Sub-clinical hypothyroidism in infertile Nigerian women with hyperprolactinaemia.
Studies on the impact of subclinical hypothyroidism in infertility are scarce and this seeks to determine the proportion of infertile Nigerian women with hyperprolactinaemia that had subclinical hypothyroidism. Serum prolactin and thyroid stimulating hormone were determined using ELECSYS 1010 auto analyzer. Two hundred infertile women were evaluated and 67(33.7%) had hyperprolactinaemia. Subclinical hypothyroidism was observed in 14.9% of women with hyperprolactinaemia, 4.5% and 10.5% of women with primary and secondary infertility, while hyperprolactinaemia was observed in 29.9% and 70.1% in primary and secondary infertility respectively. Mean levels of thyroid stimulating hormone and prolactin were higher in secondary infertility than primary infertility. Subclinical hypothyroidism and hyperprolactinaemia were higher in secondary infertility than primary infertility. The ratio of proportions between hypothyroidism and hyperprolactinaemia was 1:7.
Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin city, Nigeria. biodunemokpae@yahoo.com
M A
MA
Emokpae
H B
HB
Osadolor
A
A
Omole Ohonsi
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005298:Fertility; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D007247:Infertility, Female / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D009549:Nigeria / Q000453:epidemiology; D011388:Prolactin / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood
D015415:Biomarkers; D011388:Prolactin; D013972:Thyrotropin