title: Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits.
abstract: OBJECTIVE
  To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits.
  
  
  METHODS
  We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In  group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps.
  
  
  RESULTS
  The Na+-K+ATPase activity increased after DFO treatment (p=0.045).
  
  
  CONCLUSIONS
  We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.
authors.affiliation: Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: gurbil@yahoo.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gurbilek
authors.forename: Cemile
authors.initials: C
authors.lastname: Topcu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akoz
authors.forename: Hulagu
authors.initials: H
authors.lastname: Bariskaner
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Ustun
authors.forename: Oznur
authors.initials: O
authors.lastname: Koylu