[Contemporary determinations of sarcoidosis ethiopathogenesis].
Sarcoidosis is a disease about unknown etiology. It's characterized by a chronic inflammation with creation of granuloma consisted of macrophages, lymphocytes and epithelial cells. The course of the disease may be different--from spontaneous remission to severe and chronic form. The most possible cause of sarcoidosis seems to be genetic etiology. Many trials indicated strong influence of human leukocyte antigens (HLA), cytokines and chemokines on sarcoidosis origin. On the other side the role of environmental factors, viral, atypical bacterial and mycobacterial infections is strongly stressed.
Wojskowy Instytut Medyczny w Warszawie, Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii CSK MON.
Marta
M
Pacholska-Pytlakowska
Tadeusz
T
Płusa
Sławomir
S
From
D002908:Chronic Disease; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000150:complications; D012507:Sarcoidosis / Q000209:etiology* / Q000235:genetics