[Inhalation of hypertonic saline: a promising therapy in bronchiectasis].
BACKGROUND
Accumulation of mucus into the lungs in bronchiectasis lowers the patients' quality of life. Hypertonic aerosols stimulate the removal of mucus.


METHODS
37 bronchiectasis patients without cystic fibrosis inhaled 4 ml of a 6 per cent saline solution twice a day for three months. Amount of coughs, PEF values and oxygen saturation associated with the first inhalation were measured. Quality of life was assessed by the SGRQ (St George's Respiratory Questionnaire).


RESULTS
Inhalation did not decrease oxygen saturation but did lower slightly the PEF value. SGRQ score decreased by 9.2 points on the average (p = 0.002) indicating clinically significant improvement in quality of life.


CONCLUSIONS
Hypertonic saline inhalations in patients with brochiectasis are safe and may also improve quality of life.
Kuopion Yliopistollinen Sairaala, Keuhkosairauksien Klinikka.
Heikki
H
Koskela
Minna
M
Purokivi
D000280:Administration, Inhalation; D000336:Aerosols; D001987:Bronchiectasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009079:Mucociliary Clearance; D011788:Quality of Life; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D000336:Aerosols; D012462:Saline Solution, Hypertonic