Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles.
Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance problem. BT-PBD hybrids and diverse BT derivatives have been synthesized and their in vitro cytotoxic activities were screened against five cancer cell lines have been discussed. The novel compounds showed promising results as compared with the marketed drug etoposide and could well be used in future anti-cancer drug development studies.
Organic & Biomolecular Chemistry Division, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India. dsb@iict.res.in
D Subhas
DS
Bose
Mohd
M
Idrees
Ismail K
IK
Todewale
N M
NM
Jakka
J Venkateswara
JV
Rao
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001569:Benzodiazepines / Q000737:chemistry; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D052160:Benzothiazoles; D001569:Benzodiazepines; D005047:Etoposide; C005465:benzothiazole