title: Eccrine poromatosis associated with polychemotherapy.
abstract: Eccrine poroma frequently occurs as a solitary tumour, and only a few reports have described the occurrence of multiple lesions. Multiple eccrine poromas, or eccrine poromatosis, may occur in patients who have undergone radiotherapy and/or polychemotherapy. We report here four cases of multiple eccrine poromas in patients who were either undergoing, or had undergone, intensive chemotherapy (from 6 months to 16 years prior to onset). Three patients had non-Hodgkin's lymphoma and one had malignant fibrous histiocytosis. The number of lesions varied from 3 to > 20 in each patient, and all the lesions occurred on non-irradiated skin. The histopathological features were consistent with those of eccrine poroma, Pinkus type. In addition to radiation therapy, intensive chemotherapy may play a role in the pathogenesis of multiple eccrine poromas even many years after treatment.
authors.affiliation: Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Fujii
authors.forename: Seiko
authors.initials: S
authors.lastname: Aochi
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Takeshima
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Hamada
authors.forename: Kenji
authors.initials: K
authors.lastname: Asagoe
authors.forename: Yumi
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Shin
authors.initials: S
authors.lastname: Morizane
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwatsuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001706:Biopsy; D046169:Dermoscopy; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000188:drug therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D057091:Poroma / Q000139:chemically induced* / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors