title: Impact of footrot vaccination and antibiotic therapy on footrot and contagious ovine digital dermatitis.
abstract: Footrot and contagious ovine digital dermatitis (CODD) are common causes of foot disease of sheep in the UK. The study reported here is a split flock randomised treatment trial undertaken on a group of 748 fattening lambs on a UK sheep farm affected by CODD and footrot. The sheep were randomly assigned to one of two treatment protocols. In protocol A, all sheep were given two doses of footrot vaccine (Footvax, MSD), plus targeted antibiotic therapy (long-acting amoxicillin, Betamox LA, Norbrook Pharmaceuticals) to sheep with foot lesions likely to be associated with a bacterial infection. In protocol B, the sheep only received targeted antibiotic therapy. Sheep were re-examined and foot lesions recorded five and nine weeks later. New infection rates in the footrot vaccinated group were lower compared with the vaccinated group for both CODD (18.2 per cent compared with 26.4 per cent, P=0.014) and footrot (12.55 per cent compared with 27.5 per cent, P<0.001). Recovery rates were unaffected for CODD (80.46 per cent compared with 70.97 per cent, P=0.14) but higher for footrot (92.09 per cent compared with 81.54 per cent, P=0.005) in sheep which received the vaccine. On this farm, a footrot vaccine efficacy of 62 per cent was identified against footrot and 32 per cent against CODD infection. An association between a sheep having footrot at visit 1 and subsequently acquiring CODD was identified (odds ratio [OR] 3.83, 95 per cent CI 2.61 to 5.62, P<0.001). These results suggest a role for infection with Dichelobacter nodosus in the aetiopathogenesis of CODD on this farm.
authors.affiliation: School of Veterinary Science, Faculty of Medical and Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU. jsduncan@liverpool.ac.uk
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
authors.forename: D
authors.initials: D
authors.lastname: Grove-White
authors.forename: E
authors.initials: E
authors.lastname: Moks
authors.forename: D
authors.initials: D
authors.lastname: Carroll
authors.forename: J W
authors.initials: JW
authors.lastname: Oultram
authors.forename: C J
authors.initials: CJ
authors.lastname: Phythian
authors.forename: H W
authors.initials: HW
authors.lastname: Williams
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D020376:Dichelobacter nodosus / Q000187:drug effects / Q000472:pathogenicity*; D058066:Digital Dermatitis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005535:Foot Rot / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines