title: [Epidemiology and clinical features in diabetic patients with invasive infections treated at the Clinical Hospital of Infectious Diseases of Iaşi, Romania, between 2008-2010].
abstract: Infections in the diabetic population can be severe and life threatning at least for two reasons: clinical signs are often torpid, masqued by chronical complications of diabetes leading to late recognition and medical adresability and also because of the inability to control established infection due to complex cell-mediated and humoral immunity deffects. The aim of the study was to evaluate the etiology, clinical features and outcome in diabetic patients with invazive disease.
  
  
  METHODS
  A retrospective study was conducted between January 2008 and December 2010 at The Clinical Hospital of Infectious Diseases Iaşi among 75 diabetic patients with sepsis of microbiologically confirmed etiology (positive cultures from normally sterile sites) and sepsis with clinically suspected etiology (positive cultures from pus). Cases with positive urocultures and coprocultures only, were excluded.
  
  
  RESULTS
  From 75 diabetics, 56% were males, 90,7% being over 50 years. Severe cases of sepsis (33/75, 44%) were associated more often with insulin-treated diabetes than non-insulin treated group (40% vs. 4%, p<0,005) probably because of multiple comorbidities associated as suggested by a high Charlson score (6,09 vs. 4,09, p<0,05). There were 64 cases with confirmed etiology and 11 cases with clinically suspected etiology. Staphylococcus aureus and Escherichia coli were the most common agents isolated, being involved in 16 (21,3%) cases each, followed by coagulase negative Staphylococci (14/18,66%), Enterococcus spp.(6/8%), group B Streptococcus (3/4%), Streptococcus pneumoniae, Enterobacter spp., Salmonella spp. (2/2,66% each), Aerococcus viridans, Streptococcus equi, Klebsiella pneumoniae, Neisseria meningitidis, Sphyngomonas paucimobilis, Pseudomonas aeruginosa, Proteus mirabilis (1/1,33%). Multiple septic disseminations occured in 17(22,6%) cases and meningeal involvment was doccumented in 10(15,6%) cases. Meticillin resistance was noted in 53,3% for invasive isolates of S. aureus. Among 16 invazive strains of E. coli, 25% were resistant to 3rd generation cephalosporins, 17% to ciprofloxacin and 6,6% to aminoglycosides and colimycin. There were no E. coli strains resistant to imipenem, piperacillin-tazobactam and aztreonam. The mean mortality rate was 14,66%.
  
  
  CONCLUSIONS
  The high level of resistance of S. aureus and E. coli to commonly used antibiotics and meningeal involvement imposes a multidisciplinary approach of the diabetic patient. Proper knowledge of the pathogers involved in the potential invazive diseases is an important tool for successful treatment with appropriate empirical broad-spectrum antimicrobial agents.
authors.affiliation: Facultatea de Medicină, Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi.
authors.forename: Cristina Gabriela
authors.initials: CG
authors.lastname: Petrovici
authors.forename: Carmen
authors.initials: C
authors.lastname: Dorobăt
authors.forename: Codrina
authors.initials: C
authors.lastname: Bejan
authors.forename: Gabriela
authors.initials: G
authors.lastname: Juganariu
authors.forename: Eliza
authors.initials: E
authors.lastname: Simiraş
authors.forename: Olga
authors.initials: O
authors.lastname: Filip
authors.forename: V
authors.initials: V
authors.lastname: Luca
authors.forename: Egidia
authors.initials: E
authors.lastname: Miftode
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality*; D048909:Diabetes Complications / Q000175:diagnosis / Q000401:mortality*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000401:mortality*; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D012720:Severity of Illness Index; D015996:Survival Rate