Industrial toxicants and Parkinson's disease.
The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson's disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.
Department of Environmental Health, Rollins School of Public Health, Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, United States. William.m.caudle@emory.edu
W Michael
WM
Caudle
Thomas S
TS
Guillot
Carlos R
CR
Lazo
Gary W
GW
Miller
D004781:Environmental Exposure; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors
D015386:Hazardous Substances