title: Transcriptome-wide network analysis of squamous lung cancer reveals potential methylation genes.
abstract: Lung cancer is a prevalent cancer with a high death rate. Underlying mechanisms have been found to be highly correlated with epigenetics, especially with DNA methylation. With methylation array and other regulation data, we constructed a TF-gene regulation network and a TF-pathway network. Through those networks, we identified lung cancer related genes that were found by previous studies, and supposed a number of new examples. Our work demonstrated the new potential methylation for lung cancer.
authors.affiliation: Department of Laboratory Medicine, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jiatao
authors.initials: J
authors.lastname: Lou
authors.forename: Jian
authors.initials: J
authors.lastname: Xue
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D019175:DNA Methylation; D020869:Gene Expression Profiling / Q000379:methods; D053263:Gene Regulatory Networks; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D059467:Transcriptome
chemical_list: D014157:Transcription Factors