title: Preliminary results of MRI-guided brachytherapy in cervical carcinoma: the Chiangmai University experience.
abstract: This study was performed to evaluate the feasibility of magnetic resonance imaging (MRI) in the treatment planning of image-guided brachytherapy for cervical carcinoma. Seventeen consecutive patients with locally advanced cervical cancer were enrolled in the study. Fifteen patients could be evaluated. When comparing the tumor at diagnosis (GTV-Dx) and the tumor at the first brachytherapy (GTV-BT), 11 of 15 patients showed a tumor regression of more than 80% while only four patients had less than 80% tumor regression. The mean D90 of HR-CTV and the calculated D2cc of the bladder, rectum, and sigmoid were 99.2 ± 11 Gy, 87.7 ± 5.7 Gy, 68.4 ± 5.4 Gy and 70.3 ± 6.8 Gy, respectively. No grade 3-4 acute toxicity was observed. The MRI can be a valuable tool for evaluating tumor response after external beam radiotherapy (EBRT) and is very helpful for prognosis prediction by residual GTV evaluation. Furthermore, MRI-guided brachytherapy allowed us to optimize the dose for both the target volumes and the OARs.
authors.affiliation: Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai University, Thailand. paan_31@hotmail.com
authors.forename: Ekkasit
authors.initials: E
authors.lastname: Tharavichitkul
authors.forename: Chate
authors.initials: C
authors.lastname: Sivasomboon
authors.forename: Somsak
authors.initials: S
authors.lastname: Wanwilairat
authors.forename: Vicharn
authors.initials: V
authors.lastname: Lorvidhaya
authors.forename: Vimol
authors.initials: V
authors.lastname: Sukthomya
authors.forename: Somvilai
authors.initials: S
authors.lastname: Chakrabhandu
authors.forename: Sanchai
authors.initials: S
authors.lastname: Lookkaew
authors.forename: Imjai
authors.initials: I
authors.lastname: Chitapanarux
authors.forename: Razvan
authors.initials: R
authors.lastname: Galalae
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D055815:Young Adult