title: Sex differences in the association between level of childhood interleukin-6 and insulin resistance in adolescence.
abstract: The purpose of this study was to determine whether levels of interleukin-6 (IL-6) in childhood are related to insulin resistance in adolescence. Further, to explore how fatness and cardiorespiratory fitness (VO(2peak)) moderate this relationship. Methods. 292 nine-year-old children (n = 292) were followed for 4 years. Anthropometrics and VO(2peak) were measured. Fasting blood samples were analyzed for IL-6, insulin, and glucose. Homeostasis model assessment (HOMA-IR) was used as a measure of insulin resistance. Results. For girls but not boys, levels of IL-6 at age 9 yrs correlated with HOMA-IR at age 13 yrs: r = 0.223, P = 0.008. Girls with IL-6 levels within the highest quartile at age 9 yrs had an odds ratio of 3.68 (CI = 1.58-8.57) being in the highest quartile of HOMA-IR four years later. Conclusion. In this cohort, IL-6 levels in childhood were related to insulin resistance in adolescence, but only for girls.
authors.affiliation: Centre for Research in Childhood Health, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. anbugge@health.sdu.dk
authors.forename: Anna
authors.initials: A
authors.lastname: Bugge
authors.forename: Bianca
authors.initials: B
authors.lastname: El-Naaman
authors.forename: Robert
authors.initials: R
authors.lastname: G McMurray
authors.forename: Karsten
authors.initials: K
authors.lastname: Froberg
authors.forename: Claus Henrik
authors.initials: CH
authors.lastname: Nielsen
authors.forename: Klaus
authors.initials: K
authors.lastname: Müller
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D016015:Logistic Models; D008297:Male; D010101:Oxygen Consumption; D012727:Sex Characteristics
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6