title: Renal leishmaniasis as unusual cause of nephrotic syndrome in an HIV patient.
abstract: Renal involvement is a rare complication in HIV-1-infected patients leading to various pathologies and clinical symptoms. In addition to the classic HIV-1-associated nephropathy with collapsing-type focal segmental glomerulosclerosis and characteristic tubulocystic changes, which is more common in Afro-American than in Caucasian HIV-1 patients, immune complex GNs such as membranous GN and membranoproliferative GN are particularly common renal manifestations. Besides HIV-1 itself, a number of opportunistic infections may cause renal disease in HIV-1-infected patients. In this study, we report an unusual case of HIV-1 infection with a severe renal manifestation of systemic leishmaniasis that developed years after repeated visits to Mediterranean countries. The case presents several remarkable clinical, pathologic, and therapeutic aspects that may be important for daily clinical practice.
authors.affiliation: Abt. für Nephropathologie, Pathologisches Institut, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. kerstin.amann@uk-erlangen.de
authors.forename: Kerstin
authors.initials: K
authors.lastname: Amann
authors.forename: Christian
authors.initials: C
authors.lastname: Bogdan
authors.forename: Thomas
authors.initials: T
authors.lastname: Harrer
authors.forename: Juergen
authors.initials: J
authors.lastname: Rech
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000469:parasitology* / Q000473:pathology; D007677:Kidney Function Tests; D007896:Leishmaniasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000469:parasitology / Q000628:therapy; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D000666:Amphotericin B