The role of glutamate in diabetic and in chemotherapy induced peripheral neuropathies and its regulation by glutamate carboxypeptidase II.
Glutamate has been implicated in the pathogenesis of several diseases on the central nervous system, but recent studies have also suggested that it can be involved also in the onset and course of peripheral neuropathies. Given the increasing evidence of this possibility, several attempts have been performed in order to modulate its activity. Among them, glutamate carboxypeptidase II (GCP II) inhibition demonstrated promising results in different models of peripheral nerve damage, including diabetic and toxic neuropathies.
Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy. valentina.carozzi1@unimib.it
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D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D064420:Drug-Related Side Effects and Adverse Reactions; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D043425:Glutamate Carboxypeptidase II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D017933:Peripheral Nervous System / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D018698:Glutamic Acid; D043425:Glutamate Carboxypeptidase II