title: Detection of intratumoral calcification in oligodendrogliomas by susceptibility-weighted MR imaging.
abstract: OBJECTIVE
  SWI is a unique pulse sequence sensitive to both hemorrhage and calcification. Our aim was to retrospectively assess the ability of SWI to detect intratumoral calcification in ODs compared with conventional MR imaging.
  
  
  METHODS
  Using CT as criterion standard, the MR imaging findings from 71 patients (33 males, 38 females; mean age, 42.5 years) with pathologically proved OD were retrospectively evaluated. We classified the MR imaging data into SWI data (MRSWI) and traditional pulse sequences (MRnoSWI). The sensitivity and specificity of the MRnoSWI (n = 71) were compared with that of the MRSWI (n = 13) independently and also for matched-paired data (n = 13). The Fisher exact test was applied to the matched-pair data for statistical evaluation.
  
  
  RESULTS
  For paired data of MRSWI and MRnoSWI (n = 13), there was significantly increased sensitivity of MRSWI (86%) for the detection of intratumoral calcification in OD compared with the MRnoSWI (14.3%) (P = .015, Fisher exact test) by using CT as the criterion standard. The overall accuracy of MRSWI for the paired data was also significantly greater (P = .048). The specificities were not significantly different (P = .773). The sensitivity of MRSWI (n = 13) was 86%, and for MRnoSWI (n = 71), it was 33.3%. Specificity of MRSWI was 83%, and for MRnoSWI, it was 95%.
  
  
  CONCLUSIONS
  SWI is better able to detect calcification in ODs than conventional MR imaging pulse sequences.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zulfiqar
authors.forename: N
authors.initials: N
authors.lastname: Dumrongpisutikul
authors.forename: J
authors.initials: J
authors.lastname: Intrapiromkul
authors.forename: D M
authors.initials: DM
authors.lastname: Yousem
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology*; D002114:Calcinosis / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000150:complications* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity