Susceptibilities to amphotericin B, fluconazole and voriconazole of Trichosporon clinical isolates.
A total of 35 Trichosporon isolates were collected from the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) project from 1999 to 2006, and their identifications as well as drug susceptibilities were determined. The most frequently isolated species was T. asahii (62.9%), and the most common clinical sample that yielded Trichosporon isolates was urine (37.1%). The etiology of all seven invasive trichosporonosis was T. asahii. For the 22 T. asahii isolates, the MIC(50) and MIC(90) for amphotericin B were 0.25 and 1 μg/mL, respectively. Those for fluconazole were 2 and 4 μg/mL, respectively, and for voriconazole 0.031 and 0.063 μg/mL, respectively. When the intraclass correlation coefficients (ICCs) and agreements were calculated, we found that the MICs of fluconazole obtained from different methods were similar and the inter-method discrepancies were low. Nevertheless, no unanimous MIC of amphotericin B and voriconazole was obtained among different methods.
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan.
Moan Shane
MS
Tsai
Yun Liang
YL
Yang
An Huei
AH
Wang
Lih Shinn
LS
Wang
Daniel C T
DC
Lu
Ci Hong
CH
Liou
Li Yun
LY
Hsieh
Chi Jung
CJ
Wu
Ming Fang
MF
Cheng
Zhi Yuan
ZY
Shi
Hsiu Jung
HJ
Lo
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011743:Pyrimidines / Q000494:pharmacology*; D013624:Taiwan; D014230:Triazoles / Q000494:pharmacology*; D014250:Trichosporon / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D060586:Trichosporonosis / Q000382:microbiology*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D015725:Fluconazole; D065819:Voriconazole