Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.
A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection-double cyclization sequence.
CNRS UMR COBRA, INSA et Université de Rouen, FR 3038, Institut de Recherche en Chimie Organique Fine, Mont Saint-Aignan, France. vincent.gembus@insa-rouen.fr
Vincent
V
Gembus
Solenn
S
Janvier
Jean-Pierre
JP
Lecouvé
Lucile
L
Vaysse-Ludot
Jean-François
JF
Brière
Vincent
V
Levacher
D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D057786:Peptidomimetics; D011719:Pyrazines