title: Human serum albumin conjugated biomolecules for cancer molecular imaging.
abstract: Molecular imaging is a fast growing field in biomedical research. The discovery, development and continual improvement of molecular probes are important for ongoing research efforts in molecular imaging. Human serum albumin (HSA) offers favorable characteristics and opportunities as a platform protein for molecular imaging probe discovery and optimization. It has many advantages, including alternation of biodistribution and pharmacokinetic properties of molecular imaging probes, enhancing the blood half-life of bio-molecules, and making these molecules multivalent, all of which make HSA a promising carrier for cancer-targeted imaging and therapy. Numerous studies have focused on the development and application of HSA-based cancer imaging and treatment. This review gives a brief account of albumin-based molecular probes, focusing on their applications in cancer molecular imaging, such as PET/SPECT, MRI and optical imaging.
authors.affiliation: Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA 94305, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.forename: Susan
authors.initials: S
authors.lastname: Hoppmann
authors.forename: Luxi
authors.initials: L
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D006207:Half-Life; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000737:chemistry / Q000493:pharmacokinetics; D009369:Neoplasms / Q000175:diagnosis; D012709:Serum Albumin / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D015335:Molecular Probes; D012709:Serum Albumin