Prior statin use has no effect on survival after intracerebral hemorrhage in a multiethnic Asian patient cohort.
BACKGROUND
Statins have been shown to reduce mortality and morbidity in ischemic stroke, subarachnoid hemorrhage, and traumatic brain injuries, but their effect on intracerebral hemorrhage (ICH) remains to be determined. This study aimed to investigate the effect of prior statin use on survival following spontaneous primary intracerebral hemorrhage in a multi-ethnic Asian population.


METHODS
A study cohort of patients admitted with spontaneous primary ICH was obtained from our database. There were 1,381 patients who met the inclusion criteria. Multivariate logistic regression was used to identify independent predictors and computed odds ratios for 30-day mortality. Kaplan-Meier and Cox proportional hazard survival analyses were used to examine the effect of prior statin use on survival after ICH.


RESULTS
Multivariate logistic regression controlling for baseline characteristics and in-hospital interventions, did not demonstrate any effect of prior statin use (p = 0.781) on mortality. Survival analyses also failed to demonstrate any differences in survival after ICH with prior statin use. Similarly subgroup analyses showed no difference.


CONCLUSIONS
No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian patient cohort.
Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.
Nicolas K K
NK
King
Vincent Khwee-Soon
VK
Tay
John Carson
JC
Allen
Beng-Ti
BT
Ang
D000368:Aged; D044466:Asian People; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control; D015331:Cohort Studies; D018864:Cultural Diversity; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors