Epiphany root canal sealer prepared with resinous solvent is  irritating to rat subcutaneous tissues.
OBJECTIVE
This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues.


METHODS
Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solvent (RS); GII, Epiphany prepared with 1 drop of RS and photoactivated; GIII, Epiphany associated with self-etch primer and prepared with 1 drop of RS; GIV, Epiphany associated with self-etch primer, prepared with 1 drop of RS and photoactivated. The filled tubes were implanted into 4 different regions of the dorsum of 20 adult male rats.


RESULTS
After 7, 14 and 21 days, all groups presented a moderate to severe chronic inflammation, necrosis and foreign-body giant cells. At 42 days, although the intensity of chronic inflammatory reaction decreased, the other features still were observed.


CONCLUSIONS
The Epiphany sealer prepared with the RS was irritating to rat subcutaneous tissues.
School of Dentistry, University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo, Brazil.
Élcio
É
Daleffe
José-Estevam
JE
Vieira-Ozório
José-Estevam
JE
Sousa-Neto
Danyel-Elias
DE
da-Cruz-Perez
D000818:Animals; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D008422:Materials Testing; D051381:Rats; D017208:Rats, Wistar; D012117:Resins, Synthetic; D012387:Root Canal Filling Materials / Q000009:adverse effects*; D012997:Solvents; D040521:Subcutaneous Tissue / Q000187:drug effects*
D012117:Resins, Synthetic; D012387:Root Canal Filling Materials; D012997:Solvents; C486893:epiphany sealer