Peripheral pulsed electromagnetic fields may reduce the placebo effect in migraine patients that do not respond to the sham intervention in a randomized, placebo-controlled, double-blind, cross-over clinical trial.
OBJECTIVE
The purpose of the study was to evaluate the effect of the pulsed electromagnetic fields (PEMF) and its possible modulation of the placebo effect in migraine.


METHODS
Placebo-controlled, randomized, double-blind, cross-over clinical trial.


METHODS
Government third level hospital.


METHODS
Patients with migraine were included. PEMF were applied to the wrist with a bracelet.


METHODS
Frequency and intensity of the migraine attacks at baseline and during treatment were recorded. Also, we valuated the possible influence of gender and the presence of aura in the PEMF and placebo responses.


RESULTS
Eighteen patients (fifteen women, 30±2 years old) were included. Migraine frequency and intensity was reduced with both PEMF and placebo to a similar extent in the whole population. However, in responders to placebo, migraine intensity was reduced to a median of 100% with the placebo and to 60% with the PEMF, while in non-responders there was only a slight effect of both treatments. Our results do not suggest an influence of gender or presence of aura in the outcomes.


CONCLUSIONS
Treatment with PEMF may not alter either migraine intensity or frequency compared to baseline, but may reduce the response to placebo in migraine patients.
Department of Neurophysiology, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, Tlalpan, Mexico City 14269, Mexico. pegaso31@yahoo.com
Daniel
D
San-Juan
Ana Aurora L
AA
Pon
Fernando Z
FZ
Pohls
Juan de Dios
Jde D
Del Castillo-Calcáneo
Iván
I
Pérez-Neri
Camilo
C
Ríos
D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004574:Electromagnetic Fields; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000628:therapy*; D015990:Placebo Effect; D010919:Placebos; D012720:Severity of Illness Index; D055815:Young Adult
D010919:Placebos