Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice.
The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. The group treated with BC703 at doses of 1, 5, and 10 mg/kg produced significant hepatoprotective effects against TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation in dose-dependent manners. Histopathological studies further substantiated the protective effect of BC703. These results show the hepatoprotective activity of aqueous extract from Platycodon grandiflorum on thioacetamide-induced fulminant hepatic failure.
Jong-Hwan
JH
Lim
Tae-Won
TW
Kim
Sang-Jin
SJ
Park
In-Bae
IB
Song
Myoung-Seok
MS
Kim
Hyo-Jung
HJ
Kwon
Eun-Sang
ES
Cho
Hwa-Young
HY
Son
Sang-Wook
SW
Lee
Joo-Won
JW
Suh
Jong-Woo
JW
Kim
Hyo-In
HI
Yun