title: Cancer survivors in the United States: a review of the literature and a call to action.
abstract: BACKGROUND
  The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds alive at five years. The most common cancer diagnoses among survivors include breast, prostate and colorectal cancers. This review was conducted to better appreciate the challenges associated with cancer survivors and the opportunities healthcare providers have in making a difference for these patients.
  
  
  METHODS
  Comprehensive review of literature based on PubMed searches on topics related to cancer survivorship, and associated physical, cognitive, socio-economic, sexual/behavioral and legal issues.
  
  
  RESULTS
  At least 50% of cancer survivors suffer from late treatment-related side effects, often including physical, psychosocial, cognitive and sexual abnormalities, as well as concerns regarding recurrence and/or the development of new malignancies. Many are chronic in nature and some are severe and even life-threatening. Survivors also face issues involving lack of appropriate health maintenance counseling, increased unemployment rate and workplace discrimination.
  
  
  CONCLUSIONS
  Advances in the diagnosis and treatment of cancer will lead to more survivors and better quality of life. However, tools to recognize potentially serious long-lasting side effects of cancer therapy earlier in order to treat and/or prevent them must be developed. It is incumbent upon our health care delivery systems to make meeting these patients' needs a priority.
authors.affiliation: Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA. manuelva@med.umich.edu
authors.forename: Manuel
authors.initials: M
authors.lastname: Valdivieso
authors.forename: Ann M
authors.initials: AM
authors.lastname: Kujawa
authors.forename: Tisha
authors.initials: T
authors.lastname: Jones
authors.forename: Laurence H
authors.initials: LH
authors.lastname: Baker
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D003376:Counseling; D015438:Health Behavior; D006321:Heart / Q000187:drug effects; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000401:mortality*; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D011788:Quality of Life; D017741:Survivors; D014481:United States
chemical_list: D000970:Antineoplastic Agents