Imaging tumor sensitivity to a bioreductive prodrug: two for the price of one!
Hypoxia is an important characteristic of many solid tumors and has a major negative effect on treatment response. A way to combat this effect is with drugs called "bioreductive prodrugs" or "hypoxic cytotoxins," which are metabolized under hypoxia to toxic species. However, the patients with hypoxic tumors need to be identified.
Department of Radiation Oncology, Stanford University, Stanford, CA, USA. mbrown@stanford.edu
J Martin
JM
Brown
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D017341:Etanidazole / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000032:analysis*; D005466:Fluorocarbons
D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D017341:Etanidazole; D006845:Hydrocarbons, Fluorinated; C472752:CETN2 protein, human; C096011:2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; D005466:Fluorocarbons