title: Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives.
abstract: 5-Methoxyflavenes and 6-methoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate a range of novel chromeno[2,3-b]chromene derivatives. When subjected to an in vitro antiplasmodial growth inhibition assay using Plasmodium falciparum (3D7 line) the chromene analogues were shown to display IC(50) values ranging from 6.8 to 39.8 μM.
authors.affiliation: School of Chemistry, The University of New South Wales, UNSW, Sydney, NSW 2052, Australia.
authors.forename: Ruth
authors.initials: R
authors.lastname: Devakaram
authors.forename: David StC
authors.initials: DS
authors.lastname: Black
authors.forename: Vanida
authors.initials: V
authors.lastname: Choomuenwai
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D001578:Benzopyrans; D007529:Isoflavones