title: Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48.
abstract: Bioassay-guided fractionation of the culture extract of Aspergillus wentii EN-48, an endophytic fungus isolated from an unidentified marine brown algal species of the genus Sargassum, led to the isolation of three new tetranorlabdane diterpenoids, asperolides A-C (1-3), and five related derivatives (4-8). The structures of these compounds were established on the basis of spectroscopic interpretation, and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 1 was determined by application of the modified Mosher's method. An X-ray structure for wentilactone B (6) is also reported. Compounds 1-8 were evaluated for cytotoxic and antibacterial activities.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors.forename: Hao-Fen
authors.initials: HF
authors.lastname: Sun
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Meng
authors.forename: Chuan-Ming
authors.initials: CM
authors.lastname: Cui
authors.forename: Shu-Shan
authors.initials: SS
authors.lastname: Gao
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Cai-Guo
authors.initials: CG
authors.lastname: Huang
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C571435:asperolide A; C571436:asperolide B; C571437:asperolide C; D000667:Ampicillin