title: In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii.
abstract: OBJECTIVE
  The activity of BAL30072 was compared with that of anti-Acinetobacter reference drugs against meropenem-non-susceptible Acinetobacter baumannii isolates associated with up-regulation of the intrinsic OXA-51-like enzyme or an acquired OXA.
  
  
  METHODS
  Antimicrobial susceptibility testing was investigated by broth microdilution of 310 non-duplicate, meropenem-non-susceptible A. baumannii isolates to BAL30072, amikacin ampicillin/sulbactam, aztreonam, cefepime, colistin, imipenem, levofloxacin, meropenem, rifampicin, tigecycline and tobramycin.
  
  
  RESULTS
  BAL30072 showed greater activity than the β-lactam comparators, levofloxacin, amikacin, tobramycin and rifampicin. The activity of BAL30072 was comparable to that of tigecycline, with an MIC(50) of 2 mg/L. Elevated BAL30072 MICs were found, but there was no correlation with elevated MICs of the other antimicrobials.
  
  
  CONCLUSIONS
  BAL30072 is a promising new agent with good activity against carbapenem-non-susceptible A. baumannii.
authors.affiliation: Institute for Medical Microbiology, Immunology and Hygiene,  University of Cologne, Cologne,  Germany.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Higgins
authors.forename: Danuta
authors.initials: D
authors.lastname: Stefanik
authors.forename: Malcolm G P
authors.initials: MG
authors.lastname: Page
authors.forename: Meredith
authors.initials: M
authors.lastname: Hackel
authors.forename: Harald
authors.initials: H
authors.lastname: Seifert
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; C552042:BAL 30072; D008997:Monobactams; D013844:Thiazoles; D013845:Thienamycins; D001618:beta-Lactamases; D000077731:Meropenem