Kinetic model of HIV infection including hematopoietic progenitor cells.
Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4⁺ T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4⁺ T cells the infection starts rapidly again after the therapy.
Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden. zhdanov@catalysis.ru
Vladimir P
VP
Zhdanov
D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000821:virology; D006801:Humans; D007700:Kinetics; D018448:Models, Immunological; D009716:Numerical Analysis, Computer-Assisted; D014766:Viremia / Q000276:immunology; D017735:Virus Latency / Q000276:immunology