Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV.
We describe here the synthesis and characterization of new sulfonated and carboxylated-containing N-donor ligands [Na(4)(edts)]·4H(2)O (2), [Na(2)(dmeddp)]·2H(2)O (3) and [Na(4)(edtp)]·H(2)O (4) (edts = ethylene-diamine- N,N,N',N'-tetraethylenesulfonate ion; dmeddp = dimethyl-ethylene-diamine-N,N,N',N'-tetra-3-propionate ion; edtp = ethylene-diamine-N,N,N',N'-tetra-3-propionate ion) and their corresponding metal (Ni, Co, Cu and Zn) complexes. Mainly, UV-Vis and a computer aided analysis of the EPR spectra provided information on the geometry and structure of the complexes in solution. Some of the metal complexes inhibit HIV replication when treating both pre- and post-infected PBMC cells, and hustle the inhibitory effect compared to the metal salts alone.
Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain.
Sandra
S
García-Gallego
Javier Sánchez
JS
Rodríguez
José Luis
JL
Jiménez
Michela
M
Cangiotti
Maria Francesca
MF
Ottaviani
M Ángeles
MÁ
Muñoz-Fernández
Rafael
R
Gómez
F Javier
FJ
de la Mata
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002614:Chelating Agents / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D006678:HIV / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008422:Materials Testing; D009584:Nitrogen / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D028561:Transition Elements / Q000737:chemistry*
D019380:Anti-HIV Agents; D002614:Chelating Agents; D008024:Ligands; D009942:Organometallic Compounds; D028561:Transition Elements; D009584:Nitrogen