title: Understanding the physiological roles of the neuronal calcium sensor proteins.
abstract: Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca2+ concentration are detected by Ca2+-binding proteins that can interact with and regulate target proteins to modify their function. Members of the neuronal calcium sensor (NCS) protein family have multiple non-redundant roles in the nervous system. Here we review recent advances in the understanding of the physiological roles of the NCS proteins and the molecular basis for their specificity.
authors.affiliation: Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. burgoyne@liv.ac.uk
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burgoyne
authors.forename: Lee P
authors.initials: LP
authors.lastname: Haynes
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D051580:Neuronal Calcium-Sensor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D025941:Protein Interaction Mapping
chemical_list: D051580:Neuronal Calcium-Sensor Proteins; D002118:Calcium