Osteophilic multilayer coatings for accelerated bone tissue growth.
Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.
Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139 USA.
Nisarg J
NJ
Shah
Jinkee
J
Hong
Md Nasim
MN
Hyder
Paula T
PT
Hammond
D001846:Bone Development; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011108:Polymers; D011994:Recombinant Proteins; D048271:Chitosan; D017886:Durapatite