Venovenous hemodiafiltration and hypothermia for treatment of cerebral edema associated with hyperammonemia.
We report a 50 hour old newborn with inborn urea cycle disorder and hyperammonia of 2320 umol/L. The pharmacological treatment of the first metabolic crisis was combined with venovenous hemodiafiltration and therapeutic hypothermia to rescue the patient from a life-threatening cerebral edema.
General Hospital of Vienna, Department of Pediatrics and Adolescent Medicine, Division of General Pediatrics and Neonatology, Vienna, Austria. regina.vargha@meduniwien.ac.at
R
R
Vargha
D
D
Möslinger
O
O
Wagner
J
J
Golej
D001929:Brain Edema / Q000209:etiology / Q000628:therapy*; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D022124:Hyperammonemia / Q000150:complications / Q000628:therapy*; D007036:Hypothermia, Induced / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D056806:Urea Cycle Disorders, Inborn / Q000150:complications / Q000628:therapy*