title: Regional differences in predictive accuracy of WHO immunologic failure criteria.
abstract: We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.
authors.affiliation: College of Health Sciences, Infectious Diseases Institute, Uganda. akiragga@idi.co.ug
authors.forename: Agnes N
authors.initials: AN
authors.lastname: Kiragga
authors.forename: Barbara
authors.initials: B
authors.lastname: Castelnuovo
authors.forename: Moses R
authors.initials: MR
authors.lastname: Kamya
authors.forename: Richard
authors.initials: R
authors.lastname: Moore
authors.forename: Yukari C
authors.initials: YC
authors.lastname: Manabe
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008297:Male; D012111:Residence Characteristics; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D017211:Treatment Failure; D014454:Uganda; D014481:United States; D019562:Viral Load
chemical_list: D018894:Reverse Transcriptase Inhibitors