title: Preventive effects of zinc against psychological stress-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.
abstract: Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.
authors.affiliation: Department of Military Hygiene, Second Military Medical University, Shanghai, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jianxin
authors.initials: J
authors.lastname: Qian
authors.forename: Xinmin
authors.initials: X
authors.lastname: Chen
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Shen
authors.forename: Liping
authors.initials: L
authors.lastname: Tao
authors.forename: Hongxia
authors.initials: H
authors.lastname: Li
authors.forename: Haihong
authors.initials: H
authors.lastname: Qin
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D019587:Dietary Supplements; D004920:Erythropoiesis / Q000187:drug effects* / Q000502:physiology; D005978:Glutathione; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*; D017967:Zinc Compounds / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; D008315:Malondialdehyde; C016837:zinc chloride; D007501:Iron; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc; D003345:Corticosterone