title: [Association of albuminuria with adipokines, inflammation and insulin resistance in non-diabetic subjects].
abstract: The objective of this study was to evaluate the association of traditional cardiovascular risk factors, adipokines, inflammation and insulin resistance with low-grade urinary albumin-to-creatinine ratio (ACR) in nondiabetic, healthy subjects.
  
  
  METHODS
  The study included 117 healthy subjects (64 men and 53 women), who were classified according to their body mass index (BMI) into three groups: lean (BMI<25 kg/m2), overweight (25< or =BMI<30 kg/m2) and obese (BMI> or =30 kg/m2).
  
  
  RESULTS
  ACR was higher in obese men and women compared to overweight and lean men and women (men - 3 mg/g vs. 6.1 mg/g vs. 8.9 mg/g, p=0.018; women - 2.1 mg/g vs. 6.7 mg/g vs. 9.1 mg/g, p=0.03). In univariate analyses ACR was associated in obese men with adiponectin (r=-0.43, p=0.021) and systolic blood pressure (r=0.51, p=0.006) and in non-obese men with systolic blood pressure (r=0.39, p=0.041). In women systolic blood pressure was the only determinant both in obese (r=0.49, p=0.022) and non-obese subjects (r=0.42, p=0.04).
  
  
  CONCLUSIONS
  Adiponectin is an important mediator of low-grade albuminuria in obese, non-diabetic men.
authors.affiliation: Spitalul Clinic Colentina, Bucureşti.
authors.forename: R
authors.initials: R
authors.lastname: Vasilescu
authors.forename: C
authors.initials: C
authors.lastname: Ionescu-Tîrgovişte
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000419:Albuminuria / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D003404:Creatinine / Q000652:urine*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000652:urine; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D050177:Overweight / Q000097:blood / Q000652:urine; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D003404:Creatinine