Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients.
Gallbladder carcinoma (GBC) is a malignancy with an extremely poor prognosis. In order to improve the survival rate, identification of new susceptibility risk factors is of importance. Here, we report findings on the novel cancer-related gene lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in exon 1 of allele *2. This study aimed to investigate the relationship of LAPTM4B allelic variation and GBC susceptibility. LAPTM4B genotype was analyzed in 155 healthy individuals and 91 GBC patients by PCR, and the genotypic distribution of LAPTM4B was analyzed with the chi-squared test. The frequency of allele *2 was 37.9 and 24.8% in the GBC and the control groups, respectively, representing a significant difference between these two groups (P<0.001). LAPTM4B allele *2 may be a risk factor associated with genetic susceptibility to GBC.
Department of Cell Biology, School of Basic Medical Sciences, Peking University, and Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing, China. yanghua@bjmu.edu.cn
Hua
H
Yang
Guojun
G
Zhai
Xiaoxu
X
Ji
Fuxia
F
Xiong
Jing
J
Su
Michael A
MA
McNutt
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D005706:Gallbladder Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic
C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins