Serum ischemia modified albumin levels in pregnancies with neural tube defects.
OBJECTIVE
To evaluate ischemia-modified albumin (IMA) in women who had been pregnant with a child suffering from neural tube defect.


METHODS
Samples from 50 women who had been pregnant with an affected child (25 spina bifida, 25 anencephaly) and 25 controls matched for age, gestational age, and body mass index were studied. We measured serum IMA by enzyme-linked immunosorbent assay.


RESULTS
Serum IMA was significantly higher in the study group compared to normal pregnancies (p < 0.05). The area under the receiver operating curve was 0.858 for IMA (95% CI, 0.769-0.947), whereas the optimal threshold value of IMA to discriminate between affected children and controls was 0.409 (sensitivity 88%, specificity 80%). The risk for increased IMA in mothers who have conceived a fetus with neural tube defect is 24.5 times higher than in the control group (rr = 24.5, 6.9-86.9, 95% CI) (p = 0.001).


CONCLUSIONS
This study indicates that serum IMA in women who have conceived a fetus with neural tube defect is significantly higher than that in normal pregnant women.
Department of Radiology, Antakya Government Hospital, Ankara, Turkey.
Ismail
I
Güzelmansur
Yusuf
Y
Ustün
Yaprak
Y
Engin-Ustün
Ozlem
O
Oztürk
Halil
H
Yaman
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood*; D009436:Neural Tube Defects / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood*; D012016:Reference Values; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D016135:Spinal Dysraphism / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human