MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin.
Previous studies have shown that miR-203 acts as a tumor-suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR-203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR-203. Moreover, silencing of survivin recapitulated the effect of miR-203 on cell cycle progression, whereas overexpression of survivin reversed this effect. Additionally, qRT-PCR showed the reciprocal relationship between miR-203 and survivin in laryngeal cancer tissues. These findings indicate that miR-203 inhibits the proliferation of laryngeal carcinoma cells by directly targeting survivin, suggesting its application in anti-cancer therapeutics.
Department of Otolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Ka
K
Bian
Jing
J
Fan
Xiang
X
Zhang
Xin-Wei
XW
Yang
Hua-Yu
HY
Zhu
Lei
L
Wang
Jian-Yong
JY
Sun
Yan-Ling
YL
Meng
Peng-Cheng
PC
Cui
Shi-Yin
SY
Cheng
Jian
J
Zhang
Jing
J
Zhao
An-Gang
AG
Yang
Rui
R
Zhang
D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D059585:G1 Phase Cell Cycle Checkpoints / Q000235:genetics*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; C546703:MIRN203 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D000077022:Survivin