Pd-catalyzed dehydrogenative cross-coupling of polyfluoroarenes with heteroatom-substituted enones.
The first example of intermolecular regioselective α-arylation of heteroatom-substituted enones with polyfluoroarenes via twofold C-H bond functionalization using a palladium catalyst is reported. This approach provides rapid access to a wide range of α-fluoroarylated enones of interest in life science.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Fei
F
Chen
Zhang
Z
Feng
Chun-Yang
CY
He
Hao-Yang
HY
Wang
Yin-long
YL
Guo
Xingang
X
Zhang
D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D017611:Fluorine Compounds / Q000737:chemistry*; D006865:Hydrogenation; D007700:Kinetics; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D017611:Fluorine Compounds; D010165:Palladium; D001554:Benzene