Calcium phosphate cements as drug delivery materials.
Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions.
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), Av. Diagonal 647, Barcelona, Spain. maria.pau.ginebra@upc.edu
Maria-Pau
MP
Ginebra
Cristina
C
Canal
Montserrat
M
Espanol
David
D
Pastorino
Edgar B
EB
Montufar
D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002130:Calcium Phosphates / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008970:Molecular Weight; D016062:Porosity; D013696:Temperature
D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate