title: A single-institution approach to total pelvic exenteration.
abstract: The objective of this study was to describe in detail the technique of total pelvic exenteration. Total pelvic exenteration (TPE) was first described in 1948 by Brunschwig. Since its description, complications of the procedure and surgical innovations have changed the approach to this  radical surgery. We have described our institutional approach and outcomes of TPE. Fifty-four patients underwent TPE between 2004 and 2010 by the Division of Surgical Oncology at the Ohio State University Medical Center. Fifty-three patients have complete medical records available for review.  Outcomes are described and have shaped these techniques. Patients were divided into various groups based on their histology: colorectal (n = 36), gynecologic (n = 6), urologic (n = 5), squamous cell (n = 2), sarcomatous disease (n = 3), and severe infections (n = 1). These were divided into  two groups-colorectal (n = 36) and noncolorectal (n = 17)-for analysis. Demographics, operative time, length of stay, and complication rates were similar between the two groups. The median survival was 21.4 months for the colorectal group and 6.9 months for the noncolorectal group.  Total pelvic exenteration for colorectal tumors has improved survival when compared with patients undergoing exenteration for pelvic malignancies of other origins. Total pelvic exenteration continues to be associated with high morbidity; however, with appropriate patient selection and proper  operative technique, a perioperative mortality of 0 per cent can be achieved.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA. RaviJChokshi@gmail.com
authors.forename: Ravi J
authors.initials: RJ
authors.lastname: Chokshi
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Fowler
authors.forename: David
authors.initials: D
authors.lastname: Cohn
authors.forename: Robert
authors.initials: R
authors.lastname: Bahnson
authors.forename: Joshua
authors.initials: J
authors.lastname: Lumbley
authors.forename: Edward W
authors.initials: EW
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009820:Ohio / Q000453:epidemiology; D018579:Patient Selection; D010385:Pelvic Exenteration / Q000379:methods*; D010386:Pelvic Neoplasms / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome