title: [Hematologic and immunologic signs of lupus: the experience of the hospital of Dakar].
abstract: BACKGROUND
  The systemic erythematosus lupus (SEL) or lupic disease is a systemic auto-immune pathology, characterized primarily by the presence of antibodies directed against native antibodies anti-DNA. The circumstances of discovery are variable and polymorphic. The hematologic signs and the immunological disorders constitute criteria of diagnosis of lupic disease.
  
  
  METHODS
  It is a multicentric retrospective study from January 1, 1997 to September 30, 2006. Patients were followed up in Internal medicine of Dakar. We appreciate the hematologic and immunological aspects appreciate their prognosis prevalence and their implications with the course the lupic disease.
  
  
  RESULTS
  142 lupic patients were included with 125 women and 17 men; the sex ratio is 0.13. The average age was 34 years with extremes of 6 and 72 years. Our patients had hematologic manifestations average in 32,4 % of the cases and immunological in 76,8 % of the cases. The immunological tests showed the presence, of antinuclear antibodies in 97,9 % of the cases, of native antibody anti-DNA in 45,7 % of the cases, the anti-ECT in 86,95 % (with the anti-RNP in 78,3 % of the cases, anti-Sm in 56,5 % and of anti-SSA in 87 % of the cases). Antibodies anti-DNA and anti-ECT were associated with the hematologic demonstrations respectively in 92,0 % and 95 % of the cases (p = 0,08). Total survival in 96 % of the cases is estimated to 7 years.
  
  
  CONCLUSIONS
  The circumstances of discovery of the lupic disease are variable. The hematologic signs constitute criteria diagnosis of lupic disease. The accessibility of the hematologic and immunological assessment is necessary for an early diagnosis and an early treatment.
authors.affiliation: Service de Médecine Interne CHU Le Dantec BP 10599 Dakar Sénégal. fatou.sene1@caramail.com
authors.forename: Fatou Samba Diango
authors.initials: FS
authors.lastname: Ndiaye
authors.forename: M M
authors.initials: MM
authors.lastname: Ka
authors.forename: Seynabou
authors.initials: S
authors.lastname: Fall
authors.forename: Awa
authors.initials: A
authors.lastname: Dioum
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Pouye
authors.forename: Thérèse
authors.initials: T
authors.lastname: Moreira-Diop
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology; D000974:Antibodies, Antinuclear / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012675:Senegal; D013921:Thrombocytopenia / Q000209:etiology; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA