title: Gold nanomaterials conjugated with indocyanine green for dual-modality photodynamic and photothermal therapy.
abstract: Light-exposure-mediated higher temperatures that markedly accelerate the degradation of indocyanine green (ICG) in aqueous solutions by thermal decomposition have been a serious medical problem. In this work, we present the example of using gold nanorods (Au NRs) and gold nanoparticles (Au NPs) simultaneously serving as photodynamic and photothermal agents to destroy malignant cells. Au NRs and Au NPs were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and photothermal therapy (PTT). We also demonstrated that Au NRs and Au NPs conjugated with ICG displayed high chemical stability and acted as a promising diagnostic probe. Moreover, the photochemical destruction ability would have a gradually increase depending on different sizes of Au NPs. Due to its stability even via higher temperatures mediated by laser irradiation, the combination of PTT and PDT proved to be efficiently killing cancer cells as compared to PTT or PDT treatment alone and enhanced the effectiveness of photodestruction and was demonstrated to enhance its photostability. As a result, the preparation of Au-based nanomaterials conjugated with ICG as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.
authors.affiliation: Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan. activesitess@gmail.com
authors.forename: Wen-Shuo
authors.initials: WS
authors.lastname: Kuo
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Chang
authors.forename: Keng-Chi
authors.initials: KC
authors.lastname: Cho
authors.forename: Kuo-Chih
authors.initials: KC
authors.lastname: Chiu
authors.forename: Chi-Hsiang
authors.initials: CH
authors.lastname: Lien
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
authors.forename: Shean-Jen
authors.initials: SJ
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D010778:Photochemotherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D006046:Gold; D007208:Indocyanine Green