[Endocrine disruptors and obesity: obesogens].
Incidence and prevalence of owerweight and obesity have greatly increased over the past three decades in almost all countries around the world. This phenomenon is not easily explained by lifestyle changes in populations with very different initial habits. This has led to consider the influence of other factors, the so-called endocrine disruptors, and more specifically obesogens. This study reviewed the available evidence about polluting chemical substances which may potentially be obesogens in humans: DES, genistein, bisphenol A, organotins (TBT, TPT), and phthalates. The first three groups of substances mainly act upon estrogen receptors, while organotins and phthalates activate PPARγ. It was concluded that evidence exists of the obesogenic effect of these chemical substances in tissues and experimental animals, but few data are available in humans.
Unidad de Investigación Compartida «Obesógenos» Sergas, Servicio de Endocrinología, Diabetes, Nutrición y Metabolismo, Universidad de Vigo, Vigo, España. ricardo.garcia.mayor@sergas.es
Ricardo V
RV
García-Mayor
Alejandra
A
Larrañaga Vidal
Maria F
MF
Docet Caamaño
Anunciación
A
Lafuente Giménez
D000818:Animals; D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000494:pharmacology / Q000633:toxicity; D004703:Endocrine System / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D019833:Genistein / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D006727:Hormone Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008297:Male; D009765:Obesity / Q000139:chemically induced*; D010636:Phenols / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D010795:Phthalic Acids / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011956:Receptors, Cell Surface / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D015262:Xenobiotics / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol; D052244:Endocrine Disruptors; D019833:Genistein; D006727:Hormone Antagonists; D010636:Phenols; D010795:Phthalic Acids; D011956:Receptors, Cell Surface; D014220:Trialkyltin Compounds; D015262:Xenobiotics; C006780:bisphenol A; D000098826:Bisphenol A Compounds