The ability of β-cells to compensate for insulin resistance is restored with a reduction in excess growth hormone in Korean acromegalic patients.
The aim of this study was to assess the prevalence of diabetes and to study the effects of excess growth hormone (GH) on insulin sensitivity and β-cell function in Korean acromegalic patients. One hundred and eighty-four acromegalic patients were analyzed to assess the prevalence of diabetes, and 52 naïve acromegalic patients were enrolled in order to analyze insulin sensitivity and insulin secretion. Patients underwent a 75 g oral glucose tolerance test with measurements of GH, glucose, insulin, and C-peptide levels. The insulin sensitivity index and β-cell function index were calculated and compared according to glucose status. Changes in the insulin sensitivity index and β-cell function index were evaluated one to two months after surgery. Of the 184 patients, 17.4% were in the normal glucose tolerance (NGT) group, 45.1% were in the pre-diabetic group and 37.5% were in the diabetic group. The insulin sensitivity index (ISI(0,120)) was significantly higher and the HOMA-IR was lower in the NGT compared to the diabetic group (P = 0.001 and P = 0.037, respectively). The ISI(0,120) and disposition index were significantly improved after tumor resection. Our findings suggest that both insulin sensitivity and β-cell function are improved by tumor resection in acromegalic patients.
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Soo Kyoung
SK
Kim
Sunghwan
S
Suh
Ji In
JI
Lee
Kyu Yeon
KY
Hur
Jae Hoon
JH
Chung
Moon-Kyu
MK
Lee
Yong-Ki
YK
Min
Jae Hyeon
JH
Kim
Jong-Hyun
JH
Kim
Kwang-Won
KW
Kim
D000172:Acromegaly / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000453:epidemiology; D056910:Republic of Korea
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D019382:Human Growth Hormone