Synthesis and property of chitosan graft copolymer by RAFT polymerization with tosylic acid-chitosan complex.
pH- and thermo-sensitive (1→4)-2-amino-2-deoxy-β-d-glucan (i.e. chitosan) graft copolymer was prepared by reversible addition fragmentation chain transfer polymerizations of N-isopropylacrylamide with 4-methylbenzenesulfonic acid (i.e. tosylic acid)-chitosan complex. The polymerization was controlled well, and the amino group of chitosan could be deprotected easily and mildly with 15% Tris solution. The model aldehyde vanillin was conjugated with amino group of chitosan-g-PNIPAM via Schiff base bond (Loading efficiency, LE=77.6 mg/g), and the drug release could be controlled with temperature and pH. This property may promote the chitosan graft copolymer to be used in the field of "smart" drug delivery.
School of Radiation Medicine and Protection, Medical College and Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou 215123, PR China. jj19860206july@163.com
Jing
J
Jiang
Xiaodi
X
Pan
Jinxin
J
Cao
Jianlin
J
Jiang
Daoben
D
Hua
Xiulin
X
Zhu
D001547:Benzaldehydes / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
C573194:4-methylbenzenesulfonic acid; D001547:Benzaldehydes; D001557:Benzenesulfonates; D011108:Polymers; D012545:Schiff Bases; D014867:Water; D048271:Chitosan; C100058:vanillin