[Dependence of IgG titers specific to various hepatitis C virus proteins on features of chronic infection course].
OBJECTIVE
Analysis of IgG titers that are specific to various hepatitis C proteins depending on features of chronic infection course.


METHODS
Qualitative analysis of levels of IgG specific to a number of hepatitis C virus proteins was performed in 30 patients and 30 virus carriers.


RESULTS
Significant differences between these HCV infection course variants by level of accumulation of all studied HCV antibody groups were detected. Low a-core and a-NS4 IgG, high a-NS3 and medium a-NS5 titers may be an indicator of HCV carriage. Medium and high a-core, medium a-NS3 and a-NS4 as well as higher a-NS5 titers indicate chronic hepatitis C.


CONCLUSIONS
The proposed method can be used for screening of chronic HCV infection course in the clinical practice.
D M
DM
Poponin
É S
ÉS
Gorovits
A L
AL
Bondarenko
D000328:Adult; D002353:Carrier State; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D018937:Hepatitis C Antibodies / Q000032:analysis / Q000276:immunology*; D018936:Hepatitis C Antigens / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007118:Immunoassay; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000276:immunology; D012107:Research Design; D014758:Viral Core Proteins / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000032:analysis / Q000276:immunology; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; D012324:RNA-Dependent RNA Polymerase
D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D007074:Immunoglobulin G; D012367:RNA, Viral; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C093542:NS4 protein, hepatitis C virus; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase