Haplotype inference.
Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms. In this chapter, we introduce two representative methods to reconstruct haplotypes from unphased genotype data, one method is for unrelated individuals and the other is for families.
Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA.
Xin
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Li
Jing
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Li
D000465:Algorithms; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans