title: A 90-day Feeding Toxicity Study of l-Serine in Male and Female Fischer 344 Rats.
abstract: A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, water intake or urinalysis data. In several of the hematology, serum biochemistry and organ weight parameters, significant changes were observed between some of the treated groups and the controls. All these changes, however, were subtle and lacked any corresponding pathological findings. In addition, the increased or decreased values remained within the range of the historical control values. In fact, histopathological assessment revealed only sporadic and/or spontaneous lesions. In conclusion, the no-observed-adverse-effect-level (NOAEL) for l-Ser was, therefore, determined to be at least a dietary dose of 5.0% (2765.0 mg/kg body weight/day for males and 2905.1 mg/kg body weight/day for females) under the present experimental conditions.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tada
authors.forename: Norio
authors.initials: N
authors.lastname: Yano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Yuzawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ando
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kubo
authors.forename: Akemichi
authors.initials: A
authors.lastname: Nagasawa
authors.forename: Keigi
authors.initials: K
authors.lastname: Chin
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kawamata
authors.forename: Ryosei
authors.initials: R
authors.lastname: Sakai
authors.forename: Norio
authors.initials: N
authors.lastname: Ohashi
authors.forename: Akio
authors.initials: A
authors.lastname: Ogata
authors.forename: Dai
authors.initials: D
authors.lastname: Nakae