Pallambins A and B, unprecedented hexacyclic 19-nor-secolabdane diterpenoids from the Chinese liverwort Pallavicinia ambigua.
Pallambins A (1) and B (2), two novel 19-nor-7,8-secolabdane diterpenoids with unprecedented tetracyclo[4.4.0(3,5).0(2,8)]decane skeletons, along with a pair of structurally related isomers, pallambins C (3) and D (4), were isolated from the Chinese liverwort Pallavicinia ambigua. Their structures with absolute configurations were determined by means of NMR, X-ray diffraction, and CD analyses. Their preliminary cytotoxicity to human cancer cells was also tested.
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. China.
Li-Ning
LN
Wang
Jiao-Zhen
JZ
Zhang
Xia
X
Li
Xiao-Ning
XN
Wang
Chun-Feng
CF
Xie
Jin-Chuan
JC
Zhou
Hong-Xiang
HX
Lou
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D035926:Hepatophyta / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation
D004224:Diterpenes; C572042:pallambin A; C572043:pallambin B