title: [Lipid peroxidation and biomechanical properties of artery in hyperlipemia rats after treating with tetrahydrobiopterin].
abstract: OBJECTIVE
  To explore the effect of the level of lipid peroxidation and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in thoracic aorta of hyperlipemia (HL) rats.
  
  
  METHODS
  HL rats were given BH4 chronically. The opening angle in the zero-stress state and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image 8, 16, and 24 week-old respectively.
  
  
  RESULTS
  Treating with BH4 chronically from 8 week-old in HL rats, there was a significant increase in the zero-stress state of opening angle of thoracic aorta. The P-D curve of mesenteric artery moved upward.
  
  
  CONCLUSIONS
  Treating with BH4 prevented the structure and function of artery from abnormal changing, and attenuated lipid peroxidation in HL rats.
authors.affiliation: Department of Physiology, Jining Medical College, China. baoliangzhu@163.com
authors.forename: Bao-Liang
authors.initials: BL
authors.lastname: Zhu
authors.forename: Rui-Zhen
authors.initials: RZ
authors.lastname: Yan
authors.forename: Jiang
authors.initials: J
authors.lastname: Yu
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Dong
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism / Q000503:physiopathology*; D001696:Biomechanical Phenomena / Q000187:drug effects; D001708:Biopterins / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001708:Biopterins; C003402:sapropterin