title: Comparison of deterministic and stochastic simulation for capacity extension of high-purity water delivery systems.
abstract: This work presents a deterministic and a stochastic model for the simulation of industrial-size deionized water and water for injection (DI/WFI) systems. The objective of the simulations is to determine if additional DI/WFI demand from future production processes can be supported by an existing DI/WFI system. The models utilize discrete event simulation to compute the demand profile from the distribution system; they also use a continuous simulation to calculate the variation of the water level in the storage tank. Whereas the deterministic model ignores uncertainties, the stochastic model allows for both volume and schedule uncertainties. The Monte Carlo method is applied to solve the stochastic method. This paper compares the deterministic and stochastic models and shows that the deterministic model may be suitable for most applications and that the stochastic model should only be used if found necessary by the deterministic simulation. The models are programmed within Excel 2003 and are available for download as open public domain software (1), allowing for public modifications and improvements of the model. The proposed models may also be utilized to determine size or analyze the performance of other utilities, such as heat transfer media, drinking water, etc.
  Water for injection (WFI) and other pharmaceutical water distribution systems are notoriously difficult to analyze analytically due to the highly dynamic variable demand that is drawn from these systems. Discrete event simulation may provide an answer where the typical engineering approach of utilizing a diversity factor fails. This paper develops an Excel based deterministic and stochastic model for a WFI system with the latter allowing for the modeling of offtake volume and schedule uncertainty. The paper also compares the deterministic and stochastic models and shows that the deterministic model may be suitable for most applications while the stochastic model should only be used if found necessary. The models are available for download as open public domain software allowing for modifications and improvements of the model.
authors.affiliation: Department of Process and Chemical Engineering, University College Cork, Ireland.
authors.forename: Frank
authors.initials: F
authors.lastname: Riedewald
authors.forename: Edmond
authors.initials: E
authors.lastname: Byrne
authors.forename: Kevin
authors.initials: K
authors.lastname: Cronin
mesh_terms: D003198:Computer Simulation; D008954:Models, Biological; D009010:Monte Carlo Method; D012984:Software; D013269:Stochastic Processes; D014867:Water
chemical_list: D014867:Water