title: Frontal infarcts and anxiety in stroke.
abstract: OBJECTIVE
  This study examined the association between poststroke anxiety symptoms (PSA) and frontal lobe infarcts.
  
  
  METHODS
  A cohort of 693 patients was recruited. PSA was defined as an anxiety subscale of the Hospital Anxiety and Depression Scale score of 8 or above. The presence and location of infarcts were evaluated with MRI.
  
  
  RESULTS
  Compared with the non-PSA group, PSA patients were more likely to have right frontal acute infarcts. Right frontal infarcts remained independent predictors of PSA in the multivariate analysis, with an odds ratio of 4.44 (P=0.002).
  
  
  CONCLUSIONS
  The results suggest that right frontal acute infarcts may play a role in the development of PSA.
authors.affiliation: Department of Psychiatry, Shatin Hospital, Hong Kong SAR, China. tangwk@cuhk.edu.hk
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Tang
authors.forename: Yangkun
authors.initials: Y
authors.lastname: Chen
authors.forename: Jinyan
authors.initials: J
authors.lastname: Lu
authors.forename: Huajun
authors.initials: H
authors.lastname: Liang
authors.forename: Winnie Chiu Wing
authors.initials: WC
authors.lastname: Chu
authors.forename: Vincent Chung
authors.initials: VC
authors.lastname: Tong Mok
authors.forename: Gabor Sandor
authors.initials: GS
authors.lastname: Ungvari
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
mesh_terms: D000368:Aged; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology*; D020520:Brain Infarction / Q000150:complications / Q000473:pathology*; D015331:Cohort Studies; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D020521:Stroke / Q000523:psychology*