title: Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome women.
abstract: OBJECTIVE
  To evaluate in a cross-sectional study adiponectin and leptin levels in prepubertal and pubertal daughters of women with PCOS and their relationship to insulin sensitivity and reproductive features.
  
  
  METHODS
  We studied 92 daughters of PCOS women (PCOSd) and 76 daughters of control women (Cd) matched by age and body mass index SD scores and distributed according to breast Tanner stage: prepuberty (Tanner 1), early puberty (Tanner 2-3) or late puberty (Tanner 4-5). In all girls an oral glucose tolerance test was performed. Leptin, adiponectin, sex steroids, SHBG, glucose, insulin and lipid profile were determined. Leptin-adiponectin ratio, free androgen index and insulin sensitivity (HOMA-IR and ISI composite) were then calculated.
  
  
  RESULTS
  Prepubertal PCOSd showed lower serum adiponectin compared to Cd (p=0.028), whereas during puberty no differences were observed between the groups. Leptin concentrations were similar in both groups in all Tanner stages. In addition, in PCOSd during early puberty, adiponectin showed a negative correlation with testosterone and leptin showed a negative correlation with ISI composite, which were independent of BMI SDS (r=-0.39; p=0.02 and r=-0.42; p=0.01).
  
  
  CONCLUSIONS
  These observations suggest that during the prepubertal period PCOSd exhibit abnormal adiponectin levels, independently of BMI. Moreover, leptin and adiponectin may be related to metabolic and reproductive abnormalities observed in PCOSd during the early stages of sexual development.
authors.affiliation: Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.
authors.forename: Manuel
authors.initials: M
authors.lastname: Maliqueo
authors.forename: José E
authors.initials: JE
authors.lastname: Galgani
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Bravo
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: Amanda Ladrón
authors.initials: AL
authors.lastname: de Guevara
authors.forename: Nicolás
authors.initials: N
authors.lastname: Crisosto
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D009679:Nuclear Family; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011627:Puberty / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D012738:Sex Hormone-Binding Globulin