title: Stoffenmanager Nano version 1.0: a web-based tool for risk prioritization of airborne manufactured nano objects.
abstract: Stoffenmanager Nano (version 1.0) is a risk-banding tool developed for employers and employees to prioritize health risks occurring as a result of exposure to manufactured nano objects (MNOs) for a broad range of worker scenarios and to assist implementation of control measures to reduce exposure levels. In order to prioritize the health risks, the Stoffenmanager Nano combines the available hazard information of a substance with a qualitative estimate of potential for inhalation exposure. The development of the Stoffenmanager Nano started with a review of the available literature on control banding. Input parameters for the hazard assessment of MNOs were selected based on the availability of these parameters in, for instance, Safety Data Sheets or product information sheets. The conceptual exposure model described by Schneider et al. (2011) was used as the starting point for exposure banding. During the development of the Stoffenmanager Nano tool, the precautionary principle was applied to deal with the uncertainty regarding hazard and exposure assessment of MNOs. Subsequently, the model was converted into an online tool (http://nano.stoffenmanager.nl), tested, and reviewed by a number of companies. In this paper, we describe the Stoffenmanager Nano. This tool offers a practical approach for risk prioritization in exposure situations where quantitative risk assessment is currently not possible. Updates of this first version are anticipated as more data become available in the future.
authors.affiliation: TNO Innovation for Life, Utrechtseweg 48, PO Box 350, 3700 AJ Zeist, The Netherlands. birgit.vanduuren@tno.nl
authors.forename: Birgit
authors.initials: B
authors.lastname: Van Duuren-Stuurman
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Vink
authors.forename: Koen J M
authors.initials: KJ
authors.lastname: Verbist
authors.forename: Henri G A
authors.initials: HG
authors.lastname: Heussen
authors.forename: Derk H
authors.initials: DH
authors.lastname: Brouwer
authors.forename: Dinant E D
authors.initials: DE
authors.lastname: Kroese
authors.forename: Maikel F J
authors.initials: MF
authors.lastname: Van Niftrik
authors.forename: Erik
authors.initials: E
authors.lastname: Tielemans
authors.forename: Wouter
authors.initials: W
authors.lastname: Fransman
mesh_terms: D000395:Air Pollutants, Occupational / Q000145:classification* / Q000592:standards / Q000633:toxicity; D000465:Algorithms; D006801:Humans; D007221:Industry / Q000592:standards*; D019570:Inhalation Exposure / Q000009:adverse effects / Q000517:prevention & control* / Q000706:statistics & numerical data; D020407:Internet; D008954:Models, Biological; D049329:Nanostructures / Q000145:classification* / Q000633:toxicity; D016273:Occupational Exposure / Q000009:adverse effects / Q000517:prevention & control* / Q000706:statistics & numerical data; D010316:Particle Size; D012134:Respiratory Protective Devices; D018570:Risk Assessment / Q000379:methods; D012308:Risk Management / Q000379:methods*; D012984:Software
chemical_list: D000395:Air Pollutants, Occupational