[Clinical characteristics and perinatal outcomes of non-overweight/obese pregnant women with polycystic ovary syndrome].
OBJECTIVE
To determine clinical characteristics and perinatal outcomes of non-overweight/obese (pre-pregnancy body mass index BMI < 24 kg/m(2)) pregnant women with polycystic ovary syndrome (PCOS).


METHODS
The screening of PCOS was performed when they were at first prenatal visit in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from May, 2008 to July, 2010.61 PCOS women of pregnancy women with BMI < 24 kg/m(2) were considered as the study subjects, and 122 pregnant women without PCOS matched by age and pre-pregnancy body mass index (BMI) were selected as the control ones. Patients with history of pre-pregnancy diabetes, hypertension, cardiovascular disease, renal diseases and multiple pregnancies were excluded from the study. We followed pregnancy outcomes of two groups until delivery.


RESULTS
Significantly higher total cholesterol, triglycerides concentrations and low-density lipoprotein cholesterol concentrations were found in the PCOS group than in the controls. PCOS women with BMI < 24 kg/m(2) had significantly higher rates of GDM (27.9% (17/61)) and pre-eclampsia (13.1% (8/61)) compared with the controls (15.6% (19/122), 1.6% (2/122)), P < 0.05, < 0.01, respectively. No statistical significance was found in prevalence of pregnancy-induced hypertension, polyhydramnios, oligohydramnios, macrosomia, premature rupture of membranes, placental abruption, macrosomia, fetal death and neonatal congenital abnormality between the two groups (all P > 0.05).


CONCLUSIONS
It is at increased risk of GDM and pre-eclampsia in non-overweight/obese PCOS women, this risk seemed to be due to PCOS itself rather than obesity.
Department of Obstetrics, Capital Medical University, Beijing, China.
Guang-hui
GH
Li
Ling
L
Fan
Li
L
Zhang
Xiao-wei
XW
Liu
Cheng-juan
CJ
Sun
Wei-yuan
WY
Zhang
Xing-hua
XH
Huang
D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009765:Obesity; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second