title: Transcriptional enhancers in development and disease.
abstract: Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. nsakabe@uchicago.edu
authors.forename: Noboru Jo
authors.initials: NJ
authors.lastname: Sakabe
authors.forename: Daniel
authors.initials: D
authors.lastname: Savic
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Nobrega
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D016678:Genome; D055106:Genome-Wide Association Study; D006801:Humans; D014158:Transcription, Genetic