title: Monocrotaline-induced pulmonary hypertension in Wistar rats.
abstract: Pulmonary arterial hypertension (PAH) is a debilitating and often fatal disease characterized by a progressive increase in pulmonary vascular resistance that leads to right ventricular failure. Described in this unit is an in vivo model of monocrotaline-induced pulmonary hypertension in rats that can be used to assess the effects of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy.
authors.affiliation: Actelion Pharmaceuticals, Allschwil, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Rey
authors.forename: Patrick
authors.initials: P
authors.lastname: Hess
authors.forename: Martine
authors.initials: M
authors.lastname: Clozel
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D002339:Carotid Arteries / Q000601:surgery; D002407:Catheterization, Swan-Ganz; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D017380:Hypertrophy, Right Ventricular / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D016686:Monocrotaline; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000959:Antihypertensive Agents; D016686:Monocrotaline