title: Role of liver X receptors in cholesterol efflux and inflammatory signaling (review).
abstract: Liver X receptors (LXRs) are nuclear receptors that play a central role             in cholesterol metabolism. When activated, LXRs induce a series of genes that             are involved in cholesterol efflux, absorption, transport and excretion. In recent             studies, LXRs have also been shown to play an important role in inflammatory signaling.             LXR agonists show promise as potential therapeutics, given their anti-atherogenic             and anti-inflammatory properties. The function of LXRs in cholesterol efflux and             inflammatory signaling make them attractive as therapies for cardiovascular and             inflammatory diseases.
authors.affiliation: Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Rongtao
authors.initials: R
authors.lastname: Zhu
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Ou
authors.forename: Xiongzhong
authors.initials: X
authors.lastname: Ruan
authors.forename: Jianping
authors.initials: J
authors.lastname: Gong
mesh_terms: D001053:Apolipoproteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D050155:Lipogenesis; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001053:Apolipoproteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D002784:Cholesterol