Fast and pH-dependent release of domperidone from orally disintegrating tablets.
There has been growing interest in orally disintegrating tablets (ODTs) during the last decade due to their better patient acceptance and compliance. Further, drug dissolution and absorption may be significantly improved. This work describes the preparation of fast and pH-dependent release ODTs for domperidone by direct compression using crospovidone as superdisintegrant. Solid dispersions of domperidone and Eudragit L100-55, at different weight ratios, were prepared and characterized by DSC, TGA, X-ray diffraction, and FTIR, which indicated the presence of drug-polymer interaction. Disintegration time, friability, and hardness of ODTs were evaluated. In vitro drug release in 0.1N HCl and in phosphate buffer (pH 5.8 and 6.8) was investigated. All domperidone ODTs had fast disintegration times (6 KP) and acceptable friability (<1%). Drug release from fast release ODTs was highly improved; reaching 97% after 10 min in 0.1N HCl, compared to the dissolution of the free drug. Drug release from solid dispersions was pH dependent; showing higher release rates at pH 6.8 than at lower pH values. The controlled-release ODT resulted in 47% drug release in 0.1N HCl, with the rest of drug released at pH 6.8. Domperidone ODTs were considered suitable for ODT formulation.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. sheassaf@just.edu.jo
Shereen M
SM
Assaf
Amjad M
AM
Qandil
Enas A
EA
Al-Ani
D000180:Acrylic Resins / Q000737:chemistry*; D000284:Administration, Oral; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004294:Domperidone / Q000008:administration & dosage / Q000737:chemistry*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D006863:Hydrogen-Ion Concentration; D011205:Povidone / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013818:Thermogravimetry; D013997:Time Factors
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D018492:Dopamine Antagonists; C446821:Eudragit L100-55; D005079:Excipients; D013607:Tablets; D004294:Domperidone; D011205:Povidone