title: New flavan and benzil isolated from Fissistigma latifolium.
abstract: Further investigation of the methanolic extract of Fissistigma latifolium resulted in two new compounds whose structures were assigned as 2,5,6,7-tetramethoxyflavan (1) and 2'-hydroxy-4',5',6'-trimethoxybenzil (2). These two compounds were determined on the basis of chemical and spectroscopic evidences. Compound 2 is the first report of benzil from Fissistigma species. 2,5,6,7-Tetramethoxyflavan (1) showed a potent inhibitory effect on superoxide anion production in formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)/cytochalasin B (CB)-activated human neutrophils.
authors.affiliation: School of Pharmacy, China Medical University, Taichung, Taiwan.
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Lan
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Peng
authors.forename: Tran-Dinh
authors.initials: TD
authors.lastname: Thang
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Do-Ngoc
authors.initials: DN
authors.lastname: Dai
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Lai
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010658:Phenylglyoxal / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: C572646:2'-hydroxy-4',5',6'-trimethoxybenzil; C572645:2,5,6,7-tetramethoxyflavan; D004791:Enzyme Inhibitors; D005419:Flavonoids; D013481:Superoxides; D010658:Phenylglyoxal; C006697:benzil