Comparison of the various lipid ratios and indices for risk assessment in patients of myocardial infarction.
OBJECTIVE
Coronary artery disease (CAD) has emerged as the major cause of morbidity and mortality among Asian Indians in the recent past. The following study was undertaken to assess the predictive value of novel biomarkers of dyslipidemia for risk assessment for CAD in the Indian population.


METHODS
The study group comprised of 100 clinically assessed patients of myocardial infarction and 100 age and sex matched healthy controls. Apolipoprotein-A (Apo-AI) and Apolipoprotein-B (Apo-B) were estimated and small dense LDL was derived mathematically.


RESULTS
The cases showed significantly high levels of total serum cholesterol, triglycerides, LDL cholesterol, Apo-B, sdLDL, and non-HDL cholesterol. On carrying out multivariate regression analysis, Lp(a)/HDL ratio emerged as the best determinant of CAD risk


CONCLUSIONS
The above data clearly underlines the role of these novel biomarkers in the risk assessment for CAD in the Indian context.
Department of Biochemistry, Lady Hardinge Medical College & Associated hospitals, New Delhi-110001, India. binita.dr@gmail.com
Binita
B
Goswami
Medha
M
Rajappa
Baidarbhi
B
Chakraborty
S K
SK
Patra
Suresh
S
Kumar
V
V
Mallika
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007194:India; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology; D016017:Odds Ratio; D011804:Quinolines; D012372:ROC Curve; D012044:Regression Analysis; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D011804:Quinolines; D014280:Triglycerides; D002784:Cholesterol; C117172:AU 006