Two-component in situ forming supramolecular hydrogels as advanced biomaterials in vitreous body surgery.
Polymeric β-CD and poly{(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt)-co-[6-(acrylamido)-N-adamantylhexaneamide]} are synthesized to build in situ forming hydrogels based on host/guest interactions, so called physical hydrogels. The use of these hydrogels as a potential vitreous body substitute is discussed and recommended. Potential changes in cell morphology and cell vitality of the retinal ganglion cell line RGC-5 are determined. DSC experiments with artificial membrane structures are performed. The analyses show that β-CD overrides the harmful effects of the highly toxic adamantyl-modified polymer. Although the final hydrogel is considered to be biocompatible, the application as a biomaterial has to be reconsidered.
Institute of Organic Chemistry and Macromolecular Chemistry II, Heinrich-Heine-University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Indra
I
Böhm
Falko
F
Strotmann
Carsten
C
Koopmans
Isabel
I
Wolf
Hans-Joachim
HJ
Galla
Helmut
H
Ritter
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020100:Hydrogels; D008567:Membranes, Artificial; D008858:Microscopy, Phase-Contrast; D051381:Rats; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering; D014783:Viscosity; D014822:Vitreous Body / Q000601:surgery; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000180:Acrylic Resins; D001672:Biocompatible Materials; D020100:Hydrogels; D008567:Membranes, Artificial; D047392:beta-Cyclodextrins; C574087:poly((2-acrylamido-2-methyl-1-propanesulfonic acid)-co-(6-(acrylamido)-N-adamantylhexaneamide)); C031215:betadex