Synthetic immune signaling.
A successful immune response against pathogens requires the activation of different cell types of the immune system. These activation processes are difficult to study by classical biochemical and genetic methods alone. In this review we describe how approaches of synthetic biology, such as rebuilding of minimal functional signaling systems and the design of new molecules acting as signaling switches, can be used to get a deeper insight into the signaling mechanism of immune cells. In particular, the interaction of receptors with signal-transducing elements can be studied in detail with these new methods. In addition, sophisticated synthetic immune receptors are being tested in the clinic for gene therapy against certain cancer types.
Center for Biological Signalling Studies BIOSS and Faculty of Biology, University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. schamel@immunbio.mpg.de
Wolfgang W A
WW
Schamel
Michael
M
Reth
D006801:Humans; D007107:Immune System; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D011946:Receptors, Antigen / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D058615:Synthetic Biology / Q000379:methods*
D011946:Receptors, Antigen; D011948:Receptors, Antigen, T-Cell