title: Multifunctional plasmonic shell-magnetic core nanoparticles for targeted diagnostics, isolation, and photothermal destruction of tumor cells.
abstract: Cancer is the greatest challenge in human healthcare today. Cancer causes 7.6 million deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and effective treatment of cancer are crucial for saving lives. Driven by these needs, we report the development of a multifunctional plasmonic shell-magnetic core nanotechnology-driven approach for the targeted diagnosis, isolation, and photothermal destruction of cancer cells. Experimental data show that aptamer-conjugated plasmonic/magnetic nanoparticles can be used for targeted imaging and magnetic separation of a particular kind of cell from a mixture of different cancer cells. A targeted photothermal experiment using 670 nm light at 2.5 W/cm(2) for 10 min resulted selective irreparable cellular damage to most of the cancer cells. We also showed that the aptamer-conjugated magnetic/plasmonic nanoparticle-based photothermal destruction of cancer cells is highly selective. We discuss the possible mechanism and operating principle for the targeted imaging, separation, and photothermal destruction using magnetic/plasmonic nanotechnology.
authors.affiliation: Department of Chemistry, Jackson State University, Jackson, Mississippi 39217, United States.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fan
authors.forename: Melanie
authors.initials: M
authors.lastname: Shelton
authors.forename: Anant Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Dulal
authors.initials: D
authors.lastname: Senapati
authors.forename: Sadia Afrin
authors.initials: SA
authors.lastname: Khan
authors.forename: Paresh Chandra
authors.initials: PC
authors.lastname: Ray
mesh_terms: D045744:Cell Line, Tumor; D002469:Cell Separation / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D059346:Magnets / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011878:Radiotherapy / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide