title: Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats.
abstract: Reproductive functions are controlled by a finely tuned balance between estrogens and androgens. To further characterize the gonadal pathways leading to hormonal balance disruption by atrazine, vinclozolin, methoxychlor, and bisphenol A in rat, we investigated their effects in male and female young adult animals. Specifically, we assessed reproductive tract alterations, sex hormone balance in serum and gonads, tissue dosimetry, and mRNA expression. Remarkably, we observed different aromatase regulation profiles between animals with similar estrogen-to-androgen ratios but with different chemical treatments. For example, increased estrogen-to-androgen ratios in atrazine-treated females could be partly linked to aromatase upregulation, while in methoxychlor- and bisphenol A-treated females, peripheral mechanisms such as conjugation/deconjugation processes might be more likely to elevate estrogen levels. In vinclozolin-treated animals, the decreased estrogen-to-androgen ratios reported might be due to an increase of peripheral (adrenal) steroidogenesis. Thus, measurement of many endpoints is necessary for good risk assessment.
authors.affiliation: Experimental Toxicology Unit, INERIS, Parc Technologique ALATA, 60550 Verneuil-en-Halatte, France. nadia.quignot@gmail.com
authors.forename: Nadia
authors.initials: N
authors.lastname: Quignot
authors.forename: Marine
authors.initials: M
authors.lastname: Arnaud
authors.forename: Franck
authors.initials: F
authors.lastname: Robidel
authors.forename: Anthony
authors.initials: A
authors.lastname: Lecomte
authors.forename: Mikaël
authors.initials: M
authors.lastname: Tournier
authors.forename: Cécile
authors.initials: C
authors.lastname: Cren-Olivé
authors.forename: Robert
authors.initials: R
authors.lastname: Barouki
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lemazurier
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000254:growth & development; D000818:Animals; D001141:Aromatase / Q000235:genetics; D001280:Atrazine / Q000493:pharmacokinetics / Q000633:toxicity*; D001559:Benzhydryl Compounds; D001835:Body Weight / Q000187:drug effects; D052244:Endocrine Disruptors / Q000493:pharmacokinetics / Q000633:toxicity*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D008297:Male; D008731:Methoxychlor / Q000493:pharmacokinetics / Q000633:toxicity*; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D010080:Oxazoles / Q000493:pharmacokinetics / Q000633:toxicity*; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013081:Sperm Motility / Q000187:drug effects; D014599:Uterus / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D000098826:Bisphenol A Compounds
chemical_list: D001141:Aromatase; D001280:Atrazine; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D012739:Gonadal Steroid Hormones; D008731:Methoxychlor; D010080:Oxazoles; D010636:Phenols; D012333:RNA, Messenger; C025643:vinclozolin; C006780:bisphenol A; D000098826:Bisphenol A Compounds