title: Tuberculosis among household contacts of multidrug-resistant tuberculosis patients in Delhi, India.
abstract: METHODS
  Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases (LRS), a tertiary level tuberculosis (TB) institute in Delhi, India.
  
  
  OBJECTIVE
  To study the profile of TB among household contacts of multidrug-resistant TB (MDR-TB) patients.
  
  
  METHODS
  In a cross-sectional study, contacts of MDRTB patients were traced and clinical, radiological, bacteriological and pulmonary function tests were performed for evidence of TB infection and active disease.
  
  
  RESULTS
  Between January 2005 and December 2008, 58 of 92 index MDR-TB patients could be traced. Of 302 contacts who could be studied, 16 (5.29%) developed TB: nine had pulmonary and seven had extra- pulmonary disease; two (0.66%) had MDR-TB. Of the 302 contacts, 137 reported to the LRS Institute and were investigated. The most common symptoms observed were cough, chest pain and fever. The tuberculin skin test was positive in 109 of 135 (80.7%) contacts; among these, bacille Calmette-Guérin scar was present in 86. Pulmonary function tests revealed obstruction, restriction and mixed abnormalities.
  
  
  CONCLUSIONS
  The majority of contacts of MDR-TB patients had drug-susceptible TB and the rate of MDRTB was very low. Evaluation of contacts of MDR-TB cases may lead to early diagnosis and prevention of TB.
authors.affiliation: Department of Epidemiology, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
authors.forename: N
authors.initials: N
authors.lastname: Singla
authors.forename: R
authors.initials: R
authors.lastname: Singla
authors.forename: G
authors.initials: G
authors.lastname: Jain
authors.forename: L
authors.initials: L
authors.lastname: Habib
authors.forename: D
authors.initials: D
authors.lastname: Behera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D014374:Tuberculin Test; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents