title: Effect of different quantities of a sugared clear fluid on gastric emptying and residual volume in children: a crossover study using magnetic resonance imaging.
abstract: BACKGROUND
  Gastric emptying in the first 2 h after 7 ml kg(-1) of sugared clear fluid has recently been investigated in healthy children using magnetic resonance imaging (MRI). This study aims to compare gastric volume and emptying half-life during 1 h after 3 or 7 ml kg(-1) sugared clear fluid intake.
  
  
  METHODS
  Fourteen healthy volunteer children aged 11.1 (8.2-12.5) yr were investigated prospectively after administration of 3 and 7 ml kg(-1) diluted raspberry syrup in a randomized order, after overnight fasting (baseline). Gastric content volume (GCV(w)) was assessed with a 1.5 Tesla MRI scanner in a blinded fashion. Data are presented as median (range) and compared using the Wilcoxon test.
  
  
  RESULTS
  Baseline GCV(w) was 0.39 (0.04-1.00) and 0.34 (0.07-0.75) before intake of 3 and 7 ml kg(-1) syrup, respectively (P=0.93). GCV(w) was 0.45 (0.04-1.55)/1.33 (0.30-2.60) ml kg(-1) 60 min after ingestion of 3/7 ml kg(-1) syrup (P=0.002). Thus GCV(w) had declined to baseline after 3 ml kg(-1) (P=0.39) but not after 7 ml kg(-1) (P=0.001) within 60 min. T(1/2) was 20 (10-62)/27 (13-43) min (P=0.73) after 3/7 ml kg(-1).
  
  
  CONCLUSIONS
  In healthy volunteer children, residual GCV(w) 1 h after intake of 3 ml kg(-1) syrup is significantly smaller than that after 7 ml kg(-1) and within the range of baseline.
authors.affiliation: Department of Anaesthesia, University Children's Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland. achim.schmitz@kispi.uzh.ch
authors.forename: A
authors.initials: A
authors.lastname: Schmitz
authors.forename: C J
authors.initials: CJ
authors.lastname: Kellenberger
authors.forename: N
authors.initials: N
authors.lastname: Lochbuehler
authors.forename: M
authors.initials: M
authors.lastname: Fruehauf
authors.forename: R
authors.initials: R
authors.lastname: Klaghofer
authors.forename: H
authors.initials: H
authors.lastname: Fruehauf
authors.forename: M
authors.initials: M
authors.lastname: Weiss
mesh_terms: D000284:Administration, Oral; D002648:Child; D018592:Cross-Over Studies; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004326:Drinking; D005215:Fasting; D005260:Female; D005638:Fruit; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019518:Postprandial Period; D011446:Prospective Studies; D012016:Reference Values; D012115:Residual Volume; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D013270:Stomach / Q000502:physiology*
chemical_list: D019422:Dietary Sucrose