[Obtaining and characteristic of Streptomyces globisporus 1912 mutants with high biosynthesis of landomycin e].
Eight highly productive UV-induced mutants of Streptomyces globisporus 1912 with high biosynthesis of landomycin E were isolated, their isolation frequency being 2 x 10(-3). Mutants 1-1, 1-4-1, 1-1y, 1-2y, 4-1, 1-2 produced 175-187.5 mg of landomycine E and 1-1b, 4-1-1 and 1-3--80-100 mg per 1 liter of soybean agar after 48 hours of cultivation The mutant 4-1-1 had the highest antibiotic activity and middle level of landomycin E production.
B Ia
BIa
Lavrinchuk
K A
KA
Kotenko
S L
SL
Golembiovs'ka
B P
BP
Matseliukh
D000617:Aminoglycosides / Q000096:biosynthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use; D002855:Chromatography, Thin Layer; D003116:Color; D003470:Culture Media; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy; D010084:Oxidation-Reduction; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D014466:Ultraviolet Rays
D000617:Aminoglycosides; D000970:Antineoplastic Agents; D003470:Culture Media; C113593:landomycin E