Serum lipid levels and bone mineral density in Greek postmenopausal women.
Contradictory results have been reported regarding a relationship between serum lipid levels and bone mineral density. The purpose of this study was to further investigate a possible relationship between those parameters in Greek postmenopausal women. A total of 591 patients followed at a tertiary hospital were examined for seven different lipid factors in relation to dual-emission X-ray absorptiometry measurements at the lumbar spine. Lipoprotein-a was the only lipid measurement that univariately showed an almost significant trend of association with bone mass category (analysis of variance [ANOVA] p value 0.062 for Ln(Lipoprotein-a)). In multiple regression, it was noted that a non-significant negative trend of association of high density lipoprotein (HDL) cholesterol and Apolipoprotein AI with lumbar T-score (p value 0.058 and 0.075, respectively). In age subgroup analysis, Lipoprotein-a and Ln(Lipoprotein-a) presented a negative correlation with lumbar T-score for women with age ≥ 53 years (p value 0.043 and 0.070, respectively), while a negative correlation of HDL and Apolipoprotein AI levels with lumbar T-score remained in women with age < 53 years (p value 0.039 and 0.052, respectively). The findings do not support a strong relationship between lipid levels and bone mass measurements.
Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece.
Paraskevi
P
Pliatsika
Aris
A
Antoniou
Andreas
A
Alexandrou
Constantinos
C
Panoulis
Evangelia
E
Kouskouni
Areti
A
Augoulea
Spyridon
S
Dendrinos
Leon
L
Aravantinos
Maria
M
Creatsa
Irene
I
Lambrinoudaki
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000375:Aging; D016632:Apolipoprotein A-I / Q000097:blood; D015519:Bone Density; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008499:Medical Records; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D017698:Postmenopause; D012189:Retrospective Studies; D012306:Risk
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008055:Lipids