A new iridoid glycoside from the roots of Dipsacus asper.
A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4',4''-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ₂₅₋₃₅ induced cell death in PC12 cells.
State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China. yzl1950@tom.com.
De
D
Ji
Chunfeng
C
Zhang
Jingzhi
J
Li
Haowei
H
Yang
Jingyang
J
Shen
Zhonglin
Z
Yang
D000818:Animals; D049917:Dipsacaceae / Q000737:chemistry*; D057888:Iridoid Glucosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D057888:Iridoid Glucosides