Synthesis of β-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.
We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one β-cyclodextrin (β-CD) containing block by a "click" reaction between azido-substituted β-CD and propargyl flanking copolymer. (1)H NMR study suggested a highly efficient conjugation of β-CD units by this approach. The obtained copolymer was used as a host macromolecule to construct assemblies in the presence of hydrophobic guests. For assemblies containing a hydrophobic polymer, their size can be simply adjusted by simply changing the content of hydrophobic component. By serving as a guest molecule, hydrophobic drugs can also be loaded accompanying the formation of nanoparticles, and the drug payload is releasable. Therefore, the copolymer synthesized herein can be employed as a carrier for drug delivery.
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Jianxiang
J
Zhang
Kristin
K
Ellsworth
Peter X
PX
Ma
D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D001386:Azides; D011108:Polymers; D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols; C031215:betadex