title: Rapid psychosocial function screening test identified treatment failure in HIV+ African youth.
abstract: Psychosocial dysfunction in older children and adolescents is common and may lead to nonadherence to HIV treatments. Poor adherence leads to HIV treatment failure and the development of resistant virus. In resource-limited settings where treatment options are typically limited to only one or two available lines of therapy, identification of individuals at highest risk of failure before failure occurs is of critical importance. Rapid screening tools for psychosocial dysfunction may allow for identification of those children and adolescents who are most likely to benefit from limited psychosocial support services targeted at preventing HIV treatment failure. The Pediatric Symptom Checklist (PSC) is used in high resource settings for rapid identification of at-risk youth. In 692 HIV-infected treated children (ages of 8-< 17 years) in Botswana, having a high score on the PSC was associated with having virologic failure (OR 1.7, 95% CI: 1.1-2.6). The PSC may be a useful screening tool in pediatric HIV.
authors.affiliation: General Pediatrics, Children's Hospital of Philadelphia, PA, USA. lowenthale@email.chop.edu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Lowenthal
authors.forename: Kathy
authors.initials: K
authors.lastname: Lawler
authors.forename: Nurit
authors.initials: N
authors.lastname: Harari
authors.forename: Lesedi
authors.initials: L
authors.lastname: Moamogwe
authors.forename: Japhter
authors.initials: J
authors.lastname: Masunge
authors.forename: Motshodi
authors.initials: M
authors.lastname: Masedi
authors.forename: Bolefela
authors.initials: B
authors.lastname: Matome
authors.forename: Esther
authors.initials: E
authors.lastname: Seloilwe
authors.forename: Robert
authors.initials: R
authors.lastname: Gross
mesh_terms: D000293:Adolescent; D000342:Affective Symptoms / Q000175:diagnosis* / Q000453:epidemiology; D019380:Anti-HIV Agents; D044383:Black People; D001902:Botswana / Q000453:epidemiology; D057189:Checklist; D002648:Child; D002662:Child Health Services / Q000458:organization & administration*; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D055118:Medication Adherence / Q000523:psychology*; D015995:Prevalence; D011581:Psychological Tests; D012920:Social Behavior Disorders / Q000175:diagnosis* / Q000453:epidemiology; D011795:Surveys and Questionnaires; D017211:Treatment Failure; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents