title: Photocaged DNA provides new levels of transcription control.
abstract: Spot lit: photocaged nucleic acids have been used to regulate gene expression through the action of light. Whereas most methods target mRNAs, DNA decoys have recently been used to target DNA transcription by targeting specific DNA-transcription-factor interactions. This has allowed researchers to "turn-off" transcription through the action of light on caged nucleic acids for the first time.
authors.affiliation: Department of Chemistry and Biochemistry, University of Delaware, Brown Laboratories, USA.
authors.forename: Luke M
authors.initials: LM
authors.lastname: Ceo
authors.forename: John T
authors.initials: JT
authors.lastname: Koh
mesh_terms: D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D008027:Light; D055668:Photochemical Processes; D010957:Plasmids / Q000235:genetics / Q000528:radiation effects; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D004247:DNA