Gender bias in skin cancer: role of catalase revealed.
Sullivan et al. describe their finding that lower skin catalase activity in male as compared with female mice may be responsible for the increased skin carcinogenesis observed in UVB radiation-exposed male mice. This adds to the growing literature that points toward a gender bias in the pathogenesis of skin cancer. Delineating the events between UV exposure and carcinogenesis in relation to skin's antioxidant activity will provide insight into disease progression, prognosis, and responses to therapy. If substantiated with further studies in humans, this information may aid in designing gender-specific preventive measures aimed at reversing immune suppression through targeting the altered redox status in UV-exposed individuals.
Department of Dermatology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Deeba N
DN
Syed
Hasan
H
Mukhtar
D000818:Animals; D002374:Catalase / Q000528:radiation effects*; D005260:Female; D008297:Male; D022423:Myeloid Cells / Q000473:pathology* / Q000528:radiation effects*; D012867:Skin / Q000201:enzymology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D002374:Catalase