Synthesis of cyclic peptides and cyclic proteins via ligation of peptide hydrazides.
Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower costs.
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P.R. China.
Ji-Shen
JS
Zheng
Shan
S
Tang
Ye
Y
Guo
Hao-Nan
HN
Chang
Lei
L
Liu
D003500:Cyclization; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry
D006834:Hydrazines; D009842:Oligopeptides; D010456:Peptides, Cyclic; D011506:Proteins