In notch, one ANK repeat is not like the other.
In this issue of Structure, Choi et al. use hydrogen/deuterium exchange mass spectrometry to characterize a Notch transcription complex (NTC). When interpreted in the context of NTC X-ray structures, their findings reveal important molecular insights into the dynamics that underlie complex assembly.
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. kovallra@ucmail.uc.edu
Rhett A
RA
Kovall
D004268:DNA-Binding Proteins / Q000737:chemistry*; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000737:chemistry*; D051881:Receptor, Notch1 / Q000737:chemistry*; D014157:Transcription Factors / Q000737:chemistry*
D004268:DNA-Binding Proteins; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; C430872:MAML1 protein, human; C497761:NOTCH1 protein, human; C497570:RBPJ protein, human; D051881:Receptor, Notch1; D014157:Transcription Factors