title: [Impact of prenatal pyrethroid exposure on neurodevelopment of one-year old infants].
abstract: OBJECTIVE
  To investigate the impact of prenatal exposure to pyrethroid pesticides on neurodevelopment and behavior in a group of one-year old infants.
  
  
  METHODS
  Three metabolites of pyrethroids (cis-Cl2CA, trans-Cl2CA and 3-PBA) in urine samples of 301 pregnant women enrolled from somewhere of Jiangsu Province were detected, The anthropometrics and the neurodevelopment of their 1-year old infants were assessed using DST scales. The mothers were consent informed before the study.
  
  
  RESULTS
  Three metabolites of pyrethroid were detected in 95% of urine samples. The infants were divided into high, medium or low exposure group by the level of pyrethroid in their mothers' urine detected during pregnancy. The difference of neurodevelopment index (DQ) among three groups of one-year old children was significant (P < 0.05), and the association of pyrethroid exposure with neurodevelopment was verified by multiple liner regression analysis (beta = - 0.1453, P < 0.05).
  
  
  CONCLUSIONS
  Prenatal exposure to elevated levels of pyrethroid pesticides was associated with reduced neurodevelopment of infants in this population.
authors.affiliation: School of Public Health, Fudan University/Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai 200032, China. coin.hero@163.com
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Qi
authors.forename: Minglan
authors.initials: M
authors.lastname: Zheng
authors.forename: Chunhua
authors.initials: C
authors.lastname: Wu
authors.forename: Xiuli
authors.initials: X
authors.lastname: Chang
authors.forename: Guoquan
authors.initials: G
authors.lastname: Wang
authors.forename: Dasheng
authors.initials: D
authors.lastname: Lu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007223:Infant; D007306:Insecticides / Q000633:toxicity; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D009420:Nervous System / Q000254:growth & development*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011722:Pyrethrins / Q000378:metabolism / Q000633:toxicity* / Q000652:urine; D011795:Surveys and Questionnaires
chemical_list: D007306:Insecticides; D011722:Pyrethrins