Medullary thyroid nodules by measurement of calcitonin (Ct) in aspiration needle washout in patients with multinodular goiter and moderately elevated serum Ct.
The accuracy of fine needle aspiration cytology (FNAC) is low in medullary thyroid carcinomas (MTC). Recently, a few papers analyzed the measurement of calcitonin (Ct) in washout of the needle after aspiration (WO-Ct) suggesting that this approach may be useful in patients with high serum Ct. Here we reported, for the first time in our best knowledge, 3 patients with multinodular goiter, moderately elevated serum Ct, high value of WO-Ct, and medullary outcome. These findings suggest that in presence of high serum Ct, FNAC should be performed in all nodules, and it should be combined with WO-Ct in all cases.
Section of Endocrinology and Diabetology, Ospedale Israelitico, Rome, Italy. pierpaolo.trimboli@gmail.com
P
P
Trimboli
G
G
Nigri
F
F
Romanelli
D D
DD
Cicciarella Modica
A
A
Crescenzi
S
S
Valabrega
L
L
Giovanella
D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods; D002116:Calcitonin / Q000032:analysis* / Q000097:blood*; D018278:Carcinoma, Neuroendocrine; D003937:Diagnosis, Differential; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D006044:Goiter, Nodular / Q000097:blood* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D016606:Thyroid Nodule / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
D002116:Calcitonin