title: Phytotoxicity of lignanamides isolated from the seeds of Hyoscyamus niger.
abstract: Bioassay-guided fractionation of phytotoxic extracts prepared from the seeds of  Hyoscyamus niger  led to the isolation of three new lignanamides (1-3), along with six known lignanamides (4-9). The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance techniques, and high-resolution electrospray ionization mass spectrometry. The bioactivity analysis of the isolated compounds showed that compound 3 exhibited significant inhibition on the germination and radical elongation of  Allium fistulosum  at 10(-4) M concentration.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
authors.forename: Wen-Na
authors.initials: WN
authors.lastname: Zhang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000490:Allium / Q000187:drug effects / Q000254:growth & development; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000302:isolation & purification / Q000494:pharmacology*; D032304:Hyoscyamus / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry* / Q000254:growth & development
chemical_list: D006540:Herbicides; D017705:Lignans; D010936:Plant Extracts