Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors.
OBJECTIVE
We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression.


METHODS
Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT).


RESULTS
In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients.


CONCLUSIONS
Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB.
Hematology-Oncology Unit, First Department of Pediatrics, University of Athens, Athens, Greece.
Maria
M
Moschovi
Eleutheria
E
Koultouki
Kalliopi
K
Stefanaki
George
G
Sfakianos
Natalia
N
Tourkantoni
Neofytos
N
Prodromou
George A
GA
Alexiou
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D003388:Cranial Fossa, Posterior / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism* / Q000401:mortality; D008565:Membrane Proteins / Q000096:biosynthesis*; D015999:Multivariate Analysis; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D018335:Rhabdoid Tumor / Q000378:metabolism* / Q000401:mortality; D019292:Skull Base Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; C406887:IFI27 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53