title: Effect of plasma lipids, hypertension and APOE genotype on cognitive decline.
abstract: We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4-) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4- and E4+, and HDL level in E4-. The combination of hypertension and E4+, but not E4-, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline.
authors.affiliation: Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. ejm86rp@yahoo.co.jp
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanimukai
authors.forename: Megumi
authors.initials: M
authors.lastname: Sasaki
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ikejima
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamashita
authors.forename: Chiine
authors.initials: C
authors.lastname: Kodama
authors.forename: Shin
authors.initials: S
authors.lastname: Hidaka
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Mizukami
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
mesh_terms: D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001057:Apolipoproteins E; D008055:Lipids