title: Contribution of HOGG1 Ser³²⁶Cys polymorphism to the development of prostate cancer in smokers: meta-analysis of 2779 cases and 3484 controls.
abstract: The HOGG1 gene catalyzes the excision of modified bases and removal of DNA damage adducts. It may play an important role in the prevention of carcinogenesis. Ser³²⁶Cys polymorphism localizes in exon 7 of the hOGG1 gene. It takes the form of an amino acid substitution, from serine to cysteine, in codon 326. Several epidemiological association studies have been conducted on this polymorphism and its relationship with the risk of prostate cancer. However, results have been conflicting. To resolve this conflict, we conducted a meta-analysis on the association between this polymorphism and prostate cancer, taking into account race, country, sources of controls, and smoking status. A total of nine studies covering 2779 cases and 3484 controls were included in the current meta-analysis. Although no significant association was found between hOGG1 Ser³²⁶Cys polymorphism and prostate cancer susceptibility in the pooled analysis, individuals with Ser/Cys+Cys/Cys genotypes were found to have greater risk of prostate cancer if they were also smokers (OR = 2.66, 95% CI = 1.58-4.47) rather than non-smokers (OR = 2.18, 95% CI = 1.13-4.19), compared with those with Ser/Ser genotype. In conclusion, our meta-analysis demonstrates that hOGG1 Ser³²⁶Cys polymorphism is a risk factor for prostate cancer in smokers. Further studies are needed to confirm this relationship.
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Shu-Qiu
authors.initials: SQ
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Xiang-Nong
authors.initials: XN
authors.lastname: Hu
authors.forename: Guo-Zhu
authors.initials: GZ
authors.lastname: Sha
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
mesh_terms: D019943:Amino Acid Substitution; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human