title: Lanostane triterpenoids from the stems of Schisandra glaucescens.
abstract: Ten new triterpenoids, schiglausins A-J (1-10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Diao
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D014315:Triterpenes