title: [Pharmacokinetics of hemantane in rats].
abstract: The pharmacokinetics ofhemantane after administration in different ways has been studied in rats. It is established that hemantane introduced both orally (p.o.) and intravenously (i.v.) is very intensively metabolized, with the main metabolites characterized by m/z = 250 and 266 and detected for 6 hours after the administration in both ways. Hemantane shows high rate of permeability into its target organ--brain--whereas the permeation of its metabolites is extremely low. The absolute bioavailability ofhemantane upon p.o. administration was 14.1%. The substance is subject to the "first-pass effect". The unchanged substance was determined in daily urine and feces in very small fractions of the administered dose: 0.23% in urine and 0.08% in feces after i.v. administration and 0.02% in feces after p.o. administration. Thus, it may be concluded that the substance is completely absorbed in rats from the gastro-intestinal tract into systemic blood circulation.
authors.forename: E A
authors.initials: EA
authors.lastname: Litvin
authors.forename: D V
authors.initials: DV
authors.lastname: Bastrygin
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: K V
authors.initials: KV
authors.lastname: Alekseev
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
mesh_terms: D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001682:Biological Availability; D001711:Biotransformation; D001923:Brain Chemistry; D002853:Chromatography, Liquid; D005243:Feces / Q000737:chemistry; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D053719:Tandem Mass Spectrometry; D014018:Tissue Distribution
chemical_list: D000978:Antiparkinson Agents; C526127:hemantane; D000218:Adamantane