Testosterone pellet implants and migraine headaches: a pilot study.
The purpose of this prospective pilot study was to determine the therapeutic effect of continuous testosterone, delivered as a subcutaneous implant, on the severity of migraine headaches in pre- and post-menopausal patients. Twenty-seven women with a history of documented migraine headache were asked to rate their headache severity using a five-point scale at baseline (prior to therapy); and again, 3 months following treatment with testosterone implants. Improvement in headache severity was noted by 92% of patients and the mean level of improvement was statistically significant (3.3 on a 5 point scale). In addition, there was no difference in the level of improvement between pre- and post-menopausal cohorts. Seventy-four percent of patients reported a headache severity score of '0' (none) on testosterone implant therapy for the 3-month treatment period. Continuous testosterone was effective therapy in reducing the severity of migraine headaches in both pre- and post-menopausal women.
Millennium Wellness Center, 228 E. Spring Valley Road, Dayton, OH 45458, USA. rglaser@woh.rr.com
Rebecca
R
Glaser
Constantine
C
Dimitrakakis
Nancy
N
Trimble
Vincent
V
Martin
D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D000728:Androgens / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D010865:Pilot Projects; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D012720:Severity of Illness Index; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000728:Androgens; D013739:Testosterone