title: Recycling side-effects into clinical markers for drug repositioning.
abstract: Side-effects are the unintended consequence of therapeutic treatments, but they can also be seen as valuable read-outs of drug effects in humans; these effects are difficult to infer or predict from pre-clinical models. Indeed, some studies suggest that drugs with similar side-effect profiles may also share therapeutic properties through related mechanisms of action. A recent publication exploits this concept to systematically investigate new indications for already marketed drugs, and presents a strategy to get the most out of the tiny portion of chemicals that have proved to be effective and safe.
authors.affiliation: Joint IRB-BSC Program in Computational Biology, Institute for Research in Biomedicine (IRB) Barcelona, c/Baldiri Reixac 10-12, 08028 Barcelona, Spain. patrick.aloy@irbbarcelona.org.
authors.forename: Miquel
authors.initials: M
authors.lastname: Duran-Frigola
authors.forename: Patrick
authors.initials: P
authors.lastname: Aloy