title: Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.
abstract: Painful peripheral neuropathy induced by chronic ethanol consumption is a major medico-socioeconomical problem. The objective of present investigation was to study the effect of curcumin (20, 40 and 80mg/kg; p.o.) in alcohol-induced neuropathy in rats. Ethanol (35% v/v, 10g/kg; p.o.) was administered for 10 weeks which showed a significant decrease in thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia and nerve conduction velocity. It caused enhanced malondialdehyde, oxidative-nitrosative stress, total calcium levels, inflammatory mediators (TNF-α and IL-1β levels) along with DNA damage. Co-administration of curcumin and α-tocopherol for 10 weeks significantly and dose-dependently improved nerve functions, biochemical as well as molecular parameters and DNA damage in sciatic nerve of ethanol treated rats. Hence, it was concluded that curcumin is of potent therapeutic value in the amelioration of alcoholic neuropathy in rats and acts by inhibition of pro-inflammatory mediators like TNF-α and IL-1β.
authors.affiliation: Department of Pharmacology, Poona college of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra-411038, India.
authors.forename: Amit D
authors.initials: AD
authors.lastname: Kandhare
authors.forename: Kiran S
authors.initials: KS
authors.lastname: Raygude
authors.forename: Pinaki
authors.initials: P
authors.lastname: Ghosh
authors.forename: Arvindkumar E
authors.initials: AE
authors.lastname: Ghule
authors.forename: Subhash L
authors.initials: SL
authors.lastname: Bodhankar
mesh_terms: D020269:Alcoholic Neuropathy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage / Q000627:therapeutic use*; D053938:DNA Fragmentation / Q000187:drug effects; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D053583:Interleukin-1beta / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D003474:Curcumin; D002118:Calcium