title: Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.
abstract: The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
authors.affiliation: State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. cpneau@yahoo.cn
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Qiu-Gang
authors.initials: QG
authors.lastname: Ma
authors.forename: Cheng
authors.initials: C
authors.lastname: Ji
authors.forename: Jian-Yun
authors.initials: JY
authors.lastname: Zhang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yong-Ze
authors.initials: YZ
authors.lastname: Jie
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D019587:Dietary Supplements; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D008063:Thioctic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D008063:Thioctic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase