[Biomarker of bone destruction].
Patients with rheumatoid arthritis (RA) often have progression of bone destruction owing to chronic inflammation. Treatment for bone destruction is still insufficient in these patients although goal of treatment has become remission since biologics have been used widely. It is shown that collagen cross-linked C-peptide (CTX- I ) and tartrate-resistant acid phosphatase (TRACP) have correlated with bone destruction in patients with RA, in addition, evidence of new biomarker such as hepatocyte growth factor and macrophage inhibitory factor have been accumulated recently. These biomarkers may help evaluation of bone quality clinically.
Department of Rheumatism, Tokyo Metropolitan Bokuto Hospital, Japan.
Yuichi
Y
Nagase
Sakae
S
Tanaka
D000135:Acid Phosphatase / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001842:Bone and Bones / Q000473:pathology*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D053759:Interleukin-23; D007527:Isoenzymes / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood; D008297:Male; D010455:Peptides / Q000097:blood; D000071681:Tartrate-Resistant Acid Phosphatase
D015415:Biomarkers; D024042:Collagen Type I; D053759:Interleukin-23; D007527:Isoenzymes; D008263:Macrophage Migration-Inhibitory Factors; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D017228:Hepatocyte Growth Factor; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase