title: New functionalizable alkyltrichlorosilane surface modifiers for biosensor and biomedical applications.
abstract: We report herein three unprecedented alkyltrichlorosilane surface modifiers bearing pentafluorophenyl ester (PFP), benzothiosulfonate (BTS), or novel β-propiolactone (BPL) functionalizable terminal groups. Evidence is provided that these molecules can be prepared in very high purity (as assessed by NMR) through a last synthetic step of Pt-catalyzed alkene hydrosilylation then directly employed, without further purification, for the surface modification of quartz and medical grade stainless steel. Subsequent on-surface functionalizations with amine and thiol model molecules demonstrate the potential of these molecular adlayers to be important platforms for future applications in the bioanalytical and biomedical fields.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6.
authors.forename: Christophe
authors.initials: C
authors.lastname: Blaszykowski
authors.forename: Sonia
authors.initials: S
authors.lastname: Sheikh
authors.forename: Pasquale
authors.initials: P
authors.lastname: Benvenuto
authors.forename: Michael
authors.initials: M
authors.lastname: Thompson
mesh_terms: D020811:Biomedical Technology; D015374:Biosensing Techniques; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D012821:Silanes; C065893:trichlorosilane