Neurodevelopmental functioning in very young children undergoing treatment for non-CNS cancers.
OBJECTIVE
We initiated a prospective study of very young children with cancer, in comparison with matched healthy children, to investigate neurodevelopmental consequences of non-CNS cancers and treatment.


METHODS
A total of 61 children (≤42 months) with non-CNS cancers and 61 matched controls underwent an identical age-appropriate neuropsychological test battery.


RESULTS
Children with cancer manifested deficits compared to healthy controls in motor, mental, and language development, but were similar to controls in cognitive representational abilities and emotional relationships in interaction with their mothers. Better physician-rated health status at diagnosis and mother-rated behavioral status 1 month prior to assessment were associated with better motor and mental performance in the cancer group.


CONCLUSIONS
This study identifies deficits as well as spared functions in children with non-CNS cancers; the results suggest ways parents and healthcare professionals may plan specific remediations to enhance quality of life in young cancer survivors.
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Marc_H_Bornstein@nih.gov
Marc H
MH
Bornstein
Sara
S
Scrimin
Diane L
DL
Putnick
Fabia
F
Capello
O Maurice
OM
Haynes
Simona
S
de Falco
Modesto
M
Carli
Marta
M
Pillon
D000328:Adult; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000523:psychology; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D017567:Karnofsky Performance Status; D007804:Language Development; D008297:Male; D009035:Mothers / Q000523:psychology; D009369:Neoplasms / Q000150:complications / Q000523:psychology*; D009483:Neuropsychological Tests; D011446:Prospective Studies