title: Long-term efficacy of 10-12 years after being immunized with Chinese hamster ovary cell derived hepatitis B vaccine in Chinese Rural Communities.
abstract: OBJECTIVE
  To evaluate the long-term efficacy of Chinese hamster ovary (CHO) cell derived hepatitis B vaccine in country community in China.
  
  
  METHODS
  A cross-sectional investigation was carried out. Children who were born between 1997 and 1999 and vaccinated with the three doses of CHO-derived hepatitis B vaccine were selected as study objects. Their serum samples were taken to test for hepatitis B virus (HBV) markers, and the results were compared to that before vaccination. In addition, for HBsAg positive children, their mothers were visited.
  
  
  RESULTS
  1254 Children were enrolled in the study. The prevalence of HBsAg was 0.24% and the vaccine efficacy was 97.0%, similar to that of yeast derived hepatitis vaccines. Among 3 mothers of HBsAg positive children, 2 were HBsAg positive, indicating maternal HBV transmissions.
  
  
  CONCLUSIONS
  The long-term efficacy of the CHO-derived hepatitis B vaccine is good and after vaccination maternal transmission is the most important route of spreading HBV.
authors.affiliation: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changing District, Beijing 100052, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Yu-liang
authors.initials: YL
authors.lastname: Zhao
authors.forename: Jing-chen
authors.initials: JC
authors.lastname: Ma
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Bi
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Shen
mesh_terms: D000818:Animals; D016466:CHO Cells; D002648:Child; D002681:China; D006224:Cricetinae; D003412:Cricetulus; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012424:Rural Population; D013997:Time Factors
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines