title: Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study.
abstract: BACKGROUND
  In the current study, we aimed to investigate the influences of pentoxifylline, which increases the flexibility, deformability and viscosity of the erythrocytes while reducing the aggregation abilities of the platelets, and vinpocetine, which has neuroprotective and antioxidant effects, on healing of colonic anastomoses.
  
  
  METHODS
  We used 30 Albino Wistar rats. Subjects were divided into three groups of 10 rats each. Colonic ischemia was established in all the groups. Following colonic transection, anastomosis was performed. Group A received intraperitoneal saline, whereas Group B and Group C received pentoxifylline and vinpocetine, respectively. The subjects were sacrificed on the postoperative 5th day by ether anesthesia, and their colonic bursting pressures were measured. The anastomotic area was excised for hydroxyproline assay and histopathologic examination.
  
  
  RESULTS
  According to intergroup comparisons, colonic bursting pressure was found to be higher in the treatment groups than in the control group; however, the difference was not statistically significant. Intergroup comparisons regarding tissue hydroxyproline levels showed statistically significant differences between Groups A and B, Groups A and C and Groups B and C.
  
  
  CONCLUSIONS
  Similar to pentoxifylline, vinpocetine was also shown to have a beneficial effect over ischemic colon anastomoses.
authors.affiliation: Department of General Surgery, Yüzüncü Yıl Univesity, Faculty of Medicine, Van, Turkey. azizsumer2002@yahoo.com
authors.forename: Aziz
authors.initials: A
authors.lastname: Sümer
authors.forename: Ediz
authors.initials: E
authors.lastname: Altınlı
authors.forename: Serkan
authors.initials: S
authors.lastname: Senger
authors.forename: Neşet
authors.initials: N
authors.lastname: Köksal
authors.forename: Ender
authors.initials: E
authors.lastname: Onur
authors.forename: Ersan
authors.initials: E
authors.lastname: Eroğlu
authors.forename: Pembegül
authors.initials: P
authors.lastname: Güneş
mesh_terms: D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000517:prevention & control*; D000818:Animals; D003106:Colon / Q000098:blood supply / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D007511:Ischemia / Q000517:prevention & control*; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D010431:Pentoxifylline