Inhibition of Streptococcus gordonii metabolic activity in biofilm by cranberry juice high-molecular-weight component.
Previous studies demonstrated that a cranberry high-molecular-mass, nondialyzable material (NDM) can inhibit adhesion of numerous species of bacteria and prevents bacterial coaggregation of bacterial pairs. Bacterial coaggregation leads to plaque formation leading to biofilm development on surfaces of oral cavity. In the present study, we evaluated the effect of low concentrations of NDM on Streptococcus gordonii metabolic activity and biofilm formation on restorative dental surfaces. We found that the NDM selectively inhibited metabolic activity of S. gordonii, without affecting bacterial viability. Inhibiting the metabolic activity of bacteria in biofilm may benefit the health of the oral cavity.
Department of Bioscience Research, The University of Tennessee, Memphis, TN 38163, USA.
Jegdish
J
Babu
Cohen
C
Blair
Shiloah
S
Jacob
Ofek
O
Itzhak
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D003764:Dental Materials; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D008970:Molecular Weight; D009055:Mouth / Q000382:microbiology*; D054773:Streptococcus gordonii / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D029799:Vaccinium macrocarpon / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D003764:Dental Materials