Engineering stem cell expansion.
In this issue of Cell Stem Cell, Csaszar et al. (2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density. This approach enhances the generation of precursors with potential therapeutic utility.
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA. lbernste@fhcrc.org
Irwin D
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Bernstein
Colleen
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D000818:Animals; D003198:Computer Simulation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans