Antiviral properties of polymeric aziridine- and biguanide-modified core-shell magnetic nanoparticles.
Polycationic superparamagnetic nanoparticles (∼150-250 nm) were evaluated as virucidal agents. The particles possess a core-shell structure, with cores consisting of magnetite clusters and shells of functional silica covalently bound to poly(hexamethylene biguanide) (PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine moieties. Aziridine was conjugated to the PEI shell through cationic ring-opening polymerization. The nanometric core-shell particles functionalized with biguanide or aziridine moieties are able to bind and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic septicaemia virus (VHSV). The virus-particle complexes can be efficiently removed from the aqueous milieu by simple magnetocollection.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Lev
L
Bromberg
Daniel J
DJ
Bromberg
T Alan
TA
Hatton
Isabel
I
Bandín
Angel
A
Concheiro
Carmen
C
Alvarez-Lorenzo
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001388:Aziridines / Q000737:chemistry; D001645:Biguanides / Q000737:chemistry; D018061:Infectious pancreatic necrosis virus / Q000187:drug effects; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D000998:Antiviral Agents; D001388:Aziridines; D001645:Biguanides; D011108:Polymers; C033132:aziridine; D011094:Polyethyleneimine