Subcutaneous allergen-specific immunotherapy versus topical treatment in vernal keratoconjunctivitis.
OBJECTIVE
The study evaluated the treatment of cases with vernal keratoconjunctivitis by subcutaneous allergen-specific immunotherapy (SCIT) versus topical treatment according to clinical improvement and total serum immunoglobulin (Ig) E.


METHODS
Prospective randomized study.


METHODS
The study included 64 patients with bilateral vernal keratoconjunctivitis. Cases were divided into 2 groups: group 1, 32 patients who were subjected to topical treatment; and group 2, 32 patients who were subjected to intradermal skin reactions to different allergens. Prepared subcutaneous injections of different allergens were administered. Follow-up was performed to detect criteria of improvement according to clinical data and total serum IgE.


RESULTS
The study revealed that the treatment by SCIT was more effective in improving the clinical symptoms and reducing the serum IgE than topical treatment because there was a greater reduction in symptoms in group 1 of immunotherapy (72%) than in group 2 of medical treatment (59%) (P < 0.05). Also, there was a significant reduction in total serum IgE (P < 0.05) in group 1 (62%) compared to group 2 (42%). However, the intradermal test for each group of patients showed that 62% of the patients were sensitive to pollens, 19% to house dust, and 19% to more than one allergen.


CONCLUSIONS
Treatment of vernal keratoconjunctivitis by SCIT was more effective than topical treatment in improving the clinical symptoms and reducing the total serum IgE.
Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt. redaelmahdy2005@yahoo.com
Reda Abdel Rahman
RA
Mahdy
Waled M
WM
Nada
Ayman A
AA
Marei
D000287:Administration, Topical; D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage*; D002648:Child; D003233:Conjunctivitis, Allergic / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007271:Injections, Intradermal; D008297:Male; D011446:Prospective Studies; D012882:Skin Tests; D055815:Young Adult
D000485:Allergens; D007073:Immunoglobulin E