Review of recent studies on interventions for cognitive deficits in patients with cancer.
Research has demonstrated that patients with cancer experience cognitive deficits, often due to aggressive anticancer treatments. In this article, we critically review the interventional studies that have been conducted to investigate beneficial effects on cognitive function in cancer patients. Pharmacological agents that have been studied include psychostimulants, such as methylphenidate and modafinil, erythropoietin, and hormonal (supplement) treatments for patients who receive hormonal suppression therapy. In addition, several cognitive rehabilitation programs have been evaluated in cancer patients. Recently, the approach of physical exercise to treat cognitive deficits has received great interest, and findings from novel studies are keenly anticipated. Although, in general, the studies reviewed were well designed, future studies may wish to include larger sample sizes and pay more attention to the accurate assessment of cognitive function.
Tilburg University, Department of Medical Psychology and Neuropsychology, Center of Research on Psychology in Somatic Diseases, Prisma Building, 5000 LE, Tilburg, The Netherlands. k.gehring@uvt.nl
Karin
K
Gehring
Jan Anne
JA
Roukema
Margriet M
MM
Sitskoorn
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods; D003072:Cognition Disorders / Q000139:chemically induced* / Q000188:drug therapy* / Q000523:psychology; D020249:Hormone Replacement Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology / Q000628:therapy
D000970:Antineoplastic Agents; D000697:Central Nervous System Stimulants