title: [Synthesis and characterization of some new rutin and 7-aminocephalosporanic acid derivatives].
abstract: Many studies show that flavonoids have a numerous biological properties, antimicrobial effects included. It is also known that rutin is able to increase the antibacterial activity of other compounds.
  
  
  METHODS
  Starting from these facts, we synthesised some water soluble rutin derivatives treating rutin with 1, 3-dichloro-2-propanol, 1-bromo-3-chloro-propane, 2-dibromethane, and dibrommethane, and than with 7-amino-cephalosporanic acid. The antimicrobial activity of the new compounds was determined by disc diffusion method.
  
  
  RESULTS
  Molecular formula, weight, yield, melting points and solubility of the new derivatives have been determined. Elemental analysis and spectral analysis (UV and IR) confirmed the structure of new compounds. CONCLUSIONS. These derivatives are water-soluble and have a good antimicrobial activity, both on Gram-positive and Gram-negative bacteria, comparable with that of tetracycline.
authors.affiliation: Disciplina de Chimie farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi.
authors.forename: D
authors.initials: D
authors.lastname: Lupaşcu
authors.forename: Cristina
authors.initials: C
authors.lastname: Tuchiluş
authors.forename: Maria
authors.initials: M
authors.lastname: Sutu
authors.forename: Alexandra
authors.initials: A
authors.lastname: Neagu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D012431:Rutin / Q000138:chemical synthesis*; D013057:Spectrum Analysis; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D003432:Cross-Linking Reagents; D006846:Hydrocarbons, Halogenated; C033489:1,3-dichloro-2-propanol; D012431:Rutin; D000517:alpha-Chlorohydrin; C030735:7-aminocephalosporanic acid; C560814:1-bromo-3-chloropropane; D011407:Propane