Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction.
This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.
The Pennsylvania State University, 104 Chemistry Bldg., University Park, PA 16803, USA.
Hemakesh
H
Mohapatra
Kyle M
KM
Schmid
Scott T
ST
Phillips