[Research on relationship between tissue quantitative distribution of 3H-Achyranthes bidentata ecdysterone and channel-tropism of herbal drugs in mice].
OBJECTIVE
To study the relationship between tissue quantitative distribution and pharmacokinetics of 3H-achyranthes bidentata ecdysterone and the channel-tropism of herbal drugs in mice.


METHODS
3H-achyranthes bidentata ecdysterone was used as a tracer agent and injected into mice by the caudal vein. In 36 hours, the contents of the tracer agent of samples involving 9 different tracing phases and organ or tissue were determined in order to observe the dynamic quantitative distribution and excretion and pharmacokinetics of 3H-achyranthes bidentata ecdysterone and to understand the channel-tropism of herbal drugs achyranthes bidentata.


RESULTS
3H-achyranthes bidentata ecdysterone of same organs in different tracing phases and the contents of 3H-achyranthes bidentata ecdysterone in same tracing phases of different organs were significantly different (P<0.01). 3H-achyranthes bidentata ecdysterone was mainly distributed, in the liver, kidney, adrenal gland, small intestine and lung. The concentration-time profiles of achyranthes bidentata ecdysterone in rats injected into mice by the caudal vein were shown to fit a two-compartment open model with half-lives of (778.65 +/- 12.36) min, the elimination of achyranthes bidentata ecdysterone from plasma was found to be in accord with linear kinetics.


CONCLUSIONS
The above mentioned selective distribution of 3H-achyranthes bidentata ecdysterone basically coincides with the meridian affinity and zang fu selection of the traditional Chinese medicine drug Achyranthes bidentata. This study will provide a scientific basis for the channel-tropism of A. bidentata.
Department of Formulaology, Hebei Medical University, Shijiazhuang 050091, China.
Mishan
M
Wu
Suzhi
S
Zhao
Lizhong
L
Ren
Ru
R
Wang
Xia
X
Bai
Hongwei
H
Han
Bin
B
Li
Huayue
H
Chen
D029044:Achyranthes / Q000737:chemistry*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000378:metabolism / Q000493:pharmacokinetics*; D004441:Ecdysterone / Q000378:metabolism / Q000493:pharmacokinetics*; D007553:Isotope Labeling; D008297:Male; D016740:Meridians; D051379:Mice; D009928:Organ Specificity; D014018:Tissue Distribution; D014316:Tritium / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D014316:Tritium; D004441:Ecdysterone