Myocardial perfusion by CT versus hybrid imaging.
Coronary computed tomography angiography (CTA) is a reliable diagnostic test for the anatomic diagnosis of obstructive coronary artery disease (CAD). Although coronary CTA shows high sensitivity and negative predictive value for detecting stenosis greater than or equal to 50% diameter, it is limited in its ability to diagnose myocardial ischemia. Advances in computed tomography (CT) technology alone and technology that hybridizes CT with single-photon emission CT and positron emission tomography allow for the combined anatomic and physiologic diagnosis of CAD. This article summarizes these combined technologies, emphasizing the merits and limitations of each technology and their clinical implications.
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 565C Carnegie Building, Baltimore, MD 21287, USA. rgeorge3@jhmi.edu
Richard T
RT
George
Vishal C
VC
Mehra
Antti
A
Saraste
Juhani
J
Knuuti
D000368:Aged; D023921:Coronary Stenosis / Q000175:diagnosis; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000209:etiology; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods; D017202:Myocardial Ischemia / Q000175:diagnosis*; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D061205:Vascular Calcification / Q000175:diagnosis