title: Isolation and cytotoxic activity of selaginellin derivatives and biflavonoids from Selaginella tamariscina.
abstract: Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin ( 6), hinokiflavone (7), pulvinatabiflavone (8), and 7''- O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1- 9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines.
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China. Zhangguogang821@hotmail.com
authors.forename: Guo-gang
authors.initials: GG
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jing
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Zhang
authors.forename: En-long
authors.initials: EL
authors.lastname: Ma
authors.forename: Jin
authors.initials: J
authors.lastname: Guan
authors.forename: Feng-ning
authors.initials: FN
authors.lastname: Xue
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Liu
authors.forename: Xiao-ya
authors.initials: XY
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D044946:Biflavonoids / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000494:pharmacology; D003603:Cytotoxins / Q000494:pharmacology; D005910:Glioma / Q000188:drug therapy; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D001713:Biphenyl Compounds; D003512:Cyclohexanones; D003603:Cytotoxins; D010936:Plant Extracts; C548607:selaginellin C