title: NDM-1 has arrived: first report of a carbapenem resistance mechanism in South Africa.
abstract: The New Delhi Metallo-β-lactamase (NDM) resistance mechanism in Enterobacteriaceae threatens to render serious Gram-negative infections untreatable. The NDM-1 enzyme hydrolyses all available penicillin, cephalosporin and carbapenem antibiotics, and is commonly accompanied by additional resistance mechanisms to multiple antibiotic classes. Initially identified as a significant healthcare risk on the Indian sub-continent, it has rapidly become a global problem, posing significant diagnostic and management challenges. Here we report the first laboratory-confirmed case of NDM-1 in South Africa.
authors.forename: W
authors.initials: W
authors.lastname: Lowman
authors.forename: C
authors.initials: C
authors.lastname: Sriruttan
authors.forename: T
authors.initials: T
authors.lastname: Nana
authors.forename: N
authors.initials: N
authors.lastname: Bosman
authors.forename: A
authors.initials: A
authors.lastname: Duse
authors.forename: J
authors.initials: J
authors.lastname: Venturas
authors.forename: C
authors.initials: C
authors.lastname: Clay
authors.forename: J
authors.initials: J
authors.lastname: Coetzee
mesh_terms: D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000502:physiology; D016972:Enterobacter cloacae / Q000187:drug effects; D004755:Enterobacteriaceae / Q000201:enzymology; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013019:South Africa; D013183:Sputum / Q000382:microbiology*; D001618:beta-Lactamases / Q000302:isolation & purification*
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1