Recent advance in the pharmacology of dihydropyrimidinone.
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.
Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
J-P
JP
Wan
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Pan
D018674:Adrenergic Antagonists / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*; D011979:Receptors, Pituitary Hormone / Q000037:antagonists & inhibitors
D018674:Adrenergic Antagonists; D002121:Calcium Channel Blockers; D004791:Enzyme Inhibitors; D011744:Pyrimidinones; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor