title: The origin and fate of muscle satellite cells.
abstract: Satellite cells represent the primary population of stem cells resident in skeletal muscle. These adult muscle stem cells facilitate the postnatal growth, remodeling, and regeneration of skeletal muscle. Given the remarkable regenerative potential of satellite cells, there is great promise for treatment of muscle pathologies such as the muscular dystrophies with this cell population. Various protocols have been developed which allow for isolation, enrichment, and expansion of satellite cell derived muscle stem cells. However, isolated satellite cells have yet to translate into effective modalities for therapeutic intervention. Broadening our understanding of satellite cells and their niche requirements should improve our in vivo and ex vivo manipulation of these cells to expedite their use for regeneration of diseased muscle. This review explores the fates of satellite cells as determined by their molecular signatures, ontogeny, and niche dependent programming.
authors.affiliation: Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Rd, Mailbox 511, Ottawa, ON, Canada K1H 8L6.
authors.forename: Arif
authors.initials: A
authors.lastname: Aziz
authors.forename: Soji
authors.initials: S
authors.lastname: Sebastian
authors.forename: F Jeffrey
authors.initials: FJ
authors.lastname: Dilworth
mesh_terms: D019521:Body Patterning; D019070:Cell Lineage; D006801:Humans; D044968:Regenerative Medicine; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction; D055153:Stem Cell Niche