title: Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery.
abstract: This study assessed the intraoperative analgesic effects of intravenous lidocaine administered by a constant rate infusion (CRI) in surgical canine patients. A prospective, blinded, randomized study was designed with 2 treatment groups: A (lidocaine) and B (placebo), involving 41 dogs. All patients were premedicated with acepromazine and buprenorphine, induced with propofol and midazolam; anesthesia was maintained with isoflurane in oxygen. Group A received 2 mg/kg IV lidocaine immediately after induction, followed within 5 min by a CRI at 50 μg/kg/min. Group B received an equivalent volume of saline instead of lidocaine. Changes in heart rate and blood pressure during maintenance were treated by increasing CRI. Fentanyl was used as a supplemental analgesic when intraoperative nociceptive response was not controlled with the maximum dose of lidocaine infusion. There was a significantly lower use of supplemental intraoperative analgesia in the lidocaine than in the placebo group. Group B dogs had almost twice as high a risk of intraoperative nociceptive response as group A dogs.
authors.affiliation: Service of Anesthesia, Veterinary Teaching Hospital, University of Zaragoza, Zaragoza, Spain. maria.ortega.prieto@gmail.com
authors.forename: Maria
authors.initials: M
authors.lastname: Ortega
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cruz
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004283:Dog Diseases / Q000601:surgery; D004285:Dogs / Q000502:physiology* / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007262:Infusions, Intravenous / Q000662:veterinary; D007430:Intraoperative Care / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D059408:Pain Management / Q000379:methods / Q000662:veterinary; D011897:Random Allocation
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D008012:Lidocaine; D007530:Isoflurane