title: Glucose tolerance in patients with narcolepsy.
abstract: OBJECTIVE
  Obesity is a common feature of narcolepsy. In addition, an increased occurrence of non-insulin dependent diabetes has been reported. So far, it is not known whether glucose metabolism in narcolepsy is disturbed due to, or independently of obesity.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Sleep medicine clinic at a research institute.
  
  
  METHODS
  We studied 17 patients with narcolepsy/cataplexy compared to 17 healthy controls matched for age, sex, and body mass index (BMI).
  
  
  METHODS
  A 75-g oral glucose tolerance test was performed.
  
  
  METHODS
  Glucose tolerance was determined by computing plasma glucose curve following oral glucose challenge for 240 minutes; insulin sensitivity and insulin secretion by homeostasis model assessment and minimal model analysis.
  
  
  RESULTS
  Standard outcome measures and indices of the oral glucose tolerance test did not differ between the patient group and the group of control subjects.
  
  
  CONCLUSIONS
  In this study, no clinically relevant pathologic findings in the glucose metabolism of narcoleptic patients compared to weight matched controls were found. Thus, narcolepsy is unlikely to be a risk factor per se for impaired glucose tolerance or diabetes.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Beitinger
authors.forename: Stephany
authors.initials: S
authors.lastname: Fulda
authors.forename: Mira A
authors.initials: MA
authors.lastname: Dalal
authors.forename: Renate
authors.initials: R
authors.lastname: Wehrle
authors.forename: Marietta
authors.initials: M
authors.lastname: Keckeis
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wetter
authors.forename: Fang
authors.initials: F
authors.lastname: Han
authors.forename: Thomas
authors.initials: T
authors.lastname: Pollmächer
authors.forename: Andreas
authors.initials: A
authors.lastname: Schuld
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose; D016022:Case-Control Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D005949:Glucose Oxidase / Q000097:blood; D005951:Glucose Tolerance Test / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007118:Immunoassay; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009290:Narcolepsy / Q000097:blood / Q000150:complications*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005949:Glucose Oxidase