title: Relationship between CYP1A1 genetic polymorphisms and renal cancer in China.
abstract: OBJECTIVE
  To study the potential role of cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms in the risk of renal cell cancer in Chinese.
  
  
  METHODS
  A total of 181 pathologically-proven renal cancers and 350 controls from the second Xiangya Hospital in Changsha were collected during the period from May 2007 to December 2010. CYP1A1 genetic polymorphisms were genotyped using PCRRFLP. Unconditional logistic regression analysis was performed to analyze their relationship with risk of RCC.
  
  
  RESULTS
  Individuals with Val/Val genotypes had a significantly increased risk of RCC compared those with CYP1A1 IIe/IIe (OR=1.69, 95%CI=1.03-2.85). We also found CYP1A1 Wt/Vt and Vt/Vt to confer a significantly greater risk than CYP1A1 Wt/Wt (Wt/Vt: OR=2.14, 95%CI=1.24-3.45; Vt/Vt: OR=1.78, 95%CI=1.31-3.96). In smokers, a high increase risk of RCC was observed in those with CYP1A1 Val allele and Vt allele (Val allele: OR=2.13, 95%CI=1.40-2.57; Vt allele: OR=3.75, 95%CI=2.43-6.79), but no other significant interactions were found.
  
  
  CONCLUSIONS
  Our study found suggestive evidence that CYP1A1 polymorphisms may play an important role in the etiology of RCC. Cigarette smoking may increase the susceptibility to RCC carcinogenesis in individuals with a high-risk genotype.
authors.affiliation: Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, China. chenjx_2008@yahoo.com.cn
authors.forename: Junxiang
authors.initials: J
authors.lastname: Chen
authors.forename: Meichu
authors.initials: M
authors.lastname: Cheng
authors.forename: Li
authors.initials: L
authors.lastname: Yi
authors.forename: Chang-bin
authors.initials: CB
authors.lastname: Jiang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000235:genetics
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1