title: Glomeruloid hemangioma in POEMS syndrome: a report on two cases and a review of the literature.
abstract: Glomeruloid hemangioma is characterized by coiled capillary vessels contained within enlarged vascular spaces displaying an architecture that resembles renal glomeruli. The condition is strongly associated with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes). The present paper reports on two cases of glomeruloid hemangiomas associated with POEMS syndrome, and includes a review of the literature. Case one refers to a 63-year old female patient admitted to hospital with ascites, hepatosplenomegaly, walking difficulties and cutaneous hemangiomas. Histopathology revealed a diagnosis of glomeruloid hemangioma and served to guide the clinical work-up, which revealed sensorimotor polyneuropathy, a plasmacytoma in the L4 vertebra with tumor cells positive for kappa chain, and diabetes mellitus. These findings permitted a diagnosis of POEMS syndrome to be reached. The second case consisted of a 39-year old woman admitted to hospital with edema, ascites, pleural effusion, glomeruloid hemangiomas and lymphadenopathy (Castleman's disease). Additional findings included monoclonal IgG-lambda paraproteinemia, blastic lesions in the right iliac bone and L4 vertebra, and demyelinating sensorimotor neuropathy affecting all four limbs. The final diagnosis in this case was POEMS syndrome associated with Castleman's disease.
authors.affiliation: Dermatopathology Department, Dermatology Unit, Hospital Federal de Bonsucesso, Brazil. thiago.jeunon@gmail.com
authors.forename: Thiago
authors.initials: T
authors.lastname: Jeunon
authors.forename: Ana Luisa Bittencourt
authors.initials: AL
authors.lastname: Sampaio
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Caminha
authors.forename: Carlos Umberto da Cunha
authors.initials: CU
authors.lastname: Reis
authors.forename: Cassio
authors.initials: C
authors.lastname: Dib
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000473:pathology; D005260:Female; D006391:Hemangioma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*