Effects of acidic polysaccharides from gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet.
The effects of acidic polysaccharides purified from Gastrodia rhizome on blood pressure and serum lipid levels in spontaneously hypertensive rats (SHR) fed a high-fat diet were investigated. Acidic polysaccharides were purified from crude polysaccharides by DEAE-Sepharose CL-6B. Thirty-six male SHR were randomly divided into three groups: Gastrodia rhizome crude polysaccharide (A), acidic polysaccharide (B) groups, and a control group (C). A 5-week oral administration of all treatment groups was performed daily in 3- to 8-week-old SHRs with a dose of 6 mg/kg of body weight/day. After 5 weeks of treatment, total cholesterol in the acidic polysaccharide group, at 69.7 ± 10.6 mg/dL, was lower than in the crude polysaccharide group (75.0 ± 6.0 mg/dL) and the control group (89.2 ± 7.4 mg/dL). In addition, triglyceride and low-density lipoprotein cholesterol levels in the acidic polysaccharide group were lower than in the crude polysaccharide and control groups. The atherogenic index of the acidic polysaccharide group was 46.3% lower than in the control group. Initial blood pressure after the initial three weeks on the high-fat diet averaged 195.9 ± 3.3 mmHg among all rats. Compared with the initial blood pressure, the final blood pressure in the control group was increased by 22.8 mmHg, whereas it decreased in the acidic polysaccharide group by 14.9 mmHg. These results indicate that acidic polysaccharides from Gastrodia rhizome reduce hypertension and improve serum lipid levels.
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea.
Ok-Hwan
0000-0001-6855-3136
OH
Lee
Department of Hotel Culinary Arts and Food Service, Hyejeon College, Hongseong 350-702, Korea.
Kyung-Im
KI
Kim
Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
Chan-Kyu
CK
Han
Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
Young-Chan
YC
Kim
Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
Hee-Do
HD
Hong
D000818:Animals; D000959:Antihypertensive Agents / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood; D002855:Chromatography, Thin Layer; D059305:Diet, High-Fat; D031668:Gastrodia / Q000378:metabolism*; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D011134:Polysaccharides / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D027343:Rhizome / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D008078:Cholesterol, LDL; D008055:Lipids; D011134:Polysaccharides; D014280:Triglycerides