Non-lytic expulsion/exocytosis of Candida albicans from macrophages.
Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.
Immunology and Infection, School of Medicine and Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Judith M
JM
Bain
Leanne E
LE
Lewis
Blessing
B
Okai
Janet
J
Quinn
Neil A R
NA
Gow
Lars-Peter
LP
Erwig
D002176:Candida albicans / Q000254:growth & development / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000382:microbiology; D005089:Exocytosis; D006801:Humans; D025301:Hyphae / Q000254:growth & development / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D010587:Phagocytosis