title: SynaptomeDB: an ontology-based knowledgebase for synaptic genes.
abstract: BACKGROUND
  The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.
  
  
  RESULTS
  We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA. mpirooz1@jhmi.edu
authors.forename: Mehdi
authors.initials: M
authors.lastname: Pirooznia
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: David
authors.initials: D
authors.lastname: Valle
authors.forename: Gareth
authors.initials: G
authors.lastname: Thomas
authors.forename: Richard L
authors.initials: RL
authors.lastname: Huganir
authors.forename: Fernando S
authors.initials: FS
authors.lastname: Goes
authors.forename: James B
authors.initials: JB
authors.lastname: Potash
authors.forename: Peter P
authors.initials: PP
authors.lastname: Zandi
mesh_terms: D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D011506:Proteins / Q000235:genetics; D013569:Synapses / Q000235:genetics* / Q000378:metabolism*
chemical_list: D011506:Proteins