title: Altered prefronto-striato-parietal network response to mental rotation in HIV.
abstract: The present study used functional magnetic resonance imaging to examine the neural substrates of mental rotation in 11 individuals with HIV infection and 13 demographically similar HIV seronegative volunteers. Individuals with HIV showed increased brain response to mental rotation in prefrontal and posterior parietal cortices, striatum, and thalamus, with significant HIV by angle interactions emerging in the prefrontal cortex and caudate. Results indicate that HIV infection is associated with altered brain response to mental rotation in fronto-striato-parietal pathways, which may reflect compensatory strategies, recruitment of additional brain regions, and/or increased neuroenergetic demands during mental rotation needed to offset underlying HIV-associated neural injury.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. brian.schweinsburg@yale.edu
authors.forename: Brian C
authors.initials: BC
authors.lastname: Schweinsburg
authors.forename: J Cobb
authors.initials: JC
authors.lastname: Scott
authors.forename: Alecia Dager
authors.initials: AD
authors.lastname: Schweinsburg
authors.forename: Joanna
authors.initials: J
authors.lastname: Jacobus
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Theilmann
authors.forename: Larry R
authors.initials: LR
authors.lastname: Frank
authors.forename: Erica
authors.initials: E
authors.lastname: Weber
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
mesh_terms: D000328:Adult; D003071:Cognition; D003342:Corpus Striatum / Q000503:physiopathology*; D005260:Female; D015658:HIV Infections / Q000503:physiopathology* / Q000523:psychology / Q000821:virology; D006801:Humans; D007092:Imagination; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012399:Rotation; D013028:Space Perception; D013788:Thalamus / Q000503:physiopathology