Superparamagnetic surface molecularly imprinted nanoparticles for water-soluble pefloxacin mesylate prepared via surface initiated atom transfer radical polymerization and its application in egg sample analysis.
The novel superparamagnetic surface molecularly imprinted Fe₃O₄@MIP nanoparticles for water-soluble pefloxacin mesylate (PEF-M) were prepared via surface initiated atom transfer radical polymerization (si-ATRP). The binary mixture of methanol and water was selected as the polar solvents for fabricating PEF-M imprinted MIPs. The Fe₃O₄@MIP exhibited high saturation magnetization of 41.4 emu/g leading to the fast separation. The adsorption behaviors indicated that the Fe₃O₄@MIP nanoparticles possessed specific recognition and high affinity towards template PEF-M in aqueous media. Moreover, Fe₃O₄@MIP nanoparticles were directly used to selectively enrich PEF-M from egg samples. By RP-HPLC analysis, the recoveries of PEF-M were obtained as 92.8-96.5% with relative standard division of 2.4-4.0%.
Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yongliang
Y
Liu
Yanyan
Y
Huang
Jizhong
J
Liu
Weizhi
W
Wang
Guoquan
G
Liu
Rui
R
Zhao
D019342:Acetic Acid / Q000737:chemistry; D000327:Adsorption; D000818:Animals; D002645:Chickens; D004350:Drug Residues / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D004531:Eggs / Q000032:analysis*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D000432:Methanol / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D015366:Pefloxacin / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D058185:Magnetite Nanoparticles; D015366:Pefloxacin; D019342:Acetic Acid; D000432:Methanol