Novel substituted 9-norbornylpurines and their activities against RNA viruses.
We report on the synthesis and the study of the structure-activity relationship of novel 9-norbornyl-6-chloropurine derivatives, which exert selective antiviral activity on the replication of Coxsackievirus B3. In particular, the synthetic approaches towards norbornyl derivatives bearing diverse side chains were studied. The main goal of the study was to determine the influence of the norbornane moiety substitution at positions 5' and 6' on selective antiviral activity with special regard to the liphophilicity profile of the substituent.
Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Michal
M
Sála
Hubert
H
Hřebabecký
Pieter
P
Leyssen
Milan
M
Dejmek
Martin
M
Dračínský
Armando M
AM
De Palma
Johan
J
Neyts
Radim
R
Nencka
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003384:Coxsackievirus Infections / Q000188:drug therapy; D029822:Enterovirus B, Human / Q000187:drug effects*; D006801:Humans; D009636:Norbornanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014709:Vero Cells
D000998:Antiviral Agents; D009636:Norbornanes; D011687:Purines; C079308:6-chloropurine