title: Gastric malignant schwannoma presenting with upper gastrointestinal bleeding: a case report.
abstract: BACKGROUND
  We report a case of gastric malignant schwannoma presenting with gastrointestinal bleeding.
  
  
  METHODS
  A 70-year-old Japanese man presented with gastrointestinal bleeding to our hospital. Gastrointestinal endoscopy revealed a protruding lesion in the gastric body. Hematoxylin and eosin staining of biopsy specimens from this lesion revealed sheets of spindle cells. Immunohistochemistry revealed that these cells were positive for S-100 protein and negative for c-Kit and smooth muscle actin. Because mitosis was diffusely visible, this tumor was diagnosed as a gastric malignant schwannoma. Distal gastrectomy with lymph node dissection was performed and the patient's postoperative course was uneventful. However, five months after the surgery, he died from multiple liver metastases.
  
  
  CONCLUSIONS
  Cases of gastric malignant schwannoma have rarely been reported. The efficacy of surgical resection and postoperative prognosis continues to remain unclear and should be investigated further.
authors.affiliation: Department of Gastrointestinal Surgery, Osaka City General Hospital, 2-13-22, Miyakojima Hondori, Miyakojima, Osaka City, Osaka, 534-0021, Japan. kayo19780419@yahoo.co.jp.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takemura
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Mamiko
authors.initials: M
authors.lastname: Takii
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Sakurai
authors.forename: Akishige
authors.initials: A
authors.lastname: Kanazawa