Cooperative catalytic reactions using distinct transition-metal catalysts: ruthenium- and copper-catalyzed enantioselective propargylic alkylation.
The enantioselective propargylic alkylation of propargylic alcohols with β-ketoesters in the presence of a thiolate-bridged diruthenium complex and a copper complex as co-catalyst affords the corresponding propargylic alkylated products in excellent yields as a mixture of two diastereoisomers with high enantioselectivity (up to 95% enantiomeric excess (ee)). The findings reported herein not only open up a new type of enantioselective propargylic substitution reaction, but also a new aspect of cooperative catalytic reactions using distinct transition metals to realize a useful transformation that cannot be achieved by a single catalyst.
Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Tokyo, 113-8656, Japan.
Masahiro
M
Ikeda
Yoshihiro
Y
Miyake
Yoshiaki
Y
Nishibayashi