Anti-inflammation effects of Sophora flavescens nanoparticles.
The roots of Sophora flavescens was reported to possess many pharmacological activities including anti-inflammatory, antiashmatic, antithelmintic, free radical scavenging and antimicrobial activities. However, the low saturated solubility and dissolution velocity of S. flavescens lead to poor bioavailability. The S. flavescens nanoparticles (SFNP) were prepared by a combination of ultrasound and hydrolysis developed by the authors. The drug dissolution profiles of SFNP in both pH 6.8 and pH 2 media showed complete dissolution within 30 min. The seropharmacology study showed that oral S. flavescens absorption in the SFNP was significantly increased. Anti-inflammation assay revealed the therapeutic efficiency of S. flavescens significantly enhanced upon nanoparticle formation.
School of Pharmacy, Shandong University of Tradtional Chinese Medicine, Jinan, 250355, People's Republic of China. chunchaoh@126.com
Chun-Chao
CC
Han
Yingzi
Y
Wang
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D007249:Inflammation / Q000188:drug therapy; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D053758:Nanoparticles; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis; D028321:Plant Preparations / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D029909:Sophora; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*
D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D028321:Plant Preparations; D018799:Intercellular Adhesion Molecule-1; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2