title: [Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease].
abstract: OBJECTIVE
  To study the value of anti-neutrophil cytoplasmic antibody (ANCA) in diagnosis of Kawasaki disease (KD).
  
  
  METHODS
  Serum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase.
  
  
  RESULTS
  The mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P<0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33% vs 65%, P<0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P<0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43% vs 13%; P<0.05).
  
  
  CONCLUSIONS
  Serum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.
authors.affiliation: Department of Pediatrics, Shunde Longjiang Hospital of Foshan, Foshan, Guangdong 528318, China. jzhg@163.com
authors.forename: Zhi-Gui
authors.initials: ZG
authors.lastname: Jiang
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Cui-Yan
authors.initials: CY
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000175:diagnosis*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic