title: Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
abstract: It is unknown what role uric acid (UA) may play in the increasing rates of cardiovascular disease (CVD) among Alaska Eskimos. UA is associated with both hypertension (HTN) and chronic kidney disease (CKD). The authors analyzed 1078 Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) participants. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine measures using the Modification of Diet in Renal Disease equation. CKD was defined by an eGFR of <60 mL/min/1.73 m(2) . The authors adjusted for age, sex, education, diabetes, hypertension (or eGFR), obesity, lipids, and smoking status; 7% (n=75) had prevalent CKD. eGFR decreased with increasing tertiles of serum UA (P<.001). UA was independently associated with prevalent CKD (adjusted odds ratio [OR] and 95% confidence interval [CI] of 2.04 (1.62-2.56), respectively). Twenty-one percent (n=230) had prevalent HTN and UA was independently associated with prevalent HTN (adjusted OR, 1.2; 95% CI, 1.1-1.5). UA is independently associated with prevalent CKD and HTN in this population.
authors.affiliation: From General Internal Medicine, Cleveland Clinic Medicine Institute, Cleveland, OH.
authors.forename: Stacey E
authors.initials: SE
authors.lastname: Jolly
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD.
authors.forename: Mihriye
authors.initials: M
authors.lastname: Mete
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Norton Sound Health Corporation, Nome, AK.
authors.forename: Sven O E
authors.initials: SOE
authors.lastname: Ebbesson
authors.affiliation: Texas Biomedical Research Institute, San Antonio, TX.
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.affiliation: Texas Biomedical Research Institute, San Antonio, TX.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD.|Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC.
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD.|Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Umans
mesh_terms: D000328:Adult; D000413:Alaska / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology*; D004930:Inuit; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000208:ethnology*; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid