title: [Glycobiology and neurological disorders].
abstract: Many researchers now recognize the importance of glycobiological research achievements. Glycoside-containing substances such as proteins (glycoproteins) and lipids (glycosphingolipids) have been involved in many important and essential events for normal life. The production of glycoside residues of the proteins is only partially regulated by the genes. In this talk, I will make a brief description of what glycobiology can influence the future of neurological research arena and how glycoproteins and glycolipids affect the normal biology of the neurons. Furthermore, I will introduce you some evidences that many neurological disorders such as Alzheimer's disease and immune-mediated encephalitis have special relationships with glycobiological abnormalities. I also explain the structures and functions of lipid rafts, caveolae, and glycosynapse and their roles in the intracellular signal transduction and cell motility.
authors.affiliation: Department of Neurology, Fujita Health Unviersity School of Medicine.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mutoh
mesh_terms: D006017:Glycolipids / Q000502:physiology; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D009422:Nervous System Diseases / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D006017:Glycolipids; D017475:Receptors, Nerve Growth Factor