Up-front neck dissection followed by concurrent chemoradiation in patients with regionally advanced head and neck cancer.
BACKGROUND
The appropriate management of the neck in patients with regionally advanced head and neck cancer remains controversial. The purpose of this study was to retrospectively analyze our institutional experience with up-front neck dissection followed by definitive chemoradiotherapy.


METHODS
Fifty-five patients with radiographic evidence of large or necrotic lymph nodes underwent up-front neck dissection followed by definitive chemoradiation.


RESULTS
The 5-year overall survival (OS) and progression-free survival (PFS) rates were estimated at 71.3% and 64.7%, respectively. There were 2 failures in the dissected neck, for a control rate of 96.7%. There were 7 locoregional failures and 12 distant failures, for locoregional and distant control rates of 87.3% and 78.2%, respectively.


CONCLUSIONS
Up-front neck dissection followed by chemoradiotherapy resulted in excellent locoregional control, OS, and PFS. Utilization of this strategy should be considered in carefully selected patients with regionally advanced head and neck cancer. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
Department of Radiation Oncology, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA. ppaximad@med.wayne.edu
Peter A
PA
Paximadis
Michael E
ME
Christensen
Greg
G
Dyson
Dev P
DP
Kamdar
Ammar
A
Sukari
Ho-Sheng
HS
Lin
George H
GH
Yoo
Harold E
HE
Kim
D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009336:Necrosis; D009959:Oropharyngeal Neoplasms / Q000601:surgery / Q000628:therapy; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal; D012189:Retrospective Studies