title: Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.
abstract: A strategy featuring a multicomponent assembly process followed by an intramolecular azide-alkyne dipolar (Huisgen) cycloaddition was implemented for the facile synthesis of three different 1,2,3-triazolo-1,4-benzodiazepine scaffolds. A diverse library of 170 compounds derived from these scaffolds was then created through N-functionalizations, palladium-catalyzed cross-coupling reactions, and several applications of α-aminonitrile chemistry.
authors.affiliation: Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas, Austin, 78712, United States.
authors.forename: James R
authors.initials: JR
authors.lastname: Donald
authors.forename: Rebekah R
authors.initials: RR
authors.lastname: Wood
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D054852:Small Molecule Libraries; D014230:Triazoles; D001569:Benzodiazepines