The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients.
OBJECTIVE
The aim of this study was to evaluate the relationship of local intrarenal renin angiotensin system (RAS) with proteinuria in patients with renal AA amyloidosis.


METHODS
Thirty-two patients with renal AA amyloidosis (19 male, mean age: 45 ± 13 years) and sixteen healthy controls (5 male, mean age: 32 ± 5 years) were included in this study. Spot urine samples were obtained to measure urinary angiotensinogen (AGT) using human AGT-ELISA, urinary creatinine and protein levels. Logarithmic transformations of urinary AGT-creatinine ratio log(UAGT/Ucre) and urinary protein-to-creatinine ratio (UPCR) were done to obtain the normal distributions of these parameters.


RESULTS
Log(UAGT/UCre) was significantly higher in patients compared with the controls (1.88 ± 0.92 µg/g vs. 1.25 ± 0.70 µg/g; p = 0.023). Importantly a significantly positive correlation was found between log(UAGT/Ucre) and logUPCR in patients (r = 0.595, p = 0.006).


CONCLUSIONS
Urinary AGT levels are higher in renal AA amyloidosis patients than in controls. Also, there is a significant positive correlation between urinary AGT and proteinuria in renal AA amyloidosis.
Department of Nephrology, Ankara, Turkey. draysunaybal@yahoo.com
Aysun Aybal
AA
Kutlugün
Bulent
B
Altun
Umit
U
Aktan
Ercan
E
Turkmen
Mahmut
M
Altindal
Tolga
T
Yildirim
Rahmi
R
Yilmaz
Mustafa
M
Arici
Yunus
Y
Erdem
Cetin
C
Turgan
D000328:Adult; D000686:Amyloidosis / Q000209:etiology / Q000378:metabolism / Q000652:urine*; D000808:Angiotensinogen / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D010505:Familial Mediterranean Fever / Q000150:complications / Q000652:urine*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology / Q000378:metabolism / Q000652:urine; D012044:Regression Analysis; D000685:Serum Amyloid A Protein / Q000378:metabolism
D015415:Biomarkers; D000685:Serum Amyloid A Protein; D000808:Angiotensinogen; D003404:Creatinine