Construction of highly functional α-amino nitriles via a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams.
The first tertiary amine-catalyzed multicomponent tandem Strecker-allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams.
Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Feng
F
Pan
Jian-Ming
JM
Chen
Zhe
Z
Zhuang
Yin-Zhi
YZ
Fang
Sean Xiao-An
SX
Zhang
Wei-Wei
WW
Liao
D000478:Alkylation; D000586:Amination; D002384:Catalysis; D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
D007769:Lactams; D009570:Nitriles