title: Frequent association of thrombophilia in cerebral venous sinus thrombosis.
abstract: Thrombophilia is frequently associated with venous thromboembolism (VTE) including cerebral venous sinus thrombosis (CVST). The possibility of thrombophilia was examined in 12 patients with CSVT diagnosed in the past 9 years. Thrombophilia due to abnormalities in antithrombin (AT), protein C (PC), or protein S (PS) or antiphospholipid syndrome (APS) was evaluated. Nine patients with abnormally decreased AT, PC or PS and one patient with APS were examined. Of the nine patients examined by a gene analysis of AT, PC, or PS, one had a congenital AT deficiency, one had a congenital PC deficiency, and two had congenital PS deficiencies including a novel mutant (Gly189Ala). AT, PC and PS levels were all decreased in one patient, PS level was decreased in three patients, and AT level was decreased in one patient at the onset of CVST, but these concentrations improved after treatment. CVST is frequently associated with thrombophilia and a transient decrease in AT, PC or PS may be a causal factor.
authors.affiliation: Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ikejiri
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shindo
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ii
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tomimoto
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Abe
authors.forename: Kaname
authors.initials: K
authors.lastname: Nakatani
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000097:blood; D020152:Antithrombin III Deficiency / Q000150:complications / Q000235:genetics; D002460:Cell Line; D002522:Chlorocebus aethiops; D003392:Cranial Sinuses; D006224:Cricetinae; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D020151:Protein C Deficiency / Q000150:complications / Q000235:genetics; D018455:Protein S Deficiency / Q000150:complications / Q000235:genetics; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D054556:Venous Thromboembolism / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D017152:Antibodies, Antiphospholipid