Replication timing: the early bird catches the worm.
Different replication origins in eukaryotes are activated at different times during S phase. New work indicates that the time at which an origin fires is related to its ability to recruit replication initiation factors that are limiting within the cell.
Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, UK.
Max E
ME
Douglas
John F X
JF
Diffley
D002352:Carrier Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins