title: Epstein-Barr virus neutralizing antibody levels and risk of multiple sclerosis.
abstract: Previous infection with Epstein-Barr virus (EBV) and infectious mononucleosis are established multiple sclerosis (MS) risk factors, and elevated serum titers of anti-EBV nuclear antigen (anti-EBNA) antibodies in healthy adults are strongly correlated with future MS risk. In this prospective study, we investigated the association between EBV neutralizing antibodies and MS risk. MS risk tended to be higher in individuals with high titers of neutralizing antibodies compared to those with low titers (relative risk [RR] = 2.2, 95% confidence interval [CI] 0.97-5.1). This association was attenuated after adjustment for anti-EBNA1 IgG Ab titers (RR = 1.4, 95% CI 0.5-3.5). This preliminary finding warrants further study in a larger population.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. ksimon@hsph.harvard.edu
authors.forename: Kelly Claire
authors.initials: KC
authors.lastname: Simon
authors.forename: Eilis J
authors.initials: EJ
authors.lastname: O'Reilly
authors.forename: Kassandra L
authors.initials: KL
authors.lastname: Munger
authors.forename: Susan
authors.initials: S
authors.lastname: Finerty
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Morgan
authors.forename: Alberto
authors.initials: A
authors.lastname: Ascherio
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000276:immunology*; D016017:Odds Ratio; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015854:Up-Regulation; D014763:Viral Matrix Proteins / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D014763:Viral Matrix Proteins