Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells.
The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.
Chemistry of Functional Molecule, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cyo, Tokushima, Japan. imagawa@ph.bunri-u.ac.jp
Hiroshi
H
Imagawa
Hayato
H
Saijo
Hitomi
H
Yamaguchi
Ken
K
Maekawa
Takahiro
T
Kurisaki
Hirofumi
H
Yamamoto
Mugio
M
Nishizawa
Masataka
M
Oda
Michiko
M
Kabura
Masahiro
M
Nagahama
Jun
J
Sakurai
Miwa
M
Kubo
Megumi
M
Nakai
Kosho
K
Makino
Mitsuko
M
Ogata
Hironobu
H
Takahashi
Yoshiyasu
Y
Fukuyama
D000818:Animals; D004224:Diterpenes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005456:Fluorescent Dyes / Q000737:chemistry; D008958:Models, Molecular; D016501:Neurites / Q000187:drug effects* / Q000648:ultrastructure; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D016716:PC12 Cells; D051381:Rats; D027925:Viburnum / Q000737:chemistry*
D004224:Diterpenes; D005456:Fluorescent Dyes