Antiviral effect of maraviroc in semen: a case report.
We describe the antiviral effect of maraviroc in a patient who had been shedding high levels of HIV-1 in seminal fluid for three years despite an undetectable blood plasma viral load. Adding maraviroc to HAART stopped the seminal shedding. We discuss the mechanisms involved and the effect on sexual transmission.
Laboratory of Virology, INSERM U1043, IFB, CHU de Toulouse, Université Paul Sabatier - Toulouse 3, Toulouse, France. pasquier.c@chu-toulouse.fr
Christophe
C
Pasquier
Nathalie
N
Moinard
Karine
K
Sauné
Myriam
M
Daudin
Stéphanie
S
Trancart
Patrice
P
Massip
Jacques
J
Izopet
Louis
L
Bujan
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D003510:Cyclohexanes / Q000627:therapeutic use*; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D000077592:Maraviroc; D012661:Semen / Q000821:virology*; D013076:Sperm Count; D014230:Triazoles / Q000627:therapeutic use*; D019562:Viral Load
D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D014230:Triazoles; D000077592:Maraviroc