title: Association of T869C gene  polymorphism  of transforming growth factor-β1 with low protein  levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women.
abstract: Osteoporosis  is the most common metabolic bone disease; it is an important health problem  among postmenopausal women. We evaluated the association of three  polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density  (BMD) serum TGF-β1  levels in 278 postmenopausal female osteopenia/osteoporosis subjects and 95  postmenopausal female control subjects. Serum TGF-β1 levels were significantly lower  in osteopenia/osteoporosis subjects than in control subjects. Serum TGF-β1 levels of the CT+CC (T869C)  genotype group were significantly lower in osteopenia/osteoporosis subjects  than in control subjects (11.3 vs 15.8 ng/mL). There was a significant  difference in the CT+CC (T869C) genotype frequencies between the  osteopenia/osteoporosis and control subjects (74.18 vs 60.22%; OR =  1.90, 95%CI = 1.16-3.12). In the age group of more than 50 years, subjects with  the TC+CC genotype of T869C polymorphism had significantly increased risk of  osteopenic/ osteoporotic bones at L1 (OR = 2.36, 95%CI = 1.37-4.07), L2 (OR =  1.71, 95%CI = 1.01-2.90), L3 (OR = 2.21, 95%CI = 1.23-3.98), L4 (OR = 1.74,  95%CI = 1.00-3.03) and the femoral neck (OR = 1.80, 95%CI = 1.04-3.12). The  CT+CC genotype of the T869C polymorphism of the TGF-β1 gene was found to be associated  with lower serum TGF-β1 in  osteopenia/osteoporosis subjects and increased risk of osteopenic and  osteoporotic fracture at L1-4, femoral neck and total hip in postmenopausal  Thai women. Logistic regression analysis showed that T869C polymorphism is a  significant risk factor for osteopenia/ osteoporosis. We concluded that T869C  polymorphism of the TGF-β1 gene  has an impact on decreased serum TGF-β1 levels and influences susceptibility to  osteopenia/osteoporosis in Thai women.
authors.affiliation: Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: D
authors.initials: D
authors.lastname: Utennam
authors.forename: A
authors.initials: A
authors.lastname: Tungtrongchitr
authors.forename: B
authors.initials: B
authors.lastname: Phonrat
authors.forename: R
authors.initials: R
authors.lastname: Tungtrongchitr
authors.forename: S
authors.initials: S
authors.lastname: Preutthipan
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013785:Thailand; D053773:Transforming Growth Factor beta1 / Q000097:blood* / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1; D004247:DNA