title: Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.
abstract: BACKGROUND
  Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.
  
  
  OBJECTIVE
  We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.
  
  
  METHODS
  A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.
  
  
  RESULTS
  After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.
  
  
  CONCLUSIONS
  The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.
authors.affiliation: Centre Hospitalier du Luxembourg - General Surgery. Goergen-m.martine@chl.lu
authors.forename: M
authors.initials: M
authors.lastname: Goergen
authors.forename: D
authors.initials: D
authors.lastname: Manzoni
authors.forename: V
authors.initials: V
authors.lastname: De Blasi
authors.forename: P
authors.initials: P
authors.lastname: Fabiano
authors.forename: V
authors.initials: V
authors.lastname: Poulain
authors.forename: L
authors.initials: L
authors.lastname: De Magistris
authors.forename: V
authors.initials: V
authors.lastname: Simonelli
authors.forename: K
authors.initials: K
authors.lastname: Dahan
authors.forename: J-S
authors.initials: JS
authors.lastname: Azagra
mesh_terms: D003920:Diabetes Mellitus / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000628:therapy; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D010535:Laparoscopy; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation; D009765:Obesity / Q000150:complications / Q000601:surgery*; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D015431:Weight Loss
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D044105:Receptor, Melanocortin, Type 4