title: Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension.
abstract: OBJECTIVE
  To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes to adverse reactions via a questionnaire.
  
  
  METHODS
  Fifty-two Japanese patients with glaucoma or ocular hypertension were enrolled. Iridial, eyelid, and eyelash photographs were taken before and at 6 months after bimatoprost treatment. Increase in eyelid pigmentation, iridial pigmentation, eyelash growth and bristle, and vellus hair of the lid was assessed from the photographs. Questionnaires completed by patients provided insight into their subjective judgment of adverse reactions.
  
  
  RESULTS
  Increase in eyelash bristle (53.8%), iris pigmentation (50.0%), eyelash growth (46.2%), vellus hair of the lid (40.4%), and eyelid pigmentation (7.7%) was evident after bimatoprost treatment. The objective and subjective assessments were in agreement in terms of increase in eyelash bristle, eyelash growth, and increase in vellus hair of the lid.
  
  
  CONCLUSIONS
  Most patients were conscious of these adverse reactions. Before administering bimatoprost, sufficient explanation of potential adverse reactions should be provided; after initiating treatment, careful observation is required.
authors.affiliation: Inouye Eye Hospital, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Inoue
authors.forename: Minako
authors.initials: M
authors.lastname: Shiokawa
authors.forename: Michitaka
authors.initials: M
authors.lastname: Sugahara
authors.forename: Risako
authors.initials: R
authors.lastname: Higa
authors.forename: Masato
authors.initials: M
authors.lastname: Wakakura
authors.forename: Goji
authors.initials: G
authors.lastname: Tomita