A nebulized intra-tracheal rat model of invasive pulmonary aspergillosis.
Animal models are particularly useful for the study of many infectious diseases, including those caused by fungi. Invasive pulmonary aspergillosis is most frequently studied in mouse models. We present here an animal model of this disease based on undernourished immunocompromised rats infected with Aspergillus fumigatus spores by intra-tracheal nebulisation.
Parasitologie-Mycologie-Médecine tropicale, Centre Hospitalier Régional et Universitaire, Tours, France.
Guillaume
G
Desoubeaux
Jacques
J
Chandenier
D000818:Animals; D001232:Aspergillus fumigatus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D055744:Invasive Pulmonary Aspergillosis / Q000382:microbiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013172:Spores, Fungal / Q000502:physiology; D014132:Trachea / Q000382:microbiology*