Polyproline and Tat transduction peptides in the study of the rapid actions of steroid receptors.
Cellular responses to signals require the action of a myriad of protein networks, which are regulated by protein/protein associations. Rapid actions of steroid hormones are also subject to this regulation. They induce direct association of steroid receptors with different proteins (e.g., growth factor receptors, signaling effectors, scaffold proteins, transcription factors). These multi-molecular complexes drive signaling activation and finally trigger basic hormonal effects. Receptor/protein associations are attracting increased interest concerning their role in hormone action as well as their potential use as therapeutic targets in hormonal diseases.
Department of General Pathology, II University of Naples, Via L. De Crecchio, 7-80138 Naples, Italy.
Antimo
A
Migliaccio
Gabriella
G
Castoria
Antonietta
A
de Falco
Antonio
A
Bilancio
Pia
P
Giovannelli
Marzia
M
Di Donato
Irene
I
Marino
Hiroshi
H
Yamaguchi
Ettore
E
Appella
Ferdinando
F
Auricchio
D021581:Active Transport, Cell Nucleus; D000595:Amino Acid Sequence; D000728:Androgens; D000818:Animals; D015696:Gene Products, tat / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism; D049790:Nuclear Export Signals; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011987:Receptors, Steroid / Q000378:metabolism*; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism
D000728:Androgens; D015696:Gene Products, tat; D049790:Nuclear Export Signals; D010446:Peptide Fragments; D010455:Peptides; D011987:Receptors, Steroid; C011083:polyproline; D019061:src-Family Kinases