[The influence of the androgens on the process of the experimental diabetes and the activity of the synthesis of the nucleic acids in the male rats liver].
The aim of this research is to study the dependence the gravity of diabetes course and the activity of the biosynthetical processes in the liver from the level of the sexual steroides in the male-rats blood on the model of the alloxan diabetes. The experiments were carried out on 80 male rats (weight 180-200g). The diabetes has been reproduced by the single injection of alloxan per 200mg/kg. The content of glucose, testosterone, estradiole and corticosterone have been determined in the blood of the animals. Activity of the syntheses of the nucleic acids in the liver has been researched by the radiometrical method on 14, 30, 45 and 90 days of the experiment. On all stages of the observation has been revealed the inverse relation between the concentration of the testosterone in the blood and the gravity of the experimental diabetes which was determined by the degree of hyperglycemya and the changes of the coefficient of sexual hormones ratio, the content of estradiol, corticosterone and activity of the syntheses of the nucleic acids in the tissue of the liver. The injection of the androgen during two week caused jump increasing the testosterone concentration, approaching the sexual steroids ratio to the norm, decreasing the glucose, estradiole, corticosterone content and also the reduction the nucleic acids syntheses activity in the liver. It was shown the positive influence of the androgens on development of the compensatory processes in the male rats, which course the decrease the experimental diabetes gravity.
N A
NA
Didebuladze
Ts M
TsM
Sumbadze
S A
SA
Gvidiani
I I
II
Korkiia
D000728:Androgens / Q000008:administration & dosage*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009696:Nucleic Acids / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D013739:Testosterone / Q000097:blood
D000728:Androgens; D001786:Blood Glucose; D009696:Nucleic Acids; D013739:Testosterone; D004958:Estradiol; D003345:Corticosterone