Evaluation of n-butyl cyanoacrylate adhesive in rat subcutaneous tissue.
BACKGROUND
Tissue adhesives have been widely used for wound closure, especially in children, because they are painless, fast, and easy to use and result in minimal scarring.


OBJECTIVE
To analyze the biocompatibility of an adhesive based on n-butyl-cyanoacrylate in the subcutaneous tissue of rats.


METHODS
Two surgical sites were prepared (approximately 3 cm apart): one on the left side of the animal and the other on the right side); polyethylene tubes were implanted in each surgical site. The tube on the left was filled with n-butyl-cyanoacrylate (treated group) and the tube on the right side was unfilled (control group). After 7, 30, and 120 days, the animals were killed, and the specimens were processed for histologic analysis.


RESULTS
No significant inflammatory reaction occurred in the treated group, showing results similar to the control group.


CONCLUSIONS
This adhesive based on n-butyl-cyanoacrylate is biocompatible in the subcutaneous tissue of rats.
Department of Morphology, Dental of School at Araraquara, Araraquara, São Paulo, Brazil. leticiabmestieri@foar.unesp.br
Leticia Boldrin
LB
Mestieri
Sybele
S
Saska
Raul García
RG
Carrodeguas
Ana Maria Minarelli
AM
Gaspar
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D004659:Enbucrilate / Q000494:pharmacology*; D008422:Materials Testing; D051381:Rats; D040521:Subcutaneous Tissue / Q000187:drug effects* / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D004659:Enbucrilate