title: Role of PD-L1/PD-1 in the immune response to respiratory viral infections.
abstract: Airway epithelial cells are the main cells infected by respiratory viruses including rhinoviruses and respiratory syncytial virus. Virus modulation of inhibitory molecule PD-L1 on epithelial cells may be important in limiting anti-viral effector CD8(+) T cell responses and, consequently, worsening acute virus-induced lung tissue damage.
authors.affiliation: Oncology Institute Prof. Dr. Ion Chiricuta, Department of Hematology, and University of Medicine and Pharmacy, Cluj-Napoca, Romania. mzdrenghea@umfcluj.ro
authors.forename: Mihnea Tudor
authors.initials: MT
authors.lastname: Zdrenghea
authors.forename: Sebastian Lennox
authors.initials: SL
authors.lastname: Johnston
mesh_terms: D000818:Animals; D060890:B7-H1 Antigen / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004847:Epithelial Cells / Q000276:immunology / Q000821:virology; D006801:Humans; D007223:Infant; D008168:Lung / Q000166:cytology / Q000276:immunology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology* / Q000472:pathogenicity; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000821:virology; D012229:Rhinovirus / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor