title: Acquired hemophilia associated with bullous pemphigoid: a case report.
abstract: The development of factor VIII inhibitors in non-hemophilic patients is rare and may occur in healthy individuals, mostly elderly and women in postpartum period, and in patients with malignant neoplasia or autoimmune diseases, such as bullous pemphigoid. We described the case of a 60-year-old female patient who developed bullous pemphigoid for 3 month and presented with bleeding tendency and hematoma in the tongue. Therapy with methylprednisolone, cyclophosphamide, intravenous immunoglobulin and factor VIII reposition was instituted, resulting in a remission of the bleeding and negativity for antibodies against factor VIII titers. We concluded that, despite its rarity, the presence of acquired factor VIII inhibitors should be investigated when patients with autoimmune diseases develop bleeding manifestations.
authors.affiliation: Department of Dermatology, Second Xiangya Hospital Central South University, No. 139, Renmin Road, Changsha, Hunan 410011, PR China.
authors.forename: Xiangning
authors.initials: X
authors.lastname: Qiu
authors.forename: Guiying
authors.initials: G
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Xiao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ganqun
authors.initials: G
authors.lastname: Li
authors.forename: Kailin
authors.initials: K
authors.lastname: Yan
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003029:Coagulants / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D017707:Erythrocyte Transfusion; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D005455:Fluorescent Antibody Technique; D006467:Hemophilia A / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D010949:Plasma
chemical_list: D000893:Anti-Inflammatory Agents; D003029:Coagulants; D016756:Immunoglobulins, Intravenous; D003520:Cyclophosphamide; D005169:Factor VIII; D008775:Methylprednisolone