Dehydrogenative Heck coupling of biologically relevant N-heteroarenes with alkenes: discovery of fluorescent core frameworks.
A Pd/Cu-catalyzed dehydrogenative Heck coupling is established that allows direct alkenylation of various biologically relevant N-heteroarenes with alkenes. The resulting π-extended alkenylated N-heteroarenes exhibit interesting fluorescent properties and have proven to be potentially useful fluorescent probes for bioimaging.
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
Yumin
Y
Huang
Feijie
F
Song
Zhen
Z
Wang
Peihua
P
Xi
Ningjie
N
Wu
Zhigang
Z
Wang
Jingbo
J
Lan
Jingsong
J
You
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D018613:Microscopy, Confocal; D010165:Palladium / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D014970:Xanthines / Q000737:chemistry
D000475:Alkenes; D005456:Fluorescent Dyes; D011687:Purines; D014970:Xanthines; D010165:Palladium; D003300:Copper