title: Development of bacterially resistant polyurethane for coating medical devices.
abstract: Polyurethanes have been widely used in medicine for coating and packaging implantable and other medical devices. Polyether-urethanes, in particular, have superior mechanical properties and are biocompatible, but in common with other medical materials they are susceptible to microbial film formation. In this study, polyether-urethane was end-capped with silver lactate and silver sulfadiazine functional groups to produce a bacterially resistant polymer without sacrificing the useful mechanical properties of the polyether-polyurethane. The silver ions were covalently incorporated into the polymer during chain extension of the prepolymer. The functionalized polymers were structurally characterized by light scattering, electron microscopy, NMR, FTIR and Raman spectroscopy. Mechanical properties, hydrophilicity, in vitro stability and antibacterial action of polymers were also investigated. Results indicate that both silver salts were successfully incorporated into the polymer structure without significant effect on mechanical properties, whilst conferring acceptable bacterial resistance.
authors.affiliation: School of Engineering and Materials Science, IRC in Biomedical Materials, Queen Mary University, London, UK. n.roohpour@qmul.ac.uk
authors.forename: Nima
authors.initials: N
authors.lastname: Roohpour
authors.forename: Alireza
authors.initials: A
authors.lastname: Moshaverinia
authors.forename: Jaroslaw M
authors.initials: JM
authors.lastname: Wasikiewicz
authors.forename: Deepen
authors.initials: D
authors.lastname: Paul
authors.forename: Mark
authors.initials: M
authors.lastname: Wilks
authors.forename: Michael
authors.initials: M
authors.lastname: Millar
authors.forename: Pankaj
authors.initials: P
authors.lastname: Vadgama
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004866:Equipment Contamination / Q000517:prevention & control*; D004864:Equipment and Supplies / Q000382:microbiology*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects*; D008422:Materials Testing; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D011140:Polyurethanes