The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications.
Multiple lines of investigation have demonstrated that the immune system plays an important role in preventing tumor initiation and controlling tumor growth. Accordingly, many cancers have evolved diverse mechanisms to evade such monitoring. While multiple immune cell types mediate tumor surveillance, recent evidence demonstrates that macrophages, and other phagocytic cells, play a key role in regulating tumor growth through phagocytic clearance. In this review we highlight the role of tumor immune evasion through the inhibition of phagocytosis, specifically through the CD47-signal-regulatory protein-α pathway, and discuss how targeting this pathway might lead to more effective cancer immunotherapies.
Institute for Stem Cell Biology and Regenerative Medicine and Cancer Institute, Stanford, CA 94305, USA. mpchao@stanford.edu
Mark P
MP
Chao
Irving L
IL
Weissman
Ravindra
R
Majeti
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D051928:CD47 Antigen / Q000276:immunology / Q000378:metabolism; D006801:Humans; D057131:Immune Evasion; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D011971:Receptors, Immunologic / Q000276:immunology; D015398:Signal Transduction
D000943:Antigens, Differentiation; D051928:CD47 Antigen; D011971:Receptors, Immunologic