Antigen-pulsed dendritic cell approach to melanoma.
Dendritic cells (DCs) are potent antigen-presenting cells (1) with wide tissue distribution. They are classified based primarily on their localization: as Langerhans cells when present in the epidermis and as dermal DCs when found in the dermis. DCs exhibit several common features: an irregular shape with elongated dendritic processes, a distinctive cell-surface phenotype, low buoyant density, active motility, and the ability to stimulate vigorous proliferation of unprimed T-cells. DCs are able to ingest, process, and present antigen in the context of major histocompatibility complex (MHC) molecules. However, because of their high expression of MHC class I and II, as well as costimulatory molecules and adhesion molecules, DCs have the ability to induce primary T-cell-dependent immune responses in vivo and in vitro. This outstanding feature gives DCs a central role in controlling adaptive T-cell-based immunity.
Department of Dermatology, University of Zurich Medical School, Zurich, Switzerland.
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Nestle
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Tun-Kyi
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Gilliet