Functional polymorphism located in MMP-9 gene promoter is strongly associated with obesity.
The adipose tissue expansion is accompanied by remodeling of extracellular matrix performed by matrix metalloproteinases (MMPs). Higher plasma and tissue MMP-9 levels are found in obese; therefore, we evaluated if the functional C(-1562)T polymorphism (rs3918242) located in promoter region of the MMP-9 gene is associated with obesity in women. We studied 112 lean and 114 obese women. Plasma MMP-9 and tissue inhibitor of MMP-9 (TIMP)-1 were measured using enzyme-linked immunosorbent assay. We found different genotype frequencies between lean and obese women (p=0.008), prevailing T-allele in obese (2.3-fold). However, although obese women present higher levels of plasma MMP-9, lack of modulation by the polymorphism was found (all p>0.05). Our findings suggest that C(-1562)T polymorphism may contribute to pathogenetic mechanisms involved in the development of obesity in women.
Núcleo de Pós-Graduação e Pesquisa-Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil.
Vanessa L
VL
Andrade
Karla Simone
KS
Fernandes
Adriana Ap
AA
Bosco
José Eduardo
JE
Tanus-Santos
Valeria Cristina
VC
Sandrim
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*
D020780:Matrix Metalloproteinase 9