Depressed neurofilament expression associates with apolipoprotein E3/E4 genotype in maturing human fetal neurons exposed to HIV-1.
Exposure of differentiating human neural progenitor cells (NEP) to HIV-1 results in a neuronal“failure to thrive” phenotype characterized by a relative decrease in neurofilament-light (NF-L) expression. However,when NEP were segregated by their apolipoproteinE genotype, differentiating apolipoprotein E3/E4 cells showed reduced NF-L expression upon HIV-1 exposure,but differentiating apolipoprotein E3/E3 or apolipoproteinE4/E4 cells did not. These data suggest that apolipoproteinE genotype is a host factor that could affect the development of neurocognitive dysfunction in HIV-1 infected individuals.
Ricardo
R
Martinez
Wu
W
Chunjing
Rebeca
R
Geffin
Micheline
M
McCarthy
D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D002469:Cell Separation; D016207:Cytokines / Q000096:biosynthesis; D005333:Fetus; D015870:Gene Expression; D005838:Genotype; D060005:Genotyping Techniques; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D016900:Neurofilament Proteins / Q000235:genetics*; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D061251:Primary Cell Culture; D015398:Signal Transduction
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; D016207:Cytokines; D016900:Neurofilament Proteins; C044882:neurofilament protein L