Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.
We present the case of a patient with a double transformation during the evolution of chronic hematopoietic malignancy - JAK2 positive chronic myeloproliferative neoplasm; the first transformation had occurred previous to the presentation in our Department, but the second transformation was observed in evolution and it was into a rapidly evolving disease, followed by survival of less than one month. We underline the very poor prognosis -- overall survival of 2.5 years from initial presentation -- a much reduced survival for a chronic myeloproliferative neoplasm, probably due also to multiple associated pathology. Also, the other interesting element of the case is related to the dysfunctional platelets -- hemorrhagic complication at increased platelet count, respectively thrombosis at platelet count under 20000/mmc.
Hematology Department, Emergency University Hospital Bucharest, Romania.
Diana
D
Cişleanu
Minodora
M
Onisâi
Ana-Maria
AM
Vlădăreanu
Mihaela
M
Găman
Ana-Maria
AM
Neagul
H
H
Bumbea
Anamaria
A
Iova
Cristina
C
Baluţa
Oana
O
Cazaceanu
Mădălina
M
Begu
Anca
A
Ilea
D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D017809:Fatal Outcome; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D008297:Male; D009154:Mutation; D010976:Platelet Count; D011087:Polycythemia Vera / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D055728:Primary Myelofibrosis / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D011379:Prognosis; D011655:Pulmonary Embolism / Q000175:diagnosis; D012307:Risk Factors; D013163:Splenomegaly; D013922:Thrombocytosis / Q000175:diagnosis; D054556:Venous Thromboembolism / Q000175:diagnosis
D000970:Antineoplastic Agents; D015415:Biomarkers; C507924:JAK2 protein, human; D053614:Janus Kinase 2