title: Association of Helicobacter pylori infection with microalbuminuria in type 2 diabetic patients.
abstract: OBJECTIVE
  As default, Helicobacter pylori infection may cause systemic inflammation and vascular endothelial damage. Therefore, it can be assumed that the glomerular damage as a result may lead to an increase in urinary albumin excretion. In this study, this hypothesis was set, and the relationship between Helicobacter pylori infection and microalbuminuria was examined.
  
  
  METHODS
  Ninety-three patients with type 2 diabetes were included in the study. These patients were divided into two groups as Helicobacter pylori infection-positive (Group 1) or -negative (Group 2). In all infected and non-infected patients, urinary albumin excretion and other parameters were compared.
  
  
  RESULTS
  The presence of Helicobacter pylori infection was detected in 53 of 93 diabetic patients (56.98%). Diabetic patients infected by Helicobacter pylori (Group 1; 186.7±24.2 mg/24 h) showed significantly higher microalbuminuria than non-infected patients (Group 2; 131.2±11.6 mg/24 h) (p=0.012). Diabetics infected with Helicobacter pylori had significantly higher inflammation marker levels than non-infected patients (p<0.05). It has been concluded that the relation between microalbuminuria level and Helicobacter pylori infection in diabetics is independent from other study variables.
  
  
  CONCLUSIONS
  Helicobacter pylori infection, because of the systemic inflammatory response, may play an important role in the progression of diabetic nephropathy or its development. In this study, demonstrating the relationship between Helicobacter pylori infection with diabetic microalbuminuria, due to the small number of patients, is inadequate. Therefore, clinical and molecular studies involving more patients should be supported.
authors.affiliation: Department of Internal Medicine, Palu Government Hospital, Elazığ. ozgurtanriverdi@hotmail.com
authors.forename: Ozgür
authors.initials: O
authors.lastname: Tanriverdı
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000652:urine*; D003928:Diabetic Nephropathies / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000652:urine*; D016480:Helicobacter pylori; D006801:Humans; D007958:Leukocyte Count; D017270:Lipoprotein(a) / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D018709:Statistics, Nonparametric
chemical_list: D017270:Lipoprotein(a); D005340:Fibrinogen; D002097:C-Reactive Protein