Gold nanoparticle based signal enhancement liquid crystal biosensors for DNA hybridization assays.
A novel signal enhanced liquid crystal biosensor based on using AuNPs for highly sensitive DNA detection has been developed. This biosensor not only significantly decreases the detection limit, but also offers a simple detection process and shows a good selectivity to distinguish perfectly matched target DNA from two-base mismatched DNA.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Shengyuan
S
Yang
Yanmei
Y
Liu
Hui
H
Tan
Chao
C
Wu
Zhaoyang
Z
Wu
Guoli
G
Shen
Ruqin
R
Yu
D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D011437:Propylamines; D012821:Silanes / Q000737:chemistry
D011437:Propylamines; D012821:Silanes; D006046:Gold; D004247:DNA; C477625:amino-propyl-triethoxysilane