title: Combined study of anion recognition by a carbazole-based neutral tripodal receptor in a competitive environment.
abstract: Anion recognition studies have been carried out on a series of neutral synthetic receptors in which carbazole-2-carboxamide has been used as building block. Different ligands which include one to three carbazole units in their structure have been prepared. Binding experiments have been performed under competitive conditions in DMSO and DMSO-water solutions. The tripodal receptor offered a better host-guest association due to the synergistic effect of a well arranged set of hydrogen bonds. A selective response towards the biologically important pyrophosphate anion has been achieved. This selectivity is enhanced when studies are carried out with an increasing water content, which gets as high as 20% (v/v) in NMR experiments. The significance of this result lies in the use of a neutral receptor which exclusively interacts with the anionic guest through hydrogen bonding. The influence of multiple equilibria in the studied system has been analysed. Several techniques ((1)H NMR, (31)P NMR, mass spectrometry, diffusion-NMR, ITC, absorption and emission spectroscopy) have been employed to get a better understanding of the different processes taking place in solution for the evaluated receptors.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, Campus of Espinardo, 30100-Murcia, Spain. davidcc@um.es
authors.forename: David
authors.initials: D
authors.lastname: Curiel
authors.forename: Guzmán
authors.initials: G
authors.lastname: Sánchez
authors.forename: Carmen
authors.initials: C
authors.lastname: Ramírez de Arellano
authors.forename: Alberto
authors.initials: A
authors.lastname: Tárraga
authors.forename: Pedro
authors.initials: P
authors.lastname: Molina