title: Hyperpolarized 129Xe gas lung MRI-SNR and T2* comparisons at 1.5 T and 3 T.
abstract: In this study, the signal-to-noise ratio of hyperpolarized (129)Xe human lung magnetic resonance imaging was compared at 1.5 T and 3 T. Experiments were performed at both B(0) fields with quadrature double Helmholtz transmit-receive chest coils of the same geometry with the same subject loads. Differences in sensitivity between the two field strengths were assessed from the signal-to-noise ratio of multi-slice 2D (129)Xe ventilation lung images obtained at the two field strengths with a spatial resolution of 15 mm × 4 mm × 4 mm. There was a systematically higher signal-to-noise ratio observed at 3 T than at 1.5 T by a factor of 1.25. Mean image signal-to-noise ratio was in the range 27-44 at 1.5 T and 36-51 at 3 T. T 2* of (129)Xe gas in the partially inflated lungs was measured to be 25 ms and 18 ms at 1.5 T and 3 T, respectively. T 2* of (129)Xe gas in fully inflated lungs was measured to be 52 ms and 24 ms at 1.5 T and 3 T, respectively.
authors.affiliation: Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xu
authors.forename: Graham
authors.initials: G
authors.lastname: Norquay
authors.forename: Steven R
authors.initials: SR
authors.lastname: Parnell
authors.forename: Martin H
authors.initials: MH
authors.lastname: Deppe
authors.forename: Salma
authors.initials: S
authors.lastname: Ajraoui
authors.forename: Ralph
authors.initials: R
authors.lastname: Hashoian
authors.forename: Helen
authors.initials: H
authors.lastname: Marshall
authors.forename: Paul D
authors.initials: PD
authors.lastname: Griffiths
authors.forename: Juan
authors.initials: J
authors.lastname: Parra-Robles
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005740:Gases / Q000008:administration & dosage; D006801:Humans; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio; D014979:Xenon Isotopes / Q000008:administration & dosage*
chemical_list: D003287:Contrast Media; D005740:Gases; D019275:Radiopharmaceuticals; D014979:Xenon Isotopes