title: Neuroendocrinology and ovarian aging.
abstract: The ovarian aging, a dynamic process that precedes the clinical manifestations of menopause, can be assessed using ovarian reserve biomarkers. It is well-known that reproduction during the later years of reproductive life has known limitations that challenge the success of assisted reproduction. Therefore, a review of the neuroendocrine modifications during this critical period of reproductive life may help to elucidate the ovarian aging process and its impact on reproduction. In this review, we aim to further the discussion of neuroendocrine changes taking place during the ovarian aging process that may impact reproductive function.
authors.affiliation: Instituto de Investigaciones Materno Infantil, Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile. ldevoto@med.uchile.cl
authors.forename: Luigi
authors.initials: L
authors.lastname: Devoto
authors.forename: Alberto
authors.initials: A
authors.lastname: Palomino
authors.forename: Pablo
authors.initials: P
authors.lastname: Céspedes
authors.forename: Paulina
authors.initials: P
authors.lastname: Kohen
mesh_terms: D000375:Aging / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D008593:Menopause / Q000097:blood / Q000378:metabolism / Q000502:physiology; D009452:Neuroendocrinology; D009490:Neurosecretory Systems / Q000378:metabolism / Q000502:physiology*; D010053:Ovary / Q000378:metabolism / Q000502:physiology*; D012098:Reproduction / Q000235:genetics / Q000502:physiology
chemical_list: D007987:Gonadotropin-Releasing Hormone