A domino approach of Heck coupling for the synthesis of β-trifluoromethylstyrenes.
A domino approach of Heck coupling was used to synthesize β-trifluoromethylstyrene derivatives from iodoarenes and 1-iodo-3,3,3-trifluoropropane in moderate to good yields. This method avoids the use of low-boiling, gaseous reagents such as 3,3,3-trifluoropropene, and additives and phosphines in the catalytic system.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, California 90089-1661, USA. gprakash@usc.edu
G K Surya
GK
Prakash
Hema S
HS
Krishnan
Parag V
PV
Jog
Anjali P
AP
Iyer
George A
GA
Olah
D002384:Catalysis; D017611:Fluorine Compounds / Q000138:chemical synthesis*; D008745:Methylation; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry; D020058:Styrene / Q000138:chemical synthesis*
D017611:Fluorine Compounds; D010720:Phosphines; D020058:Styrene; C044646:phosphine