Highly Z-selective asymmetric conjugate addition of alkynones with pyrazol-5-ones promoted by N,N'-dioxide-metal complexes.
Highly selective: the title reaction is achieved with high enantiomeric and geometric control and thermodynamically unstable (Z)-enone derivatives are obtained as the major products. The procedure tolerates a wide range of substrates to generate optically active pyrazolones with vinyl-substituted quaternary stereocenters.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Zhen
Z
Wang
Zhenling
Z
Chen
Sha
S
Bai
Wei
W
Li
Xiaohua
X
Liu
Lili
L
Lin
Xiaoming
X
Feng