Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study.
BACKGROUND
Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients.


METHODS
Eighteen TRD patients, 17 TSD patients and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans.


RESULTS
There are widespread differences in ALFF values among TRD patients, TSD patients and healthy subjects throughout the cerebellum, the visual recognition circuit (middle temporal gyrus, middle/inferior occipital gyrus and fusiform), the hate circuit (putamen), the default circuit (ACC and medial frontal gyrus) and the risk/action circuit (inferior frontal gyrus). The differences in brain circuits between the TRD and TSD patients are mainly in the cerebellum, the visual recognition circuit and the default circuit.


CONCLUSIONS
The affected brain circuits of TRD patients might be partly different from those of TSD patients.
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Wen-bin
WB
Guo
Feng
F
Liu
Zhi-min
ZM
Xue
Xi-jia
XJ
Xu
Ren-rong
RR
Wu
Chao-qiong
CQ
Ma
Sarah C
SC
Wooderson
Chang-lian
CL
Tan
Xue-li
XL
Sun
Jin-dong
JD
Chen
Zhe-ning
ZN
Liu
Chang-qing
CQ
Xiao
Hua-fu
HF
Chen
Jing-ping
JP
Zhao
D000328:Adult; D002531:Cerebellum / Q000502:physiology*; D003863:Depression / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D016896:Treatment Outcome; D055815:Young Adult