title: The impact of lower induction values of 50 Hz external electromagnetic fields on in vitro T lymphocyte adherence capabilities.
abstract: Our research thus far has concerned the impact of external electromagnetic fields (50 Hz) and low (0.01-10 mT) induction on adherence capabilities of T lymphocytes obtained from the blood of patients with head and neck tumors. We know that the in vitro adherence capability of T lymphocytes towards surfaces in cancer patients is less than that of control. Previously, we have found that exposure to electromagnetic fields (50 Hz/0.01-10 mT) increases the capability of T lymphocytes, in larynx/pharynx cancer patients, to adhere in vitro to surfaces, achieving almost physiological values, in not only pre-treatment patients but also those receiving treatment in the course of follow-up. The capability of T lymphocytes in controls (voluntary blood donors) to adhere to surfaces was also increased (50 Hz/0.01-0.5 mT). The present study concentrates on the significance of the level of electromagnetic field induction in order to determine whether low induction values can restore T lymphocytes adherence capabilities. Testing a subset of 20 patients showed a statistically significant difference (p<0.05) in the in vitro adherence capacity of T lymphocytes between both 0.01 and 0.05, and 0.1 mT induction levels. In the control group (patients diagnosed with chronic sensorineural hearing loss) there was even a statistically significant difference between induction values of 0.05 and 0.01 mT. A statistically significant difference (p<0.05) was also achieved with induction levels of 1 and 10 mT compared to 0.5, 0.1, and 0.05 mT, respectively. Therefore, we concluded that lower induction values resulted in a more biologically significant response.
authors.affiliation: 3rd Faculty of Medicine, Charles University in Prague, Department of Otorhinolaryngology, Faculty Hospital Královské Vinohrady, Prague, Czech Republic. ales.cocek@seznam.cz
authors.forename: Aleš
authors.initials: A
authors.lastname: Coček
authors.forename: Aleš
authors.initials: A
authors.lastname: Hahn
authors.forename: Jana
authors.initials: J
authors.lastname: Mártonová
authors.forename: Miloslav
authors.initials: M
authors.lastname: Ambruš
authors.forename: Alena
authors.initials: A
authors.lastname: Dohnalová
authors.forename: Martina
authors.initials: M
authors.lastname: Nedbalová
authors.forename: Anna
authors.initials: A
authors.lastname: Jandová
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002448:Cell Adhesion / Q000528:radiation effects; D004574:Electromagnetic Fields; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000528:radiation effects*; D055815:Young Adult