Clinical significance of serum biomarkers in pediatric solid mediastinal and abdominal tumors.
Childhood cancer is the leading cause of death by disease among U.S. children between infancy and age 15. Despite successes in treating solid tumors such as Wilms tumor, disappointments in the outcomes of high-risk solid tumors like neuroblastoma have precipitated efforts towards the early and accurate detection of these malignancies. This review summarizes available solid tumor serum biomarkers with a special focus on mediastinal and abdominal cancers in children.
Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS332, Room D3040G, Memphis, TN 38105, USA.
John A
JA
Sandoval
City of Hope Cancer Center, Duarte, CA 91010, USA.
Linda H
LH
Malkas
City of Hope Cancer Center, Duarte, CA 91010, USA.
Robert J
RJ
Hickey
D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D002395:Catecholamines / Q000097:blood; D002648:Child; D004798:Enzymes / Q000097:blood; D006801:Humans; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000097:blood; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D036361:Peptide Hormones / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002395:Catecholamines; D004798:Enzymes; D008562:Membrane Glycoproteins; D036361:Peptide Hormones; D000509:alpha-Fetoproteins