Curative resection of combined neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
Neuroendocrine carcinoma of the gallbladder has very rarely been reported as it accounts for only 0.5% of all neuroendocrine tumors. It has a very aggressive biological behavior. These tumors are usually diagnosed at an advanced stage and surgical management is therefore not an option. We performed a hepatopancreaticoduodenectomy along with adjuvant chemotherapy in a 48-year-old patient with a neuroendocrine carcinoma of the gallbladder. The patient has been followed up at the outpatient clinic for 18 months without there having been any recurrence. Patients with a locally invasive neuroendocrine carcinoma in the gallbladder may benefit from aggressive surgical treatment followed by adjuvant chemotherapy. The primary management in high-grade metastatic tumors is, however, mainly medical.
Department of Surgery, School of Medicine, Pusan National University, Busan, Korea.
Dong Il
DI
Kim
Hyung Il
HI
Seo
Jee Yeon
JY
Lee
Hyun Sung
HS
Kim
Koon Taek
KT
Han
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D064847:Multimodal Imaging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed