Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease.
We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22 months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA.
Jinghong
J
Kou
Min
M
Song
Abhinandan
A
Pattanayak
Jeong-Eun
JE
Lim
Junling
J
Yang
Dongfeng
D
Cao
Ling
L
Li
Ken-ichiro
K
Fukuchi
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D023582:Alzheimer Vaccines / Q000276:immunology* / Q000627:therapeutic use; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D016657:Cerebral Amyloid Angiopathy / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000276:immunology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D019821:Simvastatin / Q000627:therapeutic use*
D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin