Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Ménière's disease.
OBJECTIVE
To verify the hypothesis that intratympanic (IT) gentamicin (Gent) treatment in Ménière's disease (MD) is capable of reducing endolymphatic hydrops (EH), as evaluated by 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) sequence in a 3-Tesla magnetic resonance imaging (MRI) unit, after IT gadolinium administration.


METHODS
A total of 8 patients (5 men and 3 women; aged 40-78 yr; median, 60 yr) with definite MD participated in the investigation. The duration of the disease ranged from 1 to 10 years (median, 4 yr), with a prevalence of vertigo spells of 1 to 6 per month (median, 3.1), as calculated in the last 6 months.


METHODS
A 3D-FLAIR MRI was performed 24 hours after IT injection of diluted gadobutrol. Intratympanic Gent injection was performed in a period variable from 1 to 3 weeks after 3D-FLAIR MRI. A single-shot administration protocol was attempted with additional injections administered on demand in the case of relapsing vertigo spells. MRI was repeated after 3 to 12 months (median, 8 mo) after treatment.


METHODS
The degree and extension of EH as evaluated by 3D-FLAIR MRI was compared from images obtained pre- and post-ITGent administration.


RESULTS
After ITGent administration, 4 patients did not show any MRI modification, 3 patients showed a worsening of EH in one site, and 1 patient showed a worsening in two sites. No subjects presented reduction of EH.


CONCLUSIONS
No evidence of reduced EH following ITGent treatment has been shown in the present imaging investigation.
Department of Otolaryngology, Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. franco.fiorino@virgilio.it
Francesco
F
Fiorino
Francesca B
FB
Pizzini
Franco
F
Barbieri
Alberto
A
Beltramello
D000328:Adult; D000368:Aged; D007758:Ear, Inner / Q000473:pathology; D018159:Endolymphatic Hydrops / Q000209:etiology / Q000473:pathology*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged
D005839:Gentamicins