Relation of blood cadmium, lead, and mercury levels to biomarkers of lipid peroxidation in premenopausal women.
Exposures to cadmium, lead, and mercury are associated with adverse health effects, including cardiovascular disease, which may be promoted by lipid peroxidation. The authors examined cadmium, lead, and mercury in relation to plasma levels of F(2)-8α isoprostanes (isoprostane), 9-hydroperoxy-10,12-octadecadienoic acid (9-HODE), 13-hydroxy-9,11-octadecadienoic acid (13-HODE), and thiobarbituric acid reactive substances (TBARS) in 252 women from western New York State (2005-2007). Healthy premenopausal women were followed for ≤2 menstrual cycles, with biomarkers of lipid peroxidation being assessed ≤8 times per cycle. Metals were measured at baseline in whole blood. Linear mixed models were used to estimate the association between cadmium, lead, and mercury and lipid peroxidation biomarkers. Median cadmium, lead, and mercury levels were 0.30 μg/L, 0.86 μg/dL, and 1.10 μg/L, respectively. Blood cadmium, lead, and mercury were not associated with increases in isoprostane, TBARS, 9-HODE, or 13-HODE levels. Isoprostane levels decreased 6.80% (95% confidence interval: -10.40, -3.20) per 1% increase in mercury. However, after adjustment for a simulated strong confounding factor, such as precisely measured fish consumption, the observed association was attenuated, suggesting that this unexpected association could be attributable to unmeasured confounding. In this population of healthy premenopausal women with low exposure levels, cadmium, lead, and mercury were not associated with elevated lipid peroxidation biomarkers.
Epidemiology Branch, Division of Epidemiology, Statistics, and PreventionResearch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd., Rockville, MD 20852, USA.
Anna Z
AZ
Pollack
Enrique F
EF
Schisterman
Lynn R
LR
Goldman
Sunni L
SL
Mumford
Neil J
NJ
Perkins
Michael S
MS
Bloom
Carole B
CB
Rudra
Richard W
RW
Browne
Jean
J
Wactawski-Wende
D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002104:Cadmium / Q000009:adverse effects / Q000097:blood*; D004032:Diet; D005260:Female; D005399:Fishes; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D007854:Lead / Q000009:adverse effects / Q000097:blood*; D016014:Linear Models; D008041:Linoleic Acids / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008597:Menstrual Cycle / Q000097:blood; D008628:Mercury / Q000009:adverse effects / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D055815:Young Adult
D015415:Biomarkers; D028421:Isoprostanes; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium; C024347:9-hydroxy-10,12-octadecadienoic acid; D007854:Lead; C024348:13-hydroxy-9,11-octadecadienoic acid; D008628:Mercury