title: Focal nodular hyperplasia in the livers of cynomolgus macaques (macaca fascicularis).
abstract: Two cases of spontaneous focal hepatic hyperplasia were observed in young female cynomolgus macaques (Macaca fascicularis). Grossly, a single raised nodule was observed in the left hepatic lobe. Histopathologically, the nodule compressed surrounding normal tissue; however, the hepatic cords within the nodule continued to those in the nor mal area except in part. Extensive fibrosis and absence of a normal hepatic triad were observed in the nodule. Thin fibrous septa radiating from the dense central stellate scarring and distended vessels were apparent in one animal. Hepatocytes in the nodule lacked cellular atypia, showed frequent PAS-positive eosinophilic inclusions in the cytoplasm and showed higher positive ratios for PCNA. The present cases resembled focal nodular hyperplasia reported in humans and a chimpanzee.
authors.affiliation: Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Fujishima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Satake
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Furukawa
authors.forename: Chika
authors.initials: C
authors.lastname: Kurokawa
authors.forename: Rinya
authors.initials: R
authors.lastname: Kodama
authors.forename: Akiko
authors.initials: A
authors.lastname: Moriyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kamimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeda