title: Cochlear function in Ménière's disease.
abstract: OBJECTIVE
  The authors assessed the effectiveness of therapy, common features of pure-tone audiograms, and results of non-invasive electrocochleography before and after mild inhibition of peripheral vestibular function by infrequent administration of single intratympanic gentamicin injections (ITPG) in patients with Ménière's disease (MD).
  
  
  METHODS
  Sixty-two patients with Ménière's disease.
  
  
  METHODS
  Retrospective study.
  
  
  RESULTS
  Out of 62 patients 65% received one injection, 24% two, 6% three, 3% five, and 2% six injections. Between injections, class A vertigo control was obtained after two weeks in all cases. Before ITPG, out of 62 pure-tone threshold audiograms 37 were 'flat'. Average hearing threshold at 2 kHz was significantly better than that of 250, 500, and 0.75 kHz on the affected side.
  
  
  CONCLUSIONS
  Hearing threshold in advanced MD is often flat with a characteristic small peak in the high frequency range, most frequently around 2-3 kHz. Should the complaints be intolerable, single injection ITPG-therapy may be safe and effective.
authors.affiliation: Department of Otolaryngology, County Hospital, Krems, Austria. bukibela@hotmail.com
authors.forename: Bela
authors.initials: B
authors.lastname: Büki
authors.forename: Heinz
authors.initials: H
authors.lastname: Jünger
authors.forename: Paul
authors.initials: P
authors.lastname: Avan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001300:Audiometry, Evoked Response; D003051:Cochlea / Q000187:drug effects*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage*; D012189:Retrospective Studies; D014717:Vertigo / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005839:Gentamicins; D011500:Protein Synthesis Inhibitors