title: Clinical outcome of patients treated with an early invasive strategy after out-of-hospital cardiac arrest.
abstract: Little is known about the impact of early invasive treatment in patients following out-of-hospital cardiac arrest (OHCA). The present study investigated the clinical characteristics and long-term prognosis of 1254 patients with suspected acute coronary syndrome, including 65 with OHCA  who underwent successful cardiopulmonary resuscitation (CPR) and 1189 patients who did not require CRP. All patients underwent immediate coronary angiography even if clear signs of myocardial infarction (MI) were absent. The incidence of ST-elevation and non-ST-elevation MI did not differ  between the two groups. Cardiac biomarkers were significantly higher in CPR patients despite a shorter period from symptom onset to admission. The 6-month mortality rate was 29% in the CPR group and 4% in the non-CPR group, with > 90% of fatalities occurring ≤ 3 weeks after admission.  In summary, early invasive treatment leads to a considerably reduced mortality and improved prognosis in patients after OHCA.
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Centre, Bad Nauheim, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Möllmann
authors.forename: S
authors.initials: S
authors.lastname: Szardien
authors.forename: C
authors.initials: C
authors.lastname: Liebetrau
authors.forename: A
authors.initials: A
authors.lastname: Elsässer
authors.forename: J
authors.initials: J
authors.lastname: Rixe
authors.forename: A
authors.initials: A
authors.lastname: Rolf
authors.forename: H
authors.initials: H
authors.lastname: Nef
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: C
authors.initials: C
authors.lastname: Hamm
mesh_terms: D054058:Acute Coronary Syndrome / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D016887:Cardiopulmonary Resuscitation; D005260:Female; D005858:Germany / Q000453:epidemiology; D006339:Heart Rate / Q000502:physiology; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D018570:Risk Assessment; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers