Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome.
Adipocyte fatty acid-binding protein (A-FABP) links obesity and metabolic syndrome (MetS) and might be targeted in future therapies. Its utility as a MetS biomarker has been suggested in adults but has not been examined in children/adolescents. Our objectives were to identify metabolic parameters associated with A-FABP elevation in children and adolescents and to evaluate the effect of obesity intervention and A-FABP diagnostic utility. A-FABP and anthropometric, metabolic, and inflammatory indices were measured in 31 lean and 114 overweight/obese children and adolescents and reassessed after obesity intervention (1 year; diet and enhanced physical activity, with or without metformin). A-FABP was significantly higher in overweight/ obese than lean individuals, where it correlated with insulin, waist circumference (WC), and 2-h glucose independent of body mass index (BMI), age, gender, and developmental stage. The pattern of A-FABP associations differed between sexes. As a MetS indicator, A-FABP had 68% accuracy. The weight reduction program was effective in reducing A-FABP, BMI%, WC, triglycerides, and cholesterol. In conclusion, elevation in A-FABP is associated with MetS components independent of BMI status and can be reduced by diet and enhanced physical activity. A-FABP as a single MetS biomarker has a moderate accuracy.
Department of Medical Biochemistry, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland. krzystek@bioch.am.wroc.pl
Malgorzata
M
Krzystek-Korpacka
Eliza
E
Patryn
Iwona
I
Bednarz-Misa
Magdalena
M
Mierzchala
Katarzyna
K
Hotowy
Elzbieta
E
Czapinska
Irena
I
Kustrzeba-Wojcicka
Andrzej
A
Gamian
Anna
A
Noczynska
D017667:Adipocytes / Q000378:metabolism*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D004038:Diet, Reducing; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000178:diet therapy / Q000378:metabolism*; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D050177:Overweight / Q000178:diet therapy / Q000378:metabolism
D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins