title: Indole affects biofilm formation in bacteria.
abstract: Biofilm is bacterial population adherent to each other and to surfaces or interfaces, often enclosed by a matrix. Various biomolecules contribute to the establishment of biofilms, yet the process of building a biofilm is still under active investigation. Indole is known as a metabolite of amino acid tryptophan, which, however, has recently been proved to participate in various aspects of bacterial life including virulence induction, cell cycle regulation, acid resistance, and especially, signaling biofilm formation. Moreover, indole is also proposed to be a novel signal involved in quorum sensing, a bacterial cooperation behavior sometimes concerning the biofilm formation. Here the signaling role and molecular mechanism of indole on bacterial biofilm formation are reviewed, as well discussed is its relation to bacterial living adaptivity.
authors.affiliation: School of Life Science, Beijing Institute of Technology, 5# Zhongguancun Nandajie, Beijing, 100081 People's Republic of China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Hu
authors.forename: Can
authors.initials: C
authors.lastname: Zhang
authors.forename: Yufei
authors.initials: Y
authors.lastname: Mu
authors.forename: Qianwei
authors.initials: Q
authors.lastname: Shen
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Feng