Sleep architecture impairment in epileptic children and putative role of anti epileptic drugs.
The comorbidity between epilepsy and sleep disorders is well documented. However, the mechanisms underlining this comorbidity are not fully understood. The putative role of anti epileptic drugs in sleep architecture disturbances in epileptic children needs to be explored. In this study, we analysed sleep architecture of 75 epileptic children (30 females and 45 males), aged from 4 to 15 years (mean-age: 8.3 years). They were divided in three groups according to their antiepileptic treatments: NT group: no antiepileptic treatment (n = 20), MT group: monotherapy (n = 29) and PT group: polytherapy (n = 26). All underwent video-polysomnographic recordings to assess main sleep parameters: stages of light sleep and slow waves sleep, REM sleep, total sleep time and awakenings. Percentages of paroxystic activity duration (PA) on TST were also calculated and classified in three subgroups: (<5%, 5% ≤ PA ≤ 20% and >20%). As result, significant decreases of REM sleep and of the sleep efficiency as well as significant increased awakenings were observed in PT group comparing to the NT group. No significative difference was found concerning the light sleep and slow waves sleep. A correlation was also observed between awakenings and PA. First, our data confirm that sleep disorders remain a hidden companion of childhood epilepsy. Second, we demonstrate that anti epileptic drugs may have some causal contribution. Diagnosing sleep disturbances should be part of the management of childhood epilepsy and should be taken into account in the choice of therapeutic strategy.
Paediatric Neurology Unit, Paediatric Department, Raymond Poincare Hospital, AP-HP University of Versailles-St-Quentin, Garches, France.
Valentina M
VM
Racaru
Fawzia
F
Cheliout-Heraut
Eric
E
Azabou
Nouha
N
Essid
Marc
M
Brami
Ileana
I
Benga
Jean-Marc
JM
Pinard
D000293:Adolescent; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000453:epidemiology; D012895:Sleep, REM / Q000502:physiology
D000927:Anticonvulsants