The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.
BACKGROUND
The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).


METHODS
A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF -173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects.


RESULTS
Ten comparative studies, consisting of nine European, and one Turkish population, were included in  his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205-1.427, P < 1 × 10(-8)]. In addition, meta-analysis revealed an association between the C allele of the MIF -173 C/G polymorphism and JIA in all subjects (OR 1.482, 95% CI 1.202-1.828, P = 2.3 × 10(-4)).


CONCLUSIONS
This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF -173 C/G polymorphism may be associated with susceptibility to JIA.
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seongbuk-gu, Seoul. lyhcgh@korea.ac.kr
Young Ho
YH
Lee
Sang-Cheol
SC
Bae
Gwan Gyu
GG
Song
D001171:Arthritis, Juvenile / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D011110:Polymorphism, Genetic; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*
D008263:Macrophage Migration-Inhibitory Factors; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human