[Time course of changes in functional visual acuity and ocular wavefront aberration after instillation of ofloxacin gel-forming ophthalmic solution].
OBJECTIVE
To investigate the influence of ofloxacin gel-forming ophthalmic solution on functional visual acuity (FVA) and ocular wavefront aberration.


METHODS
In the right eyes of 22 normal volunteers, FVA and ocular wavefront aberration were measured before and 1, 5, 10, 15, 30 minutes after the instillation of ofloxacin gel-forming ophthalmic solution (Gel group). Similar measurements were repeated after instillation of ofloxacin ophthalmic solution (Solution group) and ofloxacin ophthalmic ointment (Ointment group). The obtained data were compared among the three groups.


RESULTS
Although no significant changes in FVA and total ocular higher-order aberrations (HOAs) were observed in the Solution group, FVA and HOAs significantly deteriorated in the Gel group and Ointment group at 1 minute after instillation. These changes gradually returned to the baseline levels. These changes were remarkable in the Ointment group. FVA deteriorated significantly in the Ointment group as compared with the Gel group up to 5 minutes after instillation (p<0.0167).


CONCLUSIONS
Instillation of ofloxacin gel-forming ophthalmic solution significantly decreases FVA and increases HOAs, but these changes are less and shorter than the ofloxacin ophthalmic ointment.
Department of Ophthalmology, Ushiku Aiwa General Hospital.
Toshiya
T
Yamamoto
Takahiro
T
Hiraoka
Tetsuro
T
Oshika
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects*; D009824:Ointments; D009883:Ophthalmic Solutions; D012029:Refraction, Ocular / Q000187:drug effects*; D013997:Time Factors; D014792:Visual Acuity / Q000187:drug effects*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D005782:Gels; D009824:Ointments; D009883:Ophthalmic Solutions; D015242:Ofloxacin