Abnormal glucose regulation and gender-specific risk of fatal coronary artery disease in the HUNT 1 study.
OBJECTIVE
To assess fatal coronary artery disease (CAD) by gender and glucose regulation status.


METHODS
47,951 people were followed up according to fatal CAD identified in the National Cause of Death Registry. Gender-effects of fatal CAD in people with impaired glucose regulation (IGR), newly diagnosed diabetes (NDM) or known diabetes (KDM) compared with people with normal glucose regulation (NGR) were calculated using Cox regression.


RESULTS
Using NGR as reference, the hazard ratios (HR, 95% confidence intervals) associated with IGR was 1.2 (0.8-1.9) for women and 1.2 (0.9-1.6) for men. The corresponding HRs were 1.6 (1.2-2.2) and 1.4 (1.1.-1.9) for NDM, and 2.5 (2.1-2.8) and 1.8 (1.6-2.1) for KDM. The gender-difference in mortality varied by category (P(interaction) = 0.003). Using women as the reference, the HRs for men were 2.1 (2.0-2.3) for NGR, 1.8 (1.0-3.3) for IGR, 1.6 (1.0-2.5) for NDM, and 1.2 (1.0-1.5) for KDM.


CONCLUSIONS
Diabetes mellitus, but not IGR, was associated with fatal CAD in both genders. The known gender-difference in CAD mortality was attenuated in people with abnormal glucose regulation, evident already in people with IGR.
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Erik
E
Madssen
Lars
L
Vatten
Tom Ivar
TI
Nilsen
Kristian
K
Midthjell
Rune
R
Wiseth
Ane Cecilie
AC
Dale
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000378:metabolism / Q000401:mortality*; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment / Q000379:methods; D012737:Sex Factors
D001786:Blood Glucose