title: A review of the genetic background and tumour profiling in familial colorectal cancer.
abstract: Inherited predisposition plays a role in 10-30% of colorectal cancer (CRC) cases. Of the large families with a clearly positive family history of CRC, ∼40% is not affected by known CRC syndromes. The existence of families with unexplained forms of inherited CRC--familial CRC--suggests the presence of still unknown high- or moderate-risk CRC predisposing factors. While the genomic profiles of sporadic CRCs have been studied extensively, few studies have analysed the tumour profiles of hereditary or familial CRC. Here, we review recent advances in genomic tumour profiling in familial CRC in comparison with sporadic CRC. In addition, we discuss the role of known CRC risk factors in familial CRC.
authors.affiliation: Department of Pathology, LUMC, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. t.van_wezel@lumc.nl
authors.forename: Tom
authors.initials: T
authors.lastname: van Wezel
authors.forename: Anneke
authors.initials: A
authors.lastname: Middeldorp
authors.forename: Juul T
authors.initials: JT
authors.lastname: Wijnen
authors.forename: Hans
authors.initials: H
authors.lastname: Morreau
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins