Alcoholic ketoacidosis coincides with acute Marchiafava-Bignami disease.
Alcoholism is the major cause of electrolyte and acid-base imbalance and nutrition deficiency. Ketoacidosis is one of major advised effect on alcoholism. Marchiafava-Bignami disease, a rare alcohol-related disorder, characterized by altered mental status, seizure, and multifocal central nervous system signs, which results from progressive demyelination and necrosis of corpus callosum. Here, we presented a 53-year-old man presented as decreased conscious level and 4 extremity rigidity on admission. Alcoholic ketoacidosis coincided with acute Marchiafava-Bignami disease had been confirmed by biochemistry examination and cranial magnetic resonance imaging. Aggressive hydration with 5% dextrose in normal saline and intravenous vitamin B complex were administered. The patient's symptoms completely recovered after ketoacidosis has been corrected 2 days later.
Department of Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Ming-Hua
MH
Chen
Chun-An
CA
Cheng
D000208:Acute Disease; D000437:Alcoholism / Q000150:complications*; D001921:Brain / Q000473:pathology; D004636:Emergency Service, Hospital; D006801:Humans; D007662:Ketosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008875:Middle Aged