[Clinical manifestation of Lyme borreliosis in children with positive and negatiwe western blot results].
BACKGROUND
In the afforested area of North-Eastern Poland the risk of Borrelia burgdorferi infection seems to be higher compared to the other regions. Because of unspecific clinical manifestation of Lyme borreliosis in children the positive ELISA IgM results should be confirmed with Western blot IgM tests.


OBJECTIVE
Retrospective analysis of clinical signs and symptoms of Lyme borreliosis in children with positive ELISA IgM and positive Western blot IgM results and in children with positive ELISA IgM and negative Western blot IgM results.


METHODS
The study included 20 children reactive with ELISA IgM (Bellco Biomedica, Austria), hospitalized in Pediatric Infectious Diseases Clinic in 2007 due to probable diagnosis of Lyme disease. All children were tested with B. burgdorferi Western blot IgM and/or IgG assay (DRG, Diagnostics, Germany) as a second-step diagnosis. In 10 (50% females, 50% males) out of 20 children the results were positive (borreliosis) and in other 10 (80% females, 20% males) the results were negative (controls). In both groups of patients the retrospective analysis of signs and symptoms was done.


RESULTS
The most often clinical manifestation of Lyme borreliosis in children was neuroborreliosis. Children presented Lyme meningitis (30%), facial nerve palsy (10%) and chronic or recurrent headaches (40%), associated with vertigo (20%), weakness (30%), fever (40%), and fatigue syndrome (30%). One patient presented Lyme arthritis. Children of control group presented with unspecific symptoms like isolated headaches (40%), arthralgias (70%), myalgias (10%) and abdomen pain (20%)


CONCLUSIONS
(1) The most frequent clinical presentation of Lyme borreliosis in analyzed children was neuroborreliosis; (2) Isolated arthralgias in children reactive with B. burgdorferi ELISA IgM need to be confirmed with Western blot assay before implementing the antibiotic therapy.
Klinika Obserwacyjno-Zakaźna Dzieci Uniwersytetu Medycznego w Białymstoku.
Elzbieta
E
Ołdak
Doroto
D
Rozkiewicz
Artur
A
Sulik
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D015153:Blotting, Western / Q000379:methods; D015748:Borrelia burgdorferi Group / Q000276:immunology / Q000302:isolation & purification*; D002648:Child; D015897:Comorbidity; D005158:Facial Paralysis / Q000453:epidemiology; D005260:Female; D006261:Headache / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008193:Lyme Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D020852:Lyme Neuroborreliosis / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D018908:Muscle Weakness / Q000453:epidemiology; D009422:Nervous System Diseases / Q000453:epidemiology; D011044:Poland; D012189:Retrospective Studies; D012698:Serologic Tests
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M