title: Pre-treatment with curcumin enhances plasma concentrations of losartan and its metabolite EXP3174 in rats.
abstract: The study was carried out in the Wistar rats to investigate the effect of curcumin pre-treatment on the pharmacokinetics of the hypertension-treating drug losartan and its metabolite EXP3174 following single oral administration. In the treatment group, rats were gavaged with losartan 10 mg/kg after repeat oral doses of curcumin (100 mg/kg, for 7 d), while rats in the control group were administrated only with the same dose losartan. The results showed that curcumin significantly increased the plasma concentrations of losartan and its metabolite EXP3174. The present study implicated the existence of herb-drug interaction between curcumin and losartan, and further evaluation of the possible interaction during curcumin administration needs to be considered.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: An-Chang
authors.initials: AC
authors.lastname: Liu
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Xing
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.forename: Fu-Ying
authors.initials: FY
authors.lastname: Du
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D007093:Imidazoles / Q000097:blood*; D019808:Losartan / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D053719:Tandem Mass Spectrometry; D013777:Tetrazoles / Q000097:blood*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000975:Antioxidants; D007093:Imidazoles; D013777:Tetrazoles; C066026:losartan carboxylic acid; D003474:Curcumin; D019808:Losartan