Total and bone-specific alkaline phosphatases in haemodialysis patients with chronic liver disease.
OBJECTIVE
The Kidney Disease: Improving Global Outcomes "KDIGO" recommends regular sampling of bone turnover markers (BTMs) such as total alkaline phosphatases (t-ALP) and bone-specific alkaline phosphatase (b-ALP) in the case of haemodialysis (HD) patients.


METHODS
We present our results of the regular assessment of t-ALP, b-ALP, and PTH, obtained for existing HD patients with chronic liver disease (LD).


RESULTS
76 prevalent HD patients were examined. Linear regression showed that b-ALP and t-ALP levels were closely related (r²: 0.6; p<0.0001), even when the serum PTH level was <250 pg/mL (r²: 0.56; p<0.001). The b-ALP/t-ALP ratio was 0.07 ± 0.12 and correlated poorly with PTH levels (r²: 0.03; p=0.01). Both b-ALP and t-ALP levels did not correlated with PTH levels.


CONCLUSIONS
Our results did not confirm the KDIGO recommendation for using b-ALP as BTM in the special cases of HD patients with LDs.
NEPHROCARE Tassin-Charcot, Sainte Foy-Les-Lyon, France. guillaume-jean-crat@wanadoo.fr
Guillaume
G
Jean
Jean-Claude
JC
Souberbielle
Eric
E
Zaoui
Christie
C
Lorriaux
Brice
B
Mayor
Jean-Marc
JM
Hurot
Patrick
P
Deleaval
Charles
C
Chazot
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000201:enzymology*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D016014:Linear Models; D008107:Liver Diseases / Q000097:blood / Q000201:enzymology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis
D015415:Biomarkers; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase