Magnetic Fe3O4 nanoparticles coupled with a fluorescent Eu complex for dual imaging applications.
Magnetic 8 nm Fe(3)O(4) nanoparticles (NPs) were synthesized and modified with dopamine (DPA) and polyethylene glycol (PEG) diacid. The water soluble Fe(3)O(4)-DPA-PEG NPs were then conjugated with the fluorescent Eu(iii) complex of tris(dibenzoylmethane)-5-amino-1,10-phenanthroline (BMAP), giving an Fe(3)O(4)-DPA-PEG-BMAP-Eu NP conjugate. The conjugate was both colloidally and chemically stable in phosphate buffered solutions and could be used as a probe for magnetic resonance and fluorescent imaging.
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Pinxian
P
Xi
Kai
K
Cheng
Xiaolian
X
Sun
Zhengzhi
Z
Zeng
Shouheng
S
Sun
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry*; D004298:Dopamine / Q000008:administration & dosage / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D018613:Microscopy, Confocal; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry*; D010618:Phenanthrolines / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry
D003287:Contrast Media; D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D010618:Phenanthrolines; C517349:europium-tris(dibenzoylmethane)-1,10-phenanthroline; D011092:Polyethylene Glycols; D004298:Dopamine; D052203:Ferrosoferric Oxide