title: Hypertrophic perianal herpes successfully treated with imiquimod.
abstract: Herpes simplex virus type 2 (HSV-2) infections are frequent in HIV (human immunodeficiency virus) infected patients. In those cases, genital herpes may have an atypical clinical presentation. Hypertrophic and vegetating variants are unusual. The authors describe a case of hypertrophic perianal herpes in an HIV patient with unsatisfactory response to acyclovir and valacyclovir, successfully treated with imiquimod. Hypertrophic genital herpes cases are frequently refractory to antiviral treatments. In our experience, imiquimod is an efficient, safe and well tolerated treatment that should be considered in therapeutic approach of these patients.
authors.affiliation: Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Portugal. saralestre@gmail.com
authors.forename: Sara Isabel Alcântara
authors.initials: SI
authors.lastname: Lestre
authors.forename: Alexandre
authors.initials: A
authors.lastname: João
authors.forename: Célia
authors.initials: C
authors.lastname: Carvalho
authors.forename: Vasco Vieira
authors.initials: VV
authors.lastname: Serrão
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000634:Aminoquinolines / Q000627:therapeutic use*; D001003:Anal Canal / Q000821:virology; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications; D015497:HIV-1; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D000077271:Imiquimod; D008875:Middle Aged
chemical_list: D000634:Aminoquinolines; D000998:Antiviral Agents; D000077271:Imiquimod; D000212:Acyclovir