[Some considerations of immune metabolism at preeclampsia].
The goal of the work is to determine several aspects of abnormalities and a part of immune metabolism in preeclampsia. In peripheral blood serum of all pregnant women at 20th week of gestation relative content of T-lymphocyte subpopulations, active T-lymphocytes and natural killers (NK) were detected by the method of indirect immunofluorescence and in cyto-toxic test using monoclonal antibodies to CD4 and CD84, CD 16 (T-cell markers of HLA-DR antigen of second class of MHC (marker of active T-lymphocytes, "ICN Pharmaceutical", USA).   According study results it can be concluded that at preeclampsia a content of NK cells in peripheral blood of pregnant women increases in the end of the second and early in the third trimesters on the background of significant decrease of general CD4 lymphocyte subpopulation. Received data allow to suppose that activation of natural killer cells (NK-cells) may be caused by the activation of cytotoxic Th-1 cells and their cytokines.
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Kintraia
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Sanikidze
D015703:Antigens, CD / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000378:metabolism; D017452:Receptors, IgG / Q000097:blood; D000071176:Signaling Lymphocytic Activation Molecule Family; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D015703:Antigens, CD; C498970:CD84 protein, human; D006684:HLA-DR Antigens; D017452:Receptors, IgG; D000071176:Signaling Lymphocytic Activation Molecule Family