A computational model for previtamin D(3) production in skin.
Low levels of vitamin D have been implicated in a wide variety of health issues from calcemic diseases to cancer, diabetes and cardiovascular disease. For most humans, the majority of vitamin D(3) is derived from sunlight. How much vitamin D is produced under given exposure conditions is still widely discussed. We present a computational model for the production of (pre-)vitamin D within the skin. It accounts for spectral irradiance, optical properties of the skin and concentration profile of provitamin D. Results are computed for various sets of these parameters yielding the distribution of produced previtamin D in the skin.
HOT-Hanover Center for Optical Technologies, Leibniz Universität Hannover, Nienburger Str. 17, 30167 Hannover, Germany. merve.wollweber@hot.uni-hannover.de
Merve
M
Meinhardt-Wollweber
Ronald
R
Krebs
D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry; D006801:Humans; D008962:Models, Theoretical; D012867:Skin / Q000528:radiation effects*; D013056:Spectrophotometry, Ultraviolet; D013472:Sunlight
D002762:Cholecalciferol; C025168:previtamin D(3)