title: Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis.
abstract: Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.
authors.affiliation: University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA. Francis.wilson@uphs.upenn.edu
authors.forename: F Perry
authors.initials: FP
authors.lastname: Wilson
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Bachhuber
authors.forename: Daniel
authors.initials: D
authors.lastname: Caroff
authors.forename: Rebecca
authors.initials: R
authors.lastname: Adler
authors.forename: Douglas
authors.initials: D
authors.lastname: Fish
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Berns
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood*; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D007683:Kidney Tubular Necrosis, Acute / Q000628:therapy; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012770:Shock, Cardiogenic / Q000628:therapy; D013056:Spectrophotometry, Ultraviolet; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime