Auto-associative amphiphilic polysaccharides as drug delivery systems.
Self-assembly of amphiphilic polysaccharides provides a positive outlook for drug delivery systems without the need for solvents or surfactants. Various polymeric amphiphilic polysaccharides undergo intramolecular or intermolecular associations in water. This type of association, promoted by hydrophobic segments, led to the formation of various drug delivery systems such as micelles, nanoparticles, liposomes and hydrogels. Here, we review a selection of the most important amphiphilic polysaccharides used as drug delivery systems and their pharmaceutical applications. Attention focuses on amphiphilic chitosan owing to its unique properties such as excellent biocompatibility, non-toxicity and antimicrobial and bioadhesive properties.
UMR CNRS Physico-chemistry, Pharmacotechny and Biopharmacy, Université Paris-Sud, School of Pharmacy, Châtenay Malabry, France.
Leila N
LN
Hassani
Frédéric
F
Hendra
Kawthar
K
Bouchemal
D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D016503:Drug Delivery Systems; D020100:Hydrogels; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D062346:Molecular Medicine; D015394:Molecular Structure; D053758:Nanoparticles; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
D001672:Biocompatible Materials; D004337:Drug Carriers; D020100:Hydrogels; D008823:Micelles; D011134:Polysaccharides; D048271:Chitosan