title: Total synthesis of (-)-sacidumlignans B and D.
abstract: The first total synthesis of naturally occurring sacidumlignans A (1), B (2), and D (4) was executed and the absolute configuration of 2 and 4 was determined. A diastereoselective α- methylation of a lactone was used as the key step for the control of the chiral centers of the central lignan core. An acid mediated dehydrative cyclization of an aldehyde to construct the dihydronaphthalene unit of 2 and the aromatization of the intermediate dihydronaphthalene derivative to synthesize 1 are the key reactions employed in this regard.
authors.affiliation: National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune 411 008, India.
authors.forename: Jeetendra Kumar
authors.initials: JK
authors.lastname: Rout
authors.forename: C V
authors.initials: CV
authors.lastname: Ramana
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D007783:Lactones / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007783:Lactones; D017705:Lignans; C572510:sacidumlignan B; C561165:sacidumlignan D