title: Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study.
abstract: There are conflicting results concerning the impact of maternal asthma during pregnancy on perinatal outcomes. The present study investigated the associations between maternal asthma during pregnancy and the risk of a small-for-gestational-age (SGA) infant, a low-birth-weight (LBW) infant, and preterm birth. A population-based cohort of 40,788 pregnancies from asthmatic and non-asthmatic women was reconstructed through the linking of three Quebec (Canada) administrative databases between 1990 and 2002. A two-stage sampling cohort design was used to collect additional information by way of a mailed questionnaire. The generalized estimation equation models were used to obtain adjusted odds ratios of SGA, LBW and preterm birth comparing asthmatic and non-asthmatic women. The cohort included 13,007 pregnancies from asthmatic and 27,781 pregnancies from non-asthmatic women. Final estimates showed that the odds of SGA (odds ratio: 1.27, 95% confidence interval: 1.14, 1.41), LBW (1.41: 1.22, 1.63) and preterm delivery (1.64: 1.46, 1.83) were significantly higher among asthmatic than non-asthmatic women. Mothers with asthma during pregnancy are more likely to have SGA, LBW, or preterm birth infants than non-asthmatic women. These results can be more easily generalized to women with lower socio-economic status since the cohort under represents women with high socio-economic status.
authors.affiliation: Faculty of Pharmacy, Université de Montréal, succursale Centre-ville, C.P. 6128, Montréal, QC, H3C 3J7, Canada.
authors.forename: Faranak
authors.initials: F
authors.lastname: Firoozi
authors.forename: Catherine
authors.initials: C
authors.lastname: Lemière
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Beauchesne
authors.forename: Sylvie
authors.initials: S
authors.lastname: Perreault
authors.forename: Amélie
authors.initials: A
authors.lastname: Forget
authors.forename: Lucie
authors.initials: L
authors.lastname: Blais
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000150:complications*; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications; D047928:Premature Birth / Q000209:etiology*; D011792:Quebec; D011795:Surveys and Questionnaires; D055815:Young Adult