New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger.
Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
Fisicoquimica, Facultad de Farmacia y Bioquimica, Junin 956, 1113 Buenos Aires, Argentina.
Gabriela
G
Malanga
María Belen
MB
Aguiar
Hugo D
HD
Martinez
Susana
S
Puntarulo
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D003642:Deanol / Q000008:administration & dosage / Q000494:pharmacology*; D003683:Dehydroascorbic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D003642:Deanol; D017665:Hydroxyl Radical; C000820:semidehydroascorbic acid; D003683:Dehydroascorbic Acid