title: Administration, distribution, metabolism and elimination of polymer therapeutics.
abstract: Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.
authors.affiliation: Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Ela
authors.initials: E
authors.lastname: Markovsky
authors.forename: Hemda
authors.initials: H
authors.lastname: Baabur-Cohen
authors.forename: Anat
authors.initials: A
authors.lastname: Eldar-Boock
authors.forename: Liora
authors.initials: L
authors.lastname: Omer
authors.forename: Galia
authors.initials: G
authors.lastname: Tiram
authors.forename: Shiran
authors.initials: S
authors.lastname: Ferber
authors.forename: Paula
authors.initials: P
authors.lastname: Ofek
authors.forename: Dina
authors.initials: D
authors.lastname: Polyak
authors.forename: Anna
authors.initials: A
authors.lastname: Scomparin
authors.forename: Ronit
authors.initials: R
authors.lastname: Satchi-Fainaro
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000493:pharmacokinetics*; D006801:Humans; D011108:Polymers / Q000493:pharmacokinetics*
chemical_list: D004337:Drug Carriers; D011108:Polymers