title: Transcription regulation system mediated by mechanical operation of a DNA nanostructure.
abstract: A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.
authors.affiliation: Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan. endo@kuchem.kyoto-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endo
authors.forename: Ryoji
authors.initials: R
authors.lastname: Miyazaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Emura
authors.forename: Kumi
authors.initials: K
authors.lastname: Hidaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D001483:Base Sequence; D001710:Biotin / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry; D004220:Disulfides; D005786:Gene Expression Regulation; D021621:Imaging, Three-Dimensional; D008969:Molecular Sequence Data; D053761:Nanocomposites; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D013314:Stress, Mechanical; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000737:chemistry
chemical_list: D004220:Disulfides; D014764:Viral Proteins; D001710:Biotin; D004247:DNA; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases