title: The role of signal transducer and activator of transcription-2 in the interferon response.
abstract: The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3. Numerous studies have confirmed that STAT2 operates as a positive regulator in the transcriptional activation response elicited by IFNs. In this article, we highlight the progress made in elucidating the pivotal role of STAT2 in driving the expression of IFN-induced genes, innate antiviral immunity, apoptosis, and cancer. A better understanding of the functional role of STAT2 in the IFN response and how STAT2 is regulated will uncover new clues to its role in diseases.
authors.affiliation: Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Håkan C
authors.initials: HC
authors.lastname: Steen
authors.forename: Ana M
authors.initials: AM
authors.lastname: Gamero
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000378:metabolism* / Q000494:pharmacology; D046912:Multiprotein Complexes; D017434:Protein Structure, Tertiary; D050794:STAT1 Transcription Factor / Q000378:metabolism; D050795:STAT2 Transcription Factor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic / Q000187:drug effects; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000187:drug effects / Q000276:immunology
chemical_list: D046912:Multiprotein Complexes; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; D007372:Interferons