Thrombopoietin and mean platelet volume in patients with ischemic stroke.
OBJECTIVE
The aim of this study was to evaluate mean platelet volume (MPV), thrombopoietin (TPO), and platelet levels in patients with ischemic stroke and compare this with healthy controls.


METHODS
We prospectively studied 50 patients with ischemic stroke and compared them with 37 control participants who have evaluated in internal medicine polyclinic and had no history of cerebrovascular events. All patients were within 24 hours after stroke; MPV and TPO were measured on admission.


RESULTS
Both TPO and MPV values were significantly higher in patients with stroke (P = .00; P = .001).


CONCLUSIONS
Increased TPO levels may increase both platelet count and platelet size, resulting in more hemostatic tendency, which may contribute to the progression of ischemic stroke.
Department of Hematology, Faculty of Medicine, Fatih University, Ankara, Turkey.
Özlem Sahin
ÖS
Balcik
Sule
S
Bilen
Ersin Kasim
EK
Ulusoy
Derya
D
Akdeniz
Sema
S
Uysal
Mustafa
M
Ikizek
Fikri
F
Ak
Ali
A
Kosar
D001792:Blood Platelets / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D020521:Stroke / Q000097:blood*; D013926:Thrombopoietin / Q000097:blood*; D013997:Time Factors
D013926:Thrombopoietin