title: Analysis of progression of reticular pseudodrusen by spectral domain-optical coherence tomography.
abstract: OBJECTIVE
  To analyze reticular pseudodrusen progression using spectral domain-optical coherence tomography (SD-OCT).
  
  
  METHODS
  Thirty-three consecutive patients (48 eyes) underwent SD-OCT using the eye-tracked follow-up protocol 24 ± 2 months after baseline examination. Each pair of B-scans (only one per eye was evaluated among those showing pseudodrusen progression) was compared with respect to pseudodrusen appearance and retinal layer structure. Stage 1 pseudodrusen was defined as granular material between the RPE and the inner segment/outer segment (IS/OS), stage 2 as mounds of material sufficient to alter the contour of the IS/OS, stage 3 as thicker material adopting a conical appearance and breaking through the IS/OS, and stage 4 as fading of the material because of reabsorption and migration within the inner retinal layers.
  
  
  RESULTS
  A total of 78 pseudodrusen (detected on the 48 analyzed B-scans, and counting for a mean of 2.3 pseudodrusen per scan) showed progression over a mean of 23.9 ± 1.2 months. All 58 pseudodrusen (100%) graded as stage 1 at baseline examination progressed to stage 2. Thirteen of 16 pseudodrusen (81.3%) graded as stage 2 at baseline examination progressed to stage 3, and three (18.7%) progressed to stage 4. All four pseudodrusen (100%) graded as stage 3 at baseline examination progressed to stage 4. Among pseudodrusen that were stage 3 or 4 at follow-up (n = 20), 100% had IS/OS disruption whereas 12.1% (n = 7) had IS/OS disruption at stage 1 or 2 (n = 58) (OR, 1.736; 95% CI, 1.02-2.43).
  
  
  CONCLUSIONS
  The frequency of stage changes over time suggest that reticular pseudodrusen are dynamic pathologic structures.
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France. giuseppe.querques@hotmail.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Florence
authors.initials: F
authors.lastname: Canouï-Poitrine
authors.forename: Florence
authors.initials: F
authors.lastname: Coscas
authors.forename: Nathalie
authors.initials: N
authors.lastname: Massamba
authors.forename: Lea
authors.initials: L
authors.lastname: Querques
authors.forename: Gerard
authors.initials: G
authors.lastname: Mimoun
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D011379:Prognosis; D015593:Retinal Drusen / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D041623:Tomography, Optical Coherence / Q000379:methods*