title: D1/D5 dopamine receptors modulate spatial memory formation.
abstract: We investigated the effect of the intra-CA1 administration of the D1/D5 receptor antagonist SCH23390 and the D1/D5 receptor agonist SKF38393 on spatial memory in the water maze. When given immediately, but not 3h after training, SCH23390 hindered long-term spatial memory formation without affecting non-spatial memory or the normal functionality of the hippocampus. On the contrary, post-training infusion of SKF38393 enhanced retention and facilitated the spontaneous recovery of the original spatial preference after reversal learning. Our findings demonstrate that hippocampal D1/D5 receptors play an essential role in spatial memory processing.
authors.affiliation: Laboratório de Neuroquímica & Neurofisiologia da Memória, Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica de Rio Grande do Sul, Av. Ipiranga, 6690-2nd floor, 90610-000 Porto Alegre, RS, Brazil.
authors.forename: Weber C N
authors.initials: WC
authors.lastname: da Silva
authors.forename: Cristiano C
authors.initials: CC
authors.lastname: Köhler
authors.forename: Andressa
authors.initials: A
authors.lastname: Radiske
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001552:Benzazepines / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D050641:Receptors, Dopamine D5 / Q000378:metabolism*; D012193:Reversal Learning / Q000187:drug effects / Q000502:physiology
chemical_list: D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D050641:Receptors, Dopamine D5; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine