title: [Effect of polysaccharides on biological activity of human lactoferrin].
abstract: The influence of neutral and ionic polysaccharides on the antioxidant (AOA) and detoxifying activities of lactoferrin (LF) and the duration of its circulation in the body was studied. In addition to natural polymers, we studied artificial chitosan derivatives with different functional groups. On the basis ofAOA test, five polysaccharides were selected. The study of the detoxifying effect of LF in two models of induced toxicity revealed polysaccharides that maintained or increased the detoxifying activity of LF. We established that the formation of a complex of lactoferrin with two galactomannans and succinyl chitosan caused positive changes in LF properties: the detoxifying activity of the protein remained unchanged or increased, whereas its elimination from the body was decelerated.
authors.forename: N M
authors.initials: NM
authors.lastname: Mestechkina
authors.forename: O A
authors.initials: OA
authors.lastname: Bezborodova
authors.forename: A V
authors.initials: AV
authors.lastname: Il'ina
authors.forename: A N
authors.initials: AN
authors.lastname: Levov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Kleĭmenov
authors.forename: E R
authors.initials: ER
authors.lastname: Nemtsova
authors.forename: R I
authors.initials: RI
authors.lastname: Iakubovskaia
authors.forename: V D
authors.initials: VD
authors.lastname: Shcherbukhin
authors.forename: V P
authors.initials: VP
authors.lastname: Varlamov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002152:Calorimetry, Differential Scanning; D002251:Carbon Tetrachloride / Q000633:toxicity; D048271:Chitosan / Q000008:administration & dosage*; D002945:Cisplatin / Q000633:toxicity; D003911:Dextrans / Q000008:administration & dosage; D004357:Drug Synergism; D005685:Galactans / Q000008:administration & dosage; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D007781:Lactoferrin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008351:Mannans / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000975:Antioxidants; D003911:Dextrans; D005685:Galactans; D008351:Mannans; C012990:galactomannan; C022901:(1-6)-alpha-glucomannan; D048271:Chitosan; D002251:Carbon Tetrachloride; D007781:Lactoferrin; D002945:Cisplatin; C005653:arabinogalactan; D005690:Galactose