Antiviral efficacy of oseltamivir against avian influenza virus in avian species.
Avian influenza is one of the most contagious viral diseases in bird species and, increasingly, interspecies transmission to mammalian species has been reported. Prevention and eradication of avian influenza virus (AIV) infection in birds may require vaccines as part of a comprehensive program including biosecurity, culling, diagnostics, and surveillance. However, for valuable bird species in zoos, novel eradication strategies are needed, including antiviral treatments. The present study evaluated the anti-influenza efficacy of the potent neuraminidase inhibitor oseltamivir in avian species using the orders Galliformes (chickens) and Anseriformes (ducks). Viral replication of low pathogenic AIV was significantly reduced in the chicken model and completely reduced in the duck model. Anti-influenza drug administration to valuable bird species with an appropriate extrapolation approach could be useful for control of AIV in combination with active surveillance and vaccination strategies. Further, evaluation of oseltamivir against highly pathogenic avian influenza (HPAI) using avian models would be needed to optimize the oseltamivir application guideline for HPAI control.
Avian Disease Laboratory, Veterinary Science Research Institute, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea.
Dong-Hun
DH
Lee
Yu-Na
YN
Lee
Jae-Keun
JK
Park
Seong-Su
SS
Yuk
Jae-Won
JW
Lee
Jong-In
JI
Kim
Jin Soo
JS
Han
Joong-Bok
JB
Lee
Seung-Yong
SY
Park
In-Soo
IS
Choi
Chang-Seon
CS
Song
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002645:Chickens; D004372:Ducks; D005585:Influenza in Birds / Q000188:drug therapy*; D053139:Oseltamivir / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms
D000998:Antiviral Agents; D053139:Oseltamivir