MicroRNAs regulate osteogenesis and chondrogenesis.
MicroRNAs (miRNAs) are a class of small molecules and non-coding single strand RNAs that regulate gene expression at the post-transcriptional level by binding to specific sequences within target genes. miRNAs have been recognized as important regulatory factors in organism development and disease expression. Some miRNAs regulate the proliferation and differentiation of osteoblasts, osteoclasts and chondrocytes, eventually influencing metabolism and bone formation. miRNAs are expected to provide potential gene therapy targets for the clinical treatment of metabolic bone diseases and bone injuries. Here, we review the recent research progress on the regulation of miRNAs in bone biology, with a particular focus on the miRNA-mediated control mechanisms of bone and cartilage formation.
Laboratory of Biomechanics, Department of Anatomy, The Third Military Medical University, Chongqing, China. shiwudong@gmail.com
Shiwu
S
Dong
Bo
B
Yang
Hongfeng
H
Guo
Fei
F
Kang
D019902:Chondrocytes / Q000378:metabolism; D020219:Chondrogenesis / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D010003:Osteoarthritis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism; D010012:Osteogenesis / Q000235:genetics*
D035683:MicroRNAs