title: Lack of association between essential hypertension and GSTO1 uncommon genetic variants in Italian patients.
abstract: OBJECTIVE
  Essential hypertension (EH) is a complex phenotype that is affected by multiple genetic and environmental factors. Some authors have explored the role of genetic variability of the glutathione S-transferase (GST) enzymes in EH risk with contrasting results. In particular, our previous study investigated two GSTO common polymorphisms, but we did not find a significant outcome. The aim of this research was to analyze two GSTO1 uncommon variants (E155del and E208K) in 193 EH patients and 210 healthy controls.
  
  
  RESULTS
  The genetic association analysis did not find significant outcome between GSTO1 uncommon variants and EH: both single-locus and haplotype investigations did not reach the statistical significance levels. Nevertheless, the correspondence analysis seems to highlight a difference between sexes: female EH patients seem to be more related to E155/del155 and E208/K208 genotypes than male patients.
  
  
  CONCLUSIONS
  Our studies confirm the lack of association between GSTO1 variants and EH risk, also for two uncommon genetic variants with large functional effects. However, our study highlighted some hypotheses (sex-specific marker, antioxidant function, arsenic metabolism, and modulation of inflammation processes) that might help to clarify the potential role of GSTO1 in EH pathophysiology.
authors.affiliation: Department of Biology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Polimanti
authors.forename: Sara
authors.initials: S
authors.lastname: Piacentini
authors.forename: Natalia
authors.initials: N
authors.lastname: Lazzarin
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Re
authors.forename: Dario
authors.initials: D
authors.lastname: Manfellotto
authors.forename: Maria
authors.initials: M
authors.lastname: Fuciarelli
mesh_terms: D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007558:Italy; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D044465:White People / Q000235:genetics
chemical_list: C490476:GSTO1 protein, human; D005982:Glutathione Transferase