title: Hofmann-type rearrangement of imides by in situ generation of imide-hypervalent iodines(III) from iodoarenes.
abstract: The Hofmann-type rearrangement of aromatic and aliphatic imides using a hypervalent iodine(III) reagent generated in situ from PhI, m-CPBA, and TsOH·H(2)O proceeded in the presence of a base in alcohol to provide anthranilic acid derivatives and amino acid derivatives in high yields, respectively. This reaction proceeds through a tandem reaction via alcoholysis followed by a Hofmann rearrangement promoted by the formation of an imide-λ(3)-iodane intermediate.
authors.affiliation: Department of Chemistry, Graduate School of Science, Chiba University, Chiba 263-8522, Japan. moriyama@faculty.chiba-u.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Moriyama
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ishida
authors.forename: Hideo
authors.initials: H
authors.lastname: Togo