Highly regio- and stereoselective ruthenium(II)-catalyzed direct ortho-alkenylation of aromatic and heteroaromatic aldehydes with activated alkenes under open atmosphere.
Various aromatic and heteroaromatic aldehydes reacted with activated alkenes in the presence of a catalytic amount of [{RuCl(2)(p-cymene)}(2)], AgSbF(6), and Cu(OAc)(2)·H(2)O to give substituted alkene derivatives in a highly regio- and stereoselective manner. The corresponding alkene derivatives were further converted into unusual four-membered cyclic ketones or a polycyclic isochromanone derivative via a photochemical rearrangement. Notably, the catalytic reaction was conducted under an open atmosphere.
Department of Chemistry, Indian Institute of Science Education and Research, Pune 411021, India.
Kishor
K
Padala
Masilamani
M
Jeganmohan