Synthesis of benzoylacetonitriles from Pd-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile.
Palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile to produce benzoylacetonitrile derivatives through a one-pot, three-component reaction is described. This preparation method provides good yields of the carbonylated products without any additional ligands. It has a broad substrate scope with a high tolerance for a variety of functional groups.
Department of Chemistry, Chonnam National University, Gwangju, 500-757, Republic of Korea.
Ahbyeol
A
Park
Sunwoo
S
Lee
D000097:Acetonitriles / Q000138:chemical synthesis / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D000097:Acetonitriles; D007454:Iodides; D008024:Ligands; D012997:Solvents; D014297:Trimethylsilyl Compounds; D010165:Palladium; D001554:Benzene; C032159:acetonitrile