title: Goblet cell hyperplasia and muscular layer thickening in the small intestine of a cynomolgus monkey.
abstract: We report here the interesting case of a 5-year-old male cynomolgus monkey with goblet cell hyperplasia and thickening of the muscular layer throughout the small intestine without exhibiting any clinical symptoms. Necropsy examination showed diffuse thickening of the intestinal wall from the jejunum to the ileum, with an appearance likened to a rubber tube. Histopathologically, marked thickening was observed in both the mucosal and muscular layers in the jejunum and ileum, and slight thickening was observed in the duodenum. Goblet cell hyperplasia with extension of the circular folds and villi was prominently observed. The mucosal surface was covered with a thick mucus layer containing desquamated mucosal epithelial cells, and both the inner and outer muscular layers were markedly thickened due to smooth muscle hypertrophy. Neither macroscopic nor histopathological examination identified any causative factors, such as infection, enteritis and intestinal stenosis, or obstruction that may have caused development of this lesion. Given these observations, this case may simply be considered of spontaneous goblet cell hyperplasia and muscular layer thickening in the small intestine of a cynomolgus monkey.
authors.affiliation: Toxicologic Pathology, Drug Safety Research Labs., Astellas Pharma Inc., 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Murakami
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Okayama
authors.forename: Shiro
authors.initials: S
authors.lastname: Fujihira
authors.forename: Takahisa
authors.initials: T
authors.lastname: Noto
authors.forename: Shunji
authors.initials: S
authors.lastname: Nakatsuji
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oishi