title: Reviewing concepts in the immunopathogenesis of psoriasis.
abstract: Insights into the pathogenesis of psoriasis led to the development of therapeutic tools aimed at blocking its immunological trigger. In parallel, cytokines such as the tumor necrosis factor (TNF) have been recognized as playing a crucial role in the pathogenesis of psoriasis and its associated comorbidities. Genetic and immunological studies have contributed effectively towards establishing the currently held concepts regarding this complex disease.
authors.affiliation: Outpatient Psoriasis and Psoriatic Arthritis Research Unit, Teaching Hospital, Federal University of Pernambuco, Brazil. emersonderma@terra.com.br
authors.forename: Emerson de Andrade
authors.initials: Ede A
authors.lastname: Lima
authors.forename: Mariana de Andrade
authors.initials: Mde A
authors.lastname: Lima
mesh_terms: D000938:Antigen-Presenting Cells / Q000502:physiology; D015703:Antigens, CD / Q000276:immunology*; D015704:CD4 Antigens; D016827:CD8 Antigens; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D015704:CD4 Antigens; D016827:CD8 Antigens; D014409:Tumor Necrosis Factor-alpha