title: Incorporation of anti-inflammatory agent into calcium hydroxide pulp capping material: an in vitro study of physical and mechanical properties.
abstract: The aims of this study were to investigate the release of fluocinolone acetonide from an experimental pulp capping material containing fluocinolone acetonide (PCFA) and compare some physical and mechanical properties with Dycal(®). The PCFA is a hard-setting calcium hydroxide cement composed of 50 mmol/L fluocinolone acetonide. Conditioned media from the setting material was collected for determination of fluocinolone acetonide release by high performance liquid chromatography and pH measurement by pH meter. The setting time, compressive strength, disintegration, and acid soluble arsenic content were measured according to ISO 3107:2004. Dycal(®) was used as control. Fluocinolone acetonide could release at a range of suitable concentrations from PCFA. The pH, setting time, and acid soluble arsenic content of PCFA were significantly higher than those of Dycal(®). The compressive strength and disintegration of PCFA were comparable to control. PCFA may be considered as an alternative in pulp capping of inflamed dental pulp tissue.
authors.affiliation: Dental Biomaterials Science, Graduate School, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand.
authors.forename: Phumisak
authors.initials: P
authors.lastname: Louwakul
authors.forename: Veera
authors.initials: V
authors.lastname: Lertchirakarn
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry*; D001151:Arsenic / Q000737:chemistry; D002126:Calcium Hydroxide / Q000737:chemistry*; D055598:Chemical Phenomena; D002851:Chromatography, High Pressure Liquid; D017077:Culture Media, Conditioned; D004058:Diffusion; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000737:chemistry*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D055595:Mechanical Phenomena; D008903:Minerals / Q000737:chemistry; D057872:Pulp Capping and Pulpectomy Agents / Q000737:chemistry*; D012995:Solubility; D013314:Stress, Mechanical; D013696:Temperature; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D017077:Culture Media, Conditioned; D005938:Glucocorticoids; D008903:Minerals; D057872:Pulp Capping and Pulpectomy Agents; D005446:Fluocinolone Acetonide; C025702:Dycal; D001151:Arsenic; D002126:Calcium Hydroxide; D006851:Hydrochloric Acid