title: Acute coronary syndromes in patients with chronic kidney disease.
abstract: Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosis present in CKD patients also leads to a decline in renal function. Definite data concerning the treatment of heart failure in CKD patients are lacking, because patients with significant renal impairment have mostly been excluded from randomized studies. Nevertheless, it seems that CKD patients should receive similar cardiovascular treatment to that used in patients with normal kidney function, but the doses of drugs ought to be titrated to achieve an optimal effect while avoiding adverse events. Several studies have also shown that despite the high risk, in patients with acute coronary syndrome (ACS), revascularization procedures in patients with CKD appear to be advantageous in the long run and are therefore justified. However, large clinical trials are needed to confirm the benefits and to identify possible disadvantages associated with various methods of treatment.
authors.affiliation: Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland. maciejbanach@aol.co.uk.
authors.forename: Beata
authors.initials: B
authors.lastname: Franczyk-Skóra
authors.forename: Anna
authors.initials: A
authors.lastname: Gluba
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.forename: Piotr
authors.initials: P
authors.lastname: Rozentryt
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*