Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men.
Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40 years; BMI: 20-26 kg/m(2)) were intravenously infused lactate and saline, respectively, for 105 min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75 min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25 h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.
Interdisciplinary Obesity Center, Cantonal Hospital St. Gallen, Heidener Strasse 11, CH-9400 Rorschach, Switzerland. bernd.schultes@kssg.ch
Bernd
B
Schultes
Sebastian M
SM
Schmid
Britta
B
Wilms
Kamila
K
Jauch-Chara
Kerstin M
KM
Oltmanns
Manfred
M
Hallschmid
D000328:Adult; D000855:Anorexia / Q000209:etiology*; D001066:Appetite / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D007003:Hypoglycemia; D007328:Insulin / Q000008:administration & dosage; D019344:Lactic Acid / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D055815:Young Adult
D007328:Insulin; D019344:Lactic Acid