title: Conduction barriers and pathways of the sinoatrial pacemaker complex: their role in normal rhythm and atrial arrhythmias.
abstract: Since Keith and Flack's anatomical discovery of the sinoatrial node (SAN), the primary pacemaker of the heart, the question of how such a small SAN structure can pace the entire heart has remained for a large part unanswered. Recent advances in optical mapping technology have made it possible to unambiguously resolve the origin of excitation and conduction within the animal and human SAN. The combination of high-resolution optical mapping and histological structural analysis reveals that the canine and human SANs are functionally insulated from the surrounding atrial myocardium, except for several critical conduction pathways. Indeed, the SAN as a leading pacemaker requires anatomical (fibrosis, fat, and blood vessels) and/or functional barriers (paucity of connexins) to protect it from the hyperpolarizing influence of the surrounding atrium. The presence of conduction barriers and pathways may help explain how a small cluster of pacemaker cells in the SAN pacemaker complex manages to depolarize different, widely distributed areas of the right atria as evidenced functionally by exit points and breakthroughs. The autonomic nervous system and humoral factors can further regulate conduction through these pathways, affecting pacemaker automaticity and ultimately heart rate. Moreover, the conduction barriers and multiple pathways can form substrates for reentrant activity and thus lead to atrial flutter and fibrillation. This review aims to provide new insight into the function of the SAN pacemaker complex and the interaction between the atrial pacemakers and the surrounding atrial myocardium not only in animal models but also human hearts.
authors.affiliation: Department of Physiology and Cell Biology, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210-1218, USA. vadim.fedorov@osumc.edu
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Fedorov
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Glukhov
authors.forename: Roger
authors.initials: R
authors.lastname: Chang
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D016275:Atrial Function / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology; D004285:Dogs; D006329:Heart Conduction System / Q000502:physiology* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D012849:Sinoatrial Node / Q000502:physiology* / Q000503:physiopathology