title: Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity.
abstract: Convolvulus pluricaulis Choisy is a perennial wild herb commonly found on sandy & rocky areas under xerophytic conditions in northern India. It is a reputed drug of ayurveda and reported to posses antioxidant, brain tonic, nervine tonic, laxative and has been used in anxiety, neurosis, epilepsy, insomnia, burning sensation, oedema and urinary disorders. In the present study, methanolic extract of whole plant of Convolvulus pluricaulis Choisy was evaluated for antioxidant activity by using 1, 1-diphenyl-2-picryl- hydrazyl (DPPH) free radical scavenging model and anticonvulsant activity by using maximal electroshock seizure model. In antioxidant activity, ascorbic acid was used as standard agent while results of anticonvulsant studies were compared with phenytoin. Results of antioxidant activity have demonstrated significant free radical scavenging effect for methanolic extract of Convolvulus pluricaulis Choisy. IC50 value of methanolic extract was observed as 41.00μg/ml as compared to 2.03μg/ml of ascorbic acid. Methanolic extract of C. pluricaulis was evaluated for anticonvulsant activity at 250, 500 and 1000mg/kg. Experimental results have shown that at the dose of 500 and 1000mg/kg, C. pluricaulis didn't abolish the hind limb extension, but reduced the mean recovery time from convulsion.
authors.affiliation: Ram-Eesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India.
authors.forename: Sristi
authors.initials: S
authors.lastname: Verma
authors.forename: Reema
authors.initials: R
authors.lastname: Sinha
authors.forename: Puspendra
authors.initials: P
authors.lastname: Kumar
authors.forename: Faizal
authors.initials: F
authors.lastname: Amin
authors.forename: Jainendra
authors.initials: J
authors.lastname: Jain
authors.forename: Shivani
authors.initials: S
authors.lastname: Tanwar
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D031254:Convolvulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018514:Plant Structures; D012640:Seizures / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D000975:Antioxidants; D010936:Plant Extracts