title: Extensively drug-resistant tuberculosis: experience at the Tuberculosis Research Centre, Chennai, India.
abstract: Ten extensively drug-resistant tuberculosis (XDR-TB) patients were identified among 104 human immunodeficiency virus negative multidrug-resistant tuberculosis (MDR-TB) patients treated at the Tuberculosis Research Centre, Chennai, India, in two different cohorts between 1999-2003 and 2006-2007. They were managed with individualised treatment regimens. At the time of diagnosis of MDR-TB, one patient had XDR-TB and three had initial ofloxacin resistance. One patient who had had a lobectomy in addition to chemotherapy became bacteriologically negative, three died, three defaulted and the remaining three, who are bacteriologically positive, are still continuing treatment. Although based on a small number of patients, our results have not been encouraging.
authors.affiliation: Tuberculosis Research Centre (Indian Council of Medical Research), Chennai, India. aleyamma_01@yahoo.co.in
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: P
authors.initials: P
authors.lastname: Joseph
authors.forename: D
authors.initials: D
authors.lastname: Nair
authors.forename: D V B
authors.initials: DV
authors.lastname: Rao
authors.forename: V V B
authors.initials: VV
authors.lastname: Rekha
authors.forename: N
authors.initials: N
authors.lastname: Selvakumar
authors.forename: K
authors.initials: K
authors.lastname: Jaggarajamma
authors.forename: R
authors.initials: R
authors.lastname: Balambal
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D055118:Medication Adherence; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011013:Pneumonectomy; D012189:Retrospective Studies; D013812:Therapeutics; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality
chemical_list: D000995:Antitubercular Agents