title: Systemic stress responses after laparoendoscopic single-site hepatectomy: a perspective controlled study.
abstract: OBJECTIVE
  This study aimed to evaluate the technical feasibility of laparoendoscopic single-site hepatectomy (LESH) and compared stress responses with laparoscopic hepatectomy (LH) through a perspective controlled trial.
  
  
  METHODS
  Thirty small female family pigs as animal models were divided into LESH and LH groups randomly. The data about operations including operating time, blood loss and complication rates were recorded. The stress indicators, including adrenaline, serum cortisol, interleukin-1, interleukin-6 and white blood cell count, were measured at baseline and 1, 24 and 48 hours postoperatively.
  
  
  RESULTS
  In LESH group, 1 case was converted to LH for uncontrolled blooding. The other 29 cases underwent respective operations successfully. Postoperative recovery was without complications. Mean operative time of LESH group and LH group was 94.7±31.3 vs. 76.9±24.3min (p=0.0929). The blood loss of two groups was 72.5±26.4 vs. 66.3±21.2mL and there was no statistical difference. In both groups stress indicators showed a rising trend after operations and had no significant differences at the same time point.
  
  
  CONCLUSIONS
  LESH is a safe, feasible and minimally invasive approach and has no different impact on stress responses compared to LH. It may be a reasonable alternative to apply in clinical practice by experienced laparoscopic physicians.
authors.affiliation: Department of Surgery, Tianjin Nankai Hospital, Tianjin, China.
authors.forename: Mingfang
authors.initials: M
authors.lastname: Qin
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zou
authors.forename: Mingwei
authors.initials: M
authors.lastname: Zheng
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000818:Animals; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy / Q000379:methods*; D013312:Stress, Physiological; D013552:Swine
chemical_list: D015850:Interleukin-6