Cu(I)-catalyzed (11)C carboxylation of boronic acid esters: a rapid and convenient entry to (11)C-labeled carboxylic acids, esters, and amides.
Rapid and direct: the carboxylation of boronic acid esters with (11)CO(2) provides [(11)C]carboxylic acids as a convenient entry into [(11)C]esters and [(11)C]amides. This conversion of boronates is tolerant to diverse functional groups (e.g., halo, nitro, or carbonyl).
Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, UK. pr340@wbic.cam.ac.uk
Patrick J
PJ
Riss
Shuiyu
S
Lu
Sanjay
S
Telu
Franklin I
FI
Aigbirhio
Victor W
VW
Pike
D000577:Amides / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters; D007553:Isotope Labeling
D000577:Amides; D001897:Boronic Acids; D002250:Carbon Radioisotopes; D002264:Carboxylic Acids; D004952:Esters; D002245:Carbon Dioxide; D003300:Copper