Stage grouping in tumors of the ethmoid sinuses and the nasal cavity using the sixth edition of the UICC classification of malignant tumors.
BACKGROUND
The purpose of this study was to evaluate the prognostic impact of the sixth edition of the Union Internationale Contre le Cancer (UICC) classification and different TNM-based stage groupings for malignant tumors of the ethmoid sinuses and the nasal cavity.


METHODS
We conducted a retrospective analysis of 98 patients with malignant tumors of the ethmoid sinuses and the nasal cavity between 1967 and 2003. The UICC classification of the sixth edition and the T and N Integer Score (TANIS) and Hart were tested for their prognostic significance.


RESULTS
In univariate analysis, all stage groupings revealed discriminatory power for overall survival (OS; p < .05), however, in multivariate analysis only the UICC-stage grouping (p = .033) and the TANIS-8 scheme (p = .044) predicted OS. The TANIS did not have a better prognostic quality than the sixth edition of the UICC classification.


CONCLUSIONS
The UICC-stage grouping of the sixth edition is a good prognostic index for malignant tumors of the ethmoid sinuses and the nasal cavity.
Department of Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, 50931 Cologne, Germany. mattheskreppel@yahoo.de
Matthias
M
Kreppel
Martin
M
Scheer
Dirk
D
Beutner
Uta
U
Drebber
Robert
R
Semrau
Joachim E
JE
Zöller
Orlando
O
Guntinas-Lichius
D000368:Aged; D000704:Analysis of Variance; D059248:Chemoradiotherapy / Q000379:methods; D015331:Cohort Studies; D018572:Disease-Free Survival; D005005:Ethmoid Sinus / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009296:Nasal Cavity / Q000473:pathology*; D009367:Neoplasm Staging / Q000145:classification; D010255:Paranasal Sinus Neoplasms / Q000145:classification* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome