title: Colored petri nets to model gene mutation and amino acids classification.
abstract: The genetic code is the triplet code based on the three-letter codons, which determines the specific amino acid sequences in proteins synthesis. Choosing an appropriate model for processing these codons is a useful method to study genetic processes in Molecular Biology. As an effective modeling tool of discrete event dynamic systems (DEDS), colored petri net (CPN) has been used for modeling several biological systems, such as metabolic pathways and genetic regulatory networks. According to the genetic code table, CPN is employed to model the process of genetic information transmission. In this paper, we propose a CPN model of amino acids classification, and further present the improved CPN model. Based on the model mentioned above, we give another CPN model to classify the type of gene mutations via contrasting the bases of DNA strands and the codons of amino acids along the polypeptide chain. This model is helpful in determining whether a certain gene mutation will cause the changes of the structures and functions of protein molecules. The effectiveness and accuracy of the presented model are illustrated by the examples in this paper.
authors.affiliation: School of Control Science and Engineering, Shandong University, Jinan, Shandong Province 250061, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Gao
authors.forename: Max Q-H
authors.initials: MQ
authors.lastname: Meng
authors.forename: Tzyh-Jong
authors.initials: TJ
authors.lastname: Tarn
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000145:classification* / Q000235:genetics; D000818:Animals; D005815:Genetic Code; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*
chemical_list: D000596:Amino Acids