title: T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival.
abstract: Glycosylation affects many essential T cell processes and is intrinsically controlled throughout the lifetime of a T cell. CD43 and CD45 are the two most abundant glycoproteins on the T cell surface and are decorated with O- and N-glycans. Global T cell glycosylation and specific glycosylation of CD43 and CD45 are modulated during thymocyte development and T cell activation; T cells control the type and abundance of glycans decorating CD43 and CD45 by regulating expression of glycosyltransferases and glycosidases. Additionally, T cells regulate glycosylation of CD45 by expressing alternatively spliced isoforms of CD45 that have different glycan attachment sites. The glycophenotype of CD43 and CD45 on T cells influences how T cells interact with the extracellular environment, including how T cells interact with endogenous lectins. This review focuses on changes in glycosylation of CD43 and CD45 occurring throughout T cell development and activation and the role that glycosylation plays in regulating T cell processes, such as migration, T cell receptor signaling, and apoptosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, UCLA School of Medicine, University of California, Los Angeles, USA.
authors.forename: Mary C
authors.initials: MC
authors.lastname: Clark
authors.forename: Linda G
authors.initials: LG
authors.lastname: Baum
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D002465:Cell Movement; D002470:Cell Survival; D006031:Glycosylation; D006801:Humans; D017493:Leukocyte Common Antigens / Q000737:chemistry / Q000276:immunology*; D051917:Leukosialin / Q000737:chemistry / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D011134:Polysaccharides / Q000737:chemistry / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology
chemical_list: D051917:Leukosialin; D011134:Polysaccharides; D017493:Leukocyte Common Antigens