title: Genetics meets environment: evaluating gene-environment interactions in neurologic diseases.
abstract: The vast majority of disease is due to complex relationships between genetic and environmental factors. Single genetic or environmental causes are rare. Unfortunately, this presents major challenges for assessing disease risk in individuals. Further complicating the situation is the fact that there are many ways in which genetic and environmental determinants can combine to cause disease. This review explores the concepts of gene-environment interaction to provide a basic understanding of the principles of interactions and approaches to studying them. Collaborations between genetics and environmental experts will be crucial to understand the complex relationships.
authors.affiliation: Toronto Western Hospital, University of Toronto, Ontario, Canada. cmarras@uhnresearch.ca
authors.forename: Connie
authors.initials: C
authors.lastname: Marras
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Goldman
mesh_terms: D004777:Environment; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000235:genetics; D009422:Nervous System Diseases / Q000209:etiology* / Q000235:genetics*; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics