title: GC-MS and GC-IRD studies on dimethoxyphenethylamines (DMPEA): regioisomers related to 2,5-DMPEA.
abstract: A series of regioisomeric dimethoxyphenethylamines have a mass spectra essentially equivalent to the drug substance 2,5-dimethoxyphenethylamine (2,5-DMPEA). These substances have a molecular weight of 181, and major fragment ions in their electron ionization mass spectra at m/z 151/152. The trifluoroacetyl, pentafluoropropionyl, and heptafluorobutryl derivatives of these primary amines were prepared and evaluated by gas chromatography with mass spectrometry detection (GC-MS). The mass spectra for these derivatives do not show unique fragment ions to allow the specific identification of a particular isomer. Thus, GC-MS does not provide for the confirmation of identity of any one of the six isomers to the exclusion of the other five compounds. However, GC-MS does divide the compounds into two groups depending on the mass of the base peak. GC with infrared detection provides direct confirmatory data for the identification of 2,5-DMPEA from the other regioisomers involved in the study. Perfluoroacylated derivatives of the six regioisomeric dimethoxyphenethylamines were successfully resolved via capillary GC on a non-polar stationary phase consisting of 50% phenyl and 50% methyl polysiloxane (Rxi-50).
authors.affiliation: Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
authors.forename: Hadir M
authors.initials: HM
authors.lastname: Maher
authors.forename: Tamer
authors.initials: T
authors.lastname: Awad
authors.forename: Jack
authors.initials: J
authors.lastname: DeRuiter
authors.forename: C Randall
authors.initials: CR
authors.lastname: Clark
mesh_terms: D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008970:Molecular Weight; D013055:Spectrophotometry, Infrared / Q000379:methods; D013237:Stereoisomerism
chemical_list: D004118:Dimethoxyphenylethylamine