title: [Molecularly imprinted hydrophilic polymer sorbents for selective sorption of erythromycin].
abstract: New hydrophilic polymer sorbents comprising reactionary sites which are complementary to a molecule of antibiotic erythromycin were synthesized by the method of molecular imprinting. A series of similar sorbents without reactionary sites was used for comparison of sorption characteristics. Sorption of erythromycin on both types of polymer sorbents synthesized was studied in a wide range of pH and ionic strength. Selectivity of erythromycin sorption on molecularly imprinted cross-linked polymers was shown to depend on the specific interaction of target molecule with polymer matrix. This type of sorbent is perspective for the development of antibiotic purification directly from a culture medium Saccharopolyspora erythreus.
authors.forename: N M
authors.initials: NM
authors.lastname: Ezhova
authors.forename: I S
authors.initials: IS
authors.lastname: Garkushina
authors.forename: O A
authors.initials: OA
authors.lastname: Pisarev
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004917:Erythromycin / Q000096:biosynthesis / Q000302:isolation & purification*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007218:Industrial Microbiology / Q000379:methods*; D007477:Ions; D008768:Methylmethacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism; D016930:Saccharopolyspora / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D007477:Ions; D008768:Methylmethacrylates; D011108:Polymers; C021302:hydroxymethylmethacrylate; D004917:Erythromycin