The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT.
Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission. Biofilm development is positively regulated by hmsT, encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of hmsT.
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. sunyc@ipbcams.ac.cn
Yi-Cheng
YC
Sun
Xiao-Peng
XP
Guo
B Joseph
BJ
Hinnebusch
Creg
C
Darby
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D017173:Caenorhabditis elegans / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D015398:Signal Transduction; D014158:Transcription, Genetic; D015010:Yersinia pestis / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; C122178:HMST protein, Yersinia pestis; C074889:RcsB protein, Bacteria