title: Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite.
abstract: Establishing whether G protein-coupled receptors (GPCRs) form physiologically relevant functional homo- and heteroligomers in vivo has been a major biochemical challenge. In this issue of Neuron, Kern et al. (2012) investigate whether the anorexigenic effects of D2 dopamine receptors may be a direct consequence of allosteric modulation by Apo-ghrelin receptors.
authors.affiliation: Department of Pharmacology and Toxicology, University of Toronto, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Salahpour
authors.forename: Marc G
authors.initials: MG
authors.lastname: Caron
mesh_terms: D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D054439:Ghrelin / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D054440:Receptors, Ghrelin / Q000378:metabolism*
chemical_list: D018491:Dopamine Agonists; D054439:Ghrelin; D017448:Receptors, Dopamine D2; D054440:Receptors, Ghrelin