title: JAK/STAT: the enigma within the mystery of NMDAR-LTD.
abstract: In this issue of Neuron, Nicolas et al. (2012) show that JAK2/STAT3 signaling, a canonical pathway for transmitting information from the cell membrane to the nucleus, is critical for NMDAR-LTD, even in the absence of new DNA transcription.
authors.affiliation: Departments of Physiology, Pharmacology, and Neurology, State University of New York Downstate Medical Center, The Robert F. Furchgott Center for Neural and Behavioral Science, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. tsacktor@downstate.edu
authors.forename: Todd C
authors.initials: TC
authors.lastname: Sacktor
mesh_terms: D000818:Animals; D053612:Janus Kinases / Q000378:metabolism*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*
chemical_list: D050791:STAT Transcription Factors; D053612:Janus Kinases