Osler-Weber-Rendu disease presenting with hepatocellular carcinoma: radiologic and genetic findings.
This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth factor-β, which plays an important role in the formation of vascular endothelia. Hepatic involvement has been reported as occurring in 30-73% of patients with HHT. However, symptomatic liver involvement is quite rare, and the representative clinical presentations of HHT in hepatic involvement are high-output heart failure, portal hypertension, nodular regenerative hyperplasia, and symptoms of biliary ischemia. Some cases of HCC in association with HHT have been reported, but are very rare. We present herein the characteristic radiologic and genetic findings of HHT that was diagnosed during the evaluation and treatment of HCC.
Department of Internal Medicine, Vievis Namuh Hospital, Seoul, Korea.
Joo Ho
JH
Lee
Yung Sang
YS
Lee
Pyo Nyun
PN
Kim
Beom Hee
BH
Lee
Gu Whan
GW
Kim
Han Wook
HW
Yoo
Nae Yun
NY
Heo
Young Suk
YS
Lim
Han Chu
HC
Lee
Young Hwa
YH
Chung
Dong Jin
DJ
Suh
D030301:Activin Receptors, Type II / Q000235:genetics; D000368:Aged; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D005091:Exons; D017353:Gene Deletion; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000628:therapy*; D008297:Male; D009154:Mutation; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D014057:Tomography, X-Ray Computed
C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II