Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma: a study of 1066 patients.
BACKGROUND
The surgical management of papillary thyroid microcarcinoma (PTMC), especially regarding the necessity of central lymph node dissection, remains controversial.


OBJECTIVE
The objective of the study was to describe the clinicopathological features of PTMC and to identify the risk factors for central lymph node metastasis (CLNM) that can guide surgical strategies for patients with PTMC.


METHODS
In this retrospective cross-sectional study, risk factors and outcome variables were assessed at the time of surgery for the primary tumor.


METHODS
The study was conducted at a university-based tertiary care cancer hospital.


METHODS
Data from the medical records of 1066 consecutive patients diagnosed with PTMC over a 5-yr period were analyzed.


RESULTS
Our multivariate logistic regression analysis found male gender, younger age (≤45 yr of age), multifocal lesions, extrathyroidal extension, and larger size of the primary tumor (>6 mm) to be associated with CLNM; multifocal lesions were associated with the highest risk (odds ratio 4.476, 95% confidence interval 2.975-6.735). Extrathyroidal extension, multifocal lesions, and CLNM were associated with lateral neck lymph node metastasis (LLNM). In patients with a solitary primary tumor, tumor location in the upper third of the thyroid lobe was associated with a lower risk of CLNM and a higher risk of LLNM.


CONCLUSIONS
Prophylactic central lymph node dissection need be considered in PTMC patients presenting with risk factors. In PTMC patients with a solitary primary tumor, tumor location can assist in the evaluation of LLNM. We recommend multicenter research and long-term follow-up to better understand the risk factors and surgical management of PTMC.
Department of Head and Neck Surgery, Fudan University Cancer Hospital, Department of Oncology, Shanghai Medical College, 270 Dong An Road, Shanghai 200032, People's Republic of China.
Ling
L
Zhang
Wen-Jun
WJ
Wei
Qing-Hai
QH
Ji
Yong-Xue
YX
Zhu
Zhuo-Ying
ZY
Wang
Yu
Y
Wang
Cai-Ping
CP
Huang
Qiang
Q
Shen
Duan-Shu
DS
Li
Yi
Y
Wu
D000328:Adult; D000367:Age Factors; D002277:Carcinoma; D002291:Carcinoma, Papillary / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D057286:Electronic Health Records; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary*; D006785:Hospitals, University; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D016606:Thyroid Nodule / Q000473:pathology* / Q000601:surgery; D047368:Tumor Burden