Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum.
One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7alpha,8beta-dihydroxydeepoxysarcophine (2), 7beta-acetoxy-8alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 microg/mL, respectively.
Chemistry of Medicinal Plants Department, National Research Centre, Dokki, Giza 12622, Egypt.
Mohamed-Elamir F
ME
Hegazy
Ahmed A
AA
El-Beih
Alaa Y
AY
Moustafa
Abdelhamed A
AA
Hamdy
Montaser A
MA
Alhammady
Rehab M
RM
Selim
Mohamed
M
Abdel-Rehim
Paul W
PW
Paré
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation
D000970:Antineoplastic Agents; D004224:Diterpenes