Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis.
Three new biflavonoids, wikstaiwanones A-C (1-3), along with four known compounds (4-7) were isolated from the stems of Wikstroemia taiwanensis (Thymelaeaceae). Their structures were elucidated by spectroscopic analysis. Compounds 4 and 5 showed antitubercular activity against Mycobacterium tuberculosis with MIC values of 15 μg/mL, respectively.
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan.
Li-Yin
LY
Chen
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ih-Sheng
IS
Chen
Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chien-Fang
CF
Peng
D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry* / Q000378:metabolism; D032365:Wikstroemia / Q000737:chemistry* / Q000378:metabolism
D000995:Antitubercular Agents; D044946:Biflavonoids