Combination of familial Barlow's disease with bilateral axillary artery aneurysms in two brothers.
We encountered two brothers with a combination of Barlow's disease and bilateral axillary artery aneurysms who were operated on during their third decade of life. A symmetrical form of true bilateral axillary artery aneurysms is uncommon. Recurrent mitral regurgitation was presented in the older brother with an endocardial defect in the left atrium, suggesting connective tissue fragility. A hereditary connective tissue disorder was strongly suspected because of the similar presentation and an unusual cluster of pathologies in siblings. Careful follow-up is required to detect recurrence of mitral regurgitation or aneurysm formation in other vessels.
Division of Cardiovascular Surgery, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan. kasa7777@gmail.com
Hirofumi
H
Kasahara
Mikihiko
M
Kudo
Ryohei
R
Yozu
Susumu
S
Hosoda
Akira
A
Shiikawa
D000328:Adult; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D001366:Axillary Artery / Q000000981:diagnostic imaging / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D003240:Connective Tissue Diseases / Q000150:complications / Q000235:genetics*; D040181:Genetic Diseases, X-Linked / Q000235:genetics* / Q000601:surgery; D020022:Genetic Predisposition to Disease; D019918:Heart Valve Prosthesis Implantation; D040941:Heredity; D006801:Humans; D008297:Male; D058386:Mitral Valve Annuloplasty; D008945:Mitral Valve Prolapse / Q000235:genetics* / Q000601:surgery; D010641:Phenotype; D011859:Radiography; D012008:Recurrence; D035781:Siblings; D016896:Treatment Outcome