title: Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.
abstract: The immunoproteasome is a specific proteasome isoform induced by interferons. Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress with concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins. Here we discuss how immunoproteasomes protect cells against accumulation of toxic protein-aggregates and how i-proteasomes dysfunction associates with different diseases. We propose that the immunoproteasome has a central function at the interface between the innate and adaptive immune response and that its predominant protective innate function determines its favorable role in the adaptive immune response.
authors.affiliation: Charité - Universitätsmedizin Berlin, Institut für Biochemie CVK, Oudenarder Str. 16, 13347 Berlin, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Krüger
authors.forename: Peter-M
authors.initials: PM
authors.lastname: Kloetzel
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018384:Oxidative Stress; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D046988:Proteasome Endopeptidase Complex