Glycine catalyzed convenient synthesis of 2-amino-4H-chromenes in aqueous medium under sonic condition.
A one-pot three-component condensation of an aldehyde, malononitrile, and resorcinol has been achieved by ultrasound method. The reaction has been catalyzed by glycine in aqueous medium. This protocol afforded corresponding 2-amino-4H-chromenes in shorter reaction times, high yields and simple work-up procedures with the green aspects by avoiding toxic reagents.
Department of Studies in Chemistry, Bangalore University, Central College Campus, Palace Road, Bengaluru 560001, India.
Bandita
B
Datta
M A
MA
Pasha
D000447:Aldehydes / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005998:Glycine / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D012118:Resorcinols / Q000737:chemistry; D013010:Sonication; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D001578:Benzopyrans; D009570:Nitriles; D012118:Resorcinols; D014867:Water; C000945:dicyanmethane; D005998:Glycine; C031389:resorcinol