title: Supplementation with L-arginine does not influence arterial blood pressure in healthy people: a randomized, double blind, trial.
abstract: OBJECTIVE
  It cannot be excluded that supplementation with L-arginine, by improving function of endothelium and hypotensive effect, can be advantegeous in prevention of cardiovascular diseases in healthy people. However, reports about hypotensive effect of L-arginine in healthy people are unclear. Moreover, no research including ambulatory blood pressure measurement (ABPM) has been conducted so far. Therefore, the aim of our study was to show if 4-week supplementation of healthy people with L-arginine influences blood pressure measured with ABPM.
  
  
  METHODS
  The study was carried out on 19 healthy people randomized to 6 g/24-hour, 12 g/24-hours of L-arginine or placebo. ABPM was carried out 4 times: before randomization, after 2 and 4 weeks of supplementation and 2 weeks after finishing supplementation.
  
  
  RESULTS
  It was found that 4 weeks of supplementation of healthy people with L-arginine (6 or 12 g/24-hour) led to nonsignificant decrease of systolic and diastolic blood pressure; the decrease was greater during night.
  
  
  CONCLUSIONS
  These findings showed that supplementation with L-arginine is not necessarily advantageous in healthy people.
authors.affiliation: Department of Clinical Pharmacology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Ast
authors.forename: A R
authors.initials: AR
authors.lastname: Cieślewicz
authors.forename: K
authors.initials: K
authors.lastname: Korzeniowska
authors.forename: P
authors.initials: P
authors.lastname: Bogdański
authors.forename: E
authors.initials: E
authors.lastname: Kazmierczak
authors.forename: J
authors.initials: J
authors.lastname: Olszewski
authors.forename: A
authors.initials: A
authors.lastname: Skołuda
authors.forename: A
authors.initials: A
authors.lastname: Jabłecka
mesh_terms: D000328:Adult; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D001120:Arginine