title: [Clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation].
abstract: OBJECTIVE
  To investigate the effects of administration of dexmedetomidine in anaesthesia for esophageal cancer operation.
  
  
  METHODS
  100 patients (ASAI-II) who were undergoing to esophageal cancer operation were randomly divided into control group (group A) and dexmedetomidine group (group B) (n = 50). The scheme of induction and maintenance of aesthesia of the two groups were identical. Patients in group B administered dexmedetomidine at a dose of 1 microg/kg over 10 min and patients in group A were given a placebo infusion of normal saline. Patients in group B administered dexmedetomidine at a dose of 0.4 microg/(kg x h) was injected and stoped at 30 min by the end of operation. Mean artery pressure (MAP) and heart rate (HR) were detected before induction (T0), induction (T1), 1 min after extubation (T2), 5 min after extubation (T3) and 10 min after extubation (T4) Propofol comsumption, fentanlyl comsumption, and side effects were recorded as well.
  
  
  RESULTS
  The results showed that MAP and HR (T0, T1, T2, T3, T4) in group B were significantly different from those in group A which fluctuated more markedly (P < 0.05). Propofol comsumption in group A was much more than that in group B (P < 0.05). Incidence of pharynx and larynx ache and restlessness were higher in group A than those in group B (P < 0.05).
  
  
  CONCLUSIONS
  Dexmedetomidine could effectively reduce the cardiovascular response to incubation and extubation in esophageal cancer operation patients. Propofol comsumption, fentanlyl comsumption and side effects were reduceed as well.
authors.affiliation: Department of Anesthesiology, the First Hospital of Huai'an, Affiliated hospital of Nanjing Medical University, Huai'an 223300, China. liuhailin_1971@163.com
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Liu
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Guo-Long
authors.initials: GL
authors.lastname: Zheng
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D020927:Dexmedetomidine / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage
chemical_list: D000759:Adjuvants, Anesthesia; D018712:Analgesics, Non-Narcotic; D018686:Anesthetics, Intravenous; D020927:Dexmedetomidine; D005283:Fentanyl; D015742:Propofol