How changes in cell mechanical properties induce cancerous behavior.
Tumor growth and metastasis are ultimately mechanical processes involving cell migration and uncontrolled division. Using a 3D discrete model of cells, we show that increased compliance as observed for cancer cells causes them to grow at a much faster rate compared to surrounding healthy cells. We also show how changes in intercellular binding influence tumor malignancy and metastatic potential. These findings suggest that changes in the mechanical properties of cancer cells is the proximate cause of uncontrolled division and migration and various biochemical factors drive cancer progression via this mechanism.
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Parag
P
Katira
Muhammad H
MH
Zaman
Roger T
RT
Bonnecaze
D002465:Cell Movement; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D013314:Stress, Mechanical