Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system.
Blood group A tetrasaccharides of different types have the same terminal trisaccharide fragment that allows using a block scheme in their synthesis. 3-Aminopropyl glycosides of tetrasaccharides GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ (A type 1), GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcα (A type 3), and GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ (A type 4) were synthesised using acetylated Galα1-3(Fucα1-2)Gal trichloroacetimidate as a glycosyl donor at the key stage.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation.
Ivan M
IM
Ryzhov
Elena Yu
EY
Korchagina
Inna S
IS
Popova
Nicolai V
NV
Bovin
D000017:ABO Blood-Group System / Q000737:chemistry*; D002240:Carbohydrate Sequence; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
D000017:ABO Blood-Group System; D009844:Oligosaccharides