title: [Severe thrombocytopenia on admission to the intensive care unit in patients with multiple organ failure].
abstract: OBJECTIVE
  To evaluate the frequency of severe thrombocytopenia (STCP) (≤ 50,000/μl) in the first 24 hours in patients with multiple organ dysfunction syndrome, and the factors that influence its occurrence.
  
  
  METHODS
  A retrospective, observational study. AREA: Medical-surgical intensive care unit (ICU). Tertiary hospital.
  
  
  METHODS
  Those with failure of at least two organs, according to SOFA criteria, with the exclusion of neurological and traumatologic critical cases.
  
  
  METHODS
  Medical history, regular medication, baseline functional status, demographic variables, severity scores in ICU, multiple-organ failure data, course in ICU and main hospital data.
  
  
  RESULTS
  A total of 587 patients were included; 6.3% (37 patients) presented with STCP during the first day of admission; 64.6% were men; SOFA 8 (5-10); APACHE II 18 (13-24); APACHE IV 59 (46-73); 32.5% were surgical patients. A total of 79.9% subsequently needed mechanical ventilation, and 71.4% required vasoactive drugs. Overall stay in ICU: 4 (2-10) days, main hospital stay 18 (9-35) days. A total of 29.2% died in the ICU; 11.7% developed STCP during admission to the ICU. Multivariate analysis found the main determining factors in the occurrence of thrombocytopenia on admission to be: history of hospitalization in the last year, albumin and bilirubin levels, and sepsis.
  
  
  CONCLUSIONS
  The prevalence of STCP among critical patients was 6.3%. Its occurrence was associated with albumin and bilirubin levels, sepsis, and with patient admittance in the last year.
authors.affiliation: Servicio de Medicina Intensiva, Complejo Hospitalario de Toledo, Toledo, España. marcel55@terra.es
authors.forename: C M
authors.initials: CM
authors.lastname: Marco-Schulke
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Casado
authors.forename: V A
authors.initials: VA
authors.lastname: Hortigüela-Martín
authors.forename: M
authors.initials: M
authors.lastname: Quintana-Díaz
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez-Villar
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez-Pedrero
authors.forename: A
authors.initials: A
authors.lastname: Velasco-Ramos
authors.forename: A
authors.initials: A
authors.lastname: Canabal-Berlanga
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Arrese-Cosculluela
mesh_terms: D018806:APACHE; D000368:Aged; D001663:Bilirubin / Q000097:blood; D003953:Diagnosis-Related Groups; D004363:Drug Utilization; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D010359:Patient Readmission / Q000706:statistics & numerical data; D010976:Platelet Count; D011183:Postoperative Complications / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D013921:Thrombocytopenia / Q000453:epidemiology* / Q000209:etiology
chemical_list: D001663:Bilirubin