title: Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment.
abstract: Head and neck oncologists have traditionally relied on clinical tumor features and patient characteristics to guide care of individual patients. As surgical, radiotherapeutic, and systemic treatments have evolved to become more anatomically precise and mechanistically specific, the opportunity for improved cure and functional patient recovery has never been more promising for this historically debilitating cancer. However, personalized treatment must be accompanied by sophisticated patient selection to triage the application of advanced therapies toward ideal patient candidates. In this monograph, we review current progress, investigative themes, and key challenges facing head and neck cancer biomarker development intended to make personalized head and neck cancer treatment a clinical reality.
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lucs
authors.affiliation: Department of Otolaryngology, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Saltman
authors.affiliation: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Christine H
authors.initials: CH
authors.lastname: Chung
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, NY, USA.|Department of Otolaryngology, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Bettie M
authors.initials: BM
authors.lastname: Steinberg
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, NY, USA.|Department of Otolaryngology, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.|Department of Radiation Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Schwartz
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D057285:Precision Medicine / Q000379:methods*; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor