Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis.
The recent studies indicated that the epithelial cell adhesion molecule E-cadherin is a well-recognized molecule that is important in cell adhesion. To further investigate the molecular basis of this notion, we used small-interfering RNA to inhibit E-cadherin function and found that loss of E-cadherin promoted Colorectal cancer cell growth, invasion and drug resistance through induction of β-catenin nuclear translocation and epithelial-to-mesenchymal transition. Further analysis of E-cadherin expression with clinicopathologic parameters showed that E-cadherin expression decreased in Colorectal cancer patients who developed liver metastasis (P = 0.043). These findings indicate that E-cadherin loss in tumors contributes to progression and metastatic dissemination. Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer.
Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Xiaobing
X
Chen
Yongsheng
Y
Wang
Hongping
H
Xia
Qiwu
Q
Wang
Xiaochun
X
Jiang
Zihong
Z
Lin
Yuedong
Y
Ma
Yang
Y
Yang
Minghua
M
Hu
D021581:Active Transport, Cell Nucleus; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D005472:Fluorouracil / Q000494:pharmacology; D055785:Gene Knockdown Techniques; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008727:Methotrexate / Q000494:pharmacology; D009361:Neoplasm Invasiveness; D014158:Transcription, Genetic; D051176:beta Catenin / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D015820:Cadherins; D051176:beta Catenin; D005472:Fluorouracil; D008727:Methotrexate