Ethyl pyruvate improves healing of colonic anastomosis in a rat model of peritonitis.
BACKGROUND
This study was designed to evaluate the effects of ethyl pyruvate (EP) on wound healing in primary colonic anastomoses in intraperitoneal sepsis.


METHODS
Standard left colon resection and end-to-end anastomosis were performed on 30 rats. They were grouped as control (C)--no further treatment; sepsis (S)--received 2 mL Escherichia coli (ATCC 25922) intraperitoneally (IP), and after 5 hours, standard resection and anastomosis were performed; or sepsis-group treated with EP (S-EP)--received 2 mL E coli IP, after 5 hours, standard resection and anastomosis were performed and treated with EP 50 mg/kg IP for 7 days. On the postoperative day 7, the animals were sacrificed.


RESULTS
The anastomosis bursting pressure in group S was significantly lower than in the other groups. There were no differences between groups C and S-EP. Tissue hydroxyproline concentrations in group C were significantly higher than in group S.


CONCLUSIONS
EP administration prevented intraperitoneal sepsis-induced impaired anastomotic healing of colon.
Department of General Surgery, Fatih Sultan Mehmet Education and Research Hospital, Istanbul 84410, Turkey. ozberkozge@gmail.com
Ender
E
Onur
Berkant
B
Akalin
Kemal
K
Memisoglu
Aziz Bora
AB
Karip
Mehmet Timucin
MT
Aydin
Hasan
H
Altun
Baki
B
Ekci
D000704:Analysis of Variance; D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D003106:Colon / Q000601:surgery*; D004195:Disease Models, Animal; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D010538:Peritonitis / Q000473:pathology*; D011312:Pressure; D011773:Pyruvates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D011773:Pyruvates; C046522:ethyl pyruvate; D006909:Hydroxyproline