title: Isostreptazolin and sannaphenol, two new metabolites from Streptomyces sannanensis.
abstract: Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 mM.
authors.affiliation: Ministry of Health Key Laboratory of Congenital Malformation, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Rong
authors.forename: Qiao
authors.initials: Q
authors.lastname: Leng
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D010636:Phenols; D010880:Piperidines; C428165:streptazolin