title: Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis.
abstract: BACKGROUND
  To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme (ACE) confers susceptibility to vasculitis.
  
  
  METHODS
  A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis.
  
  
  RESULTS
  Twelve studies, including four on Behçet's disease (BD), four on Henoch-Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener's granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214-1.468, p = 7.4 × 10(-5)). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017-1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021-2.049, p = 0.038; OR 1.881, 95% CI 1.385-2.595, p = 6.6 × 10(-5)). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism.
  
  
  CONCLUSIONS
  This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seongbuk-gu, Seoul, Korea. lyhcgh@korea.ac.kr
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics; D016001:Confidence Intervals; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D011695:IgA Vasculitis / Q000235:genetics; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D014657:Vasculitis / Q000201:enzymology* / Q000235:genetics*
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A