title: Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers.
abstract: The digestive stability of two natural antioxidant compounds present in virgin olive oil, hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-Ac) and a new series of hydroxytyrosyl ethers (methyl, ethyl and butyl hydroxytyrosyl ethers) was evaluated by a simulated digestion procedure. High recovery of all compounds after gastric digestion was obtained, although they showed a statistically significant lower stability after pancreatic-bile salts digestion. HTy-Ac was partially hydrolyzed into free HTy, whereas after intestinal digestion, HTy was converted into 3,4-dihydroxyphenyl acetic acid (DOPAC), and HTy-Ac was hydrolyzed to HTy and subsequently transformed into DOPAC. In contrast, no chemical modification of hydroxytyrosyl ethers during in vitro digestion was observed. In summary, HTy, HTy-Ac and hydroxytyrosyl ethers show high and interesting digestive stability and the new synthetic hydroxytyrosyl ethers showed enhanced chemical stability compared to HTy and HTy-Ac.
authors.affiliation: IFAPA Centro Venta del Llano , Road Bailén-Motril, Mengibar, Jaén, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Pereira-Caro
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sarriá
authors.forename: Andrés
authors.initials: A
authors.lastname: Madrona
authors.forename: José Luis
authors.initials: JL
authors.lastname: Espartero
authors.forename: María E
authors.initials: ME
authors.lastname: Escuderos
authors.forename: Laura
authors.initials: L
authors.lastname: Bravo
authors.forename: Raquel
authors.initials: R
authors.lastname: Mateos
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000737:chemistry; D000085:Acetates / Q000737:chemistry*; D000975:Antioxidants; D001647:Bile Acids and Salts / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D006868:Hydrolysis; D015394:Molecular Structure; D000069463:Olive Oil; D010194:Pancreatin / Q000737:chemistry*; D010434:Pepsin A / Q000737:chemistry*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry
chemical_list: D000085:Acetates; D000975:Antioxidants; D001647:Bile Acids and Salts; D002396:Catechols; D004987:Ethers; D000069463:Olive Oil; D010938:Plant Oils; C524604:hydroxytyrosyl acetate; D015102:3,4-Dihydroxyphenylacetic Acid; C005975:3,4-dihydroxyphenylethanol; D010194:Pancreatin; D010434:Pepsin A; D010626:Phenylethyl Alcohol