title: Evaluation of the isokinetic muscle strength, balance and anaerobic performance in patients with young male hypogonadism.
abstract: Hypogonadism is a clinical condition that occurs due to infrequent abnormalities in the hypothalamic-pituitary-gonadal (HPG) axis in adolescence. Symptoms include weakening of muscle and bone strength. 30 young male patients with congenital hypogonadotropic hypogonadism (CHH) and 20 healthy young males were included in the present study. Quadriceps and hamstring muscle strength, balance and anaerobic performance capacities of the study group were measured both before and six months after Testosterone replacement therapy (TRT).  The strength of the extensor and flexor muscles of both legs showed a statistically significant increase in the isokinetic test values at 60(0)/sec and 180(0)/sec angular velocity (p < 0.05). When the parameters related to balance were investigated, a statistically significant difference was found for stability indices of left and right between pre-TRT and post-TRT (p = 0.001 for both comparisons). According to the patients' anaerobic performance measurement results, a statistically significant improvement (p < 0.001) was also found between pre-TRT and post-TRT values for each parameter. It was shown that TRT significantly increases muscle strength, balance, and anaerobic performance of patients with male CHH. As a result, we absolutely recommend the use of TRT in patients with male CHH.
authors.affiliation: Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey. uaydogan06@gmail.com
authors.forename: Umit
authors.initials: U
authors.lastname: Aydogan
authors.forename: Ali
authors.initials: A
authors.lastname: Eroglu
authors.forename: Halil
authors.initials: H
authors.lastname: Akbulut
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yildiz
authors.forename: Deniz Engin
authors.initials: DE
authors.lastname: Gok
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Taner
authors.initials: T
authors.lastname: Aydin
authors.forename: Erol
authors.initials: E
authors.lastname: Bolu
authors.forename: Kenan
authors.initials: K
authors.lastname: Saglam
mesh_terms: D000693:Anaerobiosis; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007866:Leg / Q000502:physiology; D008297:Male; D009068:Movement; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology; D011187:Posture / Q000502:physiology; D052097:Quadriceps Muscle / Q000502:physiology; D013739:Testosterone / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D013739:Testosterone