title: The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models.
abstract: Fungal infections of the cornea are an important cause of blindness and visual impairment worldwide, with contact lens wear being the main risk factor in the USA and other industrialized countries, and traumatic injury being the main risk factor in developing countries. In this review, we highlight recent advances in the understanding of the host response to Aspergillus and Fusarium species in infected human corneal tissue and in mouse models of fungal keratitis.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Sixto M
authors.initials: SM
authors.lastname: Leal
authors.forename: Eric
authors.initials: E
authors.lastname: Pearlman
mesh_terms: D000818:Animals; D003261:Contact Lenses / Q000009:adverse effects; D003315:Cornea / Q000382:microbiology; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D015821:Eye Infections, Fungal / Q000276:immunology / Q000382:microbiology*; D005670:Fusarium / Q000276:immunology; D006801:Humans; D007634:Keratitis / Q000276:immunology / Q000382:microbiology*; D037181:Lectins, C-Type / Q000502:physiology; D051379:Mice; D009181:Mycoses / Q000150:complications; D051197:Toll-Like Receptor 4 / Q000502:physiology; D000099181:Dectin-1
chemical_list: D016207:Cytokines; D037181:Lectins, C-Type; D051197:Toll-Like Receptor 4; D000099181:Dectin-1