title: In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization.
abstract: Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA. mdmansouri@aol.com
authors.forename: Mohammad D
authors.initials: MD
authors.lastname: Mansouri
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Opperman
authors.forename: John D
authors.initials: JD
authors.lastname: Williams
authors.forename: Charles
authors.initials: C
authors.lastname: Stager
authors.forename: Rabih O
authors.initials: RO
authors.lastname: Darouiche
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D055499:Catheter-Related Infections / Q000382:microbiology* / Q000517:prevention & control*; D057785:Catheters / Q000382:microbiology*; D015169:Colony Count, Microbial; D003470:Culture Media; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D007211:Indoles; C573061:MBX1631