[Association between HLA-Cw polymorphism and inflammatory bowel disease].
OBJECTIVE
To investigate the association of HLA-Cw alleles with inflammatory bowel disease(IBD), so as to identify IBD susceptibility gene.


METHODS
The HLA-Cw genotype were analyzed in 100 patients with ulcerative colitis (UC), 73 patients with Crohn's disease (CD) and 106 randomly ethnically matched healthy controls by sequence specific primer polymerase chain (PCR-SSP).


RESULTS
HLA-Cw*07 gene phenotype frequencies increased in patients with UC (0.430) compared with that in healthy controls (0.226), P = 0.002; while HLA-Cw*12 gene phenotype frequencies increased in patients with CD (0.356) compared with that in healthy controls (0.123), P = 0.000.


CONCLUSIONS
HLA-Cw*07 allele and HLA-Cw*12 allele may be strongly associated with the susceptibility of UC and CD, respectively.
Department of Gastroenterology, Tongji University, Shanghai, China.
Hui-xia
HX
Zhang
Ji-chang
JC
Li
Gang
G
Xu
Zhan-ju
ZJ
Liu
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D055815:Young Adult
D015236:HLA-C Antigens