Clinical decision support to promote safe prescribing to women of reproductive age: a cluster-randomized trial.
BACKGROUND
Potentially teratogenic medications are frequently prescribed without provision of contraceptive counseling.


OBJECTIVE
To evaluate whether computerized clinical decision support (CDS) can increase primary care providers' (PCPs') provision of family planning services when prescribing potentially teratogenic medications.


METHODS
Cluster-randomized trial conducted in one academic and one community-based practice between October of 2008 and April of 2010.


METHODS
Forty-one PCPs were randomized to receive one of two types of CDS which alerted them to risks of medication-induced birth defects when ordering potentially teratogenic medications for women who may become pregnant. The 'simple' CDS provided a cautionary alert; the 'multifaceted' CDS provided tailored information and links to a structured order set designed to facilitate safe prescribing. Both CDS systems alerted PCPs about medication risk only once per encounter.


METHODS
We assessed change in documented provision of family planning services using data from 35,110 encounters and mixed-effects models. PCPs completed surveys before and after the CDS systems were implemented, allowing assessment of change in PCP-reported counseling about the risks of medication-induced birth defects and contraception.


RESULTS
Both CDS systems were associated with slight increases in provision of family planning services when potential teratogens were prescribed, without a significant difference in improvement by CDS complexity (p = 0.87). Because CDS was not repeated, 13% of the times that PCPs received CDS they substituted another potential teratogen. PCPs reported significant improvements in several counseling and prescribing practices. The multifaceted group reported a greater increase in the number of times per month they discussed the risks of medication use during pregnancy (multifaceted: +4.9 ± 7.0 vs. simple: +0.8 ± 3.2, p = 0.03). The simple CDS system was associated with greater clinician satisfaction.


CONCLUSIONS
CDS systems hold promise for increasing provision of family planning services when fertile women are prescribed potentially teratogenic medications, but further refinement of these systems is needed.
Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Schwarzeb@upmc.edu
Eleanor Bimla
EB
Schwarz
Sara M
SM
Parisi
Steven M
SM
Handler
Gideon
G
Koren
Elan D
ED
Cohen
Grant J
GJ
Shevchik
Gary S
GS
Fischer
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D003376:Counseling / Q000592:standards; D020000:Decision Support Systems, Clinical; D011307:Drug Prescriptions / Q000592:standards*; D005193:Family Planning Services / Q000592:standards / Q000600:supply & distribution; D005260:Female; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010353:Patient Education as Topic / Q000592:standards; D010414:Pennsylvania; D010817:Physician-Patient Relations; D016742:Preconception Care / Q000592:standards; D011320:Primary Health Care / Q000592:standards; D043762:Reproductive Behavior / Q000706:statistics & numerical data*; D013723:Teratogens; D055815:Young Adult
D013723:Teratogens