title: Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
abstract: The protocols described in this unit are used to assess the effects of new chemical entities on arrhythmias in the guinea pig. In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest. Imipramine precipitates the occurrence of arrhythmias, whereas propranolol shows protection against them.
authors.affiliation: Porsolt and Partners Pharmacology, Boulogne-Billancourt, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guillaume
authors.forename: Daniel
authors.initials: D
authors.lastname: Provost
authors.forename: Pierre
authors.initials: P
authors.lastname: Lacroix
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D002985:Clinical Protocols; D004077:Digoxin / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D004077:Digoxin; D011433:Propranolol; D007099:Imipramine