title: Individual differences in skilled adult readers reveal dissociable patterns of neural activity associated with component processes of reading.
abstract: We used fMRI to examine patterns of brain activity associated with component processes of visual word recognition and their relationships to individual differences in reading skill. We manipulated both the judgments adults made on written stimuli and the characteristics of the stimuli. Phonological processing led to activation in left inferior frontal and temporal regions whereas semantic processing was associated with bilateral middle frontal activation. Individual differences in reading subskills were reflected in differences in the degree to which cortical regions were engaged during reading. Variation in sight word reading efficiency was associated with degree of activation in visual cortex. Increased phonological decoding skill was associated with greater activation in left temporo-parietal cortex. Greater reading comprehension ability was associated with decreased activation in anterior cingulate and temporal regions. Notably, associations between reading ability and neural activation indicate that brain/behavior relationships among skilled readers differ from patterns associated with dyslexia and reading development.
authors.affiliation: The Brain and Mind Institute, The University of Western Ontario, London, Ontario, Canada N6A 5B7. swelcome@uwo.ca
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Welcome
authors.forename: Marc F
authors.initials: MF
authors.lastname: Joanisse
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004410:Dyslexia / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007600:Judgment / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011932:Reading; D012016:Reference Values; D013702:Temporal Lobe / Q000502:physiology; D055815:Young Adult