Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection.
CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.
Imperial College, London, UK. e.hamlyn@nhs.net
Elizabeth
E
Hamlyn
Stephen
S
Hickling
Kholoud
K
Porter
John
J
Frater
Rodney
R
Phillips
Mark
M
Robinson
Nicola E
NE
Mackie
Steve
S
Kaye
Myra
M
McClure
Sarah
S
Fidler
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D019713:Receptors, CCR5 / Q000276:immunology; D019718:Receptors, CXCR4 / Q000276:immunology* / Q000502:physiology
D015415:Biomarkers; C527276:CXCR4 protein, human; D019713:Receptors, CCR5; D019718:Receptors, CXCR4