title: Chemical interference of biological systems with natural products.
abstract: Chemical compounds isolated from natural sources offer unique opportunities to understand life on a molecular level. In this account, an overview over different natural products investigated in our research group over the last decade is presented. We have shown that protein localization  in living cells can be controlled by anguinomycins and derivatives. Furthermore, a truncated analog, SB640, was discovered that retained much of the natural product potency. Detailed studies of the iron chelator anachelin led to the development of a bio-inspired platform for the generation  of bioactive interfaces. The discovery of natural products isolated from cyanobacteria such as nostocarboline, aerucyclamides, cyanopetolin 1020 and various microcystins is presented and their molecular mechanisms of action were investigated. The last part describes the synthesis and evaluation  of various natural products involved in neuritogenesis and synapse reconstruction such as withanolide A, militarinone, farinosone A and C and torrubiellone C. Their potential with regard to their use in regenerative medicine is discussed.
authors.affiliation: University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel, Switzerland. karl.gademann@unibas.ch
authors.forename: Karl
authors.initials: K
authors.lastname: Gademann
authors.forename: Simon
authors.initials: S
authors.lastname: Sieber
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry; D021381:Protein Transport; D011806:Quinolinium Compounds / Q000737:chemistry; D044968:Regenerative Medicine; D017262:Siderophores / Q000737:chemistry
chemical_list: D001688:Biological Products; D011806:Quinolinium Compounds; D017262:Siderophores; C420972:anachelin