Diterpenoids and triterpenoids with potential anti-inflammatory activity from the leaves of Aglaia odorata.
Chemical investigation of the leaves of the oriental medicinal plant Aglaia odorata resulted in the isolation of five compounds: two dolabellane diterpenoids, two dammarane triterpenoids and a protostane triterpenoid, along with twenty known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR spectroscopic data with those reported in the literature. The anti-inflammatory activities of all compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Eleven compounds possessed potent nitric oxide inhibitory activity with IC(50) values ranging from 2.1 to 14.2 μM, these being better than that of the positive control, indomethacin (IC(50)=14.5 μM). In addition, three compounds exhibited significant activity against PGE(2) release with IC(50) values of 2.6, 16.1 and 23.0 μM.
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Orapun
O
Yodsaoue
Jarinthon
J
Sonprasit
Chatchanok
C
Karalai
Chanita
C
Ponglimanont
Supinya
S
Tewtrakul
Suchada
S
Chantrapromma
D031602:Aglaia / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D015232:Dinoprostone / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D014315:Triterpenes; D009569:Nitric Oxide; D015232:Dinoprostone; D007213:Indomethacin