Copper(I)-amine metallo-organocatalyzed synthesis of carbo- and heterocyclic systems.
The efficient and atom economical synthesis of 5-membered cyclic structures has been achieved through the combination of amino catalysis and metal catalysis. The discovery of a novel metallo-organocatalytic system merging the use of a catalytic copper(I) complex and a catalytic amount of cyclohexylamine allowed the room temperature preparation of a broad range of skeletons such as cyclopentanes, indanes, pyrrolidines and tetrahydrofuran, important structural cores of many biologically relevant molecules. Mechanistic studies were presented.
E.N.S.C.P., Chimie-ParisTech, UMR 7223, Laboratoire Charles Friedel, 75005 Paris, France.
Benjamin
B
Montaignac
Victor
V
Östlund
Maxime R
MR
Vitale
Virgnie
V
Ratovelomanana-Vidal
Véronique
V
Michelet