title: XRCC1 polymorphisms and risk of nasopharyngeal carcinoma: a meta-analysis.
abstract: OBJECTIVE
  Previous studies on the association between X-ray repair cross-complementing protein 1 (XRCC1) polymorphisms and nasopharyngeal carcinoma (NPC) risk showed inconsistent results. The aim of this study was to evaluate the effects of XRCC1 variants on NPC risk.
  
  
  METHODS
  A meta-analysis was performed with all eligible studies covering a total of 1,341 cases and 1,425 controls for the Arg194Trp polymorphism, 1,260 cases and 1,207 controls for the Arg280His polymorphism, and 1,644 cases and 1,678 controls for the Arg399Gln polymorphism.
  
  
  RESULTS
  No associations was found between Arg194Trp and Arg280His polymorphisms with NPC risk under all contrast models (co-dominant, dominant, and recessive models). However a deleterious effect of the 399Gln genotype was observed under the co-dominant model (Gln/Gln versus Arg/Arg, OR = 1.30, 95% CI : 1.01-1.69, P = 0.04). Under the recessive model (Gln/Gln versus Arg/Arg+Arg/Gln), the P value was marginally significant (OR = 1.28, 95% CI : 1.00-1.65, P = 0.05). However, the effect of the 399Gln genotype on NPC became non-significant after excluding one study from the meta-analysis because of departure from Hardy-Weinberg equilibrium.
  
  
  CONCLUSIONS
  No associations were found between Arg194Trp and Arg280His polymorphisms with NPC risk, whereas the Arg399Gln genotype was associated with increased risk.
authors.affiliation: Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Huang
authors.forename: Hong-Qiang
authors.initials: HQ
authors.lastname: Guo
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Yu
authors.forename: Xing-Yan
authors.initials: XY
authors.lastname: Liu
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Li
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wu
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: He
mesh_terms: D044466:Asian People / Q000235:genetics; D002277:Carcinoma; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human