title: Type B aortic dissection after the use of tadalafil.
abstract: A 63-year-old male patient with a type B aortic dissection after the use of tadalafil, a phosphodiesterase type 5 inhibitor, is presented. The possible role of a novel predisposing factor--sexual activity combined with tadalafil--is reviewed. This report and three other cases add a new dimension to the known predisposing factors such as chronic systemic hypertension, hereditary connective tissue diseases- and congenital aortic valve diseases. However, the precise role of phosphodiesterase type 5 inhibitors in the pathophysiology of aortic dissection remains unknown.
authors.affiliation: Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Lameijer
authors.forename: Ignace F J
authors.initials: IF
authors.lastname: Tielliu
authors.forename: Mels F
authors.initials: MF
authors.lastname: van Driel
authors.forename: Clark J
authors.initials: CJ
authors.lastname: Zeebregts
mesh_terms: D000208:Acute Disease; D000784:Aortic Dissection / Q000139:chemically induced* / Q000601:surgery; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D001019:Aortic Rupture / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D002243:Carbolines / Q000009:adverse effects* / Q000627:therapeutic use; D004630:Emergencies; D057510:Endovascular Procedures; D007172:Erectile Dysfunction / Q000188:drug therapy; D006491:Hemothorax / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012769:Shock / Q000209:etiology; D015607:Stents; D000068581:Tadalafil; D014057:Tomography, X-Ray Computed
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil