title: Neuroprotector effect of comenic acid against cytotoxic action of glutamate in vitro in cultured neurons of lead-poisoned rat pups.
abstract: We demonstrated an increase in glutamate neurocytotoxicity in cultured cerebellar cells from rat pups subjected to lead poisoning during the prenatal development or early lactation period. The toxic effect of glutamate was weaker, if lead was applied in combination with antioxidant comenic acid. These data are discussed in view of practical use of comenic acid for the therapy of the brain tissues subjected to lead poisoning.
authors.affiliation: Kuban State University, Krasnodar, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Kravtsov
authors.forename: A Ya
authors.initials: AY
authors.lastname: Shurygin
authors.forename: N S
authors.initials: NS
authors.lastname: Skorokhod
authors.forename: L G
authors.initials: LG
authors.lastname: Khaspekov
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002264:Carboxylic Acids / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D005971:Glutamates / Q000633:toxicity*; D020263:Lead Poisoning, Nervous System / Q000188:drug therapy*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002264:Carboxylic Acids; D005971:Glutamates; D018696:Neuroprotective Agents; D011753:Pyrones; C488376:comenic acid