title: Survivin gene promoter polymorphism -31G/C as a risk factor for keratocystic odontogenic tumor development.
abstract: Several single nucleotide polymorphisms in survivin gene promoters, notably -31G/C, have been shown to modulate the expression and activity of the survivin protein. Consequently, the -31G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The aim of this study was to investigate a possible association between the -31G/C polymorphism and the risk for keratocystic odontogenic tumor (KCOT) development. DNA from 52 biopsy specimens of KCOTs and from 82 buccal swabs of healthy individuals was subjected to PCR restriction fragment length polymorphism analysis to identify individual genotypes. The distribution of genotypes in KCOT and control groups, respectively, was: GG: 30 (57.7%) vs. 26 (31.7%); CG: 17 (32.7%) vs. 45 (54.9%); and CC: 5 (9.6%) vs. 11 (13.4%), respectively. These differences were statistically significant. The G allele was more common in the KCOT group than in the control group: 76 (74%) vs. 96 (59%), respectively. Logistic regression analysis showed that GC heterozygotes had a considerably decreased susceptibility for KCOTs compared with GG homozygotes. The same was true for GC+CC vs. GG. The GG genotype of the -31G/C polymorphism might be a risk factor for KCOT development.
authors.affiliation: University of Belgrade, School of Dentistry, Clinic of Oral Surgery, Belgrade, Serbia. miroslav.andric@stomf.bg.ac.rs
authors.forename: Miroslav
authors.initials: M
authors.lastname: Andric
authors.forename: Nađa
authors.initials: N
authors.lastname: Nikolic
authors.forename: Marija
authors.initials: M
authors.lastname: Boskovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Milicic
authors.forename: Sanja
authors.initials: S
authors.lastname: Skodric
authors.forename: Gordana
authors.initials: G
authors.lastname: Basta Jovanovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Milasin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006147:Guanine; D006720:Homozygote; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D009808:Odontogenic Tumors / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D012307:Risk Factors; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D006147:Guanine; D003596:Cytosine