[Effect of accelerated heavy ions of carbon 12C, neon 20Ne and iron 56Fe on the chromosomal apparatus of human blood lymphocytes in vitro].
Cytogenetic assay of the chromosomal apparatus of human blood lymphocytes was carried out after in vitro irradiation by heavy charged particles with high LET values. Blood plasm samples enriched with lymphocytes were irradiated by accelerated ions of carbon 12C (290 MeV/nucleon and LET = 70 keV/microm), neon 20Ne (400 MeV/nucleon and LET = 70 keV/microm), and iron 56Fe (500 MeV/nucleon and LET = 200 keV/microm) in the dose range from 0.25 to 1 Gy. Rate of chromosome aberrations showed a linear dependence on doses from the densely ionizing radiations with high LET values. Frequency of dicentrics and centric rings in human lymphocytes irradiated by 12C with the energy of 290 MeV/nucleon was maximal at 1 Gy (p < 0.05) relative to the other heavy particles. It was found that relative biological effectiveness of heavy nuclei is several times higher than of 60Co gamma-radiation throughout the range of doses in this investigation.
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D000328:Adult; D002244:Carbon / Q000009:adverse effects; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002875:Chromosomes / Q000528:radiation effects* / Q000648:ultrastructure; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D020450:Heavy Ions / Q000009:adverse effects*; D006801:Humans; D007501:Iron / Q000009:adverse effects; D018499:Linear Energy Transfer; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D009356:Neon / Q000009:adverse effects; D011839:Radiation, Ionizing; D012062:Relative Biological Effectiveness; D013026:Space Flight; D018561:Space Simulation
D009356:Neon; D002244:Carbon; D007501:Iron