Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice.
Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Myeloid differentiation factor 88 (MyD88) is an adaptor protein for TLR4. Previously, we found MyD88-deficient mice fed a high-fat diet (HFD) exhibited a severe diabetic phenotype. Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of diabetes. In the present study, we found SCD1 was dramatically increased in HFD-fed MyD88-deficient mice liver. This finding showed the novel linkage between MyD88 and SCD1 in the development of diabetes mellitus.
Department of Pharmacotherapy, Hiroshima University, Hiroshima, Japan. b060720@hiroshima-u.ac.jp
Shota
S
Yokoyama
Toru
T
Hosoi
Koichiro
K
Ozawa
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000378:metabolism*; D059305:Diet, High-Fat / Q000379:methods; D051273:Glucose Transporter Type 2 / Q000235:genetics / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D053594:Myeloid Differentiation Factor 88 / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D013230:Stearoyl-CoA Desaturase / Q000235:genetics* / Q000378:metabolism*
D051273:Glucose Transporter Type 2; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; C495682:Slc2a2 protein, mouse; C490333:Scd1 protein, mouse; D013230:Stearoyl-CoA Desaturase; D005952:Glucose-6-Phosphatase