Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats.
Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and  retinopathy.
Department of Ophthalmology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, 100853, Beijing, China.
Yan
Y
Gong
Zhan-Ping
ZP
Chang
Ruo-Tong
RT
Ren
Shi-Hui
SH
Wei
Huan-Fen
HF
Zhou
Xiao-Fei
XF
Chen
Bao-Ke
BK
Hou
Xin
X
Jin
Mao-Nian
MN
Zhang