title: [CRF-BP and SLC6A4 gene polymorphisms among restrained eaters].
abstract: BACKGROUND
  Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.
  
  
  OBJECTIVE
  To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction.
  
  
  METHODS
  The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.
  
  
  RESULTS
  There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.
  
  
  CONCLUSIONS
  The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
authors.affiliation: Programa de Magíster en Ciencias Mención Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Sanhueza
authors.forename: Christian L
authors.initials: CL
authors.lastname: Herrera
authors.forename: Luis A
authors.initials: LA
authors.lastname: Salazar
authors.forename: Jaime R
authors.initials: JR
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C067133:corticotropin releasing factor-binding protein