Adjuvant activity of Chinese herbal polysaccharides in inactivated veterinary rabies vaccines.
Four botanical polysaccharide preparations (from Astragalus, Echinacea, wolfberry, and kelp) were evaluated as immunopotentiators/adjuvants of a veterinary rabies vaccine. Results showed that lymphocyte proliferation and some cytokines were significantly elevated, with cellular immune responses skewed towards Th1 and Tc1. All four polysaccharides produced accelerated and enhanced effects on rabies-neutralizing antibody responses in mice and dogs. The results also indicated that certain botanical polysaccharides could be used in rabies vaccine formulations for early and persistent prophylaxis.
Laboratory of Epidemiology, Military Veterinary Research Institute, Academy of Military Medical Sciences, 666 Liuying West Road, Changchun 130122, PR China.
Ye
Y
Liu
Shoufeng
S
Zhang
Fei
F
Zhang
Rongliang
R
Hu
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D011819:Rabies Vaccines / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D011819:Rabies Vaccines; D015164:Vaccines, Inactivated