title: Associations between organochlorine pesticides and vitamin D deficiency in the U.S. population.
abstract: BACKGROUND
  Recently low dose organochlorine (OC) pesticides have been strongly linked to various chronic diseases including diabetes and cardiovascular diseases. Both field and animal studies have suggested a possibility that persistent lipophilic chemicals like OC pesticides can cause vitamin D deficiency, but there have been no human studies of exposure to any chemical as a possible cause of vitamin D deficiency. This study was performed to examine if serum concentrations of OC pesticides were associated with serum concentrations of 25-hydroxyvitamin D (25(OH)D) in the U.S. general population.
  
  
  RESULTS
  Cross-sectional associations of serum OC pesticides with serum 25(OH)D were investigated in 1,275 subjects aged ≥20 in the National Health and Nutrition Examination Survey (NHANES), 2003-2004. We selected 7 OC pesticides detectable in ≥80% of participants. Among the 7 OC pesticides, p,p'-DDT (β = -0.022, P<0.01), p,p'-DDE (β = -0.018, P = 0.04), and β-hexachlorocyclohexane (β = -0.022, P = 0.02) showed significant inverse associations with serum 25(OH)D levels. When study subjects were stratified by age, race, and the presence of various chronic diseases, p,p'-DDT showed consistent inverse associations in all subgroups, although stronger associations tended to be observed among subjects with old age, white race, or chronic diseases.
  
  
  CONCLUSIONS
  The current study suggests that the background exposure to some OC pesticides leads to vitamin D deficiency in human. Considering the importance of vitamin D deficiency in the development of chronic diseases, chemical exposure as a possible cause of vitamin D deficiency should be evaluated in prospective and experimental studies.
authors.affiliation: Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
authors.forename: Jin-Hoon
authors.initials: JH
authors.lastname: Yang
authors.forename: Yu-Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Sang-Geun
authors.initials: SG
authors.lastname: Bae
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: Duk-Hee
authors.initials: DH
authors.lastname: Lee
mesh_terms: D000328:Adult; D003625:Data Collection; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010573:Pesticide Residues / Q000097:blood*; D012044:Regression Analysis; D014481:United States; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010573:Pesticide Residues; D014807:Vitamin D; C104450:25-hydroxyvitamin D