title: Prenatal diagnosis of a trisomy 7/trisomy 13 mosaicism.
abstract: Double aneuploidy mosaicism of two different aneuploidy cell lines is rare. We describe for the first time a double trisomy mosaicism, involving chromosomes 7 and 13 in a fetus presenting with multiple congenital anomalies. No evidence for chimerism was found by DNA genotyping. The origin of both trisomies are consistent with isodisomy of maternal origin. Therefore, it is most likely that the double trisomy mosaicism arose from two independent events very early in embryonic development. The trisomy 7 and 13 cells were shown to be of maternal origin.
authors.affiliation: Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. k.huijsdens@amc.uva.nl.
authors.forename: Karin
authors.initials: K
authors.lastname: Huijsdens-van Amsterdam
authors.forename: Daniela Qcm
authors.initials: DQ
authors.lastname: Barge-Schaapveld
authors.forename: Inge B
authors.initials: IB
authors.lastname: Mathijssen
authors.forename: Mariëlle
authors.initials: M
authors.lastname: Alders
authors.forename: Eva
authors.initials: E
authors.lastname: Pajkrt
authors.forename: Alida C
authors.initials: AC
authors.lastname: Knegt