[Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets].
OBJECTIVE
To prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.


METHODS
The core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.


RESULTS
About 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.


CONCLUSIONS
Pae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.
Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
Tongyan
T
Wang
Qihua
Q
Cui
Qingri
Q
Cao
Jinghao
J
Cui
D000098:Acetophenones / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003106:Colon / Q000187:drug effects*; D016503:Drug Delivery Systems / Q000379:methods*; D005079:Excipients / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D013608:Tablets, Enteric-Coated / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000098:Acetophenones; D005079:Excipients; D013608:Tablets, Enteric-Coated; D047392:beta-Cyclodextrins; C013638:paeonol