title: Identification of the primary outcomes that result from deficient spiral arterial modification in pregnant mice.
abstract: Pre-eclampsia, an acute complication of human pregnancy, is associated within complete physiological modification of decidual spiral arteries. This is thought to promote oxidative stress from perfusion/reperfusion of the placenta and to restrict placental and fetal growth. Alymphoid (genotype Rag2(-/-)/Il2rg(-/-)) mice, sufficient in dendritic and myeloid cell functions, lack spiral arterial modification with individual spiral arteries having ~1.7x the vascular resistance and 0.66x the blood velocity of +/+ mice. Their placentae are measurably hypoxic yet neither placental growth nor fetal survival is impaired and gestational hypertension is not seen. Thus, lymphocytes rather than vascular adaptations appear to be the pivotal contributors to the clinical complications of pre-eclampsia.
authors.affiliation: Department of Anatomy and Cell Biology, Queen's University, Kingston ON Canada K7L 3N6.
authors.forename: B Anne
authors.initials: BA
authors.lastname: Croy
authors.forename: Suzanne D
authors.initials: SD
authors.lastname: Burke
authors.forename: Valerie F
authors.initials: VF
authors.lastname: Barrette
authors.forename: Jianhong
authors.initials: J
authors.lastname: Zhang
authors.forename: Kota
authors.initials: K
authors.lastname: Hatta
authors.forename: Graeme N
authors.initials: GN
authors.lastname: Smith
authors.forename: Juares
authors.initials: J
authors.lastname: Bianco
authors.forename: Aureo T
authors.initials: AT
authors.lastname: Yamada
authors.forename: Michael A
authors.initials: MA
authors.lastname: Adams