Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate.
We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masaya
M
Ishibashi
Taku
T
Fujimura
Akira
A
Hashimoto
Takahiro
T
Haga
Kaoru
K
Onami
Akira
A
Tsukada
Yumi
Y
Kambayashi
Takanori
T
Hidaka
Sadanori
S
Furudate
Ryoko
R
Shimada
Setsuya
S
Aiba