title: The role of resistin in colorectal cancer.
abstract: BACKGROUND
  To date the role of resistin in colorectal cancer (CRC) is far from being elucidated. The aim of this study was to investigate the association between serum resistin levels and CRC in relation to known risk/protective factors including anthropometric, metabolic, inflammatory parameters as well as lifestyle individual characteristics.
  
  
  METHODS
  40 CRC patients and 40 controls were enrolled. Body weight, height, waist circumference and blood pressure were recorded. Fasting plasma glucose, lipids, C-reactive protein (CRP) and resistin levels were measured. Metabolic Syndrome (MS) was defined according to the harmonized definition.
  
  
  RESULTS
  Resistin levels were significantly higher in CRC patients than in controls (p=0.028) and gradually increased with tumor stage progression (p=0.042). A high resistin level was statistically significant determinant of CRC after adjusting for age, sex, body mass index and lifestyle parameters (p=0.029). Resistin showed a strong association with CRP levels (p ≤ 0.0001). In stepwise regression analysis CRP remained the only independent predictor of both resistin levels (p=0.001) and CRC risk (p=0.021).
  
  
  CONCLUSIONS
  These results clarify the nature of the association between resistin and CRC risk suggesting that the proinflammatory state of cancer, rather than the clinical diagnosis of CRC itself or its link with obesity and MS, may govern this association.
authors.affiliation: Sezione di Biochimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Università di Verona, Verona, Italy. elisa.danese@ospedaleuniverona.it
authors.forename: Elisa
authors.initials: E
authors.lastname: Danese
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Minicozzi
authors.forename: Sara
authors.initials: S
authors.lastname: Bonafini
authors.forename: Orazio
authors.initials: O
authors.lastname: Ruzzenente
authors.forename: Matteo
authors.initials: M
authors.lastname: Gelati
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Manzoni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Guidi
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D052243:Resistin / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D008055:Lipids; C499624:RETN protein, human; D052243:Resistin; D002097:C-Reactive Protein