title: Osteogenesis of mineralized collagen bone graft modified by PLA and calcium sulfate hemihydrate: in vivo study.
abstract: In this study, the biocompatibility and bone regeneration performance of nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA) and nano-hydroxyapatite/collagen/calcium sulfate hemihydrate (nHAC/CSH) as bone-filling materials were evaluated and compared in a critical box-shaped defect model in the mandible of the rabbits. In vivo results indicated that there was significant difference in early bone remodeling between two types of bone substitutes. nHAC/PLA has shown excellent biocompatibility, but no adequate handling properties. The addition of CSH to nHAC provided better manipulability compared to nHAC/PLA. Furthermore, nHAC/CSH possesses superior properties in restoring critical-sized bone defects of maxillofacial region at the early stage of remodeling over nHAC/PLA. Our results suggested that nHAC/CSH could be an alternative to the conventionally used bone tissue engineering materials.
authors.affiliation: State Key Laboratory of New Ceramic and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.forename: Huan-Ye
authors.initials: HY
authors.lastname: Liu
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Lian
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Fu-Zhai
authors.initials: FZ
authors.lastname: Cui
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000379:methods*; D002113:Calcification, Physiologic; D002133:Calcium Sulfate; D003094:Collagen; D017886:Durapatite; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D010012:Osteogenesis; D011091:Polyesters; D011817:Rabbits; D023822:Tissue Engineering; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C033616:poly(lactide); D003094:Collagen; D017886:Durapatite; D002133:Calcium Sulfate