title: Effect of intraperitoneal administration of bacterial lipopolysaccharide on synthesis of pro-opiomelanocortin mRNA in rat tanycytes.
abstract: Intensity of pro-opiomelanocortin mRNA synthesis in tanycytes of adrenalectomied and sham-operated rats was studied by in situ hybridization 4 h after intraperitoneal injection of bacterial LPS. The results were compared with pro-opiomelanocortin mRNA expression in rats subjected to immobilization stress. Immobilization and LPS injection to adrenalectomied and sham-operated animals sharply reduced pro-opiomelanocortin mRNA expression in tanycytes. Injection of LPS to sham-operated animals and immobilization stress caused a significant increase in blood corticosterone level. On the other hand, LPS injection did not change low blood level of corticosterone in adrenalectomied rats. The data indicate a synergic inhibitory effect of glucocorticoids and LPS on synthetic activity of tanycytes.
authors.affiliation: Department of Immunology and Cell Biology, Udmurt State University, Izhevsk, Russia. cellbio@ya.ru
authors.forename: V G
authors.initials: VG
authors.lastname: Sergeyev
authors.forename: O A
authors.initials: OA
authors.lastname: Vegeyeva
authors.forename: I G
authors.initials: IG
authors.lastname: Akmayev
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002552:Cerebral Ventricles / Q000166:cytology*; D003345:Corticosterone / Q000097:blood*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011333:Pro-Opiomelanocortin / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D013315:Stress, Psychological
chemical_list: D008070:Lipopolysaccharides; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; D003345:Corticosterone