title: Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease.
abstract: The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P < 0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD.
authors.affiliation: Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki 036-8562, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Okamoto
authors.forename: Kengo
authors.initials: K
authors.lastname: Imanishi
authors.forename: Noriko
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authors.lastname: Tokui
authors.forename: Teppei
authors.initials: T
authors.lastname: Okamoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Naoaki
authors.initials: N
authors.lastname: Sugiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imai
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Kudo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yoneyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Koie
authors.forename: Noritaka
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authors.lastname: Kaminura
authors.forename: Hisao
authors.initials: H
authors.lastname: Saitoh
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Funyu
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama