Experiences of high-dose mizoribine as antimetabolite immunosuppressants for kidney transplantation.
We have used low doses of mizoribine (MZ) or mycophenolate mofetil (MMF) as induction and maintenance immunosuppressants, but since 2009 have employed a high dose of MZ. We reviewed the efficacy and side effects of MZ compared with MMF. It is difficult to compare graft survivals between these periods because of different patient demographics, though the high dose of MZ cohort showed no significant difference from MMF. High doses of MZ serum to prevent acute rejection episodes as the induction and maintenance therapy. MZ controlled with blood concentrations showed less side effects, suggesting that high MZ doses could be safely used for an induction and maintenance antimetabolite.
Department of Urology, Fukuoka University Hospital, Fukuoka, Japan. nobu0149@me.com
N
N
Nakamura
H
H
Mikami
H
H
Matsuoka
S
S
Irie
Y
Y
Abe
Y
Y
Sasatomi
S
S
Ogawara
T
T
Saitoh
M
M
Tanaka
D000293:Adolescent; D000328:Adult; D001739:BK Virus / Q000472:pathogenicity; D002648:Child; D003586:Cytomegalovirus Infections / Q000821:virology; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival / Q000187:drug effects; D006562:Herpes Zoster / Q000821:virology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D007564:Japan; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D027601:Polyomavirus Infections / Q000821:virology; D012189:Retrospective Studies; D012263:Ribonucleosides / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D016896:Treatment Outcome; D055815:Young Adult
D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D009173:Mycophenolic Acid