[Endocrinology].
Recent discoveries in molecular biology offer new perspectives in the treatment of endocrine tumors. There is currently no medical therapy for Cushing's disease that targets the pituitary adenoma. Pasireotide, a new somatostatin analog, demonstrates a strong affinity for somatostatin receptors expressed by corticotroph adenomas. Some recent clinical trials showed a decrease of urinary free cortisol with pasireotide. This new treatment could be useful in case of pituitary surgery failure. Thyroid tumorigenesis involves kinase signaling cascade. Tyrosine-kinase inhibitors have now been tested in the treatment of progressive differentiated iodine refractory thyroid carcinomas or medullary carcinomas and showed modestly encouraging results.
Service de médecine interne générale, HUG, 1211 Genève 14. adriana.missana@hcuge.ch
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D049913:ACTH-Secreting Pituitary Adenoma / Q000188:drug therapy; D000236:Adenoma / Q000188:drug therapy; D001557:Benzenesulfonates / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D018276:Carcinoma, Medullary / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004701:Endocrine Gland Neoplasms / Q000188:drug therapy; D004704:Endocrinology / Q000639:trends; D006801:Humans; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047748:Pituitary ACTH Hypersecretion / Q000188:drug therapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011725:Pyridines / Q000627:therapeutic use; D017481:Receptors, Somatostatin / Q000187:drug effects; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077157:Sorafenib; D013964:Thyroid Neoplasms / Q000188:drug therapy; D016896:Treatment Outcome
D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D017481:Receptors, Somatostatin; D009536:Niacinamide; D013004:Somatostatin; C517782:pasireotide; D000077157:Sorafenib; D011505:Protein-Tyrosine Kinases