Concept for a gas-cell-driven drug delivery system for therapeutic applications.
This paper presents a concept for an implantable micro-pump based on hydrogen-generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 microl/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.
TU München, Heinz Nixdorf Lehrstuhl für Medizinische Elektronik, München, Germany. sven.becker@tum.de
S
S
Becker
T
T
Xu
F
F
Ilchmann
J
J
Eisler
B
B
Wolf
D003920:Diabetes Mellitus / Q000628:therapy; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004358:Drug Therapy / Q000379:methods; D011211:Electric Power Supplies; D055664:Electrochemical Techniques / Q000379:methods; D004867:Equipment Design / Q000295:instrumentation*; D004869:Equipment Safety; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D015918:Infusion Pumps, Implantable; D059408:Pain Management / Q000379:methods; D011312:Pressure
D006859:Hydrogen