title: Clinical and research diagnostic criteria for Alzheimer's disease.
abstract: In contrast with the previous criteria published in 1984 by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association, the new criteria proposed in 2007 incorporated in the diagnostic framework the use of biomarkers that are able to assess the underlying pathophysiologic mechanism. The combination of clinical and biologic approaches makes a diagnosis of Alzheimer's disease possible before the dementia stage. The core clinical criteria continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the specificity for the diagnosis of Alzheimer's disease.
authors.affiliation: Université Pierre et Marie Curie Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, UMR-S975, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. marie.sarazin@psl.aphp.fr
authors.forename: Marie
authors.initials: M
authors.lastname: Sarazin
authors.forename: Leonardo Cruz
authors.initials: LC
authors.lastname: de Souza
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lehéricy
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
mesh_terms: D000544:Alzheimer Disease / Q000145:classification* / Q000175:diagnosis*; D035843:Biomedical Research / Q000592:standards*; D015510:Clinical Medicine / Q000592:standards*; D006801:Humans; D059906:Neuroimaging / Q000592:standards*; D017410:Practice Guidelines as Topic; D014481:United States