The serum level of interleukin-12 among patients with HCV infection.
The aim of investigation was to study cytokine-producing ability of blood immune cells in type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. 130 patients were investigated: 20 with acute hepatitis C; 38 with chronic hepatitis C; 72 with cirrhosis: among them 10 with Stage A, 14 with Stage B and 48 with Stage C. Also we used 30 healthy people as the controls. The study demonstrates significant changes of cytokine-producing ability of blood immune cells type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. The serum contents of IL-12 in chronic HCV patients is higher than in patients with acute HCV infection and in patients with liver cirrhosis The results showed that various types of acute, chronic viral hepatitis C and stages of cirrhosis were associated with misbalance in production of proinflammatory cytokine, i. e. a rise of interleukin-12 concentration versus the controls., which were the most prominent in cases of severe hepatic lesion.
Tbilisi State Medical Univesity, Department of Infectious Disease, Georgia.
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Mikadze
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Vashakidze
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D018664:Interleukin-12 / Q000097:blood*; D008099:Liver / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged
D018664:Interleukin-12