title: Antimycobacterial and antioxidant activities of reserpine and its derivatives.
abstract: In view of the attributed medicinal properties of reserpine, a number of acyl reserpine derivatives were prepared and tested for antimycobacterial activity against Mycobacterium tuberculosis, strain H(37)Rv and antioxidant activities. The results indicated that in the case of antimycobacterial activity, 10 out of 18 derivatives caused more inhibition than that caused by reserpine itself. The results of antioxidant activity revealed that acylation in benzene ring of reserpine decreases the percentage inhibition of DPPH in all the derivatives compared to the parent compound.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. sabira@khi.comsats.net.pk
authors.forename: Sabira
authors.initials: S
authors.lastname: Begum
authors.forename: Syeda Qamar Zehra
authors.initials: SQ
authors.lastname: Naqvi
authors.forename: Aqeel
authors.initials: A
authors.lastname: Ahmed
authors.forename: Saima
authors.initials: S
authors.lastname: Tauseef
authors.forename: Bina Shaheen
authors.initials: BS
authors.lastname: Siddiqui
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D012110:Reserpine / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D012110:Reserpine