A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease.
BACKGROUND
CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP4A11 gene and coronary artery disease (CAD).


METHODS
A total of 361 patients with CAD and 315 controls were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs4660980, rs3890011, and rs1126742). The data were assessed for 3 groups: total participants, men, and women via case-control studies.


RESULTS
For total participants and men, the distribution of SNP3 (rs3890011) genotypes showed a significant difference between CAD and control participants (P = .030 and P = .013, respectively), the distribution of the recessive model of SNP3 (GG vs CC + GC) was significantly higher in CAD patients than in control participants (P = .011 and P = .014, respectively), the significant difference was retained after adjustment for covariates (for total participants, 95% confidence interval [CI]: 1.137-2.423, P = .009; and for males, 95% CI: 1.173-3.013, P = .009).


CONCLUSIONS
rs3890011 maybe a novel polymorphism of the CYP4A11 gene associated with CAD in a Han Chinese population.
Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Zhenyan
Z
Fu
Yitong
Y
Ma
Xiang
X
Xie
Ding
D
Huang
Hong
H
Yang
Tomohiro
T
Nakayama
Naoyuki
N
Sato
D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology / Q000208:ethnology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D003577:Cytochrome P-450 Enzyme System; C465478:CYP4A11 protein, human; D042926:Cytochrome P-450 CYP4A