title: Effect of physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach toward understanding high-shear wet granulation process, part 3: effect of binder rheological properties.
abstract: Ternary blends consisting of efavirenz (a model drug compound), lactose monohydrate, and a polymeric binder were investigated to verify the "physical state theory" in which granulation occurs only when binders undergo transition from glassy state to rubbery solution state. Furthermore, it was found that the rheological properties of the binders can significantly affect the granulation process. The blends with binders of viscous flow [polyvinylpyrrolidone (PVP) K17, PVP K25, and PVP K29/32 after exposure to 96% RH] showed an increase in particle size with both binder concentration and mixing time. On the contrary, binders with viscoelastic properties, such as hydroxypropylcellulose (HPC) EXF and PVP K90, did not flow well and thereby, the blends with HPC and PVP K90 did not show much effect of binder concentration and mixing time on their granule size. Moreover, the friability of granules made with HPC EXF and PVP K90 is low, indicating that the strength of the granules largely depends on the viscosity of the binders, as the binders of higher viscosity tend to produce stronger granules. Finally, the viscoelastic state of the polymeric binders upon absorbing water was analyzed using the glass-rubber transition model, which shows five regions with different viscoelastic properties.
authors.affiliation: Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903-0191, USA. jinjiang.li@bms.com
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Tao
authors.forename: David
authors.initials: D
authors.lastname: Buckley
authors.forename: Jing
authors.initials: J
authors.lastname: Tao
authors.forename: Julia
authors.initials: J
authors.lastname: Gao
authors.forename: Mario
authors.initials: M
authors.lastname: Hubert
mesh_terms: D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004339:Drug Compounding; D010316:Particle Size; D012212:Rheology; D013678:Technology, Pharmaceutical
chemical_list: D002482:Cellulose; C008079:hydroxypropylcellulose