Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology.
OBJECTIVE
In patients with ischaemic heart failure (HF), myocardial dysfunction often progresses. Elevated levels of soluble ST2 (sST2) are associated with a poor prognosis, but an association between sST2 and worsening heart failure per se has not been established. We assessed the association between sST2 and cause-specific outcome in 1449 patients enrolled in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA study).


RESULTS
Soluble ST2 was measured with a highly sensitive immunoassay in 1449 patients ≥60 years of age with left ventricular ejection fraction (LVEF) ≤40% due to ischaemic heart disease. By Cox regression analyses, we found sST2 to be associated with the primary endpoint, i.e. a composite of cadiovascular (CV) death, non-fatal myocardial infarction, or stroke, as well as all pre-defined secondary endpoints in the CORONA study, even after adjustment for baseline clinical variables. After adjustment for N-terminal pro brain natriuretic peptide and C-reactive protein, the association between sST2 and the primary endpoint was attenuated and no longer statistically significant. However, sST2 remained associated with death due to worsening HF, hospitalization due to worsening HF, and hospitalization due to any CV cause, even after full adjustment.


CONCLUSIONS
Soluble ST2 is associated with adverse outcomes in older patients with systolic, ischaemic HF. In particular, sST2 is independently associated with worsening HF.
Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway. kaspar.broch@rikshospitalet.no
Kaspar
K
Broch
Thor
T
Ueland
Ståle H
SH
Nymo
John
J
Kjekshus
Johannes
J
Hulthe
Pieter
P
Muntendam
John J
JJ
McMurray
John
J
Wikstrand
John G
JG
Cleland
Pål
P
Aukrust
Lars
L
Gullestad
D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000473:pathology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011956:Receptors, Cell Surface / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results; D018570:Risk Assessment; D013318:Stroke Volume; D017211:Treatment Failure; D016277:Ventricular Function, Left
D015415:Biomarkers; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain