HNF1B and endometrial cancer risk: results from the PAGE study.
We examined the association between HNF1B variants identified in a recent genome-wide association study and endometrial cancer in two large case-control studies nested in prospective cohorts: the Multiethnic Cohort Study (MEC) and the Women's Health Initiative (WHI) as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. A total of 1,357 incident cases of invasive endometrial cancer and 7,609 controls were included in the analysis (MEC: 426 cases/3,854 controls; WHI: 931 cases/3,755 controls). The majority of women in the WHI were European American, while the MEC included sizable numbers of African Americans, Japanese and Latinos. We estimated the odds ratios (ORs) per allele and 95% confidence intervals (CIs) of each SNP using unconditional logistic regression adjusting for age, body mass index, and four principal components of ancestry informative markers. The combined ORs were estimated using fixed effect models. Rs4430796 and rs7501939 were associated with endometrial cancer risk in MEC and WHI with no heterogeneity observed across racial/ethnic groups (P ≥ 0.21) or between studies (P ≥ 0.70). The OR(per allele) was 0.82 (95% CI: 0.75, 0.89; P = 5.63 × 10(-6)) for rs4430796 (G allele) and 0.79 (95% CI: 0.73, 0.87; P = 3.77 × 10(-7)) for rs7501939 (A allele). The associations with the risk of Type I and Type II tumors were similar (P ≥ 0.19). Adjustment for additional endometrial cancer risk factors such as parity, oral contraceptive use, menopausal hormone use, and smoking status had little effect on the results. In conclusion, HNF1B SNPs are associated with risk of endometrial cancer and that the associated relative risks are similar for Type I and Type II tumors.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Veronica Wendy
VW
Setiawan
Jeffrey
J
Haessler
Fredrick
F
Schumacher
Michele L
ML
Cote
Ewa
E
Deelman
Megan D
MD
Fesinmeyer
Brian E
BE
Henderson
Rebecca D
RD
Jackson
Jens-S
JS
Vöckler
Lynne R
LR
Wilkens
Shagufta
S
Yasmeen
Christopher A
CA
Haiman
Ulrike
U
Peters
Loïc
L
Le Marchand
Charles
C
Kooperberg
D000368:Aged; D018269:Carcinoma, Endometrioid / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005828:Genetics, Population; D051539:Hepatocyte Nuclear Factor 1-beta / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology
C496495:HNF1B protein, human; D051539:Hepatocyte Nuclear Factor 1-beta