Orbital embryonal rhabdomyosarcoma with metastasis in a young dog.
A 2-year-old male Welsh corgi dog was brought to an animal hospital because of left upper eyelid enlargement with lachrymal gland protrusion. The lachrymal and orbital cavity mass was removed surgically. Microscopically, the orbital mass consisted of a mixture of large rhabdomyoblastic and small round tumour cells. Immunohistochemically, the rhabdomyoblastic cells expressed desmin and myoglobin and the small round cells expressed desmin, myogenin and MyoD1. A diagnosis of embryonal rhabdomyosarcoma (ERS) was made. One month later, multiple masses throughout the body were identified, in particular around the cervical region. One of these lesions was sampled and diagnosed as metastatic ERS. The dog died 84 days after the time of first admission.
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Y
Y
Kato
H
H
Notake
J
J
Kimura
M
M
Murakami
A
A
Hirata
H
H
Sakai
T
T
Yanai
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D003893:Desmin / Q000378:metabolism; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D017570:MyoD Protein / Q000378:metabolism; D018008:Myogenin / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D018233:Rhabdomyosarcoma, Embryonal / Q000378:metabolism / Q000556:secondary / Q000601:surgery / Q000662:veterinary*
D014408:Biomarkers, Tumor; D003893:Desmin; D017570:MyoD Protein; D018008:Myogenin; D009211:Myoglobin