Fixin' to divide.
In this issue of Molecular Cell, Yata et al. (2012) show that the mitotic kinase and cell-cycle regulator Plk1 can directly stimulate the DNA repair process, providing a potential mechanism of crosstalk between DNA repair and cell-cycle signaling.
David H. Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Duaa H
DH
Mohammad
Michael B
MB
Yaffe
D047390:Casein Kinase II / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051135:Rad51 Recombinase / Q000378:metabolism*; D059767:Recombinational DNA Repair; D000097869:Polo-Like Kinase 1
D047390:Casein Kinase II; D018797:Cell Cycle Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051135:Rad51 Recombinase; D000097869:Polo-Like Kinase 1; C495153:RAD51 protein, human