Varying presentations in patients with symptomatic type IV vascular Ehlers-Danlos syndrome.
Ehlers-Danlos syndrome (EDS) represents a group of inheritable connective tissue disorders. Patients with type IV or vascular EDS, autosomal dominant pattern of inheritance, may present with aneurysm formation or arterial dissection. Due to vessel fragility, operative therapy for such disorders has been reserved for compelling indications in which benefit clearly warrants risk, yet assessment of risk is largely clinical with operative decisions guided by factors such as response to previous operations and age at onset of index vascular complications. We present 2 patients with differences in their clinical presentations and outcomes and review the literature with emphasis on operative decision making.
Department of Surgery, University of Louisville, Louisville, KY 40202, USA. amitdwivedi@gmail.com
Amit J
AJ
Dwivedi
Omar
O
Hamdallah
Marvin E
ME
Morris
Andrea E
AE
Yancey
Charles B
CB
Ross
D000328:Adult; D000784:Aortic Dissection / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D016893:Carotid Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004535:Ehlers-Danlos Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D017809:Fatal Outcome; D006801:Humans; D017543:Iliac Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex