title: Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation.
abstract: Milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein secreted from various cells, enhances engulfment of apoptotic cells by forming a link between phosphatidylserine on apoptotic cells and α(v)β(3)-integrin on phagocytes. This process is essential for maintaining the host immune system under physiological conditions. Apart from this scavenging function, MFG-E8 also directly regulates a variety of cellular functions, such as attenuating inflammation and healing of injured tissues. Furthermore, recent studies have revealed that MFG-E8 has anti-inflammatory and regenerating roles during intestinal inflammation. This review highlights novel findings regarding the roles of MFG-E8 in intestinal pathophysiology as well as its therapeutic potential for gut inflammatory disorders.
authors.affiliation: Department of Internal Medicine II, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Japan.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Monowar
authors.initials: M
authors.lastname: Aziz
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oka
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tada
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D007422:Intestines / Q000503:physiopathology*; D051379:Mice; D008894:Milk Proteins
chemical_list: D000954:Antigens, Surface; C098942:MFGE8 protein, human; C490919:Mfge8 protein, mouse; D008894:Milk Proteins