Pyridine alkaloids from Senna multijuga as acetylcholinesterase inhibitors.
As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassiamultijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine.
Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química,  Universidade Estadual Paulista  (UNESP), P.O. Box 355, 14801-970, Araraquara, SP, Brazil.
Welington
W
Francisco
Marcos
M
Pivatto
Amanda
A
Danuello
Luis O
LO
Regasini
Luciene R
LR
Baccini
Maria C M
MC
Young
Norberto P
NP
Lopes
João L C
JL
Lopes
Vanderlan S
VS
Bolzani
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010830:Physostigmine / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029846:Senna Plant / Q000737:chemistry*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011725:Pyridines; D010830:Physostigmine