Ropren(®) is a polyprenol preparation from coniferous plants that ameliorates cognitive deficiency in a rat model of beta-amyloid peptide-(25-35)-induced amnesia.
This study assesses the efficacy of a fixed dose of Ropren(®) (a plant preparation isolated from the neutral fraction of an extract of spruce needles) on cognitive impairment in rats with β-amyloid peptide-(25-35)-induced amnesia. Ropren(®) was administered at a dose of 8.6mg/kg for 28 days, per os, to rats with β-amyloid peptide-(25-35)-induced amnesia. Cognitive performance was assessed using the passive avoidance paradigm and the Morris water maze and behavior was assessed using the open field test. After four weeks, Ropren(®) treatment significantly improved non-spatial and spatial learning in rats with β-amyloid peptide-(25-35)-induced amnesia. The results of the present study suggest that Ropren(®), a novel plant preparation, ameliorates cognitive deficiencies in an animal model relevant to Alzheimer's disease.
Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, Nab. Makarova 6, St. Petersburg 199034, Russia. julia.fedotova@mail.ru
Julia
J
Fedotova
Vagif
V
Soultanov
Tamara
T
Nikitina
Victor
V
Roschin
Natalia
N
Ordayn
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003072:Cognition Disorders / Q000517:prevention & control*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D023421:Models, Animal; D018515:Plant Leaves / Q000737:chemistry; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D059808:Polyphenols / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D064028:Tracheophyta / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D028321:Plant Preparations; D059808:Polyphenols; C439320:amyloid beta-protein (25-36)