Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries.
Combinatorial libraries of peptoids (oligo-N-substituted glycines) have proven to be useful sources of protein ligands. Each unit of the peptoid oligomer is derived from 2-haloacetic acid and a primary amine. To increase the chemical diversity available in peptoid libraries, we demonstrate here that heterocyclic halomethyl carboxylic acids can be employed as backbone building blocks in the synthesis of peptoid-based oligomers. Optimized conditions are reported that allow the creation of large, high quality combinatorial libraries containing these units.
Department of Chemistry, The Scripps Research Institute, Scripps Florida , Jupiter, Florida 33458, United States.
Animesh
A
Aditya
Thomas
T
Kodadek
D001393:Azoles / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D019151:Peptide Library; D034444:Peptoids / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001393:Azoles; D006571:Heterocyclic Compounds; D019151:Peptide Library; D034444:Peptoids