title: Aetiology and long-term outcome of juvenile epilepsy in 136 dogs.
abstract: The aetiology and outcome of dogs with juvenile-onset seizures were investigated. One hundred and thirty-six dogs whose first seizure occurred before the age of one year were investigated. One hundred and two dogs were diagnosed with idiopathic epilepsy (IE), 23 with symptomatic epilepsy (SE), nine with reactive seizures (RS) and two with probable symptomatic epilepsy (pSE). The outcome was known in 114 dogs; 37 per cent died or were euthanased as a consequence of seizures. The mean survival time of this population of dogs was 7.1 years. Factors that were significantly associated with survival outcome included the diagnosis of SE and the number of antiepileptic drugs (AEDs) used before investigation. The use of one AED before investigation and a diagnosis of SE were associated with a negative outcome, whereas receiving no AED medications before referral was associated with a longer survival. For dogs with IE, survival time was shortened if the dog was a border collie or with a history of status epilepticus;receiving no AEDs before referral in the IE group was associated with a positive outcome. Seizure-free status was achieved in 22 per cent of dogs diagnosed with IE. While the survival times were longer than previously reported in canine epilepsy, similar remission rates to those reported in childhood epilepsy, where a 70 per cent remission rate is documented, were not seen in the canine juvenile population.
authors.affiliation: Department of Veterinary Science, Small Animal Teaching Hospital, University of Liverpool, Leahurst, Chester High Road, Neston CH64 7TE, UK.
authors.forename: L
authors.initials: L
authors.lastname: Arrol
authors.forename: J
authors.initials: J
authors.lastname: Penderis
authors.forename: L
authors.initials: L
authors.lastname: Garosi
authors.forename: P
authors.initials: P
authors.lastname: Cripps
authors.forename: R
authors.initials: R
authors.lastname: Gutierrez-Quintana
authors.forename: R
authors.initials: R
authors.lastname: Gonçalves
mesh_terms: D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D004285:Dogs; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology / Q000401:mortality / Q000662:veterinary*; D005260:Female; D008297:Male; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000401:mortality / Q000662:veterinary; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants