No association between A actinomycetemcomitans or P gingivalis and chronic or aggressive periodontitis diagnosis.
OBJECTIVE
Only a few studies have attempted to detect differences in microbiologic profiles of patients with chronic periodontitis (CP) and aggressive periodontitis (AgP). The aim of this analysis was to assess if clinical diagnosis or other subject factors showed association with the presence of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in a cohort of periodontitis patients.


METHODS
Statistical analysis for association between bacterial detection and clinical diagnosis was performed on a total of 267 consecutive periodontitis cases diagnosed with either CP (n = 183) or AgP (n = 84). All subjects had microbiologic samples collected from the four deepest pockets and analyzed by nested polymerase chain reaction.


RESULTS
A actinomycetemcomitans was detected in 54% and 48% of CP and AgP subjects, respectively. A slightly higher detection of P gingivalis was found in CP (67% ) compared with AgP (52%) cases. The detection of P gingivalis was associated with older age (P = .002), less disease severity (P = .015), and IL6-1480 genotypes (P = .026), while A actinomycetemcomitans was associated with IL6-1480 genotypes (P = .001).


CONCLUSIONS
Detection of known periodontopathogenic bacteria is not able to discriminate different forms of periodontitis.
Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK. l.nibali@estman.ucl.ac.uk
Luigi
L
Nibali
Francesco
F
D'Aiuto
Derren
D
Ready
Mohamed
M
Parkar
Rusmizan
R
Yahaya
Nikos
N
Donos
D000189:Actinobacillus Infections / Q000175:diagnosis*; D000328:Adult; D000367:Age Factors; D016976:Aggregatibacter actinomycetemcomitans / Q000502:physiology*; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology*; D016301:Alveolar Bone Loss / Q000382:microbiology; D016866:Bacteroidaceae Infections / Q000175:diagnosis*; D055113:Chronic Periodontitis / Q000276:immunology / Q000382:microbiology*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D005889:Gingival Recession / Q000382:microbiology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000382:microbiology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D016966:Porphyromonas gingivalis / Q000502:physiology*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012907:Smoking
D015850:Interleukin-6