The three dimensions of functional T-cell tolerance: from research to practice.
In this issue, Paek et al. describe two phenomena. First, they show that intermediate concentrations of a "transgenic" autoantigen may cause a lichen planus-like autoimmune disease. Second, and more importantly, they show that high doses of peptide antigen suppress the expression of the T-cell receptor and coreceptors, particularly CD8, and that this suppression improves this T-cell-mediated, destructive inflammatory skin disease that is similar to erosive lichen planus.
Department of Dermatology, Eberhard-Karls-University, Tübingen, Germany.
Christian
C
Hünefeld
Markus
M
Mezger
Michael
M
Röcken
Martin
M
Röcken
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D015551:Autoimmunity / Q000187:drug effects*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects*; D005260:Female; D008297:Male; D010047:Ovalbumin / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use; D011247:Pregnancy; D012871:Skin Diseases / Q000188:drug therapy*
C110366:OVA-8; D010446:Peptide Fragments; D010047:Ovalbumin