title: Guinea pig models of asthma.
abstract: This unit describes methods for establishing guinea pig models of asthma. Detailed descriptions are provided so that investigators can establish preparations in which bronchoconstriction, airways hyperresponsiveness, cough and airways inflammation can be studied.
authors.affiliation: The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Mazzone
authors.forename: Brendon J
authors.initials: BJ
authors.lastname: Canning
mesh_terms: D000367:Age Factors; D000485:Allergens / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D018893:Bronchoalveolar Lavage / Q000379:methods; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016084:Bronchoconstriction / Q000187:drug effects*; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D003371:Cough / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects; D012018:Reflex / Q000502:physiology; D012121:Respiration, Artificial; D012737:Sex Factors; D013048:Specimen Handling / Q000379:methods; D014132:Trachea / Q000187:drug effects
chemical_list: D000485:Allergens; D018927:Anti-Asthmatic Agents; D016085:Bronchoconstrictor Agents; D004791:Enzyme Inhibitors