title: Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques.
abstract: An efficient and convenient solution-phase synthesis of a 1H-1,2,4-triazole library with potential agrochemical activity is reported employing microwave-assisted organic synthesis (MAOS) and continuous-flow microfluidic synthetic methods starting from commercially available 3,5-dibromo-1H-1,2,4-triazole (1). MAOS was used for the synthesis of 5-amino-3-bromo-1,2,4-triazole analogs 3 and for their 3-aryl derivatives 4 via Suzuki-Miyaura coupling with polymer-supported catalyst. A microfluidic hydrogenation reactor integrated into an automated parallel synthesis platform was built and utilized for the reductive dehalogenation reactions providing 5-aminotriazoles (5).
authors.affiliation: AMRI Hungary Zrt., Záhony u. 7., Budapest, 1035, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Szommer
authors.forename: András
authors.initials: A
authors.lastname: Lukács
authors.forename: József
authors.initials: J
authors.lastname: Kovács
authors.forename: Miklós J
authors.initials: MJ
authors.lastname: Szabó
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hoffmann
authors.forename: Monika H
authors.initials: MH
authors.lastname: Schmitt
authors.forename: János
authors.initials: J
authors.lastname: Gerencsér
mesh_terms: D000588:Amines / Q000737:chemistry; D001965:Bromides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D044085:Microfluidics / Q000379:methods*; D008872:Microwaves; D008970:Molecular Weight; D012212:Rheology; D012997:Solvents / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000588:Amines; D001965:Bromides; D012997:Solvents; D014230:Triazoles; C045575:1,2,4-triazole