Common variants at 11p13 are associated with susceptibility to tuberculosis.
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Thorsten
T
Thye
Ellis
E
Owusu-Dabo
Fredrik O
FO
Vannberg
Reinout
R
van Crevel
James
J
Curtis
Edhyana
E
Sahiratmadja
Yanina
Y
Balabanova
Christa
C
Ehmen
Birgit
B
Muntau
Gerd
G
Ruge
Jürgen
J
Sievertsen
John
J
Gyapong
Vladyslav
V
Nikolayevskyy
Philip C
PC
Hill
Giorgio
G
Sirugo
Francis
F
Drobniewski
Esther
E
van de Vosse
Melanie
M
Newport
Bachti
B
Alisjahbana
Sergey
S
Nejentsev
Tom H M
TH
Ottenhoff
Adrian V S
AV
Hill
Rolf D
RD
Horstmann
Christian G
CG
Meyer
D016022:Case-Control Studies; D018797:Cell Cycle Proteins; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D005869:Ghana; D006801:Humans; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D000072260:RNA Splicing Factors; D014376:Tuberculosis / Q000235:genetics*
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; C419554:WTAP protein, human