Bral1: "Superglue" for the extracellular matrix in the brain white matter.
Bral1 is a link protein that stabilizes the binding between lecticans and hyaluronic acid and thus maintains the extracellular matrix assembly in the CNS. Bral1 is specifically located in the white matter around the nodes of Ranvier. Recent studies suggest its function in promoting saltatory neural conduction. This article reviews the current knowledge about the structure, expression and function of this link protein.
Department of Neuroscience and Center for Cell Therapy and Tissue Repair, 2nd Faculty of Medicine, Charles University, V úvalu 84, 150 06 Prague 5, Czech Republic.
Michal
M
Cicanic
Eva
E
Sykova
Lydia
L
Vargova
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*
D009419:Nerve Tissue Proteins