title: Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated             respiratory disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome that             is characterized by nasal polyposis, general symptoms of asthma and sensitive             response to non-steroidal anti-inflammatory drugs (NSAIDs). Although the exact             function of tripartite motif-containing 26 (TRIM26) still remains unknown, the             gene functions in the immune response. Thus, we hypothesized that TRIM26 polymorphisms             may affect aspirin-induced bronchospasm and explored whether the gene can be a             marker for diagnosis of AERD. To investigate our hypothesis that TRIM26 may serve             as a genetic marker for diagnosis of AERD, this study focused on demonstrating             the associations between single nucleotide polymorphisms (SNPs) of the TRIM26             gene and AERD. We genotyped 18 polymorphisms of TRIM26 in a total of 189 asthmatics             and examined their associations with the risk of AERD. We performed logistic analysis             for obtaining P-values and regression analysis for demonstrating an association             between the phenotype with FEV1 and the genotype. We observed no associations             between polymorphisms in TRIM26 and the risk of AERD in both logistic and regression             analyses. Although our results reveal a lack of association, the suggested functional             role of TRIM26 makes it a putative candidate gene for AERD. Thus, replications             in other populations using larger samples may provide valuable information for             AERD etiology.
authors.affiliation: Department of Life Science, Sogang University, Seoul 121-742,                     Republic of Korea.
authors.forename: Jin Sol
authors.initials: JS
authors.lastname: Lee
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jason Yongha
authors.initials: JY
authors.lastname: Kim
authors.forename: Tae Joon
authors.initials: TJ
authors.lastname: Park
authors.forename: Charisse Flerida
authors.initials: CF
authors.lastname: Pasaje
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: An-Soo
authors.initials: AS
authors.lastname: Jang
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055963:Asthma, Aspirin-Induced / Q000209:etiology / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012307:Risk Factors; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D000070584:Tripartite Motif Proteins; C519439:TRIM26 protein, human; D044767:Ubiquitin-Protein Ligases