Direct use of esters in the Mukaiyama aldol reaction: a powerful and convenient alternative to aldehydes.
An indium triiodide catalyst promoted the direct transformation from esters to β-hydroxycarbonyl compounds using hydrosilanes and silyl enolates by a one-stage process. Various esters were applicable, and the high chemoselectivity of this system brings compatibility to many functional groups: alkenyl, alkynyl, chloro, and hydroxy.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yoshihiro
Y
Inamoto
Yoshihiro
Y
Nishimoto
Makoto
M
Yasuda
Akio
A
Baba
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure
D000447:Aldehydes; D004952:Esters; C116609:3-hydroxybutanal