title: Photostabilization of ascorbic acid with citric acid, tartaric acid and boric acid in cream formulations.
abstract: This study involves the evaluation of the effect of certain stabilizers, that is, citric acid (CT), tartaric acid (TA) and boric acid (BA) on the degradation of ascorbic acid (AH(2) ) in oil-in-water cream formulations exposed to the UV light and stored in the dark. The apparent first-order rate constants (0.34-0.95 × 10(-3) min(-1) in light, 0.38-1.24 × 10(-2) day(-1) in dark) for the degradation reactions in the presence of the stabilizers have been determined. These rate constants have been used to derive the second-order rate constants (0.26-1.45 × 10(-2) M(-1) min(-1) in light, 3.75-8.50 × 10(-3) M(-1) day(-1) in dark) for the interaction of AH(2) and the individual stabilizers. These stabilizers are effective in causing the inhibition of the rate of degradation of AH(2) both in the light and in the dark. The inhibitory effect of the stabilizers is in the order of CT > TA > BA. The rate of degradation of AH(2) in the presence of these stabilizers in the light is about 120 times higher than that in the dark. This could be explained on the basis of the deactivation of AH(2) -excited triplet state by CT and TA and by the inhibition of AH(2) degradation through complex formation with BA. AH(2) leads to the formation of dehydroascorbic acid (A) by chemical and photooxidation in cream formulations.
authors.affiliation: Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi-74600, Pakistan.
authors.forename: I
authors.initials: I
authors.lastname: Ahmad
authors.forename: M
authors.initials: M
authors.lastname: Ali Sheraz
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: Z
authors.initials: Z
authors.lastname: Shad
authors.forename: F H M
authors.initials: FH
authors.lastname: Vaid
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry*; D001888:Boric Acids / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013644:Tartrates / Q000737:chemistry*
chemical_list: D001888:Boric Acids; D013644:Tartrates; D019343:Citric Acid; D001205:Ascorbic Acid; C032688:boric acid; C029768:tartaric acid