A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.
BACKGROUND
Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers.


OBJECTIVE
Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT.


METHODS
5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT.


CONCLUSIONS
In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden. Cecilia.Svedman@skane.se
Cecilia
C
Svedman
Malin
M
Engfeldt
Anne Marie
AM
Api
Valerie T
VT
Politano
Donald V
DV
Belsito
Marlene
M
Isaksson
Magnus
M
Bruze
D000485:Allergens / Q000009:adverse effects; D000890:Anti-Infective Agents / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology*; D005054:Eugenol / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods*; D010865:Pilot Projects
D000485:Allergens; D000890:Anti-Infective Agents; D005054:Eugenol