title: Whispering gallery modes in standard optical fibres for fibre profiling measurements and sensing of unlabelled chemical species.
abstract: Whispering gallery mode resonances in liquid droplets and microspheres have attracted considerable attention due to their potential uses in a range of sensing and technological applications. We describe a whispering gallery mode sensor in which standard optical fibre is used as the whispering gallery mode resonator. The sensor is characterised in terms of the response of the whispering gallery mode spectrum to changes in resonator size, refractive index of the surrounding medium, and temperature, and its measurement capabilities are demonstrated through application to high-precision fibre geometry profiling and the detection of unlabelled biochemical species. The prototype sensor is capable of detecting unlabelled biomolecular species in attomole quantities.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Rd, Oxford OX1 3TA, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Boleininger
authors.forename: Thomas
authors.initials: T
authors.lastname: Lake
authors.forename: Sophia
authors.initials: S
authors.lastname: Hami
authors.forename: Claire
authors.initials: C
authors.lastname: Vallance
mesh_terms: D000388:Air; D001710:Biotin / Q000032:analysis; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D008962:Models, Theoretical; D055100:Optical Fibers; D012031:Refractometry; D012680:Sensitivity and Specificity; D019809:Streptavidin / Q000032:analysis; D014867:Water
chemical_list: D014867:Water; D001710:Biotin; D019809:Streptavidin