title: Association between γ-glutamyltransferase and prehypertension.
abstract: Researchers have identified an association between baseline γ-glutamyltransferase (GGT) and prehypertension. However, data from China are limited. A cross-sectional study was performed among 2,205 subjects from Heilongjiang Province in China. Multiple logistic regression analyses revealed a significant association between baseline GGT and prehypertension [1.59, 95% conﬁdence interval (CI), 1.18-2.16], comparing quartile 4 to quartile 1. Subgroup analyses showed a stronger association between GGT and prehypertension in Koreans; men, current alcohol drinkers and subjects with pre-diabetes. Receiver operating characteristics (ROC) analysis demonstrated that when GGT was higher than 20 U/l, the risk of developing prehypertension increased. Serum GGT is used as a biochemical liver test, but our findings suggest that baseline values may also predict prehypertension in Chinese.
authors.affiliation: Department of Clinical Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, PR China.
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Qin
authors.forename: Guodong
authors.initials: G
authors.lastname: Tang
authors.forename: Ling
authors.initials: L
authors.lastname: Qiu
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Xinqi
authors.initials: X
authors.lastname: Cheng
authors.forename: Shaomei
authors.initials: S
authors.lastname: Han
authors.forename: Guangjin
authors.initials: G
authors.lastname: Zhu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058246:Prehypertension / Q000175:diagnosis* / Q000201:enzymology*; D012372:ROC Curve; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000032:analysis*
chemical_list: D005723:gamma-Glutamyltransferase