title: Paramagnetic dysprosium oxide nanoparticles and dysprosium hydroxide nanorods as T₂ MRI contrast agents.
abstract: We report here paramagnetic dysprosium nanomaterial-based T(2) MRI contrast agents. A large r(2) and a negligible r(1) is an ideal condition for T(2) MR imaging. At this condition, protons are strongly and nearly exclusively induced for T(2) MR imaging. The dysprosium nanomaterials fairly satisfy this because they are found to possess a decent r(2) but a negligible r(1) arising from L + S state 4f-electrons in Dy(III) ion ((6)H(15/2)). Their r(2) will also further increase with increasing applied field because of unsaturated magnetization at room temperature. Therefore, MR imaging and various physical properties of the synthesized d-glucuronic acid coated ultrasmall dysprosium oxide nanoparticles (d(avg) = 3.2 nm) and dysprosium hydroxide nanorods (20 × 300 nm) are investigated. These include hydrodynamic diameters, magnetic properties, MR relaxivities, cytotoxicities, and 3 tesla in vivo T(2) MR images. Here, MR imaging properties of dysprosium hydroxide nanorods have not been reported so far. These two samples show r(2)s of 65.04 and 181.57 s(-1)mM(-1), respectively, with negligible r(1)s at 1.5 tesla and at room temperature, no in vitro cytotoxicity up to 100 μM Dy, and clear negative contrast enhancements in 3 tesla in vivo T(2) MR images of a mouse liver, which will be even more improved at higher MR fields. Therefore, d-glucuronic acid coated ultrasmall dysprosium oxide nanoparticles with renal excretion can be a potential candidate as a sensitive T(2) MRI contrast agent at MR field greater than 3 tesla.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University, 1370, Sankyuk-dong, Buk-gu, Taegu 702-701, South Korea.
authors.forename: Krishna
authors.initials: K
authors.lastname: Kattel
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Park
authors.forename: Wenlong
authors.initials: W
authors.lastname: Xu
authors.forename: Han Gyeol
authors.initials: HG
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Badrul Alam
authors.initials: BA
authors.lastname: Bony
authors.forename: Woo Choul
authors.initials: WC
authors.lastname: Heo
authors.forename: Seonguk
authors.initials: S
authors.lastname: Jin
authors.forename: Jong Su
authors.initials: JS
authors.lastname: Baeck
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Tae Jeong
authors.initials: TJ
authors.lastname: Kim
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Bae
authors.forename: Kwon Seok
authors.initials: KS
authors.lastname: Chae
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D004419:Dysprosium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010087:Oxides / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D010087:Oxides; D004419:Dysprosium