Hyperandrogenism in a set of triplets with modification of clinical course by hyperthyroidism.
We report hyperandrogenism with severe acne, hirsutism and alopecia in a set of non-obese triplet sisters presenting at an early age. Interestingly, one of the triplets had hyperthyroidism and had significantly lower androgen level as well as hirsutism compared to her sisters. Treatment of hyperthyroidism with radioiodine ablation led to significant elevation of androgen levels and worsening of hirsutism suggesting that hyperthyroidism masks the biochemical and clinical expression of hyperandrogenism in susceptible females.
Department of Pediatrics, Division of Pediatric Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
Vandana
V
Jain
Ming
M
Chen
D000728:Androgens / Q000172:deficiency; D002648:Child; D005260:Female; D006628:Hirsutism / Q000209:etiology / Q000235:genetics / Q000628:therapy; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications* / Q000235:genetics* / Q000628:therapy; D006980:Hyperthyroidism / Q000150:complications* / Q000235:genetics* / Q000532:radiotherapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D035781:Siblings; D014310:Triplets
D000728:Androgens; D007457:Iodine Radioisotopes