title: Intensified ChlVPP/ABVVP chemotherapy regimen and pegfilgrastim support in advanced Hodgkin lymphoma.
abstract: We present feasibility, toxicity and efficacy results of an intensified six-cycle ChlVPP/ABVVP regimen in advanced Hodgkin lymphoma (HL). From February 2004 to August 2007, 82 consecutive eligible patients were enrolled. According to the Hasenclever index, 64 patients (78%) were considered at low risk, 15 (18%) at intermediate and 3 (4%) at high risk. The most relevant toxicity was haematological: grade 3-4 neutropenia occurred in 32% of patients, grade 3-4 anaemia in 26% of patients. Severe infections and febrile neutropenia were observed in 8% of patients. With a median follow-up of 35 months (range 12-55), the three-year freedom from treatment failure (FFTF) and overall survival (OS) were 75% (95% CI 65%-86%) and 94% (95% CI 87%-99%), respectively. The intensified ChlVPP/ABVVP regimen in advanced HL is effective, does not seem to differ from standard regimens in terms of FFTF and OS and showed a favourable toxicity profile.
authors.affiliation: Haematoncology Division.
authors.forename: E
authors.initials: E
authors.lastname: Cocorocchio
authors.forename: A
authors.initials: A
authors.lastname: Vanazzi
authors.forename: S
authors.initials: S
authors.lastname: Bassi
authors.forename: F
authors.initials: F
authors.lastname: Peccatori
authors.forename: P
authors.initials: P
authors.lastname: Antoniotti
authors.forename: F
authors.initials: F
authors.lastname: Gigli
authors.forename: L
authors.initials: L
authors.lastname: Travaini
authors.forename: G
authors.initials: G
authors.lastname: Piperno
authors.forename: G
authors.initials: G
authors.lastname: Pruneri
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authors.initials: L
authors.lastname: Preda
authors.forename: R
authors.initials: R
authors.lastname: Biffi
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authors.lastname: Botteri
authors.forename: M
authors.initials: M
authors.lastname: Negri
authors.forename: G
authors.initials: G
authors.lastname: Martinelli