title: Clinical outcome after extended endovascular recanalization in Buerger's disease in 20 consecutive cases.
abstract: BACKGROUND
  To present our experience of extended endovascular management for thromboangiitis obliterans (Buerger's disease) patients with critical limb ischemia (CLI).
  
  
  METHODS
  Between January 2005 and July 2010, a consecutive series of 17 Buerger's disease patients with CLI in 20 limbs were admitted and the diagnosis confirmed. The mean age of the patients was 41.5 years (standard error: ±1.7). All patients presented with history of smoking, one patient presented with hypertension, and eight patients presented with dyslipidemia. According to Rutherford classification, all patients were found to be between grades 3 and 5. Ultrasonography first, and angiography examination later, confirmed a severe arterial disease involving almost exclusively below-the-knee and foot arteries in all cases. A new approach for revascularization, defined as extended angioplasty of each tibial and foot artery obstruction, was performed to achieve direct perfusion of at least one foot artery.
  
  
  RESULTS
  An extensive endovascular treatment was intended in all patients with success in 19 of 20 limbs, achieving a technical success in 95%. No mortality or complication related to the procedure was observed. During a mean follow-up of 23 months (standard error: ±4.05), amputation-free survival with no need of major amputation in any case and sustained clinical improvement was achieved in 16 of the 19 limbs (84.2%) successfully treated, resulting in a 100% limb salvage rate (19/19).
  
  
  CONCLUSIONS
  In this first experience, in patients with thromboangiitis obliterans, extended endovascular intervention was a feasible and effective revascularization procedure in case of CLI. High technical success, amputation-free survival, and sustained clinical improvement rates were achieved at midterm follow-up was achieved.
authors.affiliation: Invasive Cardiology Unit, Istituto Clinico Città di Brescia, Brescia, Italy. langrazi@tin.it
authors.forename: Lanfroi
authors.initials: L
authors.lastname: Graziani
authors.forename: Luis
authors.initials: L
authors.lastname: Morelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Parini
authors.forename: Laura
authors.initials: L
authors.lastname: Franceschini
authors.forename: PierFranco
authors.initials: P
authors.lastname: Spano
authors.forename: Stefano
authors.initials: S
authors.lastname: Calza
authors.forename: Sandra
authors.initials: S
authors.lastname: Sigala
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation; D016638:Critical Illness; D005240:Feasibility Studies; D005260:Female; D005528:Foot / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007558:Italy; D023821:Limb Salvage; D008297:Male; D012039:Regional Blood Flow; D012189:Retrospective Studies; D015607:Stents; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D015912:Thrombolytic Therapy; D016909:Tibial Arteries / Q000503:physiopathology*; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency