Changes in refraction, ocular aberrations, and corneal structure after suspending rigid gas-permeable contact lens wear in keratoconus.
OBJECTIVE
This study reports on changes in visual acuity, ocular higher-order aberrations, and refraction after suspending rigid gas-permeable lens wear for 1 week in 15 patients with moderate to severe keratoconus. Alterations in the anterior surface, central corneal powers and axes, and central corneal thickness were also explored.


METHODS
Scheimpflug photography and Hartmann-Shack aberrometry were performed at 2 visits, 7 days apart, after the patients had removed their habitual contact lenses. Subjective refraction and both high- and low-contrast logarithm of the minimum angle of resolution visual acuities were also recorded at both visits.


RESULTS
Reductions in both high-contrast visual acuity (P = 0.001) and low-contrast visual acuity (P = 0.002), along with an increase in third-order root mean square aberrations (P = 0.008), occurred after rigid gas-permeable lens wear was suspended in these patients with keratoconus. However, no significant changes in subjective refraction were found over the 1-week period (P ≥ 0.10). Significant correlations were observed between third-order coma root mean square aberrations and the measured high-contrast (r(p) ≥ 0.59; P ≤ 0.02) and low-contrast visual acuities (r(P) ≥ 0.61; P ≤ 0.015). In addition to increases in the anterior surface central corneal powers (P ≤ 0.02), a reduction in central corneal thickness also was found between the 2 visits (P = 0.00016).


CONCLUSIONS
Changes in the optical and structural parameters of the keratoconic cornea occur after suspending rigid gas-permeable contact lens wear. This information may be of interest to practitioners concerned with prescribing aberration-controlling soft contact lenses for such patients.
Faculty of Life Sciences, University of Manchester, England, United Kingdom.
Amit
A
Jinabhai
Clare
C
O'Donnell
Hema
H
Radhakrishnan
D057128:Aberrometry; D000328:Adult; D003261:Contact Lenses; D003315:Cornea / Q000473:pathology*; D057108:Corneal Wavefront Aberration / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010781:Photography; D012029:Refraction, Ocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D028761:Withholding Treatment