Apolar carbohydrates as DNA capping agents.
Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C-G base pairs. Here we present an apolar version of glucose and cellobiose as new capping agents that stack on DNA increasing considerably its stability with respect to their natural polyhydroxylated mono- and disaccharide DNA conjugates.
Instituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain.
Ricardo
R
Lucas
Empar
E
Vengut-Climent
Irene
I
Gómez-Pinto
Anna
A
Aviñó
Ramón
R
Eritja
Carlos
C
González
Juan C
JC
Morales
D020029:Base Pairing; D002475:Cellobiose / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D015394:Molecular Structure; D013816:Thermodynamics
D002475:Cellobiose; D004247:DNA; D005947:Glucose