[Modulation of membrane blebbing and microparticle sheddimg as a target of cardiovascular prophylaxis].
Physicocemical and antigenic properties of peripheral blood lymphocytes and shed membrane microparticles were studied in patients with CHD and angina of effort and in those with hypertensive disease. The frequency of lymphocyte blebbing in CHD and angina patients was significantly higher than in those with HD (70.56, 52, 25.7% respectively). Incubation with rotenone and zymosan resulted in an increase of lymphocyte blebbing to 77.34 and 86.5% vs the initial level of 70.56% (p < 0.05). Patients of both groups had an increased number of membrane microparticles in peripheral blood (59.6 and 78.2 U/4 cm2 respectively). It is concluded that modulation of Imphocyte blebbing and microparticle shedding may be a promising target of cardiovascular prophylaxis.
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Inzhutova
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AA
Larionov
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OL
Lopatina
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000328:Adult; D002316:Cardiotonic Agents; D055252:Cell-Derived Microparticles / Q000276:immunology / Q000378:metabolism; D055808:Drug Discovery; D055354:Exosomes / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000517:prevention & control; D012402:Rotenone / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D014475:Uncoupling Agents / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology*
D002316:Cardiotonic Agents; D014475:Uncoupling Agents; D012402:Rotenone; D015054:Zymosan; D051997:ADP-ribosyl Cyclase 1