title: Pubertal muscle mass and diabetes markers in Chinese adolescents.
abstract: OBJECTIVE
  Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents.
  
  
  METHODS
  In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's "Children of 1997" birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan.
  
  
  RESULTS
  Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass.
  
  
  CONCLUSIONS
  Environmentally driven muscle mass acquisition at puberty could influence diabetes.
authors.affiliation: Life Course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Shi Lin
authors.initials: SL
authors.lastname: Lin
authors.forename: So Lun
authors.initials: SL
authors.lastname: Lee
authors.forename: Lai Ling
authors.initials: LL
authors.lastname: Hui
authors.forename: Shiu Lun
authors.initials: SL
authors.lastname: Au Yeung
authors.forename: Michael A
authors.initials: MA
authors.lastname: Tse
authors.forename: Gabriel M
authors.initials: GM
authors.lastname: Leung
authors.forename: C Mary
authors.initials: CM
authors.lastname: Schooling
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology*; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D006723:Hong Kong; D006801:Humans; D007328:Insulin / Q000097:blood; D016014:Linear Models; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology* / Q000502:physiology; D011627:Puberty / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone