title: In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq.
abstract: Antidepressant activity-guided fractionation of the MeOH extract of Valeriana fauriei Briq. roots resulted in the isolation of two new germacrane-type sesquiterpenes (1-2) in addition to seven known ones (3-9). Their structures were elucidated as 1β,10α-dihydroxyl-8α-acetoxyl-10β,11,11-trimethyl-4-formyl-bicyclogermacren-E-4(5)-ene (1), 1β-hydroxyl-8α-acetoxyl-11,11-dimethyl-4-formyl-bicyclogermacren-E-4(5),10(14)-diene (2), bicyclo[8,1,0]5β-hydroxyl-7β-1acetoxyl-5α,11,11'-trimethyl -E-1(10)-ene-4α,15-olide (3), 8α-acetoxyl-3α,4α,10-trihydroxyl-guaia-1(2)-ene-12,6α-olide (4), 2-Ethylhexyl-4-hydroxybenzoate (5), 11αH-gemacra-1(10)E,4Z-diene-3-one-12,6α-olide (6), β-Sitoterol (7), isovaleric acid (8), isoborneol acetate (9), using a combination of UV, IR, mass spectroscopy, 1D and 2D NMR spectroscopy. The antidepressant activity of compounds 1-4 was investigated by the FST on mice. Among them, compounds 3 and 4 showed the significant antidepressant activity (*, P<0.01).
authors.affiliation: College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, PR China.
authors.forename: Xue Gui
authors.initials: XG
authors.lastname: Liu
authors.forename: Pin Yi
authors.initials: PY
authors.lastname: Gao
authors.forename: Guo Sheng
authors.initials: GS
authors.lastname: Wang
authors.forename: Shao Jiang
authors.initials: SJ
authors.lastname: Song
authors.forename: Ling Zhi
authors.initials: LZ
authors.lastname: Li
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.forename: Xin Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Zhen Xue
authors.initials: ZX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045788:Sesquiterpenes, Germacrane / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D013550:Swimming; D014632:Valerian / Q000737:chemistry*
chemical_list: C574478:8alpha-acetoxyl-3alpha,4alpha,10-trihydroxyl-guaia-1(2)-ene-12,6alpha-olide; D000928:Antidepressive Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C574477:bicyclo(8,1,0)5beta-hydroxyl-7beta-1acetoxyl-5alpha,11,11'-trimethyl -E-1(10)-ene-4alpha,15-olide