title: Alcoholism and cellular vulnerability in different brain regions.
abstract: Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.
authors.affiliation: Institute of Anatomy and Anthropology, Riga Stradins University, Riga, Latvia. sandra.skuja@gmail.com
authors.forename: Sandra
authors.initials: S
authors.lastname: Skuja
authors.forename: Valerija
authors.initials: V
authors.lastname: Groma
authors.forename: Liene
authors.initials: L
authors.lastname: Smane
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000473:pathology*; D001344:Autopsy; D003342:Corpus Striatum / Q000648:ultrastructure*; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000648:ultrastructure*; D013378:Substantia Nigra / Q000648:ultrastructure*