title: [Pathological anatomical characteristics of Klatskin tumors. Classification, current molecular biological aspects, prognosis factors].
abstract: Klatskin tumors are a distinct subgroup of cholangiocarcinomas which are a surgical challenge due to their special localization. Different localizations do not show great differences concerning histomorphology and precursor lesions. With respect to molecular alterations there are only small differences. Accurate clinical and histomorphological diagnosis is important for therapy and especially the prediction of prognosis as well as standardized processing of the resection specimen if the carcinoma is resectable. Additionally, accurate lymph node dissection is necessary. Concerning molecular markers further investigations are needed to develop individualized therapy regimes.
authors.affiliation: Institut für Pathologie, BG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum. Johanna.Munding@rub.de
authors.forename: J
authors.initials: J
authors.lastname: Munding
authors.forename: A
authors.initials: A
authors.lastname: Tannapfel
mesh_terms: D001650:Bile Duct Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000235:genetics; D002278:Carcinoma in Situ / Q000145:classification / Q000235:genetics / Q000473:pathology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004249:DNA Damage; D004252:DNA Mutational Analysis; D006500:Hepatic Duct, Common / Q000473:pathology*; D006801:Humans; D018285:Klatskin Tumor / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor