title: Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives.
abstract: Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC(50)  ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.
authors.affiliation: Departamento de Química, Universidade Federal de Juiz de Fora, Campus Universitário s/n, Martelos, Juiz de Fora, MG, Brazil.
authors.forename: Lucas Lopardi
authors.initials: LL
authors.lastname: Franco
authors.forename: Mauro Vieira
authors.initials: MV
authors.lastname: de Almeida
authors.forename: Luiz Francisco Rocha
authors.initials: LF
authors.lastname: E Silva
authors.forename: Pedro Paulo Ribeiro
authors.initials: PP
authors.lastname: Vieira
authors.forename: Adrian Martin
authors.initials: AM
authors.lastname: Pohlit
authors.forename: Marcelo Siqueira
authors.initials: MS
authors.lastname: Valle
mesh_terms: D000096:Acetone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy; D010545:Peroxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship; D045568:Tetraoxanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D010545:Peroxides; D045568:Tetraoxanes; D000096:Acetone