title: Serum γ-glutamyltransferase levels correlate with epicardial adipose tissue thickness in patients with coronary artery disease.
abstract: Epicardial adipose tissue (EAT) is related to the presence of coronary artery disease (CAD). Increased γ-glutamyltransferase (GGT) activity is associated with atherosclerosis. We assessed the relationship between EAT and serum GGT activity in addition to cardiovascular risk factors in patients with stable anginal symptoms. Consecutive patients (n = 120) who underwent coronary angiography were included. Epicardial adipose tissue thickness was measured by echocardiography. Serum GGT activity was measured by enzymatic colorimetric assay. Epicardial adipose tissue thickness and serum GGT activity were higher in patients with CAD (n = 83). Patients with metabolic syndrome (n = 83) were found to have higher EAT thickness. Serum GGT activity was independently associated with EAT values. In conclusion, echocardiographic EAT was significantly higher in patients with CAD and serum GGT activity correlated with EAT thickness.
authors.affiliation: Kavaklidere Umut Hospital, Cardiology Clinic, Ankara, Turkey. drmeltemege@yahoo.com.tr
authors.forename: Meltem Refiker
authors.initials: MR
authors.lastname: Ege
authors.forename: Umit
authors.initials: U
authors.lastname: Guray
authors.forename: Yesim
authors.initials: Y
authors.lastname: Guray
authors.forename: Burcu
authors.initials: B
authors.lastname: Demirkan
authors.forename: Halil
authors.initials: H
authors.lastname: Kisacik
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D060050:Angina, Stable / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D010496:Pericardium / Q000000981:diagnostic imaging*; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase