title: Adolescent experiences in a vaccine trial: a pilot study.
abstract: Little is known about how adolescents experience clinical trials. We assessed the experiences of South African adolescent participants in a clinical trial, employing semi-structured interviews to gather qualitative data on the experiences and effects of trial participation. Despite misunderstanding certain concepts regarding assent and trial processes subsequent to enrollment, participants reported positive experiences overall. Subjects' motivations for participation included: an ability to help others; receipt of healthcare; and free blood screening. Participants expressed fears associated with trial procedures, such as phlebotomy; however, these apprehension diminished as the trial progressed. We found that conducting qualitative research within a trial site is feasible, and can provide insight into the uptake and acceptability of interventions.
authors.affiliation: South African Cochrane Centre/ South African Medical Research Council. amber.abrams@mrc.ac.za
authors.forename: Amber
authors.initials: A
authors.lastname: Abrams
authors.forename: Nandi
authors.initials: N
authors.lastname: Siegfried
authors.forename: Hennie
authors.initials: H
authors.lastname: Geldenhuys
mesh_terms: D000293:Adolescent; D017321:Clinical Trials, Phase I as Topic; D005260:Female; D006801:Humans; D007258:Informed Consent; D008297:Male; D009042:Motivation; D018579:Patient Selection; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic