Therapeutic case conference from Northwestern: an elderly gentleman with an unsteady gait.
We provide a Therapeutic Conference from Northwestern based on the case of a 63-year-old man who presented with cerebellar ataxia in the setting of a negative workup for a cerebrovascular event, toxic-metabolic, and infectious etiologies and was ultimately diagnosed with a paraneoplastic syndrome secondary to limited-stage small cell lung cancer. A discussion of the clinical management including diagnostic workup and treatment of cerebellar ataxia paraneoplastic syndrome and limited-stage small cell lung cancer is provided. We also discuss the mechanisms of action of chemotherapy used to treat limited-stage small cell lung cancer and potential side effects associated with these agents.
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. n-vidula@fsm.northwestern.edu
Neelima
N
Vidula
Melissa
M
Johnson
Aashish
A
Didwania
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents