title: [Correlations between PBDEs and thyroid hormone concentrations in adults from production source area].
abstract: Polybrominated diphenyl ethers (PBDEs) concentrations in 36 resident serum samples from PBDEs production source area were analyzed by gas chromatography/negative chemical ionization/mass spectrometry(GC-NCI-MS) method, and the concentrations of thyroid hormones were determined as well. The sigma5PBDEs (BDE-28, -47, -153, -183, -209) concentrations(lipid weight) in serum ranged from 130.3 to 4 478.4 ng x g(-1), with an average value of 529.9 ng x g(-1). BDE-209 was a dominant PBDE congener, on average accounting for 69.8% of the total PBDEs concentrations. Spearman rank correlation coefficient was calculated between PBDEs and thyroid hormone, it showed that there were high significant negative correlation between BDE-28, -47, -153, -183 and thyroid-stimulating hormone (TSH), and significant negative correlation was also found between BDE-183 and free thyroxine (fT4). Additionally, there were significant positive correlation between BDE-28, -47 and triiodothyronine (T3), as well as between BDE-28, -153, -183 and free triiodothyronine(fT3). In summary, the concentrations of PBDEs in serum in this study were at a high level, and BDE-209 was the predominant congener. The exposure to the PBDEs may affect thyroid hormone levels, and the further research should focus on the relationship between PBDEs and thyroid hormone concentrations.
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China. gallon.li@163.com
authors.forename: Ming-Yuan
authors.initials: MY
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.forename: Cong-Qiao
authors.initials: CQ
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Ding
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Yang
authors.forename: An-Ming
authors.initials: AM
authors.lastname: Liu
mesh_terms: D000328:Adult; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D013963:Thyroid Hormones; D014284:Triiodothyronine; C086401:pentabromodiphenyl ether; D013972:Thyrotropin; D013974:Thyroxine