title: Genotoxicity of ibuprofen in mouse bone marrow cells in vivo.
abstract: Genotoxicity of ibuprofen was evaluated by employing the mouse in vivo chromosomal aberration (CA) test. Ibuprofen administered orally at doses of 10, 20, 40, and 60 mg/kg body weight to mice resulted in mitotic depression and induction of CAs. A dose-related decrease in mitotic index (MI) and an increase in the frequencies of chromosomal aberrations per cell (CAs/cell) were recorded in bone marrow cells. However, a statistically significant reduction in MI and an increase in CAs/cell were found for both the higher doses. The results obtained indicate that ibuprofen is capable of inducing dose-dependent genotoxicity in bone marrow cells of mice.
authors.affiliation: Sarvajanik Pharmacy College, Gujarat, India.
authors.forename: Rina
authors.initials: R
authors.lastname: Tripathi
authors.forename: Shyam S
authors.initials: SS
authors.lastname: Pancholi
authors.forename: Pankaj
authors.initials: P
authors.lastname: Tripathi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D007052:Ibuprofen / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009153:Mutagens; D007052:Ibuprofen