title: In search of proteins that are important for synaptic functions in Drosophila visual system.
abstract: This is the second of two reviews that include some of the studies we, members of the Pak laboratory and collaborators, did from 2000 to 2010 on the mutants that affect synaptic transmission in the Drosophila visual system. Of the five mutants we discuss, two turned out to also play roles in the larval neuromuscular junction. This review complements the one on phototransduction to give a fairly complete account of what we focused on during the 10-year period, although we also did some studies on photoreceptor degeneration in the early part of the decade. Besides showing the power of using a genetic approach to the study of synaptic transmission, the review contains some unexpected results that illustrate the serendipitous nature of research.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Eunju
authors.initials: E
authors.lastname: Kim
authors.forename: Shikoh
authors.initials: S
authors.lastname: Shino
authors.forename: Jaeseung
authors.initials: J
authors.lastname: Yoon
authors.forename: Hung-Tat
authors.initials: HT
authors.lastname: Leung
mesh_terms: D000818:Animals; D018118:Chloride Channels; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000266:history / Q000378:metabolism*; D005136:Eye Proteins / Q000235:genetics / Q000266:history / Q000378:metabolism*; D034541:Heterogeneous-Nuclear Ribonucleoprotein Group F-H; D049673:History, 20th Century; D049674:History, 21st Century; D007473:Ion Channels; D055537:Light Signal Transduction / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases; D013569:Synapses / Q000235:genetics / Q000502:physiology*; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D014795:Visual Pathways / Q000502:physiology*
chemical_list: D018118:Chloride Channels; D029721:Drosophila Proteins; D005136:Eye Proteins; D034541:Heterogeneous-Nuclear Ribonucleoprotein Group F-H; D007473:Ion Channels; D019869:Phosphatidylinositol 3-Kinases; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; C439908:FUS protein, Drosophila; C475684:TrpA1 protein, Drosophila; C446763:ort protein, Drosophila