title: Comparison of four botulinum neurotoxin type A preparations in the treatment of hyperdynamic forehead lines in men: a pilot study.
abstract: BACKGROUND
  Botulinum neurotoxin type A (BTXA) offers a minimally invasive approach for the treatment of facial rhytides and has been well accepted by male patients. However, few comparative studies about the efficacy of the different BTXA preparations in this emerging group of patients are available.
  
  
  OBJECTIVE
  To access the efficacy of four BTXA preparations in the treatment of hyperdynamic forehead lines in men.
  
  
  METHODS
  Twelve male patients with a mean age of 30.5±5.26 years, with moderate or severe hyperdynamic forehead lines on a facial wrinkle scale (FWS), were involved in the study. Using an intra-individual controlled study design, either 17 mouse units (m.U) of Botox, Prosigne, and Xeomin or 51 Speywood units (s.U) of Dysport were applied to each side of a patient's forehead. Subjects with absent or mild forehead lines were considered responders. Study evaluations were performed monthly up to day 150.
  
  
  RESULTS
  All patients responded in a side-to-side evaluation and no asymmetries or differences in the degree of reduction of hyperdynamic forehead lines were noted at day 30 and day 60 (P=0.340). Analysis of all combined forehead sides treated with a given BTXA did not show statistically significant differences in terms of maintenance of improvement between different BTXA preparations at day 150 (P=0.528).
  
  
  CONCLUSIONS
  The data obtained in this study revealed a similar effectiveness of the BTXA preparations evaluated in the treatment of hyperdynamic forehead lines in men, when considering a dose-ratio of 1 m.U of Botox, Xeomin or Prosigne to 3 s.U of Dysport.
authors.affiliation: University Hospital of Brasilia, University of Brasilia, Brasilia, Brazil. orlando.unb@gmail.com
authors.forename: Orlando
authors.initials: O
authors.lastname: Oliveira de Morais
authors.forename: Eugênio
authors.initials: E
authors.lastname: Matos Reis-Filho
authors.forename: Larissa
authors.initials: L
authors.lastname: Vilela Pereira
authors.forename: Ciro
authors.initials: C
authors.lastname: Martins Gomes
authors.forename: Gilvan
authors.initials: G
authors.lastname: Alves
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004311:Double-Blind Method; D005546:Forehead; D006801:Humans; D008297:Male; D010865:Pilot Projects; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A