title: The Ph1 locus suppresses Cdk2-type activity during premeiosis and meiosis in wheat.
abstract: Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.
authors.affiliation: John Ines Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Greer
authors.forename: Azahara C
authors.initials: AC
authors.lastname: Martín
authors.forename: Ali
authors.initials: A
authors.lastname: Pendle
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colas
authors.forename: Alexandra M E
authors.initials: AM
authors.lastname: Jones
authors.forename: Graham
authors.initials: G
authors.lastname: Moore
authors.forename: Peter
authors.initials: P
authors.lastname: Shaw
mesh_terms: D051357:Cyclin-Dependent Kinase 2 / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D008540:Meiosis / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D014908:Triticum / Q000235:genetics / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D051357:Cyclin-Dependent Kinase 2