title: The SAMP8 mouse: a model to develop therapeutic interventions for Alzheimer's disease.
abstract: The senescence accelerate mouse P8 (SAMP8) is an excellent model of early learning and memory problems. A number of studies have shown that it has cholinergic deficits, oxidative damage, alterations in membrane lipids and circadian rhythm disturbances. The brains of the SAMP8 overproduce amyloid precursor protein (APP), amyloid-beta protein and have an increased physphorylation of tau. An antisense to APP has been developed that reverses the cognitive deficits and oxidative damage. This antisense represents a potential treatment for Alzheimer's disease.
authors.affiliation: Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. morley@slu.edu
authors.forename: John E
authors.initials: JE
authors.lastname: Morley
authors.forename: Susan A
authors.initials: SA
authors.lastname: Farr
authors.forename: Vijaya B
authors.initials: VB
authors.lastname: Kumar
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Armbrecht
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002940:Circadian Rhythm; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D008563:Membrane Lipids; D016376:Oligonucleotides, Antisense