title: Solanezumab for the treatment of mild-to-moderate Alzheimer's disease.
abstract: Solanezumab (LY2062430) is a humanized monoclonal antibody that binds to the central region of β-amyloid, a peptide believed to play a key role in the pathogenesis of Alzheimer's disease (AD). Eli Lilly & Co is developing an intravenous formulation of solanezumab for the treatment of mild-to-moderate AD. Acute and subchronic treatment with solanezumab of transgenic mice attenuated or reversed memory deficits with no effects on incidence or severity of cerebral amyloid angiopathy-associated microhemorrhages, a severe side effect associated with bapineuzumab, another monoclonal antibody. Phase II studies in AD patients have shown a good safety profile with encouraging indications on cerebrospinal and plasma biomarkers. The drug is currently being investigated in Phase III trials. While there is a strong hope that solanezumab may represent the first effective passive vaccine for AD treatment, skepticism still exists on the ability of the drug to slow the rate of deterioration in patients with fully established disease.
authors.affiliation: Research and Development Department, Chiesi Farmaceutici, Parma, Italy. b.imbimbo@chiesigroup.com
authors.forename: Bruno P
authors.initials: BP
authors.lastname: Imbimbo
authors.forename: Simone
authors.initials: S
authors.lastname: Ottonello
authors.forename: Vincenza
authors.initials: V
authors.lastname: Frisardi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Greco
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000276:immunology; D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000276:immunology / Q000627:therapeutic use*; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D016229:Amyloid beta-Peptides; D061067:Antibodies, Monoclonal, Humanized; C550616:solanezumab