Coffee component 3-caffeoylquinic acid increases antioxidant capacity but not polyphenol content in experimental cerebral infarction.
Although coffee has antioxidant capacity, it is not known which of its bioactive compounds is responsible for it, nor has it been analyzed in experimental cerebral infarction. We studied the effect one of its compounds, 3-caffeoylquinic acid (3-CQA), at doses of 4, 25 and 100 μg on plasma antioxidant capacity and plasma polyphenol content, measuring the differences before and after inducing a cerebral infarction in an experimental rat model. We compared them with 3-caffeoylquinic-free controls. The increase in total antioxidant capacity was only higher than in controls in 3-CQA treated animals with the highest dose. This increase in antioxidant capacity was not due to an increase in polyphenols. No differences between the experimental and control group were found regarding polyphenol content and cerebral infarction volume. In conclusion, this increase in antioxidant capacity in the group that received the highest dose of 3-CQA was not able to reduce experimental cerebral infarction.
Unidad de Investigación, Hospital General Yagüe, Burgos, Spain. ruizcresposilvia@hotmail.com
Silvia
S
Ruiz-Crespo
Jose M
JM
Trejo-Gabriel-Galan
Monica
M
Cavia-Saiz
Pilar
P
Muñiz
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003069:Coffee / Q000737:chemistry*; D008297:Male; D059808:Polyphenols / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D003069:Coffee; D059808:Polyphenols; D002726:Chlorogenic Acid