title: Cell transplantation in surgical treatment of familial adenomatous polyposis coli.
abstract: We developed a method of surgical treatment of familial adenomatous polyposis coli giving an opportunity to prevent the growth of new polyps in the preserved part of the rectum and consisting in transplantation of fetal cells of the epithelial origin into the rectum wall after mucosectomy. Since the rectum is partially preserved, ileorectal anastomosis can be formed after colectomy, which preserves natural bowel passage. Complex examination 4 weeks after surgery revealed the formation of normal rectal mucosa. No new polyps were detected in the rectum 1-3 years after surgery.
authors.affiliation: Research Center of Coloproctology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Vorobyov
authors.forename: A M
authors.initials: AM
authors.lastname: Kuzminov
authors.forename: D V
authors.initials: DV
authors.lastname: Vyshegorodtsev
authors.forename: L L
authors.initials: LL
authors.lastname: Kapuller
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods; D017690:Cell Transplantation / Q000379:methods*; D003082:Colectomy; D005260:Female; D005753:Gastric Mucosa / Q000502:physiology; D006801:Humans; D008297:Male; D011127:Polyps / Q000473:pathology / Q000601:surgery; D012007:Rectum / Q000473:pathology / Q000601:surgery*; D055815:Young Adult