title: Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient.
abstract: We present the case of a 43-year-old man diagnosed with HLA-B39-positive spondyloarthritis who developed cutaneous lesions consistent with cutaneous polyarteritis nodosa (CPN). Previous studies indicated an elevated incidence of HLA-B39 in HLA-B27-negative Japanese patients with spondyloarthritis. This case suggested that CPN may also occur in association with forms of HLA-B39-positive spondyloarthritis. The rarity of this association is emphasized. Therapy with corticosteroid and methotrexate improved both the cutaneous lesions and the clinical symptoms of spondyloarthritis.
authors.affiliation: Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan. hiro-n@marianna-u.ac.jp
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Nakano
authors.forename: Seido
authors.initials: S
authors.lastname: Ooka
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Shibata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takakuwa
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tonooka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Maeda
authors.forename: Yoshioki
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Kiyokawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nagafuchi
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Yamada
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005938:Glucocorticoids / Q000627:therapeutic use; D059946:HLA-B39 Antigen / Q000097:blood*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply / Q000473:pathology; D012871:Skin Diseases; D025241:Spondylarthritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D059946:HLA-B39 Antigen; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008727:Methotrexate