Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors.
Medicinal Chemistry, iScience, CNSP iMed, AstraZeneca R&D Södertälje, Västra Mälarehamnen 9, 15185 Södertälje, Sweden.
Fernando
F
Sehgelmeble
Juliette
J
Janson
Colin
C
Ray
Susanne
S
Rosqvist
Susanne
S
Gustavsson
Linda I
LI
Nilsson
Alexander
A
Minidis
Jörg
J
Holenz
Didier
D
Rotticci
Johan
J
Lundkvist
Per I
PI
Arvidsson
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002478:Cells, Cultured; D005260:Female; D022781:Hepatocytes / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D007279:Injections, Subcutaneous; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases