Peptides regulate cortical thymocytes differentiation, proliferation, and apoptosis.
The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.
Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS pr. Dinamo 3, St. Petersburg 197110, Russia.
V Kh
VKh
Khavinson
V O
VO
Polyakova
N S
NS
Linkova
A V
AV
Dudkov
I M
IM
Kvetnoy