Therapeutic potential of marine n-3 fatty acids in CABG patients.
Dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) has beneficial effects in various cardiac disorders. Few studies have, however, investigated the therapeutic potential of n-3 PUFA in patients undergoing coronary artery bypass grafting (CABG). Five heterogeneous randomized studies on n-3 PUFA for prevention of postoperative atrial fibrillation have yielded conflicting results. Increased venous graft patency rates following CABG were seen in another study in patients treated with n-3 PUFA. Finally, supplements with n-3 PUFA postoperatively have been associated with a lower risk of repeat revascularization and lower mortality in patients with poor ventricular function. Data are still few, and more studies are needed to clarify the therapeutic potential of n-3 PUFA in patients undergoing CABG.
Department of Cardiothoracic Surgery, Center for Cardiovascular Research, Aalborg Hospital, Aalborg, Denmark. jan.jesper.andreasen@stofanet.dk
Jan Jesper
JJ
Andreasen
Erik Berg
EB
Schmidt
D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005395:Fish Oils; D006801:Humans; D014654:Vascular Patency / Q000187:drug effects
D002316:Cardiotonic Agents; D015525:Fatty Acids, Omega-3; D005395:Fish Oils