title: Successful treatment of childhood hypocellular acute myeloid leukemia.
abstract: Hypocellular acute myeloid leukemia (AML) is extremely rare in childhood. We report on a 7-year-old girl with hypocellular AML who was treated successfully with granulocyte-colony stimulating factor (G-CSF) and combined chemotherapy. High-dose G-CSF induced complete remission and she subsequently received reduced intensity conditioning and unrelated cord blood transplantation; however, this resulted in early rejection. After a complete hematological recovery, she received 3 courses of combination chemotherapy oriented toward AML. She has remained in complete remission for over 1 year after the completion of the therapy. G-CSF effectively induced remission, and combination chemotherapy has been proven to be feasible for patients with childhood hypocellular AML.
authors.affiliation: Department of Pediatrics †Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. ymasaki@sapmed.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hori
authors.forename: Naoki
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Keita
authors.initials: K
authors.lastname: Igarashi
authors.forename: Kotoe
authors.initials: K
authors.lastname: Iesato
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Noguchi
authors.forename: Hayato
authors.initials: H
authors.lastname: Miyachi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000628:therapy*; D008297:Male
chemical_list: D016179:Granulocyte Colony-Stimulating Factor