title: Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.
abstract: The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
authors.affiliation: McGill Centre for the Study of Host Resistance, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Cobat
authors.forename: Luis F
authors.initials: LF
authors.lastname: Barrera
authors.forename: Hanna
authors.initials: H
authors.lastname: Henao
authors.forename: Patricia
authors.initials: P
authors.lastname: Arbeláez
authors.forename: Laurent
authors.initials: L
authors.lastname: Abel
authors.forename: Luis F
authors.initials: LF
authors.lastname: García
authors.forename: Erwin
authors.initials: E
authors.lastname: Schurr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alcaïs
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D005191:Family Characteristics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014374:Tuberculin Test / Q000379:methods*; D055815:Young Adult