Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers.
Well-defined graft copolymers were obtained using a copper-catalysed azide-alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(ε-caprolactone) and poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic copolymers proved to form micelles that could be used as potential drug carriers.
Institut Charles Gerhardt Montpellier UMR5253 CNRS-UM2-ENSCM-UM1-Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier II cc1702, Place Eugène Bataillon, 34095 Montpellier, France.
Brieuc
B
Guillerm
Vincent
V
Darcos
Vincent
V
Lapinte
Sophie
S
Monge
Jean
J
Coudane
Jean-Jacques
JJ
Robin
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008823:Micelles; D011073:Polyamines / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D004337:Drug Carriers; D008823:Micelles; D011073:Polyamines; D011091:Polyesters; D011108:Polymers; D014230:Triazoles; C117403:poly(2-methyl-2-oxazoline); C016240:polycaprolactone; D003300:Copper