Natural and synthetic α-methylenelactones and α-methylenelactams with anticancer potential.
α-Methylene-γ- and δ-lactones, as well as α-methylene-γ- and δ-lactams, are plant-derived compounds often used in traditional medicine for the treatment of inflammatory diseases. In recent years, the anticancer properties of these compounds and the molecular mechanisms of their action have been studied extensively. In the search for modern anticancer drugs, various synthetic analogs of α-methylene-γ- and δ-lactones and lactams have been synthesized and tested for their cytotoxic activity. In this review, we give a brief description of the occurrence and biological activity of such compounds isolated from plants and their diverse synthetic analogs.
Department of Biomolecular Chemistry, Medical University of Lodz, Poland. anna.janecka@umed.lodz.pl
Anna
A
Janecka
Anna
A
Wyrębska
Katarzyna
K
Gach
Jakub
J
Fichna
Tomasz
T
Janecki
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D055808:Drug Discovery; D006801:Humans; D007769:Lactams / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D023041:Xenograft Model Antitumor Assays
D000972:Antineoplastic Agents, Phytogenic; D007769:Lactams; D007783:Lactones; C416683:methylene-lactone