title: Pegylated liposomal doxorubicin (PLD): enhanced skin toxicity in areas of vitiligo.
abstract: Pegylated liposomal doxorubicin (PLD, Doxil, Caelyx) is widely used for the treatment of ovarian cancer. It is a stable formulation encapsulating doxorubicin in a 'Stealth' (i.e., pegylated) liposome with a half-life of about 72 hours. This drastically altered pharmacology confers on it a considerably lower risk of cardiotoxicity, no acute emesis, and near absence of alopecia or problems with extravasation necrosis. On the other hand, PLD's dose-limiting toxicity is cutaneous. Since the original phase I report, cutaneous toxicities reported with PLD fall into four common categories: the well known hand-foot syndrome (also called palmoplantar erythrodysesthesia, or PPE), a diffuse follicular rash, intertrigo-like eruption, and hyperpigmentation including melanotic macules.
authors.affiliation: NYU Cancer Institute and Medical Oncology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
authors.forename: S J
authors.initials: SJ
authors.lastname: Orlow
authors.forename: J
authors.initials: J
authors.lastname: Curtin
authors.forename: A
authors.initials: A
authors.lastname: Downey
authors.forename: F
authors.initials: F
authors.lastname: Muggia