Multiple eruptive pilomatricomas in a 9-year-old boy with glioblastoma.
A 9-year-old male presented to our dermatology clinic with a recent history of developing numerous cutaneous pilomatricomas, and was subsequently discovered to have sustained a recurrence of his glioblastoma multiforme. Immunohistochemical staining of a representative pilomatricoma and his original brain tumor revealed upregulation and nuclear localization of beta-catenin, a sign associated with poor prognosis in glioblastoma. We hypothesize that the development of multiple pilomatricomas may have been a hallmark of this patient's tumor recurrence and provide support for a recent report of an association between multiple pilomatricomas and gliomatosis cerebri.
Departments of DermatologyPathology, Stanford University, Palo Alto, California.
S Tyler
ST
Hollmig
Megha M
MM
Tollefson
Jinah
J
Kim
Phuong
P
Khuu
D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism; D002648:Child; D005909:Glioblastoma / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000378:metabolism; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000378:metabolism; D018296:Pilomatrixoma / Q000209:etiology* / Q000378:metabolism; D011379:Prognosis; D051176:beta Catenin / Q000378:metabolism
D051176:beta Catenin