Synthesis of 2,4,6-trichlorophenyl hydrazones and their inhibitory potential against glycation of protein.
2,4,6-Trichlorophenyl hydrazones 1-35 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 14 (IC50 = 27.2 ± 0.00 μM), and 18 (IC50 = 55.7 ± 0.00 μM) showed an excellent activity against glycation of protein, better than the standard (rutin, IC50 = 70 ± 0.50 μM). This study thus identified a novel series of antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. khalid.khan@iccs.edu
Khalid Mohammed
KM
Khan
Zarbad
Z
Shah
Viqar Uddin
VU
Ahmad
Momin
M
Khan
Muhammad
M
Taha
Fazal
F
Rahim
Humera
H
Jahan
Shahnaz
S
Perveen
M Iqbal
MI
Choudhary
D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006835:Hydrazones; D012709:Serum Albumin