title: Thymomaptysis: unusual presentation of invasive thymoma.
abstract: Symptomatic thymomas are characterized by non-specific thoracic symptoms or symptoms related to associated para-thymic syndromes. We report the case of a 56-year old Caucasian male who was affected by invasive (Masaoka IVA) WHO mixed AB-B2 thymoma after the elimination through the sputum of a fragment of tumour vegetating in the left upper lobar bronchus. The patient received multimodal treatment consisting of neoadjuvant cisplatinum-based polychemiotherapy, radical surgical resection ('en bloc' thymectomy, thymomectomy and pulmonary left upper lobe exeresis and pleural implants resection) and subsequent mediastinal radiation therapy. At 18-month follow-up, the patient is alive and disease-free.
authors.affiliation: Thoracic Surgery Unit, University of Eastern Piedmont, Novara, Italy. ottaviorena@libero.it
authors.forename: Ottavio
authors.initials: O
authors.lastname: Rena
authors.forename: Antonio
authors.initials: A
authors.lastname: Ramponi
authors.forename: Alberto
authors.initials: A
authors.lastname: Roncon
authors.forename: Caterina
authors.initials: C
authors.lastname: Casadio
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003371:Cough / Q000209:etiology* / Q000473:pathology; D006469:Hemoptysis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D018714:Radiotherapy, Adjuvant; D013183:Sputum; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome