Acute Effects of Acu-TENS on FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease.
Background  Pharmacotherapy is the mainstay of dyspnea management in patients with chronic obstructive pulmonary disease (COPD). Undesirable side effects have led to the application of alternative treatment strategies such as acupuncture. Our previous study showed that transcutaneous electrical nerve stimulation over acupuncture points (Acu-TENS), a noninvasive modality, can reduce dyspnea symptoms in patients with COPD, but the underlying mechanism is unknown. Primary Study Objective  This study investigated the effect of acu-TENS on forced expiratory volume in one second (FEV1), dyspnea, and Β-endorphin levels in patients with COPD. Design  A double-blinded randomized controlled trial Setting: Hospital outpatient clinic Participants  Forty-four subjects diagnosed with COPD Intervention  Participants were randomly assigned to receive either acu-TENS or placebo-TENS on Dingchuan (EX-B1) for 45 minutes. Outcome Measures  FEV1, forced vital capacity (FVC), dyspnea visual analogue score (DVAS), respiratory rate (RR), and blood Β-endorphin levels were measured before and after therapeutic intervention. Results  Our findings showed that the increase in FEV1 was 24.2% greater in the acu-TENS group than the placebo group (P < .0001). The decrease in RR and DVAS was also more in the acu-TENS group by 14.2% (P < .0001) and 20.7% (P = .006), respectively. The postintervention increase in Β-endorphin was significantly higher in the acu-TENS than the placebo group (18.3%) (P = .027). Furthermore, the percentage reduction in RR correlated with the increase in Β-endorphin (R = -0.477, P = .033). Conclusion  An improvement in FEV1 and dyspnea score at the end of Acu-TENS treatment was associated with a concurrent increase in b-endorphin level in patients with COPD.
Alice Y M
AY
Jones
Shirley P C
SP
Ngai
Christina W Y
CW
Hui-Chan
Homer P M
HP
Yu
D015669:Acupuncture Points; D005541:Forced Expiratory Volume; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy; D004561:Transcutaneous Electric Nerve Stimulation; D001615:beta-Endorphin
D001615:beta-Endorphin