The porous borders of the protein world.
Fold switching may play a role in the evolution of new protein folds and functions. He et al., in this issue of Structure, use protein design to illustrate that the same drastic change in a protein fold can occur via multiple different mutational pathways.
Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Matthew H J
MH
Cordes
Katie L
KL
Stewart
D019943:Amino Acid Substitution; D001426:Bacterial Proteins / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D017510:Protein Folding
D001426:Bacterial Proteins; C034284:IgG Fc-binding protein, Streptococcus; D010446:Peptide Fragments