title: Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction.
abstract: We report a patient showing isolated phonological agraphia after an ischemic stroke involving the left supramarginal gyrus (SMG). In this patient, we investigated the effects of focal repetitive transcranial magnetic stimulation (rTMS) given as theta burst stimulation (TBS) over the left SMG, corresponding to the Brodmann area (BA) 40. The patient and ten control subjects performed a dictational words and nonwords writing task before, and 5 and 30 min after they received excitatory intermittent TBS (iTBS) over the left BA 40, the right hemisphere homologous to BA 40, the Wernicke's area, or the primary visual cortex. ITBS over the left SMG lead to a brief facilitation of phonological non-words writing to dictation. This case study report illustrates that rTMS is able to influence, among other language functions, the phonological loading processes during the written language production in stroke patients.
authors.affiliation: Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria. raffaele.nardone@asbmeran-o.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Nardone
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: De Blasi
authors.forename: Giulio
authors.initials: G
authors.lastname: Zuccoli
authors.forename: Frediano
authors.initials: F
authors.lastname: Tezzon
authors.forename: Stefan
authors.initials: S
authors.lastname: Golaszewski
authors.forename: Eugen
authors.initials: E
authors.lastname: Trinka
mesh_terms: D000381:Agraphia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology / Q000502:physiology*; D010700:Phonetics; D013702:Temporal Lobe / Q000502:physiology; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D014793:Visual Cortex / Q000502:physiology