Gene expression of adipose tissue, endothelial cells and platelets in             subjects with metabolic syndrome (Review).
Metabolic syndrome is a combination of medical disorders including hypertension,             dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference,             and is associated with a higher risk of cardiovascular disease. An increase in             adipose tissue mass is associated with the augmented secretion of certain adipokines,             such as interleukin-6, tumor necrosis factor-α and resistin, which cause endothelial             dysfunction (an increase in vasoconstrictor molecules and in the expression of             adhesion molecules as well as a decrease of vasodilator molecules, amongst other             features) and hemostasis alterations that also favor a prothrombotic state (increased             fibrinogen and plasminogen activator inhibitor-1 concentrations and platelet activation/aggregation).             This interaction between adipose tissue, endothelial cells and platelets is associated             with an increase or decrease in the expression of several transcription factors             (peroxisome proliferator-activated receptors, CCAAT-enhancer-binding proteins,             carbohydrate responsive element-binding proteins and sterol regulatory element-binding             proteins) that play a crucial role in the regulation of distinct metabolic pathways             related to the metabolic syndrome. In the present review, we present the primary             changes in adipose tissue, endothelial cells and platelets in subjects with metabolic             syndrome and their possible target sites at the gene expression level.
Department of Clinical Biochemistry and Immunohematology, Faculty                     of Health Sciences, Universidad de Talca, Talca, Chile.
Pablo M
PM
Pérez
Rodrigo
R
Moore-Carrasco
Daniel R
DR
González
Eduardo Q
EQ
Fuentes
Iván G
IG
Palomo
D000273:Adipose Tissue / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors