An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice.
Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.
University of Würzburg, Department of Neurology, Würzburg, Germany. Albert_C2@klinik.uni-wuerzburg.de.
Christiane
C
Albert-Weißenberger
Csanád
C
Várrallyay
Furat
F
Raslan
Christoph
C
Kleinschnitz
Anna-Leena
AL
Sirén