Boronate-mediated biologic delivery.
Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Gregory A
GA
Ellis
Michael J
MJ
Palte
Ronald T
RT
Raines
D000818:Animals; D001897:Boronic Acids / Q000737:chemistry* / Q000378:metabolism; D016466:CHO Cells; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D020014:K562 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*
D001897:Boronic Acids; D004337:Drug Carriers; D012259:Ribonuclease, Pancreatic