High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome.
OBJECTIVE
Polycystic ovary syndrome (PCOS) is characterized by insulin resistance. Chronic low-grade inflammation has been anticipated to play role in the pathogenesis of both insulin resistance and atherosclerosis. Pentraxin 3 (PTX3) is an inflammatory mediator synthesized in a variety of cells and tissues including heart, vascular endothelial cells, macrophages and adipocytes. In the present study, serum PTX3 level and its relationship with insulin resistance were investigated in patients with PCOS.


METHODS
Forty patients with PCOS and 40 age- and body mass index (BMI)-matched healthy controls were enrolled in the study. PTX3 and high-sensitivity C-reactive protein (hs-CRP) levels were determined by enzyme immunoassay (EIA). Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) formula.


RESULTS
Plasma levels of PTX3, hs-CRP and HOMA-IR scores were all significantly higher (p = 0.021, p = 0.002 and p = 0.0001, respectively) in women with PCOS compared with healthy controls. Blood PTX3 level correlated positively with hs-CRP, BMI, waist-to-hip ratio (WHR), HOMA-IR and negatively with high-density lipoprotein cholesterol level (p < 0.05, for all). After adjustment for age and BMI, PTX3, total testosterone levels and BMI remained as independent predictors of HOMA-IR scores (p < 0.05, for all).


CONCLUSIONS
PTX3 level is increased in patients with PCOS in concordance with insulin resistance.
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik, Ankara, Turkey. draydoganaydogdu@gmail.com
Aydogan
A
Aydogdu
Ilker
I
Tasci
Serkan
S
Tapan
Yalcin
Y
Basaran
Umit
U
Aydogan
Coskun
C
Meric
Alper
A
Sonmez
Sebnem
S
Aydogdu
Halil
H
Akbulut
Abdullah
A
Taslipinar
Gokhan
G
Uckaya
Omer
O
Azal
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D049629:Waist-Hip Ratio; D000099153:Pentraxins
D001786:Blood Glucose; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D007328:Insulin; D000683:Serum Amyloid P-Component; D000099153:Pentraxins