Development of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the murid host: evidence for larval growth in striated muscle fibres.
Trichosomoides nasalis (Trichinelloidea) is a parasite of Arvicanthis niloticus (Muridae) in Senegal. Female worms that harbour dwarf males in their uteri, occur in the epithelium of the nasal mucosa. Young laboratory-bred A. niloticus were either fed females containing larvated eggs or intraperitoneally injected with motile first-stage larvae recovered from female uteri. Both resulted in successful infection. Organs examined during rodent necropsy were blood and lymphatic circulatory systems (heart, large vessels, lymphnodes), lungs, liver, kidneys, thoracic and abdominal cavities, thoracic and abdominal muscular walls, diaphragm, tongue, and nasal mucosa. Development to adult nasal stages took three weeks. Recovery of newly hatched larvae from the peritoneal fluid at four-eight hours after oral infection suggests a direct passage from the stomach or intestinal wall to the musculature. However, dissemination through the blood, as observed with Trichinella spiralis, cannot be excluded even though newly hatched larvae of T. nasalis are twice as thick (15 μm). Developing larvae were found in histological sections of the striated muscle of the abdominal and thoracic walls, and larvae in fourth moult were dissected from these sites. Adult females were found in the deep nasal mucosa where mating occurred prior to worms settling in the nasal epithelium. The present study shows a remarkable similarity between T. nasalis and Trichinella species regarding muscle tropism, but the development of T. nasalis is not arrested at the late first-larval stage and does not induce transformation of infected fibres into nurse cells. T. nasalis seems a potential model to study molecular relations between trichinelloid larvae and infected muscle fibres.
Département de Biologie Animale, Université Cheikh Anta Diop de Dakar, BP5005 Dakar, Sénégal.
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Fall
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Diagne
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Junker
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Duplantier
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Vallée
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Bain
D034861:Abdominal Wall / Q000469:parasitology; D000818:Animals; D017158:Enoplida / Q000254:growth & development* / Q000502:physiology; D017189:Enoplida Infections / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D007814:Larva / Q000254:growth & development / Q000502:physiology; D008297:Male; D018978:Molting; D051189:Murinae / Q000469:parasitology*; D054792:Muscle, Striated / Q000469:parasitology; D009297:Nasal Mucosa / Q000469:parasitology*; D009668:Nose Diseases / Q000469:parasitology / Q000662:veterinary; D012376:Rodent Diseases / Q000469:parasitology*