title: The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes.
abstract: The capacity of Vibrio cholerae to form biofilms has been shown to enhance its survival in the aquatic environment and play important roles in pathogenesis and disease transmission. In this study, we demonstrated that the histone-like nucleoid structuring protein is a repressor of exopolysaccharide (vps) biosynthesis genes and biofilm formation.
authors.affiliation: Southern Research Institute, Drug Discovery Division, Department of Biochemistry and Molecular Biology, Birmingham, Alabama, USA.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Wang
authors.forename: Julio C
authors.initials: JC
authors.lastname: Ayala
authors.forename: Anisia J
authors.initials: AJ
authors.lastname: Silva
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Benitez
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000494:pharmacology*; D015536:Down-Regulation; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria; D011135:Polysaccharides, Bacterial