title: Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.
abstract: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber grown in the Indian subcontinent. This study evaluated the anti-nociceptive and anti-inflammatory effects of triterpenoid-enriched extract of T. dioica root (CETD) in rodents at the doses of 50 and 100 mg kg(-1) body weight po. Anti-nociceptive activity was evaluated by acetic acid-induced writhing and tail flick methods in Swiss albino mice. CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats. In writhing test, CETD dose dependently and significantly inhibited writhes; in tail flick test, CETD demonstrated significant increase in reaction time (after 60 and 120 min). In all the anti-inflammatory models, CETD exhibited promising anti-inflammatory activity in a dose-dependent manner. Therefore, T. dioica root afforded remarkable anti-nociceptive and anti-inflammatory protections in the tested rodent models.
authors.affiliation: Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly 712102, West Bengal, India. sakkwai@yahoo.com
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Pallab Kanti
authors.initials: PK
authors.lastname: Haldar
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006632:Histamine / Q000633:toxicity; D007194:India; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D012701:Serotonin / Q000633:toxicity; D029778:Trichosanthes / Q000737:chemistry*; D014315:Triterpenes / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan; D019342:Acetic Acid