title: Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity.
abstract: We report here the noncovalent synthesis of thermosensitive dendrimers. Short oligoguanosine strands were linked to the focal point of a dendron by using "click chemistry", and quadruplex formation was used to drive the self-assembly process in the presence of metal ions. The dynamic nature of these noncovalent assemblies can be exploited to create combinatorial libraries of dendrimers as demonstrated by the co-assembly of two components. These supramolecular dendrimers showed thermoresponsive behavior that can be tuned by varying the templating cations or the number of guanines in the oligonucleotide strand.
authors.affiliation: Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.
authors.forename: Partha S
authors.initials: PS
authors.lastname: Ghosh
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D020650:Combinatorial Chemistry Techniques; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D006151:Guanosine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013697:Thermosensing
chemical_list: D050091:Dendrimers; D006151:Guanosine