title: Synthesis, spectral characterization and in vitro antimicrobial activity of some new azopyridine derivatives.
abstract: A series of arylpicolino and/or isonicotinohydrazonyl cyanide 2a-d and 4a-f were prepared by coupling the approprite aryl diazonium salt with 2-cyanomethyl and/or 4-cyanomethyl-pyridine, respectively. These compounds were characterized by analytical and spectral analyses and screened for their antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and antifungal activity. Among the synthesized compounds, N'-(4-phenyldiazenyl)phenylisonicotinohydrazonyl cyanide 4f showed a significant activity toward both Gram-positive, Gram-negative bacteria and exhibit the most potent in vitro antifungal with MIC's (625 μg/mL) against Aspergillus nieger.
authors.affiliation: Faculty of Education of Girls, King Khaled University, Abha, Saudi Arabia.
authors.forename: Hanaa
authors.initials: H
authors.lastname: Abuo-Melha
authors.forename: A A
authors.initials: AA
authors.lastname: Fadda
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D001391:Azo Compounds; D011725:Pyridines; C023666:pyridine