title: Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.
abstract: Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 -44C > G, -52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFβ1 -44CG genotype and DEFβ1 [G;G] haplotype correlated with a better clinical outcome.
authors.affiliation: Department of Oncology and Surgical Sciences, AIDS Reference Centre, University of Padova, Padua, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Freguja
authors.forename: Ketty
authors.initials: K
authors.lastname: Gianesin
authors.forename: Paola
authors.initials: P
authors.lastname: Del Bianco
authors.forename: Sandro
authors.initials: S
authors.lastname: Malacrida
authors.forename: Osvalda
authors.initials: O
authors.lastname: Rampon
authors.forename: Marisa
authors.initials: M
authors.lastname: Zanchetta
authors.forename: Carlo
authors.initials: C
authors.lastname: Giaquinto
authors.forename: Anita
authors.initials: A
authors.lastname: De Rossi
mesh_terms: D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007223:Infant; D007231:Infant, Newborn; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
chemical_list: C406407:DEFB1 protein, human; C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D023083:beta-Defensins