title: Trends in estimated kidney function: the FINRISK surveys.
abstract: We evaluated the temporary trend in estimated glomerular filtration rate (eGFR) of subjects aged from 25 to 74 years between two cross-sectional population surveys in 2002 and in 2007. The mean eGFR across age-groups, the prevalences of eGFR categories, and the prevalence of chronic kidney disease (CKD) stage 3–5 defined by eGFR\60 mL/min/1.73 m2 were defined in sex- and age-specific groups using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Study equation. The eGFR decreased from year 2002 to 2007 across the age-groups in both genders. The prevalence of CKD stage 3–5 (eGFR\60 mL/min/1.73) increased in women from 1.8 to 3.1% (P=0.017), but not in men. In the combined analysis of both genders, CKD stage 3–5 was markedly more common in 2007 compared to 2002, with odds ratio (OR) 1.59 (95% confidence interval (CI) 1.22–2.08) remaining significant after adjusting the model for age, gender, study area, hypertension, obesity, prior cardiovascular disease, and diabetes mellitus, and being at lowest when only age, gender and waist circumference were included in the model (OR 1.34; 95% CI 1.02–1.76). To conclude, the mean eGFR decreased significantly during 2002–2007 in both sexes, and CKD stage 3–5 increased in women. This trend was concurrent with increases in mean waist circumference and in the prevalence of diabetes mellitus.
authors.affiliation: Institute of Clinical Medicine/Internal Medicine, Universityof Eastern Finland, and Department of Medicine, Kuopio University Hospital, P.O.B. 1777, 70211 Kuopio, Finland. auni.juutilainen@kuh.fi
authors.forename: Auni
authors.initials: A
authors.lastname: Juutilainen
authors.forename: Helena
authors.initials: H
authors.lastname: Kastarinen
authors.forename: Riitta
authors.initials: R
authors.lastname: Antikainen
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Pekka
authors.initials: P
authors.lastname: Jousilahti
authors.forename: Jouko
authors.initials: J
authors.lastname: Sundvall
authors.forename: Tiina
authors.initials: T
authors.lastname: Laatikainen
authors.forename: Mika
authors.initials: M
authors.lastname: Kastarinen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005919:Glomerular Filtration Rate; D006306:Health Surveys / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors; D017678:Sex Distribution