title: The effect of ketamine with remifentanil for improving the quality of anaesthesia and recovery in paediatric patients undergoing middle-ear ventilation tube insertion.
abstract: This prospective randomized study evaluated the effects of ketamine with remifentanil to improve the quality of anaesthesia and postoperative recovery, following brief procedures, in 60 paediatric patients undergoing middle-ear ventilation tube insertion (MEVTI). Patients were randomly  assigned to either ketamine 2 mg/kg intravenous [i.v.] bolus plus normal saline by i.v. infusion (K group, n = 30) or ketamine 2 mg/kg i.v. bolus, plus remifentanil 0.15 μg/kg per min i.v. infusion (KR group, n = 30). Parameters that were assessed included intraoperative patient  movement, surgeon satisfaction, anaesthesia time, total ketamine dose, postoperative recovery time, agitation and side-effects. Intraoperative patient movement scores were significantly lower, and surgeon satisfaction scores were significantly higher, in the KR group than in the K group. Time  to recovery was significantly shorter in the KR group than in the K group. In conclusion, remifentanil was a good adjuvant to ketamine, improving the quality of anaesthesia and postoperative recovery in children undergoing MEVTI.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Saint Vincent Hospital, The Catholic University of Korea, Suwon, Gyeonggi-do, Republic of Korea.
authors.forename: J-A
authors.initials: JA
authors.lastname: Lee
authors.forename: Y-S
authors.initials: YS
authors.lastname: Jeon
authors.forename: H-I
authors.initials: HI
authors.lastname: Noh
authors.forename: J-W
authors.initials: JW
authors.lastname: Choi
authors.forename: J-H
authors.initials: JH
authors.lastname: In
authors.forename: Y-M
authors.initials: YM
authors.lastname: Kim
authors.forename: J-D
authors.initials: JD
authors.lastname: Joo
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000592:standards*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D003710:Demography; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008876:Middle Ear Ventilation / Q000379:methods*; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011182:Postoperative Care; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D007649:Ketamine; D000077208:Remifentanil