[Epigenetic modifications in cancer].
Abnormal function of genes and modified gene expression patterns play a major role in cancer. Scientists have been investigating origins of human cancer for decades and debating the relative roles of genetic and epigenetic abnormalities in the process. Growing evidence indicates that epigenetics abnormalities together with genetic defects take part in aberrant gene regulation in all stages of cancer development, and no cancer has been identified that has purely genetic or epigenetic background. Epigenetic modifications bring new insights into cancer diagnostics, prognostics and therapy.
Lääketieteellinen genetiikka, Haartman-instituutti.
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D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics*