Clinical activity and cardiac tolerability  of non-pegylated liposomal doxorubicin in breast cancer: a synthetic review.
Anthracycline-containing regimens have demonstrated significant disease-free and overall survival benefits in the adjuvant setting and also provide palliative benefit in metastatic disease. . Over the past two decades, an increasing proportion of patients have been exposed to adjuvant anthracyclines with concomitant reduction in their use for palliation, as a result of concerns regarding efficacy and cumulative anthracycline-associated cardiotoxicity, as well as the availability of other systemic chemotherapeutic options. This report reflects the consensus view of a meeting of oncologists, pharmacologists and cardiologists held in Florence, Italy, on April 30, 2010. The objectives of the meeting were to review the role and limits of conventional anthracyclines in the treatment of breast cancer, to provide recommendations for the use of novel anthracycline formulations, such as non-pegylated liposomal doxorubicin (NPLD), and to identify potential future indications for NPLD that warrant further research.
SC Oncologia Medica 2, Presidio Ospedaliero San Giovanni Antica Sede, Turin, Italy.
Mario
M
Airoldi
Dino
D
Amadori
Sandro
S
Barni
Saverio
S
Cinieri
Sabino
S
De Placido
Angelo
A
Di Leo
Alessandra
A
Gennari
Stefano
S
Iacobelli
Maria Teresa
MT
Ionta
Vito
V
Lorusso
Marzia
M
Lotrionte
Paolo
P
Marchetti
Rodolfo
R
Mattioli
Giorgio
G
Minotti
Paolo
P
Pronzato
Giovanni
G
Rosti
Carlo Alberto
CA
Tondini
Andrea
A
Veronesi
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D008081:Liposomes; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D004317:Doxorubicin