title: Molecular serum and urine marker repertoire supporting clinical research on joint diseases.
abstract: The need for improved analytical techniques in the study of slow, degenerative diseases such as rheumatoid arthritis and osteoarthritis has driven major efforts aimed at identifying biochemical markers of pathological processes in both diseases. A series of novel biochemical markers has surfaced and their careful validation has become a critical requirement for further use in clinical research. This report aims at providing a critical review of biochemical markers applied in clinical research of joint diseases, in particular those markers reflecting the turnover of cartilage tissue.
authors.affiliation: Nordic Bioscience A/S, Herlev, Denmark. pq@nordicbioscience.com
authors.forename: Per
authors.initials: P
authors.lastname: Qvist
authors.forename: Anne-Christine
authors.initials: AC
authors.lastname: Bay-Jensen
authors.forename: Claus
authors.initials: C
authors.lastname: Christiansen
authors.forename: Bodil Cecilie
authors.initials: BC
authors.lastname: Sondergaard
authors.forename: Morten A
authors.initials: MA
authors.lastname: Karsdal
mesh_terms: D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D035843:Biomedical Research; D002358:Cartilage, Articular / Q000378:metabolism; D006801:Humans; D007592:Joint Diseases / Q000097:blood* / Q000503:physiopathology / Q000652:urine*
chemical_list: D015415:Biomarkers