title: An endogenous bile acid and dietary sucrose from skin secretions of alkaloid-sequestering poison frogs.
abstract: The skins of Madagascar poison frogs (Mantella) and certain Neotropical poison frogs (Epipedobates, Dendrobates) secrete the new bile acid tauromantellic acid (1), which was found in both wild-caught and captive-born frogs. This is the first molecule of endogenous origin detected in skin secretions from these taxa. Sucrose was also detected in secretions from wild-caught Mantella but not in captive-born frogs, suggesting a dietary origin.
authors.affiliation: School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. frogchemistry@gmail.com
authors.forename: Valerie C
authors.initials: VC
authors.lastname: Clark
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Martin
authors.initials: M
authors.lastname: Zeller
authors.forename: William
authors.initials: W
authors.lastname: Ronto
authors.forename: James
authors.initials: J
authors.lastname: Rocca
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Dossey
authors.forename: Daniel
authors.initials: D
authors.lastname: Rakotondravony
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
authors.forename: Chris
authors.initials: C
authors.lastname: Shaw
mesh_terms: D000470:Alkaloids; D000818:Animals; D001001:Anura; D001647:Bile Acids and Salts / Q000032:analysis; D019422:Dietary Sucrose / Q000032:analysis*; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012867:Skin / Q000378:metabolism
chemical_list: D000470:Alkaloids; D001647:Bile Acids and Salts; D019422:Dietary Sucrose; C571987:tauromantellic acid