Clinical translation of stem cells in neurodegenerative disorders.
Stem cells and their derivatives show tremendous potential for treating many disorders, including neurodegenerative diseases. We discuss here the challenges and potential for the translation of stem-cell-based approaches into treatments for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden. olle.lindvall@med.lu.se
Olle
O
Lindvall
Roger A
RA
Barker
Oliver
O
Brüstle
Ole
O
Isacson
Clive N
CN
Svendsen
D000818:Animals; D002986:Clinical Trials as Topic; D004298:Dopamine / Q000378:metabolism; D019317:Evidence-Based Medicine; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D057170:Translational Research, Biomedical
D004298:Dopamine