Methotrexate toxicity presenting as ulcerated psoriatic plaques.
Methotrexate toxicity is known to cause erosions of existing psoriatic plaques, although rare. We describe two patients who developed painful ulcerated psoriatic plaques as an early presenting sign of methotrexate toxicity and review the risk factors associated with this manifestation.
Dermatology Unit, Department of Medicine, University Malaya, Kuala Lumpur, Malaysia. suming1@yahoo.com
Su-ming
SM
Wong
Yew Thong
YT
Chong
Suganthi
S
Thevarajah
Roshidah
R
Baba
D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced* / Q000175:diagnosis; D012307:Risk Factors; D012883:Skin Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D060726:Torso
D003879:Dermatologic Agents; D008727:Methotrexate