Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: a case report.
Simultaneous multiple malignancies of the larynx are rarely reported. In             this study, we describe a case with simultaneous laryngeal, moderately differentiated             squamous cell carcinoma (SCC) and primary malignant fibrous histiocytoma (MFH)             in a patient presenting with progressive hoarseness and without cervical lymphadenopathy.             The clinical presentation, intraoperative findings, radiographic images and pathology             slides are presented. The diagnosis was confirmed using H&E staining and immunohistochemical             testing. A partial laryngectomy with bilateral neck selective dissection was performed.             The patient survived for more than 46 months following surgery without recurrence             or metastasis. To our knowledge, this is the first report of a case with simultaneous             laryngeal SCC and primary MFH in the English literature. The results indicate             that the markers used to assess the prognosis of MFH may also be used to assess             simultaneous laryngeal SCC and primary MFH, and that laryngectomy to preserve             function may be performed in early-stage patients.
Department of Otorhinolaryngology - Head and Neck Surgery, Hangzhou First People's Hospital, Hangzhou, Zhejiang, PR China. xiaolinz@sohu.com
Xiaolin
X
Cao
Jun
J
Liu
Youyang
Y
Zheng
Qiaoyun
Q
Li
Yaoshu
Y
Teng
Yong
Y
Li
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome