Design and synthesis of dephosphono DNA analogues containing 1,2,3-triazole linker and their UV-melting studies with DNA/RNA.
This article describes the synthesis of 3'/5' linked 1,2,3-triazolyl dithymidine derivatives, their incorporation into oligonucleotides, and evaluation of their thermal stabilities toward complementary DNA/RNA.
Division of Organic Chemistry, National Chemical Laboratory, Pune, Maharashtra, India.
Vangala
V
Madhuri
Vaijayanti A
VA
Kumar
D000577:Amides / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D009691:Nucleic Acid Denaturation; D012313:RNA / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*; D014466:Ultraviolet Rays
D000577:Amides; D014230:Triazoles; D012313:RNA; D004247:DNA