Increased cardiac troponin T levels are related to inflammatory markers and various indices of renal function in chronic renal disease patients.
OBJECTIVE
Cardiovascular disease begins early in the course of chronic kidney disease (CKD), and the glomerular filtration rate (GFR) is an independent risk factor for it. There is little information on cardiac troponin concentrations in patients with CKD who have not commenced dialysis. Factors associated with this deleterious process are not completely understood, and we aimed to determine associated laboratory abnormalities of increased cardiac troponin T (cTnT) in patients with CKD.


METHODS
In this study, 104 patients (65 males and 39 females with mean age of 65 ± 15 years) were recruited. A detailed clinical history was recorded and routine biochemical variables and cTnT levels were measured. GFR was estimated (44.62 ± 14.38 mL/min/1.73 m(2)) using the modification of diet in renal disease study formula.


RESULTS
cTnT is correlated with blood urea (r = 0.262, p < 0.05), uric acid (r = 0.399, p < 0.001), blood phosphorus (r = 0.550, p < 0.001), triglyceride (r = 0.329, p = 0.011), C-reactive protein (CRP; r = 0.768, p < 0.001), renal resistive index (RRI; r = 0.412, p = 0.017), and GFR (r = -0.755, p = 0.011). On stepwise multiple regression analysis, increased CRP (≥12 mg/L), uric acid (≥5 mg/L), and RRI (≥0.70) were independent variables for increased cTnT status (r(2) = 0.053, p < 0.05).


CONCLUSIONS
Increased cTnT not only shows ongoing inflammation but also is a sensitive marker of functioning renal mass. It is strongly correlated with factors influencing the decline in renal function; thus, it can be used as a renal risk parameter.
Department of Nephrology, Baskent University, Ankara, Turkey.
Siren
S
Sezer
Sebnem
S
Karakan
Nurhan
N
Ozdemir
D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood* / Q000150:complications; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors; D020107:Troponin T / Q000097:blood*; D014421:Turkey / Q000453:epidemiology
D015415:Biomarkers; D020107:Troponin T