Identification of a degradation intermediate of the momilactone A rice phytoalexin by the rice blast fungus.
We have already shown that major rice diterpene phytoalexin, momilactone A, was detoxified by Magnaporthe oryzae. We report here the identification by NMR, MS, and chemical synthesis of 3,6-dioxo-19-nor-9β-pimara-7,15-diene (1) as the degradation intermediate. Compound 1 exhibited similar antifungal activity to that of momilactone A, indicating 1 to be a precursor of possible detoxified compounds.
College of Agriculture, Ibaraki University, Ami, Ibaraki, Japan.
Takuya
T
Imai
Yuko
Y
Ohashi
Ichiro
I
Mitsuhara
Shigemi
S
Seo
Hiroaki
H
Toshima
Morifumi
M
Hasegawa
D000935:Antifungal Agents / Q000378:metabolism; D004224:Diterpenes / Q000378:metabolism*; D020082:Magnaporthe / Q000378:metabolism* / Q000472:pathogenicity / Q000502:physiology; D012275:Oryza / Q000276:immunology*; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology*; D012717:Sesquiterpenes / Q000378:metabolism*; D013057:Spectrum Analysis; D000094162:Phytoalexins
D000935:Antifungal Agents; D004224:Diterpenes; D012717:Sesquiterpenes; C116023:momilactone A; D000094162:Phytoalexins