title: [Experimental study of candidate vaccines against variable or quasi-species pathogenes: multiepitopic synthetic peptide antigenes and new receptor-guiding adjuvants].
abstract: The short multiepitopic synthetic peptides from the sequences of hypervariable area of V3-loope of gp120 of HIV don't induce anti-peptides antibodies production in mice themselves. We prepared the potent immunogen by noncovalent conjugations of the multitude peptides with pure peptidoglycans from cell wall of Salmonella typhi. The sera from immunized mice have the anti-peptides antibody titers (3-5) x 10(5) in ELISA, as high as Freund's adjuvant is of use.
authors.forename: G A
authors.initials: GA
authors.lastname: Ignat'eva
authors.forename: A Z
authors.initials: AZ
authors.lastname: Maksiutov
authors.forename: V L
authors.initials: VL
authors.lastname: L'vov
authors.forename: A A
authors.initials: AA
authors.lastname: Kolobov
authors.forename: T I
authors.initials: TI
authors.lastname: Ignat'ev
mesh_terms: D016915:AIDS Vaccines / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D010455:Peptides; D010457:Peptidoglycan / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D012485:Salmonella typhi / Q000737:chemistry* / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D015699:HIV Envelope Protein gp120; D010455:Peptides; D010457:Peptidoglycan