title: Models of visceral pain: colorectal distension (CRD).
abstract: The visceromotor response to balloon distension of the colon is a robust behavioral model of visceral nociception in rodents and is ideally suited for studying the visceral antinociceptive activity of drugs. This unit describes, in detail, quantification of this response with the use of electromyography in both rats and mice.
authors.affiliation: The University of Iowa, Iowa City, Iowa, USA.
authors.forename: R Carter W
authors.initials: RC
authors.lastname: Jones
authors.forename: G F
authors.initials: GF
authors.lastname: Gebhart
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000818:Animals; D002404:Catheterization / Q000379:methods*; D003106:Colon / Q000502:physiology*; D004108:Dilatation, Pathologic / Q000503:physiopathology; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D004576:Electromyography / Q000295:instrumentation; D051379:Mice; D051381:Rats; D012007:Rectum / Q000502:physiology*; D013048:Specimen Handling; D059265:Visceral Pain / Q000209:etiology / Q000503:physiopathology*