title: Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats.
abstract: Stress during pregnancy is known to have a significant impact on animal's behavior and offspring development. The effects of gestational hypoxia on maternal behavior have not been studied. In the present study, we investigated the effects of gestational hypoxia exposure on dam's maternal behavior, offspring's growth and plasma corticosterone levels after parturition in rats. Altitude hypoxia (3 and 5 km) was simulated in the hypobaric chambers during the last week of pregnancy and the effects were compared to those found in controls exposed at sea level. We found that gestational hypoxia significantly decreased dam's arched-back nursing activity across the lactation period. The effect was more profound in 5 km group. Gestational hypoxia also altered other maternal behaviors such as blanket and passive nursing. Hypoxia exposure was associated with abnormal birth weight and postnatal growth in pups, with a significantly higher and lower birth weight than control found in 3 and 5 km groups, respectively, and accelerated growth in both stressed groups. Gestational hypoxia exposure significantly elevated plasma corticosterone levels in dams at the time of weaning and in pups across the measurement days. Taken together, the present results indicate that hypoxia, particularly severe hypoxia during the late phase of pregnancy has a significantly adverse impact on animal's behavior, endocrine function and offspring development. The higher birth weight found in the offspring of 3 km group suggests a compensatory system counteracting with the inhibitory effects of hypoxia on fetus growth at this altitude.
authors.affiliation: College of Life and Environmental Sciences, Hangzhou Normal University, 16 Xuelin Street, Xiasha High Education Area, Hangzhou 310036, Zhejiang, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Shouyang
authors.initials: S
authors.lastname: Du
authors.forename: Jianghui
authors.initials: J
authors.lastname: Bian
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: You
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000302:Adrenal Cortex / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001724:Birth Weight / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D005260:Female; D006120:Grooming; D006128:Growth / Q000502:physiology*; D000860:Hypoxia / Q000473:pathology*; D007774:Lactation / Q000502:physiology*; D008425:Maternal Behavior / Q000502:physiology*; D009425:Nesting Behavior; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016019:Survival Analysis
chemical_list: D003345:Corticosterone