title: Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women.
abstract: We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.
authors.affiliation: Department of Anatomy, Veterinary School, University of Bristol, Bristol, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Hulin-Curtis
authors.forename: J L
authors.initials: JL
authors.lastname: Bidwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Perry
mesh_terms: D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D020370:Osteoarthritis, Knee / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
chemical_list: D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human