title: Ossifying pituitary adenoma co-existing with astrocytoma and pituitary adenoma associated with gangliocytoma: two unusual conditions.
abstract: Bone formation in pituitary adenoma is an extremely rare finding. Only five     previous cases have been published. This is the sixth case report of an     ossifying pituitary adenoma and the first case report of a pituitary adenoma     with bone formation coexisting with WHO grade II astrocytoma. MRI imaging     revealed an unusual eggshell cap-like calcified structure surrounding the tumor.     Histologically, the adenoma contained irregularly anastomosing trabeculae with     well-formed lacunae and osteoblasts along the margins. Our second case concerns     a 25-year-old male patient who presented with complains of off and on headache     for 12 months. MRI (head) revealed a 4x3cm well defined rounded lesion in the     sella and suprasellar extension that was isointense in T1, hyperintense on T2     with cystic areas and homogenous contrast enhancement. On morphological     examination, a cellular tumor admixed with foci of large ganglion cells embedded     in a neuropil stroma was noted. On immunohistochemistry, tumor cells were     focally positive for pancytokeratin, growth hormone and synaptophysin; and     ganglion cells were positive for neurofilament and synaptophysin. No GFAP     positive cells were seen. The Ki67 index was < 1%. Based on these findings, a     diagnosis of gangliocytoma associated with pituitary adenoma was considered.
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Pathology, Lucknow, India. sushilapath@yahoo.com
authors.forename: Sushila
authors.initials: S
authors.lastname: Jaiswal
authors.forename: Mukul
authors.initials: M
authors.lastname: Vij
authors.forename: Awadhesh Kumar
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: Gyan
authors.initials: G
authors.lastname: Chand
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Vijendra
authors.initials: V
authors.lastname: Kumarjain
mesh_terms: D000172:Acromegaly / Q000209:etiology; D000328:Adult; D001254:Astrocytoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005260:Female; D005729:Ganglioneuroma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D019581:Neuropil / Q000473:pathology; D019635:Neurosurgical Procedures; D009999:Ossification, Heterotopic / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016708:Synaptophysin / Q000378:metabolism; D014786:Vision Disorders / Q000209:etiology
chemical_list: D016900:Neurofilament Proteins; D016708:Synaptophysin