title: Noncirrhotic portal hypertension associated with didanosine: a case report and literature review.
abstract: Noncirrhotic portal hypertension (NCPH) has recently been reported as a liver  complication in human immunodeficiency virus (HIV)-infected patients and has been found to be  associated with exposure to didanosine. Here, we describe the case of an HIV-infected patient with  portal hypertension who initially presented with massive ascites and portal vein thrombosis. The  patient's HIV-1 infection was well-controlled with highly active antiretroviral therapy  (lamivudine/didanosine plus nevirapine) for 3 years since its diagnosis in 2007. He had no history  of alcoholism, drug abuse, or liver diseases. An extensive work-up for other possible causes of  liver disease was performed, but the results were inconclusive. In addition to reporting this case,  we have reviewed the literature on didanosine-related NCPH and analyzed the findings of 61 similar  previously reported cases.
authors.affiliation: Department of Pharmacy, Kaohsiung Veterans General Hospital, 386 Ta-Chung First Rd., Kaohsiung, Taiwan.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Chang
authors.forename: Hung-Chin
authors.initials: HC
authors.lastname: Tsai
authors.forename: Susan Shin-Jung
authors.initials: SS
authors.lastname: Lee
authors.forename: Shue-Ren
authors.initials: SR
authors.lastname: Wann
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
mesh_terms: D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D001201:Ascites / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D016049:Didanosine / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000473:pathology; D019259:Lamivudine / Q000008:administration & dosage; D008297:Male; D019829:Nevirapine / Q000008:administration & dosage; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000473:pathology; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019259:Lamivudine; D019829:Nevirapine; D016049:Didanosine