title: Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy.
abstract: OBJECTIVE
  To study hospitalization for psychiatric disorders before and after onset of unprovoked epileptic seizures/epilepsy.
  
  
  METHODS
  In this population-based case-control study, the cases were 1,885 persons from Stockholm with new onset of unprovoked seizures from September 1, 2000, through August 31, 2008, identified in the Stockholm Epilepsy Register. Controls, in total 15,080, were randomly selected from the register of the Stockholm County population. Odds ratios (ORs) were calculated to assess the risk of developing unprovoked epileptic seizures before and after hospitalization for a psychiatric diagnosis defined as a psychiatric hospital discharge diagnosis using International Classification of Disease codes from the Swedish Hospital Discharge Registry.
  
  
  RESULTS
  The age-adjusted OR (95% confidence interval) for unprovoked seizures was 2.5 (1.7-3.7) after a hospital discharge diagnosis for depression, 2.7 (1.4-5.3) for bipolar disorder, 2.3 (1.5-3.5) for psychosis, 2.7 (1.6-4.8) for anxiety disorders, and 2.6 (1.7-4.1) for suicide attempts. The risk of developing unprovoked epileptic seizures was highest less than 2 years before and up to 2 years after a first psychiatric diagnosis.
  
  
  CONCLUSIONS
  The increased rate of psychiatric comorbidity predating and succeeding seizure onset indicates a bidirectional relationship and common underlying mechanisms for psychiatric disorders and epilepsy.
authors.affiliation: Department of Clinical Neurosciences, Karolinska Institutet, Stockholm,Sweden. cecilia.adelow@karolinska.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Adelöw
authors.forename: Tomas
authors.initials: T
authors.lastname: Andersson
authors.forename: Anders
authors.initials: A
authors.lastname: Ahlbom
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Tomson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D012042:Registries; D013548:Sweden / Q000453:epidemiology