title: Identification of (-)(E)-N-[2(S)-Hydroxy-2-(4-hydroxyphenyl) ethyl]ferulamide, a natural product isolated from Croton pullei: theoretical and experimental analysis.
abstract: Ferulic acid (FA) and its derivatives (FADs) are known for a variety of biological activities, such as photo-protective agent, antioxidant, antiatherogenic and antiplasmodial activities. During structural definition of a FAD isolated from Croton pullei, the possibility of a heterologous series made this definition difficult. In this regard, computational simulations were performed using theoretical calculations at DFT level to predict Infrared (IR) and Nuclear Magnetic Resonance (NMR) data. The IR and NMR (13)C and (1)H data were compared with the theoretical calculations performed for three structural possibilities of a heterologous series. The theoretical results were compared with the experimental data through linear regression in order to define the most probable structure and showed satisfactory values.
authors.affiliation: Faculty of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, CP 11101, Belém, PA 66075-110, Brazil. silvana.silva@icen.ufpa.br
authors.forename: Silvana de O
authors.initials: Sde O
authors.lastname: Silva
authors.forename: Rosana N S
authors.initials: RN
authors.lastname: Peixoto
authors.forename: José Rogério A
authors.initials: JR
authors.lastname: Silva
authors.forename: Cláudio N
authors.initials: CN
authors.lastname: Alves
authors.forename: Giselle M S P
authors.initials: GM
authors.lastname: Guilhon
authors.forename: Lourivaldo S
authors.initials: LS
authors.lastname: Santos
authors.forename: Davi do S B
authors.initials: Ddo S
authors.lastname: Brasil
mesh_terms: D001688:Biological Products / Q000737:chemistry; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001688:Biological Products; D003373:Coumaric Acids; D010936:Plant Extracts