Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B.
This aim of this study was to assess the potential role of IL-33 in the pathogenic process of chronic hepatitis B (CHB). The levels of serum IL-33 and soluble ST2 (sST2) in CHB patients and healthy controls (HC) were determined using enzyme-linked-immunosorbent serologic assay, and the Th1 (IFN-γ, TNF-α, IL-2) and Th2 (IL-4, IL-6, IL-10) cytokines by cytometric bead array. It was found that the levels of serum IL-33 in CHB patients were significantly higher than that of HC at the base line, but decreased after treatment with adefovir dipivoxil for 12 weeks. The levels of serum sST2, as a decoy receptor of IL-33, were significantly higher in CHB patients than the HC. There was no correlation between the levels of serum sST2 and IL-33. The concentrations of serum Th1 (IFN-γ, IL-2) and Th2 (IL-6, IL-10) cytokines in CHB patients significantly increased after treatment compared to the baseline. These results suggest that IL-33 is involved in the pathogenesis of CHB and that adefovir dipivoxil therapy can attenuate the production of IL-33 in patients with CHB.
Department of Central Laboratory, the Second Part of First Hospital, Jilin University, Changchun, China.
Juan
J
Wang
Yanjun
Y
Cai
Huifan
H
Ji
Junyan
J
Feng
Desalegn Admassu
DA
Ayana
Junqi
J
Niu
Yanfang
Y
Jiang
D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D056945:Hep G2 Cells; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use; D055815:Young Adult
D006514:Hepatitis B Surface Antigens; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins; D063065:Organophosphonates; D000225:Adenine; C106812:adefovir dipivoxil