title: PDCD1 polymorphisms are not associated with Takayasu's arteritis in Turkey.
abstract: OBJECTIVE
  Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Based on the associations of programmed death-1 (PD-1) protein encoding gene (PDCD1) with connective tissue diseases and vasculitides, PDCD1 polymorphisms are studied for susceptibility to TA in this study.
  
  
  METHODS
  The study group is made up of TA patients (n=229) fulfilling the 1990 ACR classification criteria and compared to 193 healthy controls (HC). PD-1.3, PD-1.5 and PD-1.6 single nucleotide polymorphisms of PDCD1 gene are genotyped by polymerase chain reaction and restriction analysis (PCR-RFLP).
  
  
  RESULTS
  The distribution of PD-1.5 polymorphism in TA patients and HC revealed a similar presence of TT genotype in patients and controls (13.3% vs. 11.4%). PD-1.3 and PD-1.6 were less polymorphic and did not differ between the groups. Rare AA genotype of PD-1.3 (1.4% vs. 1.0%) and AG genotype of PD-1.6 was again similarly (22.4% vs. 19.2%) present in TA and HC.
  
  
  CONCLUSIONS
  PD-1.3, 1.5 and 1.6 polymorphisms of PDCD1 gene, which were shown to be associated with various autoimmune disorders and vasculitides, are not associated with a susceptibility to TA in Turkish population.
authors.affiliation: Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. hanerdireskeneli@gmail.com
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
authors.forename: Ezgi
authors.initials: E
authors.lastname: Tuna-Erdoğan
authors.forename: Feyza
authors.initials: F
authors.lastname: Gündüz
authors.forename: Anna
authors.initials: A
authors.lastname: Bandurska-Luque
authors.forename: Büþra
authors.initials: B
authors.lastname: Alparslan
authors.forename: Maya
authors.initials: M
authors.lastname: Kebe
authors.forename: F Aytül
authors.initials: FA
authors.lastname: Uyar
authors.forename: Müge
authors.initials: M
authors.lastname: Bicakcigil
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.forename: Sevil
authors.initials: S
authors.lastname: Kamali
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ozbalkan
authors.forename: Askýn
authors.initials: A
authors.lastname: Ates
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Huseyin T E
authors.initials: HT
authors.lastname: Ozer
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
authors.forename: Fatos
authors.initials: F
authors.lastname: Önen
authors.forename: Emire
authors.initials: E
authors.lastname: Seyahi
authors.forename: Ahmet Mesut
authors.initials: AM
authors.lastname: Onat
authors.forename: Sibel Z
authors.initials: SZ
authors.lastname: Aydin
authors.forename: Neslihan
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Ayse
authors.initials: A
authors.lastname: Cefle
authors.forename: Veli
authors.initials: V
authors.lastname: Cobankara
authors.forename: Ercan
authors.initials: E
authors.lastname: Tunc
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Ozturk
authors.forename: Izzet
authors.initials: I
authors.lastname: Fresko
authors.forename: Yasar
authors.initials: Y
authors.lastname: Karaaslan
authors.forename: Nurullah
authors.initials: N
authors.lastname: Akkoc
authors.forename: A Eftal
authors.initials: AE
authors.lastname: Yücel
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
authors.forename: Gokhan
authors.initials: G
authors.lastname: Keser
authors.forename: Murat
authors.initials: M
authors.lastname: Inanc
authors.forename: Guher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D013625:Takayasu Arteritis / Q000453:epidemiology / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor