Rh-catalyzed intramolecular sp2 C-H bond difluoromethylenation.
A new Rh-catalyzed intramolecular coupling reaction of a CF(2)Br group with a 2-aryl of indole or pyrrole via C-H bond activation is presented. This reaction represents a new way of incorporating difluoromethylene groups into organic compounds. Preliminary mechanistic studies suggest that this reaction might not occur via a conventional free radical pathway.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Yajun
Y
Li
Jiangtao
J
Zhu
Haibo
H
Xie
Shan
S
Li
Dongjie
D
Peng
Zhengke
Z
Li
Yongming
Y
Wu
Yuefa
Y
Gong
D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008745:Methylation; D012238:Rhodium / Q000737:chemistry*
D006845:Hydrocarbons, Fluorinated; D012238:Rhodium