title: Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia.
abstract: We assessed the comparative efficacy of empirical therapy with beta-lactam plus macrolide vs. beta-lactam plus doxycycline for the treatment of community-acquired pneumonia (CAP) among patients in the Australian Community-Acquired Pneumonia Study. Both regimens demonstrated similar outcomes against CAP due to either 'atypical' (Chlamydophila, Legionella or Mycoplasma spp.) or typical bacterial pathogens.
authors.affiliation: Department of Infectious Diseases, Austin Health, Heidelberg, Vic., Australia.
authors.forename: B
authors.initials: B
authors.lastname: Teh
authors.forename: M L
authors.initials: ML
authors.lastname: Grayson
authors.forename: P D R
authors.initials: PD
authors.lastname: Johnson
authors.forename: P G P
authors.initials: PG
authors.lastname: Charles
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D023501:Chlamydophila / Q000472:pathogenicity; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D004318:Doxycycline / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007875:Legionella / Q000472:pathogenicity; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009174:Mycoplasma / Q000472:pathogenicity; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult; D047090:beta-Lactams / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D047090:beta-Lactams; D004318:Doxycycline