HLA-B*07 is a high risk allele for familial cervical cancer.
OBJECTIVE
The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group.


METHODS
Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity.


RESULTS
We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1).


CONCLUSIONS
HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.
Institute of Virology, Medical School of Wuhan University, Wuhan, China. xpingqiu429@gmail.com
Xiaoping
X
Qiu
Fan
F
Zhang
Dangxiao
D
Chen
Abul Kalam
AK
Azad
Li
L
Zhang
Yulin
Y
Yuan
Zhongqing
Z
Jiang
Wenhui
W
Liu
Yun
Y
Tan
Ning
N
Tao
D000328:Adult; D000483:Alleles; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015793:HLA-B7 Antigen / Q000235:genetics*; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
D014408:Biomarkers, Tumor; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen; D000949:Histocompatibility Antigens Class II