title: Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD.
abstract: COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD. The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). Homozygous Val/Val children showed a higher prevalence of ADHD comorbid with DBD (χ(2) = 5.762; p = 0.016; OR = 1.58; CI(95%) = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD.
authors.affiliation: Departamento de Genética, Instituto de Biociências, UFRGS, Caixa Postal 15053, Porto Alegre, RS 91501-970, Brazil.
authors.forename: Angélica
authors.initials: A
authors.lastname: Salatino-Oliveira
authors.forename: Julia P
authors.initials: JP
authors.lastname: Genro
authors.forename: Ana P
authors.initials: AP
authors.lastname: Guimarães
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Chazan
authors.forename: Cristian
authors.initials: C
authors.lastname: Zeni
authors.forename: Marcelo
authors.initials: M
authors.lastname: Schmitz
authors.forename: Guilherme
authors.initials: G
authors.lastname: Polanczyk
authors.forename: Tatiana
authors.initials: T
authors.lastname: Roman
authors.forename: Luis A
authors.initials: LA
authors.lastname: Rohde
authors.forename: Mara H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000293:Adolescent; D000483:Alleles; D019943:Amino Acid Substitution; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D001938:Brazil / Q000453:epidemiology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D015897:Comorbidity; D019955:Conduct Disorder / Q000235:genetics / Q000523:psychology; D004247:DNA / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D014633:Valine / Q000235:genetics
chemical_list: D004247:DNA; D002394:Catechol O-Methyltransferase; D014633:Valine