title: Molecular study of the PCA3 gene: genotypic analysis of PCA3 polymorphism -845G>A and metastatic prostate cancer.
abstract: OBJECTIVE
  The prostate cancer gene 3 (PCA3) is a prostate-specific, non-protein-coding RNA. It is overexpressed in prostate cancer compared with the normal prostate and has a negative expression in other tissues. This case-control study sought to analyze the frequency of the polymorphism PCA3 -845 G>A in participants without prostate cancer and patients with metastatic prostate cancer.
  
  
  RESULTS
  Carriers of GA and AA genotype had a higher risk for metastatic prostate cancer (odds ratio [OR] for genotype GA, 1.79 [95% confidence interval (CI), 1.14-2.29]; p=0.007; OR for genotype AA, 2.38 [95% CI, 1.22-4.65]; p=0.006). Furthermore, the recessive model showed that A allele carriers have an increased risk for developing metastatic prostate cancer (OR, 1.91 [95% CI, 1.26-2.90]; p=0.001).
  
  
  CONCLUSIONS
  These results suggest a link between PCA3 and metastatic prostate cancer. The evaluation of individual genetic profiles, according to the PCA3 -845 G>A polymorphism, may elucidate the function of this gene and the mechanisms involved in its regulation and role in prostate cancer.
authors.affiliation: Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Porto, Portugal.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fontenete
authors.forename: Augusto
authors.initials: A
authors.lastname: Nogueira
authors.forename: Francisco
authors.initials: F
authors.lastname: Pina
authors.forename: Francisco
authors.initials: F
authors.lastname: Lobo
authors.forename: Avelino
authors.initials: A
authors.lastname: Fraga
authors.forename: Fernando
authors.initials: F
authors.lastname: Calais da Silva
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011110:Polymorphism, Genetic; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; C479341:prostate cancer antigen 3, human