title: Efficient one-pot, three-component synthesis of a library of pyrrolo[1,2-c]pyrimidine derivatives.
abstract: Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign alternative to classical methods. The new library of compounds was briefly characterized regarding the improved Lipinski rule to asses the potential drug-likeness of the compounds. The majority of compounds are statisfing the Lipinski rule.
authors.affiliation: Research Center Oltchim, Ramnicu Valcea, Romania.
authors.forename: Emilian
authors.initials: E
authors.lastname: Georgescu
authors.forename: Florentina
authors.initials: F
authors.lastname: Georgescu
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Popa
authors.forename: Constantin
authors.initials: C
authors.lastname: Draghici
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tarko
authors.forename: Florea
authors.initials: F
authors.lastname: Dumitrascu
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000098:Acetophenones; D011743:Pyrimidines; D011758:Pyrroles; C013190:phenacyl bromide