Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia.
Prenatal hypoxia is a common complication in pregnancy. We sought to determine whether resveratrol, a phytoalexin shown to improve health in several species, improves fetal outcomes associated with prenatal hypoxia in rats. Supplementation of maternal diets with resveratrol (4 g/kg diet) from gestational day (GD) 7 to GD21 almost completely reversed fetal demise in hypoxic (8.5% oxygen) pregnancies. We also show that resveratrol crosses the placenta, and may affect the fetus directly.
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.
S L
SL
Bourque
V W
VW
Dolinsky
J R B
JR
Dyck
S T
ST
Davidge
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol