title: Morphological and biochemical investigation into the possible neuroprotective effects of kolaviron (Garcinia kola bioflavonoid) on the brains of rats exposed to vanadium.
abstract: In this study, the morphological and biochemical susceptibility of the rat brain to vanadium, in the form of sodium metavanadate, and the comparative ameliorative effect of Garcinia kola and kolaviron (G. kola extract), was examined. Brain regions examined were the cerebrum, cerebellum, hippocampus and the olfactory bulb. We showed that vanadium administration caused cellular vacuolation, congestion, and Purkinje cell degeneration and a marked reduction in myelin tracts. Biochemical tests revealed increased lipid peroxidation induced by vanadium, which was ameliorated with the administration of G. kola and kolaviron. Vanadium administration caused an increase in thiobarbituric acid-reactive substances (TBARS) in the cerebrum and hippocampus, whereas the administration of kolaviron resulted in a reduction of the TBARS level by 65.7 and 80%, respectively, in the regions aforementioned. Also, the administration of kolaviron resulted in an increased activity of superoxide dismutase (61.24%) in all brain regions assessed, when compared with the group administered vanadium alone. Results obtained from this study led to the conclusion that kolaviron reduces vanadium-induced oxidative stress in the brain.
authors.affiliation: Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
authors.forename: Olumayowa O
authors.initials: OO
authors.lastname: Igado
authors.forename: James O
authors.initials: JO
authors.lastname: Olopade
authors.forename: Adebukola
authors.initials: A
authors.lastname: Adesida
authors.forename: Oluwasanmi O
authors.initials: OO
authors.lastname: Aina
authors.forename: Ebenezer O
authors.initials: EO
authors.lastname: Farombi
mesh_terms: D000818:Animals; D000931:Antidotes / Q000302:isolation & purification / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000473:pathology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D029763:Garcinia kola / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000209:etiology; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014638:Vanadates / Q000008:administration & dosage / Q000633:toxicity; D014639:Vanadium / Q000633:toxicity*
chemical_list: D000931:Antidotes; D005419:Flavonoids; D018696:Neuroprotective Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014639:Vanadium; D014638:Vanadates; D013482:Superoxide Dismutase; C045492:kolaviron