title: Simultaneous determination of non-steroidal anti-inflammatory drugs in river water by gas chromatography-mass spectrometry.
abstract: The gas chromatography/mass spectrometric assay method was developed for the determination of 13 non-steroidal anti-inflammatory drugs (NSAIDs) in river water. Extraction was achieved by a liquid-phase extraction procedure using methylene chloride. The extract was reacted for 30 min at 80°C based on the formation of methyl ester with 1.0 M HCl in methanol and extraction of the derivative with ethyl acetate, which was then measured by gas chromatography-mass spectrometry. The limit of quantification of NSAIDs was 1.0-60 ng/L and the calibration curve showed linearity being greater than r=0.997. The method was used to analyze ten river water samples from various regions in Korea. Diclofenac, indoprofen, ketoprofen and loxoprofen were detected at concentration of up to 1.29 μg/L in river water. The developed method may prove valuable for use in the national monitoring project of NSAIDs in surface water.
authors.affiliation: Department of Environmental Education, Kongju, Republic of Korea. hshin@kongju.ac.kr
authors.forename: Ho-Sang
authors.initials: HS
authors.lastname: Shin
authors.forename: Jin-Aa
authors.initials: JA
authors.lastname: Oh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D045483:Rivers / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014874:Water Pollutants, Chemical