title: Dog EEG for wake-promotion studies.
abstract: Described in this unit is a protocol for investigating the wake-promoting activity of new chemical entities (NCEs) in dog. The experimental approach is based on scoring of sleep/wake stages in animals implanted with a telemetry device for recording EMG and cortical EEG signals. A major advantage of this procedure is that it is conducted in nontethered animals, limiting possible bias and complications encountered with conventional recording systems. In this procedure, polygraphic recording is conducted using four implanted beagles. Results of studies with modafinil, a wake-promoting agent, are described to demonstrate the utility of this test procedure.
authors.affiliation: Centre de Développement Cephalon France, Maisons Alfort, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Parmentier
authors.forename: Denis
authors.initials: D
authors.lastname: Bricout
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Brousseau
authors.forename: Thierry
authors.initials: T
authors.lastname: Giboulot
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006970:Disorders of Excessive Somnolence / Q000188:drug therapy*; D004285:Dogs; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects* / Q000295:instrumentation; D000077408:Modafinil; D017286:Polysomnography / Q000295:instrumentation / Q000379:methods; D013048:Specimen Handling / Q000379:methods; D013686:Telemetry / Q000295:instrumentation; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil