title: Electrocardiographic toxicity in the guinea pig.
abstract: Abnormalities of cardiac rhythm are one of the most common clinical problems in cardiology and arise as the result of either disorders of cardiac impulse formation or conduction, or a combination of both. It has been established that some classes of drugs, such as tricyclic antidepressants (e.g., imipramine), cardiac glycosides (e.g., digoxin), and Class I or Class III antiarrhythmic drugs (e.g., quinidine or amiodarone) can produce electrocardiographic toxicity in humans. It is therefore highly advisable to assess the effect of any new compound in this respect, during the early phases of drug development. This unit presents a protocol to detect the electrocardiographic toxicity of compounds in the anesthetized guinea pig.
authors.affiliation: Porsolt and Partners Pharmacology, Boulogne Billancourt, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lacroix
mesh_terms: D000639:Amitriptyline / Q000633:toxicity; D000758:Anesthesia / Q000379:methods; D000818:Animals; D004195:Disease Models, Animal; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis*; D004562:Electrocardiography / Q000187:drug effects*; D006168:Guinea Pigs; D006323:Heart Arrest / Q000139:chemically induced*; D008297:Male; D010208:Papaverine / Q000633:toxicity; D011802:Quinidine / Q000633:toxicity; D013048:Specimen Handling / Q000379:methods
chemical_list: D000639:Amitriptyline; D010208:Papaverine; D011802:Quinidine