title: Mn2+ dopant-controlled synthesis of NaYF4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery.
abstract: Pure dark red emission (650-670 nm) of NaYF(4):Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn(2+)) doping. In addition, the Mn(2+)-doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, P R China.
authors.forename: Gan
authors.initials: G
authors.lastname: Tian
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
authors.forename: Liangjun
authors.initials: L
authors.lastname: Zhou
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.forename: Shan
authors.initials: S
authors.lastname: Jin
authors.forename: Wenlu
authors.initials: W
authors.lastname: Ren
authors.forename: Gengmei
authors.initials: G
authors.lastname: Xing
authors.forename: Shoujian
authors.initials: S
authors.lastname: Li
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D004871:Erbium / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D049449:Luminescence; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D015018:Ytterbium / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C525362:sodium yttriumtetrafluoride; D008345:Manganese; D015019:Yttrium; D004871:Erbium; D004317:Doxorubicin; D015018:Ytterbium; D005459:Fluorides