title: Influence of the in situ component in 389 infiltrating ductal breast carcinomas.
abstract: BACKGROUND
  Our aim was to evaluate and compare lymph node involvement, as well as disease-free survival (DFS) and overall survival (OS), between infiltrating ductal carcinoma with (group 1) and without (group 2) intraductal carcinoma component in order to determine the prognostic value of the intraductal component.
  
  
  METHODS
  Data from 389 cases of infiltrating ductal carcinoma of the breast were included in the study by means of reviewing medical charts and pathology slides.
  
  
  RESULTS
  There was no statistically significant difference between both groups regarding node status. The 5-year DFS rate was 90.7% in group 1 and 81.8% in group 2 (p = 0.014), with a median follow-up of 73.2 months (95% CI 68.3-77.4). There was no statistically significant difference in 5-year OS between groups (98% group 1 vs. 93% group 2) with a median global survival of 134 months (95% CI 131-137).
  
  
  CONCLUSIONS
  The presence of intraductal component in the infiltrating carcinoma seems to increase DFS and may be an independent and favorable prognostic factor for breast cancer.
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Dexeus University Institute, Barcelona, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Carabias-Meseguer
authors.forename: Ignacio
authors.initials: I
authors.lastname: Zapardiel
authors.forename: Maite
authors.initials: M
authors.lastname: Cusidó-Gimferrer
authors.forename: Sonia
authors.initials: S
authors.lastname: Godoy-Tundidor
authors.forename: Francesc
authors.initials: F
authors.lastname: Tresserra-Casas
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez-García
authors.forename: Rafael
authors.initials: R
authors.lastname: Fábregas-Xauradó
authors.forename: Jordi
authors.initials: J
authors.lastname: Xercavins-Montosa
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000401:mortality* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D015996:Survival Rate