title: [Radiation-induced "bystander effect" revealed by means of adaptive response in cocultured lymphocytes from humans of different genders].
abstract: The "bystander effect" was investigated in mixed cultures of lymphocytes from humans of opposite genders. Development of the adaptive response (AR) in non-irradiated female/male cells was estimated after adaptive pretreatment of opposite gender lymphocytes, chromosome aberrations being evaluated. Experiments were performed using two schedules of adaptive (0.05 Gy) and challenging (1 Gy) irradiations: G0-G1 and G1-G1. The results obtained indicate the development of a mediated adaptive response ("bystander effect") in the lymphocytes neighboring pre-irradiated cells, as well as the influence of a time scheme of adapting and challenging irradiations on the amount of induced chromosome aberrations in mixed cultures and a possible dependence of the adaptive response intensity on the donor gender.
authors.forename: I S
authors.initials: IS
authors.lastname: Kolesnikova
authors.forename: I E
authors.initials: IE
authors.lastname: Vorobtsova
mesh_terms: D000222:Adaptation, Physiological / Q000528:radiation effects*; D024201:Bystander Effect / Q000528:radiation effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000528:radiation effects; D018920:Coculture Techniques; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D012727:Sex Characteristics; D013997:Time Factors