[Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema].
There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we believe that more human translational studies are necessaries, otherwise the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this disease. Currently, stem cell therapy is still to be considered as an area of active research, lacking a strong rationale for performing clinical trials in COPD. Although stem cells would be likely to represent a heterogeneous population of cells, the different cell subsets and their importance in the pathogenesis of the different clinical phenotypes need to be fully characterised before progressing to clinical trials. Moreover, the potential side effects of the stem cell therapy are often underestimated. We should not ignore that some of the most deadly neoplasms are arising from stem cells.
Dipartimento di Medicina, Universita di Ferrara, Italy. gaetano.caramori@unife.it
Gaetano
G
Caramori
Paolo
P
Casolari
Elvira
E
Garofano
Federico
F
Mazzoni
Irene
I
Marchi
Marco
M
Contoli
Alberto
A
Papi
D000818:Animals; D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007558:Italy; D045164:Mesenchymal Stem Cell Transplantation; D015337:Multicenter Studies as Topic; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000941:ethics / Q000639:trends; D013234:Stem Cells; D016896:Treatment Outcome