A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines.
A novel and efficient route for the preparation of quinazolin-4(3H)-imines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and nucleophile is described. The palladium-catalyzed isocyanide insertion is believed to be the key step during the reaction process.
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Guanyinsheng
G
Qiu
Gang
G
Liu
Shouzhi
S
Pu
Jie
J
Wu
D002234:Carbodiimides / Q000737:chemistry; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*
D002234:Carbodiimides; D003486:Cyanides; D007097:Imines; D011799:Quinazolines; D010165:Palladium