title: [Antidiabetes drug metformin is a donor of nitric oxide: ESR measurement of efficiency].
abstract: It is shown that metformin, which is a drug used for treatment of type 2 diabetes mellitus, metabolizes itself in vivo in the intestine and liver of mice with the release of nitric oxide. Subsequently the released nitric oxide forms paramagnetic mono- and dinitrosyl iron complexes which can be registered by EPR method. It is suggested that nitric oxide is just responsible for multifarious therapeutic action of metformin such as lowering of blood glucose level, reduction of arterial hypertension and other biological effects.
authors.forename: V A
authors.initials: VA
authors.lastname: Serezhenkov
authors.forename: I S
authors.initials: IS
authors.lastname: Kuznetsov
authors.forename: T I
authors.initials: TI
authors.lastname: Romantsova
authors.forename: M I
authors.initials: MI
authors.lastname: Kuznetsova
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D007501:Iron / Q000097:blood*; D008687:Metformin / Q000493:pharmacokinetics* / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000097:blood*; D020030:Nitric Oxide Donors / Q000493:pharmacokinetics* / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D020030:Nitric Oxide Donors; D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D008687:Metformin; D007501:Iron