title: Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy.
abstract: Drug transporters mediate the movement of endobiotics and xenobiotics across biological membranes in multiple organs and in most tissues. As such, they are involved in physiology, development of disease, drug pharmacokinetics, and ultimately the clinical response to a myriad of medications. Genetic variants in transporters cause population-specific differences in drug transport and are responsible for considerable inter-individual variation in physiology and pharmacotherapy. The purpose of this review is to provide a broad overview of how inherited variants in transporters are associated with disease etiology, disease state, and the pharmacological treatment of diseases. Given that there are thousands of published papers related to the interplay between transporter genetics and medicine, this review will provide examples that exemplify the broader focus of the literature.
authors.affiliation: Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Tristan M
authors.initials: TM
authors.lastname: Sissung
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Troutman
authors.forename: Tessa J
authors.initials: TJ
authors.lastname: Campbell
authors.forename: Heather M
authors.initials: HM
authors.lastname: Pressler
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Sung
authors.forename: Susan E
authors.initials: SE
authors.lastname: Bates
authors.forename: William D
authors.initials: WD
authors.lastname: Figg
mesh_terms: D004347:Drug Interactions; D014644:Genetic Variation; D006239:Haplotypes; D006413:Hematopoietic System / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D010597:Pharmacogenetics; D010601:Pharmacology, Clinical; D011110:Polymorphism, Genetic
chemical_list: D026901:Membrane Transport Proteins