Relationship among plasma adipokines, insulin and androgens level as well as biochemical glycemic and lipidemic markers with incidence of PCOS in women with normal BMI.
Polycystic ovary syndrome (PCOS) is an endocrine disorder in women. Omentin-1 and vaspin are secretary adipokines that are produced by the visceral adipose tissue. These levels change in obese women with PCOS. The aim of this study is to investigate whether omentin and vaspin levels change in nonobese PCOS subjects. This study is a cross-sectional case control study in which 39 women with PCOS were picked out for this study. The inclusion criteria were based on the Rotterdam 2003 diagnostic criteria. The control group consisted of 39 women with normal pelvic sonographic reports having regular menstruation and showing no signs of infertility. The fasting plasma glucose (FPG), triglyceride (TG), Chol, and high-density lipoprotein cholesterol (HDL-C), insulin, testosterone, omentin and vaspin were measured by the enzymatic methods. The differences within these groups were calculated by the un-paired t-test and the Mann-Whitney test. The results from this study show a significant increase in the amount of insulin, testosterone, homeostasis model assessments for insulin resistance, TG and lower HDL in the patient group. No significant differences were seen in omentin, vaspin, FPG, Cho, low-density lipoprotein, very low-density lipoprotein cholesterol, blood urea nitrogen, Cr and homeostasis model assessments for B cell function levels between groups. Results show that PCOS is not a determinant of decreased omentin and vaspin plasma levels and those high androgen level and insulin resistances are warning signs of PCOS.
Department of Biochemistry, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IR Iran.
Samad
S
Akbarzadeh
Soghra
S
Ghasemi
Mohamadreza
M
Kalantarhormozi
Iraj
I
Nabipour
Fateme
F
Abbasi
Alnaz
A
Aminfar
Seyed Mojtaba
SM
Jaffari
Niloofar
N
Motamed
Ali
A
Movahed
Mostafa
M
Mirzaei
Ali Reza
AR
Rahbar
D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D042241:Early Diagnosis; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D006946:Hyperinsulinism / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology; D015994:Incidence; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007492:Iran / Q000453:epidemiology; D037102:Lectins / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D015843:Serpins / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
D054392:Adipokines; D000728:Androgens; D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D007328:Insulin; D037102:Lectins; C507339:SERPINA12 protein, human; D015843:Serpins; D014280:Triglycerides