[Pressure wave reflections and central blood pressure in treated hypertensive subjects].
OBJECTIVE
To investigate the differences in pressure wave reflections and central blood pressure between brachial BP classification and the effect of antihypertensive drugs.


METHODS
In 1371 chronically treated hypertensive subjects aged 33 - 87 years [679 males and 692 females, mean age (47.2 ± 11.5) years], radial arterial augmentation index (rAI) and central systolic blood pressure were measured using an automated tonometric method.


RESULTS
rAI gradually increased from the subgroup with the lower blood pressure to the higher blood pressure (P < 0.01), for each given brachial value, central systolic blood pressure was lower than the corresponding brachial pressure (P < 0.01). In multivariable linear regression models analysis revealed that the application of angiotensin converting enzyme inhibitor (β = -0.09, P < 0.05), AT1 receptor blockade (β = -0.07, P = 0.01), calcium channel blocker (β = -0.12, P < 0.01) and diuretic (β = 0.14, P = 0.04) were independent determinants of rAI. Central SBP significantly correlated to the application of ACEI (β = -0.07, P = 0.02), ARB (β = -0.08, P = 0.01) and CCB (β = -0.15, P < 0.05).


CONCLUSIONS
In chronically treated hypertensive individuals, tight blood pressure control would be effective in reducing the reflection wave and central BP. Antihypertensive treatment strategies with more beneficial effects on arterial properties are needed.
Second Department of Cardiology, Southern Building Clinic Division, People's Liberation Army General Hospital, Beijing 100853, China.
Wen-kai
WK
Xiao
Ping
P
Ye
Lei-ming
LM
Luo
De-jun
DJ
Liu
Hong-mei
HM
Wu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D001795:Blood Pressure Determination; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017534:Radial Artery / Q000503:physiopathology
D000959:Antihypertensive Agents