A new human (psycho)pharmacology tool: the multiple organs coincidences counter (MOCC).
We describe a novel instrument which is capable of measuring the uptake of radioligand in human organs in  vivo with the administration of very small doses of positron-emitting radioligands. This technique readily detects the displacement or reduced uptake of radioligand when a competitive agonist or antagonist is administered. This system provides no tomographic information, but the small radioactive doses involved mean that investigations can be repeated at regular intervals and that female volunteers can also participate. We administered [(11) C]flumazenil, [(11)C]diprenorphine, [(11)C]meta -hydroxyephedrine (MHED) and [(11)C]RTI 55 to healthy male volunteers and performed control, pre-loading and displacement experiments. These demonstrate the feasibility of using this technique to investigate benzodiazepine and opiate receptor occupancy, as well as occupancy at dopamine, noradrenaline and serotonin (5-HT) re-uptake sites. This method is likely to be useful in pharmacokinetic/pharmacodynamic experiments, in drug development and discovery and in the development of novel imaging radioligands.
Methodology and Neuroscience Sections, MRC Cyclotron Unit, Hammersmith Hospital, London W12 0HS, Psychopharmacology Unit, University of Bristol, Bristol BS8 1TD, UK.
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Malizia
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Forse
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Haida
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Gunn
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Melichar
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Poole
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Bateman
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Fahy
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Schnorr
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Brown
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Rhodes
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Nutt
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Jones