A new practical approach towards the synthesis of unsymmetric and symmetric 1,10-phenanthroline derivatives at room temperature.
An efficient method towards synthesis of 1,10-phenanthrolines is described. Through Lewis acid-catalyzed annulation reaction between 3-ethoxycyclobutanones and 8-aminoquinolines, a variety of unsymmetric and symmetric 1,10-phenanthroline derivatives were readily prepared with high regioselectivity at room temperature.
Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Yongfeng
Y
Cheng
Xuesong
X
Han
Huangche
H
Ouyang
Yu
Y
Rao
D000634:Aminoquinolines / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D000634:Aminoquinolines; D010618:Phenanthrolines; C080436:8-aminoquinoline; C025205:1,10-phenanthroline