title: Survivin gene polymorphism association with papillary thyroid carcinoma.
abstract: Survivin expression is correlated with suppression of apoptosis in human solid tumors. A polymorphism at position -31 (G/C) (rs 9904341) has been associated with cancer risk in several studies. We evaluated the correlation of this polymorphism with the risk of papillary thyroid carcinoma (PTC) in an Irananian population. The cases consisted of patients with PTC (n=123) and normal controls, composed of non-related healthy people (n=131). The frequency of GC or CC genotype in patients with PTC was significantly higher than in the controls [GC+CC vs GG, p=0.02 OR; 1.7, 95%CI (1.05-3.04)]. There was a significant difference between patients with more aggressive clinical manifestations, including lymphatic involvement compared to the controls [GC+CC vs GG, p=0.0006, OR; 3.7, 95%CI (1.6-9.2)]. The presence of C allele was significantly associated with the presence of more profound manifestations, including lymph node involvement, vascular involvement and multifocality.
authors.affiliation: Otolaryngology and Head & Neck Surgery Research Centre, Tehran University of Medical Sciences, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
authors.forename: Forough A
authors.initials: FA
authors.lastname: Sayahpour
authors.forename: Vahid
authors.initials: V
authors.lastname: Haghpanah
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Maryam
authors.initials: M
authors.lastname: Shahrabi-Farahani
authors.forename: Mehran
authors.initials: M
authors.lastname: Moradi
authors.forename: Arienne
authors.initials: A
authors.lastname: Mirmiran
authors.forename: Mohammad-Taghi
authors.initials: MT
authors.lastname: Khorsandi
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Leila V
authors.initials: LV
authors.lastname: Mostaan
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
mesh_terms: D000328:Adult; D002277:Carcinoma; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D007492:Iran; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D000077022:Survivin; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin