title: Immune modulation of rheumatoid arthritis.
abstract: The approval - several years ago - of the first tumour necrosis factor-α (TNF-α) inhibitor for the management of rheumatoid arthritis launched a new era in the therapeutics of rheumatology. Since then an almost cataclysmic discovery of new treatment targets and corresponding biologic agents ensued. Nowadays, the rheumatologist and the rheumatologic patient have the luxury of several immune modulators available to successfully treat the majority of patients with RA or other inflammatory arthritides and conditions. In this review we focus on a discussion of the approved immune modulators/biologic agents available for the treatment of rheumatoid arthritis. We also present an overview of agents under development. For the immune modulators discussed, we describe their mechanism of action and summarise initial data and recent updates on efficacy and safety.
authors.affiliation: Columbia University of Physicians and Surgeons, Division of Rheumatology, New York, NY 10032, USA.
authors.forename: Dimitrios A
authors.initials: DA
authors.lastname: Pappas
authors.forename: Laura
authors.initials: L
authors.lastname: Geraldino-Pardilla
authors.forename: Joan M
authors.initials: JM
authors.lastname: Bathon
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D017277:Drug Approval; D055808:Drug Discovery; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007155:Immunologic Factors