Synthesis, DNA binding, and cleavage studies of Co(III) complexes with fused aromatic NO/NN-containing ligands.
Four new Co(III) complexes, namely [Co(cq)(3)](PF(6))(3), [Co(phen)(2)(cq)](PF(6))(3), [Co(bnp)(3)] (PF(6))(3), and [Co(phen)(2)(bnp)](PF(6))(3) (where cq = chromeno[2,3-b]quinoline, phen = 1,10-phenanthroline and bnp = dibenzo[b,g][1,8]naphthyridine), were synthesized and structurally characterized. Spectroscopic data suggested an octahedral geometry for all the complexes. Binding studies of these complexes with double-stranded (ds)DNA were analyzed by absorption spectra, viscosity, and thermal denaturation studies. The results revealed that the metal complex intercalates into the DNA base stack as intercalator. The oxidative cleavage activities of the complexes were studied with supercoiled pUC19 DNA using gel electrophoresis and the results show that the complexes have potent nuclease activity.
Department of Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta, Karnataka, India.
Chittanahalli N
CN
Sudhamani
Halehatty S
HS
Bhojya Naik
D
D
Girija
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D003035:Cobalt / Q000737:chemistry* / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism; D007364:Intercalating Agents / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
D056831:Coordination Complexes; D004278:DNA, Superhelical; D007364:Intercalating Agents; D008024:Ligands; D009287:Naphthyridines; D010618:Phenanthrolines; D011804:Quinolines; D003035:Cobalt; D004247:DNA; C025205:1,10-phenanthroline