title: [Pathomechanism and prevalence of sporadic inclusion body myositis (sIBM)].
abstract: Sporadic inclusion body myositis (sIBM) is an intractable and progressive skeletal muscle disease of unknown cause and without effective treatment. The etiology of sIBM is still unknown, however genetic factors, aging, life styles, environmental factors may be involved. sIBM is generally refractory to current therapy, such as steroid or immunosuppressants. To elucidate the pathomechanism of sIBM is the most important way to make therapeutic approach. In this review we estimated the prevalence of sIBM in Japan and discuss the pathomechanism of sIBM.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine.
authors.forename: Naoki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Maki
authors.initials: M
authors.lastname: Tateyama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Warita
authors.forename: Rumiko
authors.initials: R
authors.lastname: Izumi
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
authors.forename: Masashi
authors.initials: M
authors.lastname: Aoki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence