Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil.
Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed that C. officinalis presented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.
Laboratory of Natural Products, Pharmacy Faculty, Federal University of Goiás, 74605-220 Goiânia, GO, Brazil.
Leila Maria Leal
LM
Parente
Ruy de Souza
Rde S
Lino Júnior
Leonice Manrique Faustino
LM
Tresvenzol
Marina Clare
MC
Vinaud
José Realino
JR
de Paula
Neusa Margarida
NM
Paulo