[Immunological aspects of HCV/HIV coinfection].
OBJECTIVE
To evaluate effects of HCV/HIV coinfection on blood lymphocyte phenotype including cells CD56+.


METHODS
We studied standard immunogram, subpopulational composition and functional activity of blood cells CD56+ in 67 patients with verified diagnosis of HIV infection and virus hepatitis C.


RESULTS
We discovered some pathogenetically sound indices of immune status in patients with HCV/HIV coinfection. Some of the immune shifts detected changed in response to intake of narcotic drugs, antiretroviral treatment, hepatic cirrhosis, pneumonia.


CONCLUSIONS
Parameters of subpopulational composition and functional activity of cells CD56+ in the blood of patients with HCV/HIV coinfection elucidate some unknown features of the above infectious process which should be considered in this coinfection treatment and prophylaxis.
N D
ND
Iushchuk
I V
IV
Shestakova
I P
IP
Balmasova
M V
MV
Vysheslavtseva
E V
EV
Shmeleva
D000701:Analgesics, Opioid / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D019002:CD56 Antigen / Q000276:immunology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D011014:Pneumonia / Q000150:complications
D000701:Analgesics, Opioid; D000998:Antiviral Agents; D019002:CD56 Antigen