Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome.
OBJECTIVE
Metabolic syndrome (MetS) is an insulin-resistance syndrome deeply associated with obesity. The association between MetS and several clinical factors, including serum levels of adiponectin, C-reactive protein and insulin, was examined.


METHODS
The study was performed in 219 men aged 43.2 ± 6.6 years, who were employees of a company. The study measured the serum high sensitivity C-reactive protein (CRP) as an inflammatory marker, serum insulin as a marker of insulin resistance and serum high-molecular-weight adiponectin (HMW-adipo), in addition to the serum levels of liver enzymes and uric acid. MetS was diagnosed according to the National Cholesterol Education Programme ATPIII criteria.


RESULTS
Log-transformed serum ALT, HMW-adipo, insulin and uric acid were found to be significantly related to the presence/absence of Mets by logistic regression analysis, with odds ratios (95% confidence intervals) of 25.9 (3.3-204.4), 0.10 (0.02-0.56), 7.5 (1.6-34.1) and 1.5 (1.04-2.1), respectively.


CONCLUSIONS
Serum high HMW-adipo level was significantly negatively related to the presence of MetS, independently of the serum levels of insulin, liver enzymes and uric acid. Among the markers examined, serum HMW-adipo and ALT were considered as markers for MetS.
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan. kawada@nms.ac.jp
Tomoyuki
T
Kawada
Miyuki
M
Hasegawa
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D014527:Uric Acid / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D007328:Insulin; D014527:Uric Acid; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase