title: Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy.
abstract: Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.
authors.affiliation: Institut de Recherche Servier, 78290 Croissy/Seine, France. mark.millan@fr.netgrs.com
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Millan
authors.forename: Yves
authors.initials: Y
authors.lastname: Agid
authors.forename: Martin
authors.initials: M
authors.lastname: Brüne
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
authors.forename: Nicola S
authors.initials: NS
authors.lastname: Clayton
authors.forename: Richard
authors.initials: R
authors.lastname: Connor
authors.forename: Sabrina
authors.initials: S
authors.lastname: Davis
authors.forename: Bill
authors.initials: B
authors.lastname: Deakin
authors.forename: Robert J
authors.initials: RJ
authors.lastname: DeRubeis
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
authors.forename: Guy M
authors.initials: GM
authors.lastname: Goodwin
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Thérèse M
authors.initials: TM
authors.lastname: Jay
authors.forename: Marian
authors.initials: M
authors.lastname: Joëls
authors.forename: Isabelle M
authors.initials: IM
authors.lastname: Mansuy
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.forename: Declan
authors.initials: D
authors.lastname: Murphy
authors.forename: Edmund
authors.initials: E
authors.lastname: Rolls
authors.forename: Bernd
authors.initials: B
authors.lastname: Saletu
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.forename: John
authors.initials: J
authors.lastname: Sweeney
authors.forename: Miles
authors.initials: M
authors.lastname: Whittington
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Young
mesh_terms: D001921:Brain / Q000187:drug effects / Q000502:physiology; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D044127:Epigenesis, Genetic / Q000187:drug effects; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy*; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications
chemical_list: D018697:Nootropic Agents