Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis.
OBJECTIVE
Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children.


METHODS
Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate.


RESULTS
The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P<0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r=0.26; P=0.02), which was not apparent in OSA (r=0.14; P=0.09).


CONCLUSIONS
This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.
Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rana
R
Ezzeddini
Masoud
M
Darabi
Babollah
B
Ghasemi
Yalda
Y
Jabbari Moghaddam
Yalda
Y
Jabbari
Shahin
S
Abdollahi
Nadereh
N
Rashtchizadeh
Abasaad
A
Gharahdaghi
Maryam
M
Darabi
Masoud
M
Ansarin
Maghsood
M
Shaaker
Akbar
A
Samadi
Jamal
J
Karamravan
D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D054501:Group II Phospholipases A2 / Q000097:blood*; D006801:Humans; D008297:Male; D012008:Recurrence; D020181:Sleep Apnea, Obstructive / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D014068:Tonsillectomy; D014069:Tonsillitis / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
D015415:Biomarkers; D054501:Group II Phospholipases A2