title: Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents.
abstract: The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.
authors.affiliation: School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Robert B P
authors.initials: RB
authors.lastname: Elmes
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Erby
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Bright
authors.forename: D Clive
authors.initials: DC
authors.lastname: Williams
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
mesh_terms: D002470:Cell Survival; D003287:Contrast Media / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D049408:Luminescent Agents / Q000737:chemistry*; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D049408:Luminescent Agents; D053644:Naphthalimides; D011725:Pyridines; D012428:Ruthenium