title: Detection of colorectal tumors with water enema-multidetector row computed tomography.
abstract: OBJECTIVE
  To retrospectively determine the diagnostic capabilities of water enema-multidetector row computed tomography (WE-MDCT) in the detection of colorectal tumors.
  
  
  METHODS
  One hundred and one patients (55 male, 46 female) who had WE-MDCT and videocolonoscopy because of suspected colorectal tumors were included. Results of complete videocolonoscopy, surgery, and histopathologic analysis were used as standard of reference. Sensitivity, specificity, and accuracy, and positive and negative predictive values of WE-MDCT for the diagnosis of colorectal tumors were estimated with 95% confidence intervals (CIs).
  
  
  RESULTS
  Ninety-two colorectal tumors (64 malignant, 28 benign) were confirmed in 71 patients (prevalence, 71/101; 70%). Overall sensitivity for colorectal tumor detection was 87% (80/92; 95%CI: 78%-93%) on a per lesion basis. For malignant and benign tumor detection, sensitivity was 100% (64/64; 95%CI: 94%-100%) and 57% (16/28; 95%CI: 37%-76%), respectively. For colorectal tumors ≥10 mm, sensitivity was 99% (76/77; 95%CI: 93%-100%). Seventy-nine of the 83 colorectal tumors ≥6 mm were detected, yielding a sensitivity of 95% (79/83; 95%CI: 88%-99%) for this specific size category. On a per patient basis, WE-MDCT had a sensitivity of 100% (71/71; 95%CI: 94%-100%), a specificity of 100% (30/30; 95%CI: 88%-100%), an accuracy of 100% (101/101; 95%CI: 96%-100%), a positive predictive value of 100% (71/71; 95%CI: 94%-100%), and a negative predictive value of 100% (30/30; 95%CI: 86%-100%) for the diagnosis of colorectal tumor.
  
  
  CONCLUSIONS
  Our results suggest that WE-MDCT is a promising imaging technique for the detection of malignant colorectal tumors. However, our results should be validated by larger and prospective studies.
authors.affiliation: Department of Abdominal Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. philippe.soyer@lrb.aphp.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Soyer
authors.forename: Marc
authors.initials: M
authors.lastname: Sirol
authors.forename: Xavier
authors.initials: X
authors.lastname: Dray
authors.forename: Vinciane
authors.initials: V
authors.lastname: Placé
authors.forename: Karine
authors.initials: K
authors.lastname: Pautrat
authors.forename: Lounis
authors.initials: L
authors.lastname: Hamzi
authors.forename: Mourad
authors.initials: M
authors.lastname: Boudiaf
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D018253:Adenoma, Villous / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D004733:Enema / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014741:Video Recording; D014867:Water
chemical_list: D014867:Water