title: Synthesis of δ-bromo γ,δ-unsaturated carbonyl compounds via palladium-catalyzed bromoalkylation of alkynoates.
abstract: Palladium-catalyzed regio- and stereoselective intermolecular tandem reaction of electron-deficient alkynes, CuBr(2), and allylic alcohol to synthesize δ-bromo-γ,δ-unsaturated carbonyls was developed. A mechanism involving bromopalladation of alkyne, followed by insertion of allylic alcohol and allylic hydrogen shift, is proposed. The shift of allylic hydrogen is the rate-limiting step in this reaction.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Wen
authors.forename: Liangbin
authors.initials: L
authors.lastname: Huang
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Huoji
authors.initials: H
authors.lastname: Chen