A nanoforest structure for practical surface-enhanced Raman scattering substrates.
A nanoforest structure for surface-enhanced Raman scattering (SERS) active substrates is fabricated and analyzed. The detailed morphology of the resulting structure can be easily controlled by modifying the process parameters such as initial gold layer thickness and etching time. The applicability of the nanoforest substrate as a label-free SERS immunosensor is demonstrated using influenza A virus subtype H1N1. Selective binding of the H1N1 surface antigen and the anti-H1 antibody is directly detected by the SERS signal differences. Simple fabrication and high throughput with strong in-plane hot-spots imply that the nanoforest structure can be a practical sensing component of a chip-based SERS sensing system.
Department of Electrical Engineering, KAIST, Daejeon, Republic of Korea.
Myeong-Lok
ML
Seol
Sung-Jin
SJ
Choi
David J
DJ
Baek
Tae Jung
TJ
Park
Jae-Hyuk
JH
Ahn
Sang Yup
SY
Lee
Yang-Kyu
YK
Choi
D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry*; D007118:Immunoassay / Q000295:instrumentation*; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
D006046:Gold