Unusual isomeric corniculatolides from mangrove, Aegiceras corniculatum.
Four new isomeric macrolides of combretastatin D-2 congeners named isocorniculatolide A (1), 11-O-methylisocorniculatolide A (2), 11-O-methylcorniculatolide A (3), and 12-hydroxy-11-O-methylcorniculatolide A (4), and the known corniculatolide A (5), arjunolic acid, and maslinic acid were isolated from the CHCl(3) extract of the bark of Aegiceras corniculatum. The structures of the new compounds (1-4) were elucidated by a combination of spectroscopic analysis (1-5), chemical modifications, and single-crystal X-ray analysis (1).
Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad, India 500607. pmgowri@yahoo.com
M Gowri
MG
Ponnapalli
S Ch V A Rao
SCh
Annam
Saidulu
S
Ravirala
Sushma
S
Sukki
Madhu
M
Ankireddy
V Raju
VR
Tuniki
D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D007194:India; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D029623:Primulaceae / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D009828:Oleanolic Acid / Q000031:analogs & derivatives
D001632:Bibenzyls; D018942:Macrolides; D014315:Triterpenes; C061640:arjunolic acid; C040105:combretastatin; C412811:maslinic acid; D009828:Oleanolic Acid