title: Magnetically targeted drug delivery during cardiopulmonary resuscitation and the post-resuscitation period.
abstract: Treatment with pharmacological agents is frequently required during cardiopulmonary resuscitation efforts and almost always during the post-resuscitation period. However, the lack of scientific evidence, the potent side effects and the association of resuscitation drugs with poor outcome act as a disincentive for their use. The use of magnetic nanoparticles in medicine has great potential. Magnetically targeted drug delivery may be an ideal method of pharmaceutical treatment during the resuscitation efforts and post-resuscitation period. In addition, there is evidence that magnetic nanotechnology may be used in the detection of post-cardiac arrest brain injury. In the light of poor survival of cardiac arrest victims, research in cardiopulmonary resuscitation should focus on this promising technology as soon as possible.
authors.affiliation: National and Kapodistrian University of Athens, Medical School, Department of Anatomy, Athens, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
authors.forename: Michael
authors.initials: M
authors.lastname: Chatzigeorgiou
authors.forename: Elizabeth O
authors.initials: EO
authors.lastname: Johnson
authors.forename: Athanasios
authors.initials: A
authors.lastname: Chalkias
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D058185:Magnetite Nanoparticles
chemical_list: D058185:Magnetite Nanoparticles