Nephrogenic systemic fibrosis following acute kidney injury and exposure to gadolinium.
Nephrogenic systemic fibrosis (NSF) is a scleroderma-like systemic fibrosing condition of unknown etiology described in patients with renal insufficiency. Gadolinium exposure has been strongly associated with the development of NSF though the mechanism of such injury is not known. There are only few reported cases of NSF in the setting of acute renal failure and fewer reported cases where skin lesions developed after kidney function had returned to normal. We report a case of NSF in a young Hispanic woman with lupus nephritis but normal creatinine, who received gadolinium during a brief episode of prerenal acute kidney injury not requiring dialysis, secondary to sepsis.
Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA. archanabhaskaran@hotmail.com
Archana
A
Bhaskaran
Purna
P
Kashyap
Brent
B
Kelly
Princy
P
Ghera
D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D008181:Lupus Nephritis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000009:adverse effects* / Q000379:methods; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced* / Q000473:pathology* / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D005682:Gadolinium