Velocity-jump models with crowding effects.
Velocity-jump processes are discrete random-walk models that have many applications including the study of biological and ecological collective motion. In particular, velocity-jump models are often used to represent a type of persistent motion, known as a run and tumble, that is exhibited by some isolated bacteria cells. All previous velocity-jump processes are noninteracting, which means that crowding effects and agent-to-agent interactions are neglected. By neglecting these agent-to-agent interactions, traditional velocity-jump models are only applicable to very dilute systems. Our work is motivated by the fact that many applications in cell biology, such as wound healing, cancer invasion, and development, often involve tissues that are densely packed with cells where cell-to-cell contact and crowding effects can be important. To describe these kinds of high-cell-density problems using a velocity-jump process we introduce three different classes of crowding interactions into a one-dimensional model. Simulation data and averaging arguments lead to a suite of continuum descriptions of the interacting velocity-jump processes. We show that the resulting systems of hyperbolic partial differential equations predict the mean behavior of the stochastic simulations very well.
School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Katrina K
KK
Treloar
Matthew J
MJ
Simpson
Scott W
SW
McCue
D001419:Bacteria / Q000166:cytology; D002452:Cell Count; D008954:Models, Biological; D009068:Movement; D013269:Stochastic Processes