title: Hydroxypropylated distarch phosphate versus unmodified tapioca starch: fat oxidation and endurance in C57BL/6J mice.
abstract: An RS4-type resistant starch is a chemically modified starch that shows reduced availability in comparison to the corresponding unmodified starch. Hydroxypropylated distarch phosphate (HDP) is an RS4-type resistant starch that increases energy expenditure and prevents high-fat diet-induced obesity through increased hepatic fatty acid oxidation. The aim of this study was to clarify the acute effects of HDP from tapioca starch (HPdTSP) on physical performance in mice. Male C57BL/6J mice were used to examine the effects of a single administration of 2 mg/g body weight HPdTSP or unmodified tapioca starch (TS) on postprandial responses in serum metabolic parameters, running endurance capacity on a treadmill, whole-body energy metabolism during exercise, activity of enzymes involved in fatty acid oxidation, liver and gastrocnemius muscle glycogen content, and serum glucose, insulin, non-esterified fatty acid, lactate, and triglyceride levels after exercise. Running time to fatigue was significantly greater in HPdTSP mice than in TS mice. Furthermore, HPdTSP maintained higher fat oxidation and this was associated with a greater activity of enzymes in fatty acid oxidation in the muscle during exercise. The blood lactate and serum insulin levels after exercise was significantly lower in HPdTSP mice than in TS mice. Liver glycogen was significantly higher in HPdTSP mice than in TS mice. These results suggest that acute oral administration of the RS4-type resistant starch, HPdTSP, maintained higher fat oxidation and reduced liver glycogen consumption during exercise and increased running endurance capacity in mice.
authors.affiliation: Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Haramizu
authors.forename: Akira
authors.initials: A
authors.lastname: Shimotoyodome
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fukuoka
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Murase
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hase
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000493:pharmacokinetics; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D005080:Exercise Test; D006895:Hydroxyethyl Starch Derivatives / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D002365:Manihot / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction / Q000187:drug effects; D010805:Physical Conditioning, Animal / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology; D019518:Postprandial Period / Q000187:drug effects; D013213:Starch / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D006895:Hydroxyethyl Starch Derivatives; D010936:Plant Extracts; C050767:hydroxypropyl distarch phosphate; D013213:Starch