A highly diastereoselective three-component tandem 1,4-conjugated addition-cyclization reaction to multisubstituted pyrrolidines.
A highly diastereoselective three-component tandem 1,4-conjugate addition-cyclization reaction of diazoacetophenones with anilines and unsaturated ketoesters was developed. The reaction provides general, easy, and highly efficient access to multisubstituted pyrrolidines in good yield with high diastereoselectivity.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062, China.
Xia
X
Zhang
Jingjing
J
Ji
Yingguang
Y
Zhu
Changcheng
C
Jing
Ming
M
Li
Wenhao
W
Hu
D000098:Acetophenones / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D003500:Cyclization; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000098:Acetophenones; D000814:Aniline Compounds; D011759:Pyrrolidines