Efect of periodontal disease and non surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients.
OBJECTIVE
The purpose of this study was to analyze how anti-infectious periodontal treatment affects C reactive protein (CRP) values in patients with type 1 diabetes, and correlate baseline CRP levels with periodontal disease severity.


METHODS
A cohort of fifty three subjects with type 1 diabetes and moderate to severe periodontitis were recruited. Periodontal parameters were measured, and blood samples were obtained to evaluate high-sensitivity C-reactive protein (hs-CRP). Group 1 was treated with scaling, root planning, and systemic administration of doxycycline. Group 2 received only scaling and root planning.


RESULTS
Hs-CRP was reduced after periodontal treatment in group 1 (-0.22 mg/l) and 2 (-0.21 mg/l ) but this reduction was not statistically significant, even in the patients with the best response to periodontal treatment. However, significant correlation appeared between hs-CRP and mean probing pocket depth (PPD) (p=0, 01) and mean clinical attachment level (CAL) (p=0,03).


CONCLUSIONS
Non-surgical periodontal treatment couldn' t reduce hs-CRP values, however, it was found an association between advanced periodontitis and elevated blood hs-CRP levels in patients with type 1 diabetes. It can be speculated that periodontal disease increases production of pro-inflammatory mediators in patients with type 1 diabetes, but other producing sources of these pro-inflammatory substances may exist.
University of Valencia, Spain.
Fernando
F
Llambés
Francisco-Javier
FJ
Silvestre
Antonio
A
Hernández-Mijares
Rami
R
Guiha
Daniel
D
Bautista
Raúl
R
Caffesse
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000097:blood* / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D012720:Severity of Illness Index; D016037:Single-Blind Method
D002097:C-Reactive Protein