EML4-ALK fusion gene in Korean non-small cell lung cancer.
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
Guang
G
Jin
Hyo-Sung
HS
Jeon
Eung Bae
EB
Lee
Hyo-Gyoung
HG
Kang
Seung Soo
SS
Yoo
Shin Yup
SY
Lee
Jae Hee
JH
Lee
Sung Ick
SI
Cha
Tae In
TI
Park
Chang Ho
CH
Kim
Sang Hoon
SH
Jheon
Jae Yong
JY
Park
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000235:genetics*; D005091:Exons; D005260:Female; D006801:Humans; D007438:Introns; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000737:chemistry / Q000235:genetics*; D056910:Republic of Korea; D017423:Sequence Analysis, RNA; D012907:Smoking
C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion