title: Long-term outcomes in acute pulmonary thromboembolism: the incidence of chronic thromboembolic pulmonary hypertension and associated risk factors.
abstract: The long-term outcomes of pulmonary thromboembolism (PTE) and/or incidence of chronic thromboembolic pulmonary hypertension (CTEPH) are not well documented. Three hundred twenty-five consecutive cases objectively diagnosed with PTE monitored for an average 16.3 months (6-50.7 months) were investigated. Data concerning recurrence, residual thrombus, mortality, and CTEPH in particular were collected. Chronic thromboembolic pulmonary hypertension frequency acute first episode of PTE was 4.6%. Chronic thromboembolic pulmonary hypertension developed within 12 months after PTE attack in approximately 80% of patients and it did not occur after 2 years. Residual chronic thrombus was determined at the 3rd month in 48% of cases post-PTE, at the 6th month in 27.4%, and at the 12th month in 18.2%. At multivariate regression analysis, systolic pulmonary arterial pressure > 50 mm Hg, hazard ratio: 10.1 (95% confidence interval: 4.1-71.2) were predictors of CTEPH. Chronic thromboembolic pulmonary hypertension develops as a serious complication in a significant number of cases with PTE. Closer monitoring of high-risk cases in particular is important in terms of early diagnosis and treatment.
authors.affiliation: Department of Chest Diseases, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozlu
authors.forename: Savas
authors.initials: S
authors.lastname: Ozsu
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kazaz
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Bulbul
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors