A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.
A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biological system was demonstrated in cell culture.
Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA.
Jianjun
J
Qi
Myung Shin
MS
Han
Ching-Hsuan
CH
Tung
D000480:Alkynes / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D002477:Cells / Q000737:chemistry; D003300:Copper / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D015394:Molecular Structure
D000480:Alkynes; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D003300:Copper; C005465:benzothiazole