title: Photodynamic effect in near-IR light by a photocytotoxic iron(III) cellular imaging agent.
abstract: A red light for cancer cells: an iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.
authors.affiliation: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka, India.
authors.forename: Uttara
authors.initials: U
authors.lastname: Basu
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.forename: Akhtar
authors.initials: A
authors.lastname: Hussain
authors.forename: Paturu
authors.initials: P
authors.lastname: Kondaiah
authors.forename: Akhil R
authors.initials: AR
authors.lastname: Chakravarty
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D053837:DNA Cleavage; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D018613:Microscopy, Confocal; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D005290:Ferric Compounds; D017319:Photosensitizing Agents; D004247:DNA