title: Mortality prediction in the elderly by an easily measured metabolic index.
abstract: OBJECTIVE
  Hyperglycaemia enhances the risk of cardiovascular events and death, while high-density lipoprotein cholesterol (HDLc) is protective. Information on these associations among the elderly population is scanty. We applied a cardiometabolic risk index (CMRI) based on HDLc and fasting plasma glucose (FPG) in an elderly Swedish population.
  
  
  METHODS
  In total, 432 75-year-olds were followed for 10-year mortality. The impact of risk factors on survival was analysed using Cox regression.
  
  
  RESULTS
  HDLc (mmol/l; median and interquartile range) was 1.6 (1.3-2.0) in women and 1.4 (1.2-1.5) in men, while FPG was 5.9 (5.5-6.6) and 5.9 (5.5-6.5). Some 89 persons were at high risk according to CMRI, and 163 persons died. FPG was related to mortality in women (HR; 95% CI: 1.23; 1.10-1.37) and there was a similar trend in men (1.08; 1.00-1.17; p = 0.061). Increasing HDLc was protective in men (0.38; 0.19-0.77) but not in women (0.77; 0.45-1.29). CMRI was related to mortality in both genders even after adjustment for established risk factors (1.79; 1.14-2.79; p = 0.011).
  
  
  CONCLUSIONS
  The CMRI helps identify elderly subjects at risk and may serve as a cost-effective risk prediction tool.
authors.affiliation: Department of Medicine, Karolinska University Hospital, Stockholm, Sweden. laura.venskutonyte@ki.se
authors.forename: Laura
authors.initials: L
authors.lastname: Venskutonyte
authors.forename: Lars
authors.initials: L
authors.lastname: Rydén
authors.forename: Göran
authors.initials: G
authors.lastname: Nilsson
authors.forename: John
authors.initials: J
authors.lastname: Ohrvik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000401:mortality*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL