title: [Focus on granulocyte colony-stimulating factor-induced pulmonary toxicity].
abstract: Granulocyte colony-stimulating factor (G-CSF) are frequently used in oncology and haematology practice. Respiratory disturbance has been reported during administration of G-CSF. G-CSF may induce pulmonary toxicity but this fact remains an open debate because of its frequent association with other drugs. The action of these treatments could explain a part of the pulmonary events but not completely. The specific pulmonary effect of the G-CSF is probably underestimated. Most of these pulmonary events occur in association with other risk factors, mainly when a pneumonia occurs during the neutropenia. However, G-CSF are recommended in febrile neutropenia.
authors.affiliation: CHU de Brest, hôpital Morvan, service d'oncologie thoracique, 5, avenue Foch, 29200 Brest, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Noël-Savina
authors.forename: Renaud
authors.initials: R
authors.lastname: Descourt
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000139:chemically induced*; D009503:Neutropenia / Q000628:therapy; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor