title: Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease.
abstract: BACKGROUND
  Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD).
  
  
  OBJECTIVE
  To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD.
  
  
  METHODS
  From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma.
  
  
  RESULTS
  Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age >65 years and higher serum sTREM-1 level were associated with worse 6-month survival.
  
  
  CONCLUSIONS
  In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei.
authors.forename: C-C
authors.initials: CC
authors.lastname: Shu
authors.forename: L-N
authors.initials: LN
authors.lastname: Lee
authors.forename: M-F
authors.initials: MF
authors.lastname: Wu
authors.forename: C-H
authors.initials: CH
authors.lastname: Lee
authors.forename: J-T
authors.initials: JT
authors.lastname: Wang
authors.forename: J-Y
authors.initials: JY
authors.lastname: Wang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Yu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016009:Chi-Square Distribution; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009165:Mycobacterium Infections, Nontuberculous / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D009162:Mycobacterium avium / Q000302:isolation & purification; D019909:Mycobacterium kansasii / Q000302:isolation & purification; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D011971:Receptors, Immunologic / Q000097:blood*; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology; D013624:Taiwan; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D007371:Interferon-gamma; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide