Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
School of Chemistry, University of Leeds, UK.
Diana C F
DC
Monteiro
Roger M
RM
Phillips
Benjamin D
BD
Crossley
Jake
J
Fielden
Charlotte E
CE
Willans
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry*
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; C030011:carbene; D012834:Silver; D008697:Methane