title: Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population.
abstract: OBJECTIVE
  We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis.
  
  
  RESULTS
  APOEε4 was demonstrated to increase the risk of Alzheimer's disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer's disease and controls following a recessive model.
  
  
  CONCLUSIONS
  Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.
authors.affiliation: Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, China.
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Deng
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Pei-Jing
authors.initials: PJ
authors.lastname: Cui
authors.forename: Qing-Zhou
authors.initials: QZ
authors.lastname: Fei
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Ding
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000378:metabolism; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D051152:Clusterin / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D051152:Clusterin