title: Fast T1 mapping determined using incomplete inversion recovery look-locker 3D balanced SSFP acquisition and a simple two-parameter model fit.
abstract: OBJECTIVE
  To evaluate a fast T1 mapping technique using incomplete inversion recovery 3D balanced steady-state free precession acquisition along with a two-parameter model fit.
  
  
  METHODS
  Using Bloch simulations, we explored the two-parameter model fit for data acquired using such an acquisition scheme. The parameter space over which the fit holds good was determined through simulations. A linear correction was derived for the R1* (1/T1*) values so determined. Two phantoms and six volunteers were scanned using the described technique. Comparison scans using full recovery as well as gold standard inversion recovery spin echo were also performed.
  
  
  RESULTS
  The two-parameter fit works exceedingly well over a large parameter space. T1 values in the phantoms showed an error of 4.9% and 39% before correction and 0.9% and 1.6% after correction. For the six volunteers, error in T1 value was 5.3% for white matter (WM) and 2.4% for gray matter (GM) after correction, while it was 11.2% and 18.2% before correction.
  
  
  CONCLUSIONS
  The work presented here allows for T1 map determination with higher resolution and shorter acquisition time than previously possible. The technique is especially well suited for GM/WM T1 mapping.
authors.affiliation: Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. gaind@cc.nih.gov
authors.forename: Neville D
authors.initials: ND
authors.lastname: Gai
authors.forename: John A
authors.initials: JA
authors.lastname: Butman
mesh_terms: D000465:Algorithms; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity