Automatic detection and analysis of the EEG sharp wave-slow wave patterns evoked by fluorinated inhalation anesthetics.
OBJECTIVE
The aim of this study was to develop a method for the automatic detection of sharp wave-slow wave (SWSW) patterns evoked in EEG by volatile anesthetics and to identify the patterns' characteristics.


METHODS
The proposed method consisted in the k-NN classification with a reference set obtained using expert knowledge, the morphology of the EEG patterns and the condition for their synchronization. The decision rules were constructed and evaluated using 24h EEG records in ten patients.


RESULTS
The sensitivity, specificity and selectivity of the method were 0.88 ± 0.10, 0.81 ± 0.13 and 0.42 ± 0.16, respectively. SWSW patterns' recruitment was strictly dependent on anesthetic concentration. SWSW patterns evoked by different types of anesthetics expressed different characteristics.


CONCLUSIONS
Synchronization criterion and adequately selected morphological features of "slow wave" were sufficient to achieve the high sensitivity and specificity of the method.


CONCLUSIONS
The monitoring of SWSW patterns is important in view of possible side effects of volatile anesthetics. The analysis of SWSW patterns' recruitment and morphology could be helpful in the diagnosis of the anesthesia effects on the CNS.
Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 Str., 02-109 Warszawa, Poland. eolejarczyk@ibib.waw.pl
Elzbieta
E
Olejarczyk
Adam
A
Jozwik
Wojciech
W
Zmyslowski
Aleksander
A
Sobieszek
Radoslaw
R
Marciniak
Tomasz
T
Byrczek
Przemyslaw
P
Jalowiecki
Tiaza
T
Bem
D000368:Aged; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee; D001921:Brain / Q000187:drug effects*; D058256:Brain Waves / Q000187:drug effects*; D000077335:Desflurane; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008738:Methyl Ethers / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D000077149:Sevoflurane; D012815:Signal Processing, Computer-Assisted
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane