title: MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
abstract: The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
authors.affiliation: Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Masuda
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Nakamura
authors.forename: Nozomu
authors.initials: N
authors.lastname: Takata
authors.forename: Bunsho
authors.initials: B
authors.lastname: Itoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirose
authors.forename: Hiroki
authors.initials: H
authors.lastname: Moribe
authors.forename: Eisuke
authors.initials: E
authors.lastname: Mekada
authors.forename: Masato
authors.initials: M
authors.lastname: Okada
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010641:Phenotype; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D015398:Signal Transduction / Q000502:physiology
chemical_list: D029742:Caenorhabditis elegans Proteins; C120452:MIG-13 protein, Caenorhabditis elegans; D008565:Membrane Proteins; D011494:Protein Kinases; C471235:SRC-1 protein, C elegans; C104620:UNC-71 protein, C elegans; D008666:Metalloendopeptidases