A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction.
A straightforward and atom-economical base-free palladium-catalyzed regioselective direct arylation of coumarins and chromenones is devised. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and allows construction of various biologically important flavone and neoflavone backbones.
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 14176, Tehran, Iran.
Mehdi
M
Khoobi
Masoumeh
M
Alipour
Samaneh
S
Zarei
Farnaz
F
Jafarpour
Abbas
A
Shafiee
D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D003374:Coumarins; D047309:Flavones; D010165:Palladium