title: Superficial siderosis of the central nervous system: a rare cause of dementia with therapeutic consequences.
abstract: A 75-year-old patient was evaluated for dementia. His past medical history included an ischaemic cardiomyopathy treated with aspirin daily. His neurological examination showed mild ataxia syndrome and central deafness. The neuropsychological examination did not suggest Alzheimer's disease. No specific aetiology was found from biological investigations, but MRI scans revealed a superficial siderosis, which was further confirmed with CSF exams. This case highlights the interest of MRI with echo-gradient-T2 weighted sequences in patients investigated for memory disorders. Once the diagnosis is known, specific preventive measures have to be taken: searching for a treatable source of bleeding and the interruption of antiplatelet aggregation or anticoagulant treatments.
authors.affiliation: Department of Neurology,  CHU Avicenne AP-HP-Paris, 125 route de Stalingrad, Bobigny,  France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Dubessy
authors.forename: Renata
authors.initials: R
authors.lastname: Ursu
authors.forename: Didier
authors.initials: D
authors.lastname: Maillet
authors.forename: Alexandre
authors.initials: A
authors.lastname: Augier
authors.forename: Johan
authors.initials: J
authors.lastname: Le Guilloux
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Carpentier
authors.forename: Catherine
authors.initials: C
authors.lastname: Belin
mesh_terms: D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D003704:Dementia / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology / Q000628:therapy; D006486:Hemosiderosis / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin