title: Thrombosis and acute coronary syndrome.
abstract: Acute coronary syndromes (ACS) represent the main clinical manifestation of atherosclerotic progression in the coronary district. Thrombosis plays a critical role in the patho-anatomical of ACS, as disruption of an atherosclerotic plaque exposes flowing blood to subendothelial collagen, tissue factor, and other procoagulant molecules that trigger activation of platelets and formation of fibrin within the vessel lumen. Endothelial damage/dysfunction, inflammation and coagulation are closely related to the pathophysiology of ACS and may be inter-related. Platelets play key roles in both the formation of the atheromatous plaque and clinical presentation of acute atherothrombotic events following plaque rupture. In the pathogenesis of the ACS, blood clotting activation has a crucial role and thrombin generation and TF may represent useful markers for the identification of patients at high risk of vascular events. Lipoprotein-associated phospholipase A2 (Lp-PLA2) represents the crossroads between lipid metabolism and inflammatory response.
authors.affiliation: Department of Medical and Surgical Critical Care, University of Florence - SOD Atherothrombotic Diseases, AOU Careggi, Florence, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Abbate
authors.forename: Gabriele
authors.initials: G
authors.lastname: Cioni
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ricci
authors.forename: Marco
authors.initials: M
authors.lastname: Miranda
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Gori
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D003328:Coronary Thrombosis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005342:Fibrinolysis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D015539:Platelet Activation