title: In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: a new class of antifilarial agents.
abstract: A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improved in vitro anti-filarial activity and examples 4d and 4f were also found to be active in the in vivo experiments. These results demonstrate that 3,6-epoxy [1,5]dioxocines exhibits potent antifilarial activity and might be developed into a new class of antifilarial drug.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Abdhesh
authors.initials: A
authors.lastname: Kumar
authors.forename: K Bhaskara
authors.initials: KB
authors.lastname: Rao
authors.forename: Vikas
authors.initials: V
authors.lastname: Kushwaha
authors.forename: Kirti
authors.initials: K
authors.lastname: Saxena
authors.forename: P K
authors.initials: PK
authors.lastname: Murthy
mesh_terms: D000818:Animals; D017178:Brugia malayi / Q000187:drug effects*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005369:Filaricides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D035964:Oxocins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004852:Epoxy Compounds; D005369:Filaricides; D035964:Oxocins