Antibody to P. falciparum in pregnancy varies with intermittent preventive treatment regime and bed net use.
BACKGROUND
Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development.


RESULTS
Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae.


CONCLUSIONS
Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity.
Department of Medicine, RMH/WH, University of Melbourne, Parkville, Victoria, Australia.
Elizabeth H
EH
Aitken
Bernard
B
Mbewe
Mari
M
Luntamo
Teija
T
Kulmala
James G
JG
Beeson
Per
P
Ashorn
Stephen J
SJ
Rogerson
D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood; D002460:Cell Line; D018890:Chemoprevention / Q000379:methods; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy*; D057147:Mosquito Nets / Q000706:statistics & numerical data; D018512:Parasitemia / Q000453:epidemiology; D010507:Periodicity; D010963:Plasmodium falciparum / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy*; D016036:Seroepidemiologic Studies; D055815:Young Adult
D000913:Antibodies, Protozoan