Survivin SNP-carcinogen interactions in oral cancer.
In Taiwan, oral cancer is causally associated with environmental carcinogens. Survivin is an anti-apoptotic protein and is generally considered a marker of malignancy. The current study explored the combined effect of survivin gene polymorphisms and environmental carcinogens on the risk and clinico-pathological development of oral cancer. Five single-nucleotide polymorphisms (SNPs) of survivin genes from 439 male patients with oral cancer and 424 male control participants (who did not have cancer) were analyzed. The survivin -31GG, +9194 GG, and +9809 TT homozygotes exhibited higher risk for oral cancer compared with the corresponding ancestral genotype, after adjustment for related confounders. The survivin -31, +9194, and +9809 SNPs combined with betel quid chewing and/or tobacco consumption could robustly elevate susceptibility to oral cancer. The distribution frequency of the -31 G: +9194 A: +9809 T haplotype was significantly higher in oral cancer patients than in control participants. These results suggest that survivin gene polymorphisms and their interactions with environmental carcinogens may increase susceptibility to oral cancer in Taiwanese men.


BACKGROUND
AOR, adjusted odds ratio; CI, confidence intervals; PCR, polymerase chain-reaction; SNP, single-nucleotide polymorphisms.
Graduate Institute of Applied Science of Living, Tainan University of Technology, Yongkang District, Tainan City, Taiwan.
C J
CJ
Weng
Y H
YH
Hsieh
M K
MK
Chen
C M
CM
Tsai
C W
CW
Lin
S F
SF
Yang
D000225:Adenine; D000428:Alcohol Drinking / Q000009:adverse effects; D001114:Areca / Q000009:adverse effects; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D016022:Case-Control Studies; D003043:Cocarcinogenesis; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics*; D003596:Cytosine; D005787:Gene Frequency / Q000235:genetics; D059647:Gene-Environment Interaction; D005838:Genotype; D006147:Guanine; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D000077022:Survivin; D013624:Taiwan; D013941:Thymine
C107489:BIRC5 protein, human; D002274:Carcinogens, Environmental; D015853:Cysteine Proteinase Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D006147:Guanine; D003596:Cytosine; D000225:Adenine; D013941:Thymine