title: Therapeutic potential of Liver Receptor Homolog-1 modulators.
abstract: Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.
authors.affiliation: Prince Henry's Institute, Clayton, Victoria 3168, Australia.
authors.forename: Kyren A
authors.initials: KA
authors.lastname: Lazarus
authors.forename: Dhilushi
authors.initials: D
authors.lastname: Wijayakumara
authors.forename: Ashwini L
authors.initials: AL
authors.lastname: Chand
authors.forename: Evan R
authors.initials: ER
authors.lastname: Simpson
authors.forename: Colin D
authors.initials: CD
authors.lastname: Clyne
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: C082631:NR5A2 protein, human; C431936:Nr5a2 protein, mouse; D010743:Phospholipids; D018160:Receptors, Cytoplasmic and Nuclear; D002784:Cholesterol