title: [Methabolism of connective tissue in patients with complicated chronic pancreatitis].
abstract: A content in the blood serum of a free and connected oxyproline, collagenolytic activity of the blood, the level of glycosaminoglycans and elastase activity was detected in chronic pancreatitis (CHP). There were examined 73 patients (64 men and 9 women). CHP in a stage B (according to M. Buchler et al., 2009) was established in 26 (35.6%) patients, C1 - in 18 (24.6%), C2 - in 17 (23.4%), C3 - in 12 (16.4%). A progress of pancreatic fibrosis in CHP have occurred on a background of a high activity of elastase in neutrophils, a glycosaminoglycans level raising, as well as a free and connected oxyproline. A detection of a neutrophils elastase activity and oxyproline content in the blood serum may be used in a clinical practice as additional diagnostic criteria of estimation of the pancreatic pathology severity. The changes revealed were the same as in CHP of alcoholic and of the other nature.
authors.forename: I A
authors.initials: IA
authors.lastname: Krivoruchko
authors.forename: V V
authors.initials: VV
authors.lastname: Boĭko
authors.forename: V I
authors.initials: VI
authors.lastname: Zhukov
authors.forename: N N
authors.initials: NN
authors.lastname: Goncharova
authors.forename: S A
authors.initials: SA
authors.lastname: Andreeshchev
authors.forename: A S
authors.initials: AS
authors.lastname: Moiseenko
mesh_terms: D000328:Adult; D003094:Collagen / Q000097:blood; D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D005355:Fibrosis; D006025:Glycosaminoglycans / Q000097:blood; D006801:Humans; D006909:Hydroxyproline / Q000097:blood; D008297:Male; D010179:Pancreas / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010196:Pancreatic Elastase / Q000097:blood; D050500:Pancreatitis, Chronic / Q000097:blood / Q000150:complications* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012720:Severity of Illness Index
chemical_list: D006025:Glycosaminoglycans; D003094:Collagen; D010196:Pancreatic Elastase; D006909:Hydroxyproline