Polymorphism of flucloxacillin sodium.
The polymorphism of flucloxacillin sodium has not been discussed sufficiently so far. Flucloxacillin sodium which was crystallized with different solvents, was found to exist in amorphism and three crystal forms (I, II, III). This results were confirmed by infra-red (IR) spectra, thermogravimetry (TG), X-ray diffraction analysis (XRD) and equilibrium solubility. It is noticed that form III has very good solubility in phosphate buffer solution, with an average solubility of 0.86 g (20-40 degrees C). However, more efforts are needed to carry out and decide whether this form can be used for industrial production.
College of Chemical and Biological Engineering, Guilin University of Technology, Guilin, China.
Xiao-Yin
XY
Zhou
Zheng
Z
Liu
Miao-Miao
MM
Wang
Yan-Hong
YH
Li
Guo-Cheng
GC
Han
Xiao-Zhen
XZ
Feng
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004055:Differential Thermal Analysis; D005436:Floxacillin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007536:Isomerism; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D005436:Floxacillin