Menstrual cycle effects on the action of buspirone on food intake in healthy female volunteers.
We studied the effect of single doses of the 5-HT(1A) agonist buspirone (10 mg and 20 mg) on food intake during the menstrual cycle of nine healthy women, none of whom were on a contraceptive pill. In a double-blind placebo-controlled trial, subjects were tested over three cycles, receiving one treatment per cycle. Within each cycle, they were tested at two time points; mid-follicular and late luteal. Food intake following 20 mg buspirone was significantly higher in the luteal phase, suggesting the possibility of pre-menstrually enhanced 5-HT receptor sensitivity.
Formerly Academic Unit of Human Psychopharmacology, Department of Psychological Medicine, Medical College of St Bartholomew's Hospital, London EC1A 7BE, Psychopharmacology Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK.
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EM
Goodall
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Whittle
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J
Cookson
P J
PJ
Cowen
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Silverstone