title: Quorum sensing in plaque biofilms: challenges and future prospects.
abstract: OBJECTIVE
  This review intends to provide a brief overview regarding quorum sensing among bacteria in biofilms and also attempts to throw light on the new research focusing on interference with the quorum sensing.
  
  
  BACKGROUND
  Dental plaque is an example of microbial biofilm leading to periodontal disease and dental caries. Quorum sensing is widely employed by a variety of gram-positive and gram-negative bacterial species to coordinate various activities in biofilms. Quorum-sensing-interfering compounds have either a positive or a negative effect on the expression of bacterial phenotypes regulated by quorum sensing. These studies of bacterial quorum sensing have also suggested several ideal targets for drug design which can be promising in preventive and therapeutic aspects of periodontal diseases and dental caries.
  
  
  RESULTS
  Studies have shown that periodontal disease and dental caries is caused by plaque biofilm bacteria. Quorum sensing is the means of communication between these bacteria to regulate a wide range of behavior patterns among them. The in vitro studies reviewed here have a vital role in opening up this field, because they reveal the basic machinery of cell--cell signaling in microbial communities. The signal machinery bacteria use to coordinate a variety of their activities is identified by these studies. Further, this review aims to discuss several natural and synthetic methods which were used for manipulating bacterial quorum sensing.
  
  
  CONCLUSIONS
  The future challenge lies in the ability of the dental research to develop additional mechanisms for interfering with bacterial quorum sensing which can be used as preventive and therapeutic tools for combating oral polymicrobial diseases.
  
  
  CONCLUSIONS
  This article aims at reviewing the literature and helping us to understand the ways of communication among bacteria in biofilms, which further open up the prospects in the treatment of diseases caused by biofilms.
authors.affiliation: Department of Prosthodontics, Indira Gandhi Institute of Dental Sciences, Puducherry, India. impressioncare@gmail.com
authors.forename: Baswaraj
authors.initials: B
authors.lastname: Biradar
authors.forename: Prapulla
authors.initials: P
authors.lastname: Devi
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000502:physiology; D018441:Biofilms / Q000187:drug effects; D061269:DNA Transformation Competence / Q000502:physiology; D003773:Dental Plaque / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000502:physiology; D006094:Gram-Positive Bacteria / Q000502:physiology; D006801:Humans; D010641:Phenotype; D053038:Quorum Sensing / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins