title: The vasohibin family: Novel regulators of angiogenesis.
abstract: Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis.
authors.affiliation: Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Sendai 980-8575, Japan. y-sato@idac.tohoku.ac.jp
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sato
mesh_terms: D042501:Angiogenic Proteins / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*
chemical_list: D042501:Angiogenic Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C554361:SVBP protein, human; C493181:VASH1 protein, human; C574858:VASH2 protein, human