title: Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging.
abstract: The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in mammalian lifespan regulation and age-related diseases such as type II diabetes mellitus and cancer. The role of mTORC1-S6K1 in age-related cardiovascular diseases is, however, largely unknown and the available experimental results are controversial. This review article primarily summarizes the most recent advances toward understanding the role of mTORC1-S6K1 in cardiovascular aging and discusses the future perspectives of targeting mTORC1-S6K1 signaling as a healthy lifespan extension modality in anti-aging and anti-cardiovascular aging.
authors.affiliation: Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg Fribourg, Switzerland.
authors.forename: Xiu-Fen
authors.initials: XF
authors.lastname: Ming
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Montani
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Yang