Epidemiology and potential pathomechanisms of cardiovascular comorbidities in psoriasis: a report from the GRAPPA 2010 annual meeting.
There is increasing awareness that psoriasis is more than "skin deep." Several recent reviews focused on biomarkers have indicated the systemic dimension of psoriasis and the comorbidity that psoriasis shares with other chronic inflammatory diseases. Of emerging significance is the relationship to cardiovascular disease, which contributes substantially to patients' increased mortality. This article examines currently available evidence favoring the concept of a causal link between psoriasis and cardiovascular disease, and summarizes a report represented at the 2010 Annual Meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis).
Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. boehncke@em.uni-frankfurt.de
Wolf-Henning
WH
Boehncke
D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D002908:Chronic Disease; D015897:Comorbidity; D042783:Endothelial Cells / Q000502:physiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D011565:Psoriasis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D012720:Severity of Illness Index
D015415:Biomarkers