Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells.
Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous efforts have been devoted towards the development of such humanized mouse models. This review is focused on human lymphohematopoietic reconstitution and immune function in humanized mice by cotransplantation of human fetal thymic tissue and CD34(+) cells. The potential use of these humanized mice in translational biomedical research is also discussed.
Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Zheng
Z
Hu
Yong-Guang
YG
Yang
D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000254:growth & development*; D051379:Mice; D008817:Mice, Mutant Strains; D013950:Thymus Gland / Q000637:transplantation*; D057170:Translational Research, Biomedical
D018952:Antigens, CD34