[Study of protective effects on noise-induced hearing loss using N-acetyl-cysteine].
OBJECTIVE
To evaluate the protective effects of oral administration of N-acetyl-cysteine (NAC) on noise-induced hearing loss.


METHODS
Three hundred sixty three volunteers were recruited and randomly divided into two groups: experimental group (n=223) and control group (n=140). The subjects had received oral administration of NAC in the experimental group and placebo in the control group before noise exposure. The routine audiometric evaluation and ABR testing were performed and recorded pre- and post-noise exposure. The statistical analysis was carried out on the data obtained from two groups with SPSS 11.0.


RESULTS
The hearings of all the participatory were changed after noise exposure, but there were statistically significant differences between two groups.


CONCLUSIONS
The protective effects of NAC were prominent on the noise-induced hearing loss.
Department of Otorhinolaryngology, the 404th Hospital of PLA, Weihai, 264200, China. gezmin@163.com
Zhenmin
Z
Ge
Shu
S
Ma
Xiaoqing
X
Jia
Li
L
Song
D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008889:Military Personnel; D055815:Young Adult
D000111:Acetylcysteine