Common adipokine features of neonates and centenarians.
Adipose tissue seems to be a pivotal organ in the aging process. We investigated whether healthy aging could have its roots in a sound metabolic condition from the first year of life by evaluating leptin and adiponectin levels in neonates [33 adequate for gestational age (AGA) and 29 small for gestational age (SGA)], 48 centenarians, and 50 healthy elderly subjects. At birth, SGA neonates showed lower leptin levels (SGA 0.88 +/- 0.28; AGA 2.22 +/- 0.91 ng/mL; p < 0.05) and comparable adiponectin levels with respect to AGA. At 1 year, SGA showed increased leptin (SGA 1.74 +/- 0.28; AGA 1.31 +/- 0.19 ng/mL) and slightly reduced adiponectin concentrations (SGA 35.51 +/- 2.53; AGA 38.56 +/- 3.18 microg/mL) than AGA. Centenarians showed lower leptin (centenarians 18.71 +/- 3.78; elderly 34.81 +/- 7.27 ng/mL; p < 0.05) and higher adiponectin levels (centenarians 55.63 +/- 7.7; elderly 33.51 +/- 4.1 microg/mL; p < 0.05) than elderly subjects. Centenarians, like AGA infants during the first year of life, show a favorable adipokine profile, suggesting that the metabolic condition at early age could affect the longevity of an individual.
Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Università di Pavia, Fondazione IRCCS San Matteo, Pavia, Italy.
Cristina
C
Meazza
Giovanni
G
Vitale
Sara
S
Pagani
Davide
D
Castaldi
Giulia
G
Ogliari
Daniela
D
Mari
Kamilia
K
Laarej
Carmine
C
Tinelli
Mauro
M
Bozzola
D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over / Q000502:physiology*; D000375:Aging / Q000378:metabolism*; D001724:Birth Weight / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008297:Male
C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin