Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature.
BACKGROUND
Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin.


RESULTS
The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis of our medical records, we describe a series of 4 men with neuroendocrine laryngeal tumors treated in our department since 1994, including the first extremely aggressive and lethal laryngeal paraganglioma reported in the English-language literature. We also discuss the classification, the macro and microscopical characteristics, clinical and pathologic findings, and treatment of these neoplasms.


CONCLUSIONS
Although neuroendocrine laryngeal tumors account for approximately 1% of all neoplasms in the larynx, its majority represents very aggressive tumors showing a capacity for metastasis and portending poor outcome.
Otorhinolaryngology, Head and Neck Surgery Department, AHEPA University Hospital, Thessaloniki, Greece.
Nikolaos
N
Angouridakis
John
J
Goudakos
Georgia
G
Karayannopoulou
Stefanos
S
Triaridis
Angelos
A
Nikolaou
Konstantinos
K
Markou
D000368:Aged; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D013965:Thyroidectomy