An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease.
OBJECTIVE
To investigate the peripheral blood eosinophilia (PBE) in the acute stage of incomplete Kawasaki disease (iKD).


METHODS
Twenty-four patients with iKD (median age; 31.5 months, range; 7-88 months) and 25 with complete Kawasaki disease (cKD) (median age; 37 months, range; 9-140 months) were evaluated between 2004 and 2010 from İzmir Dr. Behçet Uz Children's Hospital records retrospectively. We determined the eosinophil counts and rates from the complete blood count in two study groups before the IVIG treatment and 30 febrile age-matched controls and 30 control cases with congenital heart disease (control Group 1 and 2 respectively). Kruskal-Wallis test was performed in detecting the differences of eosinophil rates and counts between four subgroups.


RESULTS
In iKD group, the mean value of eosinophil rates and median value of eosinophil counts were 4.39±2.5% and 377 cells/mm(3), respectively, which did not significantly different with cKD group (mean eosinophil rates; 5.47±4.8% and median eosinophil counts 525 cells/mm(3)) (p>0.05). The median values of eosinophil cell counts and mean value of eosinophil rates were 220 cell/mm(3) and 2.83±2.65% in the control group 1 and 165 cell/mm(3) and 1.63±1.43% in the control Group 2 respectively, which were statistically significant lower compared to both study groups (p< 0.001).


CONCLUSIONS
The rate of PBE was found significantly higher in iKD patients compared to the controls. Since the diagnosis of iKD is difficult, unexplained eosinophilia may be helpful in the presence of suggestive clinical findings of KD.
Clinic of Pediatric Cardiology, İzmir Dr. Behçet Uz Children's Hospital, İzmir-Turkey.
Taliha
T
Öner
Murat Muhtar
MM
Yılmazer
Barış
B
Güven
Ilker
I
Devrim
Özgül Vupa
ÖV
Cilengiroğlu
Savaş
S
Demirpençe
Timur
T
Meşe
Vedide
V
Tavlı
Ayça
A
Vitrinel
D001772:Blood Cell Count; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology