title: A pilot study examining associations between DYRK1A and α-synuclein dementias.
abstract: BACKGROUND
  DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including α-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions.
  
  
  OBJECTIVE
  To determine if DYRK1A also has a genetic association with α-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia.
  
  
  METHODS
  DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism.
  
  
  RESULTS
  The rs8126696 polymorphism altered the risk of developing an α-synuclein-associated dementia.
  
  
  CONCLUSIONS
  DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia.
authors.affiliation: Wolfson Centre for Age-Related Disease, King's College London, Guy's Campus, London, UK. emma.3.jones@kcl.ac.uk
authors.forename: Emma L
authors.initials: EL
authors.lastname: Jones
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
authors.forename: Elisabet
authors.initials: E
authors.lastname: Londos
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D020961:Lewy Body Disease / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D000097603:Dyrk Kinases
chemical_list: D007381:Intermediate Filament Proteins; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases; C430456:desmuslin