title: Selective palladium-catalyzed C-F activation/carbon-carbon bond formation of polyfluoroaryl oxazolines.
abstract: A selective palladium-catalyzed Suzuki-Miyaura coupling reaction of polyfluorophenyl oxazolines through ortho C-F activation is described. It was found that reactions with DPPF as the ligand occurred much faster than those with other ligands. A variety of arylboronic acids including challenging functionalized arylboronic acids such as enolizable ketones, aldehyde, cyano, ester, and trifluoromethyl groups were tolerated with the reaction conditions.
authors.affiliation: Key Laboratory of Organofluorine Chfigemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
authors.forename: Daohong
authors.initials: D
authors.lastname: Yu
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
authors.forename: Long
authors.initials: L
authors.lastname: Lu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001897:Boronic Acids; D004952:Esters; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D008024:Ligands; D010080:Oxazoles; D005461:Fluorine; D010165:Palladium; D002244:Carbon