title: Decreased gonadotropin requirements in once daily compared to twice daily administration: a prospective, randomized study.
abstract: OBJECTIVE
  Despite the lack of any scientific data, many ART programs split the daily gonadotropin dose during ovarian stimulation, while others give the entire dose during a single administration, usually at night.
  
  
  METHODS
  Prospective randomized.
  
  
  METHODS
  213 women undergoing IVF/ICSI cycles at a single private ART center.
  
  
  METHODS
  Gonadotropin administration once daily compared to twice daily.
  
  
  METHODS
  Gonadotropin usage, clinical and ongoing PR                                               RESULTS:                          There were 110 women in the once daily compared to 103 in the twice daily arm. All cycles were blastocyst transfers. There was a significantly lower FSH use in the once daily arm compared to the twice daily arm (1507.5 ± 517.5 IU vs. 1702.5 ± 622.5, P = 0.015), and a trend towards lower hMG use in the once daily arm (1342.5 ± 562.5 IU vs. 1462.5 ± 645.0, P = 0.15), without compromising clinical pregnancy rate (PR) (71.8% vs. 70.9%, P = NS) or delivery/ongoing PR (58.2% vs. 62.1%, P = NS). There were no differences in age, body mass index (BMI), peak estradiol, peak progesterone, retrieved oocytes, fertilized oocytes, number of ET, or PR.
  
  
  CONCLUSIONS
  Once daily administration is associated with lower gonadotropin usage without compromising success rates.
authors.affiliation: Virginia Center for Reproductive Medicine, Reston, VA 20190, USA. fsharara@aol.com
authors.forename: Fady I
authors.initials: FI
authors.lastname: Sharara
authors.forename: Michael G
authors.initials: MG
authors.lastname: Collins
authors.forename: Galal
authors.initials: G
authors.lastname: Abdo
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins