Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach.
Hydrogen sulfide (H(2)S), nitric oxide (NO) and nitrite (NO(2)(-)) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H(2)S in the whole-body responses to hypoxia.
Zoophysiology, Department of Bioscience, Aarhus University, Aarhus C, Denmark. angela.fago@biology.au.dk
Angela
A
Fago
Frank B
FB
Jensen
Bruno
B
Tota
Martin
M
Feelisch
Kenneth R
KR
Olson
Signe
S
Helbo
Sjannie
S
Lefevre
Daniele
D
Mancardi
Anna
A
Palumbo
Guro K
GK
Sandvik
Nini
N
Skovgaard
D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000502:physiology; D009573:Nitrites / Q000378:metabolism*; D015398:Signal Transduction
D009573:Nitrites; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D006862:Hydrogen Sulfide