title: HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cells.
abstract: To better understand the qualitative features of effective human immunodeficiency virus (HIV)-specific immunity, we examined the TCR clonal composition of CD8(+) T cells recognizing conserved HIV p24-derived epitopes in HLA-B*5701-positive long-term nonprogressors/elite controllers (LTNP/EC) and HLA-matched progressors. Both groups displayed oligoclonal HLA-B5701-restricted p24-specific CD8(+) T-cell responses with similar levels of diversity and few public clonotypes. Thus, HIV-specific CD8(+) T-cell responses in LTNP/EC are not differentiated from those of progressors on the basis of clonal diversity or TCR sharing.
authors.affiliation: HIV-Specific Immunity Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland,USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Mendoza
authors.forename: Cassandra
authors.initials: C
authors.lastname: Royce
authors.forename: Laura E
authors.initials: LE
authors.lastname: Ruff
authors.forename: David R
authors.initials: DR
authors.lastname: Ambrozak
authors.forename: Máire F
authors.initials: MF
authors.lastname: Quigley
authors.forename: Thurston
authors.initials: T
authors.lastname: Dang
authors.forename: Vanessa
authors.initials: V
authors.lastname: Venturi
authors.forename: David A
authors.initials: DA
authors.lastname: Price
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Douek
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Migueles
authors.forename: Mark
authors.initials: M
authors.lastname: Connors
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D060966:Clonal Selection, Antigen-Mediated; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D020276:HIV Long-Term Survivors / Q000706:statistics & numerical data; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D013045:Species Specificity
chemical_list: D015235:HLA-B Antigens