Synthesis of methoxybenzoflavones and assignments of their NMR data.
A phytotoxic root exudate from Acroptilon repens was identified as 7,8-benzoflavone, an inhibitor of cytochrome P450 1A2 and activator of cytochrome P450 3A4. The synthetic 5,6-benzoflavone also is a potent phytotoxin. Six 7,8-benzoflavones and eight 5,6-benzoflavones were synthesized in this study. The NMR data for a few of these compounds have been previously reported; however, the NMR data for most of them have not been reported. For reference purposes, the complete NMR data for the 14 benzoflavones are described.
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul, 143-701, Korea.
Doseok
D
Hwang
Geunhyeong
G
Jo
Jiye
J
Hyun
Sung Dae
SD
Lee
Dongsoo
D
Koh
Yoongho
Y
Lim
D001571:Benzoflavones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards
D001571:Benzoflavones