Biological activity of Fe(III) aquo-complexes towards ferric chelate reductase (FCR).
In this study we have obtained experimental evidence that confirms the high activity of aquo complexes III and IV towards the enzyme FCR, responsible for the reduction of Fe(III) to Fe(II) in the process of iron acquisition by plants. The in vivo FCR assays in roots of stressed cucumber plants have shown a higher efficiency of the family of complexes III and a striking structure-activity relationship with the nature of the substituent placed in a phenyl group far away from the metal center. The results obtained in this work demonstrate that all the aquo compounds tested interact efficiently with the enzyme FCR and hence constitute a new concept of iron chelates that could be of great use in agronomy.
Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
Rosa
R
Escudero
Mar
M
Gómez-Gallego
Santiago
S
Romano
Israel
I
Fernández
Ángel
Á
Gutiérrez-Alonso
Miguel A
MA
Sierra
Sandra
S
López-Rayo
Paloma
P
Nadal
Juan J
JJ
Lucena
D038181:FMN Reductase / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D005290:Ferric Compounds; D008024:Ligands; D038181:FMN Reductase; C023903:ferric citrate iron reductase