title: Cutaneous lymphoepithelioma-like carcinoma: report of three cases.
abstract: BACKGROUND
  Cutaneous lymphoepithelioma-like carcinoma (cutaneous LELC) is an extremely rare malignant neoplasm with unclear histogenesis. Its histopathologic features are like those of lymphoepithelioma-like carcinoma occurring in the nasopharynx and in visceral organs especially salivary glands.
  
  
  METHODS
  The authors reported on one male and two female patients of cutaneous LELC with immunohistochemical and electron microscopic study. All patients were of old age. All cutaneous LELCs in this report occurred on the patient's face, one of each on the eyelid, conjunctiva, and cheek.
  
  
  RESULTS
  All resection specimens showed the typical histopathologic features of those of LELC, i.e. well-defined tumor lobules mainly located in the dermis and extending into the panniculus. These tumor lobules typically displayed ill-defined clusters/nests of large epitheloid cells with pale eosinophilic cytoplasm, atypical vesicular nuclei possessing prominent nucleoli and were surrounded by dense lymphoplasmacytic infiltration. Immunocytohistochemically, these epitheloid cells showed epithelial differentiation by the expression of epithelial membrane antigen (EMA), P63, CK5/6 and CAM5.2 but were negative to CK20, CEA and Ebstein-Barr virus (EBV). Squamous cell differentiation by the presence of desmosomes by electron microscopic study was also noted in two patients (case 1 and 3).
  
  
  CONCLUSIONS
  The findings described above indicated that cutaneous LELC was a malignant neoplasm exhibiting squamous cell differentiation.
authors.affiliation: Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sijmn@mahidol.ac.th
authors.forename: Jane
authors.initials: J
authors.lastname: Manonukul
authors.forename: Chanokpan
authors.initials: C
authors.lastname: Chotirat
authors.forename: Waranya
authors.initials: W
authors.lastname: Boonchai
authors.forename: Nusara
authors.initials: N
authors.lastname: Chomanee
authors.forename: Naree
authors.initials: N
authors.lastname: Choosrichom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005153:Facial Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*