Phomosines H-J, novel highly substituted biaryl ethers, isolated from the endophytic fungus Phomopsis sp. from Ligustrum vulgare.
From the endophytic fungus Phomosis sp., four known phomosines A-D (1-4) and three new phomosines H-J (5-7) have been isolated. The structures of the new compounds were determined on the basis of their spectroscopic data analysis (1H, 13C, 1H-1H COSY, HMQC, and HMBC NMR, as well as mass spectrometry). The structures of phomosine H (5) and J (7) were also confirmed by semisynthesis from phomosine A (1). The remaining four known compounds [phomosines A-D (1-4)] were identified by comparing their spectroscopic data with those reported in the literature. The four known metabolites were biologically active. Of the novel metabolites, only 6 was antifungal and antibacterial.
Department of Chemistry, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. k.krohn@upb.de
Karsten
K
Krohn
Umar
U
Farooq
Hidayat
H
Hussain
Ishtiaq
I
Ahmed
Joachim
J
Rheinheimer
Siegfried
S
Draeger
Barbara
B
Schulz
Teunis
T
van Ree
D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031659:Ligustrum / Q000382:microbiology*
D000890:Anti-Infective Agents; D004987:Ethers; C571798:phomosine H; C571799:phomosine I; C571805:phomosine J