Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa.
The acute and chronic toxicological effects of carbamazepine (CBZ) on Scenedesmus obliquus and Chlorella pyrenoidosa were explored for the first time in this study. The results showed that CBZ could significantly inhibit the growth of the two algae in almost all treatment groups. EC(50) values indicated that, CBZ had a relatively limited acute toxic effect (0-144 h) on S. obliquus and C. pyrenoidosa, while, chronic tests (5-30 d) displayed higher toxicity. Chlorophyll a syntheses were nearly all inhibited by CBZ exposure. However, superoxide dismutase (SOD) and catalase (CAT) activities in acute tests of both algae were markedly promoted. According to the results, Chlorophyll a content and CAT activity of S. obliquus were more sensitive to CBZ than that of C. pyrenoidosa. While for SOD, quite to the contrary, C. pyrenoidosa was more vulnerable. We obtained a similar result in chronic tests. This research furthers our understanding of CBZ toxicity to aquatic organisms.
School of Resource and Environmental Engineering/Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, PR China. wzhang@ecust.edu.cn
Wei
W
Zhang
Meng
M
Zhang
Kuangfei
K
Lin
Wenfang
W
Sun
Bang
B
Xiong
Meijin
M
Guo
Xinhong
X
Cui
Rongbing
R
Fu
D015415:Biomarkers / Q000378:metabolism; D002220:Carbamazepine / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D002708:Chlorella / Q000187:drug effects* / Q000254:growth & development; D002734:Chlorophyll / Q000096:biosynthesis; D000077194:Chlorophyll A; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D018570:Risk Assessment; D044444:Scenedesmus / Q000187:drug effects* / Q000254:growth & development; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D015415:Biomarkers; D014874:Water Pollutants, Chemical; D002734:Chlorophyll; D002220:Carbamazepine; D002374:Catalase; D013482:Superoxide Dismutase; D000077194:Chlorophyll A