Association of major histocompatibility complex class 1 chain-related gene a dimorphism with type 1 diabetes and latent autoimmune diabetes in adults in the Algerian population.
Major histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.
Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene, Algiers, Algeria. raache_ipa@yahoo.fr
Rachida
R
Raache
Khadidja
K
Belanteur
Habiba
H
Amroun
Amel
A
Benyahia
Amel
A
Heniche
Malha
M
Azzouz
Safia
S
Mimouni
Thibaud
T
Gervais
Dominique
D
Latinne
Aissa
A
Boudiba
Nabila
N
Attal
Mohamed Cherif
MC
Abbadi
D000293:Adolescent; D000328:Adult; D000462:Algeria; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A