Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype.
Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues.
Center for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA. tsukit@med.hokudai.ac.jp
Tadasuke
T
Tsukiyama
Terry P
TP
Yamaguchi
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development; D051379:Mice; D018345:Mice, Knockout; D009830:Olfactory Bulb / Q000033:anatomy & histology / Q000254:growth & development*; D010641:Phenotype; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*
D051153:Wnt Proteins; C492031:Wnt2b protein, mouse