Density gradient multilayer polymerization for creating complex tissue.
An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.
Biomedical Sciences Program, University of California at San Diego, La Jolla, 92093-0600, USA.
Jerome V
JV
Karpiak
Yogesh
Y
Ner
Adah
A
Almutairi
D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013395:Sucrose / Q000737:chemistry; D023822:Tissue Engineering; D014283:Triiodobenzoic Acids / Q000737:chemistry
D020100:Hydrogels; D011108:Polymers; D014283:Triiodobenzoic Acids; D013395:Sucrose; C044834:iodixanol