title: ANCA-associated Goodpasture's syndrome in a patient with rheumatoid arthritis on penicillamine.
abstract: Although penicillamine has been used effectively in the management of a variety of diseases, several adverse reactions have been observed with prolonged administration of this agent. We report a case of Goodpasture's syndrome, as a result of induction of anti-myeloperoxidase antineutrophil cytoplasmic antibodies in a 51 year old man who was being treated with this drug for rheumatoid arthritis. This pulmonary-renal syndrome has been described on rare occasions in patients receiving penicillamine. Treatment with steroids and cyclophosphamide resulted in pulmonary and renal functional recovery.
authors.affiliation: Division of Nephrology and Renal Transplant Medicine, Medanta Kidney and Urology Institute, Medanta - The Medicity, Gurgaon, Haryana, India.
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: V
authors.initials: V
authors.lastname: Kher