title: Association between genetic variations of vascular endothelial growth factor receptor 2 and glioma in the Chinese Han population.
abstract: Tumor angiogenesis, which is an important step in the development of cancer, is directly regulated by vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we examined the association of five potentially functional VEGFR-2 polymorphisms with glioma risk in a Chinese Han population. Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P = 0.006, 0.005, and 0.012, respectively). Both haplotype and diplotype analyses consistently revealed that subjects carrying two copies of the haplotype "CGT" had a 42% reduced glioma risk compared with their respective noncarriers. Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility.
authors.affiliation: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Weimin
authors.initials: W
authors.lastname: Wang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xingjie
authors.forename: Xiao
authors.initials: X
authors.lastname: Song
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Zhou
authors.initials: Z
authors.lastname: Keke
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005910:Glioma / Q000208:ethnology* / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*; D055815:Young Adult
chemical_list: D040301:Vascular Endothelial Growth Factor Receptor-2