Analysis of beta1 and beta2-adrenergic receptors polymorphism in patients with apical ballooning cardiomyopathy.
OBJECTIVE
The aim of our study was to analyse the frequency of beta1 and/or beta2 adrenergic receptor polymorphisms in patients with takotsubo cardiomyopathy (TTC).


RESULTS
beta1 and/or beta2 adrenergic receptor polymorphisms in 61 patients with TTC were compared with 109 controls. The beta1 adrenoreceptor (amino acid position 389) genotype frequencies were significantly different in the two groups; assuming a recessive model for the allelic variant coding for Arg on this position, the odds ratio was 3.14, 95% Cl 1.55-6.37 (P = 0.0015). The beta2 adrenoreceptor amino acid position 27 genotype was significantly different and assuming a recessive model for the allelic variant coding for Gln on this position, the odds ratio was 0.29, 95% Cl 0.12-0.74 (P = 0.009).


CONCLUSIONS
This study showed for the first time an association between TTC phenotype and beta1 adrenoreceptor gene polymorphisms. Beta adrenoreceptors gene polymorphisms are probably disease modifiers, and any risk estimate should be based on a combination of genotypes and on interactions with other genes and environmental features.
Cardiologia, O.C. San Antonio, San Daniele del Friuli, Udine, Italy.
Olga
O
Vriz
Rosalba
R
Minisini
Rodolfo
R
Citro
Valentina
V
Guerra
Concetta
C
Zito
Giuseppe
G
De Luca
Daniela
D
Pavan
Mario
M
Pirisi
Giuseppe
G
Limongelli
Eduardo
E
Bossone
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D054549:Takotsubo Cardiomyopathy / Q000235:genetics*
D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2