title: A membrane-integrated fermentation reactor system: its effects in reducing the amount of sub-raw materials for D-lactic acid continuous fermentation by Sporolactobacillus laevolacticus.
abstract: Continuous fermentation by retaining cells with a membrane-integrated fermentation reactor (MFR) system was found to reduce the amount of supplied sub-raw material. If the amount of sub-raw material can be reduced, continuous fermentation with the MFR system should become a more attractive process for industrialization, due to decreased material costs and loads during the refinement process. Our findings indicate that the production rate decreased when the amount of the sub-raw material was reduced in batch fermentation, but did not decrease during continuous fermentation with Sporolactobacillus laevolacticus. Moreover, continuous fermentation with a reduced amount of sub-raw material resulted in a productivity of 11.2 g/L/h over 800 h. In addition, the index of industrial process applicability used in the MFR system increased by 6.3-fold as compared with the conventional membrane-based fermentation reactor previously reported, suggesting a potential for the industrialization of this D-lactic acid continuous fermentation process.
authors.affiliation: New Frontiers Research Laboratories, Toray Industries, Inc., Kamakura, Kanagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mimitsuka
authors.forename: Kyungsu
authors.initials: K
authors.lastname: Na
authors.forename: Ken
authors.initials: K
authors.lastname: Morita
authors.forename: Hideki
authors.initials: H
authors.lastname: Sawai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minegishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Henmi
authors.forename: Katsushige
authors.initials: K
authors.lastname: Yamada
authors.forename: Sakayu
authors.initials: S
authors.lastname: Shimizu
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yonehara
mesh_terms: D056449:Bacillales / Q000378:metabolism*; D019149:Bioreactors / Q000382:microbiology*; D005285:Fermentation; D019344:Lactic Acid / Q000096:biosynthesis*; D008567:Membranes, Artificial; D013997:Time Factors; D015003:Yeasts / Q000737:chemistry
chemical_list: D008567:Membranes, Artificial; D019344:Lactic Acid