LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.
LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-κB by LUBAC and the diseases associated with this process are the focus of this review.
Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan.
Fuminori
F
Tokunaga
Kazuhiro
K
Iwai
D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D016328:NF-kappa B / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*; D054875:Ubiquitination
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D044767:Ubiquitin-Protein Ligases; C554944:Sipl1 protein, mouse; C492590:Rnf31 protein, mouse; C000607389:Rbck1 protein, mouse