CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo.
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation.
Clinical and Experimental Neuroscience, University of Murcia, Murcia, Spain.
Maria Angeles
MA
Carrillo-de Sauvage
Aurora
A
Gómez
Carmen María
CM
Ros
Francisco
F
Ros-Bernal
Eduardo D
ED
Martín
Ana
A
Perez-Vallés
José M
JM
Gallego-Sanchez
Emiliano
E
Fernández-Villalba
Carlos
C
Barcia
Carlos
C
Barcia
Maria-Trinidad
MT
Herrero
D001253:Astrocytes / Q000378:metabolism* / Q000502:physiology; D001921:Brain / Q000166:cytology*; D018932:Chemokine CCL2 / Q000378:metabolism / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003952:Diagnostic Imaging; D005910:Glioma / Q000473:pathology*; D006801:Humans; D059906:Neuroimaging; D013601:T-Lymphocytes / Q000166:cytology*
C111835:CCL2 protein, human; D018932:Chemokine CCL2