title: Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists.
abstract: The preferential 5-HT( 2)/5-HT(1C) receptor agonist DOI (0.1-4 mg/kg s.c.) caused an increase in locomotor activity, grooming and 'wet-dog' shakes (WDS) in the adult guinea-pig. The DOI-induced WDS behaviour was potently inhibited by several antagonists that have high affinity for the 5-HT(2) binding site. The WDS response is likely to be centrally-mediated since the effects of peripherally administered DOI were poorly antagonized by the peripherally-acting 5-HT(2) receptor antagonist BW501C67. Although these studies do not exclude an effect of DOI at 5-HT(1C) receptors, the high potency of ketanserin and spiperone in attenuating the effects of DOI would suggest an effect at the 5-HT(2) receptor. The present data suggest that antagonism of the directly-acting agonist DOI may be useful for assessing the selectivity and duration of action of centrally-acting 5-HT(2) receptor antagonists in the guinea-pig.
authors.affiliation: Department of Neuropharmacology, Glaxo Group Research Ltd, Park Road, Ware, Hertfordshire SG12 ODP, UK.
authors.forename: M
authors.initials: M
authors.lastname: Skingle
authors.forename: N
authors.initials: N
authors.lastname: Cole
authors.forename: G
authors.initials: G
authors.lastname: Higgins
authors.forename: W
authors.initials: W
authors.lastname: Feniuk