Circulating microRNAs in cancer: diagnostic and prognostic significance.
The involvement of microRNAs (miRs) in numerous pathological conditions is well established. In many kinds of cancer cells and animal models, various miRs have been shown to act as oncogenes or tumor suppressors. Recently, it was found that circulating miRs can be detected, and may be associated, with the clinicopathological features and prognosis of cancers, thus, providing potential novel diagnostic and prognostic markers for malignancies in humans. This review aims to address these issues based on recently published literature.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100730, China.
Li
L
Zhou
Yu-Pei
YP
Zhao
Wen-Jing
WJ
Liu
Jie
J
Dong
Wei-Yun
WY
Chen
Tai-Ping
TP
Zhang
Ge
G
Chen
Hong
H
Shu
D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology; D011379:Prognosis
D014408:Biomarkers, Tumor; D035683:MicroRNAs