Syntheses and properties of trimethylaminophenoxy-substituted Zn((II))-phthalocyanines.
The syntheses, photophysical properties and in vitro biological behavior of a series of nine Zn((II))-phthalocyanines (ZnPcs) bearing one to eight positively-charged trimethylaminophenoxy groups are reported. All ZnPcs are highly soluble in polar organic solvents, and show fluorescence and singlet oxygen quantum yields in the ranges 0.11-0.21 and 0.16-0.47, respectively. The cytotoxicity of the ZnPcs depends on both the number of charges and their site of substitution (α vs. β) on the Pc isoindole units; the most promising for PDT application are the α-substituted di-cationic ZnPcs 6a and 17a.
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Benson G
BG
Ongarora
Xiaoke
X
Hu
Hairong
H
Li
Frank R
FR
Fronczek
M Graça H
MG
Vicente