A MRI-compatible system for whisker stimulation.
We describe here a system for whisker stimulation designed for functional studies in high-field magnetic resonance imaging (MRI) environments. This system, which incorporates real-time optical monitoring of the vibration stimulus, can generate well-controlled and reproducible whisker deflections with amplitudes up to 2mm and frequencies up to 75 Hz, suitable for functional magnetic resonance imaging (fMRI) studies of animals. Whiskers on either or both sides of the head can be stimulated selectively during fMRI experiments without removing the subject from the magnet. With a user-friendly graphical interface of a computer, a user can conveniently control both the whisker vibration and gating of the MR imager, and synchronize the stimulation with the fMRI acquisition to ensure precise timing of the stimulus presentation. This whisker stimulation system should facilitate a wide variety of fMRI investigations of the neural systems mediating sensory information from the whiskers.
Center for Basic MR Research, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA. LLi@northshore.org
Limin
L
Li
Craig
C
Weiss
Andrew C
AC
Talk
John F
JF
Disterhoft
Alice M
AM
Wyrwicz
D000818:Animals; D005260:Female; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D010812:Physical Stimulation / Q000379:methods; D011817:Rabbits; D013003:Somatosensory Cortex / Q000502:physiology; D014584:User-Computer Interface; D014732:Vibration; D014738:Vibrissae / Q000294:innervation*