Effectiveness of fresh frozen plasma as supplementary treatment in organophosphate poisoning.
With the establishment of the inadequate efficiency of atropines and oximes in reducing morbidity and mortality of patients poisoned by organophosphates, more attention is given to using other methods such as Fresh Frozen Plasma (FFP) as a bioscavenger to mop up organophosphate toxins. This randomized clinical trial was conducted on 56 organophosphate poisoned patients who were randomly assigned to the FFP and control groups in order of admission. The routine treatment in both groups included atropine and, in moderate to severe cases of poisoning, pralidoxime. The FFP group received four packs of FFP as stat dose at the beginning of treatment. No significant difference was seen between the two groups on the atropine and pralidoxime dosage, hospitalization length and mortality. The present study showed that using four packs of FFP as stat dose at the onset of treatment had no significant effect on the clinical course of organophosphate poisoned patients.
Arak University of Medical Sciences, Clinical Toxicology & Forensic Medicine, Vali Asr Hospital, Arak, Iran (Islamic Republic Of).
S
S
Pazooki
H
H
Solhi
H R Khoddami
HR
Vishteh
S
S
Shadnia
M J Bahram
MJ
Beigi
D000328:Adult; D001285:Atropine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D010949:Plasma; D011220:Pralidoxime Compounds / Q000627:therapeutic use
D011220:Pralidoxime Compounds; D001285:Atropine; C028797:pralidoxime