The 5-HT(7) receptor antagonist SB 269970 counteracts restraint stress-induced attenuation of long-term potentiation in rat frontal cortex.
The effects of restraint lasting for 10 min, repeated twice daily for 3 days, were studied ex vivo in rat frontal cortex slices prepared 24 h after the last stress session. In slices originating from stressed animals, the amplitude of extracellular field potentials recorded in cortical layer II/III was increased. Stress also resulted in a reduced magnitude of long-term potentiation (LTP) of field potentials. In a separate experimental group, rats were subjected to restraint lasting for 10 min, twice daily for 3 days but, additionally, animals received injections of 5-HT(7) receptor antagonist SB 269970 (1.25 mg/kg) before each restraint stress session. In this group, the amplitude of field potentials and the magnitude of LTP were not different from the control, indicating that stress-induced modifications of basal glutamatergic transmission and synaptic plasticity were prevented by the 5-HT(7) receptor antagonist.
Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland. nftokars@cyf-kr.edu.pl
K
K
Tokarski
B
B
Bobula
M
M
Kusek
G
G
Hess
D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology; D012149:Restraint, Physical / Q000009:adverse effects / Q000523:psychology; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use
D010636:Phenols; D011985:Receptors, Serotonin; C404922:SB 269970; D012702:Serotonin Antagonists; D013449:Sulfonamides; C104425:serotonin 7 receptor