title: In vivo antihyperlipidemic activity of a new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides in rats.
abstract: A new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides (3a-3d and 4a'-4c') were synthesized. Compounds (3a, 3b, and 4a'-4c') were tested in vivo using Triton-WR-1339-induced hyperlipidemic rats as an experimental model for their hypolipidemic activity. The tested animals were divided into eight groups: control, hyperlipidemic, 3a, 3b, 4a', 4b', 4c', and bezafibrate. At a dose of 15 mg/kg, the elevated plasma triglyceride (TG) levels were significantly reduced in compounds 3b (p <0.0001) and 4c' (p <0.05) after 12 and 24 h compared to the normal control group. Furthermore, high-density lipoprotein-cholesterol levels were remarkably increased in compounds 3b (p <0.001) and 4c' (p <0.05). Meanwhile, compound 4b' slightly reduced the TG levels after 12 and 24 h. The present study demonstrated new properties of the novel series of benzofuran-2-carboxamides 3b and 4c' as potent lipid-lowering agents. It is, therefore, reasonable to assume that compounds 3b and 4c' may have a promising potential in the treatment of hyperlipidemia and coronary heart diseases.
authors.affiliation: Faculty of Pharmacy, Al-Zaytoonah University, Amman, Jordan. grah7781@yahoo.com
authors.forename: Tariq
authors.initials: T
authors.lastname: Al-Qirim
authors.forename: Ghassan
authors.initials: G
authors.lastname: Shattat
authors.forename: Kamal
authors.initials: K
authors.lastname: Sweidan
authors.forename: Waseem
authors.initials: W
authors.lastname: El-Huneidi
authors.forename: Ghassan
authors.initials: G
authors.lastname: Abu Sheikha
authors.forename: Reema
authors.initials: R
authors.lastname: Abu Khalaf
authors.forename: Suhair
authors.initials: S
authors.lastname: Hikmat
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D001629:Bezafibrate / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: D001572:Benzofurans; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D014280:Triglycerides; D011092:Polyethylene Glycols; C016811:tyloxapol; D001629:Bezafibrate