Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.
Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.
Laboratoire de Pharmacognosie Associé au CNRS UMR 8076 BioCIS, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud, 5 Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.
Gerardo
G
Cebrián-Torrejón
Suzana
S
Assad Kahn
Nathalie
N
Lagarde
Flavia
F
Castellano
Karine
K
Leblanc
Jordi
J
Rodrigo
Valérie
V
Molinier-Frenkel
Antonieta
A
Rojas de Arias
Maria Elena
ME
Ferreira
Cécile
C
Thirant
Alain
A
Fournet
Bruno
B
Figadère
Hervé
H
Chneiweiss
Erwan
E
Poupon
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000187:drug effects; D015394:Molecular Structure; D058953:Neural Stem Cells / Q000187:drug effects*; D010239:Paraguay; D024301:Plant Bark / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism; D032106:Zanthoxylum / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D011753:Pyrones; C571470:trans-avicennol; D020929:Mitogen-Activated Protein Kinase Kinases