Ghrelin, appetite and critical illness.
OBJECTIVE
Recovery and rehabilitation after critical illness is a vital part of intensive care management. The role of feeding and nutritional intervention is the subject of many recent studies. The gastric hormone ghrelin has effects on appetite and food intake and on immunomodulatory functions. Here we review the interactions between critical illness, appetite regulation, nutrition and ghrelin.


RESULTS
Critical illness results in significant loss of lean body mass; strategies to prevent this have so far proven unsuccessful. Ghrelin has been shown to reduce catabolic protein loss in animal models of critical illness and improve body composition in chronic cachectic illnesses in humans.


CONCLUSIONS
Enhancing recovery from critical illness will improve both short-term and long-term outcomes. Ghrelin may offer an important means of improving appetite, muscle mass and rehabilitation in the period after critical illness, although studies are needed to see whether this potential is realized.
Section of Investigative Medicine, Imperial College London, London, UK.
Neil E
NE
Hill
Kevin G
KG
Murphy
Mervyn
M
Singer
D000818:Animals; D001066:Appetite; D001069:Appetite Regulation; D016638:Critical Illness; D002149:Energy Intake; D054439:Ghrelin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018529:Nutritional Support / Q000379:methods*
D054439:Ghrelin