title: Developing a new experimental model of abdominal compartment syndrome.
abstract: OBJECTIVE
  To describe an experimental, unprecedented model that mimics the abdominal compartment syndrome (ACS).
  
  
  METHODS
  twenty rats were randomly divided into four groups. To simulate ACS intra-abdominal hypertension (IAH) was induced by inserting cotton surgical dressing (Zobec ®), 15x15cm (intra-abdominal pressure constant and equal to 12 mmHg) associated with hypovolemia induced by withdrawing blood, keeping mean arterial pressure (MAP) around 60 mmHg (HYPO). To dissociate the effects of those IAH-induced hypovolemia per se, two other groups were analyzed: one with only with IAH and another with only hypovolemia. The simulation group (sham) underwent the same surgical procedure performed earlier, however, the levels of intra-abdominal pressure and MAP were kept in 3 mmHg and 90 mmHg, respectively.
  
  
  RESULTS
  By analyzing the impact of IAH on the small intestine, we observed necrosis of the villi, congestion, and neutrophilic infiltration. Hypovolemia induced only inflammation and edema of the villi. However, the association of IAH and HYPO led to hemorrhagic infarction, besides worsening of the aforementioned parameters.
  
  
  CONCLUSIONS
  This model was effective in inducing ACS expressed by the effects found in the small intestine.
authors.affiliation: Departamento de Cirurgia Geral, Faculdade de Medicina, Universidade Federal do Estado do Rio de Janeiro (UNI-RIO), Rio de Janeiro, RJ, Brazil. raclima@terra.com.br
authors.forename: Ricardo Antônio Correia
authors.initials: RA
authors.lastname: Lima
authors.forename: Alberto
authors.initials: A
authors.lastname: Schanaider
authors.forename: Maria Cristina Ebole
authors.initials: MC
authors.lastname: Santana
authors.forename: Mariana Genuíno
authors.initials: MG
authors.lastname: de Oliveira
authors.forename: Vera Luiza
authors.initials: VL
authors.lastname: Capelozzi
authors.forename: Patricia Rieken Macedo
authors.initials: PR
authors.lastname: Rocco
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D059325:Intra-Abdominal Hypertension; D008297:Male; D017208:Rats, Wistar