Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics.
In the last few decades, coordination complexes based on d(6) metal centres and polypyridyl ligand architectures been developed as structure- and site-specific reversible DNA binding agents. Due to their attractive photophysical properties, much of this research has focused on complexes based on ruthenium(II) centres and, more recently, attention has turned to the use of these complexes in biological contexts. As the rules that govern the cellular uptake and cellular localisation of such systems are determined they are finding numerous applications ranging from imaging to therapeutics. This review illustrates how the interdisciplinary nature of this research-which takes in synthetic chemistry, biophysical and in cellulo studies-makes this an exciting area in which an array of further applications are likely to emerge.
Department of Chemistry, University of Sheffield, Sheffield, UK. m.gill@sheffield.ac.uk
Martin R
MR
Gill
Jim A
JA
Thomas
D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use* / Q000633:toxicity; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D015335:Molecular Probes; D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium; D004247:DNA; C023666:pyridine