[Purinergic P2-receptors as potential targets of new pharmaceutical products].
P2-receptors are widespread in animal and human organs and tissues. Therefore, they attract much attention as potential targets of new drugs. This article presents in brief characteristics of P2 receptors and reviews the author's search for new antagonists of P2-receptors as well as his studies on the role of ectonucleotidases and unique temperature-dependence of P2 receptor activity. In addition, the presence and functional activity of P2 receptors in human uterus, fallopian tubes, heart and blood vessels are described. The possible physiological and pathophysiological role of P2 receptors in these tissues, as well as prospects for the development of drugs acting via P2 receptors is discussed.
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Ziganshin
D000255:Adenosine Triphosphate / Q000378:metabolism*; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D003080:Cold Temperature; D055808:Drug Discovery / Q000639:trends*; D005187:Fallopian Tubes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy / Q000639:trends; D058919:Purinergic P2 Receptor Antagonists / Q000627:therapeutic use*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000528:radiation effects; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D000255:Adenosine Triphosphate