title: The influence of obesity on postoperative inflammatory cytokine levels.
abstract: Obesity is a chronic inflammatory state and adipose tissue serves as a source of inflammatory mediators. This study compared plasma levels of the proinflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in 20 morbidly obese patients (group O) undergoing  laparoscopic Roux-en-Y gastric bypass surgery and in 20 non-obese control patients (group C) undergoing laparascopic gastrectomy. Blood was sampled preoperatively and at 3 and 24 h postoperatively. Postoperative IL-6 levels increased significantly in both groups, but were significantly lower  in group O than in group C. Age- and anaesthetic timeadjusted IL-6 levels showed a significant increase at 24 h postoperatively compared with preoperative values in both groups; changes were significantly greater in group C. TNF-α levels did not change significantly over time, but were  significantly lower in group O at 3 h postoperatively compared with group C. In conclusion, postoperative changes in IL-6 and TNF-α levels in morbidly obese patients were lower than in non-obese patients. Adipose tissue appears not to contribute to the acute postoperative inflammatory  response.
authors.affiliation: Department of Anaesthesia and Pain Medicine, St Paul's Hospital, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.
authors.forename: M-Y
authors.initials: MY
authors.lastname: Chung
authors.forename: S-J
authors.initials: SJ
authors.lastname: Hong
authors.forename: J-Y
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000328:Adult; D003710:Demography; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D011300:Preoperative Care; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha