title: Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells.
abstract: Mn(III)-loaded apoferritin is promptly reduced to Mn(II)-apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
authors.affiliation: Center for Molecular Imaging, Department of Chemistry IFM, University of Torino, via Nizza 52, Torino, Italy.
authors.forename: Ibolya
authors.initials: I
authors.lastname: Szabó
authors.forename: Simonetta Geninatti
authors.initials: SG
authors.lastname: Crich
authors.forename: Diego
authors.initials: D
authors.lastname: Alberti
authors.forename: Ferenc K
authors.initials: FK
authors.lastname: Kálmán
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
mesh_terms: D000818:Animals; D001052:Apoferritins / Q000737:chemistry*; D045744:Cell Line, Tumor; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice
chemical_list: D008543:Melanins; D008345:Manganese; D001052:Apoferritins