title: Intermolecular Ritter-type C-H amination of unactivated sp3 carbons.
abstract: Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Michaudel
authors.forename: Damien
authors.initials: D
authors.lastname: Thevenet
authors.forename: Phil S
authors.initials: PS
authors.lastname: Baran
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D006838:Hydrocarbons / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000577:Amides; D000588:Amines; D006838:Hydrocarbons; D007659:Ketones