Injectable magnesium-enriched hydroxyapatite putty in peri-implant defects: a histomorphometric analysis in pigs.
OBJECTIVE
The purpose of this study was to evaluate the healing of an injectable mixture of nanoparticles of magnesium-enriched hydroxyapatite (mHA) in peri-implant defects.


METHODS
Thirty-two dental implants were placed in 16 tibiae of eight female Large White pigs. In each animal, four implant beds (two sites each tibia) with medial three-wall intrabony defects were prepared. Via random selection, one bone defect in each tibia was filled with injectable mHA putty (n = 16, test group), whereas the other defect was not filled (n = 16, control group). Two animals were sacrificed after 2 weeks, two after 4 weeks, two after 6 weeks, and two after 8 weeks. In all, 32 block section samples were obtained for histologic and histomorphometric analyses.


RESULTS
The test group exhibited statistically significantly higher values for bone-to-implant contact (BIC) and lower amounts of connective tissue (CT) over time. The test group showed a remarkable increase in vital bone values between 6 and 8 weeks after implant placement. After 8 weeks, the injectable mHA was almost completely resorbed.


CONCLUSIONS
Injectable mHA putty could be a useful and suitable bone grafting material in peri-implant defects.
Department of Dentistry, Vita Salute University, San Raffaele Hospital, Milano, Italy. robcresp@libero.it
Roberto
R
Crespi
Paolo
P
Capparè
Alessandro
A
Addis
Enrico
E
Gherlone
D016301:Alveolar Bone Loss / Q000209:etiology / Q000628:therapy*; D000818:Animals; D018786:Bone Substitutes / Q000008:administration & dosage*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D017886:Durapatite / Q000008:administration & dosage*; D005260:Female; D007267:Injections; D008274:Magnesium / Q000008:administration & dosage*; D016348:Osseointegration / Q000187:drug effects*; D034421:Sus scrofa; D013977:Tibia / Q000601:surgery
D018786:Bone Substitutes; D017886:Durapatite; D008274:Magnesium