title: Modulation of intestinal brush border membrane chemical composition during postnatal development in rats: effect of gestational diabetes.
abstract: There was a significant increase in fucose (52%), total hexoses (16%) and hexosamine (56%) except sialic acid, which was reduced (77%) in the microvillus membrane of infants born to rat mothers made diabetic by injecting alloxan on day 3 of gestation. Expressed on the protein basis there were a significant increase in membrane, triglyceride, total cholesterol, and phospholipids content of brush border in pups from diabetic group between 5-45 days of postnatal age. Intestinal morphology in diabetic group showed, regression of tubular glands, distorted cellular organization of mucosal cells, reduction in the mucosal cell height and number of secretory goblet cells. These findings suggest that the gestational diabetes affects the sugar and lipid composition of the intestinal brush border membrane in rats during early stages of the postnatal development, which may be associated with compromised tissue functions later in life.
authors.affiliation: Department of Biotechnology, Government College for Girls, Chandigarh, 160 036, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Sharma
authors.forename: Shailender Singh
authors.initials: SS
authors.lastname: Chauhan
authors.forename: Akhtar
authors.initials: A
authors.lastname: Mahmood
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D007408:Intestinal Absorption; D007422:Intestines / Q000503:physiopathology*; D008563:Membrane Lipids / Q000032:analysis; D008871:Microvilli / Q000737:chemistry* / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000032:analysis
chemical_list: D008563:Membrane Lipids; D014280:Triglycerides