Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against HL-60 cells.
Five xanthones, 1,4,5,6-tetrahydroxyxanthone (1) and bracteaxanthones III-VI (2-5) together with twenty-six known compounds (6-31), were isolated from the ethanol extract of the stem bark of Garcinia bracteata. Their structures were elucidated via spectroscopic analyses. Growth inhibitory activities of these compounds against the human leukaemic HL-60 cell line were measured in vitro. Compounds 7, 11, and 29 exhibited moderate activities with GI(50) values of 2.8, 3.4, and 3.1 μM, respectively, and a preliminary structure-activity relationship is discussed.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Sheng-Li
SL
Niu
Zhan-Lin
ZL
Li
Feng
F
Ji
Gu-Yue
GY
Liu
Nan
N
Zhao
Xiao-Qiu
XQ
Liu
Yong-Kui
YK
Jing
Hui-Ming
HM
Hua
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones