title: Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia.
abstract: The treatment of schizophrenia has been focused on modulation of dopamine receptors for over 50 years. Recent developments have implicated other neurotransmitter systems in the pathophysiology of this illness. The discovery and characterization of glutamate receptors and their roles in the brain has lead to novel approaches for the treatment of schizophrenia. In this article, we review drugs that modulate ionotropic gluamate receptors and discuss their efficacy for the treatment of this often debilitating severe mental illness.
authors.affiliation: Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: McCullumsmith
authors.forename: John
authors.initials: J
authors.lastname: Hammond
authors.forename: Adam
authors.initials: A
authors.lastname: Funk
authors.forename: James H
authors.initials: JH
authors.lastname: Meador-Woodruff
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D058468:Receptors, Ionotropic Glutamate / Q000502:physiology*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D058468:Receptors, Ionotropic Glutamate; D018698:Glutamic Acid