Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.
The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.
Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195-7923, USA. henryou@u.washington.edu
Henry
H
Ou
Julian A
JA
Simon
Edwin W
EW
Rubel
David W
DW
Raible
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects* / Q000473:pathology; D053403:Lateral Line System / Q000187:drug effects* / Q000473:pathology; D008403:Mass Screening / Q000379:methods*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018675:Toxicity Tests / Q000379:methods*; D015027:Zebrafish
D018696:Neuroprotective Agents