title: An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides.
abstract: Make it unique! A mixed-ligand system of Pd/Synphos/Xantphos promotes effective C-N coupling in the synthesis of various N-arylaminotriazole and N-arylaminopurine nucleoside analogues. This catalytic system is strikingly powerful and efficient, allowing for unparalleled substrate scope and high product yields as well as promotion of C-Cl bond activation for C-N coupling (see scheme).
authors.affiliation: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, PR China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Fan
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Jingjie
authors.initials: J
authors.lastname: Tang
authors.forename: Fabio
authors.initials: F
authors.lastname: Ziarelli
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
authors.forename: Juan L
authors.initials: JL
authors.lastname: Iovanna
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008024:Ligands; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry*
chemical_list: D008024:Ligands; D009705:Nucleosides; D010720:Phosphines; D014230:Triazoles; D014966:Xanthenes; D010165:Palladium; D002244:Carbon; D009584:Nitrogen; C519861:xantphos