title: Hemostatic efficacy of folkloric medicinal plant extract in a rat skin bleeding model.
abstract: OBJECTIVE
  To assess the in vivo hemostatic effect of a folkloric medicinal plant extract.
  
  
  METHODS
  Wistar rats were randomized into four groups of seven. Group 1, a control group, received no pretreatment and was irrigated with saline. Group 2 received no pretreatment and was irrigated with the plant extract. Group 3, a control group, received pretreatment with heparin and was irrigated with saline. Group 4 received pretreatment with heparin and was irrigated with the plant extract. A standardized skin-bleeding model was created using full-thickness skin defects on the Wistar rats' dorsal skin. To control bleeding, compressive dressings were placed after inserting 1 mL of the plant extract or saline into the bleeding area. Hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with the plant extract.
  
  
  RESULTS
  Without heparin pretreatment, the folkloric medicinal plant extract shortened the hemostasis time by 1.29 minute and reduced the amount of bleeding by 0.63 g. With heparin pretreatment, the plant extract shortened the hemostasis time by 2.29 minutes and reduced the amount of bleeding by 0.70 g.
  
  
  CONCLUSIONS
  The medicinal plant extract irrigation was more effective than saline irrigation for treating hemorrhagic skin defects in animals using a compressive dressing with or without heparin pretreatment.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Rize University, Rize, Turkey. drosogut@harran.edu.tr
authors.forename: Rustu
authors.initials: R
authors.lastname: Kose
authors.forename: Ozgur
authors.initials: O
authors.lastname: Sogut
authors.forename: Tuncer
authors.initials: T
authors.lastname: Demir
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Koruk
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006470:Hemorrhage / Q000188:drug therapy*; D006490:Hemostatics / Q000494:pharmacology*; D029001:Herbal Medicine; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D018709:Statistics, Nonparametric
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper