title: Kinetics and tissue distribution of neutron-activated zinc oxide nanoparticles and zinc nitrate in mice: effects of size and particulate nature.
abstract: Although zinc oxide nanoparticles (ZnONPs) have been applied in nanotechnology, their kinetics and tissue distribution in vivo are unknown. Here we compared the kinetics and tissue distribution of 10 nm (65)ZnONPs, 71 nm (65)ZnONPs and (65)Zn(NO(3))(2) in mice after intravenous injection. The areas under the curves and the half-lives in the second compartment of (65)Zn(NO(3))(2) were greater than those of (65)ZnONPs; the kinetic parameters were similar for both (65)ZnONPs. However, the tissue distributions for the three forms were different. ZnONPs preferentially accumulated in the liver and spleen at 24 h. At day 28, (65)Zn concentration was highest in bone and the proportion of recovered (65)Zn radioactivity was highest in the carcass; these had the same ranking, 10 nm (65)ZnONPs > 71 nm (65)ZnONPs>  (65)Zn(NO(3))(2). Although more than 80% of the 10 nm (65)ZnONPs had been excreted by day 28, greater amounts of the 10 nm (65)ZnONPs than the 71 nm (65)ZnONPs or (65)Zn(NO(3))(2) had accumulated in other organs (brain, lung, heart and kidneys). Zn ions seem to have a longer half-life in the plasma, but ZnONPs show greater tissue accumulation. Although the size of the ZnONPs had no obvious effect on the kinetics, nevertheless the smaller ZnONPs tended to accumulate preferentially in some organs.
authors.affiliation: Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Teng-Kuang
authors.initials: TK
authors.lastname: Yeh
authors.forename: Jen-Kun
authors.initials: JK
authors.lastname: Chen
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Lin
authors.forename: Mo-Hsiung
authors.initials: MH
authors.lastname: Yang
authors.forename: Chung Shi
authors.initials: CS
authors.lastname: Yang
authors.forename: Fong-In
authors.initials: FI
authors.lastname: Chou
authors.forename: Jinn-Jer
authors.initials: JJ
authors.lastname: Peir
authors.forename: Mei-Ya
authors.initials: MY
authors.lastname: Wang
authors.forename: Wan-Hsuan
authors.initials: WH
authors.lastname: Chang
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Tsai
authors.forename: Hui-Ti
authors.initials: HT
authors.lastname: Tsai
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
mesh_terms: D000818:Animals; D007700:Kinetics; D008297:Male; D008422:Materials Testing; D008657:Metabolic Clearance Rate; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D009502:Neutrons; D009566:Nitrates / Q000737:chemistry / Q000493:pharmacokinetics* / Q000528:radiation effects; D010316:Particle Size; D014018:Tissue Distribution; D017967:Zinc Compounds / Q000737:chemistry / Q000493:pharmacokinetics* / Q000528:radiation effects; D015034:Zinc Oxide / Q000737:chemistry / Q000493:pharmacokinetics* / Q000528:radiation effects
chemical_list: D009566:Nitrates; D017967:Zinc Compounds; C042103:zinc nitrate; D015034:Zinc Oxide