title: Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: a genetic association study.
abstract: We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "pain-protective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The "pain-protective" 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender, and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently, the role of GTP cyclohydrolase 1 in painful HIV-associated sensory neuropathy remains possible.
authors.affiliation: Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. antonia.wadley@wits.ac.za
authors.forename: Antonia L
authors.initials: AL
authors.lastname: Wadley
authors.forename: Zané
authors.initials: Z
authors.lastname: Lombard
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Cherry
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
authors.forename: Peter R
authors.initials: PR
authors.lastname: Kamerman
mesh_terms: D000328:Adult; D005260:Female; D006136:GTP Cyclohydrolase / Q000235:genetics*; D056726:Genetic Association Studies; D015658:HIV Infections / Q000150:complications*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000235:genetics*; D010146:Pain / Q000235:genetics*; D011110:Polymorphism, Genetic; D013019:South Africa
chemical_list: D006136:GTP Cyclohydrolase