Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile.
Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer MBL2*B genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01-5.4, P = 0.047) but did not differ with manifestation. In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; P = 0.02). TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against Trypanosoma cruzi infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC.
Laboratorio Clinico, Clinica Alemana/Universidad de Desarrollo, Santiago, Chile. tweitzel@alemana.cl
Thomas
T
Weitzel
Inés
I
Zulantay
Ina
I
Danquah
Lutz
L
Hamann
Ralf R
RR
Schumann
Werner
W
Apt
Frank P
FP
Mockenhaupt
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D002908:Chronic Disease; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007113:Immunity, Innate; D007223:Infant; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4