Modification of chitosan membrane with poly(vinyl alcohol) and biocompatibility evaluation.
This work aimed to overcome chitosan (CS) membrane' drawbacks: mainly stiffness and hydrophobic surface by adding poly(vinyl alcohol) (PVA) and evaluate their biocompatibility. The chemical structure, crystalline and thermal properties were studied by FT-IR, XRD and DSC. The mechanical properties and wettability of CS/PVA membranes were studied by tensile test and static contact angle measurement. In vitro biocompatibility was also evaluated by MTS cytotoxicity assay and SEM examination. The results suggest that adding PVA into CS membrane could greatly improve CS membrane's flexibility and wettability. All the membranes prepared were biocompatible and have potential applications in GTR technology.
Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, Key laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Zhejiang University, Hangzhou 310027, China.
Peng-Yu
PY
Zhuang
You-Liang
YL
Li
Li
L
Fan
Jun
J
Lin
Qiao-Ling
QL
Hu
D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013718:Tensile Strength; D017155:Wettability
D008567:Membranes, Artificial; D011142:Polyvinyl Alcohol; D048271:Chitosan