title: Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China.
abstract: It has been reported that IDH1 (IDH1R132) mutation was a frequent genomic alteration in grade II and grade III glial tumors but rare in primary glioblastoma (pGBM). To elucidate the frequency of IDH1 mutation and its clinical significance in Chinese patients with pGBM, one hundred eighteen pGBMs were assessed by pyro-sequencing for IDH1 mutation status, and the results were correlated with clinical characteristics and molecular pathological factors. IDH1 mutations were detected in 19/118 pGBM cases (16.1%). Younger age, methylated MGMT promoter, high expression of mutant P53 protein, low expression of Ki-67 or EGFR protein were significantly correlated with IDH1 mutation status. Most notably, we identified pGBM cases with IDH1 mutation were mainly involved in the frontal lobe when compared with those with wild-type IDH1. In addition, Kaplan-Meier survival analysis revealed a highly significant association between IDH1 mutation and a better clinical outcome (p = 0.026 for progression-free survival; p = 0.029 for overall survival). However, in our further multivariable regression analysis, the independent prognostic effect of IDH1 mutation is limited when considering age, preoperative KPS score, extent of resection, TMZ chemotherapy, and Ki-67 protein expression levels, which might narrow its prognostic power in Chinese population in the future.
authors.affiliation: Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Gan
authors.initials: G
authors.lastname: You
authors.forename: Zhaoshi
authors.initials: Z
authors.lastname: Bao
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Liu
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000401:mortality; D002681:China; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005909:Glioblastoma / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000401:mortality; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000502:physiology; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human