[Perspectives of prevention and treatment of herpes symplex with regular recurrence].
OBJECTIVE
To assess efficacy of two-stage treatment of severe genital herpes (GH) with regular recurrences: combined use of antivirus medicines with interferon preparations and its inductors followed by antirecurrence vaccine therapy.


METHODS
Two-stage treatment was given to 100 patients suffering from GH with severe regular recurrences. One-stage treatment included famvir in combination with interferon (viferon) or interferon inductors (amixin, cycloferon) and antioxidants. Stage two treatment consisted of vaccine therapy of patients who failed prophylactic standard vaccination by allergometric technique.


RESULTS
The first stage treatment prolonged recurrence-free period 2-3-fold in more than 85% patients, improved quality of life. Stage-two treatment resulted in long-term clinicoimmunological remission which is necessary for conduction of anti-recurrence vaccine treatment.


CONCLUSIONS
Changes in therapeutic-preventive policy in patients with recurrent GH with regular recurrence (2 stage of treatment) prolong recurrence-free intervals, improve quality of life and social adaptation of patients.
V A
VA
Isakov
D K
DK
Ermolenko
D V
DV
Isakov
D000166:Acridines / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000517:prevention & control; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage*; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D011788:Quality of Life; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods; D055502:Secondary Prevention; D012720:Severity of Illness Index; D013994:Tilorone / Q000627:therapeutic use
D000166:Acridines; D000975:Antioxidants; D000998:Antiviral Agents; D022301:Herpes Simplex Virus Vaccines; D007369:Interferon Inducers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013994:Tilorone; C026430:10-carboxymethyl-9-acridanone