title: Tumor spectrum in lynch syndrome, DNA mismatch repair system and endogenous carcinogens.
abstract: Inactivation of Mismatch Repair genes in Lynch Syndrome, caused by inherited mutations, decreases the ability to repair DNA errors throughout life. This deficit may allow the development of any tumor type. Nevertheless, the Syndrome develops a specific tumor spectrum associated with the disease. We think that such spectrum of tumors would be related to the action of certain endogenous carcinogens such as bile acids and estrogens that aggravate the inherited defect.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Medina-Arana
authors.forename: Luciano
authors.initials: L
authors.lastname: Delgado
authors.forename: Alberto
authors.initials: A
authors.lastname: Bravo
authors.forename: Juana
authors.initials: J
authors.lastname: Martín
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Fernández-Peralta
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González-Aguilera
mesh_terms: D001647:Bile Acids and Salts / Q000009:adverse effects*; D002273:Carcinogens; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D053843:DNA Mismatch Repair / Q000235:genetics*; D004967:Estrogens / Q000009:adverse effects*; D005838:Genotype; D006801:Humans; D053842:Microsatellite Instability; D009154:Mutation; D010641:Phenotype
chemical_list: D001647:Bile Acids and Salts; D002273:Carcinogens; D004967:Estrogens