Antimicrobial chemical constituents from the endophytic fungus Phomopsis sp. from Notobasis syriaca.
Phomosine K (1), a new phomosine derivative, has been isolated from Phomopsis sp., in addition to six known compounds: phomosine A (2), phenylalanine amide (3), 2-hydroxymethyl-4beta,5alpha,6beta-trihydroxycyclohex-2-en (4), (-)-phyllostine (5), (+)-epiepoxydon (6), and (+)-epoxydon monoacetate (7). Preliminary studies showed that compound 1 had strong antibacterial activity, while compounds 4-7 showed good antifungal, antibacterial, and algicidal properties, except compounds 4 and 6, which lacked antifungal activity.
Department of Chemistry, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. Hidayat110@gmail.com
Hidayat
H
Hussain
Michel Kenne
MK
Tchimene
Ishtiaq
I
Ahmed
Kathrin
K
Meier
Michael
M
Steinert
Siegfried
S
Draeger
Barbara
B
Schulz
Karsten
K
Krohn
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*
D000890:Anti-Infective Agents