Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma.
C-reactive protein (CRP) is an acute-phase reactant that is a promising biomarker in patients with cancer of many kinds. The aim of this retrospective study was to evaluate significant changes in CRP levels as a parameter for the response effect and long-term survival of patients with diffuse large B cell lymphoma (DLBCL). Serum CRP data were collected in 94 patients with DLBCL from October 2006 to August 2009 in Cancer Center, Sun Yat-Sen University. Results were correlated with clinical data. The median CRP serum level in patients with DLBCL was 30.91 ± 53.35 in male and 22.39 ± 29.89 mg/L in female. Base line CRP levels were correlated with International Prognostic Index (IPI) scores (p = 0.03). Among the patients with an IPI score of 1-2, base line CRP levels were correlated with long-term survival (p = 0.001). Base line CRP levels were also correlated with OS (p = 0.001) and varied with different clinical stages (p = 0.03). The corresponding CRP levels in the patients with 2 cycles of chemotherapy were correlated with short-term treatment response (p = 0.003) and OS (p = 0.04) or TTP (p = 0.03). CRP serum levels can be used as additional prognostic parameter in patients with diffuse large B cell type lymphoma.
State Key Laboratory of Oncology, South China, Guangzhou, Guangdong 510060, People's Republic of China.
Ye
Y
Cao
Yan-xia
YX
Shi
Jing-ou
JO
Chen
Yu-ting
YT
Tan
Yu-Chen
YC
Cai
Hui-yan
HY
Luo
Miao-zhen
MZ
Qiu
Xiu-yu
XY
Cai
Ying
Y
Jin
Yue-li
YL
Sun
Wen-qi
WQ
Jiang
D000209:Acute-Phase Proteins / Q000378:metabolism; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
D000209:Acute-Phase Proteins; D014408:Biomarkers, Tumor; D002097:C-Reactive Protein