[Hemodynamic disorders and myocrdial insufficiency after toxic doses of propranolol].
Results of an experimental study of the toxic action of propranolol on the cardiovascular system are presented. It was shown that i/p injections of propranolol (2 mg/100 g) cause circulatory insufficiency, activate free radical oxidation, and induce cardiac dysfunction.
B B
BB
Iatsiniuk
V T
VT
Dolgikh
V G
VG
Sentsov
S Iu
SIu
Medvedeva
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D002496:Central Venous Pressure / Q000187:drug effects*; D054796:Drug Dosage Calculations; D004562:Electrocardiography / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008991:Monitoring, Physiologic / Q000379:methods; D018384:Oxidative Stress / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D014116:Toxicology / Q000379:methods
D000319:Adrenergic beta-Antagonists; D011433:Propranolol