title: Early screening for preeclampsia.
abstract: Preeclampsia, which affects about 3 to 5% of pregnant women, is the most frequent medical complication in pregnancy and the most important cause of maternal and perinatal morbidity and mortality. During the past three decades, numerous clinical, biophysical, and biochemical screening tests have been proposed for the early detection of preeclampsia. Literature shows large discrepancies in the sensitivity and predictive value of several of these tests. No single screening test used for preeclampsia prediction has gained widespread acceptance into clinical practice. Instead, its value seems to be in increasing the predictive value of panels of tests, which include other clinical measurements. The aim of this review was to examine the combination of maternal risk factors, mean arterial blood pressure, and uterine artery Doppler, together with biomarkers in the preeclampsia prediction.
authors.affiliation: Department of Perinatal Medicine and Pauline Gandel Imaging Centre, Royal Women’s Hospital, Parkville – Victoria, Australia.
authors.forename: Fabrício da Silva
authors.initials: Fda S
authors.lastname: Costa
authors.forename: Padma
authors.initials: P
authors.lastname: Murthi
authors.forename: Rosemary
authors.initials: R
authors.lastname: Keogh
authors.forename: Nicole
authors.initials: N
authors.lastname: Woodrow
mesh_terms: D015415:Biomarkers / Q000032:analysis; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers