[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases].
OBJECTIVE
To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine.


METHODS
Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC.


RESULTS
The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively.


CONCLUSIONS
The new base benefits the lipophilic drugs and releases more stably.
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Xiaoping
X
Yan
Shijie
S
Guan
Rui
R
Zheng
Bowen
B
Yi
Yonggang
Y
Wang
Yonghong
Y
Zhu
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D010539:Permeability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D004365:Drugs, Chinese Herbal