title: Obesity but not overweight increases the incidence and mortality of leukemia in adults: a meta-analysis of prospective cohort studies.
abstract: The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associated with a relative risk (RR) of 1.26 (95% CI 1.17-1.37; p < 0.001) for leukemia incidence and 1.29 (95% CI 1.11-1.49; p = 0.001) for mortality. Obesity was also associated with an increased incidence of acute myeloid leukemia (RR 1.53, 95% CI 1.26-1.85; p<0.001), chronic lymphocytic leukemia (RR 1.17, 95% CI 1.08-1.27; p < 0.001), chronic myeloid leukemia (RR 1.16, 95% CI 1.04-1.30; p = 0.007) and acute lymphoblastic leukemia (RR 1.62, 95% CI 1.12-2.32; p = 0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men.
authors.affiliation: Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. jcastillo@lifespan.org
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.forename: John L
authors.initials: JL
authors.lastname: Reagan
authors.forename: Randall R
authors.initials: RR
authors.lastname: Ingham
authors.forename: Michael
authors.initials: M
authors.lastname: Furman
authors.forename: Samir
authors.initials: S
authors.lastname: Dalia
authors.forename: Basma
authors.initials: B
authors.lastname: Merhi
authors.forename: Saed
authors.initials: S
authors.lastname: Nemr
authors.forename: Ali
authors.initials: A
authors.lastname: Zarrabi
authors.forename: Joanna
authors.initials: J
authors.lastname: Mitri
mesh_terms: D000328:Adult; D000465:Algorithms; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000150:complications* / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality*; D008297:Male; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D050177:Overweight / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis