Advances in the understanding of the aetiology of Dupuytren's disease.
Dupuytren's disease is a fibroproliferative disease of the palmar fascia which has been described for centuries, yet the aetiology and pathophysiology remain poorly understood. Surgery and collagenase injections comprise the main therapeutic options but disease recurrence is common. We explore the evidence underlying the current disease theories and outline other potential therapeutic options.
Royal National Orthopaedic Hospital, Stanmore, Middx HA7 4LP, UK.
Natasha E
NE
Picardo
Wasim S
WS
Khan
D017364:Collagenases / Q000008:administration & dosage*; D004387:Dupuytren Contracture / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D005205:Fascia / Q000503:physiopathology; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D019637:Orthopedic Procedures / Q000379:methods*; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D017364:Collagenases