title: A thermodynamical model for stress-fiber organization in contractile cells.
abstract: Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell's mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments.
authors.affiliation: Department of Civil, Environmental and Architectural Engineering, University of Colorado, Boulder, Colorado 80309-0428, USA.
authors.forename: Louis
authors.initials: L
authors.lastname: Foucard
authors.forename: Franck J
authors.initials: FJ
authors.lastname: Vernerey