title: Histopathologic evaluation of neurogenic pulmonary edema after subarachnoid hemorrhage in rabbits.
abstract: OBJECTIVE
  To investigate the effects of subarachnoid hemorrhage (SAH) on lung tissue.
  
  
  METHODS
  We conducted this study on 20 rabbits in the Ataturk University Medical Faculty, Erzurum, Turkey in 2005. Experimental SAH was applied to all animals under general anesthesia. After 20 days, all animals were sacrificed. Their lungs were examined histopathologically.
  
  
  RESULTS
  Foamy hemorrhagic parenchymal lesions, alveolar rupture, and subintimal fluid collection in the pulmonary vasculature were observed in the lungs of the non-surviving animals. However, minimal changes were found in the lungs of the surviving animals (p<0.01).
  
  
  CONCLUSIONS
  Our results suggest that luminal narrowing of the lung vessels due to subintimal fluid collection plays an important role in the development of pulmonary hypertension and neurogenic pulmonary edema in SAH.
authors.affiliation: Department of Pathology, School of Medicine, Ataturk University, Erzurum, Turkey. Tel. +90 (542) 232 3669. Fax. +90 442 3166340. E-mail: mkizilkaya65@hotmail.com.
authors.forename: Cemal
authors.initials: C
authors.lastname: Gundogdu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kizilkaya
authors.forename: Mehmet D
authors.initials: MD
authors.lastname: Aydin
authors.forename: Canan
authors.initials: C
authors.lastname: Atalay
authors.forename: Zuhtu U
authors.initials: ZU
authors.lastname: Sevimli