Multiple myeloma presenting with hepatosplenomegaly.
Multiple myeloma, a clonal plasma cell disorder, commonly affects adults above 50 years age and accounts for about 10% of all hematological malignancies. Anemia, bone pains, renal failure are the most common symptoms at presentation. Though extra-medullary extra-osseous disease is well known in the course of the disease, initial presentation with extramedullary disease alone is rare. Such presentation may represent poor biology of the disease and/or advanced stage. Early diagnosis and treatment may improve outcomes. We herewith report the case of a 43 year old lady who presented with hepatosplenomegaly, without any classical manifestations of multiple myeloma and discuss the relevant literature.
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500082.
Krishna Mohan
KM
Mallavarapu
Senthil
S
Rajappa
Vijay Gandhi
VG
Linga
Sadashivudu
S
Gundeti
Raghunadharao
R
Digumarthi
Shantveer G
SG
Uppin
D000005:Abdomen / Q000000981:diagnostic imaging; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006529:Hepatomegaly / Q000209:etiology* / Q000628:therapy; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011719:Pyrazines / Q000627:therapeutic use; D013163:Splenomegaly / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone