[The expression and significance of IGF-1R in nasal polyp and its relationship with allergic rhinitis].
OBJECTIVE
To study the expression of insulin-like growth factor-1 receptor(IGF-1R) in nasal polyps and its relationship with allergic rhinitis.


METHODS
The mRNA and protein expression of IGF-1R in 40 cases (20 cases with allergic rhinitis and 20 cases without) nasal polyps tissue (the CRSWNP group) and 20 middle turbinate tissue samples (the control group) were examined by fluorescence quantitative polymerase chain reaction (FQ-PCR) and immunohistochemistry.


RESULTS
The positive staining rate of IGF-1R protein of nasal polyps tissue is 70.8% and that of control is 12.3%, the expression of IGF-1R mRNA of nasal polyp is 0.748 +/- 0.111,which is significant higher than that of the control group is 0.107 +/- 0.208 (P < 0.01). No significant difference of the expression of IGF-1R mRNA between with and without allergic rhinitis cases and between with and without endoscopy sinus surgery history cases in the CRSWNP group.


CONCLUSIONS
The overexpression of IGF-1R maybe play important roles in the formation of nasal polyp. Hypersensitivity reaction type I mediated by IgE has no contribution to the overexpression of the IGF-1R.
Department of Otolaryngology-Head and Neck Oncology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China. ninghe_gx@sina.com
Ning
N
He
Jianping
J
Liang
Jun
J
Chen
Xiangyang
X
Zhou
Haiming
H
Wei
Xiangzhen
X
Zhou
Tao
T
Wang
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D055815:Young Adult
D012333:RNA, Messenger; D017526:Receptor, IGF Type 1