Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases.
Nanoparticles containing stable holmium ((165) Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield (166) Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the (166) Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.
Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anthony J
AJ
Di Pasqua
James E
JE
Huckle
Jin-Ki
JK
Kim
Younjee
Y
Chung
Andrew Z
AZ
Wang
Michael
M
Jay
Xiuling
X
Lu
D000818:Animals; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D006695:Holmium / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D009502:Neutrons; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D023041:Xenograft Model Antitumor Assays
D004337:Drug Carriers; D006695:Holmium