title: An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy.
abstract: We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.
authors.affiliation: Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Park
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.forename: Nam Muk
authors.initials: NM
authors.lastname: Oh
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000586:Amination; D001692:Biological Transport; D004024:Dicyclohexylcarbodiimide / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000378:metabolism; D013388:Succinimides / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D011355:Prodrugs; D013388:Succinimides; D011092:Polyethylene Glycols; D004024:Dicyclohexylcarbodiimide