Safety of prophylactic intracameral moxifloxacin use in cataract surgery.
OBJECTIVE
To evaluate posterior and anterior segment safety of an intracameral injection of moxifloxacin as prophylaxis for endophthalmitis in cataract surgery.


METHODS
In this study, 60 eyes of 60 patients were included. In the first group, only 5% povidine iodine drop was administrated to 30 patients at the end of the surgery, while 30 patients were treated with intracameral moxifloxacin (250 μg/0.050 mL) additionally in the second group. Visual acuity, intraocular pressure, corneal pachymetry, corneal clarity, and edema and retinal thickness were evaluated preoperatively and for day 3 postoperatively for each group and were compared.


RESULTS
Mean preoperative visual acuity was 0.7 ± 0.9 LogMAR in both groups 1 and 2, while mean postoperative visual acuity was 0.05 ± 1.00 LogMAR in both groups. Preoperative and postoperative intraocular pressure averaged 13.2 ± 2.0 and 13.2 ± 2.1 mmHg, respectively, in the first group, while preoperative and postoperative intraocular pressure was 14.9 ± 2.1 and 14.3 ± 2.0, respectively, in the second group. Preoperative and postoperative visual acuity changes and intraocular pressure changes were not significantly different between 2 groups. There was no single case of corneal edema. In the first group, preoperative pachymetry was 523 ± 44 and postoperative pachmetry was 536 ± 45 μm, while in the second group preoperative pachymetry was 527 ± 43 and postoperative pachymetry was 543 ± 42 μm. Preoperative and postoperative pachymetry changes were not significantly different between 2 groups. Mean preoperative macular thickness in the first group was 188 ± 7.73 μm, while it was measured as 189 ± 7.75 μm postoperatively. In the second group, mean preoperative macular thickness was 188 ± 8.89 μm, while it was 189 ± 9.61 μm postoperatively. Preoperative and postoperative optical coherence tomography (OCT) measure changes were not significantly different between the 2 groups. No study-related adverse events were noted.


CONCLUSIONS
There was no increased safety risk associated with a 250 μm/0.050 mL intracameral injection of moxifloxacin, which appears to be safe in the prophylaxis of endophthalmitis after cataract surgery.
Selcuklu Faculty of Medicine, Selcuk University, Konya, Turkey. benguekinci@hotmail.com
Bengu
B
Ekinci Koktekir
Bekir Sitki
BS
Aslan
D000368:Aged; D001372:Aza Compounds / Q000009:adverse effects* / Q000627:therapeutic use*; D002386:Cataract / Q000628:therapy*; D002387:Cataract Extraction / Q000379:methods*; D003315:Cornea / Q000187:drug effects* / Q000601:surgery*; D009877:Endophthalmitis / Q000517:prevention & control*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008269:Macular Edema / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D018918:Phacoemulsification / Q000009:adverse effects / Q000379:methods; D056990:Post-Exposure Prophylaxis / Q000379:methods; D011804:Quinolines / Q000009:adverse effects* / Q000627:therapeutic use*; D012160:Retina / Q000187:drug effects / Q000601:surgery; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000187:drug effects
D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin