title: Convergent integration of two self-labor domino sequences: a novel method for the synthesis of oxazole derivatives from methyl ketones and benzoins.
abstract: A highly efficient method for the synthesis of oxazole derivatives from methyl ketones, benzoins and ammonium acetate has been established via a novel strategy-convergent integration of two self-labor domino sequences. Owing to the simple and readily available starting materials, mild reaction conditions, facile operation, and the high bioactivity of oxazole derivatives, this reaction promises diverse applications in medical chemistry. Additionally, this reaction could provide an efficient example for self-labor synthesis strategy of organic compounds.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China.
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Xue
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhu
authors.forename: Jun-Gang
authors.initials: JG
authors.lastname: Wang
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu
mesh_terms: D000085:Acetates / Q000737:chemistry; D001573:Benzoin / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis*
chemical_list: D000085:Acetates; D007659:Ketones; D010080:Oxazoles; D001573:Benzoin; C018824:ammonium acetate; D004121:Dimethyl Sulfoxide