title: No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients.
abstract: OBJECTIVE
  To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection.
  
  
  METHODS
  We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed.
  
  
  RESULTS
  The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups.
  
  
  CONCLUSIONS
  The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yan
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Gao
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
authors.forename: Tian-Chen
authors.initials: TC
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.forename: Hua-Fa
authors.initials: HF
authors.lastname: Yin
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D050838:Interferon Regulatory Factor-3 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3