title: Clinical features of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.
abstract: We newly diagnosed 131 patients with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma between 1998 and 2010. We retrospectively studied 124 patients for whom complete clinical data were available at presentation and who had minimally undergone tumour staging by physical examination, computed tomography (CT), bone marrow aspiration, and biopsy. A slight female predominance (men, 58; women, 66) was observed in the study population; the median age was 67 years. The primary locations at presentation were the stomach (38%), orbita (20%), lung (12%), intestinal tract (8%), thyroid gland (6%), others (14%), and unknown (2%). Seventy per cent of patients had localized disease. Of the 124 patients, 14 (11%) had lymph node involvement, and 5 (4%) had bone marrow involvement. Five (4%) patients had both lung and gastric involvement. The 5-year overall survival rate for the 124 patients was 96.1%. The overall vital prognosis was excellent. Moreover, gastro-intestinal fiberscopic examination is essential, especially in cases with lung involvement at presentation.
authors.affiliation: Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Ishii
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Takasaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Ogusa
authors.forename: Yukako
authors.initials: Y
authors.lastname: Hattori
authors.forename: Shiro
authors.initials: S
authors.lastname: Matsuura
authors.forename: Chihiro
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Sachiya
authors.initials: S
authors.lastname: Takemura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed