Evaluation of antiinflammatory and analgesic activities of alcoholic extract of Kaempferia galanga in rats.
Alcoholic extract of Kaempferia galanga was tested for analgesic and antiinflammatory activities in animal models. Three doses, 300 mg/kg, 600 mg/kg and 1200 mg/kg of the plant extract prepared as a suspension in 2 ml of 2% gum acacia were used. Acute and sub acute inflammatory activities were studied in rats by carrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was aspirin 100 mg/kg. Two doses 600 mg/kg and 1200 mg/kg of plant extract exhibited significant (P<0.001) antiinflammatory activity in carrageenan model and cotton pellet granuloma model in comparison to control. Analgesic activity was studied in rats using hot plate and tail-flick models. Codeine 5 mg/kg and vehicle served as standard and control respectively. The two doses of plant extract exhibited significant analgesic activity in tail flick model (P<0.001) and hot plate model (P<0.001) in comparison to control. In conclusion K. galanga possesses antiinflammatory and analgesic activities.
Department of Pharmacology, Kasturba Medical College, Manipal - 576 104. drmohan7amberkar@gmail.com
Amberkar Mohanbabu
AM
Vittalrao
Tara
T
Shanbhag
Meena
M
Kumari
K L
KL
Bairy
Smita
S
Shenoy
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D030521:Zingiberaceae
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts