title: [Endoscopic versus surgical treatment of infected necrotising pancreatitis: the TENSION study].
abstract: In patients with infected necrotising pancreatitis there is a significant risk (40%) of complications and mortality with the surgical step-up approach. This approach consists of percutaneous retroperitoneal drainage, if necessary followed by video-assisted retroperitoneal débridement. An alternative treatment is an endoscopic step-up approach consisting of endoscopic transluminal drainage, if necessary followed by endoscopic transluminal necrosectomy. The Dutch Pancreatitis Study Group has recently started the nationwide randomized TENSION-trial, in which in 98 patients the endoscopic step-up approach is compared with the surgical method. The primary endpoint is a composite of mortality and major morbidity (new onset organ failure, bleeding, perforation of a hollow organ or incisional hernia for which intervention is needed).
authors.affiliation: Universitair Medisch Centrum St Radboud, afd. OK/evidence based surgery, Nijmegen, the Netherlands. s.vanbrunschot@ok.umcn.nl
authors.forename: Sandra
authors.initials: S
authors.lastname: van Brunschot
authors.forename: Hjalmar C
authors.initials: HC
authors.lastname: van Santvoort
authors.forename: Hein G
authors.initials: HG
authors.lastname: Gooszen
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
mesh_terms: D002986:Clinical Trials as Topic; D003646:Debridement / Q000379:methods*; D004322:Drainage; D004724:Endoscopy / Q000379:methods*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures; D019283:Pancreatitis, Acute Necrotizing / Q000601:surgery*; D007507:Therapeutic Irrigation; D016896:Treatment Outcome; D020535:Video-Assisted Surgery