Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells.
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as regenerative therapeutics. Cultured MSCs secrete various modulatory factors, which contribute to the immunosuppressive effects of transplanted MSCs as a therapy. Although the in vitro phenotype of MSCs has been well characterized, identification of MSCs in vivo is made difficult by the lack of specific markers. Current advances in murine MSC research provide valuable tools for studying the localization and function of MSCs in vivo. Recent findings suggest that MSCs exert diverse functions depending on tissue context and physiological conditions. This review focuses on bone marrow MSCs and their roles in haematopoiesis and immune responses.
Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. cshi@rockefeller.edu
Chao
C
Shi
D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology* / Q000502:physiology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D006410:Hematopoiesis / Q000276:immunology* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000276:immunology* / Q000502:physiology; D051379:Mice
D018925:Chemokines