title: The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour.
abstract: OBJECTIVE
  Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combination of components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C>G) FOXL2 mutation and adult-type GCT, we analysed a series of gynandroblastomas for this mutation.
  
  
  RESULTS
  Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C>G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST/SLT component of six cases, three of which contained adult-type GCT.
  
  
  CONCLUSIONS
  This suggests that, despite their similar morphological appearances, the GCT-like component of gynandroblastoma has a different molecular basis from conventional adult-type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.
authors.affiliation: Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Oparka
authors.forename: Andrew
authors.initials: A
authors.lastname: Cassidy
authors.forename: Stephanie
authors.initials: S
authors.lastname: Reilly
authors.forename: Alasdair
authors.initials: A
authors.lastname: Stenhouse
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
authors.forename: C Simon
authors.initials: CS
authors.lastname: Herrington
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005350:Fibroma / Q000235:genetics / Q000473:pathology; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006106:Granulosa Cell Tumor / Q000235:genetics* / Q000473:pathology; D006801:Humans; D061346:Laser Capture Microdissection; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D017354:Point Mutation; D055815:Young Adult
chemical_list: C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors