title: Neuroprotective and antiamnestic effect of nerve growth factor dipeptide mimetic GK-2 in experimental ischemic infarction of brain cortex.
abstract: The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashuk
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000601:surgery; D020520:Brain Infarction / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002540:Cerebral Cortex / Q000378:metabolism; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy*; D008297:Male; D020932:Nerve Growth Factor / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D051381:Rats
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; D010455:Peptides; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D020932:Nerve Growth Factor