Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment.
Mesoporous silica-coated gold nanorods (Au@SiO(2)) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO(2) is visualized through two-photon imaging. With doxorubicin hydrochloride loaded, Au@SiO(2)-DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power density laser-induced hyperthermia, which suggest the potential for in-vivo applications.
CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China.
Zhenjiang
Z
Zhang
Liming
L
Wang
Jing
J
Wang
Xiumei
X
Jiang
Xiaohui
X
Li
Zhijian
Z
Hu
Yinglu
Y
Ji
Xiaochun
X
Wu
Chunying
C
Chen
D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced; D008027:Light; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D010316:Particle Size; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
D017319:Photosensitizing Agents; D006046:Gold; D012822:Silicon Dioxide