Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons.
1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2. Minocycline but not memantine or glycoconjugate protected cultured cells and warrants further investigation.
Laboratory of Neurodegenerative Diseases, Department of Anatomy, Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
S Y
SY
Yik
M S
MS
Yu
Y S
YS
Ho
C S W
CS
Lai
Y T
YT
Cheung
K F
KF
So
R C C
RC
Chang
D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D004672:Encephalitis, Japanese / Q000150:complications; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006001:Glycoconjugates / Q000494:pharmacology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008559:Memantine / Q000494:pharmacology; D008911:Minocycline / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D012330:RNA, Double-Stranded
D000900:Anti-Bacterial Agents; D018691:Excitatory Amino Acid Antagonists; D006001:Glycoconjugates; D018696:Neuroprotective Agents; D012330:RNA, Double-Stranded; D007770:L-Lactate Dehydrogenase; D053148:Caspase 3; D008911:Minocycline; D008559:Memantine