[Genetic study of predisposition to community-acquired pneumonia].
The study included 243 patients with acute community-acquired pneumonia and 173 healthy subjects. The following candidate loci were used to investigate genetic variability: 3 sites of CYP1A1, GSTM1, GSTT1, GSTP1, ACE gene of the rennin-angiotensin system, chemokine receptor gene CCR5. Enhanced predisposition to pneumonia was shown to be characteristic of homozygotes in deletion at the ACE locus (OR = 1.8; p = 0.013), carriers of normal alleles of the GSTM1 locus (OR = 1.7; p = 0.010), and homozygotes in allele 606T of the CYP1A1 gene (OR = 1.6; p = 0.020).
V V
VV
Moroz
T V
TV
Smelaia
L E
LE
Salnikova
A M
AM
Golubev
A V
AV
Rubanovich
D000328:Adult; D017714:Community-Acquired Infections / Q000235:genetics* / Q000503:physiopathology; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011014:Pneumonia / Q000235:genetics* / Q000503:physiopathology; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D019713:Receptors, CCR5 / Q000235:genetics; D012720:Severity of Illness Index
D019713:Receptors, CCR5; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D007703:Peptidyl-Dipeptidase A