title: The abundance of deleterious polymorphisms in humans.
abstract: Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
authors.affiliation: Australian Rivers Institute, Griffith School of Environment, Griffith University, Nathan, Queensland 4111, Australia. s.subramanian@griffith.edu.au
authors.forename: Sankar
authors.initials: S
authors.lastname: Subramanian
mesh_terms: D000220:Adaptation, Biological; D019943:Amino Acid Substitution; D005006:Ethnicity / Q000235:genetics; D019143:Evolution, Molecular; D005787:Gene Frequency; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D013997:Time Factors