title: Cardiac sarcoidosis: a comprehensive review.
abstract: Sarcoidosis is a multisystem granulomatous disease of unknown etiology characterized by noncaseating granulomas in involved organs. Organs involved with sarcoidosis include lymph nodes, skin, lung, central nervous system, and eye. Only 40-50% of patients with cardiac sarcoidosis diagnosed at autopsy have the diagnosis made during their lifetime. Cardiac sarcoidosis can manifest itself as complete heart block, ventricular arrhythmias, congestive heart failure, pericardial effusion, pulmonary hypertension, and ventricular aneurysms. Diagnostic tests such as the electrocardiogram, two-dimensional echocardiography, cardiac magnetic resonance imaging, positron emission tomography scan, radionuclide scan, and endomyocardial biopsy can be helpful in the early detection of cardiac sarcoidosis. Considering the increased risk of sudden death, cardiac sarcoidosis is an indication for early treatment with corticosteroids or other immunosuppressive agents. Other treatments include placement of a pacemaker or implantable defibrillator to prevent sudden death. In refractory cases, cardiac transplantation should be considered.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, New York Medical College, Valhalla, NY, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sekhri
authors.forename: Shireen
authors.initials: S
authors.lastname: Sanal
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Delorenzo
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: George P
authors.initials: GP
authors.lastname: Maguire