Wound healing activity of Elaeis guineensis leaf extract ointment.
Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia; E-Mail:  latha_usm@yahoo.com.
Sreenivasan
S
Sasidharan
Selvarasoo
S
Logeswaran
Lachimanan Yoga
LY
Latha
D000818:Animals; D028023:Arecaceae / Q000737:chemistry* / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009824:Ointments / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000201:enzymology / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D009824:Ointments; D010936:Plant Extracts; D020782:Matrix Metalloproteinases