Roles of transforming growth factor-β in graft-versus-host and graft-versus-tumor effects.
Transforming growth factor (TGF)-β is a pleiotropic cytokine with widespread and profound effects on immune cells. Consequently, it has generated considerable interest in relation to the immunologic outcomes after allogeneic hematopoietic cell transplantation. The TGF-β pathway has been shown to be an important modulator of alloimmunity, with direct consequences on graft-versus-host disease pathophysiology and graft-versus-tumor response. The TGF-β-related effects can be both beneficial and detrimental to the host, underscoring the complexity of TGF-β biology. This article reviews the evidence linking TGF-β to alloimmune responses in allogeneic hematopoietic cell transplantation and highlights foreseeable strategies that would maximize the beneficial effects of TGF-β pathway modulation on both graft-versus-host disease pathophysiology and the graft-versus-tumor effect.
Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada.
Cédric
C
Carli
Martin
M
Giroux
Jean-Sébastien
JS
Delisle
D000818:Animals; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control; D020350:Graft vs Tumor Effect / Q000187:drug effects / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D056747:Immunomodulation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D014184:Transplantation, Homologous
D016212:Transforming Growth Factor beta