Association between vitamin D status and metabolic syndrome risk among Korean population: based on the Korean National Health and Nutrition Examination Survey IV-2, 2008.
OBJECTIVE
Low serum 25-hydroxyvitamin D (25(OH)D) levels have been linked to metabolic syndrome. However, community-based data for healthy Korean individuals are lacking. We aimed to assess the vitamin D status and the association of 25(OH)D deficiency with metabolic syndrome in the South Korean population (latitude 33-38°N).


METHODS
In this population-based study, we assessed 5559 South Korean adults selected from the Korean National Health and Nutrition Examination Survey IV-2, 2008. We used multiple logistic regression analysis to assess the association between vitamin D deficiency and metabolic syndrome.


RESULTS
The prevalence of vitamin D deficiency (<20 ng/mL) was 56.0%. Subjects with vitamin D deficiency were younger and had higher education, lower physical activity, and lower alcohol consumption than those with normal vitamin D levels. The overall risk of metabolic syndrome was not associated with 25(OH)D concentration. The adjusted OR of reduced high density lipoprotein cholesterol (HDL-C) decreased across the quintiles of 25(OH)D concentrations (OR=0.72; 95% confidence interval=0.54-0.95 for comparisons of lowest vs. highest quintile; P for trend=0.003).


CONCLUSIONS
A high prevalence of vitamin D deficiency was noted in the general South Korean population. Serum 25(OH)D concentration was inversely associated with the risk of having reduced HDL-C.
Department of Family Medicine, CHA University School of Medicine, Gyeongghi-do, South Korea.
Soyeun
S
Kim
Juwon
J
Lim
Soshin
S
Kye
Hyojee
H
Joung
D000328:Adult; D000368:Aged; D044466:Asian People; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D056910:Republic of Korea; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
D008076:Cholesterol, HDL; D014807:Vitamin D; C104450:25-hydroxyvitamin D