title: [Adjuvant treatments in breast cancer: interest of completion of axillary dissection in case of micrometastases or isolated tumor cells in sentinel lymph node].
abstract: Prognostic signification of micrometastases ou isolated tumor cells (ITC) has not yet been clearly precised. Management of the axilla in case of micrometastases or ITC depends on the local pratices: no surgical completion or axillary lymph node dissection (ALND). Axillary lymph node status is the most important prognostic factor in patients with breast cancer; morbidity of ALND is now well known whereas its therapeutic benefit has not been demonstrated. This study is based on a retrospective database of 1375 patients who underwent sentinel node (SN) biopsy for breast cancer. In case of micrometastase or ITC in SN with completion axillary dissection, we examined if non-sentinel lymph node status has changed the indications of adjuvant treatments (chimiotherapy or radiotherapy). The results of our study show that non-sentinel lymph node status modify systemic therapy for a very few patients (less than 4% concerning chimiotherapy and less than 15% concerning radiotherapy).
authors.affiliation: Centre Léon-Bérard, 28, Lyon, France. caroline.schmitt@hotmail.fr
authors.forename: Caroline
authors.initials: C
authors.lastname: Schmitt
authors.forename: Catherine
authors.initials: C
authors.lastname: Bouteille
authors.forename: Christelle
authors.initials: C
authors.lastname: Faure
authors.forename: Hervé
authors.initials: H
authors.lastname: Mignotte
authors.forename: Olivier
authors.initials: O
authors.lastname: Tredan
authors.forename: Thomas
authors.initials: T
authors.lastname: Bachelot
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guastalla
authors.forename: Antoine
authors.initials: A
authors.lastname: Arnaud
authors.forename: Isabelle
authors.initials: I
authors.lastname: Treilleux
authors.forename: Nicolas
authors.initials: N
authors.lastname: Carrabin
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D047368:Tumor Burden