title: The effect of total abdominal hysterectomy on serum anti-Müllerian hormone levels: a pilot study.
abstract: OBJECTIVE
  To evaluate the effect of hysterectomy on levels of serum anti-Müllerian hormone (AMH), an indicator of ovarian reserve.
  
  
  METHODS
  Twenty-two premenopausal women between 40 and 50 years of age who underwent total abdominal hysterectomy for uterine leiomyoma were enrolled to the patient group and unaffected women in a similar age range constituted the control group. Samples were collected preoperatively and at the 4th month postoperatively from the patients and two times at 4 months apart from the controls. Serum AMH levels were detected with enzyme-linked immunosorbent assay and compared within each group and between groups.
  
  
  RESULTS
  Baseline serum AMH values were similar (1.46 ± 2.02 ng/ml for the hysterectomy group and 1.53 ± 1.82 ng/ml for the control group, p = 0.73). Serum AMH levels at month 4 decreased to 0.62 ± 0.9 ng/ml and 1.26 ± 1.78 ng/ml for hysterectomy patients and controls, respectively (p = 0.001 and < 0.001, respectively). Although the percentage median decrease was higher in hysterectomized women (58.9% vs. 28.5%), this was statistically insignificant (p = 0.26).
  
  
  CONCLUSIONS
  Although not statistically significant, our study demonstrated that total abdominal hysterectomy causes 30% more loss of ovarian reserve in addition to the effects of aging. Further research on larger populations is needed to confirm our results and to apply them in clinical practice.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School of Ankara University, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Atabekoğlu
authors.forename: S
authors.initials: S
authors.lastname: Taşkin
authors.forename: K
authors.initials: K
authors.lastname: Kahraman
authors.forename: A
authors.initials: A
authors.lastname: Gemici
authors.forename: E A
authors.initials: EA
authors.lastname: Taşkin
authors.forename: B
authors.initials: B
authors.lastname: Ozmen
authors.forename: B
authors.initials: B
authors.lastname: Berker
authors.forename: M
authors.initials: M
authors.lastname: Sönmezer
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism*; D010865:Pilot Projects; D017697:Premenopause; D018709:Statistics, Nonparametric; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D054304:Anti-Mullerian Hormone