Alteration of functional state of peripheral blood erythrocytes in women of different age groups at dislipidemia conditions.
The aim of the study was identification of statistically reliable correlations and the cause-effect relationships between viability of red blood cells and dislipidema parametres and/or metabolic disorders, induced by age related alterations of estrogen content, in women of different ages (reproductive, menopausal)  On the basis of the analysis of research results we can conclude that in the different age groups of women with atherosclerosis-induced cardiovascular diseases revealed estrogen-related dependence between Tg-s and HDL content, functional status of phereperial blood erytrotcites and severity of dislipidemia. The aterogenic index Tg/HD proved to be sensitive marker of dislipidemia in reproductive aging women, but does't reflect disorders of lipid metabolism in postmenosal women.  It was proved the existence of reliable corelation between red blood cells dysfunction indicator, spherulation quality, and atherogenic index Tg/HDL highlights; however, the correlation coefficient is 2 times higher in the reproductive age as in menopause. Spherulation quality of red blood cells at low HDL content showd fast growth rate in reproductive-aged women, and was unsensetive to HDL content in postmenopasal women. It was concluded that age-related lack of estrogens in postmenopausal women indirectly contributes to decrease protection of red blood cells against oxidative damage, reduces their deformabelity and disturbances the rheological properties. So, Spherulation quality of red blood cells  may be used as a diagnostic marker of severity of atherosclerosis.
Tbilisi State Medical University, Life Research Center, Tbilisi, Georgia.
L
L
Ratiani
N
N
Intskirveli
G
G
Ormotsadze
T
T
Sanikidze
D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology; D002462:Cell Membrane / Q000473:pathology; D050171:Dyslipidemias / Q000097:blood* / Q000473:pathology; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008593:Menopause / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D014280:Triglycerides / Q000097:blood*
D008075:Lipoproteins, HDL; D014280:Triglycerides