title: Meta-analysis of the association between the insertion/deletion polymorphism in ACE gene and coronary heart disease among the Chinese population.
abstract: OBJECTIVE
  Many studies have suggested that the angiotensin-converting enzyme (ACE) gene might be involved in the development of coronary heart disease (CHD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the association between ACE I/D polymorphism and CHD susceptibility among the Chinese population.
  
  
  METHODS
  Published literature from PubMed, EMBASE, CNKI and Wan Fang Data was searched. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a fixed or random-effects model.
  
  
  RESULTS
  Forty-six studies (5215 cases and 4782 controls) were identified. The results from the meta-analysis indicated statistically significant association between ACE I/D polymorphism and CHD risk under all three genetic models (co-dominant model DD vs. II: OR=2.40, 95% CI 2.02-2.84, DI vs. II: OR=1.19, 95% CI 1.05-1.34; dominant model: OR=1.51, 95% CI 1.33-1.70; recessive model: OR=2.14, 95% CI 1.86-2.45; multiplicative model: OR=1.57, 95% CI 1.43-1.72 ). Further sensitivity analysis confirmed the significant association.
  
  
  CONCLUSIONS
  The meta-analysis indicated a significant association between ACE I/D polymorphism and CHD susceptibility among the Chinese population. However, further studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the association.
authors.affiliation: Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan, China. liangzhou0731@163.com
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Weihua
authors.initials: W
authors.lastname: Shen
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000201:enzymology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A