Infection of cells by alphaviruses.
It is widely accepted that alphaviruses enter cells by a process involving endocytosis and low-pH-mediated virus membrane-cell membrane fusion. This model and the data supporting it have received extensive and numerous reviews. The major points presented in support of this model are summarized briefly herein. It is the primary objective of this review to present an alternative mechanism describing the penetration of cells by alphaviruses which does not involve endocytosis or exposure to acid environment. The data supporting this model are summarized in detail.
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA. dennis_brown@ncsu.edu
Dennis T
DT
Brown
Raquel
R
Hernandez
D000524:Alphavirus / Q000378:metabolism / Q000472:pathogenicity* / Q000648:ultrastructure; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure / Q000821:virology*; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry; D053586:Virus Internalization
D020409:Molecular Motor Proteins; D014764:Viral Proteins