Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs.
Amidase-catalyzed desymmetrization of meso-N-heterocyclic dicarboxamides under very mild conditions provided a highly efficient and practical method for the preparation of enantiomerically pure carbamoyl-substituted heterocyclic amino acids that were unique and versatile platforms for the construction of both antipodes of aza-sugar containing nucleoside analogs.
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Peng
P
Chen
Ming
M
Gao
De-Xian
DX
Wang
Liang
L
Zhao
Mei-Xiang
MX
Wang
D000577:Amides / Q000378:metabolism*; D000581:Amidohydrolases / Q000378:metabolism; D001372:Aza Compounds / Q000378:metabolism; D055162:Biocatalysis; D001711:Biotransformation; D009705:Nucleosides / Q000378:metabolism*; D012240:Rhodococcus / Q000378:metabolism*; D013237:Stereoisomerism
D000577:Amides; D001372:Aza Compounds; D009705:Nucleosides; D000581:Amidohydrolases; C019665:amidase