title: [The clinical pathophysiology of the early metabolic syndrome: pathogenetic roles of juvenile dyspituitarism, connective tissue dysplasiae and autoimmune thyroiditis].
abstract: A review of world literature, including authors' original papers, establishes the clinical pathophysiological hypothesis, initially coined in by authors in 2002, about regular transition of adolescent hypothalamic syndrome (obesity with rose striae) with age into early metabolic syndrome, complicated by autoimmune thyroiditis. Some evidences are obtained, that witness for marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition (6 fig., 3 tables, bibl.: 92 ref.).
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Stroev
authors.forename: L P
authors.initials: LP
authors.lastname: Churilov
authors.forename: M M
authors.initials: MM
authors.lastname: Agapov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kononova
authors.forename: O M
authors.initials: OM
authors.lastname: Mudzukova
authors.forename: S A
authors.initials: SA
authors.lastname: Sadov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Serdiuk
mesh_terms: D000293:Adolescent; D003240:Connective Tissue Diseases / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000473:pathology / Q000503:physiopathology; D010900:Pituitary Diseases / Q000473:pathology / Q000503:physiopathology; D013967:Thyroiditis, Autoimmune / Q000473:pathology / Q000503:physiopathology