Chronic pancreatitis in India and Asia.
Chronic pancreatitis (CP) is widely prevalent in Asian countries much more so in India and Japan. The phenotype of CP is somewhat similar to that reported from western countries. The prevalent types of CP are mainly idiopathic and alcohol related. Current evidence suggests that the term "tropical pancreatitis" used for idiopathic CP from India is a misnomer. Gallstones' association with CP reported from China remains controversial. There has been ample evidence that mutations in the SPNIK1 and CFTR genes are strongly associated with idiopathic CP in patients from different ethnic backgrounds. Oxidative stress is important in the pathophysiology and antioxidants have been shown to result in significant pain relief with CP. Home-made balanced diet is effective for treating malnutrition in patients with CP. Endoscopic therapy combined with ESWL may provide significant relief in patients with pancreatic ductal calculi/stricture. Surgery is quite effective in CP and may be better than endotherapy.
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, 110029, India. pkgarg@aiims.ac.in
Pramod Kumar
PK
Garg
D001208:Asia / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D009154:Mutation; D050500:Pancreatitis, Chronic / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics / Q000628:therapy; D015995:Prevalence