title: No association between infections, HLA type and other transplant-related factors and risk of cutaneous squamous cell carcinoma in solid organ transplant recipients.
abstract: Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden. asa.ingvar@karolinska.se
authors.forename: Åsa
authors.initials: Å
authors.lastname: Ingvar
authors.forename: Karin
authors.initials: K
authors.lastname: Ekström Smedby
authors.forename: Bernt
authors.initials: B
authors.lastname: Lindelöf
authors.forename: Pia
authors.initials: P
authors.lastname: Fernberg
authors.forename: Rino
authors.initials: R
authors.lastname: Bellocco
authors.forename: Gunnar
authors.initials: G
authors.lastname: Tufveson
authors.forename: Petter
authors.initials: P
authors.lastname: Höglund
authors.forename: Johanna
authors.initials: J
authors.lastname: Adami
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000209:etiology* / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D016377:Organ Transplantation / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology; D013548:Sweden; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D007166:Immunosuppressive Agents