title: Sputum adenosine deaminase and alkaline phosphatase activity in pulmonary tuberculosis.
abstract: OBJECTIVE
  The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis.
  
  
  METHODS
  This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum.
  
  
  RESULTS
  The mean ADA activity in sputum, serum and mean sputum/serum ADA ratio was 205.20 IU/L, 42.32 IU/L and 4.90 in pulmonary tuberculosis and 127.74 IU/L, 29.90 IU/L and 4.27 in lung cancer subjects respectively. The mean ALP activity in sputum, serum and mean sputum/serum ALP ratio was 461.34 IU/L, 159.24 IU/L and 2.90 in pulmonary tuberculosis and 226.64 IU/L, 119.87 IU/L and 1.99 in lung cancer subjects respectively.
  
  
  CONCLUSIONS
  The mean ADA and ALP activity was significantly increased in pulmonary tuberculosis as compared to lung cancer subjects and hence may be a useful tool for the diagnosis of pulmonary tuberculosis.
authors.affiliation: Department of Biochemistry, People's College of Medical Sciences and Research Center, Bhopal, Madhya Pradesh, India. drjadhavaa@yahoo.co.in
authors.forename: Ashish Anantrao
authors.initials: AA
authors.lastname: Jadhav
authors.forename: Anuradha
authors.initials: A
authors.lastname: Jain
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D000077192:Adenocarcinoma of Lung; D000243:Adenosine Deaminase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D013183:Sputum / Q000201:enzymology*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D000469:Alkaline Phosphatase; D000243:Adenosine Deaminase