title: Evidence that the main adverse effect of ganirelix on pregnancy and implantation rates is on the embryo rather than the endometrium.
abstract: OBJECTIVE
  To compare pregnancy rates following the transfer of thawed frozen embryos according to the type of GnRH antagonist or agonist used during controlled ovarian hyperstimulation (COH).
  
  
  METHODS
  Retrospective review of frozen embryo transfers according to whether a GnRH agonist or antagonist was used. Furthermore to determine if a specific antagonist/agonist resulted in higher pregnancy rates than the other.
  
  
  RESULTS
  The pregnancy rates in two different age categories were similar whether the COH regimen used the GnRH agonist leuprolide acetate or the GnRH antagonist cetrorelix. However, lower pregnancy rates were found with the GnRH antagonist ganirelix.
  
  
  CONCLUSIONS
  These data reached similar conclusions as was found comparing these three agents in fresh embryo transfer.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.forename: J
authors.initials: J
authors.lastname: Amui
authors.forename: J K
authors.initials: JK
authors.lastname: Choe
authors.forename: D
authors.initials: D
authors.lastname: Brasile
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004717:Endometrium / Q000187:drug effects; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000819:agonists / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide; C061018:ganirelix; C062876:cetrorelix