title: Efficacy of 90Y ibritumomab-tiuxetan treatment in a case of resistant gastric MALT non-Hodgkin's lymphoma.
abstract: Treatment modalities for resistant/relapsing gastric mucosa associated lymphoid tissue (MALT) non-Hodgkin's lymphoma (NHL) are not yet well standardized. In the past, most patients were treated surgically with a gastrectomy, while, more recently, radiotherapy and systemic approaches (chemotherapy and immunotherapy) have been used with improving results.Here, we report the case of a patient affected by MALT NHL resistant to antibiotics, chemotherapy and immunotherapy, who achieved a durable complete remission after radio-immunotherapy treatment with Zevalin ((90)Y ibritumomab-tiuxetan), administered in a single-standard dose. This observation must be confirmed on a larger series but suggests that radio-immunotherapy may be a valid approach in treating relapsing MALT NHL patients, or those resistant to conventional therapies, so avoiding more aggressive and toxic approaches.
authors.affiliation: Hematoncology Division, European Institute of Oncology, Via Ripamonti 435, 20100 Milan, Italy.
authors.forename: P F
authors.initials: PF
authors.lastname: Ferrucci
authors.forename: A
authors.initials: A
authors.lastname: Vanazzi
authors.forename: C
authors.initials: C
authors.lastname: Crosta
authors.forename: G
authors.initials: G
authors.lastname: Pruneri
authors.forename: C
authors.initials: C
authors.lastname: Grana
authors.forename: M
authors.initials: M
authors.lastname: Bartolomei
authors.forename: G
authors.initials: G
authors.lastname: Paganelli
authors.forename: G
authors.initials: G
authors.lastname: Martinelli