title: Lymphocyte blastogenic responses to food antigens in cats showing clinical symptoms of food hypersensitivity.
abstract: Three cats were diagnosed as having food hypersensitivity by food elimination and oral food provocation tests. Twelve allergenic food ingredients were identified by oral food provocation test in the 3 cats. Of the 12 food ingredients, 9 offending food antigens were shown to be positive in a lymphocyte stimulation test; however, none of them were positive in antigen-specific IgE testing, and only four food antigens were positive in intradermal testing. The stimulation indices in the lymphocyte stimulation tests for the 9 food ingredients were found to be decreased after the cats were fed elimination diets. The present study demonstrates that the lymphocyte stimulation test reflects an immunologic reaction involved in food hypersensitivity and can help identify allergenic food ingredients in feline food hypersensitivity.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Rinei
authors.initials: R
authors.lastname: Ishida
authors.forename: Keigo
authors.initials: K
authors.lastname: Kurata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Masuda
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D002415:Cats; D003938:Diagnostic Techniques, Digestive System / Q000662:veterinary*; D004032:Diet / Q000009:adverse effects; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male
chemical_list: D000941:Antigens; D007073:Immunoglobulin E