Fluoride release from newly marketed fluoride varnishes.
OBJECTIVE
New fluoride varnishes have been marketed that reportedly release more fluoride (Enamel Pro) or release fluoride more slowly (Vanish XT). The purpose of this study was to compare the amount and rate of fluoride release of new fluoride varnishes with other traditional fluoride varnishes.


METHODS
Extracted molars were cut into block sections. The enamel surfaces of the sections were painted with Enamel Pro, Duraphat, Vanish, or Vanish XT fluoride varnishes. One group was not treated and served as a negative control. The tooth sections were immersed in artificial saliva. The concentration of fluoride in parts per million was measured after the first 30 minutes, daily for the first week, and weekly until the level was below the limit of detection. Fluoride release was plotted over time. Cumulative fluoride release and rate of release (slope) were analyzed using one-way ANOVA/Tukey (α = .05).


RESULTS
Enamel Pro had the greatest cumulative fluoride release. There was no significant difference between Duraphat and Vanish. Vanish XT had the lowest cumulative fluoride release. The rate of fluoride release from 1 week to limit of detection was Enamel Pro > Vanish > Duraphat > Vanish XT.


CONCLUSIONS
The two newly marketed fluoride varnishes (Enamel Pro and Vanish XT) had significantly different fluoride release from the two conventional fluoride varnishes (Duraphat and Vanish).
Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health Science Center, San Antonio, TX, USA.
Beth L
BL
Jablonowski
Joseph A
JA
Bartoloni
Donna M
DM
Hensley
Kraig S
KS
Vandewalle
D002327:Cariostatic Agents / Q000737:chemistry*; D003692:Delayed-Action Preparations; D003743:Dental Enamel; D004058:Diffusion; D005459:Fluorides / Q000737:chemistry*; D005460:Fluorides, Topical / Q000737:chemistry*; D006801:Humans; D017736:Ion-Selective Electrodes; D008422:Materials Testing; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000737:chemistry; D013997:Time Factors
D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D005460:Fluorides, Topical; D012464:Saliva, Artificial; C023807:sodium fluoride topical preparation; D012969:Sodium Fluoride; D005459:Fluorides