title: The Jak/STAT pathway is involved in synaptic plasticity.
abstract: The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.
authors.affiliation: MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK.
authors.forename: Céline S
authors.initials: CS
authors.lastname: Nicolas
authors.forename: Stéphane
authors.initials: S
authors.lastname: Peineau
authors.forename: Mascia
authors.initials: M
authors.lastname: Amici
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Csaba
authors.forename: Assia
authors.initials: A
authors.lastname: Fafouri
authors.forename: Charlotte
authors.initials: C
authors.lastname: Javalet
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Collett
authors.forename: Lars
authors.initials: L
authors.lastname: Hildebrandt
authors.forename: Gillian
authors.initials: G
authors.lastname: Seaton
authors.forename: Sun-Lim
authors.initials: SL
authors.lastname: Choi
authors.forename: Su-Eon
authors.initials: SE
authors.lastname: Sim
authors.forename: Clarrisa
authors.initials: C
authors.lastname: Bradley
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
authors.forename: Pascal
authors.initials: P
authors.lastname: Dournaud
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Fitzjohn
authors.forename: Zuner A
authors.initials: ZA
authors.lastname: Bortolotto
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
authors.forename: Graham L
authors.initials: GL
authors.lastname: Collingridge
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D053612:Janus Kinases / Q000378:metabolism*; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects / Q000502:physiology; D051381:Rats; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D020032:Tyrphostins / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D050791:STAT Transcription Factors; D020032:Tyrphostins; C095512:alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; D053612:Janus Kinases