title: Current incidence and residual risk of HIV, HBV and HCV at Canadian Blood Services.
abstract: Estimates of the viral residual risk should be updated to reflect current incidence of infection in blood donors. Incidence rates were estimated for allogeneic whole-blood donations made to Canadian Blood Services from 2006 to 2009 based on transmissible disease conversions of repeat donations within a 3-year period. Residual risk was estimated as the incidence multiplied by the window period. The residual risk of HIV was 1 per 8 million donations, HCV 1 per 6·7 million donations and HBV 1 per 1·7 million donations. The residual risk remains low and has decreased for HCV since our previous estimates due to reduced incidence.
authors.affiliation: Department of Epidemiology & Community Medicine, University of Ottawa, Ontario, Canada. sheila.o’brien@blood.ca
authors.forename: S F
authors.initials: SF
authors.lastname: O'Brien
authors.forename: Q-L
authors.initials: QL
authors.lastname: Yi
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: V
authors.initials: V
authors.lastname: Scalia
authors.forename: M A
authors.initials: MA
authors.lastname: Fearon
authors.forename: J-P
authors.initials: JP
authors.lastname: Allain
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D002170:Canada / Q000453:epidemiology; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D015497:HIV-1 / Q000302:isolation & purification; D015498:HIV-2 / Q000302:isolation & purification; D016174:Hepacivirus / Q000302:isolation & purification; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006515:Hepatitis B virus / Q000302:isolation & purification; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D065227:Transfusion Reaction