title: Potential variant of multiple endocrine neoplasia in a dog.
abstract: This report describes multiple endocrine neoplasia in a dog, which is a rare hereditary disorder characterized by the presence of two or more neoplasms of different endocrine tissues within a patient. A 14 yr old dog was evaluated for polyuria/polydipsia, polyphagia, and abdominal enlargement. Adrenal-dependent hyperadrenocorticism with concomitant left thyroid enlargement and a presumed abdominal metastatic lesion were diagnosed by an adrenocorticotropic hormone stimulation test, ultrasonography, and computed tomography. Trilostane therapy was initiated and resolved the clinical signs for 2 yr at which time the dog presented with left testicular enlargement. The dog was euthanized and was diagnosed with adrenocortical carcinoma, thyroid carcinoma, an abdominal mass compatible with a metastatic lymph node, and bilateral interstitial cell testicular adenomas. To the authors' knowledge, this is the first report to describe the concomitant association of these types of endocrine neoplasms in a dog. The concomitant presence of these neoplasms could represent a potential variant of multiple endocrine neoplasia; however, the presence of the interstitial cell testicular adenomas may have only been an incidental finding. If any of these tumors are diagnosed, veterinarians should perform a thorough clinical assessment to evaluate for the presence of additional endocrine neoplasms or hyperplasia.
authors.affiliation: Dipartimento di Scienze Cliniche Veterinarie, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Proverbio
authors.forename: Eva
authors.initials: E
authors.lastname: Spada
authors.forename: Roberta
authors.initials: R
authors.lastname: Perego
authors.forename: Valeria
authors.initials: V
authors.lastname: Grieco
authors.forename: Matteo
authors.initials: M
authors.lastname: Lodi
authors.forename: Mauro
authors.initials: M
authors.lastname: Di Giancamillo
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ferro
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000473:pathology / Q000662:veterinary; D000308:Adrenocortical Hyperfunction / Q000473:pathology / Q000662:veterinary; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D008207:Lymphatic Metastasis; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000473:pathology / Q000662:veterinary*; D013964:Thyroid Neoplasms / Q000473:pathology / Q000662:veterinary