Neuron transplantation partially reverses an obesity disorder in mice.
Mice lacking leptin receptors are grossly obese and diabetic, in part due to dysfunction in brain circuits important for energy homeostasis. Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels.
Janelia Farm Research Campus, HHMI, Ashburn, VA 20147, USA. sternsons@janelia.hhmi.org
Scott M
SM
Sternson