title: One year after endoscopic sinus surgery in polyposis: asthma, olfaction, and quality-of-life outcomes.
abstract: OBJECTIVE
  Nasal polyposis is a disease known to be associated with asthma. The long-term effects of surgical treatment on lower airways have not been sufficiently studied.
  
  
  METHODS
  One-year follow-up of a double-blind, randomized, placebo-controlled study.
  
  
  METHODS
  The study was conducted at the Karolinska University Hospital, Stockholm, Sweden.
  
  
  METHODS
  Fifty-one patients, age 18 years or older, with nasal polyposis and asthma were evaluated 1 year after endoscopic sinus surgery (ESS). Outcomes included dyspnea/cough scores, mean daily peak expiratory flow rate, spirometry, butanol test, olfaction scores, peak nasal inspiratory flow, polyp scores, and health-related quality of life (SF-36).
  
  
  RESULTS
  The short-term postsurgery improvements in asthma symptom scores, daily peak expiratory flow rate, all nasal parameters including olfaction, and quality-of-life scores were generally maintained 1 year after ESS.
  
  
  CONCLUSIONS
  Endoscopic sinus surgery had beneficial long-term effects on asthma, olfaction, and quality of life in patients with nasal polyposis. This is the first study to show long-term benefits of ESS on butanol tests in patients with nasal polyposis.
authors.affiliation: Department of Clinical Science, Intervention and Technology, Division of Otorhinolaryngology, Karolinska Institutet, Stockholm, Sweden. anders.ehnhage@ki.se
authors.forename: Anders
authors.initials: A
authors.lastname: Ehnhage
authors.forename: Petter
authors.initials: P
authors.lastname: Olsson
authors.forename: Karl-Gustav
authors.initials: KG
authors.lastname: Kölbeck
authors.forename: Maria
authors.initials: M
authors.lastname: Skedinger
authors.forename: Pär
authors.initials: P
authors.lastname: Stjärne
mesh_terms: D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000517:prevention & control*; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000503:physiopathology / Q000601:surgery*; D010256:Paranasal Sinuses / Q000601:surgery*; D010919:Placebos; D011788:Quality of Life; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D012903:Smell / Q000502:physiology*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D010919:Placebos