Can serum gamma-glutamyltransferase levels be useful at diagnosing gestational diabetes mellitus?
OBJECTIVE
The aim of this study was to evaluate plasma gamma-glutamyltransferase (GGT) in gestational diabetes mellitus (GDM) in pregnant women at oral glucose tolerance test (OGTT) and the diagnosis of GDM and to explore whether this activity is associated with metabolic parameters.


METHODS
This prospective control study included 37 women with GDM and 42 women with normal glucose tolerance in pregnancy (control group). In the study group (GDM), blood was taken for analyzing 100 g OGTT from women who have abnormal 50 g glucose challenge test (GCT).


RESULTS
Compared with the controls, the GDM group had significantly higher mean values for serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), triglyceride and GGT. Within the GDM group, GGT levels were only negatively correlated with high-density lipoprotein (r = -0.41, p = 0.01). GGT was determined to be an independent metabolic parameter for GDM. While performing analyses receiver operational curve analysis, GGT cutoff set was set at 16 IU/L, the sensitivity was calculated as 86%, and specificity was as 37%.


CONCLUSIONS
The increase at GGT level is an independent risk factor for GDM and identified as high-risk women for diagnosis of GDM.
Department of Obstetrics and Gynecology, Gulhane Military Medical Faculty, Etlik, Ankara, Turkey.
Ibrahim
I
Alanbay
Hakan
H
Coksuer
Mutlu
M
Ercan
Ugur
U
Keskin
Emre
E
Karasahin
Mustafa
M
Ozturk
Serkan
S
Tapan
Ozlem
O
Ozturk
Ismail
I
Kurt
Ali
A
Ergun
D000328:Adult; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000201:enzymology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D011247:Pregnancy; D012372:ROC Curve; D012680:Sensitivity and Specificity; D005723:gamma-Glutamyltransferase / Q000097:blood*
D008055:Lipids; D005723:gamma-Glutamyltransferase