title: A rat brain MRI template with digital stereotaxic atlas of fine anatomical delineations in paxinos space and its automated application in voxel-wise analysis.
abstract: This study constructs a rat brain T2 -weighted magnetic resonance imaging template including olfactory bulb and a compatible digital atlas. The atlas contains 624 carefully delineated brain structures based on the newest (2005) edition of rat brain atlas by Paxinos and Watson. An automated procedure, as an SPM toolbox, was introduced for spatially normalizing individual rat brains, conducting statistical analysis and visually localizing the results in the Atlas coordinate space. The brain template/atlas and the procedure were evaluated using functional images between rats with the right side middle cerebral artery occlusion (MCAO) and normal controls. The result shows that the brain region with significant signal decline in the MCAO rats was consistent with the occlusion position.
authors.affiliation: Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Nie
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.forename: Shujun
authors.initials: S
authors.lastname: Zhao
authors.forename: Junhua
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Gu
authors.forename: Qunli
authors.initials: Q
authors.lastname: Yao
authors.forename: Jiaojie
authors.initials: J
authors.lastname: Hui
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Gaojun
authors.initials: G
authors.lastname: Teng
authors.forename: Chunjie
authors.initials: C
authors.lastname: Zhao
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
mesh_terms: D000716:Anatomy, Artistic; D000818:Animals; D001271:Atlases as Topic; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D051381:Rats / Q000033:anatomy & histology*