title: Cross-coupling of non-activated chloroalkanes with aryl Grignard reagents in the presence of iron/N-heterocyclic carbene catalysts.
abstract: An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross-coupling conditions.
authors.affiliation: International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
authors.forename: Sujit K
authors.initials: SK
authors.lastname: Ghorai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Jin
authors.forename: Takuji
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D006571:Heterocyclic Compounds; C030011:carbene; D007501:Iron; D008697:Methane