title: [Obesity and gallbladder diseases].
abstract: Obesity is an important health problem in the world and related to many critical diseases, such as diabetes, cardiovascular disease, and metabolic syndrome. Obesity leads to fat infiltration of multiple organs and infiltrated adipose tissue produces many cytokines resulting in the dysfunction of organs such as the gallbladder. In the biliary diseases, obesity and overweight have been known as a major risk factor for gallstones. According to current studies, obesity, insulin resistance, hyperinsulinemia, and metabolic syndrome are related to various gallbladder diseases including gallbladder stones, cholecystitis, gallbladder polyps, and gallbladder cancers. We reviewed further literature on the obesity and gallbladder diseases, in aspects of epidemiology, mechanism, pathology and prevention.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Seung Uk
authors.initials: SU
authors.lastname: Jeong
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Lee
mesh_terms: D015992:Body Mass Index; D002764:Cholecystitis / Q000209:etiology; D015444:Exercise; D005705:Gallbladder Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D005706:Gallbladder Neoplasms / Q000453:epidemiology / Q000209:etiology; D042882:Gallstones / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006946:Hyperinsulinism; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D015431:Weight Loss
chemical_list: D000960:Hypolipidemic Agents; D014580:Ursodeoxycholic Acid