New production of 5-bromotoluhydroquinone and 4-O-methyltoluhydroquinone from the marine-derived fungus Dothideomycete sp.
The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5- bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillinresistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 microgram/ml, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2- picrylhydrazyl (DPPH) with IC(50) values of 11.0, 17.0, 12.0, and 7.0 microM, respectively, which were more active than the positive control, L-ascorbic acid (IC(50), 20.0 μM).
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Alain Simplice
AS
Leutou
Keumja
K
Yun
Hong Dae
HD
Choi
Jung Sook
JS
Kang
Byeng Wha
BW
Son
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism; D003470:Culture Media / Q000737:chemistry; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000378:metabolism; D005658:Fungi / Q000378:metabolism*; D006873:Hydroquinones / Q000302:isolation & purification* / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D003470:Culture Media; D016166:Free Radical Scavengers; D006873:Hydroquinones