title: Genetic variations of glutathione s-transferase influence on blood cadmium concentration.
abstract: The glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd). Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility. The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population. The 370 blood samples were analyzed for Cd concentration and polymorphisms in GSTs genes. Geometric mean of blood Cd among this population was 0.46 ± 0.02 μg/L (with 95% CI; 0.43-0.49 μg/L). Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes. No significant differences in blood Cd concentrations among individual with gene deletions of GSTT1 and GSTM1 were observed. GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels. This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.
authors.affiliation: Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Nitchaphat
authors.initials: N
authors.lastname: Khansakorn
authors.forename: Waranya
authors.initials: W
authors.lastname: Wongwit
authors.forename: Prapin
authors.initials: P
authors.lastname: Tharnpoophasiam
authors.forename: Bunlue
authors.initials: B
authors.lastname: Hengprasith
authors.forename: Lerson
authors.initials: L
authors.lastname: Suwannathon
authors.forename: Suwannee
authors.initials: S
authors.lastname: Chanprasertyothin
authors.forename: Thunyachai
authors.initials: T
authors.lastname: Sura
authors.forename: Sming
authors.initials: S
authors.lastname: Kaojarern
authors.forename: Piyamit
authors.initials: P
authors.lastname: Sritara
authors.forename: Jintana
authors.initials: J
authors.lastname: Sirivarasai