[Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease].
Thiopurine drugs have been widely used in the treatment of inflammatory bowel disease. However, their use is limited by adverse effect that can lead to cessation of therapy. We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease. Both patients complained of abdominal pain, showed elevated pancreatic enzymes, and swollen pancreases on computed tomography. The patients' signs and symptoms resolved uneventfully after withdrawal of the thiopurine drugs. Although the mechanism of thiopurine-induced pancreatitis remains unclear, close monitoring and early recognition of acute pancreatitis is important in the management of new thiopurine users.
Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan. junnishi@med.u-toyama.ac.jp
Jun
J
Nishikawa
Takahiko
T
Kudo
Takako
T
Miyazaki
Hiroshi
H
Mihara
Akira
A
Ueda
Takayuki
T
Ando
Shinya
S
Kajiura
Haruka
H
Fujinami
Kohei
K
Ogawa
Ayumu
A
Hosokawa
Toshiro
T
Sugiyama
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy*; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced*
D015122:Mercaptopurine; D001379:Azathioprine