Non-hispanic whites have higher risk for pulmonary impairment from pulmonary tuberculosis.
BACKGROUND
Disparities in outcomes associated with race and ethnicity are well documented for many diseases and patient populations. Tuberculosis (TB) disproportionately affects economically disadvantaged, racial and ethnic minority populations. Pulmonary impairment after tuberculosis (PIAT) contributes heavily to the societal burden of TB. Individual impacts associated with PIAT may vary by race/ethnicity or socioeconomic status.


METHODS
We analyzed the pulmonary function of 320 prospectively identified patients with pulmonary tuberculosis who had completed at least 20 weeks standard anti-TB regimes by directly observed therapy. We compared frequency and severity of spirometry-defined PIAT in groups stratified by demographics, pulmonary risk factors, and race/ethnicity, and examined clinical correlates to pulmonary function deficits.


RESULTS
Pulmonary impairment after tuberculosis was identified in 71% of non-Hispanic Whites, 58% of non-Hispanic Blacks, 49% of Asians and 32% of Hispanics (p < 0.001). Predictors for PIAT varied between race/ethnicity. PIAT was evenly distributed across all levels of socioeconomic status suggesting that PIAT and socioeconomic status are not related. PIAT and its severity were significantly associated with abnormal chest x-ray, p < 0.0001. There was no association between race/ethnicity and time to beginning TB treatment, p = 0.978.


CONCLUSIONS
Despite controlling for cigarette smoking, socioeconomic status and time to beginning TB treatment, non-Hispanic White race/ethnicity remained an independent predictor for disproportionately frequent and severe pulmonary impairment after tuberculosis relative to other race/ethnic groups. Since race/ethnicity was self reported and that race is not a biological construct: these findings must be interpreted with caution. However, because race/ethnicity is a proxy for several other unmeasured host, pathogen or environment factors that may contribute to disparate health outcomes, these results are meant to suggest hypotheses for further research.
Department of Internal Medicine, UNT- Health Science Center at Fort Worth, Fort Worth, TX, USA.
Jotam G
JG
Pasipanodya
Edgar
E
Vecino
Thaddeus L
TL
Miller
Guadalupe
G
Munguia
Gerry
G
Drewyer
Michel
M
Fernandez
Philip
P
Slocum
Stephen E
SE
Weis
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D055370:Lung Injury / Q000208:ethnology / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012129:Respiratory Function Tests; D018570:Risk Assessment; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000208:ethnology; D044465:White People