title: Protein kinases as targets for interventive biogerontology: overview and perspectives.
abstract: Protein kinases are enzymes that catalyze the transfer of γ phosphate from adenosine triphosphate to substrate proteins, and are important signal transduction mediators in a diversity of biological processes, ranging from apoptosis to energy metabolism. In this article, we will take this prominent class of proteins as an example to illustrate the involvement of proteins in modulation of aging and to highlight the prospects and challenges of protein-targeted interventions for anti-aging purposes. It is hoped that through this article, more empirical work on interventive gerontology will follow, and with collaborative endeavors among researchers, hurdles in anti-aging intervention development can be overcome in the near future.
authors.affiliation: Department of Biochemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China. rori0610@graduate.hku.hk
authors.forename: Wing-Fu
authors.initials: WF
authors.lastname: Lai
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D005853:Geriatrics / Q000639:trends; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases