Effects of different adrenergic blockades on the stress resistance of Wistar rats.
The coordinated responses of the sympathoadreno-medullary (SAM) system and hypothalamic-pituitary-adrenal (HPA) axis could improve the organism's capacity to cope with stress, but its underlying mechanism is still unclear. In the present study, 32 Wistar rats were employed and divided into four groups: control, CUMS, PROP and PRAZ. After the chronic unpredicted mild stress (CUMS) model was built in the latter three groups, all animals were exposed to inescapable footshock. We found that α(1)-adrenoceptor antagonist prazosin (PRAZ) administration could improve behavior changes, reduce the cellular impairment in brain and inhibit the hyperfunction of HPA axis induced by CUMS exposure. Moreover, it decreased the heat shock protein 70 and inducible nitric oxide synthase expression in different brain areas as subsequently exposed to acute stress. In conclusion, α1-adrenoceptor may play a major role in regulating the coordinated responses between two physiological axes and improve the stress resistance.
Institute of Medical Psychology, Shandong University Medical School, Jinan 250012, PR China.
Le Jin
LJ
Yang
Xin
X
Liu
De Xiang
DX
Liu
Hong
H
Jiang
Xue Qin
XQ
Mao
Chao
C
Wang
Fang
F
Pan
D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006624:Hippocampus / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000201:enzymology / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000502:physiology*
D058668:Adrenergic alpha-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D018840:HSP70 Heat-Shock Proteins; D011433:Propranolol; D052247:Nitric Oxide Synthase Type II; D003345:Corticosterone; D011224:Prazosin