The effect of NitrAdine on the Candida levels of maxillary removable appliances.
OBJECTIVE
Candida colonization is a consequence of orthodontic treatment and can lead to oral candidosis as a complication of maxillary removable appliance treatment. During orthodontic treatment, it is important to minimize colonization to prevent active infection that could consequently interfere with treatment. Hygiene is the most important factor in managing colonization; in this study, the efficacy of NitrAdine to reduce Candida was tested.


METHODS
A randomized, double-blind, placebo-controlled trial was performed. Ninety-two patients 11 to 14 years of age were recruited at the Children's and the University Dental Clinics at Mater Dei Hospital, Tal-Qroqq, Msida, Malta. Forty-four patients used the product with NitrAdine, while 48 patients used a placebo. Sampling employing the imprint technique was performed before and after the product was used. Brilliance Candida agar was used for cultures and identification. Further identification was performed using Auxacolor 2 when required.


RESULTS
The control group had a statistically significant increase in Candida during treatment, while the experimental group had a nonstatistically significant decrease.


CONCLUSIONS
It was concluded that NitrAdine may reduce the Candida burden in maxillary removable appliances. Larger sample sizes are needed to achieve statistical significance.
Pathology Department, Mater Dei Hospital, Msida, Malta. stephendecelis@gov.mt
Stephen
S
Decelis
Simon
S
Camilleri
Ethel Vento
EV
Zahra
Erica
E
Scerri
Bart
B
De Wever
D000293:Adolescent; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000302:isolation & purification; D041022:Candida tropicalis / Q000187:drug effects / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000517:prevention & control*; D002648:Child; D015169:Colony Count, Microbial; D019551:Dental Disinfectants / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009055:Mouth / Q000382:microbiology; D009172:Mycology / Q000379:methods; D009968:Orthodontic Appliances, Removable / Q000382:microbiology*; D016877:Oxidants / Q000627:therapeutic use; D010919:Placebos; D012737:Sex Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation; D016896:Treatment Outcome
D019551:Dental Disinfectants; D016877:Oxidants; D010919:Placebos