title: Oral tolerance induction for human food allergy.
abstract: Food allergies are classified as IgE-mediated and non-IgE mediated type. The number of successful reports of immunotherapy, namely tolerance induction for food allergy (TIFA) are increasing, bringing hope for meaningful positive and radical treatment of food allergy. Therapeutic characteristics of the clinical course in TIFA for NFA are different from TIFA for IFA. Cytokines including IL-10, TGF-β and IFN-γ and regulatory cells such as Treg and Breg, are involved in immune tolerance. IFN-γ has been used for tolerance induction of food allergy as an immunomodulatory biologics. A definitive distinction between IgE-mediated and non-IgE-mediated food allergies is absolutely essential for diagnostic and therapeutic purposes. Original SOTI using IFN-γ is more effective then conventional SOTI without IFN-γ. Especially, IFN-γ is absolutely necessary for the tolerance induction of NFA. This review highlights and updates the advances in the conceptual immunological background and the clinical characteristics of oral tolerance induction for food allergy.
authors.affiliation: Subdivision of Allergy and Clinical Immunology, Department of Paediatrics, Chungnam National University Hospital, Jung-gu, Daejeon, Republic of Korea. admyth@naver.com
authors.forename: Geunwoong
authors.initials: G
authors.lastname: Noh
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology; D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000276:immunology; D003888:Desensitization, Immunologic; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000276:immunology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000485:Allergens; D016207:Cytokines; D007073:Immunoglobulin E