title: A randomized prospective trial to assess the impact of transurethral resection in narrow band imaging modality on non-muscle-invasive bladder cancer recurrence.
abstract: BACKGROUND
  Narrow band imaging (NBI) is an optical enhancement technology that filters white light into two bandwidths of illumination centered on 415nm (blue) and 540nm (green). NBI cystoscopy can increase bladder cancer (BCa) visualization and detection at the time of transurethral resection (TUR). NBI may therefore reduce subsequent relapse following TUR.
  
  
  OBJECTIVE
  Assess the impact of NBI modality on 1-yr non-muscle-invasive BCa (NMIBC) recurrence risk.
  
  
  METHODS
  Consecutive patients with overt or suspected BCa were included in a prospective study powered to test a 10% difference in 1-yr recurrence risk in favor of cases submitted to NBI TUR. Excluding patients with muscle-invasive BCa, negative pathologic examination, or without follow-up, the study population was composed of 148 subjects randomized from August 2009 to September 2010 to NBI TUR (76 cases) or white light (WL) TUR (72 cases).
  
  
  METHODS
  TUR was performed in NBI or standard WL modality.
  
  
  METHODS
  The 1-yr recurrence risks in NBI or WL TUR groups were compared using odds ratio (OR) point and interval estimates derived from logistic regression modeling.
  
  
  CONCLUSIONS
  The 1-yr recurrence-risk was 25 of 76 patients (32.9%) in the NBI and 37 of 72 patients (51.4%) in the WL group (OR=0.62; p=0.0141). Simple and multiple logistic regression analyses provided similar OR points and interval estimates.
  
  
  CONCLUSIONS
  TUR performed in the NBI modality reduces the recurrence risk of NMIBC by at least 10% at 1 yr.
authors.affiliation: Department of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. angelo.naselli@libero.it
authors.forename: Angelo
authors.initials: A
authors.lastname: Naselli
authors.forename: Carlo
authors.initials: C
authors.lastname: Introini
authors.forename: Luca
authors.initials: L
authors.lastname: Timossi
authors.forename: Bruno
authors.initials: B
authors.lastname: Spina
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fontana
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pezzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Germinale
authors.forename: Franco
authors.initials: F
authors.lastname: Bertolotto
authors.forename: Paolo
authors.initials: P
authors.lastname: Puppo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*