Exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein in normal healthy subjects but not in persons with spinal cord injury.
OBJECTIVE
To compare plasma concentrations of oxidized low-density lipoprotein (oxLDL) and adrenaline during exercise between persons with spinal cord injury (SCI) and able-bodied (AB) individuals.


METHODS
Randomized controlled study.


METHODS
Human laboratory at a medical university.


METHODS
Persons with SCI (n=7) and AB individuals (n=9).


METHODS
Two-hour arm crank ergometer exercise at 60% maximum oxygen consumption.


METHODS
Plasma oxLDL and adrenaline levels.


RESULTS
Exercise significantly increased plasma adrenaline levels in AB persons (mean ± SD: rest, 45.4±32.2 pg/mL; exercise, 200.9±113.7 pg/mL; P<.05) and persons with SCI; however; the magnitude of the increase in those with SCI was attenuated (mean ± SD: rest, 45.4±14.0 pg/mL; exercise, 83.0±55.8 pg/mL; P<.05). Exercise also significantly increased plasma oxLDL levels in AB persons (mean ± SD: rest, 102.2±30.2 U/L; exercise, 179.7±60.0 U/L; P<.05), but not in persons with SCI (mean ± SD: rest, 124.3±66.0 U/L; exercise, 138.9±59.5 U/L).


CONCLUSIONS
The results suggest that increases in plasma adrenaline levels during exercise contribute to the increase in plasma oxLDL levels.
Institute of Sports Science and Environmental Physiology, Wakayama Medical University, Wakayama, Japan.
Toshihito
T
Mitsui
Takeshi
T
Nakamura
Tomoyuki
T
Ito
Yasunori
Y
Umemoto
Keiko
K
Sakamoto
Tokio
T
Kinoshita
Masafumi
M
Nakagawa
Fumihiro
F
Tajima
D000328:Adult; D000704:Analysis of Variance; D004837:Epinephrine / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010264:Paraplegia / Q000097:blood*; D013119:Spinal Cord Injuries / Q000097:blood*
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D004837:Epinephrine