Initial experiences with propranolol treatment of infantile hemangiomas: report of three cases.
Infantile hemangiomas (IH) are common benign tumors in infancy, affecting 5-10% of all infants and they can still cause disfigurement and serious complications depending on their location and size, which can be associated with ulcerations and haemorrhage. Since 2008, propranolol has become the first choice of therapy for complicated IH, compared to conventional approach with systemic corticosteroid therapy as first-line treatment and then interferon or vincristine as second- or third-line therapeutic agents. We report three cases of hemangioma, successfully treated with propranolol. Oral propranolol was given for a period of 6 months with monthly follow up. All cases showed dramatic response without any relapse after stopping the treatment. Propranolol is novel and safe medication for treatment of infantile hemangioma.
Department of Paediatric Surgery, Children's Hospital, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina. hamir@bih.net.ba
Amira
A
Halilbasic
Nrsad
N
Hotic
Edin
E
Husaric
Emir
E
Rahmanovic
Meliha
M
Halilbasic
Senada
S
Husaric
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D005260:Female; D006391:Hemangioma / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D014665:Vasodilator Agents; D011433:Propranolol