Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats.
The present work was undertaken to evaluate the protective effect of an aqueous extract of green tea (GT, Camellia sinensis) leaves against arsenic (NaAsO₂)-induced biochemical toxicity and lipid peroxidation production in experimental rats. The treatment with arsenic exhibited a significant increase in some serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, albumin, bilirubin, cholesterol, urea and creatinine). But the co-administration of GT has increased the level of plasmatic concentration of biochemical parameters. Exposure of rats to arsenic caused also a significant increase in liver, kidney and testicular thiobarbituric acid reactive substances compared to control. However, the co-administration of GT was effective in reducing its level. To conclude, our data suggest that arsenic exposure enhanced an oxidative stress by disturbing the tissue antioxidant defense system, but the GT co-administration alleviates the toxicity induced by arsenic exposure.
Animal Ecophysiology Laboratory, Faculty of Sciences, Badji Mokhtar University, Algeria. mahfoud.messarah@univ-annaba.org
Mahfoud
M
Messarah
Mongi
M
Saoudi
Amel
A
Boumendjel
Lilia
L
Kadeche
Mohamed Salah
MS
Boulakoud
Abdelfattah
A
El Feki
D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D028241:Camellia sinensis / Q000737:chemistry*; D004906:Erythrocyte Count; D007668:Kidney / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D001798:Blood Proteins; D010936:Plant Extracts; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001151:Arsenic