title: Synthesis of extended, π-conjugated isoindolin-1-ones.
abstract: The synthesis and characterization of extended, conjugated molecules containing isoindolinone units was explored. Nucleophilic cyclizations between an amide and an alkyne were found to be an efficient method of producing the desired isoindolin-1-ones in high yields. A variety of derivatives were synthesized, demonstrating that a number of structural alterations could be made while maintaining good regio- and stereospecificity in the cyclized product.
authors.affiliation: Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick, Canada E3B 5A3.
authors.forename: Alex
authors.initials: A
authors.lastname: Bubar
authors.forename: Paula
authors.initials: P
authors.lastname: Estey
authors.forename: Michael
authors.initials: M
authors.lastname: Lawson
authors.forename: Sara
authors.initials: S
authors.lastname: Eisler
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D054833:Isoindoles