title: Prostaglandin modulation of phorbol ester skin tumor promotion.
abstract: TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2alpha enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.
authors.affiliation: Biology Division, Oak Ridge National Laboratory, University of Tennessee Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, TN 37830, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Fischer
authors.forename: G L
authors.initials: GL
authors.lastname: Gleason
authors.forename: L G
authors.initials: LG
authors.lastname: Hardin
authors.forename: J S
authors.initials: JS
authors.lastname: Bohrman
authors.forename: T J
authors.initials: TJ
authors.lastname: Slaga
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D003043:Cocarcinogenesis; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D051379:Mice; D018632:Mice, Inbred SENCAR; D010120:Oxytocics / Q000494:pharmacology; D010212:Papilloma / Q000139:chemically induced*; D011453:Prostaglandins / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D010120:Oxytocics; D011453:Prostaglandins; D016718:Arachidonic Acid; D015237:Dinoprost; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate