title: Semi-automated mitral valve morphometry and computational stress analysis using 3D ultrasound.
abstract: In vivo human mitral valves (MV) were imaged using real-time 3D transesophageal echocardiography (rt-3DTEE), and volumetric images of the MV at mid-systole were analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation, a compact representation of shape. The resulting MV models were loaded with physiologic pressures using finite element analysis (FEA). We present the regional leaflet stress distributions predicted in normal and diseased (regurgitant) MVs. Rt-3DTEE, semi-automated leaflet segmentation, 3D deformable modeling, and FEA modeling of the in vivo human MV is tenable and useful for evaluation of MV pathology.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Pouch
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Yushkevich
authors.forename: Arminder S
authors.initials: AS
authors.lastname: Jassar
authors.forename: Mathieu
authors.initials: M
authors.lastname: Vergnat
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Gorman
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gorman
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Sehgal
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Jackson
mesh_terms: D019560:Echocardiography, Three-Dimensional / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D020342:Finite Element Analysis; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000473:pathology*; D008955:Models, Cardiovascular; D014465:Ultrasonics / Q000379:methods