Lipids as conductors in the orchestra of life.
The lipid phosphatidic acid is an important metabolic intermediate in the biosynthesis of lipids in all eukaryotic cells, but it is even more than that. Phosphatidic acid is emerging as a lipid that is both composer and conductor, where in addition to its role as biosynthetic precursor (composer) it is also a potent signaling molecule (conductor) that integrates membrane biogenesis with nutrient sensing and cell growth. This article discusses recent advances in yeast that give praise for phosphatidic acid as one of life's conductors.
Department of Cellular and Physiological Sciences, Life Sciences Institute, The University of British Columbia 2350 Health Sciences Mall, Vancouver, British Columbia, Canada, V6T 1Z3.
Christopher J R
CJ
Loewen