title: Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats.
abstract: Childhood obesity is becoming more prevalent; however, the influence of obesity or dieting during childhood on outcomes in adulthood is poorly understood. The aim of this study was to examine the effects of short-term calorie restriction (CR) and high-calorie feeding with high-fat or high-sucrose diets during early life on the development of glucose tolerance and diabetic nephropathy in later life of Otsuka Long-Evans Tokushima fatty (OLETF) rats. Neither high-calorie intake nor CR at 7-13 weeks of age affected glucose tolerance of 27-week-old OLETF rats. On the other hand, proteinuria was lower at 27 weeks of age in CR rats than in the other rats. These results suggest that short-term CR at a young age protects against the development of renal injury in later life. In contrast, short-term high-calorie intake or CR at a young age does not appear to affect glucose metabolism in later life.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakano
authors.forename: Suwarni
authors.initials: S
authors.lastname: Diah
authors.forename: Kento
authors.initials: K
authors.lastname: Kitada
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hitomi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Mori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobori
authors.forename: Akira
authors.initials: A
authors.lastname: Nishiyama