title: Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei.
abstract: This study aimed to evaluate the in vitro combination of farnesol and β-lactams against Burkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P ≤ 0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains of B. pseudomallei.
authors.affiliation: Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza-CE, Brazil. brilhante@ufc.br
authors.forename: R S N
authors.initials: RS
authors.lastname: Brilhante
authors.forename: L G A
authors.initials: LG
authors.lastname: Valente
authors.forename: M F G
authors.initials: MF
authors.lastname: Rocha
authors.forename: T J P G
authors.initials: TJ
authors.lastname: Bandeira
authors.forename: R A
authors.initials: RA
authors.lastname: Cordeiro
authors.forename: R A C
authors.initials: RA
authors.lastname: Lima
authors.forename: J J G
authors.initials: JJ
authors.lastname: Leite
authors.forename: J F
authors.initials: JF
authors.lastname: Ribeiro
authors.forename: J F
authors.initials: JF
authors.lastname: Pereira
authors.forename: D S C M
authors.initials: DS
authors.lastname: Castelo-Branco
authors.forename: A J
authors.initials: AJ
authors.lastname: Monteiro
authors.forename: J J C
authors.initials: JJ
authors.lastname: Sidrim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000254:growth & development; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D005204:Farnesol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D005204:Farnesol; D001618:beta-Lactamases