title: Novel delivery strategies for glioblastoma.
abstract: Brain tumors--particularly glioblastoma multiforme--pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insufficient with nearly universal recurrence. A major reason for this failure is the difficulty of delivering therapeutic agents to the brain: better delivery approaches are needed to improve treatment. In this article, we summarize recent progress in drug delivery to the brain, with an emphasis on convection-enhanced delivery of nanocarriers. We examine the potential of new delivery methods to permit novel drug- and gene-based therapies that target brain cancer stem cells and discuss the use of nanomaterials for imaging of tumors and drug delivery.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
authors.forename: Jiangbing
authors.initials: J
authors.lastname: Zhou
authors.forename: Kofi-Buaku
authors.initials: KB
authors.lastname: Atsina
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Himes
authors.forename: Garth W
authors.initials: GW
authors.lastname: Strohbehn
authors.forename: W Mark
authors.initials: WM
authors.lastname: Saltzman
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems / Q000379:methods*; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry; D014411:Neoplastic Stem Cells / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents