title: Evidence of a non-motor microlesion effect following deep brain surgery: a case report.
abstract: We report the case of a patient who developed acute transient psychosis after implantation, but not activation of pallidal deep brain electrodes for generalised dystonia. Psychotic symptoms coincided temporally with postoperative motor improvement induced by the microlesion effect after electode implantation. This finding suggests that the microlesion effect may not be confined to motor improvement, but also comprises non-motor symptoms. In our case, affection of adjacent dopaminergic fibres of passages has to be assumed.
authors.affiliation: Department of Neurology, Klinikum Grosshadern, University of Munich, München, Germany. verena.rozanski@med.uni-muenchen.de
authors.forename: Verena Eveline
authors.initials: VE
authors.lastname: Rozanski
authors.forename: Martin
authors.initials: M
authors.lastname: Lieb
authors.forename: Christian
authors.initials: C
authors.lastname: Vollmar
authors.forename: Jan-Hinnerk
authors.initials: JH
authors.lastname: Mehrkens
authors.forename: Kai
authors.initials: K
authors.lastname: Bötzel
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D020821:Dystonic Disorders / Q000150:complications / Q000601:surgery*; D004567:Electrodes, Implanted / Q000009:adverse effects*; D005260:Female; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009043:Motor Activity; D011618:Psychotic Disorders / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome