title: Long-term effects of systemic cancer treatment on DNA oxidative damage: the potential for targeted therapies.
abstract: The main pathological consequence of free radical exposure is DNA damage, which is known to induce cell transformation and to facilitate important mutations in cancer progression. It is a matter of intense discussion whether the drug-induced production of free radicals limits the therapeutic efficacy of chemotherapeutics and enhances their toxicity or whether they may be enhanced to provoke cancer cell apoptosis. This paper reviews essential molecular processes to better understand the controversial role of free radicals in cancer development and progression, and discusses some novel therapeutic strategies based on oxidative stress induction and prevention.
authors.affiliation: Department of Oncology, Complejo Hospitalario de Jaen, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Vera-Ramirez
authors.forename: McArmen
authors.initials: M
authors.lastname: Ramirez-Tortosa
authors.forename: Patricia
authors.initials: P
authors.lastname: Perez-Lopez
authors.forename: Sergio
authors.initials: S
authors.lastname: Granados-Principal
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species