title: Facile synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via Brønsted acid catalyzed sp3 C-H functionalization.
abstract: Brønsted acid catalyzed functionalization of sp(3) C-H bonds in 2-methyl azaarenes has been achieved in the reaction with isatins. This method provides facile synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step in moderate to good yields.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Niu
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Liang
authors.forename: Xingwei
authors.initials: X
authors.lastname: Li
mesh_terms: D000143:Acids / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis*; D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D006900:Hydroxylation; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D000078183:Oxindoles
chemical_list: D000143:Acids; D001372:Aza Compounds; D001688:Biological Products; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole