Mouse intravenous challenge models and applications.
Murine intravenous (IV) challenge models have been widely used in medical mycology to study fungal virulence, host responses, and antifungal efficacy. This chapter describes the well-characterised Candida albicans IV challenge model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. d.m.maccallum@abdn.ac.uk
Donna M
DM
MacCallum
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000276:immunology / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology*; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D054884:Host-Pathogen Interactions; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents