title: The role of post-transplantation cyclosporine treatment in the course of cystic fibrosis pulmonary disease: a case report.
abstract: We describe the case of a 44-year-old female cystic fibrosis (CF) patient (R334W/852del22) who presented symptoms of prolonged acute respiratory infections and recurrent episodes of pneumonia. Computed tomography (CT) scan images of the chest showed that the patient presented airway and parenchymal changes throughout both lungs. She also had decreased lung function performances. In March 2004, she underwent live-related donor renal transplant and started an immunosuppressive therapy with cyclosporine. CT scan images taken respectively 2 and 6 years after transplantation documented a progressive significant size reduction of structural lung damages in both lungs and clinical signs and symptoms of improvements.
authors.affiliation: Department of Biomedicine of the Developing Age, Apulian Referral Center for Cystic Fibrosis, Pediatric Unit "B. Trambusti", University of Bari, Bari, Italy. nucciatesse@googlemail.com
authors.forename: Riccardina
authors.initials: R
authors.lastname: Tesse
authors.forename: Antonio
authors.initials: A
authors.lastname: Manca
authors.forename: Maria Raffaella
authors.initials: MR
authors.lastname: Abrusci
authors.forename: Silvia
authors.initials: S
authors.lastname: Pinto
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Leonetti
authors.forename: Silvia
authors.initials: S
authors.lastname: De Robertis
authors.forename: Luciano
authors.initials: L
authors.lastname: Cavallo
authors.forename: Francesco
authors.initials: F
authors.lastname: De Robertis
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage*; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation; D008168:Lung / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine