Serological and molecular tools to detect neurologic parasitic zoonoses in rural Cameroon.
Parasitic helminthiases, such as toxocariasis, cysticercosis and paragonimiasis are a public health threat, since they can affect the brain leading to neurological disorders. Epilepsy and paragonimiasis are common in southwestern Cameroon. We reviewed the literature for studies using antigens to diagnose toxocariasis, cysticercosis, and paragonimiasis. Serology revealed that 61 (36.3%), 26 (15.5%) and 2 (1.2%) of 168 persons examined [78 males (15.2 +/- 8.2 years old), 90 females (12.9 +/- 5.9 years old), 143 persons < 20 years old] had antibody responses to toxocariasis, paragonimiasis and cysticercosis, respectively. Of the 14 people with epilepsy, 5 were seropositive for Toxocara antigens and 1 was positive for both Toxocara and Paragonimus antigens. Two children were serologically confirmed to have cysticercosis. Serologic screening for cysticercosis may be feasible to detect asymptomatic cysticercosis in children in endemic areas leading to early treatment. The causative Paragonimus species was confirmed to be P. africanus by molecular sequencing. Education, screening and confirmation test for these diseases may be needed for control in Cameroon.
Department of Parasitology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan. ankouawa@yahoo.fr
Agathe
A
Nkouawa
Yasuhito
Y
Sako
Roger
R
Moyou-Somo
Akira
A
Ito
D000293:Adolescent; D000818:Animals; D002163:Cameroon / Q000453:epidemiology; D002648:Child; D003551:Cysticercosis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D010237:Paragonimiasis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D016133:Polymerase Chain Reaction; D012424:Rural Population; D012698:Serologic Tests; D013622:Taeniasis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D014120:Toxocariasis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult; D015047:Zoonoses / Q000453:epidemiology