Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation.
We experimentally demonstrate the use of continuous, time-delayed, feedback stimulation for controlling the synchronization of neuron action potentials. Phase-based models were experimentally constructed from a single synaptically isolated cultured hippocampal neuron. These models were used to determine the stimulation parameters necessary to produce the desired synchronization behavior in the action potentials of a pair of neurons coupled through a global time-delayed interaction. Measurements made using a dynamic clamp system confirm the generation of the synchronized states predicted by the experimentally constructed phase model. This model was then utilized to extrapolate the feedback stimulation parameters necessary to disrupt the action potential synchronization of a large population of globally interacting neurons.
Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA. crusin@bcm.edu
Craig G
CG
Rusin
Sarah E
SE
Johnson
Jaideep
J
Kapur
John L
JL
Hudson
D000200:Action Potentials; D000818:Animals; D057005:Bioengineering; D002478:Cells, Cultured; D004558:Electric Stimulation; D025461:Feedback, Physiological; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D051381:Rats