Reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride and biological activities of the products.
A series of novel compounds were synthesized in reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H(1)  NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti-inflammatory activities were experimentally verified.
Faculty of Pharmacy, Department of Organic Chemistry, Nicolaus Copernicus University, Bydgoszcz, Poland.
Bozena
B
Modzelewska-Banachiewicz
Marzena
M
Ucherek
Michał
M
Zimecki
Jolanta
J
Kutkowska
Teresa
T
Kaminska
Beata
B
Morak-Młodawska
Renata
R
Paprocka
Michał
M
Szulc
Grzegorz
G
Lewandowski
Joanna
J
Marciniak
Teresa
T
Bobkiewicz-Kozlowska
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000812:Anhydrides / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000577:Amides; D000812:Anhydrides; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D003509:Cyclohexanecarboxylic Acids; D003998:Dicarboxylic Acids; D006835:Hydrazones; C534517:cyclohexane-1,2-dicarboxylic acid