title: [The metastatic process: history, models and recent advances].
abstract: The onset of metastasis is a critical event in the natural history of cancer, and is generally associated with a poor clinical outcome. Mechanistically, the metastatic process is made of several steps that are biologically distinct and now rather well characterized. Several explanatory models have been proposed: selective models (clonal selection), adaptive models (initial oncogenesis), involvement of tumor "stem" cells, epithelial-mesenchymal transition… The next progresses are expected to come from the characterization of circulating and disseminated tumor cells, which are two recently opened windows on the metastatic process in patients.
authors.affiliation: Département D'oncologie Médicale, Institut Curie, 26 rue d'Ulm, 75005 Paris, France. fcbidard@curie.fr
authors.forename: François-Clément
authors.initials: FC
authors.lastname: Bidard
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Poupon
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002999:Clone Cells / Q000473:pathology; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D019143:Evolution, Molecular; D005109:Extracellular Matrix / Q000473:pathology; D005544:Forecasting; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D009360:Neoplastic Cells, Circulating; D014411:Neoplastic Stem Cells / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D009363:Neoplasm Proteins