Non-coding RNAs in retinal development.
Retinal development is dependent on an accurately functioning network of transcriptional and translational regulators. Among the diverse classes of molecules involved, non-coding RNAs (ncRNAs) play a significant role. Members of this family are present in the cell as transcripts, but are not translated into proteins. MicroRNAs (miRNAs) are small ncRNAs that act as post-transcriptional regulators. During the last decade, they have been implicated in a variety of biological processes, including the development of the nervous system. On the other hand, long-ncRNAs (lncRNAs) represent a different class of ncRNAs that act mainly through processes involving chromatin remodeling and epigenetic mechanisms. The visual system is a prominent model to investigate the molecular mechanisms underlying neurogenesis or circuit formation and function, including the differentiation of retinal progenitor cells to generate the seven principal cell classes in the retina, pathfinding decisions of retinal ganglion cell axons in order to establish the correct connectivity from the eye to the brain proper, and activity-dependent mechanisms for the functionality of visual circuits. Recent findings have associated ncRNAs in several of these processes and uncovered a new level of complexity for the existing regulatory mechanisms. This review summarizes and highlights the impact of ncRNAs during the development of the vertebrate visual system, with a specific focus on the role of miRNAs and a synopsis regarding recent findings on lncRNAs in the retina.
MRC Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Nicola A
NA
Maiorano
MRC Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Robert
R
Hindges
D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D022661:RNA, Untranslated / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012160:Retina / Q000254:growth & development* / Q000378:metabolism; D012164:Retinal Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D043244:Ribonuclease III / Q000235:genetics / Q000378:metabolism
D022661:RNA, Untranslated; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases