title: Differential effect of lithium treatment on fenfluramine-induced decreases in food intake and locomotor activity in rats.
abstract: Administration of fenfluramine to rats decreased 1-h food intake and locomotor activity. Short-term (2-6 days) but not long-term (21-25 days) lithium treatment potentiated fenfluramine-induced suppression of food intake. However, neither short-term nor long-term lithium treatment had any significant effect on fenfluramine-induced suppression of locomotor activity. These findings demonstrate a differential effect of lithium treatment on fenfluramine-induced suppression of food intake and locomotor activity. Furthermore, these findings are consistent with results from several other animal and clinical studies demonstrating a differential effect of lithium treatment on two different serotonin-mediated functions.
authors.affiliation: Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health.
authors.forename: C S
authors.initials: CS
authors.lastname: Aulakh
authors.forename: J
authors.initials: J
authors.lastname: Zohar
authors.forename: K M
authors.initials: KM
authors.lastname: Wozniak
authors.forename: J L
authors.initials: JL
authors.lastname: Hill
authors.forename: D L
authors.initials: DL
authors.lastname: Murphy