Assessment of antiplatelet activity of 2-aminopyrimidines.
A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.
Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara 390 001, India. rajanimsu@rediffmail.com
Rajani
R
Giridhar
Riyaj S
RS
Tamboli
R
R
Ramajayam
Dhaval G
DG
Prajapati
M R
MR
Yadav
D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C573639:4-(2'-hydroxy-4'-methoxyphenyl)-6-(2'',4''-dichlorophenyl)-2-aminopyrimidine; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; C012180:2-aminopyrimidine; D001241:Aspirin