[Usefulness of examinations of serum levels of matrix metalloproteinases 1, MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1, hyaluronic acid and antibodies against cyclic citrullinated peptide in Lyme arthritis, rheumatoid arthritis and patients with arthritic complaints].
Lyme disease is a multisystem disease that can affect skin, nervous system, heart and joints. Lyme arthritis can develope in about 60% of "not treated" Lyme disease patients, 10% of patients may develope chronic arthritis. Lyme arhritis symptoms (especially chronic arthritis) is similar to rheumatoid arthritis. The purpose of this study was to establish the usefulness of examinations of serum levels of matrix metalloproteinases MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1 (TIMP-1), hialuronic acid (HA) and antibodies against cyclic citrullinated peptide (anti-CCP) in Lyme arthritis, rheumatoid arthritis (RA) and patients with arthritic complaints. Plasma levels of MMP-3, HA and anti-CCP were significantly higher in RA group than in Lyme arthritis group and patients with arthritic complaints. There were no significant differences in serum levels of MMP-3, MMP-9, TIMP-1, HA, anti-CCP between Lyme arthritis patients and patients with arthritic complaints and these parameters are not usefull in differential diagnoses of Lyme arthritis.
Wojewódzki Szpital Specjalistyczny im. K. Dłuskiego.
Anna
A
Czeczuga
Joanna
J
Zajkowska
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008193:Lyme Disease / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology*; D020781:Matrix Metalloproteinase 1 / Q000097:blood; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D020782:Matrix Metalloproteinases / Q000097:blood; D010456:Peptides, Cyclic / Q000097:blood*; D011044:Poland; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
D010456:Peptides, Cyclic; D019715:Tissue Inhibitor of Metalloproteinase-1; C487763:cyclic citrullinated peptide; D006820:Hyaluronic Acid; D020782:Matrix Metalloproteinases; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1