title: The first report of a patient with probable variant creutzfeldt-jakob disease in Turkey.
abstract: Variant Creutzfeldt-Jakob disease (vCJD) was first reported in the UK in 1996. Here, we report the first Turkish case of vCJD. A 47-year-old man, who has never lived outside of Turkey and had had no transfusion, was admitted to the University Hospital with speech disorder, cognitive decline and ataxia following depression, irritability, and personality change. The immunoassay of the 14-3-3 protein in the cerebrospinal fluid was negative. Brain magnetic resonance imaging revealed high-signal lesions involving the bilateral caudate and lentiform nucleus on T(2)- and diffusion-weighted imaging. The patient developed akinetic mutism 10 months after disease onset. The clinical presentation and neuroimaging findings were compatible with the vCJD cases reported since 1996 and met the World Health Organization's case definition for probable vCJD.
authors.affiliation: Department of Neurology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
authors.forename: Demet Özbabalık
authors.initials: DÖ
authors.lastname: Adapınar
authors.forename: Suzan
authors.initials: S
authors.lastname: Saylısoy
authors.forename: Cınar
authors.initials: C
authors.lastname: Yenilmez
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Aslan
authors.forename: Bengü
authors.initials: B
authors.lastname: Ertan
authors.forename: Sevilhan
authors.initials: S
authors.lastname: Artan
authors.forename: Gülcan
authors.initials: G
authors.lastname: Güleç
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Susuz
authors.forename: Baki
authors.initials: B
authors.lastname: Adapınar