[To observe postoperative analgesia and preemptive analgesia of Tramadol hydrochloride sustained release tablets for nasal endoscopic operation].
OBJECTIVE
To observe postoperative analgesia and preemptive analgesia of Tramadol hydrochloride sustained release tablets for nasal endoscopic operation.


METHODS
A total of 188 patients undergoing nasal endoscopic operation were randomized into the experimental group and control group, with 94 patients in each group. Each patient in experimental group was gaved on Tramadol hydrochloride sustained release tablets at 12h, 24h, 48h, postoperation and before the cleaning up procession respectively, the control group was not administered. VAS scores were observed at 12, 24, and 48 hours after operation. The discomfort reaction during postoperation and cleaning up procession such as insomnia, impatien, nervous, frightening, syncope and shock were also observed and recorded.


RESULTS
Visuala analogue scale scores of the experimental groups after 12, 24 hours and 48h were significantly lower than the control group. The discomfort reaction appear more frequently in control group.


CONCLUSIONS
Tramadol hydrochloride sustained release tablets effectively relieves postoperative pain of nasal endoscopic operation. It can also decrease the discomfort reaction during postoperation and cleaning up procession and facilitate recovering of patients.
Department of Otolaryngology-Head and Neck Surgery, Central Hospital of Ezhou, China. hhxxnn@gmail.com
Xiaolin
X
Huang
Yu
Y
Xu
Yan
Y
Mei
Xinyu
X
Wu
Wenshang
W
Yu
Benyuan
B
Pi
Lin
L
Zhou
Wei
W
Li
Chen
C
Li
D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059747:Nasal Surgical Procedures / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011184:Postoperative Period; D014147:Tramadol / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D014147:Tramadol