title: Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.
abstract: BACKGROUND
  The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has been found to correlate with some diseases, tumor progression, and defective morphogenesis. Investigating the pattern of claudin expression during embryogenesis or in certain pathological conditions is necessary to begin disclosing the role of these proteins in health and disease.
  
  
  RESULTS
  This study analyzed the expression of several claudins during mouse pancreas organogenesis and in pancreatic intraepithelial neoplasias of mouse and human origin.
  
  
  CONCLUSIONS
  Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation.
authors.affiliation: Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Joby J
authors.initials: JJ
authors.lastname: Westmoreland
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Drosos
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Kelly
authors.forename: Jianming
authors.initials: J
authors.lastname: Ye
authors.forename: Anna L
authors.initials: AL
authors.lastname: Means
authors.forename: M Kay
authors.initials: MK
authors.lastname: Washington
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sosa-Pineda
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D057167:Claudins / Q000235:genetics / Q000378:metabolism*; D004848:Epithelium / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009024:Morphogenesis; D038081:Organogenesis; D010179:Pancreas / Q000196:embryology* / Q000378:metabolism / Q000473:pathology*; D010183:Pancreatic Ducts / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D057167:Claudins