Ciprofloxacin photosensitized oxidation of 2'-deoxyguanosine-5'-monophosphate in neutral aqueous solution.
Laser flash photolysis studies have been carried out to investigate the reactions of ciprofloxacin (CPX) with 2'-deoxyguanosine-5'-monophosphate (dGMP), N, N, N', N'-tetramethyl-p-phenylenediamine (TMPD) and ferulic acid (FCA) in neutral aqueous solutions, respectively. CPX triplet state ((3)CPX*) can be quenched by TMPD, FCA and dGMP, with rate constants of 1.8 × 10(9), 1.5 × 10(9) and 5.8 × 10(7) dm(3) mol(-1) s(-1), respectively. TMPD radical cation (TMPD(·+)) and FCA radical cation (FCA(·+)) were observed directly. The formation rate of CPX radical anion (CPX(·-)) was determined to be 1.5 × 10(9) dm(3) mol(-1) s(-1). Redox reaction of dGMP was investigated through competing reactions using TMPD and FCA as probe. The triplet energy of CPX was determined to be 262 kJ mol(-1). Electron transfer from TMPD, FCA and dGMP to (3)CPX* was proposed.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Yancheng
Y
Liu
Peng
P
Zhang
Haixia
H
Li
Wenfeng
W
Wang
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002412:Cations; D002939:Ciprofloxacin / Q000737:chemistry*; D003848:Deoxyguanine Nucleotides / Q000737:chemistry*; D004583:Electrons; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002412:Cations; D003848:Deoxyguanine Nucleotides; D017319:Photosensitizing Agents; D012996:Solutions; D014867:Water; D002939:Ciprofloxacin; C007257:2'-deoxyguanosine 5'-phosphate