title: Elaboration of chitosan-coated nanoparticles loaded with curcumin for mucoadhesive applications.
abstract: Polycaprolactone (PCL) nanoparticles decorated with a mucoadhesive polysaccharide chitosan (CS) containing curcumin were developed aiming the buccal delivery of this drug. These nanoparticles were prepared by the nanoprecipitation method using different molar masses and concentrations of chitosan and concentrations of triblock surfactant poloxamer (PEO-PPO-PEO), in order to optimize the preparation conditions. Chitosan-coated nanoparticles showed positive surface charge and a mean particle radius ranging between 114 and 125 nm, confirming the decoration of the nanoparticles with the mucoadhesive polymer, through hydrogen bonds between ether and amino groups from PEO and CS, respectively. Dynamic Light Scattering (DLS) studies at different scattering angles and concentrations have shown that the nanoparticles are monodisperse (polydispersity indices were lower than 0.3). The nanoparticle systems were also examined with Nanoparticle Tracking Analysis (NTA), and the results were in good agreement with those obtained by DLS. Colloidal systems showed mean drug content about 460 μg/mL and encapsulation efficiency higher than 99%. Finally, when coated with chitosan, these nanoparticles show a great ability to interact with mucin indicating also their suitability for mucoadhesive applications.
authors.affiliation: Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier and member of the Institut de Chimie Moléculaire de Grenoble, BP 53, F-38041 Grenoble Cedex 9, France. leticia.mazzarino@cermav.cnrs.fr
authors.forename: Letícia
authors.initials: L
authors.lastname: Mazzarino
authors.forename: Christophe
authors.initials: C
authors.lastname: Travelet
authors.forename: Sonia
authors.initials: S
authors.lastname: Ortega-Murillo
authors.forename: Issei
authors.initials: I
authors.lastname: Otsuka
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pignot-Paintrand
authors.forename: Elenara
authors.initials: E
authors.lastname: Lemos-Senna
authors.forename: Redouane
authors.initials: R
authors.lastname: Borsali
mesh_terms: D000278:Administration, Buccal; D048271:Chitosan / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008027:Light; D009077:Mucins / Q000737:chemistry; D009088:Mucoproteins / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D012542:Scattering, Radiation; D013499:Surface Properties
chemical_list: C115439:BSM1 protein, Bos taurus; D004337:Drug Carriers; D009077:Mucins; D009088:Mucoproteins; C116176:PEO-PPO-PEO; D011409:Propylene Glycols; D011092:Polyethylene Glycols; D048271:Chitosan; D003474:Curcumin