title: Prenatal exposure to mercury and infant neurodevelopment in a multicenter cohort in Spain: study of potential modifiers.
abstract: Vulnerability of the central nervous system to mercury is increased during early development. This study aimed to evaluate whether cord blood total mercury levels may have a negative effect on both mental and psychomotor development in a maternal-birth cohort from moderate-high fish consumption areas. Study subjects were 1,683 child participants in the INMA (Environment and Childhood) Project from 4 areas of Spain between 2003 and 2010. Cord blood total mercury levels were analyzed by atomic absorption spectrometry. Infant neurodevelopment was assessed around age 14 months by the Bayley Scales of Infant Development. Sociodemographic, lifestyle, and dietary information was obtained by questionnaire during pregnancy. The geometric mean of total mercury levels was 8.4 μg/L (95% confidence interval (CI): 8.1, 8.7). In multivariate analysis, a doubling in total mercury levels did not show an association with mental (β = 0.1, 95% CI: -0.68, 0.88) or psychomotor (β = -0.05, 95% CI: -0.79, 0.68) developmental delay; however, stratified findings by sex suggest a negative association between prenatal exposure to total mercury and psychomotor development among female infants (β = -1.09, 95% CI: -2.21, 0.03), although follow-up is required to confirm these results.
authors.affiliation: Centre for Public Health Research, Valencia, Spain. llop_sab@gva.es
authors.forename: Sabrina
authors.initials: S
authors.lastname: Llop
authors.forename: Mònica
authors.initials: M
authors.lastname: Guxens
authors.forename: Mario
authors.initials: M
authors.lastname: Murcia
authors.forename: Aitana
authors.initials: A
authors.lastname: Lertxundi
authors.forename: Rosa
authors.initials: R
authors.lastname: Ramon
authors.forename: Isolina
authors.initials: I
authors.lastname: Riaño
authors.forename: Marisa
authors.initials: M
authors.lastname: Rebagliato
authors.forename: Jesus
authors.initials: J
authors.lastname: Ibarluzea
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardon
authors.forename: Jordi
authors.initials: J
authors.lastname: Sunyer
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
mesh_terms: D015331:Cohort Studies; D002658:Developmental Disabilities / Q000097:blood / Q000139:chemically induced*; D004034:Diet Surveys; D015987:Effect Modifier, Epidemiologic; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005506:Food Contamination; D006801:Humans; D007223:Infant; D016014:Linear Models; D008297:Male; D008628:Mercury / Q000097:blood / Q000633:toxicity*; D015999:Multivariate Analysis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000139:chemically induced*; D011581:Psychological Tests; D011596:Psychomotor Disorders / Q000097:blood / Q000139:chemically induced*; D011597:Psychomotor Performance / Q000187:drug effects; D017747:Seafood; D012737:Sex Factors; D013030:Spain; D014874:Water Pollutants, Chemical / Q000097:blood / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D008628:Mercury