title: [Study of population pharmacokinetic model and parameter analyses for multiple components in Chinese matria medica formula].
abstract: OBJECTIVE
  To eluciate and establish a new population pharmacokinetic mathematical models and parameter calculation for the multiple components in the Chinese Matria Medica Formula (CMMF) through analyses of population pharmacokinetic parameter calculation for single compounds.
  
  
  METHODS
  The model was been set up by statistic moment principle to form a new population pharmacokinetics for the mutiple components in CMMF according to the single compound population pharmacokinetic parameter calculation principle.
  
  
  RESULTS
  It have been established the mathematical model for the population pharmacokinetic model for CMMF that consisted of a series of parameters: 1) total quantum zero moment as AUC(T), 2) first moment as MRT(T), mean residence time of metabolism, 3) second moment as VRT(T), variance of mean residence time of metabolism, 4) total body clearance CL(T), 5) total apparent volum V(T), 6) 95% of total ingredient metabolic time interval PI(T)(0.95), 7) 95% of total ingredient accumulation metabolic time interval Pa(T)(0.95) etc that were correlated with single population pharmacokinetic parameters.
  
  
  CONCLUSIONS
  The population pharmacokinetic model and parameter calculation for CMMF can be established on the bases of single compound population pharmacokinetics by way of total quantum statistic moment principle to be expansived taylor expression at point of population parameter typical values to divide population pharmacokinetic total quantum statistical moment parameters into the four term of typical value, fixed effect, biologic variation and experiment error.
authors.affiliation: Department of Pharmaceutics, Hunan University of Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
authors.forename: Fuyuan
authors.initials: F
authors.lastname: He
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Deng
authors.forename: Wenglong
authors.initials: W
authors.lastname: Liu
authors.forename: Jilian
authors.initials: J
authors.lastname: Shi
authors.forename: Yantao
authors.initials: Y
authors.lastname: Yang
mesh_terms: D006801:Humans; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D010599:Pharmacokinetics