[Diagnostic and therapeutic analyses for peritoneal malignant mesothelioma: a report of 26 women].
OBJECTIVE
To investigate the etiology, clinicopathologic features and prognosis of peritoneal malignant mesothelioma (PMM).


METHODS
The diagnostic and therapeutic data for PMM from March 2000 to December 2010 were retrospectively analyzed for 26 women. They had an age range of 41 - 78 years old. Among them, 21 patients (81%) had a history of exposure to asbestos. Their major symptoms were abdominal distension, abdominal pain, ascites and abdominopelvic mass. Some had cachexia. Intestinal obstruction occurred in all cases during a late stage.


RESULTS
Among them, the tumor marker of CA125 increased markedly in serum and ascitic samples. The positive rate of ascitic cytology was 31%. Type B ultrasound and CT (computed tomography) examinations showed ascites, peritoneal thickening and abdominopelvic mass and pie-shaped omentum. Their general pathological classifications were as follows: diffuse type (n = 23), localized type (n = 3), epithelial (n = 14), sarcoma (n = 3) and mixed type (n = 9). Cytoreductive surgery was performed in 16 cases. Ten patients underwent only laparoscopy while 23 patients received chemotherapy. The comparison of life span was not statistically significant between cytoreductive surgery and laparoscopy (P > 0.05); the difference of life span between ≤ 6 courses of chemotherapy and < 6 courses was not statistically significant (P > 0.05).


CONCLUSIONS
The history of exposure to asbestos is a risk factor for PMM. PMM with no specific clinical features should be combined with laboratory and imaging studies to make a timely clinical diagnosis. Final diagnosis should be based upon histopathological and immunohistochemical examinations. Surgery and chemotherapy do not prolong the life span of patients. And the patients have a very poor prognosis.
Department of Obstetrics & Gynecology, Yuyao People's Hospital, Yuyao 315400, China. Email: yyphshj@163.com.
Hua-Jiang
HJ
Shao
Jian-Ting
JT
Ma
Xiu-Er
XE
Yang
Li-Ping
LP
Xu
Chun-Lin
CL
Yang
D018394:CA-125 Antigen; D005260:Female; D006801:Humans; D008654:Mesothelioma; D009852:Omentum; D010534:Peritoneal Neoplasms; D010537:Peritoneum
D018394:CA-125 Antigen