title: [Pompholyx-like reactions occurring early in treatment of severe atopic dermatitis in children and adolescence].
abstract: BACKGROUND
  Pompholyx-like reactions may develop for aggressive atopic dermatitis treatments in the incipient phase despite of improvement of other skin symptoms.
  
  
  METHODS
  Eighty-nine patients admitted to National Center for Child Health and Development for treatment of atopic dermatitis between April 2007 and March 2009 were recruited.
  
  
  RESULTS
  Pompholyx-like reactions were seen in thirteen out of eighty-nine patients between 4 and 32 (mean 16.7±10.4) days following admission. The mean age of patients with these reactions was 6.2±6.1 years (range of 3 months to 23 years). At the time of admission, practical issues of scoring atopic dermatitis: the SCORAD was assessed. The values of SCORAD index with pompholyx were ranging from 16-91 (mean 50.8±17.9), and the index except under one-year old were significantly higher than unaffected patients. These patients were evaluated into their medical record, for evidence of Pompholyx-like lesions: a bilateral vesicular eruption confined to the skin of the palms, soles, or sides of the fingers. Topical corticosteroids are used to treat Pompholyx-like reactions, all them achieved remission between 4 and 50 days (mean 18.5±12.0). In general, pompholyx is more common in summer. However, it seems that there were no significant differences in the pompholyx-like reactions incidence between in summer and in winter.
  
  
  CONCLUSIONS
  The factor for the occurrence of pompholyx-like lesions remains unexplained. Although the original symptoms of eczema were improved, pompholyx-like eczema breakout, therefore, patients often feel uneasy. We should be aware of this clinical condition.
authors.affiliation: Division of Allergy, Department of Medical Specialties, National Center for Child Health and Development. horimukai-k@ncchd.go.jp
authors.forename: Kenta
authors.initials: K
authors.lastname: Horimukai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tsumura
authors.forename: Kiwako
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoda
authors.forename: Masaki
authors.initials: M
authors.lastname: Futamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nomura
authors.forename: Masami
authors.initials: M
authors.lastname: Narita
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ohya
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications* / Q000188:drug therapy; D011146:Eczema, Dyshidrotic / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D055815:Young Adult