A critical appraisal of the hemodynamic signal driving liver regeneration.
BACKGROUND
Many aspects of the signaling mechanisms involved in the initiation of hepatic regeneration are under current investigation. Nevertheless, the actual mechanisms switching liver regeneration on and off are still unknown. Hemodynamic changes in the liver following partial hepatectomy have been suggested to be a primary stimulus in triggering liver regeneration. Most of the new knowledge about the impact of hemodynamic changes on liver regeneration is both conceptually important and directly relevant to clinical problems.


OBJECTIVE
The purpose of this review is therefore to exclusively address the hemodynamic signal driving the liver regeneration process.
Institute for Experimental Surgery, University of Rostock, 18055 Rostock, Germany. kerstin.abshagen@uni-rostock.de
Kerstin
K
Abshagen
Christian
C
Eipel
Brigitte
B
Vollmar
D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006498:Hepatectomy; D006499:Hepatic Artery / Q000503:physiopathology; D022781:Hepatocytes / Q000502:physiology; D006801:Humans; D007728:Kupffer Cells / Q000502:physiology; D008099:Liver / Q000098:blood supply*; D008115:Liver Regeneration / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology; D011169:Portal Vein / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology