title: Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis.
abstract: Status of certain oxidative stress indices and zinc, copper and iron concentrations in blood were estimated in camel with liver cystic echinococcosis. In comparison to healthy control, the index of serum lipid peroxidation assessed by the malondialdehyde (MDA) level was significantly higher in the parasitized group. However, mean serum total antioxidant status (TAS) and erythrocyte glutathione peroxidase (GPx) were significantly lower in the parasitized group. Serum zinc concentration in camels with liver cystic echinococcosis was significantly lower than healthy control. In parasitized camels, a significant positive correlation of MDA with gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST) and bilirubin was observed. By contrast, MDA was inversely correlated with the values of packed cell volume (PCV), serum albumin and zinc. From the present study, it was concluded that cystic echinococcosis in camel is associated with oxidative stress. The resulting oxidative stress seems to have a role in the injury of hepatocytes, changes of trace elements and destruction of erythrocytes.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. heidarpour@um.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Heidarpour
authors.forename: M
authors.initials: M
authors.lastname: Mohri
authors.forename: H
authors.initials: H
authors.lastname: Borji
authors.forename: E
authors.initials: E
authors.lastname: Moghdass
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000740:Anemia / Q000662:veterinary; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin; D015415:Biomarkers; D002162:Camelus; D004444:Echinococcosis, Hepatic / Q000473:pathology / Q000662:veterinary*; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology* / Q000469:parasitology; D008315:Malondialdehyde / Q000097:blood; D008670:Metals; D018384:Oxidative Stress; D012709:Serum Albumin; D014131:Trace Elements
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008670:Metals; D012709:Serum Albumin; D014131:Trace Elements; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin