title: Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China.
abstract: We report here a clinical and molecular study on a case suffer from severe fever with thrombocytopenia syndrome (SFTS) due to a new type of bunyavirus, named SFTS bunyavirus (SFTSV), in Zhejiang Province China. The key clinical features of this patient include fever, lymphocytopenia and thrombocytopenia. We carried out a serological and molecular investigation in the indicated case and on relatives with close contact. The SFTSV infection was confirmed through amplification of viral genetic material using the polymerase chain reaction (PCR) from the patient's serum, but not relatives with close contact. Subsequently direct sequence of PCR product demonstrated a homology of 94-96% in the nucleotide sequence compared to a reference sequence previously reported, in which the majority of patients originated from an epidemic area of Central and Northeast China. Our results suggest that SFTSV can occur in a non-epidemic area due to a similar strain of SFTSV that apparently affect the blood system, implying the importance of dissecting the pathogenesis of SFTS as well as mode of infection.
authors.affiliation: Department of Infectious Diseases, Zhoushan Hospital, Zhejiang, China.
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
authors.forename: Chuan
authors.initials: C
authors.lastname: Xue
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Fu
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.forename: Xianjun
authors.initials: X
authors.lastname: Ding
authors.forename: Ruiding
authors.initials: R
authors.lastname: Liu
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Lin
authors.forename: Nengming
authors.initials: N
authors.lastname: Chai
authors.forename: Xuchun
authors.initials: X
authors.lastname: Yang
authors.forename: Yekai
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuncheng
authors.initials: Y
authors.lastname: Li
authors.forename: Zheen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xunjia
authors.initials: X
authors.lastname: Cheng
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002044:Bunyaviridae Infections / Q000473:pathology*; D002681:China; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005334:Fever / Q000473:pathology* / Q000821:virology; D006801:Humans; D016851:Orthobunyavirus / Q000235:genetics*; D016133:Polymerase Chain Reaction; D013921:Thrombocytopenia / Q000473:pathology* / Q000821:virology
chemical_list: D017931:DNA Primers