[Distribution of HLA specificity frequencies in patients with cystic echinococcosis].
This investigation was undertaken to study the associations of the polymorphic variants of the HLA-DRBI and HLA-DQB1 loci with the development of cystic echinococcosis in children. The material for the investigation was collected from 57 children admitted for surgery to the clinic of the Department of Pediatric Surgery, Orthopedics, and Anesthesiology, Bashkir State Medical University (Ufa). The PROTRANS kit (Germany) was used to isolate DNA samples from peripheral venous blood served as an object of the investigations. HLA specificities were typed by polymerase chain reaction. Molecular genetic studies established the association of DRB1*07, DQB1*0.9, DQB1*02 specificities with the increased risk of cystic echinococcosis in children. The echinococcosis cyst suppuration-complicated course of the disease was found to be more frequently encountered in DQB1*02 and DRB1*03 allele carriers.
G I
GI
Lukmanova
A A
AA
Gumerov
Z M
ZM
Elicheva
L I
LI
Lukmanova
D000483:Alleles; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics / Q000276:immunology; D001486:Bashkiria; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003560:Cysts; D004443:Echinococcosis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D004446:Echinococcus / Q000276:immunology*; D000939:Epitopes / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D059866:HLA-DQ beta-Chains / Q000097:blood / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D016133:Polymerase Chain Reaction; D013492:Suppuration
D000939:Epitopes; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains