title: Function after injection of benign bone lesions with a bioceramic.
abstract: BACKGROUND
  A novel calcium sulfate-calcium phosphate composite injectable bone graft substitute has been approved by the FDA for filling bone defects in a nonweightbearing application based on preclinical studies. Its utility has not been documented in the literature.
  
  
  OBJECTIVE
  We therefore determined postoperative function and complications in patients with benign bone lesions treated with this bioceramic.
  
  
  METHODS
  We retrospectively reviewed all 56 patients with benign bone lesions treated with the bioceramic from 2006 to 2008. There were 29 male and 27 female patients with an average age of 17.6 years (range, 4-63 years). They were treated for the following diagnoses: unicameral bone cyst (13), aneurysmal bone cyst (10), nonossifying fibroma (eight), fibrous dysplasia (five), enchondroma (four), chondroblastoma (four), and other (12). We obtained a Musculoskeletal Tumor Society (MSTS) functional evaluation on all patients. The minimum followup was 26 months (average, 42 months; range, 26-57 months).
  
  
  RESULTS
  The average MSTS score was 29 (range, 20-30). Most patients returned to normal function. There were three local recurrences, all of which were treated with repeat injection or curettage. Two patients had postoperative fractures treated in a closed manner. Two patients had wound complications, neither of which required removal of the graft material.
  
  
  CONCLUSIONS
  Patients treated with this material reported high MSTS functional scores more than 24 months after operative intervention and experienced low complication rates. We believe the novel bioceramic to be a reasonable treatment option for benign bone lesions.
authors.affiliation: Department of Orthopaedic Surgery, Rush University Medical Center, 1611 West Harrison Street, Chicago, IL 60612, USA.
authors.forename: Yale A
authors.initials: YA
authors.lastname: Fillingham
authors.forename: Brett A
authors.initials: BA
authors.lastname: Lenart
authors.forename: Steven
authors.initials: S
authors.lastname: Gitelis
mesh_terms: D000293:Adolescent; D000328:Adult; D001845:Bone Cysts / Q000628:therapy; D001847:Bone Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D001859:Bone Neoplasms / Q000628:therapy; D018786:Bone Substitutes / Q000008:administration & dosage*; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002133:Calcium Sulfate / Q000008:administration & dosage*; D002641:Chicago; D002648:Child; D002675:Child, Preschool; D002812:Chondroma / Q000628:therapy; D003131:Combined Modality Therapy; D003475:Curettage; D003646:Debridement; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000628:therapy; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D020127:Recovery of Function; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C020243:calcium phosphate; D002133:Calcium Sulfate