Calcium signaling: deciphering the calcium-NFAT pathway.
Rapid cellular calcium oscillations activate gene expression hours later. How this temporal response amplification is achieved has until now been largely a mystery. An elegant combination of experimental strategies and a model that encompasses non-linear inputs and outputs now sheds new light on this long-standing problem.
National Institute of Environmental Health Sciences - NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. putney@niehs.nih.gov
James W
JW
Putney
D000818:Animals; D020013:Calcium Signaling; D005786:Gene Expression Regulation