Mucocutaneous candidiasis in a mandrill (Mandrillus sphinx).
An adult male mandrill (Mandrillus sphinx) suffered from chronic ulceration of the facial and gluteal skin and the oral and nasal mucosa. The ulcers were resistant to therapy and led to deterioration in the general condition of the animal. Microscopical examination revealed a severe, chronic, multifocal, granulomatous and eosinophilic dermatitis and panniculitis. There was also stomatitis and rhinitis with numerous intralesional fungal elements. These organisms were identified by immunohistochemistry, transmission electron microscopy, polymerase chain reaction and fungal culture as Candida albicans. Species identification was confirmed by MALDI-TOF mass spectrometry. A specific predisposing immunosuppressive factor for the deep chronic mucocutaneous candidiasis was not identified; however, social stress and/or a primary defect in cell-mediated immunity could not be excluded as possible causes for a predisposing immunodeficiency in the animal.
German Primate Centre, Pathology Unit, Kellnerweg 4, 37077 Göttingen, Germany. mzoeller@dpz.eu
M
M
Zöller
S
S
Silinski
C
C
Ludwig
M
M
Weig
K
K
Mätz-Rensing
F-J
FJ
Kaup
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000302:isolation & purification* / Q000502:physiology; D002178:Candidiasis, Chronic Mucocutaneous / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004359:Drug Therapy, Combination / Q000662:veterinary; D054884:Host-Pathogen Interactions; D016867:Immunocompromised Host; D008297:Male; D048528:Mandrillus; D008992:Monkey Diseases / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D019226:Oral Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods / Q000662:veterinary; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents