A case of IgG4-related pulmonary disease with rapid improvement.
We report a 72-year-old man with respiratory involvement of immunoglobulin G4 (IgG4)-related disease, who developed dry cough and shortness of breath on effort. The chest computed tomography scan image showed massive and diffuse ground-glass opacity, interlobular thickening, and bronchial wall thickening. The infiltration of IgG4-positive plasma cells in the transbronchial lung biopsy and high serum IgG4 concentrations were found. The patient was treated with 0.6 mg/kg oral prednisolone and showed rapid improvement. This is a case of IgG4-related disease in which the only complication was respiratory involvement.
Department of Rheumatology, Isahaya Health Insurance General Hospital, Isahaya, Nagasaki, Japan.
Masataka
M
Umeda
Keita
K
Fujikawa
Tomoki
T
Origuchi
Toshiaki
T
Tsukada
Akira
A
Kondo
Shinya
S
Tomari
Yuichi
Y
Inoue
Hisashi
H
Soda
Hideki
H
Nakamura
Shoko
S
Matsui
Atsushi
A
Kawakami
D000368:Aged; D001980:Bronchi / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008171:Lung Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D016896:Treatment Outcome
D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D011239:Prednisolone