New antifungal cholestane and aldehyde derivatives from the red alga Laurencia papillosa.
The chloroform/methanol extract of the red alga, Laurencia papillosa, collected from the Red Sea in Saudi Arabia, was found to contain two cholestane derivatives: 3alpha, 6alpha-dihydroxy-5beta-cholestan-12-one (1) and the known, 6beta-hydroxycholest-4-en-3-one (2), which was isolated separately in a pure form for the first time. In addition to these compounds, a new aldehyde derivative, (E)-2-{(E) tridec-2-en-2-yl} heptadec-2-enal (3), was isolated. The structures of all compounds were established based on extensive spectroscopic (1D and 2D NMR, UV, IR) and mass spectrometric studies. All compounds, except 2, were tested for their antifungal activity. Significant activities were associated with 1 and 3 against Candida albicans, Aspergillus fumigatus, and A. flavus.
Department of Marine Chemistry, Faculty of Marine Sciences, King AbdulAziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia. waliedl1737@yahoo.com
Walied M
WM
Alarif
Sultan S
SS
Al-Lihaibi
Ahmed
A
Abdel-Lateff
Seif-Eldin N
SE
Ayyad
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D000461:Rhodophyta / Q000737:chemistry*
D000447:Aldehydes; D000935:Antifungal Agents; D002776:Cholestanes