Hyuganatsu orange (Citrus tamurana Hort. Ex Tanaka) contains a water soluble substance that suppresses bone loss in ovariectomized rats.
We investigated whether Hyuganatsu orange (Citrus tamurana Hort. ex Tanaka) contains water and acetic-acid soluble substances that increase bone mineral density (BMD) in ovariectomized rats. In in vivo study, femoral BMD can significantly increased. In in vitro study, tartrate-resistant acid phosphatase (TRAP) positive cells significantly decreased. We speculate that Hyuganatsu orange contains biologically active substances other than hesperidin that increase BMD.
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. myama@fc.miyazaki-u.ac.jp
Masatoshi
M
Yamaguchi
Hiroshi
H
Sameshima
Tsuyomu
T
Ikenoue
Makoto
M
Tsuboi
Muneaki
M
Hidaka
Kazuhiko
K
Arimori
D019342:Acetic Acid; D000135:Acid Phosphatase; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D032084:Citrus sinensis / Q000737:chemistry*; D005260:Female; D005269:Femur; D007527:Isoenzymes; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012995:Solubility; D000071681:Tartrate-Resistant Acid Phosphatase; D014867:Water
D007527:Isoenzymes; D010936:Plant Extracts; D014867:Water; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D019342:Acetic Acid