title: Harms of screening mammography for breast cancer in Japanese women.
abstract: BACKGROUND
  The US Preventative Services Task Force assesses the efficacy of breast cancer screening by the sum of its benefits and harms, and recommends against routine screening mammography because of its relatively great harms for women aged 40-49 years. Assessment of the efficacy of screening mammography should take into consideration not only its benefits but also its harms, but data regarding those harms are lacking for Japanese women.
  
  
  METHODS
  In 2008 we collected screening mammography data from 144,848 participants from five Japanese prefectures by age bracket to assess the harms [false-positive results, performance of unnecessary additional imaging, fine-needle aspiration cytology (FNA), and biopsy and its procedures].
  
  
  RESULTS
  The rate of cancer detected in women aged 40-49 years was 0.28%. The false-positive rate (9.6%) and rates of additional imaging by mammography (5.8%) and ultrasound (7.3%) were higher in women aged 40-49 years than in the other age brackets. The rates of FNA (1.6%) and biopsy (0.7%) were also highest in women aged 40-49 years. However, they seemed to be lower than the rates reported by the Breast Cancer Surveillance Consortium (BCSC) and other studies in the US.
  
  
  CONCLUSIONS
  The results, although preliminary, indicate the possibility that the harms of screening mammography for Japanese women are less than those for American women.
authors.affiliation: Department of Surgery, Fukui Saiseikai Hospital, 7-1 Funabashi, Wadanakacyou, Fukui, Fukui, 918-8503, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kawai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
authors.forename: Eriko
authors.initials: E
authors.lastname: Tohno
authors.forename: Takao
authors.initials: T
authors.lastname: Yokoe
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
authors.forename: Akira
authors.initials: A
authors.lastname: Tangoku
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ohuchi
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control; D055088:Early Detection of Cancer; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008327:Mammography / Q000009:adverse effects*; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology