The long and short of microRNAs in the kidney.
MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.
Rangos Research Center, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA. jacqueline.ho2@chp.edu
Jacqueline
J
Ho
Jordan A
JA
Kreidberg
D000818:Animals; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000196:embryology / Q000502:physiology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology; D035683:MicroRNAs / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D035683:MicroRNAs