Genome sequence of the fungus Glarea lozoyensis: the first genome sequence of a species from the Helotiaceae family.
The anamorphic fungus Glarea lozoyensis mutant strain 74030 is an overproducer of pneumocandin B(0), which is chemically converted into Cancidas, a potent antibiotic against clinically important fungal pathogens. Pneumocandins are acylated, cyclic hexapeptides with unusual hydroxylated amino acids. With the Glarea lozoyensis genome, the first species from the large polyphyletic family Helotiaceae has been sequenced.
Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, University of Freiburg, Freiburg, Germany.
Loubna
L
Youssar
Björn Andreas
BA
Grüning
Anika
A
Erxleben
Stefan
S
Günther
Wolfgang
W
Hüttel
D001203:Ascomycota / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry
D010456:Peptides, Cyclic