title: No association between the CYP1B1 C4326G polymorphism and endometrial cancer risk: a meta-analysis.
abstract: OBJECTIVE
  Any association between the CYP1B1 C4326G polymorphism and endometrial cancer risk remains inconclusive. In order to provide a more precise estimate, we performed the present meta-analysis.
  
  
  METHODS
  We used fixed effect or random effect models to estimate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for endometrial cancer risk, with the Chi-square-based Q-test used to test for heterogeneity. Begg's and Egger's tests were adopted to check publication bias.
  
  
  RESULTS
  Six published case-control studies of association between the CYP1B1 C4326G polymorphism and endometrial cancer risk covering 6,577 subjects were included in the meta-analysis, but the results indicated no significant correlation with allele contrast and genotype comparisons (G vs C: OR 1.01, 95% CI 0.93-1.09; GG vs CC: OR 1.04, 95% CI 0.88-1.23; CG + GG vs CC: OR 1.08, 95% CI 0.97-1.21; GG vs CC + CG: OR 1.01, 95% CI 0.87-1.17). Heterogeneity hypothesis test did not reveal any heterogeneity and Begg's and Egger's tests did not detect obvious publication bias.
  
  
  CONCLUSIONS
  There is no association between the CYP1B1 C4326G polymorphism and endometrial cancer risk.
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, China.
authors.forename: Xi-wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Yu-li
authors.initials: YL
authors.lastname: Chen
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Luo
authors.forename: Qing-yi
authors.initials: QY
authors.lastname: Liu
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D065633:Cytochrome P-450 CYP1B1; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1