title: The auditory brainstem response: latencies obtained in children while under general anesthesia.
abstract: BACKGROUND
  The auditory brainstem response (ABR) test is frequently employed to estimate hearing sensitivity and assess the integrity of the ascending auditory system. In persons who cannot participate in conventional tests of hearing, a short-acting general anesthetic is used, recordings are obtained, and the results are compared with normative data. However, several factors (e.g., anesthesia, temperature changes) can contribute to delayed absolute and interpeak latencies, making it difficult to evaluate the integrity of the person's auditory brainstem function.
  
  
  OBJECTIVE
  In this study, we investigated the latencies of ABR responses in children who received general anesthesia.
  
  
  METHODS
  Between subject.
  
  
  METHODS
  Twelve children between the ages of 29 and 52 mo, most of whom exhibited a developmental delay but normal peripheral auditory function, comprised the anesthesia group. Twelve participants between the ages of 13 and 26 yr with normal hearing thresholds comprised the control group.
  
  
  METHODS
  ABRs from a single ear from children, recorded under general anesthesia, were retrospectively analyzed and compared to those obtained from a control group with no anesthesia. ABRs were generated using 80 dB nHL rarefaction click stimuli. T-tests, corrected for alpha slippage, were employed to examine latency differences between groups.
  
  
  RESULTS
  There were significant delays in latencies for children evaluated under general anesthesia compared to the control group. Delays were observed for wave V and the interpeak intervals I-III, III-V, and I-V.
  
  
  CONCLUSIONS
  Our data suggest that caution is needed in interpreting neural function from ABR data recorded while a child is under general anesthesia.
authors.affiliation: Speech, Language and Hearing Sciences, University of Arizona, Tucson, AZ 85721-0071, USA. norrix@email.arizona.edu
authors.forename: Linda W
authors.initials: LW
authors.lastname: Norrix
authors.forename: Stacey
authors.initials: S
authors.lastname: Trepanier
authors.forename: Matthew
authors.initials: M
authors.lastname: Atlas
authors.forename: Darlyne
authors.initials: D
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001306:Auditory Pathways / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods* / Q000592:standards* / Q000706:statistics & numerical data; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D015588:Observer Variation; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D011897:Random Allocation; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D012189:Retrospective Studies; D055815:Young Adult