Functional mannose-binding lectin levels in patients with end-stage renal disease on maintenance hemodialysis.
BACKGROUND
Innate immunity is generally impaired in chronic renal failure (CRF). Mannose-binding lectin (MBL) has an important role in first-line host defense against pathogens via the lectin pathway. We recently reported that functional MBL was significantly lower in CRF patients than in healthy subjects. In this study, we aimed to determine whether functional MBL would be improved following hemodialysis (HD) therapy.


METHODS
This study included 22 patients with end-stage renal disease (ESRD) on maintenance HD. Functional MBL was measured every 6 months for 1 year after HD using an enzyme-linked immunosorbent assay.


RESULTS
Median serum functional MBL levels of ESRD patients were significantly higher after 6 and 12 months than at the start of HD therapy (p < 0.05 and p < 0.01, respectively). Furthermore, median functional MBL levels at 12 months were significantly higher than those at 6 months (p < 0.05).


CONCLUSIONS
We found significant increases in serum functional MBL levels in patients on HD. Our results indicated that HD tailored to remove uremic toxins could improve functional MBL levels in these patients.
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan. satomura.atsushi@nihon-u.ac.jp
Atsushi
A
Satomura
Takayuki
T
Fujita
Mitsuru
M
Yanai
Kazunari
K
Kumasaka
Yuki
Y
Uehara
Kazuyoshi
K
Okada
Yoshinobu
Y
Fuke
Tomohiro
T
Nakayama
D000368:Aged; D048909:Diabetes Complications / Q000097:blood / Q000276:immunology* / Q000628:therapy; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology* / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007113:Immunity, Innate; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000628:therapy; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D057285:Precision Medicine / Q000379:methods; D006435:Renal Dialysis
D037601:Mannose-Binding Lectin