Swelling behaviour and controlled drug release from cross-linked κ-carrageenan/NaCMC hydrogel by diffusion mechanism.
We studied a model system of controlled drug release using beta-carotene and κ-carrageenan/NaCMC hydrogel as a drug and a device, respectively. Different concentrations of genipin were added to crosslink the beta-carotene loaded beads by using the dripping method. Results have shown that the cross-linked beads possess lower swelling ability in all pH conditions (pH 1.2 and 7.4), and swelling ratio decreases with increasing genipin concentration. Microstructure study shows that cross-linking has enhanced the stability and structure of the beads network. Determination of diffusion coefficient for the release of encapsulated beta-carotene indicates less diffusivity when beads are cross-linked. Swelling models using adaptive neuro fuzzy show that using genipin as a cross-linker in the kC/NaCMC hydrogels affects the transport mechanism. The model shows very good agreement with the experimental data that indicates that applying ANFIS modelling is an accurate, rapid and simple way to model in such a case for controlled release applications.
Faculty of Chemical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia.
Hadi
H
Hezaveh
Ida Idayu
II
Muhamad
Iman
I
Noshadi
Lim
L
Shu Fen
Norzita
N
Ngadi
D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002351:Carrageenan / Q000737:chemistry; D003432:Cross-Linking Reagents; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D017143:Fuzzy Logic; D020100:Hydrogels; D039823:Iridoids; D008855:Microscopy, Electron, Scanning; D016571:Neural Networks, Computer; D019207:beta Carotene / Q000008:administration & dosage
D003432:Cross-Linking Reagents; D004337:Drug Carriers; D020100:Hydrogels; D039823:Iridoids; D019207:beta Carotene; D002351:Carrageenan; C007834:genipin; D002266:Carboxymethylcellulose Sodium