Life-or-death decisions upon axonal damage.
In this issue of Neuron, Hu et al. (2012) report that upon axonal damage, CHOP and XBP1 unfolded protein response pathways are not recruited equally and have opposite effects on neuronal survival. XBP1 pathway boosting may represent a valuable neuroprotective strategy.
Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, Switzerland.
Francesco
F
Roselli
Pico
P
Caroni
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D020221:Optic Nerve Injuries / Q000473:pathology* / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*