Lipoleiomyosarcoma of the larynx.
BACKGROUND
Lipoleiomyosarcoma is a rare tumor consisting of well-differentiated liposarcoma and leiomyosarcoma. The ear-nose-throat location of lipoleiomyosarcoma has not been previously described.


RESULTS
A 37-year-old man with a dysphagia had a dyspnea after an endoscopy. A large tumor was exteriorized from the man's mouth. The lesion was pedicled to the epiglottis. A histologic examination determined that the tumor was a lipoleiomyosarcoma. MDM2 and CDK4 gene amplification were positive. Due to the risk of recurrence, a second intervention was performed to complete the excision.


CONCLUSIONS
These tumors develop in cavities slowly and gradually. The treatment of this lesion is surgical with a sufficient resection margin.
Centre Hospitalier Régional et Universitaire de Tours, Service Oto-Rhino-Laryngologie et Chirurgie Cervico Faciale, Tours, France. jp.trijolet@univ-tours.fr
J P
JP
Trijolet
E
E
Lescanne
S
S
Morinière
A
A
Robier
D
D
Bakhos
D000328:Adult; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D007890:Leiomyosarcoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008297:Male; D021141:Nucleic Acid Amplification Techniques; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism
D051736:Proto-Oncogene Proteins c-mdm2; D051358:Cyclin-Dependent Kinase 4