title: Natural products as leads for tuberculosis drug development.
abstract: New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.
authors.affiliation: Center for Drug Design, University of Minnesota, Minneapolis MN 55455, USA. csalomon@umn.edu
authors.forename: Christine E
authors.initials: CE
authors.lastname: Salomon
authors.forename: Lori E
authors.initials: LE
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products