The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8(+) T cell-mediated lysis and continue to produce virus over long periods of time.
Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA.
Lara
L
Vojnov
Mauricio A
MA
Martins
Alexander T
AT
Bean
Marlon G
MG
Veloso de Santana
Jonah B
JB
Sacha
Nancy A
NA
Wilson
Myrna C
MC
Bonaldo
Ricardo
R
Galler
Mario
M
Stevenson
David I
DI
Watkins
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005805:Genes, MHC Class I; D005838:Genotype; D006801:Humans; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology*; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013997:Time Factors; D014779:Virus Replication / Q000276:immunology*