title: Viral infections detected by serology and PCR of perilymphatic fluid in children with idiopathic sensorineural hearing loss.
abstract: The etiology of sensorineural hearing loss (SNHL) in children may be viral. This cross-sectional study aimed to determine the role of viral infectious agents in children with idiopathic SNHL. Of 119 children with SNHL aged 3-168 months undergoing cochlear implant surgery at a hospital in Tehran, no cause could be established in 18 cases (15.1%). Cytomegalovirus (CMV) and herpes simplex virus (HSV) active infections (detected by DNA-PCR, confirmed by serology) were found in the perilymphatic fluid of 16.7% (3/18) cases of idiopathic SNHL. Serology was performed on blood samples from 11 of these cases: specific antibodies against CMV, Toxoplasma spp., HSV and rubella were determined in all cases; acute T. gondii infection was detected in 7 cases and rubella IgG was found in only 1 case. Neonatal screening for CMV, HSV and T gondii may be helpful in the Islamic Republi of Iran.
authors.affiliation: Paediatric Infectious Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Samileh_noorbakhsh@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Noorbakhsh
authors.forename: M
authors.initials: M
authors.lastname: Farhadi
authors.forename: A
authors.initials: A
authors.lastname: Daneshi
authors.forename: S
authors.initials: S
authors.lastname: Mohamadi
authors.forename: A
authors.initials: A
authors.lastname: Tabatabaei
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D016054:DNA, Protozoan / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000821:virology; D006561:Herpes Simplex / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D010498:Perilymph / Q000821:virology*; D016133:Polymerase Chain Reaction; D012698:Serologic Tests; D014123:Toxoplasmosis / Q000175:diagnosis
chemical_list: D016054:DNA, Protozoan; D004279:DNA, Viral