A "one-pot" multicomponent approach to polysubstituted 4-aminopyridines.
A novel and facile domino reaction has been developed to synthesize a variety of polysubstituted 4-aminopyridines from α-azidovinylketones, aldehydes and methylamine derivatives in reasonably good yields under mild conditions. Additionally, a possible mechanism is proposed.
Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Jiaan
J
Shao
Wanwan
W
Yu
Zhanying
Z
Shao
Yongping
Y
Yu
D015761:4-Aminopyridine / Q000138:chemical synthesis / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry; D008744:Methylamines / Q000737:chemistry; D008968:Molecular Conformation
D000447:Aldehydes; D007659:Ketones; D008744:Methylamines; D015761:4-Aminopyridine; C027451:methylamine