Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets.
It has been shown that infection of GB virus B (GBV-B), which is closely related to hepatitis C virus, develops acute self-resolving hepatitis in tamarins. In this study we sought to examine longitudinally the dynamics of viral and immunological status following GBV-B infection of marmosets and tamarins. Surprisingly, two of four marmosets but not tamarins experimentally challenged with GBV-B developed long-term chronic infection with fluctuated viremia, recurrent increase of alanine aminotransferase and plateaued titers of the antiviral antibodies, which was comparable to chronic hepatitis C in humans. Moreover, one of the chronically infected marmosets developed an acute exacerbation of chronic hepatitis as revealed by biochemical, histological, and immunopathological analyses. Of note, periodical analyses of the viral genomes in these marmosets indicated frequent and selective non-synonymous mutations, suggesting efficient evasion of the virus from antiviral immune pressure. These results demonstrated for the first time that GBV-B could induce chronic hepatitis C-like disease in marmosets and that the outcome of the viral infection and disease progression may depend on the differences between species and individuals.
Tsukuba Primate Research Center, National Institute of Biomedical Innovation Tsukuba, Japan.
Yuki
Y
Iwasaki
Ken-Ichi
K
Mori
Koji
K
Ishii
Noboru
N
Maki
Sayuki
S
Iijima
Tomoyuki
T
Yoshida
Sachi
S
Okabayashi
Yuko
Y
Katakai
Young-Jung
YJ
Lee
Akatsuki
A
Saito
Hiromi
H
Fukai
Nobuyuki
N
Kimura
Naohide
N
Ageyama
Sayaka
S
Yoshizaki
Tetsuro
T
Suzuki
Yasuhiro
Y
Yasutomi
Tatsuo
T
Miyamura
Mari
M
Kannagi
Hirofumi
H
Akari