title: Liver microsome-mediated mutagenicity of dihydrodiols derived from dibenz(a,c)anthracene in S. typhimurium TA100.
abstract: The mutagenic activities of the trans-1,2- and 3,4-diols of dibenz(a,c)anthracene, both of which could yield 'bay-region' diol-epoxides on further metabolism, were lower than those of the parent hydrocarbon and of the related 10,11-diol.
authors.affiliation: International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Malaveille
authors.forename: A
authors.initials: A
authors.lastname: Hautefeuille
authors.forename: H
authors.initials: H
authors.lastname: Bartsch
authors.forename: A D
authors.initials: AD
authors.lastname: MacNicoll
authors.forename: P L
authors.initials: PL
authors.lastname: Grover
authors.forename: P
authors.initials: P
authors.lastname: Sims
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D004101:Dihydroxydihydrobenzopyrenes / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D001551:Benz(a)Anthracenes; D004101:Dihydroxydihydrobenzopyrenes; C021627:benzanthracene-10,11-dihydrodiol; C031197:3,4-dihydro-3,4-dihydroxybenzo(a,i)pyrene; C031196:1,2-dihydro-1,2-dihydroxydibenzo(a)pyrene