POlish-Norwegian Study (PONS): research on chronic non-communicable diseases in European high risk countries - study design.
OBJECTIVE
A large-scale population study of health and disease would represent the most powerful tool to address these important issues in Poland. The aim is to extensively survey the study population with respect to important factors related to health and wellbeing, and subsequently, the intention is to follow-up the population for important health outcomes, including the incidence and mortality of cancer, cardiovascular disease, and other major causes of morbidity and mortality. The infrastructure for establishing a large cohort of people in Poland is needed; therefore, the PONS (Polish-Norwegian Study) project represents an eff ort to establish such infrastructure.


METHODS
The PONS Study is enrolling individuals aged 45-64 years. Structured lifestyle and food frequency questionnaires are administered. Study participants undergo medical check-up, anthropometric measurements and provide blood and urine sample for long-term storage. Fasting glucose and lipids profile are checked in the laboratory.


RESULTS
This report describes the design, justification and methodology of the presented prospective cohort study. Recruitment of participants began in September 2010, and by the end of 2011 it is planned to achieve a total of between 10,000 – 15,000 participants.


CONCLUSIONS
The PONS study is the fi rst prospective cohort study with blood and urine collection ever conducted in Central and Eastern Europe. It will provide reliable new data on both established and emerging risk factors for several major chronic diseases in a range of different circumstances.
Department of Cancer Epidemiology and Prevention, Maria Skłodowska-Curie Cancer Centre and Institute of Oncology, Warsaw, Poland. canepid@coi.waw.pl
Witold A
WA
Zatoński
Marta
M
Mańczuk
D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality; D002908:Chronic Disease / Q000453:epidemiology* / Q000401:mortality*; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality; D011044:Poland / Q000453:epidemiology; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D012424:Rural Population; D011795:Surveys and Questionnaires; D014505:Urban Population