title: Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat.
abstract: Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@ Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterized by an admixture of malignant epithelial and nonepithelial elements. The carcinomatous components represented a type of endometrial carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells. Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were characterized by multifocal proliferation of severe atypical cells with cartilage matrix and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous components were observed, and many tumor cells in the solid lesion showed immunohistochemical reactivity with both cytokeratin and vimentin. Based on these findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Takami
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Umemura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hibi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishii
authors.forename: Toshiya
authors.initials: T
authors.lastname: Okamura
authors.forename: Masako
authors.initials: M
authors.lastname: Tasaki
authors.forename: Tomoki
authors.initials: T
authors.lastname: Inoue
authors.forename: Yuta
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Meilan
authors.initials: M
authors.lastname: Jin
authors.forename: Young-Man
authors.initials: YM
authors.lastname: Cho
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Nishikawa