title: Cyclopropane- and spirolimonoids and related compounds from Hortia oreadica.
abstract: The dichloromethane extract from taproots of Hortia oreadica afforded six limonoids, these are 9,11-dehydro-12α-acetoxyhortiolide A, hortiolide C, 11α-acetoxy-15-deoxy-6-hydroxyhortiolide C, hortiolide D, hortiolide E, 12β-hydroxyhortiolide E, in addition to the known limonoid, guyanin. The dichloromethane extract from stems of H. oreadica also afforded two limonoids 9,11-dehydro-12α-hydroxyhortiolide A and 6-hydroxyhortiolide C. As a result of this study and literature data, Hortia has been shown to produce highly specialized limonoids that are similar to those from the Flindersia (Flindersioideae). The taxonomy of Hortia has been debatable, with most authors placing it in the Toddalioideae. Considering the complexity of the isolated limonoids, Hortia does not show any close affinity to the genera of Toddalioideae. That is, the limonoids appear to be of little value in resolving the taxonomic situation of Hortia.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
authors.forename: Vanessa G P
authors.initials: VG
authors.lastname: Severino
authors.forename: Patrícia A C
authors.initials: PA
authors.lastname: Braga
authors.forename: Maria Fátima das G F
authors.initials: MF
authors.lastname: da Silva
authors.forename: João B
authors.initials: JB
authors.lastname: Fernandes
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Vieira
authors.forename: Jahyr E
authors.initials: JE
authors.lastname: Theodoro
authors.forename: Javier A
authors.initials: JA
authors.lastname: Ellena
mesh_terms: D005591:Chemical Fractionation / Q000379:methods; D003521:Cyclopropanes / Q000737:chemistry* / Q000302:isolation & purification; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008752:Methylene Chloride / Q000737:chemistry; D015394:Molecular Structure; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry* / Q000145:classification; D014961:X-Ray Diffraction
chemical_list: D003521:Cyclopropanes; D036701:Limonins; D010936:Plant Extracts; C572810:hortiolide; D008752:Methylene Chloride