[Implication of functional platelet activity in pathogenesis of Q-fever].
OBJECTIVE
To ascertain the role of platelets in pathogenesis of clinical symptoms in patients with Q-fever.


METHODS
We studied hemostasis with estimation of functional platelet activity in 49 patients with Q-fever.


RESULTS
Hemorrhagic syndrome (HS) occurred in 34.4% patients with Q-fever (QF) during seasonal rise of morbidity. HS manifested with petechiae (12%), hematomas (32%), nasal bleeding (17%), stomatorrhagia (9%), melena (12%). Characteristics and duration of such symptoms as weakness (100%), myalgia (72%), arthralgia (52.9%) suggested hemocoagulatory disorders as a cause of the symptoms appearance. At the height of the disease thrombocytopenia was accompanied with inhibition of platelet aggregation activity, but regression of the clinical symptoms was associated with an increase in platelet count and platelet hyperaggregation. Fibrinogen content was elevated during hospitalization in 50% patients.


CONCLUSIONS
Clinical manifestations of HS are typical for Q-fever prevalent in the Astrakhan Region. Hemostatic disorders because of altered functional activity of platelets were registered in all the cases and evidence for pathogenetic unbalance of homeostasis in Q-fever patients.
E N
EN
Lazareva
V V
VV
Maleev
Kh M
KhM
Galimzianov
A V
AV
Burkin
M M
MM
Khok
A M
AM
Poliakova
O S
OS
Astrina
M A
MA
Babaeva
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D006760:Hospitalization; D006801:Humans; D010974:Platelet Aggregation; D010976:Platelet Count; D011778:Q Fever / Q000503:physiopathology*; D012426:Russia; D013921:Thrombocytopenia / Q000209:etiology
D005340:Fibrinogen