title: Cellular response of healing tissue to DegraPol tube implantation in rabbit Achilles tendon rupture repair: an in vivo histomorphometric study.
abstract: In tendon rupture repair, improvements such as higher primary repair strength, anti-adhesion and accelerated healing are needed. We developed a potential carrier system of an electrospun DegraPol tube, which was tightly implanted around a transected and conventionally sutured rabbit Achilles tendon. Histomorphometric analysis of the tendon tissue 12 weeks postoperation showed that the tenocyte density, tenocyte morphology and number of inflammation zones were statistically equivalent, whether or not DegraPol tube was implanted; only the collagen fibres were slightly less parallelly orientated in the tube-treated case. Comparison of rabbits that were operated on both hind legs with ones that were operated on only one hind leg showed that there were significantly more inflammation zones in the two-leg cases compared to the one-leg cases, while the implantation of a DegraPol tube had no such adverse effects. These findings are a prerequisite for using DegraPol tube as a carrier system for growth factors, cytokines or stem cells in order to accelerate the healing process of tendon tissue.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University Hospital Zurich, Switzerland. johanna.buschmann@usz.ch
authors.forename: Johanna
authors.initials: J
authors.lastname: Buschmann
authors.forename: Gabriella
authors.initials: G
authors.lastname: Meier-Bürgisser
authors.forename: Eliana
authors.initials: E
authors.lastname: Bonavoglia
authors.forename: Peter
authors.initials: P
authors.lastname: Neuenschwander
authors.forename: Vincent
authors.initials: V
authors.lastname: Milleret
authors.forename: Pietro
authors.initials: P
authors.lastname: Giovanoli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Calcagni
mesh_terms: D000125:Achilles Tendon / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000494:pharmacology* / Q000627:therapeutic use*; D011140:Polyurethanes / Q000494:pharmacology* / Q000627:therapeutic use*; D019919:Prosthesis Implantation; D011817:Rabbits; D012421:Rupture / Q000188:drug therapy / Q000473:pathology; D013708:Tendon Injuries / Q000188:drug therapy* / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: C104154:DegraPol; D011091:Polyesters; D011140:Polyurethanes; D003094:Collagen