Rats, salt, and history.
The Dahl salt-sensitive rat is a 50-year-old enigma in hypertension research. How does salt increase blood pressure? One hypothesis put forward is the involvement of reactive oxygen species produced in the renal outer medulla. A novel rat gene-deletion model in this issue of Cell Metabolism supports this argument.
Experimental and Clinical Research Center, Charité Medical Faculty and Max-Delbrück Center for Molecular Medicine, 13125 Berlin, Germany. luft@charite.de
Friedrich C
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Luft