title: Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report.
abstract: BACKGROUND
  Chondrosarcoma is well-known to be primarily resistant to conventional radiation and chemotherapy.
  
  
  METHODS
  We present the case of a 32-year-old Caucasian man with clear cell chondrosarcoma who presented with symptomatic recurrence in his pelvis and metastases to his skull and lungs. Our patient underwent systemic therapy with sunitinib and then consolidation with proton beam radiation to his symptomatic site. He achieved complete symptomatic relief with a significantly improved performance status and had an almost complete and durable metabolic response on fluorine-18-fluorodeoxyglucose positron emission tomography.
  
  
  CONCLUSIONS
  Our findings have important clinical implications and suggest novel clinical trials for this difficult to treat disease.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida Shands Cancer Center, University of Florida, Gainesville, FL, USA. long.dang@medicine.ufl.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Dallas
authors.forename: Iman
authors.initials: I
authors.lastname: Imanirad
authors.forename: Rajiv
authors.initials: R
authors.lastname: Rajani
authors.forename: Roi
authors.initials: R
authors.lastname: Dagan
authors.forename: Sukanthini
authors.initials: S
authors.lastname: Subbiah
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gaa
authors.forename: Wayne A
authors.initials: WA
authors.lastname: Dwarica
authors.forename: Alison M
authors.initials: AM
authors.lastname: Ivey
authors.forename: Robert A
authors.initials: RA
authors.lastname: Zlotecki
authors.forename: Robert
authors.initials: R
authors.lastname: Malyapa
authors.forename: Danny J
authors.initials: DJ
authors.lastname: Indelicato
authors.forename: Mark T
authors.initials: MT
authors.lastname: Scarborough
authors.forename: John D
authors.initials: JD
authors.lastname: Reith
authors.forename: C Parker
authors.initials: CP
authors.lastname: Gibbs
authors.forename: Long H
authors.initials: LH
authors.lastname: Dang