[Efficacy of ivabradine in patients with stable angina and comorbid chronic obstructive pulmonary disease].
We investigated impact of ivabradine on exercise capacity and quality of life in patients with stable angina and comorbid chronic obstructive pulmonary disease during treatment with -blockers. Ivabradine with -blockers reduced heart rate, increased exercise capacity and improved angina more effective than -blockers only. Quality of life associated with angina  increased in patients with stage I and II chronic obstructive pulmonary disease. Addition of  ivabradine to -blockers for 2 month did not produce adverse respiratory effects.
A A
AA
Khamaeva
F I
FI
Belialov
L V
LV
Kerzina
O V
OV
Berezovskaia
E D
ED
Parshukova
G Iu
GIu
Zakharova
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D060050:Angina, Stable / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects; D001552:Benzazepines / Q000008:administration & dosage / Q000009:adverse effects; D015897:Comorbidity; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000037:antagonists & inhibitors; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D017079:Exercise Tolerance / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D000077550:Ivabradine; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000453:epidemiology; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001552:Benzazepines; D054815:Cyclic Nucleotide-Gated Cation Channels; D000077550:Ivabradine