[Chronobiology of blood pressure and chronopharmacotherapy of arterial hypertension].
Arterial blood pressure is subject to a circadian rhythm that results in a fall                     of blood pressure during the night. In patients with diabetes, renal                     insufficiency, left-ventricular hypertrophy, sleep apnea, hypertension of                     pregnancy, and different forms of secondary hypertension a nocturnal fall of                     blood pressure is even abandoned or reverted. Diagnosis is made using 24-h blood                     pressure measurement, which is however used not frequently enough for a clinical                     assessment or adjustment of therapy. An adaption of the selection or the time of                     administration of antihypertensive drugs with respect to the circadian rhythm is                     beneficial to control blood pressure and reduce cardiovascular morbidity. This                     is particularly true for patients with an a non- or inverted dipping blood                     pressure pattern, in which the bedtime dosing may result in a normalization of                     blood pressure and restoration of a normal circadian rhythm. The present                     manuscript reviews the chronopharmacotherapy of arterial hypertension and grant                     practical recommendations for their translation into clinical practice.
Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen. roland.schmieder@uk-erlangen.de
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D000367:Age Factors; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D055870:Drug Chronotherapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*
D000959:Antihypertensive Agents