The Nogo-66 receptor family in the intact and diseased CNS.
The Nogo-66 receptor family (NgR) consists in three glycophosphatidylinositol (GPI)-anchored receptors (NgR1, NgR2 and NgR3), which are primarily expressed by neurons in the central and peripheral mammalian nervous system. NgR1 was identified as serving as a high affinity binding protein for the three classical myelin-associated inhibitors (MAIs) Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), which limit axon regeneration and sprouting in the injured brain. Recent studies suggest that NgR signaling may also play an essential role in the intact adult CNS in restricting axonal and synaptic plasticity and are involved in neurodegenerative diseases, particularly in Alzheimer's disease pathology through modulation of β-secretase cleavage. Here, we outline the biochemical properties of NgRs and their functional roles in the intact and diseased CNS.
Division of Neurobiochemistry, Biocenter, Innsbruck Medical University, Fritz-Pregl-Str3, 6020 Innsbruck, Austria.
Sarah C
SC
Borrie
Bastian E
BE
Baeumer
Christine E
CE
Bandtlow
D000818:Animals; D001369:Axons / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D005810:Multigene Family; D009473:Neuronal Plasticity / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
D011956:Receptors, Cell Surface