title: Sperm cryopreservation before cancer treatment: a 15-year monocentric experience.
abstract: Sperm banking is an important procedure to preserve fertility before cancer therapy. The aim of this study was to comprehensively analyse cryopreservation activity retrospectively for 1080 patients referred to the sperm bank for sperm cryopreservation before cancer treatment. This study included 1007 patients diagnosed with testicular cancer (TC) (41.7%), lymphoma (26%), other haematological cancers (9.4%) or other types of cancer (22.8%); of these, 29 patients did not produce any semen sample and cryopreservation was impossible for 67 patients. Semen characteristics before treatment were within normal ranges, except moderate asthenospermia. Sperm concentration was significantly lower in TC than in non-TC. Straws from 57 patients (6.3%) were used in assisted reproductive technologies, which led to a 46.8% cumulative birth rate. Straws were destroyed for 170 patients (18.7%) and 140 patients performed semen analyses after cancer therapy. After an average delay of 22.5 months after the end of therapy, 43 patients (30.7%) exhibited azoospermia. This study of a large population of cancer patients revealed a high level of successful sperm storage. Utilization of cryopreserved spermatozoa led to good chances of fatherhood. Nevertheless, sperm banks should be aware of the low rates of straw use and straw destruction by cancer patients.
authors.affiliation: Aix-Marseille Université, AP-HM La Conception, CECOS-Laboratoire de Biologie de la Reproduction, Pôle de Gynécologie-Obstétrique et Reproduction, 147, Boulevard Baille, 13005 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Bizet
authors.forename: J
authors.initials: J
authors.lastname: Saias-Magnan
authors.forename: E
authors.initials: E
authors.lastname: Jouve
authors.forename: J M
authors.initials: JM
authors.lastname: Grillo
authors.forename: G
authors.initials: G
authors.lastname: Karsenty
authors.forename: C
authors.initials: C
authors.lastname: Metzler-Guillemain
authors.forename: J
authors.initials: J
authors.lastname: Perrin
mesh_terms: D000293:Adolescent; D000328:Adult; D015925:Cryopreservation / Q000379:methods*; D059247:Fertility Preservation / Q000706:statistics & numerical data*; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D055101:Semen Analysis; D013094:Spermatozoa; D013736:Testicular Neoplasms / Q000150:complications / Q000628:therapy