title: Protective effects of beta glucan and gliclazide on brain tissue and sciatic nerve of diabetic rats induced by streptozosin.
abstract: There have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.
authors.affiliation: Department of Pharmacology and Toxicology, Veterinary Faculty, Dicle University, Diyarbakir, Turkey. alpharun@gmail.com
authors.forename: Harun
authors.initials: H
authors.lastname: Alp
authors.forename: Sefer
authors.initials: S
authors.lastname: Varol
authors.forename: Muhammet Murat
authors.initials: MM
authors.lastname: Celik
authors.forename: Murat
authors.initials: M
authors.lastname: Altas
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Orhan
authors.initials: O
authors.lastname: Tokgoz
authors.forename: Mehmet Halis
authors.initials: MH
authors.lastname: Tanrıverdi
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Uzar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D054022:Cerebrum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D005907:Gliclazide / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D011509:Proteoglycans; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D013311:Streptozocin; D047071:beta-Glucans / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D009419:Nerve Tissue Proteins; D011509:Proteoglycans; D047071:beta-Glucans; C064197:beta-1,6-glucan; C010770:polysaccharide-K; D013311:Streptozocin; D002374:Catalase; C572204:Pon1 protein, rat; D043303:Aryldialkylphosphatase; D005907:Gliclazide