title: Circulating levels of resistin, IL-6 and lipid profile in elderly patients with ischemic heart disease with and without diabetes.
abstract: BACKGROUND
  The cytokines that act as inflammatory hormones show a role in coronary atherosclerotic disease.
  
  
  OBJECTIVE
  This study aimed to measure serum resistin, IL-6 levels and lipid profile in nondiabetic controls, diabetics, and ischemic heart disease subjects with and without diabetes. Association between resistin and IL-6 was also determined.
  
  
  METHODS
  In this comparative cross-sectional study, 147 subjects were selected, aged between 40 and 70 years. Subjects were divided into four groups as mentioned above. Plasma glucose was measured using the gluco-oxidase method. Lipid profile levels were measured using standard enzymatic methods. Levels of resistin and IL-6 were determined by ELISA.
  
  
  RESULTS
  Out of 147 patients, 36 were controls and 111 were cases. Serum resistin and IL-6 levels increased significantly in diabetics (23.4 ± 0.74 ng/ml and 73.1 ± 2.57 ng/ml, respectively) and nondiabetics with ischemic heart disease (14.1 ± 0.51 ng/ml and 66.2 ± 2.08 ng/ml, respectively) compared with diabetics and nondiabetic controls. Positive correlations were found between IL-6 and resistin, and a significant positive correlation was shown in ischemic heart disease groups (r = 0.659; p = 0.001).
  
  
  CONCLUSIONS
  This study shows that the plasma resistin and IL-6 concentrations increased significantly in patients with ischemic heart disease with and without diabetes. This shows that there is a possible role of resistin and IL-6 in inflammatory processes, especially in atherosclerosis.
authors.affiliation: Department of Biochemistry, Ziauddin University, Karachi, Pakistan. drfais@hotmail.com
authors.forename: Faisal
authors.initials: F
authors.lastname: Yaseen
authors.forename: Anila
authors.initials: A
authors.lastname: Jaleel
authors.forename: Jawed
authors.initials: J
authors.lastname: Aftab
authors.forename: Adnan
authors.initials: A
authors.lastname: Zuberi
authors.forename: Ejaz
authors.initials: E
authors.lastname: Alam
mesh_terms: D000328:Adult; D000368:Aged; D048909:Diabetes Complications / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications*; D052243:Resistin / Q000097:blood*
chemical_list: D015850:Interleukin-6; D008055:Lipids; D052243:Resistin