title: Multicentric giant cell tumor: metachronous central and peripheral involvement.
abstract: Giant cell tumors are rare in the head and neck region. The most frequently involved sites of giant cell lesions in the head and neck are the maxilla and mandible, whereas the sphenoid and temporal bones are rarely involved. This tumor is usually located in the long bones of limbs. Reparative granuloma and brown tumor of hyperparathyroidism must be included in the differential diagnosis. Here we report the clinical and radiologic findings of a multicentric giant cell tumor with skull base involvement in a female patient. This case report demonstrates the similar pathophysiology of peripheral and central giant cell tumors.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tehran University of Medical Sciences and Health Services, Imam Khomeini Medical Complex, Dr. Gharib Ave., Keshavarz Blvd., Tehran, Iran.
authors.forename: Alireza Karimi
authors.initials: AK
authors.lastname: Yazdi
authors.forename: Amir A
authors.initials: AA
authors.lastname: Sazgar
authors.forename: Ali
authors.initials: A
authors.lastname: Kouhi
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000628:therapy; D002348:Carpal Bones; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D006811:Humerus; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000628:therapy; D012447:Sacrum; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000628:therapy