The association between fat and lean mass and bone mineral density: the Healthy Twin Study.
The potential beneficial effects of increased body weight on bone mineral density (BMD) conflict with the adverse effects of obesity on various health outcomes, necessitating more specific evaluations of the association between each body component and BMD. In the present study, we evaluated associations of lean mass (LM) and fat mass (FM) with BMD in a Korean sample consisting of a total of 1782 men and women whose mean (standard deviation) age was 43.2 (12.6) years. They were selected from the Healthy Twin Study, a nationwide Korean twin and family study. BMD, FM and LM were measured using dual-energy X-ray absorptiometry. Quantitative genetic analysis and linear mixed analysis were performed with respect to familial relationships and a wide range of probable covariates. Linear mixed analysis revealed that BMD was positively associated with both FM and LM at each region of BMD measurement (whole body, spine, arms, and legs) in men, premenopausal women, and postmenopausal women. However, the association with BMD was stronger for LM than FM. Both LM and FM had positive genetic correlations with BMD at each region, although the correlation with BMD tended to be stronger for LM than FM. Together, these findings suggest that increased LM, rather than FM, is more beneficial for BMD in the Korean population and warrants further study of the common genetic determinants of BMD and body composition.
Health Care Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Joo-Hyun
JH
Park
Yun-Mi
YM
Song
Joohon
J
Sung
Kayoung
K
Lee
Youn Sic
YS
Kim
Taehun
T
Kim
Sung-Il
SI
Cho
D050154:Adiposity / Q000502:physiology*; D000328:Adult; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000503:physiopathology*; D013851:Thinness / Q000503:physiopathology*