title: [Effects of a Cetraria islandica extract in monotherapy and in association with magnesium in an experimental-induced hepatopathy model].
abstract: OBJECTIVE
  To investigate the effects of a Cetraria islandica extract in an animal model of hepatopathy.
  
  
  METHODS
  The experiments were carried out on Wistar rats, treated intraperitoneally (excepting carbon tetrachloride which was administered orally by esogastric tube), at single daily dose, for 28 days and divided in eight groups of 6 rats each: Group 1: Saline solution (0.5ml/100g bw/day); Group 2: MgSO4 (5mg/kbw/day); Group 3: C. islandica (Ci) extract (21.56mg/kbw/day); Group 4: Ci+MgSO4; Group 5: carbon tetrachloride (CT).(0.1 ml/100g bw/day); Group 6: CT+MgSO4; Group 7: CT+Ci; Group 8: CT+Ci+MgSO4. At the end of the experiment blood samples were taken to assess the effects on the blood parameters,TGO, TGP, GGT, LDH, serum total billirubin, neutrophil phagocytic function (Nitroblue tetrazolium test) and serum complement activity. This parameters were determined with VITROS 750 XRC device, using Johnson&Johnson kits. The results were statistically processed with the help of "t-Student" test. p<0.05 was considered statistically significant.
  
  
  RESULTS
  In this carbon tetrachloride-induced hepatopathy animal model, C. islandica extract demonstrated hepatoprotective and immuno-stimulating effects (proved by normalization of glutamic-pyruvic transminase, glutamic-oxalocetic transminase, serum total billirubin, stimulation of neutrophils percentage and phagocytic functions, decreasing the carbon tetrachloride-induced basophilia and monocytosis, especially in association with magnesium).
  
  
  CONCLUSIONS
  Further studies are required to confirm the benefits of this association in hepatoprotective and immunomodulating therapies.
authors.affiliation: Universităţii de Medicină şi Farmacie "Gr. T. Popa" Iaşi.
authors.forename: Irina Teodora
authors.initials: IT
authors.lastname: Cernescu
authors.forename: Liliana
authors.initials: L
authors.lastname: Tarţău
authors.forename: Antonela
authors.initials: A
authors.lastname: Macavei
authors.forename: Cătălina-Elena
authors.initials: CE
authors.lastname: Lupuşoru
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D008011:Lichens; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D008274:Magnesium / Q000008:administration & dosage*; D009504:Neutrophils / Q000166:cytology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008076:Cholesterol, HDL; D010936:Plant Extracts; D003165:Complement System Proteins; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008274:Magnesium; D001663:Bilirubin