title: MTHFR polymorphisms and breast cancer risk.
abstract: BACKGROUND
  Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumour cells.
  
  
  METHODS
  We evaluated these two common polymorphisms and breast cancer risk association in an Iranian sporadic breast cancer population-based case-control study of 294 breast cancer cases and 306 controls using a PCR-RFLP-based assay.
  
  
  RESULTS
  Analyses of affected and controls show that homozygote genotype MTHFR 677CC has the highest frequency in both groups (28.3% in patients and 25.3% in control group). Genotype MTHFR 677CT and genotype MTHFR 1298AC were found to be statistically significant risk factors in our population (odds ratio: 1.6, 95% CI: 1.019-2.513, p = 0.041; and odds ratio: 2.575, 95% CI: 1.590-4.158, p = 0.001 respectively).
  
  
  CONCLUSIONS
  We can conclude based on the results of our study that a significant association between breast cancer and C677T and A1298C polymorphism might exist.
authors.affiliation: Department of Science, Islamshahr Branch, Islamic Azad University, Islamshahr, Tehran, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Hosseini
authors.forename: Massoud
authors.initials: M
authors.lastname: Houshmand
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ebrahimi