[The clinic value of (18)F-FDG PET/CT imaging in differentiation of malignant from benign disease in lung].
OBJECTIVE
To evaluate the clinic value of (18)F-FDG PET/CT imaging in differentiation of malignant from benign disease in lung.


METHODS
188 patients underwent (18)F-FDG 45 min early and 2 h delayed PET/CT imaging after intravenous injection of (18)F-FDG. The standardized uptake value (SUV) and retention index (RI) of region of interesting were calculated. The histological diagnosis or clinical findings in a 12 months follow-up period served as the standard of truth.


RESULTS
In 114 patients with malignant disease and 74 patients with benign disease, the sensitivity, speciality and accuracy of (18)F-FDG PET/CT imaging in differentiation of malignant from benign lung nodules (diameter more than 10 mm) were 98.2%, 80.0%, and 96.6%, in mediastinal lymph nodes and were 95.7%, 41.7%, and 84.8%, respectively. The sensitivity of (18)F-FDG PET imaging for lung nodules (diameter less than 10 mm) was lower than CT.


CONCLUSIONS
Integrated PET/CT imaging provides high sensitivity, specificity and reasonably high accuracy for lung cancer.
The First Affiliated Hospital of Soochow University, Dept. of Oncology, Department of Nuclear Medicine, Suzhou Municipal Hospital, Suzhou 215006, China.
Zhen-Xin
ZX
Wang
Bin
B
Zhang
Yi-Wei
YW
Wu
Bin
B
Ni
Lü-de
LD
Pan
D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18