Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells.
Myeloid derived suppressor cells play a critical role in T cell suppression in cancer. Here, we discuss the mechanisms of how MDSC suppress CD4(+) or CD8(+) T cells in an antigen dependent or non-dependent manner.
Department of Internal Medicine, University of South Florida, Tampa, FL 33612, United States. snagaraj@health.usf.edu
Srinivas
S
Nagaraj
Dmitry I
DI
Gabrilovich
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D019139:Tumor Escape
D000951:Antigens, Neoplasm