Serum brain natriuretic peptide and C-reactive protein levels in adolescent with polycystic ovary syndrome.
OBJECTIVE
Our primary aim was to investigate whether N-terminal pro-brain natriuretic peptide (NT-proBNP) increases in adolescent with polycystic ovary syndrome (PCOS) compared with healthy controls and secondary aim was to determine whether metabolic and hormonal differences exist between groups.


METHODS
In this cross-sectional study, 25 adolescent patients with PCOS and 25 normal ovulatory control not suffering from PCOS were involved in the study. Fasting serum NT-proBNP, C-reactive protein (CRP), homocystein, insulin levels and biochemical and hormonal parameters were measured.


RESULTS
Serum NT-proBNP was not significantly different in PCOS subjects (0.62 ± 0.80 vs 1.12 ± 1.51 ng/mL, p = 0.154). The mean serum fasting insulin levels (22.64 ± 10.51 vs 13.32 ± 3.97 mIU/mL, p = 0.001) and Homeostasis Model Assessment Insulin-Resistance Index (HOMA-IR) levels (5.16 ± 1.81 vs 2.97 ± 0.89, p = 0.001) were significantly high in the study group. The median serum CRP levels were not significantly different between groups (1 [1-12] vs 1 [1-19] g/dL, p = 0.286).


CONCLUSIONS
The present study demonstrated that the levels of BNP, CRP and homocystein were not different in PCOS subjects. Serum insulin levels and HOMA-IR were significantly higher in PCOS subjects. Possible serum markers for PCOS-related metabolic abnormalities and cardiovascular events, may not present in the adolescent years.
Gynecology and Obstetrics Department, Dr. Zekai Tahir Burak Women Health Education and Research Hospital, Ankara, Turkey. deveer3@hotmail.com
Rüya
R
Deveer
Yaprak
Y
Engin-Üstün
Sema
S
Uysal
Filiz Akın
FA
Su
Seval
S
Sarıaslan
Cavidan
C
Gülerman
Leyla
L
Mollamahmutoğlu
D000152:Acne Vulgaris / Q000209:etiology; D000293:Adolescent; D041923:Adolescent Development; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D007333:Insulin Resistance; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009839:Oligomenorrhea / Q000209:etiology; D010053:Ovary / Q000000981:diagnostic imaging; D010446:Peptide Fragments / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D014421:Turkey; D014463:Ultrasonography; D055815:Young Adult
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein