title: Cytotoxic apigenin derivatives from Chrysopogon aciculatis.
abstract: Four new apigenin derivatives, 7-de-O-methylaciculatin, 8-C-β-D-boivinopyranosylapigenin, aciculatinone, and 4'-O-glucosylaciculatin, along with eight known compounds, apigenin-8-carbaldehyde, kaempferol, tricin, taxifolin, 6,7,4'-trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Jing-Jy
authors.initials: JJ
authors.lastname: Cheng
authors.forename: Horng-Liang
authors.initials: HL
authors.lastname: Lay
authors.forename: Szu-Yuan
authors.initials: SY
authors.lastname: Wu
authors.forename: Ching-Li
authors.initials: CL
authors.lastname: Ni
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Teng
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047310:Apigenin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D019073:HT29 Cells; D006801:Humans; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D006109:Poaceae / Q000737:chemistry*; D013624:Taiwan
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D044949:Kaempferols; C006552:kaempferol; D047310:Apigenin; C017769:tricin