[The expression of MMP-2, -9 in the uterine leiomyoma and its significance in prognosis].
OBJECTIVE
To study on the expression and significance of MMP-2 and MMP-9 in the nasus epithelial carcinoma and their signification.


METHODS
Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasus tissue were detected for MMP-2 and 9 by immunohistochemistry technique (SP), and analysed their relationships between expression of MMP-and some clinical symptoms.


RESULTS
The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52.0% (26/50), which was significantly higher than those in the normal nasus tissue 28.0% (14/50), P < 0.05. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% (29/50), which was significantly higher than those in the normal nasus tissue 10.0% (5/50), P < 0.05.


CONCLUSIONS
It was suggested that there was a close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. The positive results of MMP-2, MMP-9 is partly valid for diagnosis of prognosis rate of MMP-2 and MMP-9 expression was high in nasus epithelial carcinoma tissues, MMP-2 and MMP-9 expression levels might be able to provide prognostic information.
Department of Otolaryngology, the Second Hospital Affiliated Xinjiang Medical University, Urumqi, 830063, China. zy91900@sina.com
Yan
Y
Zheng
Chunli
C
Wang
Jun
J
Ding
Shoushan
S
Jiao
Fengzhi
F
Si
Liming
L
Qu
Hui
H
Bao
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D011379:Prognosis; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9