Asymmetric homogeneous hydrogenations at scale.
Asymmetric hydrogenations are increasingly being used to introduce stereogenic centres into products used in the life sciences industries. There are a number of potential pitfalls when moving from a laboratory reaction to a manufacturing process, not least of which is safety. Time-to-market pressure leads to short development times, which in the past could be a large barrier for the implementation of catalytic steps; now there are new ways to minimise this problem. The potential problems associated with impurities and other methods that can shut down the hydrogenation reactions are highlighted in this critical review (353 references).
DSM Innovative Synthesis BV, PMB 150, 9650 Strickland Road Suite 103, Raleigh, North Carolina 27615, USA. david.ager@dsm.com
David J
DJ
Ager
André H M
AH
de Vries
Johannes G
JG
de Vries
D002384:Catalysis; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006865:Hydrogenation; D007221:Industry; D009930:Organic Chemicals / Q000737:chemistry; D012449:Safety
D009930:Organic Chemicals