title: Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.
abstract: The first organocatalytic asymmetric assembly of Morita-Baylis-Hillman carbonates of isatins and α-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr >95:5).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Peng
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007211:Indoles; D058115:Lewis Bases; D000078183:Oxindoles; C022960:2-oxindole; C019257:angelica lactone; D015107:4-Butyrolactone