title: Association of platelet activation with vascular cognitive impairment: implications in dementia development?
abstract: Cardiovascular risk factors are associated with coronary artery disease (CAD) and with cognitive dysfunction. However, the precise pathogenic mechanisms responsible for this association remain elusive. In the present study, CAD patients with cognitive impairment showed significantly higher platelet activation compared with CAD patients without cognitive impairment. In addition, we identified platelet activity to be a significant independent predictor for the severity of cognitive impairment in these patients. We discuss the link between platelet hyperactivity and dementia (including Alzheimer`s disease) based on the literature and our findings. We also discuss the potential mechanisms involved. This link may become a therapeutic option.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Stellos
authors.forename: Niki
authors.initials: N
authors.lastname: Katsiki
authors.forename: Prokopia
authors.initials: P
authors.lastname: Tatsidou
authors.forename: Boris
authors.initials: B
authors.lastname: Bigalke
authors.affiliation: Department of Internal Medicine III - Cardiology and Molecular Cardiology, Goethe University of Frankfurt, Theodor-Ster-Kai 7, Frankfurt/Main D-60590, Germany. konstantinos.stellos@kgu.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Laske
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000209:etiology; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications*; D003704:Dementia / Q000097:blood / Q000209:etiology*; D006801:Humans; D015539:Platelet Activation