title: Anti-heat shock protein 27 titers and oxidative stress levels are elevated in patients with valvular heart disease.
abstract: We studied the immune responses to heat shock protein (Hsp)-27 and pro-oxidant-antioxidant balance (PAB) values in patients with valvular heart disease, but free of angiographically evident coronary artery disease (CAD). Patients who were candidates for valvuloplasty surgery and 30 healthy matched controls were recruited. The anti-Hsp-27 antibody titers were 0.35 ± 0.04 absorbency units (AU) in the valvuloplasty group, being significantly higher than for the controls (0.11 ± 0.02 AU; P < .05). The PAB values were significantly higher in cases (134.67 ± 13.69 Hamidi-Koliakos(HK) unit) when compared with controls (49.78 ± 6.75 HK unit; P < .05). In cases, the ejection fraction was inversely correlated with anti-Hsp-27 antibody (P < .05) but was not significantly related to PAB values (P > .05). Based on the echocardiographic findings, the patients had no evident heart failure, but the high levels of anti-Hsp-27 and PAB values in patients with valvular heart disease may indicate that these variables can be used as markers of heart failure. However, a longitudinal study is required to confirm this hypothesis.
authors.affiliation: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science (MUMS), Mashhad, Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Rahsepar
authors.forename: Asadollah
authors.initials: A
authors.lastname: Mirzaee
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moodi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Ali
authors.initials: A
authors.lastname: Eshraghi
authors.forename: Maryam-Sadat
authors.initials: MS
authors.lastname: Alavi
authors.forename: Laya
authors.initials: L
authors.lastname: Zarrabi
authors.forename: Hossein
authors.initials: H
authors.lastname: Pourghadamyari
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Paydar
authors.forename: Roshanak
authors.initials: R
authors.lastname: Khojasteh
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mousavi
authors.forename: Nadia
authors.initials: N
authors.lastname: Kia
authors.forename: Maral
authors.initials: M
authors.lastname: Amini
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000328:Adult; D000368:Aged; D063126:Balloon Valvuloplasty; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D006349:Heart Valve Diseases / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012307:Risk Factors; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D017382:Reactive Oxygen Species