Cardiovascular and renal effects of hyperuricaemia and gout.
A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease. All things considered, serum uric acid may induce cardiovascular and kidney events both directly and indirectly by promoting other well-known mechanisms of damage. While asymptomatic hyperuricemia is currently not considered to be an indication for urate lowering therapy, there is growing evidence indicating a linear relationship between pharmacological reduction in serum uric acid and incidence of cardiovascular and renal events.
Department of Cardionephrology, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la ricerca sul Cancro, Genoa, Italy. francesca.viazzi@unige.it
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Leoncini
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D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D048909:Diabetes Complications / Q000097:blood; D018450:Disease Progression; D019317:Evidence-Based Medicine; D014943:Global Health; D006073:Gout / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D033461:Hyperuricemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D015201:Meta-Analysis as Topic; D024821:Metabolic Syndrome / Q000097:blood; D009422:Nervous System Diseases / Q000097:blood; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D006074:Gout Suppressants; D014527:Uric Acid