title: Rhodium-catalyzed and zinc(II)-triflate-promoted asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones.
abstract: The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turnover frequency while suppressing epimerization of the products.
authors.affiliation: Chemical Product Research and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
authors.forename: Joel R
authors.initials: JR
authors.lastname: Calvin
authors.forename: Michael O
authors.initials: MO
authors.lastname: Frederick
authors.forename: Dana L T
authors.initials: DL
authors.lastname: Laird
authors.forename: Jacob R
authors.initials: JR
authors.lastname: Remacle
authors.forename: Scott A
authors.initials: SA
authors.lastname: May
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D008024:Ligands; D008698:Mesylates; D012238:Rhodium; C012077:trifluoromethanesulfonic acid