An intraoperative multimodal neurophysiologic approach to successful resection of precentral gyrus epileptogenic lesions.
Cortical dysplasias (CDs) are highly epileptogenic lesions with a good prognosis of seizure freedom, if totally resected. However, their accurate delineation and resection can be difficult, and depend on the extent of pathology and lesion location. Intraoperative neurophysiologic assessments are valuable in these situations. We present an illustrative case of intractable epilepsy where judicious use of intraoperative neurophysiologic-techniques guided resection of precentral CD, under general anesthesia and in the absence of preoperative electrophysiologic mapping data. Ictal onset was accurately delineated using electrocorticography (ECoG). Phase reversal of the median somatosensory-evoked potentials (MSSEPs) localized the central sulcus (CS). Motor evoked potentials (MEPs) triggered by high-frequency monopolar anodal electrical cortical stimulation at the primary motor cortex (PMC) threshold delineated the PMC. Using this technique, PMC and the corticospinal tract (CST) were continuously monitored during resection. No changes in MEPs from the preresection baseline were seen; no residual abnormal activity was present in the postresection ECoG. The patient emerged from surgery without deficits and has been seizure free during a 10-month follow-up. Staged multimodal intraoperative neurophysiology can be used successfully under general anesthesia to guide resection of epileptogenic lesions within the precentral gyrus, as an add-on or, in certain situations, as a viable alternative to preoperative electrophysiologic mapping.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02214, USA. mvsimon@partners.org
Mirela V
MV
Simon
Andrew J
AJ
Cole
Eric C
EC
Chang
Bradley R
BR
Buchbinder
Steve M
SM
Stufflebeam
Ala
A
Nozari
Anat O
AO
Stemmer-Rachamimov
Emad N
EN
Eskandar
D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography; D004576:Electromyography; D004827:Epilepsy / Q000175:diagnosis* / Q000601:surgery*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D011712:Pyramidal Tracts / Q000098:blood supply / Q000503:physiopathology
D010100:Oxygen