Palladium-catalyzed dehydrative heck olefination of secondary aryl alcohols in ionic liquids: towards a waste-free strategy for tandem synthesis of stilbenoids.
All in one: a tandem strategy has been developed wherein secondary aryl alcohols are directly coupled with aryl halides to provide stilbenoids through a dehydrative Heck sequence in the ionic liquid [hmim]Br, and with water as a by-product under microwave irradiation. Classical methods do not permit this sequence to proceed in one pot, and some methods require multiple steps. hmim=1-n-hexyl-3-methylimidazolium.
Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur, HP, India.
Rakesh
R
Kumar
Amit
A
Shard
Richa
R
Bharti
Yogesh
Y
Thopate
Arun Kumar
AK
Sinha