title: The formation of azoxymethane, a colon carcinogen, during the chemical oxidation of methylamine.
abstract: Simple chemical oxidation of methylamine in aqueous solution or in methanol leads to the formation of significant amounts of azoxymethane, a strong carcinogen in rodents. Methods, including high pressure liquid chromatography, differential pulse polarography and gas chromatography-mass spectrometry, used for the identification of the carcinogen, are described.
authors.affiliation: Division of Molecular Biology and Pharmacology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Fiala
mesh_terms: D001397:Azoxymethane / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D002273:Carcinogens / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms / Q000139:chemically induced*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D000432:Methanol / Q000737:chemistry*; D008744:Methylamines / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D011048:Polarography
chemical_list: D002273:Carcinogens; D008744:Methylamines; C027451:methylamine; D001397:Azoxymethane; D010100:Oxygen; D000432:Methanol