IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE.
Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE. While IgM are often considered polyreactive, we postulate that there are distinct sets of IgM-autoantibodies of defined autoreactive specificities relevant to different features of SLE. We examined the relationships between levels of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients. IgM anti-PC was significantly higher in patients with low disease activity and less organ damage determined by the SELENA-SLEDAI, the physician's evaluation and the SLICC damage score. Furthermore, IgM anti-PC was significantly higher in patients without cardiovascular events. In contrast, IgM anti-cardiolipin and IgM anti-dsDNA were significantly higher in patients without renal disease. These results support the hypothesis that some IgM autoantibodies are part of a natural immune repertoire that provide homeostatic functions and protection from certain clinical lupus features.
Department of Medicine, NYU School of Medicine, New York, NY 10016, USA.
Caroline
C
Grönwall
Ehtisham
E
Akhter
Cheongeun
C
Oh
Rufus W
RW
Burlingame
Michelle
M
Petri
Gregg J
GJ
Silverman
D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D017209:Apoptosis; D001323:Autoantibodies / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008297:Male; D008315:Malondialdehyde / Q000276:immunology; D008875:Middle Aged; D010767:Phosphorylcholine / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001323:Autoantibodies; C044203:anti-IgM; D010767:Phosphorylcholine; D008315:Malondialdehyde