Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review.
Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE.
Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Casey M
CM
O'Dell
Arabinda
A
Das
Gerald
G
Wallace
Swapan K
SK
Ray
Naren L
NL
Banik
D000248:Adenosine Kinase / Q000378:metabolism; D000818:Animals; D032882:Comprehension; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology / Q000628:therapy*; D005911:Gliosis / Q000209:etiology; D006801:Humans; D019599:Mossy Fibers, Hippocampal / Q000503:physiopathology; D009410:Nerve Degeneration / Q000209:etiology; D012640:Seizures / Q000209:etiology / Q000628:therapy*
D016207:Cytokines; D000248:Adenosine Kinase