title: Primitive neuroectodermal tumor of the heart.
abstract: We present a case of primitive neuroectodermal tumor of the left atrium with involvement of the coronary sinus. The initial presentation was of cardiac tamponade resulting from the size of the tumor. There was no evidence of tumor elsewhere, and after complete resection and without adjuvant chemotherapy the patient is well at 2-year follow-up. There has been no evidence of tumor recurrence. This is a rare reported case of resection of a cardiac primitive neuroectodermal tumor without adjuvant chemotherapy. Other cases in the literature have been treated by orthoptic transplantation and resection with chemotherapy.
authors.affiliation: Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, United Kingdom.
authors.forename: Nnamdi
authors.initials: N
authors.lastname: Nwaejike
authors.forename: Doris
authors.initials: D
authors.lastname: Rassl
authors.forename: Hugo
authors.initials: H
authors.lastname: Ford
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Large
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002305:Cardiac Tamponade / Q000209:etiology*; D002585:Cesarean Section; D054326:Coronary Sinus / Q000473:pathology*; D004417:Dyspnea / Q000209:etiology; D004487:Edema / Q000209:etiology; D005260:Female; D006325:Heart Atria / Q000473:pathology*; D006338:Heart Neoplasms / Q000737:chemistry / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D017599:Neuroectodermal Tumors / Q000737:chemistry / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010490:Pericardial Effusion / Q000209:etiology; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery; D051789:Proto-Oncogene Protein c-fli-1 / Q000235:genetics; D011644:Puerperal Disorders / Q000473:pathology* / Q000601:surgery; D034802:RNA-Binding Protein EWS / Q000235:genetics; D012074:Remission Induction
chemical_list: D014408:Biomarkers, Tumor; C106031:EWS-FLI fusion protein; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS