Adverse drug events in the emergency department: why genetics matters in practice.
A recent clinical research study with a case study approach is used to illustrate the importance of translational research in the role of the advanced practice nurse. The case study module used in this column is "Adverse Drug Events in the Emergency Department: Why Genetics Matters in Practice." The study results showed that patients taking multiple drugs metabolized through the cytochrome P450 enzyme system had a higher prevalence of drug-drug exposure. These drug-drug exposures may lead to potentially serious drug-drug interactions. The implications and clinical relevance of these findings for advance practice nurses are discussed.
Clemson University School of Nursing, Clemson, South Carolina 29634, USA. echisma@clemon.edu
Elisabeth
E
Chismark
Dian Dowling
DD
Evans
D057179:Advanced Practice Nursing; D000701:Analgesics, Opioid / Q000378:metabolism / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D016529:Emergency Nursing; D004636:Emergency Service, Hospital; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D016015:Logistic Models; D017116:Low Back Pain / Q000188:drug therapy* / Q000201:enzymology / Q000453:epidemiology; D008875:Middle Aged; D015399:Nursing Research; D057170:Translational Research, Biomedical
D000701:Analgesics, Opioid; D004791:Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System