title: Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models.
abstract: In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40(o)C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.
authors.affiliation: 1. Bioimaging Research Center, University of Georgia, Athens, GA. 30602, USA;
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.forename: Luning
authors.initials: L
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Cheng
authors.forename: Leidong
authors.initials: L
authors.lastname: Mao
authors.forename: Robert D
authors.initials: RD
authors.lastname: Arnold
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Howerth
authors.forename: Zhuo G
authors.initials: ZG
authors.lastname: Chen
authors.forename: Simon
authors.initials: S
authors.lastname: Platt