title: Relationship between body composition, inflammation and lung function in overweight and obese asthma.
abstract: BACKGROUND
  The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma.
  
  
  METHODS
  Overweight and obese (BMI 28-40 kg/m(2)) adults with asthma (n = 44) completed lung function assessment and underwent full-body dual energy x-ray absorptiometry. Venous blood samples and induced sputum were analysed for inflammatory markers.
  
  
  RESULTS
  In females, android and thoracic fat tissue and total body lean tissue were inversely correlated with expiratory reserve volume (ERV). Conversely in males, fat tissue was not correlated with lung function, however there was a positive association between android and thoracic lean tissue and ERV. Lower body (gynoid and leg) lean tissue was positively associated with sputum %neutrophils in females, while leptin was positively associated with android and thoracic fat tissue in males.
  
  
  CONCLUSIONS
  This study suggests that both body composition and inflammation independently affect lung function, with distinct differences between males and females. Lean tissue exacerbates the obese-asthma phenotype in females and the mechanism responsible for this finding warrants further investigation.
authors.affiliation: Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia.
authors.forename: Hayley A
authors.initials: HA
authors.lastname: Scott
authors.forename: Peter G
authors.initials: PG
authors.lastname: Gibson
authors.forename: Manohar L
authors.initials: ML
authors.lastname: Garg
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Pretto
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Morgan
authors.forename: Robin
authors.initials: R
authors.lastname: Callister
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Wood
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000503:physiopathology*; D001823:Body Composition / Q000502:physiology*; D015897:Comorbidity; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D010641:Phenotype; D012129:Respiratory Function Tests; D012727:Sex Characteristics