title: Vibrio cholerae autoinducer CAI-1 interferes with Pseudomonas aeruginosa quorum sensing and inhibits its growth.
abstract: The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.
authors.forename: Hadas
authors.initials: H
authors.lastname: Ganin
authors.forename: Yael
authors.initials: Y
authors.lastname: Danin-Poleg
authors.forename: Yechezkel
authors.initials: Y
authors.lastname: Kashi
authors.forename: Michael M
authors.initials: MM
authors.lastname: Meijler
mesh_terms: D001426:Bacterial Proteins; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007659:Ketones / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D053038:Quorum Sensing / Q000187:drug effects*; D013045:Species Specificity; D014734:Vibrio cholerae / Q000737:chemistry*
chemical_list: C525620:3-hydroxytridecan-4-one; D001426:Bacterial Proteins; D007659:Ketones