Abnormal brain structure implicated in stimulant drug addiction.
Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual's health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK. ke220@cam.ac.uk
Karen D
KD
Ersche
P Simon
PS
Jones
Guy B
GB
Williams
Abigail J
AJ
Turton
Trevor W
TW
Robbins
Edward T
ET
Bullmore
D000293:Adolescent; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D016880:Anisotropy; D016739:Behavior, Addictive / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D001921:Brain / Q000002:abnormalities* / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D001931:Brain Mapping; D019970:Cocaine-Related Disorders / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D003342:Corpus Striatum / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D004198:Disease Susceptibility; D058068:Endophenotypes; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D011930:Reaction Time; D035781:Siblings; D055815:Young Adult