Behavioral investigation of mice with experimental autoimmune encephalomyelitis.
Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG(35-55) model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG(35-55) are probably subtle or absent.
Laboratório de Imunofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. dhenrodrigues@gmail.com
David Henrique
DH
Rodrigues
Márcia de Carvalho
Mde C
Vilela
Norinne
N
Lacerda-Queiroz
Aline Silva de
AS
Miranda
Larissa Fonseca da Cunha
LF
Sousa
Helton José dos
HJ
Reis
Antônio Lúcio
AL
Teixeira
D000818:Animals; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology*; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL