title: Prevalence and clinical predictors of insulin resistance in reproductive-aged thai women with polycystic ovary syndrome.
abstract: Objectives. To determine the prevalence of insulin resistance (IR) and its predictors in reproductive-aged Thai women with polycystic ovary syndrome (PCOS). Methods. A cross-sectional study was conducted from May 2007 to January 2009. Participants were 250 Thai women with PCOS. Information regarding medical history and physical examination and results of 75 gram OGTT were recorded. Results. The overall prevalence of IR was 20.0%, comprising the prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetic mellitus of 3.2%, 13.6%, and 5.6%, respectively. Multiple logistic regression analysis showed that the independent predictors for IR were age of ≥30 years old, waist circumference (WC) of ≥80 cm, presence of acanthosis nigricans (AN), and dyslipidemia with odds ratios (95% confidence interval) of 2.14 (1.01-4.52), 3.53 (1.28-9.75), 2.63 (1.17-5.88), and 3.07 (1.16-8.11), respectively. Conclusion. The overall prevalence of IR in reproductive-aged Thai women with PCOS is 20.0%. Age ≥30 years old, WC ≥80 cm, the presence of AN, and dyslipidemia are the significant clinical predictors.
authors.affiliation: Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Thanyarat
authors.initials: T
authors.lastname: Wongwananuruk
authors.forename: Manee
authors.initials: M
authors.lastname: Rattanachaiyanont
authors.forename: Suchada
authors.initials: S
authors.lastname: Indhavivadhana
authors.forename: Pichai
authors.initials: P
authors.lastname: Leerasiri
authors.forename: Kitirat
authors.initials: K
authors.lastname: Techatraisak
authors.forename: Prasong
authors.initials: P
authors.lastname: Tanmahasamut
authors.forename: Surasak
authors.initials: S
authors.lastname: Angsuwathana
authors.forename: Chongdee
authors.initials: C
authors.lastname: Dangrat