title: Pre-sampling ultrasound evaluation and assessment of the tissue yield during sampling improves the diagnostic reliability of office endometrial biopsy.
abstract: We evaluated the implementation of a strict procedure for endometrium biopsy, including pre-sampling ultrasound examination and assessment of the tissue yield during sampling, in 257 consecutive women with abnormal bleeding. The tissue yield was assessed during sampling and scored from 1 to 4. The median endometrial thickness as measured by ultrasound was 5.0 mm, 5.1 mm, 10.0 mm and 18.7 mm for a tissue yield score of 1, 2, 3 and 4, respectively. The median endometrial thickness at ultrasound and the median tissue yield score was 18.3 mm and score 4 in the endometrial cancer cases, compared with 3.9 mm and score 1, and 14.8 mm and score 3 in the case of endometrial atrophy and hyperplasia, respectively; and 11.5 mm and score 2 in endometrial polyp cases. Overall, 12 cancers were diagnosed. No endometrial cancer was diagnosed during follow-up (median 447 days). A strict office endometrial biopsy procedure contributes to the diagnostic reliability for intracavitary pathology.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospitals Leuven, K. U. Leuven, Belgium. thierry.van.den.bosch@skynet.be
authors.forename: T
authors.initials: T
authors.lastname: Van den Bosch
authors.forename: D
authors.initials: D
authors.lastname: Van Schoubroeck
authors.forename: B
authors.initials: B
authors.lastname: Van Calster
authors.forename: A
authors.initials: A
authors.lastname: Cornelis
authors.forename: D
authors.initials: D
authors.lastname: Timmerman
mesh_terms: D001707:Biopsy, Needle; D004714:Endometrial Hyperplasia / Q000175:diagnosis / Q000000981:diagnostic imaging; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D004715:Endometriosis / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014463:Ultrasonography