Sudden death caused by aortic dissection in a patient with polycystic kidney disease.
A 43-year-old man presented at the emergency medical unit with chest pain. The results of a clinical examination were normal, apart from sternum pain (without radiation) on palpation. The patient had no respiratory problems and the pain was relieved by paracetamol. The electrocardiogram, laboratory tests and chest X-ray were normal. However, the man was found dead the next morning. In the autopsy, we noted the presence of haemopericardium, aortic dissection (starting from the vessel's origin and extended to the aortic arch and on through the diaphragm), polycystic kidney disease and liver cysts. In adult autosomal dominant polycystic kidney disease (ADPKD) patients, the main causes of death are ruptured intracerebral aneurysms, coronary artery disease, congestive heart failure, valvular heart disease and ruptured abdominal aortic aneurysms. Aortic dissection is considered to be rare cause of sudden death in ADPKD sufferers. ADPKD can have serious consequences for the vascular system. The families of confirmed ADPKD sufferers must be informed and screened as early as possible, in order to prevent renal and cardiovascular complications.
Forensic Unit, Amiens University Medical Centre, Amiens, France. gignon.maxime@chu-amiens.fr
M
M
Gignon
C
C
Defouilloy
D
D
Montpellier
D
D
Chatelain
S
S
Traulle
C
C
Ammirati
O
O
Jarde
C
C
Manaouil
D000328:Adult; D000784:Aortic Dissection / Q000235:genetics* / Q000473:pathology*; D017545:Aortic Aneurysm, Thoracic / Q000235:genetics* / Q000473:pathology*; D002885:Chromosomes, Human, Pair 16; D003560:Cysts / Q000235:genetics / Q000523:psychology; D003645:Death, Sudden / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology; D008297:Male; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging