title: VAMP-8 gene variant is associated with increased risk of early myocardial infarction.
abstract: BACKGROUND
  Single nucleotide polymorphism in the 3' untranslated region of the vesicle-associated membrane protein gene (VAMP-8) has been associated with increased risk of early-onset myocardial infarction (MI). In this study the risk of early onset MI conferred by VAMP-8 gene polymorphism was investigated in a group of 171 male subjects.
  
  
  METHODS
  Male patients with a history of MI who underwent coronary angiography were enrolled and divided into early (incident < 55 years of age) and late (incident ≥ 55 years of age) MI onset groups. Apart from the RFLP-PCR based analysis of the VAMP-8 variant, history of hypertension, lipid abnormalities, smoking and body mass index were recorded. In statistical analyses odds ratios and relative risk were used as a measure of genotype-MI association while logistic regression was implemented for evaluation of MI risk factor strength.
  
  
  RESULTS
  VAMP-8 A allele frequency proved to be significantly higher in the early-onset MI group and conferred higher relative risk of early MI in the investigated cohort, when calculated for the individual A allele (p = 0.029). In logistic regression analyses no association between risk genotypes and traditional risk factors was observed.
  
  
  CONCLUSIONS
  In this study VAMP-8 A variant was identified as a risk allele for early MI in male subjects.
authors.affiliation: Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Gorący
authors.forename: Iwona
authors.initials: I
authors.lastname: Gorący
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kaczmarczyk
authors.forename: Miłosz
authors.initials: M
authors.lastname: Parczewski
authors.forename: Lech
authors.initials: L
authors.lastname: Cyryłowski
authors.forename: Mirosław
authors.initials: M
authors.lastname: Brykczyński
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Peregud-Pogorzelska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz