title: [Clinical re-evaluation of effects of different treatments to prevent from phlebitis induced by Chansu injection].
abstract: OBJECTIVE
  To re-evaluate the effects of different treatments to prevent from phlebitis induced by Chansu injection.
  
  
  METHODS
  Patients treated with Chansu injection were divided randomly into 4 groups with 50 per group, control group, the magnesium sulfate group, phentolaminum group, and anisodamine group. Patients in the control group only received the routine nursing treatment, and patients in the various experiment group received different interventions. The comparison was made in the morbidity and the starting time of occurrence of phlebitis, the severity of pain, duration of pain.
  
  
  RESULTS
  The morbidity of phlebitis was 8%, 8%, 6% respectively. The starting time of phlebitis occurrence was (21 +/- 9.31) , (22.34 +/- 10.15), (20.19 +/- 11.23) h, respectively. The NRS of pain was (4. 15 +/- 1.03), (3.26 +/- 1.17), (4.32 +/- 1.36), respectively. The duration time of pain was (4.05 +/- 1.21), (3.37 +/- 1.17), (3.19 +/- 1.67) d, respectively. In control group, the morbidity of phlebitis, the starting time of occurrence of phlebitis, the severity of pain, duration of pain was 24%, (17 +/- 6.32) h, (6.58 +/- 1.29), (5.32 +/- 1.12) d, respectively. As compared with the control group, a significance difference was found between every group in three test groups and control group respectively (P<0.05).
  
  
  CONCLUSIONS
  The morbidity and the starting time of occurrence of phlebitis, the severity of pain, duration of pain was significantly reduced respectively by external appication of magnesium sulfate, anisodamine, and intravenous drip infusion of phentolaminum.
authors.affiliation: Post-doctoral Station of China Academy of Chinese Medical Sciences, Beijing 100700, China. drzhyubin@sina.com
authors.forename: Yubin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhe
authors.initials: Z
authors.lastname: Hao
authors.forename: Hongdan
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002018:Bufanolides / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010646:Phentolamine / Q000008:administration & dosage; D010689:Phlebitis / Q000139:chemically induced* / Q000517:prevention & control; D012991:Solanaceous Alkaloids / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002018:Bufanolides; D012991:Solanaceous Alkaloids; C095591:chan su; C003922:anisodamine; D008278:Magnesium Sulfate; D010646:Phentolamine