High incidence of internal malignancy in papuloerythroderma of Ofuji: a case series from Japan.
BACKGROUND
Although it has been reported that papuloerythroderma of Ofuji (PEO) often occurs in association with internal malignancy, the true incidence of malignancy in patients with PEO is unknown.


OBJECTIVE
To ascertain the incidence of and relationship with internal malignancy in patients with PEO, 11 patients with PEO diagnosed at our dermatology clinic between September 2005 and June 2011 were retrospectively reviewed.


RESULTS
Internal malignancy was found in 6 (54.5%) of the 11 PEO patients, and 5 cases were idiopathic PEO. In the 6 cases with associated malignancy, PEO preceded the malignancies, and the diagnosis of malignancy was made just before or shortly after the diagnosis of PEO, but the malignant process and PEO did not always run a parallel course.


CONCLUSIONS
Although the limitations of this study included a relatively small sample size, the present findings show a high incidence of internal malignancy in patients with PEO.
Department of Dermatology, Saitama Medical University, Saitama Medical Center, Kawagoe, Japan. teraki@saitama-med.ac.jp
Yuichi
Y
Teraki
Yuko
Y
Aso
Yoshihiro
Y
Sato
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000473:pathology; D011701:PUVA Therapy / Q000379:methods*; D012189:Retrospective Studies; D017444:Skin Diseases, Papulosquamous / Q000150:complications* / Q000188:drug therapy
D005938:Glucocorticoids; D006633:Histamine Antagonists