title: Two novel class I integron arrays containing IMP-18 metallo-β-lactamase gene in Pseudomonas aeruginosa clinical isolates from Puerto Rico.
abstract: During a β-lactam resistance surveillance study, 12 IMP-18-positive Pseudomonas aeruginosa isolates belonging to 9 different pulsed-field gel electrophoresis groups were identified. In nine isolates, a class I integron with a novel gene array was identified that contained bla(IMP-18) and bla(OXA-224), while in two isolates the class I integron contained bla(IMP-18) and bla(OXA-2) but in a new arrangement. Our findings show the dissemination of two novel class I integrons in P. aeruginosa from different regions of Puerto Rico.
authors.affiliation: Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
authors.forename: T
authors.initials: T
authors.lastname: Martínez
authors.forename: G J
authors.initials: GJ
authors.lastname: Vazquez
authors.forename: E E
authors.initials: EE
authors.lastname: Aquino
authors.forename: R V
authors.initials: RV
authors.lastname: Goering
authors.forename: I E
authors.initials: IE
authors.lastname: Robledo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D032023:Integrons / Q000235:genetics*; D008297:Male; D046228:Microarray Analysis; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics*; D011647:Puerto Rico; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C039404:beta-lactamase OXA-2; C428103:beta-lactamase OXA-4; D001618:beta-Lactamases; C527279:beta-lactamase IMP-18, Pseudomonas aeruginosa