Nonoperative management of scleroderma of the hand with tadalafil and subatmospheric pressure wound therapy: case report.
Scleroderma, or systemic sclerosis (SS), is an autoimmune disease leading to ischemic fibrosis and widespread collagen deposition, invariably affecting the hands. Optimized medical management remains the mainstay of therapy for SS. Surgery can be considered in refractory or severely disabling cases. However, microvascular insufficiency and fibrosis can lead to wound complications and, ultimately, amputation. We present the case of a 61-year-old man with a known history of scleroderma who presented with pain, chronic infection, and ulcerations in the left hand. Initially, amputation seemed a reasonable intervention. After medical optimization with tadalafil, his ulcerations persisted. Instead of amputation, we applied a subatmospheric pressure wound therapy device to his hand. In 4 months, his wounds had healed, there was no evidence of infection, and no digits were amputated.
Chicago Center for Surgery of the Hand, Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. rmpatel7@gmail.com
Ronak M
RM
Patel
Daniel J
DJ
Nagle
D000328:Adult; D002243:Carbolines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006225:Hand / Q000098:blood supply; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000628:therapy*; D000068581:Tadalafil; D014945:Wound Healing
D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil