The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review.
To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants.


CONCLUSIONS
There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this.
Department of Paediatrics, Juliana Children's Hospital, The Hague, The Netherlands. f.visser@amc.uva.nl
Fenna
F
Visser
Arwen J
AJ
Sprij
Frank
F
Brus
D015415:Biomarkers / Q000097:blood / Q000652:urine; D001851:Bone Diseases, Metabolic / Q000097:blood* / Q000652:urine*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000652:urine*; D015203:Reproducibility of Results
D015415:Biomarkers