title: Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?
abstract: The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms. Sixty premenopausal women diagnosed with fibromyalgia according to the ACR criteria and 20 healthy women whose age and weight matched the premenopausal women were evaluated. Pain intensity, pain threshold, the number of tender points, the tender point index, the fibromyalgia impact questionnaire (FIQ), the Beck depression and Beck anxiety scores and patient symptoms were evaluated in all the women. Serum and erythrocyte magnesium levels were also measured. The patients were divided into three groups. The magnesium citrate (300 mg/day) was given to the first group (n = 20), amitriptyline (10 mg/day) was given to the second group (n = 20), and magnesium citrate (300 mg/day) + amitriptyline (10 mg/day) treatment was given to the third group (n = 20). All parameters were reevaluated after the 8 weeks of treatment. The serum and erythrocyte magnesium levels were significantly lower in patients with fibromyalgia than in the controls. Also there was a negative correlation between the magnesium levels and fibromyalgia symptoms. The number of tender points, tender point index, FIQ and Beck depression scores decreased significantly with the magnesium citrate treatment. The combined amitriptyline + magnesium citrate treatment proved effective on all parameters except numbness. Low magnesium levels in the erythrocyte might be an etiologic factor on fibromyalgia symptoms. The magnesium citrate treatment was only effective tender points and the intensity of fibromyalgia. However, it was effective on all parameters when used in combination with amitriptyline.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Acıbadem University Medical School, Istanbul, Turkey. seldabagis@hotmail.com
authors.forename: Selda
authors.initials: S
authors.lastname: Bagis
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karabiber
authors.forename: Ismet
authors.initials: I
authors.lastname: As
authors.forename: Lülüfer
authors.initials: L
authors.lastname: Tamer
authors.forename: Canan
authors.initials: C
authors.lastname: Erdogan
authors.forename: Ayçe
authors.initials: A
authors.lastname: Atalay
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use; D000700:Analgesics / Q000097:blood / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D002400:Cathartics / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D019343:Citric Acid / Q000097:blood / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009942:Organometallic Compounds / Q000097:blood / Q000627:therapeutic use*; D010045:Outpatients; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D017697:Premenopause; D020127:Recovery of Function; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D002400:Cathartics; D009942:Organometallic Compounds; D000639:Amitriptyline; D019343:Citric Acid; C110422:magnesium citrate