Uterine leiomyosarcoma producing granulocyte colony stimulating factor.
Uterine leiomyosarcoma associated with the paraneoplastic production of granulocyte-colony stimulating factor (GCSF) is extremely rare. No case has been reported to date in the English literature. We describe a case of a 56-year-old female with recurrent uterin leiomyosarcoma, associated with leukocytosis (19100/mm) and an elevated serum GCSF (33.0 pg/ml). Tumore histology was consistent with a well differentiated leiomyosarcoma with marked neutrophilic infiltration of the lung and spleen metastases. tumor cells were distinctly positive for GCSF on immunohistochemistry. These findings confirmed the diagnosis of a GCSF-producting uterine leiomyosarcoma with a paraneoplastic leukocytosis.
Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan. kn88@med.shimane-u.ac.jp
Kentaro
K
Nakayama
Naomi
N
Nakayama
Mohammed Tanjimur
MT
Rahman
Munmun
M
Rahman
Hiroshi
H
Katagiri
Atsuko
A
Katagiri
Masako
M
Ishikawa
Tomoka
T
Ishibashi
Kouji
K
Iida
Yuji
Y
Harada
Kohji
K
Miyazaki
D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007890:Leiomyosarcoma / Q000378:metabolism* / Q000556:secondary; D007964:Leukocytosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000150:complications*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor