title: Lipoplatin treatment in lung and breast cancer.
abstract: The introduction of cisplatin in cancer treatment represents an important achievement in the oncologic field. Many types of cancers are now treated with this drug, and in testicular cancer patients major results are reached. Since 1965, other compounds were disovered and among them carboplatin and oxaliplatin are the main Cisplatin analogues showing similar clinical efficacy with a safer toxicity profile. Lipoplatin is a new liposomal cisplatin formulation which seems to have these characteristics. Lipoplatin was shown to be effective in NSCLC both in phase 2 and phase 3 trials, with the same response rate of Cisplatin, a comparable overall survival but less toxicity. A new protocol aiming to elucidate the double capacity of Lipoplatin to act as a chemotherapeutic and angiogenetic agent in triple-negative breast cancer patients is upcoming.
authors.affiliation: Department of Oncology and Oncohematology, Infermi Hospital, 2 Settembrini Street, 47900 Rimini, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Fantini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Gianni
authors.forename: Carlotta
authors.initials: C
authors.lastname: Santelmo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Drudi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Castellani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Affatato
authors.forename: Mario
authors.initials: M
authors.lastname: Nicolini
authors.forename: Alberto
authors.initials: A
authors.lastname: Ravaioli