Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats.
Astaxanthin at 0.01 or 0.05% of the diet was supplied to diabetic rats for 12 wk. Astaxanthin intake significantly increased its deposit in plasma, and retained glutathione content, reduced the production of reactive oxygen species, interleukin-6, tumor necrosis factor-α, and monocyte chemoattractant protein-1 in blood and kidney of diabetic rats (P < 0.05). Astaxanthin treatments also significantly decreased plasma levels of C-reactive protein and von Willebrand factor in diabetic rats (P < 0.05). Astaxanthin intake at 0.05% significantly diminished plasminogen activator inhibitor-1 and factor VII activities, enhanced antithrombin-III and protein C activities in circulation (P < 0.05). These results support that astaxanthin could attenuate diabetes associated coagulatory, oxidative, and inflammatory stress.
Dept of Food and Nutrition, Providence Univ, Taichung City, Taiwan.
Kung-Chi
KC
Chan
Pei-Jain
PJ
Pen
Mei-Chin
MC
Yin
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism; D018932:Chemokine CCL2 / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005978:Glutathione / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000187:drug effects; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D024341:Xanthophylls / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000975:Antioxidants; D001786:Blood Glucose; C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D024341:Xanthophylls; C005948:astaxanthine; D002097:C-Reactive Protein; D005978:Glutathione