How to activate a gene: decap its associated noncoding RNA.
Capped and polyadenylated long noncoding RNAs (lncRNAs) are shown to be degraded by a DCP2-mediated turnover mechanism by Geisler et al. (2012); this provides a new level of regulatory control for inducible genes by lncRNAs.
Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0695, USA.
Madhuvanthi
M
Ramaiah
Eleen Y
EY
Shum
Miles F
MF
Wilkinson
D005095:Exoribonucleases / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D012315:RNA Caps / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D022661:RNA, Untranslated / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*
D012315:RNA Caps; D022661:RNA, Untranslated; D029701:Saccharomyces cerevisiae Proteins; C075577:RAT1 protein, S cerevisiae; D005095:Exoribonucleases