title: GRACE risk score predicts contrast-induced nephropathy in patients with acute coronary syndrome and normal renal function.
abstract: We evaluated the incidence, clinical predictors, and outcomes of contrast-induced nephropathy (CIN) after coronary angiography in patients with myocardial infarction and normal kidney function. We studied 202 consecutive patients with glomerular filtration rate >60 mL/min/1.73 m(2). The CIN was defined according to 3 definitions: increases in serum creatinine (sCr) ≥25%, ≥0.3 mg/dL, and ≥0.5 mg/dL. The CIN occurred in 56 (27.7%), 42 (20.8%), and 13 (6.4%) patients, respectively. In multivariate analysis, the presence of a high Global Registry of Acute Coronary Events (GRACE) risk score (>140) was an independent predictor of CIN in its milder forms (≥25% and ≥0.3 mg/dL of rise in sCr). Increase in sCr ≥0.3 mg/dL was an independent predictor of bleeding. Increase in sCr ≥0.5 mg/dL was an independent predictor of in-hospital cardiac events (mortality, myocardial infraction [MI], and heart failure). As conclusion, the GRACE score is a useful tool to predict CIN in patients with MI and normal renal function.
authors.affiliation: Department of Cardiology, University Clinical Hospital of Santiago de Compostela, A Coruña, Spain. raposeiras26@hotmail.com
authors.forename: Sergio
authors.initials: S
authors.lastname: Raposeiras-Roubín
authors.forename: Pablo
authors.initials: P
authors.lastname: Aguiar-Souto
authors.forename: Cristina
authors.initials: C
authors.lastname: Barreiro-Pardal
authors.forename: Diego
authors.initials: D
authors.lastname: López Otero
authors.forename: Juliana
authors.initials: J
authors.lastname: Elices Teja
authors.forename: Raymundo
authors.initials: R
authors.lastname: Ocaranza Sanchez
authors.forename: Belen
authors.initials: B
authors.lastname: Cid Alvarez
authors.forename: Ramiro
authors.initials: R
authors.lastname: Trillo Nouche
authors.forename: María Victoria Reino
authors.initials: MV
authors.lastname: Maceiras
authors.forename: Emad
authors.initials: E
authors.lastname: Abu-Assi
authors.forename: José María
authors.initials: JM
authors.lastname: García-Acuña
authors.forename: José Ramón
authors.initials: JR
authors.lastname: González-Juanatey
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D003287:Contrast Media