A qualitative description of the peptide sharing between poliovirus and Homo sapiens.
In a companion paper, we reported that pentapeptides from human poliovirus 1, Mahoney strain, occur repeatedly in human proteins for a total of more than 18,000 overlaps. In the present study, we describe the distribution of the polio pentapeptides throughout biochemical pathways and networks characterizing functions and tissues in the human host. The present study might be of help to better define the poliovirus-host relationships as well as for designing peptide modules with anti-polio activity.
Department of Biochemistry and Molecular Biology, Universityof Bari, Bari, Italy.
Giovanni
G
Capone
Giuseppe
G
Novello
Simona Lucia
SL
Bavaro
Candida
C
Fasano
Antonella
A
Pesce Delfino
Anna Nunzia
AN
Polito
Darja
D
Kanduc
D006801:Humans; D009842:Oligopeptides / Q000235:genetics*; D017955:Poliovirus / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics*
D009842:Oligopeptides; D014764:Viral Proteins