Groucho: a corepressor with instructive roles in development.
Drosophila Groucho (Gro) is the founding member of a family of metazoan corepressors. Gro mediates repression through interactions with a myriad of DNA-binding repressor proteins to direct the silencing of genes involved in many developmental processes, including neurogenesis and patterning of the main body axis, as well as receptor tyrosine kinase/Ras/MAPK, Notch, Wingless (Wg)/Wnt, and Decapentaplegic (Dpp) signaling. Gro mediates repression by multiple molecular mechanisms, depending on the regulatory context. Because Gro is a broadly expressed nuclear factor, whereas its repressor partners display restricted temporal and spatial distribution, it was presumed that this corepressor played permissive rather than instructive roles in development. However, a wide range of studies demonstrates that this is not the case. Gro can sense and integrate many cellular inputs to modulate the expression of variety of genes, making it a versatile corepressor with crucial instructive roles in development and signaling.
Department of Chemistry & Biochemistry and Molecular Biology Institute, University of California, Los Angeles, California, USA.
Wiam
W
Turki-Judeh
Albert J
AJ
Courey
D000818:Animals; D019521:Body Patterning; D002467:Cell Nucleus / Q000378:metabolism; D056970:Co-Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D015398:Signal Transduction
D056970:Co-Repressor Proteins