title: Predictive index for the onset of medication overuse headache in migraine patients.
abstract: Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as significant factors that contribute independently to the development from migraine to MOH (P < 0.05). The regression coefficients (β) of these four selected factors were approximated and scored. The PI score in MOH patients (7.32 ± 1.60) was significantly higher than that in migraine patients (4.62 ± 1.83, P < 0.001). The proposed scoring system should in the future be the object of larger studies to confirm its validity.
authors.affiliation: Department of Pathophysiology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Onaya
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Kasai
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Kiuchi
mesh_terms: D000328:Adult; D017668:Age of Onset; D017931:DNA Primers; D005260:Female; D005838:Genotype; D051271:Headache Disorders, Secondary / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D020325:Migraine with Aura / Q000150:complications / Q000188:drug therapy; D020326:Migraine without Aura / Q000150:complications / Q000188:drug therapy; D010551:Personality; D010556:Personality Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D011237:Predictive Value of Tests; D060888:Real-Time Polymerase Chain Reaction; D017448:Receptors, Dopamine D2 / Q000235:genetics; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D017931:DNA Primers; D017448:Receptors, Dopamine D2; D042965:Methylenetetrahydrofolate Reductase (NADPH2)