Investigation of the inclusion complex of β-cyclodextrin with mycophenolate mofetil.
The acid-base equilibrium of mycophenolate mofetil is studied in the absence and presence of β-cyclodextrin (β-CD). The conditional acidity constants are obtained by rank annihilation factor analysis (RAFA) as a function of β-CD concentrations. Also the stability constants for inclusion complexes of β-CD with both acidic and basic forms are calculated. The conditional acidity constant decreases by increasing β-CD concentration. The calculated stability constants show that the acidic form of mycophenolate mofetil forms more stable inclusion complex (552±7 M(-1)) than its basic anionic form (158±2 M(-1)).
Department of Chemistry, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran. l_khalafi@yahoo.com
Lida
L
Khalafi
Mohammad
M
Rafiee
Fatemeh
F
Mahdiun
Sajjad
S
Sedaghat
D000136:Acid-Base Equilibrium; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*
D047392:beta-Cyclodextrins; D009173:Mycophenolic Acid