title: Multi-scale modelling of elastic moduli of trabecular bone.
abstract: We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.
authors.affiliation: Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Elham
authors.initials: E
authors.lastname: Hamed
authors.forename: Iwona
authors.initials: I
authors.lastname: Jasiuk
authors.forename: Andrew
authors.initials: A
authors.lastname: Yoo
authors.forename: Yikhan
authors.initials: Y
authors.lastname: Lee
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Liszka
mesh_terms: D000369:Aged, 80 and over; D004548:Elasticity / Q000502:physiology*; D004838:Epiphyses / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008954:Models, Biological; D013977:Tibia / Q000502:physiology* / Q000648:ultrastructure*