[Efficacy observation of combination of Lumbrukinase Capsule and Probucol Tablet in treating cerebral infarction patients' unstable atheromatous plaque of the carotid artery].
OBJECTIVE
To observe the effects of combination of Lumbrukinase Capsule (LC) and Probucol Tablet (PT) in treating cerebral infarction (CI) patients' unstable atheromatous plaque of the carotid artery.


METHODS
150 patients were randomly assigned to the PT group and the LC group, 75 cases in each. Patients in the PT group took 0.5 g PT each time, twice daily. On the basis of PT, patients in the LC group also took 600 thousand U LC, thrice daily. The treatment course was 12 months for all. The serum levels of TC, TG, HDL-C, LDL-C, fibrinogen (FIB), and changes of the carotid atherosclerotic plaque were measured before treatment, 6 and 12 months after treatment. Meanwhile, adverse events were recorded.


RESULTS
The serum levels of TC, TG, and LDL-C were all lower 6 months after treatment than before treatment in the two groups, showing statistical significance (P < 0.05). The serum level of HDL-C was higher 6 months after treatment than before treatment in the two groups, showing no statistical significance (P > 0.05). When compared with before treatment in the same group, the serum level of FIB significantly decreased after treatment. Besides, there was statistical difference between the two groups (P < 0.05). There was no statistical difference in the serum levels of blood lipids or FIB between 12-month treatment and 6-month treatment in the same group (P > 0.05). The plaque effective rate in the LC group was superior to that of the PT group, showing statistical significance (P < 0.01). During the treatment period, the occurrence of cerebrovascular event was lower in the LC group than in the PT group (P < 0.05). Partial patients in the two groups had gastric discomfort.


CONCLUSIONS
The combination of LC and PT could prevent and treat arteriosclerosis, stabilize the plaque, effectively lower the occurrence of ischemic events. Its clinical application did not increase the risk of hemorrhage. It was safe and effective, worthy of spreading. It was necessary to further observe whether combination of LC and PT could increase side effects of the digestive tract.
Department of Neurology, Wuhan Hospital of Integrative Medicine, Yuhan (430022).
Xiao-feng
XF
Pan
Wei
W
Shao
Guo-hua
GH
Chen
D000328:Adult; D000368:Aged; D000818:Animals; D001688:Biological Products / Q000627:therapeutic use; D002340:Carotid Artery Diseases / Q000188:drug therapy; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D008875:Middle Aged; D009835:Oligochaeta / Q000201:enzymology; D058226:Plaque, Atherosclerotic / Q000188:drug therapy*; D011341:Probucol / Q000627:therapeutic use*; D012697:Serine Endopeptidases / Q000627:therapeutic use*; D016896:Treatment Outcome
D001688:Biological Products; D008419:Materia Medica; D012697:Serine Endopeptidases; D011341:Probucol