Systemic inflammatory response after single-incision laparoscopic surgery versus standard laparoscopic approach.
OBJECTIVE
The extent of surgical trauma is reflected by systemic inflammatory response (SIR). The aim of this study was to assess SIR after single-incision laparoscopic surgery (SILS) versus the standard laparoscopic approach.


METHODS
Twenty pigs were assigned into 4 groups: SILS (group SILS), laparoscopy using 4 trocars (group LAPSC), pneumoperitoneum (group PNE), or a sham-operation (group Sham) group. Blood samples were taken at 0, 1, 3, 6, 24, and 48 hours and 1 week postoperation to measure tumor necrosis factor-α, interleukin (IL)-6, IL-18, and C-reactive protein serum levels.


RESULTS
No significant changes were noted among groups for each time point studied regarding tumor necrosis factor-α, IL-6, and IL-18. C-reactive protein levels were significantly lower (P<0.05) in group PNE compared with the other groups at 24 hours, 48 hours, and 1 week.


CONCLUSIONS
There is no difference in SIR after SILS versus the standard laparoscopic approach.
Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece. pipsil@med.duth.gr
Petros
P
Ypsilantis
Vasilios
V
Didilis
Christina
C
Tsigalou
Michael
M
Pitiakoudis
Anastasios
A
Karakatsanis
Apostolos
A
Margioulas
Constantinos
C
Simopoulos
D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D020382:Interleukin-18 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D011897:Random Allocation; D034421:Sus scrofa; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D020382:Interleukin-18; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein