Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids.
A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Yuzhu
Y
Yang
Chunsong
C
Xie
Yongju
Y
Xie
Yuhong
Y
Zhang
D000475:Alkenes / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis*; D015394:Molecular Structure
D000475:Alkenes; D001372:Aza Compounds; D002264:Carboxylic Acids; D007212:Indolizines; D003300:Copper