title: [Study on the haemostatic efficiency of composite bio-particles].
abstract: A porous composite particle (CP) was fabricated by the methods of emulsification and cross-link based on chitosan, alginate and collagen protein, and the tranexamic acid-loaded composite particles (TACP) was prepared by immersing the composite particle into the solution of tranexamic acid and by freeze drying. In the hepatic and splenic hemorrhage model of rabbits, CP and TACP were randomly used as haemostatic agents, and the Suxiaozhixuefen (Flashclot) was used as control. The corresponding hemostatic time and bleeding amount were observed respectively. The hemostatic time of CP and Flashclot were (2.48 +/- 0.88) min and (3.07 +/- 0.84) min, respectively, no significant difference was observed. However, the hemostatic time of TACP was (1.90 +/- 0.75) min, which was significantly shorter than that of CP and Flashclot (P < 0.05). In the splenic bleeding model of rabbits, similar results were obtained with these three kinds of hemostatics. These results indicated that the CP based on chitosan, alginate and collagen protein displayed similar hemostatic efficiency to Flashclot. However, the TACP might be one of promising haemostatic powders due to its more excellent hemostatic efficiency.
authors.affiliation: State Key Laboratory of Trauma, Burn and Combined Injury, the 2nd Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. lqs_cq@yahoo.com.cn
authors.forename: Donghong
authors.initials: D
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Gao
authors.forename: Jiatao
authors.initials: J
authors.lastname: Zang
authors.forename: Junlino
authors.initials: J
authors.lastname: Diao
authors.forename: Jiancang
authors.initials: J
authors.lastname: Liu
mesh_terms: D000464:Alginates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006490:Hemostatics; D014148:Tranexamic Acid; D003094:Collagen; D048271:Chitosan