Successful pregnancy after treatment of a cervical gestational trophoblastic neoplasia: a case report.
BACKGROUND
Primary gestational trophoblastic neoplasia of the uterine cervix is exceptionally rare, with fewer than 100 cases reported worldwide.


METHODS
A 33-year-old, gravida 1, para 1, Filipino woman was admitted due to vaginal bleeding nearly 7 months after delivery of a full-term, stillborn infant. Transvaginal ultrasound revealed a heterogeneous, predominantly solid, vascular mass at the upper half of the cervix measuring 3.05 x 3.75 x 3.6 cm. Serum beta human chorionic gonadotropin (beta-hCG) on admission was 101,922.5 mIU/mL. She was initially treated with single-agent chemotherapy in the form of methotrexate. Rising levels of serum beta-hCG after the third cycle necessitated a shift to multiagent chemotherapy in the form of etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. The patient achieved remission after 6 cycles and eventually achieved a successful pregnancy.


CONCLUSIONS
Primary gestational trophoblastic neoplasia of the cervix can be treated successfully using chemotherapy.
Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines, Manila. jayannechuamd@yahoo.com
Angelica A
AA
Chua
Agnes L
AL
Soriano-Estrella
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage; D011247:Pregnancy; D011256:Pregnancy Outcome; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology
D016595:Misoprostol