3-(2,4-dimethoxybenzylidene)-anabaseine: a promising candidate drug for Alzheimer's disease?
3-(2,4-dimethoxybenzylidene)-anabaseine is an analog of the paralytic alkaloid, anabaseine, from the ribbon worms Amphiporus sp., that shows numerous properties, in particular an agonist activity on alpha 7 nicotinic acetylcholine receptors. This article reviews these properties and explains to what extent they could be valuable to control symptomatology and/or neurodegeneration in Alzheimer's disease.
Mines Paris Tech, Crises & Risk Research Centre, Orpéa/Clinéa, Puteaux cedex, France. p.zawieja@orpea.net
Philippe
P
Zawieja
Jean-Michel
JM
Kornprobst
Patrick
P
Métais
D000544:Alzheimer Disease / Q000188:drug therapy*; D001597:Benzylidene Compounds / Q000494:pharmacology*; D006801:Humans; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
D001597:Benzylidene Compounds; D018722:Nicotinic Agonists; D011725:Pyridines; C088936:3-(2,4-dimethoxybenzylidene)anabaseine