title: Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
abstract: Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Dianren
authors.initials: D
authors.lastname: Xia
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Wang
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katoh
authors.forename: Raymond N
authors.initials: RN
authors.lastname: DuBois
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism; D019175:DNA Methylation / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000187:drug effects; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D015854:Up-Regulation; D000097584:DNA Methyltransferase 3B
chemical_list: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; D015232:Dinoprostone; D000097584:DNA Methyltransferase 3B