The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy.
It is well established that the altered metabolism exhibited by cancer cells, including high rates of glycolysis, lactate production, and biosynthesis of lipids, nucleotides, and other macromolecules, and which may occur either as a consequence or as a cause of tumorigenesis, plays an essential role in cancer progression. Recently, the tumor suppressor p53 was found to play a central role in this process. Here, we review the role of p53 in modulating tumor metabolism. Specifically, we focus on the functions of p53 in regulating aerobic glycolysis, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis and oxidation, and glutamine metabolism, and we discuss the therapeutic strategy whereby p53 helps to prevent malignant progression.
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, The People's Republic of China.
Lan
L
Shen
Xiang
X
Sun
Zhenhong
Z
Fu
Guodong
G
Yang
Jianying
J
Li
Libo
L
Yao
D000581:Amidohydrolases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D016158:Genes, p53; D006019:Glycolysis; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010427:Pentose Phosphate Pathway; D015398:Signal Transduction
D005227:Fatty Acids; D000581:Amidohydrolases; C020654:glutamin-(asparagin-)ase