title: FAME, the Flux Analysis and Modeling Environment.
abstract: BACKGROUND
  The creation and modification of genome-scale metabolic models is a task that requires specialized software tools. While these are available, subsequently running or visualizing a model often relies on disjoint code, which adds additional actions to the analysis routine and, in our experience, renders these applications suboptimal for routine use by (systems) biologists.
  
  
  RESULTS
  The Flux Analysis and Modeling Environment (FAME) is the first web-based modeling tool that combines the tasks of creating, editing, running, and analyzing/visualizing stoichiometric models into a single program. Analysis results can be automatically superimposed on familiar KEGG-like maps. FAME is written in PHP and uses the Python-based PySCeS-CBM for its linear solving capabilities. It comes with a comprehensive manual and a quick-start tutorial, and can be accessed online at http://f-a-m-e.org/.
  
  
  CONCLUSIONS
  With FAME, we present the community with an open source, user-friendly, web-based "one stop shop" for stoichiometric modeling. We expect the application will be of substantial use to investigators and educators alike.
authors.affiliation: Systems Bioinformatics/AIMMS, VU University Amsterdam, De Boelelaan 1085, 1081HV, Amsterdam, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Boele
authors.forename: Brett G
authors.initials: BG
authors.lastname: Olivier
authors.forename: Bas
authors.initials: B
authors.lastname: Teusink
mesh_terms: D016678:Genome / Q000235:genetics*; D020407:Internet; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008954:Models, Biological; D012984:Software; D049490:Systems Biology / Q000379:methods*