[Haemophagocytic syndrome in pregnancy: a case report].
Haemophagocytic syndrome (HPS) results from an inappropriate stimulation of macrophages in bone marrow and lymphoid organs, leading to haemophagocytosis and hypercytokinemia. HPS may be primitive, essentially in pediatric population, or secondary to malignancy, infection or autoimmune disease. This disease is rare and prognosis is poor. A small number of cases during pregnancy have been described in literature. We report one HPS case in a pregnant patient at 21 week's gestation with systemic lupus erythematosus. We discuss diagnostic difficulties, obstetrical complications and therapeutic options.
Service de gynécologie obstétrique, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, université Lille 2, 59037 Lille, France. montaigne.k@wanadoo.fr
K
K
Hannebicque-Montaigne
A
A
Le Roc'h
D
D
Launay
C
C
Coulon
P
P
Deruelle
S
S
Langlois
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000628:therapy*; D010587:Phagocytosis; D006473:Postpartum Hemorrhage / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000628:therapy*; D011655:Pulmonary Embolism / Q000209:etiology / Q000628:therapy; D013921:Thrombocytopenia / Q000150:complications
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D016207:Cytokines