title: An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses.
abstract: Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that all NW hemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers.
authors.affiliation: Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Helguera
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jemielity
authors.forename: Jonathan
authors.initials: J
authors.lastname: Abraham
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Cordo
authors.forename: M Guadalupe
authors.initials: MG
authors.lastname: Martinez
authors.forename: José A
authors.initials: JA
authors.lastname: Rodríguez
authors.forename: Carlos
authors.initials: C
authors.lastname: Bregni
authors.forename: Jinyize J
authors.initials: JJ
authors.lastname: Wang
authors.forename: Michael
authors.initials: M
authors.lastname: Farzan
authors.forename: Manuel L
authors.initials: ML
authors.lastname: Penichet
authors.forename: Nélida A
authors.initials: NA
authors.lastname: Candurra
authors.forename: Hyeryun
authors.initials: H
authors.lastname: Choe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D015703:Antigens, CD / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D006477:Arenaviruses, New World / Q000502:physiology*; D002460:Cell Line; D015536:Down-Regulation; D006482:Hemorrhagic Fevers, Viral / Q000235:genetics / Q000276:immunology / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011990:Receptors, Transferrin / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D011991:Receptors, Virus / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D053586:Virus Internalization
chemical_list: D000906:Antibodies; D015703:Antigens, CD; C068126:CD71 antigen; D011990:Receptors, Transferrin; D011991:Receptors, Virus