Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
In this issue of Molecular Cell, Day et al. (2012) reveal a surprising benefit of peroxiredoxin inactivation at high H(2)O(2), showing that in Schizosaccharomyces pombe turning off peroxide defenses preserves the pool of reduced thioredoxin for repairing proteins vital to survival.
Department of Biochemistry and Biophysics, Oregon State University, 2011 Ag Life Sciences Building, Corvallis, OR 97331, USA.
P Andrew
PA
Karplus
Leslie B
LB
Poole
D006861:Hydrogen Peroxide / Q000494:pharmacology*; D054464:Peroxiredoxins / Q000037:antagonists & inhibitors*; D012568:Schizosaccharomyces / Q000201:enzymology*; D029702:Schizosaccharomyces pombe Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism*
D029702:Schizosaccharomyces pombe Proteins; C515985:Tpx1 protein, S pombe; C532961:Trx1 protein, S pombe; D013879:Thioredoxins; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins