title: The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration.
abstract: OBJECTIVE
  To clarify the association of cluster of differentiation 36 (CD36) variants with polypoidal choroidal vasculopathy (PCV) and compare them with those in typical neovascular age-related macular degeneration (tAMD).
  
  
  METHODS
  We included 349 Japanese AMD patients (210 PCV, 139 tAMD) and 198 age-matched controls. Four tag single-nucleotide polymorphisms (SNPs)-rs10499862, rs3173798, rs3211883, and rs3173800-in the CD36 region were genotyped using the TaqMan assay. Allelic and genotypic frequencies of the SNPs were tested.
  
  
  RESULTS
  Although none of the SNPs tested were associated with PCV, the allelic frequencies of rs3173798 and rs3173800 were significantly different between PCV and tAMD patients. Genotype association analysis demonstrated different associations of these two SNPs between PCV and tAMD in the genotype model. Haplotype analysis revealed that the association of the major haplotype (T-T-T-T) at four selected SNPs in CD36 differed significantly between PCV and tAMD patients.
  
  
  CONCLUSIONS
  The CD36 region may be associated with the difference in genetic susceptibility for PCV and tAMD.
authors.affiliation: Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Bessho
authors.forename: Shigeru
authors.initials: S
authors.lastname: Honda
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kondo
authors.forename: Sentaro
authors.initials: S
authors.lastname: Kusuhara
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Tsukahara
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018955:CD36 Antigens / Q000235:genetics; D016022:Case-Control Studies; D020256:Choroidal Neovascularization / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D018955:CD36 Antigens