Comparison of contrast media and low-molecular-weight dextran for frequency-domain optical coherence tomography.
BACKGROUND
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may lead to the impairment of renal function. The safety and usefulness of the non-occlusion method with low-molecular-weight dextran L (LMD-L) via a guiding catheter for TD-OCT image acquisition have been reported previously. The aim of the present study was to compare the image quality and quantitative measurements between contrast media and LMD-L for FD-OCT image acquisition in coronary stented lesions.


RESULTS
Twenty-two patients with 25 coronary stented lesions were enrolled in this study. FD-OCT was performed with the continuous-flushing method via a guiding catheter. Both contrast media and LMD-L were infused at a rate of 4 ml/s by an autoinjector. With regard to image quality, the prevalence of clear image segments was comparable between contrast media and LMD-L (97.9% vs. 96.5%, P=0.90). Furthermore, excellent correlations were observed between both flushing solutions in terms of minimum lumen area, mean lumen area, and mean stent area. The total volumes of contrast media and of LMD-L needed for OCT image acquisition were similar.


CONCLUSIONS
FD-OCT image acquisition with LMD-L has the potential to reduce the total amount of contrast media without loss of image quality.
Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
Yuichi
Y
Ozaki
Hironori
H
Kitabata
Hiroto
H
Tsujioka
Seiki
S
Hosokawa
Manabu
M
Kashiwagi
Kohei
K
Ishibashi
Kenichi
K
Komukai
Takashi
T
Tanimoto
Yasushi
Y
Ino
Shigeho
S
Takarada
Takashi
T
Kubo
Keizo
K
Kimura
Atsushi
A
Tanaka
Kumiko
K
Hirata
Masato
M
Mizukoshi
Toshio
T
Imanishi
Takashi
T
Akasaka
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D006328:Cardiac Catheterization; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology*; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects; D007564:Japan; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011237:Predictive Value of Tests; D015607:Stents; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome
D003287:Contrast Media; D003911:Dextrans; D007472:Iohexol