title: Invasive Candida infections in children: the clinical characteristics and species distribution and antifungal susceptibility of Candida spp.
abstract: The aims of the study were to examine the distribution of Candida spp. isolated from sterile body sites, the antifungal susceptibility of the isolates to amphotericin B, fluconazole, voriconazole, and caspofungin, and factors affecting mortality with invasive Candida infections in children. Thirty-five children with invasive candidiasis between January 2004 and January 2008 were evaluated retrospectively. The antifungal susceptibility of isolated Candida species was studied by Etest. Of the invasive Candida infections, 65.7% were due to C. albicans. The second most common isolated species was C. parapsilosis (11.4%). The rates of resistance to fluconazole, amphotericin B and voriconazole were 8.5%, 2.8% and 5.7%, respectively. Caspofungin was the most effective antifungal agent. 22.8% of the patients died in the first 30 days. In univariate analyses, increased mortality was associated with stay in the intensive care unit, the presence of central venous catheter (CVC), failure to remove CVC, and mechanical ventilation.
authors.affiliation: Department of Pediatric Infectious Diseases, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Nurşen
authors.initials: N
authors.lastname: Belet
authors.forename: Ergin
authors.initials: E
authors.lastname: Ciftçi
authors.forename: Derya
authors.initials: D
authors.lastname: Aysev
authors.forename: Haluk
authors.initials: H
authors.lastname: Güriz
authors.forename: Zümrüt
authors.initials: Z
authors.lastname: Uysal
authors.forename: Nurdan
authors.initials: N
authors.lastname: Taçyildiz
authors.forename: Begüm
authors.initials: B
authors.lastname: Atasay
authors.forename: Figen
authors.initials: F
authors.lastname: Doğu
authors.forename: Tanil
authors.initials: T
authors.lastname: Kendirli
authors.forename: Zarife
authors.initials: Z
authors.lastname: Kuloğlu
authors.forename: Erdal
authors.initials: E
authors.lastname: Ince
authors.forename: Ulker
authors.initials: U
authors.lastname: Doğru
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D002405:Catheterization, Central Venous; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents