Hypoxia-inducible factors in physiology and medicine.
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
Vascular Program, Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gsemenza@jhmi.edu
Gregg L
GL
Semenza
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D005075:Biological Evolution; D002908:Chronic Disease; D047108:Embryonic Development; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
D051792:Basic Helix-Loop-Helix Proteins; D010100:Oxygen