title: [Duodenojejunal bypass in treatment for 7 cases with non-severe obese type 2 diabetes mellitus].
abstract: OBJECTIVE
  To investigate the efficacy and feasibility of duodenojejunal bypass(DJB)on non-severe obese patients with type 2 diabetes mellitus(T2DM).
  
  
  METHODS
  The body mass index (BMI), fasting plasma glucose(FPG), 2h-postprandial plasma glucose(2hPG), fasting insulin(F-ins), fasting c-peptide(F-CP), glycated hemoglobin and hypoglycemic agents dose changes were tested in 7 patients with non-severe obese T2DM undergoing DJB, preoperatively and within 24 weeks after surgery during the follow-up. Data were collected and the clinical outcomes of T2DM were analyzed.
  
  
  RESULTS
  In 7 cases of non-obese T2DM who underwent DJB, one patient was weaned off hypoglycemic agents with normal FPG, 2hPG and HbA1c postoperatively. Five required significantly lower dosage. No significant improvement in 1 case. Complete remission rate of hyperglycemia was 1/7, effective rate was 6/7, and effective rate of HbA1c was 5/7. No significant changes in BMI were observed between the preoperative and postoperative phases.
  
  
  CONCLUSIONS
  Plasma glucose level can be markedly reduced by duodenojejunal bypass in non-obese T2DM, independent of weight loss, and the mechanism remains unclear.
authors.affiliation: Department of Laparoscopic Surgery, Wenzhou Medical College, Zhejiang, Wenzhou, China.
authors.forename: Fei-zhao
authors.initials: FZ
authors.lastname: Jiang
authors.forename: Heng-liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zheng
authors.forename: Jin-fu
authors.initials: JF
authors.lastname: Tu
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.forename: Ru-ying
authors.initials: RY
authors.lastname: Hu
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.forename: He-yi
authors.initials: HY
authors.lastname: You
authors.forename: Zhen-xu
authors.initials: ZX
authors.lastname: Zhou
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D050110:Bariatric Surgery / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016896:Treatment Outcome