Generalized tonic-clonic seizure secondary to duloxetine poisoning: a short report with favorable out come.
Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) with a weak activity over dopamine reuptake used in the treatment of major depressive disorder. Daily doses of 60 mg are effective in treatment of major depression. There are few cases of isolated duloxetine overdose in humans. We think this is the first report of a generalized tonic-clonic seizure following isolated duloxetine poisoning with a very high dosage.
Child Neuropsychiatry Unit, University of Bologna, Italy.
Alessandro
A
Pellicciari
Beatrice
B
Balzarro
Annarosa
A
Scaramelli
Stefano
S
Porcelli
Alessandro
A
Serretti
Diana
D
De Ronchi
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D003865:Major Depressive Disorder / Q000188:drug therapy; D000068736:Duloxetine Hydrochloride; D004569:Electroencephalography; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D013876:Thiophenes / Q000009:adverse effects*
D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride