2-Aminopyrimidine as a novel scaffold for biofilm modulation.
An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of these new derivatives and that of the 2-aminoimidazole class of anti-biofilm compounds. Several derivatives displayed the ability to modulate bacterial biofilm formation, exhibiting greater activity against Gram-positive strains than Gram-negative strains. Additionally some 2-aminopyrmidines were able to suppress MRSA resistance to conventional antibiotics.
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Erick A
EA
Lindsey
Roberta J
RJ
Worthington
Cristina
C
Alcaraz
Christian
C
Melander
D018441:Biofilms; D006860:Hydrogen Bonding; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011743:Pyrimidines; C012180:2-aminopyrimidine