Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement.
OBJECTIVE
Compare outcomes with vaginal gel versus intramuscular progesterone replacement in donor oocyte recipients.


METHODS
A single-center retrospective analysis (January 2004-December 2006) evaluated pregnancy outcomes (serum human chorionic gonadotropin, implantation, clinical pregnancy, delivery, total pregnancy loss rates) for 225 recipients of embryos from donor (aged <32 years) oocytes. Vaginal progesterone gel (Crinone® 8%; 90 mg twice daily; n = 105) or intramuscular progesterone (50 mg once daily; n = 120) was started the afternoon of oocyte retrieval and continued until a negative pregnancy test or 10 weeks' gestation.


RESULTS
There were no statistically significant differences between groups for the five pregnancy outcomes; numerical results favored vaginal progesterone in all cases. Confidence intervals showed vaginal gel was within, or <1% from, a noninferiority limit of 10% versus intramuscular progesterone for four of five pregnancy outcomes.


CONCLUSIONS
Pregnancy outcomes were comparable for progesterone replacement with vaginal gel and intramuscular progesterone in an oocyte donation program.
Boston IVF, Inc., Waltham, MA 02451, USA. BBerger@BOSTONIVF.com
Brian M
BM
Berger
James A
JA
Phillips
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D020249:Hormone Replacement Therapy; D006801:Humans; D007246:Infertility / Q000097:blood / Q000628:therapy*; D007273:Injections, Intramuscular; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000627:therapeutic use; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014622:Vaginal Creams, Foams, and Jellies
D006063:Chorionic Gonadotropin; C400424:Crinone; D003692:Delayed-Action Preparations; D014622:Vaginal Creams, Foams, and Jellies; D011374:Progesterone