An unusual cutaneous tumor: African histoplasmosis following mudbaths: case report and review.
African histoplasmosis, caused by Histoplasma capsulatum var. duboisii, is endemic in Africa. The disease usually involves the skin, subcutaneous tissue, and bones. A case of African histoplasmosis presenting as a cutaneous tumor and non-healing wound in a 66-year-old immunocompetent male residing in Africa, the first ever reported following mudbaths and acupuncture, is hereby reported. Diagnosis was confirmed by means of polymerase chain reaction performed on tissue material. The patient was started on long-term itraconazole therapy and he responded well. African histoplasmosis should be included in the differential diagnosis of non-healing wounds or tumor-like lesions, especially in the context of mudbaths in an endemic area.
4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece. tsiodras@med.uoa.gr
Sotirios
S
Tsiodras
Miranda
M
Drogari-Apiranthitou
Konstantinos
K
Pilichos
Konstantinos
K
Leventakos
Theodoros
T
Kelesidis
Maria Jose
MJ
Buitrago
Georgios
G
Petrikkos
Ioannis
I
Panayiotides
D000349:Africa / Q000453:epidemiology; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D006660:Histoplasmosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D009094:Mud Therapy; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole