title: Two-year follow-up of treatment of intrabony periodontal defect with enamel matrix derivative.
abstract: The aim of this retrospective clinical study was to evaluate 2-year follow-up results following regenerative periodontal surgery for intrabony defects using enamel matrix derivative (EMD). Thirteen patients (mean age: 53 years) with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 sites with intrabony defects received regenerative therapy with EMD. Follow-up continued for a minimum of 2 years. Treatment of intrabony defects with EMD yielded a statistically significant improvement in the mean values of probing depth and gains in clinical attachment level (CAL) at 2 years compared with those at baseline (p<0.001). Sites treated with EMD demonstrated a mean CAL gain of 3.4 mm and 3.2 mm at 6 months and 2 years, respectively. No statistically significant difference in gain in CAL was found between the 6-month and 2-year results. A gain in CAL of ≥3 mm from at baseline was found in 17 sites at 2 years. This gain was achieved with minimal recession of gingival margin and was sustained over a given period of time. A trend toward a progressive increase in radiopacity, suggestive of bone-fill, was observed. In summary, treatment of intrabony defects with EMD resulted in clinically favorable outcomes. The clinical improvements obtained with regenerative therapy with EMD were maintained over a period of 2 years.
authors.affiliation: Division of Conservative Dentistry, Department of Clinical Oral Health Science, Tokyo Dental College, Japan.
authors.forename: Koushu
authors.initials: K
authors.lastname: Fujinami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Kei
authors.initials: K
authors.lastname: Ota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ida
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nikaido
authors.forename: Takemi
authors.initials: T
authors.lastname: Makiishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D003746:Dental Enamel Proteins; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D003746:Dental Enamel Proteins