title: Remarkable enantioselective α-amination in 1-phenyl-2-(N-alkylamino)-1-propanol.
abstract: (1R,2R)-1-Phenyl-1-alkyl/arylamino-2-(N-alkylamino)propane hydrochloride salts have been synthesized with high degree of enantiomeric purity from (1S,2R)-(+)-1-phenyl-2-(N-alkylamino)-1-propanol through the corresponding chloro derivatives. This reaction sequence involves three inversions with overall inversion of configuration at C-1.
authors.affiliation: Research and Development Centre, Malladi Drugs and Pharmaceuticals Ltd., No. 788/1, Irulapalayam, Kuthambakkam, Chennai 602107, Tamil Nadu, India.
authors.forename: Borkatte N
authors.initials: BN
authors.lastname: Hitesh Kumar
authors.forename: Velayutham
authors.initials: V
authors.lastname: Murugesan
authors.forename: Tangirala
authors.initials: T
authors.lastname: Prakasam
authors.forename: Pathangi S
authors.initials: PS
authors.lastname: Srinivasan
authors.forename: Devalla V
authors.initials: DV
authors.lastname: Ramana
mesh_terms: D000433:1-Propanol / Q000737:chemistry*; D000586:Amination; D054879:Halogenation; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000433:1-Propanol