Insulin resistance but not impaired β-cell function: a key feature in Chinese normal-weight PCOS women with normal glucose regulation.
OBJECTIVE
To evaluate insulin sensitivity and β-cell function in Chinese polycystic ovary syndrome (PCOS) women while taking into account the confounding variables including body mass index (BMI), blood glucose levels, ethnicity, medication history and a family history of type 2 diabetes.


METHODS
Cross-sectional analysis.


METHODS
Clinical research center in China.


METHODS
76 PCOS women and 20 age-matched healthy control women.


METHODS
No.


METHODS
All subjects underwent botnia euglycemic-hyperinsulinemic clamp to assess their insulin sensitivity expressed as M value and β-cell function expressed as deposition index (DI).


RESULTS
Compared with age-matched controls, both DI and M (p < 0.05, respectively) value were lower in PCOS group with normal glucose regulation (NGR), and they (p < 0.05, respectively) were the lowest in PCOS group with impaired glucose regulation (IGR). The subgroup analysis showed that compared with normal-weight controls, DI (p = 0.072) was similar but M value (p < 0.05) was lower in normal-weight PCOS group with NGR, and DI (p < 0.05) and M value (p < 0.05) were lower in overweight PCOS group with NGR. DI and M value (p < 0.05, respectively) of overweight PCOS group with IGR were the lowest among all groups.


CONCLUSIONS
There was insulin resistance but not impaired β-cell function in Chinese normal-weight PCOS women with NGR. Insulin resistance may be an intrinsic factor prior to impaired β-cell function of PCOS.
Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Weiping
W
Li
Ling
L
Ma
Qifu
Q
Li
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D015309:Glucose Clamp Technique; D018149:Glucose Intolerance / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D050177:Overweight / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D055815:Young Adult
D001786:Blood Glucose