Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010.
In pre- and post-immunisation sera from children (17-120 months-old) and adults (20-59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility and vaccine-induced cross-reactive antibodies to a representative swine H3N2 (swH3N2) and a related ancestral human H3N2 (A/Sydney/5/1997) influenza virus. Few children but a greater proportion of adults showed pre-immunisation haemagglutination inhibition titres ≥40 to either virus. Titres increased with age among children but decreased in adults. Fewer than 20% showed a four-fold rise in antibody titres to either virus following immunisation. Further investigation is warranted to guide ongoing risk assessment and response to emerging swine H3N2 viruses.
British Columbia Centre for Disease Control, Vancouver, Canada. danuta.skowronski@@bccdc.ca
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Skowronski
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De Serres
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Janjua
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Gardy
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Gilca
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Dionne
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Hamelin
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Rhéaume
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Boivin
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000378:metabolism*; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D013552:Swine; D015164:Vaccines, Inactivated / Q000276:immunology / Q000627:therapeutic use; D055815:Young Adult
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated