[Radiobiology dedicated to endothelium].
Radiotherapy is used in more than 60% of the curative or palliative intent treatment against cancer. However, its effectiveness is often limited by intrinsic resistance of cancer cells and the radiation toxicity of the surrounding normal tissue. New paradigms in oncology are not only focused on tumor cells, but also considered non-transformed from the stromal cells as potential therapeutic target. Among the different cell types, endothelial cells play a singular role, due by their presence, in the vast majority of tumors but also of healthy tissue. This review proposes to participate in the understanding of the response of the endothelium, in the radiation sensitivity of tumor and healthy tissue after radiotherapy.
Inserm UMR892, centre de recherche en cancérologie Nantes-Angers, 8, quai Moncousu, 44007 Nantes cedex 01, France.
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Supiot
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Paris
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017209:Apoptosis; D042783:Endothelial Cells / Q000473:pathology / Q000528:radiation effects*; D004730:Endothelium, Vascular / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000532:radiotherapy; D011879:Radiotherapy Dosage
D020533:Angiogenesis Inhibitors