title: [Key elements of design about PPK of Chinese medicine after marketing].
abstract: PPK is a discipline that quantitative investigates the determinants of drug concentration in patient groups. Developing reasonable PPK design of experiment can provides the real objective data for clinical medicationand then promotes the formulating of clinical individualized medication regimens. This paper referenced over all years literatures, and combined with practical work experience. Summarizes of the main points of PPK design of experiment focused on traditional Chinese medicine. The content mainly included choosing research objects, selecting items, designing sample collection steps, blood sample analysis experiments and data analysis schemes.
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. wangjiannon2008@sina.com
authors.forename: Jiannong
authors.initials: J
authors.lastname: Wang
authors.forename: Junjie
authors.initials: J
authors.lastname: Jiang
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xie
mesh_terms: D006801:Humans; D008516:Medicine, Chinese Traditional; D010599:Pharmacokinetics; D011358:Product Surveillance, Postmarketing; D012107:Research Design