Synthetic membrane active amphiphiles.
During the past several decades, various synthetic organic compounds that form pores in bilayer membranes have been prepared and studied. These membrane active amphiphiles have also proved to be useful in affecting the transport of molecules into or through the bilayer. This article discusses the evolution of these compounds and exemplifies recent applications such as enhancement of antimicrobial activity.
Center for Nanoscience, Department of Chemistry & Biochemistry, University of Missouri - Saint Louis, Saint Louis, MO 63121, USA. gokelg@umsl.edu
George W
GW
Gokel
Saeedeh
S
Negin
D000890:Anti-Infective Agents / Q000737:chemistry; D001692:Biological Transport; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial; D013501:Surface-Active Agents / Q000737:chemistry*
D000890:Anti-Infective Agents; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D013501:Surface-Active Agents