When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media.
Of 368 acute otitis media (AOM) cases among 7-valent pneumococcal conjugate-vaccinated children, 43.5% were colonized by multiple otopathogens in the nasopharynx but only 7.1% experienced polymicrobial AOM. When co-colonization occurred, Haemophilus influenzae predominated over all Streptococcus pneumoniae strains except 19A strains to cause AOM. Haemophilus influenzae and Streptococcus pneumoniae both predominated over Moraxella catarrhalis to cause AOM.
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA.
Qingfu
Q
Xu
Janet R
JR
Casey
Arthur
A
Chang
Michael E
ME
Pichichero
D002353:Carrier State / Q000382:microbiology; D002675:Child, Preschool; D060085:Coinfection / Q000382:microbiology*; D005260:Female; D006192:Haemophilus Infections / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000254:growth & development / Q000472:pathogenicity*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D001936:Moraxella catarrhalis / Q000254:growth & development / Q000472:pathogenicity; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000254:growth & development / Q000472:pathogenicity*
D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines