title: Chitosan as a barrier membrane material in periodontal tissue regeneration.
abstract: Periodontal regeneration is defined as regeneration of the tooth-supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.forename: Chang
authors.initials: C
authors.lastname: Lei
authors.forename: Liuyan
authors.initials: L
authors.lastname: Meng
authors.forename: Changning
authors.initials: C
authors.lastname: Wang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Song
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D048271:Chitosan; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D010519:Periodontium; D012038:Regeneration
chemical_list: D008567:Membranes, Artificial; D048271:Chitosan