The ins and outs of inflammatory cells in atheromata.
Macrophage accumulation characterizes the formation of atherosclerotic plaques. Recent work in Nature Immunology (van Gils et al., 2012) demonstrates that the neuroimmune guidance cue netrin-1 can retain macrophages in atherosclerotic lesions, thus promoting atherosclerosis.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Filip K
FK
Swirski
Matthias
M
Nahrendorf
Peter
P
Libby