title: Dermal mast cells affect the development of sunlight-induced skin tumours.
abstract: Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerging that UV may also trigger mast cell release of cutaneous tissue remodelling and pro-angiogenic factors. In this review, we will focus on the cellular and molecular mechanisms by which UV recruits and then activates mast cells to initiate and promote skin cancer development.
authors.affiliation: Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Seri N E
authors.initials: SN
authors.lastname: Sarchio
authors.forename: Lai-Fong
authors.initials: LF
authors.lastname: Kok
authors.forename: Clare
authors.initials: C
authors.lastname: O'Sullivan
authors.forename: Gary M
authors.initials: GM
authors.lastname: Halliday
authors.forename: Scott N
authors.initials: SN
authors.lastname: Byrne
mesh_terms: D000818:Animals; D006632:Histamine / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000528:radiation effects; D016753:Interleukin-10 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology / Q000502:physiology / Q000528:radiation effects*; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D020932:Nerve Growth Factor / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D013472:Sunlight / Q000009:adverse effects*; D016212:Transforming Growth Factor beta / Q000502:physiology; D059016:Tumor Microenvironment / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014466:Ultraviolet Rays / Q000009:adverse effects; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: C508609:IL10 protein, human; C508598:IL4 protein, human; D009479:Neuropeptides; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10; D015847:Interleukin-4; D006632:Histamine; D020932:Nerve Growth Factor