Salivary lactate dehydrogenase levels in oral leukoplakia and oral squamous cell carcinoma: a biochemical and clinicopathological study.
BACKGROUND
Oral cancer is the third most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Transformation of normal tissue to premalignant lesion and further to oral cancer results in alteration in glycolytic pathway and hence the lactate dehydrogenase levels. Therefore, a study was carried out to determine the changes in the salivary alterations in lactate dehydrogenase (LD) levels oral leukoplakia (OL) and oral cancer (OC).


METHODS
Seventy-five patients reporting to department of oral medicine and radiology, were enrolled into the study which includes 25 patients each of oral leukoplakia, 25 of oral cancer and 25 healthy controls (HC). Unstimulated whole saliva measuring 1 mL will be collected from each of these patients by spit method in centrifuged and evaluated for LDH levels using the standard kit method. The data obtained were subjected to statistical analysis using the SPSS software version 17.


RESULTS
The mean salivary lactate dehydrogenase levels were higher in males in comparison to females in all three study groups OL, OC and HC. The salivary lactate dehydrogenase levels in the controls group, oral leukoplakia group and oral cancer were 79.50 ± 4.67 IU/L, 136.46 ± 3.36 IU/L and 148.77 ± 4.83 IU/L, respectively. There was a significant difference in the mean salivary levels of the above groups.


CONCLUSIONS
Salivary lactate dehydrogenase levels are consistently higher in oral precancer and cancer hence it could be future marker.
Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University, University Enclave, Deralakatte, Mangalore, Karnataka, India. drshishirshettyomr@yahoo.com
Shishir Ram
SR
Shetty
Raunaq
R
Chadha
Subhas
S
Babu
Suchetha
S
Kumari
Supriya
S
Bhat
Sonika
S
Achalli
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis* / Q000378:metabolism; D007972:Leukoplakia, Oral / Q000378:metabolism*; D008297:Male; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D012463:Saliva / Q000737:chemistry*; D055815:Young Adult
D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase