title: Synthesis and evaluation of antioxidant properties of novel 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(2-arylmethylene amino) acetamides and 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl) acetamides-I.
abstract: Our approach was to synthesize and examine the antioxidant properties of some new 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(2-arylmethyleneamino) acetamide (1-18) and 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl)acetamide (1t-18t) derivatives. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O-deethylase activities (EROD assay) were determined. The free radical scavenging properties of the compounds were also examined in vitro determining the interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. The compounds showed significant effects in the above tests.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Tandogan, Ankara, Turkey. kilcigil@pharmacy.ankara.edu.tr
authors.forename: Gülgün
authors.initials: G
authors.lastname: Ayhan-Kılcıgil
authors.forename: Selen
authors.initials: S
authors.lastname: Gürkan
authors.forename: Tülay
authors.initials: T
authors.lastname: Coban
authors.forename: Elçin Deniz
authors.initials: ED
authors.lastname: Ozdamar
authors.forename: Benay
authors.initials: B
authors.lastname: Can-Eke
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010851:Picrates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000975:Antioxidants; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D053778:Thiazolidines; C004931:1,1-diphenyl-2-picrylhydrazyl