title: [Biochemical mechanisms of chromium action in the human and animal organism].
abstract: Modern data concerning biologic characteristics of chromium (Cr3+) its placement in nature, accessibility and metabolic action of its different forms in humans and animals is presented in this survey. Essentiality of chromium for humans is emphasized, data about consumption norms of this microelement and its use for curing different diseases especially diabetes mellitus and atherosclerosis of vessels are presented. The biochemical mechanisms of Cr3+ effect on the metabolism in the human and animal organism are analyzed. It is shown that the organism reacts to chrome additions by the change of some metabolism links. Chrome influences positively growth and development of foetus, stimulates metabolism of glucose and insulin in the humans and animals. However, at the set chromium requirements it is necessary to take into account its low availability in food, high release of Cr3+ from the organism under the influence of stress factors, considerable decline of its level with age, and also in the period of pregnancy and lactation. Therefore experimental researches of introduction of Cr3+ additions to the diet of people and forage of animals taking into account their body mass, age and clinical state, can explain the biochemical mechanisms of biological action of this microelement.
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Iskra
authors.forename: V G
authors.initials: VG
authors.lastname: Ianovych
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology; D001823:Body Composition / Q000187:drug effects; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002857:Chromium / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology; D004032:Diet; D005260:Female; D005333:Fetus; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism*; D007774:Lactation / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D007328:Insulin; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; C485789:chromodulin protein, human; D002857:Chromium; D005947:Glucose