[Network pharmacology study on major active compounds of Fufang Danshen formula].
OBJECTIVE
To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases.


METHODS
Literature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone II(A), salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software.


RESULTS
AND CONCLUSION: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e. g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.
Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China.
Xiang
X
Li
Leihong
L
Wu
Xiaohui
X
Fan
Boli
B
Zhang
Xiumei
X
Gao
Yi
Y
Wang
Yiyu
Y
Cheng
D000818:Animals; D004194:Disease / Q000235:genetics; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*; D053263:Gene Regulatory Networks; D006801:Humans; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; C517866:fufang danshen