Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands.
In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gazi, Ankara, Turkey.
Azime Berna
AB
Ozçelik
Semra
S
Utku
Fatma
F
Gümüş
Ayten Çelebi
AÇ
Keskin
Leyla
L
Açık
Sükran
S
Yılmaz
Adeviye
A
Ozgüngör
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D015245:Deoxyribonuclease BamHI / Q000037:antagonists & inhibitors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D010957:Plasmids; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D008024:Ligands; D009944:Organoplatinum Compounds; D004247:DNA; C031000:benzimidazole; D015245:Deoxyribonuclease BamHI