Innate immunity to TB: a druggable balancing act.
Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.
Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK. a.lalvani@imperial.ac.uk
Ajit
A
Lalvani
Marcel A
MA
Behr
Saranya
S
Sridhar