title: [Application of nested case-control study on safe evaluation of post-marketing traditional Chinese medicine injection].
abstract: The nested case-control study design (or the case-control in a cohort study) is described here as a new study design used in safe evaluation of post-marketing traditional Chinese medicine injection. In the nested case-control study, cases of a disease that occur in a defined cohort are identified and, for each, a specified number of matched controls is selected from among those in the cohort who have not developed the disease by the time of disease occurrence in the case. For many research questions, the nested case-control design potentially offers impressive reductions in costs and efforts of data collection and analysis compared with the full cohort approach, with relatively minor loss in statistical efficiency. The nested case-control design is particularly advantageous for studies in safe evaluation of post-marketing traditional Chinese medicine injection. Some examples of the application of nested case-control study were given.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. yingxiao629@163.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yubin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xie
mesh_terms: D016022:Case-Control Studies; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007267:Injections; D008516:Medicine, Chinese Traditional / Q000009:adverse effects*; D011358:Product Surveillance, Postmarketing