Cobalt and chromium ion release after large-diameter metal-on-metal total hip arthroplasty.
Seventy-five patients underwent unilateral metal-on-metal total hip arthroplasty using a large-diameter head. Serum levels of cobalt and chromium were determined. Significant increases in both cobalt and chromium were observed at 3 months (cobalt, 1.4 μg/L; chromium, 1.4 μg/L) compared with preoperative values (P < .001). At 1 year, the median cobalt and chromium levels were 2.3 and 2.1 μg/L, respectively, and the levels had increased significantly compared with 3 months (P < .001). There were no significant differences between levels of either metal at 1 or 2 years (cobalt, 2.3 μg/L; chromium, 1.6 μg/L). Pseudotumor occurred in 2 hips. Patients with large-diameter metal-on-metal total hip arthroplasty had higher circulating metal ion levels at 3 months and 1 year, with no additional significant increases at 2 years.
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.
Masahiro
M
Hasegawa
Kakunoshin
K
Yoshida
Hiroki
H
Wakabayashi
Akihiro
A
Sudo
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D002857:Chromium / Q000009:adverse effects / Q000097:blood*; D003035:Cobalt / Q000009:adverse effects / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000453:epidemiology; D006622:Hip Prosthesis; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery; D011474:Prosthesis Design; D012189:Retrospective Studies
D002857:Chromium; D003035:Cobalt