Design of photocontrolled RNA-binding peptidomimetics.
Positively constrained: the first examples of photocontrolled RNA binding peptides are described. The large number of positively charged sides chains in the Rev response element (RRE) of an HIV type I targeting α-helix imposes constraints on the choice of azobenzene-derived crosslinker.
School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Robert J
RJ
Mart
Piotr
P
Wysoczański
Sabine
S
Kneissl
Antonio
A
Ricci
Andrea
A
Brancale
Rudolf K
RK
Allemann
D001391:Azo Compounds / Q000737:chemistry; D001665:Binding Sites; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D057786:Peptidomimetics / Q000528:radiation effects*; D055668:Photochemical Processes; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D001391:Azo Compounds; D003432:Cross-Linking Reagents; D010455:Peptides; D057786:Peptidomimetics; D011506:Proteins; D012313:RNA; C009850:azobenzene