title: Managing incidentally diagnosed isolated factor VII deficiency perioperatively: a brief expert consensus report.
abstract: While isolated factor VII (FVII) deficiency is being more frequently diagnosed owing to improved preoperative screening procedures, there is no specific guideline for perioperative management of such patients. To complicate the issue, FVII activity levels seem to correlate less well with the risk of hemorrhage than the patient's past and family bleeding history do. We have devised expert consensus recommendations for managing such patients perioperatively, taking into consideration the personal and family bleeding history, the FVII activity level and the inherent bleeding risk of the procedure itself. We hope that clinicians will find this a useful tool in the decision-making process, thereby limiting the use of recombinant factor VIIa to those who need it most, and preventing possible thrombotic complications in those without a strong indication for its use.
authors.affiliation: Columbia University Medical Center, NY, USA.
authors.forename: Sujit
authors.initials: S
authors.lastname: Sheth
authors.forename: Gerald
authors.initials: G
authors.lastname: Soff
authors.forename: Beau
authors.initials: B
authors.lastname: Mitchell
authors.forename: David
authors.initials: D
authors.lastname: Green
authors.forename: Shipra
authors.initials: S
authors.lastname: Kaicker
authors.forename: Fernando
authors.initials: F
authors.lastname: Fireman
authors.forename: Oya
authors.initials: O
authors.lastname: Tugal
authors.forename: Ludovico
authors.initials: L
authors.lastname: Guarini
authors.forename: Patricia
authors.initials: P
authors.lastname: Giardina
authors.forename: Louis
authors.initials: L
authors.lastname: Aledort
mesh_terms: D005167:Factor VII / Q000008:administration & dosage / Q000009:adverse effects; D005168:Factor VII Deficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D019990:Perioperative Care / Q000379:methods
chemical_list: D005167:Factor VII