title: VEGFA+936C/T and -634G/C polymorphisms and gastric cancer risk: a meta-analysis.
abstract: To estimate the association of vascular endothelial growth factor A (VEGFA) +936C/T and -634G/C polymorphisms and gastric cancer (GC) risk, a meta-analysis was performed. A total of nine studies were identified with 2,281 GC cases and 2,820 controls. This meta-analysis indicated significant associations between the VEGFA -634G/C polymorphism and GC risk were found for GC versus GG (OR 1.21, 95% CI 1.03-1.42) and GG+CC versus GC (OR 0.78, 95% CI 0.68-0.90) overall, for GC versus GG (OR 1.68, 95% CI 1.19-2.35) and GC+CC versus GG (OR 1.54, 95% CI 1.13-2.10) among Europeans, and for GG+CC versus GC (OR 0.82, 95% CI 0.70-0.96) among Asians. No association were observed between GC risk and the variant genotypes of VEGFA +936C/T in different genetic models. In summary, the results suggest that the VEGFA -634G/C polymorphism may contribute to GC susceptibility.
authors.affiliation: Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Shaochuang
authors.initials: S
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A