[Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion].
OBJECTIVE
To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion.


METHODS
Eighteen healthy pigs were randomly divided into 3 groups: resveratrol group, nitroglycerin group and control group. Animal model of acute coronary occlusion was established through PTCA method, and the blood flow spectrum in the left circumflex artery (LCX) was detected using intracoronary Doppler ultrasound.


RESULTS
The average peak velocity (APV) in infarction correlation artery (IRA) was significantly decreased immediately after coronary occlusion [(0.85 ± 0.25) cm/s vs. (24.83 ± 3.43) cm/s, P < 0.05]. The APV remained unchanged during 0, 30 and 60 minutes after the occlusion. Reversed or bidirectional blood flow was observed and the APV increased significantly [(9.22 ± 0.80) cm/s vs. (0.84 ± 0.21) cm/s, (8.93 ± 1.28) cm/s vs. (0.86 ± 0.26) cm/s respectively, P < 0.05] after the coronary injection of resveratrol (2 mg) or nitroglycerin (0.3 mg). There was no significant difference in peak APV between the resveratrol and nitroglycerin groups. The duration of increased APV was significantly longer in resveratrol group than that in nitroglycerin group [(58.83 ± 6.15) min vs. (21.80 ± 5.79) min, P < 0.05].


CONCLUSIONS
The collateral circulation after acute coronary occlusion was obviously insufficient in pigs. Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model.
Department of Cardiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China. xzzrw@163.com
Zhi-rong
ZR
Wang
Wu
W
Xu
Chao-qun
CQ
Zhang
Wei
W
Xie
Zhao-feng
ZF
Zhou
Xiao-feng
XF
Zhou
Zhuo-qi
ZQ
Zhang
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003097:Collateral Circulation; D003326:Coronary Circulation / Q000187:drug effects; D054059:Coronary Occlusion / Q000188:drug therapy*; D003331:Coronary Vessels; D004195:Disease Models, Animal; D006321:Heart; D006439:Hemodynamics; D005996:Nitroglycerin; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013552:Swine
D000975:Antioxidants; D013267:Stilbenes; D005996:Nitroglycerin; D000077185:Resveratrol