A long-term follow-up of allergic diseases in Iceland.
BACKGROUND
Allergic disorders are an increasing health problem in many countries, in particular among children. We have evaluated the prevalence and manifestations of allergy in a cohort of young Icelanders for more than two decades. Variations in the epidemiology and clinical expression of allergy in different communities may help to identify etiological factors contributing to these disorders.


METHODS
A cohort of 179 children has been monitored for allergic manifestations for two decades, at the ages of two, four, eight, and 15 years, and most recently at the age of 21 years involving 120 of the participants.


RESULTS
Cumulative prevalences of 40%, 45%, and 29% have been observed, respectively, for rhinoconjunctivitis, eczema, and asthma during the study period. None had developed rhinoconjunctivitis at the age of about 2 years, but the point prevalence gradually increased to 33% at the age of 21 years. Conversely, the prevalence of eczema was 31% at the age of 2 years, but gradually declined to 8% at the age of 21 years. The prevalence of asthma peaked at 28% at the age of 4 years, but declined thereafter and has remained stable at about 13% from the age of eight to 21 years.


CONCLUSIONS
The prevalence of allergic diseases is high in Iceland among children and young individuals. Asthma and atopic eczema are very common in childhood, but decreases with age while the prevalence of rhinoconjunctivitis increases markedly. The very high and increasing prevalence of rhinoconjunctivitis among 15- to 21-year-old individuals is noteworthy.
The Children's Hospital Iceland, Landspítali - University Hospital, Iceland.
Anna Freyja
AF
Finnbogadóttir
Björn
B
Árdal
Herbert
H
Eiríksson
Birgir
B
Hrafnkelsson
Helgi
H
Valdimarsson
Björn Rúnar
BR
Lúðvíksson
Ásgeir
Á
Haraldsson
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D007055:Iceland / Q000453:epidemiology; D007223:Infant; D008297:Male; D015995:Prevalence; D055815:Young Adult