MMP9: a novel function in synaptic plasticity.
Matrix metalloproteinase-9 (MMP-9), an extracellularly acting, Zn(2+)-dependent endopeptidase is a subject to complex regulation at the level of transcription, mRNA dendritic translocation, and local translation as well as protein activation, as it is released extracellularly in a latent, pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity. In neurons, MMP-9 is present at the postsynaptic domains of excitatory synapses. Here, we review the role of MMP-9 in induction of structural dendritic spine modifications and in synaptic plasticity. In particular, we focus on local translation, activity-dependent secretion and activation of MMP-9 leading to its role in long term potentiation and regulation of remodeling of dendritic spines.
Nencki Institute, 02-093 Warsaw, Pasteura 3, Poland.
Magdalena
M
Dziembowska
Jakub
J
Wlodarczyk
D049229:Dendritic Spines / Q000502:physiology; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000235:genetics / Q000378:metabolism; D019706:Excitatory Postsynaptic Potentials; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D009473:Neuronal Plasticity / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D013569:Synapses / Q000502:physiology
D004792:Enzyme Precursors; D012333:RNA, Messenger; D020780:Matrix Metalloproteinase 9