title: Severe hypernatremia following treatment of the syndrome of inappropriate antidiuretic hormone secretion.
abstract: Treatment strategies for hyponatremia such as hypertonic saline, normal saline with furosemide, urea, fluid restriction and demeclocycline are well established. However, these treatment modalities may themselves be associated with life-threatening complications. An important complication is rapid correction of hyponatremia with its consequent serious neurologic deficits and death. An unrecognized complication is the development of severe hypernatremia as a result of strict fluid restriction and concomitant excessive free water excretion from prolonged outpatient demeclocycline therapy. The authors report a case of a patient with hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion who developed severe hypernatremia as a result of rigid fluid restriction and demeclocycline therapy.
authors.affiliation: Department of Medicine, University of Texas Health Science Center; and Texas Diabetes Institute, San Antonio, TX 78229-3990, USA.
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Soudan
authors.forename: Wajeh
authors.initials: W
authors.lastname: Qunibi
mesh_terms: D000368:Aged; D003707:Demeclocycline / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000175:diagnosis* / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis* / Q000628:therapy*; D012720:Severity of Illness Index; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D003707:Demeclocycline