Synthetic biology and the development of tools for metabolic engineering.
Synthetic biology can significantly advance metabolic engineering by contributing tools (minimal hosts, vectors, genetic controllers, characterized enzymes). The development of these tools significantly reduced the costs and time to develop the antimalarial drug artemisinin, but the availability of more tools could have reduced these costs substantially.
Synthetic Biology Engineering Research Center, University of California, Berkeley, CA 94720, USA. keasling@berkeley.edu
Jay D
JD
Keasling
D000962:Antimalarials / Q000138:chemical synthesis / Q000191:economics / Q000378:metabolism; D037621:Artemisinins / Q000138:chemical synthesis / Q000191:economics / Q000378:metabolism; D015195:Drug Design; D007783:Lactones / Q000138:chemical synthesis / Q000191:economics / Q000378:metabolism; D060847:Metabolic Engineering / Q000191:economics / Q000379:methods* / Q000639:trends; D058615:Synthetic Biology / Q000191:economics / Q000379:methods* / Q000639:trends
D000962:Antimalarials; D037621:Artemisinins; D007783:Lactones; C075875:artemisin