Iron(II)-catalyzed enantioselective meso-epoxide-opening with anilines.
A highly enantioselective method for the catalytic opening of aromatic meso-epoxides with aniline derivatives was developed. The desired chiral β-amino alcohols were obtained in mostly good to very good yields with excellent enantioselectivities. Structural evidence of the pre-catalyst revealed a scarcely disclosed heptadentate Fe(II) complex with the chiral bipyridine ligand.
Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec (Québec) G1V 0A6, Canada.
Baptiste
B
Plancq
Thierry
T
Ollevier