[Event-related potentials P(300) with memory function in obstructive sleep apnea syndrome].
OBJECTIVE
To explore the variability of event-related potentials P(300) and memory function in patients with obstructive sleep apnea syndrome(OSAS).


METHODS
Polysomnography (PSG) event-related potentials (ERPs) P(300) and Wechsler Memory Scale (WMS) were detected in 30 subjects with OSAS and 20 normal controls.


RESULTS
The memory quotient [(86 ± 13) scores] in the OSAS group was significantly lower than that in the control group (P < 0.01). The latency of P(300) [(410 ± 80) ms at Cz and (409 ± 80) ms at Pz] in the OSAS group was significantly longer than that in the control group (P < 0.01). In the OSAS group, the latency of P(300) was correlated negatively with the memory quotient and nocturnal hypoxemia, but positively with apea/hypopnea index (AHI, P < 0.01).


CONCLUSIONS
OSAS has memory deficit, which can be evaluated comprehensively by P(300) and WMS. The longer latency of P(300) might be regarded as one of the electrophysiological markers to indicate the severity of cognition in OSAS. Recurrent attacks of nocturnal intermittent hypoxemia may cause the regional brain damage related to cognition defect.
Department of Respiratory Medicine, the First Affiliated Hospital, College of Medical, Zhejiang University, Hangzhou 310003, China.
Zhi-jie
ZJ
Pan
Wei-bo
WB
Liu
Ling-ju
LJ
Zhang
Pan-feng
PF
Xu
Jian-ying
JY
Zhou
D000328:Adult; D016022:Case-Control Studies; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000523:psychology*