Structure-based search and in vitro analysis of self-cleaving ribozymes.
Detecting functional RNAs is increasingly accomplished through structure-based searches for patterns of conserved secondary structure. With large amounts of new sequencing data becoming available, there is a greater demand for efficient methods of identifying new RNAs. Here we present a method of identifying self-cleaving ribozymes and characterizing the in vitro activity.
Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Randi M
RM
Jimenez
Andrej
A
Lupták
D019295:Computational Biology / Q000379:methods*; D009843:Oligoribonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012984:Software; D014158:Transcription, Genetic; D014584:User-Computer Interface
D009843:Oligoribonucleotides; D016337:RNA, Catalytic