title: Minor salivary gland malignancies in the pediatric population.
abstract: BACKGROUND
  Minor salivary gland malignancies in children are rare and data on treatment and outcomes are limited.
  
  
  METHODS
  A retrospective chart review of all pediatric patients with the pathologic diagnosis of minor salivary gland malignancy at a tertiary care cancer hospital was used to conduct this review.
  
  
  RESULTS
  From 1952 to 2006, 35 children with minor salivary gland cancers were treated at The University of Texas MD Anderson Cancer Center. Mean age was 15.2 +/- 2.9 years with a slight female predominance. Recurrence occurred in 4 patients and was significantly associated with positive margins, advanced stage, and high histologic grade. Overall survival (OS) and disease-specific survival (DSS) were 89.3% and 88.4%, respectively, at 5 years. Advanced stage, positive margins, and high grade were associated with adverse survival.
  
  
  CONCLUSIONS
  Minor salivary gland malignancies in children are rare. Surgical resection with clear margins yields excellent outcomes in patients with low-intermediate grade and early stage tumors. Patients with high-grade malignancies do poorly despite multimodality therapy.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Chad
authors.initials: C
authors.lastname: Galer
authors.forename: Alfredo A
authors.initials: AA
authors.lastname: Santillan
authors.forename: Daniel
authors.initials: D
authors.lastname: Chelius
authors.forename: Winston
authors.initials: W
authors.lastname: Huh
authors.forename: Adel
authors.initials: A
authors.lastname: El-Naggar
authors.forename: Ehab
authors.initials: E
authors.lastname: Hanna
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kupferman
mesh_terms: D000293:Adolescent; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D012470:Salivary Glands, Minor / Q000473:pathology*; D016019:Survival Analysis; D016896:Treatment Outcome