Evaluation of the trachea and intrathoracic airways by the acoustic reflection method in children with cystic fibrosis.
Tracheomalacia has been observed in older patients with cystic fibrosis (CF). The acoustic reflection method (ARM) allows a noninvasive calculation of the longitudinal cross-sectional area of the trachea (MTAv) and the airway resistance (Raw). ARM measurements were performed in 20 CF children and 20 controls during spontaneous breathing (SB), forced inspiration (FI), and forced expiration (FE). The mean MTAv value was comparable in the CF patients and the control subjects during SB, FI, and FE. The Raw was also comparable during SB and FI. However, the Raw during FE was higher in the CF patients than in the control subjects (7.9±2.3 vs. 5.0±1.5 cm H2O l(-1) s(-1), respectively, p<0.001). In the patients with CF, only the Raw during FE correlated with the predicted forced expiratory volume in 1s (R2=0.37, p=0.04). The tracheal cross-sectional area measured by the ARM is normal in children with CF but the increase in Raw during FE suggests an increase in intrathoracic airway distensibility.
UPMC University Paris 06, France.
Nicolas
N
Leboulanger
Bruno
B
Louis
Harriet
H
Corvol
Adriana
A
Ramirez
Rédouane
R
Fodil
Frédéric
F
Lofaso
Brigitte
B
Fauroux
D000162:Acoustics; D000293:Adolescent; D000403:Airway Resistance; D001980:Bronchi / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000503:physiopathology*; D006801:Humans; D012119:Respiration; D014132:Trachea / Q000473:pathology* / Q000503:physiopathology; D055090:Tracheomalacia / Q000503:physiopathology*