title: The biomimetic apatite-cefalotin coatings on modified titanium.
abstract: Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic efficacy could be enhanced with modified titanium. First, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on Streptococcus mutans. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modified titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modified titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.
authors.affiliation: BK21, Department and Research Institute of Dental Biomaterials and Bioengineering, and Research Center for Orofacial Hard Tissue Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Kang
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Lee
authors.forename: Seung-Kyun
authors.initials: SK
authors.lastname: Moon
authors.forename: Kwang-Mahn
authors.initials: KM
authors.lastname: Kim
authors.forename: Kyoung-Nam
authors.initials: KN
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001031:Apatites / Q000737:chemistry; D058491:Bacterial Load / Q000187:drug effects; D040761:Biomimetic Materials / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D017554:Carbon Compounds, Inorganic / Q000737:chemistry; D002512:Cephalothin / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D045662:Dental Etching / Q000379:methods; D003764:Dental Materials / Q000737:chemistry*; D004058:Diffusion; D017886:Durapatite / Q000737:chemistry*; D055664:Electrochemical Techniques; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D017655:Silicon Compounds / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D013295:Streptococcus mutans / Q000187:drug effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001031:Apatites; D002130:Calcium Phosphates; D017554:Carbon Compounds, Inorganic; D020099:Coated Materials, Biocompatible; D003764:Dental Materials; D017655:Silicon Compounds; C009495:titanium dioxide; C030782:carboapatite; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium; D002512:Cephalothin; C022088:silicon carbide