Synthesis of 2-aminofurans and 2-unsubstituted furans via carbenoid-mediated [3 + 2] cycloaddition.
An efficient dual synthetic manifold for 2-aminofurans and 2-unsubstituted furans has been developed. The carbenoid-mediated [3 + 2] cycloaddition of copper carbenoids with enamines provides 2-amino-2,3-dihydrofurans which serve as common intermediates for both 2-aminofurans and 2-unsubstituted furans.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Yaojia
Y
Jiang
Vanessa Zhong Yue
VZ
Khong
Emmanuvel
E
Lourdusamy
Cheol-Min
CM
Park
D005663:Furans / Q000138:chemical synthesis*; D008722:Methods
D005663:Furans