Metabolic syndrome and dementia associated with Parkinson's disease: impact of age and hypertension.
OBJECTIVE
To determine correlations between age and metabolic disorders in Parkinson's disease (PD) patients.


METHODS
This observational cross-sectional study included brief tests for dementia and the Mattis test. Signals of metabolic syndrome were evaluated.


RESULTS
There was no significant effect from the presence of hypertension (OR=2.36 for patients under 65 years old and OR=0.64 for patients over 65), diabetes or hypercholesterolemia regarding occurrences of dementia associated with PD (24% of the patients). The study demonstrated that each year of age increased the estimated risk of dementia in PD patients by 9% (OR=1.09; 95%CI: 1.01-1.17).


CONCLUSIONS
There was no evidence to correlate the presence of metabolic syndrome with the risk of dementia that was associated with PD. The study confirmed that dementia in PD is age dependent and not related to disease duration.
Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, São Paulo State University "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
Arthur Oscar
AO
Schelp
Cristiane Lara
CL
Mendes-Chiloff
Rodrigo
R
Bazan
Vanessa Cristina
VC
Paduan
Ana Beatriz Maringolo
AB
Pioltini
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003704:Dementia / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012959:Socioeconomic Factors; D013997:Time Factors