title: Backbone and side chain 1H, 15N & 13C chemical shift assignments of the holo-acyl carrier protein (ACP) of Leishmania major.
abstract: Acyl carrier protein (ACP) is a small acidic protein, an important cofactor involved in fatty acid biosynthesis. Its main function is to protect the growing acyl chain from the hydrophilic environment during fatty acid biosynthesis and simultaneously, present it to the active site of fatty acid pathway enzymes, liable for its elongation. The ACP molecule is expressed as apo-ACP (inactive) and is post-transitionally modified to the holo form (active) by the enzyme holo ACP synthase (ACPS). Here we report the complete backbone and side chain chemical shift assignments of the holo-ACP molecule of Leishmania major.
authors.affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
authors.forename: Ambrish
authors.initials: A
authors.lastname: Kumar
authors.forename: Avadhesha
authors.initials: A
authors.lastname: Surolia
authors.forename: Monica
authors.initials: M
authors.lastname: Sundd
mesh_terms: D000213:Acyl Carrier Protein / Q000737:chemistry*; D000595:Amino Acid Sequence; D002247:Carbon Isotopes; D006863:Hydrogen-Ion Concentration; D018320:Leishmania major / Q000378:metabolism*; D008969:Molecular Sequence Data; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D011522:Protons; D015800:Protozoan Proteins / Q000737:chemistry*
chemical_list: D000213:Acyl Carrier Protein; D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011522:Protons; D015800:Protozoan Proteins