[Biological study in schizophrenia].
Schizophrenia is associated with enormous morbidity, mortality, personal disability, and social cost. Although considerable research on schizophrenia has been performed, the etiology of this disease has not been fully elucidated. In recent years, imaging and genetic technologies have been developed dramatically. Disturbances in glutamate and GABAergic neurotransmission may underlie the pathophysiology of schizophrenia. We attempted an integrative review, of studies pertaining to recent advances of schizophrenia research with a focus on neuroimaging and genetic studies. Additionally, we present the preliminary findings of the clinical research in our outpatient unit, specialized for early intervention, at the University of Tokyo Hospital.
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Kiyoto
K
Kasai
Akane
A
Yoshikawa
Takanobu
T
Natsubori
Shinsuke
S
Koike
Tatsuya
T
Nagai
Tsuyoshi
T
Araki
Yukika
Y
Nishimura
Kazuya
K
Iwamoto
D000818:Animals; D006801:Humans; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*; D057170:Translational Research, Biomedical