title: Direct comparison of measured and calculated total knee replacement force envelopes during walking in the presence of normal and abnormal gait patterns.
abstract: Knee joint forces measured from instrumented implants provide important information for testing the validity of computational models that predict knee joint forces. The purpose of this study was to validate a parametric numerical model for predicting knee joint contact forces against measurements from four subjects with instrumented TKRs during the stance phase of gait. Model sensitivity to abnormal gait patterns was also investigated. The results demonstrated good agreement for three subjects with relatively normal gait patterns, where the difference between the mean measured and calculated forces ranged from 0.05 to 0.45 body weights, and the envelopes of measured and calculated forces (from three walking trials) overlapped. The fourth subject, who had a "quadriceps avoidance" external moment pattern, initially had little overlap between the measured and calculated force envelopes. When additional constraints were added, tailored to the subject's gait pattern, the model predictions improved to complete force envelope overlap. Coefficient of multiple determination analysis indicated that the shape of the measured and calculated force waveforms were similar for all subjects (adjusted coefficient of multiple correlation values between 0.88 and 0.92). The parametric model was accurate in predicting both the magnitude and waveform of the contact force, and the accuracy of model predictions was affected by deviations from normal gait patterns. Equally important, the envelope of forces generated by the range of solutions substantially overlapped with the corresponding measured envelope from multiple gait trials for a given subject, suggesting that the variable strategic processes of in vivo force generation are covered by the solution range of this parametric model.
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Lundberg
authors.forename: Kharma C
authors.initials: KC
authors.lastname: Foucher
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Andriacchi
authors.forename: Markus A
authors.initials: MA
authors.lastname: Wimmer
mesh_terms: D000368:Aged; D005260:Female; D005684:Gait; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D016474:Weight-Bearing