title: Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.
abstract: In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.
authors.affiliation: Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey. miyasegunduz@yahoo.com
authors.forename: M G
authors.initials: MG
authors.lastname: Gündüz
authors.forename: C
authors.initials: C
authors.lastname: Safak
authors.forename: B
authors.initials: B
authors.lastname: Kaygısız
authors.forename: B C
authors.initials: BC
authors.lastname: Koşar
authors.forename: R
authors.initials: R
authors.lastname: Simşek
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: A
authors.initials: A
authors.lastname: Linden
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects*; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009529:Nicardipine / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D053719:Tandem Mass Spectrometry; D058924:Thienopyridines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D003517:Cyclopentanes; D007202:Indicators and Reagents; D011725:Pyridines; D058924:Thienopyridines; D009529:Nicardipine