New insight puts CRAF in sight as a therapeutic target.
By selectively depleting components of the RAF-MEK-ERK pathway in transgenic mice, it is now shown in 2 studies that CRAF is critical for signaling to MEK downstream of oncogenic Kras and that BRAF is not required.
Signal Transduction Team, Division of Tumour Biology, The Institute of Cancer Research, London, United Kingdom.
Ana Paula
AP
Rebocho
Richard
R
Marais
D000818:Animals; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics* / Q000378:metabolism*; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism*
D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins