Resolution of recalcitrant uveitic optic disc edema following administration of methotrexate: two case reports.
A 13-year-old male and a 15-year-old female presented with optic disc edema associated with chronic recurrent uveitis. While the ocular inflammation responded to high doses of oral prednisolone, the disc edema showed little improvement. After oral administration of methotrexate, the disc edema and ocular inflammation were resolved, and the dose of oral corticosteroid could be reduced.
Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. sejoon1@snu.ac.kr
Se Joon
SJ
Woo
Mi Jeung
MJ
Kim
Kyu Hyung
KH
Park
Yun Jong
YJ
Lee
Jeong-Min
JM
Hwang
D000284:Administration, Oral; D000293:Adolescent; D002908:Chronic Disease; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D010211:Papilledema / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D012008:Recurrence; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008727:Methotrexate