title: A general solution for the 2-pyridyl problem.
abstract: Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA)(2) powerfully enables palladium-mediated cross-couplings with air-stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF=N,N'-dimethylformamide, Tf=trifluoromethanesulfonyl.
authors.affiliation: Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana-Champaign, 61801, USA.
authors.forename: Graham R
authors.initials: GR
authors.lastname: Dick
authors.forename: Eric M
authors.initials: EM
authors.lastname: Woerly
authors.forename: Martin D
authors.initials: MD
authors.lastname: Burke
mesh_terms: D001880:Boranes / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*
chemical_list: D001880:Boranes; D001897:Boronic Acids; D056831:Coordination Complexes; D011725:Pyridines; D012996:Solutions; D010165:Palladium; D003300:Copper; C023666:pyridine