[Influencing factors of long-mid term efficacy following percutaneous vertebroplasty in patients with osteoporosis].
OBJECTIVE
To determine the therapeutic efficacy and the influencing factors for the long/middle-term outcomes of percutaneous vertebroplasty (PVP) in the treatment of painful osteoporotic vertebral compression fractures (OVCFs).


METHODS
This prospective study recruited a total of 131 consecutive OVCF patients treated with PVP at a single institution from March 2005 to December 2009. There were 106 females and 25 males. Pre- and postoperative evaluations included a visual analog scale (VAS) for pain, the Roland-Morris disability questionnaire (RDQ) scores and patient activity levels. Various factors probably correlated with long-mid term efficacy were also analyzed.


RESULTS
Both VAS and RDQ scores decreased significantly (P < 0.05). And the activity levels showed significant post-therapeutic improvement (P < 0.01); Univariate and multivariate analysis showed that the influencing factors for the long/middle-term efficacy were age, number of OVCF(s) per time, activity level after discharge and newly occurring OVCF (Z = -2.03, -2.68, 5.38 and -1.73; P = 0.043, 0.007, 0.001 and 0.034 respectively).


CONCLUSIONS
PVP is an efficient pain-relieving procedure. The long/middle-term efficacy after PVP is mostly correlated with both the patient age and the natural course of underlying conditions.
Department of Radiology, Southeast University, Nanjing, China.
Wen-gui
WG
Liu
Shi-cheng
SC
He
Gang
G
Deng
Jin-he
JH
Guo
Wen
W
Fang
Guang-yu
GY
Zhu
Gao-jun
GJ
Teng
D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000601:surgery*; D006801:Humans; D008297:Male; D058866:Osteoporotic Fractures / Q000601:surgery*; D011446:Prospective Studies; D016103:Spinal Fractures / Q000601:surgery; D016896:Treatment Outcome; D054854:Vertebroplasty