Hfq regulates biofilm gut blockage that facilitates flea-borne transmission of Yersinia pestis.
The plague bacillus Yersinia pestis can achieve transmission by biofilm blockage of the foregut proventriculus of its flea vector. Hfq is revealed to be essential for biofilm blockage formation and acquisition and fitness of Y. pestis during flea gut infection, consistent with posttranscriptional regulatory mechanisms in plague transmission.
Paul G. Allen School for Global Animal Health and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Katherine A
KA
Rempe
Angela K
AK
Hinz
Viveka
V
Vadyvaloo
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D041981:Gastrointestinal Tract / Q000382:microbiology; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D054884:Host-Pathogen Interactions; D005423:Siphonaptera / Q000382:microbiology*; D014158:Transcription, Genetic; D015010:Yersinia pestis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D001426:Bacterial Proteins