Outcome of patients with regadenoson-induced ST-segment depression but normal perfusion on single-photon emission computed tomography.
The prognostic significance of ischemic electrocardiographic (ECG) changes during Regadenoson vasodilator stress in patients with normal single-photon emission computed tomographic myocardial perfusion imaging (SPECT-MPI) is not well described. Of 2473 patients who underwent Regadenoson vasodilator stress testing, 43 (77% women, mean age 72 ± 10 years) patients were included in the study. During a mean follow-up of 14 ± 7 months, cardiac death occurred in 1 patient; 5 patients underwent coronary revascularization and none had myocardial infarction. The annual rate of cardiac death and coronary revascularization was 1.9% and 9.9%, respectively. The finding of ischemic ECG changes with normal SPECT-MPI during regadenoson vasodilator stress testing is uncommon, occurs primarily in older women, and is associated with moderately higher subsequent cardiac event rate.
Department of Cardiovascular Imaging, Cardiac MR/PET/CT program, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Boston, MA 02114, USA
Shanmugam
S
Uthamalingam
Gagandeep S
GS
Gurm
Imad
I
Ahmado
Manavjot S
MS
Sidhu
James
J
Flynn
D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000175:diagnosis*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011379:Prognosis; D011687:Purines / Q000008:administration & dosage / Q000009:adverse effects; D011720:Pyrazoles / Q000008:administration & dosage / Q000009:adverse effects; D018570:Risk Assessment; D015996:Survival Rate; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects
D011687:Purines; D011720:Pyrazoles; D014665:Vasodilator Agents; C430916:regadenoson