Redox chemistry of green tea polyphenols: therapeutic benefits in neurodegenerative diseases.
Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].
Health Innovations Research Institute & School of Applied Sciences, RMIT University, School Applied Sciences, Building 3, Bowen Street Melbourne VIC 3001, Australia. helmut.hugel@rmit.edu.au
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Hügel
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D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D028241:Camellia sinensis / Q000737:chemistry*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D018696:Neuroprotective Agents; D059808:Polyphenols