The path forward to biomarker discovery in psoriatic disease: a report from the GRAPPA 2010 annual meeting.
At the 2010 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), wide-ranging discussions were held regarding biomarker research in psoriatic disease. Consensus was reached on 2 areas of priority: (1) the study of soluble biomarkers of radiographic progression in psoriatic arthritis (PsA); and (2) the analysis of comorbidity biomarkers, specifically cardiovascular and articular, in a psoriasis inception cohort. For each of these areas, rigorous definition of the clinical phenotype of PsA will be essential. To date, 2 instruments have been identified to define the phenotype: the ClASsification of Psoriatic ARthritis criteria and various screening questionnaires. In this overview, we discuss the challenges of the clinical phenotype of PsA and review GRAPPA plans for developing a research program for biomarker discovery.
University of Toronto and Toronto Western Research Institute, Toronto, Ontario, Canada. dafna.gladman@utoronto.ca
Dafna D
DD
Gladman
Christopher T
CT
Ritchlin
Oliver
O
Fitzgerald
D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D011795:Surveys and Questionnaires
D015415:Biomarkers