Pityriasis rubra pilaris: evolution of challenges in promising treatment options.
Pityriasis rubra pilaris is an uncommon inflammatory dermatosis that is well recognized across the globe. Erythroderma is a common presentation. A precise diagnosis of pityriasis rubra pilaris is based on morphologic features and is classified into 6 types: classic adult onset (type I), atypical adult (type II), classic juvenile (type III), circumscribed juvenile (type IV), atypical juvenile (type V), and human immunodeficiency virus-associated (type VI). Several conventional systemic and/or topical treatments are currently in use. Largely, their results are unsatisfactory and limited by long-term toxicity. The authors investigate the efficacy of a wide spectrum of drugs by examining historical (archive) and promising (modern) treatment modalities for the treatment of pityriasis rubra pilaris.
Dermato Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Azadpur, Delhi, India. drsehgal@ndf.vsnl.net.in
Virendra N
VN
Sehgal
Govind
G
Srivastava
Prashant
P
Verma
D000279:Administration, Cutaneous; D003873:Dermatitis, Exfoliative / Q000188:drug therapy* / Q000209:etiology; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications; D006801:Humans; D010916:Pityriasis Rubra Pilaris / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D003879:Dermatologic Agents