title: Age-related features of expression of cell renewal factors in the intestinal Peyer's patches.
abstract: Immunohistochemical study with markers of proapoptotic protein P53 and proliferation protein Ki-67 revealed an age-related decrease in proliferative activity of lymphocyte in the intestinal Peyer's patches and an increase in the ratio of apoptotic cells in humans. These changes aggravate atrophy and involution of the intestinal epithelium during aging.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Grabezhev
authors.forename: N N
authors.initials: NN
authors.lastname: Sevostjanova
authors.forename: A N
authors.initials: AN
authors.lastname: Kolmakov
authors.forename: S S
authors.initials: SS
authors.lastname: Konovalov
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
mesh_terms: D000375:Aging; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D007422:Intestines / Q000166:cytology; D019394:Ki-67 Antigen / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D010581:Peyer's Patches / Q000166:cytology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53