title: Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis.
abstract: Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.
authors.affiliation: University of Arkansas for Medical Sciences and Central Arkansas Veterans Health System, Little Rock, AR, USA, tanusingla@yahoo.co.in.
authors.forename: Tanu
authors.initials: T
authors.lastname: Goyal
authors.forename: Sona
authors.initials: S
authors.lastname: Mitra
authors.forename: Magomed
authors.initials: M
authors.lastname: Khaidakov
authors.forename: Xianwei
authors.initials: X
authors.lastname: Wang
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singla
authors.forename: Zufeng
authors.initials: Z
authors.lastname: Ding
authors.forename: Shijie
authors.initials: S
authors.lastname: Liu
authors.forename: Jawahar L
authors.initials: JL
authors.lastname: Mehta