title: Serum levels of 25-hydroxyvitamin D, oral health and chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To evaluate the associations of serum 25-Hydroxyvitamin D [25(OH)D] levels with periodontal health and chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  We conducted a case-control study of 193 COPD patients and 181 controls. Their periodontal status and lung function were examined, and serum 25(OH)D levels were measured.
  
  
  RESULTS
  Mean serum 25(OH)D concentrations were significantly lower in the COPD group than in the controls (32.1 versus 35.8 nmol/l; p = 0.002). Serum 25(OH)D concentrations were positively correlated with lung function among non-smokers and negatively correlated with plaque index (PLI) among former smokers. After adjustment for age, gender, body mass index, season and smoking status, periodontal indexes were significantly associated with serum 25(OH)D concentrations (number of remaining teeth among all groups; probing depth, clinical attachment level, bleeding index, PLI and alveolar bone loss among COPD group). Lower serum 25(OH)D concentrations were significantly associated with an increased risk of COPD among former smokers (Odd ratio 4.11; 95% confidence interval 1.47-11.5; p = 0.007) after adjustment for periodontal indexes and other variables.
  
  
  CONCLUSIONS
  Lower serum 25(OH)D concentrations were significantly associated with poor periodontal health and an increased risk of COPD.
authors.affiliation: Department of Stomatology, Beijing ChaoYang Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Song
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zuomin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000097:blood / Q000150:complications / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017622:Periodontal Attachment Loss / Q000097:blood / Q000150:complications / Q000378:metabolism*; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000150:complications / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications / Q000378:metabolism*; D013147:Spirometry; D018709:Statistics, Nonparametric; D014797:Vital Capacity; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D