title: Mechanisms of hepatoprotective effect of immobilized granulocyte colony-stimulating factor.
abstract: The effect of immobilized granulocyte CSF on morphological characteristics and functional state of the liver was studied during chronic toxic hepatitis. The mechanisms of the therapeutic action of this agent were evaluated. The product had a strong hepatoprotective effect and exhibited the antiinflammatory and antisclerotic properties. The mechanism of activation of reserve systems for cell renewal (involved in restoration of the liver tissue) is probably related to an increase in proliferative activity of early precursor cells in the bone marrow, mobilization of these cells into the peripheral circulation, and directed homing into the liver tissue where they activate local regenerative mechanisms and prevent hepatocyte destruction. It should be emphasized that the concentration of SDF-1 increases in the liver tissue, but decreases in the bone marrow. These changes create the concentration gradient, which determines the migration of undifferentiated precursor cells to the liver.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E I
authors.initials: EI
authors.lastname: Vereshchagin
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: D N
authors.initials: DN
authors.lastname: Kinsht
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dubskaya
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000188:drug therapy* / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar
chemical_list: D054377:Chemokine CXCL12; D016179:Granulocyte Colony-Stimulating Factor