title: ADAM33 as a psoriasis susceptibility gene in the Han population of northeastern China.
abstract: BACKGROUND
  A disintegrin and metalloprotease 33 (ADAM33) has recently been suspected to be associated with psoriasis.
  
  
  OBJECTIVE
  To study the association between ADAM33 and psoriasis in the northeastern Chinese Han population.
  
  
  METHODS
  We genotyped six common single nucleotide polymorphisms from ADAM33 in 400 psoriasis cases and 398 controls using the Multiplex SNaPSHOT method.
  
  
  RESULTS
  We observed an increased risk of psoriasis to be associated with the rs2787094CC CG, rs528557CC CG genotypes (p < 0.05) and 3 haplotypes (H1, H3, and H5; p < 0.05). We also found that the rs512625AA rs612709AA GA genotypes and haplotype H8 may be protective against psoriasis (p < 0.05). Among these genotypes, rs2787094CC exhibited the strongest association with psoriasis (OR = 2.537,being the highest OR, p = 0.0014).
  
  
  CONCLUSIONS
  ADAM33 polymorphisms are associated with psoriasis in the northeastern Chinese Han population.
authors.affiliation: Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Donglin
authors.initials: D
authors.lastname: Sun
authors.forename: Lidan
authors.initials: L
authors.lastname: Xu
authors.forename: Liyan
authors.initials: L
authors.lastname: Sun
authors.forename: Songbin
authors.initials: S
authors.lastname: Fu
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Li
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000295:instrumentation / Q000379:methods; D055815:Young Adult
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human