title: Connecting threads: epigenetics and metabolism.
abstract: Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable patterns of gene expression. The challenge will now be to understand how localized fluctuations in levels of metabolites control chromatin modifiers in space and time, translating a dynamic metabolic state into a histone map.
authors.affiliation: Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
authors.forename: Sayako
authors.initials: S
authors.lastname: Katada
authors.forename: Axel
authors.initials: A
authors.lastname: Imhof
authors.forename: Paolo
authors.initials: P
authors.lastname: Sassone-Corsi
mesh_terms: D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D056890:Eukaryota / Q000235:genetics* / Q000378:metabolism*; D042421:Histone Code; D006657:Histones / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D009243:NAD / Q000378:metabolism
chemical_list: D006657:Histones; D009243:NAD