Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides.
The metalation of various SEM-protected functionalized indazoles with TMP(2)Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good yields.
Ludwig Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Andreas
A
Unsinn
Paul
P
Knochel
D002384:Catalysis; D007191:Indazoles / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D007191:Indazoles; D007454:Iodides; D010880:Piperidines; C551336:2,2,6,6-tetramethylpiperidide; D010165:Palladium; D015032:Zinc