Increased hyaluronan levels and decreased dendritic cell activation are associated with tumor invasion in murine lymphoma cell lines.
Hyaluronan (HA), a component of the extracellular matrix surrounding tumors, modulates tumor progression and the immune response. Dendritic cells (DC) may tolerize or stimulate immunity against cancer. In this report, we study the association between tumor progression, HA levels and DC activation in a lymphoma model. Mice injected with the cells with highest invasive capacity (LBR-) presented increased HA in serum and lymph nodes, and decreased DC activation in infiltrated lymph nodes and liver. These findings could be related to lack of an effective antitumor immune response and suggest that serum HA levels could have a prognostic value in hematological malignancies.
Department of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, IDEHU-CONICET, Buenos Aires, Argentina. rosaliacordorusso@yahoo.com.ar
Rosalia I
RI
Cordo Russo
Glenda
G
Ernst
Silvina
S
Lompardía
Guillermo
G
Blanco
Élida
É
Álvarez
Mariana G
MG
Garcia
Silvia
S
Hajos
D000818:Animals; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000276:immunology*; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D006820:Hyaluronic Acid / Q000097:blood / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase / Q000235:genetics / Q000378:metabolism; D008223:Lymphoma / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009361:Neoplasm Invasiveness
D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; D006821:Hyaluronoglucosaminidase