Recombinant human TSH increases uptake and effective half-life of radioiodine in thyroid hormone secreting metastases of follicular thyroid cancer.
Follicular thyroid cancer with thyroid hormone secreting metastases is an extremely rare condition, with only a few cases reported world-wide. We here present the case of a 64-year-old female patient affected by follicular thyroid cancer with extensive thyroid hormone secreting metastases leading to TSH-suppression. We have also summarized the relevant diagnostic and therapeutic approaches and describe, for the first time, the effects of rhTSH-application in this rare tumor entity. In this patient, we found that rhTSH increased ¹³¹I-uptake into the thyroid hormone secreting metastases and prolonged the effective half-life of ¹³¹I. These effects of rhTSH should be considered when fixed activities of ¹³¹I are prescribed.
University Hospital of Cologne, Department of Nuclear Medicine, Cologne, Germany. christina.schneider_@uk-koeln.de
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C
Schneider
M
M
Dietlein
W
W
Eschner
M
M
Schmidt
D
D
Kahraman
C
C
Kobe
D018263:Adenocarcinoma, Follicular; D003131:Combined Modality Therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013963:Thyroid Hormones / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D057073:Thyrotropin Alfa / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome; D015854:Up-Regulation / Q000187:drug effects
D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D057073:Thyrotropin Alfa