title: Ways and means of eukaryotic mRNA decay.
abstract: Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.
authors.affiliation: Department of Molecular Biology, Umeå Universitet, Umeå, Sweden.
authors.forename: Vidya
authors.initials: V
authors.lastname: Balagopal
authors.forename: Lydia
authors.initials: L
authors.lastname: Fluch
authors.forename: Tracy
authors.initials: T
authors.lastname: Nissan
mesh_terms: D021581:Active Transport, Cell Nucleus; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000235:genetics; D005057:Eukaryotic Cells; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D029543:Nucleocytoplasmic Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: C106898:MEX67 protein, S cerevisiae; D026901:Membrane Transport Proteins; C480169:Mtr2 protein, S cerevisiae; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D029701:Saccharomyces cerevisiae Proteins; C026452:messenger ribonucleoprotein; C492382:DBP5 protein, S cerevisiae; D053487:DEAD-box RNA Helicases