title: Identification of liguzinediol metabolites in rats by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.
abstract: Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate the in vivo metabolism of liguzinediol. Urine, bile, feces and plasma samples were collected after intravenous administration of 10mg/kg liguzinediol to healthy rats. Altogether seven metabolites were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were mainly transformed by four main metabolic pathways including oxidation, sulfation, glycine conjugation and glucuronidation.
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, People's Republic of China.
authors.forename: Chen-xiao
authors.initials: CX
authors.lastname: Shan
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Wen
authors.forename: Xin-zhi
authors.initials: XZ
authors.lastname: Wang
authors.forename: Yi-hang
authors.initials: YH
authors.lastname: Zhu
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Cui
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D008297:Male; D011719:Pyrazines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: C572935:2,5-dihydroxymethyl-3,6-dimethylpyrazine; D011719:Pyrazines