male Wistar rats. The animals were treated with a single intraperitoneal injection of the organochalcogen at doses of 125, 250 or 500 µg·kg(-1). After 60 min, the animals were sacrificed by decapitation, and the trunk blood was collected for determination of glucose, triglycerides, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase, lactate dehydrogenase, urea, creatinine, C-reactive protein, red blood cells, hematocrit, hemoglobin and white blood cells (WBC). Our results showed a reduction in cholesterol levels in all treated groups, an increase in ALT activity at doses of 250 and 500 µg·kg(-1), a decrease of hemoglobin and an increase in WBC in animals that received 250 and 500 µg·kg(-1) of the organoselenium. In addition, we observed an increase in neutrophil counts at 125 µg·kg(-1) dose and a decrease at 500 µg·kg(-1) dose. We also verified an increase in lymphocyte counts at the dose of 500 µg·kg(-1). Thus, the present study shows that the acute treatment with this new organochalcogen causes biochemical changes and hematological disorders in male rats.
authors.affiliation: Centro Universitário Metodista IPA, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: dos Santos Lacerda
authors.forename: Vanessa
authors.initials: V
authors.lastname: de Oliveira Castro
authors.forename: Marcello
authors.initials: M
authors.lastname: Mascarenhas
authors.forename: Robson Brum
authors.initials: RB
authors.lastname: Guerra
authors.forename: Caroline
authors.initials: C
authors.lastname: Dani
authors.forename: Adriana
authors.initials: A
authors.lastname: Coitinho
authors.forename: Rosane
authors.initials: R
authors.lastname: Gomez
authors.forename: Cláudia
authors.initials: C
authors.lastname: Funchal
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002784:Cholesterol / Q000097:blood; D006402:Hematologic Diseases / Q000378:metabolism* / Q000473:pathology; D006454:Hemoglobins / Q000032:analysis; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C568342:3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one; D006454:Hemoglobins; D016566:Organoselenium Compounds; D002784:Cholesterol; D000410:Alanine Transaminase