title: [Effects of Tongxinluo on neuron ultrastructure and endothelial cell self-repairing ability in hypoxia preconditioning mice].
abstract: OBJECTIVE
  To observe the ultrastructure changes of cerebral cortex neuron and endothelial cell in hypoxia preconditioning mice and the effects of Tongxinluo (TXL, Chinese traditional medilihe) on them.
  
  
  METHODS
  Mice were randomly divided into 4 groups: control group, hypoxia group, hypoxia preconditioning (HP) group and Tongxinluo (TXL) group. The hypoxia preconditioning mice were exposed by repetitive hypoxia for 5 runs. The animal's tolerance time of each hypoxia run was recorded. The ultrastructure change of cerebral neuron and endothelial cell were studied by electron microscope.
  
  
  RESULTS
  The hypoxic tolerance time in HP and TXL groups were significantly increased run by run. Compared with HP group, the tolerance time of TXL group were increased in every run. The ultrastructure of cerebral neuron and endothelial cell in hypoxia group changed obviously, mitochondrion and endoplasmic reticulum destroyed. However they were slighter in HP group than those in hypoxia group. The change in TXL group had no obvious differentce with control group and were slighter than those in HP group.
  
  
  CONCLUSIONS
  Hypoxia preconditioning shows that organism has a strong self-repairing ability. Tongxinluo self-repairing; could increase self-repairing ability and adaptive ability of mice to hypoxia obviously.
authors.affiliation: Hebei Yiling Pharmaceutical Research Institute, Shijiazhuang 050035, China. wxc2222@163.com
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Lai
authors.forename: Xiang-Feng
authors.initials: XF
authors.lastname: Wu
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Jia
authors.forename: Cong
authors.initials: C
authors.lastname: Wei
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Wang
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D042783:Endothelial Cells / Q000648:ultrastructure*; D000860:Hypoxia / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology*; D019194:Ischemic Preconditioning / Q000379:methods; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D004365:Drugs, Chinese Herbal; C513941:tongxinluo