Autoregulatory model comparison and optimisation methodology.
Cerebral pressure autoregulation (AR) is a process by which blood flow is kept constant over a specific cerebral perfusion pressure (CPP) range. There have been a number of advances in recent years in the monitoring and modelling of this physiological variable; however, there has been very little work done on the comparison or optimisation of some of the existing models in clinical use today: pressure reactivity index, highest modal frequency techniques and compartmental modelling. Presented here is a methodology for the comparison and optimisation results for these main AR models. By simple mathematical manipulation of the original modelling end points each model can be converted into a form that is directly comparable to the others. Using a standardised data set with known gold standard AR status indications, the models can then be readily assessed. As a consequence each of the models can then be optimised to maximise specificity and sensitivity.
Department of Clinical Physics, Institute of Neurological Sciences, Glasgow, Scotland, UK. martin.shaw@nhs.net
Martin
M
Shaw
Ian
I
Piper
Michael
M
Daley
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006706:Homeostasis; D023421:Models, Animal; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D013552:Swine