title: Local signaling within stem cell niches: insights from Drosophila.
abstract: Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term changes that affect the whole organism, such as variations in nutrient availability or aging. In contrast, local signaling regulates tissue maintenance by balancing stem cell self-renewal with differentiation under homeostatic conditions and in response to local damage. In this review, we highlight the role of the JAK-STAT pathway in two Drosophila stem cell systems, the testis and intestine, and compare and contrast how activation of this pathway leads to tissue maintenance under both homeostatic conditions and in response to stress or injury.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, United States.
authors.forename: Luís Pedro F
authors.initials: LP
authors.lastname: Resende
authors.forename: D Leanne
authors.initials: DL
authors.lastname: Jones
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D004330:Drosophila / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D053612:Janus Kinases / Q000378:metabolism*; D008297:Male; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D050791:STAT Transcription Factors; D053612:Janus Kinases