Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression.
The tumor microenvironment is a complex milieu of tumor and host cells. Host cells can include tumor-reactive T cells capable of killing tumor cells. However, more frequently the tumor and host components interact to generate a highly immune suppressive environment that frustrates T cell cytotoxicity and promotes tumor progression through a variety of immune and non-immune mechanisms. Myeloid-derived suppressor cells (MDSC) are a major host component contributing to the immune suppressive environment. In addition to their inherent immune suppressive function, MDSC amplify the immune suppressive activity of macrophages and dendritic cells via cross-talk. This article will review the cell-cell interactions used by MDSC to inhibit anti-tumor immunity and promote progression, and the role of inflammation in promoting cross-talk between MDSC and other cells in the tumor microenvironment.
University of Maryland Baltimore County, Department of Biological Sciences, Baltimore, MD 21250, United States. srosenbe@umbc.edu
Suzanne
S
Ostrand-Rosenberg
Pratima
P
Sinha
Daniel W
DW
Beury
Virginia K
VK
Clements
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation; D018836:Inflammation Mediators / Q000378:metabolism; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D019139:Tumor Escape; D059016:Tumor Microenvironment / Q000276:immunology
D018836:Inflammation Mediators