Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions.
Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.
Rajesh G
RG
Gonnade
Sekai
S
Iwama
Ryusuke
R
Sugiwake
Kochunnoonny
K
Manoj
Hiroki
H
Takahashi
Hirohito
H
Tsue
Rui
R
Tamura
D018360:Crystallography, X-Ray; D007660:Ketoprofen / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D007660:Ketoprofen