title: [Multimodal laryngeal preservation: current data-based opinion].
abstract: This article presents the current data and discussion on multimodal laryngeal preservation strategies in advanced laryngeal/hypopharyngeal carcinoma. Principally a distinction is made between simultaneous and induction chemoradiation protocols. In terms of late toxicity and related functional limitations, induction protocols are far superior to simultaneous platinum-based chemoradiation. Currently, the individual response to the first cycle of (short) induction chemotherapy appears to be the most reliable clinical marker for making treatment decisions, and this is under clinical investigation. No standard multimodal therapeutic alternative to laryngectomy exists; therefore, at this time multimodal strategies should only be carried out within the framework of clinical trials.
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsklinik Leipzig, Liebigstr. 10-14, 04103, Leipzig, Deutschland. andreas.dietz@medizin.uni-leipzig.de
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.forename: A
authors.initials: A
authors.lastname: Boehm
authors.forename: G
authors.initials: G
authors.lastname: Wichmann
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
authors.forename: S
authors.initials: S
authors.lastname: Dietzsch
authors.forename: M
authors.initials: M
authors.lastname: Fuchs
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D059351:Organ Sparing Treatments / Q000639:trends*; D018579:Patient Selection; D020266:Radiotherapy, Conformal / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents