Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
L
L
Guandalini
E
E
Martini
L
L
Di Cesare Mannelli
S
S
Dei
D
D
Manetti
S
S
Scapecchi
E
E
Teodori
C
C
Ghelardini
M N
MN
Romanelli
D000759:Adjuvants, Anesthesia; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D015195:Drug Design; D051379:Mice; D018697:Nootropic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D012601:Scopolamine; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
D000759:Adjuvants, Anesthesia; D018697:Nootropic Agents; D010879:Piperazines; D013449:Sulfonamides; C545789:sapunifiram; C416655:DM 235; D012601:Scopolamine