title: Anticancer effects of Huaier are associated with down-regulation of P53.
abstract: This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Ling
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xie
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Shusen
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004052:Diethylnitrosamine; D015536:Down-Regulation / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008516:Medicine, Chinese Traditional; D012333:RNA, Messenger / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C483800:Afp protein, rat; D000972:Antineoplastic Agents, Phytogenic; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53; D000509:alpha-Fetoproteins; D004052:Diethylnitrosamine; D000410:Alanine Transaminase