Tolerability and efficacy of the intestinal phosphate binder Lantharenol® in cats.
BACKGROUND
Tolerability and efficacy of the intestinal phosphate binder Lantharenol® (lanthanum carbonate octahydrate) were tested in two prospective, randomized and negative controlled laboratory studies with healthy adult cats fed commercial maintenance diets non-restricted in phosphorus. In the first study, the maximal tolerated dose was determined. Starting from a dose of 0.125 g/kg body weight mixed with the daily feed ration, the dose of Lantharenol® was doubled every other week until signs of intolerability were observed (N=10 cats compared to 5 untreated controls). In the second study, the effects of feed supplementation for two weeks with approximately 2, 6, and 20% of the maximal tolerated dose on phosphorus excretion patterns and balance were assessed (N=8 cats per group).


RESULTS
Lantharenol® was found to be safe and well tolerated up to the dose of 1 g/kg bodyweight, corresponding to a concentration of 84 g Lantharenol®/kg complete feed, defined as dry matter with a standard moisture content of 12%. Feed supplementation for two weeks with approximately 2-20% of this dosage (i.e., 1.6, 4.8, and 16 g/kg complete feed) resulted in a shift from urinary to faecal phosphorus excretion. Apparent phosphorus digestibility was dose-dependently reduced compared to the control group fed with diet only (N=8).


CONCLUSIONS
The feed additive was well accepted and tolerated by all cats. Therefore, Lantharenol® presents a well tolerated and efficacious option to individually tailor restriction of dietary phosphorus as indicated, for instance, in feline chronic kidney disease.
Bayer Animal Health GmbH, Global Drug Discovery & Development, Building 6700, 51368 Leverkusen, Germany. Bernard.Schmidt@Bayer.com
Bernard H
BH
Schmidt
Ute
U
Dribusch
Peet C
PC
Delport
Jürgen M
JM
Gropp
F Josef
FJ
van der Staay
D000821:Animal Feed; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005503:Food Additives; D007811:Lanthanum / Q000009:adverse effects* / Q000627:therapeutic use*; D010758:Phosphorus / Q000097:blood* / Q000737:chemistry / Q000652:urine; D016226:Phosphorus, Dietary
D005503:Food Additives; D016226:Phosphorus, Dietary; D010758:Phosphorus; C119467:lanthanum carbonate; D007811:Lanthanum